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Sample records for som basal em

  1. Efeitos do som basal em fendas glóticas Effects of vocal fry incomplete glottal closure

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    Geovana de Paula Bolzan

    2008-01-01

    Full Text Available TEMA: som basal em fendas glóticas. PROCEDIMENTOS: participaram desta pesquisa dois sujeitos do sexo feminino, com idades entre 20 e 40 anos e diagnóstico otorrinolaringológico de fenda em ampulheta. Houve gravação da emissão sustentada da vogal /a/ e exame videolaringoestroboscópico, imediatamente a seguir, os sujeitos realizaram o som basal em três séries de 15 repetições, e foram submetidos a novo exame laríngeo e gravação da vogal. Os dados pré e pós-realização do som basal foram submetidos às analises acústica, perceptivo-auditiva e videolaringoestroboscópica, realizadas por juízes (três fonoaudiólogas e três otorrinolaringologistas, respectivamente. RESULTADOS: em ambos os sujeitos, houve melhora no fechamento glótico e amplitude de vibração da mucosa das pregas vocais; piora no tipo de voz; aumento das medidas de ruído e de Jitter. CONCLUSÃO: o som basal promoveu redução das fendas glóticas e aumento da amplitude de vibração da mucosa das pregas vocais; piora do tipo de voz, que ficou mais ruidoso; aumento das medidas de ruído e de Jitter, sugerindo irregularidade vibratória, provavelmente devido ao efeito do ajuste do som basal ao mobilizar intensamente a mucosa.BACKGROUND: vocal fry in incomplete glottal closure. PROCEDURE: two individuals aged between 20 and 40 years old presenting an otolaryngological diagnosis of ampoule chink were part of the study. A recording of the sustained emission of /a/ vowel took place, as well as a videostroboscopic examination. Right after, the individuals completed the vocal fry in three series of 15 repetitions, being submitted to a new laryngeal examination and to the vowel’s recording. Both pre-vocal and post vocal fry data were assessed through acoustic, perceptive-auditive and videostroboscopic analysis, carried out by judges (three speech and language pathologists and three otolaryngologists, respectively. RESULTS: for both individuals, there was an improvement

  2. Fissura palatina reparada: fechamento velofaríngeo antes e durante o som basal Cleft palate repair: velopharyngeal closure before and during the basal tone

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    Giseane Conterno

    2010-04-01

    Full Text Available Portadores de fissura palatina apresentam inadequado fechamento velofaríngeo (FVF, com consequente hipernasalidade vocal que pode ser diminuída com o som basal. OBJETIVO: Comparar o FVF durante a realização do som basal com a emissão em registro modal, em pacientes com fissura palatina pós-forame reparada. MATERIAIS E MÉTODOS: Estudo de Casos com quatro homens adultos, portadores de fissura palatina pós-forame reparada. Imagens do FVF por nasofaringoscopia, durante a emissão da vogal [a] em registro modal e basal. Julgamento das imagens realizado por quatro otorrinolaringologistas. RESULTADOS: Em três sujeitos, não houve mudança no tipo de FVF entre os registros analisados; as modificações que ocorreram na maioria dos sujeitos referem-se apenas ao grau de movimentação das estruturas envolvidas, pois, em registro basal, o movimento das paredes laterais da faringe se manteve, o movimento da parede posterior da faringe estabilizou, o movimento do véu palatino diminuiu discretamente, e a Prega de Passavant se evidenciou. CONCLUSÕES: O tipo de FVF se manteve em três dos quatro sujeitos analisados, quando comparado o registro modal com o basal, havendo modificações no grau da movimentação das estruturas envolvidas, evidenciando a Prega de Passavant.Patients with palatine fissure have inadequate velopharyngeal closure (VPC, with consequent vocal hypernasality which can be reduced by a basal tone. AIM: to compare VPC during a basal tone with the emission of a modal recording, in patients with repaired post-foramen palatine fissure. MATERIALS AND METHODS: case study with four adult men, all with repaired post-foramen palatine fissure. VPC images through nasal-pharyngoscopy during the emission o f the [a] vowel in a modal and basal recording. The images were studied by four ENTs. RESULTS: in three subjects there was no change in the type of VPC considering the recordings analyzed; the changes which happened to most of the subjects

  3. Músculo tiroaritenoideo e som basal: uma revisão de literatura Thyroarytenoid muscle and vocal fry: a literature review

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    Carla Aparecida Cielo

    2011-09-01

    Full Text Available O trabalho do fonoaudiólogo utiliza-se de exercícios vocais como o som basal (SB, que se origina da grande atividade contrátil do músculo laríngeo intrínseco tiroaritenoideo (TA. O objetivo deste estudo foi revisar a literatura relacionada ao TA e ao SB. Realizou-se levantamento bibliográfico dos últimos 20 anos sobre o assunto nas bases de dados LILACS, SciELO, PubMed, Web of Science e Google Scholar. Verificou-se que o feixe interno do TA apresenta fibras de contração lenta, isotônicas, resistentes à fadiga; o feixe externo apresenta fibras de contração rápida, fatigáveis, isométricas. O SB caracteriza-se pela percepção dos pulsos de vibração glótica durante a emissão nas frequências mais graves da tessitura vocal (crepitação em graves ou vocal fry, principalmente pela ação do TA, especialmente sua porção interna, que se encurta de forma evidente, soltando a mucosa em grande volume ao longo da borda livre, aumentando a pressão subglótica e os níveis de jitter, shimmer e ruído, e reduzindo o fluxo aéreo. Com base na literatura, a exercitação isométrica do TA externo ocorreria com o SB sustentado na frequência mais grave possível ao sujeito (contração máxima, durante seis segundos, de cinco a dez vezes diárias, compatível com o predomínio de fibras de contração rápida. Na exercitação isotônica do TA interno, utilizar-se-iam sons agudos para estirá-lo, alternando emissões em SB (contração concêntrica e em registro modal de cabeça ou em falsete (sons hiperagudos (contração excêntrica, com várias séries diárias de oito a 12 repetições, compatível com o predomínio de fibras de contração lenta.The work of speech-language pathologists uses exercises such as the vocal fry (VF, which originates from the great contractile activity of the intrinsic laryngeal thyroarytenoid muscle (TA. The aim of this study was to review the literature related to TA and VF. A literature review of the

  4. Indução e desenvolvimento de calos e embriões somáticos em mamoeiro

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    Almeida,Eliane Pires de; Oliveira,Roberto Pedroso de; Dantas,Jorge Luis Loyola

    2001-01-01

    Este trabalho teve por objetivo estabelecer um protocolo para a indução e desenvolvimento de calos e embriões somáticos em mamoeiro (Carica papaya L. cv. Tainung n.1). Foram utilizados quatro tipos de explantes (hipocótilo com folhas cotiledonares, hipocótilo, folhas cotiledonares e epicótilo) e duas condições de cultivo (escuro e 16 horas de luz). A indução e o desenvolvimento de calos foram avaliados nos meios de cultura ½MS2, ½MS10 e HMH e a indução e o desenvolvimento de embriões somático...

  5. Uso do ultra-som para punção venosa central em paciente obeso com adenomegalia cervical

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    Jaderson Wollmeister

    2008-08-01

    Full Text Available JUSTIFICATICA E OBJETIVOS: As técnicas clássicas para punção venosa central são realizadas com base em referências anatômicas de superfície e conhecimento da anatomia vascular da região em que se realizará a punção. O uso do ultra-som permite a realização da punção sob visão direta das estruturas vasculares, peri-vasculares e da agulha de punção. O objetivo deste relato foi descrever o uso do ultra-som no auxílio de acesso venoso central em paciente obeso e com adenomegalias. RELATO DO CASO: Paciente do sexo masculino, branco, 28 anos, 1,70 m, 120 kg, com diagnóstico de linfoma de Hodgkin esclerose nodular. Solicitado ao Serviço de Anestesiologia do Hospital Governador Celso Ramos, punção de veia jugular interna direita guiada por ultra-som devido à presença de gânglio supraclavicular que prejudicava a referência anatômica de punção e à obesidade do paciente. Após a obtenção da melhor imagem a veia jugular interna esquerda foi puncionada e colocado um cateter venoso de triplo lúmen. A punção foi única, com progressão fácil do cateter e realizada sem complicações. CONCLUSÕES: O uso da ultra-sonografia para punção venosa central pode evitar complicações tornando o procedimento mais seguro para o paciente.

  6. Indução de embriogênese somática em cana-de-açúcar RB935744

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    Rodrigo de Oliveira Almeida

    2014-06-01

    Full Text Available O objetivo deste trabalho foi avaliar a resposta morfogênica do genótipo RB935744 à indução de embriogênese somática com subsequente regeneração dos embriões. Segmentos transversais de folhas jovens medindo 2-3 mm de espessura foram cultivados em meio MS sólido contendo três diferentes concentrações de ácido 2,4-diclorofenoxiacético (2,4-D para indução de calos embriogênicos. Os melhores resultados foram obtidos usando 31.5 µM L-1 de 2,4-D em 45 ou 60 dias de incubação em meio de indução, realizando de um a três subcultivos e incubando em meio de regeneração por 15 a 45 dias. Este resultado mostra que o protocolo de embriogênese somática para o genótipo RB935744 necessita de ajustes para se alcançar uma satisfatória produção de embriões somáticos.

  7. Carcinoma basocelular em localizações incomuns Basal cell carcinoma in unusual locations

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    Ane Beatriz Mautari Niwa

    2006-10-01

    Full Text Available Os autores apresentam cinco pacientes que desenvolveram carcinomas basocelulares em locais incomuns de ocorrência desse tumor. O objetivo é relatar a raridade topográfica da neoplasia cutânea e discutir o conceito de localização incomum para o carcinoma basocelular.The authors present five patients who develop basal cell carcinomas in sites this tumor rarely occurs. The aim is to report the rare location of this frequent cutaneous malignancy and to briefly discuss the concept of unusual location of basal cell carcinoma.

  8. Indução e desenvolvimento de calos e embriões somáticos em mamoeiro Papaya callus and somatic embryo induction and development

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    Eliane Pires de Almeida; Roberto Pedroso de Oliveira; Jorge Luis Loyola Dantas

    2001-01-01

    Este trabalho teve por objetivo estabelecer um protocolo para a indução e desenvolvimento de calos e embriões somáticos em mamoeiro (Carica papaya L. cv. Tainung n.1). Foram utilizados quatro tipos de explantes (hipocótilo com folhas cotiledonares, hipocótilo, folhas cotiledonares e epicótilo) e duas condições de cultivo (escuro e 16 horas de luz). A indução e o desenvolvimento de calos foram avaliados nos meios de cultura ½MS2, ½MS10 e HMH e a indução e o desenvolvimento de embriões somático...

  9. Ultra-som terapêutico contínuo térmico em modelo experimental de ciatalgia Continuous thermic therapeutic ultrasound in sciatica experimental model

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    Adriano Polican Ciena

    2009-06-01

    Full Text Available O ultra-som é um recurso fisioterapêutico que pode atuar na redução dos sintomas da ciatalgia. O objetivo deste estudo foi verificar a eficácia do ultra-som terapêutico, no modo contínuo, em duas diferentes densidades de potência (0,5 W/cm² e 1 W/cm², na redução do quadro álgico em ratos submetidos a modelo experimental de ciatalgia. Foram utilizados 20 ratos, divididos em 3 grupos: G1 (n=6 submetido à ciatalgia e a tratamento placebo; G2 (n=7 submetido à ciatalgia e tratado com ultra-som com 0,5 W/cm²; e G3 (n=7 submetido à ciatalgia e tratado com ultra-som com 1 W/cm². A ciatalgia foi provocada por lesão cirúrgica de compressão do nervo no membro posterior direito de todos os animais. O tratamento na região do procedimento cirúrgico, iniciado no 3º dia pós-operatório, consistiu em 10 sessões diárias de 5 minutos. Verificou-se a dor pelo do tempo de elevação da pata (TEP durante a marcha, medido pré-cirurgia e em mais cinco momentos. Os resultados mostram aumentos no TEP em todos os grupos após a lesão; e, naqueles tratados com ultra-som terapêutico, houve diminuição significativa da TEP, restaurando-se os valores iniciais, sendo mais precoce e intensa em G2. Conclui-se que a entrega na forma continua do ultra-som terapêutico foi eficaz na redução da dor ciática.Therapeutic ultrasound is a physical therapy resource for relieving sciatic pain. The aim of this study was to assess the effectiveness of continuous therapeutic ultrasound in two different power densities (0,5 W/cm² and 1 W/cm², on reducing pain in rats submitted to a sciatica experimental model. Twenty rats were used, divided into 3 groups: G1 (n=6 submitted to sciatica and placebo treatment; G2 (n=7 submitted to sciatica and treated with 0.5 W/cm² ultrasound; and G3 (n=7, submitted to sciatica and treated with 1 W/cm² ultrasound. Sciatica was provoked by surgical nerve compression on the right posterior limb of all animals. Treatment on the

  10. Embriogênese somática em cana-de-açúcar e aspectos morfoanatômicos

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    Melo, Emanuelle Ferreira

    2011-01-01

    O presente estudo teve como objetivos avaliar os efeitos de diferentes tipos de explantes e reguladores de crescimento nas diferentes fases da embriogênese somática de cana-de-açúcar, cultivar RB867515 e caracterizar anatomicamente as fases deste processo nesta cultivar. Além disso, foi avaliada a regeneração in vitro, via embriogênese somática, nas cultivares RB855536 e RB92579. Na primeira etapa do trabalho foram avaliados o uso de dois tipos de explantes iniciais: folhas imaturas e ápices ...

  11. Somatic embryogenesis from zygotic embryos of Euterpe oleracea Mart. Embriogênese somática em embriões zigóticos de Euterpe oleracea Mart.

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    Ana da Silva Ledo

    2002-12-01

    Full Text Available The aim of this work was to study the morphogenetic responses of zygotic embryos of açai palm (Euterpe oleracea Mart. submitted to several conditions of in vitro culture. Several research experiments were conducted, in laboratory, using vegetable material collected from açai palm plants at Embrapa Amazon Oriental, Belém-PA, Brazil. It was possible to verify the expression of a direct, repetitive and no-synchronized model of somatic embryogenesis in mature zygotic embryos cultivated in primary MS medium supplemented with 2,4-D (339.36 muM and transferred to a secondary MS medium in the presence of NAA (0.537 muM and 2iP (12.30 muM. The conversion of somatic embryos into seedlings was reached after 210 days with the transfer of the cultures to a third medium with sucrose and mineral salts concentrations reduced to a half, without growth regulators.O objetivo do presente trabalho foi estudar as diferentes respostas morfogenéticas de embriões zigóticos de açaizeiro (Euterpe oleracea Mart. submetidos a várias condições de cultura in vitro. Os experimentos foram conduzidos em laboratório, com material vegetal coletado de plantas de açaí da Embrapa Amazônia Oriental, Belém-PA, Brasil. Foi possível verificar a expressão de um modelo de embriogênese somática direto, repetitivo e assincronizado em embriões zigóticos maduros cultivados em meio primário MS, suplementado com 339,36 miM de 2,4-diclorofenoxiacético (2,4-D, e transferidos para meio secundário MS na presença de 0,537 miM de ácido 1-naftalenoacético (ANA e 12,30 miM de 2-isopenteniladenina (2iP. A conversão de embriões somáticos em plântulas foi alcançada aos 210 dias da inoculação com a transferência das culturas para um terceiro meio com a concentração de sais e sacarose reduzida pela metade e ausência de reguladores de crescimento.

  12. Carcass traits of surubim (“Pseudoplatystoma” spp. evaluated by ultrasound Rendimento de carcaça em surubim ("Pseudoplatystoma" spp. avaliado por ultra-som

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    Daniela Chemim Melo

    2008-12-01

    é de lombo e do filé de barriga. Correlacionaram-se as medidas obtidas pelo ultra-som com aquelas de rendimento de carcaça. O ponto 3 apresentou as melhores correlações para rendimento dos peixes do grupo 1. Pelo ultra-som a área desse corte foi o parâmetro com maiores correlações com: carcaça (0,91, cabeça (0,86, filé de barriga (0,87 e filé de lombo (0,91. O rendimento de carcaça do grupo 1 (70,9% foi superior ao do grupo 2 (66,9%, possivelmente, em razão da maior porcentagem de cabeça destes animais. As equações com melhor predição para rendimento de carcaça e peso dos filés foram as que consideraram as medidas do ponto 3 e o comprimento total, respectivamente. A ultra-sonografia para avaliação de características de carcaça em surubins vivos é uma técnica confiável, o que possibilita a manutenção de peixes com características zootécnicas superiores dentro do plantel.

  13. Mobning som socialt begreb

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    Schott, Robin May

    2009-01-01

    Artiklen analyserer mobning i skolen som et socialt fænomen snarere end som en relation mellem individuelle mobbere og deres ofre. Denne tilgang afspejler nyere forskning, der har fokuseret på mobningens sociale dynamik, og står derved i modsætning til den individualistisk tilgang, der ellers har...... domineret feltet. Jeg undersøger tre definition af mobning: 1) mobning som en form for individuel aggression, 2) mobning som en slags samfundsmæssig vold og 3) mobning som en form for dysfunktionel gruppedynamik og kommer med et forslag til en ny definition....

  14. Influence of the power level of an ultra-sonic system on dental cavity preparation Influência do nível de potência de um sistema de ultra-som em preparos cavitários

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    Érika Botelho Josgrilberg

    2007-12-01

    Full Text Available The aim of this study was to evaluate the shape of dental cavities made with the CVDentus® system using different ultrasound power levels. One standard cavity was made on the buccal aspect of 15 bovine incisors with a CVDentus® cylindrical bur (82142. The sample was divided into three groups: G1 - ultrasound with power II; G2 - ultrasound with power III; and G3 - ultrasound with power IV. A standardizing device was used to obtain standardized preparations and ultrasound was applied during one minute in each dental preparation. The cavities were sectioned in the middle, allowing observation of the cavity’s profile with a magnifying glass, and width and depth measurement using the Leica Qwin program. The Kruskal-Wallis (p O objetivo deste estudo foi avaliar o formato dos preparos cavitários realizados com o sistema CVDentus® utilizando potências variadas do ultra-som. Uma cavidade padronizada foi realizada na face vestibular de 15 incisivos bovinos utilizando as pontas cilíndricas CVDentus® (82142. A amostra foi dividida em 3 grupos: G1 - ultra-som com potência II; G2 - ultra-som com potência III; e G3 - ultra-som com potência IV. Foi utilizada uma máquina padronizadora de preparos cavitários e o ultra-som foi aplicado durante 1 minuto em cada preparo. As cavidades foram seccionadas no centro, permitindo a visualização do perfil cavitário em uma lupa estereoscópica, e esse foi medido em largura e profundidade por meio do programa Leica Qwin. O teste estatístico Kruskal-Wallis (p < 0,05 e o método de Dunn demonstraram diferenças entre os formatos das cavidades produzidas com as potências III e IV. Entretanto, as cavidades realizadas com a potência III apresentaram dimensões semelhantes às da ponta utilizada. Concluiu-se que a potência indicada pelo fabricante (III é a mais adequada para uso do sistema CVDentus®.

  15. Níveis séricos de cortisol basal em ratos sob tratamento oral com kefir

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    Bárbara de Oliveira Prado

    2013-08-01

    Full Text Available A via de metabolismo do kefir ainda é desconhecida em muitas funções, pois há poucos estudos que a evidenciam. Assim a proposta do presente estudo é avaliar o efeito do kefir sobre os níveis séricos de cortisol basal. Um Estudo experimental em que foram utilizados 60 ratos, machos, wistar, peso de 180±30g, sendo 20 animais de experimento por 07, 14 e 21dias, divididos em Kefir 20g/200ml (GK; Dexametasona 0,125mg/kg (GD; Ranitidina 0,85mg/kg (GR; Omeprazol 0,68mg/kg (GO; Controle água ad libitum (GCO. Os resultados foram avaliados pelo Software BioEstat 5.0, e para verificação do nível de significância (α<5% usou-se a ANOVA com o teste Tukey-kramer e Bartlett’s test. Os resultados obtidos revelaram que o cortisol basal (µg/dL do sangue de 60 ratos (Rattus norvegicus submetidos ao tratamento, com D7 (P<0.05, evidenciou no GR uma média representativa sobre os demais grupos com 2.2075 μg/dl, e desvio padrão (SD de 0.4329 μg/dl. Já em D14, as alterações evidenciadas foram relativamente mínimas e pouco representativas, com D21 quando relacionado o GO e GR (P<0.01, ao que tange a relação entre o GK e o GD apresentou diferenças significativas (P< 0,001. A média no GK foi de 3,4 μg/dl com um SD de 0,3238 μg/dl sobre os demais grupos experimentais, o GD apresentou níveis muito baixos de cortisol com 0,0275μg/dl e o SD de 0,009574 μg/dl. Conclui-se que o Kefir, quando consumido em doses contínuas e diariamente, repercutiu na elevação dos níveis séricos de cortisol. Não foi possível estabelecer a via de mecanismo que tenha contribuído para tal, entretanto, esse aumento ocorreu sem que os animais sofressem qualquer tipo de dano, ou seja, os animais submetidos ao tratamento com kefir mostraram-se mais vistosos, pelagem firme e com brilho, esboçando aspecto saudável.

  16. Intelligent design som videnskab?

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    Klausen, Søren Harnow

    2007-01-01

    Diskuterer hvorvidt intelligent design kan betegnes som videnskab; argumenterer for at dette grundet fraværet af klare demarkationskriterier næppe kan afvises.......Diskuterer hvorvidt intelligent design kan betegnes som videnskab; argumenterer for at dette grundet fraværet af klare demarkationskriterier næppe kan afvises....

  17. Gipskroppe som performance

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    Holm, Henrik

    2010-01-01

    Analyse af den Kgl. Afstøbningssamlings nøgne gipsfigurer og samlingens nedtur igennem historien, med Judith Butler og andres performativitetsteorietiske begrebsapparat som metode.......Analyse af den Kgl. Afstøbningssamlings nøgne gipsfigurer og samlingens nedtur igennem historien, med Judith Butler og andres performativitetsteorietiske begrebsapparat som metode....

  18. Yoga som terapeutisk aktivitet

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    Broge, Julie Wolf

    2014-01-01

    Artiklen præsenterer yoga som terapeutisk aktivitet til børn og unge med særlige behov. Den gavnlige virkning af yoga uddybes.......Artiklen præsenterer yoga som terapeutisk aktivitet til børn og unge med særlige behov. Den gavnlige virkning af yoga uddybes....

  19. Leg som ustyrlig deltagelseskultur

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    Toft, Herdis

    2017-01-01

    - og spilteoretikere Johan Huizinga og Roger Caillois. Deres teorier og begrebsdannelser har været brugt til at påpege leg dels som et æstetisk baseret betydningssystem, dels som et affektivt og stemningsbaseret oplevelsessystem samt endelig som et socialt baseret relationssystem. I artiklen vælger vi...... at fokusere på leg som et socialt baseret relationssystem og yderligere zoome ind på et af legens systemiske væsenstræk, nemlig brugen af regulerbare regelsæt, som legerne uden ’politi’ forhandler sig frem til før, under og efter legen. Fælles for Huizinga og Caillois er, at de knytter leg uløseligt sammen...

  20. Validação de equações de predição da taxa metabólica basal em mulheres residentes em Porto Alegre, RS, Brasil

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    Wahrlich Vivian

    2001-01-01

    Full Text Available OBJETIVO: Medir a taxa metabólica basal em mulheres de 20 a 40 anos, não-gestantes ou lactantes, e comparar o valor medido com os valores de taxa metabólica basal estimados por equações de predição. MÉTODOS: A taxa metabólica basal foi medida por calorimetria indireta, pela manhã, durante a fase folicular do ciclo menstrual, em 60 voluntárias residentes no município de Porto Alegre, RS, sob condições padronizadas de jejum, repouso e ambiente. RESULTADOS: A média (± desvio-padrão da taxa metabólica basal medida foi 1.185,3±148,6 kcal em 24 horas. A taxa metabólica basal, estimada por equações, foi significativamente maior (7% a 17% do que a taxa metabólica basal medida. CONCLUSÕES: Os dados evidenciaram que as equações de predição não são adequadas para estimar a taxa metabólica basal nas mulheres avaliadas. O emprego dessas equações podem superestimar os requerimentos energéticos para mulheres com características semelhantes.

  1. Validação de equações de predição da taxa metabólica basal em mulheres residentes em Porto Alegre, RS, Brasil

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    Vivian Wahrlich

    2001-02-01

    Full Text Available OBJETIVO: Medir a taxa metabólica basal em mulheres de 20 a 40 anos, não-gestantes ou lactantes, e comparar o valor medido com os valores de taxa metabólica basal estimados por equações de predição. MÉTODOS: A taxa metabólica basal foi medida por calorimetria indireta, pela manhã, durante a fase folicular do ciclo menstrual, em 60 voluntárias residentes no município de Porto Alegre, RS, sob condições padronizadas de jejum, repouso e ambiente. RESULTADOS: A média (± desvio-padrão da taxa metabólica basal medida foi 1.185,3±148,6 kcal em 24 horas. A taxa metabólica basal, estimada por equações, foi significativamente maior (7% a 17% do que a taxa metabólica basal medida. CONCLUSÕES: Os dados evidenciaram que as equações de predição não são adequadas para estimar a taxa metabólica basal nas mulheres avaliadas. O emprego dessas equações podem superestimar os requerimentos energéticos para mulheres com características semelhantes.

  2. Supervision som undervisningsform i voksenspecialundervisningen

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    Kristensen, René

    2000-01-01

    Supervision som undervisningsform i voksenspecialundervisningen. Procesarbejde i undervisning af voksne.......Supervision som undervisningsform i voksenspecialundervisningen. Procesarbejde i undervisning af voksne....

  3. Komponist som kirkefader?

    DEFF Research Database (Denmark)

    Petersen, Nils Holger

    2016-01-01

    En diskussion primært af Karl Barths anvendelse Mozart in sin Kirchliche Dogmatik under læren om "das Nichtige", som en slags løsning på theodicé-problemet.......En diskussion primært af Karl Barths anvendelse Mozart in sin Kirchliche Dogmatik under læren om "das Nichtige", som en slags løsning på theodicé-problemet....

  4. Straf som penibel ledelsesform

    DEFF Research Database (Denmark)

    Knudsen, Hanne; Bjerg, Helle

    2014-01-01

    Kan klasseledelse fungere uden muligheden for at straffe? Kan man have en skole uden straf? Hvis man ser tilbage på skolens historie, ser svaret ud til at være nej. Skolen som institution ser ud til at være uløseligt forbundet med disciplinering af eleverne til at gøre noget, som de ikke nødvendi...

  5. Musik som analogi og metafor

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    2014-01-01

    Indeholder underkapitlerne: 2.5.1 Musik som analogi 2.5.2 Musik som metafor 2.5.3 Musikkens psykologiske funktioner - en taxonomi og metaforisk lytning til fire baroksatser......Indeholder underkapitlerne: 2.5.1 Musik som analogi 2.5.2 Musik som metafor 2.5.3 Musikkens psykologiske funktioner - en taxonomi og metaforisk lytning til fire baroksatser...

  6. Validação de equações de predição da taxa metabólica basal em mulheres residentes em Porto Alegre, RS, Brasil Validation of predictive equations of basal metabolic rate of women living in Southern Brazil

    Directory of Open Access Journals (Sweden)

    Vivian Wahrlich

    2001-02-01

    Full Text Available OBJETIVO: Medir a taxa metabólica basal em mulheres de 20 a 40 anos, não-gestantes ou lactantes, e comparar o valor medido com os valores de taxa metabólica basal estimados por equações de predição. MÉTODOS: A taxa metabólica basal foi medida por calorimetria indireta, pela manhã, durante a fase folicular do ciclo menstrual, em 60 voluntárias residentes no município de Porto Alegre, RS, sob condições padronizadas de jejum, repouso e ambiente. RESULTADOS: A média (± desvio-padrão da taxa metabólica basal medida foi 1.185,3±148,6 kcal em 24 horas. A taxa metabólica basal, estimada por equações, foi significativamente maior (7% a 17% do que a taxa metabólica basal medida. CONCLUSÕES: Os dados evidenciaram que as equações de predição não são adequadas para estimar a taxa metabólica basal nas mulheres avaliadas. O emprego dessas equações podem superestimar os requerimentos energéticos para mulheres com características semelhantes.OBJECTIVE: To measure the basal metabolic rate of women (aged 20 to 40 years living in Porto Alegre, Brazil, and to compare it with estimated values bored on published predictive equations. METHODS: Basal metabolic rate was measured by indirect calorimetry under standard conditions in the follicular phase of the menstrual cycle of 60 volunteers. RESULTS: Mean measured basal metabolic rate (± standard deviation was 1,185.3± 148.6 kcal/24 hours. Estimated basal metabolic rates were significantly greater (7% to 17% than measured basal metabolic rate (p<0.0001. CONCLUSIONS: These results show that predictive equations are not suitable to estimate basal metabolic rate in these groups of women and that the use of estimated basal metabolic rate will lead to an overestimation of energy requirements in women with similar characteristics.

  7. Ultra-som pulsado de baixa intensidade em fraturas diafisárias: aplicação clínica em cães Low-intensity pulsed ultrasound in diaphyseal fractures: clinical application in dogs

    Directory of Open Access Journals (Sweden)

    Valéria Lima de Sousa

    2008-08-01

    Full Text Available Os efeitos da estimulação ultra-sônica sobre a consolidação óssea têm sido demonstrados por trabalhos experimentais e clínicos. Este estudo teve por objetivo investigar a aplicação clínica do ultra-som pulsado de baixa intensidade como tratamento adjuvante de fraturas diafisárias em cães. Foram utilizados 16 cães de raças variadas, com faixa etária entre sete meses e seis anos, peso corpóreo entre 2,5 e 43kg, portadores de fraturas diafisárias fechadas recentes localizadas no rádio e ulna, fêmur ou tíbia e fíbula, estabilizadas por procedimentos de osteossíntese (fixação esquelética externa, pinos intramedulares ou a associação desses métodos. Os cães foram divididos em dois grupos: fraturas estabilizadas tratadas por ultra-som de baixa intensidade (grupo tratado, n=8; fraturas estabilizadas, não tratadas por estimulação ultra-sônica, (grupo controle, n=8. Os animais foram avaliados por exames clínicos e radiográficos nos períodos pré-operatório, pós-operatório imediato e a cada 30 dias posteriores aos procedimentos cirúrgicos. Realizou-se tratamento com ultra-som pulsado (sinal senoidal com freqüência de 1,5MHz, largura de pulso de 200µs e freqüência de repetição de 1kHz de baixa intensidade (30mW cm-2, aplicado de modo estacionário no foco de fratura. A terapia ultra-sônica foi realizada 20 minutos por dia, durante 21 dias consecutivos, a partir do período compreendido entre o 1° e o 9° dia pós-operatório. O teste t de Student, empregado na análise estatística, mostrou diferença significante (PThe effects of ultrasound stimulation on bone healing have been demonstrated in experimental and clinical studies. The purpose of this study was to investigate the clinical application of low-intensity pulsed ultrasound as an adjuvant for the treatment of diaphyseal fractures in dogs. Sixteen dogs of different breeds, ages ranging from seven months to six years, weighing from 2.5 to 43kg, were

  8. Avaliação da apoptose de leucócitos polimorfonucleares CH138+ em leite bovino de alta e baixa contagem de células somáticas : dados preliminares

    Directory of Open Access Journals (Sweden)

    R.B Pessoa

    2012-06-01

    Full Text Available A apoptose de leucócitos polimorfonucleares (PMN é um evento central no processo de resolução da inflamação. Sendo a contagem de células somáticas (CCS um indicador da situação imunológica da glândula mamária, o presente estudo buscou esclarecer a influência que esses fatores têm um sobre o outro e sobre a evolução do processo inflamatório. Marcaram-se as amostras de leite com anexina-V, iodeto de propídeo (PI, anticorpo anti-CH138A. Encontrou-se correlação negativa entre apoptose de PMN e CCS, além de diferença estatística entre um grupo de alta CCS e um grupo de baixa CCS quanto à taxa de PMN viáveis, em apoptose, em necrose e em necrose e/ou apoptose. De modo geral, o grupo de alta celularidade apresentou menos CH138+ em apoptose e mais células em necrose ou viáveis do que o grupo de baixa celularidade. Conclui-se que apoptose de PMN e CCS estão relacionados, e que em mamas com CCS elevada este evento está diminuído. Apesar de haver maior disponibilidade de fagócitos para a defesa nessa situação, os efeitos anti-inflamatórios da apoptose também estão diminuídos, enquanto os efeitos pró-inflamatórios da necrose estão aumentados, o que pode colaborar com a cronificação da inflamação.

  9. Boken som medium

    OpenAIRE

    Pelle, Snickars

    2012-01-01

    I slutet av september 2011 presenterade Amazon ett ny slags surfplatta, Kindle Fire. Till skillnad från företagets tidigare läsplattor, som (nästan) enbart handlat om läsning på skärm, var detta en Kindle som behärskade hela det samtidsmediala spektrat. Under ledning av Amazons VD Jeff Bezos var själva lanseringen av Kindle Fire visserligen en ganska platt historia. Bezos är ingen estradör och en föga karismatisk företagsledare med än mindre publikreaktioner gör inte någon succé – eller som e...

  10. Histologia da embriogênese somática induzida em embriões de sementes maduras de Urochloa brizantha apomítica Histology of somatic embryogenesis induced in embryos of mature seeds of the apomictic Urochloa brizantha

    Directory of Open Access Journals (Sweden)

    Sandra Janeth Lenis-Manzano

    2010-05-01

    Full Text Available O objetivo deste trabalho foi descrever o processo de embriogênese somática em Urochloa brizantha cv. Marandu (Syn. Brachiaria brizantha cv. Marandu e fornecer subsídios para o aprimoramento dos métodos de cultura de tecidos e transformação genética. Calos embriogênicos foram obtidos por indução em embriões isolados de sementes maduras, e cultivados in vitro, em meio de cultura que continha ácido 2,4-diclorofenoxiacético, 6-benzilaminopurina e caseína hidrolisada. Plântulas foram regeneradas a partir dos calos embriogênicos, na presença de ácido naftalenoacético e cinetina. Esse processo foi descrito morfologicamente por observações em microscopia de luz de secções seriadas semifinas de tecidos fixados, ao longo do processo de regeneração, em FAA [formaldeído (40%: ácido acético glacial: etanol (50%, a 5:5:90 v/v/v]. Os embriões das sementes de U. brizantha cv. Marandu não têm epiblasto e são classificados como do tipo panicoide. Nas condições estabelecidas de cultura in vitro, calos embriogênicos e embriões somáticos de U. brizantha cv. Marandu, desenvolvem-se a partir de células meristemáticas do escutelo.The objective of this work was to describe the process of somatic embryogenesis in Urochloa brizantha cv. Marandu (Syn. Brachiaria brizantha cv. Marandu and to provide support for the improvement of tissue culture and genetic transformation methods. Embryogenic calli were obtained by induction in embryos isolated from mature seeds, and cultivated in vitro in culture medium containing 2,4-dichlorophenoxyacetic acid, 6-benzylaminopurine and hydrolyzed casein. Plantlets were regenerated from the embryogenic calli in the presence of naphthaleneacetic acid and kinetin. This process was described by morphological observations of serial semithin sections of tissues fixed along the regeneration process in FAA (40% formaldehyde: acetic acid: 50% ethanol, at 5:5:90 v/v/v, using light microscopy. Seed embryos of U

  11. Gruppeeksamen som strategisk kommunikation

    DEFF Research Database (Denmark)

    Andersen, Tem Frank; Bang, Janne

    2014-01-01

    Artiklen har fokus på at skabe et grundlag for en teoretisk diskussion af gruppeeksamen som den bedste og mest egnede form for eksamen, når problembaseret læring er mål og middel i regi af Aalborg Universitet.......Artiklen har fokus på at skabe et grundlag for en teoretisk diskussion af gruppeeksamen som den bedste og mest egnede form for eksamen, når problembaseret læring er mål og middel i regi af Aalborg Universitet....

  12. Diagnoser som styringshybrider

    DEFF Research Database (Denmark)

    Bossen, Claus; Danholt, Peter; Ubbesen, Morten Bonde

    2016-01-01

    - Relaterede Grupper (DRG). DRG er et internationalt udbredt system til at knytte patienter og deres behandlingsomkostninger sammen i faste kategorier med henblik på at måle hospitalers produktivitet. Med afsæt i Science-Technology-Studies (STS)-feltet analyserer artiklen, hvorledes diagnoser overskrider deres......, hvordan DRG-systemet alternativt kan anskues som en samfundsudviklende infrastruktur, idet det forsamler og skaber gensidigt involverende interaktioner imellem politiske, administrative og sundhedsprofessionelle domæner. En sådan indsigt bidrager til en udvidet forståelse af infrastrukturers roller som...

  13. Lannister som statsminister

    DEFF Research Database (Denmark)

    Konzack, Lars

    2014-01-01

    Der er fuld skrue på intriger, sex og død i Game of Thrones. Det er stærkt underholdende og kan også ses som et billede på de moderne politiske spil. Hvem er seriens Putin? Og hvilken politisk leder ligner Prins Joffrey?......Der er fuld skrue på intriger, sex og død i Game of Thrones. Det er stærkt underholdende og kan også ses som et billede på de moderne politiske spil. Hvem er seriens Putin? Og hvilken politisk leder ligner Prins Joffrey?...

  14. Kollektivet som korrektiv

    DEFF Research Database (Denmark)

    Krøjer, Jo; Hutters, Camilla

    2008-01-01

    I Danmark har de unge individuel valgfrihed, når det kommer til valget af videregående uddannelse. Der er ikke nogen uddannelsespligt - valget er op til den unge. Den etablerede uddannelsesvejledning initierer et selvarbejde, hvorunder de unge anspores til at arbejde individuelt med at træffe det...... rette uddannelsesvalg. De unge oplever uddannelsesvalget som et ensomt og belastende arbejde. Så hvad sker der, når unge kollektivt reflekterer over at skulle vælge uddannelse? Artiklen præsenterer fortælleværksteder som metode til kollektive korrektioner af neoliberal regulering....

  15. Caracterização da preferência sistemática por um som em casos de desvio fonológico

    Directory of Open Access Journals (Sweden)

    Keske-Soares, Marcia

    2008-01-01

    Full Text Available O objetivo deste trabalho foi analisar o sistema fonológico de cinco crianças com preferência sistemática por um som de acordo com os estudos de Weiner (1981 e Yavas e Hernandorena (1989, 1991. A amostra está composta por cinco sujeitos (quatro meninos e uma menina, com idade de 6: 4 (S1, 4: 11 (S2, 4: 4 (S3, 5: 5 (S4 e 5: 1 (S5. Os dados de fala foram snalisados através da avaliação fonológica. Para análise da fala utilizaram-se análises contrastiva e de traços. Os sesultados obtidos na análise dos dados de fala dos cinco sujeitos são descritos e comparados aos padrões identificados pelos autores acima citados quanto à preferência sistemática por um som. O S1 apresenta preferência por /s/e/z/, afetando a classe das fricativas; S2, por /f/ e /v/, substituindo fricativas e plosivas; S3, por /t/ e /d/, afetando as fricativas; S4 por /k/ e /g/ afetando plosivas e fricativas; S5, pela global /?/, substituindo fricativas e plosivas. Conclui-se que os resultados confirmam que o nível do desvio é variável, com o sistema fonológico ininteligível devido á perda de contraste. Porém, é necessário estudar um número maior de sujeitos e saber o tipo de desordem para atentar para o diagnóstico e a terapia. Além disso, é importante que os terapeutas da fala, ao detectarem e tratarem o desvio fonológico, conheçam as características dos sistemas com preferência sistemática por um som

  16. Insulin som trickster

    DEFF Research Database (Denmark)

    Lassen, Aske Juul

    2011-01-01

    grænser nedbrydes i en konstant penetrering af huden, når blodsukkeret måles eller insulinen indsprøjtes. Insulin analyseres som en tricksterfigur, der udøver et grænsearbejde på kroppen, leger med dens kategorier og vender forholdet mellem gift og medicin, frihed og ufrihed, kunstighed og naturlighed...

  17. Digitalisering som kulturpolitik

    DEFF Research Database (Denmark)

    Lund, Niels Dichov

    2009-01-01

    Begreberne kulturarv, digitalisering og formidling drøftes generelt som væsentlige nutidsagendaer i lyset af en treeninghed af teknologi, demokrati og kultur. Digital formidling af kulturarv belyses i forhold til en længere dobbbeltsporet forskningskontekst mellem IKT og humaniora og ses primært...

  18. Industrirobotten som servomekanisme

    DEFF Research Database (Denmark)

    Sørensen, Torben

    2001-01-01

    ). Bevægeleddene er typisk enten roterende drejeled, eller lineære forskydningsled. Rotationen eller forskydningen mellem to bevægeled varetages af en servostyret motor. Selve robotarmen er forbundet til robottens base gennem et bevægeled (servoakse) som bærer hele armen - det vil sige alle armens elementer og...

  19. Krisen som udfordring

    DEFF Research Database (Denmark)

    Højrup, Thomas

    2009-01-01

    Om Thorupstrand Kystfiskerlaug, Han Herred Puljefiskeri og Han Herred Havbådes innovative bidrag til en samlet indsats for at sikre kystfiskeriet i Skagerrak fra åben strand som en levende og håndværksbåret kystkultur i Danmark. Den venturekapitalistiske højkonjunktur, regeringens privatiseringsp...

  20. Turistkort som geografisk kommunikation

    DEFF Research Database (Denmark)

    Nielsen, Niels Christian

    2009-01-01

      Kort har længe spillet en central rolle i turisters ferieplanlægning og aktiviteter på feriestedet, og forventes at gøre det i fremtiden, suppleret med andre kilder til geografisk information. Men først i forbindelse med introduktionen af GIS og mobile applikationer som telefon og GPS er den...

  1. Sprog som musikalsk notation

    DEFF Research Database (Denmark)

    Bergstrøm-Nielsen, Carl

    Artiklen behandler sprogbrug som supplement til noderne fra barokken og frem; Fluxus og Scratch Orchestra; den engelske Verbal Anthology; Stockhausens brug af verbal notation før tekst-samlingerne; detaljerede analyser af de to samlinger. Der konkluderes bla. om forskellige grader af fastlæggelse...

  2. Selvskade som selvteknologi

    DEFF Research Database (Denmark)

    Rasmussen, Anna Lanken; Rasmussen, Svend Aage

    2016-01-01

    livshandlinger” – selvskade som social lidelse. Herefter argumenterer forfatterne med udgangspunkt i et feltstudie af Helen Gremillion for vigtigheden af at kaste et kritisk blik på behandlingskultur. Denne kritik videreføres i et afsnit om den postmoderne udfordring i forhold til selvskade. Afslutningsvis...

  3. Som at noget lettede

    DEFF Research Database (Denmark)

    Berliner, Peter; Glendøs, Mia

    2010-01-01

    Den høje voldsrate i Kalaallit Nunaat (Grønland) forklares ofte ud fra alkoholmisbrug og affektive handlinger. I denne artikel vises det gennem en kvantitativ og kvalitativ undersøgelse, at den episodiske vold må forstås som symptomer på strukturel vold. Den strukturelle vold er en kontekst, der ...

  4. Studerende som co-creators

    DEFF Research Database (Denmark)

    Andersen, Line Palle

    En kogebog blev udviklet med studerende som co-creators på 3 moduler om innovation, skriftlig kommunikation og praktik med redigering. Healeys model om student-partnerships blev anvendt som fundament......En kogebog blev udviklet med studerende som co-creators på 3 moduler om innovation, skriftlig kommunikation og praktik med redigering. Healeys model om student-partnerships blev anvendt som fundament...

  5. Kakkelovnen som arkiv

    DEFF Research Database (Denmark)

    Duedahl, Poul

    2005-01-01

    "Folk gjorde såmænd klogt i at gøre som jeg - jeg bruger kakkelovnen som arkiv" gentog tidligere konseilspræsident J.C. Christensen (1856-1930) ofte over for venner og bekendte. Selv destruerede han de fleste af sine breve, mens han var i live, og i mange år troede man, at hans dagbøger blev bræn...... anledning til nogle refleksioner over, hvad man skal stille op med dem; hvad det er, der får folk til at skrive dagbøger og hvad det er, der får folk til at skille sig af med dem igen....

  6. Informatikken som utopi

    Directory of Open Access Journals (Sweden)

    Jørgen Poulsen

    1986-08-01

    Full Text Available Medieforskerne mødte den nye informationsteknologi med be- tydelig skepsis i begyndelsen af 1980érne. Nu synes pendu- let at være i et andet yderpunkt og utopierne omkring in- formatikkens muligheder blomstrer. Denne artikel forsøger at se informationsteknologien i et socialt perspektiv, i forhold til brugen af andre medier, især TV og radio, og ikke som en kraft "i sig selv". Vores behov for at udføre nye kommunikative handlinger vil være afgørende for infor- matikkens succes. Og her véd vi faktisk moget: I analysen af behovene og deres sociale kontekst (som visse informa- tikutopister synes at glemme synes indsigterne fra de sid- ste 20 års positivestiske og kritiske medieforskning at være brugbare.

  7. Fantasy som religion

    DEFF Research Database (Denmark)

    Davidsen, Markus

    2010-01-01

    Artiklen redegør for George Lucas' religionspædagogiske projekt med Star Wars og jediismens brug af Star Wars som religiøs tekst i en fantasybaseret religion. Afslutningsvist gives en række forslag til hvordan man kan anvende Star Wars og jediismen i folkeskolens religionsundervisning.......Artiklen redegør for George Lucas' religionspædagogiske projekt med Star Wars og jediismens brug af Star Wars som religiøs tekst i en fantasybaseret religion. Afslutningsvist gives en række forslag til hvordan man kan anvende Star Wars og jediismen i folkeskolens religionsundervisning....

  8. Determinação da taxa metabólica basal em cutias, Dasyprocta azarae, por calorimetria indireta Determination of the basal metabolic rate in agoutis, Dasyprocta azarae, by indirect calorimetry

    Directory of Open Access Journals (Sweden)

    Harald F.V. Brito

    2010-06-01

    Full Text Available A melhor ferramenta para comparação fisiológica entre organismos diferentes é a taxa metabólica basal, inter-relação fundamental que existe entre todos os seres vivos. Mensurações diretas das concentrações de oxigênio e dióxido de carbono, pela análise do ar inspirado e expirado, podem ser usadas para a mensuração de taxa metabólica. Este trabalho foi executado com o propósito de aferir as taxas metabólicas basal e específica, e reexaminar o escalonamento do metabolismo basal em cutias (Dasyprocta azarae. Foram utilizadas 34 cutias (D. azarae adultas sadias, sendo 9 machos não castrados, 9 machos castrados e 16 fêmeas, pertencentes ao plantel do Criadouro Científico do Museu de História Natural Capão da Imbuia, Curitiba, PR. Os animais passaram por jejum prévio de 6 horas e foram acondicionados em caixas especiais, com temperatura ambiente controlada (22,0±1,0ºC, sendo então submetidos à aferição da taxa metabólica basal, por calorimetria indireta. Empregou-se o monitor metabólico Deltatrac®II, (Datex Ohmeda, Finlândia usualmente indicado para a mensuração da produção de dióxido de carbono (VCO2 e do consumo de oxigênio (VO2 em seres humanos, por meio da mensuração das variações na concentração de VCO2 e de VO2, com uma precisão de 0,01%. Após a aferição da taxa metabólica basal, foi calculada a taxa metabólica específica, e efetuada a análise dos dados por estatística indutiva. Os testes de hipóteses para comparação entre amostras indicaram que a taxa metabólica específica de machos não castrados é maior que a de fêmeas e machos castrados (5% de significância, e que a taxa metabólica específica de fêmeas e machos castrados é equivalente (1% de significância. Constatou-se ainda, com a análise da correlação de pontos experimentais, que outra variável que não o tamanho corporal afeta a taxa metabólica dos machos não castrados (1% de significância, o que indica a

  9. Artikelskrivning som eksamensform

    Directory of Open Access Journals (Sweden)

    Lars Domino Østergaard

    2013-09-01

    Full Text Available I denne artikel vil vi diskutere, hvordan studerendes arbejde med udformning af en videnskabelig artikel som afsæt for summativ evaluering af undervisningsmoduler, kan bidrage såvel til de studerendes oplevelse af motivation som til oplevelse af, at de gives muligheder for at udvikle konkrete aka­demiske kompetencer. Vi tager udgangspunkt i en række teoretiske over­vejelser, der knytter den summative evaluering til begreber som autentiske rammer, kompetenceudvikling og motivation. Disse overvejelser supplerer vi med resultaterne af en konkret undersøgelse af et pilotforsøg gen­nem­ført ved 2. semester på kandidatuddannelsen i Idræt på Aalborg Uni­versitet. I relation til to kursusmoduler har de studerende udarbejdet en videnskabelig artikel med afsæt i indsamlet empiri. Undersøgelsen viser, at de studerende i altovervejende grad er positive over for artikelskrivning som udgangspunkt for deres evaluering. Undersøgelsen viser videre, at de studerende oplever en følelse af motivation ved bl.a. at arbejde med selv­valgte problemstillinger. Hvorvidt de studerende faktisk udviklede kom­­petencer i forløbet, som de ikke kunne udvikle ved andre evalueringsformer, er fortsat ikke afdækket men vil være et naturligt næste genstandsfelt for undersøgelse.     In this paper we discuss how setting students a scientific paper to write as part of their course module summative assessment may help motivate students and contribute to their academic competencies. We depart from theoretical considerations that connect summative evaluation to concepts of authentic frameworks, competence development and motivation, and instead argue that writing a scientific paper as part of evaluation may be both motivational to students and provide a framework for developing competencies. We supplement these observations by presenting the results from a study conducted in a 2nd semester master programme in sport science at Aalborg University, Denmark

  10. Efeitos do ultra-som terapêutico sobre o crescimento longitudinal do fêmur e da tíbia em ratos Effects of therapeutic ultrasound on longitudinal growth of the femur and tibia in rats

    Directory of Open Access Journals (Sweden)

    Alfredo Alcantara Barreto

    2011-01-01

    Full Text Available OBJETIVO: Estudar efeitos do ultra-som terapêutico sobre o crescimento do fêmur e da tíbia, em ratos jovens. MÉTODO: Ratus norvegicus com quatro semanas de vida, machos, totalizando 115 animais, divididos em quatro grupos, foram submetidos ao ultra-som terapêutico (0,8 MHz, cabeçote fixo, pulso contínuo, por dez minutos, durante dez dias, na face medial do joelho direito, nas potências de 0,0 W/cm2 (grupo controle, 0,5 W/cm2 (grupo G2, 1,0 W/cm2 (grupo G3, e 1,5 W/cm2 (grupo G4. Lâminas histológicas da epífise, placa de crescimento e metáfise e as medidas dos comprimentos do fêmur e da tíbia foram estudadas na sexta, décima terceira e vigésima sexta semanas de vida. Os dados foram submetidos à análise de variância - fatorial inteiramente aleatorizado. RESULTADO: Nenhuma alteração estatística do crescimento ósseo foi estabelecida entre quaisquer dos três grupos tratados e o grupo controle. Entretanto, alterações sugestivas de diminuição do crescimento do fêmur e da tíbia de G4 em relação a G2 e G3, foram evidenciadas. No grupo G4 alterações histopatológicas como necroses celulares e neoformação óssea, pós-necrose, foram encontradas. CONCLUSÃO: Quando comparados os grupos tratados com o grupo controle, não há evidência estatística de estímulo ou inibição ao crescimento ósseo pela aplicação do ultra-som terapêutico. Nível de Evidência: Nível II, estudo coorte transversal.OBJECTIVES: To determine the effects of ultrasound therapy on the femur and tibia growth in young rats. METHOD: Four-week-old male Ratus Norvegicus totaling 115 animals, divided into four groups, were submitted to ultrasound therapy (0.8 MHz, fixed tube head, continuous pulse, for 10 minutes, once a day, ten times on the medial face of the right knee, with powers of 0.0 W/cm2 (group G1, 0.5 W/cm2 (group G2, 1.0 W/cm2 (group G3, and 1.5 W/cm2 (group G4. Histological slides of the epiphysis, growth plate and metaphysis and the

  11. Sensibilidade e especificidade do "California Mastitis Test" como recurso diagnóstico da mastite subclínica em relação à contagem de células somáticas

    Directory of Open Access Journals (Sweden)

    Brito José Renaldi Feitosa

    1997-01-01

    Full Text Available O "California Mastitis Test" (CMT estima o conteúdo de células somáticas no leite e é interpretado subjetivamente, estabelecendo-se escores que, na maioria dos casos, variam de 1 a 5. O escore 1 indica uma reação completamente negativa e os de 2-5 indicam graus crescentes de resposta inflamatória do úbere, sendo normalmente considerados como indicativos de mastite subclínica. Dependendo da interpretação dos escores, o CMT pode produzir resultados falso-positivos ou falso-negativos. Esse trabalho teve o objetivo de avaliar a sensibilidade e a especificidade do CMT em relação à contagem de células somáticas (CCS. Foram utilizadas 3.012 amostras de leite provenientes de 760 vacas Holandesas ou mestiças Holandês-Zebu, pertencentes a 15 rebanhos. Todas as amostras foram submetidas ao CMT e processadas para CCS em equipamento Fossomatic 90. Os valores médios de CCS (x 1.000 células/ml obtidos para os escores de CMT foram 1 (79,9, 2 (333,5, 3 (670,3, 4 (1.354,0 e 5 (4.455,6. Três opções de interpretação (doente/não-doente para o CMT foram testadas, em relação aos valores de CCS, iniciando com 100.000 células/ml: (a 1 versus 2, 3, 4, e 5; (b 1 e 2 versus 3, 4 e 5; (c 1, 2, 3 versus 4 e 5. As sensibilidades do CMT em identificar corretamente quartos mamários acima de 200.000 células/ml foram 79%, 61% e 34%, para as opções a, b e c, respectivamente. Para identificar corretamente contagens acima de 500.000 células/ml, as sensibilidades do CMT, para as opções a, b e c, foram, respectivamente: 93%, 82% e 54%. A sensibilidade do CMT em identificar quartos mamários com mastite subclínica foi adequada (acima de 80% quando a interpretação do teste foi mais rigorosa (opções a e b. A interpretação da reação 3 como negativa (opção c só alcançou sensibilidade de 80% para contagens entre 1.200.000 e 1.400.000 células/ml. As especificidades do CMT, para CCS de 200.000 e 500.000 foram, respectivamente, 90% e 80% (op

  12. Snehvides Billede som virkelighedsteater

    DEFF Research Database (Denmark)

    Krøgholt, Ida

    2015-01-01

    nyere affektforskning, der er rettet mod kunstens henvendelsesformer og virkninger (bl.a. Massumi og Deleuze), markeres der en interesseforskydning fra følelse til affekt. Det får den konsekvens, at forklaringer på hvordan kunst fungerer og virker ikke søges i tilskuerens følelsesregistreringer men...... affektive henvendelsesform, henter jeg inspiration i aktør-netværks teorien (Latour) og denne teoris materialitets- og tingsbegreb. Den kølige form for virkelighedsteater, som Snehvides Billede repræsenterer, vil ikke vække tilskuerens trang til at gribe ind i virkeligheden. Den vil snarere, via affekt...

  13. Machinima som kreativ praksis

    DEFF Research Database (Denmark)

    Frølunde, Lisbeth

    2014-01-01

    Video: Machinima som Kreativ Praksis. Videoen fortæller om de overordnede temaer i et forskningsprojekt der undersøgte nye former for online multimedie- og filmproduktion og fællesskaber med fokus på 'machinima' animation. Studiet af machinima var en del af et større dansk projekt og et nordisk f...... forskningprojekt om virtuelle verdener og teknologiudvikling, 2010-13. Videoen er præsenteret på Audiovisual Thinking nr. 7 under temaet: Den kreative økonomi....

  14. Induction of somatic embryogenesis in immature seeds of guavatree cv. Paluma Indução de embriogênese somática em sementes imaturas de goiabeira cv. Paluma

    Directory of Open Access Journals (Sweden)

    Elisa Ferreira Moura

    2009-06-01

    Full Text Available The biotechnological techniques may help solve many problems of guava culture, such as the high perishability of fruits. Somatic embryogenesis can generate highly multiplicative cell cultures and with high regenerative potential, serving as basis for genetic transformation. The aim of this work was to obtain somatic embryogenesis of guava (Psidium guajava L. cv. Paluma. Immature seeds were used, and they were inoculated in MS environment containing 400 mg L-1 of L-glutamine, 100 mg L-1 myo-inositol, 60 g L-1 sucrose, 100 mg L-1 ascorbic acid and supplemented with different types and concentrations of growth regulators. Embryogenic callus appeared after 37 days of culture in an environment containing 1.0 mg L-1 2.4-D + 2.0 mg L-1 2-ip, in 7% of the explants. After 65 days of culture, the treatment containing 0.5 mg L-1 CPA showed 20% of explants with direct embryos, while the treatment with 1 mg L-1 had 14% of explants with direct embryos and 7% of explants with embryogenic callus. In 66.6% of embryos regenerated with 0.5 mg L¹ CPA there was the formation of secondary embryos. The use of IASP and BAP, aiming embryogenesis proliferation, led to an increase in the cellular proliferation, but calli apparently lost their embryogenic potential.As técnicas biotecnológicas podem ajudar a solucionar alguns problemas do cultivo da goiabeira, como o alto perecimento dos frutos. A embriogênese somática pode gerar culturas de células altamente multiplicativas e com alto poder regenerativo, sendo base para processos de transformação genética. O objetivo deste trabalho foi obter embriogênese somática de goiabeira (Psidium guajava L. cv. Paluma. Foram utilizadas sementes imaturas, que foram inoculadas em meio MS contendo 400 mg L-1 de L-glutamina, 100 mg L-1 de mioinositol, 60 g L-1 de sacarose, 100 mg L-1 de ácido ascórbico, suplementado com diferentes tipos e concentrações de reguladores de crescimento. Calo embriogênico surgiu após 37 dias

  15. Kroppen som monitor

    DEFF Research Database (Denmark)

    Filges, Tine

    2005-01-01

    Tine Filges tager fat i de unges brug og forhold til porno, og har som en central pointe, at unge langt fra er en homogen gruppe. Der er væsentlige forskelle i unges forhold til deres krop. Dette lyder måske banalt og indlysende, men det er en pointe, der ofte glemmes i den offentlige debat om unge...... og deres kroppe. Abstract: Unges kroppe forbindes ofte med risici og farer. Vi lurer farer alle steder, og medierne er fulde af overskrifter: Fedmeepidemier. Unge med åreforkalkning. Druk. Porno. Spiseforstyrrelser. Selvskadende adfærd. I takt med at kroppen monitoreres, er den i stigende grad blevet...... koloniseret af en bekymret hær af forskere, forældre, pædagoger og terapeuter. Vi spørger ængsteligt: Vil de unge lave deres krop om livet igennem? Vil de virkelig have plastik i brysterne? Vil den næste generation tage Viagra som 18-årige? Kan unge indgå i intime relationer, når de er vokset op med porno på...

  16. Adequação da contagem de células somáticas e da contagem bacteriana total em leite cru refrigerado aos parâmetros da legislação

    Directory of Open Access Journals (Sweden)

    G.A. Bozo

    2013-04-01

    Full Text Available O objetivo deste trabalho foi adequar a qualidade do leite cru refrigerado de cinco propriedades leiteiras aos parâmetros microbiológicos e de contagem de células somáticas (CCS estabelecidos pela legislação estadual do Paraná. As propriedades leiteiras estudadas foram monitoradas durante sete meses após a implantação de boas práticas de ordenha e de recomendações quanto ao tratamento de mastites e à manutenção e higienização de equipamentos de ordenha. Antes da adoção das recomendações, a contagem bacteriana total (CBT média era de 1,36 x 10(6UFC/mL e a CCS média, de 1,87 x 10(6/mL. Todas as propriedades atingiram os padrões estabelecidos para CBT, com redução média de 93,4%. A redução de CCS foi, em média, 74,3%. Apenas três propriedades atingiram os valores estabelecidos para CCS. As demais atingiram valores muito próximos ao limite. A adequação aos padrões de CBT e CCS gerou aumento na renda mensal, em razão do pagamento por qualidade do produto, entre R$120,00 e R$828,00, de acordo com a produção de cada propriedade.

  17. DUT som didaktisk felt

    DEFF Research Database (Denmark)

    Qvortrup, Ane; Keiding, Tina B.

    2015-01-01

    undervisningsformer. [Abstract in English] The paper presents a systematic categorization of 115 papers published in the Danish Journal for Teaching and Learning in Higher Education. (DUT) from 2006 to 2013. The aim is to explore which didactic topics the journal deals with and how it contributes to the Danish...... the scholarship of teaching and learning. The categorization shows that most of the contributions deal with teaching methods. A subsequent analysis shows that the contributions almost exclusively deal with active and social teaching methods (teaching as experience and teaching as interaction)......(In Danish and English) Artiklen foretager en systematisk kategorisering og analyse af de bidrag, som har været bragt i Dansk Universitetspædagogisk Tidsskrift (DUT) fra 2006-2013. Formålet er at undersøge, hvilke didaktiske temaer tidskriftet har været optaget af og at diskutere mulige...

  18. Auto-fotografi som metode

    DEFF Research Database (Denmark)

    Mogensen, Mette

    2014-01-01

    Artiklen sætter fokus på auto-fotografi som metode i arbejdsmiljøforskningen. Den organisationsæstetiske tilgang, som metoden ofte forbindes med, udfordres med afsæt i en performativ og aktørnetværks-teoretisk position. Gennem en analyse af et enkelt auto-fotografi vises hvordan en artikulation af...

  19. Værk som handling

    DEFF Research Database (Denmark)

    Jalving, Camilla

    , er det stadig kun ved at blive en del af kunsthistoriens metode. Bogen afdækker derfor først begrebets skiftende betydninger fra J.L. Austins sprogfilosofi til Judith Butlers kønsteori og afprøver derefter, hvordan det kan bruges som metode i kunsthistorien og spores som tema i billedkunsten. Det...

  20. Forskere som nano-arkitekter

    DEFF Research Database (Denmark)

    Nielsen, Morten Muhlig; Andersen, Ebbe Sloth

    2009-01-01

    Dna er et fantastisk byggemateriale, som ud fra enkle principper kan samle sig selv til umådeligt komplicerede strukturer. Forskerne udnytter nu disse egenskaber til at lave deres egne, hjemmedesignede dna-strukturer, som kan tænkes anvendt i mange forskellige sammenhænge. Udgivelsesdato: juli...

  1. Filosofisk terapi som social atilpasning

    DEFF Research Database (Denmark)

    Sørensen, Anders Dræby

    Den dominerende psykopatologi forstår psykiske lidelser som udtryk for en patologisk utilpassethed, og psykoterapiens mål bliver normalisering gennem social og psykisk gentilpasning. Eksistentiel fænomenologi forstår lidelsen som etisk vildfarelse i det normale, og terapiens knytter an begreber o...

  2. Variação da contagem de células somáticas em vacas leiteiras de acordo com patógenos da mastite Somatic cell counts variation in dairy cows according to mastitis pathogens

    Directory of Open Access Journals (Sweden)

    G.N. Souza

    2009-10-01

    Full Text Available Avaliou-se o efeito de patógenos da mastite sobre a contagem de células somáticas (CCS em leite. Foram coletadas 3.987 amostras de leite de 2.657 animais oriundos de 24 rebanhos leiteiros localizados nos estados do Rio de Janeiro e Minas Gerais. As amostras de leite foram usadas para CCS e identificação de patógenos da mastite. Estatísticas descritivas, teste T para amostras independentes e modelo linear generalizado foram usados para análise dos dados. O modelo linear generalizado identificou os efeitos de rebanho, animal dentro de rebanho, ordem de parto, estação do ano e infecção intramamária causada por Streptococcus agalactiae e Streptococcus spp. que não S. agalactiae como significativos na variação da CCS. O efeito de animal dentro de rebanho foi maior que o efeito de rebanho. S. agalactiae foi o patógeno responsável pelo maior aumento da CCS em vacas e apresentou em média 1.520.000 células/mL. Foi observado efeito específico dos patógenos na variação da CCS.The influence of mastitis pathogens on variation of milk somatic cell count (SCC was evaluated. Three thousand nine hundred eighty-seven milk samples were colected from 2,657 dairy cows in 24 herds located in the states of Minas Gerais and Rio de Janeiro. The milk samples were used to SCC and identification of mastitis pathogens. Descriptive statistics, T test for independent samples, and generalized linear model were used to data analysis. The generalized linear model identified the effects of herd, animal within herd, parity, year season, intramammary infection, and infection caused by Streptococcus agalactiae and Streptococcus spp. except S. agalactiae as significant on SCC variation. The effect of animal within herd was higher than the effect of herd. S. agalactiae was the pathogen responsible for higher SCC increasing and presented the average of 1,520,000 cells/mL. The specific effect on SCC variation was observed in the study.

