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Sample records for solvable potentials ii

  1. Exactly solvable energy-dependent potentials

    International Nuclear Information System (INIS)

    Garcia-Martinez, J.; Garcia-Ravelo, J.; Pena, J.J.; Schulze-Halberg, A.

    2009-01-01

    We introduce a method for constructing exactly-solvable Schroedinger equations with energy-dependent potentials. Our method is based on converting a general linear differential equation of second order into a Schroedinger equation with energy-dependent potential. Particular examples presented here include harmonic oscillator, Coulomb and Morse potentials with various types of energy dependence.

  2. Solvable potentials derived from supersymmetric quantum mechanics

    International Nuclear Information System (INIS)

    Levai, G.

    1994-01-01

    The introduction of supersymmetric quantum mechanics has generated renewed interest in solvable problems of non-relativistic quantum mechanics. This approach offers an elegant way to describe different, but isospectral potentials by interpreting the degeneracy of their energy levels in terms of supersymmetry. The original ideas of supersymmetric quantum mechanics have been developed further in many respects in the past ten years, and have been applied to a large variety of physical problems. The purpose of this contribution is to give a survey of supersymmetric quantum mechanics and its applications to solvable quantum mechanical potentials. Its relation to other models describing isospectral potentials is also discussed here briefly, as well as some of its practical applications in various branches of physics. (orig.)

  3. A simple method for generating exactly solvable quantum mechanical potentials

    CERN Document Server

    Williams, B W

    1993-01-01

    A simple transformation method permitting the generation of exactly solvable quantum mechanical potentials from special functions solving second-order differential equations is reviewed. This method is applied to Gegenbauer polynomials to generate an attractive radial potential. The relationship of this method to the determination of supersymmetric quantum mechanical superpotentials is discussed, and the superpotential for the radial potential is also derived. (author)

  4. Exactly Solvable Quantum Mechanical Potentials: An Alternative Approach.

    Science.gov (United States)

    Pronchik, Jeremy N.; Williams, Brian W.

    2003-01-01

    Describes an alternative approach to finding exactly solvable, one-dimensional quantum mechanical potentials. Differs from the usual approach in that instead of starting with a particular potential and seeking solutions to the related Schrodinger equations, it begins with known solutions to second-order ordinary differential equations and seeks to…

  5. Supersymmetric construction of exactly solvable potentials and nonlinear algebras

    International Nuclear Information System (INIS)

    Junker, G.; Roy, P.

    1998-01-01

    Using algebraic tools of supersymmetric quantum mechanics we construct classes of conditionally exactly solvable potentials being the supersymmetric partners of the linear or radial harmonic oscillator. With the help of the raising and lowering operators of these harmonic oscillators and the SUSY operators we construct ladder operators for these new conditionally solvable systems. It is found that these ladder operators together with the Hamilton operator form a nonlinear algebra which is of quadratic and cubic type for the SUSY partners of the linear and radial harmonic oscillator

  6. Eight exactly solvable comples potentials in Bender - Boettcher quantum mechanics

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2001-01-01

    Roč. 2, č. 66 (2001), s. 213-218 ISSN 0009-725X. [The 20th Winter Schooll "Geometry and Physics". Srní, 15.01.2000-22.01.2000] R&D Projects: GA AV ČR IAA1048004 Keywords : solvable * potentials * bound-state Subject RIV: BE - Theoretical Physics

  7. Solvable linear potentials in the Dirac equation

    International Nuclear Information System (INIS)

    Dominguez-Adame, F.; Gonzalez, M.A.

    1990-01-01

    The Dirac equation for some linear potentials leading to Schroedinger-like oscillator equations for the upper and lower components of the Dirac spinor have been solved. Energy levels for the bound states appear in pairs, so that both particles and antiparticles may be bound with the same energy. For weak coupling, the spacing between levels is proportional to the coupling constant while in the strong limit those levels are depressed compared to the nonrelativistic ones

  8. Asymptotic properties of solvable PT-symmetric potentials

    International Nuclear Information System (INIS)

    Levai, G.

    2010-01-01

    Compete text of publication follows. The introduction of PT-symmetric quantum mechanics generated renewed interest in non-hermitian quantum mechanical systems in the past decade. PT symmetry means the invariance of a Hamiltonian under the simultaneous P space and T time reflection, the latter understood as complex conjugation. Considering the Schroedinger equation in one dimension, this corresponds to a potential with even real and odd imaginary components. This implies a delicate balance of emissive and absorptive regions that eventually manifests itself in properties that typically characterize real potentials, i.e. hermitian systems. These include partly or fully real energy spectrum and conserved (pseudo-)norm. A particularly notable feature of these systems is the spontaneous breakdown of PT symmetry, which typically occurs when the magnitude of the imaginary potential component exceeds a certain limit. At this point the real energy eigenvalues begin to merge pairwise and re-emerge as complex conjugate pairs. Another unusual property of PT-symmetric potentials is that they can, or sometimes have to be defined off the real x axis on trajectories that are symmetric with respect to the imaginary x axis. After more than a decade of theoretical investigations a remarkable recent development was the experimental verification of the existence of PT-symmetric systems in nature and the occurrence of spontaneous PT symmetry breaking in them. The experimental setup was a waveguide containing regions where loss and gain of flux occurred in a set out prescribed by PT symmetry. These experimental developments require the study of PT -symmetric potentials with various asymptotics, in which, furthermore, the complex potential component is finite in its range and/or its magnitude. Having in mind that PT symmetry allows for a wider variety of asymptotic properties than hermeticity, we studied three exactly solvable PT-symmetric potentials and compared their scattering and bound

  9. Application of quasiexactly solvable potential method to the N-body ...

    Indian Academy of Sciences (India)

    The quasiexactly solvable potential method is used to determine the energies and the corresponding exact eigenfunctions for a system of N particles with equal mass interacting via an anharmonic potential. For systems with five and seven particles, we compute the ground state and the first excited state only, and compare ...

  10. Application of quasiexactly solvable potential method to the N-body ...

    Indian Academy of Sciences (India)

    physics pp. 985–996. Application of quasiexactly solvable potential method to the N-body ... Application of QES method to N-particle quantum model interacting via an ... Now, if we choose the centre of mass R as the origin of the coordinates,.

  11. The Lambert-W step-potential – an exactly solvable confluent hypergeometric potential

    Energy Technology Data Exchange (ETDEWEB)

    Ishkhanyan, A.M., E-mail: aishkhanyan@gmail.com [Institute for Physical Research, NAS of Armenia, 0203 Ashtarak (Armenia); Armenian State Pedagogical University, 0010 Yerevan (Armenia); Institute of Physics and Technology, National Research Tomsk Polytechnic University, Tomsk 634050 (Russian Federation)

    2016-02-15

    We present an asymmetric step–barrier potential for which the one-dimensional stationary Schrödinger equation is exactly solved in terms of the confluent hypergeometric functions. The potential is given in terms of the Lambert W-function, which is an implicitly elementary function also known as the product logarithm. We present the general solution of the problem and consider the quantum reflection at transmission of a particle above this potential barrier. Compared with the abrupt-step and hyperbolic tangent potentials, which are reproduced by the Lambert potential in certain parameter and/or variable variation regions, the reflection coefficient is smaller because of the lesser steepness of the potential on the particle incidence side. Presenting the derivation of the Lambert potential we show that this is a four-parametric sub-potential of a more general five-parametric one also solvable in terms of the confluent hypergeometric functions. The latter potential, however, is a conditionally integrable one. Finally, we show that there exists one more potential the solution for which is written in terms of the derivative of a bi-confluent Heun function. - Highlights: • We introduce an asymmetric step-barrier potential for which the 1D Schrödinger equation is exactly solved in terms of confluent hypergeometric functions. • The potential is given in terms of the Lambert-function, which is an implicitly elementary function also known as the product logarithm. • This is a four-parametric specification of a more general five-parametric potential also solvable in terms of the confluent hypergeometric functions. • There exists one more potential the solution for which is written in terms of the derivative of a bi-confluent Heun function.

  12. Semiclassical analysis of quasiexact solvability

    International Nuclear Information System (INIS)

    Bender, C.M.; Dunne, G.V.; Moshe, M.

    1997-01-01

    Higher-order WKB methods are used to investigate the border between the solvable and insolvable portions of the spectrum of quasiexactly solvable quantum-mechanical potentials. The analysis reveals scaling and factorization properties that are central to quasiexact solvability. These two properties define a new class of semiclassically quasiexactly solvable potentials. copyright 1997 The American Physical Society

  13. New rational extensions of solvable potentials with finite bound state spectrum

    International Nuclear Information System (INIS)

    Grandati, Yves

    2012-01-01

    Using the disconjugacy properties of the Schrödinger equation, we develop a new type of generalized SUSY QM partnership which allows generating new solvable rational extensions for translationally shape invariant potentials having a finite bound state spectrum. For this we prolong the dispersion relation relating the energy to the quantum number out of the physical domain until a disconjugacy sector. By Darboux–Bäcklund Transformations built on these prolonged states we obtain new regular isospectral extensions of the initial potential. We give the spectra of these extensions in terms of new orthogonal polynomials and study their shape invariance properties. -- Highlights: ► New solvable quantum potentials. ► SUSY quantum partnership generalized to excited states. ► Based on disconjugacy theorems and asymptotic behaviour. ► Exact spectrum in terms of new orthogonal polynomials. ► Enlarged shape invariance property.

  14. A conditionally exactly solvable generalization of the inverse square root potential

    Energy Technology Data Exchange (ETDEWEB)

    Ishkhanyan, A.M., E-mail: aishkhanyan@gmail.com [Institute for Physical Research, NAS of Armenia, Ashtarak 0203 (Armenia); Armenian State Pedagogical University, Yerevan 0010 (Armenia); Institute of Physics and Technology, National Research Tomsk Polytechnic University, Tomsk 634050 (Russian Federation)

    2016-11-25

    We present a conditionally exactly solvable singular potential for the one-dimensional Schrödinger equation which involves the exactly solvable inverse square root potential. Each of the two fundamental solutions that compose the general solution of the problem is given by a linear combination with non-constant coefficients of two confluent hypergeometric functions. Discussing the bound-state wave functions vanishing both at infinity and in the origin, we derive the exact equation for the energy spectrum which is written using two Hermite functions of non-integer order. In specific auxiliary variables this equation becomes a mathematical equation that does not refer to a specific physical context discussed. In the two-dimensional space of these auxiliary variables the roots of this equation draw a countable infinite set of open curves with hyperbolic asymptotes. We present an analytic description of these curves by a transcendental algebraic equation for the involved variables. The intersections of the curves thus constructed with a certain cubic curve provide a highly accurate description of the energy spectrum. - Highlights: • We present a conditionally exactly solvable singular potential for 1D Schrödinger equation. • Each of the two fundamental solutions is given by a linear combination with non-constant coefficients of two confluent hypergeometric functions. • The exact equation for the energy spectrum is written using two Hermite functions that do not reduce to polynomials.

  15. Duality and self-duality (energy reflection symmetry) of quasi-exactly solvable periodic potentials

    International Nuclear Information System (INIS)

    Dunne, Gerald V.; Shifman, M.

    2002-01-01

    A class of spectral problems with a hidden Lie-algebraic structure is considered. We define a duality transformation which maps the spectrum of one quasi-exactly solvable (QES) periodic potential to that of another QES periodic potential. The self-dual point of this transformation corresponds to the energy-reflection symmetry found previously for certain QES systems. The duality transformation interchanges bands at the bottom (top) of the spectrum of one potential with gaps at the top (bottom) of the spectrum of the other, dual, potential. Thus, the duality transformation provides an exact mapping between the weak coupling (perturbative) and semiclassical (nonperturbative) sectors

  16. One-dimensional Schrodinger equation with non-analytic potential V(x) = -g(2) exp (- vertical bar x vertical bar) and its exact Bessel-function solvability

    Czech Academy of Sciences Publication Activity Database

    Sasaki, R.; Znojil, Miloslav

    2016-01-01

    Roč. 49, č. 44 (2016), č. článku 445303. ISSN 1751-8113 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : non-analytic potentials * bound states * reflection and transmission * exactly solvable * orthogonality theorems * associated Hamiltonians * supersymmetry Subject RIV: BE - Theoretical Physics Impact factor: 1.857, year: 2016

  17. A position-dependent mass model for the Thomas–Fermi potential: Exact solvability and relation to δ-doped semiconductors

    Energy Technology Data Exchange (ETDEWEB)

    Schulze-Halberg, Axel, E-mail: xbataxel@gmail.com [Department of Mathematics and Actuarial Science, Indiana University Northwest, 3400 Broadway, Gary IN 46408 (United States); García-Ravelo, Jesús; Pacheco-García, Christian [Escuela Superior de Física y Matemáticas, Instituto Politécnico Nacional, Unidad Profesional Adolfo López Mateos, Zacatenco, 07738 México D.F. (Mexico); Juan Peña Gil, José [Universidad Autónoma Metropolitana - Azcapotzalco, CBI - Area de Física Atómica Molecular Aplicada, Av. San Pablo 180, Reynosa Azcapotzalco, 02200 México D.F. (Mexico)

    2013-06-15

    We consider the Schrödinger equation in the Thomas–Fermi field, a model that has been used for describing electron systems in δ-doped semiconductors. It is shown that the problem becomes exactly-solvable if a particular effective (position-dependent) mass distribution is incorporated. Orthogonal sets of normalizable bound state solutions are constructed in explicit form, and the associated energies are determined. We compare our results with the corresponding findings on the constant-mass problem discussed by Ioriatti (1990) [13]. -- Highlights: ► We introduce an exactly solvable, position-dependent mass model for the Thomas–Fermi potential. ► Orthogonal sets of solutions to our model are constructed in closed form. ► Relation to delta-doped semiconductors is discussed. ► Explicit subband bottom energies are calculated and compared to results obtained in a previous study.

  18. A position-dependent mass model for the Thomas–Fermi potential: Exact solvability and relation to δ-doped semiconductors

    International Nuclear Information System (INIS)

    Schulze-Halberg, Axel; García-Ravelo, Jesús; Pacheco-García, Christian; Juan Peña Gil, José

    2013-01-01

    We consider the Schrödinger equation in the Thomas–Fermi field, a model that has been used for describing electron systems in δ-doped semiconductors. It is shown that the problem becomes exactly-solvable if a particular effective (position-dependent) mass distribution is incorporated. Orthogonal sets of normalizable bound state solutions are constructed in explicit form, and the associated energies are determined. We compare our results with the corresponding findings on the constant-mass problem discussed by Ioriatti (1990) [13]. -- Highlights: ► We introduce an exactly solvable, position-dependent mass model for the Thomas–Fermi potential. ► Orthogonal sets of solutions to our model are constructed in closed form. ► Relation to delta-doped semiconductors is discussed. ► Explicit subband bottom energies are calculated and compared to results obtained in a previous study

  19. Quantum models with energy-dependent potentials solvable in terms of exceptional orthogonal polynomials

    International Nuclear Information System (INIS)

    Schulze-Halberg, Axel; Roy, Pinaki

    2017-01-01

    We construct energy-dependent potentials for which the Schrödinger equations admit solutions in terms of exceptional orthogonal polynomials. Our method of construction is based on certain point transformations, applied to the equations of exceptional Hermite, Jacobi and Laguerre polynomials. We present several examples of boundary-value problems with energy-dependent potentials that admit a discrete spectrum and the corresponding normalizable solutions in closed form.

  20. Quantum models with energy-dependent potentials solvable in terms of exceptional orthogonal polynomials

    Energy Technology Data Exchange (ETDEWEB)

    Schulze-Halberg, Axel, E-mail: axgeschu@iun.edu [Department of Mathematics and Actuarial Science, Indiana University Northwest, 3400 Broadway, Gary IN 46408 (United States); Department of Physics, Indiana University Northwest, 3400 Broadway, Gary IN 46408 (United States); Roy, Pinaki, E-mail: pinaki@isical.ac.in [Physics and Applied Mathematics Unit, Indian Statistical Institute, Kolkata 700108 (India)

    2017-03-15

    We construct energy-dependent potentials for which the Schrödinger equations admit solutions in terms of exceptional orthogonal polynomials. Our method of construction is based on certain point transformations, applied to the equations of exceptional Hermite, Jacobi and Laguerre polynomials. We present several examples of boundary-value problems with energy-dependent potentials that admit a discrete spectrum and the corresponding normalizable solutions in closed form.

  1. Conditionally solvable path integral problems

    International Nuclear Information System (INIS)

    Grosche, C.

    1995-05-01

    Some specific conditionally exactly solvable potentials are discussed within the path integral formalism. They generalize the usually known potentials by the incorporation of a fractional power behaviour and strongly anharmonic terms. We find four different kinds of such potentials, the first is related to the Coulomb potential, the second is an anharmonic confinement potential, and the third and the fourth are related to the Manning-Rosen potential. (orig.)

  2. Quasi-exact solvability

    International Nuclear Information System (INIS)

    Ushveridze, A.G.

    1992-01-01

    This paper reports that quasi-exactly solvable (QES) models realize principally new type of exact solvability in quantum physics. These models are distinguished by the fact that the Schrodinger equations for them can be solved exactly only for certain limited parts of the spectrum, but not for the whole spectrum. They occupy an intermediate position between the exactly the authors solvable (ES) models and all the others. The number of energy levels for which the spectral problems can be solved exactly refer below to as the order of QES model. From the mathematical point of view the existence of QES models is not surprising. Indeed, if the term exact solvability expresses the possibility of total explicit diagonalization of infinite Hamiltonian matrix, then the term quasi-exact solvability implies the situation when the Hamiltonian matrix can be reduced explicitly to the block-diagonal form with one of the appearing blocks being finite

  3. Prepotential approach to exact and quasi-exact solvabilities

    International Nuclear Information System (INIS)

    Ho, C.-L.

    2008-01-01

    Exact and quasi-exact solvabilities of the one-dimensional Schroedinger equation are discussed from a unified viewpoint based on the prepotential together with Bethe ansatz equations. This is a constructive approach which gives the potential as well as the eigenfunctions and eigenvalues simultaneously. The novel feature of the present work is the realization that both exact and quasi-exact solvabilities can be solely classified by two integers, the degrees of two polynomials which determine the change of variable and the zeroth order prepotential. Most of the well-known exactly and quasi-exactly solvable models, and many new quasi-exactly solvable ones, can be generated by appropriately choosing the two polynomials. This approach can be easily extended to the constructions of exactly and quasi-exactly solvable Dirac, Pauli, and Fokker-Planck equations

  4. Class of exactly solvable scattering potentials in two dimensions, entangled-state pair generation, and a grazing-angle resonance effect

    Science.gov (United States)

    Loran, Farhang; Mostafazadeh, Ali

    2017-12-01

    We provide an exact solution of the scattering problem for the potentials of the form v (x ,y ) =χa(x ) [v0(x ) +v1(x ) ei α y] , where χa(x ) :=1 for x ∈[0 ,a ] , χa(x ) :=0 for x ∉[0 ,a ] , vj(x ) are real or complex-valued functions, χa(x ) v0(x ) is an exactly solvable scattering potential in one dimension, and α is a positive real parameter. If α exceeds the wave number k of the incident wave, the scattered wave does not depend on the choice of v1(x ) . In particular, v (x ,y ) is invisible if v0(x ) =0 and k α and v1(x ) ≠0 , the scattered wave consists of a finite number of coherent plane-wave pairs ψn± with wave vector: kn=(±√{k2-[nα ] 2 },n α ) , where n =0 ,1 ,2 ,...generating quantum states with a quantized component of momentum and pairs of states with an entangled momentum. We examine a realization of these potentials in terms of certain optical slabs. If k =N α for some positive integer N , ψN± coalesce and their amplitude diverge. If k exceeds N α slightly, ψN± have a much larger amplitude than ψn± with n

  5. g Algebra and two-dimensional quasiexactly solvable Hamiltonian ...

    Indian Academy of Sciences (India)

    Keywords. g2 algebra; quasiexactly solvable Hamiltonian; hidden algebra; Poschl–Teller potential. ... space of the polynomials, restricting to a linear transformation on this space, the associ- .... The operators L6 and L7 are the positive root.

  6. Solvable stochastic dealer models for financial markets

    Science.gov (United States)

    Yamada, Kenta; Takayasu, Hideki; Ito, Takatoshi; Takayasu, Misako

    2009-05-01

    We introduce solvable stochastic dealer models, which can reproduce basic empirical laws of financial markets such as the power law of price change. Starting from the simplest model that is almost equivalent to a Poisson random noise generator, the model becomes fairly realistic by adding only two effects: the self-modulation of transaction intervals and a forecasting tendency, which uses a moving average of the latest market price changes. Based on the present microscopic model of markets, we find a quantitative relation with market potential forces, which have recently been discovered in the study of market price modeling based on random walks.

  7. Exactly solvable birth and death processes

    International Nuclear Information System (INIS)

    Sasaki, Ryu

    2009-01-01

    Many examples of exactly solvable birth and death processes, a typical stationary Markov chain, are presented together with the explicit expressions of the transition probabilities. They are derived by similarity transforming exactly solvable 'matrix' quantum mechanics, which is recently proposed by Odake and the author [S. Odake and R. Sasaki, J. Math. Phys. 49, 053503 (2008)]. The (q-) Askey scheme of hypergeometric orthogonal polynomials of a discrete variable and their dual polynomials play a central role. The most generic solvable birth/death rates are rational functions of q x (with x being the population) corresponding to the q-Racah polynomial.

  8. Proton radioactivity with analytically solvable potential

    Indian Academy of Sciences (India)

    The multidimensional evolution of the system is reduced to one- dimensional case by ... Shi and Swiatecki [13] have shown that inclusion of the nuclear ... the Coulomb barrier such that it has a parabolic shape near its top. Guzmann et al.

  9. On polynormality in finite solvable groups

    CERN Document Server

    Mamadou-Sadialiou-Bah

    2003-01-01

    In the study of the arrangement of intermediate subgroups a wide use has been made of certain properties describing the way conjugacy classes of subgroups are embedded in the groups: abnormality, pronormality, paranormality, and their weak analogues. It was proved that pronormality and abnormality coincide with their weak analogues for solvable groups. This was a generalisation of known results of Peng and Taunt for finite solvable groups. In this paper we prove a conjecture of Borevich asserting a similar result for paranormality and polynormality (which is a sort of weak paranormality). Further we show that we get a stronger result when the given subgroup is nilpotent: In a finite solvable group any nilpotent polynormal subgroup is pronormal.

  10. On polynormality in finite solvable groups

    International Nuclear Information System (INIS)

    Mamadou Sadialiou Bah

    2003-05-01

    In the study of the arrangement of intermediate subgroups a wide use has been made of certain properties describing the way conjugacy classes of subgroups are embedded in the groups: abnormality, pronormality, paranormality, and their weak analogues. It was proved that pronormality and abnormality coincide with their weak analogues for solvable groups. This was a generalisation of known results of Peng and Taunt for finite solvable groups. In this paper we prove a conjecture of Borevich asserting a similar result for paranormality and polynormality (which is a sort of weak paranormality). Further we show that we get a stronger result when the given subgroup is nilpotent: In a finite solvable group any nilpotent polynormal subgroup is pronormal. (author)

  11. New quasi-exactly solvable Hermitian as well as non-Hermitian PT ...

    Indian Academy of Sciences (India)

    We start with quasi-exactly solvable (QES) Hermitian (and hence real) as well as complex P T -invariant, double sinh-Gordon potential and show that even after adding perturbation terms, the resulting potentials, in both cases, are still QES potentials. Further, by using anti-isospectral transformations, we obtain Hermitian as ...

  12. On solvability and integrability of the Rabi model

    International Nuclear Information System (INIS)

    Moroz, Alexander

    2013-01-01

    The quasi-exactly solvable Rabi model is investigated within the framework of the Bargmann Hilbert space of analytic functions B. On applying the theory of orthogonal polynomials, the eigenvalue equation and eigenfunctions are shown to be determined in terms of three systems of monic orthogonal polynomials. The formal Schweber quantization criterion for an energy variable x, originally expressed in terms of infinite continued fractions, can be recast in terms of a meromorphic function F(z)=a 0 +∑ k=1 ∞ M k /(z−ξ k ) in the complex plane C with real simple poles ξ k and positive residues M k . The zeros of F(x) on the real axis determine the spectrum of the Rabi model. One obtains at once that, on the real axis, (i) F(x) monotonically decreases from +∞ to −∞ between any two of its subsequent poles ξ k and ξ k+1 , (ii) there is exactly one zero of F(x) for x∈(ξ k ,ξ k+1 ), and (iii) the spectrum corresponding to the zeros of F(x) does not have any accumulation point. Additionally, one can provide a much simpler proof that the spectrum in each parity eigenspace B ± is necessarily nondegenerate. Thereby the calculation of spectra is greatly facilitated. Our results allow us to critically examine recent claims regarding solvability and integrability of the Rabi model. -- Highlights: •Schweber’s criterion shown equivalent to a meromorphic function F with real simple poles and positive residues. •Calculation of spectra determined as zeros of F greatly facilitated: one has exactly one zero between subsequent poles of F. •Spectrum in a given parity eigenspace is necessarily nondegenerate. •Recent claims regarding solvability and integrability of the Rabi model found to be largely unsubstantiated

  13. Perturbations of normally solvable nonlinear operators, I

    Directory of Open Access Journals (Sweden)

    William O. Ray

    1985-01-01

    Full Text Available Let X and Y be Banach spaces and let ℱ and be Gateaux differentiable mappings from X to Y In this note we study when the operator ℱ+ is surjective for sufficiently small perturbations of a surjective operator ℱ The methods extend previous results in the area of normal solvability for nonlinear operators.

  14. General Reducibility and Solvability of Polynomial Equations ...

    African Journals Online (AJOL)

    General Reducibility and Solvability of Polynomial Equations. ... Unlike quadratic, cubic, and quartic polynomials, the general quintic and higher degree polynomials cannot be solved algebraically in terms of finite number of additions, ... Galois Theory, Solving Polynomial Systems, Polynomial factorization, Polynomial Ring ...

  15. Child abduction murder: the impact of forensic evidence on solvability.

    Science.gov (United States)

    Brown, Katherine M; Keppel, Robert D

    2012-03-01

    This study examined 733 child abduction murders (CAMs) occurring from 1968 to 2002 to explore the influence of forensic evidence on case solvability in CAM investigations. It was hypothesized that the presence of forensic evidence connecting the offender to the crime would enhance case solvability in murder investigations of abducted children. This study examined the impact of CAM of different types of forensic evidence and the impact of the summed total of forensic evidence items on case solvability by controlling for victim age, victim race, victim gender, and victim-offender relationship. Time and distance theoretical predictors were also included. Binomial logistic regression models were used to determine whether forensic evidence was a critical solvability factor in murder investigations of abducted children. This research indicated that, while forensic evidence increased case solvability, the impact of forensic evidence on solvability was not as important as other solvability factors examined. © 2011 American Academy of Forensic Sciences.

  16. Harmonic analysis on exponential solvable Lie groups

    CERN Document Server

    Fujiwara, Hidenori

    2015-01-01

    This book is the first one that brings together recent results on the harmonic analysis of exponential solvable Lie groups. There still are many interesting open problems, and the book contributes to the future progress of this research field. As well, various related topics are presented to motivate young researchers. The orbit method invented by Kirillov is applied to study basic problems in the analysis on exponential solvable Lie groups. This method tells us that the unitary dual of these groups is realized as the space of their coadjoint orbits. This fact is established using the Mackey theory for induced representations, and that mechanism is explained first. One of the fundamental problems in the representation theory is the irreducible decomposition of induced or restricted representations. Therefore, these decompositions are studied in detail before proceeding to various related problems: the multiplicity formula, Plancherel formulas, intertwining operators, Frobenius reciprocity, and associated alge...

  17. Kovacs effect in solvable model glasses

    International Nuclear Information System (INIS)

    Aquino, Gerardo; Leuzzi, Luca; Nieuwenhuizen, Theo M

    2006-01-01

    The Kovacs protocol, based on the temperature shift experiment originally conceived by A.J. Kovacs and applied on glassy polymers, is implemented in an exactly solvable model with facilitated dynamics. This model is based on interacting fast and slow modes represented respectively by spherical spins and harmonic oscillator variables. Due to this fundamental property and to slow dynamics, the model reproduces the characteristic nonmonotonic evolution known as the 'Kovacs effect', observed in polymers, spin glasses, in granular materials and models of molecular liquids, when similar experimental protocols are implemented

  18. Kovacs effect in solvable model glasses

    Science.gov (United States)

    Aquino, Gerardo; Leuzzi, Luca; Nieuwenhuizen, Theo M.

    2006-05-01

    The Kovacs protocol, based on the temperature shift experiment originally conceived by A.J. Kovacs and applied on glassy polymers [1], is implemented in an exactly solvable model with facilitated dynamics. This model is based on interacting fast and slow modes represented respectively by spherical spins and harmonic oscillator variables. Due to this fundamental property and to slow dynamics, the model reproduces the characteristic nonmonotonic evolution known as the ''Kovacs effect'', observed in polymers, spin glasses, in granular materials and models of molecular liquids, when similar experimental protocols are implemented.

  19. Reliability and extended-life potential of EBR-II

    International Nuclear Information System (INIS)

    King, R.W.

    1985-01-01

    Although the longlife potential of liquid-metal-cooled reactors (LMRs) has been only partially demonstrated, many factors point to the potential for exceptionally long life. EBR-II has the opportunity to become the first LMR to achieve an operational lifetime of 30 years or more. In 1984 a study of the extended-life potential of EBR-II identified the factors that contribute to the continued successful operation of EBR-II as a power reactor and experimental facility. Also identified were factors that could cause disruptions in the useful life of the facility. Although no factors were found that would inherently limit the life of EBR-II, measures were identified that could help ensure continued plant availability. These measures include the implementation of more effective surveillance, diagnostic, and control systems to complement the inherent safety and reliability features of EBR-II. An operating lifetime of well beyond 30 years is certainly feasible

  20. Geometrical aspects of solvable two dimensional models

    International Nuclear Information System (INIS)

    Tanaka, K.

    1989-01-01

    It was noted that there is a connection between the non-linear two-dimensional (2D) models and the scalar curvature r, i.e., when r = -2 the equations of motion of the Liouville and sine-Gordon models were obtained. Further, solutions of various classical nonlinear 2D models can be obtained from the condition that the appropriate curvature two form Ω = 0, which suggests that these models are closely related. This relation is explored further in the classical version by obtaining the equations of motion from the evolution equations, the infinite number of conserved quantities, and the common central charge. The Poisson brackets of the solvable 2D models are specified by the Virasoro algebra. 21 refs

  1. GEOMETRIZATION OF NONHOLONOMIC MECHANICAL SYSTEMS AND THEIR SOLVABILITY

    Institute of Scientific and Technical Information of China (English)

    慕小武; 郭仲衡

    1990-01-01

    A new geometrization approach to nonholonomic mechanical systems is proposed and a series of solvability conditions under the proposed geometric frame are given. The proposed frame differs essentially from Hermann’s. The limitations of Hermann’s frame are also discussed. It is shown that a system under Hermann’s frame is solvable only if its constraints are given by natural conservation laws of the corresponding constraint-free system.

  2. Synthesis and structure of copper(II) complexes: Potential cyanide ...

    Indian Academy of Sciences (India)

    easy accessibility to Cu(I), Cu(II) and Cu(III) oxidation states.3,20–38 ... erty to oxidize primary alcohol to aldehyde since they are potential N,O ... Electronic spectra were recorded on a. Shimadzu .... the appropriate temperature 37. ◦. C for 24h.

  3. Multichannel coupling with supersymmetric quantum mechanics and exactly-solvable model for the Feshbach resonance

    International Nuclear Information System (INIS)

    Sparenberg, Jean-Marc; Samsonov, Boris F; Foucart, Francois; Baye, Daniel

    2006-01-01

    A new type of supersymmetric transformations of the coupled-channel radial Schroedinger equation is introduced, which do not conserve the vanishing behaviour of solutions at the origin. Contrary to the usual transformations, these 'non-conservative' transformations allow, in the presence of thresholds, the construction of well-behaved potentials with coupled scattering matrices from uncoupled potentials. As an example, an exactly-solvable potential matrix is obtained which provides a very simple model of the Feshbach-resonance phenomenon. (letter to the editor)

  4. Exactly and quasi-exactly solvable 'discrete' quantum mechanics.

    Science.gov (United States)

    Sasaki, Ryu

    2011-03-28

    A brief introduction to discrete quantum mechanics is given together with the main results on various exactly solvable systems. Namely, the intertwining relations, shape invariance, Heisenberg operator solutions, annihilation/creation operators and dynamical symmetry algebras, including the q-oscillator algebra and the Askey-Wilson algebra. A simple recipe to construct exactly and quasi-exactly solvable (QES) Hamiltonians in one-dimensional 'discrete' quantum mechanics is presented. It reproduces all the known Hamiltonians whose eigenfunctions consist of the Askey scheme of hypergeometric orthogonal polynomials of a continuous or a discrete variable. Several new exactly and QES Hamiltonians are constructed. The sinusoidal coordinate plays an essential role.

  5. A note on unique solvability of the absolute value equation

    Directory of Open Access Journals (Sweden)

    Taher Lotfi

    2014-05-01

    Full Text Available It is proved that applying sufficient regularity conditions to the interval matrix $[A-|B|,A+|B|]$‎, ‎we can create a new unique solvability condition for the absolute value equation $Ax+B|x|=b$‎, ‎since regularity of interval matrices implies unique solvability of their corresponding absolute value equation‎. ‎This condition is formulated in terms of positive definiteness of a certain point matrix‎. ‎Special case $B=-I$ is verified too as an application.

  6. Quasi exactly solvable operators and abstract associative algebras

    International Nuclear Information System (INIS)

    Brihaye, Y.; Kosinski, P.

    1998-01-01

    We consider the vector spaces consisting of direct sums of polynomials of given degrees and we show how to classify the linear differential operators preserving these spaces. The families of operators so obtained are identified as the envelopping algebras of particular abstract associative algebras. Some of these operators can be transformed into quasi exactly solvable Schroedinger operators which, having a hidden algebra, can be partially solved algebraically; we exhibit however a series of Schoedinger equations which, while completely solvable algebraically, do not possess a hidden algebra

  7. A Solvable Model for Nuclear Shape Phase Transitions

    International Nuclear Information System (INIS)

    Levai, G.; Arias, J. M.

    2009-01-01

    There has been considerable interest recently in phase transitions that occur between some well-defined nuclear shapes, e.g. the spherical vibrator, the axially deformed rotor and the γ-unstable rotor, which are assigned to the U(5), SU(3) and 0(6) symmetries. These shape phase transitions occur through critical points of the IBM phase diagram and correspond to rapid structural changes. The first transition of this type describes transition form the spherical to the γ-unstable phase and has been associated with an E(5) symmetry. Later further critical point symmetries e.g. X(5) and Y(5) have also been proposed for transitions between other nuclear shape phases. In another application the chain of even Ru isotopes was considered from A 98 to 112 [2]. The parameters were extracted from a fit to the low-lying energy spectrum of each nucleus and were used to plot the corresponding potential. It was found that up to A =102 the potential is essentially an harmonic oscillator, while at A =104 a rather flat potential was seen, in accordance with the expected phase transition and E(5) symmetry there. With increasing A then the minimum got increasingly deeper and moved away from β = 0. We discuss the possibility of generalizing the formalism in two ways: first by including dependence on the 7 variable allowing for the approximate description of nuclei close to the X(5) symmetry, and second, including higher-lying energy levels in the quasi-exactly solvable formalism

  8. Fragments of reminiscences and exactly solvable nonrelativistic quantum models

    International Nuclear Information System (INIS)

    Zakhariev, B.N.

    1994-01-01

    Some exactly solvable nonrelativistic quantum models are discussed. Special attention is paid to the quantum inverse problem. It is pointed out that by analyzing the inverse problem pictures one can get a deeper insight into the laws of the microworld and acquire the ability to make the qualitative predictions without computers and formulae. 5 refs

  9. Global solvability for involutive systems on the torus

    Directory of Open Access Journals (Sweden)

    Cleber de Medeira

    2013-11-01

    Full Text Available In this article, we consider a class of involutive systems of n smooth vector fields on the torus of dimension n+1. We prove that the global solvability of this class is related to an algebraic condition involving Liouville forms and the connectedness of all sublevel and superlevel sets of the primitive of a certain 1-form associated with the system.

  10. Solvable Model for Dynamic Mass Transport in Disordered Geophysical Media

    KAUST Repository

    Marder, M.; Eftekhari, Behzad; Patzek, Tadeusz

    2018-01-01

    We present an analytically solvable model for transport in geophysical materials on large length and time scales. It describes the flow of gas to a complicated absorbing boundary over long periods of time. We find a solution to this model using Green's function techniques, and apply the solution to three absorbing networks of increasing complexity.

  11. Continual Lie algebras and noncommutative counterparts of exactly solvable models

    Science.gov (United States)

    Zuevsky, A.

    2004-01-01

    Noncommutative counterparts of exactly solvable models are introduced on the basis of a generalization of Saveliev-Vershik continual Lie algebras. Examples of noncommutative Liouville and sin/h-Gordon equations are given. The simplest soliton solution to the noncommutative sine-Gordon equation is found.

  12. Classification of non-solvable groups with a given property

    Indian Academy of Sciences (India)

    In this paper, we classify the finite non-solvable groups satisfying the following property P5: their orders of representatives are set-wise relatively prime for any 5 distinct non-central conjugacy classes. Keywords. Conjugacy classes; graph; Frobenius group; order. 2010 Mathematics Subject Classification. 20D60, 20E45. 1.

  13. Classification of non-solvable groups with a given property

    Indian Academy of Sciences (India)

    In this paper, we classify the finite non-solvable groups satisfying the following property P 5 : their orders of representatives are set-wise relatively prime for any 5 distinct non-central conjugacy classes. Author Affiliations. Zeinab Foruzanfar1 Zohreh Mostaghim1. School of Mathematics, Iran University of Science and ...

  14. Explicitly solvable complex Chebyshev approximation problems related to sine polynomials

    Science.gov (United States)

    Freund, Roland

    1989-01-01

    Explicitly solvable real Chebyshev approximation problems on the unit interval are typically characterized by simple error curves. A similar principle is presented for complex approximation problems with error curves induced by sine polynomials. As an application, some new explicit formulae for complex best approximations are derived.

  15. Super Virasoro algebra and solvable supersymmetric quantum field theories

    International Nuclear Information System (INIS)

    Yamanaka, Itaru; Sasaki, Ryu.

    1987-09-01

    Interesting and deep relationships between super Virasoro algebras and super soliton systems (super KdV, super mKdV and super sine-Gordon equations) are investigated at both classical and quantum levels. An infinite set of conserved quantities responsible for solvability is characterized by super Virasoro algebras only. Several members of the infinite set of conserved quantities are derived explicitly. (author)

  16. Analytically solvable models of reaction-diffusion systems

    Energy Technology Data Exchange (ETDEWEB)

    Zemskov, E P; Kassner, K [Institut fuer Theoretische Physik, Otto-von-Guericke-Universitaet, Universitaetsplatz 2, 39106 Magdeburg (Germany)

    2004-05-01

    We consider a class of analytically solvable models of reaction-diffusion systems. An analytical treatment is possible because the nonlinear reaction term is approximated by a piecewise linear function. As particular examples we choose front and pulse solutions to illustrate the matching procedure in the one-dimensional case.

  17. Solvable Model for Dynamic Mass Transport in Disordered Geophysical Media

    KAUST Repository

    Marder, M.

    2018-03-29

    We present an analytically solvable model for transport in geophysical materials on large length and time scales. It describes the flow of gas to a complicated absorbing boundary over long periods of time. We find a solution to this model using Green\\'s function techniques, and apply the solution to three absorbing networks of increasing complexity.

  18. Three-body problem in d-dimensional space: Ground state, (quasi)-exact-solvability

    Science.gov (United States)

    Turbiner, Alexander V.; Miller, Willard; Escobar-Ruiz, M. A.

    2018-02-01

    As a straightforward generalization and extension of our previous paper [A. V. Turbiner et al., "Three-body problem in 3D space: Ground state, (quasi)-exact-solvability," J. Phys. A: Math. Theor. 50, 215201 (2017)], we study the aspects of the quantum and classical dynamics of a 3-body system with equal masses, each body with d degrees of freedom, with interaction depending only on mutual (relative) distances. The study is restricted to solutions in the space of relative motion which are functions of mutual (relative) distances only. It is shown that the ground state (and some other states) in the quantum case and the planar trajectories (which are in the interaction plane) in the classical case are of this type. The quantum (and classical) Hamiltonian for which these states are eigenfunctions is derived. It corresponds to a three-dimensional quantum particle moving in a curved space with special d-dimension-independent metric in a certain d-dependent singular potential, while at d = 1, it elegantly degenerates to a two-dimensional particle moving in flat space. It admits a description in terms of pure geometrical characteristics of the interaction triangle which is defined by the three relative distances. The kinetic energy of the system is d-independent; it has a hidden sl(4, R) Lie (Poisson) algebra structure, alternatively, the hidden algebra h(3) typical for the H3 Calogero model as in the d = 3 case. We find an exactly solvable three-body S3-permutationally invariant, generalized harmonic oscillator-type potential as well as a quasi-exactly solvable three-body sextic polynomial type potential with singular terms. For both models, an extra first order integral exists. For d = 1, the whole family of 3-body (two-dimensional) Calogero-Moser-Sutherland systems as well as the Tremblay-Turbiner-Winternitz model is reproduced. It is shown that a straightforward generalization of the 3-body (rational) Calogero model to d > 1 leads to two primitive quasi

  19. Higgs potential in the type II seesaw model

    International Nuclear Information System (INIS)

    Arhrib, A.; Benbrik, R.; Chabab, M.; Rahili, L.; Ramadan, J.; Moultaka, G.; Peyranere, M. C.

    2011-01-01

    The standard model Higgs sector, extended by one weak gauge triplet of scalar fields with a very small vacuum expectation value, is a very promising setting to account for neutrino masses through the so-called type II seesaw mechanism. In this paper we consider the general renormalizable doublet/triplet Higgs potential of this model. We perform a detailed study of its main dynamical features that depend on five dimensionless couplings and two mass parameters after spontaneous symmetry breaking, and highlight the implications for the Higgs phenomenology. In particular, we determine (i) the complete set of tree-level unitarity constraints on the couplings of the potential and (ii) the exact tree-level boundedness from below constraints on these couplings, valid for all directions. When combined, these constraints delineate precisely the theoretically allowed parameter space domain within our perturbative approximation. Among the seven physical Higgs states of this model, the mass of the lighter (heavier) CP even state h 0 (H 0 ) will always satisfy a theoretical upper (lower) bound that is reached for a critical value μ c of μ (the mass parameter controlling triple couplings among the doublet/triplet Higgses). Saturating the unitarity bounds, we find an upper bound m h 0 or approx. μ c and μ c . In the first regime the Higgs sector is typically very heavy, and only h 0 that becomes SM-like could be accessible to the LHC. In contrast, in the second regime, somewhat overlooked in the literature, most of the Higgs sector is light. In particular, the heaviest state H 0 becomes SM-like, the lighter states being the CP odd Higgs, the (doubly) charged Higgses, and a decoupled h 0 , possibly leading to a distinctive phenomenology at the colliders.

  20. Application of the adiabatic self-consistent collective coordinate method to a solvable model of prolate-oblate shape coexistence

    International Nuclear Information System (INIS)

    Kobayasi, Masato; Matsuyanagi, Kenichi; Nakatsukasa, Takashi; Matsuo, Masayuki

    2003-01-01

    The adiabatic self-consistent collective coordinate method is applied to an exactly solvable multi-O(4) model that is designed to describe nuclear shape coexistence phenomena. The collective mass and dynamics of large amplitude collective motion in this model system are analyzed, and it is shown that the method yields a faithful description of tunneling motion through a barrier between the prolate and oblate local minima in the collective potential. The emergence of the doublet pattern is clearly described. (author)

  1. Generalization of quasi-exactly solvable and isospectral potentials

    Indian Academy of Sciences (India)

    A unified approach in the light of supersymmetric quantum mechanics ..... show that the lowest energy level of H lies at the ground state of H1. ...... [16] M Kaplus and R N Porter, Atoms and molecular physics (Cambridge University Press,.

  2. Exactly solvable models in many-body theory

    CERN Document Server

    March, N H

    2016-01-01

    The book reviews several theoretical, mostly exactly solvable, models for selected systems in condensed states of matter, including the solid, liquid, and disordered states, and for systems of few or many bodies, both with boson, fermion, or anyon statistics. Some attention is devoted to models for quantum liquids, including superconductors and superfluids. Open problems in relativistic fields and quantum gravity are also briefly reviewed.The book ranges almost comprehensively, but concisely, across several fields of theoretical physics of matter at various degrees of correlation and at different energy scales, with relevance to molecular, solid-state, and liquid-state physics, as well as to phase transitions, particularly for quantum liquids. Mostly exactly solvable models are presented, with attention also to their numerical approximation and, of course, to their relevance for experiments.

  3. Some solvable, and as yet unsolvable, polygon and walk models

    International Nuclear Information System (INIS)

    Guttmann, Anthony J

    2006-01-01

    One partly solvable and two solvable models of polygons are discussed. Using a simple transfer matrix approach Iwan Jensen has derived very long series expansions for the perimeter generating function of both three-choice polygons and punctured staircase polygons. In both cases it is found that all the terms in the generating function can be reproduced from a linear Fuchsian differential equation of order 8. We report on an analysis of the properties of the differential equations. Recently Enrica Duchi has discussed the problem of so-called prudent self-avoiding walks. We discuss the polygon analogue of this problem, and argue that the generating function for prudent polygons is unlikely to be differentiably finite, though a restricted version of the problem, called prudent polygons of the second type, is likely to be differentiably finite. The exact generating function for prudent polygons of the first type is also found

  4. New analytically solvable models of relativistic point interactions

    International Nuclear Information System (INIS)

    Gesztesy, F.; Seba, P.

    1987-01-01

    Two new analytically solvable models of relativistic point interactions in one dimension (being natural extensions of the nonrelativistic δ-resp, δ'-interaction) are considered. Their spectral properties in the case of finitely many point interactions as well as in the periodic case are fully analyzed. Moreover the spectrum is explicitely determined in the case of independent, identically distributed random coupling constants and the analog of the Saxon and Huther conjecture concerning gaps in the energy spectrum of such systems is derived

  5. Two solvable problems of planar geometrical optics.

    Science.gov (United States)

    Borghero, Francesco; Bozis, George

    2006-12-01

    In the framework of geometrical optics we consider a two-dimensional transparent inhomogeneous isotropic medium (dispersive or not). We show that (i) for any family belonging to a certain class of planar monoparametric families of monochromatic light rays given in the form f(x,y)=c of any definite color and satisfying a differential condition, all the refractive index profiles n=n(x,y) allowing for the creation of the given family can be found analytically (inverse problem) and that (ii) for any member of a class of two-dimensional refractive index profiles n=n(x,y) satisfying a differential condition, all the compatible families of light rays can be found analytically (direct problem). We present appropriate examples.

  6. Re-modeling Chara action potential: II. The action potential form under salinity stress

    Directory of Open Access Journals (Sweden)

    Mary Jane Beilby

    2017-04-01

    Full Text Available In part I we established Thiel-Beilby model of the Chara action potential (AP. In part II the AP is investigated in detail at the time of saline stress. Even very short exposure of salt-sensitive Chara cells to artificial pond water with 50 mM NaCl (Saline APW modified the AP threshold and drastically altered the AP form. Detailed modeling of 14 saline APs from 3 cells established that both the Ca2+ pump and the Ca2+ channels on internal stores seem to be affected, with the changes sometimes cancelling and sometimes re-enforcing each other, leading to APs with long durations and very complex forms. The exposure to salinity offers further insights into AP mechanism and suggests future experiments. The prolonged APs lead to greater loss of chloride and potassium ions, compounding the effects of saline stress.

  7. A quasi-exactly solvable Lipkin-Meshkov-Glick model

    International Nuclear Information System (INIS)

    Pan Feng; Lin Jijie; Xue Xiaogang; Draayer, J P

    2010-01-01

    We prove that a special Lipkin-Meshkov-Glick model is quasi-exactly solvable with solutions that can be expressed in the SU(2) coherent state form. Ground-state properties of the model are studied analytically. We also show that the model reduces to the standard two-site Bose-Hubbard model in the large-N limit for finite U/t or large (N - 1)|U|/t cases with finite N, which proves that in these cases the ground state of the standard two-site Bose-Hubbard model is an SU(2) coherent state.

  8. On the evolution equations, solvable through the inverse scattering method

    International Nuclear Information System (INIS)

    Gerdjikov, V.S.; Khristov, E.Kh.

    1979-01-01

    The nonlinear evolution equations (NLEE), related to the one-parameter family of Dirac operators are considered in a uniform manner. The class of NLEE solvable through the inverse scatterina method and their conservation laws are described. The description of the hierarchy of Hamiltonian structures and the proof of complete integrability of the NLEE is presented. The class of Baecklund transformations for these NLEE is derived. The general formulae are illustrated by two important examples: the nonlinear Schroedinger equation and the sine-Gordon equation

  9. Exactly solvable string models of curved space-time backgrounds

    International Nuclear Information System (INIS)

    Russo, J.G.

    1995-01-01

    We consider a new 3-parameter class of exact 4-dimensional solutions in closed string theory and solve the corresponding string model, determining the physical spectrum and the partition function. The background fields (4-metric, antisymmetric tensor, two Kaluza-Klein vector fields, dilaton and modulus) generically describe axially symmetric stationary rotating (electro)magnetic flux-tube type universes. Backgrounds of this class include both the ''dilatonic'' (a=1) and ''Kaluza-Klein'' (a=√(3)) Melvin solutions and the uniform magnetic field solution, as well as some singular space-times. Solvability of the string σ-model is related to its connection via duality to a simpler model which is a ''twisted'' product of a flat 2-space and a space dual to 2-plane. We discuss some physical properties of this model (tachyonic instabilities in the spectrum, gyromagnetic ratio, issue of singularities, etc.). It provides one of the first examples of a consistent solvable conformal string model with explicit D=4 curved space-time interpretation. (orig.)

  10. Potential Clinical Implications of the Urotensin II Receptor Antagonists

    Directory of Open Access Journals (Sweden)

    Emilie Kane

    2011-07-01

    Full Text Available Urotensin-II (UII, which binds to its receptor UT, plays an important role in the heart, kidneys, pancreas, adrenal gland and CNS. In the vasculature, it acts as a potent endothelium-independent vasoconstrictor and endothelium-dependent vasodilator. In disease states, this constriction-dilation equilibrium is disrupted. There is an upregulation of the UII system in heart disease, metabolic syndrome and kidney failure. The increase in UII release and UT expression suggest that UII system may be implicated in the pathology and pathogenesis of these diseases by causing an increase in ACAT-1 activity leading to SMC proliferation and foam cell infiltration, insulin resistance (DMII, as well as inflammation, high blood pressure and plaque formation. Recently, UT antagonists such as SB-611812, palosuran, and most recently a piperazino-isoindolinone based antagonist have been developed in the hope of better understanding the UII system and treating its associated diseases.

  11. SUSY formalism for the symmetric double well potential

    Indian Academy of Sciences (India)

    symmetric double well potential barrier we have obtained a class of exactly solvable potentials subject to moving boundary condition. The eigenstates are also obtained by the same technique. Keywords. SUSY; moving boundary condition; exactly solvable; symmetric double well; NH3 molecule. PACS Nos 02.30.Ik; 03.50.

  12. Isospectrality of conventional and new extended potentials, second ...

    Indian Academy of Sciences (India)

    Exact solvability; supersymmetry; PT symmetry; rational potentials. PACS Nos 03.65.Fd; 03.65.Ge. 1. Introduction. The search for exactly solvable potentials has been a subject of intense research ... A + 1 > 1 but supports a finite number of bound states, whose energies are given by ..... where ¯c is some integration constant.

  13. Solvable Family of Driven-Dissipative Many-Body Systems

    Science.gov (United States)

    Foss-Feig, Michael; Young, Jeremy T.; Albert, Victor V.; Gorshkov, Alexey V.; Maghrebi, Mohammad F.

    2017-11-01

    Exactly solvable models have played an important role in establishing the sophisticated modern understanding of equilibrium many-body physics. Conversely, the relative scarcity of solutions for nonequilibrium models greatly limits our understanding of systems away from thermal equilibrium. We study a family of nonequilibrium models, some of which can be viewed as dissipative analogues of the transverse-field Ising model, in that an effectively classical Hamiltonian is frustrated by dissipative processes that drive the system toward states that do not commute with the Hamiltonian. Surprisingly, a broad and experimentally relevant subset of these models can be solved efficiently. We leverage these solutions to compute the effects of decoherence on a canonical trapped-ion-based quantum computation architecture, and to prove a no-go theorem on steady-state phase transitions in a many-body model that can be realized naturally with Rydberg atoms or trapped ions.

  14. Exactly solvable string models of curved space-time backgrounds

    CERN Document Server

    Russo, J.G.; Russo, J G; Tseytlin, A A

    1995-01-01

    We consider a new 3-parameter class of exact 4-dimensional solutions in closed string theory and solve the corresponding string model, determining the physical spectrum and the partition function. The background fields (4-metric, antisymmetric tensor, two Kaluza-Klein vector fields, dilaton and modulus) generically describe axially symmetric stationary rotating (electro)magnetic flux-tube type universes. Backgrounds of this class include both the dilatonic Melvin solution and the uniform magnetic field solution discussed earlier as well as some singular space-times. Solvability of the string sigma model is related to its connection via duality to a much simpler looking model which is a "twisted" product of a flat 2-space and a space dual to 2-plane. We discuss some physical properties of this model as well as a number of generalizations leading to larger classes of exact 4-dimensional string solutions.

  15. Dolan Grady relations and noncommutative quasi-exactly solvable systems

    Science.gov (United States)

    Klishevich, Sergey M.; Plyushchay, Mikhail S.

    2003-11-01

    We investigate a U(1) gauge invariant quantum mechanical system on a 2D noncommutative space with coordinates generating a generalized deformed oscillator algebra. The Hamiltonian is taken as a quadratic form in gauge covariant derivatives obeying the nonlinear Dolan-Grady relations. This restricts the structure function of the deformed oscillator algebra to a quadratic polynomial. The cases when the coordinates form the {\\mathfrak{su}}(2) and {\\mathfrak{sl}}(2,{\\bb {R}}) algebras are investigated in detail. Reducing the Hamiltonian to 1D finite-difference quasi-exactly solvable operators, we demonstrate partial algebraization of the spectrum of the corresponding systems on the fuzzy sphere and noncommutative hyperbolic plane. A completely covariant method based on the notion of intrinsic algebra is proposed to deal with the spectral problem of such systems.

  16. Demonstration of Detection and Ranging Using Solvable Chaos

    Science.gov (United States)

    Corron, Ned J.; Stahl, Mark T.; Blakely, Jonathan N.

    2013-01-01

    Acoustic experiments demonstrate a novel approach to ranging and detection that exploits the properties of a solvable chaotic oscillator. This nonlinear oscillator includes an ordinary differential equation and a discrete switching condition. The chaotic waveform generated by this hybrid system is used as the transmitted waveform. The oscillator admits an exact analytic solution that can be written as the linear convolution of binary symbols and a single basis function. This linear representation enables coherent reception using a simple analog matched filter and without need for digital sampling or signal processing. An audio frequency implementation of the transmitter and receiver is described. Successful acoustic ranging measurements are presented to demonstrate the viability of the approach.

  17. An Exactly Solvable Supersymmetric Model of Semimagic Nuclei

    International Nuclear Information System (INIS)

    Balantekin, A. B.; Gueven, Nurtac; Pehlivan, Yamac

    2008-01-01

    A simple model of nucleons coupled to angular momentum zero (s-pairs) occupying the valance shell of a semi-magic nuclei is considered. The model has a separable, orbit dependent pairing interaction which dominates over the kinetic term. It is shown that such an interaction leads to an exactly solvable model whose (0 + ) eigenstates and energies can be computed very easily with the help of the algebraic Bethe ansatz method. It is also shown that the model has a supersymmetry which connects the spectra of some semimagic nuclei. The results obtained from this model for the semimagic Ni isotopes from 58 Ni to 68 Ni are given. In addition, a new and easier technique for calculating the energy eigenvalues from the Bethe ansatz equations is also presented.

  18. A New Class of Solvable Many-Body Problems

    Directory of Open Access Journals (Sweden)

    Francesco Calogero

    2012-10-01

    Full Text Available A new class of solvable N-body problems is identified. They describe N unit-mass point particles whose time-evolution, generally taking place in the complex plane, is characterized by Newtonian equations of motion ''of goldfish type'' (acceleration equal force, with specific velocity-dependent one-body and two-body forces featuring several arbitrary coupling constants. The corresponding initial-value problems are solved by finding the eigenvalues of a time-dependent N×N matrix U(t explicitly defined in terms of the initial positions and velocities of the N particles. Some of these models are asymptotically isochronous, i.e. in the remote future they become completely periodic with a period T independent of the initial data (up to exponentially vanishing corrections. Alternative formulations of these models, obtained by changing the dependent variables from the N zeros of a monic polynomial of degree N to its N coefficients, are also exhibited.

  19. Topological order in an exactly solvable 3D spin model

    International Nuclear Information System (INIS)

    Bravyi, Sergey; Leemhuis, Bernhard; Terhal, Barbara M.