  3. Kulturen som krænkelsens virkelighed

    DEFF Research Database (Denmark)

    Brock, Steen

    2006-01-01

    En analyse af forholdet mellem natur og kultur i relation til en opfattelse af kultur, som har sin oprindelse i Cicero, og som har sin genklang i moderne tænkere som Goethe, Wittgenstein, Cavell og E. Wolfgang Orth.......En analyse af forholdet mellem natur og kultur i relation til en opfattelse af kultur, som har sin oprindelse i Cicero, og som har sin genklang i moderne tænkere som Goethe, Wittgenstein, Cavell og E. Wolfgang Orth....

  4. Contagem de células somáticas e produção leiteira em cabras Saanen estressadas via aplicação de ACTH Somatic cell count and milk production of Saanen goats stressed via application of ACTH

    Directory of Open Access Journals (Sweden)

    Ana Paula Rodrigues Gaiato

    2012-05-01

    Full Text Available Avaliou-se neste estudo o efeito do estresse, via administração de ACTH (hormônio adrenocorticotrófico, sobre a quantidade e qualidade do leite produzido e a indicação de estresse pela alteração no nível de cortisol. Assim, 12 cabras lactantes foram distribuídas em dois grupos: seis animais receberam aplicação de 0,06 UI de ACTH/kg de PV (desafiadas e seis receberam solução placebo (controle, todas via intravenosa. O desafio ocorreu ao longo da lactação, com aplicação do protocolo aos 30, 60, 120 e 180 dias do início da lactação, avaliando-se em cada data os níveis de cortisol 30 minutos antes, no ato da aplicação, 60, 120 e 300 minutos depois. A produção leiteira foi mensurada diariamente durante 270 dias e, a cada 20 dias, o leite foi colhido para contagem de células somáticas (CCS pelo método direto. Os teores de cortisol mensurados em -30 e 0 minuto antes da aplicação de ACTH foram baixos e semelhantes entre os grupos. Entretanto, a partir de 60 minutos, constatou-se efeito da aplicação de ACTH, com teor de cortisol de 61,37±6,65 versus 5,47±1,21 ng/mL e de 51,17±10,21 versus 4,67±1,21 ng/mL aos 120 minutos. Aos 300 minutos, o cortisol retornou ao nível basal. Não houve diferença na produção de leite, no teor de proteína e de gordura do leite, cujos valores nos grupos ACTH e Placebo foram 1,37±0,59 e 1,38±0,63 kg de leite, respectivamente. A contagem de células somáticas não foi influenciada pelo estresse e apresentou valores situados na faixa indicada para animais sadios. Constatou-se estresse pontual em decorrência da aplicação de ACTH, porém sem alterações de natureza quantitativa e qualitativa do leite produzido, e isso indica que atividades de manejo que estressam os animais pontualmente não trazem prejuízos ao sistema produtivo.The objective of this study was to analyze the stress effect, via administration of ACTH (adrenocorticotropic hormone, on quantity and quality of milk

  5. Determinação do valor de referência para o cortisol basal sérico em população pediátrica sem doença adrenal

    OpenAIRE

    Cristina Botelho Barra

    2012-01-01

    A medida do cortisol basal reflete a atividade hipotalâmica-hipofisária-adrenal. É utilizada na avaliação da integridade da resposta do eixo, principalmente em pacientes submetidos a longos períodos de tratamento glicocorticoide, por apresentarem maior risco de supressão adrenal. Em pediatria, a supressão adrenal deve ser sempre considerada em crianças que receberam doses suprafisiológicas de glicocorticoides por mais de duas semanas. Nessas condições, há risco de crise adrenal mesmo em vigên...

  6. Interaktionsforskning som metode i erhvervsforskningen

    DEFF Research Database (Denmark)

    Goldschmidt, Lars; Elkjær-Larsen, Jens Kr.

    aktionsforskningen er ikke konsolideret som én fælles forskningstradition. Der er derimod udviklet en række forskningsmetodiske tilgange såsom: Aktionsforskning, Action science,Sociologisk fantasi, Bruger/borger involvering i udviklingsprojekter, Dialogforskning, Reflectivepractice, Action learning, Appreciative...... inquiry, Communities of Inquiry in Communities ofpractice, Clinical inquiry (Baskerville 1996). Metoderne er udviklet i relation til det felt eller problemstilling, som forskergrupperne var engagerede i, og kun enkelte er tænkt ind i enerhvervsforskningskontekst. Denne mangfoldighed har ført til, at det...

  7. The barley <em>HvNAC6em> transcription factor affects ABA accumulation and promotes basal resistance against powdery mildew

    DEFF Research Database (Denmark)

    Chen, Yan-Jun; Perera, Venura; Wagner, Michael

    2013-01-01

    Barley HvNAC6 is a member of the plant-specific NAC (NAM, ATAF1,2, CUC2) transcription factor family and we have shown previously that it acts as a positive regulator of basal resistance in barley against the biotrophic pathogen Blumeria graminis f. sp. hordei (Bgh). In this study, we use a trans...

  8. Rwanda - eller hvor som helst

    DEFF Research Database (Denmark)

    Sonne, Charlotte Kærgaard; Weis, Rikke Lise

    2010-01-01

    Sundhedspersonalets rolle under konflikter er ofte et springende punkt, ikke mindst fordi intellektuelle og hermed også uddannet sundhedspersonale ikke sjældent er blandt ofrene i konflikten, som vi har set det med eksemplet i Rwanda.......Sundhedspersonalets rolle under konflikter er ofte et springende punkt, ikke mindst fordi intellektuelle og hermed også uddannet sundhedspersonale ikke sjældent er blandt ofrene i konflikten, som vi har set det med eksemplet i Rwanda....

  9. Estimativa da gordura de cobertura ao abate, por ultra-som, em tourinhos Brangus e Nelore Prediction of backfat at slaughter, by ultrasound, in Nellore and Brangus young bulls

    Directory of Open Access Journals (Sweden)

    Saulo da Luz e Silva

    2004-04-01

    Full Text Available O objetivo deste trabalho foi verificar a viabilidade da utilização da ultra-sonografia para estimar a espessura de gordura na carcaça (EGSC no momento do abate. Foram confinados 24 machos inteiros Brangus e 24 Nelore com dietas contendo 20, 40, 60 ou 80% de concentrado. A área de olho de lombo (AOLU e a espessura de gordura (EGSU entre a 12ª e a 13ª costelas e a espessura de gordura sobre o músculo Biceps femoris (EGPU, foram obtidas com equipamento de ultra-som PieMedical Scanner 200 Vet com transdutor linear de 178 mm e guia acústica, a cada intervalo de aproximadamente 28 dias. Após 142 dias de confinamento, os animais foram abatidos e 24 h após foi obtida a EGSC. As correlações entre EGSU e EGSC foram de 0,19, 0,64, 0,74, 0,78, 0,82, 080 e 0,86, quando obtidas aos 0, 26, 53, 84, 109, 125 e 142 dias de confinamento. Equações de regressão múltipla entre raças para estimar a EGSC apresentaram R² = 0,10 e Sy,x = 2,04 quando realizadas 142 dias antes do abate e R² = 0,78 e Sy,x = 0,10 imediatamente antes do abate. Medidas de ultra-som podem ser úteis para classificar grupos de animais para abate em igual acabamento.The objective of this work was to verify the usefullness of ultrasound to estimate the carcass backfat thickness (EGSC at slaughter. Twenty four Brangus and 24 Nelore, intact males, were fed with diets containing 20, 40, 60 or 80% of concentrate. Ribeye area (AOLU and backfat thickness (EGSU between 12ª and 13ª ribs and the fat thickness over Biceps femoris muscle (EGPU were collected with a PieMedical Scanner 200 Vet equipment, with linear array transducer of 178 mm coupled with standoff guide, on intervals of approximately 28 days. After 142 days on fed, animals were slaughtered and the carcass backfat thickness (EGSC was taken, 24 hours after. The correlations between EGSU and EGSC were 0.19, 0.64, 0.74, 0.78, 0.82, 0.80 and 0.86 when taken at 0, 26, 53, 84, 109, 125 and 142 days on fed. Multiple regression

  10. Discursos em disputa: uma leitura alternativa acerca dos dilemas da ação internacional na Somália durante a década de 1990

    Directory of Open Access Journals (Sweden)

    Marta Regina Fernandez Y Garcia Moreno

    2014-01-01

    Full Text Available O artigo aborda os dilemas enfrentados pelos atores internacionais nas operações de paz levadas a cabo na Somália na década de 1990. Busca-se evidenciar as narrativas divergentes articuladas pelos Estados Unidos e pelas Nações Unidas vis-à-vis o "Outro" somali. Sugere-se que os principais dilemas experimentados pela ONU e pelos Estados Unidos na Somália não foram de natureza técnica, concernente a problemas de coordenação entre as principais forças envolvidas, como usualmente se argumenta. Diferentemente, argumenta-se que existiu uma disputa de natureza política entre os Estados Unidos e a ONU na Somália, amparada por discursos distintos sobre o "Outro" somali.

  11. Avaliação do ombro em pacientes portadores de espondilite anquilosante por meio de ultra-som Evaluation of the shoulder in patients with ankylosing spondylitis with ultrasound

    Directory of Open Access Journals (Sweden)

    Ciro Yoshida Junior

    2008-04-01

    Full Text Available OBJETIVO: Descrever as principais alterações nos ombros de pacientes portadores de espondilite anquilosante (EA por meio de ultra-som (US e correlacionar os achados de imagem com a idade e o tempo de doença. MÉTODOS: Foram selecionados 35 pacientes com diagnóstico clínico de EA. Os pacientes foram submetidos a exame de ultra-sonografia dos ombros, sendo avaliados os tendões do manguito rotador quanto à sua ecotextura e espessura, o tendão do bíceps, a articulação acromioclavicular, os tubérculos umerais, a bursa subacromial-subdeltóidea, e a face posterior da articulação glenoumeral. Foram colhidos dados de tempo de doença, presença de dor nos ombros e freqüência das alterações das estruturas avaliadas. Os dados foram comparados com a idade e o tempo de doença, utilizando-se teste qui-quadrado e teste t de Student. RESULTADOS: Foi observada prevalência de 20% de alterações no manguito rotador, sendo 10% de tendinose/calcificação tendínea e 10% de rupturas tendíneas. A espessura média dos tendões do manguito rotador foi de 5,8 mm. As alterações ósseas nos tubérculos do úmero ocorreram em 84,3% dos ombros e as alterações acromioclaviculares em 54,3% dos ombros. CONCLUSÃO: Não há modificação da espessura dos tendões do manguito rotador relacionadas com o tempo de doença. Os principais achados de US, que se correlacionam com o tempo de doença na EA, são alterações ósseas nos tubérculos umerais e na articulação acromioclavicular. Não houve relação entre tempo de doença e presença de lesão tendínea.PURPOSE: To describe shoulder involvement and its prevalence with ultrasound in patients with ankylosing spondylitis and correlate the findings with age and duration of disease. METHODS: Ultrasound scans of both shoulders were performed in thirty five selected patients with clinical diagnosis of ankylosing spondylitis. Rotator cuff texture and thickness were evaluated as well as the biceps tendon

  12. Queer eller manden som ideal

    DEFF Research Database (Denmark)

    Sjørup, Karen

    2016-01-01

    Forestillingen om barnet som den i kønslig forstand renvaskede tavle er fejlagtig og selvmodsigende. I stedet bør forældre og samfund give børn ballast til at begive sig ud i livet uden for mange normative direktiver.......Forestillingen om barnet som den i kønslig forstand renvaskede tavle er fejlagtig og selvmodsigende. I stedet bør forældre og samfund give børn ballast til at begive sig ud i livet uden for mange normative direktiver....

  13. Krisekommunikation som model for virksomhedsretorik?

    DEFF Research Database (Denmark)

    Rasmussen, Rasmus Kjærgaard

    2017-01-01

    kommunikativt konstitueret fænomener. Her argumenterer jeg for en analytisk syntese mellem framingteorier og det såkaldte CCO-paradigme, til sammen kan hjælpe krisekommunikationsteorierne med at slippe den aprioriske tilgang til kriser ved at forstå såvel kriser og organisationer som resultatet af kommunikative...

  14. Medborgerskab som skolefag i Malaysia

    DEFF Research Database (Denmark)

    Tiemensma, Britt Due; Hald, Anne Mette

    2009-01-01

    Globalisering og internationalisering indgår med selvfølgelighed i uddannelsessektorens begrebsverden. Men hvad mener vi egentlig, når vi bruger begreberne? Benyttes de som abstrakte talemåder, for at vi skal kunne forholde os til uoverskueligheden i den aktuelle udvikling, eller kan begreberne k...

  15. Interaktiv forskning som samarbejdsdrevet innovation

    DEFF Research Database (Denmark)

    Martinez, Laia

    2012-01-01

    Hovedformålet med denne artikel er at formidle nogle af de metodiske overvejelser, som jeg har gjort mig om samspillet mellem forskere og praktikere i forbindelse med gennemførelsen af mit Ph.d.-projekt om innovationsledelse i danske kommuner....

  16. Kina som stormagt i Arktis

    DEFF Research Database (Denmark)

    Nørup Sørensen, Camilla Tenna

    I slutningen af januar 2018 offentliggjorde Kina sin længe ventede Arktisstrategi. Den står som en foreløbig kulmination på de senere års udvikling af et mere selvsikkert, proaktivt og sofistikeret kinesisk diplomati i Arktis. Beijing har intensiveret bestræbelserne på at etablere stærke og...

  17. Med det sociale som designmateriale

    DEFF Research Database (Denmark)

    Brandt, Eva; Binder, Thomas

    2016-01-01

    Samarbejde, samskabelse og social nysgerrighed er i dag en præmis for den nyskabende designer. Det sociale er det nye designmateriale som unge designere giver sig i kast med når f.eks. Emmy Linde samarbejder med plejehjemsbeboere, deres pårørende, plejepersonale og fysioterapeuter for at designe ...

  18. Fokusgruppeinterview som led i en evalueringsproces

    DEFF Research Database (Denmark)

    Andersen-Mølgaard, Hanna; Harrit, Ole

    2006-01-01

    Teoretiske begrundelser og perspektiver, responsiv-konstruktivistisk evaluering, fokusgruppeinterview som led i BIKVAmodellen, eksempler, vurdering og perspektivering......Teoretiske begrundelser og perspektiver, responsiv-konstruktivistisk evaluering, fokusgruppeinterview som led i BIKVAmodellen, eksempler, vurdering og perspektivering...

  19. Calcificação nos núcleos da base na tomografia computadorizada: correlação clínica em 25 pacientes consecutivos Basal ganglia calcification on computed tomography: clinical characteristics in 25 patients

    Directory of Open Access Journals (Sweden)

    Glória Maria A.S. Tedrus

    2006-03-01

    Full Text Available Analisamos os aspectos clínicos de 25 pacientes consecutivos que apresentaram calcificação nos núcleos da base na tomografia computadorizada (TC de crânio. Esta ocorreu em 0,68% de todos os exames realizados no período. Vinte e três pacientes apresentavam condições clínicas diversas, a saber: cefaléia em 7 casos, acidente vascular cerebral em 5, síndrome extrapiramidal em 2, processo expansivo cerebral em 2, epilepsia, retardo do desenvolvimento neuropsicomotor, demência e trauma de crânio em um caso cada ou outras condições neurológicas em 3. Não havia sintomas neurológicos em 2 casos. Em 15 pacientes (60,0% havia, além da calcificação dos núcleos da base, outras alterações na TC. Correlação clínica foi observada apenas com as outras alterações da TC e não com a calcificação dos núcleos da base, corroborando a hipótese de que esta possa ser um achado incidental.Twenty-five patients presenting basal ganglia calcification were assessed. This finding comprised 0.68% of all skull CT scan carried out during the period. Two patients were neurologically asymptomatic and 23 presented a variety neurological disorders - headache (7 patients, stroke (5 patients, extrapyramidal syndromes (2 patients, tumor (2 patients, epilepsy (1 patient, mental retardation (1 patient, dementia (1 patient, cranial trauma (1 patient, other neurological conditions (3 patients - or were asymptomatic from the neurological point of view (2 patients. Findings in the CT scan other than the basal ganglia calcification were observed in 15 (60% patients. There was a clinical-CT scan correlation in these cases but not in those in which the basal ganglia calcification was an isolated finding. This study highlights the fact that basal ganglia calcification is often a nonspecific finding on CT scan and that it may not be possible to establish a clinical-pathological correlation between them.

  20. Contagem de células somáticas e produção de leite em vacas holandesas confinadas Somatic cells count and milk yield in confined holstein cows

    Directory of Open Access Journals (Sweden)

    Arlei Coldebella

    2004-06-01

    Full Text Available A relação entre contagem de células somáticas do leite (CCS e produção de leite é objeto de estudo de inúmeras pesquisas em diversos países, porém, no Brasil a literatura a esse respeito é escassa. Desse modo, o objetivo do presente trabalho é verificar se as perdas na produção de leite devidas ao aumento da CCS são proporcionais à produção, ou absolutas, independendo desta, e a partir de que valor de CCS elas começam a ser evidentes. Para o estudo foram utilizadas 13.725 observações, colhidas mensalmente de seis rebanhos, no período de janeiro de 2001 a junho de 2002. O modelo de análise, para curva de lactação, foi baseado na função gama incompleta, considerando os efeitos de ordem de lactação, rebanho e época do parto. A CCS foi incluída nesse modelo de duas formas: como fator multiplicativo (representando perdas relativas e como fator aditivo (representando perdas absolutas. A escolha do melhor modelo foi baseada no critério de informação de Schwarz (BIC. Concluiu-se que as perdas são absolutas, evidentes a partir de 17.000 células/mL e, para cada aumento de uma unidade na escala do logaritmo natural a partir desse valor, estimam-se perdas de 238 e 868 mL/dia para primíparas e multíparas, respectivamente.The relationship between milk somatic cells count (SCC and milk yield has been the aim of countless researches in several countries; however, in Brazil, the literature related to this subject is scarce. Therefore, the objective of this study is to verify if the losses in milk yield due to SCC increase are proportional to the yield, or absolute (independent of it and starting from which SCC, the losses become evident. For this study, 13.725 observations were used, collected monthly from 6 different herds, from January/2001 up to June/2002. The analysis model, for lactation curve, was based upon the incomplete gama function, considering the effects of lactation order, herd and calving season. The SCC

  1. Indução de embriogênese somática em genótipos de batata-doce Induction of somatic embryogenesis in sweet potato genotypes

    Directory of Open Access Journals (Sweden)

    Janaina S Magalhães

    2006-03-01

    Full Text Available A diferenciação e o desenvolvimento de embriões somáticos foram observados em 15 genótipos de batata-doce a partir de explantes de ápices caulinares com um ou dois primórdios foliares. A embriogênese foi induzida utilizando o meio composto de sais minerais MS e vitaminas, 3% de sacarose, 0,2% de phytagel, suplementado com 2,4-D (0,0; 0,5; 1,0 e 2,0 mg/L. As culturas foram mantidas no escuro à temperatura de 27ºC. A adição de 2,4-D foi necessária para a indução de calo embriogênico nos genótipos '92', '94', '184', '188', '319', '370', '374', '442', '449', '5491, '594', '645', 'PI3138463', 'White Star' e 'Jewel'. Os clones '169', '202', '605', '633' e '643' não responderam à indução de calo embriogênico. Os calos embriogênicos apresentaram a coloração amarelo claro, textura compacta e granular, enquanto que os calos não embriogênicos apresentaram coloração hialina e consistência friável. Os calos formaram-se na região periférica dos explantes. Nas condições estabelecidas, melhor produção de calo embriogênico foi obtida com 2,0 mg/L de 2,4-D. A transferência desses calos para meio sem 2,4-D favoreceu o desenvolvimento dos embriões para os estádios cordiforme, torpedo e cotiledonar.The differentiation and development of somatic embryos were observed in 15 genotypes of sweet potato using shoot tip explants with one or two leaf primordia. Somatic embryogenesis was induced using MS media and vitamins, 3% sucrose, 0,2% phytagel, supplemented with 2,4-D (0,0; 0,5; 1,0 and 2,0 mg/L. The cultures were maintained in the dark at 27ºC. The addition of 2,4-D was necessary for embryogenic callus induction in the genotypes '92', '94', '184', '188', '319', '370', '374', '442', '449', '549', '594', '645', 'PI3138463', 'White Star' and 'Jewel'. Clones '169', '202', '605', '633' and '643' did not respond to embryogenic callus induction. Embryogenic callus showed a yellow and opaque color, compact and granular texture

  2. Clinical and histopathological profile of basal cell carcinoma in a population from Criciúma, Santa Catarina, Brazil Perfil clínico e histopatológico do carcinoma basocelular em amostra populacional de Criciúma, SC, Brasil

    Directory of Open Access Journals (Sweden)

    Letícia Pangendler Peres

    2012-08-01

    Full Text Available Basal cell carcinoma is a local, invasive epidermal neoplasia, the most common type of which is nodular basal cell carcinoma. The objective of the present study was to evaluate the occurrence of basal cell carcinoma, characterizing its distribution in accordance with patients' age, gender, the site of the lesion and its histopathological characteristics. Anatomopathology reports of cases of basal cell carcinoma diagnosed in Criciúma, Santa Catarina, Brazil between June 2005 and June 2007 were analyzed. A descriptive, observational, cross-sectional study was conducted. The majority of patients were females over 40 years of age. Most of the tumors were of the nodular type and were situated on the face. There was ulceration in 27.5%, infiltration in 24.5% and invasion of the deep dermis in 61.8%. Local data must be evaluated in order to emphasize the importance of early diagnosis.O carcinoma basocelular é uma neoplasia epidérmica invasiva local, cujo tipo mais frequente é nódulo-ulcerativo. O objetivo foi estudar a ocorrência de CBC, caracterizando sua distribuição segundo idade, sexo, localização e características histopatológicas. Analisaram-se laudos anatomopatológicos de CBC, diagnosticados em Criciúma/SC, entre junho de 2005 e junho de 2007. Elaborou-se um estudo descritivo, observacional e transversal. Predominou após os 40 anos, no sexo feminino, do tipo nodular e localizado na face. Houve ulceração em 27,5%, infiltração em 24,5%, invasão de derme profunda em 61,8%, entre outros. É necessário conhecer dados locais para reforçar a importância do diagnóstico precoce.

  3. Sintomas somáticos de depressão em pacientes portadores de retocolite ulcerativa idiopática Síntomas somáticos de depresión en pacientes con rectocolitis ulcerosa idiopática Somatic symptoms of depression in patients with idiopathic ulcerative colitis

    Directory of Open Access Journals (Sweden)

    Taís de Souza Serafim

    2009-06-01

    Full Text Available OBJETIVO: Identificar os sintomas depressivos mais freqüentes entre portadores da doença Retocolite Ulcerativa Idiopática (RCUI e compará-los a um grupo de controle. MÉTODO: A amostra compôs-se de 100 indivíduos adultos portadores de RCUI que freqüentavam o Ambulatório de Doenças Inflamatórias do Cólon do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo que foram comparados a 100 indivíduos isentos da doença. Após os procedimentos éticos devidos todos responderam ao Inventário de Depressão de Beck. RESULTADOS: Dos 21 sintomas depressivos, seis mostraram valores estatísticos significativos para: distorção da imagem corporal, inibição para o trabalho, fadiga, perda do apetite, preocupação somática e diminuição de libido. CONCLUSÃO: Verificou-se que os doentes apresentaram com mais freqüência sintomas depressivos da esfera somática quando comparados ao grupo de controle. A similaridade dos sintomas entre a doença e os sintomas depressivos faz com que os doentes sejam freqüentemente subdiagnosticados.OBJETIVO: Identificar los síntomas depresivos más frecuentes entre portadores de la enfermedad Rectocolitis Ulcerativa Idiopática (RCUI y compararla a un grupo de control. MÉTODO: La muestra estuvo compuesta de 100 individuos adultos portadores de RCUI que frecuentaban El Consultorio Externo de Enfermedades Inflamatorias del Colon del Hospital de las Clínicas de la Facultad de Medicina de la Universidad de Sao Paulo que fueron comparados con 100 individuos libres de la enfermedad. Después de los respectivos procedimientos éticos todos respondieron al Inventario de Depresión de Beck. RESULTADOS: De los 21 síntomas depresivos, seis mostraron valores estadísticos significativos para: distorsión de la imagen corporal, inhibición para el trabajo, fatiga, pérdida del apetito, preocupación somática y disminución de la libido. CONCLUSIÓN: Se verificó que los enfermos presentaron

  4. Expressão de metaloproteinases de matriz e de seus inibidores teciduais em carcinomas basocelulares Expression of matrix metalloproteinasis and their tissue inhibitors in basal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Rosy Iara Maciel de Azambuja Ribeiro

    2008-04-01

    Full Text Available INTRODUÇÃO: Aproximadamente 80% das neoplasias malignas de pele não-melanomas são carcinomas basocelulares (CBC. Apesar das raras metástases, esses tumores são localmente agressivos. As metaloproteinases de matriz (MMPs, especialmente as MMP-2 e 9, são importantes no processo de invasão. Em contrapartida, os inibidores teciduais das MMPs (TIMPs têm como principal função a inibição dessas enzimas. OBJETIVO: Investigar a associação de variáveis clinicopatológicas de pacientes portadores de CBC com a expressão de MMP-2, MMP-9, TIMP-1 e TIMP-2. MATERIAL E MÉTODOS: Foram selecionados 31 casos de CBC, sendo então obtidos, retrospectivamente, os dados referentes a idade, sexo e tamanho da lesão. Cortes histológicos das lesões foram submetidos a reação imuno-histoquímica pela técnica estreptavidina-biotina-peroxidase para detecção dos antígenos de interesse. Índices de imunomarcação foram construídos e comparados com os dados previamente obtidos. RESULTADOS: Observou-se correlação significativa entre idade e tamanho da lesão (R = 0,532; p = 0,008. Não foram observadas correlações significativas entre as outras variáveis e a expressão imuno-histoquímica dos antígenos de interesse. CONCLUSÃO: A expressão das metaloproteinases e de seus inibidores teciduais não parece ser influenciada pelos parâmetros investigados. Estudos adicionais são necessários para melhor compreensão de sua associação com o comportamento biológico do CBC.INTRODUCTION: Approximately 80% of non-melanoma skin neoplasias are basal cell carcinomas (BCC. Although metastasis is rare, BBC carcinomas are locally aggressive tumors. Matrix metalloproteinases (MMPs, mainly MMP-2 and MMP-9, play an important role on the invasion process. On the other hand, tissue inhibitors of MMPs (TIMPs have the main function of inhibiting these enzymes. OBJECTIVE: To investigate the association of clinical-pathological variables of BCC patients with the

  5. Aumento da incidência de carcinoma basocelular em hospital universitário: 1999 a 2009 Increase in the incidence of basal cell carcinoma in a university hospital between 1999 and 2009

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    Juliano Vilaverde Schmitt

    2011-04-01

    Full Text Available A incidência do carcinoma basocelular vem aumentando em todos os países. Realizou-se estudo ecológico de 5169 laudos de carcinoma basocelular, da FMB-Unesp, entre janeiro/1999 e dezembro/2009. O incremento médio da incidência para o período foi de 90,6%, projetando-se um diagnóstico para cada 15 pacientes encaminhados à dermatologia. Tal tendência se manteve, mesmo quando indexada pelo número de laudos histopatológicos, movimento hospitalar, atendimentos da dermatologia e população de Botucatu.The incidence of basal cell carcinoma is increasing worldwide. An ecological study was conducted using the pathology reports from 5169 cases of basal cell carcinoma diagnosed at the Botucatu School of Medicine, Universidade Estadual Paulista Julio de Mesquita Filho (UNESP between January 1999 and December 2009. The mean increase in the incidence of basal cell carcinoma over this period was 90.6%, suggesting that one case of basal cell carcinoma could be expected for every 15 patients referred to dermatology. This trend was also found when the incidence was indexed according to the absolute number of histopathology exams, the total number of hospital consultations, the total number of dermatological consultations and the population of the town of Botucatu

  6. Embriogênese somática direta em explantes foliares de Coffea arabica L. cv. acaiá cerrado: efeito de cinetina e ácido giberélico Direct somatic embryogenesis in Coffea arabica L. cv. Acaiá Cerrado: kinetin and giberelic acid effects

    Directory of Open Access Journals (Sweden)

    Alba Regina Pereira

    2007-04-01

    Full Text Available Objetivou-se estudar o efeito da cinetina, GA3 e ANA na indução in vitro de embriões somáticos de cafeeiro pela via direta. Segmentos foliares retirados de plântulas cultivadas in vitro foram inoculados em meio de cultura 'MS' com 50% dos sais contendo as seguintes combinações de cinetina (0; 1; 2; 4 e 8 mg L-1 e GA3 (0; 2,5; 5; 10 e 20 mg L-1. Os meios de cultura utilizados tiveram pH ajustado para 5,8 ± 1 antes de serem autoclavados. O experimento foi mantido em sala de crescimento a 25 ± 1ºC. Avaliou-se número total de embriões somáticos, o número de embriões cotiledonares, o número de embriões torpedo e a média dos comprimentos dos embriões. A ação combinada entre cinetina, GA3 e ANA estimulou a indução de embriões somáticos pela via direta. O maior comprimento de embriões foi observado quando se utilizou 8 mg L-1 de cinetina e 8,0 mg L-1 de ANA ou 17 mg L-1 de GA3 e 8,0 mg L-1 de ANA isoladamente.It was aimed to study kinetin, GA3 and ANA effects in the in vitro induction of direct somatics embryos. Leaf segments withdrawn from plantlets in vitro were inoculated in 'MS'50% containing the following combination of kinetin (0; 1; 2; 4 and 8 mg L-1 and GA3 (0; 2,5; 5; 10 and 20 mg L-1. The culture media utilized had their pH adjusted to 5,8 ± 1 before being autoclaved. The experiment was carried out growth room at 25 ± 1ºC. Total number of embryos, number of embryos cotiledonar, number of embryos of torped and length of embryo were evaluated. The combination between kinetin and GA3 promoved induction of embryos. The use of kinetin 8 mg L-1 and GA3 17 mg L-1 not associate in medium with 8,0mg L-1 of ANA, promoter higher rates in vitro.

  7. E-tiviteter som eksamensform

    Directory of Open Access Journals (Sweden)

    Anette Grønning

    2011-12-01

    Full Text Available Med udgangspunkt i faget "Digital kommunikation på arbejde" præsenterer og diskuterer denne artikel en række anvendte digitale eksamensformer (e-tiviteter. E-tiviteterne er udarbejdet på baggrund af Gilly Salmons 5-fase-model og e-tivitetskoncept. Den anvendte e-læringsplatform er Blackboard, som de studerende og underviseren kender i forvejen. I artiklen præsenteres fagets e-tiviteter og undervisningsforløbet med e-tiviteter som eksamensform diskuteres. En række fordele og ulemper ved at veksle mellem offline- og online-aktiviteter (blended learning bliver behandlet. Det konkluderes, at de studerendes engagement og motivation kan øges ved at koble e-tiviteter sammen med eksamensformen "80% tilstedeværelse og aktiv deltagelse". Desuden fremhæves det, at aktivitetsniveauet mellem lektionerne og forberedelsesomfaget øges, ligesom de studerende motiveres til higher order thinking ved fx at tage ansvar for egen læring, udføre analyse og indgå i processen med kritisk refleksion. Endelig muliggør online-forløbet, at hele processen dokumenteres i faget til gavn for både underviser og studerende.

  8. Basal Cell Carcinoma

    Science.gov (United States)

    ... Kids’ zone Video library Find a dermatologist Basal cell carcinoma Overview Basal cell carcinoma: This skin cancer ... that has received years of sun exposure. Basal cell carcinoma: Overview Basal cell carcinoma (BCC) is the ...

  9. Múltiplos carcinomas basocelulares na região pubiana em uma paciente fototipo IV: relato de caso Multiple basal cell carcinomas in the pubic area in a patient with skin type IV: case report

    Directory of Open Access Journals (Sweden)

    Cristiani Banhos Ferreira

    2011-06-01

    Full Text Available O carcinoma basocelular é a neoplasia maligna cutânea mais comum em humanos, localizando-se, frequentemente, em áreas expostas e em indivíduos de pele clara. Relata-se o caso de uma paciente de 62 anos, faiodérmica, com múltiplas lesões de bordas discretamente elevadas, eritemato-acastanhadas na região pubiana, cujo diagnóstico clínico foi carcinoma basocelular pigmentado, confirmado através do estudo histopatológico. A imunoistoquímica das lesões foi negativa para a pesquisa de papiloma vírusBasal cell carcinoma is the most common type of malignant cutaneous neoplasm in humans, being more frequently located in exposed areas and in fair-skinned individuals. It is reported the case of a 62-yearold female patient, brown-skinned ,with multiple lesions with edges slightly raised, reddish-brown in the pubic region, whose clinical diagnosis was pigmented basal cell carcinoma, confirmed by histopathology. Immunohistochemistry of the lesions was negative for the detection of papilloma virus

  10. Evaluering som kvalitetsstøtte og mål som guide

    DEFF Research Database (Denmark)

    Levinsen, Karin Tweddell; Sørensen, Birgitte Holm

    2017-01-01

    Dette kapitel omhandler sammenhængen mellem det didaktiske design og evalueringspraksisser som aktivite der understøtter elevernes læring både som proces og produkt. Først gøres der rede for de anvendte begreber, og der argumenteres for, at formative og summative evalueringer kan forstås som...

  11. Lipoproteína (a está associada com níveis basais de insulina em pacientes com Diabetes Mellitus tipo 2 Lipoproteína (a está asociada a niveles basales de insulina en pacientes con Diabetes Mellitus tipo 2 Lipoprotein (a is associated with basal insulin levels in patients with type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Syed Shahid Habib

    2009-07-01

    Full Text Available FUNDAMENTO: Ainda não foi claramente estabelecido se a resistência/deficiência insulínica leva diretamente à aterogênese ou através de sua associação com outros fatores de risco como os níveis de lipoproteína (a[Lp(a]. OBJETIVO: O objetivo do estudo foi estabelecer a relação entre os níveis basais de insulina, lípides e lipoproteína (a em pacientes com diabetes mellitus (DM tipo 2. MÉTODOS: Amostras de sangue foram colhidas em jejum e os níveis de insulina, lipoproteína (a, colesterol total (CT, triglicérides (TG, lipoproteína de baixa densidade (LDL-C, lipoproteína de alta densidade (LDL-C, glicose e hemoglobina glicada (HbA1c foram medidos em 60 pacientes com DM tipo 2 e 28 indivíduos saudáveis. Nós dividimos os pacientes em dois grupos baseados nos níveis basais de insulina: > 10 µIU/ml e 10 µIU/ml comparados com aqueles que apresentavam insulina basal FUNDAMENTO: Todavía no se aclaró totalmente si la resistencia/deficiencia insulínica lleva directamente a la aterogénesis o a través de su asociación con otros factores de riesgo como los niveles de lipoproteína (a [Lp(a]. OBJETIVO: : El objetivo del estudio fue establecer la relación entre los niveles basales de insulina, lípidos y lipoproteína (a en pacientes con diabetes mellitus (DM tipo 2. MÉTODOS: Se extrajeron muestras de sangre en ayuno y se determinaron los niveles de insulina, lipoproteína (a, colesterol total (CT, triglicéridos (TG, lipoproteína de baja densidad (LDL-C, lipoproteína de alta densidad (LDL-C, glucosa y hemoglobina glicosilada (HbA1c en 60 pacientes con DM tipo 2 y 28 individuos sanos. Dividimos a los pacientes en dos grupos basados en los niveles basales de insulina: > 10 µIU/ml y 10 µIU/ml comparados con aquellos que presentaban insulina basal BACKGROUND: It has not been clearly established whether insulin resistance/deficiency leads directly to atherogenesis or through its association with other risk factors such as

  12. Kaposis sarkom tolket som haematom

    DEFF Research Database (Denmark)

    Balle, Jesper R; Hasselager, Thomas

    2010-01-01

    Kaposi's sarcoma is a frequent skin cancer in HIV-positive patients, but is relatively uncommon in HIV-negative and non-immune compromised patients. We present a case of Kaposi's sarcoma of the face and scalp in a HIV-negative male with previous facial basal cell carcinoma....

  13. Introduktionslæger som vejledere - hvorfor?

    DEFF Research Database (Denmark)

    Skaarup, Anne Marie; Ringsted, Charlotte Vibeke

    2004-01-01

    Statusartiklen har til hensigt at beskrive det pædagogiske rationale for at anvende introduktionslæger som vejledere, holdningen blandt introduktionslæger og speciallæger til at bruge introduktionslæger som vejledere, og hvilke ulemper der kan identificeres, og hvordan de eventuelt kan overvindes...

  14. Tavs viden som led i vidensdiskursen

    DEFF Research Database (Denmark)

    Christensen, Jens

    2004-01-01

    Bidraget giver en  erkendelsesteoretisk tilgang til tavs viden som ressource i en teknologisk forandringsproces. Der tages udgangspunkt i, at tavs viden ikke kan betragtes uden at forholde sig til den mere generelle og historiske vidensdiskurs, som igen indgår i en kontekst af relationer mellem e...

  15. Sociale medier som læringsredskaber

    Directory of Open Access Journals (Sweden)

    Lill Ingstad

    2011-03-01

    Full Text Available Kan sociale medier anvendes som læringsredskaber til støtte for sociale, kollaborative processer, der er udfordrende og motiverende, og som samtidig understøtter (fremmedsprogstilegnelsen?Artiklen diskuterer eksempler på fagdidaktiske udfordringer i sprogundervisningen på CBS med fokus på engelsk.

  16. Contagem de células somáticas e produção de leite em vacas holandesas de alta produção Somatic cells count and milk yield in high production Holstein cows

    Directory of Open Access Journals (Sweden)

    Arlei Coldebella

    2003-12-01

    Full Text Available A mastite bovina pode ser clínica, com sinais visíveis, e subclínica, diagnosticada pela contagem das células somáticas. As perdas econômicas causadas pela mastite subclínica devem ser quantificadas para atender à demanda nacional de produtos lácteos. O objetivo deste trabalho foi verificar se as perdas na produção de leite, pelo aumento do número de células somáticas, são proporcionais ou independentes do nível de produção. Foram utilizadas 7.756 observações, colhidas mensalmente de um único rebanho, de setembro de 2000 a junho de 2002. A curva de lactação foi modelada pela função gama incompleta, e os efeitos de ordem de lactação, época do parto, ocorrência de doenças no periparto e escore de condição corporal ao parto também foram considerados. A contagem de células somáticas foi incluída nesse modelo como fator multiplicativo, representando perdas relativas, e como fator aditivo, representando perdas absolutas. A escolha do melhor modelo foi baseada no critério de informação de Schwarz (BIC. As perdas são absolutas, evidentes a partir de 14.270 células/mL e para cada aumento de uma unidade na escala do logaritmo natural a partir desse valor, estimam-se perdas de 184 e 869 g/dia para vacas primíparas e multíparas, respectivamente.The goal of this paper was to evaluate if losses in milk yield due to increase in somatic cells count are proportional or independent of the level of production. A total of 7,756 observations, monthly collected from a single herd from September/2000 up to June/2002, were used. The lactation curve was modeled by the incomplete gamma function, considering the effects of lactation order, calving season, peripartum disorder incidence and body condition score at calving. Somatic cells count was added to the model as a multiplicative factor, representing relative losses, and as an additive factor, representing absolute losses. The best model was chosen based on the information

  17. Embriogênese somática em híbridos de Pennisetum sp. e avaliação de estabilidade genômica por citometria Somatic embryogenesis in hybrids of Pennisetum sp. and genomic stability evaluation by cytometry

    Directory of Open Access Journals (Sweden)

    José Marcello Salabert de Campos

    2009-01-01

    Full Text Available Os objetivos deste trabalho foram estabelecer um protocolo eficiente de embriogênese somática, em híbridos triploides entre capim elefante (Pennisetum purpureum Schumach. e milheto (P. glaucum (L. R. Br., e avaliar por citometria de fluxo a estabilidade genômica das plantas obtidas in vitro. A embriogênese somática e a regeneração das plantas foram estabelecidas a partir de embriões zigóticos maduros de híbridos entre capim elefante e milheto. Foram testados quatro tratamentos com 2,4 ácido diclorofenoxiacético (2,4 D, nas concentrações 0, 1, 2 e 3 mg L-1, para indução de calos embriogênicos, e dois tratamentos com inositol a 1 e 2 g L-1, para regeneração das plantas. Os tratamentos foram dispostos em delineamento inteiramente ao acaso. A combinação ótima de hormônios foi de 2 mg L-1 de 2,4 D, para indução de calos embriogênicos, e de 1 g L-1 de inositol, para conversão de embriões e regeneração de plantas. A análise de quantidade de DNA, por citometria de fluxo das plantas regeneradas, indicou a não ocorrência de alterações em ploidia durante a embriogênese somática e a regeneração das plantas. A quantidade de DNA nuclear e a ploidia das plantas regeneradas foram estáveis e homogêneas em comparação às das plantas controle. Não ocorreu instabilidade cariotípica no sistema de regeneração usado para híbridos de Pennisetum.The objectives of this study were to establish an efficient protocol for somatic embryogenesis in triploid hybrids between napiergrass (Pennisetum purpureum Schumach. and pearl millet (P. glaucum (L. R. Br., and to assess the genomic stability by flow cytometry of the plants obtained in vitro. Somatic embryogenesis and plant regeneration were successfully established from mature zygotic embryos of napiergrass and pearl millet hybrids. Four treatments with 2,4 dichlorophenoxyacetic acid (2,4-D at 0, 1, 2 e 3 mg L-1 were tested for embryogenic calli induction and two treatments with

  18. Livsstil som tv-underholdning

    Directory of Open Access Journals (Sweden)

    Christa Lykke Christensen

    2008-09-01

    Full Text Available Livsstilsprogrammer har siden slutningen af 1990’erne domineret programfladen i den tidlige prime time på de danske public service-kanaler DR og TV 2. Dermed er emner, som figurerer i bl.a. magasiner og ugeblade, massivt rykket ind på tv’s sendeflade. Bolig, have, mad, ferie, krop og sundhed er indholdet i programmer, der både vil informere, give gode råd og underholde seerne. Artiklen fokuserer på underholdningsdimensionen i tre kategorier af livsstilsprogrammer og undersøger elementer, der kan tænkes at fremme motivationen for at se dem. Her lægges vægten på hhv. vidensperspektivets kompetenceaspekt og livsstilsbegrebets imaginative muligheder i relation til drømmen om ’det gode liv’ og ønsket om den forjættende forandring. Artiklen diskuterer endvidere, hvorledes public service-fjernsynet med disse livsstilsprogrammer har suppleret dets oplysende funktion med en opdaterende funktion, og hvordan dets tidligere kulturelt dannende funktion i kraft af disse programmers karakter af manual kan opfattes som en slags livsstilsguide i forhold til markedets forbrugsmuligheder. Lifestyle as TV entertainment Since the late 1990s lifestyle programmes have dominated early prime time on the Danish public service channels, DR and TV 2. For this reason topics that have traditionally figured in magazines extensively have entered television programming. House, garden, vacation, body, and health form the content of programmes which aim to both inform, advise and entertain viewers. The article primarily focuses on the aspects of entertainment in three main lifestyle categories and is concerned with elements that might promote viewers’ motivation for watching such programmes. Importance is attached to the competence aspect of knowledge and to the imaginative possibilities connected to the idea of lifestyle, related to daydreams, ideas of ‘the good life’, and a desire for promising change. Furthermore, the article discusses how public

  19. Livsstil som tv-underholdning

    Directory of Open Access Journals (Sweden)

    Christa Lykke Christensen

    2008-12-01

    Full Text Available Livsstilsprogrammer har siden slutningen af 1990’erne domineret programfladen i den tidlige prime time på de danske public service-kanaler DR og TV 2. Dermed er emner, som figurerer i bl.a. magasiner og ugeblade, massivt rykket ind på tv’s sendeflade. Bolig, have, mad, ferie, krop og sundhed er indholdet i programmer, der både vil informere, give gode råd og underholde seerne. Artiklen fokuserer på underholdningsdimensionen i tre kategorier af livsstilsprogrammer og undersøger elementer, der kan tænkes at fremme motivationen for at se dem. Her lægges vægten på hhv. vidensperspektivets kompetenceaspekt og livsstilsbegrebets imaginative muligheder i relation til drømmen om ’det gode liv’ og ønsket om den forjættende forandring. Artiklen diskuterer endvidere, hvorledes public service-fjernsynet med disse livsstilsprogrammer har suppleret dets oplysende funktion med en opdaterende funktion, og hvordan dets tidligere kulturelt dannende funktion i kraft af disse programmers karakter af manual kan opfattes som en slags livsstilsguide i forhold til markedets forbrugsmuligheder. Lifestyle as TV entertainment Since the late 1990s lifestyle programmes have dominated early prime time on the Danish public service channels, DR and TV 2. For this reason topics that have traditionally figured in magazines extensively have entered television programming. House, garden, vacation, body, and health form the content of programmes which aim to both inform, advise and entertain viewers. The article primarily focuses on the aspects of entertainment in three main lifestyle categories and is concerned with elements that might promote viewers’ motivation for watching such programmes. Importance is attached to the competence aspect of knowledge and to the imaginative possibilities connected to the idea of lifestyle, related to daydreams, ideas of ‘the good life’, and a desire for promising change. Furthermore, the article discusses how public

  20. Estudo de diferentes métodos de extração por Ultra-Som de pesticidas em latossolo utilizando técnicas cromatográficas

    OpenAIRE

    Marisa Maria Adams

    2002-01-01

    Amostras de solo (latossolo vermelho destroférrico) coletadas em três pontos distintos, no município de Caibaté (Região das Missões, RS), na profundidade de aproximadamente 10 cm (da superfície do solo), em diferentes estações do ano e com diferentes tipos de manejo de solo (plantio convencional; plantio direto e cultivo mínimo), foram analisadas com o intuito de verificar a presença e a persistência de pesticidas no solo. Adicionalmente foi avaliada a relação entre a concentração dos produto...

  1. Some Learning Properties of Modular Network SOMs

    Science.gov (United States)

    Takeda, Manabu; Ikeda, Kazushi; Furukawa, Tetsuo

    The Modular Network Self-Organizing Map (mnSOM) is a generalization of the SOM, where each node represents a parametric function such as a multi-layer perceptron or another SOM. Since given datasets are, in general, fewer than nodes, some nodes never win in competition and have to update their parameters from the winners in the neighborhood. This is a process that can be regarded as interpolation. This study derives the interpolation curve between winners in simple cases and discusses the distribution of winners based on the neighborhood function.

  2. "Hvem er som jeg blandt Guder?"

    DEFF Research Database (Denmark)

    Holst, Søren

    2004-01-01

    En hymne fra Dødehavsrullerne beskriver en persons opstigning til himlen, hvor den pågældende får tildelt overmenneskelig indsigt, som giver ham autoritet til at belære sine tilhængere på jorden. Hymnen analyseres, og der foretages en kritisk gennemgang af Israel Knohls bog "The Messiah Before Je...... Jesus", som hævder at teksten skulle handle om et medlem af Qumran-menigheden, som blev dræbt i Jerusalem og senere hævdedes at være opstået fra de døde....

  3. Videokameraet som etnografisk redskab online og offline

    DEFF Research Database (Denmark)

    Rehder, Mads Middelboe

    2013-01-01

    “Med udgangspunkt i et visuelt feltarbejde såvel online som offline, på YouTube og i New York City, beskæftiger dette kapitel sig med kameraet som medieringsteknologi, med fokus på levende billeder. Det diskuteres, hvordan kameraets multiple anvendelsesmuligheder empirisk og metodisk kan skabe...... forskellige muligheder og begrænsninger i et feltarbejde, samt hvordan det visuelle materiale kan variere som resultat af disse forskellige anvendelser. Den indledende del af kapitlet består af en beskrivelse af det empiriske felt online på YouTube, og det diskuteres, hvordan et online felt relaterer sig til...

  4. CEMSKUM - Anvendelighed som isoleringsmateriale i bygninger

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place

    2002-01-01

    Resume af rapport om mulighederne for at anvende Cemskum som isoleringsmateriale i bygningskonstruktioner, udarbejdet af Cemsystems I/S under Energistyrelsens udviklingsprogram "Miljø- og arbejdsmiljøvenlig isolering"...

  5. Estudo quantitativo das células de Langerhans em carcinomas basocelulares com maior e menor potencial de agressividade local Quantitative study of Langerhans cells in basal cell carcinoma with higher or lower potential of local aggressiveness

    Directory of Open Access Journals (Sweden)

    Itamar Santos

    2010-04-01

    Full Text Available FUNDAMENTOS - O carcinoma basocelular localiza-se principalmente em áreas expostas ao sol, apresentando formas clínicas e histológicas diferentes, algumas com grande e outras com pequena agressividade local. Células de Langerhans participam ativamente do sistema imune da pele. OBJETIVO - Avaliar quantitativamente as células de Langerhans sobrepostas aos carcinomas basocelulares de maior e menor potencial de agressividade local, assim como nas respectivas epidermes sãs adjacentes. MÉTODOS - Dois grupos com 14 preparações histológicas cada. No primeiro, carcinoma basocelular de menor potencial de agressividade local e, no segundo, carcinoma basocelular de maior potencial. Empregou-se a imunoistoquímica com proteína S100 para identificação das células de Langerhans. Utilizando microscópio óptico em aumento de 400 vezes e a grade morfométrica de Weibel, foram contadas as células de Langerhans presentes em sete campos, obtendo-se a média em cada lâmina. Foi utilizado teste estatístico de Wilcoxon para análise estatística. RESULTADOS - No grupo de menor potencial de agressividade local, na epiderme sã adjacente houve aumento significativo no número de células de Langerhans comparado ao da epiderme sobreposta ao carcinoma basocelular (p d 0,05. No grupo de maior potencial de agressividade local, não houve diferença com significado estatístico (p > 0,05. CONCLUSÃO - O maior número de células de Langerhans na epiderme sã vizinha à lesão tumoral de menor potencial de agressividade local poderia representar uma maior resistência imunológica da epiderme, limitando a agressividade da neoplasia.BACKGROUNDS - Basal cell carcinoma affects areas of the body that have been exposed to the sun, and this disorder has different clinical and histopathologic presentations. Some of these forms have a higher potential of local aggressiveness, while others have a lower potential. Langerhans cells actively participate in the skin

  6. Byen som bevægelsesgrund?

    DEFF Research Database (Denmark)

    Højbjerre Larsen, Signe

    2013-01-01

    Parkour er en bevægelseskultur der ikke udfolder sig i afgrænsede rum eller på bestemte tidspunkter. Den er i stedet betinget af at byens rum anvendes som bevægelsesgrund. Parkourudøvernes særegne brug af byrummet kalder på opmærksomhed og analytisk undren: Hvordan kan vi forstå et fænomen som pa...

  7. Idrætten som social generator

    DEFF Research Database (Denmark)

    Kural, René

    2002-01-01

    Med henvisning til to svømmehaller i hhv. Manchester og Berlin illustrerers det, hvorledes idrætten, store sportslige begivenheder og sportsfaciliteterne kan fungere som social generator for hele byafsnit.......Med henvisning til to svømmehaller i hhv. Manchester og Berlin illustrerers det, hvorledes idrætten, store sportslige begivenheder og sportsfaciliteterne kan fungere som social generator for hele byafsnit....

  8. Embriogénese somática em genótipos de Quercus suber análise bioquímica e histológica de produtos de reserva

    OpenAIRE

    Rodrigues, Sara Catarina Reis

    2014-01-01

    Dissertação de mestrado em Biotecnologia Vegetal, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra. Quercus suber (sobreiro) é uma planta com um grande interesse económico devido à produção de cortiça, sendo Portugal o principal produtor. A propagação tradicional da espécie por técnicas de multiplicação vegetativa permite assegurar a propagação clonal, mas apresenta fortes limitações, pelo que têm sido desenvolvidos ...

  9. Perdas na produção e qualidade do leite devido contagem de células somáticas no leite e estresse térmico de vacas da raça Holandesa em clima temperado

    Directory of Open Access Journals (Sweden)

    Agostinho Ludovico

    2015-10-01

    Full Text Available  O objetivo deste estudo foi avaliar a influencia da contagem de células somáticas (CCS no leite e o estresse térmico sobre a produção e composição do leite de vacas de um rebanho de produção comercial em região de clima temperado, durante o período de 2008 a 2012. Os dados do dia de controle leiteiro de 161±9 vacas Holandesas, totalizando 9650 ordenhas, foram fornecidos pela Associação Paranaense de Criadores de Bovinos da Raça Holandesa e analisados através de estatística descritiva, correlação, análise de variância e regressão. A produção média diária de leite foi de 31,78 kg/vaca, com diminuição de 29,31% quando o escore de contagem de células somáticas (ECS foi 9 e até 11% quando o Índice de Temperatura Equivalente (ITE foi 32 ou maior. Os teores de lactose decresceram a partir do ECS 0 até 9 e de gordura a partir de ECS 1 até 9, totalizando diminuição de 7,88 e 9,23%, respectivamente, quando o ECCS foi 9. Um efeito inverso foi observado em relação ao teor de proteína, o qual aumentou 3,6% com ECS 8, comparado com o ECS 0. A produção diária de sólidos totais iniciou perdas a partir do ECS 0 e totalizou perdas de 30,64% quando este foi 9. O aumento do ITE até 32 ou mais diminuiu a concentração de todos os componentes do leite, exceto de proteína, em valores de até 3,42% da concentração. Estes efeitos, somados a diminuição na produção diária de leite com este nível de ITE, totalizaram perdas de até 12,74% na produção de sólidos totais. Conclui-se que as perdas de produção e qualidade de leite com o aumento da CCS e ITE são significativas e podem justificar a adoção de medidas para prevenir infecções na glândula mamária e conforto de vacas leiteiras, mesmo em região de clima temperado.

  10. Avaliação estatística da variação da velocidade de propagação de ondas de ultra-som na madeira em presença de defeitos Statistical evaluation of the ultrasonic wave velocity variation in defective wood

    Directory of Open Access Journals (Sweden)

    Carlos T. Puccini

    2002-12-01

    Full Text Available Os métodos visuais para a detecção de defeitos na madeira, ainda que de grande utilidade, podem ser falhos e exigem a utilização de mão-de-obra relativamente bem treinada. Muitas vezes, a presença de nós, rachaduras ou, ainda, regiões com medula no interior de uma peça serrada, podem ser imperceptíveis na avaliação visual. Um dos grandes avanços obtidos nos últimos anos na caracterização de materiais, tanto do ponto de vista mecânico quanto da qualidade, é a aplicação de técnicas que utilizam a propagação de ondas, destacando-se, dentre elas, o ultra-som. O objetivo deste trabalho é avaliar, estatisticamente, a possibilidade de se utilizar o método do ultra-som na detecção de defeitos em peças de madeira serrada. Para isto, foram utilizadas 180 peças de dimensões nominais: 0,027 m de espessura; 0,10 m de largura e 0,25 m de comprimento, retiradas de vigas de Pinus sp obtidas em serraria da cidade de Campinas. As peças foram ensaiadas na umidade de equilíbrio ao ar. Para a realização dos ensaios utilizou-se o equipamento de emissão de ondas de ultra-som marca Steinkamp BP-7 com transdutores de 45 kHz. Inicialmente foi realizada uma análise visual das peças e, posteriormente, a determinação da velocidade de propagação das ondas nas mesmas peças. Com os resultados, realizou-se uma análise exploratória das variáveis e obteve-se um modelo de regressão logística visando verificar a relação entre a presença ou não de defeitos e a velocidade de propagação da onda do ultra-som na madeira. Os resultados demonstram uma forte relação entre a velocidade de propagação da onda de ultra-som e os defeitos detectados pela análise visualVisual methods to detect wood defects, although of great utility, can lead to inaccurate results and demand a specialist to carry it out. The presence of knots, cracks or pith regions inside a sawed piece can be imperceptible in the visual evaluation. One of the greatest

  11. Atividade basal de acetilcolinesterase e níveis plasmáticos de serotonina não se associam ao delirium em pacientes gravemente enfermos

    Directory of Open Access Journals (Sweden)

    Cristiane Damiani Tomasi

    2015-06-01

    Full Text Available RESUMO Objetivo: Investigar se os níveis plasmáticos de serotonina e atividade de acetilcolinesterase determinados por ocasião da admissão à unidade de terapia intensiva preveem a ocorrência de disfunção cerebral aguda em pacientes internados em unidade de terapia intensiva. Métodos: Foi conduzido no período entre maio de 2009 e setembro de 2010 um estudo prospectivo de coorte em uma amostra com 77 pacientes não consecutivos. A ocorrência de delirium foi determinada utilizando a ferramenta Confusion Assessment Method for the Intensive Care Unit, tendo sido determinadas as avaliações de acetilcolinesterase e serotonina em amostras de sangue coletadas até um máximo de 24 horas após admissão do paciente à unidade de terapia intensiva. Resultados: No presente estudo, 38 pacientes (49,6% desenvolveram delirium durante sua permanência na unidade de terapia intensiva. Nem os níveis de atividade de acetilcolinesterase nem os de serotonina tiveram associação independente com delirium. Não se observaram correlações significantes entre atividade de acetilcolinesterase e níveis de serotonina com o número de dias livres de delirium/coma, porém, em pacientes que desenvolveram delirium, ocorreu uma forte correlação negativa entre níveis de acetilcolinesterase e número de dias livres de delirium/coma, demonstrando que níveis mais elevados de acetilcolinesterase se associaram com menos dias de vida sem delirium e coma. Nenhuma associação foi identificada entre os biomarcadores e mortalidade. Conclusão: Nem a atividade de acetilcolinesterase nem os níveis séricos de serotonina se associaram com delirium ou disfunção cerebral aguda em pacientes gravemente enfermos. A ocorrência de sepse não modificou esse relacionamento.

  12. Crescimento somático do caranguejo-uçá Ucides cordatus (Crustacea, Brachyura, Ocypodidae em laboratório Somatic growth of the mangrove crab Ucides cordatus (Crustacea, Brachyura, Ocypodidae in laboratory

    Directory of Open Access Journals (Sweden)

    Giovana V. Lima

    Full Text Available Em crustáceos, o aumento de tamanho ocorre imediatamente após a muda, quando o animal está com a carapaça mole. O crescimento de Ucides cordatus (Linnaeus, 1763 foi observado em laboratório, através da ocorrência de muda, incremento de muda e período de intermuda. O estudo foi realizado durante os meses de outubro/2000 a março/2002 e um total de 91 caranguejos (15 machos, 33 fêmeas e 43 juvenis foi coletado no manguezal de Itacuruçá - Coroa Grande, Estado do Rio de Janeiro, Brasil. Os animais foram mantidos em dois tipos de tanques: os caranguejos adultos foram mantidos em tanques de 1000 l, durante 18 meses, enquanto os juvenis foram mantidos em tanques plásticos de 20 l de capacidade durante oito meses. Os animais foram mantidos em sistema aberto de circulação de água do mar e alimentados duas vezes por semana com folhas de Rhizophora mangle (L. (Rhizophoraceae e Laguncularia racemosa (Gaertn. (Combretaceae. A largura da carapaça variou entre 50,1 a 70,0 mm nos machos, 40,2 a 80,0 mm entre as fêmeas e 1,1 a 40,1 mm entre os juvenis. A sobrevivência dos espécimes estudados foi de 46,7% entre os machos, 39,4% entre as fêmeas após dezoito meses e 67,4% entre os juvenis, após oito meses de observação. Os machos e as fêmeas realizaram três mudas durante o experimento, enquanto os juvenis realizaram até duas mudas. As mudas ocorreram entre agosto e abril, mostrando maior freqüência durante a primavera e o verão. O incremento na largura da carapaça diminuiu com o tamanho do indivíduo, com média de 2,21 ± 1,39% para os machos, 1,28 ± 0,84% para as fêmeas e 2,89 ± 2,13% para os juvenis. A relação entre o incremento percentual e a largura da carapaça pode ser expresso pela equação IM = -0.0707LC + 4.645 (r²= 0.40. O período de intermuda foi de 191 ± 140 dias entre os machos, 216 ± 76,2 dias entre as fêmeas e 54 ± 1,41 dia entre os juvenis. O incremento de muda foi estatisticamente significativo (p

  13. Efeito do ultra-som terapêutico em tendinite experimental de eqüinos: estudo clínico, ultra-sonográfico e histopatológico de dois protocolos Clinic, ultrasonographic and histopatological studies of two protocols of ultrasonic therapy on experimental tendonitis in horses

    Directory of Open Access Journals (Sweden)

    M.A.L. Fernandes

    2003-02-01

    Full Text Available Avaliaram-se dois protocolos de ultra-som no tratamento de lesões do tendão flexor digital superficial (TFDS. Foram estudados 18 eqüinos, nos quais foi injetada uma solução de colagenase a 0,25% no TFDS esquerdo, à altura do terço médio da região metacarpiana. Os eqüinos foram divididos em: grupo A - tratado por ultra-som (UST na freqüência de 3 MHz e intensidade de 1W/cm², no modo contínuo, por seis minutos; grupo B - tratado na mesma freqüência, intensidade e tempo, no modo pulsado; e grupo C - controle. Os tratamentos foram iniciados 48h após a indução da lesão, totalizando oito sessões. Os eqüinos foram estudados por 40 dias, avaliando-se o quadro clínico e a regressão dos sintomas. Por meio de exames ultra-sonográficos semanais avaliaram-se a área transversal e a ecogenicidade da lesão para estabelecimento do índice de severidade (IS. A lesão resultou em aumento médio de 1,5cm na circunferência da região metacarpiana, resposta à pressão digital de leve a moderada e grau de claudicação de 1 a 3. A regressão dos sintomas ocorreu, em média, nove dias no grupo A, 12 dias no grupo B e 21 dias no grupo C. O percentual de regressão no IS aos 40 dias foi de 42,5, 57,7 e 34,1, respectivamente. A avaliação histológica mostrou neovascularização pronunciada e maior atividade fibroblástica nos grupos tratados (A e B comparados ao grupo-controle. Estes resultados sugerem que o UST é efetivo na redução dos sintomas clínicos da tendinite.In order to evaluate two therapeutic ultrasound protocols for treatment of injuries of the superficial digital flexor tendon (SDFT a study was performed in 18 horses. In each horse, a 0.25% solution of collagenase was injected in the middle of the left SDFT. The horses were randomly and equally divided into three groups. Horses from Group A were treated with therapeutic ultrasound of 3 MHz frequency and 1 W/cm² intensity on continuous mode for six minutes; horses from Group

  14. Kan Batman dateres? Om massekommunikasjonen som kulturhistorie

    Directory of Open Access Journals (Sweden)

    Hans Frederik Dahl

    1990-08-01

    Full Text Available Hans Frederik Dahls artikel er et bud på om massekommunikationen kan tænkes ind i kulturhistorien.Første halvdel af artiklen fremhæver de prob- lemer, det rejser, når massekommunikation med dens karakteristika i form af serialitet, triviatitet og internationalitet skal reflekteres i forhold til en kulturhistorisk tradition, som normalt tænker i begreber som tidsånd, kunstnerisk originalitet og nationalt særpræg. Sidste halvdel focuserer på tre centrale aspekter ved massekommunikationen, som også er af- gørende for dens kulturhistorie: dens nære forbindelse til musikken, dens internationale karakter og dens konstante tilbagevenden til tidligere pro- dukter.

  15. Kan Batman dateres? Om massekommunikasjonen som kulturhistorie

    Directory of Open Access Journals (Sweden)

    Hans Frederik Dahl

    1990-06-01

    Full Text Available Hans Frederik Dahls artikel er et bud på om massekommunikationen kan tænkes ind i kulturhistorien.Første halvdel af artiklen fremhæver de prob- lemer, det rejser, når massekommunikation med dens karakteristika i form af serialitet, triviatitet og internationalitet skal reflekteres i forhold til en kulturhistorisk tradition, som normalt tænker i begreber som tidsånd, kunstnerisk originalitet og nationalt særpræg. Sidste halvdel focuserer på tre centrale aspekter ved massekommunikationen, som også er af- gørende for dens kulturhistorie: dens nære forbindelse til musikken, dens internationale karakter og dens konstante tilbagevenden til tidligere pro- dukter.

  16. Kunst som metode i interaktiv forskning

    DEFF Research Database (Denmark)

    Jensen, Julie Borup

    for at påvirke feltet og skabe ny viden i interaktionsprocesser, bygger dette på en antagelse om, at interaktion mellem mennesker betjener sig af såkaldte medier for kommunikation og læring (Säljö 2003:196, Bruner 1996:76). I denne forståelse kan et medium eksempelvis være sproget, skriften, praksisrutiner, men...... et medium kan også være kunst og kunstværker. Kunstværker kan ses som et udtryk for en given kulturs antagelser om virkeligheden (Bruner 1996:), men også som en provokation eller udfordring til denne virkelighedsopfattelse (Darsø 2004). I forlængelse heraf kan kunst og kunstværker ses som...

  17. Om filmteori og filmhistorie: Stumfilmen som eksempel

    Directory of Open Access Journals (Sweden)

    Casper Tybjerg

    1995-09-01

    Full Text Available Tilbage til filmene og filmmagerne siger Casper Tybjerg i denne artikel. Han plæderer dog ikke nødvendigvis for en tilbagevending til "gammel- dags filmhistorieskrivning" og til en fokusering kun på film som æstetik og kunst. Med udgangspunkt i konkrete overvejelser over den danske stumfilm og gennemgang af væsentlige nyere filmhistoriske værker og teorier polemiserer han mod det han opfatter som upræcise og meget abstrakte kulturalistiske positioner, som enten glemmer de konkrete film eller overbetoner det blot formelle i filmhistorien. Samtidig tegner han også et levende billede af den kultur og de betingelser den tidlige film blev til i.

  18. Expressão de marcadores de proliferação celular e apoptose em carcinoma basocelular Markers expression of cell proliferation and apoptosis in basal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Marília de Pádua Dornelas Corrêa

    2009-12-01

    Full Text Available FUNDAMENTOS: O carcinoma basocelular é o câncer mais comum em humanos. Estudos que utilizam recursos da biologia molecular e genética, associados à histomorfologia, permitem a identificação de fatores de risco no desenvolvimento de lesões mais recorrentes e agressivas. OBJETIVO: Correlacionar a expressão dos marcadores de apoptose (p53 e Bcl-2 e proliferação celular (Ki-67 e PCNA com os indicadores histológicos de gravidade do tumor. MÉTODOS: Estudaram-se cinco amostras das formas nodular, morfeiforme e superficial, respectivamente, e um grupo-controle com três pacientes livres de lesão. Empregou-se o teste de Mann-Whitney na comparação da expressão desses marcadores com a forma de apresentação do carcinoma basocelular. RESULTADOS: Verificou-se que a marcação do Bcl-2 foi expressiva nos CBCs ditos agressivos (variantes morfeiforme e nodular. Dos tumores estudados, 66,7% (n = 10 indicaram fortemente o p53. Nossos resultados mostram maior expressão do Ki-67 no carcinoma basocelular nodular e superficial, sem expressão nos controles. O PCNA mostrou forte marcação em todos os tipos de tumores e nos controles. CONCLUSÃO: Os achados nos permitem concluir que o Bcl-2 e o p53 apresentam tendência para diagnosticar gravidade do carcinoma basocelular e o Ki-67, por seu comportamento variável, não pode ser considerado como marcador de gravidade, assim como o PCNA, que não foi um bom marcador de proliferação celular.BACKGROUND: - Basal cell carcinoma is the most common form of human cancer. Studies employing molecular and genetic biology techniques, associated with histomorphology, lead to the identification of risk factors in the development of more recurring and aggressive lesions. OBJECTIVE - To correlate markers expression of apoptosis (p53 and bcl-2 and cell proliferation (Ki-67 and PCNA with histological indicators of tumor severity. METHODS - Five samples of the nodular, morpheaform and superficial types of carcinoma

  19. Carcinoma basocelular - Análise de 300 casos observados em Uberlândia - MG Basal cell Carcinoma - Analysis of 300 cases observed in Uberlândia - MG, Brazil

    Directory of Open Access Journals (Sweden)

    Sônia Antunes Oliveira Mantese

    2006-03-01

    Full Text Available FUNDAMENTO: O carcinoma basocelular é o câncer da pele mais comum, compreendendo 75% dos tumores epiteliais malignos. Localiza-se na face e acomete indivíduos brancos, acima de 40 anos de idade, com história de exposição repetitiva à luz solar. OBJETIVO: Descrever o carcinoma basocelular em suas variáveis epidemiológica, clínica e histopatológica. CASUÍSTICA: Realizou-se estudo transversal de 300 pacientes com carcinoma basocelular atendidos no Serviço de Dermatologia do Hospital de Clínicas, no período de 1999 a 2003. Foram preenchidos protocolos com identificação do paciente, história de exposição solar e caracterização do carcinoma basocelular. RESULTADOS: Foram identificadas 447 lesões de carcinoma basocelular nos 300 pacientes estudados, cuja maioria era do sexo feminino (59,3% e da raça branca (93%, com história de exposição solar (90,3%, apresentando lesão única (74%, predominantemente facial (77% das lesões. O tipo histopatológico mais freqüente foi o nodular (46,3% das lesões, com predomínio do superficial no tronco. CONCLUSÕES: Observou-se predomínio do carcinoma basocelular no sexo feminino, demonstrando a tendência atual desse tumor. A presença de vários tumores sucessivos ou simultâneos em um mesmo paciente salienta a importância de exames periódicos nesses doentes. Não se estabeleceu correlação entre os tipos clínicos e histopatológicos. Confirmou-se que o tipo superficial é mais freqüente no tronco.BACKGROUND: Basal cell Carcinoma is the most common type of skin cancer and represents 75% of malignant epithelial tumors. It usually occurs on the face of white individuals aged over 40 years, with history of repetitive exposure to sunlight OBJECTIVE: To describe the epidemiological data, clinical presentation and histopathological findings of 300 patients with basal cell carcinoma. CASUISTIC: A cross-sectional study of 300 patients with Basal cell Carcinoma seen at the outpatient

  20. Musikterapi som samværsform

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner

    2005-01-01

    Det kan være svært for mennesker med omfattende demenssymptomer at deltage i aktiviteter eller samvær med andre – og uden interaktion med andre kan det være svært at få dækket psykosociale behov. Der er derfor brug for samvær og aktiviteter som er specielt tilrettelagt for at opfylde psykosociale...... erfaringer indenfor demensområdet. Der vil i foredraget blive taget udgangspunkt i praksiserfaring som musikterapeut på Plejehjemmet Caritas samt i et forskningsprojekt om individuel musikterapi, hvorfra der bliver vist videoeksempler....

  1. Skønlitteraturen som opposition

    DEFF Research Database (Denmark)

    Larsen, Pelle Oliver

    2011-01-01

    Troels Troels-Lund er kendt som foregangsmanden i den første kulturhistoriske bølge i Danmark fra omkring 1880. Hans form for kulturhistorie vandt imidlertid aldrig for alvor faghistorikernes anerkendelse, og Troels-Lund blev udgrænset. Denne artikel går tilbage til 1870’erne og indeholder en ana...

  2. Massemedier som forum for politisk debat

    DEFF Research Database (Denmark)

    Laursen, Bo; Trapp, Leila

    2015-01-01

    Ifølge normative teorier om politisk offentlighed og demokrati bør der i deliberative demokratier som det danske foregå en bred offentlig debat, inden politikere træffer beslutninger. Debatten, der i dagens Danmark hovedsagelig foregår i massemedierne, skal blandt andet sikre, at alle synspunkter...

  3. Brands som brikker i konstruktionen af identitet

    DEFF Research Database (Denmark)

    Hermansen, Judy

    2008-01-01

    Forbrug spiller en vigtig rolle i produktionen af mening og værdier, som kan skabe og vedligeholde både forbrugerens personlige og sociale verden - og derfor er reklame også en vigtig kilde til disse symbolske betydninger. Udgivelsesdato: juni...

  4. Perception som forståelsens grundlag

    DEFF Research Database (Denmark)

    Nielsen, Charlotte Marie Bisgaard

    2005-01-01

    sprogpsykologisk som sense-making procedurer. Perception har ifølge William James at gøre med personers forståelser. Monets katedralmalerier fra Rouen og Cézannes billeder fra Aix-en Provence samt hans Selvportræt med Bowlerhat (Ny Carlsberg Glyptotek) sammenholdes med Merleau-Pontys Perceptionens Primat og...

  5. Værdibasering som kommunal praksis

    DEFF Research Database (Denmark)

    Ostrowski, Kasper

    2009-01-01

    og tværkommunale forskelle foranlediget af kommunalreformen i Danmark. Begrebet ’værdibaseret ledelse’ gestaltes ofte med en både frustrerende lethed og på fascinerende vis som fænomen. Dette har ansporet min interesse for i denne afhandling at undersøge, hvorledes værdibaseret ledelse kan forstås...

  6. Selvrefleksion som uddannelsesgreb – en kritisk diskussion

    DEFF Research Database (Denmark)

    Feilberg, Casper

    2015-01-01

    Hvordan kan ureflekteret motivation gribe forstyrrende ind i de studerendes videnskabelige arbejde, og hvordan kan man som vejleder forholde sig til disse private forhold på en både faglig og etisk forsvarlig måde? I artiklen vises eksempler på, at studerende nemt kan komme til at agere ud fra ur...

  7. Supply Chain Management som interaktionel praksis

    DEFF Research Database (Denmark)

    Smith, Leo Feddersen; Lund, Anders

    2016-01-01

    I dette bidrag undersøger vi Supply Chain Management som en interaktionel praksis forankret i kommunikation. Med udgangspunkt i e-mail korrespondancer undersøger vi, hvordan køber-leverandør forholdet kommunikativt konstitueres mellem to danske SMVer og deres kinesiske leverandører. Det...

  8. Livsvalg konceptualiseret som dynamisk realisering af livsbaner

    DEFF Research Database (Denmark)

    Schnieber, Anette

    2009-01-01

    De valgsituationer, man i daglig tale kender som ”tilværelsens store valg”, mangler definition i den psykologiske litteratur, og det er således ikke klart, hvorvidt og evt. hvorledes disse valg adskiller sig fra andre typer. I artiklen gives en definition af ”de store valg”, og de adskilles fra...

  9. Feltarbejde som læringsrum

    DEFF Research Database (Denmark)

    Lund, Lisbeth Revsbæk

    2010-01-01

    artiklen beskrives, hvordan refleksionsrum og metakommunikative processer opleves af studerende, og hvilken betydning disse rum får for deres forståelse af såvel egne som uddannelsens læreprocesser. Artiklen er en del af en antologi, der tager sit udgangspunkt i de mange rum mellem uddannelse og profession......, databearbejdning, feltarbejde og teaching lab....

  10. Varehusbesøget som fornøjeligt hverdagsdrama

    DEFF Research Database (Denmark)

    Bouchet, Julie Kirstine Linderoth; Jantzen, Christian

    2014-01-01

    Artiklen analyserer de koreografiske, scenografiske og dramaturgiske virkemidler, som IKEA har anvendt til at skabe et succesfuldt oplevelsesdesign.......Artiklen analyserer de koreografiske, scenografiske og dramaturgiske virkemidler, som IKEA har anvendt til at skabe et succesfuldt oplevelsesdesign....

  11. "Tryllefløjten" som musik-historisk allegori

    DEFF Research Database (Denmark)

    Jensen, Jørgen I.

    1991-01-01

    Musikhistorie, Mozarts "Tryllefløjten", Mozart som historisk fænomen, oplysningstid, frimureri, musik og religion......Musikhistorie, Mozarts "Tryllefløjten", Mozart som historisk fænomen, oplysningstid, frimureri, musik og religion...

  12. Statistikeren skiftede spor som 49-årig

    DEFF Research Database (Denmark)

    Sølund, Sune; Rootzén, Helle

    2010-01-01

    En uddannelse til coach har ændret Helle Rototzens liv. Som 49-årig forlod hun et forskerliv på deltid til fordel for en karriere som DTU's eneste kvindelige institutdirektør.......En uddannelse til coach har ændret Helle Rototzens liv. Som 49-årig forlod hun et forskerliv på deltid til fordel for en karriere som DTU's eneste kvindelige institutdirektør....

  13. Adequação da contagem de células somáticas e da contagem bacteriana total em leite cru refrigerado aos parâmetros da legislação Suitability of somatic cell count and total bacterial count in raw refrigerated milk to legislation standards

    Directory of Open Access Journals (Sweden)

    G.A. Bozo

    2013-04-01

    Full Text Available O objetivo deste trabalho foi adequar a qualidade do leite cru refrigerado de cinco propriedades leiteiras aos parâmetros microbiológicos e de contagem de células somáticas (CCS estabelecidos pela legislação estadual do Paraná. As propriedades leiteiras estudadas foram monitoradas durante sete meses após a implantação de boas práticas de ordenha e de recomendações quanto ao tratamento de mastites e à manutenção e higienização de equipamentos de ordenha. Antes da adoção das recomendações, a contagem bacteriana total (CBT média era de 1,36 x 10(6UFC/mL e a CCS média, de 1,87 x 10(6/mL. Todas as propriedades atingiram os padrões estabelecidos para CBT, com redução média de 93,4%. A redução de CCS foi, em média, 74,3%. Apenas três propriedades atingiram os valores estabelecidos para CCS. As demais atingiram valores muito próximos ao limite. A adequação aos padrões de CBT e CCS gerou aumento na renda mensal, em razão do pagamento por qualidade do produto, entre R$120,00 e R$828,00, de acordo com a produção de cada propriedade.The aim of this work was to adequate raw refrigerated milk quality of five dairy farms to microbiological and somatic cell count (SCC standards established by Paraná state legislation. The dairy farms were monitored during seven months after the implementation of good milking practices and recommendations regarding mastitis treatment, and milking equipment maintenance and hygiene. Before the adoption of recommendations, the average total bacterial count (TBC was 1.36 x 10(6CFU/mL and average SCC was 1.87 x 10(6/mL. All farms reached established standards for TBC, originating an average reduction of 93.4%. Average SCC reduction was 74.3%. Only three farms reached established values for SCC. The remaining reached values near the limits. The suitability of TBC and SCC produced an increase in the monthly income due to payment quality reward of the dairy product, between R$120.00 and R$828

  14. Validação de equações de predição da taxa metabólica basal em sujeitos eutróficos e obesos

    Directory of Open Access Journals (Sweden)

    Renata Lopes Krüger

    2014-12-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2015v17n1p73   Equações de predição para taxa metabólica basal (TMB são amplamente utilizadas para prescrição dietética, porém podem apresentar valores diferentes daqueles medidos por calorimetria indireta (CI, principalmente, em indivíduos obesos. O objetivo deste estudo foi verificar os valores de TMB por meio da CI em indivíduos obesos de grau I e eutróficos e comparar com os resultados obtidos pelas equações de predição, a fim de identificar se existe discrepância nos valores obtidos entre o medido pela CI e o estimado pelas equações. O estudo avaliou 40 homens entre 18 e 30 anos, sendo 20 eutróficos e 20 obesos grau I. Foi verificado o grau de concordância entre as equações e CI por meio da metodologia sugerida por Bland e Altman (1986. Os resultados mostram a variação entre os métodos de predição de -19,6% a -9,1%, quando comparadas a CI nos sujeitos obesos, e de -4,2% a 4,4% nos eutróficos. Em ambos os grupos, a equação que mais se aproxima da estimativa real é a de Miflin St. Jeor (1990, com -9,1% de diferença da CI nos sujeitos obesos e 0,9% nos eutróficos. Desta forma, o presente estudo indica a utilização da equação de Mifflin St. Jeor (1990 para estimar a TMB. Entretanto, é fundamental que se consiga medir a TMB de sujeitos obesos de maneira mais precisa e segura, para melhor conduzir a intervenção baseada em exercícios físicos e boa alimentação.

  15. Poster som et pædagogisk redskab i sygeplejerskeuddannelsen

    DEFF Research Database (Denmark)

    Bagger, Bettan; Kelly, Hélène

    2008-01-01

    Som undervisere har vi gode erfaringer med, at de studerende anvender posters som redskab for formidling af viden. Posterne bruges som udgangspunkt for en mundtlig formidling af faglige perspektiver til de øvrige studerende. Formålet med at anvende formidling ved hjælp af en poster i...

  16. Efeito do ultra-som terapêutico contínuo em placas epifisárias de coelhos Efectos de la ultrasonografia terapéutica continua en placas epifisarias de conejos Effect of continuous therapeutic ultrasound in rabbit growth plates

    Directory of Open Access Journals (Sweden)

    Andersom Ricardo Fréz

    2006-06-01

    Full Text Available Devido aos efeitos terapêuticos, o ultra-som tem se tornado ferramenta indispensável no tratamento fisioterapêutico de alterações causadas por lesões e em diversas doenças, porém seu uso em pacientes pediátricos é controverso por possíveis distúrbios e danos à placa epifisária. O objetivo deste estudo é verificar se o ultra-som contínuo apresenta efeitos de alteração na placa de crescimento da tíbia de coelhas. Oito coelhas da raça Nova Zelândia com dois meses de idade foram submetidas a um tratamento usando ultra-som terapêutico de forma contínua com dose de 1W/cm² na região lateral da articulação do joelho direito por 5min, durante 10 dias com dois dias de intervalo após a 5ª aplicação. A articulação do joelho esquerdo foi utilizada como controle. A análise histológica mostrou uma alteração na espessura da cartilagem epifisária, sendo que no lado tratado o tamanho foi 24,40% maior do que no controle (p Debido a los efectos terapéuticos, la ultrasonografía se ha convertido en una herramienta indispensable al tratamiento fisioterapéutico de las alteraciones causadas por lesiones y en diversas enfermedades, a pesar de esto su uso en pacientes pediátricos es controversial por los posibles disturbios y daños a la placa epifisaria. El objetivo de este estudio es verificar si la ultrasonografía continua presenta efectos de alteración en la placa de crecimiento de al tibia de conejas. Ocho conejas de la raza Nueva Zelanda con 2 meses de edad fueron sometidas a un tratamiento usando ultrasonografía terapéutica de forma continua con dosis de 1W/cm² en la región lateral de la articulación de la rodilla derecha por 5 min, durante 10 días con 2 días de intervalo después de la 5ª aplicación. La articulación de la rodilla izquierda fue utilizada como control. El análisis histológico reportó una alteración en la espesura del cartílago epifisario, en el lado tratado el tamaño fue de 24,40% mayor del

  17. Nevoid basal cell carcinoma syndrome

    Science.gov (United States)

    NBCC syndrome; Gorlin-Goltz syndrome; Basal cell nevus syndrome; BCNS; Basal cell cancer - nevoid basal cell carcinoma syndrome ... Nevoid basal cell carcinoma nevus syndrome is a rare genetic ... syndrome is known as PTCH ("patched"). The gene is passed down ...

  18. Subsurface oxidation for micropatterning silicon (SOMS).

    Science.gov (United States)

    Zhang, Feng; Sautter, Ken; Davis, Robert C; Linford, Matthew R

    2009-02-03

    Here we present a straightforward patterning technique for silicon: subsurface oxidation for micropatterning silicon (SOMS). In this method, a stencil mask is placed above a silicon surface. Radio-frequency plasma oxidation of the substrate creates a pattern of thicker oxide in the exposed regions. Etching with HF or KOH produces very shallow or much higher aspect ratio features on silicon, respectively, where patterning is confirmed by atomic force microscopy, scanning electron microscopy, and optical microscopy. The oxidation process itself is studied under a variety of reaction conditions, including higher and lower oxygen pressures (2 and 0.5 Torr), a variety of powers (50-400 W), different times and as a function of reagent purity (99.5 or 99.994% oxygen). SOMS can be easily executed in any normal chemistry laboratory with a plasma generator. Because of its simplicity, it may have industrial viability.

  19. Basal cell carcinoma appearing in a facial nevus sebaceous of Jadassohn: dermoscopic features Carcinoma basocelular aparecendo em um nevo sebáceo de Jadassohn: características dermatoscópicas

    Directory of Open Access Journals (Sweden)

    Maria Leonor Enei

    2012-08-01

    Full Text Available The nevus sebaceous of Jadassohn usually affects the face or scalp. It tends to evolve in three stages, and the final stage is characterized by the appearance of tumours. We present the case of a facial nevus sebaceous of Jadasshon in which a basal cell carcinoma developed. We also explore the diagnosis of this disease, which was established through dermoscopy, and propose using this technique in the clinical follow-up of this type of hamartoma, thereby allowing the early detection of cancer development.O nevo sebáceo de Jadassohn geralmente afeta a face ou o couro cabeludo. A sua tendência natural é evoluir em três estágios, sendo que o estágio final é caracterizado pelo aparecimento de tumores. Apresentamos o caso de um nevo sebáceo de Jadassohn na face a partir do qual um carcinoma basocelular se desenvolveu. Também abordamos o diagnóstico dessa doença, estabelecido por meio da dermatoscopia. Sugerimos a utilização dessa técnica no acompanhamento clínico desse hamartoma, permitindo assim a detecção precoce de um câncer.

  20. Sæbeopera som Forestillingsgenererende Teknologi

    DEFF Research Database (Denmark)

    Waltorp, Karen

    2013-01-01

    Gennem en række empiriske eksempler fra Mauretanien, Danmark og Sydafrika analyserer artiklen dramaserier på tv som en art social teknologi, der tillader infor- manterne at generere forestillinger om andre liv og andre verdener, der på én gang er langt væk og tæt på. 'Soap operas' produceret i USA...

  1. Rousseau som modsvar til forceret talentudvikling

    DEFF Research Database (Denmark)

    Holm, Claus; Nielsen, Jens Christian

    2015-01-01

    pædagogisk syn på børn og unges udvikling. Men dette syn er nu under pres. Det kommer for eksempel til udtryk, når en international idrætsaktør som FC Barcelona vil oprette elitært orienterede fodboldakademier for børn ned til 6-årsalderen i Danmark. Men inspireret af filosoffen Jean-Jacques Rousseau og...

  2. Schelling og Nietzsche som kritikere af Descartes

    DEFF Research Database (Denmark)

    Liisberg, Sune

    2008-01-01

    : 'Hvad er det første for mig' - og svaret var: 'Det er jeg selv'. Cogito-argumentet, der implicerer en forudgående beslutning om at drage alt i tvivl, manifesterer således en historisk enestående 'frigørelse fra al autoritet' (Schelling). Ifølge Schelling - der ligesom Schopenhauer og Nietzsche havde...... blik for, at cogito-argumentet og dets problemer har med dets sprogbundethed at gøre - er ytringsdimensionen nu helt afgørende for cogito-argumentets meningsfuldhed, da allerede 'den blotte tanke 'Jeg er' kan forstås som en indre ytring og forudsætter et talende jeg'. Nietzsche henleder opmærksomheden...... på, at 'eftersom Descartes formulerer cogito-argumentet sprogligt, kan det ikke være nogen umiddelbar, første erkendelse'. Nietzsche antager nemlig, at Descartes selv fejlagtigt betragtede cogito-argumentet som en umiddelbar vished - altså strengt taget ikke som et argument. Men Descartes blev...

  3. Kierkegaard som eksistentiel fænomenolog

    DEFF Research Database (Denmark)

    Kierkegaard som eksistentiel fænomenolog er en antologi, som fremhæver de fænomenologiske aspekter i Kierkegaards beskrivelser af de grundlæggende fænomener i den menneskelige tilværelse. Den fokuserer på Kierkegaards anskuelse af mennesket som en konkret eksisterende person, et tænkende, følende...... og handlende subjekt, der altid har til opgave at forholde sig til sig selv, sin omverden og de andre. Bogen behandler for det første Kierkegaards eget fænomenologiske projekt og hans analyser af angst, fortvivlelse, blufærdighed, samvittighed, selvbedrag og autenticitet. For det andet hans forhold...... til samtidens eksistentielle tænkning (bl.a. Schelling og Poul Martin Møller) og ikke mindst hans forhold til eftertidens eksistentielle tænkning (bl.a. Jaspers, Wittgenstein, Agampen og Zisek). Og for det tredje Kierkegaards betydning for den senere eksistentielle psykologi og psykiatri....

  4. Det nordiske som brandværdi

    DEFF Research Database (Denmark)

    Hermansen, Judy

    2009-01-01

    Kommunikation spiller en vigtig rolle for, hvilke associationer forbrugeren har til brandet. Og da brand image består af summen af alle corporate aktiviteter, er der ifølge Roncha især én fællesnævner, som styrker strategierne bag nordisk brand management: Opbygningen af et globalt og konsistent...... brand under en nordisk designparaply, fordi design i mange år reelt har været en integreret del af det kulturelle og samfundsmæssige liv i Skandinavien. Men ikke alle nordiske designere, er tilfredse med de stilistiske associationer og begrænsninger, som er vokset op omkring det nordiske brand. Derfor...... er det også vigtigt at arbejde aktivt på at udvikle dets symbolske værdi. Der er ifølge Roncha en unik chance for at skabe et bæredygtigt brand, som ikke kun handler om bestemte stilarter eller kunstneriske værdier, men også om kvalitet og innovation. Udgivelsesdato: April...

  5. The pathogenesis of Fusarium oxysporum f. sp. narcissi and the role of antagonistic bulb-borne fungi in the chemical control of basal rot

    NARCIS (Netherlands)

    Langerak, C.J.

    1985-01-01

    The pathogenesis of <em>Fusarium> oxysporum f. sp. <em>narcissi

    Basal plates and roots of narcissus were infected by <em>Fusarium oxysporumem> Schlecht f. sp. <em>narcissi> (Cooke & Massee) Snyder &

  6. Sporløs – Om biologi, identitet og slægten som fjernsyn [Find My Family - On biology, identity and kinship on television] Sporløs – Om biologi, identitet og slægten som fjernsyn

    Directory of Open Access Journals (Sweden)

    Birgitta Frello

    2011-12-01

    Full Text Available During recent years, the Danish public service television station (DR has launched several documentary serials that focus on kinship and genealogy. Genealogy makes ‘good TV’ because it enables an immediate identification with the protagonist of the programme. Furthermore, the protagonist’s personal story can function as a vehicle for telling other stories. However, the way kinship is depicted in the serials presupposes that a person’s knowledge about her biological kin equals knowledge about her personal identity. The article analyses the serial <em>Find my Familyem> (Danish: <em>Sporløs>, discussing the naturalisation of biological kin and the possible consequences of the conceptualisation of kinship that is taken for granted in the serial.DR har i de senere år lanceret flere programserier, som har slægt og slægtsforskning som fokus. Slægtsprogrammer er ’godt fjernsyn’ i den forstand, at de giver mulighed for en umiddelbar identifikation med hovedpersonen, samtidig med at dennes historie kan bruges som løftestang for andre historier. Imidlertid anlægger programmerne en vinkel på slægten, som forudsætter, at et øget kendskab til den biologiske slægt automatisk medfører et øget kendskab til den personlige identitet. Denne selvfølgeliggørelse af den biologiske slægts betydning problematiseres i artiklen, og med udgangspunkt i Sporløs diskuteres mulige implikationer og konsekvenser af den forståelse af slægten, som programmerne tager udgangspunkt i og tager for givet.

  7. Arbejdspladsen som læringsmiljø

    DEFF Research Database (Denmark)

    Andersen, Vibeke; Hoyrup Pedersen, Steen

    Læring på arbejdspladsen er kommet i fokus både nationalt og internationalt som et stadigt vigtigere svar på videnssamfundets hurtigt eskalerende behov for kompetenceudvikling. Selvfølgelig kan arbejdspladslæring ikke erstatte de formaliserede erhvervs- og efteruddannelser, men arbejdspladsen er...... Workplace Learning. Konsortiet gennemfører i perioden 2001-2004 et større forskningsprogram, der udforsker læreprocesser i arbejdslivet og i samspillet mellem arbejdspladser og det formelle uddannelsessystem. Forskningsprogrammet er finansieret af Undervisningsministeriet og fokuserer primært på de...

  8. Minihusfellesskap som verkemiddel i stadsutvikling av Undredal

    OpenAIRE

    Underdal, Brita

    2017-01-01

    Små bygdesamfunn i Noreg slit med nedgang i folketalet, og det går ut over utvikling, handel og trivsel hjå dei som vert verande i bygda. I verste fall blir bygdene heilt fråflytta, husa forfell og naturressursane går til spille. Dette kan vere framtidsbiletet til Undredal om ikkje noko vert gjort. På 20 år har folketalet gått ned frå 130 innbyggjarar til 70. Dersom utviklinga ikkje stagnerer, vil bygda snart vere tom for fastbuande. Oppgåva stiller difor spørsmålet: Korleis kan ein auk...

  9. Epidemiology of basal cell carcinomas and squamous cell carcinomas in a Department of Dermatology: a 5 year review Epidemiologia dos carcinomas basocelulares e espinhocelulares em um Serviço de Dermatologia: revisão de 5 anos

    Directory of Open Access Journals (Sweden)

    Pedro Andrade

    2012-04-01

    Full Text Available BACKGROUND: Non-melanoma skin cancer, a common designation for both basal cell carcinomas and squamous cell carcinomas, is the most frequent malignant skin neoplasm. OBJECTIVE: Epidemiologic characterization of the population with Non-melanoma skin cancer. METHODS: Retrospective analysis of all patients diagnosed with Non-melanoma skin cancer based on histopathologic analysis of all incisional or excisional skin biopsies performed between 2004 and 2008 in a Department of Dermatology. RESULTS: A total of 3075 Non-melanoma skin cancers were identified, representing 88% of all malignant skin neoplasms (n=3493 diagnosed in the same period. Of those, 68,3% were basal cell carcinomas. Most Non-melanoma skin cancer patients were female and over 60 years old. Of all Non-melanoma skin cancer, 81,7% (n=1443 were located in sun-exposed skin, and represented 95,1% of malignant skin neoplasms in sun-exposed skin. Non-melanoma skin cancer was the most frequent malignant skin neoplasm in most topographic locations, except for abdomen and pelvis - over 95% of all malignant skin neoplasms in the face, neck and scalp were Non-melanoma skin cancer. Basal cell carcinomas were clearly predominant in all locations, except in upper and lower limbs, lower lip and genitals, where squamous cell carcinomas represented respectively 77,7%, 77,4%, 94,7% and 95,3% of the Non-melanoma skin cancers. CONCLUSION: Being the most common skin cancer, Non-melanoma skin cancer should be under constant surveillance, in order to monitor its epidemiologic dynamics, the efficiency of preventive measures and the adaptation of the healthcare resources.FUNDAMENTOS: O cancro cutâneo não-melanoma, designação conjunta para os carcinomas basocelulares e espinhocelulares, é o tipo de neoplasia cutânea maligna mais frequente. OBJETIVOS: Caracterização epidemiológica da população diagnosticada com cancro cutâneo não-melanoma. MÉTODOS: Foi realizada uma análise retrospectiva dos

  10. How the type of pyrogenic organic matter determines the SOM quality in amended soils

    Science.gov (United States)

    Merino, Agustin; Gartzia-Bengoetxea, Nahia; Morangues, Lur; Arias-Gonzalez, Ander

    2016-04-01

    Charred biomass can be used as an organic amendment and to enhance the C sink capacity of soils. There are two types of by-products containing pyrogenic OM that could be used to improve in agricultural or forestry, biochar and wood ash. Due to their different heating conditions under which it is produced (pyrolysis, combustion and different temperatures, feedstocks,..), the properties of this pyrogenic OM might be highly variable, which could affect the SOM quality and the C sink capacity of the amended soil. The purpose of this study was to assess how SOM quality is influenced by pyrogenic organic matter with different degree of carbonization. Biochar and bottom wood ash were added to two Atlantic forest soils (Pinus radiata, 12 °C, 1200 mm) with different texture, clayey loam and sandy loam. The experiment consisted in a randomized block trials, in which different doses of biochar (0, 3, 9, 18 Mh ha-1) and wood ash (0, 1.5, 4.5, and 9 Mg ha-1) were added. The Biochar applied (pH: 9.8; C: 87 %) was produced by the pyrolysis of Myscanthus sp. at 450°C in a Pyreg® pyrolysis unit. The bottom wood ash (pH: 10.6; C: 30 %) was produced by combustion in a biomass power plant. The aromatization/carbonization was lightly higher in biochar than in wood ash. This latter by-product, in addition to the black carbon, it also contained mineral ash, as well as unburnt or lightly charred plant biomass. The evolution of soil chemical and SOM properties were monitored over three years by solid state Differential Scanning Calorimetry (DSC) and 13C CPMAS NMR. These techniques were applied in bulk samples and also in fractions of different densityes. The changes in microbial activity were studied by analysis of microbial biomass C and basal respiration and soil microbial community. Three years after applications the SOM content increased lightly in the treatment receiving the highest doses of biochar and wood ash, specially in the clay loam soil. SOM in the treated soils displayed a

  11. IKT som empowerment af lærer og elever!

    DEFF Research Database (Denmark)

    Christiansen, René B.; Binggeli, Andreas

    2011-01-01

    I denne korte artikel ønsker vi at pege på at ikt kan fungere som empowerment for både lærere og elever i skolen. It optræder i forvejen i alt for mange menneskers bevidsthed som en barriere eller som en sten i den pædagogiske sundhedssandal. Vi har begge på egen krop oplevet at arbejdet med ny t...

  12. Indicadores do ambiente ruminal e suas relações com a composição do leite e células somáticas em diferentes períodos da primeira fase da lactação em vacas de alta produção Indicators of rumen environment and their relation with milk composition and somatic cells in the first phase of lactation in high-yielding dairy cows

    Directory of Open Access Journals (Sweden)

    Rómulo Campos

    2006-04-01

    Full Text Available No atual sistema internacional de pagamento do leite por qualidade, têm-se valorizado dois aspectos fundamentais: a contagem de células somáticas (CCS e o conteúdo de sólidos totais. O primeiro fator depende da saúde da glândula mamária e o segundo, de maior importância econômica para os laticínios, está relacionado com o manejo alimentar e a raça dos animais. O ambiente ruminal pode modificar a composição do leite, em especial o teor de gordura. A fonte principal de proteína nos ruminantes depende da síntese de proteína no rúmen. Os atuais sistemas de alimentação, usados em vacas de alta produção, predispõem os animais à apresentação de síndromes metabólicas o que direta ou indiretamente afeta a produção de leite. Objetivou-se, com o presente trabalho, relacionar indicadores do ambiente ruminal (tempo de redução com azul de metileno e pH e o pH da urina com a composição do leite (sólidos totais e a CCS. Não foi encontrada associação estatística entre os parâmetros avaliados. Os valores médios dos sólidos não-gordurosos analisados no estudo foram inferiores ao limite estabelecido pela norma oficial do Brasil.In the current international milk payment system, where the quality is the main factor; two fundamental aspects have acquired great importance: the somatic cells count and the amount of total solids. The first one depends on the health of the mammary gland and the second factor, which has more economic impact for the dairy industry, is directly related to feeding management and the cattle breed. The environment of the rumen can modify the composition of the milk, specially the fat percentage. The main source of protein in the ruminants depends on the synthesis of protein in the rumen. The current feeding systems used in high-yielding dairy cows, predispose them to the outcome of metabolic syndromes that directly or indirectly affect the milk production. The purpose of this study was to establish a

  13. Estudo da eficiência das ondas de ultra-som em relação ao hipoclorito de sódio e à filtração adsorção na eliminação de microrganismos em estação de tratamento de água

    OpenAIRE

    Bello, Antonio Roberto Crystal [UNESP

    2003-01-01

    Este estudo realizado em mini Estação de Tratamento de Água (ETA-CB) relata a comparação entre diferentes processos como ondas ultra-sônicas, cloração e filtração-adsorção na eliminação de microrganismos e adequação de outros parâmetros exigidos para água de abastecimento público. Para avaliar a influência de cada processo de desinfecção e também dos processos de coagulação - floculação, decantação e filtração foi projetada e construída uma ETA em escala piloto, constituída de caixa de entrad...

  14. Med øjeblikket som udgangspunkt

    DEFF Research Database (Denmark)

    Bo, Inger Glavind

    Artiklen er motiveret af, at Meads temporale analyser tilsyneladende ikke har fået den plads og opmærksomhed, de fortjener, og formålet er at argumentere for, at disse er afgørende for forståelsen af helt centrale aspekter i hans tænkning. Meads udgangspunkt for sin analyse af temporalitet er en...... perspektiv på identitet og social interaktion i hans socialpsykologi. Denne artikels formål er således dobbelt og er for det første at præsentere og diskutere Meads temporale perspektiv som en relevant indgang og nøgle til hans socialpsykologi og sideløbende hermed for det andet at argumentere for, at de...... temporale analyser er centrale for at få greb om Meads genialitet....

  15. Empowerment som frigørelse?

    DEFF Research Database (Denmark)

    Andersen, Pernille Tanggaard

    2010-01-01

    Empowerment er et at tidens modeord, og sættes i forbindelse med vidt forskellige termer eksempelvis personlighedsudvikling, borgerinddragelse og styringsideologi. Begrebet empowerment rummer efterhånden så mange betydninger, at man kan diskuterer selve essensen – i dette kapitel gøres dog et...... forsøg og forskellige dele af begrebet udfoldes. Direkte oversat betyder empowermemt at bemyndige eller sætter i stand til. Empowerment er et ofte anvendt begreb indenfor sundhedsvidenskab og i tilrettelæggelse af sundhedsfremmende initiativer. Begrebet bliver ofte defineret og benyttet forskelligt alt...... efter det bagvedliggende ideologiske perspektiv, og derfor er udgangspunktet i dette kapitel også at illustrerer forskellige ”blikke på empowerment”. Derudover inddrages to eksempler; studier af lokalsamfund og borgerinddragelse og ’den motiverende samtale’ som illustration på, hvilke udfordringer, der...

  16. Børnetegninger som orienteringsspor og forskningsdata

    DEFF Research Database (Denmark)

    Nielsen, Anne Maj

    2012-01-01

    orientation and to discuss how children’s art and drawings can be approached as research data. The construct of children’s art and drawings are comprised of a double approach: Children’s drawings are conceptualized as articulations of not yet thematized emotions, experiences and meaningfulness...... hvordan de er blevet anvendt i forskning samt diskuterer forskellige perspektiver på tegninger som forskningsmateriale og anvendelse af tegninger i forskning. The article aims to illustrate how children’s art and drawings can produce knowledge of children’s personal, experience-based and gendered...... and the articulations include use and learning of visual socio-cultural codes and symbols. The construct comprise an existential-phenomenological and a socio-cultural learning oriented approach. A variation of examples is presented to illustrate the use of children’s drawings in research and to discuss the introduced...

  17. Fænomenologisk dekonstruktion som udspørgning

    DEFF Research Database (Denmark)

    Keller, Kurt Dauer

    Merleau-Ponty skelner udspørgning (interrogation) fra de dominerende opfattelser af refleksion, dialektik og intuition. Udspørgning må betragtes som hans bud på den begrebs- og traditionskritik, Heidegger kaldte ”destruktion”, og som Derrida førte videre under den mere adækvate betegnelse...

  18. Music playlist generation by assimilating GMMs into SOMs

    NARCIS (Netherlands)

    Balkema, Wietse; van der Heijden, Ferdinand

    A method for music playlist generation, using assimilated Gaussian mixture models (GMMs) in self organizing maps (SOMs) is presented. Traditionally, the neurons in a SOM are represented by vectors, but in this paper we propose to use GMMs instead. To this end, we introduce a method to adapt a GMM

  19. Tv-fiktion som tværmedial oplevelsesdesign

    DEFF Research Database (Denmark)

    Sandvik, Kjetil

    2010-01-01

    konstrueres og et bestemt handlingsforløb simuleres, fra de mere kulørte og parapsykologisk funderede fremgangmetoder i serier som The Profiler og Medium, til mere realistiske praksiser som i Rejseholdet og CSI. Og jeg vil endvidere lave en sammenlignende analyse med virkelighedens gerningsstedsefterforskning...

  20. Tema 1: Robotdidaktik. Læringsrobotter som indhold i undervisningen.

    Directory of Open Access Journals (Sweden)

    Jens Jørgen Hansen

    2016-01-01

    Full Text Available Robotter er en teknologi som i disse år bevæger sig ind i skolen. Spørgsmålet er med hvilken didaktisk begrundelse og dermed læringsmæssig relevans man kan arbejde med robotter i skolen? Hvorfor skal eleverne beskæftige sig med robotter? Dette spørgsmål er en opgave for didaktikken at svare på, hvilket sætter robotdidaktik på didaktikkens landkort. I artiklen undersøges en række didaktiske designs fra projektet Fremtek,hvor lærere bl.a. har eksperimenteret med at udvikle undervisningsforløb med humanidrobotter – en slags læringsrobotter -­‐ som omdrejningspunkt (Majgaard 2014. Robotters funktion som indhold i disse didaktiske design analyseres ud fra Frede V. Nielsens fire indholdskategorier: indhold som fænomen, som realia og kontekst, som aktivitet og metode og som personligog social erfaringsfelt. Målet er at udvikle en kritisk og kreativ refleksion over og diskussion af robotteknologi som mål og middel i skolen og andre uddannelsesinstitutioner og bidrage til udvikling af en robotdidaktik, der kan støtte og vejlede undervisere i at foretage didaktiske valg og kvalificere eksperimenter med robotter i undervisningen.

  1. Tema 1: Robotdidaktik. Læringsrobotter som indhold i undervisningen.

    Directory of Open Access Journals (Sweden)

    Jens Jørgen Hansen

    2015-12-01

    Full Text Available Robotter er en teknologi som i disse år bevæger sig ind i skolen. Spørgsmålet er med hvilken didaktisk begrundelse og dermed læringsmæssig relevans man kan arbejde med robotter i skolen? Hvorfor skal eleverne beskæftige sig med robotter? Dette spørgsmål er en opgave for didaktikken at svare på, hvilket sætter robotdidaktik på didaktikkens landkort. I artiklen undersøges en række didaktiske designs fra projektet Fremtek,hvor lærere bl.a. har eksperimenteret med at udvikle undervisningsforløb med humanidrobotter – en slags læringsrobotter -­‐ som omdrejningspunkt (Majgaard 2014. Robotters funktion som indhold i disse didaktiske design analyseres ud fra Frede V. Nielsens fire indholdskategorier: indhold som fænomen, som realia og kontekst, som aktivitet og metode og som personligog social erfaringsfelt. Målet er at udvikle en kritisk og kreativ refleksion over og diskussion af robotteknologi som mål og middel i skolen og andre uddannelsesinstitutioner og bidrage til udvikling af en robotdidaktik, der kan støtte og vejlede undervisere i at foretage didaktiske valg og kvalificere eksperimenter med robotter i undervisningen.

  2. Long-term effects of cholinergic basal forebrain lesions on neuropeptide Y and somatostatin immunoreactivity in rat neocortex

    NARCIS (Netherlands)

    Gaykema, R.P.A.; Compaan, J.C.; Nyakas, C.; Horvath, E.; Luiten, P.G.M.

    1989-01-01

    The effect of cholinergic basal forebrain lesions on immunoreactivity to somatostatin (SOM-i) and neuropeptide-Y (NPY-i) was investigated in the rat parietal cortex, 16-18 months after multiple bilateral ibotenic acid injections in the nucleus basalis complex. As a result of the lesion, the

  3. Evaluation of Strontium Selectivity by Sandia Octahedral Molecular Sieves (SOMS).

    Energy Technology Data Exchange (ETDEWEB)

    Rigali, Mark J.; Stewart, Thomas Austin

    2016-01-01

    Sandia National Laboratories has collaborated with Pleasanton Ridge Research Company (PRRC) to determine whether Sandia Octahedral Molecular Sieves (SOMS) and modified SOMs materials can be synthesized in large batches and produced in granular form. Sandia National Laboratories tested these SOMS and its variants based in aqueous chemical environments for an application-based evaluation of material performance as a sorbent. Testing focused primarily on determining the distribution coefficients (K d ) and chemical selectivity SOMs for alkali earth (Sr) ions in aqueous and dilute seawater solutions. In general the well-crystallized SOMS materials tested exhibited very high K d values (>10 6 ) in distilled water but K d values dropped substantially (%7E10 2 -10 3 ) in the dilute seawater (3%). However, one set of SOMS samples (1.4.2 and 1.4.6) provided by PRRC yielded relatively high K d (approaching 10 4 ) in dilute seawater. Further examination of these samples by scanning electron microscopy (SEM) revealed the presence of at least two phases at least one of which may be accounting for the improved K d values in dilute seawater. Evaluation of Strontium Selectivity by Sandia Octahedral Molecular Sieves (SOMS) January 20, 2016

  4. Udvidelsen af relationsfeltets didaktik – med religionsundervisningen som eksempel

    DEFF Research Database (Denmark)

    Skovmand, Keld

    beskrive denne dobbeltbevægelse som en almen fagdidaktik (Nielsen 1998 [1994]) eller – med inspiration fra Klafki – en relationsfeltets didaktik (Nielsen 2012). Dobbeltblikket på didaktikken som et relationsfelt kan kvalificeres ved hjælp af de fire kriterier for indholdsvalg, som er udformet af Frede V...... specificere indhold (DuFour & Marzano 2011). Referencer DuFour, Richard & Marzano, Robert J. 2011: Leaders of learning. How district, school, and classroom leaders improve student achievement. Bloomington, IN: Solution Tree Press. Hattie, John 2009: Visible learning. A synthesis of over 800 meta...

  5. Tv-serien som vor tids roman?

    DEFF Research Database (Denmark)

    Nielsen, Jakob Isak

    2012-01-01

    Artiklen gør rede for de forbindelseslinjer, der er mellem den nyere amerikanske tv-serie og en række andre udtryksformer (fx radiospillet og spillefilmen) for dernæst at fokusere på tv-seriens slægtskab med romanen. Alene i Danmark har såvel kulturjournalister som forskere påpeget ligheder de...... to udtryksformer imellem, og artiklen vil forsøge at skabe et overblik over berøringsfladerne og parallellerne. Artiklens tese er, at sammenligningen er gangbar i forhold til en række parametre – særligt hvis man indsnævrer de i udgangspunktet temmelig heterogene og vidtfavnende udtryksformer ”romanen” og ”tv......-serien” og fokuserer på bestemte eksempler og strømninger samt på bestemte distributions-, brugs- og oplevelsesformer (særligt DVD-udgivelsen ifm. tv-serier fx). Eksemplerne er primært fra en række nyere amerikanske tv-serier fra The Sopranos (HBO, 1999-2007) og frem, og artiklen vil afslutningsvist påpege...

  6. Giant basal cell carcinoma Carcinoma basocelular gigante

    Directory of Open Access Journals (Sweden)

    Nilton Nasser

    2012-06-01

    Full Text Available The basal cell carcinoma is the most common skin cancer but the giant vegetating basal cell carcinoma reaches less than 0.5 % of all basal cell carcinoma types. The Giant BCC, defined as a lesion with more than 5 cm at its largest diameter, is a rare form of BCC and commonly occurs on the trunk. This patient, male, 42 years old presents a Giant Basal Cell Carcinoma which reaches 180 cm2 on the right shoulder and was negligent in looking for treatment. Surgical treatment was performed and no signs of dissemination or local recurrence have been detected after follow up of five years.O carcinoma basocelular é o tipo mais comum de câncer de pele, mas o carcinoma basocelular gigante vegetante não atinge 0,5% de todos os tipos de carcinomas basocelulares. O Carcinoma Basocelular Gigante, definido como lesão maior que 5 cm no maior diâmetro, é uma forma rara de carcinoma basocelular e comumente ocorre no tronco. Este paciente apresenta um Carcinoma Basocelular Gigante com 180cm² no ombro direito e foi negligente em procurar tratamento. Foi realizado tratamento cirúrgico e nenhum sinal de disseminação ou recorrência local foi detectada após 5 anos.

  7. Time travel in the homogeneous Som-Raychaudhuri Universe

    International Nuclear Information System (INIS)

    Paiva, F.M.; Reboucas, M.J.; Teixeira, A.F.F.

    1987-01-01

    Properties of the rotating Som-Raychaudhuri homogeneous space-time are investigated: time-like and null geodesics, causality features, horizons and invariant characterization. An integral representation of its five isometries is also discussed. (author) [pt

  8. Portræt af litteraturkritikeren som ungt menneske

    DEFF Research Database (Denmark)

    Schatz-Jakobsen, Claus

    2004-01-01

    Artiklen præsenterer den amerikanske litteraturkritiker Geoffrey Hartmans tidlige forfatterskab og fremdrager dets selvbiografiske undertekst som nødvendig effekt af den unge Hartmans fascination af den engelske romantiker William Wordsworths forfatterskab.......Artiklen præsenterer den amerikanske litteraturkritiker Geoffrey Hartmans tidlige forfatterskab og fremdrager dets selvbiografiske undertekst som nødvendig effekt af den unge Hartmans fascination af den engelske romantiker William Wordsworths forfatterskab....

  9. Ole Rømer som enevældens administrator

    DEFF Research Database (Denmark)

    Olden-Jørgensen, Sebastian

    2002-01-01

    En gennemgang af Ole Rømers liv med vægt på hans rolle som embedsmand og hans deltagelse eller mangel på samme i det politiske spil.......En gennemgang af Ole Rømers liv med vægt på hans rolle som embedsmand og hans deltagelse eller mangel på samme i det politiske spil....

  10. Identification of illicit drugs by using SOM neural networks

    Energy Technology Data Exchange (ETDEWEB)

    Liang Meiyan; Shen Jingling; Wang Guangqin [Beijing Key Lab for Terahertz Spectroscopy and Imaging, Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Department of Physics, Capital Normal University, Beijing 100037 (China)], E-mail: liangyan661982@163.com, E-mail: jinglingshen@gmail.com, E-mail: pywgq2004@163.com

    2008-07-07

    Absorption spectra of six illicit drugs were measured by using the terahertz time-domain spectroscopy technique in the range 0.2-2.6 THz and then clustered with self-organization feature map (SOM) artificial neural network. After the network training process, the spectra collected at another time were identified successfully by the well-trained SOM network. An effective distance was introduced as a quantitative criterion to decide which cluster the new spectra were affiliated with.

  11. Brands som ideologiske parasitter

    DEFF Research Database (Denmark)

    Hermansen, Judy

    2009-01-01

    De store, stærke brands, som rager op over alle andre som repræsentanter for nogle værdier, der bliver lagt vægt på i samfundet, kalder Douglas Holt for ikoniske. Vi snakker Coca Cola, Nike, Apple ligaen. For at opnå en sådan status er brandingen nødt til at holde et vågent øje med tendenser og...

  12. Identification of illicit drugs by using SOM neural networks

    International Nuclear Information System (INIS)

    Liang Meiyan; Shen Jingling; Wang Guangqin

    2008-01-01

    Absorption spectra of six illicit drugs were measured by using the terahertz time-domain spectroscopy technique in the range 0.2-2.6 THz and then clustered with self-organization feature map (SOM) artificial neural network. After the network training process, the spectra collected at another time were identified successfully by the well-trained SOM network. An effective distance was introduced as a quantitative criterion to decide which cluster the new spectra were affiliated with

  13. Future of newer basal insulin

    OpenAIRE

    Madhu, S. V.; Velmurugan, M.

    2013-01-01

    Basal insulin have been developed over the years. In recent times newer analogues have been added to the armanentarium for diabetes therapy. This review specifically reviews the current status of different basal insulins

  14. Por que a percussão de uma mola produz o mesmo som de “pistolas laser” do filme Star Wars?

    Directory of Open Access Journals (Sweden)

    Jair Lúcio Prados Ribeiro

    2014-03-01

    Full Text Available http://dx.doi.org/10.5007/2175-7941.2014v31n2p385 Ao se bater lateralmente em uma mola metálica esticada, é produzido  um sibilo,  um  efeito  sonoro  que  se  tornou parte da cultura atual devido à sua popularização como o som de uma “pistola laser” no filme Star Wars. O sibilo ocorre devido à dispersão do som em um metal, mas a revisão de obras didáticas de ensino médio e superior mostra que a discussão desse fenômeno não está presente. Apresentamos uma atividade experimental possível de ser conduzida no ensino médio, a fim de detectar o sibilo e analisá-lo em um programa de edição de som. A análise gráfica permitiu determinar, de forma aproximada, que há uma relação inversamente proporcional entre a frequência do som que se propaga na mola e o tempo de detecção.

  15. Fællesskab som fællesgørende bevægelse?

    DEFF Research Database (Denmark)

    Khawaja, Iram

    2014-01-01

    man kan tale om, og som noget, der konstant forhandles. 3. Fællesskab som situeret og forbundet med subjektivering 4. Fællesskab som hverken overindividuel eller subjektiv bevægelse og 5. Fællesskab som forbundet med belonging. Artiklen bevæger sig imellem teoretisk og empirisk analyse og inddrager et...... fokus på belonging som en central dimension i forståelsen af konstruktionen af fællesskaber....

  16. Programproduktion som Kritisk Teori – eller tv-teksten som industriel iscenesættelse

    Directory of Open Access Journals (Sweden)

    John Caldwell

    2003-09-01

    Full Text Available Denne artikel peger på nødvendigheden af en revurdering af den tre-delte model, som Fiske og Gripsrud har fremført, ved at vise, hvorledes ‘sekundære’ og ‘tertiære’ tv-tekster uafladeligt bevæger sig eller rejser hen imod en ‘primær’ tekstuel status i det amerikan- ske multikanals-»flow«. En detaljeret gennemgang af industriens tekstuelle praksis – programbegivenheder, network-branding, ka- nallogoer, filmene bag filmen, pressemateriale på video, salgsma- teriale og tilgrænsende digitale medier – viser hvorledes industrien teoretiserer sine egne vilkår direkte på skærmen, og dermed også hvordan publikum vejledes igennem en sådan offentlig cirkulation af »inside«-viden om tv-systemet. Artiklen er oversat af Henrik Bødker.

  17. Esplenectomia subtotal para tratamento do hipodesenvolvimento somático e sexual secundário a esplenomegalia

    Directory of Open Access Journals (Sweden)

    Andy Petroianu

    Full Text Available OBJETIVO: "Nanismo esplênico" é condição clínica decorrente de processo imunitário relacionado ao baço e tem como tratamento preconizado a esplenectomia total. Seguindo uma linha de pesquisa voltada ao estudo da esplenectomia subtotal em diferentes afecções, o objetivo do presente trabalho foi avaliar o crescimento somático de pacientes portadores deste hipodesenvolvimento esplenomegálico, submetidos à esplenectomia subtotal com preservação do pólo superior esplênico irrigado apenas pelos vasos esplenogástricos. MÉTODO: Quatro pacientes masculinos (14, 14, 16 e 17 anos com esplenomegalia (três de etiologia esquistossomática e um com cirrose auto-imune e retardo do desenvolvimento somático e sexual foram submetidos à esplenectomia subtotal. As indicações para cirurgia foram sangramento de varizes do esôfago e pancitopenia. RESULTADOS: Em todos os casos houve retomada do crescimento e após um ano eles já se encontravam dentro da faixa de desenvolvimento somático e sexual compatível com a idade. CONCLUSÃO: O hipodesenvolvimento esplenomegálico não é decorrente da presença do baço, mas de seu crescimento; a esplenectomia subtotal é um procedimento adequado para tratar o retardo de desenvolvimento somático e sexual por esplenomegalia.

  18. Mindfulness som smertehåndteringsredskab for kvinder med endometriose

    DEFF Research Database (Denmark)

    Jensen, Mette Kold; Vedsted-Hansen, Hanne; Hansen, Tia G. B.

    2011-01-01

    Endometriose er en kronisk underlivssygdom med smerter og en række afledte problemer, som ikke nødvendigvis kan behandles med lægelige tiltag. Artiklen argumenterer for, at en mindfulness-baseret tilgang med fokus på smertehåndtering kan anvendes til denne klientgruppe. I vestlig terapeutisk...... sammenhæng kan mindfulness karakteriseres som nærvær, observation og beskrivelse af sansninger uden vurdering eller reaktion. Mindfulness-træning har effekt mod andre typer stress og kroniske smerter, og artiklen opridser et koncept til anvendelse ved endometriose. Konceptet belyses med en case, hvor...

  19. Ole Rømer som enevældens administrator

    DEFF Research Database (Denmark)

    Olden-Jørgensen, Sebastian

    2004-01-01

    En biografisk skitse af Ole Rømers virke med vægt på hans rolle som embedsmand og rådgiver for Christian V. Hans virke analyseres på baggrund af en ny forståelse for den tidlige enevældes politiske kultur.......En biografisk skitse af Ole Rømers virke med vægt på hans rolle som embedsmand og rådgiver for Christian V. Hans virke analyseres på baggrund af en ny forståelse for den tidlige enevældes politiske kultur....

  20. Kongehuset som varemærke og nationalt symbol

    DEFF Research Database (Denmark)

    Ravn Sørensen, Anders

    2016-01-01

    Kongehuset er ikke bare et nationalt symbol. Det er også et varemærke, som der er al mulig grund til at beskytte og vogte nidkært over. Kronen har nemlig god brandmæssig værdi.......Kongehuset er ikke bare et nationalt symbol. Det er også et varemærke, som der er al mulig grund til at beskytte og vogte nidkært over. Kronen har nemlig god brandmæssig værdi....

  1. Avaliação dos níveis basais de FSH em pacientes inférteis com endometriose profunda de ovário tratadas cirurgicamente Evaluation of basal FSH serum levels in infertile patients with deep ovarian endometriosis who underwent surgery

    Directory of Open Access Journals (Sweden)

    Sandra Frankfurt

    2009-07-01

    Full Text Available OBJETIVO: avaliar a reserva ovariana de pacientes inférteis portadoras de endometriose profunda de ovário, submetidas à cirurgia excisional dos endometriomas, atendidas entre os meses de Fevereiro e Novembro de 2008. MÉTODOS: estudo prospectivo que incluiu 30 pacientes portadoras de endometriose graus III e IV com comprometimento profundo de ovário submetidas à cirurgia excisional dos endometriomas e 30 pacientes portadoras de endometriose graus I e II que foram alocadas como Grupo Controle. A reserva ovariana foi avaliada indiretamente a partir do valor do hormônio folículo estimulante (FSH basal (U/L, entre o terceiro e quinto dias do ciclo, após um período de 12 meses da cirurgia. O índice de massa corpórea (IMC foi calculado conforme a fórmula de Quetelet [peso (kg/estatura (cm²]. Para a comparação das variáveis "idade", "IMC" e "valores de FSH basal" entre os grupos, foi utilizado o teste não paramétrico U de Mann-Whitney. RESULTADOS: não foi encontrada diferença significativa entre os grupos em relação à idade e ao IMC. Em relação ao FSH basal, observou-se que, no grupo das pacientes com endometriose profunda, o valor médio foi de 7,0 U/L, enquanto que, no Grupo Controle, foi de 5,6 U/L (p=0,3, o que demonstra que a diferença no valor médio de FSH encontrado nos dois grupos não foi significativa. CONCLUSÕES: a cirurgia não influenciou de forma deletéria a reserva ovariana das pacientes com endometriose profunda de ovário.PURPOSE: to evaluate the ovarian reserve of infertile patients with severe ovarian endrometriosis, submitted to excisional surgery of endometriomas and attended from February to November, 2008. METHODS: prospective study, including 30 patients with endometriosis grades III and IV, with severe ovarian impairment, submitted to excisional surgery of the endometriomas, and 30 patients with endometriosis grades I and II, allocated as a Control Group. The ovarian reserve was indirectly assessed

  2. Report Card on Basal Readers.

    Science.gov (United States)

    Goodman, Kenneth S.; And Others

    This report examines the nature of the modern basal reader, its economics, and use. First, the report provides a history showing how the confluence of business principles, positivistic science, and behavioral psychology led to the transformation of reading textbooks into basal readers. Next, the report examines objectives and subjective factors…

  3. Digital portfolio som metode og pædagogik

    DEFF Research Database (Denmark)

    Toft, Hanne; Luplau Schnefeld, Mette

    2004-01-01

    Artiklen præsenterer erfaringer med digital portfolio som didaktik og metode. Fokus er på kobling mellem didaktiske læreprocesser på en grunduddannelse og så understøttelse af disse via brug af en digital portfolio. Portfolioen adskiller en række forskellige dokumentsamlinger i privat og offentlig...

  4. Rushdie som symbol på blasfemi mod islam

    DEFF Research Database (Denmark)

    Jacobsen, Brian Arly

    2012-01-01

    Vil man forstå dødsdommen over Rushdie, skal man forstå billederne om Iran, der er konstrueret af Rushdie i De Sataniske Vers. Det handler om Rushdies brug af forskellige narrativer, eksempelvis brugen af begrebet 'Jahilia', som er velkendt af alle muslimer, der anvendes til at karakterisere Mekk...

  5. Sansning som redskab og metode for faget Modedesign

    DEFF Research Database (Denmark)

    Ræbild, Ulla

    2009-01-01

      Abstract / dansk Intentionen i denne afhandling er at undersøge, hvornår og hvordan designere anvender sansemæssig viden og kompetence i deres arbejdsproces, for igennem denne afdækning at kunne foretage en eksplicitering og artikulation af sansning som redskab og metode i designprocessen. Afha...

  6. Læring som improviseret udvikling af praksis

    DEFF Research Database (Denmark)

    Brinck, Lars

    2010-01-01

    Med afsæt i forfatterens fænomenografiske studie af amerikanske musikeres oplevelse af det at jamme diskuterer artiklen, hvorvidt jam-bandets spontant improviserende praksis kan give ny forståelse af rytmiske musikeres læring som et overordnet socialt fænomen. Ved at betragte jam-bandets praksis i...

  7. Feedback i professionsuddannelsen som pædagog

    DEFF Research Database (Denmark)

    Rold, Mette; Bjørnshave, Inge Andrea

    2015-01-01

    Feedback som begreb er her og nu kommet i søgelyset på de videregående uddannelser, fordi mange studerende, blandt andet i medierne, tilkendegiver at de ikke modtager nok feedback i forhold til den undervisning, de modtager. Dette paper er udgangspunkt for en fælles diskussion om netop dette....

  8. Content Management som platform og pædagogisk strategi

    DEFF Research Database (Denmark)

    Petersen, Kim Bach; Rasmussen, Steen Cnops

    2005-01-01

    Med afsæt i konkrete erfaringer på pædagoguddannelsen argumenteres der for, at implementeringen af it-systemer og udviklingen af de ansattes it-kompetencer bør tage afsæt i en pædagogisk tænkning, som prioriterer enkelthed og brugervenlighed højt....

  9. Socialpædagogik iagttaget som et socialt praksisfelt

    DEFF Research Database (Denmark)

    Hansen, Janne Hedegaard

    2013-01-01

    Ved at iagttage socialpædagogers situerede handlinger i praksis er det muligt at opnå viden om de forståelser, socialpædagoger handler på grundlag af, og som sætter betingelser for brugernes handle- og livsmuligheder. Men brugerne er ikke blot underlagt socialpædagogers betydningskonstruktioner...

  10. Pave Benedikt XVI som social kritiker og moderniseringsteoretiker

    DEFF Research Database (Denmark)

    Thomassen, Bjørn

    2013-01-01

    former for kritik af det moderne projekt, en kritik som deler mange lighedspunkter med Frankfurterskolen. Disse ligheder kom blandt andet til syne i Kardinal Ratzingers berømte debat med Habermas, men ligeledes i nogle af hans seneste skrifter, især hans meget omtalte tredje encyklik, Caritas in Veritate...

  11. Corporate film som værktøj til employer branding

    DEFF Research Database (Denmark)

    Hansen, Heidi

    2016-01-01

    En corporate film kan ses som organisationens autoritative tekst kommunikeret i en enkelt digital fortælling. I denne artikel belyses corporate film som genre fra henholdsvis kommunikationsdirektørens, forskerens, det kreative bureau og filmskaberens side.......En corporate film kan ses som organisationens autoritative tekst kommunikeret i en enkelt digital fortælling. I denne artikel belyses corporate film som genre fra henholdsvis kommunikationsdirektørens, forskerens, det kreative bureau og filmskaberens side....