    2011-01-01

    Research highlights: RHtriangle We study exactly solvable spin model with six-qubit nearest neighbor interactions on a 3D face centered cubic lattice. RHtriangle The ground space of the model exhibits topological quantum order. RHtriangle Elementary excitations can be geometrically described as the corners of rectangular-shaped membranes. RHtriangle The ground space can encode 4g qubits where g is the greatest common divisor of the lattice dimensions. RHtriangle Logical operators acting on the encoded qubits are described in terms of closed strings and closed membranes. - Abstract: We study a 3D generalization of the toric code model introduced recently by Chamon. This is an exactly solvable spin model with six-qubit nearest-neighbor interactions on an FCC lattice whose ground space exhibits topological quantum order. The elementary excitations of this model which we call monopoles can be geometrically described as the corners of rectangular-shaped membranes. We prove that the creation of an isolated monopole separated from other monopoles by a distance R requires an operator acting on Ω(R 2 ) qubits. Composite particles that consist of two monopoles (dipoles) and four monopoles (quadrupoles) can be described as end-points of strings. The peculiar feature of the model is that dipole-type strings are rigid, that is, such strings must be aligned with face-diagonals of the lattice. For periodic boundary conditions the ground space can encode 4g qubits where g is the greatest common divisor of the lattice dimensions. We describe a complete set of logical operators acting on the encoded qubits in terms of closed strings and closed membranes.

  20. Macrocyclic receptor showing extremely high Sr(II)/Ca(II) and Pb(II)/Ca(II) selectivities with potential application in chelation treatment of metal intoxication.

    Science.gov (United States)

    Ferreirós-Martínez, Raquel; Esteban-Gómez, David; Tóth, Éva; de Blas, Andrés; Platas-Iglesias, Carlos; Rodríguez-Blas, Teresa

    2011-04-18

    Herein we report a detailed investigation of the complexation properties of the macrocyclic decadentate receptor N,N'-Bis[(6-carboxy-2-pyridil)methyl]-4,13-diaza-18-crown-6 (H(2)bp18c6) toward different divalent metal ions [Zn(II), Cd(II), Pb(II), Sr(II), and Ca(II)] in aqueous solution. We have found that this ligand is especially suited for the complexation of large metal ions such as Sr(II) and Pb(II), which results in very high Pb(II)/Ca(II) and Pb(II)/Zn(II) selectivities (in fact, higher than those found for ligands widely used for the treatment of lead poisoning such as ethylenediaminetetraacetic acid (edta)), as well as in the highest Sr(II)/Ca(II) selectivity reported so far. These results have been rationalized on the basis of the structure of the complexes. X-ray crystal diffraction, (1)H and (13)C NMR spectroscopy, as well as theoretical calculations at the density functional theory (B3LYP) level have been performed. Our results indicate that for large metal ions such as Pb(II) and Sr(II) the most stable conformation is Δ(δλδ)(δλδ), while for Ca(II) our calculations predict the Δ(λδλ)(λδλ) form being the most stable one. The selectivity that bp18c6(2-) shows for Sr(II) over Ca(II) can be attributed to a better fit between the large Sr(II) ions and the relatively large crown fragment of the ligand. The X-ray crystal structure of the Pb(II) complex shows that the Δ(δλδ)(δλδ) conformation observed in solution is also maintained in the solid state. The Pb(II) ion is endocyclically coordinated, being directly bound to the 10 donor atoms of the ligand. The bond distances to the donor atoms of the pendant arms (2.55-2.60 Å) are substantially shorter than those between the metal ion and the donor atoms of the crown moiety (2.92-3.04 Å). This is a typical situation observed for the so-called hemidirected compounds, in which the Pb(II) lone pair is stereochemically active. The X-ray structures of the Zn(II) and Cd(II) complexes show that

  1. Diatomic-molecule vibrational potentials. II. New representationsa)

    International Nuclear Information System (INIS)

    Engelke, R.

    1979-01-01

    Two new representations of diatomic-molecule vibrational potentials are presented. One of these includes most of the previously employed series approximations as special cases. The new representations are tested against older ones by using Peek's ''exact'' numerical Born--Oppenheimer potentials for the 1ssigma/sub g/, 2pπ/sub u/, and 3dsigma/sub g/ states of H 2 + as test problems. Accuracy comparisons are made with Dunham, Thakkar, Ogilvie--Tipping, Coulomb-subtracted Ogilvie--Tipping, and Pade representations. A central idea of the new treatment is that it is not necessary to use a global representation of the potential over the region 0 or =1 and then match them smoothly to each other and to the Dunham expansion at R/R/sub e/=1. Attention is focused on finding improved approximations for R/R/sub e/>1, since this region exerts strong control on the vibrational eigenvalue spectrum and it is here, perhaps, where the older techniques are at their weakest. Known properties of the exact potential such as the R→infinity behavior and the dissociation energy can be built into the new forms a priori. If the dissociation energy is not known, the new methods allow it to be estimated with better accuracy then could be done previously. If one knows only Dunham coefficients, the Coulomb-subtracted Ogilvie--Tipping series is the superior representation. If one knows, in addition, the dissociation energy, the new representations are superior and give more accurate results on the interval R/R/sub e/> or =1

  2. Simple inflationary quintessential model. II. Power law potentials

    Science.gov (United States)

    de Haro, Jaume; Amorós, Jaume; Pan, Supriya

    2016-09-01

    The present work is a sequel of our previous work [Phys. Rev. D 93, 084018 (2016)] which depicted a simple version of an inflationary quintessential model whose inflationary stage was described by a Higgs-type potential and the quintessential phase was responsible due to an exponential potential. Additionally, the model predicted a nonsingular universe in past which was geodesically past incomplete. Further, it was also found that the model is in agreement with the Planck 2013 data when running is allowed. But, this model provides a theoretical value of the running which is far smaller than the central value of the best fit in ns , r , αs≡d ns/d l n k parameter space where ns, r , αs respectively denote the spectral index, tensor-to-scalar ratio and the running of the spectral index associated with any inflationary model, and consequently to analyze the viability of the model one has to focus in the two-dimensional marginalized confidence level in the allowed domain of the plane (ns,r ) without taking into account the running. Unfortunately, such analysis shows that this model does not pass this test. However, in this sequel we propose a family of models runs by a single parameter α ∈[0 ,1 ] which proposes another "inflationary quintessential model" where the inflation and the quintessence regimes are respectively described by a power law potential and a cosmological constant. The model is also nonsingular although geodesically past incomplete as in the cited model. Moreover, the present one is found to be more simple compared to the previous model and it is in excellent agreement with the observational data. In fact, we note that, unlike the previous model, a large number of the models of this family with α ∈[0 ,1/2 ) match with both Planck 2013 and Planck 2015 data without allowing the running. Thus, the properties in the current family of models compared to its past companion justify its need for a better cosmological model with the successive

  3. Membrane potential and ion transport in lung epithelial type II cells

    International Nuclear Information System (INIS)

    Gallo, R.L.

    1986-01-01

    The alveolar type II pneumocyte is critically important to the function and maintenance of pulmonary epithelium. To investigate the nature of the response of type II cells to membrane injury, and describe a possible mechanism by which these cells regulate surfactant secretion, the membrane potential of isolated rabbit type II cells was characterized. This evaluation was accomplished by measurements of the accumulation of the membrane potential probes: [ 3 H]triphenylmethylphosphonium ([ 3 H]TPMP + ), rubidium 86, and the fluorescent dye DiOC 5 . A compartmental analysis of probe uptake into mitochondrial, cytoplasmic, and non-membrane potential dependent stores was made through the use of selective membrane depolarizations with carbonycyanide M-chlorophenylhydrazone (CCCP), and lysophosphatidylcholine (LPC). These techniques and population analysis with flow cytometry, permitted the accurate evaluation of type II cell membrane potential under control conditions and under conditions which stimulated cell activity. Further analysis of ion transport by cells exposed to radiation or adrenergic stimulation revealed a common increase in Na + /K + ATPase activity, and an increase in sodium influx across the plasma membrane. This sodium influx was found to be a critical step in the initiation of surfactant secretion. It is concluded that radiation exposure as well as other pulmonary toxicants can directly affect the membrane potential and ionic regulation of type II cells. Ion transport, particularly of sodium, plays an important role in the regulation of type II cell function

  4. Fluid Intelligence and Cognitive Reflection in a Strategic Environment: Evidence from Dominance-Solvable Games.

    Science.gov (United States)

    Hanaki, Nobuyuki; Jacquemet, Nicolas; Luchini, Stéphane; Zylbersztejn, Adam

    2016-01-01

    Dominance solvability is one of the most straightforward solution concepts in game theory. It is based on two principles: dominance (according to which players always use their dominant strategy) and iterated dominance (according to which players always act as if others apply the principle of dominance). However, existing experimental evidence questions the empirical accuracy of dominance solvability. In this study, we study the relationships between the key facets of dominance solvability and two cognitive skills, cognitive reflection, and fluid intelligence. We provide evidence that the behaviors in accordance with dominance and one-step iterated dominance are both predicted by one's fluid intelligence rather than cognitive reflection. Individual cognitive skills, however, only explain a small fraction of the observed failure of dominance solvability. The accuracy of theoretical predictions on strategic decision making thus not only depends on individual cognitive characteristics, but also, perhaps more importantly, on the decision making environment itself.

  5. Potential biosignatures in super-Earth atmospheres II. Photochemical responses.

    Science.gov (United States)

    Grenfell, J L; Gebauer, S; Godolt, M; Palczynski, K; Rauer, H; Stock, J; von Paris, P; Lehmann, R; Selsis, F

    2013-05-01

    Spectral characterization of super-Earth atmospheres for planets orbiting in the habitable zone of M dwarf stars is a key focus in exoplanet science. A central challenge is to understand and predict the expected spectral signals of atmospheric biosignatures (species associated with life). Our work applies a global-mean radiative-convective-photochemical column model assuming a planet with an Earth-like biomass and planetary development. We investigated planets with gravities of 1g and 3g and a surface pressure of 1 bar around central stars with spectral classes from M0 to M7. The spectral signals of the calculated planetary scenarios have been presented by in an earlier work by Rauer and colleagues. The main motivation of the present work is to perform a deeper analysis of the chemical processes in the planetary atmospheres. We apply a diagnostic tool, the Pathway Analysis Program, to shed light on the photochemical pathways that form and destroy biosignature species. Ozone is a potential biosignature for complex life. An important result of our analysis is a shift in the ozone photochemistry from mainly Chapman production (which dominates in Earth's stratosphere) to smog-dominated ozone production for planets in the habitable zone of cooler (M5-M7)-class dwarf stars. This result is associated with a lower energy flux in the UVB wavelength range from the central star, hence slower planetary atmospheric photolysis of molecular oxygen, which slows the Chapman ozone production. This is important for future atmospheric characterization missions because it provides an indication of different chemical environments that can lead to very different responses of ozone, for example, cosmic rays. Nitrous oxide, a biosignature for simple bacterial life, is favored for low stratospheric UV conditions, that is, on planets orbiting cooler stars. Transport of this species from its surface source to the stratosphere where it is destroyed can also be a key process. Comparing 1g with

  6. Solvability of Urysohn and Urysohn-Volterra equations with hysteresis in weighted spaces

    International Nuclear Information System (INIS)

    Darwish Mohamed Abdalla

    2005-09-01

    The existence of solutions to nonlinear integral equations of the second kind with hysteresis, of Urysohn-Volterra and Urysohn types has been established. We develop the solvability theory of Urysohn-Volterra equation with hysteresis in weighted spaces proposed by the author [M.A. Darwish, On solvability of Urysohn-Volterra equations with hysteresis in weighted spaces, J. Integral Equations and Application, 14(2) (2002), 151-163]. (author)

  7. On the labeling and symmetry adaptation of the solvable finite groups representations

    International Nuclear Information System (INIS)

    Caride, A.O.; Zanette, S.I.; Nogueira, S.R.A.

    1987-01-01

    We propose a method to simultaneously perform a symmetry adaptation and a labeling of the bases of the irreducible representations of the solvable finite groups. It is performed by difining a self-adjoint operator with ligenvalues which evidence the descent in symmetry of the group-subgroups sequences. We also prove two theorems on the canonicity of the cpomposition series of the solvable groups. (author) [pt

  8. Entanglement, decoherence and thermal relaxation in exactly solvable models

    International Nuclear Information System (INIS)

    Lychkovskiy, Oleg

    2011-01-01

    Exactly solvable models provide an opportunity to study different aspects of reduced quantum dynamics in detail. We consider the reduced dynamics of a single spin in finite XX and XY spin 1/2 chains. First we introduce a general expression describing the evolution of the reduced density matrix. This expression proves to be tractable when the combined closed system (i.e. open system plus environment) is integrable. Then we focus on comparing decoherence and thermalization timescales in the XX chain. We find that for a single spin these timescales are comparable, in contrast to what should be expected for a macroscopic body. This indicates that the process of quantum relaxation of a system with few accessible states can not be separated in two distinct stages - decoherence and thermalization. Finally, we turn to finite-size effects in the time evolution of a single spin in the XY chain. We observe three consecutive stages of the evolution: regular evolution, partial revivals, irregular (apparently chaotic) evolution. The duration of the regular stage is proportional to the number of spins in the chain. We observe a 'quiet and cold period' in the end of the regular stage, which breaks up abruptly at some threshold time.

  9. Another New Solvable Many-Body Model of Goldfish Type

    Directory of Open Access Journals (Sweden)

    Francesco Calogero

    2012-07-01

    Full Text Available A new solvable many-body problem is identified. It is characterized by nonlinear Newtonian equations of motion (''acceleration equal force'' featuring one-body and two-body velocity-dependent forces ''of goldfish type'' which determine the motion ofan arbitrary number $N$ of unit-mass point-particles in a plane. The $N$ (generally complex values $z_{n}(t$ at time $t$ ofthe $N$ coordinates of these moving particles are given by the $N$eigenvalues of a time-dependent $Nimes N$ matrix $U(t$explicitly known in terms of the $2N$ initial data $z_{n}(0$and $dot{z}_{n}(0 $. This model comes in two dif/ferentvariants, one featuring 3 arbitrary coupling constants, the other only 2; for special values of these parameters all solutions are completely periodic with the same period independent of the initial data (''isochrony''; for other special values of these parameters this property holds up to corrections vanishing exponentially as $tightarrow infty$ (''asymptotic isochrony''. Other isochronous variants of these models are also reported. Alternative formulations, obtained by changing the dependent variables from the $N$ zeros of a monic polynomial of degree $N$ to its $N$ coefficients, are also exhibited. Some mathematical findings implied by some of these results - such as Diophantine properties of the zeros of certain polynomials - are outlined, but their analysis is postponed to a separate paper.

  10. A Bethe ansatz solvable model for superpositions of Cooper pairs and condensed molecular bosons

    International Nuclear Information System (INIS)

    Hibberd, K.E.; Dunning, C.; Links, J.

    2006-01-01

    We introduce a general Hamiltonian describing coherent superpositions of Cooper pairs and condensed molecular bosons. For particular choices of the coupling parameters, the model is integrable. One integrable manifold, as well as the Bethe ansatz solution, was found by Dukelsky et al. [J. Dukelsky, G.G. Dussel, C. Esebbag, S. Pittel, Phys. Rev. Lett. 93 (2004) 050403]. Here we show that there is a second integrable manifold, established using the boundary quantum inverse scattering method. In this manner we obtain the exact solution by means of the algebraic Bethe ansatz. In the case where the Cooper pair energies are degenerate we examine the relationship between the spectrum of these integrable Hamiltonians and the quasi-exactly solvable spectrum of particular Schrodinger operators. For the solution we derive here the potential of the Schrodinger operator is given in terms of hyperbolic functions. For the solution derived by Dukelsky et al., loc. cit. the potential is sextic and the wavefunctions obey PT-symmetric boundary conditions. This latter case provides a novel example of an integrable Hermitian Hamiltonian acting on a Fock space whose states map into a Hilbert space of PT-symmetric wavefunctions defined on a contour in the complex plane

  11. Free Rhodium (II) citrate and rhodium (II) citrate magnetic carriers as potential strategies for breast cancer therapy

    Science.gov (United States)

    2011-01-01

    Background Rhodium (II) citrate (Rh2(H2cit)4) has significant antitumor, cytotoxic, and cytostatic activity on Ehrlich ascite tumor. Although toxic to normal cells, its lower toxicity when compared to carboxylate analogues of rhodium (II) indicates Rh2(H2cit)4 as a promising agent for chemotherapy. Nevertheless, few studies have been performed to explore this potential. Superparamagnetic particles of iron oxide (SPIOs) represent an attractive platform as carriers in drug delivery systems (DDS) because they can present greater specificity to tumor cells than normal cells. Thus, the association between Rh2(H2cit)4 and SPIOs can represent a strategy to enhance the former's therapeutic action. In this work, we report the cytotoxicity of free rhodium (II) citrate (Rh2(H2cit)4) and rhodium (II) citrate-loaded maghemite nanoparticles or magnetoliposomes, used as drug delivery systems, on both normal and carcinoma breast cell cultures. Results Treatment with free Rh2(H2cit)4 induced cytotoxicity that was dependent on dose, time, and cell line. The IC50 values showed that this effect was more intense on breast normal cells (MCF-10A) than on breast carcinoma cells (MCF-7 and 4T1). However, the treatment with 50 μM Rh2(H2cit)4-loaded maghemite nanoparticles (Magh-Rh2(H2cit)4) and Rh2(H2cit)4-loaded magnetoliposomes (Lip-Magh-Rh2(H2cit)4) induced a higher cytotoxicity on MCF-7 and 4T1 than on MCF-10A (p rhodium (II) citrate-loaded maghemite nanoparticles and magnetoliposomes induced more specific cytotoxicity on breast carcinoma cells than on breast normal cells, which is the opposite of the results observed with free Rh2(H2cit)4 treatment. Thus, magnetic nanoparticles represent an attractive platform as carriers in Rh2(H2cit)4 delivery systems, since they can act preferentially in tumor cells. Therefore, these nanopaticulate systems may be explored as a potential tool for chemotherapy drug development. PMID:21443799

  12. Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity

    Directory of Open Access Journals (Sweden)

    Mostafa Wanees Ahmed El husseny

    2017-01-01

    Full Text Available Adipokines are bioactive molecules that regulate several physiological functions such as energy balance, insulin sensitization, appetite regulation, inflammatory response, and vascular homeostasis. They include proinflammatory cytokines such as adipocyte fatty acid binding protein (A-FABP and anti-inflammatory cytokines such as adiponectin, as well as vasodilator and vasoconstrictor molecules. In obesity and type II diabetes mellitus (DM, insulin resistance causes impairment of the endocrine function of the perivascular adipose tissue, an imbalance in the secretion of vasoconstrictor and vasodilator molecules, and an increased production of reactive oxygen species. Recent studies have shown that targeting plasma levels of adipokines or the expression of their receptors can increase insulin sensitivity, improve vascular function, and reduce the risk of cardiovascular morbidity and mortality. Several reviews have discussed the potential of adipokines as therapeutic targets for type II DM and obesity; however, this review is the first to focus on their therapeutic potential for vascular dysfunction in type II DM and obesity.

  13. Angiotensin II potentiates adrenergic and muscarinic modulation of guinea pig intracardiac neurons.

    Science.gov (United States)

    Girasole, Allison E; Palmer, Christopher P; Corrado, Samantha L; Marie Southerland, E; Ardell, Jeffrey L; Hardwick, Jean C

    2011-11-01

    The intrinsic cardiac plexus represents a major peripheral integration site for neuronal, hormonal, and locally produced neuromodulators controlling efferent neuronal output to the heart. This study examined the interdependence of norepinephrine, muscarinic agonists, and ANG II, to modulate intrinsic cardiac neuronal activity. Intracellular voltage recordings from whole-mount preparations of the guinea pig cardiac plexus were used to determine changes in active and passive electrical properties of individual intrinsic cardiac neurons. Application of either adrenergic or muscarinic agonists induced changes in neuronal resting membrane potentials, decreased afterhyperpolarization duration of single action potentials, and increased neuronal excitability. Adrenergic responses were inhibited by removal of extracellular calcium ions, while muscarinic responses were inhibited by application of TEA. The adrenergic responses were heterogeneous, responding to a variety of receptor-specific agonists (phenylephrine, clonidine, dobutamine, and terbutaline), although α-receptor agonists produced the most frequent responses. Application of ANG II alone produced a significant increase in excitability, while application of ANG II in combination with either adrenergic or muscarinic agonists produced a much larger potentiation of excitability. The ANG II-induced modulation of firing was blocked by the angiotensin type 2 (AT(2)) receptor inhibitor PD 123319 and was mimicked by the AT(2) receptor agonist CGP-42112A. AT(1) receptor blockade with telmasartin did not alter neuronal responses to ANG II. These data demonstrate that ANG II potentiates both muscarinically and adrenergically mediated activation of intrinsic cardiac neurons, doing so primarily via AT(2) receptor-dependent mechanisms. These neurohumoral interactions may be fundamental to regulation of neuronal excitability within the intrinsic cardiac nervous system.

  14. Complexation Effect on Redox Potential of Iron(III)-Iron(II) Couple: A Simple Potentiometric Experiment

    Science.gov (United States)

    Rizvi, Masood Ahmad; Syed, Raashid Maqsood; Khan, Badruddin

    2011-01-01

    A titration curve with multiple inflection points results when a mixture of two or more reducing agents with sufficiently different reduction potentials are titrated. In this experiment iron(II) complexes are combined into a mixture of reducing agents and are oxidized to the corresponding iron(III) complexes. As all of the complexes involve the…

  15. Orbital correlation effects. II. Potential curve and ionization potential of boron hydride

    International Nuclear Information System (INIS)

    Mehler, E.L.; Van der Vele, G.A.; Nieuwpoort, W.C.

    1975-01-01

    With the help of the independent pair-potential approximation (IPPA) the valence-shell correlation effects in BH have been calculated at nine internuclear separations. The results are compared with several other methods, including the coupled electron pair approximation (CEPA) and a full configuration interaction expansion. The stability of the IPPA against a unitary transformation of the occupied orbitals has also been investigated, and it is shown that the IPPA is nearly invariant against such transformations. The Dunham procedure has been applied to the results, and the spectroscopic constants obtained from the various approximations are compared. It is furthermore demonstrated that many of the defects present in the Hartree--Fock part of the potential curve and arising from the use of medium-quality basis sets can be eliminated by combining the correlation results with Hartree--Fock results from good-quality basis sets and reapplying the Dunham procedure. Finally the IPPA has been applied to BH + , and the first vertical ionization potential of BH was determined

  16. Calcium/calmodulin-dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes.

    Science.gov (United States)

    Li, Yuwei; Ahrens, Molly J; Wu, Amy; Liu, Jennifer; Dudley, Andrew T

    2011-01-01

    For tissues that develop throughout embryogenesis and into postnatal life, the generation of differentiated cells to promote tissue growth is at odds with the requirement to maintain the stem cell/progenitor cell population to preserve future growth potential. In the growth plate cartilage, this balance is achieved in part by establishing a proliferative phase that amplifies the number of progenitor cells prior to terminal differentiation into hypertrophic chondrocytes. Here, we show that endogenous calcium/calmodulin-dependent protein kinase II (CamkII, also known as Camk2) activity is upregulated prior to hypertrophy and that loss of CamkII function substantially blocks the transition from proliferation to hypertrophy. Wnt signaling and Pthrp-induced phosphatase activity negatively regulate CamkII activity. Release of this repression results in activation of multiple effector pathways, including Runx2- and β-catenin-dependent pathways. We present an integrated model for the regulation of proliferation potential by CamkII activity that has important implications for studies of growth control and adult progenitor/stem cell populations.

  17. Calculation of the magnetic vector potential in the TJ-II

    International Nuclear Information System (INIS)

    Lopez Fraguas, A.; Lopez Bruna, D.; Romero, J. A.

    2005-01-01

    The properties of the vector magnetic potential and its usefulness to calculate magnetic fluxes in both stationary and time-dependent conditions are p revised in this report. We have adapted to the TJ-II Flexible Heliac efficient numerical expressions to calculate the vector potential, calculating in addition the magnetic flux with this formalism in circumstances whose complexity makes very convenient the use of the vector potential. The result on induced voltages offer theoretical support to the measurements of induced voltage due to the OH coils in the plasma, like the measurements provided by the loop voltage diagnostic installed in the TJ-II, as well as to the cylindrical approximation of the plasma often used to interpret experimental data. (Author) 11 refs

  18. A large class of solvable multistate Landau–Zener models and quantum integrability

    Science.gov (United States)

    Chernyak, Vladimir Y.; Sinitsyn, Nikolai A.; Sun, Chen

    2018-06-01

    The concept of quantum integrability has been introduced recently for quantum systems with explicitly time-dependent Hamiltonians (Sinitsyn et al 2018 Phys. Rev. Lett. 120 190402). Within the multistate Landau–Zener (MLZ) theory, however, there has been a successful alternative approach to identify and solve complex time-dependent models (Sinitsyn and Chernyak 2017 J. Phys. A: Math. Theor. 50 255203). Here we compare both methods by applying them to a new class of exactly solvable MLZ models. This class contains systems with an arbitrary number of interacting states and shows quick growth with N number of exact adiabatic energy crossing points, which appear at different moments of time. At each N, transition probabilities in these systems can be found analytically and exactly but complexity and variety of solutions in this class also grow with N quickly. We illustrate how common features of solvable MLZ systems appear from quantum integrability and develop an approach to further classification of solvable MLZ problems.

  19. Copper (II) and zinc (II) complexes with flavanone derivatives: Identification of potential cholinesterase inhibitors by on-flow assays.

    Science.gov (United States)

    Sarria, André Lucio Franceschini; Vilela, Adriana Ferreira Lopes; Frugeri, Bárbara Mammana; Fernandes, João Batista; Carlos, Rose Maria; da Silva, Maria Fátima das Graças Fernandes; Cass, Quezia Bezerra; Cardoso, Carmen Lúcia

    2016-11-01

    Metal chelates strongly influence the nature and magnitude of pharmacological activities in flavonoids. In recent years, studies have shown that a promising class of flavanone-metal ion complexes can act as selective cholinesterase inhibitors (ChEIs), which has led our group to synthesize a new series of flavanone derivatives (hesperidin, hesperetin, naringin, and naringenin) complexed to either copper (II) or zinc (II) and to evaluate their potential use as selective ChEIs. Most of the synthesized complexes exhibited greater inhibitory activity against acetylcholinesterase (AChE) than against butyrylcholinesterase (BChE). Nine of these complexes constituted potent, reversible, and selective ChEIs with inhibitory potency (IC 50 ) and inhibitory constant (K i ) ranging from 0.02 to 4.5μM. Copper complexes with flavanone-bipyridine derivatives afforded the best inhibitory activity against AChE and BChE. The complex Cu(naringin)(2,2'-bipyridine) (11) gave IC 50 and K i values of 0.012±0.002 and 0.07±0.01μM for huAChE, respectively, which were lower than the inhibitory values obtained for standard galanthamine (IC 50 =206±30.0 and K i =126±18.0μM). Evaluation of the inhibitory activity of this complex against butyrylcholinesterase from human serum (huBChE) gave IC 50 and K i values of 8.0±1.4 and 2.0±0.1μM, respectively. A Liquid Chromatography-Immobilized Capillary Enzyme Reactor by UV detection (LC-ICER-UV) assay allowed us to determine the IC 50 and K i values and the type of mechanism for the best inhibitors. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. New quasi-exactly solvable Hermitian as well as non-Hermitian PT ...

    Indian Academy of Sciences (India)

    Abstract. We start with quasi-exactly solvable (QES) Hermitian (and hence real) as ... the time reversal transformation t → −t and further, one replaces i → −i. One can ..... F M Fernandez, R Guardiola, J Ros and M Znojil, J. Phys. A32, 3105 ...

  1. Hierarchy of exactly solvable spin-1/2 chains with so (N)_I critical points

    NARCIS (Netherlands)

    Lahtinen, V.; Mansson, T.; Ardonne, E.

    2014-01-01

    We construct a hierarchy of exactly solvable spin-1/2 chains with so(N)1 critical points. Our construction is based on the framework of condensate-induced transitions between topological phases. We employ this framework to construct a Hamiltonian term that couples N transverse field Ising chains

  2. Interaction of attosecond electromagnetic pulses with atoms: The exactly solvable model

    International Nuclear Information System (INIS)

    Popov, Yu. V.; Kouzakov, K. A.; Vinitsky, S. I.; Gusev, A. A.

    2007-01-01

    We consider the exactly solvable model of interaction of zero-duration electromagnetic pulses with an atom. The model has a number of peculiar properties which are outlined in the cases of a single pulse and two opposite pulses. In perspective, it can be useful in different fields of physics involving interaction of attosecond laser pulses with quantum systems

  3. Flatland Position-Dependent-Mass: Polar Coordinates, Separability and Exact Solvability

    Directory of Open Access Journals (Sweden)

    Omar Mustafa

    2010-10-01

    Full Text Available The kinetic energy operator with position-dependent-mass in plane polar coordinates is obtained. The separability of the corresponding Schrödinger equation is discussed. A hypothetical toy model is reported and two exactly solvable examples are studied.

  4. Exactly solvable model of phase transition between hadron and quark-gluon-matter

    International Nuclear Information System (INIS)

    Gorenstein, M.I.; Petrov, V.K.; Shelest, V.P.; Zinovjev, G.M.

    1982-01-01

    An exactly solvable model of phase transition between hadron and quark-gluon matter is proposed. The hadron phase of this model is considered as a gas of bags filled by point massless constituents. The mass and volume spectrum of the bag is found. The thermodynamical characteristics of a bag gas in the neighbourhood of a phase transition point are ascertained in analytical form

  5. Constructing solvable groups with derived length four and four character degrees

    OpenAIRE

    Lewis, Mark L.

    2018-01-01

    In this paper, we present a new method to construct solvable groups with derived length four and four character degrees. We then use this method to present a number of new families of groups with derived length four and four character degrees.

  6. On the efficient solvability of a simple class of nonlinear knapsack ...

    African Journals Online (AJOL)

    Abstract. In this paper the efficient solvability of a class of nonlinear knapsack problems are investigated by means of the problem's necessary and sufficient conditions. It is shown that, from the general theory, it is impossible to determine sufficient conditions for a solution to be globally optimal. Furthermore, it is shown that ...

  7. Production of a sterile species via active-sterile mixing: An exactly solvable model

    Science.gov (United States)

    Boyanovsky, D.

    2007-11-01

    The production of a sterile species via active-sterile mixing in a thermal medium is studied in an exactly solvable model. The exact time evolution of the sterile distribution function is determined by the dispersion relations and damping rates Γ1,2 for the quasiparticle modes. These depend on γ˜=Γaa/2ΔE, with Γaa the interaction rate of the active species in absence of mixing and ΔE the oscillation frequency in the medium without damping. γ˜≪1, γ˜≫1 describe the weak and strong damping limits, respectively. For γ˜≪1, Γ1=Γaacos⁡2θm; Γ2=Γaasin⁡2θm where θm is the mixing angle in the medium and the sterile distribution function does not obey a simple rate equation. For γ˜≫1, Γ1=Γaa and Γ2=Γaasin⁡22θm/4γ˜2, is the sterile production rate. In this regime sterile production is suppressed and the oscillation frequency vanishes at an Mikheyev-Smirnov-Wolfenstein (MSW) resonance, with a breakdown of adiabaticity. These are consequences of quantum Zeno suppression. For active neutrinos with standard model interactions the strong damping limit is only available near an MSW resonance if sin⁡2θ≪αw with θ the vacuum mixing angle. The full set of quantum kinetic equations for sterile production for arbitrary γ˜ are obtained from the quantum master equation. Cosmological resonant sterile neutrino production is quantum Zeno suppressed relieving potential uncertainties associated with the QCD phase transition.

  8. Probing Fe (III)/Fe (II) redox potential in a clayey material

    International Nuclear Information System (INIS)

    Tournassat, Christophe; Chainet, Fabien; Betelu, Stephanie; Hadi, Jebril; Gaucher, Eric C.; Ignatiadis, Ioannis; Greneche, Jean-Marc; Charlet, Laurent

    2010-01-01

    Document available in extended abstract form only. Redox is one of the main factors affecting the migration of redox-sensitive radionuclides. As a consequence reducing conditions are considered of strategic importance for the confinement properties of a clayey formation towards nuclear waste. A representative redox potential of clay formation such as Callovian- Oxfordian (COx) can be derived from thermodynamic calculations considering equilibrium between observed redox phases such as pyrite and siderite. However, there is little information on the reactivity of the different reservoirs of redox constituents in this type of complex material. The present study aims at investigating the reactivity of the Fe(III)/Fe(II) redox couple in the structure of clay minerals using different investigation methods: electrochemistry and O 2 reduction kinetic experiments. Clay modified electrodes were specifically designed to probe Fe(III)/Fe(II) redox potential in the structure of clay minerals. The clay fraction of a Callovian-Oxfordian argillite sample originating from the same level than ANDRA underground research laboratory was used after pre-treatment to remove organic matter and accessory minerals such as pyrite that could influence redox potential measurements. These electrodes were used to verify the validity of the model of Favre et al. (2006) that links the redox potential (E clay ) to the the Fe(II)/Fe tot ratio in the structure (m rel ), the pH and the sodium concentration in solution: equation 1. The good agreement between direct potential measurements and model prediction provides a strong evidence of the relevance of this model in our experimental conditions although the clay composition and its too low Fe content do not a priori fulfil the conditions set by Drits and Manceau (2000) for the calculation of K 0 parameter. Following the verification of the model, we tried to apply it to the specific case of a Callovian-Oxfordian sample that had been very well preserved

  9. Synthesis, structural characterization, and pro-apoptotic activity of 1-indanone thiosemicarbazone platinum(II) and palladium(II) complexes: potential as antileukemic agents.

    Science.gov (United States)

    Gómez, Natalia; Santos, Diego; Vázquez, Ramiro; Suescun, Leopoldo; Mombrú, Alvaro; Vermeulen, Monica; Finkielsztein, Liliana; Shayo, Carina; Moglioni, Albertina; Gambino, Dinorah; Davio, Carlos

    2011-08-01

    In the search for alternative chemotherapeutic strategies against leukemia, various 1-indanone thiosemicarbazones, as well as eight novel platinum(II) and palladium(II) complexes, with the formula [MCl₂(HL)] and [M(HL)(L)]Cl, derived from two 1-indanone thiosemicarbazones were synthesized and tested for antiproliferative activity against the human leukemia U937 cell line. The crystal structure of [Pt(HL1)(L1)]Cl·2MeOH, where L1=1-indanone thiosemicarbazone, was solved by X-ray diffraction. Free thiosemicarbazone ligands showed no antiproliferative effect, but the corresponding platinum(II) and palladium(II) complexes inhibited cell proliferation and induced apoptosis. Platinum(II) complexes also displayed selective apoptotic activity in U937 cells but not in peripheral blood monocytes or the human hepatocellular carcinoma HepG2 cell line used to screen for potential hepatotoxicity. Present findings show that, in U937 cells, 1-indanone thiosemicarbazones coordinated to palladium(II) were more cytotoxic than those complexed with platinum(II), although the latter were found to be more selective for leukemic cells suggesting that they are promising compounds with potential therapeutic application against hematological malignancies. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Unitary-matrix models as exactly solvable string theories

    Science.gov (United States)

    Periwal, Vipul; Shevitz, Danny

    1990-01-01

    Exact differential equations are presently found for the scaling functions of models of unitary matrices which are solved in a double-scaling limit, using orthogonal polynomials on a circle. For the case of the simplest, k = 1 model, the Painleve II equation with constant 0 is obtained; possible nonperturbative phase transitions exist for these models. Equations are presented for k = 2 and 3, and discussed with a view to asymptotic behavior.

  11. Exact analytic solutions generated from stipulated Morse and trigonometric Scarf potentials

    International Nuclear Information System (INIS)

    Saikia, N; Ahmed, S A S

    2011-01-01

    The extended transformation method has been applied to the exactly solvable stipulated Morse potential and trigonometric Scarf potential, to generate a set of exactly solvable quantum systems (QSs) in any chosen dimension. Bound state solutions of the exactly solvable potentials are given. The generated QSs are generally of Sturmian form. We also report a system case-specific regrouping technique to convert a Sturmian QS to a normal QS. A second-order application of the transformation method is given. The normalizability of the generated QSs is generally given in Sturmian form.

  12. Investigating solvability and complexity of linear active networks by means of matroids

    DEFF Research Database (Denmark)

    Petersen, Bjørn

    1979-01-01

    The solvability and complexity problems of finear active network are approached from a purely combinatorial point of view, using the concepts of matroid theory. Since the method is purely combinatorial, we take into account the network topology alone. Under this assumption necessary and sufficient...... conditions are given for the unique solvablity of linear active networks. The complexity and the number of dc-eigenfrequencies are also given. The method enables.you to decide if degeneracies are due to the topology alone, or if they are caused by special relations among network parameter values....... If the network parameter values are taken into account, the complexity and number of dc-eigenfrequencies given by the method, are only upper and lower bounds, respectively. The above conditions are fairly easily checked, and the complexity and number of dc-elgenfrequencies are found, using polynomially bounded...

  13. Topological Galois theory solvability and unsolvability of equations in finite terms

    CERN Document Server

    Khovanskii, Askold

    2014-01-01

    This book provides a detailed and largely self-contained description of various classical and new results on solvability and unsolvability of equations in explicit form. In particular, it offers a complete exposition of the relatively new area of topological Galois theory, initiated by the author. Applications of Galois theory to solvability of algebraic equations by radicals, basics of Picard–Vessiot theory, and Liouville's results on the class of functions representable by quadratures are also discussed. A unique feature of this book is that recent results are presented in the same elementary manner as classical Galois theory, which will make the book useful and interesting to readers with varied backgrounds in mathematics, from undergraduate students to researchers. In this English-language edition, extra material has been added (Appendices A–D), the last two of which were written jointly with Yura Burda.

  14. Hydrodynamics at the smallest scales: a solvability criterion for Navier-Stokes equations in high dimensions.

    Science.gov (United States)

    Viswanathan, T M; Viswanathan, G M

    2011-01-28

    Strong global solvability is difficult to prove for high-dimensional hydrodynamic systems because of the complex interplay between nonlinearity and scale invariance. We define the Ladyzhenskaya-Lions exponent α(L)(n)=(2+n)/4 for Navier-Stokes equations with dissipation -(-Δ)(α) in R(n), for all n≥2. We review the proof of strong global solvability when α≥α(L)(n), given smooth initial data. If the corresponding Euler equations for n>2 were to allow uncontrolled growth of the enstrophy (1/2)∥∇u∥(L²)(2), then no globally controlled coercive quantity is currently known to exist that can regularize solutions of the Navier-Stokes equations for α<α(L)(n). The energy is critical under scale transformations only for α=α(L)(n).

  15. Deuteron form factors and e-d polarization observables for the Paris and Graz-II potentials

    International Nuclear Information System (INIS)

    Schwarz, K.; Plessas, W.; Mathelitsch, L.

    1983-01-01

    Elastic e-d scattering is studied employing the meson-theoretical Paris potential and the non-local separable Graz-II potential. Electric and magnetic form factors are calculated with inclusion of meson-exchange currents and compared to existing experimental data. Deuteron vector and tensor polarizations are predicted and discussed in relation to the deuteron wave functions of the potential models considered. Thereby the off-shell behaviour of the Graz-II interaction is found to be close to that one of the Paris potential over the most important domain of low and moderate off-shell moments. (Author)

  16. Three-level models solvable in terms of the Clausen function

    Energy Technology Data Exchange (ETDEWEB)

    Ishkhanyan, Artur [Engineering Center of Armenian National Academy of Sciences, Ashtarak-2, 378410 (Armenia); Suominen, Kalle-Antti [Helsinki Institute of Physics, PL 64, FIN-00014 Helsingin yliopisto (Finland)

    2003-07-04

    The problem of analytical integrability of the three-level problem by reduction of the time-dependent Schroedinger equations to the third-order linear differential equation satisfied by the generalized hypergeometric functions {sub 3}F{sub 2} is considered. A total of 12 infinite classes of models solvable in terms of these functions is found, most of which are new and others are generalizations of the previously known families.

  17. Some exactly solvable models in quantum mechanics and the low energy expansions

    International Nuclear Information System (INIS)

    Albeverio, S.; Hoeegh-Krohn, R.; Holden, H.; Gesztesy, F.

    We give an overview of recent results on exactly solvable models in quantum mechanics. In particular we discuss point interactions located at finitely or infinitely many centers, in one and three dimensions. Results about the resolvent, energy eigenvalues and resonances, scattering quantitites as well as eigenfunctions and corresponding low energy expansions are mentioned, with particular attention to the case of three-dimensional crystals. (orig.)

  18. Solvability in the sense of sequences to some non-Fredholm operators

    Directory of Open Access Journals (Sweden)

    Vitaly Volpert

    2013-07-01

    Full Text Available We study the solvability of certain linear nonhomogeneous elliptic problems and show that under reasonable technical conditions the convergence in $L^2(mathbb{R}^d$ of their right sides implies the existence and the convergence in $H^2(mathbb{R}^d$ of the solutions. The equations involve second order differential operators without Fredholm property and we use the methods of spectral and scattering theory for Schrodinger type operators analogously to our preceding work [17].

  19. Three-level models solvable in terms of the Clausen function

    International Nuclear Information System (INIS)

    Ishkhanyan, Artur; Suominen, Kalle-Antti

    2003-01-01

    The problem of analytical integrability of the three-level problem by reduction of the time-dependent Schroedinger equations to the third-order linear differential equation satisfied by the generalized hypergeometric functions 3 F 2 is considered. A total of 12 infinite classes of models solvable in terms of these functions is found, most of which are new and others are generalizations of the previously known families

  20. Global solvability of the differential operators non-invariants on semi-simple Lie groups

    International Nuclear Information System (INIS)

    El Hussein, K.

    1991-09-01

    Let G be a connected semi-simple Lie group with finite centre and let G=KAN be the Iwasawa decomposition of G. Let P be a differential operator on G, which is right invariant by the sub-group AN and left invariant by the sub-group K. In this paper, we give a necessary and sufficient condition for the global solvability of P on G. (author). 5 refs

  1. Striking hematological abnormalities in patients with microcephalic osteodysplastic primordial dwarfism type II (MOPD II): a potential role of pericentrin in hematopoiesis.

    Science.gov (United States)

    Unal, Sule; Alanay, Yasemin; Cetin, Mualla; Boduroglu, Koray; Utine, Eda; Cormier-Daire, Valerie; Huber, Celine; Ozsurekci, Yasemin; Kilic, Esra; Simsek Kiper, Ozlem Pelin; Gumruk, Fatma

    2014-02-01

    Microcephalic osteodysplastic primordial dwarfism type II (MOPD II) is a rare primordial dwarfism that is similar to Seckel syndrome. Seckel syndrome is known to be associated with various hematological abnormalities; however, hematological findings in MOPD II patients have not been previously reported. The present study aimed to describe the hematological findings in a series of eight patients with MOPD II from a single center. The study included eight patients with MOPD II that were analyzed via molecular testing, and physical and laboratory examinations. Molecular testing showed that seven of the eight patients had pericentrin (PCNT) gene mutations. Hematological evaluation showed that 7 (87.5%) patients had thrombocytosis, 6 (75%) had leukocytosis, 5 (62.5%) had both leukocytosis and thrombocytosis, and 2 (25%) had anemia. We report leukocytosis and thrombocytosis as a common hematologic abnormality in patients with MOPD II. The present findings may improve our understanding of the potential function of the PCNT gene in hematopoietic cell proliferation and differentiation. © 2013 Wiley Periodicals, Inc.

  2. Statistical mechanics and dynamics of solvable models with long-range interactions

    International Nuclear Information System (INIS)

    Campa, Alessandro; Dauxois, Thierry; Ruffo, Stefano

    2009-01-01

    For systems with long-range interactions, the two-body potential decays at large distances as V(r)∼1/r α , with α≤d, where d is the space dimension. Examples are: gravitational systems, two-dimensional hydrodynamics, two-dimensional elasticity, charged and dipolar systems. Although such systems can be made extensive, they are intrinsically non additive: the sum of the energies of macroscopic subsystems is not equal to the energy of the whole system. Moreover, the space of accessible macroscopic thermodynamic parameters might be non convex. The violation of these two basic properties of the thermodynamics of short-range systems is at the origin of ensemble inequivalence. In turn, this inequivalence implies that specific heat can be negative in the microcanonical ensemble, and temperature jumps can appear at microcanonical first order phase transitions. The lack of convexity allows us to easily spot regions of parameter space where ergodicity may be broken. Historically, negative specific heat had been found for gravitational systems and was thought to be a specific property of a system for which the existence of standard equilibrium statistical mechanics itself was doubted. Realizing that such properties may be present for a wider class of systems has renewed the interest in long-range interactions. Here, we present a comprehensive review of the recent advances on the statistical mechanics and out-of-equilibrium dynamics of solvable systems with long-range interactions. The core of the review consists in the detailed presentation of the concept of ensemble inequivalence, as exemplified by the exact solution, in the microcanonical and canonical ensembles, of mean-field type models. Remarkably, the entropy of all these models can be obtained using the method of large deviations. Long-range interacting systems display an extremely slow relaxation towards thermodynamic equilibrium and, what is more striking, the convergence towards quasi-stationary states. The

  3. Calculation of the magnetic vector potential in the TJ-II; Calculo del Potencial Magnetico Vector en el TJ-II

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Fraguas, A.; Lopez Bruna, D.; Romero, J. A.

    2005-07-01

    The properties of the vector magnetic potential and its usefulness to calculate magnetic fluxes in both stationary and time-dependent conditions are p revised in this report. We have adapted to the TJ-II Flexible Heliac efficient numerical expressions to calculate the vector potential, calculating in addition the magnetic flux with this formalism in circumstances whose complexity makes very convenient the use of the vector potential. The result on induced voltages offer theoretical support to the measurements of induced voltage due to the OH coils in the plasma, like the measurements provided by the loop voltage diagnostic installed in the TJ-II, as well as to the cylindrical approximation of the plasma often used to interpret experimental data. (Author) 11 refs.

  4. Fractional distillation as a strategy for reducing the genotoxic potential of SRC-II coal liquids: a status report

    Energy Technology Data Exchange (ETDEWEB)

    Pelroy, R.A.; Wilson, B.W.

    1981-09-01

    This report presents results of studies on the effects of fractional distillation on the genotoxic potential of Solvent Refined Coal (SRC-II) liquids. SRC-II source materials and distilled liquids were provided by Pittsburg and Midway Coal Mining Co. Fractional distillations were conducted on products from the P-99 process development unit operating under conditions approximating those anticipated at the SRC-II demonstration facility. Distillation cuts were subjected to chemical fractionation, in vitro bioassay and initial chemical analysis. Findings are discussed as they relate to the temperature at which various distillate cuts were produced. This document is the first of two status reports scheduled for 1981 describing these studies.

  5. Symmetrized quartic polynomial oscillators and their partial exact solvability

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2016-01-01

    Roč. 380, č. 16 (2016), s. 1414-1418 ISSN 0375-9601 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : Quantum bound states * Non-numerical methods * Piecewise analytic potentials * Quartic oscillators * Quasi-extact states Subject RIV: BE - Theoretical Physics Impact factor: 1.772, year: 2016

  6. Quasi-exactly solvable models in quantum mechanics

    International Nuclear Information System (INIS)

    Montemayor, R.; Salem, L.D.

    1990-01-01

    An extension of the application range of a method that studies partial resolution in quantum mechanics and that is based on the Ricatti equation, is carried out through adequately defined mappings. As an example of the use of these mappings, new families of Morse and Poeschl-Teller potentials are identified. A detailed discussion is made of their characteristics and the solutions obtained. (Author). 3 refs

  7. On some solvable models in non-relativistic quantum mechanics

    International Nuclear Information System (INIS)

    Shabani, J.; Shayo, L.K.

    1985-11-01

    The theory of self-adjoint extensions is employed to generalize some previous results in non-relativistic quantum interactions. In particular, the Hamiltonian H=-Δ+V, where Δ is the Laplacian and the potential V consists of a strongly singular interaction, a Coulomb and a delta-shell interaction is studied. The spectral properties are discussed and phase shifts as well as low energy parameters are obtained. (author)

  8. The Potential Economic Impact of Electricity Restructuring in the State of Oklahoma: Phase II Report; FINAL

    International Nuclear Information System (INIS)

    Hadley, SW

    2001-01-01

    Because of the recent experiences of several states undergoing restructuring (e.g., higher prices, greater volatility, lower reliability), concerns have been raised in states currently considering restructuring as to whether their systems are equally vulnerable. Factors such as local generation costs, transmission constraints, market concentration, and market design can all play a role in the success or failure of the market. These factors along with the mix of generation capacity supplying the state will influence the relative prices paid by consumers. The purpose of this project is to provide a model and process to evaluate the potential price and economic impacts of restructuring the Oklahoma electric industry. The Phase I report concentrated on providing an analysis of the Oklahoma system in the near-term, using only present generation resources and customer demands. This Phase II study analyzed the Oklahoma power market in 2010, incorporating the potential of new generation resources and customer responses. Five key findings of this Phase II were made: (1) Projected expansion in generating capacity exceeds by over 3,000 MW the demands within the state plus the amount that could be exported with the current transmission system. (2) Even with reduced new plant construction, most new plants could lose money (although residential consumers would see lower rates) unless they have sufficient market power to raise their prices without losing significant market share (Figure S-1). (3) If new plants can raise prices to stay profitable, existing low-cost coal and hydro plants will have very high profits. Average prices to customers could be 5% to 25% higher than regulated rates (Figure S-1). If the coal and hydro plants are priced at cost-based rates (through long-term contracts or continued regulation) while all other plants use market-based rates then prices are lower. (4) Customer response to real-time prices can lower the peak capacity requirements by around 9

  9. Action potentials and ion conductances in wild-type and CALHM1-knockout type II taste cells

    Science.gov (United States)

    Saung, Wint Thu; Foskett, J. Kevin

    2017-01-01

    Taste bud type II cells fire action potentials in response to tastants, triggering nonvesicular ATP release to gustatory neurons via voltage-gated CALHM1-associated ion channels. Whereas CALHM1 regulates mouse cortical neuron excitability, its roles in regulating type II cell excitability are unknown. In this study, we compared membrane conductances and action potentials in single identified TRPM5-GFP-expressing circumvallate papillae type II cells acutely isolated from wild-type (WT) and Calhm1 knockout (KO) mice. The activation kinetics of large voltage-gated outward currents were accelerated in cells from Calhm1 KO mice, and their associated nonselective tail currents, previously shown to be highly correlated with ATP release, were completely absent in Calhm1 KO cells, suggesting that CALHM1 contributes to all of these currents. Calhm1 deletion did not significantly alter resting membrane potential or input resistance, the amplitudes and kinetics of Na+ currents either estimated from action potentials or recorded from steady-state voltage pulses, or action potential threshold, overshoot peak, afterhyperpolarization, and firing frequency. However, Calhm1 deletion reduced the half-widths of action potentials and accelerated the deactivation kinetics of transient outward currents, suggesting that the CALHM1-associated conductance becomes activated during the repolarization phase of action potentials. NEW & NOTEWORTHY CALHM1 is an essential ion channel component of the ATP neurotransmitter release mechanism in type II taste bud cells. Its contribution to type II cell resting membrane properties and excitability is unknown. Nonselective voltage-gated currents, previously associated with ATP release, were absent in cells lacking CALHM1. Calhm1 deletion was without effects on resting membrane properties or voltage-gated Na+ and K+ channels but contributed modestly to the kinetics of action potentials. PMID:28202574

  10. Solvable Model of a Generic Trapped Mixture of Interacting Bosons: Many-Body and Mean-Field Properties

    Science.gov (United States)

    Klaiman, S.; Streltsov, A. I.; Alon, O. E.

    2018-04-01

    A solvable model of a generic trapped bosonic mixture, N 1 bosons of mass m 1 and N 2 bosons of mass m 2 trapped in an harmonic potential of frequency ω and interacting by harmonic inter-particle interactions of strengths λ 1, λ 2, and λ 12, is discussed. It has recently been shown for the ground state [J. Phys. A 50, 295002 (2017)] that in the infinite-particle limit, when the interaction parameters λ 1(N 1 ‑ 1), λ 2(N 2 ‑ 1), λ 12 N 1, λ 12 N 2 are held fixed, each of the species is 100% condensed and its density per particle as well as the total energy per particle are given by the solution of the coupled Gross-Pitaevskii equations of the mixture. In the present work we investigate properties of the trapped generic mixture at the infinite-particle limit, and find differences between the many-body and mean-field descriptions of the mixture, despite each species being 100%. We compute analytically and analyze, both for the mixture and for each species, the center-of-mass position and momentum variances, their uncertainty product, the angular-momentum variance, as well as the overlap of the exact and Gross-Pitaevskii wavefunctions of the mixture. The results obtained in this work can be considered as a step forward in characterizing how important are many-body effects in a fully condensed trapped bosonic mixture at the infinite-particle limit.

  11. Jacobi algebra and potentials generated by it

    International Nuclear Information System (INIS)

    Lutsenko, I.M.

    1993-01-01

    It is shown that the Jacobi algebra QJ(3) generates potentials that admit exact solution in relativistic and nonrelativistic quantum mechanics. Being a spectrum-generating dynamic symmetry algebra and possessing the ladder property, QJ(3) makes it possible to find the wave functions in the coordinate representation. The exactly solvable potentials specified in explicit form are regarded as a special case of a larger class of exactly solvable potentials specified implicitly. The connection between classical and quantum problems possessing exact solutions is obtained by means of QJ(3). 13 refs

  12. Hydramite II screening tests of potential bremsstrahlung converter debris shield materials

    International Nuclear Information System (INIS)

    Reedy, E.D. Jr.; Hedemann, M.A.; Stark, M.A.

    1986-03-01

    Results of a brief test series aimed at screening a number of potential bremsstrahlung converter debris shield materials are reported. These tests were run on Sandia National Laboratories' Hydramite II accelerator using a diode configuration which produces a pinched electron beam. The materials tested include: (1) laminated Kevlar 49/polyester and E-glass/polyester composites, (2) a low density laminated Kevlar 49 composite, and (3) two types of through-the-thickness reinforced Kevlar 49 composites. As expected, tests using laminated Kevlar 49/polyester shields showed that shield permanent set (i.e., permanent deflection) increased with increasing tantalum conversion foil thickness and decreased with increasing shield thickness. The through-the-thickness reinforced composites developed localized, but severe, back surface damage. The laminated composites displayed little back surface damage, although extensive internal matrix cracking and ply delaminations were generated. Roughly the same degree of permanent set was produced in shields made from the low density Kevlar 49 composite and the Kevlar 49/polyester. The E-glass reinforced shields exhibited relatively low levels of permanent set

  13. The potential of SGLT2 inhibitors in phase II clinical development for treating type 2 diabetes.

    Science.gov (United States)

    Pafili, K; Maltezos, E; Papanas, N

    2016-10-01

    There is now an abundance of anti-diabetic agents. However, only few patients achieve glycemic targets. Moreover, current glucose-lowering agents mainly depend upon insulin secretion or function. Sodium glucose co-transporter type 2 (SGLT2) inhibitors present a novel glucose-lowering therapy, inducing glycosuria in an insulin-independent fashion. In this review, the authors discuss the key efficacy and safety data from phase II clinical trials in type 2 diabetes mellitus (T2DM) of the main SGLT2 inhibitors approved or currently in development, and provide a rationale for their use in T2DM. Despite the very promising characteristics of this new therapeutic class, a number of issues await consideration. One important question is what to expect from head-to-head comparison data. We also need to know if dual inhibition of SGLT1/SGLT2 is more efficacious in reducing HbA1c and how this therapy affects metabolic and cardiovascular parameters. Additionally, several SGLT2 agents that have not yet come to market have hitherto been evaluated in Asian populations, whereas approved SGLT2 inhibitors have been frequently studied in other populations, including Caucasian subjects. Thus, we need more information on the potential role of ethnicity on their efficacy and safety.

  14. Potential Malaysia agricultural waste materials for the biosorption of cadmium(II) from aqueous solution

    Energy Technology Data Exchange (ETDEWEB)

    Foo, L.P.Y.; Tee, C.Z.; Raimy, N.R.; Hassell, D.G.; Lee, L.Y. [University of Nottingham Malaysia Campus, Semenyih, Selangor (Malaysia)

    2012-04-15

    Biosorption of cadmium(II) ions (Cd{sup 2+}) onto Ananas comosus (AC) peel, Parkia speciosa (PS) pods and Psidium guajava (PG) peel were investigated in this study. Batch sorption experiments were performed by investigating the effect of initial pH. It was found that Cd{sup 2+} uptake was highly dependent on the initial pH and Cd{sup 2+} removal efficiency was highest for PG peel, followed by AC peel and PS pods. Biosorption experiments were carried out using different initial Cd{sup 2+} concentration and the experimental data obtained was fitted to both Langmuir and Freundlich isotherms. The experimental data was found to best fit the Langmuir isotherm, and adsorption capacities of 18.21 mg/g (AC peel), 25.64 mg/g (PS pods) and 39.68 mg/g (PG peel) were obtained. Comparison with published adsorption capacities for other low-cost biosorbents indicates that PS pods and PG peel have potential as low-cost biosorbent materials for the removal of Cd{sup 2+} from aqueous solution. (orig.)

  15. The Potential Economic Impact of Electricity Restructuring in the State of Oklahoma: Phase II Report; FINAL

    International Nuclear Information System (INIS)

    Hadley, SW

    2001-01-01

    In April 1997, the Oklahoma legislature passed a bill to restructure the state's electric industry, requiring that the generation sector be deregulated and allowing retail competition by July 2002. Details of the market structure were to be established later. Senate Bill No.220, introduced in the 2000 legislature, provided additional details on this market, but the bill did not pass. Subsequent discussions have identified the need for an objective analysis of the impact of restructuring on electricity prices and the state's economy, especially considering the experiences of other states following restructuring of their electric systems. Because of the recent experiences of other states undergoing restructuring (e.g., higher prices, greater volatility, lower reliability), concerns have been raised in states currently considering restructuring as to whether their systems are equally vulnerable. Factors such as local generation costs, transmission constraints, market concentration, and market design can all play a role in the success or failure of the market. Energy and ancillary services markets both play a role in having a well-functioning system. Customer responsiveness to market signals can enhance the flexibility of the market. The purpose of this project is to provide a model and process to evaluate the potential price and economic impacts of restructuring the Oklahoma electric industry. The goal is to provide sufficient objective analysis to the Oklahoma legislature that they may make a more informed decision on the timing and details of any future restructuring. It will also serve to inform other stakeholders on the economic issues surrounding restructuring. The project is being conducted in two phases. The Phase I report (Hadley 2001) concentrated on providing an analysis of the Oklahoma system in the near-term, using only present generation and transmission resources. This Phase II report looks further in the future, incorporating the potential of new

  16. Exactly solvable nonequilibrium Langevin relaxation of a trapped nanoparticle

    International Nuclear Information System (INIS)

    Salazar, Domingos S P; Lira, Sérgio A

    2016-01-01

    In this work, we study the nonequilibrium statistical properties of the relaxation dynamics of a nanoparticle trapped in a harmonic potential. We report an exact time-dependent analytical solution to the Langevin dynamics that arises from the stochastic differential equation of our system’s energy in the underdamped regime. By utilizing this stochastic thermodynamics approach, we are able to completely describe the heat exchange process between the nanoparticle and the surrounding environment. As an important consequence of our results, we observe the validity of the heat exchange fluctuation theorem in our setup, which holds for systems arbitrarily far from equilibrium conditions. By extending our results for the case of N noninterating nanoparticles, we perform analytical asymptotic limits and direct numerical simulations that corroborate our analytical predictions. (paper)

  17. Abnormalities in auditory evoked potentials of 75 patients with Arnold-Chiari malformations types I and II

    Directory of Open Access Journals (Sweden)

    Henriques Filho Paulo Sergio A.