  12. Inducción de embriogénesis somática en Alstroemeria spp.

    Directory of Open Access Journals (Sweden)

    Cruz Ivan Guillermo

    2003-12-01

    Full Text Available

    Esta investigación se llevó a cabo con el objetivo de inducir la embriogénesis somática en el genotipo de <em>Alstroemeria AAZ59 em>como alternativa ante las dificultades que presenta su propagación y por su importancia como flor de corte. A tal fin, se evaluó el tipo de explante con mayor potencial embriogénico y su interacción con reguladores de crecimiento, la consistencia del medio de cultivo y el fotoperiodo. Así mismo, se probaron cinco reguladores de crecimiento: 2,4-D, tidiazuron (TDZ, picloran, bencilaminopurina (BAP y ácido indolbutírico (AIB, en tres combinaciones y diferentes concentraciones; también se evaluaron medios de cultivo sólidos con adición de 5,7 g/l de agar y medios líquidos. Se estudiaron diferentes tipos de explantes: tres tipos de hojas en diferentes estados de desarrollo y segmentos de pedicelo provenientes de plantas establecidas en campo, además de segmentos de brotes sacados de plántulas <em>in vitroem>. Todos los tratamientos fueron evaluados bajo dos condiciones de fotoperiodo: la primera condición con 16 horas luz (5.000 lux y ocho horas de oscuridad, y la segunda condición en oscuridad total. Se logró la embriogénesis somática directa a partir de segmentos de pedicelo y de segmentos de brotes <em>«Halvdød av frost, men levende og beredt». Speiderbevegelsen som disiplineringsprosjekt

    OpenAIRE

    Schaanning, Espen

    2013-01-01

    I det som gjerne betegnes som speidernes Bibel, Scouting for Boys (1908), løftet speiderbevegelsens grunnlegger, Robert Baden-Powell (1857–1941), fram personer som alle speidergutter burde ha som forbilder. Et slikt forbilde beskrives slik: «Den romerske soldaten fra gamle dager, som ble stående på sin post da Pompeii ble begravd av lava og aske fra vulkanen Vesuv, viste lojalitet mot sin plikt. De har funnet liket hans og kan se hvordan han holdt hånden foran munn og nese for ikke å bli kval...

  13. Soil organic matter (SOM) dynamics determined by stable isotope techniques

    International Nuclear Information System (INIS)

    Gerzabek, M. H.

    1998-09-01

    Being aware of limitations and possible bias the 13 C natural abundance technique using the different 13 C enrichments in plants with differing photosynthetic pathways in a powerful tool to quantify turnover processes, both in long-term field studies and short-term laboratory experiments. Special care is needed in choosing reference plots and the proper number of replicate samples. The combination of 13 C and 14 C measurements has a high potential for a further improvement of isotope techniques in SOM studies. Natural abundance of 15 N is less powerful with respect to quantification of SOM processes than the isotope dilution technique. However its usefulness could be distinctly improved by introducing other stable isotopes into the studies.(author)

  14. Terapias somáticas para transtornos psiquiátricos resistentes ao tratamento Somatic therapies for treatment-resistant psychiatric disorders

    OpenAIRE

    Raphael J Braga; Georgios Petrides

    2007-01-01

    OBJETIVO: O presente artigo é uma revisão do conhecimento atual relativo às terapias somáticas em psiquiatria, com foco em transtornos psiquiátricos resistentes ao tratamento usual. MÉTODO: Foi realizada uma pesquisa computadorizada da literatura no Medline utilizando as palavras "eletroconvulsoterapia", "estimulação magnética transcraniana", "terapia magnética convulsiva", "estimulação do nervo vago" e "estimulação cerebral profunda", com todos os termos traduzidos para o idioma inglês. Refe...

  15. Musik som værk og handling

    DEFF Research Database (Denmark)

    Vandsø, Anette

    Denne bog handler om den nye musik som både har værkkarakter men også en udpræget handlingskarakter. Her sys på symaskiner og smadres violiner, men hvad gør det ved værkkarakteren? ved værkanalysen ? og ved 'musikken'? På baggrund af disse spørgsmål tilbyder bogen en grundlagsteoretisk gentænkning...

  16. Den Pædagogiske Refleksionsmodel som sammenhængskraft

    DEFF Research Database (Denmark)

    Voergaard Poulsen, Bettina; Lucht, Camill; Vibholm Persson, Stine

    Den Pædagogiske Refleksions Model (PRM) illustrerer de vidensdimensioner, der indgår i en kvalificeret klinisk beslutning. I projektet 'Sammenhæng på TVÆRS i fremtidens sygeplejeuddannelse (PÅ TVÆRS)" indgår PRM som pædagogisk greb. Der undersøges om PRM skaber sammenhæng for studerendes læring i...

  17. Som Energia: sostenibilitat energètica i cooperativisme

    OpenAIRE

    Duran i Grant, Alexandre; Huijink, Gijsbert; Roselló, Marc

    2013-01-01

    La cooperativa Som Energia és una organització innovadora en el sector energètic a casa nostra. Proposa una forma de fer diferent de la de les empreses tradicionals del sector: ven energia renovable certificada, no té ànim de lucre i busca el bé comú. La proposta treballa per la sostenibilitat energètica.

  18. Studiemiljøundersøgelse som empowerment

    DEFF Research Database (Denmark)

    Keller, Hanne Dauer; Jensen, Annie Aarup

    2012-01-01

    Artiklen fokuserer på det metodemæssige i at arbejde med studiemiljø og studiemiljøundersøgelser i en kvalitativ, procesorienteret form, der står i kontrast til de traditionelle kvantitative metoder. En alternativ organisering med de studerende som ansvarlige aktører gav andre, mere nuancerede da...... datatyper og aktiverede de studerende i forhold til at påvirke eget studiemiljø....

  19. Sociale teknologier og web 2.0 som vidensmedier

    DEFF Research Database (Denmark)

    Johannsen, Carl Gustav

    2011-01-01

    Artiklen fokuserer på effekten af brugen af sociale teknologier i folkebibliotekerne med fokus på i hvilken udstrækning de sociale teknologier lader sig forstå og analysere som vidensmedier, kommunikationsmønstre ved brug af sociale medier, de sociale mediers virkninger i undervisningssammenhænge...... og endelig de kulturpolitiske konsekvenser af bibliotekernes inddragelse af sociale teknologier....

  1. Specialestuderendes læringsudfordringer i vejledningen - nudging som handlemulighed

    DEFF Research Database (Denmark)

    Jensen, Hanne Nexø; Juul Jensen, Christina

    2015-01-01

    teoretiske afsæt er generiske læringsudfordringer i vejledningsprocesser, hvor læring opstår, når de studerende passerer en læringsudfordring. Vejledere kan bruge forståelsen af læringsudfordringer til at ”nudge”- plante en idé – som en måde at få studerende til at passere læringsudfordringerne....

  2. Feedback som indgang til læringsprocessen

    DEFF Research Database (Denmark)

    Kirkegaard, Preben Olund

    2017-01-01

    Feedback har til formål at forbedre dine studerendes færdigheder i et fag. Feedback skal tage udgangspunkt i den studerendes nuværende færdigheder og inkludere anvisninger på, hvordan den studerende fremadrettet kan arbejde for at opfylde et ønsket læringsmål. Måden hvorpå du som underviser...

  3. Betyder modellering det samme i naturfag som i matematik?

    DEFF Research Database (Denmark)

    Ejersbo, Lisser Rye

    2014-01-01

    Med de nye målformuleringer og læseplaner bruges udtrykket modellering nu både indenfor naturfag og matematik. Matematiklærere, som er vant til at arbejde med modellering tror måske, at det betyder det samme begge steder, men det behøver slet ikke at være tilfældet. Måske vi trænger til en...

  4. Technology Marketing using PCA , SOM, and STP Strategy Modeling

    OpenAIRE

    Sunghae Jun

    2011-01-01

    Technology marketing is a total processing about identifying and meeting the technological needs of human society. Most technology results exist in intellectual properties like patents. In our research, we consider patent document as a technology. So patent data are analyzed by Principal Component Analysis (PCA) and Self Organizing Map (SOM) for STP(Segmentation, Targeting, and Positioning) strategy modeling. STP is a popular approach for developing marketing strategies. We use STP strategy m...

  5. Prevalência de lesões cutâneas actínicas em pacientes com carcinoma basocelular do segmento cefálico: um estudo caso-controle Prevalence of actinic skin lesions in patients with basal cell carcinoma of the head: a case-control study

    Directory of Open Access Journals (Sweden)

    Valquíria Pessoa Chinem

    2012-04-01

    Full Text Available OBJETIVO: Avaliar a preval��ncia de lesões cutâneas actínicas em portadores de carcinoma basocelular do segmento cefálico. MÉTODOS: Foi conduzido estudo tipo caso-controle. Os casos, constituídos por pacientes com carcinoma basocelular sólido, primário, menor que dois centímetros, no segmento cefálico; e controles, por pacientes com outras dermatoses. Foram analisadas variáveis constitucionais, comportamentais e lesões actínicas. RESULTADOS: Avaliaram-se 120 casos e 360 controles. Mílio facial (OR = 2,3, leucodermia puntacta de membros superiores (OR = 2,9 e cutis romboidalis nuchae (OR = 1,8 associaram-se à neoplasia independentemente das demais variáveis, sugerindo um fenótipo de risco. Houve ainda associação com fenótipos claros, genética familiar e exposição solar cumulativa. Queimadura solar, tabagismo e alcoolismo não foram identificados como fatores de risco. O uso de fotoprotetores não evidenciou proteção; porém, o grupo controle era composto por pacientes dermatológicos, aos quais são indicados fotoprotetores regularmente. CONCLUSÃO: Lesões actínicas foram mais prevalentes em portadores de carcinoma basocelular sólido do segmento cefálico que em controles, especialmente mílio, cutis romboidalis nuchae e leucodermia puntacta, independentemente dos demais fatores de risco conhecidos.OBJECTIVE: To evaluate the prevalence of actinic skin lesions in patients with basal cell carcinoma of the head. METHODS: A case-control study was carried out. Cases were patients with primary, solid basal cell carcinoma of the head, less than two centimeters in diameter; and as controls, patients with other dermatoses. Constitutional and behavioral variables were analyzed, as well as actinic lesions. RESULTS: One hundred twenty cases and 360 controls were evaluated. Facial milia (OR = 2.3, leukoderma punctata of the upper limbs (OR = 2.9, and cutis rhomboidalis nuchae (OR = 1.8 were associated with neoplasms regardless

  6. O Estudo de Colisões através do Som

    Directory of Open Access Journals (Sweden)

    Cavalcante Marisa Almeida

    2002-01-01

    Full Text Available O experimento proposto neste artigo permite ao professor de Física estabelecer uma metodologia computacional para o estudo de movimentos e, particularmente, do coeficiente de restituição em colisões através do espectro sonoro emitido por impactos sucessivos de uma esfera em uma superfície plana. O método de medida sugerido, além de requerer um equipamento de fácil acesso, propicia adequada precisão, como revelam os dados obtidos, já que a aquisição é realizada através de placas de som de microcomputadores pessoais, com tempos de resolução, hoje, da ordem de 23 mis para taxas de amostragem de até 44 Khz. Utilizamos um software de análise do espectro sonoro que apresenta o sinal na forma de gráfico de freqüência versus tempo, livremente disponível na Internet e com uma ampla disponibilidade de recursos.

  7. Ação do paradiclorobenzeno sôbre os cromossômios somáticos

    Directory of Open Access Journals (Sweden)

    Cândida H. T. Mendes Conagin

    1950-01-01

    Full Text Available Neste trabalho são apresentados os resultados obtidos com Coffea arabica, Allium cepa, Arachis prostrata e Aloë sp., pela aplicação do processo Meyer para o estudo dos cromossômios somáticos. Em linhas gerais, o processo consta das seguintes fases : a tratamento de raízes por uma solução saturada de paradiclorobenzeno ; b fixação em Carnoy ; c hidrólise em HCl a 10%, a 60°C durante dois minutos ; d lavagens em água destilada ; e lavagens em ácido acético a 45% ; f coloração dos esfregaços pela orceína acética. Em virtude dêsse tratamento, os cromossômios se contraem e se apresentam bem separados nas placas metafásicas, sendo facilitada a sua determinação numérica. As constrições, a duplicidade e os satélites nos cromossômios, ficam também postos em evidência. Trata-se de um processo que pode substituir, com a vantagem da rapidez, o processo lento, de exame dos cromossômios somáticos por meio de cortes de material incluído em parafina, nas espécies estudadas.The effects of a prefixation treatment with paradichlorobenzene on the somatic chromosomes of Coffea arabica, Allium cepa, Arachis prostrata and Aloë sp. have been studied. The following schedule was followed for treating root tips : a prefixation in a solution of paradichlorobenzene ; b fixation in Carnoy ; c hydrolisis in 10 per cent HCI for two minutes at 60°C ; d washing in distilled water ; e washing in 45 per cent acetic acid ; f smearing and staining in aceto-orcein. Good smears were obtained with root tips of Coffea arabica, Allium cepa and Aloe sp. The chromosomes of Coffea arabica were well scattered in the cells. The long chromosomes of Allium cepa and Aloe sp. were also well separated from each other. No difference in the chromosomes was noticed in smears made from paradichlorobenzene treated and untreated root tips of Arachis prostrata. This technique can substitute the paraffin method to advantage for counting chromosome number in root tip

  8. Improving productivity and quality in plastic and thin metallic plates manufacturing by using ultrasonic welding processes Melhorando a produtividade e qualidade na fabricação em plástica e chapas finas de metal por soldagem por ultra-som

    Directory of Open Access Journals (Sweden)

    D. Dehelean

    2009-12-01

    Full Text Available The paper presents an overview of the research done at the Romanian National R&D Institute for Welding and Material Testing ISIM Timisoara in the field of ultrasonic process development. It starts with a general presentation of the value added by the welding sector in Europe. There are presented figures representing the size of the welding sector in Romania. The need of development of new high efficiency welding processes is mentioned, ultrasonic welding being one of the special welding processes with exceptional application perspectives. Practical examples of industrial application of the ultrasonic welding process for joining plastic and metallic materials are presented. A special case study refers to the welding of new shape memory alloys. The use of the ultrasonic welding instead of an conventional welding process has lead in each presented case study to an increase of the efficiency of the welding process through higher productivity and saving of manpower, consumable, energy.Este trabalho apresenta um panorama dos trabalhos de pesquisa conduzidos no Instituto nacional Romeno de P&D em Soldagem e Avaliação de Materiais (ISIM - Timisoara no desenvolvimento de processos ultrassônicos. Ele se inicia com uma apresentação geral pelo valor adicionado pelo setor de soldagem à Europa. São apresentados valores representativos do tamanho do setor de soldagem na Romênia. A necessidade do desenvolvimento de novos processos de soldagem de alta eficiência é mencionada, sendo a soldagem ultrassônica um dos processos especiais de soldagem com perspectivas excepcionais de aplicação. Exemplos práticos da aplicação industrial deste processo de soldagem para a união de plásticos e de metais são apresentados e um caso especial se refere à soldagem de novas ligas com efeito de memória de forma. O uso de soldagem por ultrassom no lugar de um processo convencional de soldagem resultou, em cada um dos estudos de caso apresentados, em um aumento

  9. Nevoid basal cell carcinoma syndrome

    Directory of Open Access Journals (Sweden)

    Kannan Karthiga

    2006-01-01

    Full Text Available Binkley and Johnson first reported this syndrome in 1951. But it was in 1960, Gorlin-Goltz established the association of basal cell epithelioma, jaw cyst and bifid ribs, a combination which is now frequently known as Gorlin-Goltz syndrome as well as Nevoid Basal Cell Carcinoma Syndrome (NBCCS. NBCCS is inherited as an autosomal dominant trait with high penetrance and variable expressivity. NBCCS is characterized by variety of cutaneous, dental, osseous, opthalmic, neurologic and sexual abnormalities. One such case of Gorlin-Goltz syndrome is reported here with good illustrations.

  10. Som, fúria, crítica e audiência: aspectos da recepção da série Som & fúria, de Fernando Meirelles

    Directory of Open Access Journals (Sweden)

    Marcelo de Lima

    2016-07-01

    Full Text Available Este artigo procura analisar aspectos da recepção da minissérie Som & fúria, exibida pela Rede Globo de Televisão em 2009. Produzida em conjunto com a O2 Filmes, a minissérie narra a história de uma trupe teatral que adapta obras do dramaturgo inglês William Shakespeare. Ao mesmo tempo em que recebeu críticas extremamente positivas da crítica jornalística, Som & fúria alcançou baixos números de audiência para os padrões da Globo, o que levou a seu cancelamento após apenas uma temporada. Consideramos que as referências à literatura shakespeariana e a presença da linguagem teatral na minissérie podem ter provocado um ruído de comunicação com o público, minimizando, assim, as possibilidades de diálogo e de construção de uma relação afetiva entre o programa e uma audiência mais abrangente. Utilizamos principalmente os conceitos de dialogismo e carnavalização (BAKHTIN, 2010; STAM, 1992 e a abordagem cognitivista aplicada a produtos audiovisuais (BORDWELL, 2007; PUCCI, 2012 na tentativa de compreender essa discrepância entre a recepção do público e da crítica. Procuramos contribuir, assim, para os estudos de recepção de audiovisuais, considerando os diversos atores que compõem o público e seus locus recepcionais, suas particularidades e as influências que determinam a forma através qual eles se relacionam com produtos culturais diversos.

  11. Expressão da E-caderina em carcinoma de células escamosas e no tumor de células basais de cães E-cadherin expression in squamous cell carcinoma and basal cell tumors in dogs

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    Carolina Franchi João

    2011-09-01

    Full Text Available As caderinas compreendem uma classe de moléculas de adesão celular expressa na superfície de todas as camadas epidérmicas. A E-caderina é a principal caderina envolvida na adesão celular epitelial. A redução de sua expressão está envolvida na progressão de alguns tipos de câncer, no potencial metastático e ainda na definição do prognóstico, principalmente nos carcinomas. O carcinoma de células escamosas e o tumor de células basais são neoplasias cutâneas malignas que afetam os cães. O objetivo deste estudo foi avaliar a expressão da E-caderina no carcinoma de células escamosas (n=20 e no tumor de células basais (n=15, buscando-se relacionar sua expressão ao comportamento biológico desses tumores. Os carcinomas de células escamosas apresentaram significativa redução da expressão da molécula comparado aos tumores de células basais, quando avaliado pelo teste de Fisher (P=0,0039. Também foi observado que células neoplásicas mais diferenciadas apresentaram coloração mais intensa que as menos diferenciadas. Em conclusão, sugere-se que a expressão reduzida da E-caderina em tumores cutâneos pode indicar maior poder infiltrativo e consequentemente mau prognóstico na espécie canina.The cadherins are a group of cellular adhesion molecules that are expressed on the surface of all epidermic layer. The E-cadherin is the main cadherin involved in epithelial cellular adhesion; the decrease in its expression is related to the progression of some types of cancer, to its metastatic characteristics, and to the prognosis, specially carcinomas. The squamous cell carcinoma and the basal cells tumors are a malignant epithelial neoplasm which affects dogs. The goal of this study was to evaluate E-cadherin's expression in canine tissues that were classified as squamous cell carcinoma or basal cell tumor, and to find a correlation with the biological behavior of the tumors. The squamous cell carcinomas showed significantly

  12. Forholdet mellem public relations og marketing som ledelsesfunktioner

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    James E. Grunig

    1993-09-01

    Full Text Available I forsommeren 1993 tildelte Dansk Public Relations Forening årets PR- pris til mesterkommunikatøren Lars Larsen, Jysk Sengetøjslager/Larsen Rejser. I motiveringen hedder det, at Lars Larsen hædres for "en prisvær- dig Public Relations indsats, der kan motivere til en øget anvendelse af Public Relations i den danske forretningsverden". Blandt PR-foreningens medlemmer vakte pristildelingen en vis furore; et indlæg i foreningens blad PRspektiv invendte, at Lars Larsen driver "publicity" (dvs. et reklame- værktøj - "Præcis den slags PR, som vi i mange år har arbejdet på at distancere Public Relation-begrebet fra". Lars Larsen selv sagde, at han slet ikke skelner mellem Public Relations, PR og markedsføring. Et andet indlæg i bladet argumenterede for, at det ikke længere giver mening at adskille begreberne Public Relations og markedsføring, fordi grænsen mellem det offentlige og det private ude i virkeligheden er mere og mere flydende. James Grunigs artikel, der søger at afklare forholdet mellem PR og marketing teoretisk og praktisk, er derfor brændende aktuelt, ikke mindst for PR-fagets bestræbelser på at blive anerkendt som en respek- tabel profession. Den blev præsenteret som foredrag under Grunigs Dan- marksbesøg i marts 1993, er redigeret af Kim Schrøder og oversat fra engelsk af Kenja Henriksen.

  13. John Deweys pædagogik som filosofisk livskunst

    DEFF Research Database (Denmark)

    Dræby, Anders

    De senere år har der været forøget fokus på John Deweys slægtskab med antikkens filosofiske tradition. Oplægget stiller i den forbindelse skarpt på spørgsmålet om, hvorvidt og hvordan det giver mening at forstå Deweys pædagogiske filosofi i sammenhæng med Hellenismens og Romerrigets filosofiske...... livskunst. Er det med andre ord muligt at begribe Deweys pædagogik som en særlig form for filosofisk livskunst?...

  14. Desenvolvimento motor e crescimento somático de crianças com diferentes contextos no ensino infantil

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    Décio Rodrigues

    2013-09-01

    Full Text Available O objetivo deste estudo foi verificar os efeitos de diferentes contextos no desenvolvimento das habilidades motoras fundamentais e no crescimento somático de crianças no ensino infantil. Participaram deste estudo 50 crianças: 25 tiveram educação física com um professor da área e 25 crianças tiveram atividades com o professor responsável pela turma. Crianças foram avaliadas no início e final do ano letivo quanto a dados antropométricos, dobras cutâneas, medidas de atividade física e realizaram os subtestes do TGMD-2. No início do ano letivo, nenhuma diferença foi observada entre os grupos. No final do ano letivo, crianças que tiveram atividades com o professor da sala apresentaram redução no nível de atividade física, enquanto que crianças com educação física com o professor especialista apresentaram manutenção no nível de atividade física e melhor desenvolvimento das habilidades motoras. O envolvimento em diferentes contextos de aulas de educação física não é suficiente para promover alteração somática em crianças ao longo do ano letivo. Entretanto, educação física com o professor especialista melhora o desenvolvimento das habilidades motoras fundamentais e promove manutenção do nível de atividade física em crianças no ensino infantil.

  15. Med sjefen på Facebook: En studie av ledere som er "venner" med sine ansatte

    OpenAIRE

    Jensen, Anita

    2014-01-01

    MR690 Masteroppgave i organisasjon og ledelse - utdanningsledelse Formålet med studien er å belyse hvordan aktiv bruk av sosiale medier, i dette tilfellet Facebook, påvirker relasjoner mellom mennesker. Hva skjer når en tar i bruk en websjanger som i utgangspunktet er umiddelbar og uformell, til jobbrelatert og mer formell kommunikasjon? Er det sjangeren eller relasjonen som endres? Søkelyset rettes mot ledere som er “venner” med sine medarbeidere, og problemstillingen er...

  16. Validering som kommunikationsfärdighet till par där kvinnan har vaginism

    OpenAIRE

    Bernling, Marit; Munck af Rosenschöld, Lisa

    2009-01-01

    Vaginism är ett sexuellt problem som förekommer hos kvinnor och som i tidigare utvärderade behandlingar betraktats som kvinnans problem. Forskning inom området vaginism är begränsad och kunskap om parrelationens roll för vidmakthållandet av problematiken och upplevd relationstillfredsställelse saknas. Studiens syfte var att utforma en parbehandling där kommunikationsinterventionen validering lärs ut som färdighet, utforska om det fanns ett intresse för deltagande, samt utvärdera om behandling...

  17. Studerendes caseundersøgelser som omdrejningspunkt for forskningsbaseret holdundervisning

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    Nina Bonderup Dohn

    2013-03-01

    Full Text Available Artiklen indledes med en diskussion af, hvori forskningsbaseret undervisning (FU består. Vi bestemmer FU som undervisning, hvor studerende involveres som aktive deltagere i processen med at producere ny viden ved brug af forskningsmetode. Vores overordnede forskningsspørgsmål lyder: Hvilke muligheder giver et didaktisk design baseret på, at de studerende inddrages som bidragydere til forskningsprocessen, for at realisere de forskellige begrundelser for forskningsbaseret undervisning? Hvilke problemstillinger viser der sig i forsøget herpå? Spørgsmålet undersøges med fokus på læringsteoretiske begrundelser og filosofiske begrundelser for FU. Vi rapporterer resultater fra et følgeforskningsprojekt i et undervisningsforløb, designet ud fra vores bestemmelse af FU. I diskussionen argumenterer vi for, at de læringsteoretiske begrundelser har rimelige muligheder for at realiseres med det didaktiske design, mens de filosofiske begrundelser kræver mere understøttelse. Resultaterne peger på en række problemstillinger og barrierer for realiseringen af FU (i en bestemmelse som vores og af begrundelserne for FU. Blandt disse er, at det didaktiske design indebærer en uvant arbejds- og studieform for de studerende, at der kan være en spænding mellem studieordningens faglige mål og FU (i en bestemmelse som vores, og at studerendes instrumentalistiske, erhvervsrettede mål kan være en barriere for realisering af de filosofiske begrundelser for FU. The article starts with a short discussion of different views on research-based teaching (RT. We characterize RT as teaching where students are involved as active participants in the process of producing new knowledge through the use of research methods. Our overall research question is: What possibilities does a pedagogical design based on involving students as contributors to the research process offer for realizing the different reasons for RT? What problems can arise? The research question

  18. Litteraturarbete i ett svenska som andraspråksklassrum

    Directory of Open Access Journals (Sweden)

    Catarina Economou

    2015-06-01

    Full Text Available AbstractThis article considers the role of reading fiction in Swedish as a second language instruction. The study examines how a group of advanced second language learners in a Swedish upper secondary school read, interpret and discuss a contemporary Swedish novel, how they interact with the text and with each other in relation to the text. Furthermore, it analyses which forms of reading the students use. It is a qualitative, empirical study based on field studies, transcriptions of tape recorded interaction and of written texts. The results indicate that second language learners in this context have a positive attitude towards reading and discussing what they read using several forms of reading. They often compare the content of the text to their own lives. One conclusion is that literature teaching and literature can be integrated into one Swedish subject in order to create even more meaningful interactions between students from different backgrounds. Another is that literature can be a means of language development as well as personal development.Keywords: Second language learners, literature pedagogy and didactics, forms of reading, democracy. SammandragDenna artikel handlar om skönlitteraturens roll i skolämnet svenska som andraspråk. Studien undersöker hur en grupp avancerade andraspråksinlärare i en svensk gymnasieskola läser, tolkar och diskuterar en modern svensk roman och hur de interagerar med texten och med varandra i relation till texten. Dessutom analyseras vilka läsarter som eleverna använde sig av. Den är en kvalitativ, empirisk studie som baseras på fältstudier, transkriptioner av inspelade boksamtal och elevtexter. Resultaten visar att andraspråkseleverna hade en positiv attityd till boksamtal och de använde sig av flera läsarter. De jämförde ofta texten till sina egna liv och erfarenheter.  En slutsats är att litteraturundervisning och litteraturarbete skulle kunna integreras i ett gemensamt ämne så att

  19. Fjernsynet som shaman: Om store mediebegivenheders transformative virkninger

    Directory of Open Access Journals (Sweden)

    Daniel Dayan

    1988-08-01

    Full Text Available Den direkte transmission af levende begivenheder har altid været TV- mediets særlige styrke, hvad enten det drejer sig om fodboldkampe, Lørdagskanalen eller kongebrylluper. Medieforskerne har da også interesseret sig for fjernsynets formidling af sportsbegivenheder og der er blevet lavet analyser af Kanaludsendelserne. Men hverken i Danmark eller andre steder har forskerne fundet det interessant at undersøge de store, ceremonielle mediebegivenheder. Det er Dayan & Katz´ projekt at udfylde dette tomrum i medie- og kul- turforskningen: Hvad er det, der fascinerer millioner ved disse TV- ceremonier, der ofte ikke blot henvender sig til et enkelt lands seere, men transmitteres til og ses af store dele af verden? Hvordan fungere disse begivenheder - hvad enten det drejer sig om Præsident Kennedys begravelse, Sadats besøg i Jerusalem, Månelandingen eller Watergate- høringerne - ideologisk, og hvilke interesser tjener de dermed i den politiske offentlighed? I denne artikel, der er et bearbejdet uddrag af den bog, projektet skal munde ud i, beskæftiger Dayan & Katz sig især med det de kalder "transformative" mediebegivenheder, dvs. TV-ceremonier der markerer, at et samfund står ved en tærskel mellem den herskende orden og en ny mulig orden, og som selv er et aktivt og aktiverende bidrag til forvand- lingen af kulturelle opfattelser og værdier. Artiklens perpektiv er udpræget tværvidenskabeligt, idet der trækkes på såvel kulturantropologiske (Levi-Strauss, Geertz, Turner som filosofiske (Bakhtin, Baudrillard, sprogteoretiske (Austin og traditionelt samfunds- videnskabelige/mediesociologiske (Boorstin arbejder. I artiklens første halvdel foretages der en afgrænsning af transformative over for andre ceremonielle begivenheder. I anden halvdel gennemgås de fem faser, som udgør transformative begivenheders typiske struktur. Artiklen er bearbejdet af Jørgen Bang og Kim Schrøder. Den er oversat af Kim Schrøder.

  20. Primeira transferência: afastar a sugestão do somático

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    François Villa

    2008-12-01

    Full Text Available Além da simpatia, da empatia, na origem da neurose de transferência, há um ponto central, ponto de antipatia, em que psicanalista e psicanalisando apreendem o real do corpo. Além do corpo psíquico, se entrevê o fundo das coisas: a carne em sofrimento que nunca é vista. Nesse momento do tratamento ouve-se a força de atração do recalcamento orgânico. O autor volta a um momento princeps da invenção freudiana: o sonho "da injeção de Irmã", para examinar sua hipótese de que o trabalho do sonho revela uma das funções do psíquico - afastar a sugestão do somático.First transference: des-suggesting the somatic. In the origin of transference neurosis, beyond sympathy and empathy, we can meet an umbilical point, which is an antipathy point where patient and analyst encounter the real of the body. Beyond the psychic body, we can see "the bottom of things": the suffering flesh, which is never seen. This moment of cure is the one where can be heard the strength of attraction from the organic repression. In order to explore this hypothesis, the author goes back to a moment of Freudian finding: the dream of Irma. He suggests that the work of the dream shows a function of the psychic, which is the desuggestion of somatic.

  1. The human airway epithelial basal cell transcriptome.

    Directory of Open Access Journals (Sweden)

    Neil R Hackett

    2011-05-01

    Full Text Available The human airway epithelium consists of 4 major cell types: ciliated, secretory, columnar and basal cells. During natural turnover and in response to injury, the airway basal cells function as stem/progenitor cells for the other airway cell types. The objective of this study is to better understand human airway epithelial basal cell biology by defining the gene expression signature of this cell population.Bronchial brushing was used to obtain airway epithelium from healthy nonsmokers. Microarrays were used to assess the transcriptome of basal cells purified from the airway epithelium in comparison to the transcriptome of the differentiated airway epithelium. This analysis identified the "human airway basal cell signature" as 1,161 unique genes with >5-fold higher expression level in basal cells compared to differentiated epithelium. The basal cell signature was suppressed when the basal cells differentiated into a ciliated airway epithelium in vitro. The basal cell signature displayed overlap with genes expressed in basal-like cells from other human tissues and with that of murine airway basal cells. Consistent with self-modulation as well as signaling to other airway cell types, the human airway basal cell signature was characterized by genes encoding extracellular matrix components, growth factors and growth factor receptors, including genes related to the EGF and VEGF pathways. Interestingly, while the basal cell signature overlaps that of basal-like cells of other organs, the human airway basal cell signature has features not previously associated with this cell type, including a unique pattern of genes encoding extracellular matrix components, G protein-coupled receptors, neuroactive ligands and receptors, and ion channels.The human airway epithelial basal cell signature identified in the present study provides novel insights into the molecular phenotype and biology of the stem/progenitor cells of the human airway epithelium.

  2. 'Black star': uma mutação somática natural da uva fina de mesa cv. Brasil

    OpenAIRE

    Roberto,Sergio Ruffo; Assis,Adriane Marinho de; Genta,Werner; Yamamoto,Lilian Yukari; Sato,Alessandro Jefferson

    2012-01-01

    A uva fina de mesa 'Black Star', originada de uma mutação somática da uva cv. Brasil em Marialva-PR, é descrita quanto às suas principais características físico-químicas e produtivas. Suas bagas, com sementes, apresentam formato elipsoide alongado com coloração vermelho-escura, tendendo ao preto durante a maturação plena. O ciclo, o desempenho produtivo e a suscetibilidade às doenças fúngicas assemelham-se aos da cv. Itália. Durante a maturação plena, apresenta teor médio de sólidos solúveis ...

  3. Basal cell carcinoma-treatment with cryosurgery

    Directory of Open Access Journals (Sweden)

    Kaur S

    2003-03-01

    Full Text Available Basal cell carcinoma is a common cutaneous malignancy, frequently occurring over the face in elderly individuals. Various therapeutic modalities are available to treat these tumors. We describe three patients with basal cell carcinoma successfully treated with cryosurgery and discuss the indications and the use of this treatment modality for basal cell carcinomas.

  4. Cintilografia do miocárdio com tecnécio 99m-MIBI e administração de adenosina em portadores de doença arterial coronária: correlação dos resultados com a angiografia coronária e o ultra-som intracoronário Adenosine myocardial perfusion SPECT with Tc-99m-MIBI in patients with obstructive coronary artery disease: correlation between quantitative coronary angiography and intravascular ultrasound measurements

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo Mastrocolla

    2006-01-01

    Full Text Available OBJETIVO: Estabelecer a correlação da cintilografia de perfusão do miocárdio (CPM com Tecnécio 99m-MIBI (MIBI e injeção de adenosina, empregando a angiografia coronária quantitativa (ACQ e o ultra-som intracoronário (UIC como comparação. MÉTODOS: Estudo de 70 pacientes com doença arterial coronária (DAC, encaminhados à CPM com MIBI e adenosina. As manifestações clínicas, do eletrocardiograma (ECG e os resultados das imagens foram correlacionadas às variáveis da análise visual e quantitativa da angiografia, bem como ao UIC. RESULTADOS: A média de idades foi de 60,6 anos, com 39 pacientes do sexo masculino. A angiografia coronária evidenciou estenose do diâmetro da luz (E% de 49,94% em 105 artérias, com reavaliação à ACQ em 83 artérias (79% e média de 44,20%, pOBJECTIVE: To correlate myocardial perfusion scintigraphy (MPS with Tc-99m-MIBI and adenosine infusion using quantitative coronary angiography (QCA and intravascular ultrasound (IVUS. METHODS: Seventy patients with coronary artery disease (CAD referred for myocardial perfusion scintigraphy (MPS with MIBI and adenosine were studied. Clinical, electrocardiographic (ECG, and scintigraphic findings were correlated with variables of visual and quantitative angiographic analysis, as well as to those of IVUS. RESULTS: The mean age of patients was 60.6 years, and 39 were male. Coronary angiography showed percentage of diameter stenosis (% DS of 49.94% in 105 arteries, 83 of which were re-evaluated by QCA (79%, mean of 44.20%, p<0.05. ST-segment depression during adenosine infusion was associated with higher degrees of % DS (55.0% vs. 47.8%, p<0.05. Scintigraphic ischemia was correlated with greater cross-sectional area of lumen obstruction by IVUS (% CSA. Clinical, ECG, and IVUS findings were considered together and expressed as global ischemic versus non-ischemic responses. Ischemia was associated with lower values of minimal lumen diameter (MLD and minimal lumen area

  5. ADHD SOM SOCIALT OG KULTURELT FÆNOMEN

    DEFF Research Database (Denmark)

    Berger, Nichlas Permin

    Der har i Danmark de seneste årtier været en eksplosiv vækst i antallet af mennesker, der stilles en ADHD-diagnose. Der eksisterer et væld af forskellige bud på forklaringer på dette fænomen. Lige fra epidemiologiske og medicinske tolkninger, der peger på, at mennesker generelt er blevet mere syge...... at forbinde psykiske lidelser, herunder i væsentlig grad ADHD, som en risikofaktor for kriminalitet, antisocial adfærd, misbrug og en række andre sociale problemer. Med interesse i dette komplekse fænomen belyses empirisk den sociale og kulturelle forudsætning for ADHD-diagnosen i Kriminalforsorgens...... institutioner i en kulturanalytisk og socialkonstruktivistisk optik. Afhandlingen undersøger, hvordan ADHD og kriminalitet diskursivt kobles sammen af voksne kriminelle med en ADHD-diagnose og frontmedarbejdere i Kriminalforsorgen....

  6. Claus Beck-Nielsen som spøgelse

    DEFF Research Database (Denmark)

    Larsen, Peter Stein

    2012-01-01

    Med Brian Grahams artikel “Sympathy for the Spectres: The Double Nature of Blake’s Spectral Figures in Jerusalem” forbliver vi inden for den litterære tradition, men bevæger os en smule længere frem i tiden. Graham retter blikket mod William Blakes forfatterskab og påpeger, at Blakes univers er...... feministisk synsvinkel – er spøgelserne dobbelte: de spiller en rolle i kristendommens historie, samtidig med at de spiller en kontrasterende sympatisk rolle i den universelle strid mellem Blakes ”male and female powers”, denne evige strid mellem disse to poler ses af Blake som grundlaget for al skabelse og...

  7. Løgnene er ikke så nemme at huske som sandheden

    DEFF Research Database (Denmark)

    Bertelsen, Bettina

    2005-01-01

    Formålet med denne artikel er at belyse og diskutere, hvordan og hvorvidt prostituion kan forstås som et socialt problem. Dette vil jeg gøre gennem en teoretisk diskussion og analyse af prostitution som et socialt problem belyst ud fra konkrete projekterfaringer. Erfaringerne stammer dels fra...

  8. Gruppen som container og potentielt læringsrum gennem refleksion

    DEFF Research Database (Denmark)

    Søbirk, Helle Henni

    2012-01-01

    Al psykomotorisk intervention foregår i en relation mellem den psykomotoriske terapeut og individ eller gruppe. Derfor anses relations- og refleksionskompetencer som fagpersonlige kernekompetencer i den psykomotoriske praksis og er et centralt formål med "anvendte grupper" som hhv. udviklings-, t...

  9. Lekfull kreativitet. Fysiska användargränssnitt som erbjuder social och fysisk interaktion

    DEFF Research Database (Denmark)

    Brooks, Eva Irene

    2017-01-01

    I den här artikeln presenteras en studie som ägde rum under två år i fem olika förskolor i Danmark och som inkluderade 55 barn. Specifikt undersökte vi hur fysiska användargränssnitt kan stötta social och fysisk interaktion. Studien applicerade en design-baserad metodologi som följde en iterativ,......, cyklisk process. Analysen visade att fysiska gränssnitt som främjar utforskande aktiviteter, verbala interaktioner och samarbete har en potential att erbjuda lekfulla lärande situationer som understödjer fria men också guidade aktiviteter....

  10. Genetic activation, inactivation and deletion reveal a limited and nuanced role for somatostatin-containing basal forebrain neurons in behavioral state control.

    Science.gov (United States)

    Anaclet, Christelle; De Luca, Roberto; Venner, Anne; Malyshevskaya, Olga; Lazarus, Michael; Arrigoni, Elda; Fuller, Patrick M

    2018-05-07

    Recent studies have identified an especially important role for basal forebrain GABAergic (BF VGAT ) neurons in the regulation of behavioral waking and fast cortical rhythms associated with cognition. However, BF VGAT neurons comprise several neurochemically and anatomically distinct sub-populations, including parvalbumin- and somatostatin-containing BF VGAT neurons (BF Parv and BF SOM ), and it was recently reported that optogenetic activation of BF SOM neurons increases the probability of a wakefulness to non-rapid-eye movement (NREM) sleep transition when stimulated during the animal's rest period. This finding was unexpected given that most BF SOM neurons are not NREM sleep active and that central administration of the synthetic SOM analog, octreotide, suppresses NREM sleep or increases REM sleep. Here we employed a combination of genetically-driven chemogenetic and optogenetic activation, chemogenetic inhibition and ablation approaches to further explore the in vivo role of BF SOM neurons in arousal control. Our findings indicate that acute activation or inhibition of BF SOM neurons is neither wakefulness- nor NREM sleep-promoting, is without significant effect on the EEG, and that chronic loss of these neurons is without effect on total 24h sleep amounts, although a small but significant increase in waking was observed in the lesioned mice during the early active period. Our in vitro cell recordings further reveal electrophysiological heterogeneity in BF SOM neurons, specifically suggesting at least two distinct sub-populations. Taken together our data support the more nuanced view that BF SOM are electrically heterogeneous and are not NREM sleep- or wake-promoting per se , but may exert, in particular during the early active period, a modest inhibitory influence on arousal circuitry. SIGNIFICANCE STATEMENT The cellular basal forebrain (BF) is a highly complex area of the brain that is implicated in a wide-range of higher-level neurobiological processes

  11. Migraine attacks the Basal Ganglia

    Directory of Open Access Journals (Sweden)

    Bigal Marcelo

    2011-09-01

    Full Text Available Abstract Background With time, episodes of migraine headache afflict patients with increased frequency, longer duration and more intense pain. While episodic migraine may be defined as 1-14 attacks per month, there are no clear-cut phases defined, and those patients with low frequency may progress to high frequency episodic migraine and the latter may progress into chronic daily headache (> 15 attacks per month. The pathophysiology of this progression is completely unknown. Attempting to unravel this phenomenon, we used high field (human brain imaging to compare functional responses, functional connectivity and brain morphology in patients whose migraine episodes did not progress (LF to a matched (gender, age, age of onset and type of medication group of patients whose migraine episodes progressed (HF. Results In comparison to LF patients, responses to pain in HF patients were significantly lower in the caudate, putamen and pallidum. Paradoxically, associated with these lower responses in HF patients, gray matter volume of the right and left caudate nuclei were significantly larger than in the LF patients. Functional connectivity analysis revealed additional differences between the two groups in regard to response to pain. Conclusions Supported by current understanding of basal ganglia role in pain processing, the findings suggest a significant role of the basal ganglia in the pathophysiology of the episodic migraine.

  12. Ultra-som terapêutico na cicatrização tecidual Therapeutic ultrasound in the tissue healing

    Directory of Open Access Journals (Sweden)

    Débora Cristina Olsson

    2008-08-01

    Full Text Available Visando a minimizar o período de tratamento cicatricial em diversos tecidos, buscam-se alternativas à terapia convencional que colaborem com o processo reparativo criando um microambiente ideal para sua ocorrência. Dentre os inúmeros benefícios das técnicas aplicáveis à medicina regenerativa, o ultra-som terapêutico (UST é prática adjuvante cada vez mais freqüente. Os modelos experimentais de terapia sonora em animais têm propiciado informações relevantes para o tratamento de vários tipos de lesões; todavia, apesar de serem muito utilizados, ainda existem controvérsias em relação aos seus potenciaia biológicos de acordo com a modalidade e a dosimetria indicadas para cada caso. Os efeitos biofísicos do ultra-som (US sobre o reparo tecidual são pouco compreendidos, sendo seu uso muitas vezes negligenciado ou fundamentado na experiência prática, o que resulta em procedimentos errôneos. O objetivo desta revisão bibliográfica é apresentar informações sobre o UST, relatar a existência de riscos de danos celulares decorrentes da inadequada aplicação e revelar a importância de seus mecanismos de ação nos tecidos, tanto no sentido físico, como nos seus aspectos biológicos.Aiming to minimize the cicatricial treatment period, alternatives have been searched to conventional therapy, among which the therapeutic ultrasound is a practice more and more frequent. However, despite of being used in the treatment of various lesions types, there are still controversies related to its real therapeutical value and the indicated dosimetry for each case. The ultrasound effect on the tissue repair is little understood, and its use is seldom based on the practical experience, what sometimes results in wrong procedures. This review has the objective to show the therapeutic ultrasound information and to reveal the importance of its mechanisms in the tissues in the physical and biological aspects.

  13. Deep SOMs for automated feature extraction and classification from big data streaming

    Science.gov (United States)

    Sakkari, Mohamed; Ejbali, Ridha; Zaied, Mourad

    2017-03-01

    In this paper, we proposed a deep self-organizing map model (Deep-SOMs) for automated features extracting and learning from big data streaming which we benefit from the framework Spark for real time streams and highly parallel data processing. The SOMs deep architecture is based on the notion of abstraction (patterns automatically extract from the raw data, from the less to more abstract). The proposed model consists of three hidden self-organizing layers, an input and an output layer. Each layer is made up of a multitude of SOMs, each map only focusing at local headmistress sub-region from the input image. Then, each layer trains the local information to generate more overall information in the higher layer. The proposed Deep-SOMs model is unique in terms of the layers architecture, the SOMs sampling method and learning. During the learning stage we use a set of unsupervised SOMs for feature extraction. We validate the effectiveness of our approach on large data sets such as Leukemia dataset and SRBCT. Results of comparison have shown that the Deep-SOMs model performs better than many existing algorithms for images classification.

  14. Multi-SOM: an Algorithm for High-Dimensional, Small Size Datasets

    Directory of Open Access Journals (Sweden)

    Shen Lu

    2013-04-01

    Full Text Available Since it takes time to do experiments in bioinformatics, biological datasets are sometimes small but with high dimensionality. From probability theory, in order to discover knowledge from a set of data, we have to have a sufficient number of samples. Otherwise, the error bounds can become too large to be useful. For the SOM (Self- Organizing Map algorithm, the initial map is based on the training data. In order to avoid the bias caused by the insufficient training data, in this paper we present an algorithm, called Multi-SOM. Multi-SOM builds a number of small self-organizing maps, instead of just one big map. Bayesian decision theory is used to make the final decision among similar neurons on different maps. In this way, we can better ensure that we can get a real random initial weight vector set, the map size is less of consideration and errors tend to average out. In our experiments as applied to microarray datasets which are highly intense data composed of genetic related information, the precision of Multi-SOMs is 10.58% greater than SOMs, and its recall is 11.07% greater than SOMs. Thus, the Multi-SOMs algorithm is practical.

  15. Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [NPY]) during postnatal development.

    Science.gov (United States)

    Cebada-Sánchez, S; Insausti, R; González-Fuentes, J; Arroyo-Jiménez, M M; Rivas-Infante, E; Lagartos, M J; Martínez-Ruiz, J; Lozano, G; Marcos, P

    2014-10-01

    The postnatal development of the human hippocampal formation establishes the time and place at which we start autobiographical memories. However, data concerning the maturation of the neurochemical phenotypes characteristic of interneurons in the human hippocampus are scarce. We have studied the perinatal and postnatal changes of the dentate gyrus (DG) interneuron populations at three rostrocaudal levels. Immunohistochemically identified neurons and fibers for somatostatin (SOM-12 and SOM-28) and neuropeptide Y (NPY) and the co-localization of SOM-28 and NPY were analyzed. In total, 13 cases were investigated from late pregnancy (1 case), perinatal period (6 cases), first year (1 case), early infancy (3 cases), and late infancy (2 cases). Overall, the pattern of distribution of these peptides in the DG was similar to that of the adult. The distribution of cells was charted, and the cell density (number of positive cells/mm(2)) was calculated. The highest density corresponded to the polymorphic cell layer and was higher at pre- and perinatal periods. At increasing ages, neuron density modifications revealed a decrease from 5 postnatal months onward. In contrast, by late infancy, two immunoreactive bands for SOM-28 and NPY in the molecular layer were much better defined. Double-immunohistochemistry showed that NPY-positive neurons co-localized with SOM-28, whereas some fibers contained only one or other of the neuropeptides. Thus, this peptidergic population, presumably inhibitory, probably has a role in DG maturation and its subsequent functional activity in memory processing.

  16. Utholdenhetstrening i fotball: En analyse av smålagsspill brukt som utholdenhetstrening

    OpenAIRE

    Lorvik, Knut

    2013-01-01

    Utholdenhet er en fysisk egenskap som har betydning for fotballprestasjonen. Det viser flere studier. Helgerud (et al. 2001) fant signifikante forbedringer i forhold til flere fysiske mål som ble testet. Impellizzeri (et al. 2008) fant i sin studie at en forbedring i VO2max påvirket kortpasningsferdighetene positivt. I denne oppgaven har jeg fokusert på utholdenhetstrening i fotball og har to problemstillinger. Den første problemstillingen handler om hvilke studier som er gjort av utholde...

  17. Børn med diagnoser som pædagogisk-psykologisk udfordring

    DEFF Research Database (Denmark)

    Bøttcher, Louise

    2013-01-01

    hovedsageligt vanskelighederne ud fra en social vinkel. Den artikels dialektiske balancegang mellem de to positioner vil udfolde en forståelse af diagnoser som ADHD eller autismespektrumforstyrrelser, som tager udgangspunkt i at en eller flere biologiske afvigelser meget vel kan være den oprindelige årsag til...... hvordan uoverensstemmelsen mellem barnet og omgivelserne skaber problemer og udfordringer, kan diagnosen blive nyttig. Nemlig som dialektisk redskab til at analysere de psykologiske og pædagogiske udviklingsmæssige konsekvenser af at have en psykisk udviklingsforstyrrelse af typen ASD eller ADHD – frem...

  18. Fiskeren som forsvant? En studie av avfolking, overbefolking og endringsprosesser i norsk fiskerinæring

    OpenAIRE

    Johnsen, Jahn Petter

    2003-01-01

    Hva er en fisker? Dette er det sentrale spørsmålet i denne avhandlinga. Spørsmålet er utgangspunkt for å utforske endringsprosesser i fiskerinæringa, både i fortida og i samtida. På bakgrunn av dette drøfter avhandlinga hvilke oppfatninger, forståelser og beskrivelser som til enhver tid benyttes til å definere hva fiskere er i ulike sammenhenger. Undersøkelsen starter i det som kan kalles rekrutteringsdiskursen i fiske, som nettopp handler om hva fiskere er og hvordan de skapes...

  19. Positron emission tomography and basal ganglia functions

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Motohiro; Otsuka, Makoto; Taniwaki, Koukyo; Hosokawa, Shinichi; Kuwabara, Yasuo; Ichiya, Yuichi [Kyushu Univ., Fukuoka (Japan). Faculty of Medicine

    1990-05-01

    With the advent of positron emission tomography (PET), studies on the human brain function and pathophysiology of brain damage have been extremely progressed. It is well-known that the basal ganglia plays an important role as one of the central nervous system involved in exercise regulation. More recently, the potential involvement of the basal ganglia in psychological processes, such as cognitive function, has been pointed out, receiving much attention. In spite of such a lot of studies, however, basal ganglia function remains unclear. This paper describes the relationships between PET findings and basal ganglia function. PET findings are discussed in relation to brain energy metabolism and striatal dopamine function. Pathophysiology of the basal ganglia are described in terms of the following diseases: Parkinson's disease, Parkinson's syndrome, progressive supranuclear palsy, Huntington's disease, and dystonia. Physiological backgrounds of the basal ganglia for PET images are also referred to. (N.K.) 75 refs.

  20. Positron emission tomography and basal ganglia functions

    International Nuclear Information System (INIS)

    Kato, Motohiro; Otsuka, Makoto; Taniwaki, Koukyo; Hosokawa, Shinichi; Kuwabara, Yasuo; Ichiya, Yuichi

    1990-01-01

    With the advent of positron emission tomography (PET), studies on the human brain function and pathophysiology of brain damage have been extremely progressed. It is well-known that the basal ganglia plays an important role as one of the central nervous system involved in exercise regulation. More recently, the potential involvement of the basal ganglia in psychological processes, such as cognitive function, has been pointed out, receiving much attention. In spite of such a lot of studies, however, basal ganglia function remains unclear. This paper describes the relationships between PET findings and basal ganglia function. PET findings are discussed in relation to brain energy metabolism and striatal dopamine function. Pathophysiology of the basal ganglia are described in terms of the following diseases: Parkinson's disease, Parkinson's syndrome, progressive supranuclear palsy, Huntington's disease, and dystonia. Physiological backgrounds of the basal ganglia for PET images are also referred to. (N.K.) 75 refs

  1. Specialestuderendes læringsudfordringer i vejledningen - nudging som handlemulighed

    Directory of Open Access Journals (Sweden)

    Hanne Nexø Jensen

    2015-03-01

    Full Text Available Specialeskrivere møder læringsudfordringer i skriveprocessen. Hvilke læringsudfordringer, det er, og hvordan studerende og vejledere hånd-terer dem, er artiklens fokus. Empirien er videooptagede vejlednings-møder, hvor der er minimum to optagelser for hver vejleder og stude-rendes forløb. Det teoretiske afsæt er generiske læringsudfordringer i vejledningsprocesser, hvor læring opstår, når de studerende passerer en læringsudfordring. Vejledere kan bruge forståelsen af læringsudfor-dringer til at ”nudge”- plante en idé – som en måde at få studerende til at passere læringsudfordringerne. MA students writing up their final theses encounter a variety of conceptual thresholds during the process. The focus of this article is the identification of different kinds of conceptual threshold, and how the students overcome these obstacles. Video recordings of student supervision meetings provide the data for the analysis. For each supervisor – supervisee at least two recordings are considered. We go on to discuss how supervisors can make use of a conceptual thresholds approach, and nudge students in ways that will help them move on more easily.

  2. Overskridende læring - ADHD problematikken som eksempel

    DEFF Research Database (Denmark)

    Kristensen, Karen-Lis; Mørck, Line Lerche

    2011-01-01

    ADHD er en problematik, der i tiltagende grad fylder i medierne, i forældres bevidsthed, i klasseværelserne, i PPR-praksis og i den specialpædagogiske indsats. ADHD-problematikken er omstridt, og der er således mange forskellige perspektiver på, hvordan vi skal forstå ADHD. Er det udtryk for en...... patologisering af uro? Eller er der tale om genetisk betingede kognitive vanskeligheder med opmærksomhed og impulskontrol? Skyldes ADHD en forkert produktion og koncentration af sporstoffer i hjernen? Eller skyldes det, at kreativitet ikke i samme grad som tidligere kan rummes i skolernes klasseværelser? Er der...... handlesammenhæng, hvor de deltager” (Højholt, 1996: 62), søger vores tilgang på engang bedre både at forstå og fremme børns udvikling. Efter introduktion af teori om overskridende læring eksemplificerer vi tilgangen med to empiriske cases om 5. klasse-drengen, Anton, der ikke ønsker at tage sin medicin mod ADHD og...

  3. Specialestuderendes læringsudfordringer i vejledningen - nudging som handlemulighed

    Directory of Open Access Journals (Sweden)

    Hanne Nexø Jensen

    2015-03-01

    Full Text Available Specialeskrivere møder læringsudfordringer i skriveprocessen. Hvilke læringsudfordringer, det er, og hvordan studerende og vejledere hånd-terer dem, er artiklens fokus. Empirien er videooptagede vejlednings-møder, hvor der er minimum to optagelser for hver vejleder og stude-rendes forløb. Det teoretiske afsæt er generiske læringsudfordringer i vejledningsprocesser, hvor læring opstår, når de studerende passerer en læringsudfordring. Vejledere kan bruge forståelsen af læringsudfor-dringer til at ”nudge”- plante en idé – som en måde at få studerende til at passere læringsudfordringerne.  MA students writing up their final theses encounter a variety of conceptual thresholds during the process. The focus of this article is the identification of different kinds of conceptual threshold, and how the students overcome these obstacles. Video recordings of student supervision meetings provide the data for the analysis. For each supervisor – supervisee at least two recordings are considered. We go on to discuss how supervisors can make use of a conceptual thresholds approach, and nudge students in ways that will help them move on more easily.

  4. Photodynamic therapy for basal cell carcinoma.

    Science.gov (United States)

    Fargnoli, Maria Concetta; Peris, Ketty

    2015-11-01

    Topical photodynamic therapy is an effective and safe noninvasive treatment for low-risk basal cell carcinoma, with the advantage of an excellent cosmetic outcome. Efficacy of photodynamic therapy in basal cell carcinoma is supported by substantial research and clinical trials. In this article, we review the procedure, indications and clinical evidences for the use of photodynamic therapy in the treatment of basal cell carcinoma.

  5. Modern basal insulin analogs: An incomplete story

    OpenAIRE

    Singh, Awadhesh Kumar; Gangopadhyay, Kalyan Kumar

    2014-01-01

    The currently available basal insulin does not completely mimic the endogenous insulin secretion. This has continued to promote the search for ideal basal insulin. The newer basal insulin have primarily focused on increasing the duration of action, reducing variability, and reducing the incidence of hypoglycemia, particularly nocturnal. However, the changing criteria of hypoglycemia within a short span of a few years along with the surprising introduction of major cardiac events as another ou...

  6. Functional neuroanatomy of the basal ganglia.

    Science.gov (United States)

    Lanciego, José L; Luquin, Natasha; Obeso, José A

    2012-12-01

    The "basal ganglia" refers to a group of subcortical nuclei responsible primarily for motor control, as well as other roles such as motor learning, executive functions and behaviors, and emotions. Proposed more than two decades ago, the classical basal ganglia model shows how information flows through the basal ganglia back to the cortex through two pathways with opposing effects for the proper execution of movement. Although much of the model has remained, the model has been modified and amplified with the emergence of new data. Furthermore, parallel circuits subserve the other functions of the basal ganglia engaging associative and limbic territories. Disruption of the basal ganglia network forms the basis for several movement disorders. This article provides a comprehensive account of basal ganglia functional anatomy and chemistry and the major pathophysiological changes underlying disorders of movement. We try to answer three key questions related to the basal ganglia, as follows: What are the basal ganglia? What are they made of? How do they work? Some insight on the canonical basal ganglia model is provided, together with a selection of paradoxes and some views over the horizon in the field.

  7. Efecto del genotipo sobre la regeneración in vitro de Stevia rebaudiana a través de embriogénesis somática

    Directory of Open Access Journals (Sweden)

    Esther Julia Naranjo

    2016-01-01

    Full Text Available Stevia rebaudiana (Asteraceae, es una planta de gran importancia económica debido a sus propiedades medicinales y a la presencia de compuestos endulzantes en sus hojas, los cuales pueden sustituir la sacarosa en gran variedad de productos utilizados por personas con problemas de diabetes y obesidad. Con el propósito de estandarizar un método de propagación eficiente y efectivo para diferentes genotipos de Stevia cultivados en Colombia, en la presente investigación se evaluó el efecto sobre la inducción y desarrollo de embriones somáticos de diferentes combinaciones de los reguladores de crecimiento vegetal 2,4-D, IAA, IBA, 2iP y Zeatina, además de los suplementos adenina y agua de coco en el medio de cultivo basal Murashige y Skoog (1962, adicionado con glutamina. Con la combinación 2,4-D (18.09 µM y 2iP (7.38 µM se obtuvo el mayor número embriones somáticos por explante con características bien definidas. El genotipo tuvo un efecto significativo en la repuesta embriogénica, en el genotipo "SRQ-93" se logró la formación y el desarrollo de embriones somáticos, mientras que en los genotipos "Bertoni" y "Morita II", solo se obtuvo callo embriogénico y no embriogénico respectivamente. La conversión a plántulas se alcanzó en el medio de regeneración conteniendo GA3 (0.29 µM y carbón activado.

  8. Emma Bentz: I stadens skugga. Den medeltida landsbygden som arkeologiskt forskningsfält

    DEFF Research Database (Denmark)

    Kristiansen, Mette Svart

    2009-01-01

    Anmeldelse af doktordisputats, Lunds Universitet. Afhandlingen omhandler etableringen af den middelalderlige landbebyggelse som arkæologisk forskningsfelt fra 1930érne til i dag samt etableringen og vedligeholdelsen af et forskningsfelt indenfor den humanistiske videnskab....

  9. Fusarium basal rot in the Netherlands

    NARCIS (Netherlands)

    Visser, de C.L.M.; Broek, van den R.C.F.M.; Brink, van den L.

    2006-01-01

    Fusarium basal rot of onion, caused by Fusarium oxysporum f.sp. cepae, is a steadily increasing problem in The Netherlands. Financial losses for Dutch farmers confronted with Fusarium basal rot is substantial, due to yield reduction and high storage costs. This paper describes the development and

  10. The future of basal insulin supplementation

    NARCIS (Netherlands)

    Simon, Airin C. R.; DeVries, J. Hans

    2011-01-01

    This review presents an overview of the candidates for an improved basal insulin in the pharmaceutical pipeline. The first new basal insulin to enter the market is most likely insulin degludec (IDeg), currently reporting in phase 3 of development, from Novo Nordisk (Bagsvaerd, Denmark). IDeg has a

  11. Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome).

    Science.gov (United States)

    Bresler, Scott C; Padwa, Bonnie L; Granter, Scott R

    2016-06-01

    Nevoid basal cell carcinoma syndrome, or basal cell nevus syndrome (Gorlin syndrome), is a rare autosomal dominantly inherited disorder that is characterized by development of basal cell carcinomas from a young age. Other distinguishing clinical features are seen in a majority of patients, and include keratocystic odontogenic tumors (formerly odontogenic keratocysts) as well as dyskeratotic palmar and plantar pitting. A range of skeletal and other developmental abnormalities are also often seen. The disorder is caused by defects in hedgehog signaling which result in constitutive pathway activity and tumor cell proliferation. As sporadic basal cell carcinomas also commonly harbor hedgehog pathway aberrations, therapeutic agents targeting key signaling constituents have been developed and tested against advanced sporadically occurring tumors or syndromic disease, leading in 2013 to FDA approval of the first hedgehog pathway-targeted small molecule, vismodegib. The elucidation of the molecular pathogenesis of nevoid basal cell carcinoma syndrome has resulted in further understanding of the most common human malignancy.

  12. Molecular characterization of charcoal to identify adsorbed SOM and assess the effectiveness of common SOM-removing pretreatments prior to radiocarbon dating

    NARCIS (Netherlands)

    Wagner, T.V.; Mouter, A.K.; Parsons, J.R.; Sevink, J.; van der Plicht, J.; Jansen, B.

    A significant part of our knowledge on Holocene landscape development and associated human history in northwestern Europe is based on radiocarbon dating of charcoal originating from podzols. However, these soils are characterized by leaching of soil organic matter (SOM) that may adsorb to older

  13. Metastatic Basal Cell Carcinoma Accompanying Gorlin Syndrome

    Directory of Open Access Journals (Sweden)

    Yeliz Bilir

    2014-01-01

    Full Text Available Gorlin-Goltz syndrome or basal cell nevus syndrome is an autosomal dominant syndrome characterized by skeletal anomalies, numerous cysts observed in the jaw, and multiple basal cell carcinoma of the skin, which may be accompanied by falx cerebri calcification. Basal cell carcinoma is the most commonly skin tumor with slow clinical course and low metastatic potential. Its concomitance with Gorlin syndrome, resulting from a mutation in a tumor suppressor gene, may substantially change morbidity and mortality. A 66-year-old male patient with a history of recurrent basal cell carcinoma was presented with exophthalmus in the left eye and the lesions localized in the left lateral orbita and left zygomatic area. His physical examination revealed hearing loss, gapped teeth, highly arched palate, and frontal prominence. Left orbital mass, cystic masses at frontal and ethmoidal sinuses, and multiple pulmonary nodules were detected at CT scans. Basal cell carcinoma was diagnosed from biopsy of ethmoid sinus. Based on the clinical and typical radiological characteristics (falx cerebri calcification, bifid costa, and odontogenic cysts, the patient was diagnosed with metastatic skin basal cell carcinoma accompanied by Gorlin syndrome. Our case is a basal cell carcinoma with aggressive course accompanying a rarely seen syndrome.

  14. [Study on mechanism of SOM stabilization of paddy soils under long-term fertilizations].

    Science.gov (United States)

    Luo, Lu; Zhou, Ping; Tong, Cheng-Li; Shi, Hui; Wu, Jin-Shui; Huang, Tie-Ping

    2013-02-01

    Fourier transform infrared spectroscopy (FTIR) was applied to study the structure of soil organic matter (SOM) of paddy soils under long-term different fertilization treatments. The aim was to clarify the different distribution of SOM between different fertilization methods and between topsoil and subsoil, and to explore the stability mechanism of SOM under different fertilization treatments. The results showed that the content of topsoil organic carbon (SOC) was the highest under organic-inorganic fertilizations, with the increment of SOC by 18.5%, 12.9% and 18.4% under high organic manure (HOM), low organic manure (LOM) and straw returning (STW) respectively compared with no fertilization treatment (CK). The long-term fertilizations also changed the chemical structure of SOM. As compared with CK, different fertilization treatments increased the functional group absorbing intensity of chemical resistance compounds (aliphatic, aromaticity), carbohydrate and organo-silicon compounds, which was the most distinctive under treatments of HOM, LOM and STW. For example, the absorbing intensity of alkyl was 0.30, 0.25 and 0.29 under HOM, LOM and STW, respectively. These values were increased by 87% , 56% and 81% as compared with that under CK treatment. The functional group absorbing intensity of SOM in the topsoil was stronger than that in the subsoil, with the most distinctive difference under HOM, LOM and STW treatments. The present research indicated that the enhanced chemical resistance of functional group of SOM may contribute to the high contents of SOC in the paddy soils under long-term organic-inorganic fertilizations, which also suggested a chemical stabilization mechanism of SOM in the paddy soils.

  15. Neglected Giant Scalp Basal Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Anne Kristine Larsen, MD

    2014-03-01

    Full Text Available Summary: Rarely, basal cell carcinoma grows to a giant size, invading the underlying deep tissue and complicating the treatment and reconstruction modalities. A giant basal cell carcinoma on the scalp is in some cases treated with a combination of surgery and radiation therapy, resulting in local control, a satisfactory long-term cosmetic and functional result. We present a case with a neglected basal cell scalp carcinoma, treated with wide excision and postoperative radiotherapy, reconstructed with a free latissimus dorsi flap. The cosmetic result is acceptable and there is no sign of recurrence 1 year postoperatively.

  16. Basal encephalocele and morning glory syndrome.

    Science.gov (United States)

    Caprioli, J; Lesser, R L

    1983-01-01

    Basal encephaloceles are often associated with other midline anomalies such as hypertelorism, broad nasal root, cleft lip, and cleft palate. Optic disc anomalies such as pallor, dysplasia, optic pit, coLoboma, and megalopapilla have been reported to occur in patients with basal encephalocele We report a case of a child with a sphenoethmoidal encephalocele and morning glory syndrome of the optic nerve. The presence of such optic nerve anomalies with facial midline anomalies should alert the clinician to the possible presence of a basal encephalocele. Images PMID:6849854

  17. O corpo no teatro de animação: contribuições da educação somática na formação do ator

    OpenAIRE

    Coelho, Marcelle Teixeira

    2011-01-01

    Esse estudo aborda possíveis contribuições da Educação Somática no trabalho corporal do ator no Teatro de Animação. A pesquisa baseou-se na prática pedagógica desenvolvida por Jo Lacrosse e Claire Heggen, professores da École Supérieure Nationale des Arts de la Marionnette, em Charleville- Mézières, França. Ambos os professores utilizam três abordagens somáticas Método Feldenkrais, Eutonia e Técnica de Alexander como suporte para o trabalho corporal do ator animador. As teorias desenvolvida...

  18. Patologia de neonatos bovinos originados por meio da técnica de transferência nuclear de células somáticas: clonagem

    Directory of Open Access Journals (Sweden)

    Caio Rodrigues dos Santos

    2010-12-01

    Full Text Available Os mecanismos de morte em animais clonados a partir de células somáticas são poucos elucidados. Malformações de órgãos, alterações de tamanho e peso desses animais foram anomalias já descritas, porém em casos isolados. Desse modo, estudos nos níveis anatomo e histopatológicos são de suma importância para ajudar a compreensão dos fatores responsáveis pelos altos índices de insucessos com a utilização da TNCS (transferência nuclear de células somáticas. Assim, o presente trabalho foi realizado com o objetivo de descrever, por meio de exames anatomopatológicos, as alterações presentes em um grupo de animais gerados por TNCS, que vieram a óbito entre 1 e 19 dias de vida. Esse experimento foi realizado entre os anos de 2004 e 2008 na fazenda Tambaú, cidade de Tambaú, Estado de São Paulo. No total foram gerados 21 animais da raça Nelore (Bos indicus, sendo que 11 vieram a óbito e dez apresentaram boa evolução clínica no período perinatal. Foram realizadas as necropsias dos animais e posterior análise histopatológica de tecidos alterados. Esse estudo mostrou alta prevalência de alterações cardiopulmonares, que provavelmente foram determinantes nos mecanismos de morte dos animais. Dentre essas alterações a hipertensão pulmonar e modificações hemodinâmicas diagnosticadas através do exame histopatológico foram as mais frequentes.

  19. Hvordan ser den ost ud, som De ikke ved, De vil elske om to år?

    DEFF Research Database (Denmark)

    Grunert, Klaus G.

    2006-01-01

    Kender de Deres "latente behov"? Det gør De selvfølgelig ikke. Det er jo definitionen af begrebet: Et latent behov er et behov, som man ikke ved, at man har, men som kommer til overfladen, når man møder det rigtige produkt, som opfylder netop dette behov. Latente behov vedrører derfor den ost, vi...

  20. Trichoepithelioma And Multiple Basal Cell Epithelioma

    Directory of Open Access Journals (Sweden)

    Dey S.K

    1996-01-01

    Full Text Available A combination of multiple trichoepithelioma and basal cell epithelioma is reported. Although malignant degeneration of trichoepithelioma is debated, clinical and histopathological studies, in our case, hint at that. The case is reported for its rarity.

  1. Safety evaluation and bacterial community of kung-som using PCR-DGGE technique

    Directory of Open Access Journals (Sweden)

    Sutanate Saelao

    2016-08-01

    Full Text Available This study evaluates the safety of kung-som which was distributed in local markets and using PCR-DGGE technique to identify microflora in kung-som. Lactic acid bacteria (LAB were found at counts of more than 7 log CFU g-1 in all samples and the total viable counts were about 5-8 log CFU g-1 . Bacillus cereus and yeasts were detected at around 2 log CFU g-1 and 5-6log CFU g-1, respectively. For DGGE analysis, LAB and coagulase negative staphylococci (CNS bacteria dominated over other microorganisms. The sequencing of the DNA bands from DGGE gels corresponding to kung-som samples showed the presence of LAB as the major microflora in the products, namely: Lactobacillus farciminis, Lactobacillus plantarum, Lactococcus garvieae, Tetragenococcus halophilus and Weissella thailandensis. In addition, Staphylococcus carnosus was detected in kung-som as minor microflora. These dominant strains would allow the development of defined starter cultures for improving the quality of kung-som.

  2. Om dass-sætninger som afficeret eller efficeret objekt

    DEFF Research Database (Denmark)

    Holsting, Alexandra

    2013-01-01

    Temaet for nærværende artikel er en diskussion af muligheden for at fastlægge en tysk dass-sætnings semantiske funktion som afficeret eller efficeret objekt , når den optræder i rollen som komplement for verber, der har såvel en afficerende som en efficerende betydningsvariant, hvorved dass......-sætningen i det første tilfælde betegner et forhold, matrixsætningens subjektsreferent reagerer på, og i det andet indholdet af en ytring, der fremsættes af matrixsætningens subjektsreferent. Jeg går i artiklen særligt ind i diskussionen om, hvorvidt dass-sætningens modus kan tjene som formel indikation på...... den semantiske funktion, dvs. om en dass-sætning i konjunktiv utvetydigt kan tilskrives en funktion som efficeret objekt for matrixsætningsverbet....

  3. On the Relationship between Variational Level Set-Based and SOM-Based Active Contours

    Science.gov (United States)

    Abdelsamea, Mohammed M.; Gnecco, Giorgio; Gaber, Mohamed Medhat; Elyan, Eyad

    2015-01-01

    Most Active Contour Models (ACMs) deal with the image segmentation problem as a functional optimization problem, as they work on dividing an image into several regions by optimizing a suitable functional. Among ACMs, variational level set methods have been used to build an active contour with the aim of modeling arbitrarily complex shapes. Moreover, they can handle also topological changes of the contours. Self-Organizing Maps (SOMs) have attracted the attention of many computer vision scientists, particularly in modeling an active contour based on the idea of utilizing the prototypes (weights) of a SOM to control the evolution of the contour. SOM-based models have been proposed in general with the aim of exploiting the specific ability of SOMs to learn the edge-map information via their topology preservation property and overcoming some drawbacks of other ACMs, such as trapping into local minima of the image energy functional to be minimized in such models. In this survey, we illustrate the main concepts of variational level set-based ACMs, SOM-based ACMs, and their relationship and review in a comprehensive fashion the development of their state-of-the-art models from a machine learning perspective, with a focus on their strengths and weaknesses. PMID:25960736

  4. Use of basal stimulation at anesthesiology department

    OpenAIRE

    MARKOVÁ, Alena

    2012-01-01

    The theme ?The Use of Basal Stimulation at the Anaesthesiology and Resuscitation Department? was chosen in order to map out the use of this nursing method by the nurses and the staff who I cooperate with. The theoretical part deals with the environment at the Anaesthesiology and Resuscitation Department where the basal stimulation is used and also with special characteristics of the nursing care. Further, it deals with monitoring patients, causes of consciousness defects occurrence and kinds ...

  5. Degludec insulin: A novel basal insulin

    OpenAIRE

    Kalra, Sanjay; Unnikrishnan, Ambika Gopalakrishnan; Baruah, Manash; Kalra, Bharti

    2011-01-01

    This paper reviews a novel insulin analogue, degludec, which has the potential to emerge as an ideal basal insulin. It reviews the limitations of existing basal insulin and analogues, and highlights the need for a newer molecule. The paper discusses the potential advantages of degludec, while reviewing its pharmacologic and clinical studies done so far. The paper assesses the potential role of insulin degludec and degludec plus in clinical diabetes practice.

  6. Germinoma originating in the basal ganglia

    International Nuclear Information System (INIS)

    Anno, Y.; Hori, T.; Watanabe, T.; Takenobu, A.; Takigawa, H.; Kishimoto, M.; Tanaka, J.

    1990-01-01

    About 5-10% of primary intracranial germ cell tumors arise in basal ganglia and thalamus, where CT studies have been made. MR of the tumors in the pineal region, and to our knowledge, from one tumor in the basal ganglia were similar. In the present case, MR produced confusion in confirming diagnosis, which may require additional evidence from the clinical course, tumor markers, and CT images. (orig.)

  7. Historiens Mening som et Kreativt Produkt - En Analyse av Camille Paglias "The Birth of the Western Eye"

    OpenAIRE

    Kyllingstad, Elisabeth

    2016-01-01

    Dette prosjektet er en metodisk tilnærming til Camille Paglias filosofiske historietekst ”The Birth of the Western Eye”. Sexual Personae – Art and Decadence from Nefertiti to Emily Dickinson (1991) er en revidert versjon av doktorgradsavhendlingen hennes, som hun forsvarte i 1974. Den forteller om det Paglia identifiserer som grunnleggende drivkrefter i det vestlige mennesket, og dets kunstneriske produksjon. På denne måten kan verket leses som en guide gjennom vestlig tenkning så vel som kun...

  8. Får - ett miljövänligt alternativ som ogräsbekämpning

    DEFF Research Database (Denmark)

    Jensen, Anne Mette Dahl; Sintorn, Kim

    2010-01-01

    Erfarenhetsutbyte omkring fårbete som ogräsbekämpning var bland annat på dagordningen då svenska och danska greenkeepers som helt eller delvis sköter sina banor pesticidfritt möttes på Furesö Golfklubb den 4 maj i år.......Erfarenhetsutbyte omkring fårbete som ogräsbekämpning var bland annat på dagordningen då svenska och danska greenkeepers som helt eller delvis sköter sina banor pesticidfritt möttes på Furesö Golfklubb den 4 maj i år....

  9. Applications of Self-Organising Map (SOM) for prioritisation of endemic zones of filariasis in Andhra Pradesh, India.

    Science.gov (United States)

    Murty, Upadhayula Suryanaryana; Rao, Mutheneni Srinivasa; Sriram, K; Rao, K Madhusudhan

    2011-01-01

    Entomological and epidemiological data of Lymphatic Filariasis (LF) was collected from 120 villages of four districts of Andhra Pradesh, India. Self-Organising Maps (SOMs), data-mining techniques, was used to classify and prioritise the endemic zones of filariasis. The results show that, SOMs classified all the villages into three major clusters by considering the data of Microfilaria (MF) rate, infection, infectivity rate and Per Man Hour (PMH). By considering the patterns of cluster, appropriate decision can be drawn for each parameter that is responsible for disease transmission of filariasis. Hence, SOM will certainly be a suitable tool for management of filariasis. The detailed application of SOM is discussed in this paper.

  10. Embriogênese somática do caquizeiro Somatic embryogenesis of japanese persimmon

    Directory of Open Access Journals (Sweden)

    Dayse Cristina de Carvalho

    2004-08-01

    Full Text Available O objetivo deste trabalho foi o estabelecimento de um protocolo para a embriogênese somática do caquizeiro. Como explantes, foram utilizados embriões zigóticos em diversos estádios de desenvolvimento, retirados de frutos coletados de plantas adultas a campo, a partir de quatro semanas após o pleno florescimento até 22 semanas. O meio básico para os experimentos foi o MS½NO3. O meio inicial de indução foi suplementado com 20µM de 2,4-D e 2µM de cinetina. Os calos escuros obtidos foram repicados para outro meio de indução, com concentrações 10 ou 20 µM de 2,4-D e 2 µM de cinetina. Os calos com massas pró-embriogênicas obtidos foram transferidos para meio de manutenção e multiplicação com 2 µM de cinetina e 2,4-D nas concentrações 2,5; 5,0 e 10 µM. As massas embriogênicas formadas foram transferidas para meio de maturação suplementado com 0,5 µM de AIB e as concentrações 5; 10 e 20 µM de 2-iP. Os embriões formados foram isolados em dois meios de conversão, sendo o primeiro com 5 µM de 2-iP, 5 µM de AG3 e 0,5 µM de AIB e o segundo com 0,5 µM de AG3 e BAP, nas concentrações 0; 0,25; 0,5 e 1,0 µM. Como resultados, obteve-se o padrão indireto de embriogênese somática a partir de embriões zigóticos maduros, com mais de 22 semanas de formação, quando cultivados em meio de cultura com 10 µM de 2,4-D combinado com 2 µM de cinetina. A manutenção e a multiplicação das culturas embriogênicas foram mais eficientes com 5 µM de 2,4-D, na qual os pró-embriões avançaram para o estádio globular. Na fase de maturação, as concentrações de 2-iP testadas atuaram promovendo os embriões globulares a estádios mais avançados da ontogenia como cordiforme, torpedo e cotiledonar. A suplementação do meio de cultura com 1 µM de BAP e 0,5 µM de AG3 gerou a formação de plantas mais desenvolvidas, com maior número e tamanho de folhas.The goal of this work was to develop a protocol for persimmon cloning

  11. Efeitos do ultra-som de baixa intensidade na veia auricular de coelhos Effects of low intensity ultrasound in the auricular vein of rabbits

    Directory of Open Access Journals (Sweden)

    Marcelo Araújo

    2003-01-01

    Full Text Available OBJETIVO: Estudar a ação do ultra-som na veia auricular de coelhos. MÉTODOS: Vinte coelhos foram divididos em dois grupos de dez animais diferindo com relação ao local da aplicação, do ultra-som, o modo e o intervalo de tempo para a análise histopatológica (3 e 7 dias. Os animais foram submetidos à aplicação de ultra-som contínuo e pulsado em dois segmentos venosos da orelha previamente determinados. Cada animal foi o seu próprio controle. Empregou-se a freqüência de 3MHz, intensidade de 3W/cm² nos ciclos pulsado e contínuo por 10 minutos, de forma estacionária. O grupo I foi submetido a eutanásia após 3 dias e o grupo II em 7 dias contemplando a fase aguda do processo inflamatório. Empregou-se o teste exato de Fisher e o teste de Mc Nemar para análise estatística. RESULTADOS: Obteve-se trombose venosa e aumento de linfócitos de forma significativa (p= 0,032 nos grupos tratados com o modo contínuo. O modo pulsado não provocou efeitos deletérios. Outros achados foram congestão, edema, hemorragia e lesão da parede vascular. CONCLUSÕES: O ultra-som pulsado não provoca qualquer alteração na parede vascular nas condições do experimento.O ultra-som contínuo induz a trombose venosa e aumento dos linfócitos de forma significativa.PURPOSE: The purpose of this experimental work was evaluate the effects of low intensity in the auricular vein of rabbits. METHODS: Twenty rabbits were divided in two groups of ten animals. The groups differed about the place where the continuous and pulsed ultrasound were applied and the period that the material was collected for the morphologic examination (3 and 7 days. Acoustic coupling gel was used on marginal ear vein, each animal underwent continuous and pulsed ultrasound treatment, in segments previously marked with indelible ink. Each animal provided its own control. Ultrasound was used in the frequency of 3MHz, intensity of 3W/cm² in the pulsed and continuous modes during 10min

  12. Fermi field and Dirac oscillator in a Som-Raychaudhuri space-time

    Science.gov (United States)

    de Montigny, Marc; Zare, Soroush; Hassanabadi, Hassan

    2018-05-01

    We investigate the relativistic dynamics of a Dirac field in the Som-Raychaudhuri space-time, which is described by a Gödel-type metric and a stationary cylindrical symmetric solution of Einstein field equations for a charged dust distribution in rigid rotation. In order to analyze the effect of various physical parameters of this space-time, we solve the Dirac equation in the Som-Raychaudhuri space-time and obtain the energy levels and eigenfunctions of the Dirac operator by using the Nikiforov-Uvarov method. We also examine the behaviour of the Dirac oscillator in the Som-Raychaudhuri space-time, in particular, the effect of its frequency and the vorticity parameter.

  13. Som fricativo sonoro /ℑ/: modificações vocais

    Directory of Open Access Journals (Sweden)

    Helena D'Avila

    2010-12-01

    Full Text Available OBJETIVO: verificar as modificações vocais após a utilização do fricativo sonoro /ž/, em dez mulheres sem alterações vocais/laríngeas. MÉTODOS: foram realizadas medidas acústicas, perceptivo-auditiva, eletroglotografia e auto-avaliação da voz pré e pós-produção da técnica. RESULTADOS: foram estatisticamente significantes: as sensações subjetivas positivas; a maior definição de harmônicos e de formantes, diminuição do ruído, e maior regularidade no traçado. CONCLUSÃO: a técnica promove estabilidade vocal, gerando menor esforço fonatório, maior conforto durante a produção vocal e maior projeção vocal no grupo estudado.

  14. Modelling bare fallow SOM dynamics on a Chernozem soil in Central Germany

    Science.gov (United States)

    Franko, Uwe; Merbach, Ines

    2017-04-01

    The level of our process understanding about carbon and nitrogen fluxes in soils becomes visible at extreme situations like bare fallow soils. The observed dynamics of soil organic carbon (SOC) and total nitrogen (TN) in the top soil on a 28 years old fallow experiment on Haplic Chernozem in Bad Lauchstädt (Germany) was modelled using the Candy Carbon Balance (CCB) model that in its standard version was previously validated with LTFE data from Central Europe and a tillage experiment in Austria. For this study we selected two treatments of the fallow experiment in Bad Lauchstädt where the soil was kept bare with mechanical or chemical treatments. For this extreme land use (no input of fresh organic matter) the CCB model was improved to include the SOC related change of soil physical parameters and a dynamic handling of the physically stabilized soil organic matter (SOM) pool. The results from observation and modelling reflected the increased SOM turnover due to soil tillage for carbon as well as nitrogen and thus confirmed the modelling approach for non-tillage in CCB. The added sub model for the dynamics of physically stabilized SOM was also verified. The long term stabilized SOM is very important on this site. The modelled size of the physically stabilized SOC pool was about 55% of total SOC and reduced only slowly during the nearly three decades but the implementation of this effect resulted in improved simulation results. Thus we conclude that scenarios that lead to bigger changes of SOM stocks require a modelling approach that acknowledges the interaction between SOM and soil physical properties.

  15. Computerized tomographic diagnosis of basal skull fracture

    International Nuclear Information System (INIS)

    Tanaka, Tokutaro; Shimoyama, Ichiro; Endoh, Mitsutoshi; Ninchoji, Toshiaki; Uemura, Kenichi.

    1984-01-01

    The diagnosis of basal skull fractures used to be difficult, particularly on the basis of routine skull roentgenography alone. We have now examined the diagnostic value of conventional computerized tomography in basal skull fractures. We studied 82 cases clinically diagnosed as basal skull fractures. We examined them based on at least one of the following computerized tomographic criteria for basal skull fractures: 1) fracture line(s), 2) intracranial air, 3) fluid in the paranasal sinuses, and 4) fluid in the middle ear, including the mastoid air cells. The signs of the fracture line and of the intracranial air are definite indications of basal skull fracture, but the signs of fluid in the paranasal sinuses and/or in the middle ear are not definite. When combined, however, with such other clinical signs as black eye, Battle's sign, CSF leakage, CSF findings, and profuse nasal or ear bleeding, the diagnosis is more reliable. Seventy cases (85.4%) in this series had basal skull fractures according to our computerized tomographic criteria. Among them , 26 cases (31.7%) were diagnosed with fracture lines, 17 cases (20.7%) with intracranial air, 16 cases (19.5%) with fluid in the paranasal sinuses, 10 cases (12.2%) with fluid in the middle ear, and one case (1.2%) with fluid in both. Twelve cases (14.6%) of the 82 cases clinically diagnosed as basal skull fractures could not have been diagnosed on our computerized tomographic criteria alone. We diagnosed them because of CSF leakage, CSF findings, surgical findings, etc. (author)

  16. Filosofisk terapi som træning til døden

    DEFF Research Database (Denmark)

    Dræby, Anders

    Den eksistentielfænomenologiske terapi deler den opfattelse med stoicismen, at filosofiens hovedopgave er at hjælpe mennesket med at finde vej i en problematisk verden. Oplægget udforsker desuden et overlap, som består i den indsigt, at terapeutisk udfrielse fra menneskelig lidelse til livsduelig......Den eksistentielfænomenologiske terapi deler den opfattelse med stoicismen, at filosofiens hovedopgave er at hjælpe mennesket med at finde vej i en problematisk verden. Oplægget udforsker desuden et overlap, som består i den indsigt, at terapeutisk udfrielse fra menneskelig lidelse til...

  17. Surhetsvariasjoner som følge av nedtapping av et regulert vann.

    OpenAIRE

    Selmer-Olsen, A. R.

    1981-01-01

    Det har vært utført analyser og lagringsforsøk med prøver av tørrlagt bunnmateriale fra Trevatn tatt våren 1976. Prøver tatt ute i terrenget om høsten etter en lang tørr sommer viste stort sett samme bilde som prøvene fra våren etter lagring i laboratoriet under aerobe betingelser. Tabell 2 viser hvordan pH og SO4-S varierer med Iagringsbetingelsene. Oksydasjonsprosessene som slikt materiale blir utsatt for ved lufttilgang over et lengre tidsrom kan resultere i utvasking av meget sure forbind...

  18. Djur som en del i omvårdnad : En litteraturstudie

    OpenAIRE

    Jirback, Fia; Olsson, Malin

    2011-01-01

    Bakgrund: Äldre på boende idag kan känna att de saknar sociala interaktioner med vårdpersonal, familj eller vänner. För att uppleva god livskvalitet krävs bland annat trygghet, sociala interaktioner och aktiviteter. Djur kan användas som behandlingsmetod i vården i form av Animal-Assisted Activity (AAA) och Animal-Assisted Therapy (AAT). Syfte: Syftet med litteraturstudien var att belysa sällskapsdjurs betydelse för äldres livskvalitet på äldreboende. Metod: Studien har genomförts som en allm...

  19. From poverty to power? Brasiliansk sosialpolitikk som soft power-ressurs

    OpenAIRE

    Flatjord, Inger-Marie

    2015-01-01

    Grunnet markant fattigdomsreduksjon det siste tiåret, har Brasil gått fra å være det klassiske eksemplet på et land med stor fattigdom og enorme sosiale forskjeller, til å innta en posisjon som foregangsland i den globale utviklingsdiskursen. Landets sosialpolitikk har høstet annerkjennelse fra både FN og Verdensbanken, og Brasil opplever en stor etterspørsel fra utviklingsland som vil lære av landets sosialpolitiske erfaringer. I lys av dette har jeg i denne oppgaven analysert hvordan landet...

  20. Specialet som glasloft – hvorfor får mandlige studerende bedre specialekarakterer?

    Directory of Open Access Journals (Sweden)

    Vibeke Lehmann Nielsen

    2012-03-01

    Full Text Available Selvom de mandlige universitetsstuderende ikke klarer sig bedre end kvinderne frem til specialet, får de gennemsnitligt bedre specialekarakterer. Artiklens analyser viser, at det hverken handler om specialevejlederens køn eller om typen af universitetsstudium. Mulige forklaringer, som det er værd for kommende forskning at forfølge, er dels generel diskrimination af kvindelige specialestuderende og dels de studerendes møde med specialet, hvor kønnenes livssituation og/eller deres reaktioner på rollen som specialestuderende kan være forskellige.

  1. A new design for SLAM front-end based on recursive SOM

    Science.gov (United States)

    Yang, Xuesi; Xia, Shengping

    2015-12-01

    Aiming at the graph optimization-based monocular SLAM, a novel design for the front-end in single camera SLAM is proposed, based on the recursive SOM. Pixel intensities are directly used to achieve image registration and motion estimation, which can save time compared with the current appearance-based frameworks, usually including feature extraction and matching. Once a key-frame is identified, a recursive SOM is used to actualize loop-closure detecting, resulting a more precise location. The experiment on a public dataset validates our method on a computer with a quicker and effective result.

  2. Bloqueios nervosos guiados por ultra-som Bloqueos nerviosos guiados por ultrasonido Ultrasound-guided nerve blocks

    Directory of Open Access Journals (Sweden)

    Pablo Escovedo Helayel

    2007-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: As técnicas de bloqueios nervosos guiados por ultra-som são baseadas na visualização direta das estruturas nervosas, da agulha de bloqueio e das estruturas anatômicas adjacentes. Desta maneira, é possível depositar a solução de anestésico local precisamente em torno dos nervos e acompanhar a sua dispersão em tempo real, obtendo-se, assim, um bloqueio mais eficaz, de menor latência, menor dependência de referências anatômicas, menor volume de solução anestésica e maior segurança. CONTEÚDO: O artigo revisa os aspectos relativos aos mecanismos físicos para formação de imagens, a anatomia ultra-sonográfica do neuroeixo e dos plexos braquial e lombossacral, os equipamentos e materiais empregados nos bloqueios, os ajustes do aparelho de ultra-som para melhorar as imagens, os planos de visualização das agulhas de bloqueio e as técnicas e o treinamento em bloqueios guiados por ultra-som. CONCLUSÕES: Os passos para se obter sucesso em anestesia regional incluem a identificação exata da posição dos nervos, a localização precisa da agulha, sem lesões nas estruturas adjacentes e, finalmente, a injeção cuidadosa de anestésico local junto aos nervos. Embora a neuroestimulação forneça grande auxílio na identificação dos nervos, esta não consegue, isoladamente, preencher todas essas exigências. Por isso, acredita-se que os bloqueios guiados por ultra-som serão a técnica de eleição para anestesia regional num futuro não muito distante.JUSTIFICATIVA Y OBJETIVOS: Las técnicas de bloqueos nerviosos guiados por ultrasonido se basan en la visualización directa de las estructuras nerviosas, de la aguja de bloqueo y de las estructuras anatómicas adyacentes. De esa manera, se puede depositar la solución de anestésico local precisamente en torno de los nervios y acompañar su dispersión en tiempo real, obteniéndose así, un bloqueo más eficaz, de menor latencia, menor dependencia de

  3. 'Black star': uma mutação somática natural da uva fina de mesa cv. Brasil

    Directory of Open Access Journals (Sweden)

    Sergio Ruffo Roberto

    2012-09-01

    Full Text Available A uva fina de mesa 'Black Star', originada de uma mutação somática da uva cv. Brasil em Marialva-PR, é descrita quanto às suas principais características físico-químicas e produtivas. Suas bagas, com sementes, apresentam formato elipsoide alongado com coloração vermelho-escura, tendendo ao preto durante a maturação plena. O ciclo, o desempenho produtivo e a suscetibilidade às doenças fúngicas assemelham-se aos da cv. Itália. Durante a maturação plena, apresenta teor médio de sólidos solúveis de 14ºBrix, 0,6% de ácido tartárico e índice de maturação de 21. Trata-se de nova cultivar de uva fina de mesa com potencial de cultivo no Brasil.

  4. Estudo da fonoforese de ciclofenaco dietilamonio em voluntarios sadios

    OpenAIRE

    Claudio Fusaro

    2006-01-01

    Resumo: O transporte transdérmico de substâncias com o ultra-som terapêutico, método denominado fonoforese, oferece muitas vantagens quando comparado as outras vias de administração de drogas. O objetivo deste estudo foi verificar a influência do ultra-som na absorção de diclofenaco dietilamônio (Cataflam Emulgel®, Novartis) após fonoforese em voluntários sadios. Doze voluntários sadios foram submetidos à aplicação tópica de Cataflam Emulgel® em uma área de 150cm2 na região do dorso. No grupo...

  5. Localized basal meningeal enhancement in tuberculous meningitis

    Energy Technology Data Exchange (ETDEWEB)

    Theron, Salomine; Andronikou, Savvas; Grobbelaar, Marie; Steyn, Freda; Mapukata, Ayanda; Plessis, Jaco du [University of Stellenbosch, Department of Radiology, Tygerberg Hospital, P.O. BOX 19063, Tygerberg (South Africa)

    2006-11-15

    Focal basal meningeal enhancement may produce a confusing CT picture in children with suspected tuberculous meningitis (TBM). To demonstrate the incidence, distribution and appearance of localized basal meningeal enhancement in children with TBM. CT scans of patients with definite (culture proven) and probable (CSF suggestive) TBM were retrospectively evaluated by two observers. Localized basal enhancement was documented as involving: unilateral cistern of the lateral fossa (CLF), unilateral sylvian fissure, unilateral CLF and sylvian fissure in combination, unilateral CLF and sylvian fissure with ipsi- or contralateral ambient cistern and isolated quadrigeminal plate cistern. The study included 130 patients with TBM (aged 2 months to 13 years 9 months). Focal basal enhancement was seen in 11 patients (8.5%). The sylvian fissure was involved most commonly, followed by the lateral fossa cistern. The ambient cistern was involved in three patients and the quadrigeminal plate cistern in one. Focal areas of enhancement corresponded to the areas of infarction in every patient. Focal basal meningeal enhancement is common (8.5%) in paediatric TBM. This must be kept in mind when evaluating CT scans in children presenting with focal neurological findings, seizures or meningism in communities where TBM is endemic. (orig.)

  6. Localized basal meningeal enhancement in tuberculous meningitis

    International Nuclear Information System (INIS)

    Theron, Salomine; Andronikou, Savvas; Grobbelaar, Marie; Steyn, Freda; Mapukata, Ayanda; Plessis, Jaco du

    2006-01-01

    Focal basal meningeal enhancement may produce a confusing CT picture in children with suspected tuberculous meningitis (TBM). To demonstrate the incidence, distribution and appearance of localized basal meningeal enhancement in children with TBM. CT scans of patients with definite (culture proven) and probable (CSF suggestive) TBM were retrospectively evaluated by two observers. Localized basal enhancement was documented as involving: unilateral cistern of the lateral fossa (CLF), unilateral sylvian fissure, unilateral CLF and sylvian fissure in combination, unilateral CLF and sylvian fissure with ipsi- or contralateral ambient cistern and isolated quadrigeminal plate cistern. The study included 130 patients with TBM (aged 2 months to 13 years 9 months). Focal basal enhancement was seen in 11 patients (8.5%). The sylvian fissure was involved most commonly, followed by the lateral fossa cistern. The ambient cistern was involved in three patients and the quadrigeminal plate cistern in one. Focal areas of enhancement corresponded to the areas of infarction in every patient. Focal basal meningeal enhancement is common (8.5%) in paediatric TBM. This must be kept in mind when evaluating CT scans in children presenting with focal neurological findings, seizures or meningism in communities where TBM is endemic. (orig.)

  7. A influência do afastamento por acidente de trabalho sobre a ocorrência de transtornos psíquicos e somáticos

    Directory of Open Access Journals (Sweden)

    Elizabethe Cristina Borsonello

    Full Text Available O presente estudo teve como objetivo verificar a associação entre o afastamento por acidente de trabalho e a ocorrência de ansiedade e de depressão, averiguando se houve desencadeamento de transtornos somáticos e/ou transtornos nas relações sociais dos indivíduos. Em todos os casos estudados, constatamos que houve aumento significativo de sintomas após o afastamento e que o retorno ao trabalho foi impossibilitado devido à persistência da patologia e ao desenvolvimento de outras manifestações. Assim, o afastamento pôde ser considerado um estímulo estressor, pois além de causar transtornos psíquicos provocou alterações orgânicas.

  8. Retalho em ilha de tubarão: uma técnica cirúrgica reconstrutiva de defeitos localizados na área nasal alar/perialar. Um procedimento simples Shark island pedicle flap for repairing of basal cell carcinoma localized in nasal ala-perialar region: a simple procedure

    Directory of Open Access Journals (Sweden)

    Marisa C André

    2011-08-01

    Full Text Available O Carcinoma Basocelular é a neoplasia cutânea mais frequente. Os autores descrevem uma técnica realizada unicamente num tempo operatório para correção de defeitos na asa do nariz após excisão tumoral. Esta técnica simples permite a correção cirúrgica de defeitos nesta localização possibilitando a reconstrução da anatomia local e a preservação das unidades cosméticas, sem a necessidade de enxertoBasal Cell Carcinoma is the most common skin cancer. We describe a single-staged technique for correction of nasal ala defect after the excision of a basal cell carcinoma. This technique allows correction of surgical defects of the ala rebuilding the original anatomy, maintaining cosmetic units, without need for a graft

  9. Infiltrationsanæstesi som postoperativ smertebehandling ved hoftenær femurfraktur - et igangværende studie

    DEFF Research Database (Denmark)

    Bech, Rune Dueholm

    2008-01-01

    pertrochantær femurfraktur og collum femoris fraktur inkluderes. 50 patienter indgår i hver af de to diagnose-grupper (to delstudier). Ved randomisering tildeles patienterne hhv. Ropivacain eller placebo (NaCl), der gives som 1 peroperativ og 6 postoperative bolusinstillationer via et kateter, som fjernes efter...

  10. Inducción de callos embriogénicos y formación de proembriones somáticos en Pterogyne nitens Tull "tipa colorada"

    Directory of Open Access Journals (Sweden)

    Maritza Vacca Molina

    2014-07-01

    Full Text Available Título en español: Inducción de callos embriogénicos y formación de proembriones somáticos en Pterogyne nitens Tull "tipa colorada" Título en ingles: Embriogenic calli induction and somatic proembryo  formation in Pterogyne nitens Tull Título corto: Callo embriogénico y  proembriones somáticos en Pterogyne nitens Tull Resumen: Pterogyne nitens es un árbol que crece en bosques húmedos del Norte de la Argentina. Por su calidad maderera la especie se utiliza en forestación, reforestación o enriquecimiento de bosques nativos. Una alternativa a los métodos convencionales de propagación son las técnicas de cultivo de tejidos vegetales mediante el uso de la embriogénesis somática. El objetivo del presente trabajo es inducir la formación de callos embriogénicos y la obtención de proembriones somáticos evaluando la influencia del tipo de explanto, tipo y concentración de reguladores de crecimiento y composición del medio basal. Para la inducción de callos embriogénicos se utilizan explantos  extraídos de hojas cotiledonares, foliolos, tallos y raíces de  plántulas de dos meses de edad. Se emplean tres medios de cultivos MSC, MS50 y MSMOD. Cada medio de cultivo se suplementa con 2,4-D ó ANA en distintas concentraciones. A los 45 días los explantos provenientes de hojas cotiledonares en los medios de MSC con 2,4-D en concentraciones de  67.87, 107.41, 113.12, 135.74 y 180.99 µM, se logra en mayor proporción la formación de masas callosas amarillas. Con 107.41 µM de 2,4-D en el medio MSC se observa la formación de estructuras proembrionarias. Los segmentos radiculares en todos los tratamientos evaluados, no desarrollan callos. Palabras clave: Tipa colorada, micropropagación, embriogénesis, forestales, leguminosa. Abstract: Pterogyne nitens is a tree that grows in wet forests of Northern Argentina. Due to its quality timber especies are used in afforestation, reforestation or enrichment of native forests. An

  11. "Vi har ikke noget at sige, men vi gør det så koncentreret som muligt"

    DEFF Research Database (Denmark)

    Hansen, Kamma Overgaard

    mellemposition mellem på den ene side Arthur C. Dantos udråbelse af postmodernismen som The End of Art og Fredric Jamesons kritiske udlægning af den postmoderne kunst som simulerende og hans begrædelse af en tabt autenticitet - og på den anden side Linda Hutcheons langt mere positive definering af det...... postmoderne som ironisk og parodisk og dermed nytænkende og metareflekterende. Herudfra karakteriserer jeg De Unge Vilde som ironikere ud fra Søren Kierkegaards karakteristisk af ironikeren som en mellemfase mellem det æstetiske og det etiske livsstadie. Videre argumenterer jeg for, at Dantos ’end of art...

  12. Changes in SOM composition and stability to microbial degradation over time in response to wood chip ash fertilisation

    DEFF Research Database (Denmark)

    Hansen, Mette; Saarsalmi, Anna; Peltre, Clement

    2016-01-01

    spectroscopy (FTIR-PAS) analysis of bulk soil samples. Ash fertilisation of forest soils affected SOM composition in the O-horizon, but not in the top 5 cm of the mineral soil. The pH and biodegradability of SOM were increased in the O-horizon. The changes in SOM composition consisted of enrichment of Fe...... in Denmark, where ash had been spread at different times. Changes in SOM biodegradability were estimated based on an incubation experiment, expressed as percentage of initial carbon. Changes in SOM composition were characterised using thermal analysis and Fourier transform mid-infrared photoacoustic......- and Al-oxides/hydroxides, depletion of carboxylic and aromatic groups and lower thermal stability in soils with older and greater ash application. Ash fertilisation increased soil pH, either right after ash application or through a buffering effect of the ash on acidification caused by decomposing...

  13. Radiologic study of basal cell nevus syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Park, Tae Won [Dept. of Oral Radiology, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    1988-11-15

    Several cases of jaw cyst-basal cell nevus-bifid rib syndrome are presented. This syndrome consists principally of multiple jaw cysts, basal cell nevi, and bifid ribs but no one component is present in all patients. The purpose of this paper is to review the multiple characteristics of this syndrome and present three cases in a family and additional 4 cases. The many malformations associated with the syndrome have variable expressively. In the cases, multiple jaw cysts, pal mar and plantar pittings, bridging of sella, temporoparietal bossing, hypertelorism, cleft palate, and dystopia canthoru m have been observed.

  14. Basal cell nevus syndrome: 2 case reports

    International Nuclear Information System (INIS)

    Kim, Jae Duk; Seo, Yo Seob; Kim, Jin Soo

    2008-01-01

    The basal cell nevus syndrome (BCNS) is an autosomal dominant disorder, characterized by basal cell carcinomas, odontogenic keratocysts and skeletal abnormalities. We experienced two cases that represented several characteristics of BCNS. Case 1: a thirty three year-old man visited CSU hospital. His radiographs showed four cystic lesions at both maxillary sinus and both mandibular angle, with bifid rib and ectopic calcification of falx cerebri. After marsupialization and enucleation, recurrent and newly developing tendency were found on his follow-up radiographs. Case 2: a seventeen year-old man had four large cystic lesions which were diagnosed as odontogenic keratocysts. He had craniofacial anomalies which included ectopic calcification and frontal bossing.

  15. Radiologic study of basal cell nevus syndrome

    International Nuclear Information System (INIS)

    Park, Tae Won

    1988-01-01

    Several cases of jaw cyst-basal cell nevus-bifid rib syndrome are presented. This syndrome consists principally of multiple jaw cysts, basal cell nevi, and bifid ribs but no one component is present in all patients. The purpose of this paper is to review the multiple characteristics of this syndrome and present three cases in a family and additional 4 cases. The many malformations associated with the syndrome have variable expressively. In the cases, multiple jaw cysts, pal mar and plantar pittings, bridging of sella, temporoparietal bossing, hypertelorism, cleft palate, and dystopia canthoru m have been observed.

  16. MRI of the basal ganglia calcification

    International Nuclear Information System (INIS)

    Maeda, Masayuki; Murata, Tetsuhito; Kimura, Hirohiko

    1992-01-01

    MR imaging was performed for 11 patients (9 in Down's syndrome and 2 in idiopathic intracerebral calcification) who showed calcifications in bilateral basal ganglia on CT. High signal intensity in the basal ganglia was found only in one patient with idiopathic intracerebral calcification on T1-weighted image. The calcified areas of all patients in Down's syndrome did not show high signal intensity on T1-weighted image. The exact reasons why MRI exhibits the different signal intensities in calcified tissue on T1-weighted image are unknown. Further clinical investigations will be needed. (author)

  17. Skrivehandlinger som redskab til klar faglig formidling på PharmaSchool

    DEFF Research Database (Denmark)

    Laursen, Katja Årosin

    2016-01-01

    Denne artikel beskriver et pilotprojekt fra 2013, som havde til formål at øge opmærksomheden på klar skriftlig faglig formidling hos undervisere og studerende i kurset Dynamisk Biokemi på PharmaSchool ved Københavns Universitet (KU). På baggrund af en grundig behovsafdækning udviklede en akademisk...

  18. Velfærdsteknologi og læringsteknologi med MOOC som eksempel

    DEFF Research Database (Denmark)

    Helms, Niels Henrik; Heilesen, Simon

    2015-01-01

    Kapitlet redegører for ‘Velfærdsteknologi’ i forhold til begrebet 'læringsteknologi’. Læringsteknologi bestemmes som velfærdsteknologi udfoldet inden for uddannelsessystemet. Ligesom velfærdsteknologi indføres læringsteknologi med multiple dagsordener, hvor hensigterne både er at tilskynde den læ...

  19. Kombineret laser Doppler flowmetri og spectrophotometri som metode til vurdering af mikrocirculation

    DEFF Research Database (Denmark)

    Berggren Olsen, Mette; Sørensen, Hanne Birke; Houlind, Kim Christian

    Kombineret laser Doppler flowmetri og spectrophotometri som metode til vurdering af mikrocirculation Berggren, MB, reservelæge, Karkirurgisk Afdeling, Kolding, mette.marie.berggren.olsen@slb.regionsyddanmark.dk; Houlind, K, lektor, afdelingslæge, Ph.d., Karkirurgisk afdeling, Kolding, kim...

  20. Det moderne projekt – og portfolioen som en af mange succesteknologier

    DEFF Research Database (Denmark)

    Helms, Niels Henrik

    2010-01-01

    I artiklen diskuteres portfolioen i lyset af den canadiske fi losof Taylors begreber om rationel selvkontrol og ekspressiv artikulering som forskellige udtryk for det moderne. En række pædagogiske succesteknologier problematiseres og afsluttende foreslås en kommunitarisk forståelse af det...

  1. Er internethandel kommet for at blive? Eller er det bare krisen som kradser?

    DEFF Research Database (Denmark)

    Ivang, Reimer

    2012-01-01

    I de seneste dage har Jyllandsposten sat fokus på, at omsætningen i den danske detailhandel falder, der fyres, der spares, og det bliver endnu værre i de kommende måneder og år. I artiklen udråbes finanskrisen, som den store skurk, men er det nu den fulde sandhed?...

  2. Arbejdsmiljøseminarer som en metode til at skabe motivation, ansvar og ejerskab til sikkerhedsarbejdet

    DEFF Research Database (Denmark)

    Pedersen, Louise

    2011-01-01

    arbejdsmiljøseminarer som en ny metode til på en meningsfuld måde systematisk at involvere mellemlederne og de ansatte i virksomhedernes sikkerhedsarbejde og dermed potentielt at fremme deres motivation, ansvar og ejerskab til dette. Arbejdsmiljøseminarer tager udgangspunkt i de ansattes faglige ekspertise og...

  3. Det retlige sprog som virkelighedsskabende - graviditetsvært kontra surrogatmoder

    DEFF Research Database (Denmark)

    Pedersen, Frank Høgholm

    2018-01-01

    I dag er det undtagelsen, at kvinden, der bærer graviditeten og føder barnet i et surrogati-arrangement, er genetisk relateret til barnet. I artiklen foreslås som en supplerende betegnelse til surrogatmoder derfor betegnelsen: graviditetsvært. Valget af en retlig betegnelse til beskrivelse af fak...

  4. Teamcoaching som kvalificering af Cooperative Learning på læreruddannelsen

    DEFF Research Database (Denmark)

    Madsen, Henrik

    2008-01-01

    Projektet tager med et systemisk udgangspunkt et blik på coachingens muligheder som kvalificerende redskab for de studerendes tilegnelse af teoretiske og praktiske færdigheder i udviklingen af Cooperative Learning. Der er et teoretisk udgangspunkt i Luhmann og Vygotsky ligesom forskellige stadier i...... udviklingen fra gruppe til team skildres....

  5. SINs and SOMs: Neural microcircuits for size tuning in the zebrafish and mouse visual pathway.

    Directory of Open Access Journals (Sweden)

    Alison J. Barker

    2013-05-01

    Full Text Available In many animals, a fast and reliable circuit for discriminating between predator-sized objects and edible (prey-sized objects is necessary for survival. How are receptive fields in visual brain areas organized to extract information about size? Recent studies from the zebrafish optic tectum and the mouse visual cortex suggest de novo shaping of receptive fields by subtypes of inhibitory neurons. Del Bene et al. (2010 describe a population of GABAergic neurons in the zebrafish optic tectum (Superficial Interneurons, SINs that are necessary for size filtering during prey capture. Adesnik et al. (2012 describe a somatostatin-expressing interneuron population (SOMs that confers surround suppression on layer II/III pyramidal cells in mouse V1. Strikingly both the SINs and the SOMs, display size-dependent response properties. Increasing visual stimulus size increases excitatory input to these neurons. Dampening SIN or SOM activity alters tuning of neighboring circuits such that they lose preference for small objects. Both results provide exciting evidence for mechanisms of size filtering in visual circuits. Here we review the roles of the SINs and the SOMs and speculate on the similarity of such spatial filters across species.

  6. SOM storage and pool distribution in forest soils along climatic and altitudinal gradients across Switzerland

    Science.gov (United States)

    Gosheva, Sia; Müller, Mirjam; Walthert, Lorenz; Zimmermann, Stephan; Niklaus, Pascal A.; González Domínguez, Beatriz R.; Abiven, Samuel; Hagedorn, Frank

    2016-04-01

    Soil organic matter (SOM) plays a key role for a number of soil and ecosystem functions. Yet our quantitative understanding of the main driving factors is uncertain. SOM consists of a continuum of compounds ranging from slightly altered plant residues, known as particulate OM (POM) to mineral-associated OM (mOM). POM is the most rapidly cycling and hence vulnerable fraction of SOM. Therefore, it might respond particularly sensitive to climate change. In grassland soils, SOM content as well as the contribution of POM was found to increase with increasing elevation, which suggests that climate exerts a major control on SOM stability and storage. Little is known, however, for forest soils where a substantial fraction of POM is stored in the organic layer. In our study based on 1000 soil profiles, we explore the controlling factors of SOM stocks and the distribution of POM in the organic layer as well as within mineral soils in forests across Switzerland. We hypothesize that (i) elevation and hence climate have rather negligible effects on carbon (C) stocks, but exert large effects on SOM quality (contribution of POM, SOM depth distribution, and C/N ratio); (ii) furthermore, we postulate to find an elevational effect on C stocks in the organic layer but not in the mineral soil. We examined SOM stocks in the organic layer and the mineral soil of 1000 soil profiles. Mineral soils (0-20cm) from a subset of 54 sites were separated into free light fraction and occluded light fraction, representing POM, while fine heavy fraction and coarse heavy fraction represented the mineral-associated OM. The sites, all located in Swiss forests, were distributed along a great elevational gradient ranging between 277 and 2207 m a.s.l., and spanning a gradient in mean annual temperatures (MAT) from 0.6 to 11.9 °C, and mean annual precipitation (MAP) from 704 to 2340 mm. Our results indicate that POM and C/N ratio are more closely related to elevation and climate compared to mOM. For C

  7. Proximity Interactions among Basal Body Components in Trypanosoma brucei Identify Novel Regulators of Basal Body Biogenesis and Inheritance

    Directory of Open Access Journals (Sweden)

    Hung Quang Dang

    2017-01-01

    Full Text Available The basal body shares similar architecture with centrioles in animals and is involved in nucleating flagellar axonemal microtubules in flagellated eukaryotes. The early-branching Trypanosoma brucei possesses a motile flagellum nucleated from the basal body that consists of a mature basal body and an adjacent pro-basal body. Little is known about the basal body proteome and its roles in basal body biogenesis and flagellar axoneme assembly in T. brucei. Here, we report the identification of 14 conserved centriole/basal body protein homologs and 25 trypanosome-specific basal body proteins. These proteins localize to distinct subdomains of the basal body, and several of them form a ring-like structure surrounding the basal body barrel. Functional characterization of representative basal body proteins revealed distinct roles in basal body duplication/separation and flagellar axoneme assembly. Overall, this work identified novel proteins required for basal body duplication and separation and uncovered new functions of conserved basal body proteins in basal body duplication and separation, highlighting an unusual mechanism of basal body biogenesis and inheritance in this early divergent eukaryote.

  8. Optical coherence tomography of basal cell carcinoma

    DEFF Research Database (Denmark)

    Yücel, D.; Themstrup, L.; Manfredi, Maddalena

    2016-01-01

    Background: Basal cell carcinoma (BCC) is the most prevalent malignancy in Caucasians. Optical coherence tomography (OCT) is a non-invasive optical imaging technology using the principle of interferometry. OCT has shown a great potential in diagnosing, monitoring, and follow-up of BCC. So far most...

  9. Neglected giant scalp Basal cell carcinoma

    DEFF Research Database (Denmark)

    Larsen, Anne Kristine; El-Charnoubi, Waseem-Asim Ghulam; Gehl, Julie

    2014-01-01

    control, a satisfactory long-term cosmetic and functional result. We present a case with a neglected basal cell scalp carcinoma, treated with wide excision and postoperative radiotherapy, reconstructed with a free latissimus dorsi flap. The cosmetic result is acceptable and there is no sign of recurrence...

  10. Basal Cell Carcinoma: 10 Years of Experience

    International Nuclear Information System (INIS)

    Cigna, E.; Tarallo, M.; Maruccia, M.; Sorvillo, V.; Pollastrini, A.; Scuderi, N.

    2011-01-01

    Introduction. Basal cell carcinoma (BCC) is a locally invasive malignant epidermal tumour. Incidence is increasing by 10% per year; incidence of metastases is minimal, but relapses are frequent (40%-50%). The complete excision of the BCC allows reduction of relapse. Materials and Methods. The study cohort consists of 1123 patients underwent surgery for basal cell carcinoma between 1999 and 2009. Patient and tumor characteristics recorded are: age; gender; localization (head and neck, trunk, and upper and lower extremities), tumor size, excisional margins adopted, and relapses. Results. The study considered a group of 1123 patients affected by basal cell carcinoma. Relapses occurred in 30 cases (2,67%), 27 out of 30 relapses occurred in noble areas, where peripheral margin was <3mm. Incompletely excised basal cell carcinoma occurred in 21 patients (1,87%) and were treated with an additional excision. Discussion. Although guidelines indicate 3mm peripheral margin of excision in BCC <2cm, in our experience, a margin of less than 5mm results in a high risk of incomplete excisions

  11. Induced resistance: an enhancement of basal resistance?

    NARCIS (Netherlands)

    Vos, M. de; Robben, C.; Pelt, J.A. van; Loon, L.C. van; Pieterse, C.M.J.

    2002-01-01

    Upon primary pathogen attack, plants activate resistance mechanisms at the site of infection. Besides this so-called basal resistance, plants have also the ability to enhance their defensive capacity against future pathogen attack. There are at least two types of biologically induced resistance.

  12. Parallel basal ganglia circuits for decision making.

    Science.gov (United States)

    Hikosaka, Okihide; Ghazizadeh, Ali; Griggs, Whitney; Amita, Hidetoshi

    2018-03-01

    The basal ganglia control body movements, mainly, based on their values. Critical for this mechanism is dopamine neurons, which sends unpredicted value signals, mainly, to the striatum. This mechanism enables animals to change their behaviors flexibly, eventually choosing a valuable behavior. However, this may not be the best behavior, because the flexible choice is focused on recent, and, therefore, limited, experiences (i.e., short-term memories). Our old and recent studies suggest that the basal ganglia contain separate circuits that process value signals in a completely different manner. They are insensitive to recent changes in value, yet gradually accumulate the value of each behavior (i.e., movement or object choice). These stable circuits eventually encode values of many behaviors and then retain the value signals for a long time (i.e., long-term memories). They are innervated by a separate group of dopamine neurons that retain value signals, even when no reward is predicted. Importantly, the stable circuits can control motor behaviors (e.g., hand or eye) quickly and precisely, which allows animals to automatically acquire valuable outcomes based on historical life experiences. These behaviors would be called 'skills', which are crucial for survival. The stable circuits are localized in the posterior part of the basal ganglia, separately from the flexible circuits located in the anterior part. To summarize, the flexible and stable circuits in the basal ganglia, working together but independently, enable animals (and humans) to reach valuable goals in various contexts.

  13. Basal cell carcinoma on the left cheek

    International Nuclear Information System (INIS)

    Jancar, B.

    2007-01-01

    A 91-year-old female patient was treated with irradiation for histologically confirmed basal cell carcinoma on the left cheek. The tumour, measuring 3 x 3 cm, with the depth of 2 cm, was extending up to the lower lid of the left eye. (author)

  14. Vulvar basal cell carcinoma, a rare location

    Directory of Open Access Journals (Sweden)

    Cornelia Nitipir

    2018-05-01

    Full Text Available Basal Cell Carcinoma is the most common human malignant neoplasm. Vulvar basal cell carcinoma is rare, accounting for less than 5% of all vulvar neoplasms. Vulvar basal cell carcinomas are usually diagnosed late because they are often asymptomatic and tend to grow at slow rates. They are usually diagnosed late because they are often asymptomatic. However, these tumours may appear in areas which are normally covered with ultraviolet light. We present the case of a 60 years old woman diagnosed with invasive breast cancer for which she underwent surgery followed by chemotherapy and radiotherapy. The patient presented to our department with an ulcerated vulvar lesion. On inspection, the tumour measured 3/2 cm and was located on the left labium majus. The biopsy confirmed the diagnosis of vulvar basal cell carcinoma and a wide local excision was performed with no relapse at one year. In conclusion, early detection of BCC’s is critical to allow complete surgical cure so any abnormality on the vulva should be biopsied. A wide safety margin of 1cm should be achieved when resecting the tumour and the physician should keep in mind that the BCC’s of the vulva has a high recurrence rate. Previous chemotherapy is not associated with this type of non-melanoma skin cancer.

  15. Neglected basal cell carcinoma on scalp

    Directory of Open Access Journals (Sweden)

    Sudip Sarkar

    2016-01-01

    Full Text Available Giant basal cell carcinoma (BCC is a very rare entity. Usually, they occur due to the negligence of the patient. Local or distant metastasis is present in most cases. Here, we present a case of giant BCC that clinically resembled squamous cell carcinoma and demonstrated no metastasis at presentation.

  16. Apico-basal polarity complex and cancer

    Indian Academy of Sciences (India)

    Loss of cell polarity is a hallmark for carcinoma, and its underlying molecular mechanism is beginning to emerge from studies on model organisms and cancer cell lines. Moreover, deregulated expression of apico-basal polarity complex components has been reported in human tumours. In this review, we provide an ...

  17. Immunosuppressive Environment in Basal Cell Carcinoma

    DEFF Research Database (Denmark)

    Omland, Silje Haukali; Nielsen, Patricia S; Gjerdrum, Lise M R

    2016-01-01

    Interaction between tumour survival tactics and anti-tumour immune response is a major determinant for cancer growth. Regulatory T cells (T-regs) contribute to tumour immune escape, but their role in basal cell carcinoma (BCC) is not understood. The fraction of T-regs among T cells was analysed b...

  18. Heterogeneity of limbal basal epithelial progenitor cells.

    Science.gov (United States)

    Hayashida, Yasutaka; Li, Wei; Chen, Ying-Ting; He, Hua; Chen, Szu-yu; Kheirkah, Ahmad; Zhu, Ying-Tien; Matsumoto, Yukihiro; Tseng, Scheffer C G

    2010-11-01

    Although corneal epithelial stem cells (SCs) are located at the limbus between the cornea and the conjunctiva, not all limbal basal epithelial cells are SCs. Using 2 dispase digestions to remove different amounts of limbal basal epithelial cells for cross-sections, flat mounts, and cytospin preparations, double immunostaining to pancytokeratins (PCK) and vimentin (Vim) identified 3 p63+ epithelial progenitors such as PCK-/Vim+, PCK/Vim, and PCK-/Vim+ and 1 p63+ mesenchymal cell, PCK-/Vim+. PCK-/Vim- progenitors had the smallest cell size were 10-20 times more enriched on collagen I-coated dishes in the 5-minute rapid adherent fraction that contained the highest percentage of p63+ cells but the lowest percentage of cytokeratin12+ cells, and gave rise to high Ki67 labeling and vivid clonal growth. In contrast, PCK+/Vim+ and PCK+/Vim- progenitors were found more in the slow-adherent fraction and yielded poor clonal growth. PCK/Vim progenitors and clusters of PCK-/Vim+ mesenchymal cells, which were neither melanocytes nor Langerhans cells, were located in the limbal basal region. Therefore, differential expression of PCK and Vim helps identify small PCK-/Vim- cells as the most likely candidate for SCs among a hierarchy of heterogeneous limbal basal progenitors, and their close association with PCK-/Vim+ presumed "niche" cells.

  19. Effect of variable soil texture, metal saturation of soil organic matter (SOM) and tree species composition on spatial distribution of SOM in forest soils in Poland.

    Science.gov (United States)

    Gruba, Piotr; Socha, Jarosław; Błońska, Ewa; Lasota, Jarosław

    2015-07-15

    In this study we investigated the effect of fine (ϕclay (FF) content in soils, site moisture, metal (Al and Fe) of soil organic matter (SOM) and forest species composition on the spatial distribution of carbon (C) pools in forest soils at the landscape scale. We established 275 plots in regular 200×200m grid in a forested area of 14.4km(2). Fieldwork included soil sampling of the organic horizon, mineral topsoil and subsoil down to 40cm deep. We analysed the vertical and horizontal distribution of soil organic carbon (SOC) stocks, as well as the quantity of physically separated fractions including the free light (fLF), occluded light (oLF) and mineral associated fractions (MAF) in the mineral topsoil (A, AE) horizons. Distribution of C in soils was predominantly affected by the variation in the FF content. In soils richer in the FF more SOC was accumulated in mineral horizons and less in the organic horizons. Accumulation of SOC in mineral soil was also positively affected by the degree of saturation of SOM with Al and Fe. The increasing share of beech influenced the distribution of C stock in soil profiles by reducing the depth of O horizon and increasing C stored in mineral soil. The content of FF was positively correlated with the content of C in MAF and fLF fractions. The content of oLF and MAF fractions was also positively influenced by a higher degree of metal saturation, particularly Al. Our results confirmed that Al plays an important role in the stabilization of SOM inside aggregates (CoLF) and as in CMAF fractions. We also found a significant, positive effect of beech on the CfLF and fir on the CoLF content. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Metastatic giant basal cell carcinoma: a case report.

    Science.gov (United States)

    Bellahammou, Khadija; Lakhdissi, Asmaa; Akkar, Othman; Rais, Fadoua; Naoual, Benhmidou; Elghissassi, Ibrahim; M'rabti, Hind; Errihani, Hassan

    2016-01-01

    Basal cell carcinoma is the most common skin cancer, characterised by a slow growing behavior, metastasis are extremely rare, and it occurs in less than 0, 1% of all cases. Giant basal cell carcinoma is a rare form of basal cell carcinoma, more aggressive and defined as a tumor measuring more than 5 cm at its largest diameter. Only 1% of all basal cell carcinoma develops to a giant basal cell carcinoma, resulting of patient's negligence. Giant basal cell carcinoma is associated with higher potential of metastasis and even death, compared to ordinary basal cell carcinoma. We report a case of giant basal cell carcinoma metastaticin lung occurring in a 79 years old male patient, with a fatal evolution after one course of systemic chemotherapy. Giant basal cell carcinoma is a very rare entity, early detection of these tumors could prevent metastasis occurrence and improve the prognosis of this malignancy.

  1. Atrophy of the basal ganglia as the initial diagnostic sign of germinoma in the basal ganglia

    Energy Technology Data Exchange (ETDEWEB)

    Okamoto, K.; Ishikawa, K.; Takahashi, N.; Furusawa, T.; Sakai, K. [Department of Radiology, Niigata University Faculty of Medicine (Japan); Ito, J.; Tokiguchi, S. [Department of Radiology, Niigata University Faculty of Dentistry (Japan); Morii, K. [Department of Neurosurgery, Niigata University Brain Research Institute (Japan); Yamada, M. [Department of Pathology, Niigata University Brain Research Institute (Japan)

    2002-05-01

    Germ-cell tumors of the central nervous system generally develop in the midline, but the tumors can also occur in the basal ganglia and/or thalamus. However, MR images have rarely been documented in the early stage of the tumor in these regions. We retrospectively reviewed MR images obtained on admission and approximately 3 years earlier in two patients with germinoma in the basal ganglia, and compared them with CT. In addition to hyperdensity on CT, both hyperintensity on T1-weighted images and a small hyperintense lesion on T2-weighted images were commonly seen in the basal ganglia. These findings may be early MRI signs of germinoma in this region, and the earliest and most characteristic diagnostic feature on MRI was atrophy of the basal ganglia, which was recognizable before development of hemiparesis. (orig.)

  2. [SOMS-2: translation into portuguese of the screening for Somatoform Disorders].

    Science.gov (United States)

    Fabião, Cristina; Costa E Silva, Carolina; Fleming, Manuela; Barbosa, António

    2008-01-01

    The diagnosis of Somatization Disorder (SD) requires the presence of somatic medically unexplained symptoms (MUS) which must be assessed so that organic diseases may be excluded. SOMS-2 is a self-report measure for SD that assesses medically unexplained symptoms by requiring participants to answer affirmatively and qualify any of the complaints as MUS, only if they have obtained from his doctor the opinion that the said complaint is not due to an organic disease. According to the authors, original SOMS-2 has a good internal consistency with Cronbach's a = .87 and a good correlation between selfratings and interview (r = .75). After obtaining the author's permission, translation from and into English has been made by experienced translators. The resulting questionnaire has been used on a small group of patients. Afterwards the items in which there were difficulties in understanding during the pretest were identified and experienced practitioners were asked for suggestions. The resulting version was answered by 123 primary health care patients (sample I). After some modifications of the SOMS-2, another group of 190 primary health care patients answered the questionnaire (sample II). Most patients, in the first sample, found it difficult to understand that, in order to answer affirmatively it was necessary to answer three questions: 1) is the symptom present? 2) has your doctor found no clear causes for the symptom? 3) does the symptom affect your well-being? The difficulties in understanding items 21 and 45 (pre-test) were confirmed. Items 11, 28 and 38 were more easily understood when worded differently. In sample I, less than 5% of positive answers were given to items 20, 21, 23, 40, 43, 45, and 51. Probably because of the low education level of the Portuguese population which this sample reflects, difficulties in carrying out the instructions given at the beginning made it advisable to modify the SOMS-2, so that the three implicit questions in each question of the

  3. Bysykler : perspektiver på bysykkelordninger som en del av en bærekraftig bytransport og urban identitet

    OpenAIRE

    Langfeldt, Tuva

    2011-01-01

    SAMMENDRAG - Byutviklingen er de senere årene preget av grønne visjoner og planlegging for levende og bærekraftige byer. Et viktig ledd i denne utviklingen er menneskelig bevegelse og mobilitet, og det ses flere og flere steder med nye øyne på hvordan mobiliteten i byen kan og bør være. Fokus på sykkel som framkomstmiddel har blitt stadig mer populært, i Europa som USA, og som et resultat av behov for en mer syklende og mindre bilkjørende befolkning er det dukket opp bysykkelordninger i bå...

  4. Learning Reward Uncertainty in the Basal Ganglia.

    Directory of Open Access Journals (Sweden)

    John G Mikhael

    2016-09-01

    Full Text Available Learning the reliability of different sources of rewards is critical for making optimal choices. However, despite the existence of detailed theory describing how the expected reward is learned in the basal ganglia, it is not known how reward uncertainty is estimated in these circuits. This paper presents a class of models that encode both the mean reward and the spread of the rewards, the former in the difference between the synaptic weights of D1 and D2 neurons, and the latter in their sum. In the models, the tendency to seek (or avoid options with variable reward can be controlled by increasing (or decreasing the tonic level of dopamine. The models are consistent with the physiology of and synaptic plasticity in the basal ganglia, they explain the effects of dopaminergic manipulations on choices involving risks, and they make multiple experimental predictions.