    2006-01-01

    Full Text Available OBJECTIVE: To evaluate the frequency and degree of severity of abnormalities in the auditory pathways in patients with Chiari malformations type I and II. METHOD: This is a series-of-case descriptive study in which the possible presence of auditory pathways abnormalities in 75 patients (48 children and 27 adults with Chiari malformation types I and II were analyzed by means of auditory evoked potentials evaluation. The analysis was based on the determination of intervals among potentials peak values, absolute latency and amplitude ratio among potentials V and I. RESULTS: Among the 75 patients studied, 27 (36% disclosed Arnold-Chiari malformations type I and 48 (64% showed Arnold-Chiari malformations type II. Fifty-three (71% of these patients showed some degree of auditory evoked potential abnormalities. Tests were normal in the remaining 22 (29% patients. CONCLUSION: Auditory evoked potentials testing can be considered a valuable instrument for diagnosis and evaluation of brain stem functional abnormalities in patients with Arnold-Chiari malformations type I and II. The determination of the presence and degree of severity of these abnormalities can be contributory to the prevention of further handicaps in these patients either through physical therapy or by means of precocious corrective surgical intervention.

  18. Solvable lattice models with minimal and nonunitary critical behaviour in two dimensions

    International Nuclear Information System (INIS)

    Riggs, H.; Chicago Univ., IL

    1989-01-01

    The exact local height probabilities found by Forrester and Baxter for a series of solvable lattice models in two dimensions are written in terms of nonunitary Virasoro characters and modifications of unitary A 1 (1) affine Lie algebra characters directly related to nonunitary but rational-level A 1 (1) characters. The relation between these results and a rational-level GKO decomposition is given. The off-critical lattice origin of the Virasoro characters and the role of the embedding diagram null vectors in the CTM eigenspace is described. Suggestions for the definition of rational and nonunitary models corresponding to arbitrary G/H cosets are given. (orig.)

  19. Coherent states for a polynomial su(1, 1) algebra and a conditionally solvable system

    International Nuclear Information System (INIS)

    Sadiq, Muhammad; Inomata, Akira; Junker, Georg

    2009-01-01

    In a previous paper (2007 J. Phys. A: Math. Theor. 40 11105), we constructed a class of coherent states for a polynomially deformed su(2) algebra. In this paper, we first prepare the discrete representations of the nonlinearly deformed su(1, 1) algebra. Then we extend the previous procedure to construct a discrete class of coherent states for a polynomial su(1, 1) algebra which contains the Barut-Girardello set and the Perelomov set of the SU(1, 1) coherent states as special cases. We also construct coherent states for the cubic algebra related to the conditionally solvable radial oscillator problem.

  20. Classical and quantum contents of solvable game theory on Hilbert space

    International Nuclear Information System (INIS)

    Cheon, Taksu; Tsutsui, Izumi

    2006-01-01

    A simple and general formulation of the quantum game theory is presented, accommodating all possible strategies in the Hilbert space for the first time. The theory is solvable for the two strategy quantum game, which is shown to be equivalent to a family of classical games supplemented by quantum interference. Our formulation gives a clear perspective to understand why and how quantum strategies outmaneuver classical strategies. It also reveals novel aspects of quantum games such as the stone-scissor-paper phase sub-game and the fluctuation-induced moderation

  1. Chiral dynamics and heavy quark symmetry in a solvable toy field-theoretic model

    International Nuclear Information System (INIS)

    Bardeen, W.A.; Hill, C.T.

    1994-01-01

    We study a solvable QCD-like toy theory, a generalization of the Nambu--Jona-Lasinio model, which implements chiral symmetries of light quarks and heavy quark symmetry. The chiral symmetric and chiral broken phases can be dynamically tuned. This implies a parity-doubled heavy-light meson system, corresponding to a (0 - ,1 - ) multiplet and a (0 + ,1 + ) heavy spin multiplet. Consequently the mass difference of the two multiplets is given by a Goldberger-Treiman relation and g A is found to be small. The Isgur-Wise function ξ(w), the decay constant f B , and other observables are studied

  2. Quasi-exact solvability of the one-dimensional Holstein model

    International Nuclear Information System (INIS)

    Pan Feng; Dai Lianrong; Draayer, J P

    2006-01-01

    The one-dimensional Holstein model of spinless fermions interacting with dispersionless phonons is solved by using a Bethe ansatz in analogue to that for the one-dimensional spinless Fermi-Hubbard model. Excitation energies and the corresponding wavefunctions of the model are determined by a set of partial differential equations. It is shown that the model is, at least, quasi-exactly solvable for the two-site case, when the phonon frequency, the electron-phonon coupling strength and the hopping integral satisfy certain relations. As examples, some quasi-exact solutions of the model for the two-site case are derived. (letter to the editor)

  3. Conditions for the Solvability of the Linear Programming Formulation for Constrained Discounted Markov Decision Processes

    Energy Technology Data Exchange (ETDEWEB)

    Dufour, F., E-mail: dufour@math.u-bordeaux1.fr [Institut de Mathématiques de Bordeaux, INRIA Bordeaux Sud Ouest, Team: CQFD, and IMB (France); Prieto-Rumeau, T., E-mail: tprieto@ccia.uned.es [UNED, Department of Statistics and Operations Research (Spain)

    2016-08-15

    We consider a discrete-time constrained discounted Markov decision process (MDP) with Borel state and action spaces, compact action sets, and lower semi-continuous cost functions. We introduce a set of hypotheses related to a positive weight function which allow us to consider cost functions that might not be bounded below by a constant, and which imply the solvability of the linear programming formulation of the constrained MDP. In particular, we establish the existence of a constrained optimal stationary policy. Our results are illustrated with an application to a fishery management problem.

  4. Two novel classes of solvable many-body problems of goldfish type with constraints

    Energy Technology Data Exchange (ETDEWEB)

    Calogero, F [Dipartimento di Fisica, Universita di Roma ' La Sapienza' , 00185 Rome (Italy); Gomez-Ullate, D [Departamento de Fisica Teorica II, Universidad Complutense, 28040 Madrid (Spain)

    2007-05-18

    Two novel classes of many-body models with nonlinear interactions 'of goldfish type' are introduced. They are solvable provided the initial data satisfy a single constraint (in one case; in the other, two constraints), i.e., for such initial data the solution of their initial-value problem can be achieved via algebraic operations, such as finding the eigenvalues of given matrices or equivalently the zeros of known polynomials. Entirely isochronous versions of some of these models are also exhibited, i.e., versions of these models whose nonsingular solutions are all completely periodic with the same period.

  5. Quasi-exactly solvable relativistic soft-core Coulomb models

    Energy Technology Data Exchange (ETDEWEB)

    Agboola, Davids, E-mail: davagboola@gmail.com; Zhang, Yao-Zhong, E-mail: yzz@maths.uq.edu.au

    2012-09-15

    By considering a unified treatment, we present quasi exact polynomial solutions to both the Klein-Gordon and Dirac equations with the family of soft-core Coulomb potentials V{sub q}(r)=-Z/(r{sup q}+{beta}{sup q}){sup 1/q}, Z>0, {beta}>0, q{>=}1. We consider cases q=1 and q=2 and show that both cases are reducible to the same basic ordinary differential equation. A systematic and closed form solution to the basic equation is obtained using the Bethe ansatz method. For each case, the expressions for the energies and the allowed parameters are obtained analytically and the wavefunctions are derived in terms of the roots of a set of Bethe ansatz equations. - Highlights: Black-Right-Pointing-Pointer The relativistic bound-state solutions of the soft-core Coulomb models. Black-Right-Pointing-Pointer Quasi-exact treatments of the Dirac and Klein-Gordon equations for the soft-core Coulomb models. Black-Right-Pointing-Pointer Solutions obtained in terms of the roots to the Bethe ansatz equations. Black-Right-Pointing-Pointer The hidden Lie algebraic structure discussed for the models. Black-Right-Pointing-Pointer Results useful in describing mesonic atoms and interaction of intense laser fields with atom.

  6. Pressure in an exactly solvable model of active fluid

    Science.gov (United States)

    Marini Bettolo Marconi, Umberto; Maggi, Claudio; Paoluzzi, Matteo

    2017-07-01

    We consider the pressure in the steady-state regime of three stochastic models characterized by self-propulsion and persistent motion and widely employed to describe the behavior of active particles, namely, the Active Brownian particle (ABP) model, the Gaussian colored noise (GCN) model, and the unified colored noise approximation (UCNA) model. Whereas in the limit of short but finite persistence time, the pressure in the UCNA model can be obtained by different methods which have an analog in equilibrium systems, in the remaining two models only the virial route is, in general, possible. According to this method, notwithstanding each model obeys its own specific microscopic law of evolution, the pressure displays a certain universal behavior. For generic interparticle and confining potentials, we derive a formula which establishes a correspondence between the GCN and the UCNA pressures. In order to provide explicit formulas and examples, we specialize the discussion to the case of an assembly of elastic dumbbells confined to a parabolic well. By employing the UCNA we find that, for this model, the pressure determined by the thermodynamic method coincides with the pressures obtained by the virial and mechanical methods. The three methods when applied to the GCN give a pressure identical to that obtained via the UCNA. Finally, we find that the ABP virial pressure exactly agrees with the UCNA and GCN results.

  7. Spectral transform and solvability of nonlinear evolution equations

    International Nuclear Information System (INIS)

    Degasperis, A.

    1979-01-01

    These lectures deal with an exciting development of the last decade, namely the resolving method based on the spectral transform which can be considered as an extension of the Fourier analysis to nonlinear evolution equations. Since many important physical phenomena are modeled by nonlinear partial wave equations this method is certainly a major breakthrough in mathematical physics. We follow the approach, introduced by Calogero, which generalizes the usual Wronskian relations for solutions of a Sturm-Liouville problem. Its application to the multichannel Schroedinger problem will be the subject of these lectures. We will focus upon dynamical systems described at time t by a multicomponent field depending on one space coordinate only. After recalling the Fourier technique for linear evolution equations we introduce the spectral transform method taking the integral equations of potential scattering as an example. The second part contains all the basic functional relationships between the fields and their spectral transforms as derived from the Wronskian approach. In the third part we discuss a particular class of solutions of nonlinear evolution equations, solitons, which are considered by many physicists as a first step towards an elementary particle theory, because of their particle-like behaviour. The effect of the polarization time-dependence on the motion of the soliton is studied by means of the corresponding spectral transform, leading to new concepts such as the 'boomeron' and the 'trappon'. The rich dynamic structure is illustrated by a brief report on the main results of boomeron-boomeron and boomeron-trappon collisions. In the final section we discuss further results concerning important properties of the solutions of basic nonlinear equations. We introduce the Baecklund transform for the special case of scalar fields and demonstrate how it can be used to generate multisoliton solutions and how the conservation laws are obtained. (HJ)

  8. Application of quasiexactly solvable potential method to the N-body ...

    Indian Academy of Sciences (India)

    2015-11-27

    Proceedings of the International Workshop/Conference on Computational Condensed Matter Physics and Materials Science (IWCCMP-2015). Posted on November 27, 2015. Guest Editors: Anurag Srivastava, C. S. Praveen, H. S. Tewari. © 2015 Indian Academy of Sciences, Bengaluru. Contact | Site index.

  9. Landscape Potential Analysis for Ecotourism Destination in the Resort Ii Salak Mountain, Halimun-Salak National Park

    Science.gov (United States)

    Kusumoarto, A.; Gunawan, A.; Nurazizah, G. R.

    2017-10-01

    The Resort II Salak Mountain has variety of landscape potential for created as ecotourism destination, especially the potential of the waterfall (curug) and sulphur crater (Kawah Ratu). The aim of this study was to identify and analyze the potential resources of the landscape to be created as ecotourism destination, Resort II Salak Mountain. This research was conducted through two phases: 1) identification of the attractions location that have potential resources for ecotourism destination, and 2) analysis of the level of potential resource of the landscape in each location using Analysis of Tourist Attraction Operational Destination (ATAOD). The study showed Resort II Salak Mountain has many ecotourism objects which have been used for ecotourism activities, such as hot spring baths, Curug Cigamea, Curug Ngumpet, Curug Seribu, Curug Pangeran, Curug Muara, Curug Cihurang, Kawah Ratu, camping ground, Curug Kondang and Curug Alami. The location of all waterfalls -curug, spread widely in the core zone for ecotourism. In the other hand, camping ground is located in the business zone, while Kawah Ratu is located in the natural forest, which is included in the buffer zone of Halimun-Salak National Park (HSNP). The result showed that the ecotourism objects with the highest potential value are Kawah Ratu, Curug Seribu, Curug Muara, Curug Kondang and Curug Ngumpet.

  10. Quasi-exact solvability and entropies of the one-dimensional regularised Calogero model

    Science.gov (United States)

    Pont, Federico M.; Osenda, Omar; Serra, Pablo

    2018-05-01

    The Calogero model can be regularised through the introduction of a cutoff parameter which removes the divergence in the interaction term. In this work we show that the one-dimensional two-particle regularised Calogero model is quasi-exactly solvable and that for certain values of the Hamiltonian parameters the eigenfunctions can be written in terms of Heun’s confluent polynomials. These eigenfunctions are such that the reduced density matrix of the two-particle density operator can be obtained exactly as well as its entanglement spectrum. We found that the number of non-zero eigenvalues of the reduced density matrix is finite in these cases. The limits for the cutoff distance going to zero (Calogero) and infinity are analysed and all the previously obtained results for the Calogero model are reproduced. Once the exact eigenfunctions are obtained, the exact von Neumann and Rényi entanglement entropies are studied to characterise the physical traits of the model. The quasi-exactly solvable character of the model is assessed studying the numerically calculated Rényi entropy and entanglement spectrum for the whole parameter space.

  11. Relativistic model-potential oscillator strengths and transition probabilities for 4fsup(n)6s-4fsup(n)6p transitions in Eu(II), Tb(II), and Ho(II) in J1j coupling

    International Nuclear Information System (INIS)

    Migdalek, J.

    1984-01-01

    The lowest 4fsup(n)6s-4fsup(n)6p transitions are studied for the Eu(II) (n=7), Tb(II) (n=9), and Ho(II) (n=11) spectra, where the J 1 J coupling is an acceptable approximation. The relativistic radial integrals, required to evaluate the oscillator strengths and transition probabilities, are calculated with the model-potential method, which includes also core-polarization effects. The similarities observed in oscillator strengths for transitions with given ΔJ but different J values are discussed and explained. The computed oscillator strengths are compared with those obtained with the Coulomb approximation and it is found that the latter are only 11-12% lower. The core polarization influence on oscillator strengths is also investigated and the 19-21% decrease in oscillator strengths due to this effect is predicted. This result may, however, be overestimated because of some deficiencies in our procedure. (author)

  12. Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons

    Directory of Open Access Journals (Sweden)

    Smith Paula L

    2011-09-01

    Full Text Available Abstract Background Voltage-gated sodium channels play key roles in acute and chronic pain processing. The molecular, biophysical, and pharmacological properties of sodium channel currents have been extensively studied for peripheral nociceptors while the properties of sodium channel currents in dorsal horn spinal cord neurons remain incompletely understood. Thus far, investigations into the roles of sodium channel function in nociceptive signaling have primarily focused on recombinant channels or peripheral nociceptors. Here, we utilize recordings from lamina I/II neurons withdrawn from the surface of spinal cord slices to systematically determine the functional properties of sodium channels expressed within the superficial dorsal horn. Results Sodium channel currents within lamina I/II neurons exhibited relatively hyperpolarized voltage-dependent properties and fast kinetics of both inactivation and recovery from inactivation, enabling small changes in neuronal membrane potentials to have large effects on intrinsic excitability. By combining biophysical and pharmacological channel properties with quantitative real-time PCR results, we demonstrate that functional sodium channel currents within lamina I/II neurons are predominantly composed of the NaV1.2 and NaV1.3 isoforms. Conclusions Overall, lamina I/II neurons express a unique combination of functional sodium channels that are highly divergent from the sodium channel isoforms found within peripheral nociceptors, creating potentially complementary or distinct ion channel targets for future pain therapeutics.

  13. Solvability conditions for non-local boundary value problems for two-dimensional half-linear differential systems

    Czech Academy of Sciences Publication Activity Database

    Kiguradze, I.; Šremr, Jiří

    2011-01-01

    Roč. 74, č. 17 (2011), s. 6537-6552 ISSN 0362-546X Institutional research plan: CEZ:AV0Z10190503 Keywords : half-linear differential system * non-local boundary value problem * solvability Subject RIV: BA - General Mathematics Impact factor: 1.536, year: 2011 http://www.sciencedirect.com/science/article/pii/S0362546X11004573

  14. Solvability conditions of the Cauchy problem for two-dimensional systems of linear functional differential equations with monotone operators

    Czech Academy of Sciences Publication Activity Database

    Šremr, Jiří

    2007-01-01

    Roč. 132, č. 3 (2007), s. 263-295 ISSN 0862-7959 R&D Projects: GA ČR GP201/04/P183 Institutional research plan: CEZ:AV0Z10190503 Keywords : system of functional differential equations with monotone operators * initial value problem * unique solvability Subject RIV: BA - General Mathematics

  15. Investigation on Pleurotus ferulae potential for the sorption of Pb(II ...

    African Journals Online (AJOL)

    Pleurotus ferulae obtained from rotten tree was collected, washed, dried, ground and sieved to appropriate particle size. Infra-red spectrometry was used to determine functional groups on the biomass while biosorption of Pb(II) from aqueous solution was studied using the biomass in a batch system. The effect of pH (1-7.5), ...

  16. Ab initio effective core potentials including relativistic effects. II. Potential energy curves for Xe2, Xe+2, and Xe*2

    International Nuclear Information System (INIS)

    Ermler, W.C.; Lee, Y.S.; Pitzer, K.S.; Winter, N.W.

    1978-01-01

    Potential energy curves for the ground 1 Σ + /sub g/ state of Xe 2 , the first four states of the Xe + 2 ions, and the eight Xe* 2 excimer states corresponding to the addition of a 6ssigma/sub g/ Rydberg electron to these ion cores have been computed using averaged relativistic effective core potentials (AREP) and the self-consistent field approximation for the valence electrons. The calculations were carried out using the LS-coupling scheme with the effects of spin--orbit coupling included in the resulting potential energy curves using an empirical procedure. A comparison of nonrelativistic and averaged relativistic EP's and subsequent molecular calculations indicates that relativistic effects arising from the mass--velocity and Darwin terms are not important for these properties of Xe 2 molecules. Spectroscopic constants for Xe + 2 are in good agreement with all electron CI calculations suggesting that the computed values for Xe* 2 excimers should be reliable. The lifetime for the O/sub u/ + state of the Xe 2 * is computed to be 5.6 nsec which is in the range of the experimentally determined values

  17. External Cooling of the BWR Mark I and II Drywell Head as a Potential Accident Mitigation Measure - Scoping Assessment

    International Nuclear Information System (INIS)

    Robb, Kevin R.

    2017-01-01

    This report documents a scoping assessment of a potential accident mitigation action applicable to the US fleet of boiling water reactors with Mark I and II containments. The mitigation action is to externally flood the primary containment vessel drywell head using portable pumps or other means. A scoping assessment of the potential benefits of this mitigation action was conducted focusing on the ability to (1) passively remove heat from containment, (2) prevent or delay leakage through the drywell head seal (due to high temperatures and/or pressure), and (3) scrub radionuclide releases if the drywell head seal leaks.

  18. External Cooling of the BWR Mark I and II Drywell Head as a Potential Accident Mitigation Measure – Scoping Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Robb, Kevin R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-08-01

    This report documents a scoping assessment of a potential accident mitigation action applicable to the US fleet of boiling water reactors with Mark I and II containments. The mitigation action is to externally flood the primary containment vessel drywell head using portable pumps or other means. A scoping assessment of the potential benefits of this mitigation action was conducted focusing on the ability to (1) passively remove heat from containment, (2) prevent or delay leakage through the drywell head seal (due to high temperatures and/or pressure), and (3) scrub radionuclide releases if the drywell head seal leaks.

  19. Synthesis and Biological Evaluation of Ru(II) and Pt(II) Complexes Bearing Carboxyl Groups as Potential Anticancer Targeted Drugs.

    Science.gov (United States)

    Martínez, Ma Ángeles; Carranza, M Pilar; Massaguer, Anna; Santos, Lucia; Organero, Juan A; Aliende, Cristina; de Llorens, Rafael; Ng-Choi, Iteng; Feliu, Lidia; Planas, Marta; Rodríguez, Ana M; Manzano, Blanca R; Espino, Gustavo; Jalón, Félix A

    2017-11-20

    The synthesis and characterization of Pt(II) (1 and 2) and Ru(II) arene (3 and 4) or polypyridine (5 and 6) complexes is described. With the aim of having a functional group to form bioconjugates, one uncoordinated carboxyl group has been introduced in all complexes. Some of the complexes were selected for their potential in photodynamic therapy (PDT). The molecular structures of complexes 2 and 5, as well as that of the sodium salt of the 4'-(4-carboxyphenyl)-2,2':6',2″-terpyridine ligand (cptpy), were determined by X-ray diffraction. Different techniques were used to evaluate the binding capacity to model DNA molecules, and MTT cytotoxicity assays were performed against four cell lines. Compounds 3, 4, and 5 showed little tendency to bind to DNA and exhibited poor biological activity. Compound 2 behaves as bonded to DNA probably through a covalent interaction, although its cytotoxicity was very low. Compound 1 and possibly 6, both of which contain a cptpy ligand, were able to intercalate with DNA, but toxicity was not observed for 6. However, compound 1 was active in all cell lines tested. Clonogenic assays and apoptosis induction studies were also performed on the PC-3 line for 1. The photodynamic behavior for complexes 1, 5, and 6 indicated that their nuclease activity was enhanced after irradiation at λ = 447 nm. The cell viability was significantly reduced only in the case of 5. The different behavior in the absence or presence of light makes complex 5 a potential prodrug of interest in PDT. Molecular docking studies followed by molecular dynamics simulations for 1 and the counterpart without the carboxyl group confirmed the experimental data that pointed to an intercalation mechanism. The cytotoxicity of 1 and the potential of 5 in PDT make them good candidates for subsequent conjugation, through the carboxyl group, to "selected peptides" which could facilitate the selective vectorization of the complex toward receptors that are overexpressed in

  20. Construction of analytically solvable models for interacting species. [biological species competition

    Science.gov (United States)

    Rosen, G.

    1976-01-01

    The basic form of a model representation for systems of n interacting biological species is a set of essentially nonlinear autonomous ordinary differential equations. A generic canonical expression for the rate functions in the equations is reported which permits the analytical general solution to be obtained by elementary computation. It is shown that a general analytical solution is directly obtainable for models where the rate functions are prescribed by the generic canonical expression from the outset. Some illustrative examples are given which demonstrate that the generic canonical expression can be used to construct analytically solvable models for two interacting species with limit-cycle dynamics as well as for a three-species interdependence.

  1. E2-quasi-exact solvability for non-Hermitian models

    International Nuclear Information System (INIS)

    Fring, Andreas

    2015-01-01

    We propose the notion of E 2 -quasi-exact solvability and apply this idea to find explicit solutions to the eigenvalue problem for a non-Hermitian Hamiltonian system depending on two parameters. The model considered reduces to the complex Mathieu Hamiltonian in a double scaling limit, which enables us to compute the exceptional points in the energy spectrum of the latter as a limiting process of the zeros for some algebraic equations. The coefficient functions in the quasi-exact eigenfunctions are univariate polynomials in the energy obeying a three-term recurrence relation. The latter property guarantees the existence of a linear functional such that the polynomials become orthogonal. The polynomials are shown to factorize for all levels above the quantization condition leading to vanishing norms rendering them to be weakly orthogonal. In two concrete examples we compute the explicit expressions for the Stieltjes measure. (paper)

  2. E2-quasi-exact solvability for non-Hermitian models

    Science.gov (United States)

    Fring, Andreas

    2015-04-01

    We propose the notion of E2-quasi-exact solvability and apply this idea to find explicit solutions to the eigenvalue problem for a non-Hermitian Hamiltonian system depending on two parameters. The model considered reduces to the complex Mathieu Hamiltonian in a double scaling limit, which enables us to compute the exceptional points in the energy spectrum of the latter as a limiting process of the zeros for some algebraic equations. The coefficient functions in the quasi-exact eigenfunctions are univariate polynomials in the energy obeying a three-term recurrence relation. The latter property guarantees the existence of a linear functional such that the polynomials become orthogonal. The polynomials are shown to factorize for all levels above the quantization condition leading to vanishing norms rendering them to be weakly orthogonal. In two concrete examples we compute the explicit expressions for the Stieltjes measure.

  3. Integrability and solvability of the simplified two-qubit Rabi model

    International Nuclear Information System (INIS)

    Peng Jie; Ren Zhongzhou; Guo Guangjie; Ju Guoxing

    2012-01-01

    The simplified two-qubit Rabi model is proposed and its analytical solution is presented. There are no level crossings in the spectral graph of the model, which indicates that it is not integrable. The criterion of integrability for the Rabi model proposed by Braak (2011 Phys. Rev. Lett. 107 100401) is also used for the simplified two-qubit Rabi model and the same conclusion, consistent with what the spectral graph shows, can be drawn, which indicates that the criterion remains valid when applied to the two-qubit case. The simplified two-qubit Rabi model is another example of a non-integrable but exactly solvable system except for the generalized Rabi model. (paper)

  4. A new numerical approach for uniquely solvable exterior Riemann-Hilbert problem on region with corners

    Science.gov (United States)

    Zamzamir, Zamzana; Murid, Ali H. M.; Ismail, Munira

    2014-06-01

    Numerical solution for uniquely solvable exterior Riemann-Hilbert problem on region with corners at offcorner points has been explored by discretizing the related integral equation using Picard iteration method without any modifications to the left-hand side (LHS) and right-hand side (RHS) of the integral equation. Numerical errors for all iterations are converge to the required solution. However, for certain problems, it gives lower accuracy. Hence, this paper presents a new numerical approach for the problem by treating the generalized Neumann kernel at LHS and the function at RHS of the integral equation. Due to the existence of the corner points, Gaussian quadrature is employed which avoids the corner points during numerical integration. Numerical example on a test region is presented to demonstrate the effectiveness of this formulation.

  5. Dolan-Grady relations and noncommutative quasi-exactly solvable systems

    International Nuclear Information System (INIS)

    Klishevich, Sergey M; Plyushchay, Mikhail S

    2003-01-01

    We investigate a U(1) gauge invariant quantum mechanical system on a 2D noncommutative space with coordinates generating a generalized deformed oscillator algebra. The Hamiltonian is taken as a quadratic form in gauge covariant derivatives obeying the nonlinear Dolan-Grady relations. This restricts the structure function of the deformed oscillator algebra to a quadratic polynomial. The cases when the coordinates form the su(2) and sl(2,R) algebras are investigated in detail. Reducing the Hamiltonian to 1D finite-difference quasi-exactly solvable operators, we demonstrate partial algebraization of the spectrum of the corresponding systems on the fuzzy sphere and noncommutative hyperbolic plane. A completely covariant method based on the notion of intrinsic algebra is proposed to deal with the spectral problem of such systems

  6. Analytically solvable chaotic oscillator based on a first-order filter

    Energy Technology Data Exchange (ETDEWEB)

    Corron, Ned J.; Cooper, Roy M.; Blakely, Jonathan N. [Charles M. Bowden Laboratory, Aviation and Missile Research, Development and Engineering Center, U.S. Army RDECOM, Redstone Arsenal, Alabama 35898 (United States)

    2016-02-15

    A chaotic hybrid dynamical system is introduced and its analytic solution is derived. The system is described as an unstable first order filter subject to occasional switching of a set point according to a feedback rule. The system qualitatively differs from other recently studied solvable chaotic hybrid systems in that the timing of the switching is regulated by an external clock. The chaotic analytic solution is an optimal waveform for communications in noise when a resistor-capacitor-integrate-and-dump filter is used as a receiver. As such, these results provide evidence in support of a recent conjecture that the optimal communication waveform for any stable infinite-impulse response filter is chaotic.

  7. Solvability conditions for dendritic growth in the boundary-layer model with capillary anisotropy

    Science.gov (United States)

    Langer, J. S.; Hong, D. C.

    1986-01-01

    This paper is concerned primarily with the development of an analytic approach to the theory of steady-state velocity selection in the boundary-layer model of dendritic solidification. The two-dimensional version of this model with a fourfold crystalline anisotropy alpha in the surface tension is considered. By extending a WKB method introduced in an earlier paper, the alpha dependence of the selected growth rate is determined in the limit of small alpha; and this rate is studied for large alphas in the limit in which the dimensionless undercooling approaches unity. Portions of the paper are devoted to a reinterpretation of the mathematical structure of the solvability condition in problems of this kind.

  8. Fundamental solutions and local solvability for nonsmooth Hörmander’s operators

    CERN Document Server

    Bramanti, Marco; Manfredini, Maria

    2017-01-01

    The authors consider operators of the form L=\\sum_{i=1}^{n}X_{i}^{2}+X_{0} in a bounded domain of \\mathbb{R}^{p} where X_{0},X_{1},\\ldots,X_{n} are nonsmooth Hörmander's vector fields of step r such that the highest order commutators are only Hölder continuous. Applying Levi's parametrix method the authors construct a local fundamental solution \\gamma for L and provide growth estimates for \\gamma and its first derivatives with respect to the vector fields. Requiring the existence of one more derivative of the coefficients the authors prove that \\gamma also possesses second derivatives, and they deduce the local solvability of L, constructing, by means of \\gamma, a solution to Lu=f with Hölder continuous f. The authors also prove C_{X,loc}^{2,\\alpha} estimates on this solution.

  9. Potential safety enhancements to nuclear plant control: proof testing at EBR-II

    International Nuclear Information System (INIS)

    Lindsay, R.W.; Chisholm, G.H.

    1984-01-01

    Future changes in nuclear plant control and protective systems will reflect an evolutionary improvement through increased use of computers coupled with a better integration of man and machine. Before improvements can be accepted into the licensed commercial plant environment, significant testing must be accomplished to answer safety questions and to prove the worth of new ideas. The Experimental Breeder Reactor-II (EBR-II) is being used as a test-bed for both in-house development and testing for others in a DOE sponsored Man-Machine Integration program. The ultimate result of the development and testing would be a control system for which safety credit could be taken in the licensing process

  10. Novel copper (II) alginate hydrogels and their potential for use as anti-bacterial wound dressings

    International Nuclear Information System (INIS)

    Klinkajon, Wimonwan; Supaphol, Pitt

    2014-01-01

    The incorporation of a metal ion, with antimicrobial activity, into an alginate dressing is an attractive approach to minimize infection in a wound. In this work, copper (II) cross-linked alginate hydrogels were successfully prepared using a two-step cross-linking procedure. In the first step, solid alginate films were prepared using a solvent-casting method from soft gels of alginate solutions that had been lightly cross-linked using a copper (II) (Cu 2+ ) sulfate solution. In the second step, the films were further cross-linked in a corresponding Cu 2+ sulfate solution using a dipping method to further improve their dimensional stability. Alginate solution (at 2%w/v) and Cu 2+ sulfate solution (at 2%w/v) in acetate buffer at a low pH provided soft films with excellent swelling behavior. An increase in either Cu 2+ ion concentration or cross-linking time led to hydrogels with more densely-cross-linked networks that limited water absorption. The hydrogels clearly showed antibacterial activity against Escherichia coli, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis and Streptococcus pyogenes, which was proportional to the Cu 2+ ion concentration. Blood coagulation studies showed that the tested copper (II) cross-linked alginate hydrogels had a tendency to coagulate fibrin, and possibly had an effect on pro-thrombotic coagulation and platelet activation. Conclusively, the prepared films are likely candidates as antibacterial wound dressings. (paper)

  11. Countermeasures for electrolytic corrosion - Part II: Implementation of a rapid potential-controlled rectifier

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Tae-Hyun; Kim, Dae-Kyeong; Lee, Hyun-Goo; Ha, Yoon-Cheol; Bae, Jeong-Hyo [Underground Systems Group, Korea Electrotechnology Research Institute, 28-1 Sungju-dong, Changwon, 641-120 (Korea)

    2004-07-01

    In electrolytic interference circumstances such as underground pipelines in the vicinity of DC electrified railroads, drainage method or impressed current cathodic protection method has been widely used as a countermeasure for the electrolytic corrosion. In the former method, forced or polarized drainage is commonly adopted and in the latter, the phase-controlled rectifier with thyristor is in common use. Both methods, however, does not show as the optimal measure for the integrity of the pipeline, since the pipe-to-soil potential fluctuates highly positive to the cathodic protection criterion. In particular, as the potential of the pipeline near the railroad varies rapidly, a new rapidly responding countermeasure is necessary. In this paper, we introduce a new rapid potential controlled rectifier and report the result in field tests. Comparison with the existing forced drainage method is also made. The pipe-to-soil potential data show the effectiveness of the rapid potential-controlled rectifier. (authors)

  12. Rhodium (II) cycle alkanecarboxylate: synthesis, spectroscopic and thermo analytic studies and evaluation of the antitumor potential

    International Nuclear Information System (INIS)

    Souza, Aparecido Ribeiro de

    1995-01-01

    Four new rhodium(II) carboxylates (cyclopropane, cyclobutane, cyclopentane, and cyclohexanecarboxylate), and other already known rhodium (II) carboxylates (acetate, propionate, butyrate, metoxyacetate, dichloroacetate, and trifluoroacetate), have been prepared for study in this work. The compounds were characterized by elementary and thermogravimetric analysis, magnetic susceptibility, and electronic, Raman, and infrared spectroscopy. The reaction of Rh CL 3 .aq with the sodium carboxylates was studied aiming to improve the understanding of the redox process involved. Spectroscopy studies (Raman and electronic) were made to examine the transition involved in the Rh-Rh and Rh-O bonds. The results have shown a direct relation between the force of the carboxylic acid and the Rh-O force, but show a inverse relation with the Rh-Rh bond force. Thermal analysis studies were undertaken and the obtained date show a resemblance of the TG/DTG curves with that found in literature. In the other hand, the DSC curves show a different results: in open crucible, the peaks associated with the cage breakdown are exothermic and, in closed crucible this peaks are endothermic. The thermodecomposition products were analyzed. The evolved gases were identified by GC?MS and 1 H and 13 C NMR spectra. The residues were analyzed by X-ray diffraction. Antitumor activity of rhodium cyclopropanecarboxylate was evaluated in vitro (cell cultures K562 and Ehrlich) and in vivo (Balb-c mice with ascite Ehrlich tumor), indicating an increased life span (87.5%) of the treated animals. (author)

  13. Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation.

    Science.gov (United States)

    Michael, G; Dempster, J; Kane, K A; Coker, S J

    2007-12-01

    Torsade de pointes (TdP) can be induced by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether IKs blockade or enhancement of INa could potentiate TdP induced by IKr blockade and to investigate whether short-term variability (STV) or triangulation of action potentials preceded TdP. Experiments were performed in open-chest, pentobarbital-anaesthetized, alpha 1-adrenoceptor-stimulated, male New Zealand White rabbits, which received three consecutive i.v. infusions of either the IKr blocker E-4031 (1, 3 and 10 nmol kg(-1) min(-1)), the IKs blocker HMR1556 (25, 75 and 250 nmol kg(-1) min(-1)) or E-4031 and HMR1556 combined. In a second study rabbits received either the same doses of E-4031, the INa enhancer, ATX-II (0.4, 1.2 and 4.0 nmol kg(-1)) or both of these drugs. ECGs and epicardial monophasic action potentials were recorded. HMR1556 alone did not cause TdP but increased E-4031-induced TdP from 25 to 80%. ATX-II alone caused TdP in 38% of rabbits, as did E-4031; 75% of rabbits receiving both drugs had TdP. QT intervals were prolonged by all drugs but the extent of QT prolongation was not related to the occurrence of TdP. No changes in STV were detected and triangulation was only increased after TdP occurred. Giving modulators of ion channels in combination substantially increased TdP but, in this model, neither STV nor triangulation of action potentials could predict TdP.

  14. An assessment of BWR [boiling water reactor] Mark-II containment challenges, failure modes, and potential improvements in performance

    International Nuclear Information System (INIS)

    Kelly, D.L.; Jones, K.R.; Dallman, R.J.; Wagner, K.C.

    1990-07-01

    This report assesses challenges to BWR Mark II containment integrity that could potentially arise from severe accidents. Also assessed are some potential improvements that could prevent core damage or containment failure, or could mitigate the consequences of such failure by reducing the release of fission products to the environment. These challenges and improvements are analyzed via a limited quantitative risk/benefit analysis of a generic BWR/4 reactor with Mark II containment. Point estimate frequencies of the dominant core damage sequences are obtained and simple containment event trees are constructed to evaluate the response of the containment to these severe accident sequences. The resulting containment release modes are then binned into source term release categories, which provide inputs to the consequence analysis. The output of the consequences analysis is used to construct an overall base case risk profile. Potential improvements and sensitivities are evaluated by modifying the event tree spilt fractions, thus generating a revised risk profile. Several important sensitivity cases are examined to evaluate the impact of phenomenological uncertainties on the final results. 75 refs., 25 figs., 65 tabs

  15. Numerical Analysis of Blood Damage Potential of the HeartMate II and HeartWare HVAD Rotary Blood Pumps.

    Science.gov (United States)

    Thamsen, Bente; Blümel, Bastian; Schaller, Jens; Paschereit, Christian O; Affeld, Klaus; Goubergrits, Leonid; Kertzscher, Ulrich

    2015-08-01

    Implantable left ventricular assist devices (LVADs) became the therapy of choice in treating end-stage heart failure. Although survival improved substantially and is similar in currently clinically implanted LVADs HeartMate II (HM II) and HeartWare HVAD, complications related to blood trauma are frequently observed. The aim of this study was to compare these two pumps regarding their potential blood trauma employing computational fluid dynamics. High-resolution structured grids were generated for the pumps. Newtonian flow was calculated, solving Reynolds-averaged Navier-Stokes equations with a sliding mesh approach and a k-ω shear stress transport turbulence model for the operating point of 4.5 L/min and 80 mm Hg. The pumps were compared in terms of volumes subjected to certain viscous shear stress thresholds, below which no trauma was assumed (von Willebrand factor cleavage: 9 Pa, platelet activation: 50 Pa, and hemolysis: 150 Pa), and associated residence times. Additionally, a hemolysis index was calculated based on a Eulerian transport approach. Twenty-two percent of larger volumes above 9 Pa were observed in the HVAD; above 50 Pa and 150 Pa the differences between the two pumps were marginal. Residence times were higher in the HVAD for all thresholds. The hemolysis index was almost equal for the HM II and HVAD. Besides the gap regions in both pumps, the inlet regions of the rotor and diffuser blades have a high hemolysis production in the HM II, whereas in the HVAD, the volute tongue is an additional site for hemolysis production. Thus, in this study, the comparison of the HM II and the HVAD using numerical methods indicated an overall similar tendency to blood trauma in both pumps. However, influences of turbulent shear stresses were not considered and effects of the pivot bearing in the HM II were not taken into account. Further in vitro investigations are required. Copyright © 2015 International Center for Artificial Organs and Transplantation and

  16. Harmonic analysis and global solvability of a differential operator invariant on motion groups and semi-simple Lie groups

    International Nuclear Information System (INIS)

    El-Hussein, K.

    1991-08-01

    Let V be a real finite dimensional vector space and let K be a connected compact Lie group, which acts on V by means of a continuous linear representation ρ. Let G=V x p K be the motion group which is the semi-direct product of V by K and let P be an invariant differential operator on G. In this paper we give a necessary and sufficient condition for the global solvability of P on G. Now let G be a connected semi-simple Lie group with finite centre and let P be an invariant differential operator on G. We give also a necessary and sufficient condition for the global solvability of P on G. (author). 8 refs

  17. Single Particle Potential of a Σ Hyperon in Nuclear Matter. II Rearrangement Effects

    International Nuclear Information System (INIS)

    Dabrowski, J.

    2000-01-01

    The rearrangement contribution to the real part of the single particle potential of a Σ hyperon in nuclear matter, U Σ , is investigated. The isospin and spin dependent parts of U Σ are considered. Results obtained for four models of the Nijmegen baryon-baryon interaction are presented and discussed. (author)

  18. Reconciling semiclassical and Bohmian mechanics. II. Scattering states for discontinuous potentials

    International Nuclear Information System (INIS)

    Trahan, Corey; Poirier, Bill

    2006-01-01

    In a previous paper [B. Poirier, J. Chem. Phys. 121, 4501 (2004)] a unique bipolar decomposition, Ψ=Ψ 1 +Ψ 2 , was presented for stationary bound states Ψ of the one-dimensional Schroedinger equation, such that the components Ψ 1 and Ψ 2 approach their semiclassical WKB analogs in the large action limit. Moreover, by applying the Madelung-Bohm ansatz to the components rather than to Ψ itself, the resultant bipolar Bohmian mechanical formulation satisfies the correspondence principle. As a result, the bipolar quantum trajectories are classical-like and well behaved, even when Ψ has many nodes or is wildly oscillatory. In this paper, the previous decomposition scheme is modified in order to achieve the same desirable properties for stationary scattering states. Discontinuous potential systems are considered (hard wall, step potential, and square barrier/well), for which the bipolar quantum potential is found to be zero everywhere, except at the discontinuities. This approach leads to an exact numerical method for computing stationary scattering states of any desired boundary conditions, and reflection and transmission probabilities. The continuous potential case will be considered in a companion paper [C. Trahan and B. Poirier, J. Chem. Phys. 124, 034116 (2006), following paper

  19. Platinum(II)-gadolinium(III) complexes as potential single-molecular theranostic agents for cancer treatment.

    Science.gov (United States)

    Zhu, Zhenzhu; Wang, Xiaoyong; Li, Tuanjie; Aime, Silvio; Sadler, Peter J; Guo, Zijian

    2014-11-24

    Theranostic agents are emerging multifunctional molecules capable of simultaneous therapy and diagnosis of diseases. We found that platinum(II)-gadolinium(III) complexes with the formula [{Pt(NH3)2Cl}2GdL](NO3)2 possess such properties. The Gd center is stable in solution and the cytoplasm, whereas the Pt centers undergo ligand substitution in cancer cells. The Pt units interact with DNA and significantly promote the cellular uptake of Gd complexes. The cytotoxicity of the Pt-Gd complexes is comparable to that of cisplatin at high concentrations (≥0.1 mM), and their proton relaxivity is higher than that of the commercial magnetic resonance imaging (MRI) contrast agent Gd-DTPA. T1-weighted MRI on B6 mice demonstrated that these complexes can reveal the accumulation of platinum drugs in vivo. Their cytotoxicity and imaging capabilities make the Pt-Gd complexes promising theranostic agents for cancer treatment. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Potential of Brass to Remove Inorganic Hg(II) from Aqueous Solution through Amalgamation.

    Science.gov (United States)

    Wenke, Axel; Bollen, Anne; Richard, Jan-Helge; Biester, Harald

    2016-06-01

    Brass shavings (CuZn45) were tested for their efficiency to remove Hg(II) from contaminated groundwater through amalgamation. The study was focused on long-term retention efficiency, the understanding of the amalgamation process and kinetics, and influences of filter surface alteration. Column tests were performed with brass filters (thickness 3 to 9 cm) flushed with 1000 μg/L Hg solution for 8 hours under different flow rates (300 to 600 mL/h). Brass filters consistently removed >98% of Hg from solution independent of filter thickness and flow rate. In a long-term experiment (filter thickness 2 cm), Hg retention decreased from 96 to 92% within 2000 hours. Batch and column experiments for studying kinetics of Hg removal indicate ~100% Hg removal from solution within only 2 hours. Solid-phase mercury thermo-desorption analysis revealed that Hg(0) diffusion into the brass surface controls kinetics of mercury retention. Brass surface alteration could be observed, but did not influence Hg retention.

  1. DNA-Binding Studies of Some Potential Antitumor 2,2'-bipyridine Pt(II)/Pd(II) Complexes of piperidinedithiocarbamate. Their Synthesis, Spectroscopy and Cytotoxicity.

    Science.gov (United States)

    Mansouri-Torshizi, Hassan; Eslami-Moghadam, Mahboube; Divsalar, Adeleh; Saboury, Ali-Akbar

    2011-12-01

    In this study two platinum(II) and palladium(II) complexes of the type [M(bpy)(pip-dtc)]NO3 (where M=Pt(II) or Pd(II), bpy=2,2'-bipyridine, pip-dtc=piperidinedithiocarbamate) were synthesized by reaction between diaquo-2,2'-bipyridine Pt(II)/Pd(II) nitrate and sodium salt of dithiocarbamate. These cationic water soluble complexes were characterized by elemental analysis, molar conductance, IR, electronic and 1H NMR spectroscopic studies. The cyclic dithiocarbamate was found to coordinate as bidentate fasion with Pt(II) or Pd(II) center. Their biological activities were tested against chronic myelogenous leukemia cell line, K562, at micromolar concentration. The obtained cytotoxic concentration (IC50) values were much lower than cisplatin. The interaction of these complexes with highly polymerized calf thymus DNA (ct-DNA) was extensively studied by means of electronic absorption, fluorescence, circular dichroism and other measurements. The experimental results, thermodynamic and binding parameters, suggested that these complexes cooperatively bind to DNA presumably via intercalation. Moreover, the tendency of the Pt(II) complex to interact with DNA was more than that of Pd(II) complex.

  2. Metabolites from invasive pests inhibit mitochondrial complex II: A potential strategy for the treatment of human ovarian carcinoma?

    Energy Technology Data Exchange (ETDEWEB)

    Ferramosca, Alessandra, E-mail: alessandra.ferramosca@unisalento.it [Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Lecce (Italy); Conte, Annalea; Guerra, Flora; Felline, Serena [Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Lecce (Italy); Rimoli, Maria Grazia [Dipartimento di Farmacia, Università di Napoli Federico II, Napoli (Italy); Mollo, Ernesto [Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli (Italy); Zara, Vincenzo [Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Lecce (Italy); Terlizzi, Antonio [Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Lecce (Italy); Stazione Zoologica Anton Dohrn, Napoli (Italy)

    2016-05-13

    The red pigment caulerpin, a secondary metabolite from the marine invasive green algae Caulerpa cylindracea can be accumulated and transferred along the trophic chain, with detrimental consequences on biodiversity and ecosystem functioning. Despite increasing research efforts to understand how caulerpin modifies fish physiology, little is known on the effects of algal metabolites on mammalian cells. Here we report for the first time the mitochondrial targeting activity of both caulerpin, and its closely related derivative caulerpinic acid, by using as experimental model rat liver mitochondria, a system in which bioenergetics mechanisms are not altered. Mitochondrial function was tested by polarographic and spectrophotometric methods. Both compounds were found to selectively inhibit respiratory complex II activity, while complexes I, III, and IV remained functional. These results led us to hypothesize that both algal metabolites could be used as antitumor agents in cell lines with defects in mitochondrial complex I. Ovarian cancer cisplatin-resistant cells are a good example of cell lines with a defective complex I function on which these molecules seem to have a toxic effect on proliferation. This provided novel insight toward the potential use of metabolites from invasive Caulerpa species for the treatment of human ovarian carcinoma cisplatin-resistant cells. -- Highlights: •Novel insight toward the potential use of the algal metabolites for the treatment of human diseases. •Caulerpin and caulerpinic acid inhibit respiratory complex II activity. •Both algal metabolites could be used as antitumor agents in ovarian cancer cisplatin-resistant cells.

  3. Metabolites from invasive pests inhibit mitochondrial complex II: A potential strategy for the treatment of human ovarian carcinoma?

    International Nuclear Information System (INIS)

    Ferramosca, Alessandra; Conte, Annalea; Guerra, Flora; Felline, Serena; Rimoli, Maria Grazia; Mollo, Ernesto; Zara, Vincenzo; Terlizzi, Antonio

    2016-01-01

    The red pigment caulerpin, a secondary metabolite from the marine invasive green algae Caulerpa cylindracea can be accumulated and transferred along the trophic chain, with detrimental consequences on biodiversity and ecosystem functioning. Despite increasing research efforts to understand how caulerpin modifies fish physiology, little is known on the effects of algal metabolites on mammalian cells. Here we report for the first time the mitochondrial targeting activity of both caulerpin, and its closely related derivative caulerpinic acid, by using as experimental model rat liver mitochondria, a system in which bioenergetics mechanisms are not altered. Mitochondrial function was tested by polarographic and spectrophotometric methods. Both compounds were found to selectively inhibit respiratory complex II activity, while complexes I, III, and IV remained functional. These results led us to hypothesize that both algal metabolites could be used as antitumor agents in cell lines with defects in mitochondrial complex I. Ovarian cancer cisplatin-resistant cells are a good example of cell lines with a defective complex I function on which these molecules seem to have a toxic effect on proliferation. This provided novel insight toward the potential use of metabolites from invasive Caulerpa species for the treatment of human ovarian carcinoma cisplatin-resistant cells. -- Highlights: •Novel insight toward the potential use of the algal metabolites for the treatment of human diseases. •Caulerpin and caulerpinic acid inhibit respiratory complex II activity. •Both algal metabolites could be used as antitumor agents in ovarian cancer cisplatin-resistant cells.

  4. The Recording and Quantification of Event-Related Potentials: II. Signal Processing and Analysis

    Directory of Open Access Journals (Sweden)

    Paniz Tavakoli

    2015-06-01

    Full Text Available Event-related potentials are an informative method for measuring the extent of information processing in the brain. The voltage deflections in an ERP waveform reflect the processing of sensory information as well as higher-level processing that involves selective attention, memory, semantic comprehension, and other types of cognitive activity. ERPs provide a non-invasive method of studying, with exceptional temporal resolution, cognitive processes in the human brain. ERPs are extracted from scalp-recorded electroencephalography by a series of signal processing steps. The present tutorial will highlight several of the analysis techniques required to obtain event-related potentials. Some methodological issues that may be encountered will also be discussed.

  5. Quantum damped oscillator II: Bateman's Hamiltonian vs. 2D parabolic potential barrier

    International Nuclear Information System (INIS)

    Chruscinski, Dariusz

    2006-01-01

    We show that quantum Bateman's system which arises in the quantization of a damped harmonic oscillator is equivalent to a quantum problem with 2D parabolic potential barrier known also as 2D inverted isotropic oscillator. It turns out that this system displays the family of complex eigenvalues corresponding to the poles of analytical continuation of the resolvent operator to the complex energy plane. It is shown that this representation is more suitable than the hyperbolic one used recently by Blasone and Jizba

  6. A comparative study of semi-empirical interionic potentials for alkali halides - II

    International Nuclear Information System (INIS)

    Khwaja, F.A.; Naqvi, S.H.

    1985-08-01

    A comprehensive study of some semi-empirical interionic potentials is carried out through the calculation of the cohesive energy, relative stability and pressure induced solid-solid phase transformations in alkali halides. The theoretical values of these properties of the alkali halides are obtained using a new set of van der Waals coefficients and zero-point energy in the expression for interionic potential. From the comparison of the present calculations with some previous sophisticated ab-initio quantum-mechanical calculations and other semi-empirical approaches, it is concluded that the present calculations in the simplest central pairwise interaction description with the new values of the van der Waals coefficients and zero-point energy are in better agreement with the experimental data than the previous calculations. It is also concluded that in some cases the better choice of the interionic potential alone in the simplest semi-empirical picture of interaction gives an agreement of the theoretical predictions with the experimental data much superior to the ab-initio quantum mechanical approaches. (author)

  7. Study of diffuse H II regions potentially forming part of the gas streams around Sgr A*

    Science.gov (United States)

    Armijos-Abendaño, J.; López, E.; Martín-Pintado, J.; Báez-Rubio, A.; Aravena, M.; Requena-Torres, M. A.; Martín, S.; Llerena, M.; Aldás, F.; Logan, C.; Rodríguez-Franco, A.

    2018-05-01

    We present a study of diffuse extended ionized gas towards three clouds located in the Galactic Centre (GC). One line of sight (LOS) is towards the 20 km s-1 cloud (LOS-0.11) in the Sgr A region, another LOS is towards the 50 km s-1 cloud (LOS-0.02), also in Sgr A, while the third is towards the Sgr B2 cloud (LOS+0.693). The emission from the ionized gas is detected from Hnα and Hmβ radio recombination lines (RRLs). Henα and Hemβ RRL emission is detected with the same n and m as those from the hydrogen RRLs only towards LOS+0.693. RRLs probe gas with positive and negative velocities towards the two Sgr A sources. The Hmβ to Hnα ratios reveal that the ionized gas is emitted under local thermodynamic equilibrium conditions in these regions. We find a He to H mass fraction of 0.29±0.01 consistent with the typical GC value, supporting the idea that massive stars have increased the He abundance compared to its primordial value. Physical properties are derived for the studied sources. We propose that the negative velocity component of both Sgr A sources is part of gas streams considered previously to model the GC cloud kinematics. Associated massive stars with what are presumably the closest H II regions to LOS-0.11 (positive velocity gas), LOS-0.02, and LOS+0.693 could be the main sources of ultraviolet photons ionizing the gas. The negative velocity components of both Sgr A sources might be ionized by the same massive stars, but only if they are in the same gas stream.

  8. Hamiltonian formulation of systems with balanced loss-gain and exactly solvable models

    Science.gov (United States)

    Ghosh, Pijush K.; Sinha, Debdeep

    2018-01-01

    A Hamiltonian formulation of generic many-body systems with balanced loss and gain is presented. It is shown that a Hamiltonian formulation is possible only if the balancing of loss and gain terms occurs in a pairwise fashion. It is also shown that with the choice of a suitable co-ordinate, the Hamiltonian can always be reformulated in the background of a pseudo-Euclidean metric. If the equations of motion of some of the well-known many-body systems like Calogero models are generalized to include balanced loss and gain, it appears that the same may not be amenable to a Hamiltonian formulation. A few exactly solvable systems with balanced loss and gain, along with a set of integrals of motion are constructed. The examples include a coupled chain of nonlinear oscillators and a many-particle Calogero-type model with four-body inverse square plus two-body pair-wise harmonic interactions. For the case of nonlinear oscillators, stable solution exists even if the loss and gain parameter has unbounded upper range. Further, the range of the parameter for which the stable solutions are obtained is independent of the total number of the oscillators. The set of coupled nonlinear equations are solved exactly for the case when the values of all the constants of motions except the Hamiltonian are equal to zero. Exact, analytical classical solutions are presented for all the examples considered.

  9. Current fluctuations and statistics during a large deviation event in an exactly solvable transport model

    International Nuclear Information System (INIS)

    Hurtado, Pablo I; Garrido, Pedro L

    2009-01-01

    We study the distribution of the time-integrated current in an exactly solvable toy model of heat conduction, both analytically and numerically. The simplicity of the model allows us to derive the full current large deviation function and the system statistics during a large deviation event. In this way we unveil a relation between system statistics at the end of a large deviation event and for intermediate times. The mid-time statistics is independent of the sign of the current, a reflection of the time-reversal symmetry of microscopic dynamics, while the end-time statistics does depend on the current sign, and also on its microscopic definition. We compare our exact results with simulations based on the direct evaluation of large deviation functions, analyzing the finite-size corrections of this simulation method and deriving detailed bounds for its applicability. We also show how the Gallavotti–Cohen fluctuation theorem can be used to determine the range of validity of simulation results

  10. Does really Born-Oppenheimer approximation break down in charge transfer processes? An exactly solvable model

    International Nuclear Information System (INIS)

    Kuznetsov, Alexander M.; Medvedev, Igor G.

    2006-01-01

    Effects of deviation from the Born-Oppenheimer approximation (BOA) on the non-adiabatic transition probability for the transfer of a quantum particle in condensed media are studied within an exactly solvable model. The particle and the medium are modeled by a set of harmonic oscillators. The dynamic interaction of the particle with a single local mode is treated explicitly without the use of BOA. Two particular situations (symmetric and non-symmetric systems) are considered. It is shown that the difference between the exact solution and the true BOA is negligibly small at realistic parameters of the model. However, the exact results differ considerably from those of the crude Condon approximation (CCA) which is usually considered in the literature as a reference point for BOA (Marcus-Hush-Dogonadze formula). It is shown that the exact rate constant can be smaller (symmetric system) or larger (non-symmetric one) than that obtained in CCA. The non-Condon effects are also studied

  11. A solvable self-similar model of the sausage instability in a resistive Z pinch

    International Nuclear Information System (INIS)

    Lampe, M.