  5. Faktorer som förklarar miljövänligt beteende hos unga vuxna

    OpenAIRE

    Rikner, Amanda

    2009-01-01

    Människors miljörelaterade beteenden behöver förbättras. I studien undersöktes unga vuxna universitetsstuderandes syn på klimatproblematiken. En enkät delades ut som mätte miljövänligt beteende, ansvarskänsla, tillit till forskning, upplevelse av att kunna påverka och kunskap när det gäller klimatproblematiken. Deltagarna fick också beskriva anledningar som möjliggör eller förhindrar en förbättring av klimatproblematiken. Deltog gjorde 97 personer. Resultatet visade på signifikanta samband me...

  6. Tidlige brukere av alkohol – hvem er de? Kjennetegn ved ungdom som starter tidlig med alkohol

    Directory of Open Access Journals (Sweden)

    Anders Grimsmo

    2009-10-01

    Full Text Available  SAMMENDRAGDebutalder med alkoholrus er en sterk prediktor for senere alkoholbruk. I denne undersøkelsen har visammenliknet de som starter med alkohol tidlig og før det er kulturelt akseptert, med ungdommenesom begynner i konfirmasjonsalder og de som utsetter alkoholdebuten. Vi finner at gruppen sombegynner tidlig ikke bare bryter de lokale tradisjonene for alkoholkonsum, men er i opposisjon tilnormer og autoriteter generelt. Alkohol er et positivt symbol for gruppen og det å ruse seg et ritualesom gir mening i deres miljø. Hjemmet står i den sterkeste posisjonen til å kunne utsette ungdommensalkoholdebut. Vi skisserer hvilke implikasjoner dette bør ha for strategien i det forebyggende arbeidet.

  7. Faktorer som påverkar barndödligheten i Etiopien

    OpenAIRE

    Östman, Hanna

    2014-01-01

    Temat för detta examensarbete är barndödlighet i Etiopien. Syftet är att undersöka den höga småbarnsdödligheten, orsakad av diarré och malaria. Detta är ett beställningsarbete för organisationen PADet, som har ett samarbete med yrkeshögskolan Arcada. Med småbarn menas i denna studie, barn under fem år. Frågeställningarna för arbetet är, Vilka är de främsta orsakerna som påverkar småbarnsdödligheten vid diarré och malaria? Och Vad görs idag för att minska på småbarnsdödligheten vid diarré och ...

  8. Differences in SOM decomposition and temperature sensitivity among soil aggregate size classes in a temperate grasslands.

    Science.gov (United States)

    Wang, Qing; Wang, Dan; Wen, Xuefa; Yu, Guirui; He, Nianpeng; Wang, Rongfu

    2015-01-01

    The principle of enzyme kinetics suggests that the temperature sensitivity (Q10) of soil organic matter (SOM) decomposition is inversely related to organic carbon (C) quality, i.e., the C quality-temperature (CQT) hypothesis. We tested this hypothesis by performing laboratory incubation experiments with bulk soil, macroaggregates (MA, 250-2000 μm), microaggregates (MI, 53-250 μm), and mineral fractions (MF, temperature and aggregate size significantly affected on SOM decomposition, with notable interactive effects (Ptemperature in the following order: MA>MF>bulk soil >MI(P classes (P temperature is closely associated withsoil aggregation and highlights the complex responses of ecosystem C budgets to future warming scenarios.

  9. BIM som Informationsbärare in i Förvaltningen : En studie vid Forsmarks Kraftgrupp

    OpenAIRE

    Svens, Therése

    2013-01-01

    BIM, Building Information Modeling, börjar vinna mark inom byggbranschen i Sverige och är en vedertagen process i vart och vartannat byggprojekt. Forsmarks Kraftgrupp står inför både upprustningar av sina anläggningar och nyproduktion av bland annat kontor, verkstad och hotell. BIM framstår nu som en lukrativ metod för att dra ner på projektkostnaderna, men även för att få ytterligare ordning och struktur på den enorma mängd dokumentation som ackumulerat under de dryga trettio åren av drift. ...

  10. Adversary phase change detection using S.O.M. and text data

    International Nuclear Information System (INIS)

    Speed, Ann Elizabeth; Doser, Adele Beatrice; Warrender, Christina E.

    2010-01-01

    In this work, we developed a self-organizing map (SOM) technique for using web-based text analysis to forecast when a group is undergoing a phase change. By 'phase change', we mean that an organization has fundamentally shifted attitudes or behaviors. For instance, when ice melts into water, the characteristics of the substance change. A formerly peaceful group may suddenly adopt violence, or a violent organization may unexpectedly agree to a ceasefire. SOM techniques were used to analyze text obtained from organization postings on the world-wide web. Results suggest it may be possible to forecast phase changes, and determine if an example of writing can be attributed to a group of interest.

  11. Forskeres arbejde med oplevelser af børns tegninger som forskningsmetode

    DEFF Research Database (Denmark)

    Nielsen, Anne Maj

    2012-01-01

    , experiences, intentions and engagement that may be difficult to articulate verbally. Research can include children’s art and drawings to study phenomena such as children’s feelings, emotions, experiences, intentions and engagements. Transparency of the ways in which art and drawings in specific ways...... at gøre rede for hvordan forskerens sanselige og æstetiske oplevelser af børns tegninger kan gøres transparente ved at tegninger betragtes som ’æstetiske objekter’ som led i forskningsprocessen. In art and drawing children can visually express phenomena in their mind such as feelings, emotions...... contribute to knowledge is a challenge in research. The aim of this article is to describe and discuss how the construct ‘aesthetic object’ may offer researchers an approach to children’s art and drawings that can explicitly include the researcher’s sensory and aesthetic experiences as knowledge....

  12. Basal ganglia lesions in children and adults

    Energy Technology Data Exchange (ETDEWEB)

    Bekiesinska-Figatowska, Monika, E-mail: m.figatowska@mp.pl [Department of Diagnostic Imaging, Institute of Mother and Child, ul. Kasprzaka 17a, 01-211 Warsaw (Poland); Mierzewska, Hanna, E-mail: h.mierzewska@gmail.com [Department of Neurology of Children and Adolescents, Institute of Mother and Child, ul. Kasprzaka 17a, 01-211 Warsaw (Poland); Jurkiewicz, Elżbieta, E-mail: e-jurkiewicz@o2.pl [Department of Diagnostic Imaging, Children' s Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw (Poland)

    2013-05-15

    The term “basal ganglia” refers to caudate and lentiform nuclei, the latter composed of putamen and globus pallidus, substantia nigra and subthalamic nuclei and these deep gray matter structures belong to the extrapyramidal system. Many diseases may present as basal ganglia abnormalities. Magnetic resonance imaging (MRI) and computed tomography (CT) – to a lesser degree – allow for detection of basal ganglia injury. In many cases, MRI alone does not usually allow to establish diagnosis but together with the knowledge of age and circumstances of onset and clinical course of the disease is a powerful tool of differential diagnosis. The lesions may be unilateral: in Rassmussen encephalitis, diabetes with hemichorea/hemiballism and infarction or – more frequently – bilateral in many pathologic conditions. Restricted diffusion is attributable to infarction, acute hypoxic–ischemic injury, hypoglycemia, Leigh disease, encephalitis and CJD. Contrast enhancement may be seen in cases of infarction and encephalitis. T1-hyperintensity of the lesions is uncommon and may be observed unilaterally in case of hemichorea/hemiballism and bilaterally in acute asphyxia in term newborns, in hypoglycemia, NF1, Fahr disease and manganese intoxication. Decreased signal intensity on GRE/T2*-weighted images and/or SWI indicating iron, calcium or hemosiderin depositions is observed in panthotenate kinase-associated neurodegeneration, Parkinson variant of multiple system atrophy, Fahr disease (and other calcifications) as well as with the advancing age. There are a few papers in the literature reviewing basal ganglia lesions. The authors present a more detailed review with rich iconography from the own archive.

  13. Basal ganglia lesions in children and adults

    International Nuclear Information System (INIS)

    Bekiesinska-Figatowska, Monika; Mierzewska, Hanna; Jurkiewicz, Elżbieta

    2013-01-01

    The term “basal ganglia” refers to caudate and lentiform nuclei, the latter composed of putamen and globus pallidus, substantia nigra and subthalamic nuclei and these deep gray matter structures belong to the extrapyramidal system. Many diseases may present as basal ganglia abnormalities. Magnetic resonance imaging (MRI) and computed tomography (CT) – to a lesser degree – allow for detection of basal ganglia injury. In many cases, MRI alone does not usually allow to establish diagnosis but together with the knowledge of age and circumstances of onset and clinical course of the disease is a powerful tool of differential diagnosis. The lesions may be unilateral: in Rassmussen encephalitis, diabetes with hemichorea/hemiballism and infarction or – more frequently – bilateral in many pathologic conditions. Restricted diffusion is attributable to infarction, acute hypoxic–ischemic injury, hypoglycemia, Leigh disease, encephalitis and CJD. Contrast enhancement may be seen in cases of infarction and encephalitis. T1-hyperintensity of the lesions is uncommon and may be observed unilaterally in case of hemichorea/hemiballism and bilaterally in acute asphyxia in term newborns, in hypoglycemia, NF1, Fahr disease and manganese intoxication. Decreased signal intensity on GRE/T2*-weighted images and/or SWI indicating iron, calcium or hemosiderin depositions is observed in panthotenate kinase-associated neurodegeneration, Parkinson variant of multiple system atrophy, Fahr disease (and other calcifications) as well as with the advancing age. There are a few papers in the literature reviewing basal ganglia lesions. The authors present a more detailed review with rich iconography from the own archive

  14. Linear Basal Cell Carcinoma: A Case Report

    Directory of Open Access Journals (Sweden)

    Yuko Ichinokawa

    2011-07-01

    Full Text Available Basal cell carcinoma (BCC presents with diverse clinical features, and several morphologic and histologic variants of BCC have been reported [Sexton et al.: J Am Acad Dermatol 1990;23:1118–1126]. Linear BCC was first described as a new clinical subtype in 1985 by Lewis [Int J Dematol 1985;24:124–125]. Here, we present a case of linear BCC that we recently encountered in an elderly Japanese patient, and review other cases reported in Japan.

  15. Faults detection approach using PCA and SOM algorithm in PMSG-WT system

    Directory of Open Access Journals (Sweden)

    Mohamed Lamine FADDA

    2016-07-01

    Full Text Available In this paper, a new approach for faults detection in observable data system wind turbine - permanent magnet synchronous generator (WT-PMSG, the studying objective, illustrate the combination (SOM-PCA to build Multi-local-PCA models faults detection in system (WT-PMSG, the performance of the method suggested to faults detection in system data, finding good results in simulation experiment.

  16. Sorg som relation og emotion – konturerne af en kritik af den tiltagende patologisering af sorgen

    DEFF Research Database (Denmark)

    Jacobsen, Michael Hviid

    2017-01-01

    Vi oplever i disse år en stadig større interesse for sorgen som genstandsfelt for forskellige forskningsmæssige initiativer og satsninger samt en stadig mere intensiveret kamp for de ressourcer, der følger med denne udvikling. Selvom vi altid skal byde ny viden velkommen, så bør vi også være vars...

  17. Sundhed som tema på den pædagogiske dagsorden

    DEFF Research Database (Denmark)

    Pedersen, Ulla; Schulz, Anette

    2015-01-01

    Dagtilbud og skole fremhæves i de nationale mål for danskernes sundhed som vigtige indsatsmiljøer (Regeringen, 2014). I dette kapitel berøres indledningsvist dagtilbuddets og skolens sundhedsfremmende rolle. Herefter præsenteres en række cases, hvor to faktorer har været særligt afgørende for at ...

  18. Aktionslæring som metode til udvikling af inkluderende praksis

    DEFF Research Database (Denmark)

    Olsson, Janne; Maltzahn, Lene Nyboe

    2014-01-01

    Kapitlet handler om, hvordan genkendelige hverdagspraksisser i daginstitutioner i nogle tilfælde ekskluderer børn, mens andre praksisser understøtter, at børn kan tage del i fællesskaber. Med afsæt i en konkret case argumenteres der for, at aktionslæring som metode kan gøre det muligt for pædagog...

  19. Data splitting for artificial neural networks using SOM-based stratified sampling.

    Science.gov (United States)

    May, R J; Maier, H R; Dandy, G C

    2010-03-01

    Data splitting is an important consideration during artificial neural network (ANN) development where hold-out cross-validation is commonly employed to ensure generalization. Even for a moderate sample size, the sampling methodology used for data splitting can have a significant effect on the quality of the subsets used for training, testing and validating an ANN. Poor data splitting can result in inaccurate and highly variable model performance; however, the choice of sampling methodology is rarely given due consideration by ANN modellers. Increased confidence in the sampling is of paramount importance, since the hold-out sampling is generally performed only once during ANN development. This paper considers the variability in the quality of subsets that are obtained using different data splitting approaches. A novel approach to stratified sampling, based on Neyman sampling of the self-organizing map (SOM), is developed, with several guidelines identified for setting the SOM size and sample allocation in order to minimize the bias and variance in the datasets. Using an example ANN function approximation task, the SOM-based approach is evaluated in comparison to random sampling, DUPLEX, systematic stratified sampling, and trial-and-error sampling to minimize the statistical differences between data sets. Of these approaches, DUPLEX is found to provide benchmark performance with good model performance, with no variability. The results show that the SOM-based approach also reliably generates high-quality samples and can therefore be used with greater confidence than other approaches, especially in the case of non-uniform datasets, with the benefit of scalability to perform data splitting on large datasets. Copyright 2009 Elsevier Ltd. All rights reserved.

  20. Legalisering som lösning? Erfarenheter av holländsk eutanasipraxis

    NARCIS (Netherlands)

    Boer, Th.A.

    2002-01-01

    Fastän vi lever i ett Europa som växer samman, så fortsätter dock många gränser att bestå. Vissa skillnader förblir eller har i de förgångna årtiondena till och med blivit djupare. Dödshjälpsdebatterna i Holland och Skandinavien ger oss ett exempel. Två stater med till stor del lika kultur, men

  1. Bærme (DDGS) som proteinfoder til malkekøer

    DEFF Research Database (Denmark)

    Sehested, Jakob; Sørensen, Martin Tang; Weisbjerg, Martin Riis

    2015-01-01

    DDGS er et proteinrigt fodermiddel fra produktionen af bio-etanol baseret på korn og majs, og det forventes på markedet i stigende mængder. Kornbaseret DDGS kan være et godt proteinfoder som uden negativ effekt på mælkeproduktion eller -kvalitet kan indgå med 15 % af rationens tørstof og kan...

  2. Estudo do leite de éguas sadias ou portadoras de mastite subclínica, pelo teste de Whiteside, análise microbiológica e contagem de células somáticas

    Directory of Open Access Journals (Sweden)

    Nereu Carlos Prestes

    1999-01-01

    Full Text Available Com o objetivo de identificar a microbiota existente no leite de éguas normais ou portadoras de mastite subclínica, coletaram-se amostras (10 a 15 ml de leite de 38 animais, que foram examinadas pelo teste de Whiteside, após a homogeneização das amostras dos dois tetos de cada animal. Os resultados foram negativos. Os exames microbiológicos realizados em meios de ágar sangue bovino 10% e ágar MacConkey revelaram presença de bactérias do gênero Staphylococcus spp. e Streptococcus spp. A contagem de células somáticas de amostras individuais de cada teto revelou números superiores a 500.000 células/ml de leite em somente 9,3% das 73 amostras de leite examinadas. Os resultados sugerem a realização de novos estudos objetivando-se a padronização do número de células somáticas no leite de éguas.

  3. Som i et spejl - Hans Egede-receptionen gennem tre hundrede år

    DEFF Research Database (Denmark)

    Kjærgaard, Kathrine

    2008-01-01

    stor, og længe ville man ikke vide af Hans Egede, der - skønt født i Norge - opfattedes som dansk. Først efter 1945, hvor Norge i kølvandet på Danskehjælpen under Anden Verdenskrig omsider forsonede sig med Danmark, tog man atter Hans Egede til sig. Blandt større mindesmærker, som er blevet til siden...... 1945, kan nævnes Nicolai Schiølls ungdommelige statue af grønlandsmissionæren i det centrale Oslo (1965) og Axel Revolds monumentale udskmykning af kirken i Hans Egedes nordnorske fødeby Harstad (1958). I Danmark, hvor sorgen over tabet af Norge var stor, var man i årene efter 1814 meget...... tilbageholdende med at omklamre tidligere norske landsmænd som Hans Egede. Først hen mod slutningen af 1800-tallet begyndte forbeholdene at smelte et efter et. Den definitive omdefinering af den dansk-norske 1700-tals patriot til national dansk kirkefyrste kom med opstillingen 1913 af hans statue ved Marmorkirken...

  4. Spatial Heterogeneity of SOM Concentrations Associated with White-rot Versus Brown-rot Wood Decay.

    Science.gov (United States)

    Bai, Zhen; Ma, Qiang; Dai, Yucheng; Yuan, Haisheng; Ye, Ji; Yu, Wantai

    2017-10-23

    White- and brown-rot fungal decay via distinct pathways imparts characteristic molecular imprints on decomposing wood. However, the effect that a specific wood-rotting type of fungus has on proximal soil organic matter (SOM) accumulation remains unexplored. We investigated the potential influence of white- and brown-rot fungi-decayed Abies nephrolepis logs on forest SOM stocks (i.e., soil total carbon (C) and nitrogen (N)) and the concentrations of amino sugars (microbial necromass) at different depths and horizontal distances from decaying woody debris. The brown-rot fungal wood decay resulted in higher concentrations of soil C and N and a greater increase in microbial necromass (i.e., 1.3- to 1.7-fold greater) than the white-rot fungal wood decay. The white-rot sets were accompanied by significant differences in the proportions of the bacterial residue index (muramic acid%) with soil depth; however, the brown-rot-associated soils showed complementary shifts, primarily in fungal necromass, across horizontal distances. Soil C and N concentrations were significantly correlated with fungal rather than bacterial necromass in the brown-rot systems. Our findings confirmed that the brown-rot fungi-dominated degradation of lignocellulosic residues resulted in a greater SOM buildup than the white-rot fungi-dominated degradation.

  5. Reklamen som pastiche. Om Dansk Sygeplejeråds annoncekampagne efteråret 1986

    Directory of Open Access Journals (Sweden)

    Gunhild Agger

    1989-08-01

    Full Text Available Der er flere og flere medieproducenter, der anser modtagerne for at besidde en vis tekstuel intelligens. Fra detektivpasticher som Dick Spanner og Batman over den konstant genreparodierende "Moon- lighting" (De heldige helte til Poul og Nulles respektløse faktion "I sandhedens Tjeneste" leges der med betydningsdannelsen. Seerne/læserne indbydes til selv at spille ping-pong med billeder og tekst. Gunhild Agger analyserer her denne tendens, sådan som den kom- mer til udtryk inden for reklamen: Anker Jørgensen som James Bond, og kondomer til Prinsessen på Ærten! Mest indgående beskæftiger hun sig med Dansk Sygeplejeråds brug af myten om sygeplejersken i en annoncekampagne op mod overenskomstforhandlingerne i 1987. Gunhild Agger nøjes ikke med en indholdsanalyse af annoncerne, men beskriver hele kampagnen: Dansk Sygeplejeråds hensigter med frem- stødet, kampagnens lancering over for den tre-dobbelte målgruppe, læsernes formodede reception, og kampagnens politiske og holdnings- mæssige effekter.

  6. Djævelen som Guds advokat - Nietzsche, filosofien og Paulus

    DEFF Research Database (Denmark)

    Pallesen, Carsten

    2012-01-01

    Artiklen tegner et dobbeltportræt af Paulus og Nietzsche ud fra en række nyere diskussioner om Nietzsches syn på Paulus hos aktuelle Nietzscheforskere, men også med udblik til den Paulus-renæssance, som har fundet sted i filosofien. Med det sidste tænkes navnlig på den franske filosof Alain Badious...... tese om Paulus som universalismens tænker. Artiklen fremhæver, hvordan hermeneutiske, kommunikationsteoretiske og semiotiske tilgange i den nyere tyske forskning navnlig hos Werner Stegmaier har ændret synet på forholdet mellem Nietzsches ’tegn’ (Dionysos, Zarathustra, ’anti-krist’) over for Nietzsches...... retfærdiggørelse ved troen. Nietzsches forhold til kristendommen er ikke kun bestemt af negative vurderinger, men tillige af en ambivalent taknemmelighed, som når han i den sene fase af forfatterskabet på en gang identificerer sig med Dionysos og ’den korsfæstede’....

  7. Lyd som kommunikation. En tværfaglig forskningsoversigt og en dagsorden for medieforskningen

    Directory of Open Access Journals (Sweden)

    Klaus Bruhn Jensen

    2008-06-01

    Full Text Available Lyden har ikke noget videnskabeligt hjem – i modsætning til f.eks. faste og levende billeder, der traditionelt er blevet studeret af henholdsvis kunsthistorien og filmvidenskaben. Denne artikel giver en oversigt over de mange, meget forskellige slags forskning om lyd. Formålet er at stimulere og kvalificere mere medieforskning om lyd. Hovedvægten ligger på lyd som kommunikation i og omkring medierne – som en kilde til mening og en ressource i social og kulturel handling, snarere end på lyd i et teknisk eller akustisk perspektiv (se f.eks. Plomp, 2002. Første del af artiklen gennemgår forskellige humanistiske og samfundsvidenskabelige tilgange til lydens tre grundformer – tale, musik og soundscapes eller lydmiljøer. Det midterste afsnit diskuterer den tidligere forsknings relevans for forskellige slags medier; artiklen skelner her mellem tre grader af medier. Og artiklens sidste del samler de tværfaglige indsigter i en dagsorden for (meget mere medieforskning om lyd som kommunikation.

  8. Lyd som kommunikation. En tværfaglig forskningsoversigt og en dagsorden for medieforskningen

    Directory of Open Access Journals (Sweden)

    Klaus Bruhn Jensen

    2006-06-01

    Full Text Available Lyden har ikke noget videnskabeligt hjem – i modsætning til f.eks. faste og levende billeder, der traditionelt er blevet studeret af henholdsvis kunsthistorien og filmvidenskaben. Denne artikel giver en oversigt over de mange, meget forskellige slags forskning om lyd. Formålet er at stimulere og kvalificere mere medieforskning om lyd. Hovedvægten ligger på lyd som kommunikation i og omkring medierne – som en kilde til mening og en ressource i social og kulturel handling, snarere end på lyd i et teknisk eller akustisk perspektiv (se f.eks. Plomp, 2002. Første del af artiklen gennemgår forskellige humanistiske og samfundsvidenskabelige tilgange til lydens tre grundformer – tale, musik og soundscapes eller lydmiljøer. Det midterste afsnit diskuterer den tidligere forsknings relevans for forskellige slags medier; artiklen skelner her mellem tre grader af medier. Og artiklens sidste del samler de tværfaglige indsigter i en dagsorden for (meget mere medieforskning om lyd som kommunikation.

  9. Distinct roles of SOM and VIP interneurons during cortical Up states

    Directory of Open Access Journals (Sweden)

    Garrett T. Neske

    2016-07-01

    Full Text Available During cortical network activity, recurrent synaptic excitation among pyramidal neurons is approximately balanced by synaptic inhibition, which is provided by a vast diversity of inhibitory interneurons. The relative contributions of different interneuron subtypes to inhibitory tone during cortical network activity is not well understood. We previously showed that many of the major interneuron subtypes in mouse barrel cortex are highly active during Up states (Neske et al., 2015; while fast-spiking (FS, parvalbumin (PV-positive cells were the most active interneuron subtype, many non-fast-spiking (NFS, PV-negative interneurons were as active or more active than neighboring pyramidal cells. This suggests that the NFS cells could play a role in maintaining or modulating Up states. Here, using optogenetic techniques, we further dissected the functional roles during Up states of two major NFS, PV-negative interneuron subtypes: somatostatin (SOM-positive cells and vasoactive intestinal peptide (VIP-positive cells. We found that while pyramidal cell excitability during Up states significantly increased when SOM cells were optogenetically silenced, VIP cells did not influence pyramidal cell excitability either upon optogenetic silencing or activation. VIP cells failed to contribute to Up states despite their ability to inhibit SOM cells strongly. We suggest that the contribution of VIP cells to the excitability of pyramidal cells may vary with cortical state.

  10. Feature combination analysis in smart grid based using SOM for Sudan national grid

    Science.gov (United States)

    Bohari, Z. H.; Yusof, M. A. M.; Jali, M. H.; Sulaima, M. F.; Nasir, M. N. M.

    2015-12-01

    In the investigation of power grid security, the cascading failure in multicontingency situations has been a test because of its topological unpredictability and computational expense. Both system investigations and burden positioning routines have their limits. In this project, in view of sorting toward Self Organizing Maps (SOM), incorporated methodology consolidating spatial feature (distance)-based grouping with electrical attributes (load) to evaluate the vulnerability and cascading impact of various part sets in the force lattice. Utilizing the grouping result from SOM, sets of overwhelming stacked beginning victimized people to perform assault conspires and asses the consequent falling impact of their failures, and this SOM-based approach viably distinguishes the more powerless sets of substations than those from the conventional burden positioning and other bunching strategies. The robustness of power grids is a central topic in the design of the so called "smart grid". In this paper, to analyze the measures of importance of the nodes in a power grid under cascading failure. With these efforts, we can distinguish the most vulnerable nodes and protect them, improving the safety of the power grid. Also we can measure if a structure is proper for power grids.

  11. Avaliação histológica da pele após exposição à gel acrescido de hialuronidase associado ou não a ultra-som

    OpenAIRE

    Chorilli, Marlus; Zague, Vivian; Almeida Prado Ribeiro, María Cristina de; Ricci Leonardi, Gislaine; Mariani Pires de Campos, María Silvia; Ozores Polacow, María Luiza

    2007-01-01

    O objetivo deste trabalho foi verificar os efeitos na pele de suínos machos de gel (G) contendo hialuronidase (H) associado ou não ao ultra-som (US). Em diferentes áreas aplicou-se G; G+H; G+H+US e mesoterapia (M). Fragmentos de pele foram processados em parafina. Para evidenciar ácido hialurônico (AH) utilizou-se coloração com Alcian Blue (AB) e para morfometria coloração com Hematoxilina/Eosina. Observou-se que G+H e G+H+US não reduziu coloração pelo AB nem apresentou diferenças...

  12. CT brain demonstration of basal ganglion calcification in adult HIV ...

    African Journals Online (AJOL)

    brain barrier has been postulated. Calcification of the basal ganglia in encephalopathic HIV/AIDS children has been relatively well documented. Only two adult HIV cases with basal ganglion calcification (BGC) have been reported in the literature.

  13. Somatic embryogenesis and plant regeneration in elite clones of Theobroma cacao Embriogênese somática e regeneração in vitro de clones elite de Theobroma cacao

    Directory of Open Access Journals (Sweden)

    Thiago Édson Ribeiro da Silva

    2008-10-01

    Full Text Available The objective of this work was to evaluated a procedure for somatic embryogenesis and regeneration of cacao (Theobroma cacao L. elite clones. Petal explants from cacao clones TSH 565 and TSH 1188 were cultured on PCG and SCG-2 media, for calli growth. Somatic embryos were formed on the surface of embryogenic calli after transfer to embryo development (ED medium. Clone TSH 565 showed a higher embryogenic potential than TSH 1188. The best combination of carbon source for embryo induction in ED medium was genotype-specific. Embryogenic callus formations increased in micropore tape-sealed Petri dishes, irrespective of cacao genotype. Mature somatic embryos were successfully converted into plantlets.O objetivo deste trabalho foi avaliar um procedimento para embriogênese somática e regeneração de clones elite de cacau. Pétalas dos clones de cacau TSH 565 e TSH 1188 foram cultivadas em meios PCG e SCG-2 para o crescimento de calos. Embriões somáticos desenvolveram-se na superfície dos calos embriogênicos, após a transferência para o meio ED. O clone TSH 565 apresentou maior potencial embriogênico do que o TSH 1188. A melhor combinação de fonte de carbono quanto à indução de embriões em meio ED foi específica do genótipo. A formação de calos embriogênicos foi superior em placas de Petri seladas com fita hipoalergênica, independentemente do genótipo. Embriões maduros de ambos os genótipos foram convertidos em plântulas.

  14. Criopreservação e embriogênese somática de calos de Dimocarpus longan Cryopreservation and somatic embryogenesis of Dimocarpus longan calli

    Directory of Open Access Journals (Sweden)

    Kazumitsu Matsumoto

    2004-12-01

    Full Text Available Os objetivos deste trabalho foram avaliar os efeitos de crioprotetores na criopreservação e da sacarose na embriogênise somática de calos de Dimocarpus longan. Após degelo os calos foram cultivados em meio de multiplicação, e a massa da matéria fresca foi determinada. Para se obter os embriões somáticos, calos e massas pro-embriônicas foram transferidos para meio de cultura contendo diferentes concentrações de sacarose. Entre os crioprotetores, a mistura de 5% de glicerol + 5% de dimetilsulfóxido proporcionou a maior quantidade de massa fresca dos calos. O maior número de embriões foi obtido no meio de cultura com 50 g L-1 de sacarose. Os resultados mostram que calos de Dimocarpus longan podem ser criopreservados e plântulas podem ser obtidas.Cryoprotectors on cryopreservation and sucrose on somatic embryogenesis of Dimocarpus longan calli were evaluated. The post-thaw calli were cultivated on multiplication medium, and the obtained fresh matter mass was measured. In order to obtain somatic embryos, calli and pro-embryonic masses were transferred into culture medium containing different concentrations of sucrose. Among the cryoprotectors, the mixture of 5% glycerol + 5% dimethylsulfoxide provided the largest quantity of calli fresh matter. The highest number of embryos was obtained on the culture medium with 50 g L-1 sucrose. The results show that Dimocarpus longan calli can be cryopreserved and plantlets be obtained.

  15. Traumatic bilateral basal ganglia hematoma: A report of two cases

    OpenAIRE

    Bhargava, Pranshu; Grewal, Sarvpreet Singh; Gupta, Bharat; Jain, Vikas; Sobti, Harman

    2012-01-01

    Traumatic Basal ganglia hemorrhage is relatively uncommon. Bilateral basal ganglia hematoma after trauma is extremely rare and is limited to case reports. We report two cases of traumatic bilateral basal ganglia hemorrhage, and review the literature in brief. Both cases were managed conservatively.

  16. Basal Cell Ameloblastoma: A Rare Histological Variant of an ...

    African Journals Online (AJOL)

    Ameloblastomas are an inscrutable group of oral tumors. Basal cell ameloblastoma is a rare variant of ameloblastoma with very few cases reported until date. The tumor is composed of more primitive cells and has less conspicuous peripheral palisading. It shows remarkable similarity to basal cell carcinoma, basal cell ...

  17. Influência da contagem de células somáticas sobre os componentes do leite

    Directory of Open Access Journals (Sweden)

    Maike Taís Maziero Montanhini

    2013-06-01

    Full Text Available mastite é uma inflamação da glândula mamária caracterizada por alterações do tecido glandular, causando distúrbios funcionais no quarto mamário afetado. Por sua vez, estes distúrbios induzem a diminuição na produção do leite e alterações em sua composição centesimal, suas propriedades físico-químicas, bacteriológicas e sensoriais.O objetivo foi avaliar a influência da contagem de células somáticas (CCS sobre os componentes do leite. Foram avaliados os resultados de 156.465 amostras analisadas pelo laboratório da Associação Paranaense de Criadores de Bovinos da Raça Holandesa, durante o período de julho a setembro de 2012. Foram determinadas a CCS e os teores de proteína, gordura, lactose, sólidos totais, caseína e extrato seco desengordurado (ESD. A gordura apresentou maior coeficiente de variação, seguida pelos teores de caseína, proteína, sólidos totais, ESD e, finalmente, o componente que apresentou menor variação foi a lactose. Entre as amostras avaliadas, 47,4% apresentaram ao menos um resultado em desacordo com os limites estipulados pela legislação brasileira. Para a CCS, 21,8% das amostras apresentaram resultados acima do padrão. O teor de gordura apresentou correlação positiva com a CCS. Por outro lado, o teor lactose e o ESD apresentaram correlação negativa com a CCS. O teor de proteína total não sofreu influência da CCS, no entanto, a caseína apresentou correlação positiva com a CCS. A mastite afeta a qualidade do leite, uma vez que promove alterações significativas nos seus componentes, principalmente gordura, lactose e caseína.

  18. CLUSTER ANALYSIS UNTUK MEMPREDIKSI TALENTA PEMAIN BASKET MENGGUNAKAN JARINGAN SARAF TIRUAN SELF ORGANIZING MAPS (SOM

    Directory of Open Access Journals (Sweden)

    Gregorius Satia Budhi

    2008-01-01

    Full Text Available Basketball World has grown rapidly as the time goes on. This is signed by many competition and game all over the world. With the result there are many basketball players with their different playing characteristics. Demand for a coach or scout to look for or search great players to make a solid team as a coach requirement. With this application, a coach or scout will be helped in analyzing in decision making. This application uses Self Organizing Maps algorithm (SOM for Cluster Analysis. The real NBA player data is used for competitive learning or training process and real player data from Indonesian or Petra Christian University Basketball Players is used for testing process. The NBA Player data is prepared through cleaning process and then is transformed into a form that can be processed by SOM Algorithm. After that, the data is clustered with the SOM algorithm. The result of that clusters is displayed into a form that is easy to view and analyze. This result can be saved into a text file. By using the output / result of this application, that are the clusters of NBA player, the user can see the statistics of each cluster. With these cluster statistics coach or scout can predict the statistic and the position of a testing player who is in the same cluster. This information can give a support for the coach or scout to make a decision. Abstract in Bahasa Indonesia : Dunia bola basket telah berkembang dengan pesat seiring dengan berjalannya waktu. Hal ini ditandai dengan munculnya berbagai macam dan jenis kompetisi dan pertandingan baik dunia maupun dalam negeri. Sehingga makin banyak dilahirkannya pemain berbakat dengan berbagai karakteristik permainan yang berbeda. Tuntutan bagi seorang pelatih/pemandu bakat, untuk dapat melihat secara jeli dalam memenuhi kebutuhan tim untuk membentuk tim yang solid. Dengan dibuatnya aplikasi ini, maka akan membantu proses analisis dan pengambilan keputusan bagi pelatih maupun pemandu bakat Aplikasi ini

  19. Subpopulations of somatostatin-immunoreactive nonpyramidal neurons in the amygdala and adjacent external capsule project to the basal forebrain: evidence for the existence of GABAergic projection neurons in the cortical nuclei and basolateral nuclear complex

    Directory of Open Access Journals (Sweden)

    Alexander J. McDonald

    2012-07-01

    Full Text Available The hippocampus and amygdala are key structures of the limbic system whose connections include reciprocal interactions with the basal forebrain (BF. The hippocampus receives both cholinergic and GABAergic afferents from the medial septal area of the BF. Hippocampal projections back to the medial septal area arise from nonpyramidal GABAergic neurons that express somatostatin (SOM, calbindin (CB, and neuropeptide Y (NPY. Recent experiments in our lab have demonstrated that the basolateral amygdala, like the hippocampus, receives both cholinergic and GABAergic afferents from the BF. These projections arise from neurons in the substantia innominata and ventral pallidum. It remained to be determined, however, whether the amygdala has projections back to the BF that arise from GABAergic nonpyramidal neurons. This question was investigated in the present study by combining Fluorogold (FG retrograde tract tracing with immunohistochemistry for GABAergic nonpyramidal cell markers, including SOM, CB, NPY, parvalbumin, calretinin, and glutamic acid decarboxylase (GAD. FG injections into the basal forebrain produced a diffuse array of retrogradely labeled neurons in many nuclei of the amygdala. The great majority of amygdalar FG+ neurons did not express nonpyramidal cell markers. However, a subpopulation of nonpyramidal SOM+ neurons, termed long range nonpyramidal neurons (LRNP neurons, in the external capsule, basolateral amygdala, and cortical and medial amygdalar nuclei were FG+. About one-third of the SOM+ LRNP neurons were CB+ or NPY+, and one-half were GAD+. It remains to be determined if these inhibitory amygdalar projections to the BF, like those from the hippocampus, are important for regulating synchronous oscillations in the amygdalar-BF network.

  20. Lean i Norge : opplever norske bedrifter som er mer lean, større økning i kundetilfredshet enn de som er mindre lean?

    OpenAIRE

    Fagereng, Hanne Eline; Askevold, Elisabeth Cathrine

    2010-01-01

    Vi ønsker å måle i hvor stor grad norske bedrifter har implementert lean, og for å måle grad av lean har vi utviklet et rammeverk basert på lean teori. Hovedformålet med lean er å øke kundeverdi med minst mulig ressursbruk, anstrengelse, energi, utstyr, tid, plass, material og kapital (Womack, Roos and Jones 2007). Vi vil utforske om høyere grad av lean fører til mer tilfredse kunder enn de som har lavere grad av lean. Altså om hovedformålet med lean blir oppnådd hvis man implementerer lean i...

  1. Nonsurgical Treatment Options for Basal Cell Carcinoma

    International Nuclear Information System (INIS)

    Lien, M. H.; Sondak, V. K.; Sondak, V. K.

    2011-01-01

    Basal cell carcinoma (BCC) remains the most common form of non melanoma skin cancer (NMSC) in Caucasians, with perhaps as many as 2 million new cases expected to occur in the United States in 2010. Many treatment options, including surgical interventions and nonsurgical alternatives, have been utilized to treat BCC. In this paper, two non-surgical options, imiquimod therapy and photodynamic therapy (PDT), will be discussed. Both modalities have demonstrated acceptable disease control rates, cosmetically superior outcomes, and short-term cost-effectiveness. Further studies evaluating long-term cure rates and long-term cost effectiveness of imiquimod therapy and PDT are needed.

  2. The Basal Ganglia and Adaptive Motor Control

    Science.gov (United States)

    Graybiel, Ann M.; Aosaki, Toshihiko; Flaherty, Alice W.; Kimura, Minoru

    1994-09-01

    The basal ganglia are neural structures within the motor and cognitive control circuits in the mammalian forebrain and are interconnected with the neocortex by multiple loops. Dysfunction in these parallel loops caused by damage to the striatum results in major defects in voluntary movement, exemplified in Parkinson's disease and Huntington's disease. These parallel loops have a distributed modular architecture resembling local expert architectures of computational learning models. During sensorimotor learning, such distributed networks may be coordinated by widely spaced striatal interneurons that acquire response properties on the basis of experienced reward.

  3. Basal cell carcinoma after radiation therapy

    International Nuclear Information System (INIS)

    Shimbo, Keisuke; Terashi, Hiroto; Ishida, Yasuhisa; Tahara, Shinya; Osaki, Takeo; Nomura, Tadashi; Ejiri, Hirotaka

    2008-01-01

    We reported two cases of basal cell carcinoma (BCC) that developed after radiation therapy. A 50-year-old woman, who had received an unknown amount of radiation therapy for the treatment of intracranial germinoma at the age of 22, presented with several tumors around the radiation ulcer. All tumors showed BCC. A 33-year-old woman, who had received an unknown amount of radiation therapy on the head for the treatment of leukemia at the age of 2, presented with a black nodule within the area of irradiation. The tumor showed BCC. We discuss the occurrence of BCC after radiation therapy. (author)

  4. Mössbauer spectroscopy of Basal Ganglia

    International Nuclear Information System (INIS)

    Miglierini, Marcel; Lančok, Adriana; Kopáni, Martin; Boča, Roman

    2014-01-01

    Chemical states, structural arrangement, and magnetic features of iron deposits in biological tissue of Basal Ganglia are characterized. The methods of SQUID magnetometry and electron microscopy are employed. 57 Fe Mössbauer spectroscopy is used as a principal method of investigation. Though electron microscopy has unveiled robust crystals (1-3 μm in size) of iron oxides, they are not manifested in the corresponding 57 Fe Mössbauer spectra. The latter were acquired at 300 K and 4.2 K and resemble ferritin-like behavior

  5. Mössbauer spectroscopy of Basal Ganglia

    Energy Technology Data Exchange (ETDEWEB)

    Miglierini, Marcel, E-mail: marcel.miglierini@stuba.sk [Institute of Nuclear and Physical Engineering, Faculty of Electrical Engineering and Information Technology, Slovak University of Technology, Ilkovičova 3, 812 19 Bratislava, Slovakia and Regional Centre of Advanced Technologies and Materials (Czech Republic); Lančok, Adriana [Institute of Inorganic Chemistry AS CR, v. v. i., 250 68 Husinec-Řež 1001 (Czech Republic); Kopáni, Martin [Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08 Bratislava (Slovakia); Boča, Roman [Department of Chemistry, Faculty of Natural Sciences, University of SS. Cyril and Methodius, 917 01 Trnava (Slovakia)

    2014-10-27

    Chemical states, structural arrangement, and magnetic features of iron deposits in biological tissue of Basal Ganglia are characterized. The methods of SQUID magnetometry and electron microscopy are employed. {sup 57}Fe Mössbauer spectroscopy is used as a principal method of investigation. Though electron microscopy has unveiled robust crystals (1-3 μm in size) of iron oxides, they are not manifested in the corresponding {sup 57}Fe Mössbauer spectra. The latter were acquired at 300 K and 4.2 K and resemble ferritin-like behavior.

  6. Ulikhet som impuls for nye oppdagelser i dans: Å tøye både muskler og meninger gjennom mangfold i Danselaboratoriet

    Directory of Open Access Journals (Sweden)

    Tone Pernille Østern

    2014-12-01

    Full Text Available I denne artikkelen har forfatterne fokus på hvordan ulikhet mellom mennesker kan fungere som en impuls som bidrar til meningsskaping, nye oppdagelser og transformasjon i improvisasjon i dans. Artikkelen tar utgangspunkt i Østerns avhandling ”Meaning-making in the Dance Laboratory. Exploring dance improvisation with differently bodied dancers” (2009. I artikkelen vever forfatterne sammen sine ulike stemmer. Tone Pernille Østerns perspektiv er som initiativtaker og tidligere koreograf-dansepedagog i Danselaboratoriet, mens Elen Øyens perspektiv er som danser i den samme gruppen. Øyen er danser og rullestolbruker. Hovedkonklusjonen i artikkelen er at gjennom å forstå ulikhet som en verdi og impuls til å møtes og skape i improvisasjon i dans, så kan deltakerne i gruppen gjennomgå kraftfulle transformative endringsprosesser når det gjelder synet på ”den andre”. Dette har en betydning som går langt ut over det konkrete, kunstneriske undervisningsrommet. ”Den andre” forstås i artikkelen som en konstruksjon som både muliggjør adskillelse og utestenging fra et fellesskap, men også som en mulighet til å forstå at ”den andre” ikke nødvendigvis er, eller skal være, som meg.

  7. Soil Response to Natural Vegetation Dynamics During the Late Holocene in Minnesota, USA, and Implications for SOM Accumulation and Loss

    Science.gov (United States)

    Mason, J. A.; Kasmerchak, C. S.; Keita, H.; Gruley, K. E.

    2016-12-01

    We studied soil response to late Holocene shifts in the dynamic boundary between forest and grassland, in two contrasting landscapes of Minnesota, USA. On both the glaciated landscape of northwestern Minnesota and steep bedrock slopes of southeastern Minnesota, forest has replaced grassland in the late Holocene (after 4 ka in the NW, during at least the last few 100 yr in the SE). Two distinct soil morphologies coexist in essentially the same climate and parent materials, Mollisols with deep SOM accumulation under grassland and Alfisols with most SOM in thin A horizons under forest. Organic carbon stocks of the Mollisols we sampled (to 1 m depth) are at least 50% greater than those of the Alfisols; thus, replacement of grassland by forest involves substantial SOM loss. Ultimately, the transition from Alfisols to Mollisols can probably be explained by much lower proportions of belowground SOM addition, and possibly less bioturbation, under forest; however, the timescale of this change is of great interest. Mollisols and transitional soils occur under forest today near the 19th century location of the vegetation boundary in NW Minnesota, and in certain slope positions in SE Minnesota. Stable C isotope profiles within those soils record the transition from C4 or mixed C3/C4 vegetation (tallgrass prairie or savanna) to C3 forest vegetation. Combined with 14C dating these data demonstrate a substantial lag in loss of the Mollisol morphology—thick SOM-rich A horizons with highly stable aggregates—after forest occupation. In fact, these thick A horizons may persist even when C4 grass-derived SOM has largely been replaced by SOM added after forest occupation. We are exploring possible explanations for this persistence in NW Minnesota. In SE Minnesota, it is likely related to parent material rich in dolomite fragments, with stable aggregation and SOM accumulation favored by abundant Ca2+and Mg2+. This parent material effect results in localization of high SOM

  8. 40 år gamle kvinner som bruker hormonregimer – sunne utvalg eller risikogrupper?

    Directory of Open Access Journals (Sweden)

    Sidsel Graff-Iversen

    2009-11-01

    Full Text Available  SAMMENDRAGFormålet med denne artikkelen var å studere brukerne av kombinerte antikonsepsjonsmidler, regimer med progesteronalene og østrogensubstitusjon blant norske 40-åringer. Var det først og fremst lavrisikogrupper – friske ogrøykfrie kvinner – som brukte p-piller av kombinasjonstype, slik gjeldende anbefalinger råder til? Var progesteronbrukerneet utvalg av særlig helsebevisste kvinner? Hvor utbredt var bruken av østrogen i denne aldersgruppen?Var det tegn til at østrogenbrukerne er en “healthy selection”, slik utenlandske studier har vist?Materialet er fra 40-åringsundersøkelser i 11 norske fylker i tiden 1997-99. Resultatene viser at 3,5% avkvinnene brukte kombinerte antikonseptiva og at disse utgjorde et “sunt utvalg” med lave andeler røykere og godhelse. De 9,4% av kvinnene som brukte progesteron alene, skilte seg derimot lite fra premenopausale kvinner utenhormonbruk. De 2,4% av kvinnene som brukte østrogen, hadde mindre god helse, høyere andel røykere og lavereutdanningsnivå, sammenlignet med premenopausale kvinner. Men sammenligning innen gruppen av post- og perimenopausalekvinner viste ingen vesentlig forskjell mellom østrogenbrukerne og andre. Resultatet fra den førstekontrollerte studien av østrogen og hjertesykdom kom i 1998, men førte ikke til noen påviselig forskjell i seleksjonentil østrogenbruk fra 1997 til 1999.Konklusjonen er at kvinnene som brukte kombinerte antikonseptiva i 40-årsalderen var en “sunn seleksjon” itråd med det som blir anbefalt, mens de som brukte progesteron alene skilte seg lite ut fra kvinner som ikke bruktehormoner. Kvinner som brukte østrogen i denne unge alderen, sto fram som en helsemessig risikogruppe imaterialet som helhet, men skilte seg lite ut fra andre antatt post- eller perimenopausale kvinner i 40-årsalderen.Graff-Iversen, S. 40-year old female sex hormone users: healthy selections or risk groups? Results fromhealth surveys in 11 Norwegian

  9. Training for Defense? From Stochastic Traits to Synchrony in Giant Honey Bees (<em>Apis dorsataem>

    Directory of Open Access Journals (Sweden)

    Gerald Kastberger

    2012-08-01

    Full Text Available In Giant Honey Bees, abdomen flipping happens in a variety of contexts. It can be either synchronous or cascaded, such as in the collective defense traits of shimmering and rearing-up, or it can happen as single-agent behavior. Abdomen flipping is also involved in flickering behavior, which occurs regularly under quiescent colony state displaying singular or collective traits, with stochastic, and (semi- synchronized properties. It presumably acts via visual, mechanoceptive, and pheromonal pathways and its goals are still unknown. This study questions whether flickering is preliminary to shimmering which is subject of the <em>fs em>(flickering-shimmering-transition> hypothesis? We tested the respective prediction that trigger sites (<em>ts> at the nest surface (where shimmering waves had been generated show higher flickering activity than the alternative non-trigger sites (<em>nts>. We measured the flickering activity of <em>ts>- and <em>nts>-surface bees from two experimental nests, before and after the colony had been aroused by a dummy wasp. Arousal increased rate and intensity of the flickering activity of both <em>ts>- and <em>nts> cohorts (P < 0.05, whereby the flickering intensity of <em>ts>-bees were higher than that of <em>nts>-bees (P < 0.05. Under arousal, the colonies also increased the number of flickering-active <em>ts>- and <em>nts>-cohorts (P < 0.05. This provides evidence that cohorts which are specialist at launching shimmering waves are found across the quiescent nest zone. It also proves that arousal may reinforce the responsiveness of quiescent curtain bees for participating in shimmering, practically by recruiting additional trigger site bees for expanding repetition of rate and intensity of shimmering waves. This finding confirms the <em>fs-transition> hypothesis and constitutes evidence that flickering is part of a basal colony-intrinsic information system

  10. Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak.

    Science.gov (United States)

    Polymeropoulos, E T; Heldmaier, G; Frappell, P B; McAllan, B M; Withers, K W; Klingenspor, M; White, C R; Jastroch, M

    2012-01-07

    Metabolic rates of mammals presumably increased during the evolution of endothermy, but molecular and cellular mechanisms underlying basal metabolic rate (BMR) are still not understood. It has been established that mitochondrial basal proton leak contributes significantly to BMR. Comparative studies among a diversity of eutherian mammals showed that BMR correlates with body mass and proton leak. Here, we studied BMR and mitochondrial basal proton leak in liver of various marsupial species. Surprisingly, we found that the mitochondrial proton leak was greater in marsupials than in eutherians, although marsupials have lower BMRs. To verify our finding, we kept similar-sized individuals of a marsupial opossum (Monodelphis domestica) and a eutherian rodent (Mesocricetus auratus) species under identical conditions, and directly compared BMR and basal proton leak. We confirmed an approximately 40 per cent lower mass specific BMR in the opossum although its proton leak was significantly higher (approx. 60%). We demonstrate that the increase in BMR during eutherian evolution is not based on a general increase in the mitochondrial proton leak, although there is a similar allometric relationship of proton leak and BMR within mammalian groups. The difference in proton leak between endothermic groups may assist in elucidating distinct metabolic and habitat requirements that have evolved during mammalian divergence.

  11. Bearing performance degradation assessment based on time-frequency code features and SOM network

    International Nuclear Information System (INIS)

    Zhang, Yan; Tang, Baoping; Han, Yan; Deng, Lei

    2017-01-01

    Bearing performance degradation assessment and prognostics are extremely important in supporting maintenance decision and guaranteeing the system’s reliability. To achieve this goal, this paper proposes a novel feature extraction method for the degradation assessment and prognostics of bearings. Features of time-frequency codes (TFCs) are extracted from the time-frequency distribution using a hybrid procedure based on short-time Fourier transform (STFT) and non-negative matrix factorization (NMF) theory. An alternative way to design the health indicator is investigated by quantifying the similarity between feature vectors using a self-organizing map (SOM) network. On the basis of this idea, a new health indicator called time-frequency code quantification error (TFCQE) is proposed to assess the performance degradation of the bearing. This indicator is constructed based on the bearing real-time behavior and the SOM model that is previously trained with only the TFC vectors under the normal condition. Vibration signals collected from the bearing run-to-failure tests are used to validate the developed method. The comparison results demonstrate the superiority of the proposed TFCQE indicator over many other traditional features in terms of feature quality metrics, incipient degradation identification and achieving accurate prediction. Highlights • Time-frequency codes are extracted to reflect the signals’ characteristics. • SOM network served as a tool to quantify the similarity between feature vectors. • A new health indicator is proposed to demonstrate the whole stage of degradation development. • The method is useful for extracting the degradation features and detecting the incipient degradation. • The superiority of the proposed method is verified using experimental data. (paper)

  12. En teoretisk utdyping av rom og materialitet som pedagogisk ressurs i barnehagen

    Directory of Open Access Journals (Sweden)

    Solveig Nordtømme

    2015-07-01

    Full Text Available Abstract: This article is a theoretical exploration with the aim of discussing an ontological basis for space and materiality as educational resources in kindergarten. Attention is directed on children’s play experiences interacting with space and materiality, and how children use and create space. The metaphors front stage, space in between, and backstage (inspired from Erving Goffman, 1969, which form the study's main findings, are used as the backdrop for the issue and analyzes. The empirical material used in this exploration has been collected with an ethnographic methodological approach in two kindergartens. Maurice Merleau-Ponty’s (1962 focus on bodily experience and presence in space, along with concepts from Latour’s (2005 actor-network theory, is used to explore the data. The article contributes with theoretical tools for professionals in kindergarten teaching, to shed light on the importance of space, materiality and play in children's everyday life in kindergarten.Sammendrag: Denne artikkelen diskuterer et ontologisk grunnlag og er en teoretisk utforskning av rom og materialitet som en pedagogisk ressurs i barnehagen. Oppmerksomheten er rettet mot barns lekeerfaringer i samspill med rom og materialitet, og hvordan barn bruker og skaper rom. Metaforene hovedrom, mellomrom, og bakrom (inspirert fra Erving Goffman, 1969, som danner studiens hovedfunn, blir brukt som et bakteppe for problemstilling og analyser av det empiriske materialet fra to barnehager. Maurice Merleau-Ponty publikasjoner The Phenomenology of Perception (Merleau-Ponty, 1962 med sitt fokus på kroppslig erfaring i levd rom, blir brukt sammen med begreper fra Latours aktør-nettverksteori (Latour 2005 til å utforske hvordan rom og materialitet kan være pedagogiske ressurser. Artikkelens kunnskapsbidrag er å presentere et teoretisk verktøy for barnehageprofesjonen og kunnskaper om lekens betydning i barns hverdag i barnehagen.

  13. Palaeocene-early Eocene inversion of the Phuquoc-Kampot Som Basin

    DEFF Research Database (Denmark)

    Fyhn, Michael B. W.; Pedersen, Stig A.S.; Boldreel, Lars Ole

    2010-01-01

    /Pb analysis is used to unravel the basin history. This reveals a hitherto unknown earliest Palaeogene basin inversion associated with the Luconian suturing to SE Asia and the shutdown of palaeo-Pacific subduction underneath SE Asia. The Phuquoc–Kampot Som Basin and the Khorat Basin in Thailand constitute...... the erosional remnants of a larger basin that covered large parts of SE Asia in Late Mesozoic time, and subsequently became segregated during earliest Palaeogene inversion and erosion. Inversion was focused along the several hundred kilometres long Kampot and Khmer–Chanthaburi fold belts that confine...

  14. En bok for meg? Litteraturvalg med knyttneveprøven som metode.

    OpenAIRE

    Nyhus, Mari

    2016-01-01

    Sammendrag Denne masteroppgaven har følgende problemstilling: Kan elever gjennom en strukturert metode klare å finne egnet litteratur på biblioteket på egenhånd? Studien oppgaven bygger på har til hensikt å undersøke om elever klarer å finne seg egnet litteratur på skolebiblioteket på egenhånd. Forskning viser at elever som leser på egenhånd for å utvikle lesingen sin, trenger tekster på et umiddelbart lesenivå. Det vil si at elevene skal forstå og kunne avkode 94% av ordene de leser. (Frost ...

  15. Fatigue Level Estimation of Bill Based on Acoustic Signal Feature by Supervised SOM

    Science.gov (United States)

    Teranishi, Masaru; Omatu, Sigeru; Kosaka, Toshihisa

    Fatigued bills have harmful influence on daily operation of Automated Teller Machine(ATM). To make the fatigued bills classification more efficient, development of an automatic fatigued bill classification method is desired. We propose a new method to estimate bending rigidity of bill from acoustic signal feature of banking machines. The estimated bending rigidities are used as continuous fatigue level for classification of fatigued bill. By using the supervised Self-Organizing Map(supervised SOM), we estimate the bending rigidity from only the acoustic energy pattern effectively. The experimental result with real bill samples shows the effectiveness of the proposed method.

  16. Anatomia microcirúgica da substâcia perfurada anterior basal humana Microsurgical anatomy of the human basal anterior perforated substance

    Directory of Open Access Journals (Sweden)

    Arlindo Alfredo Silveira D’Ávila

    2006-06-01

    Full Text Available A substância perfurada anterior constitui referencial na base do encéfalo. Localizada acima da bifurcação subaracnóidea da artéria carótida interna em sua porção basal e junto à artéria comunicante anterior na face inter-hemisférica, é transfixada por ramos perfurantes dirigidos aos núcleos telencefálicos corticais, cápsula interna e parte do tálamo. Por injeção intravascular de gelatina carminada, resina de Batson e látex, analisamos 50 hemisférios cerebrais humanos adultos de ambos os sexos, sob o microscópio cirúrgico. Objetivamos contribuir para a determinação da origem, número e topografia dos ramos destinados a essa região, seu curso, anastomoses e territórios de penetração. Propusemo-nos também a analisar a contribuição da artéria comunicante anterior à substância perfurada anterior. Foram encontradas variações anatômicas, incluindo anastomoses, envolvendo principalmente a artéria cerebral média e a artéria coróidea anterior. Estes conhecimentos são de interesse clínico-cirúrgico em razão da freqüência de patologias vasculares e tumorais a ela relacionadas.The anterior perforated substance (APS is a landmark in the basal forebrain. It has a basal face located above the carotid bifurcation in the subarachnoid space, and an interhemispheric one. It is the site of passage of the arteries to the caudate nucleus, putamen, internal capsule, adjacent areas of the globus pallidus and thalamus. Fifty hemispheres from twenty-five adult cadavers were obtained. The arteries were perfused with colored latex, Batson’s resin and gelatin colored with carmine. Using a surgical microscope we have determined the origin, local and number of origin from the parent vessel. The sites of penetration in the mediolateral and anteroposterior direction were also recorded. The anterior communicating artery contribution to the basal APS was reviewed. Significant vascular variations and anastomoses were encountered

  17. Histologic Mimics of Basal Cell Carcinoma.

    Science.gov (United States)

    Stanoszek, Lauren M; Wang, Grace Y; Harms, Paul W

    2017-11-01

    - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. - To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. - Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. - In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.

  18. Estimating shrub biomass from basal stem diameters

    Energy Technology Data Exchange (ETDEWEB)

    Brown, J K

    1976-01-01

    Stem lengths and oven dry wt of stemwood and foilage were determined for shrubs in dia classes of 0 to 0.5 cm, 0.5 to 2 cm and 2 to 5 cm in various habitat types in Idaho and Montana. The logarithm of basal stem dia was closely correlated with the logarithm of wt. Regression components are presented for estimating leaf wt and total above-ground wt of 25 woody shrub species using a linear equation relating these 2 variables. Percentage stemwood wt is given for the 3 dia classes. Dia distributions for the smallest dia class were normal except for a few species with fine twigs; distributions for the other classes were positively skewed. Applications to forest fuel studies are briefly discussed.

  19. Estimating shrub biomass from basal stem diameters

    Energy Technology Data Exchange (ETDEWEB)

    Brown, J K

    1976-01-01

    Stem lengths and oven dry wt of stemwood and foilage were determined for shrubs in dia classes of 0 to 0.5 cm, 0.5 to 2 cm and 2 to 5 cm in various habitat types in Idaho and Montana. The logarithm of basal stem dia was closely correlated with the logarithm of wt. Regression components are presented for estimating leaf wt and total above-ground wt of 25 woody shrub species using a linear equation relating these 2 variables. Percentage stemwood wt is given for the 3 dia classes. Dia distributions for the smallest dia class were normal except for a few species with fine twigs: distributions for the other classes were positively skewed. Applications to forest fuel studies are briefly discussed.

  20. CT cisternography of the basal cisterns

    International Nuclear Information System (INIS)

    Galanski, M.; Dickob, M.; Wittkowski, W.; Muenster Univ.

    1986-01-01

    Air cisternograms at post mortem and positive contrast cisternograms on patients were performed in order to study intracisternal structures, particularly cranial nerves, as seen on CT. Air and contrast CT cisternograms showed excellent demonstration of the second, third, fifth, sixth, seventh and eighth cranial nerves. The ninth and tenth cranial nerves could not always be separated from each other and demonstration of the first, fourth, eleventh and twelfth cranial nerves was often not possible or was unsatisfactory. With a knowledge of the normal anatomy and of important surrounding structures, the individual cranial nerves are easily identified. The anthropologic baseline appears highly suitable for CT examination of the basal cisterns. The complementary coronal projection is also very valuable. (orig.) [de

  1. Concentrated insulins: the new basal insulins

    Directory of Open Access Journals (Sweden)

    Lamos EM

    2016-03-01

    Full Text Available Elizabeth M Lamos,1 Lisa M Younk,2 Stephen N Davis3 1Division of Endocrinology, Diabetes and Nutrition, 2Department of Medicine, University of Maryland School of Medicine, 3Department of Medicine, University of Maryland Medical Center, Baltimore, MD, USA Introduction: Insulin therapy plays a critical role in the treatment of type 1 and type 2 diabetes mellitus. However, there is still a need to find basal insulins with 24-hour coverage and reduced risk of hypoglycemia. Additionally, with increasing obesity and insulin resistance, the ability to provide clinically necessary high doses of insulin at low volume is also needed. Areas covered: This review highlights the published reports of the pharmacokinetic (PK and glucodynamic properties of concentrated insulins: Humulin-R U500, insulin degludec U200, and insulin glargine U300, describes the clinical efficacy, risk of hypoglycemic, and metabolic changes observed, and finally, discusses observations about the complexity of introducing a new generation of concentrated insulins to the therapeutic market. Conclusion: Humulin-R U500 has a similar onset but longer duration of action compared with U100 regular insulin. Insulin glargine U300 has differential PK/pharmacodynamic effects when compared with insulin glargine U100. In noninferiority studies, glycemic control with degludec U200 and glargine U300 is similar to insulin glargine U100 and nocturnal hypoglycemia is reduced. Concentrated formulations appear to behave as separate molecular entities when compared with earlier U100 insulin analog compounds. In the review of available published data, newer concentrated basal insulins may offer an advantage in terms of reduced intraindividual variability as well as reducing the injection burden in individuals requiring high-dose and large volume insulin therapy. Understanding the PK and pharmacodynamic properties of this new generation of insulins is critical to safe dosing, dispensing, and administration

  2. ESTIMATING BASAL ENERGY EXPENDITURE IN LIVER TRANSPLANT RECIPIENTS: THE VALUE OF THE HARRIS-BENEDICT EQUATION.

    Science.gov (United States)

    Pinto, Andressa S; Chedid, Marcio F; Guerra, Léa T; Álvares-DA-Silva, Mario R; Araújo, Alexandre de; Guimarães, Luciano S; Leipnitz, Ian; Chedid, Aljamir D; Kruel, Cleber R P; Grezzana-Filho, Tomaz J M; Kruel, Cleber D P

    2016-01-01

    Reliable measurement of basal energy expenditure (BEE) in liver transplant (LT) recipients is necessary for adapting energy requirements, improving nutritional status and preventing weight gain. Indirect calorimetry (IC) is the gold standard for measuring BEE. However, BEE may be estimated through alternative methods, including electrical bioimpedance (BI), Harris-Benedict Equation (HBE), and Mifflin-St. Jeor Equation (MSJ) that carry easier applicability and lower cost. To determine which of the three alternative methods for BEE estimation (HBE, BI and MSJ) would provide most reliable BEE estimation in LT recipients. Prospective cross-sectional study including dyslipidemic LT recipients in follow-up at a 735-bed tertiary referral university hospital. Comparisons of BEE measured through IC to BEE estimated through each of the three alternative methods (HBE, BI and MSJ) were performed using Bland-Altman method and Wilcoxon Rank Sum test. Forty-five patients were included, aged 58±10 years. BEE measured using IC was 1664±319 kcal for males, and 1409±221 kcal for females. Average difference between BEE measured by IC (1534±300 kcal) and BI (1584±377 kcal) was +50 kcal (p=0.0384). Average difference between the BEE measured using IC (1534±300 kcal) and MSJ (1479.6±375 kcal) was -55 kcal (p=0.16). Average difference between BEE values measured by IC (1534±300 kcal) and HBE (1521±283 kcal) was -13 kcal (p=0.326). Difference between BEE estimated through IC and HBE was less than 100 kcal for 39 of all 43patients. Among the three alternative methods, HBE was the most reliable for estimating BEE in LT recipients. Estimativa confiável do metabolismo basal em pacientes transplantados de fígado é necessária para adaptar os requerimentos energéticos, melhorar o estado nutricional e prevenir ganho de peso. Calorimetria indireta (CI) é o padrão-ouro para a medição do metabolismo basal. No entanto, ele pode ser estimado utilizando-se métodos alternativos

  3. Rommet som den tredje pedagog - En studie av pedagogers forståelse av rommets betydning - med fokus på estetisk virksomhet

    OpenAIRE

    Krokstad, Inger Elisabeth

    2014-01-01

    Masteroppgaven «Rommet som den tredje pedagog i tre Reggio Emilia-inspirerte barnehager. En studie av pedagogers forståelse av rommets betydning –med fokus på estetisk virksomhet» har til hensikt å bidra til økt kunnskap om estetisk virksomhet som er forbundet med Reggio Emilias tanke om rommet som den tredje pedagog. Avhandlingens problemstilling er: Hvilke mønster kan identifiseres i barnehagepedagogens forståelse av rommet som den tredje pedagog-med fokus på estetisk virksomhet? ...

  4. Multi-digit handwritten sindhi numerals recognition using som neural network

    International Nuclear Information System (INIS)

    Chandio, A.A.; Jalbani, A.H.; Awan, S.A.

    2017-01-01

    In this research paper a multi-digit Sindhi handwritten numerals recognition system using SOM Neural Network is presented. Handwritten digits recognition is one of the challenging tasks and a lot of research is being carried out since many years. A remarkable work has been done for recognition of isolated handwritten characters as well as digits in many languages like English, Arabic, Devanagari, Chinese, Urdu and Pashto. However, the literature reviewed does not show any remarkable work done for Sindhi numerals recognition. The recognition of Sindhi digits is a difficult task due to the various writing styles and different font sizes. Therefore, SOM (Self-Organizing Map), a NN (Neural Network) method is used which can recognize digits with various writing styles and different font sizes. Only one sample is required to train the network for each pair of multi-digit numerals. A database consisting of 4000 samples of multi-digits consisting only two digits from 10-50 and other matching numerals have been collected by 50 users and the experimental results of proposed method show that an accuracy of 86.89% is achieved. (author)

  5. Proactive Review som læringsrum for online-ledere

    DEFF Research Database (Denmark)

    Kolbæk, Ditte

    2017-01-01

    . Kapitlet undersøger, hvordan online lederen kan lære af erfaringer skabt i hans/hendes online team. Kapitlet tager udgangspunkt i Engeströms virksomhedsteori og Proactive Review som praksisser for, hvordan ledere konkret kan lære sammen med deres team (Kolbæk 2011). Kapitlet udvikler en model for lederens...... læring på basis af ovenstående teorier. Da læring og kommunikation i teamet foregår online, er det nærliggende at benytte netnografi som metodisk tilgang. Kapitlet undersøger online lederens læringsrum i en global IT virksomhed, hvor Proactive Reviews er implementeret i flere end 40 lande......, at medarbejdere og ledere opholder sig i forskellige lande, og at de kun sjældent eller måske aldrig mødes fysisk, men altid samarbejder og kommunikerer online. Kapitlet kalder det online teams og online ledelse. Dette kapitel fokuserer på lederens læring i et læringsrum, hvor ledelse og samarbejde foregår online...

  6. Differences in SOM decomposition and temperature sensitivity among soil aggregate size classes in a temperate grasslands.

    Directory of Open Access Journals (Sweden)

    Qing Wang

    Full Text Available The principle of enzyme kinetics suggests that the temperature sensitivity (Q10 of soil organic matter (SOM decomposition is inversely related to organic carbon (C quality, i.e., the C quality-temperature (CQT hypothesis. We tested this hypothesis by performing laboratory incubation experiments with bulk soil, macroaggregates (MA, 250-2000 μm, microaggregates (MI, 53-250 μm, and mineral fractions (MF, MF>bulk soil >MI(P <0.05. The Q10 values were highest for MA, followed (in decreasing order by bulk soil, MF, and MI. Similarly, the activation energies (Ea for MA, bulk soil, MF, and MI were 48.47, 33.26, 27.01, and 23.18 KJ mol-1, respectively. The observed significant negative correlations between Q10 and C quality index in bulk soil and soil aggregates (P<0.05 suggested that the CQT hypothesis is applicable to soil aggregates. Cumulative C emission differed significantly among aggregate size classes (P <0.0001, with the largest values occurring in MA (1101 μg g-1, followed by MF (976 μg g-1 and MI (879 μg g-1. These findings suggest that feedback from SOM decomposition in response to changing temperature is closely associated withsoil aggregation and highlights the complex responses of ecosystem C budgets to future warming scenarios.

  7. Effect of microbial enzyme allocation strategies on stoichiometry of soil organic matter (SOM) decomposition

    Science.gov (United States)

    Wutzler, Thomas

    2014-05-01

    We explored different strategies of soil microbial community to invest resources into extracellular enzymes by conceptual modelling. Similar to the EEZY model by Moorhead et al. (2012), microbial community can invest into two separate pools of enzymes that depolymerize two different SOM pools. We show that with assuming that a fixed fraction of substrate uptake is allocated to enzymes, the microbial dynamics decouples from decomposition dynamics. We propose an alternative formulation where investment into enzymes is proportional to microbial biomass. Next, we show that the strategy of optimizing stoichiometry of decomposition flux according to microbial biomass stoichiometry yield less microbial growth than the strategy of optimizing revenue of the currently limiting element. However, both strategies result in better usage of the resources, i.e. less C overflow or N mineralization, than the strategy of equal allocation to both enzymes. Further, we discuss effects of those strategies on decomposition of SOM and priming at different time scales and discuss several abstractions from the detailed model dynamics for usage in larger scale models.

  8. Brand management og den refleksive forbruger - med semiotik som hjælpedisciplin

    DEFF Research Database (Denmark)

    Hermansen, Judy

    2009-01-01

      Kritisk eftertanke er et væsentligt træk ved den refleksive forbruger - ofte parret med en vis negativitet overfor et brand, en reklame eller forbrugerisme i al almindelighed. Den refleksive forbrugertype kommer til udtryk hos for eksempel en anti-branding guru som Naomi Klein og hendes...... bestseller bog "No Logo" eller i græsrodsbevægelsen Adbusters ( https://www.adbusters.org/ ), der efterhånden i mange år har udsendt et månedsmagasin med kritik af forbrugersamfundet og al dets reklame og branding. Disse anti-forbrugs og anti-branding bevægelser udspringer af, og er identifikationspunkter...... - den refleksive forbruger skal have noget, der kan "brande" ham som anderledes end alle mainstreamforbrugerne. Den refleksive forbruger er med andre ord en Feinschmecker og i lighed med - eller måske rettere i endnu højere grad end - alle andre forbrugere signalerer den refleksive forbruger sin...

  9. Hvad kan du tilbyde mig som muslim, præst?

    DEFF Research Database (Denmark)

    Skovsgaard, Steen

    2005-01-01

    . islam og kristendom var jeg i 1995 inviteret til et møde med en stor gruppe muslimer i Gellerup. Det var et debatmøde om islam og kristendom, hvor skoleleder og imam Abdul Wahid Pedersen og jeg skulle komme med oplæg og debattere. Og så kunne der efterfølgende stilles spørgsmål fra salen. Det var hér...... andre mennesker, eller om Gud elsker dig og vil ha’ noget med dig at gøre, den dag må du love mig at komme tilbage. For så har jeg noget at tilbyde dig. Indtil da må du nøjes med islam!” Et sådant svar ville ganske vist ha’ været længere, men der ville også ha’ været mere for den unge muslim at tænke på...... og overkommelige krav, som stilles dig i islam. Selv her har du svigtet og er skyldig! Skyldig til dom og til straf!”. Og hvis så muslimen skulle finde på at sige, at han da bestemt har opfyldt Guds vilje iflg. islam, så kan vi jo passende fortælle ham, at de krav som stilles i islam kun er en bleg...

  10. Tester og testtilbakemeldinger som direkte bidragsytere til dypere læring blant studenter

    Directory of Open Access Journals (Sweden)

    Henrik Herrebrøden

    2014-11-01

    Full Text Available Denne artikkelen diskuterer forskning som tilsier at tester og testtilbakemeldinger kan bidra til dypere læring blant studenter. Testing har vist seg å forbedre langtidshukommelsen av innlært kunnskap sammenlignet med repetert lesing, noe som kalles for testeffekten. For at testeffekten skal optimaliseres, bør tester utformes med mål om å bidra til dyp prosessering av innlært kunnskap. Testtilbakemeldingers rolle i utdanning kan være å bidra til økt metakognitiv selvregulering blant studenter. For at selvregulering skal promoteres best mulig, bør testtilbakemeldinger inneholde utdypende informasjon. Samlet ser tester og testtilbakemeldinger ut til å være nyttige læringsverktøy og potensielle bidragsytere til dypere læring blant studenter.AbstractThis article discusses research supporting that tests and test feedback are learning tools that may promote deeper learning among students. Testing improves long-term retention of knowledge compared to repeated study, a phenomenon known as the testing effect. In order to promote the testing effect, tests should facilitate deep processing of knowledge among students. Test feedback has the potential to increase students’ metacognitive self-regulation. For this type of metacognition to be enhanced, feedback should contain elaborate information. Conclusively, tests and test feedback appear to be valuable learning tools and potential promoters of deeper learning.

  11. Praksisnær skoleudvikling og PLC som strategisk udviklingsaktør

    DEFF Research Database (Denmark)

    Christensen, Ole; Bach, Anna

    2017-01-01

    I det følgende belyses, hvorledes PLC kan udvikles som strategisk udviklingsaktør og understøtte praksisnær skoleudvikling. Vi ønsker at belyse hvorledes Bekendtgørelsens overordnede intentioner kan få retning og rammer og dermed medvirke til, at hele det pædagogiske personale indgår i skoleudvik......I det følgende belyses, hvorledes PLC kan udvikles som strategisk udviklingsaktør og understøtte praksisnær skoleudvikling. Vi ønsker at belyse hvorledes Bekendtgørelsens overordnede intentioner kan få retning og rammer og dermed medvirke til, at hele det pædagogiske personale indgår i...... skoleudviklingen. I den forbindelse er det vores erfaring, at PLC kan spille en central rolle i forbindelse med den praksisnære og lokale skoleudvikling. Erfaringerne bygger især på udviklings- og forskningsprojekter fra kommunerne Kolding, København, Roskilde og Tårnby. Der har været tale om praksisnære...

  12. Designtænkning som didaktisk metode: Læringsdesign for teknologisk forestillingskraft og handlekraft

    Directory of Open Access Journals (Sweden)

    Rikke Berggreen Paaskesen

    2016-11-01

    Full Text Available Det er et problem, at undervisere, lærerstuderende og elever ikke bliver mødt med tilstrækkelig inspiration, metoder og design til, hvorledes de kan anvende teknologier i undervisningen på måder der understøtter teknologisk forestillingskraft, handlekraft og kritisk-kreativ teknologisk dannelse. Dette forsøger denne artikel at adressere gennem at tilbyde forståelsesramme, struktur, procesmodel og konkret case-eksempel for hvorledes man kan arbejde med designtænkning som didaktisk metode til udformning læringsdesign for kritisk-kreativ teknologisk forestillingskraft og handlekraft. Artiklen kobler designtænkning og læringsdesign sammen til designtænkende læringsdesign for undervisere og læringsdesign for designtænkning for studerende og elever. Disse formater beskrives dernæst som åbne didaktisk-pædagogiske læringsdesign og centrale strukturer, elementer og faser fremstilles og beskrives. Pædagogisk tænkning for kritisk-kreativt medborgerskab inddrages til at underbygge modellens didaktisk-pædagogiske potentiale. Designtænkende læringsdesign for demokratisk dannelse præsenteres dernæst gennem en konkret case Future-Tech-Town Year 2060. I konklusionen udvides perspektivet til uddannelsesarbejde med læringsdesign der sigter mod kritisk-kreative fremtids-skabere med teknologier.

  13. A Classic Case of Basal Cell Nevus Syndrome

    Directory of Open Access Journals (Sweden)

    Dattaprasad Dadhe

    2015-01-01

    Full Text Available The basal cell nevus syndrome is an autosomal dominant inherited condition characterized mainly by basal cell carcinomas, multiple keratinizing odontogenic tumors, and other systemic anomalies. As these manifestations do not alter the patient′s lifestyle, most of the cases are diagnosed through oral abnormalities. A classic case of basal cell nevus syndrome fulfilling almost all the major and minor criteria has been reported here.

  14. Immunohistochemical Characteristics of Triple Negative/Basal-like Breast Cancer

    OpenAIRE

    Emel Ebru PALA; Ümit BAYOL; Süheyla CUMURCU; Elif KESKİN

    2012-01-01

    Objective: Triple-negative-breast-cancer that accounts for 10-20% of all breast carcinomas is defined by the lack of estrogen receptor, progesterone receptor, HER2 expression, and agressive clinical behavior. Triple-negative-breast-cancer is categorized into basal like and other types. The basal-like subtype is characterized by the expression of myoepithelial/basal markers.Material and Method: We studied 41 immunohistochemically triplenegative- breast-cancer patients to determine EGFR, Cytoke...

  15. Basal Cell Carcinoma Arising in a Tattooed Eyebrow

    Science.gov (United States)

    Lee, Jong-Sun; Park, Jin; Kim, Seong-Min; Kim, Han-Uk

    2009-01-01

    Malignant skin tumors, including squamous cell carcinoma and malignant melanoma, have occurred in tattoos. Seven documented cases of basal cell carcinoma associated with tattoos have also been reported in the medical literature. We encountered a patient with basal cell carcinoma in a tattooed eyebrow. We report on this case as the eighth reported case of a patient with basal cell carcinoma arising in a tattooed area. PMID:20523804

  16. Efeito da remoção de células somáticas pela microfiltração sobre a lipólise do leite

    Directory of Open Access Journals (Sweden)

    Marcos Veiga dos Santos

    2007-10-01

    Full Text Available O objetivo do presente estudo foi avaliar o efeito da retirada mecânica das células somáticas do leite cru sobre a taxa de lipólise durante o armazenamento refrigerado do leite pasteurizado. O delineamento experimental utilizado foi totalmente casualizado, com três repetições e arranjo fatorial de tratamentos 2 X 2 X 2, constituídos por dois nível de gordura do leite (desnatado e integral, dois níveis de contagem de células somáticas (CCS baixa - CCSB e CCS alta - CCSA, e pela aplicação ou não da microfiltração ao leite. Três lotes de leite cru CCSB (75.000 cél./mL e CCSA (1.150.000 cél./mL foram obtidos de vacas selecionadas e submetidos ao desnate centrífugo, à microfiltração em sistema a vácuo, sendo em seguida pasteurizados e armazenados por 21 dias sob refrigeração a 6ºC. Foram realizadas medidas repetidas no tempo, as quais corresponderam aos dias de coleta do leite pasteurizado durante o período de armazenamento (1, 7, 14 e 21. A microfiltração associada ao desnate foram eficazes na remoção das células somáticas do leite, com reduções de 92,5 e 99,5% para o leite CCSB e CCSA, respectivamente. A lipólise do leite aumentou em função do tempo de armazenamento e foi maior para o leite microfiltrado, contudo não sofreu influência da CCS. Independentemente da CCS, ocorreu aumento da lipólise do leite pasteurizado durante o período de armazenamento.

  17. Basal-body-associated macromolecules: a continuing debate.

    Science.gov (United States)

    Pierre Mignot, J; Brugerolle, G; Didier, P; Bornens, M

    1993-07-01

    Controversy over the possibility that centrioles/basal bodies contain nucleic acids has overshadowed results demonstrating other macromolecules in the lumen of these organelles. Glycogen particles, which are known to be present within the lumen of the centriole/basal body of sperm cells, have now been found in basal bodies of protists belonging to three different groups. Here, we extend the debate on a role for RNA in basal body/centriole function and speculate on the origin and the function of centriolar glycogen.

  18. High dimension feature extraction based visualized SOM fault diagnosis method and its application in p-xylene oxidation process☆

    Institute of Scientific and Technical Information of China (English)

    Ying Tian; Wenli Du; Feng Qian

    2015-01-01

    Purified terephthalic acid (PTA) is an important chemical raw material. P-xylene (PX) is transformed to terephthalic acid (TA) through oxidation process and TA is refined to produce PTA. The PX oxidation reaction is a complex process involving three-phase reaction of gas, liquid and solid. To monitor the process and to im-prove the product quality, as wel as to visualize the fault type clearly, a fault diagnosis method based on self-organizing map (SOM) and high dimensional feature extraction method, local tangent space alignment (LTSA), is proposed. In this method, LTSA can reduce the dimension and keep the topology information simultaneously, and SOM distinguishes various states on the output map. Monitoring results of PX oxidation reaction process in-dicate that the LTSA–SOM can wel detect and visualize the fault type.

  19. Importancia del conteo de células somáticas en la calidad de la leche

    OpenAIRE

    Hernández Reyes, Juan Manuel; Bedolla Cedeño, José Luís Carlos

    2008-01-01

    Este trabajo es una revisión sobre la importancia de las células somáticas en la calidad de la leche. Las células somáticas son, entre otras, células blancas propias del organismo que le sirven como defensa a la glándula mamaria de la vaca contra organismos patógenos. La determinación del contenido de células somáticas de la leche del tanque, o de los cuartos de la glándula mamaria de las vacas, es el medio auxiliar de diagnóstico más importante para juzgar el estado de salud de la ubre de un...

  20. Fra <em>Oklahoma!> til <em>Beauty and the Beastem>

    DEFF Research Database (Denmark)

    Nielsen, Steen Kaargaard

    2010-01-01

    Artiklens formål er at bidrage til en belysning af Original Broadway Cast-albummets historiske udvikling til og som distinkt fonografisk undergenre i den amerikanske produktion af musical-album. På baggrund af en kort introduktion til amerikansk musical-musik som fonografisk fænomen med definition...... konventionaliseringen af det kommercielle OBC-album behandles primært i en økonomisk, industrikulturel og teknologisk kontekstualisering....

  1. Acarofauna em plantas ornamentais

    Directory of Open Access Journals (Sweden)

    Jania Claudia Camilo dos Santos

    2014-10-01

    Full Text Available Normal 0 21 false false false PT-BR X-NONE X-NONE O cultivo e o comercio de plantas ornamentais vem cada vez mais ganhando espaço no Brasil, pela grande variedade das espécies existentes e exuberância de suas flores, que oferecem uma maior riqueza ao local. Dessa forma, o objetivo desse trabalho foi realizar o levantamento da população de ácaros associados às plantas ornamentais no município de Arapiraca-AL, em função dos diversos problemas acarretados por essa espécie. O levantamento foi realizado entre os meses de abril a março, através de amostragens mensais de folhas coletadas da parte basal, intermediária e apical de plantas existentes em praças e jardins. Foram coletados 55 ácaros pertencentes à ordem Prostigmata em 20 famílias de plantas. As plantas com as maiores riquezas de ácaros foram as Coleus blumei L. e Bxuxus sempervirens L., que apresentaram 65% dos valores amostrais. Analisando-se as coletas realizadas, pode-se observar que houve uma maior incidência populacional de ácaros na coleta do mês de maio, cuja percentagem foi de 36% de ácaros levantados, sendo que no levantamento dos dados amostrais de março a percentagem encontrada foi de 14%, nas amostragens dos meses de abril e junho, a percentagem amostrada dos dados foi de 22 e 28%, respectivamente. O estudo do levantamento de ácaros em plantas ornamentais permitiu observar a relação entre ácaros e a relação com a planta hospedeira, facilitando posteriormente um estudo mais aprofundado sobre plantas hospedeiras, e pode-se observar que em períodos chuvosos ocorre uma menor incidência populacional.

  2. Modelling the initiation of basal sliding

    Science.gov (United States)

    Mantelli, E.; Schoof, C.

    2017-12-01

    The initiation of basal sliding is a thermally-controlled process that affects ice speed, englacial heat transport, and melt water production at the bed, and ultimately influences the large-scale dynamics of ice sheets. From a modelling perspective, describing the onset of sliding in thin-film models suitable for ice sheet scale simulations is problematic. In particular, previous work concluded that, under shallow-ice mechanics, the scenario of a hard switch from frozen to molten bed leads to an infinite vertical velocity at the onset, and higher-order mechanical formulations are needed to describe sliding initiation. An alternative view considers the occurrence of subtemperate sliding, which allows for a smooth sliding velocity across the onset. However, the sliding velocity decreases rapidly as temperature drops below the melting point, thus raising the issue of whether a mechanical model that does not resolve the ice sheet thickness scale is ever appropriate to model the onset of sliding. In this study we first present a boundary layer model for the hard switch scenario. Our analysis, which considers a thermo-mechanically coupled Stokes flow near the onset, shows that the abrupt onset of sliding is never possible. In fact, the acceleration of ice flow deflects the flowlines towards the bed, which freezes again immediately downstream to the onset. This leads to the conclusion that the sliding velocity must change smoothly across the onset, thus the temperature dependence of sliding needs to be taken into account. In this context, we examine a limiting case of standard temperature-dependent sliding laws, where sliding onset takes the form of an extended transition region interposed between fully frozen and temperate bed. In the transition region basal temperature is at the melting point, and the sliding velocity varies smoothly as dictated by the energy budget of the bed. As the extent of this region is not small compared to the ice sheet length scale, we couple

  3. Nevoid basal cell carcinoma syndrome (Gorlin syndrome

    Directory of Open Access Journals (Sweden)

    Lo Muzio Lorenzo

    2008-11-01

    Full Text Available Abstract Nevoid basal cell carcinoma syndrome (NBCCS, also known as Gorlin syndrome, is a hereditary condition characterized by a wide range of developmental abnormalities and a predisposition to neoplasms. The estimated prevalence varies from 1/57,000 to 1/256,000, with a male-to-female ratio of 1:1. Main clinical manifestations include multiple basal cell carcinomas (BCCs, odontogenic keratocysts of the jaws, hyperkeratosis of palms and soles, skeletal abnormalities, intracranial ectopic calcifications, and facial dysmorphism (macrocephaly, cleft lip/palate and severe eye anomalies. Intellectual deficit is present in up to 5% of cases. BCCs (varying clinically from flesh-colored papules to ulcerating plaques and in diameter from 1 to 10 mm are most commonly located on the face, back and chest. The number of BBCs varies from a few to several thousand. Recurrent jaw cysts occur in 90% of patients. Skeletal abnormalities (affecting the shape of the ribs, vertebral column bones, and the skull are frequent. Ocular, genitourinary and cardiovascular disorders may occur. About 5–10% of NBCCS patients develop the brain malignancy medulloblastoma, which may be a potential cause of early death. NBCCS is caused by mutations in the PTCH1 gene and is transmitted as an autosomal dominant trait with complete penetrance and variable expressivity. Clinical diagnosis relies on specific criteria. Gene mutation analysis confirms the diagnosis. Genetic counseling is mandatory. Antenatal diagnosis is feasible by means of ultrasound scans and analysis of DNA extracted from fetal cells (obtained by amniocentesis or chorionic villus sampling. Main differential diagnoses include Bazex syndrome, trichoepithelioma papulosum multiplex and Torre's syndrome (Muir-Torre's syndrome. Management requires a multidisciplinary approach. Keratocysts are treated by surgical removal. Surgery for BBCs is indicated when the number of lesions is limited; other treatments include laser

  4. Nordkapp som bærekraftig destinasjon - Et case-studie av aktørers drivere og barrierer

    OpenAIRE

    Berg, Marianne; Røkholt, Solveig

    2016-01-01

    Tittelen på oppgaven er “Nordkapp som bærekraftig destinasjon: Et case-studie av aktørers drivere og barrierer”. Vi har utviklet problemstillingen: “Hvilke drivere og barrierer ligger til grunn for utviklingen av et bærekraftig reiseliv blant aktørene på destinasjon Nordkapp?” Temaet vi ønsker å ta for oss er derfor bærekraftig destinasjonsutvikling på naturdestinasjoner. Bærekraft er en tematikk som må tas hensyn til for reiselivets overlevelsesevne. For å undersøke dette har vi brukt et kva...

  5. Impact of Basal Conditions on Grounding-Line Retreat

    Science.gov (United States)

    Koellner, S. J.; Parizek, B. R.; Alley, R. B.; Muto, A.; Holschuh, N.; Nowicki, S.

    2017-12-01

    An often-made assumption included in ice-sheet models used for sea-level projections is that basal rheology is constant throughout the domain of the simulation. The justification in support of this assumption is that physical data for determining basal rheology is limited and a constant basal flow law can adequately approximate current as well as past behavior of an ice-sheet. Prior studies indicate that beneath Thwaites Glacier (TG) there is a ridge-and-valley bedrock structure which likely promotes deformation of soft tills within the troughs and sliding, more akin to creep, over the harder peaks; giving rise to a spatially variable basal flow law. Furthermore, it has been shown that the stability of an outlet glacier varies with the assumed basal rheology, so accurate projections almost certainly need to account for basal conditions. To test the impact of basal conditions on grounding-line evolution forced by ice-shelf perturbations, we modified the PSU 2-D flowline model to enable the inclusion of spatially variable basal rheology along an idealized bedrock profile akin to TG. Synthetic outlet glacier "data" were first generated under steady-state conditions assuming a constant basal flow law and a constant basal friction coefficient field on either a linear or bumpy sloping bed. In following standard procedures, a suite of models were then initialized by assuming different basal rheologies and then determining the basal friction coefficients that produce surface velocities matching those from the synthetic "data". After running each of these to steady state, the standard and full suite of models were forced by drastically reducing ice-shelf buttressing through side-shear and prescribed basal-melting perturbations. In agreement with previous findings, results suggest a more plastic basal flow law enhances stability in response to ice-shelf perturbations by flushing ice from farther upstream to sustain the grounding-zone mass balance required to prolong the

  6. Herodot og <em>hemerodromoi>

    DEFF Research Database (Denmark)

    Schwartz, Adam; Nielsen, Thomas Heine

    2006-01-01

    Denne artikel er en tilbundsgående undersøgelse af brugen af langdistanceløbere (hemerodromoi) om budbringere i Grækenland i klassisk og arkaisk oldtid i såvel militært som civilt regi. Udgivelsesdato: April......Denne artikel er en tilbundsgående undersøgelse af brugen af langdistanceløbere (hemerodromoi) om budbringere i Grækenland i klassisk og arkaisk oldtid i såvel militært som civilt regi. Udgivelsesdato: April...

  7. Patterned basal seismicity shows sub-ice stream bedforms

    Science.gov (United States)

    Barcheck, C. G.; Tulaczyk, S. M.; Schwartz, S. Y.

    2017-12-01

    Patterns in seismicity emanating from the bottom of fast-moving ice streams and glaciers may indicate localized patches of higher basal resistance— sometimes called 'sticky spots', or otherwise varying basal properties. These seismogenic basal areas resist an unknown portion of the total driving stress of the Whillans Ice Plain (WIP), in West Antarctica, but may play an important role in the WIP stick-slip cycle and ice stream slowdown. To better understand the mechanism and importance of basal seismicity beneath the WIP, we analyze seismic data collected by a small aperture (micro-earthquakes in Dec 2014, and we compare the resulting map of seismicity to ice bottom depth measured by airborne radar. The number of basal earthquakes per area within the network is spatially heterogeneous, but a pattern of two 400m wide streaks of high seismicity rates is evident, with >50-500 earthquakes detected per 50x50m grid cell in 2 weeks. These seismically active streaks are elongated approximately in the ice flow direction with a spacing of 750m. Independent airborne radar measurements of ice bottom depth from Jan 2013 show a low-amplitude ( 5m) undulation in the basal topography superposed on a regional gradient in ice bottom depth. The flow-perpendicular wavelength of these low-amplitude undulations is comparable to the spacing of the high seismicity bands, and the streaks of high seismicity intersect local lows in the undulating basal topography. We interpret these seismic and radar observations as showing seismically active sub-ice stream bedforms that are low amplitude and elongated in the direction of ice flow, comparable to the morphology of mega scale glacial lineations (MSGLs), with high basal seismicity rates observed in the MSGL troughs. These results have implications for understanding the formation mechanism of MSGLS and well as understanding the interplay between basal topographic roughness, spatially varying basal till and hydrologic properties, basal

  8. Distrofia de la membrana basal epitelial

    Directory of Open Access Journals (Sweden)

    Zaadia Pérez Parra

    Full Text Available La distrofia de Cogan es la distrofia corneal anterior más común, frecuente en adultos del sexo femenino, entre 40-70 años de edad. Presentamos un caso de una paciente de 50 años de edad, del sexo femenino, quien refiere visión borrosa, lagrimeo y fotofobia. Al examen de la córnea en lámpara de hendidura se observan imágenes de color grisáceo en forma de huellas dactilares y de mapa. Esta afección es causada por alteraciones de la membrana basal epitelial que provoca la separación parcial o total del epitelio corneal. Generalmente asintomática, es la causa más frecuente de erosión corneal recurrente. Las opciones terapéuticas varían desde lubricantes, soluciones hipertónicas tópicas, lentes de contacto de vendaje, desbridamiento del epitelio central, micropunciones mecánicas o diatermia y fotoqueratectomía con láser excímer.

  9. Does basal metabolic rate drive eating rate?

    Science.gov (United States)

    Henry, Christiani Jeyakumar; Ponnalagu, Shalini; Bi, Xinyan; Forde, Ciaran

    2018-05-15

    There have been recent advances in our understanding of the drivers of energy intake (EI). However, the biological drivers of differences in eating rate (ER) remain less clear. Studies have reported that the fat-free mass (FFM) and basal metabolic rate (BMR) are both major components that contribute to daily energy expenditure (EE) and drive EI. More recently, a number of observations report that higher ER can lead to greater EI. The current study proposed that adults with a higher BMR and higher energy requirements would also exhibit higher ERs. Data on BMR, FFM, and ER were collected from 272 Chinese adults (91 males and 181 females) in a cross-sectional study. Analysis showed significant positive associations between BMR and ER (r s  = 0.405, p BMR explained about 15% of the variation in ER which was taken to be metabolically significant. This association provides metabolic explanation that the differences in an individual's BMR (hence energy requirements) may be correlated with ERs. This merits further research. Copyright © 2018 Elsevier Inc. All rights reserved.

  10. Fluctuating selection on basal metabolic rate.

    Science.gov (United States)

    Nilsson, Johan F; Nilsson, Jan-Åke

    2016-02-01

    BMR (Basal metabolic rate) is an important trait in animal life history as it represents a significant part of animal energy budgets. BMR has also been shown to be positively related to sustainable work rate and maximal thermoregulatory capacity. To this date, most of the studies have focused on the causes of interspecific and intraspecific variation in BMR, and fairly little is known about the fitness consequences of different metabolic strategies. In this study, we show that winter BMR affects local survival in a population of wild blue tits (Cyanistes caeruleus), but that the selection direction differs between years. We argue that this fluctuating selection is probably a consequence of varying winter climate with a positive relation between survival and BMR during cold and harsh conditions, but a negative relation during mild winters. This fluctuating selection can not only explain the pronounced variation in BMR in wild populations, but will also give us new insights into how energy turnover rates can shape the life-history strategies of animals. Furthermore, the study shows that the process of global warming may cause directional selection for a general reduction in BMR, affecting the general life-history strategy on the population level.

  11. Suplementação de vacas leiteiras com homeopatia: células somáticas do leite, cortisol e imunidade

    Directory of Open Access Journals (Sweden)

    J.R.M. Silva

    2011-08-01

    Full Text Available Avaliou-se o efeito da suplementação de uma combinação homeopática sobre a contagem de células somáticas do leite (CCS, o teor sanguíneo de cortisol e a resposta de anticorpos neutralizantes antivírus da raiva de vacas leiteiras. Trinta e duas vacas Holandesas em lactação foram blocadas em pares e aleatoriamente alocadas a um de dois tratamentos por 63 dias, posterior a um período de padronização de 14 dias. A CCS mensurada no final da padronização ajustou os valores semanais de CCS no modelo de análise estatística. Os tratamentos foram: 150 gramas de uma combinação homeopática (Hypothalamus, 10-30; Colibacilinum, 10-30; Streptococus Beta Hemolyticum, 10-60; Streptococus Uberis, 10-60; Phytolacca, 10-60; Calcium Phosphoricum, 10-30; Natrum Muriaticum, 10-60; Urtica Urens, 10-30; Silicea Terra, 10-400 em veículo mineral, ou 150 gramas do mesmo veículo mineral (controle. A homeopatia tendeu a aumentar a CCS de 124 para 222 x1.000 células mL-1 (P=0,09 e a CCS linearizada (P=0,08. Não foram detectados efeitos de tratamento sobre a concentração sérica de cortisol após estresse induzido por aspiração percutânea do saco ventral do rúmen (P=0,59 ou sobre o título de anticorpos neutralizantes em resposta à vacinação antivírus da raiva (P=0,40. A suplementação com homeopatia tendeu a aumentar a CCS de vacas com baixa CCS.

  12. A whole stand basal area projection model for Appalachian hardwoods

    Science.gov (United States)

    John R. Brooks; Lichun Jiang; Matthew Perkowski; Benktesh Sharma

    2008-01-01

    Two whole-stand basal area projection models were developed for Appalachian hardwood stands. The proposed equations are an algebraic difference projection form based on existing basal area and the change in age, trees per acre, and/or dominant height. Average equation error was less than 10 square feet per acre and residuals exhibited no irregular trends.

  13. Basal cell epithelioma (carcinoma) in children and teenagers

    Energy Technology Data Exchange (ETDEWEB)

    Rahbari, H.; Mehregan, A.H.

    1982-01-15

    Among over 390,000 routine dermatopathologic specimens there were 85 cases diagnosed as basal cell epithelioma (carcinoma) (BCE) in persons 19 years old or younger. This number was refined to 40 cases de novo BCE in children and teenagers. Basal cell epithelioma unrelated to other conditions is rare in the young and it should be differentiated from similar fibroepithelial growths.

  14. computed tomography features of basal ganglia and periventricular

    African Journals Online (AJOL)

    HIV is probably the most common cause of basal ganglia and periventricular calcification today. on-enhanced computed tomography (NECT) shows diffuse cerebral atrophy in 90% of cases. Bilateral, symmetrical basal ganglia calcification is seen in 30% of cases, but virtually never before 1 year of age.1. CMV (FIG.2).

  15. Amyloid in basal cell carcinoma and seborrheic keratosis

    DEFF Research Database (Denmark)

    Olsen, K E; Westermark, Per

    1994-01-01

    The frequency of amyloid substance was studied in two different types of skin tumours: basal cell carcinoma and seborrheic keratosis. In 9 out of 49 cases of seborrheic keratosis amyloid substance was found. In the basal cell carcinomas, 194 out of 260 cases showed amyloid deposits, a rate...

  16. Adenoid basal hyperplasia of the uterine cervix: a lesion of reserve cell type, distinct from adenoid basal carcinoma.

    Science.gov (United States)

    Kerdraon, Olivier; Cornélius, Aurélie; Farine, Marie-Odile; Boulanger, Loïc; Wacrenier, Agnès

    2012-12-01

    Adenoid basal hyperplasia is an underrecognized cervical lesion, resembling adenoid basal carcinoma, except the absence of deep invasion into the stroma. We report a series of 10 cases, all extending less than 1 mm from the basement membrane. Our results support the hypothesis that adenoid basal hyperplasia arises from reserve cells of the cervix. Lesions were found close to the squamocolumnar junction, in continuity with the nearby subcolumnar reserve cells. They shared the same morphology and immunoprofile using a panel of 4 antibodies (keratin 5/6, keratin 14, keratin 7 and p63) designed to differentiate reserve cells from mature squamous cells and endocervical columnar cells. We detected no human papillomavirus infection by in situ hybridization targeting high-risk human papillomavirus, which was concordant with the absence of immunohistochemical p16 expression. We demonstrated human papillomavirus infection in 4 (80%) of 5 adenoid basal carcinoma, which is in the same range as previous studies (88%). Thus, adenoid basal hyperplasia should be distinguished from adenoid basal carcinoma because they imply different risk of human papillomavirus infection and of subsequent association with high-grade invasive carcinoma. In our series, the most reliable morphological parameters to differentiate adenoid basal hyperplasia from adenoid basal carcinoma were the depth of the lesion and the size of the lesion nests. Furthermore, squamous differentiation was rare in adenoid basal hyperplasia and constant in adenoid basal carcinoma. Finally, any mitotic activity and/or an increase of Ki67 labeling index should raise the hypothesis of adenoid basal carcinoma. Copyright © 2012 Elsevier Inc. All rights reserved.

  17. (REARRANJOS DE UMA “UTOPIA DO SOM NACIONAL”: a bossa nova como realização do projeto musical modernista de Mário de Andrade(REARRANGEMENTS OF A “UTOPIA OF A NATIONAL SOUND”

    Directory of Open Access Journals (Sweden)

    Manoel Dourado Bastos

    2009-06-01

    Full Text Available O presente trabalho procura argumentar sobre a relação histórica entre o projeto de Mário de Andrade para a música brasileira (sua “utopia do som nacional”, segundo Arnaldo Contier e sua uma realização possível com a bossa nova. Apresenta-se em linhas gerais o referido projeto andradiano, seu caráter engajado, suas incursões na problemática do “popular” e do “erudito” e sua filiação à obsessão nacional pela formação. Expõe-se pontualmente a possível compreensão da bossa nova como um projeto modernista, sugerindo uma lógica de continuidade na experiência musical brasileira.

  18. Patterns of protein and carbohydrate accumulation during somatic embryogenesis of Acca sellowiana Padrões de acúmulo de proteínas e carboidratos durante a embriogênese somática de Acca sellowiana

    Directory of Open Access Journals (Sweden)

    Gabriela Claudia Cangahuala-Inocente

    2009-03-01

    Full Text Available The aim of this work was to quantify the protein, starch and total sugars levels during histodifferentiation and development of somatic embryos of Acca sellowiana Berg. For histological observations, the samples were dehydrated in a battery of ethanol, embedded in historesin and stained with toluidine blue (morphology, coomassie blue (protein bodies and periodic acid-Schiff (starch. Proteins were extracted using a buffer solution, precipitated using ethanol and quantified using the Bradford reagent. Total sugars were extracted using a methanol-chloroform-water (12:5:3 solution and quantified by a reaction with anthrone at 0.2%. Starch was extracted using a 30% perchloric acid solution and quantified by a reaction with anthrone at 0.2%. During the somatic embryogenesis' in vitro morphogenesis and differentiation processes, the total protein levels decreased and the soluble sugars levels increased during the first 30 days in culture and remained stable until the 120th day. On the other hand, total protein levels increased according to the progression in the developmental stages of the somatic embryos. The levels of total sugars and starch increased in the heart and cotyledonary stages, and decreased in the torpedo and pre-cotyledonary stages. These compounds play a central role in the development of somatic embryos of Acca sellowiana.O objetivo deste trabalho foi quantificar os teores de proteína, amido e açúcares totais durante a histodiferenciação e desenvolvimento dos embriões somáticos em Acca sellowiana Berg. Para as observações histológicas, as amostras foram desidratadas em uma bateria de etanol, emblocadas em historesina e coradas com azul de toluidina (morfologia, azul de coomassie (corpos proteicos e reativo ácido periódico de Schiff (amido. As proteínas foram extraídas usando uma solução tampão, precipitadas usando etanol e quantificadas por meio do reativo de Bradford. Os açúcares totais foram extraídos usando uma

  19. Reliability of basal plasma vasopressin concentrations in healthy male adults.

    Science.gov (United States)

    Quintana, Daniel S; Westlye, Lars T; Smerud, Knut T; Mahmoud, Ramy A; Djupesland, Per G; Andreassen, Ole A

    2017-10-01

    The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) play important and interrelated roles in modulating mammalian social behaviour. While the OT system has received considerable research attention for its potential to treat psychiatric symptoms, comparatively little is known about the role of the AVP system in human social behaviour. To better understand the intraindividual stability of basal AVP, the present study assessed the reproducibility of basal plasma AVP concentrations. Basal plasma AVP was assessed at four sampling points separated by 8 days, on average, in 16 healthy adult males. Only one out of six comparisons revealed strong evidence for reproducibility of basal AVP concentrations (visit 2 vs. visit 4: r=0.8, p0.1). The concordance correlation coefficient [0.15, 95% CI (-0.55, 0.73)] also revealed poor overall reproducibility. Poor reliability of basal AVP concentrations suggests future work covarying AVP with trait markers should proceed with careful consideration of intraindividual fluctuations.

  20. Optimering av nanocellulosa för tillämpning som papperstyrkeadditiv

    OpenAIRE

    Englöf, Johan

    2015-01-01

    Syftet med projektet var att undersöka hur homogeniserings förhållanden (tryck antal passager och därmed energiinsatsen) vid framställning av MFC (mikrofibrillär cellulosa), från enzymatiskt förbehandlade pappersmassafibrer påverkar hållfastheten av papper förstärkt med MFC. Arbetsgivaren för projektet var Innventia och det laborativa arbetet har utförts i deras lokaler. Fördelen med att använda MFC som tillsats i papper är att arket blir starkare [1]. Detta medför att en mindre mängd materia...

  1. Musikterapi som bidrag til en tværfaglig og personcentreret demensomsorg

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner

    2015-01-01

    blive belyst i kapitlet og videre anvendt i en argumentation for, at der i omsorgsarbejde med mennesker, som har vanskeligt ved at indgå i fællesskaber pga. en demenssygdom, kan inddrages viden om hvordan netop fællesskab og samvær styrkes af musik. Det indebærer ikke blot viden om, hvad musik er, f...... for overbehandling med antipsykotisk medicin, samt stress og udbrændthed hos de nærmeste omsorgsgivere. Kan vores viden, om hvordan musik kan skabe samvær og er grundlæggende i den menneskelige kommunikation, anvendes i denne sammenhæng? I de nationale retningslinjer for demens anbefaler Sundhedsstyrelsen ’ikke...

  2. Rapport fra VIOL-projektet, Del 2: Technological literacy som udfordring for professioner og uddannelse

    DEFF Research Database (Denmark)

    Rapporten ”Technological literacy som udfordring for professioner og uddannelse” er del af den samlede afrapportering af projektet ”Velfærdsteknologi, Innovation, Omsorg og Læring” (VIOL). VIOL-projektet er gennemført i et samarbejde mellem University College Sjælland (UCSJ) og Roskilde Universitet...... (RUC) og er støttet af Den Europæiske Socialfond. Projektet er gennemført i perioden januar 2013 til og med februar 2015. Rapporten ”Technological literacy - analyser og erfaringsopsamling på tværs af professioner” samler og formidler en tværgående analyse af projektets erfaringer og resultater med...... særligt fokus på analyser og fortolkninger af ”technological literacy” på tværs af professioner og ud-dannelser....

  3. Bearing Condition Recognition and Degradation Assessment under Varying Running Conditions Using NPE and SOM

    Directory of Open Access Journals (Sweden)

    Shaohui Zhang

    2014-01-01

    Full Text Available Manifold learning methods have been widely used in machine condition monitoring and fault diagnosis. However, the results reported in these studies focus on the machine faults under stable loading and rotational speeds, which cannot interpret the practical machine running. Rotating machine is always running under variable speeds and loading, which makes the vibration signal more complicated. To address such concern, the NPE (neighborhood preserving embedding is applied for bearing fault classification. Compared with other algorithms (PCA, LPP, LDA, and ISOP, the NPE performs well in feature extraction. Since the traditional time domain signal denoising is time consuming and memory consuming, we denoise the signal features directly in feature space. Furthermore, NPE and SOM (self-organizing map are combined to assess the bearing degradation performance. Simulation and experiment results validate the effectiveness of the proposed method.

  4. Med ordet som våpen. Husittane og ålmenta

    OpenAIRE

    Øystese, Martin Berland

    2015-01-01

    I denne oppgåva har eg undersøkt korleis husittane såg på ålmenta i Bøhmen tidleg på 1400-talet. Gjennom song, talar og propaganda skapa dei ei ålmente som var særs open for si tid, og skulle stå seg mot fem krosstog send frå den katolske kyrkja. Deira lære skulle endre Bøhmens historie dei neste 200 åra. The Hussite movement occurred in a volatile period. After ending the papal schism in the Catholic Church, the Conciliar Movement searched for ways to again unif...

  5. Characterization of interstitial lung disease in chest radiographs using SOM artificial neural network

    International Nuclear Information System (INIS)

    Azevedo-Marques, P.M. de; Ambrosio, P.E.; Pereira, R.R. Jr.; Valini, R. de A.; Salomao, S.C.

    2007-01-01

    This paper presents an automated approach to apply a self-organizing map (SOM) artificial neural network (ANN) as a tool for feature extraction and dimensionality reduction to recognize and characterize radiologic patterns of interstitial lung diseases in chest radiography. After feature extraction and dimensionality reduction a multilayer perceptron (MLP) ANN is applied for radiologic patterns classification in normal, linear, nodular or mixed. A leave-one-out methodology was applied for training and test over a database containing 17 samples of linear pattern, 9 samples of nodular pattern, 9 samples of mixed pattern and 18 samples of normal pattern. The MLP network provided an average result of 88.7% of right classification, with 100% of right classification for linear pattern, 55.5% for nodular pattern, 77.7% for mixed pattern and 100% for normal pattern. (orig.)

  6. 'De digitale elever' som genstand for ledelse af læring i folkeskolen

    DEFF Research Database (Denmark)

    Stenbøg, Sofie

    2016-01-01

    Mange børn er i dag allerede fra en tidlig alder erfarne teknologibrugere. Denne omstændighed har fået flere folkeskoler til at medtænke elevernes digitale erfaringer og kompetencer fra fritidslivet som centrale ressourcer i undervisningen. Kapitlet undersøger, hvordan ’de digitale elever’ på...... forskellige måder gøres til genstand for ledelse på en skole, der arbejder med at inddrage elevernes digitale erfaringer og kompetencer gennem digitalt projektarbejde. Kapitlet viser, at der knytter sig en lang række kausale antagelser og forhåbninger til de digitale elever, og at disse virker bestemmende...... for både lærerens ledelsesopgave og rollefordelingen mellem lærer og elever i det digitale projektarbejde. Disse antagelser og forhåbninger diskuteres kritisk i lyset af nyere studier af folkeskoleelevers digitale kompetencer....

  7. Segmentation of Natural Gas Customers in Industrial Sector Using Self-Organizing Map (SOM) Method

    Science.gov (United States)

    Masbar Rus, A. M.; Pramudita, R.; Surjandari, I.

    2018-03-01

    The usage of the natural gas which is non-renewable energy, needs to be more efficient. Therefore, customer segmentation becomes necessary to set up a marketing strategy to be right on target or to determine an appropriate fee. This research was conducted at PT PGN using one of data mining method, i.e. Self-Organizing Map (SOM). The clustering process is based on the characteristic of its customers as a reference to create the customer segmentation of natural gas customers. The input variables of this research are variable of area, type of customer, the industrial sector, the average usage, standard deviation of the usage, and the total deviation. As a result, 37 cluster and 9 segment from 838 customer data are formed. These 9 segments then employed to illustrate the general characteristic of the natural gas customer of PT PGN.

  8. Synaptic properties of SOM- and CCK-expressing cells in dentate gyrus interneuron networks.

    Science.gov (United States)

    Savanthrapadian, Shakuntala; Meyer, Thomas; Elgueta, Claudio; Booker, Sam A; Vida, Imre; Bartos, Marlene

    2014-06-11

    Hippocampal GABAergic cells are highly heterogeneous, but the functional significance of this diversity is not fully understood. By using paired recordings of synaptically connected interneurons in slice preparations of the rat and mouse dentate gyrus (DG), we show that morphologically identified interneurons form complex neuronal networks. Synaptic inhibitory interactions exist between cholecystokinin (CCK)-expressing hilar commissural associational path (HICAP) cells and among somatostatin (SOM)-containing hilar perforant path-associated (HIPP) interneurons. Moreover, both interneuron types inhibit parvalbumin (PV)-expressing perisomatic inhibitory basket cells (BCs), whereas BCs and HICAPs rarely target HIPP cells. HICAP and HIPP cells produce slow, weak, and unreliable inhibition onto postsynaptic interneurons. The time course of inhibitory signaling is defined by the identity of the presynaptic and postsynaptic cell. It is the slowest for HIPP-HIPP, intermediately slow for HICAP-HICAP, but fast for BC-BC synapses. GABA release at interneuron-interneuron synapses also shows cell type-specific short-term dynamics, ranging from multiple-pulse facilitation at HICAP-HICAP, biphasic modulation at HIPP-HIPP to depression at BC-BC synapses. Although dendritic inhibition at HICAP-BC and HIPP-BC synapses appears weak and slow, channelrhodopsin 2-mediated excitation of SOM terminals demonstrates that they effectively control the activity of target interneurons. They markedly reduce the discharge probability but sharpen the temporal precision of action potential generation. Thus, dendritic inhibition seems to play an important role in determining the activity pattern of GABAergic interneuron populations and thereby the flow of information through the DG circuitry. Copyright © 2014 the authors 0270-6474/14/348197-13$15.00/0.

  9. Canticum Novum: música sem palavras e palavras sem som no pensamento de Santo Agostinho

    Directory of Open Access Journals (Sweden)

    Lorenzo Mammì

    2000-04-01

    Full Text Available NO De Magistro, Santo Agostinho coloca a reza e o canto numa posição similar, à margem das funções imediatamente comunicativas da linguagem. A reflexão agostiniana sobre a reza se baseia nos hábitos cristãos da leitura, da oração e da meditação silenciosas. Há sobre o canto, na prática igualmente inovadora do jubilus, melodia sem palavra destinada aos momentos mais intensos e gaudiosos da liturgia. A oração silenciosa e o jubilus são temas recorrentes da literatura patrística, mas Agostinho os aborda de maneira original, desenhando, a partir das palavras sem som da oração e do som sem palavra do jubilus, o perfil de um discurso interior, que não se destina aos homens, mas a Deus.IN HIS De Magistro Saint Augustine places prayer and song on a similar level, alongside the language immediately communicative functions. His considerations on prayer are grounded on the Christian habits of silent reading, prayer and meditation; those on song, on the equally innovating practice called jubilus, which is melody without words designed for the intensest and most joyous liturgical moments. Silent prayer and jubilus are recurring topics in patristic literature, but Augustine deals with them in an original way, drawing from the soundless words of prayer and the wordless sound of jubilus an inner discourse, addressed not to men but to God.

  10. Embriogénesis somática en papa cvs. Atlantic y Fritolay-1867

    Directory of Open Access Journals (Sweden)

    M. C. Sánchez-Enciso

    2005-01-01

    Full Text Available El empleo del cultivo in vitro de células y tejidos vegetales para la obtención de embriones somáticos, se considera como un método eficiente para la propagación de un número de especies de importancia agronómica y hortícola, entre las que se encuentra la papa Solanum tuberosum L. El objetivo del presente estudio fue la obtención de células embriogénicas a partir de explantes de mesófilo de hoja de papa cultivares Fritolay-1867 y Atlantic. La formación de embriones somáticos de papa ‘Fritolay-1867’ se promovió cuando en el medio de cultivo se utilizó thidiazuron a una concentración de 1.0 mg·litro-1 como regulador del crecimiento, los cuales se cultivaron en medio que contenía sales de Murashige y Skoog complementados con vitaminas, carbohidratos y antioxidantes, incubándose inicialmente durante ocho semanas en oscuridad y posteriormente durante fotoperíodos de 16 h luz a una intensidad de 44 µmol·s-1·m-2 y a una temperatura de 26±1 °C durante 60 días. A las nueve semanas se obtuvieron los primeros inicios de germinación de los embriones con un 5 %, desarrollando en plantas completas

  11. Axillary basal cell carcinoma in patients with Goltz-Gorlin syndrome: report of basal cell carcinoma in both axilla of a woman with basal cell nevus syndrome and literature review.

    Science.gov (United States)

    Cohen, Philip R

    2014-08-17

    Basal cell carcinoma of the axilla, an area that is not usually exposed to the sun, is rare. Individuals with basal cell nevus syndrome, a disorder associated with a mutation in the patch 1 (PTCH1) gene, develop numerous basal cell carcinomas. To describe a woman with basal cell nevus syndrome who developed a pigmented basal cell carcinoma in each of her axilla and to review the features of axillary basal cell carcinoma patients with Goltz-Gorlin syndrome. Pubmed was used to search the following terms: axillary basal cell carcinoma and basal cell nevus syndrome. The papers and their citations were evaluated. Basal cell nevus syndrome patients with basal cell carcinoma of the axilla were observed in two women; this represents 2.5% (2 of 79) of the patients with axillary basal cell carcinoma. Both women had pigmented tumors that were histologically nonaggressive. The cancers did not recur after curettage or excision. Basal cell carcinoma of the axilla has only been described in 79 individuals; two of the patients were women with pigmented tumors who had basal cell nevus syndrome. Similar to other patients with axillary basal cell carcinoma, the tumors were histologically nonaggressive and did not recur following treatment. Whether PTCH1 gene mutation predisposes basal cell nevus patients to develop axillary basal cell carcinomas remains to be determined.

  12. How ice shelf morphology controls basal melting

    Science.gov (United States)

    Little, Christopher M.; Gnanadesikan, Anand; Oppenheimer, Michael

    2009-12-01

    The response of ice shelf basal melting to climate is a function of ocean temperature, circulation, and mixing in the open ocean and the coupling of this external forcing to the sub-ice shelf circulation. Because slope strongly influences the properties of buoyancy-driven flow near the ice shelf base, ice shelf morphology plays a critical role in linking external, subsurface heat sources to the ice. In this paper, the slope-driven dynamic control of local and area-integrated melting rates is examined under a wide range of ocean temperatures and ice shelf shapes, with an emphasis on smaller, steeper ice shelves. A 3-D numerical ocean model is used to simulate the circulation underneath five idealized ice shelves, forced with subsurface ocean temperatures ranging from -2.0°C to 1.5°C. In the sub-ice shelf mixed layer, three spatially distinct dynamic regimes are present. Entrainment of heat occurs predominately under deeper sections of the ice shelf; local and area-integrated melting rates are most sensitive to changes in slope in this "initiation" region. Some entrained heat is advected upslope and used to melt ice in the "maintenance" region; however, flow convergence in the "outflow" region limits heat loss in flatter portions of the ice shelf. Heat flux to the ice exhibits (1) a spatially nonuniform, superlinear dependence on slope and (2) a shape- and temperature-dependent, internally controlled efficiency. Because the efficiency of heat flux through the mixed layer decreases with increasing ocean temperature, numerical simulations diverge from a simple quadratic scaling law.

  13. Basal melting driven by turbulent thermal convection

    Science.gov (United States)

    Rabbanipour Esfahani, Babak; Hirata, Silvia C.; Berti, Stefano; Calzavarini, Enrico

    2018-05-01

    Melting and, conversely, solidification processes in the presence of convection are key to many geophysical problems. An essential question related to these phenomena concerns the estimation of the (time-evolving) melting rate, which is tightly connected to the turbulent convective dynamics in the bulk of the melt fluid and the heat transfer at the liquid-solid interface. In this work, we consider a convective-melting model, constructed as a generalization of the Rayleigh-Bénard system, accounting for the basal melting of a solid. As the change of phase proceeds, a fluid layer grows at the heated bottom of the system and eventually reaches a turbulent convection state. By means of extensive lattice-Boltzmann numerical simulations employing an enthalpy formulation of the governing equations, we explore the model dynamics in two- and three-dimensional configurations. The focus of the analysis is on the scaling of global quantities like the heat flux and the kinetic energy with the Rayleigh number, as well as on the interface morphology and the effects of space dimensionality. Independently of dimensionality, we find that the convective-melting system behavior shares strong resemblances with that of the Rayleigh-Bénard one, and that the heat flux is only weakly enhanced with respect to that case. Such similarities are understood, at least to some extent, considering the resulting slow motion of the melting front (with respect to the turbulent fluid velocity fluctuations) and its generally little roughness (compared to the height of the fluid layer). Varying the Stefan number, accounting for the thermodynamical properties of the material, also seems to have only a mild effect, which implies the possibility of extrapolating results in numerically delicate low-Stefan setups from more convenient high-Stefan ones. Finally, we discuss the implications of our findings for the geophysically relevant problem of modeling Arctic ice melt ponds.

  14. Basal ganglia - thalamus and the crowning enigma

    Directory of Open Access Journals (Sweden)

    Marianela eGarcia-Munoz

    2015-11-01

    Full Text Available When Hubel (1982 referred to layer 1 of primary visual cortex as …a ‘crowning mystery’ to keep area-17 physiologists busy for years to come... he could have been talking about any cortical area. In the 80’s and 90’s there were no methods to examine this neuropile on the surface of the cortex: a tangled web of axons and dendrites from a variety of different places with unknown specificities and doubtful connections to the cortical output neurons some hundreds of microns below. Recently, three changes have made the crowning enigma less of an impossible mission: the clear presence of neurons in layer 1 (L1, the active conduction of voltage along apical dendrites and optogenetic methods that might allow us to look at one source of input at a time. For all of those reasons alone, it seems it is time to take seriously the function of L1. The functional properties of this layer will need to wait for more experiments but already L1 cells are GAD67 positive, i.e., inhibitory! They could reverse the sign of the thalamic glutamate (GLU input for the entire cortex. It is at least possible that in the near future normal activity of individual sources of L1 could be detected using genetic tools. We are at the outset of important times in the exploration of thalamic functions and perhaps the solution to the crowning enigma is within sight. Our review looks forward to that solution from the solid basis of the anatomy of the basal ganglia output to motor thalamus. We will focus on L1, its afferents, intrinsic neurons and its influence on responses of pyramidal neurons in layers 2/3 and 5. Since L1 is present in the whole cortex we will provide a general overview considering evidence mainly from the somatosensory cortex before focusing on motor cortex.

  15. Serous otitis media (S.O.M.). A bacteriological study of the ear canal and the middle ear

    NARCIS (Netherlands)

    Cabenda, S. I.; Peerbooms, P. G.; van Asselt, G. J.; Feenstra, L.; van der Baan, S.

    1988-01-01

    A bacteriological study of the middle-ear effusions and the ear canals in children with chronic serous otitis media (S.O.M.) was performed. Sixty-eight children (127 ears) were investigated. From this study it appeared that cleansing of the ear canal with 0.5% chlorhexidine in 70% ethanol for 30 s

  16. 'Vi kan rejse og pille lige så godt som de derude.' Kartoffelavlerdansk i det østlige Canada

    DEFF Research Database (Denmark)

    Kühl, Karoline

    2018-01-01

    Citatet i overskriften vil sandsynligvis efterlade læseren i tvivl om hvad denne artikel handler om. Ytringen er nordamerikansk dansk som det tal(t)es i den lille by New Denmark i provinsen New Brunswick i det østlige Canada, og den handler såmænd om kartoffelavl. New Denmark er et enestående eks...

  17. Med fodbold som "hook" - et udviklingsprojekt på tværs af grænser

    DEFF Research Database (Denmark)

    Klausen, Bodil; Greve, Charlotte

    2009-01-01

    Artiklen beskriver et socialt innovationsprojekt som udspringer af et samarbejde mellem de to fodboldklubber: Premier League-fodboldklubben West Ham United fra East London og fodboldklubben AC Horsens & de to uddannelsesinstitutioner: VIA University College, Pædagoguddannelsen i Gedved og Univers...

  18. Grønland som del af den bibelske fortælling - en 1700-tals studie

    DEFF Research Database (Denmark)

    Kjærgaard, Kathrine

    2010-01-01

     For missionærerne i Grønland som for de fleste andre i 1700-tallet var Bibelen en historisk sand fortælling om verden, der omfattede hele verdenshistorien fra Skabelsen til de sidste tider. Bibelen var ikke bare en sand historie om fortiden, den var også en sand historie om nutiden og om fremtid...

  19. Knowledge-based approach for functional MRI analysis by SOM neural network using prior labels from Talairach stereotaxic space

    Science.gov (United States)

    Erberich, Stephan G.; Willmes, Klaus; Thron, Armin; Oberschelp, Walter; Huang, H. K.

    2002-04-01

    Among the methods proposed for the analysis of functional MR we have previously introduced a model-independent analysis based on the self-organizing map (SOM) neural network technique. The SOM neural network can be trained to identify the temporal patterns in voxel time-series of individual functional MRI (fMRI) experiments. The separated classes consist of activation, deactivation and baseline patterns corresponding to the task-paradigm. While the classification capability of the SOM is not only based on the distinctness of the patterns themselves but also on their frequency of occurrence in the training set, a weighting or selection of voxels of interest should be considered prior to the training of the neural network to improve pattern learning. Weighting of interesting voxels by means of autocorrelation or F-test significance levels has been used successfully, but still a large number of baseline voxels is included in the training. The purpose of this approach is to avoid the inclusion of these voxels by using three different levels of segmentation and mapping from Talairach space: (1) voxel partitions at the lobe level, (2) voxel partitions at the gyrus level and (3) voxel partitions at the cell level (Brodmann areas). The results of the SOM classification based on these mapping levels in comparison to training with all brain voxels are presented in this paper.

  20. A Fucking Tragedy - Krimien som vor tids tragedie? Arne Dahls Europa Blues og Jan Arnalds Övervåld

    DEFF Research Database (Denmark)

    Kirkegaard, Peter

    2010-01-01

    Artiklen indkredser historisk det halvt opløste genrebegreb 'tragedie' og diskuterer det i forhold til det mere modstandsdygtige og åbne begreb om det tragiske' som en særskilt modalitet. Det sker i sidste ende for at godtgøre, at også den moderne, avancerede krimi - in casu svenske Arne Dahls Eu...

  1. Florence Nightingale som symbolsk overgangsfigur i lærebøger for sygeplejersker - et lille stykke sygeplejehistorie

    DEFF Research Database (Denmark)

    Jørgensen, Emmy Brandt

    2009-01-01

    Artiklen er et lille indlæg om, hvordan man har anvendt Florence Nightingale i danske lærebøger for sygeplejersker som en legitimeringsfigur i forbindelse med forandringer inden for det danske hospitalsvæsen. Perioden, der behandles, er tiden før og efter skiftet til den kliniske medicin i Danmark...

  2. Using Self-Organizing Map (SOM) Clusters of Ozonesonde Profiles to Evaluate Climatologies and Create Linkages between Meteorology and Pollution

    Science.gov (United States)

    Stauffer, R. M.; Thompson, A. M.; Young, G. S.; Oltmans, S. J.; Johnson, B.

    2016-12-01

    Ozone (O3) climatologies are typically created by averaging ozonesonde profiles on a monthly or seasonal basis, either for specific regions or zonally. We demonstrate the advantages of using a statistical clustering technique, self-organizing maps (SOM), over this simple averaging, through analysis of more than 4500 sonde profiles taken from the long-term US sites at Boulder, CO; Huntsville, AL; Trinidad Head, CA; and Wallops Island, VA. First, we apply SOM to O3 mixing ratios from surface to 12 km amsl. At all four sites, profiles in SOM clusters exhibit similar tropopause height, 500 hPa height and temperature, and total and tropospheric column O3. Second, when profiles from each SOM cluster are compared to monthly O3 means, near-tropopause O3 in three of the clusters is double (over +100 ppbv) the climatological O3 mixing ratio. The three clusters include 13-16% of all profiles, mostly from winter and spring. Large mid-tropospheric deviations from monthly means are found in two highly-populated clusters that represent either distinctly polluted (summer) or clean O3 (fall-winter, high tropopause) profiles. Thus, SOM indeed appear to represent US O3 profile statistics better than conventional climatologies. In the case of Trinidad Head, SOM clusters of O3 profile data from the lower troposphere (surface-6 km amsl) can discriminate background vs polluted O3 and the meteorology associated with each. Two of nine O3 clusters exhibit thin layers ( 100s of m thick) of high O3, typically between 1 and 4 km. Comparisons between clusters and downwind, high-altitude surface O3 measurements display a marked impact of the elevated tropospheric O­­3. Days corresponding to the high O3 clusters exhibit hourly surface O3 anomalies at surface sites of +5 -10 ppbv compared to a climatology; the anomalies can last up to four days. We also explore applications of SOM to tropical ozonesonde profiles, where tropospheric O3 variability is generally smaller.

  3. Impact of Fe(III)-OM complexes and Fe(III) polymerization on SOM pools reactivity under different land uses

    Science.gov (United States)

    Giannetta, B.; Plaza, C.; Zaccone, C.; Siebecker, M. G.; Rovira, P.; Vischetti, C.; Sparks, D. L.