    1991-01-01

    A solvable model is developed for the linearized sausage mode within the context of resistive magnetohydrodynamics. The model is based on the assumption that the fluid motion of the plasma is self-similar, as well as several assumptions pertinent to the limit of wavelength long compared to the pinch radius. The perturbations to the magnetic field are not assumed to be self-similar, but rather are calculated. Effects arising from time dependences of the z-independent perturbed state, e.g., current rising as t α , Ohmic heating, and time variation of the pinch radius, are included in the analysis. The formalism appears to provide a good representation of ''global'' modes that involve coherent sausage distortion of the entire cross section of the pinch, but excludes modes that are localized radially, and higher radial eigenmodes. For this and other reasons, it is expected that the model underestimates the maximum instability growth rates, but is reasonable for global sausage modes. The net effect of resistivity and time variation of the unperturbed state is to decrease the growth rate if α approx-lt 1, but never by more than a factor of about 2. The effect is to increase the growth rate if α approx-gt 1

  12. Sine-square deformation of solvable spin chains and conformal field theories

    International Nuclear Information System (INIS)

    Katsura, Hosho

    2012-01-01

    We study solvable spin chains, one-dimensional massless Dirac fermions and conformal field theories (CFTs) with sine-square deformation (SSD), in which the Hamiltonian density is modulated by the function f(x) = sin  2 (πx/ℓ), where x is the position and ℓ is the length of the system. For the XY chain and the transverse field Ising chain at criticality, it is shown that the ground state of an open system with SSD is identical to that of a uniform chain with periodic boundary conditions. The same holds for the massless Dirac fermions with SSD, corresponding to the continuum limit of the gapless XY chain. For general CFTs, we find that the Hamiltonian of a system with SSD has an expression in terms of the generators of the Virasoro algebra. This allows us to show that the vacuum state is an exact eigenstate of the sine-square deformed Hamiltonian. Furthermore, for a restricted class of CFTs associated with affine Lie (Kac–Moody) algebras, including c = 1 Gaussian CFT, we prove that the vacuum is an exact ground state of the deformed Hamiltonian. This explains why the SSD has succeeded in suppressing boundary effects in one-dimensional critical systems, as observed in previous numerical studies. (paper)

  13. Filtering a statistically exactly solvable test model for turbulent tracers from partial observations

    International Nuclear Information System (INIS)

    Gershgorin, B.; Majda, A.J.

    2011-01-01

    A statistically exactly solvable model for passive tracers is introduced as a test model for the authors' Nonlinear Extended Kalman Filter (NEKF) as well as other filtering algorithms. The model involves a Gaussian velocity field and a passive tracer governed by the advection-diffusion equation with an imposed mean gradient. The model has direct relevance to engineering problems such as the spread of pollutants in the air or contaminants in the water as well as climate change problems concerning the transport of greenhouse gases such as carbon dioxide with strongly intermittent probability distributions consistent with the actual observations of the atmosphere. One of the attractive properties of the model is the existence of the exact statistical solution. In particular, this unique feature of the model provides an opportunity to design and test fast and efficient algorithms for real-time data assimilation based on rigorous mathematical theory for a turbulence model problem with many active spatiotemporal scales. Here, we extensively study the performance of the NEKF which uses the exact first and second order nonlinear statistics without any approximations due to linearization. The role of partial and sparse observations, the frequency of observations and the observation noise strength in recovering the true signal, its spectrum, and fat tail probability distribution are the central issues discussed here. The results of our study provide useful guidelines for filtering realistic turbulent systems with passive tracers through partial observations.

  14. C*-algebraic scattering theory and explicitly solvable quantum field theories

    International Nuclear Information System (INIS)

    Warchall, H.A.

    1985-01-01

    A general theoretical framework is developed for the treatment of a class of quantum field theories that are explicitly exactly solvable, but require the use of C*-algebraic techniques because time-dependent scattering theory cannot be constructed in any one natural representation of the observable algebra. The purpose is to exhibit mechanisms by which inequivalent representations of the observable algebra can arise in quantum field theory, in a setting free of other complications commonly associated with the specification of dynamics. One of two major results is the development of necessary and sufficient conditions for the concurrent unitary implementation of two automorphism groups in a class of quasifree representations of the algebra of the canonical commutation relations (CCR). The automorphism groups considered are induced by one-parameter groups of symplectic transformations on the classical phase space over which the Weyl algebra of the CCR is built; each symplectic group is conjugate by a fixed symplectic transformation to a one-parameter unitary group. The second result, an analog to the Birman--Belopol'skii theorem in two-Hilbert-space scattering theory, gives sufficient conditions for the existence of Moller wave morphisms in theories with time-development automorphism groups of the above type. In a paper which follows, this framework is used to analyze a particular model system for which wave operators fail to exist in any natural representation of the observable algebra, but for which wave morphisms and an associated S matrix are easily constructed

  15. Exactly solvable models of two-dimensional dilaton cosmology with quantum backreaction

    International Nuclear Information System (INIS)

    Zaslavskii, O B

    2003-01-01

    We consider a general approach to exactly solvable 2D dilaton cosmology with one-loop backreaction from conformal fields taken into account. It includes as particular cases previous models discussed in the literature. We list different types of solutions and investigate their properties for simple models, typical for string theory. We find a rather rich class of everywhere-regular solutions, which exist practically in every type of analysed solution. They exhibit different kinds of asymptotic behaviour in the past and future, including inflation, superinflation, deflation, power expansion or contraction. In particular, for some models the dS spacetime with a time-dependent dilaton field is the exact solution of the field equations. For some kinds of solution the weak-energy condition is violated independently of a specific model. We also find the solutions with a singularity which is situated in an infinite past (or future), so at any finite moment of a comoving time the universe is singularity-free. It is pointed out that for some models the spacetime may be everywhere regular even in spite of infinitely large quantum backreaction in an infinite past

  16. Quantum damped oscillator II: Bateman’s Hamiltonian vs. 2D parabolic potential barrier

    Science.gov (United States)

    Chruściński, Dariusz

    2006-04-01

    We show that quantum Bateman’s system which arises in the quantization of a damped harmonic oscillator is equivalent to a quantum problem with 2D parabolic potential barrier known also as 2D inverted isotropic oscillator. It turns out that this system displays the family of complex eigenvalues corresponding to the poles of analytical continuation of the resolvent operator to the complex energy plane. It is shown that this representation is more suitable than the hyperbolic one used recently by Blasone and Jizba.

  17. Analysis of potential saltwater intrusion at NEP I and II power station

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D.W.

    1980-06-01

    The potential of adverse environmental impacts to groundwater availability and groundwater quality from construction dewatering of the coastal aquifer at a proposed New England Power site was examined with an analytical model. The drawdown zone and the extent of saltwater intrusion were predicted with and without the use of a slurry-wall barrier. The use of a slurry wall to mitigate any adverse impacts is feasible but the limited understanding of the coastal aquifer demands that monitoring requirements be included in the construction plan.

  18. Analysis of potential saltwater intrusion at NEP I and II power station

    International Nuclear Information System (INIS)

    Lee, D.W.

    1980-06-01

    The potential of adverse environmental impacts to groundwater availability and groundwater quality from construction dewatering of the coastal aquifer at a proposed New England Power site was examined with an analytical model. The drawdown zone and the extent of saltwater intrusion were predicted with and without the use of a slurry-wall barrier. The use of a slurry wall to mitigate any adverse impacts is feasible but the limited understanding of the coastal aquifer demands that monitoring requirements be included in the construction plan

  19. SUSY formalism for the symmetric double well potential

    Indian Academy of Sciences (India)

    Using first- and second-order supersymmetric Darboüx formalism and starting with symmetric double well potential barrier we have obtained a class of exactly solvable potentials subject to moving boundary condition. The eigenstates are also obtained by the same technique.

  20. The Spectroscopic and Conductive Properties of Ru(II Complexes with Potential Anticancer Properties

    Directory of Open Access Journals (Sweden)

    Adebayo A. Adeniyi

    2014-01-01

    Full Text Available Different density functional methods (DFT have been used to optimize and study the chemistry of five potential anticancer complexes in terms of their electronic, conductive, and spectroscopic properties. Many of the computed properties in addition to the IR and QTAIM analysis of the NMR are dipole moment vector (μi, linear polarizability tensor (αij, first hyperpolarizability tensors (βijk, polarizability exaltation index (Γ, and chemical hardness (η of the complexes. Stable low energy geometries are obtained using basis set with effective core potential (ECP approximation but, in the computation of atomic or molecular properties, the metal Ru atom is better treated with higher all electron basis set like DGDZVP. The spectroscopic features like the IR of the metal-ligand bonds and the isotropic NMR shielding tensor of the coordinated atoms are significantly influenced by the chemical environment of the participating atoms. The carboxylic and pyrazole units are found to significantly enhance the polarizabilities and hyperpolarizabilities of the complexes while the chloride only improves the polarity of the complexes. Fermi contacts (FC have the highest effect followed by the PSO among all the four Ramsey terms which defined the total spin-spin coupling constant J (HZ of these complexes.

  1. The reduction of 4-chloronitrobenzene by Fe(II)-Fe(III) oxide systems - correlations with reduction potential and inhibition by silicate

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Adele M., E-mail: adele.jones1@unsw.edu.au; Kinsela, Andrew S.; Collins, Richard N.; Waite, T. David, E-mail: d.waite@unsw.edu.au

    2016-12-15

    Recent studies have demonstrated that the rate at which Fe(II)-Fe(III) oxyhydroxide systems catalyze the reduction of reducible contaminants, such as 4-chloronitrobenzene, is well correlated to their thermodynamic reduction potential. Here we confirm this effect in the presence of Fe(III) oxyhydroxide phases not previously assessed, namely ferrihydrite and nano-goethite, as well as Fe(III) oxyhydroxide phases previously examined. In addition, silicate is found to decrease the extent of Fe(II) sorption to the Fe(III) oxyhydroxide surface, increasing the reduction potential of the Fe(II)-Fe(III) oxyhydroxide suspension and, accordingly, decreasing the rate of 4-chloronitrobenzene reduction. A linear relationship between the reduction potential of the Fe(II)-Fe(III) oxyhydroxide suspensions and the reduction rate of 4-chloronitrobenzene (normalized to surface area and concentration of sorbed Fe(II)) was obtained in the presence and absence of silicate. However, when ferrihydrite was doped with Si (through co-precipitation) the reduction of 4-chloronitrobenzene was much slower than predicted from its reduction potential. The results obtained have significant implications to the likely effectiveness of naturally occurring contaminant degradation processes involving Fe(II) and Fe(III) oxyhydroxides in groundwater environments containing high concentrations of silicate, or other species which compete with Fe(II) for sorption sites.

  2. Activation of MEK 1/2 and p42/44 MAPK by Angiotensin II in Hepatocyte Nucleus and their Potentiation by Ethanol

    Science.gov (United States)

    Aroor, Annayya R.; Lee, Youn Ju; Shukla, Shivendra D.

    2009-01-01

    Hepato-subcellular effect of Ang II and ethanol on the p42/44 MAP Kinase and MEK1/2 were investigated in the nucleus of rat hepatocytes. Hepatocytes were treated with ethanol (100 mM) for 24 hr and stimulated with angiotensin II (Ang II, 100 nM, 5 min). The levels of p42/44 MAPK and MEK1/2 were monitored in the nuclear fraction using antibodies. Ang II itself caused significant accumulation of phospho-p42/44 MAPK in the nucleus without any significant translocation of p42/44 MAPK protein there by suggesting activation of p42/44 MAPK in the nucleus. Ang II caused marked accumulation of phospho-MEK 1/2 in the nucleus without any significant accumulation of MEK1/2 protein. Ratio of phospho-MEK 1/2 to MEK 1/2 protein in the nucleus after Ang II treatment was 2.4 times greater than control suggesting phosphorylation of MEK 1/2 inside the nucleus. Ethanol had no effect on the protein level or the activation of p42/44 MAPK in the nucleus. Ethanol treatment potentiated nuclear activation of p42/44 MPAK by Ang II but not translocation of p42/44 MAPK protein. This was accompanied by potentiation of Ang II stimulated accumulation of phospho-MEK 1/2 in the nucleus by ethanol. MEK 1/2 inhibitor, U-0126 inhibited Ang II response or its potentiation by ethanol. These results suggest that Ang II mediated accumulation of phospho-p42/44 MAPK in the hepatocyte nucleus involves MEK 1/2 dependent activation and this effect is potentiated by ethanol. PMID:19560630

  3. Permutation invariant polynomial neural network approach to fitting potential energy surfaces. II. Four-atom systems

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jun; Jiang, Bin; Guo, Hua, E-mail: hguo@unm.edu [Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131 (United States)

    2013-11-28

    A rigorous, general, and simple method to fit global and permutation invariant potential energy surfaces (PESs) using neural networks (NNs) is discussed. This so-called permutation invariant polynomial neural network (PIP-NN) method imposes permutation symmetry by using in its input a set of symmetry functions based on PIPs. For systems with more than three atoms, it is shown that the number of symmetry functions in the input vector needs to be larger than the number of internal coordinates in order to include both the primary and secondary invariant polynomials. This PIP-NN method is successfully demonstrated in three atom-triatomic reactive systems, resulting in full-dimensional global PESs with average errors on the order of meV. These PESs are used in full-dimensional quantum dynamical calculations.

  4. Self-energy operator for an electron in an external Coulomb potential. II

    International Nuclear Information System (INIS)

    Hostler, L.

    1988-01-01

    Relativistic Coulomb Sturmian matrix elements of the operator Oequivalentln(1-rho)/rho, rho = -[πx(1+iσ)xπ]/m 2 , in terms of which the self-energy operator for an electron in an external Coulomb potential has been expressed, are studied. The operator O is dealt with on a term by term basis in a Sturmian expansion. Each term of the Sturmian expansion is separated into a part whose matrix elements are analytic functions of Zα, plus a remainder evaluated in closed form by use of the Cauchy residue theorem. All ignorance about the matrix element of the general term in the Sturmian expansion of O is thereby placed entirely in the analytic part, for which an explicit integral representation is derived

  5. Tests of potential functional barriers for laminated multilayer food packages. Part II: Medium molecular weight permeants.

    Science.gov (United States)

    Simal-Gándara, J; Sarria-Vidal, M; Rijk, R

    2000-09-01

    Experiments were performed to characterize the kinetics of the permeation of different medium molecular weight model permeants: bisphenol A, warfarin and anthracene, from liquid paraffin, through a surrogate potential functional barrier (25 microns-thick orientated polypropylene--OPP) into the food simulants olive oil and 3% (w/v) acetic acid. The characterization of permeation kinetics generally observed the permeation models previously reported to explain the experimental permeation results obtained for a low molecular weight group of model permeants. In general, the model permeants exhibited behaviour consistent with their relative molecular weights with respect to (a) the time taken to attain steady-state permeation into the food simulant in which they were more soluble, (b) their subsequent steady-state permeation rates, and (c) their partition between liquid paraffin and the OPP membrane.

  6. A finite-element visualization of quantum reactive scattering. II. Nonadiabaticity on coupled potential energy surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Warehime, Mick [Chemical Physics Program, University of Maryland, College Park, Maryland 20742-2021 (United States); Kłos, Jacek; Alexander, Millard H., E-mail: mha@umd.edu [Department of Chemistry and Biochemistry and Institute of Physical Science and Technology, University of Maryland, College Park, Maryland 20742-2021 (United States)

    2015-01-21

    This is the second in a series of papers detailing a MATLAB based implementation of the finite element method applied to collinear triatomic reactions. Here, we extend our previous work to reactions on coupled potential energy surfaces. The divergence of the probability current density field associated with the two electronically adiabatic states allows us to visualize in a novel way where and how nonadiabaticity occurs. A two-dimensional investigation gives additional insight into nonadiabaticity beyond standard one-dimensional models. We study the F({sup 2}P) + HCl and F({sup 2}P) + H{sub 2} reactions as model applications. Our publicly available code (http://www2.chem.umd.edu/groups/alexander/FEM) is general and easy to use.

  7. Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

    Directory of Open Access Journals (Sweden)

    Samira Alliouachene

    2015-12-01

    Full Text Available In contrast to the class I phosphoinositide 3-kinases (PI3Ks, the organismal roles of the kinase activity of the class II PI3Ks are less clear. Here, we report that class II PI3K-C2β kinase-dead mice are viable and healthy but display an unanticipated enhanced insulin sensitivity and glucose tolerance, as well as protection against high-fat-diet-induced liver steatosis. Despite having a broad tissue distribution, systemic PI3K-C2β inhibition selectively enhances insulin signaling only in metabolic tissues. In a primary hepatocyte model, basal PI3P lipid levels are reduced by 60% upon PI3K-C2β inhibition. This results in an expansion of the very early APPL1-positive endosomal compartment and altered insulin receptor trafficking, correlating with an amplification of insulin-induced, class I PI3K-dependent Akt signaling, without impacting MAPK activity. These data reveal PI3K-C2β as a critical regulator of endosomal trafficking, specifically in insulin signaling, and identify PI3K-C2β as a potential drug target for insulin sensitization.

  8. Assessment of Nano Cellulose from Peach Palm Residue as Potential Food Additive: Part II: Preliminary Studies.

    Science.gov (United States)

    Andrade, Dayanne Regina Mendes; Mendonça, Márcia Helena; Helm, Cristiane Vieira; Magalhães, Washington L E; de Muniz, Graciela Ines Bonzon; Kestur, Satyanarayana G

    2015-09-01

    High consumption of dietary fibers in the diet is related to the reduction of the risk of non-transmitting of chronic diseases, prevention of the constipation etc. Rich diets in dietary fibers promote beneficial effects for the metabolism. Considering the above and recognizing the multifaceted advantages of nano materials, there have been many attempts in recent times to use the nano materials in the food sector including as food additive. However, whenever new product for human and animal consumption is developed, it has to be tested for their effectiveness regarding improvement in the health of consumers, safety aspects and side effects. However, before it is tried with human beings, normally such materials would be assessed through biological tests on a living organism to understand its effect on health condition of the consumer. Accordingly, based on the authors' finding reported in a previous paper, this paper presents body weight, biochemical (glucose, cholesterol and lipid profile in blood, analysis of feces) and histological tests carried out with biomass based cellulose nano fibrils prepared by the authors for its possible use as food additive. Preliminary results of the study with mice have clearly brought out potential of these fibers for the said purpose.

  9. New correlation potential for the local-spin-density functional formalism. II

    International Nuclear Information System (INIS)

    Kolar, M.; Farkas, L.

    1982-01-01

    Using the new parameterization for the correlation potential which seems to be the best that is at present available within the local-spin-density (LSD) functional formalism, the Fermi contact term in light atoms (up to Ni) is calculated. Although the overall improvement of the previous LSD results is obtained, discrepancy between theory and experiment remains rather large. It seems that the local approximation for exchange and correlation fails to predict such quantities as magnetic-moment density near the nucleus. It is also shown that the self-interaction correction does not remedy this failure. Further, the effect of the nonzero nuclear radius is investigated and found to be most important in the lightest atoms (e.g. a factor of 0.664 appears in the case of Li). This fact was omitted in all previous calculations and throws doubt on the reported excellent agreement of the results of many-body perturbation theory with experiment. It was also verified that the contact approximation of the Fermi contact term is really good enough. (author)

  10. Making oxidation potentials predictable: Coordination of additives applied to the electronic fine tuning of an iron(II) complex

    KAUST Repository

    Haslinger, Stefan

    2014-11-03

    This work examines the impact of axially coordinating additives on the electronic structure of a bioinspired octahedral low-spin iron(II) N-heterocyclic carbene (Fe-NHC) complex. Bearing two labile trans-acetonitrile ligands, the Fe-NHC complex, which is also an excellent oxidation catalyst, is prone to axial ligand exchange. Phosphine- and pyridine-based additives are used for substitution of the acetonitrile ligands. On the basis of the resulting defined complexes, predictability of the oxidation potentials is demonstrated, based on a correlation between cyclic voltammetry experiments and density functional theory calculated molecular orbital energies. Fundamental insights into changes of the electronic properties upon axial ligand exchange and the impact on related attributes will finally lead to target-oriented manipulation of the electronic properties and consequently to the effective tuning of the reactivity of bioinspired systems.

  11. Making oxidation potentials predictable: Coordination of additives applied to the electronic fine tuning of an iron(II) complex

    KAUST Repository

    Haslinger, Stefan; Kü ck, Jens W.; Hahn, Eva M.; Cokoja, Mirza; Pö thig, Alexander; Basset, Jean-Marie; Kü hn, Fritz

    2014-01-01

    This work examines the impact of axially coordinating additives on the electronic structure of a bioinspired octahedral low-spin iron(II) N-heterocyclic carbene (Fe-NHC) complex. Bearing two labile trans-acetonitrile ligands, the Fe-NHC complex, which is also an excellent oxidation catalyst, is prone to axial ligand exchange. Phosphine- and pyridine-based additives are used for substitution of the acetonitrile ligands. On the basis of the resulting defined complexes, predictability of the oxidation potentials is demonstrated, based on a correlation between cyclic voltammetry experiments and density functional theory calculated molecular orbital energies. Fundamental insights into changes of the electronic properties upon axial ligand exchange and the impact on related attributes will finally lead to target-oriented manipulation of the electronic properties and consequently to the effective tuning of the reactivity of bioinspired systems.

  12. Guideline appraisal with AGREE II: online survey of the potential influence of AGREE II items on overall assessment of guideline quality and recommendation for use.

    Science.gov (United States)

    Hoffmann-Eßer, Wiebke; Siering, Ulrich; Neugebauer, Edmund A M; Brockhaus, Anne Catharina; McGauran, Natalie; Eikermann, Michaela

    2018-02-27

    The AGREE II instrument is the most commonly used guideline appraisal tool. It includes 23 appraisal criteria (items) organized within six domains. AGREE II also includes two overall assessments (overall guideline quality, recommendation for use). Our aim was to investigate how strongly the 23 AGREE II items influence the two overall assessments. An online survey of authors of publications on guideline appraisals with AGREE II and guideline users from a German scientific network was conducted between 10th February 2015 and 30th March 2015. Participants were asked to rate the influence of the AGREE II items on a Likert scale (0 = no influence to 5 = very strong influence). The frequencies of responses and their dispersion were presented descriptively. Fifty-eight of the 376 persons contacted (15.4%) participated in the survey and the data of the 51 respondents with prior knowledge of AGREE II were analysed. Items 7-12 of Domain 3 (rigour of development) and both items of Domain 6 (editorial independence) had the strongest influence on the two overall assessments. In addition, Items 15-17 (clarity of presentation) had a strong influence on the recommendation for use. Great variations were shown for the other items. The main limitation of the survey is the low response rate. In guideline appraisals using AGREE II, items representing rigour of guideline development and editorial independence seem to have the strongest influence on the two overall assessments. In order to ensure a transparent approach to reaching the overall assessments, we suggest the inclusion of a recommendation in the AGREE II user manual on how to consider item and domain scores. For instance, the manual could include an a-priori weighting of those items and domains that should have the strongest influence on the two overall assessments. The relevance of these assessments within AGREE II could thereby be further specified.

  13. Angiotensin II potentiates prostaglandin stimulation of cyclic AMP levels in intact bovine adrenal medulla cells but not adenylate cyclase in permeabilized cells.

    Science.gov (United States)

    Boarder, M R; Plevin, R; Marriott, D B

    1988-10-25

    The level of cyclic AMP in primary cultures of bovine adrenal medulla cells is elevated by prostaglandin E1. Angiotensin II is commonly reported to act on receptors linked to phosphoinositide metabolism or to inhibition of adenylate cyclase. We have investigated the effect of angiotensin II on prostaglandin E1-stimulated cyclic AMP levels in these primary cultures. Rather than reducing cyclic AMP levels, we have found that angiotensin II powerfully potentiates prostaglandin E1-stimulated cyclic AMP accumulation in intact cells, both in the presence and absence of phosphodiesterase inhibitors. The 50% maximal response was similar to that for stimulation of phosphoinositide breakdown by angiotensin II in these cultures. The potentiation of stimulated cyclic AMP levels was seen, although to a smaller maximum, with the protein kinase C (Ca2+/phospholipid-dependent enzyme) activating phorbol ester tetradecanoyl phorbolacetate and with the synthetic diacylglycerol 1-oleoyl-2-acetylglycerol; pretreatment (24 h) with active phorbol ester, which would be expected to diminish protein kinase C levels, attenuated the angiotensin II potentiation of cyclic AMP. Using digitonin-permeabilized cells we showed that adenylate cyclase activity was stimulated by prostaglandin E1 with the same dose-response relationship as was cyclic AMP accumulation in intact cells, but the permeabilized cells showed no response to angiotensin II. The results are discussed with respect to the hypothesis that the angiotensin II influence on cyclic AMP levels is mediated, in part, by diacylglycerol stimulation of protein kinase C.

  14. New antagonists of LHRH. II. Inhibition and potentiation of LHRH by closely related analogues.

    Science.gov (United States)

    Bajusz, S; Csernus, V J; Janaky, T; Bokser, L; Fekete, M; Schally, A V

    1988-12-01

    Modifications of the previously described LHRH antagonists, [Ac-D-Nal(2)1, D-Phe(4Cl)2, D-Trp3, D-Cit6, D-Ala10]LHRH and the corresponding D-Hci6 analogue, have been made to alter the hydrophobicity of the N-terminal acetyl-tripeptide portion. Substitution of D-Trp3 with the less hydrophobic D-Pal(3) had only marginal effects on the antagonistic activities and receptor binding potencies of the D-Cit/D-Hci6 analogues, but it appeared to further improve the toxicity lowering effect of D-Cit/D-Hci6 substitution. Antagonists containing D-Pal(3)3 and D-Cit/D-Hci6 residues, i.e. [Ac-D-Nal(2)1, D-Phe(4Cl)2, D-Pal(3)3, D-Cit6, D-Ala10]LHRH (SB-75) and [Ac-D-Nal(2)1, D-Phe(4Cl)2, D-Pal(3)3, D-Hci6, D-Ala10]LHRH (SB-88), were completely free of the toxic effects, such as cyanosis and respiratory depression leading to death, which have been observed in rats with the D-Trp3, D-Arg6 antagonist and related antagonists. Replacement of the N-acetyl group with the hydrophilic carbamoyl group caused a slight decrease in antagonistic activities, particularly in vitro. Introduction of urethane type acyl group such as methoxycarbonyl (Moc) or t-butoxycarbonyl (Boc) led to analogues that showed LHRH-potentiating effect. The increase in potency induced by these analogues, e.g. [Moc-D-Nal(2)1, D-Phe(4Cl)2, D-Trp3, D-Cit6, D-Ala10]LHRH and [Boc-D-Phe1, D-Phe(4Cl)2, D-Pal(3)3, D-Cit6, D-Ala10]LHRH, was 170-260% and persisted for more than 2 h when studied in a superfused rat pituitary system.

  15. Keeping pace with ACE: are ACE inhibitors and angiotensin II type 1 receptor antagonists potential doping agents?

    Science.gov (United States)

    Wang, Pei; Fedoruk, Matthew N; Rupert, Jim L

    2008-01-01

    In the decade since the angiotensin-converting enzyme (ACE) gene was first proposed to be a 'human gene for physical performance', there have been numerous studies examining the effects of ACE genotype on physical performance phenotypes such as aerobic capacity, muscle function, trainability, and athletic status. While the results are variable and sometimes inconsistent, and corroborating phenotypic data limited, carriers of the ACE 'insertion' allele (the presence of an alu repeat element in intron 16 of the gene) have been reported to have higher maximum oxygen uptake (VO2max), greater response to training, and increased muscle efficiency when compared with individuals carrying the 'deletion' allele (absence of the alu repeat). Furthermore, the insertion allele has been reported to be over-represented in elite athletes from a variety of populations representing a number of endurance sports. The mechanism by which the ACE insertion genotype could potentiate physical performance is unknown. The presence of the ACE insertion allele has been associated with lower ACE activity (ACEplasma) in number of studies, suggesting that individuals with an innate tendency to have lower ACE levels respond better to training and are at an advantage in endurance sporting events. This could be due to lower levels of angiotensin II (the vasoconstrictor converted to active form by ACE), higher levels of bradykinin (a vasodilator degraded by ACE) or some combination of the two phenotypes. Observations that individuals carrying the ACE insertion allele (and presumably lower ACEplasma) have an enhanced response to training or are over-represented amongst elite athletes raises the intriguing question: would individuals with artificially lowered ACEplasma have similar training or performance potential? As there are a number of drugs (i.e. ACE inhibitors and angiotensin II type 1 receptor antagonists [angiotensin receptor blockers--ARBs]) that have the ability to either reduce ACEplasma

  16. Inverse modeling and uncertainty analysis of potential groundwater recharge to the confined semi-fossil Ohangwena II Aquifer, Namibia

    Science.gov (United States)

    Wallner, Markus; Houben, Georg; Lohe, Christoph; Quinger, Martin; Himmelsbach, Thomas

    2017-12-01

    The identification of potential recharge areas and estimation of recharge rates to the confined semi-fossil Ohangwena II Aquifer (KOH-2) is crucial for its future sustainable use. The KOH-2 is located within the endorheic transboundary Cuvelai-Etosha-Basin (CEB), shared by Angola and Namibia. The main objective was the development of a strategy to tackle the problem of data scarcity, which is a well-known problem in semi-arid regions. In a first step, conceptual geological cross sections were created to illustrate the possible geological setting of the system. Furthermore, groundwater travel times were estimated by simple hydraulic calculations. A two-dimensional numerical groundwater model was set up to analyze flow patterns and potential recharge zones. The model was optimized against local observations of hydraulic heads and groundwater age. The sensitivity of the model against different boundary conditions and internal structures was tested. Parameter uncertainty and recharge rates were estimated. Results indicate that groundwater recharge to the KOH-2 mainly occurs from the Angolan Highlands in the northeastern part of the CEB. The sensitivity of the groundwater model to different internal structures is relatively small in comparison to changing boundary conditions in the form of influent or effluent streams. Uncertainty analysis underlined previous results, indicating groundwater recharge originating from the Angolan Highlands. The estimated recharge rates are less than 1% of mean yearly precipitation, which are reasonable for semi-arid regions.

  17. Method of solving conformal models in D-dimensional space 2: A family of exactly solvable models in D > 2

    International Nuclear Information System (INIS)

    Fradkin, E.S.; Palchik, M.Ya.

    1996-02-01

    We study a family of exactly solvable models of conformally-invariant quantum field theory in D-dimensional space. We demonstrate the existence of D-dimensional analogs of primary and secondary fields. Under the action of energy-momentum tensor and conserved currents, the primary fields creates an infinite set of (tensor) secondary fields of different generations. The commutators of secondary fields with zero components of current and energy-momentum tensor include anomalous operator terms. We show that the Hilbert space of conformal theory has a special sector which structure is solely defined by the Ward identities independently on the choice of dynamical model. The states of this sector are constructed from secondary fields. Definite self-consistent conditions on the states of the latter sector fix the choice of the field model uniquely. In particular, Lagrangian models do belong to this class of models. The above self-consistent conditions are formulated as follows. Special superpositions Q s , s = 1,2,... of secondary fields are constructed. Each superposition is determined by the requirement that the form of its commutators with energy-momentum tensor and current (i.e. transformation properties) should be identical to that of a primary field. Each equation Q s (x) = 0 is consistent, and defines an exactly solvable model for D ≥ 3. The structure of these models are analogous to that of well-known two dimensional conformal models. The states Q s (x) modul 0> are analogous to the null-vectors of two dimensional theory. In each of these models one can obtain a closed set of differential equations for all the higher Green functions, as well as algebraic equations relating the scale dimension of fundamental field to the D-dimensional analog of a central charge. As an example, we present a detailed discussion of a pair of exactly solvable models in even-dimensional space D ≥ 4. (author). 28 refs

  18. Synthesis of Two Potentially Heptadentate (N4O3 Schiff-base Ligands Derived from Condensation of Tris(3-aminopropyl-amine and Salicylaldehyde or 4-Hydroxysalicylaldehyde. Nickel(II and Copper(II Complexes of the Former Ligand

    Directory of Open Access Journals (Sweden)

    R. V. Parish

    2002-02-01

    Full Text Available Two potentially heptadentate (N4O3 tripodal Schiff-base ligands: tris(3-(salicylideneiminopropylamine (H3L1 and tris(3-(4’-hydroxysalicylideneimino-propylamine (H3L2 have been prepared and characterized by various spectroscopic methods (IR, FAB-MS, NMR. They are derived from the condensation reactions of tris(3-aminopropylamine (tpt, with 3 equivalents of either salicylaldehyde or the ringsubstituted salicylaldehyde, 4-hydroxysalicylaldehyde. The nickel(II and copper(II complexes of H3L1 were obtained from the its reactions Ni(II and Cu(II salts in absolute methanol. These complexes were studied by IR and FAB-Mass spectrometry.

  19. Infinite number of solvable generalizations of XY-chain, with cluster state, and with central charge c = m/2

    Science.gov (United States)

    Minami, Kazuhiko

    2017-12-01

    An infinite number of spin chains are solved and it is derived that the ground-state phase transitions belong to the universality classes with central charge c = m / 2, where m is an integer. The models are diagonalized by automatically obtained transformations, many of which are different from the Jordan-Wigner transformation. The free energies, correlation functions, string order parameters, exponents, central charges, and the phase diagram are obtained. Most of the examples consist of the stabilizers of the cluster state. A unified structure of the one-dimensional XY and cluster-type spin chains is revealed, and other series of solvable models can be obtained through this formula.

  20. Exact Solutions of a High-Order Nonlinear Wave Equation of Korteweg-de Vries Type under Newly Solvable Conditions

    Directory of Open Access Journals (Sweden)

    Weiguo Rui

    2014-01-01

    Full Text Available By using the integral bifurcation method together with factoring technique, we study a water wave model, a high-order nonlinear wave equation of KdV type under some newly solvable conditions. Based on our previous research works, some exact traveling wave solutions such as broken-soliton solutions, periodic wave solutions of blow-up type, smooth solitary wave solutions, and nonsmooth peakon solutions within more extensive parameter ranges are obtained. In particular, a series of smooth solitary wave solutions and nonsmooth peakon solutions are obtained. In order to show the properties of these exact solutions visually, we plot the graphs of some representative traveling wave solutions.

  1. New Potentials for Old: The Darboux Transformation in Quantum Mechanics

    Science.gov (United States)

    Williams, Brian Wesley; Celius, Tevye C.

    2008-01-01

    The Darboux transformation in quantum mechanics is reviewed at a basic level. Examples of how this transformation leads to exactly solvable potentials related to the "particle in a box" and the harmonic oscillator are shown in detail. The connection between the Darboux transformation and some modern operator based approaches to quantum mechanics…

  2. Expression of EMAP-II in the rat dental follicle and its potential role in tooth eruption

    Science.gov (United States)

    Liu, Dawen; Wise, Gary E.

    2008-01-01

    Endothelial monocyte-activating polypeptide II (EMAP-II) is an inflammatory cytokine with chemotactic activity. Because the dental follicle (DF) recruits mononuclear cells (osteoclast precursors) to promote the osteoclastogenesis needed for tooth eruption, it was the aim of this study to determine if EMAP-II may contribute to this recruitment. Using a DNA microarray, EMAP-II was found to be highly expressed in vivo in the DFs of day 1 to day 11 postnatal rats, with its expression elevated at days 1 and 3. Using a siRNA to knock down EMAP-II expression also resulted in a reduction in expression of CSF-1 and MCP-1 in the DF cells. Addition of EMAP-II protein to the DF cells partially restored the expression of CSF-1 and MCP-1. In chemotaxis assays using either conditioned medium of the DF cells with anti-EMAP-II antibody added or conditioned medium of DF cells with EMAP-II knocked down by siRNA, migration indexes of bone marrow mononuclear cells were significantly reduced. These results suggest that EMAP-II is another chemotactic molecule in the dental follicle involved in recruitment of mononuclear cells, and that EMAP-II may exert its chemotactic function directly by recruiting mononuclear cells and indirectly by enhancing the expression of other chemotactic molecules (CSF-1 and MCP-1). PMID:18705801

  3. Potential Role of Nitrite for Abiotic Fe(II) Oxidation and Cell Encrustation during Nitrate Reduction by Denitrifying Bacteria

    Science.gov (United States)

    Klueglein, Nicole; Zeitvogel, Fabian; Stierhof, York-Dieter; Floetenmeyer, Matthias; Konhauser, Kurt O.; Obst, Martin

    2014-01-01

    Microorganisms have been observed to oxidize Fe(II) at neutral pH under anoxic and microoxic conditions. While most of the mixotrophic nitrate-reducing Fe(II)-oxidizing bacteria become encrusted with Fe(III)-rich minerals, photoautotrophic and microaerophilic Fe(II) oxidizers avoid cell encrustation. The Fe(II) oxidation mechanisms and the reasons for encrustation remain largely unresolved. Here we used cultivation-based methods and electron microscopy to compare two previously described nitrate-reducing Fe(II) oxidizers ( Acidovorax sp. strain BoFeN1 and Pseudogulbenkiania sp. strain 2002) and two heterotrophic nitrate reducers (Paracoccus denitrificans ATCC 19367 and P. denitrificans Pd 1222). All four strains oxidized ∼8 mM Fe(II) within 5 days in the presence of 5 mM acetate and accumulated nitrite (maximum concentrations of 0.8 to 1.0 mM) in the culture media. Iron(III) minerals, mainly goethite, formed and precipitated extracellularly in close proximity to the cell surface. Interestingly, mineral formation was also observed within the periplasm and cytoplasm; intracellular mineralization is expected to be physiologically disadvantageous, yet acetate consumption continued to be observed even at an advanced stage of Fe(II) oxidation. Extracellular polymeric substances (EPS) were detected by lectin staining with fluorescence microscopy, particularly in the presence of Fe(II), suggesting that EPS production is a response to Fe(II) toxicity or a strategy to decrease encrustation. Based on the data presented here, we propose a nitrite-driven, indirect mechanism of cell encrustation whereby nitrite forms during heterotrophic denitrification and abiotically oxidizes Fe(II). This work adds to the known assemblage of Fe(II)-oxidizing bacteria in nature and complicates our ability to delineate microbial Fe(II) oxidation in ancient microbes preserved as fossils in the geological record. PMID:24271182

  4. Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia

    Science.gov (United States)

    Yoshida, Tadashi; Tabony, A. Michael; Galvez, Sarah; Mitch, William E.; Higashi, Yusuke; Sukhanov, Sergiy; Delafontaine, Patrice

    2013-01-01

    Cachexia is a serious complication of many chronic diseases, such as congestive heart failure (CHF) and chronic kidney disease (CKD). Many factors are involved in the development of cachexia, and there is increasing evidence that angiotensin II (Ang II), the main effector molecule of the renin-angiotensin system (RAS), plays an important role in this process. Patients with advanced CHF or CKD often have increased Ang II levels and cachexia, and angiotensin-converting enzyme (ACE) inhibitor treatment improves weight loss. In rodent models, an increase in systemic Ang II leads to weight loss through increased protein breakdown, reduced protein synthesis in skeletal muscle and decreased appetite. Ang II activates the ubiquitin-proteasome system via generation of reactive oxygen species and via inhibition of the insulin-like growth factor-1 signaling pathway. Furthermore, Ang II inhibits 5′ AMP-activated protein kinase (AMPK) activity and disrupts normal energy balance. Ang II also increases cytokines and circulating hormones such as tumor necrosis factor-α, interleukin-6, serum amyloid-A, glucocorticoids and myostatin, which regulate muscle protein synthesis and degradation. Ang II acts on hypothalamic neurons to regulate orexigenic/anorexigenic neuropeptides, such as neuropeptide-Y, orexin and corticotropin-releasing hormone, leading to reduced appetite. Also, Ang II may regulate skeletal muscle regenerative processes. Several clinical studies have indicated that blockade of Ang II signaling via ACE inhibitors or Ang II type 1 receptor blockers prevents weight loss and improves muscle strength. Thus the RAS is a promising target for the treatment of muscle atrophy in patients with CHF and CKD. PMID:23769949

  5. TECHNICAL REPORT ON TECHNOLOGICALLY ENHANCED NATURALLY OCCURRING RADIOACTIVE MATERIALS FROM URANIUM MINING, VOLUME II: INVESTIGATION OF POTENTIAL HEALTH, GEOGRAPHIC, AND ENVIRONMENTAL ISSUES OF ABANDONED URANIUM MINES

    Science.gov (United States)

    Volume II investigates the potential radiogenic risks from abandoned uranium mines and evaluates which may pose the greatest hazards to members of the public and to the environment. The intent of this report is to identify who may be most likely to be exposed to wastes at small a...

  6. A New Result Concerning the Solvability of a Class of General Systems of Variational Equations with Nonmonotone Operators: Applications to Dirichlet and Neumann Nonlinear Problems

    Directory of Open Access Journals (Sweden)

    Luisa Toscano

    2016-01-01

    Full Text Available A new result of solvability for a wide class of systems of variational equations depending on parameters and governed by nonmonotone operators is found in a Banach real and reflexive space with applications to Dirichlet and Neumann problems related to nonlinear elliptic systems.

  7. Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: a new potential treatment of osteoarthritis.

    Science.gov (United States)

    Bagger, Yu Z; Tankó, László B; Alexandersen, Peter; Karsdal, Morten A; Olson, Melvin; Mindeholm, Linda; Azria, Moïse; Christiansen, Claus

    2005-09-01

    To assess the efficacy of 3 months of oral salmon calcitonin (sCT) on cartilage degradation as estimated by the changes in the urinary excretion of C-terminal telopeptide of collagen type II (CTX-II), and to investigate whether the response of oral sCT to urinary CTX-II depends on the baseline level of cartilage turnover. This was a randomized, double blind, placebo-controlled clinical setting including 152 Danish postmenopausal women aged 55-85. The subjects received treatment with the different doses of sCT (0.15, 0.4, 1.0, or 2.5 mg) combined with Eligen technology-based carrier molecule (200 mg), or placebo for 3 months. The efficacy parameter was the changes in the 24-h excretion of urinary CTX-I/II corrected for creatinine excretion at month 3. sCT induced a significant dose-dependent decrease in 24-h urinary CTX-II excretion. Similar dose-dependent responses were found in 24-h urinary CTX-I. When stratifying the study population into tertiles of baseline urinary CTX-II, the present osteoarthritic symptoms and definite cases of osteoarthritis (OA) were significantly more frequent in women in the highest tertile of CTX-II (mean 391 +/- 18 ng/mmol). Women who received 1.0 mg of sCT and had the highest cartilage turnover presented the greatest decrease in urinary CTX-II after 3 months of treatment. In addition to its pronounced effect on bone resorption, this novel oral sCT formulation may also reduce cartilage degradation and thereby provide therapeutic benefit in terms of chondroprotection. Women with high cartilage turnover are more likely to benefit from oral sCT treatment.

  8. Structural instability of sheath potential distribution and its possible implications for the L/H transition in tokamak plasmas

    International Nuclear Information System (INIS)

    Yoshida, Zensho; Yamada, Hiroshi.

    1988-07-01

    The Bohm equation of electrostatic potential distributions in one-dimensional plasmas has been studied for various Mach numbers and plasma potentials. Solvability and structural stability have been discussed using the Sagdeev potential. Implications of the structural stability for the L/H transitions in tokamak plasmas has been also discussed. (author)

  9. Fluctuation-dissipation relation and stationary distribution of an exactly solvable many-particle model for active biomatter far from equilibrium.

    Science.gov (United States)

    Netz, Roland R

    2018-05-14

    An exactly solvable, Hamiltonian-based model of many massive particles that are coupled by harmonic potentials and driven by stochastic non-equilibrium forces is introduced. The stationary distribution and the fluctuation-dissipation relation are derived in closed form for the general non-equilibrium case. Deviations from equilibrium are on one hand characterized by the difference of the obtained stationary distribution from the Boltzmann distribution; this is possible because the model derives from a particle Hamiltonian. On the other hand, the difference between the obtained non-equilibrium fluctuation-dissipation relation and the standard equilibrium fluctuation-dissipation theorem allows us to quantify non-equilibrium in an alternative fashion. Both indicators of non-equilibrium behavior, i.e., deviations from the Boltzmann distribution and deviations from the equilibrium fluctuation-dissipation theorem, can be expressed in terms of a single non-equilibrium parameter α that involves the ratio of friction coefficients and random force strengths. The concept of a non-equilibrium effective temperature, which can be defined by the relation between fluctuations and the dissipation, is by comparison with the exactly derived stationary distribution shown not to hold, even if the effective temperature is made frequency dependent. The analysis is not confined to close-to-equilibrium situations but rather is exact and thus holds for arbitrarily large deviations from equilibrium. Also, the suggested harmonic model can be obtained from non-linear mechanical network systems by an expansion in terms of suitably chosen deviatory coordinates; the obtained results should thus be quite general. This is demonstrated by comparison of the derived non-equilibrium fluctuation dissipation relation with experimental data on actin networks that are driven out of equilibrium by energy-consuming protein motors. The comparison is excellent and allows us to extract the non

  10. Fluctuation-dissipation relation and stationary distribution of an exactly solvable many-particle model for active biomatter far from equilibrium

    Science.gov (United States)

    Netz, Roland R.

    2018-05-01

    An exactly solvable, Hamiltonian-based model of many massive particles that are coupled by harmonic potentials and driven by stochastic non-equilibrium forces is introduced. The stationary distribution and the fluctuation-dissipation relation are derived in closed form for the general non-equilibrium case. Deviations from equilibrium are on one hand characterized by the difference of the obtained stationary distribution from the Boltzmann distribution; this is possible because the model derives from a particle Hamiltonian. On the other hand, the difference between the obtained non-equilibrium fluctuation-dissipation relation and the standard equilibrium fluctuation-dissipation theorem allows us to quantify non-equilibrium in an alternative fashion. Both indicators of non-equilibrium behavior, i.e., deviations from the Boltzmann distribution and deviations from the equilibrium fluctuation-dissipation theorem, can be expressed in terms of a single non-equilibrium parameter α that involves the ratio of friction coefficients and random force strengths. The concept of a non-equilibrium effective temperature, which can be defined by the relation between fluctuations and the dissipation, is by comparison with the exactly derived stationary distribution shown not to hold, even if the effective temperature is made frequency dependent. The analysis is not confined to close-to-equilibrium situations but rather is exact and thus holds for arbitrarily large deviations from equilibrium. Also, the suggested harmonic model can be obtained from non-linear mechanical network systems by an expansion in terms of suitably chosen deviatory coordinates; the obtained results should thus be quite general. This is demonstrated by comparison of the derived non-equilibrium fluctuation dissipation relation with experimental data on actin networks that are driven out of equilibrium by energy-consuming protein motors. The comparison is excellent and allows us to extract the non

  11. Energies of the ground state and first excited 0 sup + state in an exactly solvable pairing model

    CERN Document Server

    Dinh Dang, N

    2003-01-01

    Several approximations are tested by calculating the ground-state energy and the energy of the first excited 0 sup + state using an exactly solvable model with two symmetric levels interacting via a pairing force. They are the BCS approximation (BCS), Lipkin-Nogami (LN) method, random-phase approximation (RPA), quasiparticle RPA (QRPA), the renormalized RPA (RRPA), and renormalized QRPA (RQRPA). It is shown that, in the strong-coupling regime, the QRPA which neglects the scattering term of the model Hamiltonian offers the best fit to the exact solutions. A recipe is proposed using the RRPA and RQRPA in combination with the pairing gap given by the LN method. Applying this recipe, it is shown that the superfluid-normal phase transition is avoided, and a reasonably good description for both of the ground-state energy and the energy of the first excited 0 sup + state is achieved. (orig.)

  12. Infinite number of solvable generalizations of XY-chain, with cluster state, and with central charge c=m/2

    Directory of Open Access Journals (Sweden)

    Kazuhiko Minami

    2017-12-01

    Full Text Available An infinite number of spin chains are solved and it is derived that the ground-state phase transitions belong to the universality classes with central charge c=m/2, where m is an integer. The models are diagonalized by automatically obtained transformations, many of which are different from the Jordan–Wigner transformation. The free energies, correlation functions, string order parameters, exponents, central charges, and the phase diagram are obtained. Most of the examples consist of the stabilizers of the cluster state. A unified structure of the one-dimensional XY and cluster-type spin chains is revealed, and other series of solvable models can be obtained through this formula.

  13. The potential mechanism of Bursal-derived BPP-II on the antibody production and avian pre-B cell.

    Science.gov (United States)

    Feng, Xiuli; Cao, Ruibing; Zhou, Bin; Liu, Qingtao; Liu, Ke; Liu, Xiaodong; Zhang, Yuanpeng; Gu, Jinyan; Miao, Denian; Chen, Puyan

    2013-03-01

    The bursa of Fabricius is critical for the normal development of the B lymphocytes responsible for antibody production. However, the mechanism of the bursal-derived bioactive factor on B cell development is little reported. In this paper, chicks were immunized with BPP-II and AIV vaccine or AIV antigen, and antibody and IL-4 production were detected. The results showed that BPP-II played strongly inducing roles on the humoral immune responses. To investigate the gene expression at transcriptional level, avian pre-B lymphocyte DT40 cells were treated with BPP-II, and were analyzed with the gene microarray. The results proved that BPP-II treatment regulated 11 pathways, in which homologous recombination is a vital mechanism which is involved in antibody Ig gene conversion and diversification during B cell development. These results suggested Bursal-derived biological active factor BPP-II might be involved in the antibody production processes and B cell development, which is vital to the humoral central immune organ, the bursa of Fabricius. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. The study of new complex compounds of Ni (II) and Co (II) with N- hydroxy-succinimide and their potential applications as sensors

    Science.gov (United States)

    Sibiescu, Doina; Tutulea, Mihaela-Dana; Mîţă, Carmen; Stan, Corneliu; Roţca, Ioan; Vizitiu, Mihaela

    2010-11-01

    In this paper, the study of obtaining new coordination compounds of Ni (II) and Co(II) using as ligand, N-hydroxy-succinimide, was presented. Also, the stability constants of these compounds in aqueous medium were determined. The obtaining conditions and the stability of the new compounds were accomplished in aqueous solutions using characteristic methods for coordination compounds: pH-metry, conductometry and UV-VIS absorption spectroscopy. The combination ratios and the stability constants were determined with methods characteristic for studies in solutions. From experimental data resulted that the combination ratio of central metallic atoms with the ligand N-hydroxy-succinimide was: 1:1 and respectively 1:2. In the experiments were used salts of NiCl2.6H2O and CoCl2.6H2O. The optimal domain of pH stability of the studied compounds is limited between 5.74 - 5.86 for Co- N-hydroxy-succinimide (for molar ratio 1:1 and 1:2) and respectively 5.69 - 5.87 for Ni-N-hydroxysuccinimide( for molar ratio 1:1 and 1:2, too). It is important to mention that these compounds were used with very good results in determination of wastewaters from textile, metallurgical, chemical and food industry. Complexion reactions with this ligand are very sensitive for the cations in this paper mentioned. Therefore it is used most often with success in analytical chemistry and also it is posibil to use as sensors. The new complex compounds has electronics transitions at λ = 517 nm for both complexes Co-N-hydroxy-succinimide at molar ratio 1:1 and 1:2 and also at the same λ = 397nm for Ni-N-hydroxysuccinimide at molar ratio 1:1 and 1:2. These complexes compounds was separated and recrystallized from aqueous solution. From the spectrophotometric data it was determined the type and the nature of the electronics transitions by Dq parameters.

  15. Isolation: analysis and properties of three bradykinin-potentiating peptides (BPP-II, BPP-III, and BPP-V) from Bothrops neuwiedi venom.

    Science.gov (United States)

    Ferreira, L A; Galle, A; Raida, M; Schrader, M; Lebrun, I; Habermehl, G

    1998-04-01

    In the course of systematic investigations on low-molecular-weight compounds from the venom of Crotalidae and Viperidae, we have isolated and characterized at least three bradykinin-potentiating peptides (BPP-II, BPP-III, and BPP-V) from Bothrops neuwiedi venom by gel filtration on Sephadex G-25 M, Sephadex G-10 followed by HPLC. The peptides showed bradykinin-potentiating action on isolated guinea-pig ileum, for which the BPP-V was more active than of BPP-II, and BPP-III, rat arterial blood pressure, and a relevant angiotensin-converting enzyme (ACE) competitive inhibiting activity. The kinetic studies showed a Ki of the order of 9.7 x 10(-3) microM to BPP-II, 7 x 10(-3) microM to BPP-III, and 3.3 x 10(-3) microM to BPP-V. The amino acid sequence of the BPP-III has been determined to be pGlu-Gly-Gly-Trp-Pro-Arg-Pro-Gly-Pro-Glu-Ile-Pro-Pro, and the amino acid compositions of the BPP-II and BPP-V by amino acid analysis were 2Glu-2Gly-1Arg-4Pro-1Ile and 2Glu-2Gly-1Ser-3Pro-2Val-1Ile, with molecular weight of 1372, 1046, and 1078, respectively.

  16. Layer potentials and boundary-value problems for second order elliptic operators with data in Besov spaces

    CERN Document Server

    Barton, Ariel

    2016-01-01

    This monograph presents a comprehensive treatment of second order divergence form elliptic operators with bounded measurable t-independent coefficients in spaces of fractional smoothness, in Besov and weighted L^p classes. The authors establish: (1) Mapping properties for the double and single layer potentials, as well as the Newton potential; (2) Extrapolation-type solvability results: the fact that solvability of the Dirichlet or Neumann boundary value problem at any given L^p space automatically assures their solvability in an extended range of Besov spaces; (3) Well-posedness for the non-homogeneous boundary value problems. In particular, the authors prove well-posedness of the non-homogeneous Dirichlet problem with data in Besov spaces for operators with real, not necessarily symmetric, coefficients.

  17. Evaluating Production of Cyclopentyl Tetraethers by Marine Group II Euryarchaeota in the Pearl River Estuary and Coastal South China Sea: Potential Impact on the TEX86 Paleothermometer

    Directory of Open Access Journals (Sweden)

    Jin-Xiang Wang

    2017-10-01

    Full Text Available TEX86 [TetraEther indeX of glycerol dialkyl glycerol tetraethers (GDGTs with 86 carbon atoms] has been widely applied to reconstruct (paleo- sea surface temperature. Marine Group I (MG-I Thaumarchaeota were thought to be the primary source of GDGTs constituting the TEX86 formula; however, recent research has suggested that Marine Group II (MG-II Euryarchaeota may also contribute significantly to the GDGT pool in the ocean. Little is known regarding the potential impact of MG-II Euryarchaeota-derived GDGTs on TEX86 values recorded in marine sediments. In this study, we assessed the relationship between distributions of GDGTs and MG-II Euryarchaeota and evaluated its potential effect on the TEX86 proxy. Lipid and DNA analyses were performed on suspended particulate matter and surface sediments collected along a salinity gradient from the lower Pearl River (river water and its estuary (mixing water to the coastal South China Sea (SCS, seawater. TEX86-derived temperatures from the water column and surface sediments were significantly correlated and both were lower than satellite-based temperatures. The ring index (RI values in these environments were higher than predicted from the calculated TEX86-RI correlation, indicating that the GDGT pool in the water column of the PR estuary and coastal SCS comprises relatively more cyclopentane rings, which thereby altered TEX86 values. Furthermore, the abundance of MG-II Euryarchaeota 16S rRNA gene in the mixing water was two to three orders of magnitude higher than those observed in the river or seawater. Significant linear correlations were observed between the gene abundance ratio of MG-II Euryarchaeota to total archaea and the fractional abundance of GDGTs with cyclopentane rings. Collectively, these results suggest that MG-II Euryarchaeota likely produce a large proportion of GDGTs with 1–4 cyclopentane moieties, which may bias TEX86 values in the water column and sediments. As such, valid

  18. Differential Relationships between WISC-IV and WIAT-II Scales: An Evaluation of Potentially Moderating Child Demographics

    Science.gov (United States)

    Konold, Timothy R.; Canivez, Gary L.

    2010-01-01

    Considerable debate exists regarding the accuracy of intelligence tests with members of different groups. This study investigated differential predictive validity of the "Wechsler Intelligence Scale for Children-Fourth Edition". Participants from the WISC-IV--WIAT-II standardization linking sample (N = 550) ranged in age from 6 through…

  19. Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer : A single-arm phase II study

    NARCIS (Netherlands)

    Vermeij, Renee; Leffers, Ninke; Hoogeboom, Baukje-Nynke; Hamming, Ineke L. E.; Wolf, Rinze; Reyners, Anna K. L.; Molmans, Barbara H. W.; Hollema, Harry; Bart, Joost; Drijfhout, Jan W.; Oostendorp, Jaap; van der Zee, Ate G. J.; Melief, Cornelis J.; van der Burg, Sjoerd H.; Daemen, Toos; Nijman, Hans W.

    2012-01-01

    The purpose of the current phase II single-arm clinical trial was to evaluate whether pretreatment with low-dose cyclophosphamide improves immunogenicity of a p53-synthetic long peptide (SLP) vaccine in patients with recurrent ovarian cancer. Patients with ovarian cancer with elevated serum levels

  20. The hyperbolic step potential: Anti-bound states, SUSY partners and Wigner time delays

    Energy Technology Data Exchange (ETDEWEB)

    Gadella, M. [Departamento de Física Teórica, Atómica y Óptica and IMUVA, Universidad de Valladolid, E-47011 Valladolid (Spain); Kuru, Ş. [Department of Physics, Faculty of Science, Ankara University, 06100 Ankara (Turkey); Negro, J., E-mail: jnegro@fta.uva.es [Departamento de Física Teórica, Atómica y Óptica and IMUVA, Universidad de Valladolid, E-47011 Valladolid (Spain)

    2017-04-15

    We study the scattering produced by a one dimensional hyperbolic step potential, which is exactly solvable and shows an unusual interest because of its asymmetric character. The analytic continuation of the scattering matrix in the momentum representation has a branch cut and an infinite number of simple poles on the negative imaginary axis which are related with the so called anti-bound states. This model does not show resonances. Using the wave functions of the anti-bound states, we obtain supersymmetric (SUSY) partners which are the series of Rosen–Morse II potentials. We have computed the Wigner reflection and transmission time delays for the hyperbolic step and such SUSY partners. Our results show that the more bound states a partner Hamiltonian has the smaller is the time delay. We also have evaluated time delays for the hyperbolic step potential in the classical case and have obtained striking similitudes with the quantum case. - Highlights: • The scattering matrix of hyperbolic step potential is studied. • The scattering matrix has a branch cut and an infinite number of poles. • The poles are associated to anti-bound states. • Susy partners using antibound states are computed. • Wigner time delays for the hyperbolic step and partner potentials are compared.

  1. Phase I to II cross-induction of xenobiotic metabolizing enzymes: A feedforward control mechanism for potential hormetic responses

    International Nuclear Information System (INIS)

    Zhang Qiang; Pi Jingbo; Woods, Courtney G.; Andersen, Melvin E.

    2009-01-01

    Hormetic responses to xenobiotic exposure likely occur as a result of overcompensation by the homeostatic control systems operating in biological organisms. However, the mechanisms underlying overcompensation that leads to hormesis are still unclear. A well-known homeostatic circuit in the cell is the gene induction network comprising phase I, II and III metabolizing enzymes, which are responsible for xenobiotic detoxification, and in many cases, bioactivation. By formulating a differential equation-based computational model, we investigated in this study whether hormesis can arise from the operation of this gene/enzyme network. The model consists of two feedback and one feedforward controls. With the phase I negative feedback control, xenobiotic X activates nuclear receptors to induce cytochrome P450 enzyme, which bioactivates X into a reactive metabolite X'. With the phase II negative feedback control, X' activates transcription factor Nrf2 to induce phase II enzymes such as glutathione S-transferase and glutamate cysteine ligase, etc., which participate in a set of reactions that lead to the metabolism of X' into a less toxic conjugate X''. The feedforward control involves phase I to II cross-induction, in which the parent chemical X can also induce phase II enzymes directly through the nuclear receptor and indirectly through transcriptionally upregulating Nrf2. As a result of the active feedforward control, a steady-state hormetic relationship readily arises between the concentrations of the reactive metabolite X' and the extracellular parent chemical X to which the cell is exposed. The shape of dose-response evolves over time from initially monotonically increasing to J-shaped at the final steady state-a temporal sequence consistent with adaptation-mediated hormesis. The magnitude of the hormetic response is enhanced by increases in the feedforward gain, but attenuated by increases in the bioactivation or phase II feedback loop gains. Our study suggests a

  2. Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses.

    Science.gov (United States)

    Zhang, Qiang; Pi, Jingbo; Woods, Courtney G; Andersen, Melvin E

    2009-06-15

    Hormetic responses to xenobiotic exposure likely occur as a result of overcompensation by the homeostatic control systems operating in biological organisms. However, the mechanisms underlying overcompensation that leads to hormesis are still unclear. A well-known homeostatic circuit in the cell is the gene induction network comprising phase I, II and III metabolizing enzymes, which are responsible for xenobiotic detoxification, and in many cases, bioactivation. By formulating a differential equation-based computational model, we investigated in this study whether hormesis can arise from the operation of this gene/enzyme network. The model consists of two feedback and one feedforward controls. With the phase I negative feedback control, xenobiotic X activates nuclear receptors to induce cytochrome P450 enzyme, which bioactivates X into a reactive metabolite X'. With the phase II negative feedback control, X' activates transcription factor Nrf2 to induce phase II enzymes such as glutathione S-transferase and glutamate cysteine ligase, etc., which participate in a set of reactions that lead to the metabolism of X' into a less toxic conjugate X''. The feedforward control involves phase I to II cross-induction, in which the parent chemical X can also induce phase II enzymes directly through the nuclear receptor and indirectly through transcriptionally upregulating Nrf2. As a result of the active feedforward control, a steady-state hormetic relationship readily arises between the concentrations of the reactive metabolite X' and the extracellular parent chemical X to which the cell is exposed. The shape of dose-response evolves over time from initially monotonically increasing to J-shaped at the final steady state-a temporal sequence consistent with adaptation-mediated hormesis. The magnitude of the hormetic response is enhanced by increases in the feedforward gain, but attenuated by increases in the bioactivation or phase II feedback loop gains. Our study suggests a

  3. Energy spectra of the hyperbolic and second Poeschl-Teller like potentials solved by new exact quantization rule

    International Nuclear Information System (INIS)

    Dong Shihai; Gonzalez-Cisneros, A.

    2008-01-01

    A new exact quantization rule simplifies the calculation of the energy levels for the exactly solvable quantum system. In this work we calculate the energy levels of the Schroedinger equation with the hyperbolic potential by this quantization rule. The corresponding eigenfunction is also derived for completeness. The second Poeschl-Teller like potential case is also carried out

  4. BmajPLA2-II, a basic Lys49-phospholipase A2 homologue from Bothrops marajoensis snake venom with parasiticidal potential.

    Science.gov (United States)

    Grabner, Amy N; Alfonso, Jorge; Kayano, Anderson M; Moreira-Dill, Leandro S; Dos Santos, Ana Paula de A; Caldeira, Cleópatra A S; Sobrinho, Juliana C; Gómez, Ana; Grabner, Fernando P; Cardoso, Fabio F; Zuliani, Juliana Pavan; Fontes, Marcos R M; Pimenta, Daniel C; Gómez, Celeste Vega; Teles, Carolina B G; Soares, Andreimar M; Calderon, Leonardo A

    2017-09-01

    Snake venoms contain various proteins, especially phospholipases A 2 (PLA 2 s), which present potential applications in diverse areas of health and medicine. In this study, a new basic PLA 2 from Bothrops marajoensis with parasiticidal activity was purified and characterized biochemically and biologically. B. marajoensis venom was fractionated through cation exchange followed by reverse phase chromatographies. The isolated toxin, BmajPLA 2 -II, was structurally characterized with MALDI-TOF (Matrix-assisted laser desorption/ionization-time of flight) mass spectrometry, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), followed by two-dimensional electrophoresis, partial amino acid sequencing, an enzymatic activity assay, circular dichroism, and dynamic light scattering assays. These structural characterization tests presented BmajPLA 2 -II as a basic Lys49 PLA 2 homologue, compatible with other basic snake venom PLA 2 s (svPLA 2 ), with a tendency to form aggregations. The in vitro anti-parasitic potential of B. marajoensis venom and of BmajPLA 2 -II was evaluated against Leishmania infantum promastigotes and Trypanosoma cruzi epimastigotes, showing significant activity at a concentration of 100μg/mL. The venom and BmajPLA 2 -II presented IC 50 of 0.14±0.08 and 6.41±0.64μg/mL, respectively, against intraerythrocytic forms of Plasmodium falciparum with CC 50 cytotoxicity values against HepG2 cells of 43.64±7.94 and >150μg/mL, respectively. The biotechnological potential of these substances in relation to leishmaniasis, Chagas disease and malaria should be more deeply investigated. Copyright © 2017. Published by Elsevier B.V.

  5. An approach to one-dimensional elliptic quasi-exactly solvable models

    Indian Academy of Sciences (India)

    potentials in different areas of physics (see above) motivated us to study these potentials and find some new elliptic potentials using generalized master function ... It is straightforward to show that the operator L is a self-adjoint linear operator ... should satisfy with (k − 2) coefficients of Taylor expansion of B as the only un-.

  6. Bender-Dunne Orthogonal Polynomials, Quasi-Exact Solvability and Asymptotic Iteration Method for Rabi Hamiltonian

    International Nuclear Information System (INIS)

    Yahiaoui, S.-A.; Bentaiba, M.

    2011-01-01

    We present a method for obtaining the quasi-exact solutions of the Rabi Hamiltonian in the framework of the asymptotic iteration method (AIM). The energy eigenvalues, the eigenfunctions and the associated Bender-Dunne orthogonal polynomials are deduced. We show (i) that orthogonal polynomials are generated from the upper limit (i.e., truncation limit) of polynomial solutions deduced from AIM, and (ii) prove to have nonpositive norm. (authors)

  7. Bioinformatics Approach Based Research of Profile Protein Carbonic Anhydrase II Analysis as a Potential Candidate Cause Autism for The Variation of Learning Subjects Biotechnology

    Directory of Open Access Journals (Sweden)

    Dian Eka A. F. Ningrum

    2017-03-01

    Full Text Available This study aims to determine the needs of learning variations on Biotechnology courses using bioinformatics approaches. One example of applied use of bioinformatics in biotechnology course is the analysis of protein profiles carbonic anhydrase II as a potential cause of autism candidate. This research is a qualitative descriptive study consisted of two phases. The first phase of the data obtained from observations of learning, student questionnaires, and questionnaires lecturer. Results from the first phase, namely the need for variations learning in Biotechnology course using bioinformatics. Collecting data on the second stage uses three webserver to predict the target protein and scientific articles. Visualization of proteins using PyMOL software. 3 based webserver which is used, the candidate of target proteins associated with autism is carbonic anhydrase II. The survey results revealed that the protein carbonic anhydrase II as a potential candidate for the cause of autism classified metaloenzim are able to bind with heavy metals. The content of heavy metals in autistic patients high that affect metabolism. This prediction of protein candidate cause autism is applied use to solve the problem in society, so that can achieve the learning outcome in biotechnology course.

  8. ApoA-I/A-II-HDL positively associates with apoB-lipoproteins as a potential atherogenic indicator.

    Science.gov (United States)

    Kido, Toshimi; Kondo, Kazuo; Kurata, Hideaki; Fujiwara, Yoko; Urata, Takeyoshi; Itakura, Hiroshige; Yokoyama, Shinji

    2017-11-29

    We recently reported distinct nature of high-density lipoproteins (HDL) subgroup particles with apolipoprotein (apo) A-I but not apoA-II (LpAI) and HDL having both (LpAI:AII) based on the data from 314 Japanese. While plasma HDL level almost exclusively depends on concentration of LpAI having 3 to 4 apoA-I molecules, LpAI:AII appeared with almost constant concentration regardless of plasma HDL levels having stable structure with two apoA-I and one disulfide-dimeric apoA-II molecules (Sci. Rep. 6; 31,532, 2016). The aim of this study is further characterization of LpAI:AII with respect to its role in atherogenesis. Association of LpAI, LpAI:AII and other HDL parameters with apoB-lipoprotein parameters was analyzed among the cohort data above. ApoA-I in LpAI negatively correlated with the apoB-lipoprotein parameters such as apoB, triglyceride, nonHDL-cholesterol, and nonHDL-cholesterol + triglyceride, which are apparently reflected in the relations of the total HDL parameters to apoB-lipoproteins. In contrast, apoA-I in LpAI:AII and apoA-II positively correlated to the apoB-lipoprotein parameters even within their small range of variation. These relationships are independent of sex, but may slightly be influenced by the activity-related CETP mutations. The study suggested that LpAI:AII is an atherogenic indicator rather than antiatherogenic. These sub-fractions of HDL are to be evaluated separately for estimating atherogenic risk of the patients.

  9. Solvable model of quantum phase transitions and the symbolic-manipulation-based study of its multiply degenerate exceptional points and of their unfolding

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2013-01-01

    Roč. 336, SEP (2013), s. 98-111 ISSN 0003-4916 R&D Projects: GA ČR GAP203/11/1433 Institutional support: RVO:61389005 Keywords : Non-Hermitian quantum Hamiltonian * exceptional point * phase transition * exactly solvable model Subject RIV: BE - Theoretical Physics Impact factor: 3.065, year: 2013 http://www.sciencedirect.com/science/article/pii/S0003491613001267

  10. Biophysical Insights into How Spike Threshold Depends on the Rate of Membrane Potential Depolarization in Type I and Type II Neurons.

    Directory of Open Access Journals (Sweden)

    Guo-Sheng Yi

    Full Text Available Dynamic spike threshold plays a critical role in neuronal input-output relations. In many neurons, the threshold potential depends on the rate of membrane potential depolarization (dV/dt preceding a spike. There are two basic classes of neural excitability, i.e., Type I and Type II, according to input-output properties. Although the dynamical and biophysical basis of their spike initiation has been established, the spike threshold dynamic for each cell type has not been well described. Here, we use a biophysical model to investigate how spike threshold depends on dV/dt in two types of neuron. It is observed that Type II spike threshold is more depolarized and more sensitive to dV/dt than Type I. With phase plane analysis, we show that each threshold dynamic arises from the different separatrix and K+ current kinetics. By analyzing subthreshold properties of membrane currents, we find the activation of hyperpolarizing current prior to spike initiation is a major factor that regulates the threshold dynamics. The outward K+ current in Type I neuron does not activate at the perithresholds, which makes its spike threshold insensitive to dV/dt. The Type II K+ current activates prior to spike initiation and there is a large net hyperpolarizing current at the perithresholds, which results in a depolarized threshold as well as a pronounced threshold dynamic. These predictions are further attested in several other functionally equivalent cases of neural excitability. Our study provides a fundamental description about how intrinsic biophysical properties contribute to the threshold dynamics in Type I and Type II neurons, which could decipher their significant functions in neural coding.

  11. A Mixed-Integer Linear Programming Problem which is Efficiently Solvable.

    Science.gov (United States)

    1987-10-01

    ger prongramn rg versions or the problem is not ac’hievable in genieral for sparse inistancves of’ P rolem(r Mi. Th le remrai nder or thris paper is...rClazes c:oIh edge (i,I*) by comlpli urg +- rnirr(z 3, ,x + a,j). A sirnI) le analysis (11 vto Nei [131 indicates why whe Iellinan-Ford algorithm works...ari cl(cck to iceat reguilar rnct’vtuls. For c’xamiic, oi1cc Wwitiil pcroccc’ssicg svlstcici1 rccjcilrcc thicit I iisc wires ice repeated verr 200W

  12. Free radical scavenging activity and neuroprotective potentials of D138, one Cu(II)/Zn(II) Schiff-base complex derived from N,N'-bis(2-hydroxynaphthylmethylidene)-1,3-propanediamine.

    Science.gov (United States)

    Wang, Che; Cai, Zheng-Xu; You, Zhong-Lu; Guo, Hui-Shu; Shang, De-Jing; Wang, Xiao-Ling; Zhang, Liang; Ma, Li-Jie; Tan, Jun; Le, Wei-Dong; Li, Song

    2014-09-01

    There is increasing evidence that free radicals play an important role in neuronal damages induced by diabetes mellitus or cerebral ischemia insults. Antioxidants with free radical scavenging activities have been shown to be beneficial and neuroprotective for these pathological conditions. Here, we report free radical scavenging activity and neuroprotective potential of D138, one copper(II)/zinc(II) Schiff-base complex derived from N,N'-2(2-hydroxynaphthylmethylidene)-1,3-propanediamine. The data from three in vitro assays, 2,2-diphenyl-1-picrylhydrazyl assay, nitro blue tetrazolium assay and hydroxyl radical scavenging assay, indicated that D138 presented a potent free radical scavenging activity. The neuroprotective and antioxidative effects of D138 were further evaluated in vivo using bilateral common carotid artery occlusion (BCCAO) mouse model and streptozotocin (STZ) diabetic mouse model. Our results indicated that treatment of D138 significantly ameliorated the hippocampal neuronal damage and the oxidative stress levels in these animal models. Moreover, D138 also reversed the behavioral deficiencies induced by BCCAO or STZ, as assessed by Y-maze test and fear conditioning test. In conclusion, all these findings support that D138 exerts free radical scavenging and neuroprotective activities and has the potentials to be a potent therapeutic candidate for brain oxidative damage induced by cerebral ischemia or diabetes mellitus.

  13. Scattering of thermal He beams by crossed atomic and molecular beams. II. The He--Ar van der Waals potential

    International Nuclear Information System (INIS)

    Keilb, M.; Slankas, J.T.; Kuppermann, A.

    1979-01-01

    Differential cross sections for He--Ar scattering at room temperature have been measured. The experimental consistency of these measurements with others performed in different laboratories is demonstrated. Despite this consistency, the present van der Waals well depth of 1.78 meV, accurate to 10%, is smaller by 20% to 50% than the experimental values obtained previously. These discrepancies are caused by differences between the assumed mathematical forms or between the assumed dispersion coefficients of the potentials used in the present paper and those of previous studies. Independent investigations have shown that the previous assumptions are inappropriate for providing accurate potentials from fits to experimental differential cross section data for He--Ar. We use two forms free of this inadequacy in the present analysis: a modified version of the Simons--Parr--Finlan--Dunham (SPFD) potential, and a double Morse--van der Waals (M 2 SV) type of parameterization. The resulting He--Ar potentials are shown to be equal to with experimental error, throughout the range of interatomic distances to which the scattering data are sensitive. The SPFD or M 2 SV potentials are combined with a repulsive potential previously determined exclusively from fits to gas phase bulk properties. The resulting potentials, valid over the extended range of interatomic distances r> or approx. =2.4 A, are able to reproduce all these bulk properties quite well, without adversely affecting the quality of the fits to the DCS

  14. Minkowski space structure of the Higgs potential in the two-Higgs-doublet model. II. Minima, symmetries, and topology

    International Nuclear Information System (INIS)

    Ivanov, I. P.

    2008-01-01

    We continue to explore the consequences of the recently discovered Minkowski space structure of the Higgs potential in the two-Higgs-doublet model. Here, we focus on the vacuum properties. The search for extrema of the Higgs potential is reformulated in terms of 3-quadrics in the 3+1-dimensional Minkowski space. We prove that 2HDM cannot have more than two local minima in the orbit space and that a twice-degenerate minimum can arise only via spontaneous violation of a discrete symmetry of the Higgs potential. Investigating topology of the 3-quadrics, we give concise criteria for existence of noncontractible paths in the Higgs orbit space. We also study explicit symmetries of the Higgs potential/Lagrangian and their spontaneous violation from a wider perspective than usual

  15. Heavy ion beam probe investigations of plasma potential in ECRH and NBI in the TJ-II stellarator

    International Nuclear Information System (INIS)

    Melnikov, A.V.; Eliseev, L.; Perfilov, S.V.; Chmyga, A.A.; Dreval, N.; Khrebtov, S.M.; Komarov, A.D.; Kozachok, A.S.; Krupnik, L.; Alonso, A.; Pablos, J.L. de; Cappa, A.; Fernandez, A.; Fuentes, C.; Hidalgo, C.; Liniers, M.; Pedrosa, M.A.

    2005-01-01

    Direct measurements of electric potential and its fluctuations are of a primary importance in magnetic confinement systems. The Heavy Ion Beam Probe (HIBP) diagnostic is used in TJ-2 stellarator to study directly plasma electric potential profiles with spatial (up to 1cm) and temporal (up to 10 ∝s) resolution. The singly charged heavy ions Cs + with energies up to 125 keV are used to probe the plasma column from the edge to the core. Both ECRH and NBI heated plasmas (P ECRH = 200 - 400kW, P NBI = 400kW, E NBI = 28 kV) were studied. The significant improvement in the HIBP beam control system and the acquisition electronics leads us to increase the possibilities of the diagnostic. The most crucial one is the extension of the signal dynamic range, which allows us to have the reliable profiles from the plasma center to the plasma edge both in the high and low field side regions. Low density ECRH (n = 0.5-1.1.10 13 cm -3 ) plasmas in TJ-2 are characterised by core positive plasma potential of order of 500 - 1000 V and positive electric fields up to 50 V/cm. Edge radial electric fields remain positive at low densities and became negative at the threshold density that depends of plasma configuration. NBI plasmas are characterized by negative electric potential in the full plasma column and negative radial electric fields (in the range of 10 - 40 V/cm). The density rise during the NBI phase is accompanied by the decay of core plasma potential. When density is getting the level of n ∼ 2.0.10 13 cm -3 , the potential stops its evolution and remains constant. The evolution of plasma potential near density limit is under investigation. These observations, reported in different magnetic configurations, show the clear link between plasma potential and plasma density. (author)

  16. Potential application of population models in the European ecological risk assessment of chemicals. II. Review of models and their potential to address environmental protection aims.

    Science.gov (United States)

    Galic, Nika; Hommen, Udo; Baveco, J M Hans; van den Brink, Paul J

    2010-07-01

    Whereas current chemical risk assessment (RA) schemes within the European Union (EU) focus mainly on toxicity and bioaccumulation of chemicals in individual organisms, most protection goals aim at preserving populations of nontarget organisms rather than individuals. Ecological models are tools rarely recommended in official technical documents on RA of chemicals, but are widely used by researchers to assess risks to populations, communities and ecosystems. Their great advantage is the relatively straightforward integration of the sensitivity of species to chemicals, the mode of action and fate in the environment of toxicants, life-history traits of the species of concern, and landscape features. To promote the usage of ecological models in regulatory risk assessment, this study tries to establish whether existing, published ecological modeling studies have addressed or have the potential to address the protection aims and requirements of the chemical directives of the EU. We reviewed 148 publications, and evaluated and analyzed them in a database according to defined criteria. Published models were also classified in terms of 5 areas where their application would be most useful for chemical RA. All potential application areas are well represented in the published literature. Most models were developed to estimate population-level responses on the basis of individual effects, followed by recovery process assessment, both in individuals and at the level of metapopulations. We provide case studies for each of the proposed areas of ecological model application. The lack of clarity about protection goals in legislative documents made it impossible to establish a direct link between modeling studies and protection goals. Because most of the models reviewed here were not developed for regulatory risk assessment, there is great potential and a variety of ecological models in the published literature. (c) 2010 SETAC.

  17. Practice makes perfect: familiarity of task determines success in solvable tasks for free-ranging dogs (Canis lupus familiaris).

    Science.gov (United States)

    Bhattacharjee, Debottam; Dasgupta, Sandipan; Biswas, Arpita; Deheria, Jayshree; Gupta, Shreya; Nikhil Dev, N; Udell, Monique; Bhadra, Anindita

    2017-07-01

    Domestic dogs' (Canis lupus familiaris) socio-cognitive faculties have made them highly sensitive to human social cues. While dogs often excel at understanding human communicative gestures, they perform comparatively poorly in problem-solving and physical reasoning tasks. This difference in their behaviour could be due to the lifestyle and intense socialization, where problem solving and physical cognition are less important than social cognition. Free-ranging dogs live in human-dominated environments, not under human supervision and are less socialized. Being scavengers, they often encounter challenges where problem solving is required in order to get access to food. We tested Indian street dogs in familiar and unfamiliar independent solvable tasks and quantified their persistence and dependence on a novel human experimenter, in addition to their success in solving a task. Our results indicate that free-ranging dogs succeeded and persisted more in the familiar task as compared to the unfamiliar one. They showed negligible amount of human dependence in the familiar task, but showed prolonged gazing and considerable begging behaviour to the human experimenter in the context of the unfamiliar task. Cognitive abilities of free-ranging dogs thus play a pivotal role in determining task-associated behaviours based on familiarity. In addition to that, these dogs inherently tend to socialize with and depend on humans, even if they are strangers. Our results also illustrate free-ranging dogs' low competence at physical cognitive tasks.

  18. CRE Solvability, Nonlocal Symmetry and Exact Interaction Solutions of the Fifth-Order Modified Korteweg-de Vries Equation

    Science.gov (United States)

    Cheng, Wen-Guang; Qiu, De-Qin; Yu, Bo

    2017-06-01

    This paper is concerned with the fifth-order modified Korteweg-de Vries (fmKdV) equation. It is proved that the fmKdV equation is consistent Riccati expansion (CRE) solvable. Three special form of soliton-cnoidal wave interaction solutions are discussed analytically and shown graphically. Furthermore, based on the consistent tanh expansion (CTE) method, the nonlocal symmetry related to the consistent tanh expansion (CTE) is investigated, we also give the relationship between this kind of nonlocal symmetry and the residual symmetry which can be obtained with the truncated Painlevé method. We further study the spectral function symmetry and derive the Lax pair of the fmKdV equation. The residual symmetry can be localized to the Lie point symmetry of an enlarged system and the corresponding finite transformation group is computed. Supported by National Natural Science Foundation of China under Grant No. 11505090, and Research Award Foundation for Outstanding Young Scientists of Shandong Province under Grant No. BS2015SF009

  19. Methodological considerations regarding the use of inorganic {sup 197}Hg(II) radiotracer to assess mercury methylation potential rates in lake sediment

    Energy Technology Data Exchange (ETDEWEB)

    Perez Catan, Soledad [Laboratorio de Analisis por Activacion Neutronica, Comision Nacional de Energia Atomica, Centro Atomico Bariloche, 8400 Bariloche (Argentina); Guevara, Sergio Ribeiro [Laboratorio de Analisis por Activacion Neutronica, Comision Nacional de Energia Atomica, Centro Atomico Bariloche, 8400 Bariloche (Argentina)], E-mail: ribeiro@cab.cnea.gov.ar; Marvin-DiPasquale, Mark [US Geological Survey, 345 Middlefield Rd./MS 480, Menlo Park, CA 94025 (United States); Magnavacca, Cecilia [Centro Atomico Ezeiza, Comision Nacional de Energia Atomica, Presbitero Gonzalez y Aragon No. 15, B1802AYA, Ezeiza, Buenos Aires (Argentina); Cohen, Isaac Marcos [Departamento de Ingenieria Quimica, Facultad Regional Buenos Aires, Universidad Tecnologica Nacional, Medrano 951 (C1179AAQ) Buenos Aires (Argentina); Arribere, Maria [Laboratorio de Analisis por Activacion Neutronica, Comision Nacional de Energia Atomica, Centro Atomico Bariloche, 8400 Bariloche (Argentina)

    2007-09-15

    Methodological considerations on the determination of benthic methyl-mercury (CH{sub 3}Hg) production potentials were investigated on lake sediment, using {sup 197}Hg radiotracer. Three methods to arrest bacterial activity were compared: flash freezing, thermal sterilization, and {gamma}-irradiation. Flash freezing showed similar CH{sub 3}Hg recoveries as thermal sterilization, which was both 50% higher than the recoveries obtained with {gamma}-ray irradiation. No additional radiolabel was recovered in kill-control samples after an additional 24 or 65 h of incubation, suggesting that all treatments were effective at arresting Hg(II)-methylating bacterial activity, and that the initial recoveries are likely due to non-methylated {sup 197}Hg(II) carry-over in the organic extraction and/or [{sup 197}Hg]CH{sub 3}Hg produced via abiotic reactions. Two CH{sub 3}Hg extraction methods from sediment were compared: (a) direct extraction into toluene after sediment leaching with CuSO{sub 4} and HCl and (b) the same extraction with an additional back-extraction step to thiosulphate. Similar information was obtained with both methods, but the low efficiency observed and the extra work associated with the back-extraction procedure represent significant disadvantages, even tough the direct extraction involves higher Hg(II) carry over.

  20. Methodological considerations regarding the use of inorganic 197Hg(II) radiotracer to assess mercury methylation potential rates in lake sediment

    International Nuclear Information System (INIS)

    Perez Catan, Soledad; Guevara, Sergio Ribeiro; Marvin-DiPasquale, Mark; Magnavacca, Cecilia; Cohen, Isaac Marcos; Arribere, Maria

    2007-01-01

    Methodological considerations on the determination of benthic methyl-mercury (CH 3 Hg) production potentials were investigated on lake sediment, using 197 Hg radiotracer. Three methods to arrest bacterial activity were compared: flash freezing, thermal sterilization, and γ-irradiation. Flash freezing showed similar CH 3 Hg recoveries as thermal sterilization, which was both 50% higher than the recoveries obtained with γ-ray irradiation. No additional radiolabel was recovered in kill-control samples after an additional 24 or 65 h of incubation, suggesting that all treatments were effective at arresting Hg(II)-methylating bacterial activity, and that the initial recoveries are likely due to non-methylated 197 Hg(II) carry-over in the organic extraction and/or [ 197 Hg]CH 3 Hg produced via abiotic reactions. Two CH 3 Hg extraction methods from sediment were compared: (a) direct extraction into toluene after sediment leaching with CuSO 4 and HCl and (b) the same extraction with an additional back-extraction step to thiosulphate. Similar information was obtained with both methods, but the low efficiency observed and the extra work associated with the back-extraction procedure represent significant disadvantages, even tough the direct extraction involves higher Hg(II) carry over

  1. Potential of Ranunculus acris L. for biomonitoring trace element contamination of riverbank soils: photosystem II activity and phenotypic responses for two soil series.

    Science.gov (United States)

    Marchand, Lilian; Lamy, Pierre; Bert, Valerie; Quintela-Sabaris, Celestino; Mench, Michel

    2016-02-01

    Foliar ionome, photosystem II activity, and leaf growth parameters of Ranunculus acris L., a potential biomonitor of trace element (TE) contamination and phytoavailability, were assessed using two riverbank soil series. R. acris was cultivated on two potted soil series obtained by mixing a TE (Cd, Cu, Pb, and Zn)-contaminated technosol with either an uncontaminated sandy riverbank soil (A) or a silty clay one slightly contaminated by TE (B). Trace elements concentrations in the soil-pore water and the leaves, leaf dry weight (DW) yield, total leaf area (TLA), specific leaf area (SLA), and photosystem II activity were measured for both soil series after a 50-day growth period. As soil contamination increased, changes in soluble TE concentrations depended on soil texture. Increase in total soil TE did not affect the leaf DW yield, the TLA, the SLA, and the photosystem II activity of R. acris over the 50-day exposure. The foliar ionome did not reflect the total and soluble TE concentrations in both soil series. Foliar ionome of R. acris was only effective to biomonitor total and soluble soil Na concentrations in both soil series and total and soluble soil Mo concentrations in the soil series B.

  2. A New Quasi-Exactly Solvable Problem and Its Connection with an Anharmonic Oscillator

    International Nuclear Information System (INIS)

    Yang Dabao; Zhang Fulin; Chen Jingling

    2010-01-01

    The two-dimensional hydrogen with a linear potential in a magnetic field is solved by two different methods. Furthermore the connection between the model and an anharmonic oscillator is investigated by methods of KS transformation. (general)

  3. Synthesis, physicochemical characterization, DFT calculation and biological activities of Fe(III) and Co(II)-omeprazole complexes. Potential application in the Helicobacter pylori eradication

    Science.gov (United States)

    Russo, Marcos G.; Vega Hissi, Esteban G.; Rizzi, Alberto C.; Brondino, Carlos D.; Salinas Ibañez, Ángel G.; Vega, Alba E.; Silva, Humberto J.; Mercader, Roberto; Narda, Griselda E.

    2014-03-01

    The reaction between the antiulcer agent omeprazole (OMZ) with Fe(III) and Co(II) ions was studied, observing a high ability to form metal complexes. The isolated microcrystalline solid complexes were characterized by elemental analysis, X-ray powder diffraction (XRPD), Scanning Electron Microscopy (SEM), magnetic measurements, thermal study, FTIR, UV-Visible, Mössbauer, electronic paramagnetic resonance (EPR), and DFT calculations. The metal-ligand ratio for both complexes was 1:2 determined by elemental and thermal analysis. FTIR spectroscopy showed that OMZ acts as a neutral bidentate ligand through the pyridinic nitrogen of the benzimidazole ring and the oxygen atom of the sulfoxide group, forming a five-membered ring chelate. Electronic, Mössbauer, and EPR spectra together with magnetic measurements indicate a distorted octahedral geometry around the metal ions, where the coordination sphere is completed by two water molecules. SEM and XRPD were used to characterize the morphology and the crystal nature of the complexes. The most favorable conformation for the Fe(III)-OMZ and Co(II)-OMZ complexes was obtained by DFT calculations by using B3LYP/6-31G(d)&LanL2DZ//B3LYP/3-21G(d)&LanL2DZ basis set. Studies of solubility along with the antibacterial activity against Helicobacter pylori for OMZ and its Co(II) and Fe(III) complexes are also reported. Free OMZ and both metal complexes showed antibacterial activity against H. pylori. Co(II)-OMZ presented a minimal inhibitory concentration ˜32 times lower than that of OMZ and ˜65 lower than Fe(III)-OMZ, revealing its promising potential use for the treatment of gastric pathologies associated with the Gram negative bacteria. The morphological changes observed in the cell membrane of the bacteria after the incubation with the metal-complexes were also analyzed by SEM microscopy. The antimicrobial activity of the complexes was proved by the viability test.

  4. On the classical theory of ordinary linear differential equations of the second order and the Schroedinger equation for power law potentials

    International Nuclear Information System (INIS)

    Lima, M.L.; Mignaco, J.A.

    1983-01-01

    The power law potentials in the Schroedinger equation solved recently are shown to come from the classical treatment of the singularities of a linear, second order differential equation. This allows to enlarge the class of solvable power law potentials. (Author) [pt

  5. Biofuel production potentials in Europe: sustainable use of cultivated land and pastures. Part II: Land use scenarios

    NARCIS (Netherlands)

    Fischer, G.; Prieler, S.; van Velthuizen, H.; Berndes, G.; Faaij, A.P.C.; Londo, H.M.; de Wit, M.P.

    2009-01-01

    Europe's agricultural land (including Ukraine) comprise of 164 million hectares of cultivated land and 76 million hectares of permanent pasture. A “food first” paradigm was applied in the estimations of land potentially available for the production of biofuel feedstocks, without putting at risk food

  6. Pediatric cancer gone viral. Part II: potential clinical application of oncolytic herpes simplex virus-1 in children

    Directory of Open Access Journals (Sweden)

    Gregory K Friedman

    Full Text Available Oncolytic engineered herpes simplex viruses (HSVs possess many biologic and functional attributes that support their use in clinical trials in children with solid tumors. Tumor cells, in an effort to escape regulatory mechanisms that would impair their growth and progression, have removed many mechanisms that would have protected them from virus infection and eventual virus-mediated destruction. Viruses engineered to exploit this weakness, like mutant HSV, can be safely employed as tumor cell killers, since normal cells retain these antiviral strategies. Many preclinical studies and early phase trials in adults demonstrated that oncolytic HSV can be safely used and are highly effective in killing tumor cells that comprise pediatric malignancies, without generating the toxic side effects of nondiscriminatory chemotherapy or radiation therapy. A variety of engineered viruses have been developed and tested in numerous preclinical models of pediatric cancers and initial trials in patients are underway. In Part II of this review series, we examine the preclinical evidence to support the further advancement of oncolytic HSV in the pediatric population. We discuss clinical advances made to date in this emerging era of oncolytic virotherapy.

  7. Path integral approach for superintegrable potentials on spaces of non-constant curvature. Pt. 1. Darboux spaces D{sub I} and D{sub II}

    Energy Technology Data Exchange (ETDEWEB)

    Grosche, C. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Pogosyan, G.S. [Joint Inst. of Nuclear Research, Moscow (Russian Federation). Bogoliubov Lab. of Theoretical Physics]|[Guadalajara Univ., Jalisco (Mexico). Dept. de Matematicas CUCEI; Sissakian, A.N. [Joint Inst. of Nuclear Research, Moscow (Russian Federation). Bogoliubov Lab. of Theoretical Physics

    2006-07-15

    In this paper the Feynman path integral technique is applied for superintegrable potentials on two-dimensional spaces of non-constant curvature: these spaces are Darboux spaces D{sub I} and D{sub II}, respectively. On D{sub I} there are three and on D{sub II} foru such potentials, respectively. We are able to evaluate the path integral in most of the separating coordinate systems, leading to expressions for the Green functions, the discrete and continuous wave-functions, and the discrete energy-spectra. In some cases, however, the discrete spectrum cannot be stated explicitly, because it is either determined by a transcendental equation involving parabolic cylinder functions (Darboux space I), or by a higher order polynomial equation. The solutions on D{sub I} in particular show that superintegrable systems are not necessarily degenerate. We can also show how the limiting cases of flat space (Constant curvature zero) and the two-dimensional hyperboloid (constant negative curvature) emerge. (Orig.)

  8. Inverse Scattering Problem For The Schrödinger Equation With An Additional Quadratic Potential On The Entire Axis

    Science.gov (United States)

    Guseinov, I. M.; Khanmamedov, A. Kh.; Mamedova, A. F.

    2018-04-01

    We consider the Schrödinger equation with an additional quadratic potential on the entire axis and use the transformation operator method to study the direct and inverse problems of the scattering theory. We obtain the main integral equations of the inverse problem and prove that the basic equations are uniquely solvable.

  9. Graphs and an exactly solvable N-body problem in one dimension

    Energy Technology Data Exchange (ETDEWEB)

    Barucchi, G [Turin Univ. (Italy). Ist. di Fisica Matematica

    1980-08-21

    The one-dimensional N-body classical problem with inversely quadratic pair potential is considered. A method of explicit construction, by means of graphs, of the constants of the motion is given. It is then shown how to obtain, by means of a computer, the position variables of the particles as numerical functions of time.

  10. Solvable single-species aggregation-annihilation model for chain-shaped cluster growth

    International Nuclear Information System (INIS)

    Ke Jianhong; Lin Zhenquan; Zheng Yizhuang; Chen Xiaoshuang; Lu Wei

    2007-01-01

    We propose a single-species aggregation-annihilation model, in which an aggregation reaction between two clusters produces an active cluster and an annihilation reaction produces an inert one. By means of the mean-field rate equation, we respectively investigate the kinetic scaling behaviours of three distinct systems. The results exhibit that: (i) for the general aggregation-annihilation system, the size distribution of active clusters consistently approaches the conventional scaling form; (ii) for the system with the self-degeneration of the cluster's activities, it takes the modified scaling form; and (iii) for the system with the self-closing of active clusters, it does not scale. Moreover, the size distribution of inert clusters with small size takes a power-law form, while that of large inert clusters obeys the scaling law. The results also show that all active clusters will eventually transform into inert ones and the inert clusters of any size can be produced by such an aggregation-annihilation process. This model can be used to mimic the chain-shaped cluster growth and can provide some useful predictions for the kinetic behaviour of the system

  11. Exactly solvable quantum state reduction models with time-dependent coupling

    International Nuclear Information System (INIS)

    Brody, Dorje C; Constantinou, Irene C; Dear, James D C; Hughston, Lane P

    2006-01-01

    A closed-form solution to the energy-based stochastic Schroedinger equation with a time-dependent coupling is obtained. The solution is algebraic in character, and is expressed directly in terms of independent random data. The data consist of (i) a random variable H which has the distribution P(H=E i ) = π i , where π i is the transition probability vertical bar (ψ 0 vertical bar Φ i ) vertical bar 2 from the initial state vertical bar ψ 0 ) to the Lueders state vertical bar Φ i ) with energy E i , and (ii) an independent P-Brownian motion, where P is the physical probability measure associated with the dynamics of the reduction process. When the coupling is time independent, it is known that state reduction occurs asymptotically-that is to say, over an infinite time horizon. In the case of a time-dependent coupling, we show that if the magnitude of the coupling decreases sufficiently rapidly, then the energy variance will be reduced under the dynamics, but the state need not reach an energy eigenstate. This situation corresponds to the case of a 'partial' or 'incomplete' measurement of the energy. We also construct an example of a model where the opposite situation prevails, in which complete state reduction is achieved after the passage of a finite period of time

  12. Solvable Catalyzed Birth-Death-Exchange Competition Model of Three Species

    International Nuclear Information System (INIS)

    Wang Haifeng; Gao Yan; Zhang Heng; Lin Zhenquan

    2009-01-01

    A competition model of three species in exchange-driven aggregation growth is proposed. In the model, three distinct aggregates grow by exchange of monomers and in parallel, birth of species A is catalyzed by species B and death of species A is catalyzed by species C. The rates for both catalysis processes are proportional to kj ν and kj ω respectively, where ν(Ω) is a parameter reflecting the dependence of the catalysis reaction rate of birth (death) on the catalyst aggregate's size. The kinetic evolution behaviors of the three species are investigated by the rate equation approach based on the mean-field theory. The form of the aggregate size distribution of A-species a k (t) is found to be dependent crucially on the two catalysis rate kernel parameters. The results show that (i) in case of μ ≤ 0, the form of a k (t) mainly depends on the competition between self-exchange of species A and species-C-catalyzed death of species A; (ii) in case of ν > 0, the form of a k (t) mainly depends on the competition between species-B-catalyzed birth of species A and species-C-catalyzed death of species A. (interdisciplinary physics and related areas of science and technology)

  13. Entanglement entropy production in gravitational collapse: covariant regularization and solvable models

    Science.gov (United States)

    Bianchi, Eugenio; De Lorenzo, Tommaso; Smerlak, Matteo

    2015-06-01

    We study the dynamics of vacuum entanglement in the process of gravitational collapse and subsequent black hole evaporation. In the first part of the paper, we introduce a covariant regularization of entanglement entropy tailored to curved spacetimes; this regularization allows us to propose precise definitions for the concepts of black hole "exterior entropy" and "radiation entropy." For a Vaidya model of collapse we find results consistent with the standard thermodynamic properties of Hawking radiation. In the second part of the paper, we compute the vacuum entanglement entropy of various spherically-symmetric spacetimes of interest, including the nonsingular black hole model of Bardeen, Hayward, Frolov and Rovelli-Vidotto and the "black hole fireworks" model of Haggard-Rovelli. We discuss specifically the role of event and trapping horizons in connection with the behavior of the radiation entropy at future null infinity. We observe in particular that ( i) in the presence of an event horizon the radiation entropy diverges at the end of the evaporation process, ( ii) in models of nonsingular evaporation (with a trapped region but no event horizon) the generalized second law holds only at early times and is violated in the "purifying" phase, ( iii) at late times the radiation entropy can become negative (i.e. the radiation can be less correlated than the vacuum) before going back to zero leading to an up-down-up behavior for the Page curve of a unitarily evaporating black hole.

  14. Entanglement entropy production in gravitational collapse: covariant regularization and solvable models

    International Nuclear Information System (INIS)

    Bianchi, Eugenio; Lorenzo, Tommaso De; Smerlak, Matteo

    2015-01-01

    We study the dynamics of vacuum entanglement in the process of gravitational collapse and subsequent black hole evaporation. In the first part of the paper, we introduce a covariant regularization of entanglement entropy tailored to curved spacetimes; this regularization allows us to propose precise definitions for the concepts of black hole “exterior entropy” and “radiation entropy.” For a Vaidya model of collapse we find results consistent with the standard thermodynamic properties of Hawking radiation. In the second part of the paper, we compute the vacuum entanglement entropy of various spherically-symmetric spacetimes of interest, including the nonsingular black hole model of Bardeen, Hayward, Frolov and Rovelli-Vidotto and the “black hole fireworks” model of Haggard-Rovelli. We discuss specifically the role of event and trapping horizons in connection with the behavior of the radiation entropy at future null infinity. We observe in particular that (i) in the presence of an event horizon the radiation entropy diverges at the end of the evaporation process, (ii) in models of nonsingular evaporation (with a trapped region but no event horizon) the generalized second law holds only at early times and is violated in the “purifying” phase, (iii) at late times the radiation entropy can become negative (i.e. the radiation can be less correlated than the vacuum) before going back to zero leading to an up-down-up behavior for the Page curve of a unitarily evaporating black hole.

  15. Assessment of the feasibility of studying the potential health effects of the West Valley Solidification Project. Phase II

    International Nuclear Information System (INIS)

    Matanoski, G.M.

    The activities at West Valley involve potential exposure to ionizing radiation. The health effects from radiation are well known and the projected levels of exposure in this situation are so low as to pose no known health hazard in the community. In such a situation it is not reasonable to propose an expensive, comprehensive and physically invasive screening program for the public unless one could justify the benefits. This report describes a feasible population-based surveillance or disease monitoring system which could be implemented in the West Valley area in order to assess the relevance of any changes in incidence of disease which might be attributable to radiation. The proposed plan is both practical and inexpensive. It would anticipate any potential changes in the health status of the population and provide a means to objectively interpret such changes before major concerns develop

  16. Automatic change detection in vision: Adaptation, memory mismatch, or both? II: Oddball and adaptation effects on event-related potentials.

    Science.gov (United States)

    Bodnár, Flóra; File, Domonkos; Sulykos, István; Kecskés-Kovács, Krisztina; Czigler, István

    2017-11-01

    In this study we compared the event-related potentials (ERPs) obtained in two different paradigms: a passive visual oddball paradigm and an adaptation paradigm. The aim of the study was to investigate the relation between the effects of activity decrease following an adaptor (stimulus-specific adaptation) and the effects of an infrequent stimulus within sequences of frequent ones. In Experiment 1, participants were presented with different line textures. The frequent (standard) and rare (deviant) texture elements differed in their orientation. In Experiment 2, windmill pattern stimuli were presented in which the number of vanes differentiated the deviant and standard stimuli. In Experiment 1 the ERP differences elicited between the oddball deviant and the standard were similar to the differences between the ERPs to the nonadapted and adapted stimuli in the adaptation paradigm. In both paradigms the differences appeared as a posterior negativity with the latency of 120-140 ms. This finding demonstrates that the representation of a sequential rule (successive presentation of the standard) and the violation of this rule are not necessary for deviancy effects to emerge. In Experiment 2 (windmill pattern), in the oddball paradigm the difference potentials appeared as a long-lasting negativity. In the adaptation condition, the later part of this negativity (after 200 ms) was absent. We identified the later part of the oddball difference potential as the genuine visual mismatch negativity-that is, an ERP correlate of sequence violations. The latencies of the difference potentials (deviant minus standard) and the endogenous components (P1 and N1) diverged; therefore, the adaptation of these particular ERP components cannot explain the deviancy effect. Accordingly, the sources contributing to the standard-versus-deviant modulations differed from those related to visual adaptation; that is, they generated distinct ERP components.

  17. The Exact Ground State of the Frenkel-Kontorova Model with Repeated Parabolic Potential: II. Numerical Treatment

    OpenAIRE

    Scheidsteger, T.; Urbschat, H.; Griffiths, R. B.; Schellnhuber, H. J.

    1997-01-01

    A procedure is described for efficiently finding the ground state energy and configuration for a Frenkel-Kontorova model in a periodic potential, consisting of N parabolic segments of identical curvature in each period, through a numerical solution of the convex minimization problem described in the preceding paper. The key elements are the use of subdifferentials to describe the structure of the minimization problem; an intuitive picture of how to solve it, based on motion of quasiparticles;...

  18. A Potential Bone-Targeting Hypotoxic Platinum(II) Complex with an Unusual Cytostatic Mechanism toward Osteosarcoma Cells.

    Science.gov (United States)

    Zhang, Zhenqin; Zhu, Zhenzhu; Luo, Cheng; Zhu, Chengcheng; Zhang, Changli; Guo, Zijian; Wang, Xiaoyong

    2018-03-19

    Osteosarcoma (OS) is the most common primary pediatric bone tumor lethal to children and adolescents. Chemotherapeutic agents such as cisplatin are not effective for OS because of their poor accessibility to this cancer and severe systemic toxicity. In this study, a lipophilic platinum(II) complex bearing a bisphosphonate bone-targeting moiety, cis-[PtL(NH 3 ) 2 Cl]NO 3 {BPP; L = tetraethyl [2-(pyridin-2-yl)ethane-1,1-diyl]bisphosphonate}, was prepared and characterized by NMR, electrospray ionization mass spectrometry, and single-crystal X-ray crystallography. The cytotoxicity of BPP toward OS cell lines U2OS and MG-63 was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. BPP exhibits moderate inhibition against U2OS cells through a mechanism involving both DNA binding and a mevalonate pathway. The acute toxicity of BPP to mice is 7-fold lower than that of cisplatin. The relative low systemic toxicity may result from the steric hindrance of the ligand, which blocks BPP approaching the bases of DNA. The results suggest that incorporating bisphosphonates into a platinum complex not only enhances its bone-targeting property but also minimizes its reactivity toward DNA and thereby lowers the systematic toxicity of the complex. The diminished cytotoxicity of BPP could be compensated for by increasing the therapeutic dose with marginal harm. This strategy provides a new possibility for overcoming the ineffectiveness and systemic toxicity of platinum drugs in the treatment of OS.

  19. Approximate analytical solution of the Dirac equation for pseudospin symmetry with modified Po schl-Teller potential and trigonometric Scarf II non-central potential using asymptotic iteration method

    International Nuclear Information System (INIS)

    Pratiwi, B N; Suparmi, A; Cari, C; Yunianto, M; Husein, A S

    2016-01-01

    We apllied asymptotic iteration method (AIM) to obtain the analytical solution of the Dirac equation in case exact pseudospin symmetry in the presence of modified Pcischl- Teller potential and trigonometric Scarf II non-central potential. The Dirac equation was solved by variables separation into one dimensional Dirac equation, the radial part and angular part equation. The radial and angular part equation can be reduced into hypergeometric type equation by variable substitution and wavefunction substitution and then transform it into AIM type equation to obtain relativistic energy eigenvalue and wavefunctions. Relativistic energy was calculated numerically by Matlab software. And then relativistic energy spectrum and wavefunctions were visualized by Matlab software. The results show that the increase in the radial quantum number n_r causes decrease in the relativistic energy spectrum. The negative value of energy is taken due to the pseudospin symmetry limit. Several quantum wavefunctions were presented in terms of the hypergeometric functions. (paper)

  20. HIF-1α and GLUT-1 Expression in Atypical Endometrial Hyperplasia, Type I and II Endometrial Carcinoma: A Potential Role in Pathogenesis

    Science.gov (United States)

    Abdou, Asmaa Gaber; Wahed, Moshira Mohammed Abdel; Kassem, Hend Abdou

    2016-01-01

    stepwise increase in H- score of GLUT-1 in the studied cases implies its potential role in carcinogenesis of EC. HIF-1α may promote GLUT-1 expression in EC especially surrounding areas of necrosis. The differences between type I and type II EC regarding HIF-1α and GLUT-1 expression may confirm the differences in their aetiopathogenesis. PMID:27437226

  1. Thermodynamics of information processing based on enzyme kinetics: An exactly solvable model of an information pump.

    Science.gov (United States)

    Cao, Yuansheng; Gong, Zongping; Quan, H T

    2015-06-01

    Motivated by the recent proposed models of the information engine [Proc. Natl. Acad. Sci. USA 109, 11641 (2012)] and the information refrigerator [Phys. Rev. Lett. 111, 030602 (2013)], we propose a minimal model of the information pump and the information eraser based on enzyme kinetics. This device can either pump molecules against the chemical potential gradient by consuming the information to be encoded in the bit stream or (partially) erase the information initially encoded in the bit stream by consuming the Gibbs free energy. The dynamics of this model is solved exactly, and the "phase diagram" of the operation regimes is determined. The efficiency and the power of the information machine is analyzed. The validity of the second law of thermodynamics within our model is clarified. Our model offers a simple paradigm for the investigating of the thermodynamics of information processing involving the chemical potential in small systems.

  2. Dynamical generalization of a solvable family of two-electron model atoms with general interparticle repulsion

    International Nuclear Information System (INIS)

    Niehaus, T A; Suhai, S; March, N H

    2008-01-01

    Holas, Howard and March (2003 Phys. Lett. A 310 451) have obtained analytic solutions for ground-state properties of a whole family of two-electron spin-compensated harmonically confined model atoms whose different members are characterized by a specific interparticle potential energy u(r 12 ). Here, we make a start on the dynamic generalization of the harmonic external potential, the motivation being the serious criticism levelled recently against the foundations of time-dependent density-functional theory (e.g., Schirmer and Dreuw 2007 Phys. Rev. A 75 022513). In this context, we derive a simplified expression for the time-dependent electron density for arbitrary interparticle interaction, which is fully determined by a one-dimensional non-interacting Hamiltonian. Moreover, a closed solution for the momentum space density in the Moshinsky model is obtained

  3. Thermodynamics of information processing based on enzyme kinetics: An exactly solvable model of an information pump

    Science.gov (United States)

    Cao, Yuansheng; Gong, Zongping; Quan, H. T.

    2015-06-01

    Motivated by the recent proposed models of the information engine [Proc. Natl. Acad. Sci. USA 109, 11641 (2012), 10.1073/pnas.1204263109] and the information refrigerator [Phys. Rev. Lett. 111, 030602 (2013), 10.1103/PhysRevLett.111.030602], we propose a minimal model of the information pump and the information eraser based on enzyme kinetics. This device can either pump molecules against the chemical potential gradient by consuming the information to be encoded in the bit stream or (partially) erase the information initially encoded in the bit stream by consuming the Gibbs free energy. The dynamics of this model is solved exactly, and the "phase diagram" of the operation regimes is determined. The efficiency and the power of the information machine is analyzed. The validity of the second law of thermodynamics within our model is clarified. Our model offers a simple paradigm for the investigating of the thermodynamics of information processing involving the chemical potential in small systems.

  4. Ultrametricity and memory in a solvable model of self-organized criticality

    International Nuclear Information System (INIS)

    Boettcher, S.; Paczuski, M.

    1996-01-01

    Slowly driven dissipative systems may evolve to a critical state where long periods of apparent equilibrium are punctuated by intermittent avalanches of activity. We present a self-organized critical model of punctuated equilibrium behavior in the context of biological evolution, and solve it in the limit that the number of independent traits for each species diverges. We derive an exact equation of motion for the avalanche dynamics from the microscopic rules. In the continuum limit, avalanches propagate via a diffusion equation with a nonlocal, history dependent potential representing memory. This nonlocal potential gives rise to a non-Gaussian (fat) tail for the subdiffusive spreading of activity. The probability for the activity to spread beyond a distance r in time s decays as √(24/π)s -3/2 x 1/3 exp[-3/4x 1/3 ] for x=r 4 /s>1. The potential represents a hierarchy of time scales that is dynamically generated by the ultrametric structure of avalanches, which can be quantified in terms of open-quote open-quote backward close-quote close-quote avalanches. In addition, a number of other correlation functions characterizing the punctuated equilibrium dynamics are determined exactly

  5. Nickel(II) tetra-aminophthalocyanine modified MWCNTs as potential nanocomposite materials for the development of supercapacitors

    CSIR Research Space (South Africa)

    Chidembo, AT

    2010-11-01

    Full Text Available -aminophthalocyanine modified MWCNTs as potential nanocomposite materials for the development of supercapacitors? Alfred T. Chidembo,a Kenneth I. Ozoemena,*ab Bolade O. Agboola,b Vinay Gupta,c Gregory G. Wildgoose?d and Richard G. Comptond Received 4th August 2009, Accepted.... Lu, Adv. Funct. Mater., 2009, 19, 1. 13 V. Gupta and N. Miura, J. Power Sources, 2006, 157, 616. 14 J. Liu, A. G. Rinzler, H. Dai, J. H. Hanfer, R. K. Bradley, P. J. Boul, A. Lu, T. Iverson, K. Shelimov, C. B. Huffman, F. R. Macias, Y. S. Shon, T...

  6. Potential and flux field landscape theory. II. Non-equilibrium thermodynamics of spatially inhomogeneous stochastic dynamical systems

    International Nuclear Information System (INIS)

    Wu, Wei; Wang, Jin

    2014-01-01

    We have established a general non-equilibrium thermodynamic formalism consistently applicable to both spatially homogeneous and, more importantly, spatially inhomogeneous systems, governed by the Langevin and Fokker-Planck stochastic dynamics with multiple state transition mechanisms, using the potential-flux landscape framework as a bridge connecting stochastic dynamics with non-equilibrium thermodynamics. A set of non-equilibrium thermodynamic equations, quantifying the relations of the non-equilibrium entropy, entropy flow, entropy production, and other thermodynamic quantities, together with their specific expressions, is constructed from a set of dynamical decomposition equations associated with the potential-flux landscape framework. The flux velocity plays a pivotal role on both the dynamic and thermodynamic levels. On the dynamic level, it represents a dynamic force breaking detailed balance, entailing the dynamical decomposition equations. On the thermodynamic level, it represents a thermodynamic force generating entropy production, manifested in the non-equilibrium thermodynamic equations. The Ornstein-Uhlenbeck process and more specific examples, the spatial stochastic neuronal model, in particular, are studied to test and illustrate the general theory. This theoretical framework is particularly suitable to study the non-equilibrium (thermo)dynamics of spatially inhomogeneous systems abundant in nature. This paper is the second of a series

  7. Clonal variation in heavy metal accumulation and biomass production in a poplar coppice culture. II. Vertical distribution and phytoextraction potential

    International Nuclear Information System (INIS)

    Laureysens, I.; Temmerman, L. de; Hastir, T.; Gysel, M. van; Ceulemans, R.

    2005-01-01

    Short rotation coppice cultures (SRC) are intensively managed, high-density plantations of multi-shoot trees. In April 1996, an SRC field trial with 17 different poplar clones was established in Boom (Belgium) on a former waste disposal site. In December 1996 and January 2001, all shoots were cut back to a height of 5 cm to create a coppice culture. For six clones, wood and bark were sampled at the bottom, middle and top of a shoot in August and November 2002. No significant height effect of metal concentration was found, but for wood, metal concentrations generally increased toward the top of the shoot in August, and decreased toward the top of the shoot in November. Phytoextraction potential of a clone was primarily determined by metal concentration and by biomass production. Shoot size and number of shoots per stool were less important, as a high biomass production could be achieved by producing a few large shoots or many smaller shoots. Clone Fritzi Pauley accumulated 1.4 kg ha -1 of Al over two years; Wolterson and Balsam Spire showed a relatively high accumulation of Cd and Zn, i.e. averaging, respectively 47 and 57 g ha -1 for Cd and 2.4 and 2.0 kg ha -1 for Zn over two years. - Poplar shows potential for phytoextraction of Al, Cd and Zn on slightly contaminated soils

  8. Clonal variation in heavy metal accumulation and biomass production in a poplar coppice culture. II. Vertical distribution and phytoextraction potential

    Energy Technology Data Exchange (ETDEWEB)

    Laureysens, I. [University of Antwerp, Campus Drie Eiken, Department of Biology, Universiteitsplein 1, B-2610 Wilrijk (Belgium)]. E-mail: ilse.laureysens@ua.ac.be; Temmerman, L. de [Veterinary and Agrochemical Research Centre (VAR), Leuvensesteenweg 17, B-3080 Tervuren (Belgium); Hastir, T. [University of Antwerp, Campus Drie Eiken, Department of Biology, Universiteitsplein 1, B-2610 Wilrijk (Belgium); Gysel, M. van [University of Antwerp, Campus Drie Eiken, Department of Chemistry, Universiteitsplein 1, B-2610 Wilrijk (Belgium); Ceulemans, R. [University of Antwerp, Campus Drie Eiken, Department of Biology, Universiteitsplein 1, B-2610 Wilrijk (Belgium)

    2005-02-01

    Short rotation coppice cultures (SRC) are intensively managed, high-density plantations of multi-shoot trees. In April 1996, an SRC field trial with 17 different poplar clones was established in Boom (Belgium) on a former waste disposal site. In December 1996 and January 2001, all shoots were cut back to a height of 5 cm to create a coppice culture. For six clones, wood and bark were sampled at the bottom, middle and top of a shoot in August and November 2002. No significant height effect of metal concentration was found, but for wood, metal concentrations generally increased toward the top of the shoot in August, and decreased toward the top of the shoot in November. Phytoextraction potential of a clone was primarily determined by metal concentration and by biomass production. Shoot size and number of shoots per stool were less important, as a high biomass production could be achieved by producing a few large shoots or many smaller shoots. Clone Fritzi Pauley accumulated 1.4 kg ha{sup -1} of Al over two years; Wolterson and Balsam Spire showed a relatively high accumulation of Cd and Zn, i.e. averaging, respectively 47 and 57 g ha{sup -1} for Cd and 2.4 and 2.0 kg ha{sup -1} for Zn over two years. - Poplar shows potential for phytoextraction of Al, Cd and Zn on slightly contaminated soils.