    2017-12-01

    Soil organic matter (SOM) protection and long-term accumulation are controlled by adsorption to mineral surfaces in different ways, depending on its molecular structure and pedo-climatic conditions. Iron (Fe) oxides are known to be key regulators of the soil carbon (C) cycle, and Fe speciation in soils is highly dependent on environmental conditions and chemical interactions with SOM. However, the molecular structure and hydrolysis of Fe species formed in association with SOM is still poorly described. We hypothesize the existence of two pools of Fe which interact with SOM: mononuclear Fe(III)-SOM complexes and precipitated Fe(III) hydroxides. To verify our hypothesis, we investigated the interactions between Fe(III) and physically isolated soil fractions by means of batch experiments at pH 7. Specifically, we examined the fine silt plus clay (FSi+C) fraction, obtained by ultrasonic dispersion and wet sieving. The soil samples spanned several land uses, including coniferous forest (CFS), grassland (GS), technosols (TS) and agricultural (AS) soils. Solid phase products and supernatants were analyzed for C and Fe content. X-ray diffraction (XRD) and Brunauer-Emmett-Teller (BET) analysis were also performed. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) was used to assess the main C functional groups involved in C complexation and desorption experiments. Preliminary linear combination fitting (LCF) of Fe K-edge extended X-ray absorption fine structure (EXAFS) spectra suggested the formation of ferrihydrite-like polymeric Fe(III) oxides in reacted CFS and GS samples, with higher C and Fe concentration. Conversely, mononuclear Fe(III) OM complexes dominated the speciation for TS and AS samples, characterized by lower C and Fe concentration, inhibiting the hydrolysis and polymerization of Fe (III). This approach will help revealing the mechanisms by which SOM pools can control Fe(III) speciation, and will elucidate how both Fe

  4. Implications of basal micro-earthquakes and tremor for ice stream mechanics: Stick-slip basal sliding and till erosion

    Science.gov (United States)

    Barcheck, C. Grace; Tulaczyk, Slawek; Schwartz, Susan Y.; Walter, Jacob I.; Winberry, J. Paul

    2018-03-01

    The Whillans Ice Plain (WIP) is unique among Antarctic ice streams because it moves by stick-slip. The conditions allowing stick-slip and its importance in controlling ice dynamics remain uncertain. Local basal seismicity previously observed during unstable slip is a clue to the mechanism of ice stream stick-slip and a window into current basal conditions, but the spatial extent and importance of this basal seismicity are unknown. We analyze data from a 2010-2011 ice-plain-wide seismic and GPS network to show that basal micro-seismicity correlates with large-scale patterns in ice stream slip behavior: Basal seismicity is common where the ice moves the least between unstable slip events, with small discrete basal micro-earthquakes happening within 10s of km of the central stick-slip nucleation area and emergent basal tremor occurring downstream of this area. Basal seismicity is largely absent in surrounding areas, where inter-slip creep rates are high. The large seismically active area suggests that a frictional sliding law that can accommodate stick-slip may be appropriate for ice stream beds on regional scales. Variability in seismic behavior over inter-station distances of 1-10 km indicates heterogeneity in local bed conditions and frictional complexity. WIP unstable slips may nucleate when stick-slip basal earthquake patches fail over a large area. We present a conceptual model in which basal seismicity results from slip-weakening frictional failure of over-consolidated till as it is eroded and mobilized into deforming till.

  5. A basal stem cell signature identifies aggressive prostate cancer phenotypes

    Science.gov (United States)

    Smith, Bryan A.; Sokolov, Artem; Uzunangelov, Vladislav; Baertsch, Robert; Newton, Yulia; Graim, Kiley; Mathis, Colleen; Cheng, Donghui; Stuart, Joshua M.; Witte, Owen N.

    2015-01-01

    Evidence from numerous cancers suggests that increased aggressiveness is accompanied by up-regulation of signaling pathways and acquisition of properties common to stem cells. It is unclear if different subtypes of late-stage cancer vary in stemness properties and whether or not these subtypes are transcriptionally similar to normal tissue stem cells. We report a gene signature specific for human prostate basal cells that is differentially enriched in various phenotypes of late-stage metastatic prostate cancer. We FACS-purified and transcriptionally profiled basal and luminal epithelial populations from the benign and cancerous regions of primary human prostates. High-throughput RNA sequencing showed the basal population to be defined by genes associated with stem cell signaling programs and invasiveness. Application of a 91-gene basal signature to gene expression datasets from patients with organ-confined or hormone-refractory metastatic prostate cancer revealed that metastatic small cell neuroendocrine carcinoma was molecularly more stem-like than either metastatic adenocarcinoma or organ-confined adenocarcinoma. Bioinformatic analysis of the basal cell and two human small cell gene signatures identified a set of E2F target genes common between prostate small cell neuroendocrine carcinoma and primary prostate basal cells. Taken together, our data suggest that aggressive prostate cancer shares a conserved transcriptional program with normal adult prostate basal stem cells. PMID:26460041

  6. Learning and memory functions of the Basal Ganglia.

    Science.gov (United States)

    Packard, Mark G; Knowlton, Barbara J

    2002-01-01

    Although the mammalian basal ganglia have long been implicated in motor behavior, it is generally recognized that the behavioral functions of this subcortical group of structures are not exclusively motoric in nature. Extensive evidence now indicates a role for the basal ganglia, in particular the dorsal striatum, in learning and memory. One prominent hypothesis is that this brain region mediates a form of learning in which stimulus-response (S-R) associations or habits are incrementally acquired. Support for this hypothesis is provided by numerous neurobehavioral studies in different mammalian species, including rats, monkeys, and humans. In rats and monkeys, localized brain lesion and pharmacological approaches have been used to examine the role of the basal ganglia in S-R learning. In humans, study of patients with neurodegenerative diseases that compromise the basal ganglia, as well as research using brain neuroimaging techniques, also provide evidence of a role for the basal ganglia in habit learning. Several of these studies have dissociated the role of the basal ganglia in S-R learning from those of a cognitive or declarative medial temporal lobe memory system that includes the hippocampus as a primary component. Evidence suggests that during learning, basal ganglia and medial temporal lobe memory systems are activated simultaneously and that in some learning situations competitive interference exists between these two systems.

  7. Red Dot Basal Cell Carcinoma: Report of Cases and Review of This Unique Presentation of Basal Cell Carcinoma.

    Science.gov (United States)

    Cohen, Philip R

    2017-03-22

    Red dot basal cell carcinoma is a unique variant of basal cell carcinoma. Including the three patients described in this report, red dot basal cell carcinoma has only been described in seven individuals. This paper describes the features of two males and one female with red dot basal cell carcinoma and reviews the characteristics of other patients with this clinical subtype of basal cell carcinoma. A 70-year-old male developed a pearly-colored papule with a red dot in the center on his nasal tip. A 71-year-old male developed a red dot surrounded by a flesh-colored papule on his left nostril. Lastly, a 74-year-old female developed a red dot within an area of erythema on her left mid back. Biopsy of the lesions all showed nodular and/or superficial basal cell carcinoma. Correlation of the clinical presentation and pathology established the diagnosis of red dot basal cell carcinoma. The tumors were treated by excision using the Mohs surgical technique. Pubmed was searched with the keyword: basal, cell, cancer, carcinoma, dot, red, and skin. The papers generated by the search and their references were reviewed. Red dot basal cell carcinoma has been described in three females and two males; the gender was not reported in two patients. The tumor was located on the nose (five patients), back (one patient) and thigh (one patient). Cancer presented as a solitary small red macule or papule; often, the carcinoma was surrounded by erythema or a flesh-colored papule. Although basal cell carcinomas usually do not blanch after a glass microscope slide is pressed against them, the red dot basal cell carcinoma blanched after diascopy in two of the patients, resulting in a delay of diagnosis in one of these individuals. Dermoscopy may be a useful non-invasive modality for evaluating skin lesions when the diagnosis of red dot basal cell carcinoma is considered. Mohs surgery is the treatment of choice; in some of the patients, the ratio of the area of the postoperative wound to that

  8. The expanding universe of disorders of the basal ganglia.

    Science.gov (United States)

    Obeso, Jose A; Rodriguez-Oroz, Maria C; Stamelou, Maria; Bhatia, Kailash P; Burn, David J

    2014-08-09

    The basal ganglia were originally thought to be associated purely with motor control. However, dysfunction and pathology of different regions and circuits are now known to give rise to many clinical manifestations beyond the association of basal ganglia dysfunction with movement disorders. Moreover, disorders that were thought to be caused by dysfunction of the basal ganglia only, such as Parkinson's disease and Huntington's disease, have diverse abnormalities distributed not only in the brain but also in the peripheral and autonomic nervous systems; this knowledge poses new questions and challenges. We discuss advances and the unanswered questions, and ways in which progress might be made. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Evaluation of <em>HER2em> Gene Amplification in Breast Cancer Using Nuclei Microarray <em>in em>S>itu em>Hybridization

    Directory of Open Access Journals (Sweden)

    Xuefeng Zhang

    2012-05-01

    Full Text Available Fluorescence<em> em>>in situ em>hybridization (FISH assay is considered the “gold standard” in evaluating <em>HER2/neu (HER2em> gene status. However, FISH detection is costly and time consuming. Thus, we established nuclei microarray with extracted intact nuclei from paraffin embedded breast cancer tissues for FISH detection. The nuclei microarray FISH (NMFISH technology serves as a useful platform for analyzing <em>HER2em> gene/chromosome 17 centromere ratio. We examined <em>HER2em> gene status in 152 cases of invasive ductal carcinomas of the breast that were resected surgically with FISH and NMFISH. <em>HER2em> gene amplification status was classified according to the guidelines of the American Society of Clinical Oncology and College of American Pathologists (ASCO/CAP. Comparison of the cut-off values for <em>HER2em>/chromosome 17 centromere copy number ratio obtained by NMFISH and FISH showed that there was almost perfect agreement between the two methods (κ coefficient 0.920. The results of the two methods were almost consistent for the evaluation of <em>HER2em> gene counts. The present study proved that NMFISH is comparable with FISH for evaluating <em>HER2em> gene status. The use of nuclei microarray technology is highly efficient, time and reagent conserving and inexpensive.

  10. Un lettore rozzo dell'Ur-<em>Novellino>

    DEFF Research Database (Denmark)

    Toftgaard, Anders

    2007-01-01

    Håndskriftet Panciatichi 32 fra Nationalbiblioteket i Firenze, den ældste og vigtigste tekstkilde til 'Il Novellino', indeholder nogle tegn i margenen, som hidtil er blevet set som tilfældige tegn på tekstens modtagelsen blandt lokale handelsmænd. Det vises derimod her, hvordan tegnene ikke stammer...

  11. A New Natural Lactone from <em>Dimocarpus> <em>longan> Lour. Seeds

    Directory of Open Access Journals (Sweden)

    Zhongjun Li

    2012-08-01

    Full Text Available A new natural product named longanlactone was isolated from <em>Dimocarpus> <em>longan> Lour. seeds. Its structure was determined as 3-(2-acetyl-1<em>H>-pyrrol-1-yl-5-(prop-2-yn-1-yldihydrofuran-2(3H-one by spectroscopic methods and HRESIMS.

  12. Luhmanns masmedieteori och Internet som ett artificiellt intelligent semiotiskt system Luhmanns massmedieteori och Internet som ett artificiellt intelligent semiotiskt system [Luhmann’s mass-media theory and Internet as an artificial intelligent semiotic system

    Directory of Open Access Journals (Sweden)

    Peter Kåhre

    2010-11-01

    Full Text Available Artikeln diskuterar hur en modern form av AI-programmering, som kallas Konnektionism i en design som kallas Distribuerad AI (DAI, påverkar den uppfattning Luhmann har om massmediernas roll för den andra ordningens observationer. DAI använder noder för att skapa aktivitet i systemen och inte de koder som styr processerna i den klassiska eller symboliska formen av AI. Luhmanns teori kan utvecklas genom att ersätta systemens koder med noder som förändras beroende på i vilken relation de står till andra noder. På så sätt kan kommunikationsbegreppet utvecklas så att det också omfattar systemens interaktioner med omvärlden. Det skapar en bättre förutsättning för att observationsmöjligheter direkt uppstår genom systemens relationer till omvärlden. Internet och AI-programmerade söksystem och robotar kan då fungera som ett artificiellt semiotiskt system som skapar möjligheter att göra observationer.The article discusses how a modern form of AI programming, known as Connectionism in a design known as Distributed Artificial Intelligence (DAI, affects the perception Luhmann has on mass media's role concerning second-order observations. DAI uses nodes to create activity in the systems and not the codes used by the Classic or Symbolic form of AI. Luhmann’s theory can be developed by replacing the systems codes with nodes that change depending on their relations to other nodes. In this way, we can reformulate the concept of communication, so that it includes the systems interactions with the environment. It creates better conditions so that observing opportunities may arise directly from these interactions. Internet and AI-programmed search systems and robots can then act as an artificial semiotic system that creates opportunities for making observations.

  13. Basal ganglia calcification on computed tomography in systemic lupus erythematosus

    International Nuclear Information System (INIS)

    Nagaoka, Shohei; Tani, Kenji; Ishigatsubo, Yoshiaki

    1988-01-01

    The development of basal ganglia calcification was studied in 85 patients with systemic lupus erythematosus (SLE) by computed tomography (CT). Bilateral calcification of the basal ganglia was found to occur in 5 patients (5.9 %) with SLE, but was not seen in patients with rheumatoid arthritis and progressive systemic sclerosis. All were female with a mean age of 42 years (range 29 - 49). The patients with calcification of the basal ganglia had neurological symptoms, such as psychiatric problems (3 cases), grand mal seizures (1 case), CSF abnormalities (2 cases), and EEG changes (4 cases). There were significantly higher incidences of alopecia, cutaneous vasculitis, leukopenia, and thrombocytopenia in the group with calcifications than those in the group with normal CT findings. Circulating immune complexes were detected and LE tests were positive in 2 patients. Endocrinological examination showed no abnormality in any. We suggest that basal ganglia calcification in SLE might be related to cerebral vasculitis. (author)

  14. Airway Basal Cell Heterogeneity and Lung Squamous Cell Carcinoma.

    Science.gov (United States)

    Hynds, Robert E; Janes, Sam M

    2017-09-01

    Basal cells are stem/progenitor cells that maintain airway homeostasis, enact repair following epithelial injury, and are a candidate cell-of-origin for lung squamous cell carcinoma. Heterogeneity of basal cells is recognized in terms of gene expression and differentiation capacity. In this Issue, Pagano and colleagues isolate a subset of immortalized basal cells that are characterized by high motility, suggesting that they might also be heterogeneous in their biophysical properties. Motility-selected cells displayed an increased ability to colonize the lung in vivo The possible implications of these findings are discussed in terms of basal cell heterogeneity, epithelial cell migration, and modeling of metastasis that occurs early in cancer evolution. Cancer Prev Res; 10(9); 491-3. ©2017 AACR See related article by Pagano et al., p. 514 . ©2017 American Association for Cancer Research.

  15. Facial skin follllicular hyperkeratosis of patients with basal cell carcinoma

    Directory of Open Access Journals (Sweden)

    M. V. Zhuchkov

    2016-01-01

    Full Text Available This article provides a clinical observation of paraneoplastic syndrome of a patient with basal cell carcinoma of skin. Authors present clinical features of the described for the first time, paraneoplastic retentional follicular hyperkeratosis of facial area.

  16. Computed tomography of calcification of the basal ganglia

    International Nuclear Information System (INIS)

    Park, Churl Min; Suh, Soo Jhi; Kim, Soon Yong

    1981-01-01

    Calcifications of the basal ganglia are rarely found at routine autopsies and in skull radiographs. CT is superior to the plain skull radiographs in detecting intracranial attenuation differences and may be stated to be the method of choice in the diagnosis of intracranial calcifications. Of 5985 brain CT scans performed in Kyung Hee University Hospital during past 3 years, 36 cases were found to have high attenuation lesions suggesting calcifications within basal ganglia. 1. The incidence of basal ganglia calcification on CT scan was about 0.6%. 2. Of these 36 cases, 34 cases were bilateral and the remainder was unilateral. 3. The plain skull films of 23 cases showed visible calcification of basal ganglia in 3 cases (13%). 4. No specific metabolic disease was noted in the cases

  17. The Basal Cell Marker p63 and Prostate Stem Cells

    National Research Council Canada - National Science Library

    Signoretti, Sabina

    2002-01-01

    ...(s) involved in prostate carcinogenesis. The p53-homologue p63 is selectively expressed in the basal cell compartment of a variety of epithelial tissues and p63 deficient mice show severe defects in the development of epithelial organs...

  18. The Basal Cell Marker p63 and Prostate Stem Cells

    National Research Council Canada - National Science Library

    Signoretti, Sabina

    2003-01-01

    ...(s) involved in prostate carcinogenesis. The p53-homologue p63 is selectively expressed in the basal cell compartment of a variety of epithelial tissues and p63 deficient mice show severe defects in the development of epithelial organs...

  19. The Basal Cell Marker p63 and Prostate Stem Cells

    National Research Council Canada - National Science Library

    Signoretti, Sabina

    2004-01-01

    ...(s) involved in prostate carcinogenesis. The p53-homologue p63 is selectively expressed in the basal cell compartment of a variety of epithelial tissues and p63 deficient mice show severe defects in the development of epithelial organs...

  20. Basal ganglia calcification on computed tomography in systemic lupus erythematosus

    Energy Technology Data Exchange (ETDEWEB)

    Nagaoka, Shohei; Tani, Kenji; Ishigatsubo, Yoshiaki and others

    1988-09-01

    The development of basal ganglia calcification was studied in 85 patients with systemic lupus erythematosus (SLE) by computed tomography (CT). Bilateral calcification of the basal ganglia was found to occur in 5 patients (5.9 %) with SLE, but was not seen in patients with rheumatoid arthritis and progressive systemic sclerosis. All were female with a mean age of 42 years (range 29 - 49). The patients with calcification of the basal ganglia had neurological symptoms, such as psychiatric problems (3 cases), grand mal seizures (1 case), CSF abnormalities (2 cases), and EEG changes (4 cases). There were significantly higher incidences of alopecia, cutaneous vasculitis, leukopenia, and thrombocytopenia in the group with calcifications than those in the group with normal CT findings. Circulating immune complexes were detected and LE tests were positive in 2 patients. Endocrinological examination showed no abnormality in any. We suggest that basal ganglia calcification in SLE might be related to cerebral vasculitis.

  1. [Basal cell carcinoma of the nose].

    Science.gov (United States)

    Bonvallot, T; Raulo, Y; Zeller, J; Faivre, J M; Horn, G; Baruch, J

    1993-01-01

    The purpose of this study of 81 patients with basal cell carcinoma (BCC) of the nose was to present the oncological and cosmetic results of surgical treatment and compare these results with those of other possible treatments. We report a series of 81 cases of histologically proven BCC of the nose located chiefly on the alae nasi and on the lower end of this organ; 42 p. 100 of the tumors had previously been treated and had recurred. The patients' mean age was 63 years, and the shortest follow-up was 3 years. Excision of the tumor under simple or reinforced local anaesthesia was complete in 88 p. 100 of the cases, incomplete or borderline in 12 p. 100 and systematically repeated. Extemporaneous histological examination was performed in 18 p. 100 of the cases. The operative lesion was repaired with a graft or a flap. There was no postsurgical treatment. The recurrence rate was 4 p. 100 with a minimum follow-up of 3 years. The cosmetic result was good in 78 p. 100 of the patients. Numerous treatments have been used against BCC of the nose, the results, advantages and disadvantages of each of these treatments are given below: 1. Cryosurgery. The problem with this method is that it is relatively difficult to perform and requires reliable operators. The cure rate is similar to that of other treatments. 2. Chemotherapy is not frequently used. 3. Electrocoagulation. Contrary to the conventional excision, this method precludes all histological controls, and the common idea of good oncological results is now being revised. 4. Radiotherapy. The recurrence rate varies from 7 to 11.8 p. 100 with fair cosmetic results. It requires numerous sessions, cannot be repeated in case of recurrence and complicates the surgical treatment. In addition, there is a long-term risk of radiodystrophy. 5. Curietherapy by local implantation of 192Iridium has a recurrence rate of 2.5 to 7 p. 100. This treatment requires hospitalization and is costly. It is indicated in cases of complex surgery

  2. Reference Gene Selection in the Desert Plant <em>Eremosparton songoricuem>m>

    Directory of Open Access Journals (Sweden)

    Dao-Yuan Zhang

    2012-06-01

    Full Text Available <em>Eremosparton songoricum em>(Litv. Vass. (<em>E. songoricumem> is a rare and extremely drought-tolerant desert plant that holds promise as a model organism for the identification of genes associated with water deficit stress. Here, we cloned and evaluated the expression of eight candidate reference genes using quantitative real-time reverse transcriptase polymerase chain reactions. The expression of these candidate reference genes was analyzed in a diverse set of 20 samples including various <em>E. songoricumem> plant tissues exposed to multiple environmental stresses. GeNorm analysis indicated that expression stability varied between the reference genes in the different experimental conditions, but the two most stable reference genes were sufficient for normalization in most conditions.<em> EsEFem> and <em>Esα-TUB> were sufficient for various stress conditions, <em>EsEF> and <em>EsACT> were suitable for samples of differing germination stages, and <em>EsGAPDH>and <em>Es>UBQ em>were most stable across multiple adult tissue samples. The <em>Es18Sem> gene was unsuitable as a reference gene in our analysis. In addition, the expression level of the drought-stress related transcription factor <em>EsDREB2em>> em>verified the utility of<em> E. songoricumem> reference genes and indicated that no single gene was adequate for normalization on its own. This is the first systematic report on the selection of reference genes in <em>E. songoricumem>, and these data will facilitate future work on gene expression in this species.

  3. Idiopathic Basal Ganglia Calcification Presented with Impulse Control Disorder

    OpenAIRE

    Sahin, Cem; Levent, Mustafa; Akbaba, Gulhan; Kara, Bilge; Yeniceri, Emine Nese; Inanc, Betul Battaloglu

    2015-01-01

    Primary familial brain calcification (PFBC), also referred to as Idiopathic Basal Ganglia Calcification (IBGC) or “Fahr’s disease,” is a clinical condition characterized by symmetric and bilateral calcification of globus pallidus and also basal ganglions, cerebellar nuclei, and other deep cortical structures. It could be accompanied by parathyroid disorder and other metabolic disturbances. The clinical features are dysfunction of the calcified anatomic localization. IBGC most commonly present...

  4. Nevoid basal cell carcinoma syndrome; Naevoid Basalzellkarzinom-Syndrom

    Energy Technology Data Exchange (ETDEWEB)

    Grgic, A.; Heinrich, M.; Heckmann, M.; Kramann, B. [Universitaetsklinikum des Saarlandes, Homburg/Saar (Germany). Abt. fuer Diagnostische und Interventionelle Radiologie; Aliani, S. [Universitaetsklinikum des Saarlandes, Homburg/Saar (Germany). Klinik fuer Kinder- und Jugendmedizin; Dill-Mueller, D. [Universitaetsklinikum des Saarlandes, Homburg/Saar (Germany). Hautklinik und Poliklinik; Uder, M. [Erlange-Nuernberg Univ. (Germany). Inst. fuer Diagnostische Radiologie

    2005-07-01

    Nevoid Basal Cell Carcinoma Syndrome (NBCCS) is an autosomal-dominant disorder characterized by multiple basal cell carcinomas, jaw cysts, palmar/plantar pits, calcification of the falx cerebri, and spine and rib anomalies. The combination of clinical, imaging, and histological findings is helpful in identifying NBCCS patients. Imaging plays a crucial role in evaluation of these patients. We present a wide variety of clinical and radiological findings characteristic of this disease. (orig.)

  5. Bilateral basal ganglia calcifications visualised on CT scan.

    OpenAIRE

    Brannan, T S; Burger, A A; Chaudhary, M Y

    1980-01-01

    Thirty-eight cases of basal ganglia calcification imaged on computed axial tomography were reviewed. Most cases were felt to represent senescent calcification. The possibility of a vascular aetiology in this group is discussed. A less common group of patients was identified with calcification secondary to abnormalities in calcium metabolism or radiation therapy. Three cases of basal ganglia calcifications were detected in juvenile epileptic patients receiving chronic anticonvulsants. These ca...

  6. Treatment of basal cell epithelioma with high energy electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Ogawa, Y. (Hyogo-ken Cancer Center, Kobe (Japan)); Kumano, M.; Kumano, K.

    1981-11-01

    Thirty patients with basal cell epithelioma received high energy electron beam therapy. They were irradiated with a dose ranging from 4,800 rad (24 fractions, 35 days) to 12,000 rad (40 fractions, 57 days). Tumors disappeared in all cases. These were no disease-related deaths; in one patient there was recurrence after 2 years. We conclude that radiotherapy with high energy electron beam is very effective in the treatment of basal cell epithelioma.

  7. Basal Ganglia Calcification with Tetanic Seizure Suggest Mitochondrial Disorder

    OpenAIRE

    Finsterer, Josef; Enzelsberger, Barbara; Bastowansky, Adam

    2017-01-01

    Patient: Female, 65 Final Diagnosis: Mitochondrial disorder Symptoms: Headache ? tetanic seizure Medication: Diazepam Clinical Procedure: Admission Specialty: Neurology Objective: Challenging differential diagnosis Background: Basal ganglia calcification (BGC) is a rare sporadic or hereditary central nervous system (CNS) abnormality, characterized by symmetric or asymmetric calcification of the basal ganglia. Case Report: We report the case of a 65-year-old Gypsy female who was admitted for a...

  8. Shell bone histology indicates terrestrial palaeoecology of basal turtles

    OpenAIRE

    Scheyer, Torsten; Sander, P. Martin

    2009-01-01

    The palaeoecology of basal turtles from the Late Triassic was classically viewed as being semi-aquatic, similar to the lifestyle of modern snapping turtles. Lately, this view was questioned based on limb bone proportions, and a terrestrial palaeoecology was suggested for the turtle stem. Here, we present independent shell bone microstructural evidence for a terrestrial habitat of the oldest and basal most well-known turtles, i.e. the Upper Triassic Proterochersis robusta and Proganochelys que...

  9. Chemical characterization of soil organic matter in a Chesapeake Bay salt marsh: analyzing microbial and vegetation inputs to SOM

    Science.gov (United States)

    Bye, E.; Schreiner, K. M.; Abdulla, H. A.; Minor, E. C.; Guntenspergen, G. R.

    2017-12-01

    Coastal wetlands play a critical role in the global carbon cycle. These ecosystems sequester and store carbon, known as "blue carbon," at a rate two or three orders of magnitude larger than other terrestrial ecosystems, such as temperate, tropical, and boreal forests. Anthropogenic changes to the climate are threatening blue carbon stores in coastal wetland ecosystems. To understand and predict how these important carbon stores will be affected by anthropogenic climate changes, it is necessary to understand the formation and preservation of soil organic matter (SOM) in these ecosystems. This study will present organic geochemical data from two sediment cores collected from the Smithsonian Environmental Research Center site on a salt marsh in Maryland along the Chesapeake Bay. One core is from a location that recently transitioned from a C4 to C3 plant regime, currently dominated by the sedge Shoenplectis americanus. The second core is from a C4 plant (Spartina patens) dominated location in the marsh. The organic geochemistry of these 100 cm deep sediment cores was studied through multiple bulk analyses including stable isotopes, elemental ratios, Fourier-transform infrared spectroscopy (FTIR), solid-state magic-angle-spinning Nuclear Magnetic Resonance (NMR), and compound specific lignin-phenol analysis. By using comprehensive chemical characterization techniques, this study aims to discern between vegetation- and microbially-derived inputs to SOM in blue carbon ecosystems. The results show a general increase in the aromatic content with a concomitant decrease of carbohydrates with depth in both cores. However, substantial differences between the two cores, indicates differing inputs and/or stabilization mechanisms within SOM formed from different vegetation regimes. Further compound specific work will help to elucidate the specific source of compounds within each compound class, in surface and deep SOM, and additionally can help provide evidence for different

  10. Basal Forebrain Gating by Somatostatin Neurons Drives Prefrontal Cortical Activity.

    Science.gov (United States)

    Espinosa, Nelson; Alonso, Alejandra; Morales, Cristian; Espinosa, Pedro; Chávez, Andrés E; Fuentealba, Pablo

    2017-11-17

    The basal forebrain provides modulatory input to the cortex regulating brain states and cognitive processing. Somatostatin-expressing neurons constitute a heterogeneous GABAergic population known to functionally inhibit basal forebrain cortically projecting cells thus favoring sleep and cortical synchronization. However, it remains unclear if somatostatin cells can regulate population activity patterns in the basal forebrain and modulate cortical dynamics. Here, we demonstrate that somatostatin neurons regulate the corticopetal synaptic output of the basal forebrain impinging on cortical activity and behavior. Optogenetic inactivation of somatostatin neurons in vivo rapidly modified neural activity in the basal forebrain, with the consequent enhancement and desynchronization of activity in the prefrontal cortex, reflected in both neuronal spiking and network oscillations. Cortical activation was partially dependent on cholinergic transmission, suppressing slow waves and potentiating gamma oscillations. In addition, recruitment dynamics was cell type-specific, with interneurons showing similar temporal profiles, but stronger responses than pyramidal cells. Finally, optogenetic stimulation of quiescent animals during resting periods prompted locomotor activity, suggesting generalized cortical activation and increased arousal. Altogether, we provide physiological and behavioral evidence indicating that somatostatin neurons are pivotal in gating the synaptic output of the basal forebrain, thus indirectly controlling cortical operations via both cholinergic and non-cholinergic mechanisms. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  11. CT and MRI diagnosis of traumatic basal ganglia hemorrhage

    International Nuclear Information System (INIS)

    Wu Shike; Zhang Yalin; Xu Derong; Zou Gaowei; Chen Dan; He Sujun; Zhou Lichao

    2009-01-01

    Objective: To analyze CT and MRI features of traumatic basal ganglia hemorrhage and investigate the diagnostic value. Methods: 21 cases with traumatic basal ganglia hemorrhage diagnosed by clinic, CT and MRI in our hospital were collected in this study Plain CT scan were immediately performed in 21 cases after injury, plain MR scan were performed in 1 to 3 days. 12 cases of them underwent diffusion weighted imagine (DWI). The CT and MRI findings were retrospectively summarized. Results: 8 cases were found with simple traumatic basal ganglia hemorrhage. Complexity of basal ganglia hemorrhage occurred in 13 cases, 6 cases combined with subdural hemorrhage, 3 cases with epidural hematoma, 2 cases with subarachnoid hemorrhage, 6 cases with brain contusion and laceration in other locations, 4 cases with skull fracture. 26 lesions of basal ganglia hematoma were showed in 21 cases, 14 lesions of pallidum hemorrhage in 11 cases confirmed by MR could not be distinguished from calcification at the fast CT scan. 5 more lesions of brain contusion and laceration and 4 more lesions of brain white matter laceration were found by MR. Conclusion: CT in combination with MRI can diagnose traumatic basal ganglia hemorrhage and its complications early, comprehensively and accurately, which plays an important role in the clinical therapy selection and prognosis evaluation. (authors)

  12. Thermal history regulates methylbutenol basal emission rate in Pinus ponderosa.

    Science.gov (United States)

    Gray, Dennis W; Goldstein, Allen H; Lerdau, Manuel T

    2006-07-01

    Methylbutenol (MBO) is a 5-carbon alcohol that is emitted by many pines in western North America, which may have important impacts on the tropospheric chemistry of this region. In this study, we document seasonal changes in basal MBO emission rates and test several models predicting these changes based on thermal history. These models represent extensions of the ISO G93 model that add a correction factor C(basal), allowing MBO basal emission rates to change as a function of thermal history. These models also allow the calculation of a new emission parameter E(standard30), which represents the inherent capacity of a plant to produce MBO, independent of current or past environmental conditions. Most single-component models exhibited large departures in early and late season, and predicted day-to-day changes in basal emission rate with temporal offsets of up to 3 d relative to measured basal emission rates. Adding a second variable describing thermal history at a longer time scale improved early and late season model performance while retaining the day-to-day performance of the parent single-component model. Out of the models tested, the T(amb),T(max7) model exhibited the best combination of day-to-day and seasonal predictions of basal MBO emission rates.

  13. Arbejdsmiljøseminarer som et redskab til at skabe motivation, ansvarlighed og ejerskab til arbejdet omkring forebyggelse af ulykker i små-, mellemstore og store virksomheder, såvel blandt ansatte som deres ledere

    DEFF Research Database (Denmark)

    Pedersen, Louise; Kines, Pete

    2009-01-01

    af arbejdsulykker. Vellykkede arbejdsmiljøseminarer kan være en metode til skabe motivation, ansvarlighed og ejerskab samt at mindske den modstand, der kan være imod forandringerne. Med andre ord at arbejde med nogle af de processer, som kan være svære at få indblik i og overskud til at arbejde med i...

  14. Nível de ruídos em uma unidade de cuidados intensivos pediátricos Noise level in a pediatric intensive care unit

    Directory of Open Access Journals (Sweden)

    Werther B. Carvalho

    2005-12-01

    Full Text Available OBJETIVO: Verificar o nível de ruídos em uma unidade de cuidados intensivos pediátricos. MÉTODOS: Estudo observacional e prospectivo realizado em uma unidade de cuidados intensivos pediátricos de 10 leitos de um hospital universitário da cidade de São Paulo, Brasil. Os níveis de ruídos foram medidos por meio de equipamento instalado no corredor de acesso à unidade de cuidados intensivos pediátricos, posto de enfermagem, duas salas com três e cinco leitos, bem como nas unidades de isolamento. O equipamento utilizado foi calibrado para registrar a pressão do som em dBA, durante 24 horas, por 6 dias. Os dados foram analisados de acordo com as curvas gráficas registradas pelo equipamento. RESULTADOS: Foi identificado um nível basal de ruídos de 60 a 70 dBA, com pico de 120 dBA. Os níveis mais elevados foram identificados no período diurno, decorrentes da atividade e comunicação dos profissionais. CONCLUSÃO: Os níveis de ruídos identificados excederam as recomendações do International Noise Council, da Organização Mundial da Saúde. A educação sobre os efeitos prejudiciais de ruídos na audição humana e sua relação com o estresse constituem as bases para a implementação de programas de redução de ruídos.OBJECTIVE: The purpose of this study was to verify the noise level at a PICU. METHODS: This prospective observational study was performed in a 10 bed PICU at a teaching hospital located in a densely populated district within the city of São Paulo, Brazil. Sound pressure levels (dBA were measured 24 hours during a 6-day period. Noise recording equipment was placed in the PICU access corridor, nursing station, two open wards with three and five beds, and in isolation rooms. The resulting curves were analyzed. RESULTS: A basal noise level variation between 60 and 70 dBA was identified, with a maximum level of 120 dBA. The most significant noise levels were recorded during the day and were produced by the staff

  15. Hvilke emner mener du som praktiserende læge, at der skal forskes i?

    DEFF Research Database (Denmark)

    Ølgod, Jutta

    1997-01-01

    Knapt 100 alment praktiserende læger angav i en enquete, at man efterlyste forskning på en lang række felter. De tre hyppigst nævnte var "lægernes udbrændthed og manglende trivsel", "rygproblemer" og "psykosomatiske problemstillinger". Derudover udtryktes også stor interesse for "læge-patient for......Knapt 100 alment praktiserende læger angav i en enquete, at man efterlyste forskning på en lang række felter. De tre hyppigst nævnte var "lægernes udbrændthed og manglende trivsel", "rygproblemer" og "psykosomatiske problemstillinger". Derudover udtryktes også stor interesse for "læge......-patient forholdet", "definition af lægernes arbejdsområder", "rollen som forebygger og sundhedsfremmer" og "samarbejdsforhold". Resultaterne blev fremlagt på det 3. almenmedicinske forskningsseminar i Køge i 1996. Udgivelsesdato: 1997/7/15...

  16. Implementation of Self Organizing Map (SOM) as decision support: Indonesian telematics services MSMEs empowerment

    Science.gov (United States)

    Tosida, E. T.; Maryana, S.; Thaheer, H.; Hardiani

    2017-01-01

    Information technology and communication (telematics) is one of the most rapidly developing business sectors in Indonesia. It has strategic position in its contribution towards planning and implementation of developmental, economics, social, politics and defence strategies in business, communication and education. Aid absorption for the national telecommunication SMEs is relatively low; therefore, improvement is needed using analysis on business support cluster of which basis is types of business. In the study, the business support cluster analysis is specifically implemented for Indonesian telecommunication service. The data for the business are obtained from the National Census of Economic (Susenas 2006). The method used to develop cluster model is an Artificial Neural Network (ANN) system called Self-Organizing Maps (SOM) algorithm. Based on Index of Davies Bouldin (IDB), the accuracy level of the cluster model is 0.37 or can be categorized as good. The cluster model is developed to find out telecommunication business clusters that has influence towards the national economy so that it is easier for the government to supervise telecommunication business.

  17. Discrimination between Alzheimer's Disease and Mild Cognitive Impairment Using SOM and PSO-SVM

    Directory of Open Access Journals (Sweden)

    Shih-Ting Yang

    2013-01-01

    Full Text Available In this study, an MRI-based classification framework was proposed to distinguish the patients with AD and MCI from normal participants by using multiple features and different classifiers. First, we extracted features (volume and shape from MRI data by using a series of image processing steps. Subsequently, we applied principal component analysis (PCA to convert a set of features of possibly correlated variables into a smaller set of values of linearly uncorrelated variables, decreasing the dimensions of feature space. Finally, we developed a novel data mining framework in combination with support vector machine (SVM and particle swarm optimization (PSO for the AD/MCI classification. In order to compare the hybrid method with traditional classifier, two kinds of classifiers, that is, SVM and a self-organizing map (SOM, were trained for patient classification. With the proposed framework, the classification accuracy is improved up to 82.35% and 77.78% in patients with AD and MCI. The result achieved up to 94.12% and 88.89% in AD and MCI by combining the volumetric features and shape features and using PCA. The present results suggest that novel multivariate methods of pattern matching reach a clinically relevant accuracy for the a priori prediction of the progression from MCI to AD.

  18. Phase II trial of SOM230 (pasireotide LAR) in patients with unresectable hepatocellular carcinoma.

    Science.gov (United States)

    Feun, Lynn G; Wangpaichitr, Medhi; Li, Ying-Ying; Kwon, Deukwoo; Richman, Stephen P; Hosein, Peter J; Savaraj, Niramol

    2018-01-01

    A phase II trial of pasireotide was performed to assess its efficacy and safety in advanced or metastatic hepatocellular carcinoma (HCC). Patients with advanced HCC and Child-Pugh score ≤7 received pasireotide LAR 60 mg intramuscularly every 28 days. Primary endpoint was disease control rate. Secondary endpoints were time to tumor progression, response rate, treatment-related adverse events, and overall survival. Serum insulin growth factor-1 was measured before and after pasireotide. Twenty patients were treated and evaluable. Eighteen patients (90%) had prior therapy; 16 patients (80%) had multiple therapies. Median age was 65, 75% had Barcelona Clinic Liver Cancer stage C, and 55% had metastatic disease. The main toxicity was hyperglycemia. Rare adverse effects included reversible grade 4 elevation in alanina transaminase/aspartate transaminase in one patient. The best response was stable disease in 9 patients (45%). Median time to tumor progression for the 20 patients was 3 months, and median survival was 9 months. Pasireotide had limited clinical benefit as second-line or third-line treatment in patients with advanced or metastatic HCC. Low baseline insulin growth factor-1 level may be indicative when SOM230 treatment may be ineffective, and decreasing levels after treatment may be indicative of disease control.

  19. RICCI and matter collineations of som-roy chaudhary symmetric space time

    International Nuclear Information System (INIS)

    Ramzan, M.; Ahmed, Y.; Mufti, M.

    2018-01-01

    This paper is devoted to explore the RICCI and MCs (Matter Collineations of the Som-Ray Chaudhary spacetime. The spacetime under consideration is one of the spatially homogeneous and rotating spacetimes. Collineations are the some kinds of the Lie symmetries. To discuss the required collineations we have used the RICCI and energy momentum tensors. As the RICCI tensor is formulated from the metric tensor, it must possess its symmetries. RCs (RICCI Collineations) leads to conservation laws. On the other hand for the distribution of matter in the spacetimes, the symmetries of energy momentum tensor or MCs provides conservation laws on matter field. Throughout this paper, these collineations are discussed by vanishing Lie derivative of RICCI and energy momentum tensors respectively. Complete solution of the RCs and MCs equations, which are formed in the result of vanishing Lie derivative are explored. Studying all these collineations in the said spacetime, it has been shown that RCs of the spacetime form an infinite dimensional vector space where as MCs are Killing vector fields. (author)

  20. Memória de orientação espacial: avaliação em pacientes com doença de Alzheimer e com epilepsia mesial temporal refratária Spatial orientation memory: evaluation in patents with Alzheimer disease and temporal lobe epilepsy

    Directory of Open Access Journals (Sweden)

    Lisiane Tuon

    2006-06-01

    Full Text Available Estudos experimentais identificaram células piramidais no hipocampo de ratos com participação na memória de orientação espacial (MOE, denominadas células de localização. O objetivo deste estudo foi adaptar um teste baseado nesses experimentos para verificar o desempenho de MOE e a participação do hipocampo na MOE em pacientes com esclerose mesial temporal (EMT. Dividiu-se a pesquisa em dois estudos: no primeiro adaptou-se o teste e visando verificar sua capacidade de investigação de déficits de MOE aplicou-se em grupos de 10 indivíduos, um com doença de Alzheimer (DA e outro de idosos saudáveis (pExperimental studies have identified pyramidal cells in hippocampus in rats with participation in the spatial orientation memory (SOM, which are named location cells. This study had the purpose to adapt a test based in these experiments in order to check the performance of SOM and the participation of hippocampus into SOM in patients with mesial temporal sclerosis (MTS. The research was divided into two studies: the first one the test was adapted, and in order to check its capacity to investigate the deficits of SOM, it has applied in groups of 10 (ten subjects, one group with patients that have Alzheimer disease and the other one with healthy elderly (p<0.001. The second study has evaluated the participation of hippocampus into SOM in 43 patients (23 with mesial temporal sclerosis (MTS and 20 submitted to selective amygdala hippocampectomy (SAH and 23 healthy volunteers with p<0,05 between MTS and SAH and between controled and SAH. It was shown that the test of SOM is suitable to evaluate deficits, but it seems the SOM is not a specific function of human hippocampus.

  1. Bilderboken ur ett genusperspektiv : En bilderboksanalys av tre svenska böcker som utmanar stereotypa könsroller

    OpenAIRE

    Malmqvist, Hanna

    2015-01-01

    Syftet med denna studie är att se hur några bilderböcker utmanar de stereotypa könsrollerna. Jag kommer att granska hur pojkar och flickor framställs ur ett genusperspektiv och även titta på hur text och bild kompletterar varandra, med hjälp av Nikolajevas (2000) analysmodell för bilderböcker. Jag har valt att analysera tre stycken böcker och två av dessa har pojkar som huvudkaraktärer och en har en flicka som huvudkaraktär. Med den medvetenhet man har idag kring genus så kan dessa böcker var...

  2. Clustering self-organizing maps (SOM) method for human papillomavirus (HPV) DNA as the main cause of cervical cancer disease

    Science.gov (United States)

    Bustamam, A.; Aldila, D.; Fatimah, Arimbi, M. D.

    2017-07-01

    One of the most widely used clustering method, since it has advantage on its robustness, is Self-Organizing Maps (SOM) method. This paper discusses the application of SOM method on Human Papillomavirus (HPV) DNA which is the main cause of cervical cancer disease, the most dangerous cancer in developing countries. We use 18 types of HPV DNA-based on the newest complete genome. By using open-source-based program R, clustering process can separate 18 types of HPV into two different clusters. There are two types of HPV in the first cluster while 16 others in the second cluster. The analyzing result of 18 types HPV based on the malignancy of the virus (the difficultness to cure). Two of HPV types the first cluster can be classified as tame HPV, while 16 others in the second cluster are classified as vicious HPV.

  3. The biomonitoring and bioremediation of toxic water resulting from municipal waste storage of Somârd, Sibiu county

    OpenAIRE

    Ioan C. Oprea; Dana Malschi; Liviu O. Muntean

    2013-01-01

    This paper presents information from the specialty literature and laboratory experimental results on biomonitoring, phytoextraction, biodegradation, and biotransformation of toxic water pollutants at the biotechnology laboratory of the Faculty of Environmental Science and Engineering. The study was conducted in laboratory micro tanks with contaminated water from the municipal landfill water storage pit with toxic bund of Somârd/Medias, Sibiu County, in order to research and develo...

  4. Nitrogenfiksering som en episodisk proces i opstrømnings-området i det østlige tropiske Stillehav

    DEFF Research Database (Denmark)

    Christensen, Jens Tang

    organismer i en lang række områder, hvor man hidtil ikke troede nitrogenfiksering forekom, og det globale kvælstofregnskab er kommet i bedre balance. Næringsrige opstrømnings-områder, som Humboldt-strømmen langs Chile og Peru, har indtil for nylig ikke været steder, hvor man anså denne proces...

  5. [Exenteration of the Orbit for Basal Cell Carcinoma].

    Science.gov (United States)

    Furdová, A; Horkovičová, K; Krčová, I; Krásnik, V

    2015-08-01

    Primary treatment of basal cell carcinoma of the lower eyelid and the inner corner is essentially surgical, but advanced lesions require extensive surgical interventions. In some cases it is necessary to continue with the mutilating surgery--exenteration of the orbit. In this work we evaluate the indications of radical solutions in patients with basal cell carcinoma invading the orbit and the subsequent possibility for individually made prosthesis to cover the defect of the cavity. Indications to exenteration of the orbit in patients with basal cell carcinoma findings in 2008-2013. Case report of 2 patients. In period 2008-20013 at the Dept. of Ophthalmology, Comenius University in Bratislava totally 221 patients with histologically confirmed basal cell carcinoma of the eyelids and the inner corner were treated. In 5 cases (2.7 %) with infiltration of the orbit the radical surgical procedure, exenteration was necessary. In 3 patients exenteration was indicated as the first surgical procedure in the treatment of basal cell carcinoma, since they had never visited ophthalmologist before only at in the stage of infiltration of the orbit (stage T4). In one case was indicated exenteration after previous surgical interventions and relapses. After healing the cavity patients got individually prepared epithesis. Surgical treatment of basal cell carcinoma involves the radical removal of the neoplasm entire eyelid and stage T1 or T2 can effectively cure virtually all tumors with satisfactory cosmetic and functional results. In advanced stages (T4 stage) by infiltrating the orbit by basal cell carcinoma exenteration of the orbit is necessary. This surgery is a serious situation for the patient and also for his relatives. Individually made prosthesis helps the patient to be enrolled to the social environment.

  6. Vismodegib (ERIVEDGE°) In basal cell carcinoma: too many unknowns.

    Science.gov (United States)

    2015-01-01

    Basal cell carcinomas are the most common skin cancers. They are usually localised and carry a good prognosis. There is no standard treatment for the rare patients with metastatic basal cell carcinoma or very extensive basal cell carcinoma for whom surgery or radiotherapy is inappropriate. Vismodegib, a cytotoxic drug, is claimed to prevent tumour growth by inhibiting a pathway involved in tissue repair and embryogenesis. It has been authorised in the European Union for patients with metastatic or locally advanced and extensive basal cell carcinoma. Clinical evaluation of vismodegib is based on a non-comparative clinical trial involving 104 patients, providing only weak evidence. Twenty-one months after the start of the trial, 7 patients with metastases (21%) and 6 patients with advanced basal cell carcinoma (10%) had died. Given the lack of a placebo group, there is no way of knowing whether vismodegib had any effect, positive or negative, on survival. There were no complete responses among patients with metastases, but about one-third of them had partial responses. Among the 63 patients with locally advanced basal cell carcinoma, there were 14 complete responses and 16 partial responses. The recurrence rate in patients with complete responses was not reported. Similar results were reported in two other uncontrolled trials available in mid-2014. Vismodegib has frequent and sometimes serious adverse effects, including muscle spasms, fatigue and severe hyponatraemia. Cases of severe weight loss, alopecia, ocular disorders, other cancers (including squamous cell carcinoma) and anaemia have also been reported. More data are needed on possible hepatic and cardiovascular adverse effects. A potent teratogenic effect was seen in experimental animals. As vismodegib enters semen, contraception is mandatory for both men (condoms) and women. In practice, vismodegib has frequent and varied adverse effects, some of which are serious, while its benefits are poorly documented

  7. Historien om <em>Judasevangeliet>

    DEFF Research Database (Denmark)

    Pedersen, Nils Arne

    2008-01-01

    Gennem en detaljeret historisk-filologisk argumentation viser artiklen dels, at det nyligt publicerede koptiske Judasevangelium næppe kan være en oversættelse af det Judasevangelium, som Irenæus nævner, dels at det forudsætter kendskab til en ældre, skriftlig evangelielitteratur. På denne baggrun...

  8. Sinéreses cromossômicas: projeto de complementaridade semiósica entre som e cor

    Directory of Open Access Journals (Sweden)

    Eufrásio Prates

    2008-11-01

    Full Text Available O trabalho de Basbaum transita, transdisciplinarmente, pelos campos da neurologia cognitiva, arte, fí­sica, matemática, tecnologia, misticismo e teosofia, trazidos à baila para compor a teia da sinestesia ontológica do cromo-som, complexo indissociável e simultâneo de som e cor, como busca de interconexões originárias entre som e cor a partir da esfera da primeiridade peirciana, da constituição mesma do fenômeno sinestésico. Palavras-chave Sinestesia, primeiridade. Abstract The work of Basbaum as a research on the originary interconnections between sound and color based upon the Peircian firstness sphere concern, the constitution of the synesthesic phenomenon itself , goes transdisciplinarly through the fields of cognitive neurology, arts, physics, mathematics, technology, mysticism and theosophy, all of them with regard to the weaving of the ontological; synesthesia of the chromosound, an indissociable and simultaneous complex ofsound and color. Keywords Synesthesic phenomenon, Peircian firstness.

  9. Pædagogiske læreplaner som redskab til evaluering, læring og kvalitetsudvikling?

    Directory of Open Access Journals (Sweden)

    Poul Skov Dahl

    2016-02-01

    Full Text Available Den nyligt afsluttede, landsdækkende evaluering af loven om pædagogiske læreplaner har vist, at pædagogiske læreplaner indtil nu har været en faglig succes i dagtilbuddene. Men den viser også, at evalueringsarbejdet endnu spiller en begrænset rolle i arbejdet. Hvis de pædagogiske læreplaner fremadrettet skal forblive en succes og medvirke til at udvikle den pædagogiske praksis, er evalueringskapacitet et vigtigt omdrejningspunkt. Med systematisk evaluering som en integreret del af arbejdet med de pædagogiske læreplaner har de - som en form for ”systemtænknings-redskab -” potentiale til at være løftestang for organisatorisk læring i dagtilbuddet - den læring, som er en forudsætning for kvalitetsudviklingen af den pædagogiske praksis. Vi sætter i denne artikel fokus på sammenhængen mellem pædagogiske læreplaner, evaluering og organisatorisk læring i dagtilbuddene.

  10. Yrkesforberedelse eller fagopplæring med fagbrev? Med design og håndverk som kontekst

    Directory of Open Access Journals (Sweden)

    Bjørn Magne Aakre

    2013-09-01

    Full Text Available Artikkelen drøfter forholdet mellom yrkesforberedelse og fagopplæring med utgangspunkt i den kombinerte studieretningen formgivingsfag som ble innført i Norge i 1994. I 2006 ble den delt i et programfag under studiespesialiserende fag, og et nytt yrkesfaglig program med betegnelse design og håndverk. Hvilke interesser lå til grunn for endringene, hvor dyptgripende ble de og hvilke overveieleser kan en gjøre i ettertid om forholdet mellom yrkesforberedelse og fagopplæring? Artikkelen søker å svare på spørsmålene ut fra relevante dokumenter og to kvantitative undersøkelser med elever og lærere som informanter. Artikkelen konkluderer med at innholdet forble nokså likt, antall elever ble halvert og at frafallet økte. Det konkluderes videre med at mange forhold bidrar til å legitimere et fag og dets innhold som henholdsvis skolefag, vitenskapsfag eller yrkesfag. Legitimeringen preges ofte av motstridende motiver og interesser, og sjelden bare faglige begrunnelser.

  11. Innovativ formidling af førsteårsstuderende som et design-based research-forløb

    Directory of Open Access Journals (Sweden)

    Ole Eggers Bjælde

    2016-11-01

    Full Text Available 14 videoproduktioner, 4 tegneserier, 3 filmfortællinger, 2 sange, 2 nyhedsindslag, 2 børnebøger, 2 facebook-sider, 1 novelle og 1 toiletrulle var blandt resultaterne, da 112 førsteårsstuderende i det obligatoriske kursus Astrofysik på fysikuddannelsen på Aarhus Universitet blev deltagere i et learning design-forløb, som en del af deres eksamen i kurset. Målet med forløbet var dels at sætte fokus på faglig formidling som en væsentlig kompetence blandt universitetsstuderende, men samtidig også at bringe værdier som kreativitet og innovation i spil. Forløbet var tilrettelagt efter principperne for design-based research, og publikationen her sætter fokus på intention, implementering, realisering og perspektivering af det underliggende design med henblik på forbedring af designet til fremtidig brug samt på en vurdering af forløbets samlede impact.

  12. Estimativa da erodibilidade pela desagregação por ultra-som e atributos de solos com horizonte B textural Estimating soil erodibility from sonication indexes and other attributes of textural B horizon soils

    Directory of Open Access Journals (Sweden)

    Marcos Aurélio Carolino de Sá

    2004-07-01

    Full Text Available A erodibilidade de solos é um fator importante na estimativa das perdas por erosão. Este fator é uma expressão da combinação de atributos do solo, os quais possibilitam sua estimativa por meio de equações. O objetivo deste trabalho foi medir atributos químicos e mineralógicos que, combinados com índices de estabilidade de agregados determinados por ultra-som, pudessem ser utilizados como variáveis em modelos na estimativa da erodibilidade de solos com horizonte B textural do Brasil. Estes atributos foram determinados em 22 solos de erodibilidade conhecida, medida diretamente em parcelas no campo. Atributos de 21 dos solos foram utilizados no ajuste dos modelos. Um dos solos (Argissolo Vermelho-Amarelo foi escolhido ao acaso para teste. De 96 variáveis, 15 foram incluídas nos modelos de estimativa da erodibilidade. A maioria delas é representada por índices de desagregação por sonificação de amostras do horizonte A. Foram obtidos quatro modelos para estimar a erodibilidade, com R² variando entre 0,83** e 0,91**. A erodibilidade pode ser estimada com base na estabilidade de agregados por ultra-som.Soil erodibility is an important factor for estimating soil erosion losses. This factor is an expression of combined soil attributes, which make possible its estimation by equations. The objective of this study was to measure some chemical and mineralogical attributes, and to combine them with aggregate stability indexes from sonication analysis, in equations in order to estimate soil erodibility of textural B horizon soils from Brazil. These attributes were measured for 22 soils that had their erodibility measured from field plots. Attributes of 21 soils were used to adjust the equations. One of the soils (Red-Yellow Argisol was used to test the equations. From 96 variables, 15 were significantly correlated to soil erodibility. Most of them are represented by the disruption indexes from sonication analysis of A horizon samples. This

  13. Synthesis, Crystal Structure and Luminescent Property of Cd (II Complex with <em>N-Benzenesulphonyl-L>-leucine

    Directory of Open Access Journals (Sweden)

    Xishi Tai

    2012-09-01

    Full Text Available A new trinuclear Cd (II complex [Cd3(L6(2,2-bipyridine3] [L =<em> Nem>-phenylsulfonyl-L>-leucinato] has been synthesized and characterized by elemental analysis, IR and X-ray single crystal diffraction analysis. The results show that the complex belongs to the orthorhombic, space group<em> Pem>212121 with<em> aem> = 16.877(3 Å, <em>b> em>= 22.875(5 Å, <em>c em>= 29.495(6 Å, <em>α> em>= <emem>= <emem>= 90°, <em>V> em>= 11387(4 Å3, <em>Z> em>= 4, <em>Dc>= 1.416 μg·m−3, <emem>= 0.737 mm−1, <em>F> em>(000 = 4992, and final <em>R>1 = 0.0390, <em>ωR>2 = 0.0989. The complex comprises two seven-coordinated Cd (II atoms, with a N2O5 distorted pengonal bipyramidal coordination environment and a six-coordinated Cd (II atom, with a N2O4 distorted octahedral coordination environment. The molecules form one dimensional chain structure by the interaction of bridged carboxylato groups, hydrogen bonds and p-p interaction of 2,2-bipyridine. The luminescent properties of the Cd (II complex and <em>N-Benzenesulphonyl-L>-leucine in solid and in CH3OH solution also have been investigated.

  14. Basal hypercortisolism and trauma in patients with psychogenic nonepileptic seizures.

    Science.gov (United States)

    Bakvis, Patricia; Spinhoven, Philip; Giltay, Erik J; Kuyk, Jarl; Edelbroek, Peter M; Zitman, Frans G; Roelofs, Karin

    2010-05-01

    Several studies have indicated that psychogenic nonepileptic seizures (PNES) are associated with psychological trauma, but only a few studies have examined the associations with neurobiologic stress systems, such as the hypothalamus-pituitary-adrenal (HPA) axis and its end-product cortisol. We tested several relevant HPA-axis functions in patients with PNES and related them to trauma history. Cortisol awakening curve, basal diurnal cortisol, and negative cortisol feedback (using a 1 mg dexamethasone suppression test) were examined in 18 patients with PNES and 19 matched healthy controls (HCs) using saliva cortisol sampling on two consecutive days at 19 time points. Concomitant sympathetic nervous system (SNS) activity was assessed by analyzing saliva alpha-amylase (sAA). Patients with PNES showed significantly increased basal diurnal cortisol levels compared to HCs. This effect was driven mainly by patients reporting sexual trauma who showed a trend toward higher cortisol levels as compared to patients without a sexual trauma report. Importantly, the increased basal diurnal cortisol levels in patients were not explained by depression, medication, or smoking, or by current seizures or group differences in SNS activity. This is the first study showing that basal hypercortisolism in patients with PNES is independent of the acute occurrence of seizures. In addition, basal hypercortisolism was more pronounced in traumatized patients with PNES as compared to nontraumatized patients with PNES. These findings suggest that HPA-axis activity provides a significant neurobiologic marker for PNES.

  15. Clinicopathological evaluation of radiation induced basal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Meibodi Naser

    2008-01-01

    Full Text Available Background: Development of skin neoplasms is one of the most important chronic complications of radiation therapy. Basal cell carcinoma (BCC is the most frequent carcinoma occurring at the region of the body to which radiotherapy was delivered. Aim: The aim of this study was to evaluate clinical and histological aspects of basal cell carcinoma in patients with a history of radiotherapy. Materials and Methods: Medical records and microscopic slides of 80 patients with basal cell carcinoma who had received radiotherapy (1996-2006 were reviewed in pathology department of Imam Reza hospital of Mashhad, Iran. Collected data were analyzed statistically using descriptive test. Results: 60 men and 20 women were included, majority of them in their sixties. Plaque was the most common clinical pattern of basal cell carcinoma. Fifty one percent of the patients had pigmented and 42.5% had multiple lesions. Scalp was the most common site of involvement. Histologically, macronodular and pigmented carcinoma were the most predominant forms of basal cell carcinoma. Discussion: Majority of patients had scalp involvement and multiple lesions. Nodular and pigmented forms were the most common histological findings. We suggest the need for close supervision in patients with a history of radio therapy in the past.

  16. Basal ganglia circuits changes in Parkinson's disease patients.

    Science.gov (United States)

    Wu, Tao; Wang, Jue; Wang, Chaodong; Hallett, Mark; Zang, Yufeng; Wu, Xiaoli; Chan, Piu

    2012-08-22

    Functional changes in basal ganglia circuitry are responsible for the major clinical features of Parkinson's disease (PD). Current models of basal ganglia circuitry can only partially explain the cardinal symptoms in PD. We used functional MRI to investigate the causal connectivity of basal ganglia networks from the substantia nigra pars compacta (SNc) in PD in the movement and resting state. In controls, SNc activity predicted increased activity in the supplementary motor area, the default mode network, and dorsolateral prefrontal cortex, but, in patients, activity predicted decreases in the same structures. The SNc had decreased connectivity with the striatum, globus pallidus, subthalamic nucleus, thalamus, supplementary motor area, dorsolateral prefrontal cortex, insula, default mode network, temporal lobe, cerebellum, and pons in patients compared to controls. Levodopa administration partially normalized the pattern of connectivity. Our findings show how the dopaminergic system exerts influences on widespread brain networks, including motor and cognitive networks. The pattern of basal ganglia network connectivity is abnormal in PD secondary to dopamine depletion, and is more deviant in more severe disease. Use of functional MRI with network analysis appears to be a useful method to demonstrate basal ganglia pathways in vivo in human subjects. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  17. Toward sophisiticated basal ganglia neuromodulation: review on basal gaglia deep brain stimulation

    Science.gov (United States)

    Da Cunha, Claudio; Boschen, Suelen L.; Gómez-A, Alexander; Ross, Erika K.; Gibson, William S. J.; Min, Hoon-Ki; Lee, Kendall H.; Blaha, Charles D.

    2015-01-01

    This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in action-selection, cognition, and motivation, and how this knowledge has been used to improve deep brain stimulation (DBS) treatment of neurological and psychiatric disorders. Such pathological conditions include Parkinson’s disease, Huntington’s disease, Tourette syndrome, depression, and obsessive-compulsive disorder. The first section presents evidence supporting current hypotheses of how the cortico-BG circuitry works to select motor and emotional actions, and how defects in this circuitry can cause symptoms of the BG diseases. Emphasis is given to the role of striatal dopamine on motor performance, motivated behaviors and learning of procedural memories. Next, the use of cutting-edge electrochemical techniques in animal and human studies of BG functioning under normal and disease conditions is discussed. Finally, functional neuroimaging studies are reviewed; these works have shown the relationship between cortico-BG structures activated during DBS and improvement of disease symptoms. PMID:25684727

  18. Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation.

    Science.gov (United States)

    Da Cunha, Claudio; Boschen, Suelen L; Gómez-A, Alexander; Ross, Erika K; Gibson, William S J; Min, Hoon-Ki; Lee, Kendall H; Blaha, Charles D

    2015-11-01

    This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in action-selection, cognition, and motivation, and how this knowledge has been used to improve deep brain stimulation (DBS) treatment of neurological and psychiatric disorders. Such pathological conditions include Parkinson's disease, Huntington's disease, Tourette syndrome, depression, and obsessive-compulsive disorder. The first section presents evidence supporting current hypotheses of how the cortico-BG circuitry works to select motor and emotional actions, and how defects in this circuitry can cause symptoms of the BG diseases. Emphasis is given to the role of striatal dopamine on motor performance, motivated behaviors and learning of procedural memories. Next, the use of cutting-edge electrochemical techniques in animal and human studies of BG functioning under normal and disease conditions is discussed. Finally, functional neuroimaging studies are reviewed; these works have shown the relationship between cortico-BG structures activated during DBS and improvement of disease symptoms. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. The genera <em>Conocybe> and <em>Pholiotina> (Agaricomycotina, Bolbitiaceae) in temperate Asia

    DEFF Research Database (Denmark)

    Hausknecht, Anton; Kalamees, Kuulo; Knudsen, Henning Jørgen

    2009-01-01

    . En række arter repræsenterer nye fund for Asien, for Sibirien eller for Georgien, Tadjikistan, Turkmenistan eller Kazakstan. Et mycogeografisk element repræsenteres af C. enderlei, C. herbarum, C. graminis, C. leporina og C. subxerophytica, som er knyttet til tørre, steppeagtige områder med høj pH...

  20. Phase II trial of SOM230 (pasireotide LAR in patients with unresectable hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    Feun LG

    2018-01-01

    Full Text Available Lynn G Feun,¹ Medhi Wangpaichitr,² Ying-Ying Li,¹ Deukwoo Kwon,³ Stephen P Richman,¹ Peter J Hosein,¹ Niramol Savaraj¹,² ¹Department of Medicine, Medical Oncology, Sylvester Comprehensive Cancer Center, University of Miami, ²Department of Surgery, Miami VA Healthcare System, Research Service, ³Biostatistics and Bioinformatics Core, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA Background: A phase II trial of pasireotide was performed to assess its efficacy and safety in advanced or metastatic hepatocellular carcinoma (HCC.Patients and methods: Patients with advanced HCC and Child–Pugh score ≤7 received pasireotide LAR 60 mg intramuscularly every 28 days. Primary endpoint was disease control rate. Secondary endpoints were time to tumor progression, response rate, treatment-related adverse events, and overall survival. Serum insulin growth factor-1 was measured before and after pasireotide.Results: Twenty patients were treated and evaluable. Eighteen patients (90% had prior therapy; 16 patients (80% had multiple therapies. Median age was 65, 75% had Barcelona Clinic Liver Cancer stage C, and 55% had metastatic disease. The main toxicity was hyperglycemia. Rare adverse effects included reversible grade 4 elevation in alanina transaminase/aspartate transaminase in one patient. The best response was stable disease in 9 patients (45%. Median time to tumor progression for the 20 patients was 3 months, and median survival was 9 months.Conclusion: Pasireotide had limited clinical benefit as second-line or third-line treatment in patients with advanced or metastatic HCC. Low baseline insulin growth factor-1 level may be indicative when SOM230 treatment may be ineffective, and decreasing levels after treatment may be indicative of disease control. Keywords: pasireotide, hepatocellular carcinoma, insulin growth factor-1