  9. The inverse problem for the one-dimensional Schroedinger equation with an energy-dependent potential. II

    International Nuclear Information System (INIS)

    Jaulent, M.; Jean, C.

    1976-01-01

    The one-dimensional Schroedinger equation y + ''+ ) 7k 2 -V + (k,x){y + =0, x belonging to R, was previously considered when the potential V + (k,x) depends on the energy k 2 in the following way: V + (k,x)=U(x)+2kQ(x), (U(x), Q(x)) belonging to a large class of pairs of real potentials admitting no bound state). The two systems of differential and integral equations then introduced are solved. Then, investigating the inverse scattering problem it is found that a necessary and sufficient condition for one of the functions S + (k) and Ssub(-1)sup(+)(k) to be the scattering matrix associated with a pair (U(x), Q(x)) is that S + (k) (or equivalently Ssub(-1)sup(+)(k) belongs to the class S introduced. This pair is the only one admitting this function as its scattering matrix. Investigating the inverse reflection problem, it is found that a necessary and sufficient condition for a function S 21 + (k) to be the reflection coefficient to the right associated with a pair (U(x), Q(x)) is that S 21 + (k) belongs to the class R introduced. This pair is the only one admitting this function as

  10. Evaluation of linearly solvable Markov decision process with dynamic model learning in a mobile robot navigation task

    Directory of Open Access Journals (Sweden)

    Ken eKinjo

    2013-04-01

    Full Text Available Linearly solvable Markov Decision Process (LMDP is a class of optimal control problem in whichthe Bellman’s equation can be converted into a linear equation by an exponential transformation ofthe state value function (Todorov, 2009. In an LMDP, the optimal value function and the correspondingcontrol policy are obtained by solving an eigenvalue problem in a discrete state space or an eigenfunctionproblem in a continuous state using the knowledge of the system dynamics and the action, state, andterminal cost functions.In this study, we evaluate the effectiveness of the LMDP framework in real robot control, in whichthe dynamics of the body and the environment have to be learned from experience. We first perform asimulation study of a pole swing-up task to evaluate the effect of the accuracy of the learned dynam-ics model on the derived the action policy. The result shows that a crude linear approximation of thenonlinear dynamics can still allow solution of the task, despite with a higher total cost.We then perform real robot experiments of a battery-catching task using our Spring Dog mobile robotplatform. The state is given by the position and the size of a battery in its camera view and two neck jointangles. The action is the velocities of two wheels, while the neck joints were controlled by a visual servocontroller. We test linear and bilinear dynamic models in tasks with quadratic and Guassian state costfunctions. In the quadratic cost task, the LMDP controller derived from a learned linear dynamics modelperformed equivalently with the optimal linear quadratic controller (LQR. In the non-quadratic task, theLMDP controller with a linear dynamics model showed the best performance. The results demonstratethe usefulness of the LMDP framework in real robot control even when simple linear models are usedfor dynamics learning.

  11. Evaluation of linearly solvable Markov decision process with dynamic model learning in a mobile robot navigation task.

    Science.gov (United States)

    Kinjo, Ken; Uchibe, Eiji; Doya, Kenji

    2013-01-01

    Linearly solvable Markov Decision Process (LMDP) is a class of optimal control problem in which the Bellman's equation can be converted into a linear equation by an exponential transformation of the state value function (Todorov, 2009b). In an LMDP, the optimal value function and the corresponding control policy are obtained by solving an eigenvalue problem in a discrete state space or an eigenfunction problem in a continuous state using the knowledge of the system dynamics and the action, state, and terminal cost functions. In this study, we evaluate the effectiveness of the LMDP framework in real robot control, in which the dynamics of the body and the environment have to be learned from experience. We first perform a simulation study of a pole swing-up task to evaluate the effect of the accuracy of the learned dynamics model on the derived the action policy. The result shows that a crude linear approximation of the non-linear dynamics can still allow solution of the task, despite with a higher total cost. We then perform real robot experiments of a battery-catching task using our Spring Dog mobile robot platform. The state is given by the position and the size of a battery in its camera view and two neck joint angles. The action is the velocities of two wheels, while the neck joints were controlled by a visual servo controller. We test linear and bilinear dynamic models in tasks with quadratic and Guassian state cost functions. In the quadratic cost task, the LMDP controller derived from a learned linear dynamics model performed equivalently with the optimal linear quadratic regulator (LQR). In the non-quadratic task, the LMDP controller with a linear dynamics model showed the best performance. The results demonstrate the usefulness of the LMDP framework in real robot control even when simple linear models are used for dynamics learning.

  12. Antiferromagnetic geometric frustration under the influence of the next-nearest-neighbor interaction. An exactly solvable model

    Science.gov (United States)

    Jurčišinová, E.; Jurčišin, M.

    2018-02-01

    The influence of the next-nearest-neighbor interaction on the properties of the geometrically frustrated antiferromagnetic systems is investigated in the framework of the exactly solvable antiferromagnetic spin- 1 / 2 Ising model in the external magnetic field on the square-kagome recursive lattice, where the next-nearest-neighbor interaction is supposed between sites within each elementary square of the lattice. The thermodynamic properties of the model are investigated in detail and it is shown that the competition between the nearest-neighbor antiferromagnetic interaction and the next-nearest-neighbor ferromagnetic interaction changes properties of the single-point ground states but does not change the frustrated character of the basic model. On the other hand, the presence of the antiferromagnetic next-nearest-neighbor interaction leads to the enhancement of the frustration effects with the formation of additional plateau and single-point ground states at low temperatures. Exact expressions for magnetizations and residual entropies of all ground states of the model are found. It is shown that the model exhibits various ground states with the same value of magnetization but different macroscopic degeneracies as well as the ground states with different values of magnetization but the same value of the residual entropy. The specific heat capacity is investigated and it is shown that the model exhibits the Schottky-type anomaly behavior in the vicinity of each single-point ground state value of the magnetic field. The formation of the field-induced double-peak structure of the specific heat capacity at low temperatures is demonstrated and it is shown that its very existence is directly related to the presence of highly macroscopically degenerated single-point ground states in the model.

  13. Explore or exploit? A generic model and an exactly solvable case.

    Science.gov (United States)

    Gueudré, Thomas; Dobrinevski, Alexander; Bouchaud, Jean-Philippe

    2014-02-07

    Finding a good compromise between the exploitation of known resources and the exploration of unknown, but potentially more profitable choices, is a general problem, which arises in many different scientific disciplines. We propose a stylized model for these exploration-exploitation situations, including population or economic growth, portfolio optimization, evolutionary dynamics, or the problem of optimal pinning of vortices or dislocations in disordered materials. We find the exact growth rate of this model for treelike geometries and prove the existence of an optimal migration rate in this case. Numerical simulations in the one-dimensional case confirm the generic existence of an optimum.

  14. Solvable spectral problems from 2d CFT and \\mathscr{N} = 2 gauge theories

    Science.gov (United States)

    Piątek, M. R.; Pietrykowski, A. R.

    2018-02-01

    The so-called 2d/4d correspondences connect two-dimensional conformal field theory (2d CFT), \\mathscr{N} = 2 supersymmetric gauge theories and quantum integrable systems. The latter in the simplest case of the SU(2) gauge group are nothing but the quantum-mechanical systems. In the present article we summarize our recent results and list open problems concerning an application of the aforementioned dualities in the studies of spectral problems for some Schrödinger operators with Mathieu-type periodic, periodic PT-symmetric and (Heun’s) elliptic potentials.

  15. Explore or Exploit? A Generic Model and an Exactly Solvable Case

    Science.gov (United States)

    Gueudré, Thomas; Dobrinevski, Alexander; Bouchaud, Jean-Philippe

    2014-02-01

    Finding a good compromise between the exploitation of known resources and the exploration of unknown, but potentially more profitable choices, is a general problem, which arises in many different scientific disciplines. We propose a stylized model for these exploration-exploitation situations, including population or economic growth, portfolio optimization, evolutionary dynamics, or the problem of optimal pinning of vortices or dislocations in disordered materials. We find the exact growth rate of this model for treelike geometries and prove the existence of an optimal migration rate in this case. Numerical simulations in the one-dimensional case confirm the generic existence of an optimum.

  16. cobalt (ii), nickel (ii)

    African Journals Online (AJOL)

    DR. AMINU

    Department of Chemistry Bayero University, P. M. B. 3011, Kano, Nigeria. E-mail: hnuhu2000@yahoo.com. ABSTRACT. The manganese (II), cobalt (II), nickel (II) and .... water and common organic solvents, but are readily soluble in acetone. The molar conductance measurement [Table 3] of the complex compounds in.

  17. Potential of Reinforced Indonesian Glulam Beams Using Grade I (Bengkirai, Grade II (Kamper, Grade III (Nyatoh Woods for Use in Structural Wood Design

    Directory of Open Access Journals (Sweden)

    Saptahari Sugiri

    2016-05-01

    Full Text Available Wood is a natural resource that is renewable and available in various species in tropical countries. Its abundancy in nature makes it easy to obtain, thus making it a nature friendly material for use in construction. Indonesia is the most important source of tropical wood in the world after Brazil, making the use of wood for structural elements very desirable. It is estimated that 4000 different varieties of wood exist in Indonesia. This estimate is based on the herbarium species collected by the Forestry Research Institute, currently counting nearly 4000 types of trees with a diameter of more than 40 cm. In the Indonesian wood structure code, the strength of woods is divided into 3 grades (grade I, II and III. This paper presents an evaluation of the mechanical properties of glulam wood sourced from native Indonesian timber: Bengkirai wood (grade I, Kamper wood (grade II, and Nyatoh wood (grade III, thus proving the potential for Indonesian wood as industrial structural elements in wooden constructions.

  18. Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase.

    Science.gov (United States)

    Jang, Dae Sik; Park, Eun Jung; Hawthorne, Michael E; Vigo, Jose Schunke; Graham, James G; Cabieses, Fernando; Santarsiero, Bernard D; Mesecar, Andrew D; Fong, Harry H S; Mehta, Rajendra G; Pezzuto, John M; Kinghorn, A Douglas

    2002-10-23

    A new bicyclic diarylheptanoid, rel-(3S,4aR,10bR)-8-hydroxy-3-(4-hydroxyphenyl)-9-methoxy-4a,5,6,10b-tetrahydro-3H-naphtho[2,1-b]pyran (1), as well as four known compounds, 1,2-dihydro-1,2,3-trihydroxy-9-(4-methoxyphenyl)phenalene (2), hydroxyanigorufone (3), 2-(4-hydroxyphenyl)naphthalic anhydride (4), and 1,7-bis(4-hydroxyphenyl)hepta-4(E),6(E)-dien-3-one (5), were isolated from an ethyl acetate-soluble fraction of the methanol extract of the fruits of Musa x paradisiaca cultivar, using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa1c1c7 mouse hepatoma cells to monitor chromatographic fractionation. The structure and relative stereochemistry of compound 1 were elucidated unambiguously by one- and two-dimensional NMR experiments ((1)H NMR, (13)C NMR, DEPT, COSY, HMQC, HMBC, and NOESY) and single-crystal X-ray diffraction analysis. Isolates 1-5 were evaluated for their potential cancer chemopreventive properties utilizing an in vitro assay to determine quinone reductase induction and a mouse mammary organ culture assay.

  19. Charged black holes in string-inspired gravity II. Mass inflation and dependence on parameters and potentials

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Jakob [KISTI,Daejeon 305-806 (Korea, Republic of); Yeom, Dong-han [Leung Center for Cosmology and Particle Astrophysics, National Taiwan University,Taipei 10617, Taiwan (China)

    2015-09-07

    We investigate the relation between the existence of mass inflation and model parameters of string-inspired gravity models. In order to cover various models, we investigate a Brans-Dicke theory that is coupled to a U(1) gauge field. By tuning a model parameter that decides the coupling between the Brans-Dicke field and the electromagnetic field, we can make both of models such that the Brans-Dicke field is biased toward strong or weak coupling directions after gravitational collapses. We observe that as long as the Brans-Dicke field is biased toward any (strong or weak) directions, there is no Cauchy horizon and no mass inflation. Therefore, we conclude that to induce a Cauchy horizon and mass inflation inside a charged black hole, either there is no bias of the Brans-Dicke field as well as no Brans-Dicke hair outside the horizon or such a biased Brans-Dicke field should be well trapped and controlled by a potential.

  20. Quality of Life Theory II. Quality of Life as the Realization of Life Potential: A Biological Theory of Human Being

    Directory of Open Access Journals (Sweden)

    Soren Ventegodt

    2003-01-01

    Full Text Available This review presents one of the eight theories of the quality of life (QOL used for making the SEQOL (self-evaluation of quality of life questionnaire or the quality of life as realizing life potential. This theory is strongly inspired by Maslow and the review furthermore serves as an example on how to fulfill the demand for an overall theory of life (or philosophy of life, which we believe is necessary for global and generic quality-of-life research.Whereas traditional medical science has often been inspired by mechanical models in its attempts to understand human beings, this theory takes an explicitly biological starting point. The purpose is to take a close view of life as a unique entity, which mechanical models are unable to do. This means that things considered to be beyond the individual's purely biological nature, notably the quality of life, meaning in life, and aspirations in life, are included under this wider, biological treatise. Our interpretation of the nature of all living matter is intended as an alternative to medical mechanism, which dates back to the beginning of the 20th century. New ideas such as the notions of the human being as nestled in an evolutionary and ecological context, the spontaneous tendency of self-organizing systems for realization and concord, and the central role of consciousness in interpreting, planning, and expressing human reality are unavoidable today in attempts to scientifically understand all living matter, including human life.

  1. An update on the PT-symmetric complexified Scarf II potential, spectral singularities and some remarks on the rationally extended supersymmetric partners

    International Nuclear Information System (INIS)

    Bagchi, B; Quesne, C

    2010-01-01

    The PT-symmetric complexified Scarf II potential V(x) = -V 1 sech 2 x + iV 2 sechxtanh x, V 1 > 0, V 2 ≠ 0, is revisited to study the interplay among its coupling parameters. The existence of an isolated real and positive energy level that has recently been identified as a spectral singularity or zero-width resonance is here demonstrated through the behaviour of the corresponding wavefunctions and some property of the associated pseudo-norms is pointed out. We also construct four different rationally extended supersymmetric partners to V(x), which are PT-symmetric or complex non-PT-symmetric according to the coupling parameters range. A detailed study of one of these partners reveals that SUSY preserves the V(x) spectral singularity existence.

  2. Assessing student expertise in introductory physics with isomorphic problems. II. Effect of some potential factors on problem solving and transfer

    Directory of Open Access Journals (Sweden)

    Chandralekha Singh

    2008-03-01

    Full Text Available In this paper, we explore the use of isomorphic problem pairs (IPPs to assess introductory physics students’ ability to solve and successfully transfer problem-solving knowledge from one context to another in mechanics. We call the paired problems “isomorphic” because they require the same physics principle to solve them. We analyze written responses and individual discussions for a range of isomorphic problems. We examine potential factors that may help or hinder transfer of problem-solving skills from one problem in a pair to the other. For some paired isomorphic problems, one context often turned out to be easier for students in that it was more often correctly solved than the other. When quantitative and conceptual questions were paired and given back to back, students who answered both questions in the IPP often performed better on the conceptual questions than those who answered the corresponding conceptual questions only. Although students often took advantage of the quantitative counterpart to answer a conceptual question of an IPP correctly, when only given the conceptual question, students seldom tried to convert it into a quantitative question, solve it, and then reason about the solution conceptually. Even in individual interviews when students who were given only conceptual questions had difficulty and the interviewer explicitly encouraged them to convert the conceptual question into the corresponding quantitative problem by choosing appropriate variables, a majority of students were reluctant and preferred to guess the answer to the conceptual question based upon their gut feeling. Misconceptions associated with friction in some problems were so robust that pairing them with isomorphic problems not involving friction did not help students discern their underlying similarities. Alternatively, from the knowledge-in-pieces perspective, the activation of the knowledge resource related to friction was so strongly and automatically

  3. Solvable light-front model of the electromagnetic form factor of the relativistic two-body bound state in 1+1 dimensions

    International Nuclear Information System (INIS)

    Mankiewicz, L.; Sawicki, M.

    1989-01-01

    Within a relativistically correct yet analytically solvable model of light-front quantum mechanics we construct the electromagnetic form factor of the two-body bound state and we study the validity of the static approximation to the full form factor. Upon comparison of full form factors calculated for different values of binding energy we observe an unexpected effect that for very strongly bound states further increase in binding leads to an increase in the size of the bound system. A similar effect is found for another quantum-mechanical model of relativistic dynamics

  4. Unique solvability of a non-linear non-local boundary-value problem for systems of non-linear functional differential equations

    Czech Academy of Sciences Publication Activity Database

    Dilna, N.; Rontó, András

    2010-01-01

    Roč. 60, č. 3 (2010), s. 327-338 ISSN 0139-9918 R&D Projects: GA ČR(CZ) GA201/06/0254 Institutional research plan: CEZ:AV0Z10190503 Keywords : non-linear boundary value-problem * functional differential equation * non-local condition * unique solvability * differential inequality Subject RIV: BA - General Mathematics Impact factor: 0.316, year: 2010 http://link.springer.com/article/10.2478%2Fs12175-010-0015-9

  5. Exactly solvable model of the two-dimensional electrical double layer.

    Science.gov (United States)

    Samaj, L; Bajnok, Z

    2005-12-01

    We consider equilibrium statistical mechanics of a simplified model for the ideal conductor electrode in an interface contact with a classical semi-infinite electrolyte, modeled by the two-dimensional Coulomb gas of pointlike unit charges in the stability-against-collapse regime of reduced inverse temperatures 0layer) carries some nonzero surface charge density. The model is mappable onto an integrable semi-infinite sine-Gordon theory with Dirichlet boundary conditions. The exact form-factor and boundary state information gained from the mapping provide asymptotic forms of the charge and number density profiles of electrolyte particles at large distances from the interface. The result for the asymptotic behavior of the induced electric potential, related to the charge density via the Poisson equation, confirms the validity of the concept of renormalized charge and the corresponding saturation hypothesis. It is documented on the nonperturbative result for the asymptotic density profile at a strictly nonzero beta that the Debye-Hückel beta-->0 limit is a delicate issue.

  6. Additional file 4: of MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis

    OpenAIRE

    Lipski, Deborah; Dewispelaere, RÊmi; Foucart, Vincent; Caspers, Laure; Defrance, Matthieu; Bruyns, Catherine; Willermain, François

    2017-01-01

    Figure S4. MHC class II expression in the retina during classical EAU. Three weeks after immunization, eye cryosections were prepared and stained for MHC class II (green) and IBA1 (red) or endoglin (magenta) detection. Cell nuclei were stained with Hoechst (blue). Each picture was chosen as representative of an experiment conducted on six or more animals. A. MHC class II and IBA1 expression. B. MHC class II and endoglin expression. (PPTX 7276 kb)

  7. Determination of formal redox potentials in aqueous solution of copper(II) complexes with ligands having nitrogen and oxygen donor atoms and comparison with their EPR and UV-Vis spectral features.

    Science.gov (United States)

    Tabbì, Giovanni; Giuffrida, Alessandro; Bonomo, Raffaele P

    2013-11-01

    Formal redox potentials in aqueous solution were determined for copper(II) complexes with ligands having oxygen and nitrogen as donor atoms. All the chosen copper(II) complexes have well-known stereochemistries (pseudo-octahedral, square planar, square-based pyramidal, trigonal bipyramidal or tetrahedral) as witnessed by their reported spectroscopic, EPR and UV-visible (UV-Vis) features, so that a rough correlation between the measured redox potential and the typical geometrical arrangement of the copper(II) complex could be established. Negative values have been obtained for copper(II) complexes in tetragonally elongated pseudo-octahedral geometries, when measured against Ag/AgCl reference electrode. Copper(II) complexes in tetrahedral environments (or flattened tetrahedral geometries) show positive redox potential values. There is a region, always in the field of negative redox potentials which groups the copper(II) complexes exhibiting square-based pyramidal arrangements. Therefore, it is suggested that a measurement of the formal redox potential could be of great help, when some ambiguities might appear in the interpretation of spectroscopic (EPR and UV-Vis) data. Unfortunately, when the comparison is made between copper(II) complexes in square-based pyramidal geometries and those in square planar environments (or a pseudo-octahedral) a little perturbed by an equatorial tetrahedral distortion, their redox potentials could fall in the same intermediate region. In this case spectroscopic data have to be handled with great care in order to have an answer about a copper complex geometrical characteristics. © 2013.

  8. Resistance Training in Type II Diabetes Mellitus: Impact on Areas of Metabolic Dysfunction in Skeletal Muscle and Potential Impact on Bone

    Directory of Open Access Journals (Sweden)

    Richard J. Wood

    2012-01-01

    Full Text Available The prevalence of Type II Diabetes mellitus (T2DM is increasing rapidly and will continue to be a major healthcare expenditure burden. As such, identification of effective lifestyle treatments is paramount. Skeletal muscle and bone display metabolic and functional disruption in T2DM. Skeletal muscle in T2DM is characterized by insulin resistance, impaired glycogen synthesis, impairments in mitochondria, and lipid accumulation. Bone quality in T2DM is decreased, potentially due to the effects of advanced glycation endproducts on collagen, impaired osteoblast activity, and lipid accumulation. Although exercise is widely recognized as an important component of treatment for T2DM, the focus has largely been on aerobic exercise. Emerging research suggests that resistance training (strength training may impose potent and unique benefits in T2DM. The purpose of this review is to examine the role of resistance training in treating the dysfunction in skeletal muscle and the potential role for resistance training in treating the associated dysfunction in bone.

  9. Computational screening of Six Antigens for potential MHC class II restricted epitopes and evaluating its CD4+ T-Cell Responsiveness against Visceral Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Manas Ranjan

    2017-12-01

    Full Text Available Visceral leishmaniasis is one of the most neglected tropical diseases for which no vaccine exists. In spite of extensive efforts, no successful vaccine is available against this dreadful infectious disease. To support the vaccine development, immunoinformatics approach was applied to search for potential MHC-classII restricted epitopes that can activate the immune cells. Initially, a total of 37 epitopes derived from six, stage dependent over expressed antigens were predicted, which were presented by at least 26 diverse MHC class II alleles including: DRB10101, DRB10301, DRB10401, DRB10404, DRB10405, DRB10701, DRB10802, DRB10901, DRB11101, DRB11302, DRB11501, DRB30101, DRB40101, DRB50101, DPA10103-DPB10401, DPA10103-DPB10201, DPA10201-DPB10101, DPA10103-DPB10301_DPB10401, DPA10301-DPB10402, DPA10201-DPB105021, DQA10102-DQB10602, DQA10401-DQB10402, DQA10501-QB10201, DQA10501-DQB10301, DQA10301-DQB10302 and DQA10101-DQB10501. Based on the population coverage analysis and HLA cross presentation ability, six epitopes namely, FDLFLFSNGAVVWWG (P1, YPVYPFLASNAALLN (P2, VYPFLASNAALLNLI (P3, LALLIMLYALIATQF (P4, LIMLYALIATQFSDD (P5, IMLYALIATQFSDDA (P6 were selected for further analysis. Stimulation with synthetic peptide alone or as a cocktail triggered the intracellular IFN-γ production. Moreover, specific IgG class of antibodies was detected in the serum of active VL cases against P1, P4, P and P6 in order to evaluate peptide effect on humoral immune response. Additionally, most of the peptides, except P2, were found to be non-inducer of CD4+ IL-10 against both active VL as well as treated VL subjects. Peptide immunogenicity was validated in BALB/c mice immunized with cocktail of synthetic peptide emulsified in complete Freund’s adjuvant/incomplete Freund’s adjuvant. The immunized splenocytes induced strong spleen cell proliferation upon parasite re-stimulation. Furthermore, an increased IFN-γ, IL-12, IL-17 and IL-22 production augmented with

  10. Salt-induced variation in some potential physiochemical attributes of two genetically diverse spring wheat (triticum aestivum L.) cultivars: photosynthesis and photosystem II efficiency

    International Nuclear Information System (INIS)

    Ashraf, M.A.; Ashraf, M.

    2011-01-01

    Variation in salt tolerance potential of two contrasting wheat cultivars (salt tolerant S-24 and moderately salt sensitive MH-97) at different growth stages was observed when these wheat cultivars were exposed to salinity stress in hydroponic culture. Salinity caused a marked reduction in photosynthetic pigments, transpiration and photos synthetic rates, and stomatal conductance at early growth stages in both wheat cultivars, being more prominent in cv. MH-97. In addition, a marked salt-induced alteration was observed in different attributes of chlorophyll fluorescence. On the basis of physiological characterization of these two wheat cultivars at different growth stages, it was inferred that cv. S-24 exhibited higher salinity tolerance at all growth stages in terms of less salinity-induced degradation of photosynthetic pigments, higher photosynthetic rates, maintenance of photosystem II under salinity stress as compared to that in cv. MH-97. In view of the results presented here, it is evident that wheat plants were prone to adverse effects of salinity at early growth stages as compared to later growth stages. (author)

  11. Vibrational, structural and electronic properties investigation by DFT calculations and molecular docking studies with DNA topoisomerase II of strychnobrasiline type alkaloids: A theoretical approach for potentially bioactive molecules

    Science.gov (United States)

    Costa, Renyer A.; Oliveira, Kelson M. T.; Costa, Emmanoel Vilaça; Pinheiro, Maria L. B.

    2017-10-01

    A combined experimental and theoretical DFT study of the structural, vibrational and electronic properties of strychnobrasiline and 12-hydroxy-10,11-dimethoxystrychnobrasiline is presented using the Becke three-parameter Lee-Yang-Parr function (B3LYP) and 6-311G(2d,p) basis set. The theoretical geometry optimization data were compared with the X-ray data for a similar structure in the associated literature, showing close values. The calculated HOMO-LUMO gap values showed that the presence of substituents in the benzene ring influences the quantum properties which are directly related to the reactive properties. Theoretical UV spectra agreed well with the measured experimental data, with bands assigned. In addition, Natural Bond Orbitals (NBOs), Mapped molecular electrostatic potential surface (MEPS) and NLO calculations were also performed at the same theory level. The theoretical vibrational analysis revealed several characteristic vibrations that may be used as a diagnostic tool for other strychnobrasiline type alkaloids, simplifying their identification and structural characterization. Molecular docking calculations with DNA Topoisomerase II-DNA complex showed binding free energies values of -8.0 and -9.5 kcal/mol for strychnobrasiline and 12-hydroxy-10,11-dimethoxystrychnobrasiline respectively, while for amsacrine, used for the treatment of leukemia, the binding free energy ΔG presented a value of -10.0 kcal/mol, suggesting that strychnobrasiline derivative alkaloids might exhibit an antineoplastic activity.

  12. Characterization of a tricationic trigonal bipyramidal iron(IV) cyanide complex, with a very high reduction potential, and its iron(II) and iron(III) congeners.

    Science.gov (United States)

    England, Jason; Farquhar, Erik R; Guo, Yisong; Cranswick, Matthew A; Ray, Kallol; Münck, Eckard; Que, Lawrence

    2011-04-04

    Currently, there are only a handful of synthetic S = 2 oxoiron(IV) complexes. These serve as models for the high-spin (S = 2) oxoiron(IV) species that have been postulated, and confirmed in several cases, as key intermediates in the catalytic cycles of a variety of nonheme oxygen activating enzymes. The trigonal bipyramidal complex [Fe(IV)(O)(TMG(3)tren)](2+) (1) was both the first S = 2 oxoiron(IV) model complex to be generated in high yield and the first to be crystallographically characterized. In this study, we demonstrate that the TMG(3)tren ligand is also capable of supporting a tricationic cyanoiron(IV) unit, [Fe(IV)(CN)(TMG(3)tren)](3+) (4). This complex was generated by electrolytic oxidation of the high-spin (S = 2) iron(II) complex [Fe(II)(CN)(TMG(3)tren)](+) (2), via the S = 5/2 complex [Fe(III)(CN)(TMG(3)tren)](2+) (3), the progress of which was conveniently monitored by using UV-vis spectroscopy to follow the growth of bathochromically shifting ligand-to-metal charge transfer (LMCT) bands. A combination of X-ray absorption spectroscopy (XAS), Mössbauer and NMR spectroscopies was used to establish that 4 has a S = 0 iron(IV) center. Consistent with its diamagnetic iron(IV) ground state, extended X-ray absorption fine structure (EXAFS) analysis of 4 indicated a significant contraction of the iron-donor atom bond lengths, relative to those of the crystallographically characterized complexes 2 and 3. Notably, 4 has an Fe(IV/III) reduction potential of ∼1.4 V vs Fc(+/o), the highest value yet observed for a monoiron complex. The relatively high stability of 4 (t(1/2) in CD(3)CN solution containing 0.1 M KPF(6) at 25 °C ≈ 15 min), as reflected by its high-yield accumulation via slow bulk electrolysis and amenability to (13)C NMR at -40 °C, highlights the ability of the sterically protecting, highly basic peralkylguanidyl donors of the TMG(3)tren ligand to support highly charged high-valent complexes.

  13. Optimal recombination in genetic algorithms for combinatorial optimization problems: Part II

    Directory of Open Access Journals (Sweden)

    Eremeev Anton V.

    2014-01-01

    Full Text Available This paper surveys results on complexity of the optimal recombination problem (ORP, which consists in finding the best possible offspring as a result of a recombination operator in a genetic algorithm, given two parent solutions. In Part II, we consider the computational complexity of ORPs arising in genetic algorithms for problems on permutations: the Travelling Salesman Problem, the Shortest Hamilton Path Problem and the Makespan Minimization on Single Machine and some other related problems. The analysis indicates that the corresponding ORPs are NP-hard, but solvable by faster algorithms, compared to the problems they are derived from.

  14. A Family of Exactly Solvable Radial Quantum Systems on Space of Non-Constant Curvature with Accidental Degeneracy in the Spectrum

    Directory of Open Access Journals (Sweden)

    Orlando Ragnisco

    2010-12-01

    Full Text Available A novel family of exactly solvable quantum systems on curved space is presented. The family is the quantum version of the classical Perlick family, which comprises all maximally superintegrable 3-dimensional Hamiltonian systems with spherical symmetry. The high number of symmetries (both geometrical and dynamical exhibited by the classical systems has a counterpart in the accidental degeneracy in the spectrum of the quantum systems. This family of quantum problem is completely solved with the techniques of the SUSYQM (supersymmetric quantum mechanics. We also analyze in detail the ordering problem arising in the quantization of the kinetic term of the classical Hamiltonian, stressing the link existing between two physically meaningful quantizations: the geometrical quantization and the position dependent mass quantization.

  15. Exactly solvable model of transitional nuclei based on dual algebraic structure for the three level pairing model in the framework of sdg interacting boson model

    Science.gov (United States)

    Jafarizadeh, M. A.; Ranjbar, Z.; Fouladi, N.; Ghapanvari, M.

    2018-01-01

    In this paper, a successful algebraic method based on the dual algebraic structure for three level pairing model in the framework of sdg IBM is proposed for transitional nuclei which show transitional behavior from spherical to gamma-unstable quantum shape phase transition. In this method complicated sdg Hamiltonian, which is a three level pairing Hamiltonian is determined easily via the exactly solvable method. This description provides a better interpretation of some observables such as BE (4) in nuclei which exhibits the necessity of inclusion of g boson in the sd IBM, while BE (4) cannot be explained in the sd boson model. Some observables such as Energy levels, BE (2), BE (4), the two neutron separation energies signature splitting of the γ-vibrational band and expectation values of the g-boson number operator are calculated and examined for 46 104 - 110Pd isotopes.

  16. Unified Treatment of a Class of Spherically Symmetric Potentials: Quasi-Exact Solution

    International Nuclear Information System (INIS)

    Baradaran, M.; Panahi, H.

    2016-01-01

    We investigate the Schrödinger equation for a class of spherically symmetric potentials in a simple and unified manner using the Lie algebraic approach within the framework of quasi-exact solvability. We illustrate that all models give rise to the same basic differential equation, which is expressible as an element of the universal enveloping algebra of sl(2). Then, we obtain the general exact solutions of the problem by employing the representation theory of sl(2) Lie algebra.

  17. DNA barcoding in a biodiversity hot spot: potential value for the identification of Malagasy Euphorbia L. listed in CITES Appendices I and II.

    Science.gov (United States)

    Aubriot, Xavier; Lowry, Porter P; Cruaud, Corinne; Couloux, Arnaud; Haevermans, Thomas

    2013-01-01

    The island of Madagascar is a key hot spot for the genus Euphorbia, with at least 170 native species, almost all endemic. Threatened by habitat loss and illegal collection of wild plants, nearly all Malagasy Euphorbia are listed in CITES Appendices I and II. The absence of a reliable taxonomic revision makes it particularly difficult to identify these plants, even when fertile, and thereby compromises the application of CITES regulations. DNA barcoding, which can facilitate species-level identification irrespective of developmental stage and the presence of flowers or fruits, may be a promising tool for monitoring and controlling trade involving threatened species. In this study, we test the potential value of barcoding on 41 Euphorbia species representative of the genus in Madagascar, using the two widely adopted core barcode markers (matK and rbcL), along with two additional DNA regions, nuclear internal transcribed spacer (ITS) and the chloroplastic intergenic spacer psbA-trnH. For each marker and for selected marker combinations, inter- and intraspecific distance estimates and species discrimination rates are calculated. Results using just the 'official' barcoding markers yield overlapping inter- and intraspecific ranges and species discrimination rates below 60%. When ITS is used, whether alone or in combination with the core markers, species discrimination increases to nearly 100%, whereas the addition of psbA-trnH produces less satisfactory results. This study, the first ever to test barcoding on the large, commercially important genus Euphorbia shows that this method could be developed into a powerful identification tool and thereby contribute to more effective application of CITES regulations. © 2012 Blackwell Publishing Ltd.

  18. A Phase II randomised controlled trial assessing the feasibility, acceptability and potential effectiveness of Dignity Therapy for older people in care homes: Study protocol

    Directory of Open Access Journals (Sweden)

    Richardson Alison

    2009-03-01

    Full Text Available Abstract Background Although most older people living in nursing homes die there, there is a dearth of robust evaluations of interventions to improve their end-of-life care. Residents usually have multiple health problems making them heavily reliant on staff for their care, which can erode their sense of dignity. Dignity Therapy has been developed to help promote dignity and reduce distress. It comprises a recorded interview, which is transcribed, edited then returned to the patient, who can bequeath it to people of their choosing. Piloting has suggested that Dignity Therapy is beneficial to people dying of cancer and their families. The aims of this study are to assess the feasibility, acceptability and potential effectiveness of Dignity Therapy to reduce psychological and spiritual distress in older people reaching the end of life in care homes, and to pilot the methods for a Phase III RCT. Methods/design A randomised controlled open-label trial. Sixty-four residents of care homes for older people are randomly allocated to one of two groups: (i Intervention (Dignity Therapy offered in addition to any standard care, and (ii Control group (standard care. Recipients of the "generativity" documents are asked their views on taking part in the study and the therapy. Both quantitative and qualitative outcomes are assessed in face-to-face interviews at baseline and at approximately one and eight weeks after the intervention (equivalent in the control group. The primary outcome is residents' sense of dignity (potential effectiveness assessed by the Patient Dignity Inventory. Secondary outcomes for residents include depression, hopefulness and quality of life. In view of the relatively small sample size, quantitative analysis is mainly descriptive. The qualitative analysis uses the Framework method. Discussion Dignity Therapy is brief, can be done at the bedside and could help both patients and their families. This detailed exploratory research shows if

  19. A Phase II randomised controlled trial assessing the feasibility, acceptability and potential effectiveness of dignity therapy for older people in care homes: study protocol.

    Science.gov (United States)

    Hall, Sue; Chochinov, Harvey; Harding, Richard; Murray, Scott; Richardson, Alison; Higginson, Irene J

    2009-03-24

    Although most older people living in nursing homes die there, there is a dearth of robust evaluations of interventions to improve their end-of-life care. Residents usually have multiple health problems making them heavily reliant on staff for their care, which can erode their sense of dignity. Dignity Therapy has been developed to help promote dignity and reduce distress. It comprises a recorded interview, which is transcribed, edited then returned to the patient, who can bequeath it to people of their choosing. Piloting has suggested that Dignity Therapy is beneficial to people dying of cancer and their families. The aims of this study are to assess the feasibility, acceptability and potential effectiveness of Dignity Therapy to reduce psychological and spiritual distress in older people reaching the end of life in care homes, and to pilot the methods for a Phase III RCT. A randomised controlled open-label trial. Sixty-four residents of care homes for older people are randomly allocated to one of two groups: (i) Intervention (Dignity Therapy offered in addition to any standard care), and (ii) Control group (standard care). Recipients of the "generativity" documents are asked their views on taking part in the study and the therapy. Both quantitative and qualitative outcomes are assessed in face-to-face interviews at baseline and at approximately one and eight weeks after the intervention (equivalent in the control group). The primary outcome is residents' sense of dignity (potential effectiveness) assessed by the Patient Dignity Inventory. Secondary outcomes for residents include depression, hopefulness and quality of life. In view of the relatively small sample size, quantitative analysis is mainly descriptive. The qualitative analysis uses the Framework method. Dignity Therapy is brief, can be done at the bedside and could help both patients and their families. This detailed exploratory research shows if it is feasible to offer Dignity Therapy to residents of

  20. Triple Quenching of a Novel Self-Enhanced Ru(II) Complex by Hemin/G-Quadruplex DNAzymes and Its Potential Application to Quantitative Protein Detection.

    Science.gov (United States)

    Zhao, Min; Liao, Ni; Zhuo, Ying; Chai, Ya-Qin; Wang, Ji-Peng; Yuan, Ruo

    2015-08-04

    Herein, a novel "on-off" electrochemiluminescence (ECL) aptasensor for highly sensitive determination of thrombin has been constructed based on the triple quenching of the effect of hemin/G-quadruplex DNAzymes upon the Ru(II) complex-based ECL system. First, a strong initial ECL signal was achieved by the dual amplification strategies of (i) intramolecular coreaction of a self-enhanced Ru(II)-based molecule (PTCA-PEI-Ru(II)) and (ii) intermolecular coreaction between PTCA-PEI-Ru(II) and nicotinamide adenine dinucleotide (NADH), which was named the signal-on state. Then, a novel triple quenching of the effect of multifunctional hemin/G-quadruplex DNAzymes upon the Ru(II) complex-based ECL system was designed to realize the desirable signal-off state, which was outlined as follows: (i) the hemin/G-quadruplex DNAzymes mimicked NADH oxidase to oxidize NADH and in situ generate the H2O2, consuming the coreactant of NADH; (ii) its active center of hemin could oxidize the excited state PTCA-PEI-Ru(II)* to PTCA-PEI-Ru(III), making the energy and electron transfer quench; (iii) it also acted as horseradish peroxidase (HRP) to catalyze the H2O2 for in situ producing the quencher of O2. Based on triple quenching of the effect of hemin/G-quadruplex DNAzymes, the highly sensitive "on-off" thrombin aptasensor was developed with a wide linear detection range of 1.0 × 10(-14) M to 1.0 × 10(-10) M and a detection limit down to the femtomolar level.

  1. Sulfite induced autoxidation of Cu(II/tetra/ penta and hexaglycine complexes: spectrophotometric and rotating-ring-disk glassy carbon electrode studies and analytical potentialities

    Directory of Open Access Journals (Sweden)

    Alipázaga Maria V.

    2003-01-01

    Full Text Available The oxidation of Cu(II complexes with tetra, penta and hexaglycine in borate buffer aqueous solution, by dissolved oxygen is strongly accelerated by sulfite. The formation of Cu(III complexes with maximum absorbances at 250 nm (e = 9000 mol-1 L cm-1 and 365 nm (e = 7120 mol-1 L cm-1 was also characterized by using rotating ring-disk voltammetry, whose anodic and cathodic components were observed in voltammograms recorded in solutions containing Cu(II. Voltammograms, obtained at various rotation speeds, showed that the Cu(III species electrochemically generated is not stable over the entire time window of the experiment and in solutions containing tetraglycine the overall limiting current is controlled by the kinetics of an equilibrium involving Cu(II species.The calculated first order rate constant of the decomposition was 4.37x10-3 s-1. Electrochemical experiments carried out in Cu(II solutions after the addition of relatively small amounts of sulfite demonstrated that the Cu(III species formed in the chemical reaction is the same as the one collected at the ring electrode when Cu(II is oxidized at the disk electrode in ring-disk voltammetry. The concentration of Cu(III complexes is proportional to the amount of added sulfite and the results indicated that indirect analytical methods for sulfite may be developed by means of spectrophotometric or amperometric detection of the chemically generated product.

  2. Doppler-guided hemorrhoidal artery ligation (DG-HAL): a safe treatment of II-III degree hemorrhoids for all patients. Could it be potentially also good prophylaxis?

    Science.gov (United States)

    Testa, A; Torino, G

    2010-06-01

    Doppler-guided hemorrhoidal artery ligation (HAL Doppler) is an innovative hemorrhoid treatment mainly utilised for II-III degree where bleeding is a predominant symptom. This procedure aims at dearterialization of the internal hemorrhoidal plexus by ligation of the terminal branches of the superior rectal artery detected using a special proctoscope and ultrasound system; the procedure is performed entirely above the dentate line, so it is genuinely painless. The aim of this study was to evaluate the efficacy, safety and invasivity of HAL Doppler technique to treat II and III degree hemorrhoids. The authors treated 148 patients, from May 2002 to December 2007, principally affected by II-III degree hemorrhoids characterized by bleeding and pain at evacuation. These patients were examined in a retrospective observational study of 128 patients, 86% of the group. Follow-up varied from 5 up to 72 months with an average observation time of 36.5 months. Success was registered in 90% of patients affected by II-III degree hemorrhoids and the absence of major complications (hemorrhage, incontinence, stenosis, perforation, sepsis). The authors suggest the safety, efficacy and low invasity of HAL Doppler for treatment of II-III degree hemorrhoids, which also found in the literature, and highlight its use in treating patients with unhealthy conditions which are a contraindication to the usual surgical treatments. Moreover, they suppose the use of HAL Doppler in low degree hemorrhoids as a therapeutic and also prophylactic rule of advanced degree.

  3. Effect on the Inhibitory Activity of Potential Microbes on the Complexation of Methyl Anthranilate Derived Hydrazide with Cu, Ni and Zn (II) Metal Ions

    International Nuclear Information System (INIS)

    Ikram, M.; Rehman, S.; Khan, K.

    2013-01-01

    The hydrazide ligand 2-amino-(N-aminobezoyl)benzohydrazide (ABH) have been synthesized and characterized by 1H-NMR, 13C-NMR, ES+-MS, elemental analyses and infrared studies. The ligand was complexed with Ni(II), Cu(II) and Zn(II) metal ions and were characterized by analytical and spectroscopic methods including elemental analyses, ES+-MS, conductance, infrared, UV-Visible and magnetic susceptibilities studies. Infrared spectra show that the ligand form complexes through -NH2 and carbonyl moieties, the elemental studies suggested the M(ABH)X2 composition of the coordination compounds. The synthesized complexes were studied for their biological activities against gram negative bacteria including Escherichia coli, Salmonella typhi, Enterobacter aerogenes, Proteus vulgaris, Pseudomonas aeruginosa, Gram positive bacterial strains like Staphylococcus aureus and fungus like Candida albican. These activities show that the metal complexes are more active to the tested microbes as compared to neat ligand. (author)

  4. Copper(II) complexes of methimazole, an anti Grave's disease drug. Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor.

    Science.gov (United States)

    Urquiza, Nora M; Manca, Silvia G; Moyano, María A; Dellmans, Raquel Arrieta; Lezama, Luis; Rojo, Teófilo; Naso, Luciana G; Williams, Patricia A M; Ferrer, Evelina G

    2010-04-01

    Methimazole (MeimzH) is an anti-thyroid drug and the first choice for patients with Grave's disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)(2)(NO(3))(2)]*0.5H(2)O and [Cu(MeimzH)(2)(H(2)O)(2)](NO(3))(2)*H(2)O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated.

  5. Copper (II)

    African Journals Online (AJOL)

    CLEMENT O BEWAJI

    Valine (2 - amino - 3 – methylbutanoic acid), is a chemical compound containing .... Stability constant (Kf). Gibb's free energy. ) (. 1. −. ∆. Mol. JG. [CuL2(H2O)2] ... synthesis and characterization of Co(ii), Ni(ii), Cu (II), and Zn(ii) complexes with ...

  6. Characterization of monoclonal antibodies against glutamate carboxypeptidase II, the diagnostic and potential therapeutic prostate cancer marker, via the method of surface plasmon resonance

    Czech Academy of Sciences Publication Activity Database

    Tykvart, Jan; Šácha, Pavel; Konvalinka, Jan

    2012-01-01

    Roč. 279, SI suppl. 1 (2012), s. 90-90 ISSN 1742-464X. [IUBMB Congress /22./ and FEBS Congress /37./. 04.09.2012-09.09.2012, Seville] Institutional support: RVO:61388963 Keywords : glutamate carboxypeptidase II Subject RIV: CE - Biochemistry

  7. New modulated design, docking and synthesis of carbohydrate-conjugate heterobimetallic CuII-SnIV complex as potential topoisomerase II inhibitor: in vitro DNA binding, cleavage and cytotoxicity against human cancer cell lines.

    Science.gov (United States)

    Tabassum, Sartaj; Afzal, Mohd; Arjmand, Farukh

    2014-03-03

    New carbohydrate-conjugate heterobimetallic complexes [C₂₂H₅₀N₆O₁₃CuSnCl₂] (3) and [C₂₂H₅₈N₆O₁₇NiSnCl₂] (4) were synthesized from their monometallic analogs [C₂₂H₅₂N₆O₁₃Cu] (1) and [C₂₂H₆₀N₆O₁₇Ni] (2) containing N-glycoside ligand (L). In vitro DNA binding studies of L and complexes (1-4) with CT DNA were carried out by employing various biophysical and molecular docking techniques which revealed that heterobimetallic complex 3 strongly binds to DNA in comparison to 4, monometallic complexes (1 and 2) and the free ligand. Complex 3 cleaves pBR322 DNA via hydrolytic pathway (confirmed by T4 DNA ligase assay) and inhibited Topo-II activity in a dose-dependent manner. Furthermore, complex 3 was docked into the ATPase domain of human-Topo-II in order to probe the possible mechanism of inhibition. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  8. Rhodium (II) cycle alkanecarboxylate: synthesis, spectroscopic and thermo analytic studies and evaluation of the antitumor potential; Cicloalcanocarboxilatos de rodio(II). Sintese, estudos espectroscopicos, termoanaliticos e avaliacao do potencial antitumor

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Aparecido Ribeiro de

    1995-07-01

    Four new rhodium(II) carboxylates (cyclopropane, cyclobutane, cyclopentane, and cyclohexanecarboxylate), and other already known rhodium (II) carboxylates (acetate, propionate, butyrate, metoxyacetate, dichloroacetate, and trifluoroacetate), have been prepared for study in this work. The compounds were characterized by elementary and thermogravimetric analysis, magnetic susceptibility, and electronic, Raman, and infrared spectroscopy. The reaction of Rh CL{sub 3}.aq with the sodium carboxylates was studied aiming to improve the understanding of the redox process involved. Spectroscopy studies (Raman and electronic) were made to examine the transition involved in the Rh-Rh and Rh-O bonds. The results have shown a direct relation between the force of the carboxylic acid and the Rh-O force, but show a inverse relation with the Rh-Rh bond force. Thermal analysis studies were undertaken and the obtained date show a resemblance of the TG/DTG curves with that found in literature. In the other hand, the DSC curves show a different results: in open crucible, the peaks associated with the cage breakdown are exothermic and, in closed crucible this peaks are endothermic. The thermodecomposition products were analyzed. The evolved gases were identified by GC?MS and {sup 1}H and {sup 13} C NMR spectra. The residues were analyzed by X-ray diffraction. Antitumor activity of rhodium cyclopropanecarboxylate was evaluated in vitro (cell cultures K562 and Ehrlich) and in vivo (Balb-c mice with ascite Ehrlich tumor), indicating an increased life span (87.5%) of the treated animals. (author)

  9. Factorization method and new potentials from the inverted oscillator

    International Nuclear Information System (INIS)

    Bermudez, David; Fernández C, David J.

    2013-01-01

    In this article we will apply the first- and second-order supersymmetric quantum mechanics to obtain new exactly-solvable real potentials departing from the inverted oscillator potential. This system has some special properties; in particular, only very specific second-order transformations produce non-singular real potentials. It will be shown that these transformations turn out to be the so-called complex ones. Moreover, we will study the factorization method applied to the inverted oscillator and the algebraic structure of the new Hamiltonians. -- Highlights: •We apply supersymmetric quantum mechanics to the inverted oscillator potential. •The complex second-order transformations allow us to build new non-singular potentials. •The algebraic structure of the initial and final potentials is analyzed. •The initial potential is described by a complex-deformed Heisenberg–Weyl algebra. •The final potentials are described by polynomial Heisenberg algebras

  10. Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease

    OpenAIRE

    Murphy, Caitlin C.; Sanoff, Hanna K.; Stitzenberg, Karyn B.; Baron, John A.; Lund, Jennifer L.; Sandler, Robert S.

    2017-01-01

    Background and Aims. As a first step toward understanding the increasing incidence of colorectal cancer (CRC) in younger (age < 50) populations, we examined demographic, clinicopathologic, and socioeconomic characteristics and treatment receipt in a population-based sample of patients newly diagnosed with stages II and III CRC. Methods. Patients were sampled from the National Cancer Institute's Patterns of Care studies in 1990/91, 1995, 2000, 2005, and 2010 (n = 6, 862). Tumor characteristics...

  11. Potential Contribution of Work-Related Psychosocial Stress to the Development of Cardiovascular Disease and Type II Diabetes: A Brief Review.

    Science.gov (United States)

    Krajnak, Kristine M

    2014-01-01

    Two of the major causes of death worldwide are cardiovascular disease and Type II diabetes. Although death due to these diseases is assessed separately, the physiological process that is attributed to the development of cardiovascular disease can be linked to the development of Type II diabetes and the impact that this disease has on the cardiovascular system. Physiological, genetic, and personal factors contribute to the development of both these disorders. It has also been hypothesized that work-related stress may contribute to the development of Type II diabetes and cardiovascular disease. This review summarizes some of the studies examining the role of work-related stress on the development of these chronic disorders. Because women may be more susceptible to the physiological effects of work-related stress, the papers cited in this review focus on studies that examined the difference in responses of men or women to work-related stress or on studies that focused on the effects of stress on women alone. Based on the papers summarized, it is concluded that (1) work-related stress may directly contribute to the development of cardiovascular disease by inducing increases in blood pressure and changes in heart rate that have negative consequences on functioning of the cardiovascular system; (2) workers reporting increased levels of stress may display an increased risk of Type II diabetes because they adopt poor health habits (ie, increased level of smoking, inactivity etc), which in turn contribute to the development of cardiovascular problems; and (3) women in high demand and low-control occupations report an increased level of stress at work, and thus may be at a greater risk of negative health consequences.

  12. Potential function of added minerals as nucleation sites and effect of humic substances on mineral formation by the nitrate-reducing Fe(II)-oxidizer Acidovorax sp. BoFeN1.

    Science.gov (United States)

    Dippon, Urs; Pantke, Claudia; Porsch, Katharina; Larese-Casanova, Phil; Kappler, Andreas

    2012-06-19

    The mobility of toxic metals and the transformation of organic pollutants in the environment are influenced and in many cases even controlled by iron minerals. Therefore knowing the factors influencing iron mineral formation and transformation by Fe(II)-oxidizing and Fe(III)-reducing bacteria is crucial for understanding the fate of contaminants and for the development of remediation technologies. In this study we followed mineral formation by the nitrate-reducing Fe(II)-oxidizing strain Acidovorax sp. BoFeN1 in the presence of the crystalline Fe(III) (oxyhydr)oxides goethite, magnetite and hematite added as potential nucleation sites. Mössbauer spectroscopy analysis of minerals precipitated by BoFeN1 in (57)Fe(II)-spiked microbial growth medium showed that goethite was formed in the absence of mineral additions as well as in the presence of goethite or hematite. The presence of magnetite minerals during Fe(II) oxidation induced the formation of magnetite in addition to goethite, while the addition of humic substances along with magnetite also led to goethite but no magnetite. This study showed that mineral formation not only depends on the aqueous geochemical conditions but can also be affected by the presence of mineral nucleation sites that initiate precipitation of the same underlying mineral phases.

  13. The analysis of the derivation principles of kinetic equations based on exactly solvable models of the bulk reaction A + B → Product

    International Nuclear Information System (INIS)

    Kipriyanov, A.A.; Doktorov, A.B.

    2005-01-01

    We have considered two many-particle models of the irreversible reaction A + B → Product for which closed kinetic equations for the mean concentration N A (t) of A species can be exactly obtained. These equations are identically recast into a unified form of integro-differential equation of general kinetic theory. It is shown that the memory functions for both models under consideration can be represented as a sum of the Markovian and non-Markovian parts. It is essential that the Markovian part of the Laplace transform of any kernel can be obtained using the Laplace transform of the kernel itself, and is the root of the non-Markovian part of the Laplace transform of the kernel. The properties established allowed us to perform correct approximation of the memory functions at small concentrations [B] of B species and derive the binary non-Markovian integro-differential equation. Within the binary theory accuracy this equation has been rewritten in a regular frame of a familiar rate equation satisfying general principles of binary kinetic equations. Thus using particular exactly solvable many-particle models, we have reproduced the most essential steps of the known general way for the derivation of the binary kinetic equation avoiding the sophisticated many-particle technique and the corresponding approximations. Besides, the results obtained can serve as an additional evidence of the approximations made in a general many-particle approach to the derivation of the binary kinetic equation

  14. Workshop on the role of enhancement of utilization of primary and secondary hydro potential in the context of environmental protection. Part II

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-01

    The publication has been set up as proceedings of the workshop on the role of enhancement of utilization of primary and secondary hydro potential in the context of environmental protection. The proceedings consist of the following chapters: (1) Use of a part and a secondary hydroenergetic potential of the Slovak Republic for electric energy production and its impact on the environment; (2) Economic problems of utilization of hydroenergetic potential of the Slovak Republic and possibilities for their solution; (3) Modernization of control systems of primary and secondary hydro energetic sources of electricity from the point of view of their fulfillment of important functions in operation of a power engineering system in the Slovak Republic; (4) The most important structures utilizing primary and secondary hydroenergetic potential for electric energy production; (5) Progressive technologies, modernization of hydro power projects aimed at rationalization in a use of hydroenergetic potential and environment protection; (6) Possibilities of further utilization of hydroenergetic potential of the Slovak Republic.

  15. Workshop on the role of enhancement of utilization of primary and secondary hydro potential in the context of environmental protection. Part II

    International Nuclear Information System (INIS)

    1997-01-01

    The publication has been set up as proceedings of the workshop on the role of enhancement of utilization of primary and secondary hydro potential in the context of environmental protection. The proceedings consist of the following chapters: (1) Use of a part and a secondary hydroenergetic potential of the Slovak Republic for electric energy production and its impact on the environment; (2) Economic problems of utilization of hydroenergetic potential of the Slovak Republic and possibilities for their solution; (3) Modernization of control systems of primary and secondary hydro energetic sources of electricity from the point of view of their fulfillment of important functions in operation of a power engineering system in the Slovak Republic; (4) The most important structures utilizing primary and secondary hydroenergetic potential for electric energy production; (5) Progressive technologies, modernization of hydro power projects aimed at rationalization in a use of hydroenergetic potential and environment protection; (6) Possibilities of further utilization of hydroenergetic potential of the Slovak Republic

  16. Apolipoprotein C-II Is a Potential Serum Biomarker as a Prognostic Factor of Locally Advanced Cervical Cancer After Chemoradiation Therapy

    International Nuclear Information System (INIS)

    Harima, Yoko; Ikeda, Koshi; Utsunomiya, Keita; Komemushi, Atsushi; Kanno, Shohei; Shiga, Toshiko; Tanigawa, Noboru

    2013-01-01

    Purpose: To determine pretreatment serum protein levels for generally applicable measurement to predict chemoradiation treatment outcomes in patients with locally advanced squamous cell cervical carcinoma (CC). Methods and Materials: In a screening study, measurements were conducted twice. At first, 6 serum samples from CC patients (3 with no evidence of disease [NED] and 3 with cancer-caused death [CD]) and 2 from healthy controls were tested. Next, 12 serum samples from different CC patients (8 NED, 4 CD) and 4 from healthy controls were examined. Subsequently, 28 different CC patients (18 NED, 10 CD) and 9 controls were analyzed in the validation study. Protein chips were treated with the sample sera, and the serum protein pattern was detected by surface-enhanced laser desorption and ionization–time-of-flight mass spectrometry (SELDI-TOF MS). Then, single MS-based peptide mass fingerprinting (PMF) and tandem MS (MS/MS)-based peptide/protein identification methods, were used to identify protein corresponding to the detected peak. And then, turbidimetric assay was used to measure the levels of a protein that indicated the best match with this peptide peak. Results: The same peak 8918 m/z was identified in both screening studies. Neither the screening study nor the validation study had significant differences in the appearance of this peak in the controls and NED. However, the intensity of the peak in CD was significantly lower than that of controls and NED in both pilot studies (P=.02, P=.04) and validation study (P=.01, P=.001). The protein indicated the best match with this peptide peak at 8918 m/z was identified as apolipoprotein C-II (ApoC-II) using PMF and MS/MS methods. Turbidimetric assay showed that the mean serum levels of ApoC-II tended to decrease in CD group when compared with NED group (P=.078). Conclusion: ApoC-II could be used as a biomarker for detection in predicting and estimating the radiation treatment outcome of patients with CC

  17. Apolipoprotein C-II Is a Potential Serum Biomarker as a Prognostic Factor of Locally Advanced Cervical Cancer After Chemoradiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Harima, Yoko, E-mail: harima@takii.kmu.ac.jp [Department of Radiology, Takii Hospital, Kansai Medical University, Moriguchi, Osaka (Japan); Ikeda, Koshi; Utsunomiya, Keita; Komemushi, Atsushi; Kanno, Shohei; Shiga, Toshiko [Department of Radiology, Takii Hospital, Kansai Medical University, Moriguchi, Osaka (Japan); Tanigawa, Noboru [Department of Radiology, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka (Japan)

    2013-12-01

    Purpose: To determine pretreatment serum protein levels for generally applicable measurement to predict chemoradiation treatment outcomes in patients with locally advanced squamous cell cervical carcinoma (CC). Methods and Materials: In a screening study, measurements were conducted twice. At first, 6 serum samples from CC patients (3 with no evidence of disease [NED] and 3 with cancer-caused death [CD]) and 2 from healthy controls were tested. Next, 12 serum samples from different CC patients (8 NED, 4 CD) and 4 from healthy controls were examined. Subsequently, 28 different CC patients (18 NED, 10 CD) and 9 controls were analyzed in the validation study. Protein chips were treated with the sample sera, and the serum protein pattern was detected by surface-enhanced laser desorption and ionization–time-of-flight mass spectrometry (SELDI-TOF MS). Then, single MS-based peptide mass fingerprinting (PMF) and tandem MS (MS/MS)-based peptide/protein identification methods, were used to identify protein corresponding to the detected peak. And then, turbidimetric assay was used to measure the levels of a protein that indicated the best match with this peptide peak. Results: The same peak 8918 m/z was identified in both screening studies. Neither the screening study nor the validation study had significant differences in the appearance of this peak in the controls and NED. However, the intensity of the peak in CD was significantly lower than that of controls and NED in both pilot studies (P=.02, P=.04) and validation study (P=.01, P=.001). The protein indicated the best match with this peptide peak at 8918 m/z was identified as apolipoprotein C-II (ApoC-II) using PMF and MS/MS methods. Turbidimetric assay showed that the mean serum levels of ApoC-II tended to decrease in CD group when compared with NED group (P=.078). Conclusion: ApoC-II could be used as a biomarker for detection in predicting and estimating the radiation treatment outcome of patients with CC.

  18. (II) complexes

    African Journals Online (AJOL)

    activities of Schiff base tin (II) complexes. Neelofar1 ... Conclusion: All synthesized Schiff bases and their Tin (II) complexes showed high antimicrobial and ...... Singh HL. Synthesis and characterization of tin (II) complexes of fluorinated Schiff bases derived from amino acids. Spectrochim Acta Part A: Molec Biomolec.

  19. Potentiated virucidal activity of pomegranate rind extract (PRE and punicalagin against Herpes simplex virus (HSV when co-administered with zinc (II ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV.

    Directory of Open Access Journals (Sweden)

    David M J Houston

    Full Text Available There is a clinical need for new therapeutic products against Herpes simplex virus (HSV. The pomegranate, fruit of the tree Punica granatum L, has since ancient times been linked to activity against infection. This work probed the activity of pomegranate rind extract (PRE and co-administered zinc (II ions.PRE was used in conjunction with zinc (II salts to challenge HSV-1 and aciclovir-resistant HSV in terms of virucidal plaque assay reduction and antiviral activities in epithelial Vero host cells. Cytotoxicity was determined by the MTS assay using a commercial kit.Zinc sulphate, zinc citrate, zinc stearate and zinc gluconate demonstrated similar potentiated virucidal activity with PRE against HSV-1 by up to 4-fold. A generally parabolic relationship was observed when HSV-1 was challenged with PRE and varying concentrations of ZnSO4, with a maximum potentiation factor of 5.5. Punicalagin had 8-fold greater virucidal activity than an equivalent mass of PRE. However, antiviral data showed that punicalagin had significantly lower antiviral activity compared to the activity of PRE (EC50 = 0.56 μg mL-1 a value comparable to aciclovir (EC50 = 0.18 μg mL-1; however, PRE also demonstrated potency against aciclovir-resistant HSV (EC50 = 0.02 μg mL-1, whereas aciclovir showed no activity. Antiviral action of PRE was not influenced by ZnSO4. No cytotoxicity was detected with any test solution.The potentiated virucidal activity of PRE by coadministered zinc (II has potential as a multi-action novel topical therapeutic agent against HSV infections, such as coldsores.

  20. Determination of the potential radiation exposure of the population close to the Asse II mine caused by deduction of radioactive substances with the discharge air in the normal operation using the ''Atmospheric Radionuclide-Transport-Model'' (ARTM)

    International Nuclear Information System (INIS)

    Esch, D.; Wittwer, C.

    2014-01-01

    Between 1967 and 1978 125.787 packages filled with low-level and intermediate-level radioactive waste were emplaced in the mining plant Asse II. Volatile radioactive substances like H-3, C-14 and Rn-222 are released from the emplaced waste. These substances reach the ventilated parts of the mine and are released with the discharge air. The potential radiation exposure of the population caused by deduction of radioactive substances with the discharge air in the normal operation is determined by the ''Atmospheric Radionuclide-Transport-Model'' (ARTM). As result the maximal deductions of volatile radioactive substances with the discharge air in the normal operation of the Asse II mine lead to radiation exposure of the population, which is considerably lower than the permissible values of application rate.

  1. A comprehensive review with potential significance during skull base and neck operations, Part II: glossopharyngeal, vagus, accessory, and hypoglossal nerves and cervical spinal nerves 1-4.

    Science.gov (United States)

    Shoja, Mohammadali M; Oyesiku, Nelson M; Shokouhi, Ghaffar; Griessenauer, Christoph J; Chern, Joshua J; Rizk, Elias B; Loukas, Marios; Miller, Joseph H; Tubbs, R Shane

    2014-01-01

    Knowledge of the possible neural interconnections found between the lower cranial and upper cervical nerves may prove useful to surgeons who operate on the skull base and upper neck regions in order to avoid inadvertent traction or transection. We review the literature regarding the anatomy, function, and clinical implications of the complex neural networks formed by interconnections between the lower cranial and upper cervical nerves. A review of germane anatomic and clinical literature was performed. The review is organized into two parts. Part I discusses the anastomoses between the trigeminal, facial, and vestibulocochlear nerves or their branches and other nerve trunks or branches in the vicinity. Part II deals with the anastomoses between the glossopharyngeal, vagus, accessory and hypoglossal nerves and their branches or between these nerves and the first four cervical spinal nerves; the contribution of the autonomic nervous system to these neural plexuses is also briefly reviewed. Part II is presented in this article. Extensive and variable neural anastomoses exist between the lower cranial nerves and between the upper cervical nerves in such a way that these nerves with their extra-axial communications can be collectively considered a plexus. Copyright © 2013 Wiley Periodicals, Inc.

  2. Duality for heavy-quark systems. II. Coupled channels

    International Nuclear Information System (INIS)

    Durand, B.; Durand, L.

    1981-01-01

    We derive the duality relation approx. = which relates a suitable energy average of the physical coupled-channel cross section sigma=sigma(e + e - →hadrons) to the same average of the cross section sigma/sub bound/ for the production of bound qq-bar states in a single-channel confining potential. The average is equated by our previous work to the average cross section for production of a qq-bar pair moving freely in the nonconfining color Coulomb potential. Thus, approx. = . The corrections to these duality relations are calculable. We give an exactly solvable coupled-two-channel model and use it to verify duality for both weak and strong coupling

  3. The effect of potential on the high-temperature fatigue crack growth response of low alloy steels: Part II, electrochemical results

    International Nuclear Information System (INIS)

    Moshier, W.C.; James, L.A.

    1997-01-01

    Environmentally assisted cracking (EAC) in low alloy steels was found to be dependent on externally applied potential in low sulfur steels in high temperature water. EAC could be turned on when the specimen was polarized anodically above a critical potential. However, hydrogen (H) additions inhibited the ability of potential to affect EAC. The behavior was related to formation of H ions during H oxidation at the crack mouth. A mechanism based on formation of H sulfide at the crack tip and H ions at the crack mouth is presented to describe the process by which sulfides and H ions affect the critical sulfide concentration at the crack tip

  4. Sn(II) oxy-hydroxides as potential adsorbents for Cr(VI)-uptake from drinking water: An X-ray absorption study

    International Nuclear Information System (INIS)

    Pinakidou, Fani; Kaprara, Efthimia; Katsikini, Maria; Paloura, Eleni C.; Simeonidis, Konstantinos; Mitrakas, Manassis

    2016-01-01

    The feasibility of implementing a Sn(II) oxy-hydroxide (Sn_6O_4(OH)_4) for the reduction and adsorption of Cr(VI) in drinking water treatment was investigated using XAFS spectroscopies at the Cr-K-edge. The analysis of the Cr-K-edge XANES and EXAFS spectra verified the effective use of Sn_6O_4(OH)_4 for successful Cr(VI) removal. Adsorption isotherms, as well as dynamic Rapid Small Scale Test (RSSCT) in NSF water matrix showed that Sn_6O_4(OH)_4 can decrease Cr(VI) concentration below the upcoming regulation limit of 10 μg/L for drinking water. Moreover, an uptake capacity of 7.2 μg/mg at breakthrough concentration of 10 μg/L was estimated from the RSSCT, while the residual Cr(VI) concentration ranged at sub-ppb level for a significant period of the experiment. Furthermore, no evidence for the formation of Cr(OH)_3 precipitates was found. On the contrary, Cr(III)-oxyanions were chemisorbed onto SnO_2, which was formed after Sn(II)-oxidation during Cr(VI)-reduction. Nevertheless, changes in the type of Cr(III)-inner sphere complexes were observed after increasing surface coverage: Cr(III)-oxyanions preferentially sorb in a geometry which combines both bidentate binuclear ("2C) and monodentate ("1V) geometries, at the expense of the present bidentate mononuclear ("2E) contributions. On the other hand, the pH during sorption does not affect the adsorption mechanism of Cr(III)-species. The implementation of Sn_6O_4(OH)_4 in water treatment technology combines the advantage of rapidly reducing a large amount of Cr(VI) due to donation of two electrons by Sn(II) and also the strong chemisorption of Cr(III) in a combination of the "2C and "1V configurations, which enhances the safe disposal of spent adsorbents. - Highlights: • Effective Cr(VI) removal from drinking water by Sn_6O_4(OH)_4 • Sn_6O_4(OH)_4 transformation to SnO_2 after Cr(VI) reduction to Cr(III) • Strong Cr(III) sorption onto SnO_2 by formation of inner sphere complexes • Cr(III) sorption

  5. Sn(II) oxy-hydroxides as potential adsorbents for Cr(VI)-uptake from drinking water: An X-ray absorption study.

    Science.gov (United States)

    Pinakidou, Fani; Kaprara, Efthimia; Katsikini, Maria; Paloura, Eleni C; Simeonidis, Konstantinos; Mitrakas, Manassis

    2016-05-01

    The feasibility of implementing a Sn(II) oxy-hydroxide (Sn6O4(OH)4) for the reduction and adsorption of Cr(VI) in drinking water treatment was investigated using XAFS spectroscopies at the Cr-K-edge. The analysis of the Cr-K-edge XANES and EXAFS spectra verified the effective use of Sn6O4(OH)4 for successful Cr(VI) removal. Adsorption isotherms, as well as dynamic Rapid Small Scale Test (RSSCT) in NSF water matrix showed that Sn6O4(OH)4 can decrease Cr(VI) concentration below the upcoming regulation limit of 10μg/L for drinking water. Moreover, an uptake capacity of 7.2μg/mg at breakthrough concentration of 10μg/L was estimated from the RSSCT, while the residual Cr(VI) concentration ranged at sub-ppb level for a significant period of the experiment. Furthermore, no evidence for the formation of Cr(OH)3 precipitates was found. On the contrary, Cr(III)-oxyanions were chemisorbed onto SnO2, which was formed after Sn(II)-oxidation during Cr(VI)-reduction. Nevertheless, changes in the type of Cr(III)-inner sphere complexes were observed after increasing surface coverage: Cr(III)-oxyanions preferentially sorb in a geometry which combines both bidentate binuclear ((2)C) and monodentate ((1)V) geometries, at the expense of the present bidentate mononuclear ((2)E) contributions. On the other hand, the pH during sorption does not affect the adsorption mechanism of Cr(III)-species. The implementation of Sn6O4(OH)4 in water treatment technology combines the advantage of rapidly reducing a large amount of Cr(VI) due to donation of two electrons by Sn(II) and also the strong chemisorption of Cr(III) in a combination of the (2)C and (1)V configurations, which enhances the safe disposal of spent adsorbents. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Development of pyridine-containing macrocyclic copper(II) complexes: potential role in the redox modulation of oxaliplatin toxicity in human breast cells.

    Science.gov (United States)

    Fernandes, Ana S; Costa, Judite; Gaspar, Jorge; Rueff, José; Cabral, M Fátima; Cipriano, Madalena; Castro, Matilde; Oliveira, Nuno G

    2012-09-01

    The unique redox and catalytic chemistry of Cu has justified the development of novel Cu complexes for different therapeutic uses including cancer therapy. In this work, four pyridine-containing aza-macrocyclic copper(II) complexes were prepared (CuL1-CuL4) varying in ring size and/or substituents and their superoxide scavenging activity evaluated. CuL3, the most active superoxide scavenger, was further studied as a modulator of the cytotoxicity of oxaliplatin in epithelial breast MCF10A cells and in MCF7 breast cancer cells. Our results show that CuL3 enhances the therapeutic window of oxaliplatin, by both protecting non-tumour cells and increasing its cytotoxic effect in breast carcinoma cells. CuL3 is thus a promising complex to be further studied and to be used as a lead compound for the optimization of novel chemotherapy sensitizers.

  7. Potential of polyaniline modified clay nanocomposite as a selective decontamination adsorbent for Pb(II) ions from contaminated waters; kinetics and thermodynamic study.

    Science.gov (United States)

    Piri, Somayeh; Zanjani, Zahra Alikhani; Piri, Farideh; Zamani, Abbasali; Yaftian, Mohamadreza; Davari, Mehdi

    2016-01-01

    Nowadays significant attention is to nanocomposite compounds in water cleaning. In this article the synthesis and characterization of conductive polyaniline/clay (PANI/clay) as a hybrid nanocomposite with extended chain conformation and its application for water purification are presented. Clay samples were obtained from the central plain of Abhar region, Abhar, Zanjan Province, Iran. Clay was dried and sieved before used as adsorbent. The conductive polyaniline was inflicted into the layers of clay to fabricate a hybrid material. The structural properties of the fabricated nanocomposite are studied by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM). The elimination process of Pb(II) and Cd(II) ions from synthetics aqueous phase on the surface of PANI/clay as adsorbent were evaluated in batch experiments. Flame atomic absorption instrument spectrophotometer was used for determination of the studied ions concentration. Consequence change of the pH and initial metal amount in aqueous solution, the procedure time and the used adsorbent dose as the effective parameters on the removal efficiency was investigated. Surface characterization was exhibited that the clay layers were flaked in the hybrid nanocomposite. The results show that what happen when a nanocomposite polyaniline chain is inserted between the clay layers. The adsorption of ions confirmed a pH dependency procedure and a maximum removal value was seen at pH 5.0. The adsorption isotherm and the kinetics of the adsorption processes were described by Temkin model and pseudo-second-order equation. Time of procedure, pH and initial ion amount have a severe effect on adsorption efficiency of PANI/clay. By using suggested synthesise method, nano-composite as the adsorbent simply will be prepared. The prepared PANI/clay showed excellent adsorption capability for decontamination of Pb ions from contaminated water. Both of suggested synthesise and

  8. Exploring new potentials and generating hypothesis for management of locally advanced head neck cancer: Analysis of pooled data from two phase II trials

    Directory of Open Access Journals (Sweden)

    Chufal Kundan

    2010-01-01

    Full Text Available Background: To study the long term results of two phase II concurrent chemoradiotherapy protocols and conduct pooled data analysis with special emphasis on nodal density. Materials and Methods: In the period from April 2001 to May 2003, phase II Mitomycin C (MMC and late chemo-intensification (LCI protocols were started in the same institute, enrolling 69 and 74 patients respectively. Long term results for these individual trials are reported along with pooled data analysis. Results: Median follow-up time for whole group, MMC protocol and LCI protocol was 43.8 months (SD619.8, 55 months (SD 618.5 and 47.5 months (SD 620.9 respectively. LRFS, DFS and OS at five years for whole group was 59.4, 43.5 and 47.1% respectively, for MMC protocol was 59.9, 45.5 and 49.5% respectively and for LCI, protocol was 53.6%, 41.5% and 44.4% respectively. Subgroup analysis revealed that MMC protocol was more effective than LCI protocol in terms of DFS and OS in patients with hypo dense nodes while opposite was true for Isodense nodes. Multivariate analysis revealed nodal density as an independent variable that had an impact on treatment outcome. Risk of death in patients with hypo dense nodes was 2.91 times that of Isodense nodes. Conclusions: Innovative and pragmatic approach is required to address locally advanced head neck cancer. Long term results for MMC and LCI protocols are encouraging. Integrating the basic concepts of these protocols may help develop new protocols, which will facilitate the search for the optimal solution.

  9. Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms.

    Directory of Open Access Journals (Sweden)

    Belén Picatoste

    Full Text Available BACKGROUND: Myocardial fibrosis is a key process in diabetic cardiomyopathy. However, their underlying mechanisms have not been elucidated, leading to a lack of therapy. The glucagon-like peptide-1 (GLP-1 enhancer, sitagliptin, reduces hyperglycemia but may also trigger direct effects on the heart. METHODS: Goto-Kakizaki (GK rats developed type-II diabetes and received sitagliptin, an anti-hyperglycemic drug (metformin or vehicle (n=10, each. After cardiac structure and function assessment, plasma and left ventricles were isolated for biochemical studies. Cultured cardiomyocytes and fibroblasts were used for in vitro assays. RESULTS: Untreated GK rats exhibited hyperglycemia, hyperlipidemia, plasma GLP-1 decrease, and cardiac cell-death, hypertrophy, fibrosis and prolonged deceleration time. Moreover, cardiac pro-apoptotic/necrotic, hypertrophic and fibrotic factors were up-regulated. Importantly, both sitagliptin and metformin lessened all these parameters. In cultured cardiomyocytes and cardiac fibroblasts, high-concentration of palmitate or glucose induced cell-death, hypertrophy and fibrosis. Interestingly, GLP-1 and its insulinotropic-inactive metabolite, GLP-1(9-36, alleviated these responses. In addition, despite a specific GLP-1 receptor was only detected in cardiomyocytes, GLP-1 isoforms attenuated the pro-fibrotic expression in cardiomyocytes and fibroblasts. In addition, GLP-1 receptor signalling may be linked to PPARδ activation, and metformin may also exhibit anti-apoptotic/necrotic and anti-fibrotic direct effects in cardiac cells. CONCLUSIONS: Sitagliptin, via GLP-1 stabilization, promoted cardioprotection in type-II diabetic hearts primarily by limiting hyperglycemia e hyperlipidemia. However, GLP-1 and GLP-1(9-36 promoted survival and anti-hypertrophic/fibrotic effects on cultured cardiac cells, suggesting cell-autonomous cardioprotective actions.

  10. Kindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. II. Effects of the NMDA antagonist MK-801.

    LENUS (Irish Health Repository)

    Robinson, G B

    1991-10-18

    The effect of the non-competitive N-methyl-D-aspartate antagonist MK-801 on the early development of kindling-induced potentiation was examined in the rabbit hippocampal dentate gyrus. MK-801 (0.5 mg\\/kg) was administered 2 h before each daily kindling stimulation was applied to the perforant path. This treatment continued for the first 10 days of kindling. MK-801 depressed the growth of the afterdischarge duration and suppressed development of behavioral seizures. MK-801 did not block kindling-induced potentiation of either the perforant path-dentate granule cell population spike or excitatory postsynaptic potential. Random impulse train stimulation and non-linear systems analytic techniques were used to examine kindling-induced potentiation of presumed GABAergic recurrent inhibitory circuits. Both the magnitude and duration of kindling-induced response inhibition, to the second of each pair of impulses within the train, were reduced in rabbits pretreated with MK-801. These results suggest that MK-801 differentially affects kindling-induced potentiation of excitatory and inhibitory circuits within the rabbit hippocampal dentate gyrus.

  11. Sn(II) oxy-hydroxides as potential adsorbents for Cr(VI)-uptake from drinking water: An X-ray absorption study

    Energy Technology Data Exchange (ETDEWEB)

    Pinakidou, Fani; Kaprara, Efthimia [Aristotle University of Thessaloniki, School of Chemical Engineering, Analytical Chemistry Laboratory, 54124 Thessaloniki (Greece); Katsikini, Maria; Paloura, Eleni C.; Simeonidis, Konstantinos [Aristotle University of Thessaloniki, School of Physics, Department of Solid State Physics, 54124 Thessaloniki (Greece); Mitrakas, Manassis, E-mail: manasis@eng.auth.gr [Aristotle University of Thessaloniki, School of Chemical Engineering, Analytical Chemistry Laboratory, 54124 Thessaloniki (Greece)

    2016-05-01

    The feasibility of implementing a Sn(II) oxy-hydroxide (Sn{sub 6}O{sub 4}(OH){sub 4}) for the reduction and adsorption of Cr(VI) in drinking water treatment was investigated using XAFS spectroscopies at the Cr-K-edge. The analysis of the Cr-K-edge XANES and EXAFS spectra verified the effective use of Sn{sub 6}O{sub 4}(OH){sub 4} for successful Cr(VI) removal. Adsorption isotherms, as well as dynamic Rapid Small Scale Test (RSSCT) in NSF water matrix showed that Sn{sub 6}O{sub 4}(OH){sub 4} can decrease Cr(VI) concentration below the upcoming regulation limit of 10 μg/L for drinking water. Moreover, an uptake capacity of 7.2 μg/mg at breakthrough concentration of 10 μg/L was estimated from the RSSCT, while the residual Cr(VI) concentration ranged at sub-ppb level for a significant period of the experiment. Furthermore, no evidence for the formation of Cr(OH){sub 3} precipitates was found. On the contrary, Cr(III)-oxyanions were chemisorbed onto SnO{sub 2}, which was formed after Sn(II)-oxidation during Cr(VI)-reduction. Nevertheless, changes in the type of Cr(III)-inner sphere complexes were observed after increasing surface coverage: Cr(III)-oxyanions preferentially sorb in a geometry which combines both bidentate binuclear ({sup 2}C) and monodentate ({sup 1}V) geometries, at the expense of the present bidentate mononuclear ({sup 2}E) contributions. On the other hand, the pH during sorption does not affect the adsorption mechanism of Cr(III)-species. The implementation of Sn{sub 6}O{sub 4}(OH){sub 4} in water treatment technology combines the advantage of rapidly reducing a large amount of Cr(VI) due to donation of two electrons by Sn(II) and also the strong chemisorption of Cr(III) in a combination of the {sup 2}C and {sup 1}V configurations, which enhances the safe disposal of spent adsorbents. - Highlights: • Effective Cr(VI) removal from drinking water by Sn{sub 6}O{sub 4}(OH){sub 4} • Sn{sub 6}O{sub 4}(OH){sub 4} transformation to SnO{sub 2} after Cr

  12. Historical and current forest landscapes in eastern Oregon and Washington Part II: Linking vegetation characteristics to potential fire behavior and related smoke production.

    Science.gov (United States)

    Mark H. Huff; Roger D. Ottmar; Ernesto Alvarado; Robert E. Vihnanek; John F. Lehmkuhl; Paul F. Hessburg; Richard L. Everett

    1995-01-01

    We compared the potential fire behavior and smoke production of historical and current time periods based on vegetative conditions in forty-nine 5100- to 13 5OO-hectare watersheds in six river basins in eastern Oregon and Washington. Vegetation composition, structure, and patterns were attributed and mapped from aerial photographs taken from 1932 to 1959 (historical)...

  13. The role of binary and many-centre molecular interactions in spin crossover in the solid state. Part II. Non-ideality parameters defined via binary molecular potentials

    International Nuclear Information System (INIS)

    Koudriavtsev, A.B.; Linert, W.

    2005-01-01

    Parameters of the formalism [1-6] describing spin crossover in the solid state have been defined via molecular potentials in model systems of neutral and ionic complexes. In the first instance Lennard-Jones and electric dipole-dipole potentials have been used whereas in ionic systems Lennard-Jones and electric point-charge potentials have been used. Electric dipole-dipole interaction of neutral complexes brings about a positive excess energy controlled by the difference of electric dipole moments of HS and LS molecules. Differences of the order of Δμ = 1-2D cause an abrupt spin crossover in systems with T 1/2 = 100-150K. Magnetic coupling contributes both to the excess energy and excess entropy, however the overall effect is equivalent to a modest positive excess energy. Ionic systems in the absence of specific interactions are characterized by very small excess energies corresponding to practically linear van't Hoff plots. Detectable positive and negative excess energies in these systems may arise from interactions of ligands belonging to neighbouring complexes. The HOMO-LUMO overlap in HS-LS pairs can bring about a nontrivial variation of the shape of transition curves. Examples of regression analysis of experimental transition curves in terms of molecular potentials are given. (author)

  14. Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease

    Directory of Open Access Journals (Sweden)

    Caitlin C. Murphy

    2017-01-01

    Full Text Available Background and Aims. As a first step toward understanding the increasing incidence of colorectal cancer (CRC in younger (age < 50 populations, we examined demographic, clinicopathologic, and socioeconomic characteristics and treatment receipt in a population-based sample of patients newly diagnosed with stages II and III CRC. Methods. Patients were sampled from the National Cancer Institute’s Patterns of Care studies in 1990/91, 1995, 2000, 2005, and 2010 (n=6,862. Tumor characteristics and treatment data were obtained through medical record review and physician verification. We compared sociodemographic and clinicopathologic characteristics and treatment patterns of younger (age < 50 and older (age 50–69, age ≥ 70 CRC patients. Results. Younger patients were more likely to be black (13% and Hispanic (15% than patients aged 50–69 years (11% and 10%, resp. and ≥70 years (7% each. A larger proportion of young white (41% and Hispanic (33% patients had rectal tumors, whereas tumors in the right colon were the most common in young black patients (39%. The majority of younger patients received chemotherapy and radiation therapy, although receipt of microsatellite instability testing was suboptimal (27%. Conclusion. Characteristics of patients diagnosed with young-onset CRC differ considerably by race/ethnicity, with a higher proportion of black and Hispanic patients diagnosed at the age of < 50 years.

  15. Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease.

    Science.gov (United States)

    Murphy, Caitlin C; Sanoff, Hanna K; Stitzenberg, Karyn B; Baron, John A; Lund, Jennifer L; Sandler, Robert S

    2017-01-01

    Background and Aims. As a first step toward understanding the increasing incidence of colorectal cancer (CRC) in younger (age stages II and III CRC. Methods. Patients were sampled from the National Cancer Institute's Patterns of Care studies in 1990/91, 1995, 2000, 2005, and 2010 ( n = 6, 862). Tumor characteristics and treatment data were obtained through medical record review and physician verification. We compared sociodemographic and clinicopathologic characteristics and treatment patterns of younger (age age 50-69, age ≥ 70) CRC patients. Results. Younger patients were more likely to be black (13%) and Hispanic (15%) than patients aged 50-69 years (11% and 10%, resp.) and ≥70 years (7% each). A larger proportion of young white (41%) and Hispanic (33%) patients had rectal tumors, whereas tumors in the right colon were the most common in young black patients (39%). The majority of younger patients received chemotherapy and radiation therapy, although receipt of microsatellite instability testing was suboptimal (27%). Conclusion. Characteristics of patients diagnosed with young-onset CRC differ considerably by race/ethnicity, with a higher proportion of black and Hispanic patients diagnosed at the age of < 50 years.

  16. Experimental and theoretical investigations on Pd(II) host-guest compound: Deciphering the structural and electronic features of a potential bioactive complex

    Science.gov (United States)

    Sreejith, S. S.; Mohan, Nithya; Prathapachandra Kurup, M. R.

    2017-10-01

    A Pd(II) complex from N,N‧-bis(2-hydroxy-3-ethoxybenzylidene)butane-1,4-diamine salen-type ligand has been synthesized and characterised using single crystal XRD analysis, elemental analysis, IR and UV-Vis spectroscopic methods. Thermal profile of the compound is investigated using TG-DTG-DSC method. The quantification of intermolecular interactions and surface morphology has been done using Hirshfeld surface study mapped using various functions like dnorm, shape index and curvedness. ESP analysis is done to visualize the electrophilic and nucleophilic regions in the complex. Geometry optimization of the structure is done using DFT at B3LYP/def2-TZVP level of theory. Frontier orbital analysis reveals the kinetical stability and chemical inertness of the complex. A detailed charge distribution analysis is done using different analytical methods like Mulliken, Löwdin, NPA and AIM methods. Further bond order analysis and topological analysis are also done. Finally the bioactivity of the titled complex is checked using molecular docking method on both DNA and protein.

  17. Potential use of California lignite and other alternate fuel for enhanced oil recovery. Phase I and II. Final report. [As alternative fuels for steam generation in thermal EOR

    Energy Technology Data Exchange (ETDEWEB)

    Shelton, R.; Shimizu, A.; Briggs, A.

    1980-02-01

    The Nation's continued reliance on liquid fossil fuels and decreasing reserves of light oils gives increased impetus to improving the recovery of heavy oil. Thermal enhanced oil recovery EOR techniques, such as steam injection, have generally been the most effective for increasing heavy oil production. However, conventional steam generation consumes a large fraction of the produced oil. The substitution of alternate (solid) fuels would release much of this consumed oil to market. This two-part report focuses on two solid fuels available in California, the site of most thermal EOR - petroleum coke and lignite. Phase I, entitled Economic Analysis, shows detailed cost comparisons between the two candidate fuels and also with Western coal. The analysis includes fuels characterizations, process designs for several combustion systems, and a thorough evaluation of the technical and economic uncertainties. In Phase II, many technical parameters of petroleum coke combustion were measured in a pilot-plant fluidized bed. The results of the study showed that petroleum coke combustion for EOR is feasible and cost effective in a fluidized bed combustor.

  18. Comment on 'Spherical 2+p spin-glass model: An analytically solvable model with a glass-to-glass transition'

    International Nuclear Information System (INIS)

    Krakoviack, V.

    2007-01-01

    Guided by old results on simple mode-coupling models displaying glass-glass transitions, we demonstrate, through a crude analysis of the solution with one step of replica symmetry breaking (1RSB) derived by Crisanti and Leuzzi for the spherical s+p mean-field spin glass [Phys. Rev. B 73, 014412 (2006)], that the phase behavior of these systems is not yet fully understood when s and p are well separated. First, there seems to be a possibility of glass-glass transition scenarios in these systems. Second, we find clear indications that the 1RSB solution cannot be correct in the full glassy phase. Therefore, while the proposed analysis is clearly naive and probably inexact, it definitely calls for a reassessment of the physics of these systems, with the promise of potentially interesting developments in the theory of disordered and complex systems

  19. A new approach to the Schrödinger equation with rational potentials

    Science.gov (United States)

    Dong, Ming-de; Chu, Jue-Hui

    1984-04-01

    A new analytic theory is established for the Schrödinger equation with a rational potential, including a complete classification of the regular eigenfunctions into three different types, an exact method of obtaining wavefunctions, an explicit formulation of the spectral equation (3 x 3 determinant) etc. All representations are exhibited in a unifying way via function-theoretic methods and therefore given in explicit form, in contrast to the prevailing discussion appealing to perturbation or variation methods or continued-fraction techniques. The irregular eigenfunctions at infinity can be obtained analogously and will be discussed separately as another solvable case for singular potentials.

  20. Studies on the mixed ligand complexes of copper(II involving a sulfa drug and some potentially bi or tridentate ligands under physiological conditions

    Directory of Open Access Journals (Sweden)

    S. Regupathy

    2014-12-01

    Full Text Available The stability constants of mixed ligand complexes formed in the Cu(II-sulfathiazole(stz(A-glycine(gly, dl-2-aminobutanoic acid(2aba, dl-3-aminobutanoic acid(3aba, 1,2-diaminopropane(dp, 1,3-diaminopropane(tp, dl-2,3-diaminopropanoic acid(dapa, dl-2,4-diaminobutanoic acid(daba, dl-2,5-diaminopentanoic acid(ornithine, orn(B systems have been determined pH-metrically at 37 °C and I = 0.15 mol dm−3 (NaClO4 using SCOGS program. Analysis of experimental data indicates the presence of CuABH, CuAB, CuAB2H2 or CuAB2 species. The Δlog K values demonstrate higher stabilities for the mixed ligand complexes compared to the binary analogues. The CuAB complexes with B = gly, 2aba, dapa & orn systems were isolated and characterized using micro analytical, magnetic moment, ESR, electrochemical studies, TG/DTA, power XRD and SEM analysis. Magnetic susceptibility and electronic spectral studies suggest square planar geometry for the CuAB complexes. The g values indicate that the unpaired electron lies in thedx2-y2 orbital. The TG/DTA studies reveal that the complexes are non hydrated and possesses high thermal stability. The powder XRD data suggest that the complex is microcrystalline. The antimicrobial activity and CT DNA cleavage studies of the complexes are also reported.

  1. The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy.

    Science.gov (United States)

    Ohsawa, Yutaka; Takayama, Kentaro; Nishimatsu, Shin-ichiro; Okada, Tadashi; Fujino, Masahiro; Fukai, Yuta; Murakami, Tatsufumi; Hagiwara, Hiroki; Itoh, Fumiko; Tsuchida, Kunihiro; Hayashi, Yoshio; Sunada, Yoshihide

    2015-01-01

    Myostatin, a muscle-specific transforming growth factor-β (TGF-β), negatively regulates skeletal muscle mass. The N-terminal prodomain of myostatin noncovalently binds to and suppresses the C-terminal mature domain (ligand) as an inactive circulating complex. However, which region of the myostatin prodomain is required to inhibit the biological activity of myostatin has remained unknown. We identified a 29-amino acid region that inhibited myostatin-induced transcriptional activity by 79% compared with the full-length prodomain. This inhibitory core resides near the N-terminus of the prodomain and includes an α-helix that is evolutionarily conserved among other TGF-β family members, but suppresses activation of myostatin and growth and differentiation factor 11 (GDF11) that share identical membrane receptors. Interestingly, the inhibitory core co-localized and co-immunoprecipitated with not only the ligand, but also its type I and type II membrane receptors. Deletion of the inhibitory core in the full-length prodomain removed all capacity for suppression of myostatin. A synthetic peptide corresponding to the inhibitory core (p29) ameliorates impaired myoblast differentiation induced by myostatin and GDF11, but not activin or TGF-β1. Moreover, intramuscular injection of p29 alleviated muscle atrophy and decreased the absolute force in caveolin 3-deficient limb-girdle muscular dystrophy 1C model mice. The injection suppressed activation of myostatin signaling and restored the decreased numbers of muscle precursor cells caused by caveolin 3 deficiency. Our findings indicate a novel concept for this newly identified inhibitory core of the prodomain of myostatin: that it not only suppresses the ligand, but also prevents two distinct membrane receptors from binding to the ligand. This study provides a strong rationale for the use of p29 in the amelioration of skeletal muscle atrophy in various clinical settings.

  2. In vitro evaluation of the cyto-genotoxic potential of Ruthenium(II) SCAR complexes: a promising class of antituberculosis agents.

    Science.gov (United States)

    De Grandis, Rone Aparecido; Resende, Flávia Aparecida; da Silva, Monize Martins; Pavan, Fernando Rogério; Batista, Alzir Azevedo; Varanda, Eliana Aparecida

    2016-03-01

    Tuberculosis is a top infectious disease killer worldwide, caused by the bacteria Mycobacterium tuberculosis. Increasing incidences of multiple drug-resistance (MDR) strains are emerging as one of the major public health threats. However, the drugs in use are still incapable of controlling the appalling upsurge of MDR. In recent years a marked number of research groups have devoted their attention toward the development of specific and cost-effective antimicrobial agents against targeted MDR-Tuberculosis. In previous studies, ruthenium(II) complexes (SCAR) have shown a promising activity against MDR-Tuberculosis although few studies have indeed considered ruthenium toxicity. Therefore, within the preclinical requirements, we have sought to determine the cyto-genotoxicity of three SCAR complexes in this present study. The treatment with the SCARs induced a concentration-dependent decrease in cell viability in CHO-K1 and HepG2 cells. Based on the clonogenic survival, SCAR 5 was found to be more cytotoxic while SCAR 6 exhibited selectivity action on tumor cells. Although SCAR 4 and 5 did not indicate any mutagenic activity as evidenced by the Ames and Cytokinesis block micronucleus cytome assays, the complex SCAR 6 was found to engender a frameshift mutation detected by Salmonella typhimurium in the presence of S9. Similarly, we observed a chromosomal damage in HepG2 cells with significant increases of micronuclei and nucleoplasmic bridges. These data indicate that SCAR 4 and 5 complexes did not show genotoxicity in our models while SCAR 6 was considered mutagenic. This study presented a comprehensive genotoxic evaluation of SCAR complexes were shown to be genotoxic in vitro. All in all, further studies are required to fully elucidate how the properties can affect human health. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Local state probabilities for solvable restricted solid-on-solid models: A/sub n/, D/sub n/, D/sub n//sup (1)/, and A/sub n//sup (1)/

    International Nuclear Information System (INIS)

    Kuniba, A.; Yajima, T.

    1988-01-01

    The local state probabilities (LSPs) are exactly computed for four hierarchies of solvable lattice models. They are restricted solid-on-solid (RSOS) models whose local states and their adjacent conditions are specified by Dinkin diagrams of types A/sub n/, D/sub n/, D/sub n//sup (1)/ and A/sub n//sup (1)/. The LSPs are expressed in terms of modular functions characterized by branching identities among the theta functions. Their automorphic properties are used to study the critical behaviors. Some fine structures are found in the spectrum of the critical exponents

  4. Translocation and gross deletion breakpoints in human inherited disease and cancer II: Potential involvement of repetitive sequence elements in secondary structure formation between DNA ends.

    Science.gov (United States)

    Chuzhanova, Nadia; Abeysinghe, Shaun S; Krawczak, Michael; Cooper, David N

    2003-09-01

    Translocations and gross deletions are responsible for a significant proportion of both cancer and inherited disease. Although such gene rearrangements are nonuniformly distributed in the human genome, the underlying mutational mechanisms remain unclear. We have studied the potential involvement of various types of repetitive sequence elements in the formation of secondary structure intermediates between the single-stranded DNA ends that recombine during rearrangements. Complexity analysis was used to assess the potential of these ends to form secondary structures, the maximum decrease in complexity consequent to a gross rearrangement being used as an indicator of the type of repeat and the specific DNA ends involved. A total of 175 pairs of deletion/translocation breakpoint junction sequences available from the Gross Rearrangement Breakpoint Database [GRaBD; www.uwcm.ac.uk/uwcm/mg/grabd/grabd.html] were analyzed. Potential secondary structure was noted between the 5' flanking sequence of the first breakpoint and the 3' flanking sequence of the second breakpoint in 49% of rearrangements and between the 5' flanking sequence of the second breakpoint and the 3' flanking sequence of the first breakpoint in 36% of rearrangements. Inverted repeats, inversions of inverted repeats, and symmetric elements were found in association with gross rearrangements at approximately the same frequency. However, inverted repeats and inversions of inverted repeats accounted for the vast majority (83%) of deletions plus small insertions, symmetric elements for one-half of all antigen receptor-mediated translocations, while direct repeats appear only to be involved in mediating simple deletions. These findings extend our understanding of illegitimate recombination by highlighting the importance of secondary structure formation between single-stranded DNA ends at breakpoint junctions. Copyright 2003 Wiley-Liss, Inc.

  5. Nuclear Energy Center Site Survey, 1975. Part II. The U.S. electric power system and the potential role of nuclear energy centers

    International Nuclear Information System (INIS)

    1976-01-01

    Information related to Nuclear Energy Centers (NEC) in the U.S. is presented concerning the U.S. electric power system today; electricity demand history and forecasts; history and forecasts of the electric utility industry; regional notes; the status, history, and forecasts of the nuclear role; power plant siting problems and practices; nuclear facilities siting problems and practices; origin and evolution of the nuclear energy center concept; conceptualized description of nuclear energy centers; potential role of nuclear energy centers; assumptions, criteria, and bases; typical evolution of a nuclear energy center; and the nuclear fuel cycle

  6. Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II-releasing polymer nanoparticles for potential use as a drug delivery vector

    Directory of Open Access Journals (Sweden)

    Harris Alesha

    2011-01-01

    Full Text Available Abstract The field of drug delivery focuses primarily on delivering small organic molecules or DNA/RNA as therapeutics and has largely ignored the potential for delivering catalytically active transition metal ions and complexes. The delivery of a variety of transition metals has potential for inducing apoptosis in targeted cells. The chief aims of this work were the development of a suitable delivery vector for a prototypical transition metal, Cu2+, and demonstration of the ability to impact cancer cell viability via exposure to such a Cu-loaded vector. Carboxylate-functionalized nanoparticles were synthesized by free radical polymerization and were subsequently loaded with Cu2+ via binding to particle-bound carboxylate functional groups. Cu loading and release were characterized via ICP MS, EDX, XPS, and elemental analysis. Results demonstrated that Cu could be loaded in high weight percent (up to 16 wt.% and that Cu was released from the particles in a pH-dependent manner. Metal release was a function of both pH and the presence of competing ligands. The toxicity of the particles was measured in HeLa cells where reductions in cell viability greater than 95% were observed at high Cu loading. The combined pH sensitivity and significant toxicity make this copper delivery vector an excellent candidate for the targeted killing of disease cells when combined with an effective cellular targeting strategy.

  7. Selective attention and the auditory vertex potential. I - Effects of stimulus delivery rate. II - Effects of signal intensity and masking noise

    Science.gov (United States)

    Schwent, V. L.; Hillyard, S. A.; Galambos, R.

    1976-01-01

    The effects of varying the rate of delivery of dichotic tone pip stimuli on selective attention measured by evoked-potential amplitudes and signal detectability scores were studied. The subjects attended to one channel (ear) of tones, ignored the other, and pressed a button whenever occasional targets - tones of a slightly higher pitch were detected in the attended ear. Under separate conditions, randomized interstimulus intervals were short, medium, and long. Another study compared the effects of attention on the N1 component of the auditory evoked potential for tone pips presented alone and when white noise was added to make the tones barely above detectability threshold in a three-channel listening task. Major conclusions are that (1) N1 is enlarged to stimuli in an attended channel only in the short interstimulus interval condition (averaging 350 msec), (2) N1 and P3 are related to different modes of selective attention, and (3) attention selectivity in multichannel listening task is greater when tones are faint and/or difficult to detect.

  8. Gas dispersal potential of infant bedding of sudden death cases (II): Mathematical simulation of O2 deprivation around the face of infant mannequin model.

    Science.gov (United States)

    Sakai, Jun; Takahashi, Shirushi; Funayama, Masato

    2009-04-01

    We assessed O(2) gas deprivation potential of bedding that had actually been used by 26 infants diagnosed with sudden unexpected infant death using FiCO(2) time course of baby mannequin model. All cases were the same ones in our poster paper (I). Mathematically, time-FiCO(2) (t) graphs were given as FiCO(2) (t)=C(1-e(Dt)). Here, "C" approximates the maximum FiCO(2) value, while "D" is the velocity to reach maximum FiCO(2). FiO(2) in a potential space around the mannequin's nares was estimated using a formula: FiO(2)=0.21-FiCO(2)/RQ. RQ is the respiratory quotient, and the normal human value is 0.8. The graph pattern of FiO(2) is roughly the inverse of the FiCO(2) time course. Four cases showed the bottom of estimated FiO(2) to be more than 15%, 15 were 15-6%, and the other seven were 6% or less. Considering the minimal tissue stores of O(2), changes in FiO(2) may be affected by both CO(2) production and gas movement around the infant's face. Especially, the latter seven cases may suggest the participation of the role not only of CO(2) accumulation but also of the decrease of O(2) around the face.

  9. Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes. 15-deoxy-delta(12,14)-prostaglandin j2-induced expression of glutathione S-transferases.

    Science.gov (United States)

    Kawamoto, Y; Nakamura, Y; Naito, Y; Torii, Y; Kumagai, T; Osawa, T; Ohigashi, H; Satoh, K; Imagawa, M; Uchida, K

    2000-04-14

    Exposure of cells to a wide variety of chemoprotective compounds confers resistance to a broad set of carcinogens. For a subset of the chemoprotective compounds, protection is generated by an increase in the abundance of protective enzymes, such as glutathione S-transferases (GSTs). In the present study, we developed a cell culture system that potently responds to phenolic antioxidants and found that antitumor prostaglandins (PGs) are potential inducers of GSTs. We screened primary hepatocytes and multiple cell lines for inducing GST activity upon incubation with the phenolic antioxidant (tert-butylhydroquinone) and found that rat liver epithelial RL34 cells most potently responded. Based on an extensive screening of diverse chemical agents on the induction of GST activity in RL34 cells, the J2 series of PGs, 15-deoxy-Delta(12,14)-prostaglandin J2 (15-deoxy-Delta(12,14)-PGJ2) in particular, were found to be potential inducers of GST. Enhanced gene expression of Class pi GST isozyme (GSTP1) by 15-deoxy-Delta(12,14)-PGJ2 was evident as a drastic elevation of the mRNA level. Hence, we examined the molecular mechanism underlying the 15-deoxy-Delta(12, 14)-PGJ2-induced GSTP1 gene expression. From functional analysis of various deletion mutant genes, we found that the 15-deoxy-Delta(12, 14)-PGJ2 reponse element was localized in a region containing a GSTP1 enhancer I (GPEI) that consists of two imperfect phorbol 12-O-tetradecanoylphorbol-13-acetate response elements. When the GPEI was combined with the minimum GSTP1 promoter, the element indeed showed an enhancer activity in response to 15-deoxy-Delta(12, 14)-PGJ2. Point mutations of either of the two imperfect 12-O-tetradecanoylphorbol-13-acetate response elements in GPEI completely abolished the enhancer activity. Gel mobility shift assays demonstrated that 15-deoxy-Delta(12,14)-PGJ2 specifically stimulated the binding of nuclear proteins including the transcription factor c-Jun, but not Nrf2, to GPEI. These results

  10. Endogenous oscillations of electric potential difference in the cambial region of the pine stem. II. Possible involvement of the oscillations in xylogenesis

    Directory of Open Access Journals (Sweden)

    Wojciech Kurek

    2014-01-01

    Full Text Available Direct and indirect interrelations between xylogenic processes and the endogenous electric potential difference (PD oscillations generated in the cambial region of isolated tissue blocks from pine trunks were investigated. The frequency of transient PD changes varied during the season and displayed three minima which were concurrent with periods of initiation and termination of cambial activity and with the time of transition from early- to late-wood production. The oscillations were damped by TIBA - an inhibitor of polar auxin transport and stimulated by IAA, but only when the hormone was supplied to the apical end of the tissue block. This suggests that the polar transport of auxin may be involved in generation of the transient PD changes. Results of 2-channel recordings in one tissue block suggest that a part of the recorded oscillations (10-25 % exhibit coordination in space and time: a wave-like pattern along the trunk axis is created by PD changes. The pattern might be a physical carrier of information coordinating processes of growth and differentiation in distant parts of the tree.

  11. Prerequisites for biocrops Up-Scaling II: An assessment of the vegetative method of propagation for oilferous plant species with potential for biodiesel production

    International Nuclear Information System (INIS)

    Nyomola, A.M.S.

    2013-01-01

    The rooting ability of hardwood cuttings from six selected non- edible oilferous plant species with potential for biodiesel production namely Telfairia pedata, Jatropha curcas, Excoecaria bussei, Croton macrostachyus, Croton megalocarpus and Ricinus communis was assessed on 4 different potting media i.e. forest top soil, sandy, clay and loamy soil. The proportion of cuttings that rooted were evaluated for the root numbers, root length, root dry weight, sprouting and callus formation. Complete randomized design (CRD) was adopted for the experiments and each of the species was replicated 4 times using 5 hardwood cuttings per plot (5 L capacity pots). An ANOVA was computed to test for the significance of variations between all treatments while Tukey-Kramer Multiple Comparisons test was used to test for the differences between treatment means. Jatropha curcas rooted well both in a non-mist propagator and open nursery pots, Telfairia pedata rooted only in the nursery pots, Excoecaria bussei sprouted in both non-mist propagator and open nursery pots but did not root throughout the entire experimental period of 3 months. Croton macrostachyus, Croton megalocarpus and Ricinus communis neither sprouted nor rooted calling for propagation methods other than using hardwood cuttings. Possibly all Excoecaria bussei cuttings which callused would have eventually differentiated into roots had the experiment been allowed to run for more than 3 months. (author)

  12. Study of hydrogen-molecule guests in type II clathrate hydrates using a force-matched potential model parameterised from ab initio molecular dynamics

    Science.gov (United States)

    Burnham, Christian J.; Futera, Zdenek; English, Niall J.

    2018-03-01

    The force-matching method has been applied to parameterise an empirical potential model for water-water and water-hydrogen intermolecular interactions for use in clathrate-hydrate simulations containing hydrogen guest molecules. The underlying reference simulations constituted ab initio molecular dynamics (AIMD) of clathrate hydrates with various occupations of hydrogen-molecule guests. It is shown that the resultant model is able to reproduce AIMD-derived free-energy curves for the movement of a tagged hydrogen molecule between the water cages that make up the clathrate, thus giving us confidence in the model. Furthermore, with the aid of an umbrella-sampling algorithm, we calculate barrier heights for the force-matched model, yielding the free-energy barrier for a tagged molecule to move between cages. The barrier heights are reasonably large, being on the order of 30 kJ/mol, and are consistent with our previous studies with empirical models [C. J. Burnham and N. J. English, J. Phys. Chem. C 120, 16561 (2016) and C. J. Burnham et al., Phys. Chem. Chem. Phys. 19, 717 (2017)]. Our results are in opposition to the literature, which claims that this system may have very low barrier heights. We also compare results to that using the more ad hoc empirical model of Alavi et al. [J. Chem. Phys. 123, 024507 (2005)] and find that this model does very well when judged against the force-matched and ab initio simulation data.

  13. Cariogenic potential of foods. II. Relationship of food composition, plaque microbial counts, and salivary parameters to caries in the rat model.

    Science.gov (United States)

    Mundorff-Shrestha, S A; Featherstone, J D; Eisenberg, A D; Cowles, E; Curzon, M E; Espeland, M A; Shields, C P

    1994-01-01

    A series of rat caries experiments was carried out to test the relative cariogenic potential and to identify the major carcinogenic elements of 22 popular snack foods. Parameters that were measured included rat caries, number of cariogenic bacteria in plaque, salivary parameters including flow rate, buffering capacity, total protein, lysozyme and amylase content, and composition of test foods including protein, fat, phosphorus, calcium, fluoride, galactose, glucose, total reducing sugar, sucrose, and starch. Many interesting relationships were observed between food components, numbers of plaque bacteria, salivary components, and specific types of carious lesions. Protein, fat, and phosphorus in foods were all associated with inhibition of both sulcal and buccolingual (smooth-surface) caries. Food fluoride was associated with inhibition of buccolingual caries, whereas calcium was related to inhibition of sulcal caries. Glucose, reducing sugar, and sucrose in foods were all related to promotion of both sulcal and smooth-surface caries. The numbers of Streptococcus sobrinus in plaque were associated with promotion of smooth-surface caries only, whereas lactobacilli, non-mutans bacteria, and total viable flora were related to promotion of both smooth-surface and sulcal caries. The salivary flow rate was associated with inhibition of both buccolingual and sulcal caries. Salivary buffering capacity (at pH 7) and salivary lysozyme delivery were associated with inhibition of number and severity of sulcal caries, while the salivary amylase content was related to the promotion of the number of sulcal lesions.

  14. An estimation of impact of anthropogenic aerosols in atmosphere of Tirana on solar insolation. Part II: Modification of solar energy potential

    Energy Technology Data Exchange (ETDEWEB)

    Buzra, Urim, E-mail: rimibuzra@yahoo.com; Berberi, Pellumb; Mitrushi, Driada; Muda, Valbona [Department of Engineering Physics, FIMIF, PUT, Tirana (Albania); Halili, Daniela [Department of physics, FNS, AXHU, Elbasan (Albania); Berdufi, Irma [Institute of Nuclear Physics, INP, TU, Tirana (Albania)

    2016-03-25

    Change of irradiative properties of the atmosphere during clear days is an indicator, among others, of existence of atmospheric aerosols and can be used as an indicator for assessment both air pollution and local modifications of solar energy potentials. The main objective of this study is estimation of influence of anthropogenic aerosols on solar energy falling in a horizontal surface during a cloudless day. We have analyzed and quantified the effect of aerosols on reducing the amount of solar energy that falls on the horizontal ground surface in cloudless sky conditions, estimating temporal evolution, both in daily and hour scale, considering also, side effects caused by relative humidity of the air wind speed and geometric factor. As an indicator of concentration of aerosols in atmosphere, we agreed to use the attenuation of solar radiation after the last rainy day. All data were corrected by factors such as, variations of relative humidity, wind speed and daily change of incident angle of solar radiation. We studied the change of solar insolation in three sites with different traffic intensity, one in city of Shkodra and two in city of Tirana. Fifteen days after last rainy day, approximate time needed to achieve saturation, the insolation drops only 3.1% in the city of Shkodra, while in two sites in city of Tirana are 8.5 % and 18.4%. These data show that reduction of solar insolation is closely related with anthropogenic activity, mainly traffic around the site of the meteorological station. The day to day difference tends to decrease with increasing of number of days passed from the last rainy day, which is an evidence of a trend toward a dynamic equilibrium between decantation process of aerosols during the night and their generation during the day.

  15. Thermal and chemical evolution in the early Solar System as recorded by FUN CAIs: Part II - Laboratory evaporation of potential CMS-1 precursor material

    Science.gov (United States)

    Mendybaev, Ruslan A.; Williams, Curtis D.; Spicuzza, Michael J.; Richter, Frank M.; Valley, John W.; Fedkin, Alexei V.; Wadhwa, Meenakshi

    2017-03-01

    We present the results of laboratory experiments in which a forsterite-rich melt estimated to be a potential precursor of Allende CMS-1 FUN CAI was evaporated into vacuum for different lengths of time at 1900 °C. The evaporation of this melt resulted in residues that define trajectories in chemical as well as magnesium, silicon and oxygen isotopic composition space and come very close to the measured properties of CMS-1. The isotopic composition of the evaporation residues was also used to determine the kinetic isotopic fractionation factors [α2,1 (vapor-melt) defined as the ratio of isotopes 2 and 1 of a given element in the evaporating gas divided by their ratio in the evaporating source] for evaporation of magnesium (α25,24 for 25Mg/24Mg), silicon (α29,28 for 29Si/28Si) and oxygen (α18,16 for 18O/16O) from the forsterite-rich melt at 1900 °C. The values of α25,24 = 0.98383 ± 0.00033 and α29,28 = 0.99010 ± 0.00038 are essentially independent of change in the melt composition as evaporation proceeds. In contrast, α18,16 changes from 0.9815 ± 0.0016 to ∼0.9911 when the residual melt composition changes from forsteritic to melilitic. Using the determined values of α25,24 and α29,28 and present-day bulk chemical composition of the CMS-1, the composition of the precursor of the inclusion was estimated to be close to the clinopyroxene + spinel + forsterite assemblage condensed from a solar composition gas. The correspondence between the chemical composition and isotopic fractionation of experimental evaporation residues and the present-day bulk chemical and isotopic compositions of CMS-1 is evidence that evaporation played a major role in the chemical evolution of CMS-1.

  16. Electrostatic control by lipids upon the membrane-bound (Na+ + K+)-ATPase. II. The influence of surface potential upon the activating ion equilibria.

    Science.gov (United States)

    Ahrens, M L

    1983-07-13

    Electrostatic influences upon the enzymatic activity of the (Na+ + K+)-ATPase from ox brain (EC 3.6.1.3) have been studied. (1) The characteristics of the temperature dependence of the activity - the slopes and inflection temperature, Ti, of the Arrhenius plots - have been shown to depend on the total concentration, but not on the specific properties of added monovalent ions. (2) The enzymatic activity has been shown to be subject simultaneously to unspecific and specific influences of alkali-metal ions or NH+4. Ion-specific effects result from different binding constants of complexation between activating ions and enzyme. These stability constants are affected by the formation of an electrical double layer at the membrane surface. With increasing electrostatic screening, the complex formation is destabilized and, as a consequence, the enzymatic activity decreases. (3) This interaction between ion binding and surface electrostatics enables the enzyme to adapt its activity to the actual ionic conditions. This gives rise to a complex net dependence of the enzymatic activity upon the concentrations of activating ions. Such dependencies are analyzed, and an 'activity surface' has been constructed which represents the enzymatic activity as a function of simultaneously varying concentrations of sodium and potassium. The shape of this activity surface is determined by the relations between ion concentrations, surface potential and the resulting stability of the complexation between the activating ions and the enzyme. By means of three-dimensional representation it is demonstrated that the adaptability of the stability constants is of great importance with respect to the maintenance of the optimal ionic concentrations within the living cell. Therefore, by means of the surrounding membrane, the ATPase is provided with a quality, in addition to its substrate specificity and catalytic ability, which is necessary for its function as a transport enzyme.

  17. Short-rotation forestry of birch, maple, poplar and willow in Flanders (Belgium) II. Energy production and CO2 emission reduction potential

    International Nuclear Information System (INIS)

    Walle, Inge van de; Camp, Nancy van; Casteele, Liesbet van de; Verheyen, Kris; Lemeur, Raoul

    2007-01-01

    Belgium, being an EU country, has committed itself to a 7.5% reduction of greenhouse gas emissions during the first commitment period of the Kyoto Protocol. Within this framework, the Flemish government aims at reaching a share of 6% of renewable electricity in the total electricity production by 2010. In this work, the biomass production of birch, maple, poplar and willow in a short-rotation forestry (SRF) plantation after a 4-year growth period served as the base to calculate the amount of (electrical) energy that could be produced by this type of bioenergy crop in Flanders. The maximum amount of electricity that could be provided by SRF biomass was estimated at 72.9 GWh e year -1 , which only accounts for 0.16% of the total electricity production in this region. Although the energy output was rather low, the bioenergy production process under consideration appeared to be more energy efficient than energy production processes based on fossil fuels. The high efficiency of birch compared to the other species was mainly due to the high calorific value of the birch wood. The maximum CO 2 emission reduction potential of SRF plantations in Flanders was estimated at only 0.09% of the total annual CO 2 emission. The most interesting application of SRF in Flanders seemed to be the establishment of small-scale plantations, linked to a local combined heat and power plant. These plantations could be established on marginal arable soils or on polluted sites, and they could be of importance in the densely populated area of Flanders because of other environmental benefits, among which their function as (temporary) habitat for many species

  18. TJ-II project

    International Nuclear Information System (INIS)

    Alejaldre, C.; Gozalo, J.J.A.; Perez, J.B.; Magaria, F.C.; Diaz, J.R.C.; Perez, J.G.; Lopez-Fraguas, A.; Garcia, L.; Krivenski, V.I.; Martin, R.; Navarro, A.P.; Perea, A.; Rodriguez-Yunta, A.; Ayza, M.S.; Varias, A.

    1990-01-01

    The TJ-II device is a medium-size helical-axis stellarator to be built in Madrid. Its main characteristics are potential for high-beta operation; flexibility, i.e., its rotational transform can be varied over a wide range and its shear to some extent; and bean-shaped plasma cross section. The latest understanding of TJ-II physics in the fields of electron cyclotron resonance heating, transport, and magneto-hydrodynamics, and the engineering solutions introduced in its final design are discussed

  19. Galaxy S II

    CERN Document Server

    Gralla, Preston

    2011-01-01

    Unlock the potential of Samsung's outstanding smartphone with this jargon-free guide from technology guru Preston Gralla. You'll quickly learn how to shoot high-res photos and HD video, keep your schedule, stay in touch, and enjoy your favorite media. Every page is packed with illustrations and valuable advice to help you get the most from the smartest phone in town. The important stuff you need to know: Get dialed in. Learn your way around the Galaxy S II's calling and texting features.Go online. Browse the Web, manage email, and download apps with Galaxy S II's 3G/4G network (or create you

  20. TBscore II

    DEFF Research Database (Denmark)

    Rudolf, Frauke; Lemvik, Grethe; Abate, Ebba

    2013-01-01

    Abstract Background: The TBscore, based on simple signs and symptoms, was introduced to predict unsuccessful outcome in tuberculosis patients on treatment. A recent inter-observer variation study showed profound variation in some variables. Further, some variables depend on a physician assessing...... them, making the score less applicable. The aim of the present study was to simplify the TBscore. Methods: Inter-observer variation assessment and exploratory factor analysis were combined to develop a simplified score, the TBscore II. To validate TBscore II we assessed the association between start...

  1. Synthesis, α-glucosidase inhibitory activity and in silico study of tris-indole hybrid scaffold with oxadiazole ring: As potential leads for the management of type-II diabetes mellitus.

    Science.gov (United States)

    Taha, Muhammad; Rahim, Fazal; Imran, Syahrul; Ismail, Nor Hadiani; Ullah, Hayat; Selvaraj, Manikandan; Javid, Muhammad Tariq; Salar, Uzma; Ali, Muhammad; Khan, Khalid Mohammed

    2017-10-01

    Discovery of α-glucosidase inhibitors has been actively pursued with the aim to develop therapeutics for the treatment of type-II diabetes mellitus and the other carbohydrate mediated disease. In continuation of our drug discovery research on potential antidiabetic agents, we synthesized novel tris-indole-oxadiazole hybrid analogs (1-21), structurally characterized by various spectroscopic techniques such as 1 H NMR, EI-MS, and 13 C NMR. Elemental analysis was found in agreement with the calculated values. All compounds were evaluated for α-glucosidase inhibiting potential and showed potent inhibitory activity in the range of IC 50 =2.00±0.01-292.40±3.16μM as compared to standard acarbose (IC 50 =895.09±2.04µM). The pharmacokinetic predictions of tris-indole series using descriptor properties showed that almost all compounds in this series indicate the drug aptness. Detailed binding mode analyses with docking simulation was also carried out which showed that the inhibitors can be stabilized by the formation of hydrogen bonds with catalytic residues and the establishment of hydrophobic contacts at the opposite side of the active site. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. A High Molar Extinction Coefficient Ru(II Complex Functionalized with cis-Dithiocyanato-bis-(9-anthracenyl-10-(2-methyl-2-butenoic acid-1,10-phenanthroline: Potential Sensitizer for Stable Dye-Sensitized Solar Cells

    Directory of Open Access Journals (Sweden)

    Adewale O. Adeloye

    2014-01-01

    Full Text Available New heteroleptic ruthenium(II complex was formulated as [Ru(L12(NCS2], where L1 = 9-anthracenyl-10-(2-methyl-2-butenoic acid-1,10-phenanthroline was synthesized and its photophysical properties were studied and compared to previously reported analogue complex containing no anthracene moiety [Ru(L22(NCS2], L2 = (2-methyl-2-butenoic acid-1,10-phenanthroline. The two complexes though exhibit very strong molar extinction coefficient values; however, [Ru(L12(NCS2] shows better characteristic broad and intense metal-to-ligand charge transfer (MLCT absorption band and higher molar absorptivity coefficient at (λmax=522 nm, ε=6.60×104 M−1 cm−1 than that of [Ru(L22(NCS2] complex, (λmax=446 nm, ε=4.82×104 M−1 cm−1. At room temperature, long wavelength emissions with strong intensity ratio centered at 660 nm were recorded for [Ru(L12(NCS2] complex with a bathochromic shift (λem=700 nm for [Ru(L22(NCS2] complex. It was shown that the luminescence wavelength characteristic of the complexes may be a function relating to the increasing length of π-conjugation and/or molecular weight. A preliminary cyclic voltammetry of [Ru(L12(NCS2] complex also exhibits good electroredox activity with oxidation potential of about 1.04 V, significantly better than other Ru(II polypyridine complexes containing bidentate ligands.

  3. Pb II

    African Journals Online (AJOL)

    Windows User

    This investigation describes the use of non-living biomass of Aspergillus caespitosus for removal of ... Pb(II) production has exceeded 3.5 million tons per year. It has been used in the ... This biomass was selected after screening a wide range of microbes. .... prolonged, which proved better biopolymer in metal uptake (Gadd ...

  4. ISLSCP II Potential Natural Vegetation Cover

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: This data set was developed to describe the state of the global land cover in terms of 15 major vegetation types, plus water, before alteration by humans....

  5. High-spin level structure and Ground-state phase transition in the odd-mass 103-109Rh isotopes in the framework of exactly solvable sdg interacting boson-fermion model

    Science.gov (United States)

    Ghapanvari, M.; Ghorashi, A. H.; Ranjbar, Z.; Jafarizadeh, M. A.

    2018-03-01

    In this article, the negative-parity states in the odd-mass 103 - 109Rh isotopes in terms of the sd and sdg interacting-boson fermion models were studied. The transitional interacting boson-fermion model Hamiltonians in sd and sdg-IBFM versions based on affine SU (1 , 1) Lie Algebra were employed to describe the evolution from the spherical to deformed gamma unstable shapes along with the chain of Rh isotopes. In this method, sdg-IBFM Hamiltonian, which is a three level pairing Hamiltonian was determined easily via the exactly solvable method. Some observables of the shape phase transitions such as energy levels, the two neutron separation energies, signature splitting of the γ-vibrational band, the α-decay and double β--decay energies were calculated and examined for these isotopes. The present calculation correctly reproduces the spherical to gamma-soft phase transition in the Rh isotopes. Some comparisons were made with sd-IBFM.

  6. Estimation of the chemical-induced eye injury using a Weight-of-Evidence (WoE) battery of 21 artificial neural network (ANN) c-QSAR models (QSAR-21): part II: corrosion potential.

    Science.gov (United States)

    Verma, Rajeshwar P; Matthews, Edwin J

    2015-03-01

    This is part II of an in silico investigation of chemical-induced eye injury that was conducted at FDA's CFSAN. Serious eye damage caused by chemical (eye corrosion) is assessed using the rabbit Draize test, and this endpoint is an essential part of hazard identification and labeling of industrial and consumer products to ensure occupational and consumer safety. There is an urgent need to develop an alternative to the Draize test because EU's 7th amendment to the Cosmetic Directive (EC, 2003; 76/768/EEC) and recast Regulation now bans animal testing on all cosmetic product ingredients and EU's REACH Program limits animal testing for chemicals in commerce. Although in silico methods have been reported for eye irritation (reversible damage), QSARs specific for eye corrosion (irreversible damage) have not been published. This report describes the development of 21 ANN c-QSAR models (QSAR-21) for assessing eye corrosion potential of chemicals using a large and diverse CFSAN data set of 504 chemicals, ADMET Predictor's three sensitivity analyses and ANNE classification functionalities with 20% test set selection from seven different methods. QSAR-21 models were internally and externally validated and exhibited high predictive performance: average statistics for the training, verification, and external test sets of these models were 96/96/94% sensitivity and 91/91/90% specificity. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Small Diameter Bomb Increment II (SDB II)

    Science.gov (United States)

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-439 Small Diameter Bomb Increment II (SDB II) As of FY 2017 President’s Budget Defense... Bomb Increment II (SDB II) DoD Component Air Force Joint Participants Department of the Navy Responsible Office References SAR Baseline (Production...Mission and Description Small Diameter Bomb Increment II (SDB II) is a joint interest United States Air Force (USAF) and Department of the Navy

  8. A limit of the confluent Heun equation and the Schroedinger equation for an inverted potential and for an electric dipole

    International Nuclear Information System (INIS)

    El-Jaick, Lea Jaccoud; Figueiredo, Bartolomeu D.B.

    2009-01-01

    We reexamine and extend a group of solutions in series of Bessel functions for a limiting case of the confluent Heun equation and, then, apply such solutions to the one-dimensional Schroedinger equation with an inverted quasi-exactly solvable potential as well as to the angular equation for an electron in the field of a point electric dipole. For the first problem we find finite and infinite-series solutions which are convergent and bounded for any value of the independent variable. For the angular equation, we also find expansions in series of Jacobi polynomials. (author)

  9. Assessment of Correlation Between Early and Late Efficacy Endpoints to Identify Potential Surrogacy Relationships in Non-Hodgkin Lymphoma: a Literature-Based Meta-analysis of 108 Phase II and Phase III Studies.

    Science.gov (United States)

    Zhu, Rui; Lu, Dan; Chu, Yu-Waye; Chai, Akiko; Green, Michelle; Zhang, Nancy; Jin, Jin Yan

    2017-05-01

    Correlations between early and late efficacy endpoints were assessed to identify potential surrogate endpoints for overall survival (OS) or progression-free survival (PFS) with clinical trial-level data in three non-Hodgkin lymphoma (NHL) subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and mantle cell lymphoma (MCL). One hundred and eight phase II-III trials (129 trial arms) in DLBCL, FL, and MCL were identified and included in the database. Correlations between efficacy endpoints were analyzed using weighted linear regression and Pearson's coefficient of determination (R 2 ). In newly diagnosed DLBCL, 6-month PFS was strongly correlated with 2-year OS (R 2  = 0.81, 95% confidence interval [CI] 0.51-0.96). Six-month PFS was strongly correlated with 3-year PFS (R 2  = 0.89, 95% CI 0.62-0.96) in FL and was moderately correlated with 2-year OS (R 2  = 0.69, 95% CI 0.40-0.91) in MCL trials. Linear regression determined that a 10% increase in 6-month PFS would yield a 13% ± 1.2% increase in 2-year OS in DLBCL, a 23% ± 1.1% increase in 3-year PFS in FL, or a 6.7% ± 1.0% increase in 2-year OS in MCL. Both 6-month PFS and complete response (CR) rate were moderately correlated with median PFS in FL trials with R 2  = 0.66 (95% CI 0.52-0.98) and R 2  = 0.69 (95% CI 0.22-0.89), respectively. Six-month PFS is a potential surrogate endpoint for 2-year OS in newly diagnosed DLBCL and MCL and for 3-year PFS in FL. Both 6-month PFS and CR rate are potential surrogate endpoints for median PFS in FL patients. Confirmation and validation of these correlations may facilitate early interpretation of NHL trials.

  10. Exact wavefunctions for a time-dependent Coulomb potential

    International Nuclear Information System (INIS)

    Menouar, S; Maamache, M; Saadi, Y; Choi, J R

    2008-01-01

    The one-dimensional Schroedinger equation associated with a time-dependent Coulomb potential is studied. The invariant operator method (Lewis and Riesenfeld) and unitary transformation approach are employed to derive quantum solutions of the system. We obtain an ordinary second-order differential equation whose analytical exact solution has been unknown. It is confirmed that the form of this equation is similar to the radial Schroedinger equation for the hydrogen atom in a (arbitrary) strong magnetic field. The qualitative properties for the eigenstates spectrum are described separately for the different values of the parameter ω 0 appearing in the x 2 term, x being the position, i.e., ω 0 > 0, ω 0 0 = 0. For the ω 0 = 0 case, the eigenvalue equation of invariant operator reduces to a solvable form and, consequently, we have provided exact eigenstates of the time-dependent Hamiltonian system

  11. Part I. Application of pulse polarography and pulse anodic stripping to the determination of selected heavy metals in natural waters. Part II. Application of controlled potential coulometric techniques to the determination of uranium

    International Nuclear Information System (INIS)

    Crosmun, S.T.

    1977-06-01

    The use of a thin mercury film wax-impregnated graphite electrode for the simultaneous determination of cadmium, lead and zinc in an acetate buffer by differential pulse anodic stripping voltammetry is described. Optimal instrumental parameters for maximum resolution and sensitivity for simultaneous analysis of these three elements in natural waters are discussed. The interference of copper with the determination of zinc is investigated in detail. An optimal mercury film thickness for this electrode is suggested. A method utilizing differential pulse polarography for the determination of chromium (VI) in natural water is described. Additions of 0.62 μg Cu(II) ml -1 and 0.55 μg Fe(III) ml -1 did not interfere with the determination of 0.050 μg Cr(VI) ml -1 . The natural water samples containing Cr(VI) were buffered to approximately pH 7 with 0.1 M ammonium acetate and 0.005 M ethylenediamine and analyzed. Natural water samples of chromium from 0.035 μg to 2.0 μg.ml -1 may be analyzed directly without further preparation. The detection limit is 0.010 μg.ml -1 . A novel, highly efficient cell with integral stirrer for controlled potential coulometry is described. This cell was used to demonstrate the feasibility of determining uranium (VI) by predictive coulometry. A PDP 8/I minicomputer was used to predict the coulometric endpoint with high accuracy within 2.5 minutes in a titration which normally takes about 10 minutes. This technique was shown to yield acceptable results even in the presence of an interfering phosphate matrix

  12. Tomo II

    OpenAIRE

    Llano Zapata, José Eusebio

    2015-01-01

    Memorias, histórico, físicas, crítico, apologéticas de la América Meridional con unas breves advertencias y noticias útiles, a los que de orden de Su Majestad hubiesen de viajar y describir aquellas vastas regiones. Reino Vegetal, Tomo II. Por un anónimo americano en Cádiz por los años de 1757. Muy Señor mío, juzgo que los 20 artículos del libro que remití a Vuestra Merced le habrán hecho formar el concepto que merece la fecundidad de aquellos países en las producciones minerales. Y siendo es...

  13. Determination of the potential radiation exposure of the population close to the Asse II mine caused by deduction of radioactive substances with the discharge air in the normal operation using the ''Atmospheric Radionuclide-Transport-Model'' (ARTM); Ermittlung der potenziellen Strahlenexposition der Bevoelkerung in der Umgebung der Schachtanlage Asse II infolge Ableitung radioaktiver Stoffe mit den abwettern im bestimmungsgemaessen Betrieb mittels des ''atmospaerischen Radionuklid-Transport-Modells'' ARTM

    Energy Technology Data Exchange (ETDEWEB)

    Esch, D.; Wittwer, C. [Bundesamt fuer Strahlenschutz, Salzgitter (Germany)

    2014-01-20

    Between 1967 and 1978 125.787 packages filled with low-level and intermediate-level radioactive waste were emplaced in the mining plant Asse II. Volatile radioactive substances like H-3, C-14 and Rn-222 are released from the emplaced waste. These substances reach the ventilated parts of the mine and are released with the discharge air. The potential radiation exposure of the population caused by deduction of radioactive substances with the discharge air in the normal operation is determined by the ''Atmospheric Radionuclide-Transport-Model'' (ARTM). As result the maximal deductions of volatile radioactive substances with the discharge air in the normal operation of the Asse II mine lead to radiation exposure of the population, which is considerably lower than the permissible values of application rate.

  14. Interactions of Nickel(II) with histones: interactions of Nickel(II) with CH3CO-Thr-Glu-Ser-His-His-Lys-NH2, a peptide modeling the potential metal binding site in the "C-Tail" region of histone H2A.

    Science.gov (United States)

    Bal, W; Lukszo, J; Bialkowski, K; Kasprzak, K S

    1998-09-01

    A combined pH-metric and spectroscopic (UV/vis, CD, NMR) study of the Ni(II) binding to CH3CO-Thr-Glu-Ser-His-His-Lys-NH2 (AcTESHHKam), a blocked hexapeptide modeling a part of the C-terminal sequence of the major variant of histone H2A (residues 120-125), revealed the formation of a pseudo-octahedral NiHL complex in weakly acidic and neutral solutions. Ni(II) is bound to the peptide through imidazole nitrogens on both of its histidine residues and the carboxylate of the side chain of glutamic acid. At higher pH, a series of square-planar complexes are formed. This process is accompanied by hydrolytic degradation of the peptide. At pH 7.4, the peptide hydrolyzes in a Ni(II)-assisted fashion, yielding the square-planar Ni(II) complex of SHHKam as the sole product detected by CD, MALDI-TOF MS, and HPLC. Quantitative analysis of complex stabilities indicates that the -TESHHK- motif is a very likely binding site for carcinogenic Ni(II) ions in the cell nucleus. The Ni(II)-assisted hydrolysis of the C-terminal chain of histone H2A may provide a novel mechanism of genotoxicity combining the damage to the nucleosome with the generation of further toxic Ni(II) species.

  15. Physics II for dummies

    CERN Document Server

    Holzner, Steven

    2010-01-01

    A plain-English guide to advanced physics. Does just thinking about the laws of motion make your head spin? Does studying electricity short your circuits? Physics II For Dummies walks you through the essentials and gives you easy-to-understand and digestible guidance on this often intimidating course. Thanks to this book, you don?t have to be Einstein to understand physics. As you learn about mechanical waves and sound, forces and fields, electric potential and electric energy, and much more, you?ll appreciate the For Dummies law: The easier we make it, the faster you'll understand it!

  16. Cd(II), Cu(II)

    African Journals Online (AJOL)

    user

    Depending on the way goethite was pretreated with oxalic acid, affinity for Cd(II) varied ...... Effects and mechanisms of oxalate on Cd(II) adsorption on goethite at different ... precipitation, surfactant mediation, hydrothermal and micro-emulsion.

  17. Cu(II) AND Zn(II)

    African Journals Online (AJOL)

    Preferred Customer

    SYNTHESIS OF 2,2-DIMETHYL-4-PHENYL-[1,3]-DIOXOLANE USING ZEOLITE. ENCAPSULATED Co(II), Cu(II) AND Zn(II) COMPLEXES. B.P. Nethravathi1, K. Rama Krishna Reddy2 and K.N. Mahendra1*. 1Department of Chemistry, Bangalore University, Bangalore-560001, India. 2Department of Chemistry, Government ...

  18. Elizabeth II uus kunstigalerii

    Index Scriptorium Estoniae

    1999-01-01

    Tähistamaks oma troonile asumise 50. aastapäeva, avab Elizabeth II 6. II 2002 Buckinghami palees uue kunstigalerii, mis ehitatakse palee tiibhoonena. Arhitekt John Simpson. Elizabeth II kunstikogust

  19. Shark class II invariant chain reveals ancient conserved relationships with cathepsins and MHC class II.

    Science.gov (United States)

    Criscitiello, Michael F; Ohta, Yuko; Graham, Matthew D; Eubanks, Jeannine O; Chen, Patricia L; Flajnik, Martin F

    2012-03-01

    The invariant chain (Ii) is the critical third chain required for the MHC class II heterodimer to be properly guided through the cell, loaded with peptide, and expressed on the surface of antigen presenting cells. Here, we report the isolation of the nurse shark Ii gene, and the comparative analysis of Ii splice variants, expression, genomic organization, predicted structure, and function throughout vertebrate evolution. Alternative splicing to yield Ii with and without the putative protease-protective, thyroglobulin-like domain is as ancient as the MHC-based adaptive immune system, as our analyses in shark and lizard further show conservation of this mechanism in all vertebrate classes except bony fish. Remarkable coordinate expression of Ii and class II was found in shark tissues. Conserved Ii residues and cathepsin L orthologs suggest their long co-evolution in the antigen presentation pathway, and genomic analyses suggest 450 million years of conserved Ii exon/intron structure. Other than an extended linker preceding the thyroglobulin-like domain in cartilaginous fish, the Ii gene and protein are predicted to have largely similar physiology from shark to man. Duplicated Ii genes found only in teleosts appear to have become sub-functionalized, as one form is predicted to play the same role as that mediated by Ii mRNA alternative splicing in all other vertebrate classes. No Ii homologs or potential ancestors of any of the functional Ii domains were found in the jawless fish or lower chordates. Copyright © 2011 Elsevier Ltd. All rights reserved.

  20. assessment of slope stability around gilgel gibe-ii hydroelectric

    African Journals Online (AJOL)

    preferred customer

    1 Gilgel-Gibe II Hydroelectric Project, Fofa Town, Ethiopia ... Key words/phrases: Factor of safety, plane failure, slope design, slope .... condition of potential unstable slopes along the road between Fofa town and Gilgel-Gibe Hydro- power II.

  1. Efficiency of Chitosan for the Removal of Pb (II, Fe (II and Cu (II Ions from Aqueous Solutions

    Directory of Open Access Journals (Sweden)

    Soheil Sobhanardakani

    2014-09-01

    Full Text Available Background: Heavy metals have been recognized as harmful environmental pollutant known to produce highly toxic effects on different organs and systems of both humans and animals. The aim of this paper is to evaluate the adsorption potential of chitosan for the removal of Pb(II, Fe(II and Cu(II ions from aqueous solutions. Methods: This study was conducted in laboratory scale. In this paper chitosan has been used as an adsorbent for the removal of Pb(II, Fe(II and Cu(II from aqueous solution. In batch tests, the effects of parameters like pH solution (1.0-8.0, initial metal concentrations (100-1000 mgL-1, contact time (5.0-150 min and adsorbent dose (1.0-7.0 g on the adsorption process were studied. Results: The results showed that the adsorption of Pb(II, Fe(II and Cu(II ions on chitosan strongly depends on pH. The experimental isothermal data were analyzed using the Langmuir and Freundlich equations and it was found that the removal process followed the Langmuir isotherm and maximum adsorption capacity for the adsorption of Pb(II, Fe(II and Cu(II ions by the chitosan were 55.5mg g−1, 71.4 mg g−1 and 59 mg g−1, respectively, under equilibrium conditions at 25±1 ºC. The adsorption process was found to be well described by the pseudo-second-order rate model. Conclusion: The obtained results showed that chitosan is a readily, available, economic adsorbent and was found suitable for removing Pb(II, Fe(II and Cu(II ions from aqueous solution.

  2. Synthesis and characterisation of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II ...

    Indian Academy of Sciences (India)

    Unknown

    Synthesis and characterisation of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) Schiff base complexes derived from o-phenylenediamine and acetoacetanilide. N RAMAN*, Y PITCHAIKANI RAJA and A KULANDAISAMY. Department of Chemistry, VHNSN College, Virudhunagar 626 001, India e-mail: ra_man@123india.com.

  3. Ionization from short-range potential under action of electromagnetic field of complex configuration

    CERN Document Server

    Rodionov, V N; Kravtsova, G A

    2002-01-01

    The transcendental equation for the complex energy is obtained on the basis of the exactly solvable 3D model of the short-acting potential and the Green time function in the intensive electromagnetic field, constituting the combination of the constant magnetic field and the circular-polarization wave field. The electron quasistationary states parameters in the delta-potential with an account of the action of the intensive external field of complex configuration are calculated. The problem on the possibility of stabilizing the bound states decay of the spinor and scalar particles through the intensive magnetic field is clarified. It is established that the obtained results regime the reexamination of the accepted notion on the stabilizing role of the strong magnetic field by the atoms ionization

  4. Floating potential in electronegative plasmas for non-zero ion temperatures

    Science.gov (United States)

    Regodón, Guillermo Fernando; Fernández Palop, José Ignacio; Tejero-del-Caz, Antonio; Díaz-Cabrera, Juan Manuel; Carmona-Cabezas, Rafael; Ballesteros, Jerónimo

    2018-02-01

    The floating potential of a Langmuir probe immersed in an electronegative plasma is studied theoretically under the assumption of radial positive ion fluid movement for non-zero positive ion temperature: both cylindrical and spherical geometries are studied. The model is solvable exactly. The special characteristics of the electronegative pre-sheath are found and the influence of the stratified electronegative pre-sheath is shown to be very small in practical applications. It is suggested that the use of the floating potential in the measurement of negative ions population density is convenient, in view of the numerical results obtained. The differences between the two radial geometries, which become very important for small probe radii of the order of magnitude of the Debye length, are studied.

  5. Optimization of simultaneous electrochemical determination of Cd(II), Pb(II), Cu(II) and Hg(II) at carbon nanotube-modified graphite electrodes.

    Science.gov (United States)

    Pikna, L'ubomír; Heželová, Mária; Kováčová, Zuzana

    2015-01-01

    The health of the environment is worsening every day. Monitoring of potentially toxic elements and remediation of environmental pollution are necessary. Therefore, the research and development of simple, inexpensive, portable and effective sensors is important. Electrochemistry is a useful component of the field of environment monitoring. The present study focuses on evaluating and comparing three types of electrodes (PIGE, PIGE/MWCNT/HNO3 and PIGE/MWCNT/EDTA/HNO3) employed for the simultaneous electrochemical determination of four potentially toxic elements: Cd(II), Pb(II), Cu(II) and Hg(II). Cyclic voltammograms were measured in an acetate buffer. The LOD, LOQ, the standard and relative precisions of the method and a prediction intervals were calculated (according to the technical procedure DIN 32 645) for the three electrodes and for each measured element. The LOD for PIGE/CNT/HNO3 (the electrode with narrowest calculated prediction intervals) was 2.98 × 10(-7) mol L(-1) for Cd(II), 4.83 × 10(-7) mol L(-1) for Pb(II), 3.81 × 10(-7) mol L(-1) for Cu(II), 6.79 × 10(-7) mol L(-1) for Hg(II). One of the benefits of this study was the determination of the amount of Hg(II) in the mixture of other elements.

  6. Oscillator potential for the four-dimensional Hall effect

    International Nuclear Information System (INIS)

    Mardoyan, Levon; Nersessian, Armen

    2005-01-01

    We suggest an exactly solvable model of an oscillator on a four-dimensional sphere interacting with an SU(2) Yang monopole. We show that the properties of the model essentially depend on the monopole charge

  7. Parameters for characterisation of the ecochemical soil status and the potential hazards of acidification and nitrogen saturation in level II forest sites; Kennwerte zur Charakterisierung des oekochemischen Bodenzustandes und des Gefaehrdungspotentials durch Bodenversauerung und Stickstoffsaettigung an Level II-Waldoekosystem-Dauerbeobachtungsflaechen

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The ad hoc working group on soil acidification and nitrogen saturation of the Federal Government/Laender Working Group level II primarily aimed at drafting a manual for the interpretation of soil data (soil solid phase, soil solution) acquired on Level II plots. The manual contains parameters and proposals for evaluating the acid/base-status of forest soils, the nutrient supply and nitrogen status as well as for assessing the risks caused by aluminium, acid and heavy metal stress. Further parameters and proposals for evaluation concern the risks for spring and ground water quality through acidification and elevated nitrate concentrations. All parameters are described in detail, their informative value is discussed and examples are given for their use. A distinction is made between indicators to show the current ecochemical situation and to describe future risks, e.g. through progressive soil acidification, nutrient depletion and increasing nitrogen saturation. The manual thus fits in right with the overall objectives of the Level II Programme to reveal cause-effect relations in the forest damage situation and to give advice on timely counteraction via forecasts of the future development. (orig.) [German] Das vorrangige Ziel des Arbeitskreises 'Bodenversauerung und Stickstoffsaettigung' der Bundes-Laender-Arbeitsgruppe Level II war die Erarbeitung eines Auswerteleitfadens fuer die Bodendaten (Bodenfestphase, Sickerwasser) der Level II-Flaechen. Der Leitfaden enthaelt Kennwerte und Bewertungsvorschlaege zum Saeure-Base-Zustand des Waldbodens, zur Naehrstoffbereitstellung, zum Stickstoffstatus, zur Abschaetzung von Risiken durch Aluminium-, Saeure- und Schwermetallstress und zur Gefaehrdung des Quell- und Grundwassers durch Versauerung und steigende Nitratgehalte. Alle Kennwerte werden eingehend beschrieben, ihre Aussagekraft diskutiert und ihre Anwendung an Beispielen dargestellt. Unterschieden wird zwischen Indikatoren zur Darstellung der aktuellen

  8. Band structure of an electron in a kind of periodic potentials with singularities

    Science.gov (United States)

    Hai, Kuo; Yu, Ning; Jia, Jiangping

    2018-06-01

    Noninteracting electrons in some crystals may experience periodic potentials with singularities and the governing Schrödinger equation cannot be defined at the singular points. The band structure of a single electron in such a one-dimensional crystal has been calculated by using an equivalent integral form of the Schrödinger equation. Both the perturbed and exact solutions are constructed respectively for the cases of a general singular weak-periodic system and its an exactly solvable version, Kronig-Penney model. Any one of them leads to a special band structure of the energy-dependent parameter, which results in an effective correction to the previous energy-band structure and gives a new explanation for forming the band structure. The used method and obtained results could be a valuable aid in the study of energy bands in solid-state physics, and the new explanation may trigger investigation to different physical mechanism of electron band structures.

  9. (II) COMPLEX COMPOUND

    African Journals Online (AJOL)

    user

    electrochemical sensors, as well as in various chromatographic ... were carried out using Jenway pH meter Model 3320 and a conductivity ... Figure 1: the proposed molecular structure of the copper (II) Schiff base complex. M = Cu (II) or Mn (II).

  10. and copper(II)

    Indian Academy of Sciences (India)

    Unknown

    (II) and copper(II)–zinc(II) complexes. SUBODH KUMAR1, R N PATEL1*, P V KHADIKAR1 and. K B PANDEYA2. 1 Department of Chemistry, APS University, Rewa 486 003, India. 2 CSJM University, Kanpur 208 016, India e-mail: (R N Patel) ...

  11. Absorption dynamics and delay time in complex potentials

    Science.gov (United States)

    Villavicencio, Jorge; Romo, Roberto; Hernández-Maldonado, Alberto

    2018-05-01

    The dynamics of absorption is analyzed by using an exactly solvable model that deals with an analytical solution to Schrödinger’s equation for cutoff initial plane waves incident on a complex absorbing potential. A dynamical absorption coefficient which allows us to explore the dynamical loss of particles from the transient to the stationary regime is derived. We find that the absorption process is characterized by the emission of a series of damped periodic pulses in time domain, associated with damped Rabi-type oscillations with a characteristic frequency, ω = (E + ε)/ℏ, where E is the energy of the incident waves and ‑ε is energy of the quasidiscrete state of the system induced by the absorptive part of the Hamiltonian; the width γ of this resonance governs the amplitude of the pulses. The resemblance of the time-dependent absorption coefficient with a real decay process is discussed, in particular the transition from exponential to nonexponential regimes, a well-known feature of quantum decay. We have also analyzed the effect of the absorptive part of the potential on the dynamical delay time, which behaves differently from the one observed in attractive real delta potentials, exhibiting two regimes: time advance and time delay.

  12. Ionic electrodeposition of II-VI and III-V compounds. III. Computer simulation of quasi-rest potentials for M/sub 1/X/sub 1/ compounds analogous to CdTe

    International Nuclear Information System (INIS)

    Engelken, R.D.

    1987-01-01

    The quasi-rest potential (QRP) has been proposed as a key quantity in characterizing compound semiconductor (e.g. CdTe) electrodeposition. This article expands the modeling/simulation representative of Cd/sub x/Te in chemical equilibrium to calculate two ''QRP's'': E/sub M/1/sub /, the mixed potential occurring immediately after current interruption and before any relaxation in double layer ion concentration and significant ion exchange/surface stoichiometry change occur, and E/sub M/2/sub /, another mixed potential occurring after the double layer ion concentrations have relaxed to their bulk values but still before any significant surface composition change occurs. Significant predictions include existence of a dramatic negative transition in QRP, with negative-going deposition potential, centered on the potential of perfect stoichiometry (PPS), inequality, in general, between the PPS and E/sub M/1/sub / unless the deposit remains in equilibrium with the electrolyte (no ion exchange at open circuit), negligible sensitivity of QRP-E curves to the activity coefficient parameter implying the importance of the PPS in characterizing compound deposition, and disappearance of the transition structure for sufficiently positive Gibbs free energies

  13. Pius II. a utrakvismus

    OpenAIRE

    Šimek, Milan

    2009-01-01

    Milan Šimek Pius II. a utrakvismus Pius II. and utraquism Based on sources work - out, the thesis aims the description and analysis of the attitude alternation of Enea Sylvio Piccolomini - Pius II to the utraquism. The conclusions stress the postulate that Pius II. did not change that attitude, but just did not succed in quelling the utraquist movement. In the sense of political background that finally led to fatal dissention among both leaders, king Jiří of Poděbrady and pope Pius II.

  14. A general method for the derivation of the functional forms of the effective energy terms in coarse-grained energy functions of polymers. II. Backbone-local potentials of coarse-grained O 1 →4 -bonded polyglucose chains

    Science.gov (United States)

    Lubecka, Emilia A.; Liwo, Adam

    2017-09-01

    Based on the theory of the construction of coarse-grained force fields for polymer chains described in our recent work [A. K. Sieradzan et al., J. Chem. Phys. 146, 124106 (2017)], in this work effective coarse-grained potentials, to be used in the SUGRES-1P model of polysaccharides that is being developed in our laboratory, have been determined for the O ⋯O ⋯O virtual-bond angles (θ ) and for the dihedral angles for rotation about the O ⋯O virtual bonds (γ ) of 1 → 4 -linked glucosyl polysaccharides, for all possible combinations of [α ,β ]-[d,l]-glucose. The potentials of mean force corresponding to the virtual-bond angles and the virtual-bond dihedral angles were calculated from the free-energy surfaces of [α ,β ]-[d,l]-glucose pairs, determined by umbrella-sampling molecular-dynamics simulations with the AMBER12 force field, or combinations of the surfaces of two pairs sharing the overlapping residue, respectively, by integrating the respective Boltzmann factor over the dihedral angles λ for the rotation of the sugar units about the O ⋯O virtual bonds. Analytical expressions were subsequently fitted to the potentials of mean force. The virtual-bond-torsional potentials depend on both virtual-bond-dihedral angles and virtual-bond angles. The virtual-bond-angle potentials contain a single minimum at about θ =14 0° for all pairs except β -d-[α ,β ] -l-glucose, where the global minimum is shifted to θ =150° and a secondary minimum appears at θ =90°. The torsional potentials favor small negative γ angles for the α -d-glucose and extended negative angles γ for the β -d-glucose chains, as observed in the experimental structures of starch and cellulose, respectively. It was also demonstrated that the approximate expression derived based on Kubo's cluster-cumulant theory, whose coefficients depend on the identity of the disugar units comprising a trisugar unit that defines a torsional potential, fits simultaneously all

  15. Complexes of cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and dioxouranium(II) with thiophene-2-aldehydethiosemicarbazone

    International Nuclear Information System (INIS)

    Singh, Balwan; Misra, Harihar

    1986-01-01

    Metal complexes of thiosemicarbazides have been known for their pharmacological applications. Significant antitubercular, fungicidal and antiviral activities have been reported for thiosemicarbazides and their derivatives. The present study describes the systhesis and characterisation of complexes of Co II , Cu II , Zn II ,Cd II and UO II with thiosemicarbazone obtained by condensing thiophene-2-aldehyde with thiosemicarbazide. 17 refs., 2 tables. (author)

  16. Selective Hg(II) adsorption from aqueous solutions of Hg(II) and Pb(II) by hydrolyzed acrylamide-grafted PET films.

    Science.gov (United States)

    Rahman, Nazia; Sato, Nobuhiro; Sugiyama, Masaaki; Hidaka, Yoshiki; Okabe, Hirotaka; Hara, Kazuhiro

    2014-01-01

    Selective Hg(II) adsorption from aqueous solutions of Hg(II) and Pb(II) using hydrolyzed acrylamide (AAm)-grafted polyethylene terephthalate (PET) films was examined to explore the potential reuse of waste PET materials. Selective recovery of Hg(II) from a mixture of soft acids with similar structure, such as Hg(II) and Pb(II), is important to allow the reuse of recovered Hg(II). An adsorbent for selective Hg(II) adsorption was prepared by γ-ray-induced grafting of AAm onto PET films followed by partial hydrolysis through KOH treatment. The adsorption capacity of the AAm-grafted PET films for Hg(II) ions increased from 15 to 70 mg/g after partial hydrolysis because of the reduction of hydrogen bonding between -CONH2 groups and the corresponding improved access of metal ions to the amide groups. The prepared adsorbent was characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. The absorbent film showed high selectivity for the adsorption of Hg(II) over Pb(II) throughout the entire initial metal concentration range (100-500 mg/L) and pH range (2.2-5.6) studied. The high selectivity is attributed to the ability of Hg(II) ions to form covalent bonds with the amide groups. The calculated selectivity coefficient for the adsorbent binding Hg(II) over Pb(II) was 19.2 at pH 4.5 with an initial metal concentration of 100 mg/L. Selective Hg(II) adsorption equilibrium data followed the Langmuir model and kinetic data were well fitted by a pseudo-second-order equation. The adsorbed Hg(II) and Pb(II) ions were effectively desorbed from the adsorbent film by acid treatment, and the regenerated film showed no marked loss of adsorption capacity upon reuse for selective Hg(II) adsorption.

  17. Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations.

    Science.gov (United States)

    Williams, Hywel D; Sassene, Philip; Kleberg, Karen; Calderone, Marilyn; Igonin, Annabel; Jule, Eduardo; Vertommen, Jan; Blundell, Ross; Benameur, Hassan; Müllertz, Anette; Pouton, Colin W; Porter, Christopher J H

    2013-12-01

    Recent studies have shown that digestion of lipid-based formulations (LBFs) can stimulate both supersaturation and precipitation. The current study has evaluated the drug, formulation and dose-dependence of the supersaturation - precipitation balance for a range of LBFs. Type I, II, IIIA/B LBFs containing medium-chain (MC) or long-chain (LC) lipids, and lipid-free Type IV LBF incorporating different doses of fenofibrate or tolfenamic acid were digested in vitro in a simulated intestinal medium. The degree of supersaturation was assessed through comparison of drug concentrations in aqueous digestion phases (APDIGEST) during LBF digestion and the equilibrium drug solubility in the same phases. Increasing fenofibrate or tolfenamic acid drug loads (i.e., dose) had negligible effects on LC LBF performance during digestion, but promoted drug crystallization (confirmed by XRPD) from MC and Type IV LBF. Drug crystallization was only evident in instances when the calculated maximum supersaturation ratio (SR(M)) was >3. This threshold SR(M) value was remarkably consistent across all LBF and was also consistent with previous studies with danazol. The maximum supersaturation ratio (SR(M)) provides an indication of the supersaturation 'pressure' exerted by formulation digestion and is strongly predictive of the likelihood of drug precipitation in vitro. This may also prove effective in discriminating the in vivo performance of LBFs.

  18. On the pseudo-norm in some PT-symmetric potentials

    International Nuclear Information System (INIS)

    Levai, G.

    2005-01-01

    Complete text of publication follows. PT-symmetric quantum mechanical systems possess non-hermitian Hamiltonian, still they have some characteristics similar to hermitian problems. The most notable of these is their discrete energy spectrum, which can be partly or completely real. These systems are invariant under the simultaneous action of the P space and T time inversion operations. Perhaps the simplest PT-symmetric Hamiltonian contains a one-dimensional Schroedinger operator with a complex potential satisfying the V*(-x) = V (x) relation. Another typical feature PT-symmetric systems have in common with hermitian problems is that their basis states form an orthogonal set provided that the inner product is redefined as (ψ φ)PT ≡ (ψ Pφ). However, the norm defined by this inner product, the pseudo-norm turned out to possess indefinite sign, and this raised the question of the probabilistic interpretation of PT-symmetric systems. This problem was later put into a more general context when it was found that PT symmetry is a special case of pseudo-hermiticity, and this explains most of the peculiar features of PT-symmetric systems. There have been several attempts to link PT-symmetric, and in general, pseudo- hermitian systems with equivalent hermitian ones, and the sign of the pseudo-norm was found to play an important role in this respect. It is thus essential to evaluate the pseudo- norm for various potentials, especially considering the fact that there are some inconsistencies in the available results. Numerical studies indicated that the sign of the pseudo-norm typically alternates according to the n principal quantum number as (-1) n , and this was later proven for a class of potentials that are written in a polynomial form of ix. However, some potentials of other type did not fit into this line: this was the case for the Scarf II potential, the most well-known exactly solvable PT-symmetric potential. In contrast with the other examples, this potential is

  19. Phase II clinical development of new drugs

    CERN Document Server

    Ting, Naitee; Ho, Shuyen; Cappelleri, Joseph C

    2017-01-01

    This book focuses on how to appropriately plan and develop a Phase II program, and how to design Phase II clinical trials and analyze their data. It provides a comprehensive overview of the entire drug development process and highlights key questions that need to be addressed for the successful execution of Phase II, so as to increase its success in Phase III and for drug approval. Lastly it warns project team members of the common potential pitfalls and offers tips on how to avoid them.

  20. Thiol-functionalized polysilsesquioxane as efficient adsorbent for adsorption of Hg(II) and Mn(II) from aqueous solution

    International Nuclear Information System (INIS)

    Niu, Yuzhong; Qu, Rongjun; Liu, Xiguang; Mu, Lei; Bu, Baihui; Sun, Yuting; Chen, Hou; Meng, Yangfeng; Meng, Lina; Cheng, Lin

    2014-01-01

    Highlights: • PMPSQ was promising adsorbent for the removal of Hg(II) and Mn(II). • The adsorption kinetics followed the pseudo-second-order model. • The adsorption isotherms can be described by the monolayer Langmuir model. • The adsorption was controlled by film diffusion and chemical ion-exchange mechanism. - Abstract: Thiol-functionalized polysilsesquioxane was synthesized and used for the adsorption of Hg(II) and Mn(II) from aqueous solution. Results showed that the optimal pH was about 6 and 5 for Hg(II) and Mn(II), respectively. Adsorption kinetics showed that the adsorption equilibriums were established within 100 min and followed pseudo-second-order model. Adsorption isotherms revealed that the adsorption capacities increased with the increasing of temperature. The adsorption was found to be well described by the monolayer Langmuir isotherm model and took place by chemical ion-exchange mechanism. The thermodynamic properties indicated the adsorption processes were spontaneous and endothermic nature. Selectively adsorption showed that PMPSQ can selectively adsorb Hg(II) from binary ion systems in the presence of the coexistent ions Mn(II), Cu(II), Pb(II), Co(II), and Ni(II). Based on the results, it is concluded that PMPSQ had comparable high adsorption efficiency and could be potentially used for the removal of Hg(II) and Mn(II) from aqueous solution

  1. Options Study - Phase II

    Energy Technology Data Exchange (ETDEWEB)

    R. Wigeland; T. Taiwo; M. Todosow; W. Halsey; J. Gehin

    2010-09-01

    The Options Study has been conducted for the purpose of evaluating the potential of alternative integrated nuclear fuel cycle options to favorably address the issues associated with a continuing or expanding use of nuclear power in the United States. The study produced information that can be used to inform decisions identifying potential directions for research and development on such fuel cycle options. An integrated nuclear fuel cycle option is defined in this study as including all aspects of the entire nuclear fuel cycle, from obtaining natural resources for fuel to the ultimate disposal of used nuclear fuel (UNF) or radioactive wastes. Issues such as nuclear waste management, especially the increasing inventory of used nuclear fuel, the current uncertainty about used fuel disposal, and the risk of nuclear weapons proliferation have contributed to the reluctance to expand the use of nuclear power, even though it is recognized that nuclear power is a safe and reliable method of producing electricity. In this Options Study, current, evolutionary, and revolutionary nuclear energy options were all considered, including the use of uranium and thorium, and both once-through and recycle approaches. Available information has been collected and reviewed in order to evaluate the ability of an option to clearly address the challenges associated with the current implementation and potential expansion of commercial nuclear power in the United States. This Options Study is a comprehensive consideration and review of fuel cycle and technology options, including those for disposal, and is not constrained by any limitations that may be imposed by economics, technical maturity, past policy, or speculated future conditions. This Phase II report is intended to be used in conjunction with the Phase I report, and much information in that report is not repeated here, although some information has been updated to reflect recent developments. The focus in this Options Study was to

  2. Quininium tetrachloridozinc(II

    Directory of Open Access Journals (Sweden)

    Li-Zhuang Chen

    2009-10-01

    Full Text Available The asymmetric unit of the title compound {systematic name: 2-[hydroxy(6-methoxyquinolin-1-ium-4-ylmethyl]-8-vinylquinuclidin-1-ium tetrachloridozinc(II}, (C20H26N2O2[ZnCl4], consists of a double protonated quininium cation and a tetrachloridozinc(II anion. The ZnII ion is in a slightly distorted tetrahedral coordination environment. The crystal structure is stabilized by intermolecular N—H...Cl and O—H...Cl hydrogen bonds.

  3. Finite Groups with Given Quantitative Non-Nilpotent Subgroups II

    DEFF Research Database (Denmark)

    Shi, Jiangtao; Zhang, Cui

    2014-01-01

    As an extension of Shi and Zhang's 2011 article [4], we prove that any finite group having at most 23 non-normal non-nilpotent proper subgroups is solvable except for G ≅ A 5 or SL(2, 5), and any finite group having at most three conjugacy classes of non-normal non-nilpotent proper subgroups is s...

  4. Modification of the sensitivity and repair of potentially lethal damage by diethyldithiocarbamate during and following exposure of plateau-phase cultures of mammalian cells to radiation and cis-diamminedichloroplatinum(II)

    International Nuclear Information System (INIS)

    Evans, R.G.; Engel, C.; Wheatley, C.; Nielsen, J.

    1982-01-01

    Diethyldithiocarbamate (DDC), a chelating agent known to reduce levels of superoxide dismutase and glutathione peroxidase, appears to protect irradiated monolayers of mammalian cells when present for 1 hr before and during irradiation. To examine a possible cause of this modification, the repair of potentially lethal X-ray damage was examined with and without the presence of DDC in the medium overlying the cells postirradiation. Although little repair was seen in full medium alone when DDC was added to the full medium, the amount of repair was comparable to that seen under optimum repair conditions, that is, in Hanks' balanced salt solution. The t 1/2 of the repair process in Hanks' balanced salt solution or in full medium with DDC added was comparable and of the order of 1 to 1.5 hr. The cis-platinum sensitivity of the monolayers is significantly modified by the addition of DDC, and the nature of the modification is dependent upon the time at which the DDC is added to the cells following initiation of cis-platinum exposure. To investigate a possible reason for this protection by DDC, we examined the repair of potentially lethal cis-platinum damage in the cell monolayers. Minimal repair was noted in the presence of either Hanks' balanced salt solution or full medium, but when DDC was added to the full medium, the repair was tripled, and the t 1/2 of the repair process was approximately 2 hr. The ability of DDC to protect cells from exposure to both X-rays and cis-platinum, together with its augmentation of repair of potentially lethal damage following exposure to each, has broad clinical application and is being actively explored in tumor-bearing mice

  5. Burkina Faso - BRIGHT II

    Data.gov (United States)

    Millennium Challenge Corporation — Millennium Challenge Corporation hired Mathematica Policy Research to conduct an independent evaluation of the BRIGHT II program. The three main research questions...

  6. Solvable quantum two-body problem: entanglement

    International Nuclear Information System (INIS)

    Glasser, M L; Nieto, L M

    2005-01-01

    A simple one-dimensional model is introduced describing a two particle 'atom' approaching a point at which the interaction between the particles is lost. The wavefunction is obtained analytically and analysed to display the entangled nature of the subsequent state. (letter to the editor)

  7. Solvable model of spiral wave chimeras.

    Science.gov (United States)

    Martens, Erik A; Laing, Carlo R; Strogatz, Steven H

    2010-01-29

    Spiral waves are ubiquitous in two-dimensional systems of chemical or biological oscillators coupled locally by diffusion. At the center of such spirals is a phase singularity, a topological defect where the oscillator amplitude drops to zero. But if the coupling is nonlocal, a new kind of spiral can occur, with a circular core consisting of desynchronized oscillators running at full amplitude. Here, we provide the first analytical description of such a spiral wave chimera and use perturbation theory to calculate its rotation speed and the size of its incoherent core.

  8. Exactly solvable models of material breakdown

    International Nuclear Information System (INIS)

    Duxbury, P.M.; Leath, P.L.

    1994-01-01

    We present the solutions to two simple models for the brittle failure of materials containing random flaws. These solutions provide support for simple scaling theories we had previously developed for more complex models, and refute recent claims that models with random dilution scale in a manner similar to a disorderless material. In particular, we find that for these models, the asymptotic size effect in the average strength is logarithmic, and the failure distribution is of an exponential of an exponential form (often with an algebraic prefactor). The method of solution is also interesting. The failure probability of the quasi-one-dimensional models we solve can be written in terms of a transition matrix introduced by Harlow. For large sample sizes, the largest eigenvalue of this transition matrix approaches one, and our solution rests on a perturbative expansion of the largest eigenvalue about one. The small and intermediate lattice behavior of the model is analyzed by using sparse matrix methods to find the largest eigenvalue of the transition matrix, and the trace of powers of the transition matrix

  9. Understanding of QCD through solvable models

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharya, G.

    1980-07-01

    Various aspects of strong interaction physics are discussed. It is shown that several nontrivial features arise from non-perturbative 'solutions' of QCD-like models in (1+1) dimensions. An attempt is made to bring these features in (3+1) dimensional semiclassical treatments of QCD.

  10. Solvable model of quantum microcanonical states

    International Nuclear Information System (INIS)

    Bender, Carl M; Brody, Dorje C; Hook, Daniel W

    2005-01-01

    This letter examines the consequences of a recently proposed modification of the postulate of equal a priori probability in quantum statistical mechanics. This modification, called the quantum microcanonical postulate (QMP), asserts that for a system in microcanonical equilibrium all pure quantum states having the same energy expectation value are realized with equal probability. A simple model of a quantum system that obeys the QMP and that has a nondegenerate spectrum with equally spaced energy eigenvalues is studied. This model admits a closed-form expression for the density of states in terms of the energy eigenvalues. It is shown that in the limit as the number of energy levels approaches infinity, the expression for the density of states converges to a δ function centred at the intermediate value (E max + E min )/2 of the energy. Determining this limit requires an elaborate asymptotic study of an infinite sum whose terms alternate in sign. (letter to the editor)

  11. Characterization and solvability of quasipolynomial symplectic mappings

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez-Bermejo, Benito [ESCET (Edificio Departamental II), Universidad Rey Juan Carlos, Calle Tulipan S/N, 28933-Mostoles-Madrid (Spain); Brenig, Leon [Service de Physique Theorique et Mathematique, Universite Libre de Bruxelles, Campus Plaine, CP 231, Boulevard du Triomphe, B-1050 Brussels (Belgium)

    2004-02-13

    Quasipolynomial (or QP) mappings constitute a wide generalization of the well-known Lotka-Volterra mappings, of importance in different fields such as population dynamics, physics, chemistry or economy. In addition, QP mappings are a natural discrete-time analogue of the continuous QP systems, which have been extensively used in different pure and applied domains. After presenting the basic definitions and properties of QP mappings in a previous paper, the purpose of this work is to focus on their characterization by considering the existence of symplectic QP mappings. In what follows such QP symplectic maps are completely characterized. Moreover, use of the QP formalism can be made in order to demonstrate that all QP symplectic mappings have an analytical solution that is explicitly and generally constructed. Examples are given.

  12. Characterization and solvability of quasipolynomial symplectic mappings

    International Nuclear Information System (INIS)

    Hernandez-Bermejo, Benito; Brenig, Leon

    2004-01-01

    Quasipolynomial (or QP) mappings constitute a wide generalization of the well-known Lotka-Volterra mappings, of importance in different fields such as population dynamics, physics, chemistry or economy. In addition, QP mappings are a natural discrete-time analogue of the continuous QP systems, which have been extensively used in different pure and applied domains. After presenting the basic definitions and properties of QP mappings in a previous paper, the purpose of this work is to focus on their characterization by considering the existence of symplectic QP mappings. In what follows such QP symplectic maps are completely characterized. Moreover, use of the QP formalism can be made in order to demonstrate that all QP symplectic mappings have an analytical solution that is explicitly and generally constructed. Examples are given

  13. Characterization and solvability of quasipolynomial symplectic mappings

    Science.gov (United States)

    Hernández-Bermejo, Benito; Brenig, Léon

    2004-02-01

    Quasipolynomial (or QP) mappings constitute a wide generalization of the well-known Lotka-Volterra mappings, of importance in different fields such as population dynamics, physics, chemistry or economy. In addition, QP mappings are a natural discrete-time analogue of the continuous QP systems, which have been extensively used in different pure and applied domains. After presenting the basic definitions and properties of QP mappings in a previous paper [1], the purpose of this work is to focus on their characterization by considering the existence of symplectic QP mappings. In what follows such QP symplectic maps are completely characterized. Moreover, use of the QP formalism can be made in order to demonstrate that all QP symplectic mappings have an analytical solution that is explicitly and generally constructed. Examples are given.

  14. About the solvability of matrix polynomial equations

    OpenAIRE

    Netzer, Tim; Thom, Andreas

    2016-01-01

    We study self-adjoint matrix polynomial equations in a single variable and prove existence of self-adjoint solutions under some assumptions on the leading form. Our main result is that any self-adjoint matrix polynomial equation of odd degree with non-degenerate leading form can be solved in self-adjoint matrices. We also study equations of even degree and equations in many variables.

  15. Solvable Model of Spiral Wave Chimeras

    DEFF Research Database (Denmark)

    Martens, Erik Andreas; Laing, Carlo R.; Strogatz, Steven H.

    2010-01-01

    Spiral waves are ubiquitous in two-dimensional systems of chemical or biological oscillators coupled locally by diffusion. At the center of such spirals is a phase singularity, a topological defect where the oscillator amplitude drops to zero. But if the coupling is nonlocal, a new kind of spiral...... can occur, with a circular core consisting of desynchronized oscillators running at full amplitude. Here, we provide the first analytical description of such a spiral wave chimera and use perturbation theory to calculate its rotation speed and the size of its incoherent core....

  16. Solvable models and hidden symmetries in QCD

    International Nuclear Information System (INIS)

    Yepez-Martinez, Tochtli; Hess, P. O.; Szczepaniak, A.; Civitarese, O.; Lerma H., S.

    2010-01-01

    We show that QCD Hamiltonians at low energy exhibit an SU(2) structure, when only few orbital levels are considered. In case many orbital levels are taken into account we also find a semi-analytic solution for the energy levels of the dominant part of the QCD Hamiltonian. The findings are important to propose the structure of phenomenological models.

  17. Isovectorial pairing in solvable and algebraic models

    International Nuclear Information System (INIS)

    Lerma, Sergio; Vargas, Carlos E; Hirsch, Jorge G

    2011-01-01

    Schematic interactions are useful to gain some insight in the behavior of very complicated systems such as the atomic nuclei. Prototypical examples are, in this context, the pairing interaction and the quadrupole interaction of the Elliot model. In this contribution the interplay between isovectorial pairing, spin-orbit, and quadrupole terms in a harmonic oscillator shell (the so-called pairing-plus-quadrupole model) is studied by algebraic methods. The ability of this model to provide a realistic description of N = Z even-even nuclei in the fp-shell is illustrated with 44 Ti. Our calculations which derive from schematic and simple terms confirm earlier conclusions obtained by using realistic interactions: the SU(3) symmetry of the quadrupole term is broken mainly by the spin-orbit term, but the energies depends strongly on pairing.

  18. Exactly solvable position dependent mass schroedinger equation

    International Nuclear Information System (INIS)

    Koc, R.; Tuetuencueler, H.; Koercuek, E.

    2002-01-01

    Exact solution of the Schrodinger equation with a variable mass is presented. We have derived general expressions for the eigenstates and eigenvalues of the position dependent mass systems. We provide supersymmetric and Lie algebraic methods to discuss the position dependent mass systems

  19. Utilization of biomass in the U.S. for the production of ethanol fuel as a gasoline replacement. I - Terrestrial resource potential. II - Energy requirements, with emphasis on lignocellulosic conversion

    Science.gov (United States)

    Ferchak, J. D.; Pye, E. K.

    The paper assesses the biomass resource represented by starch derived from feed corn, surplus and distressed grain, and high-yield sugar crops planted on set-aside land in the U.S. It is determined that the quantity of ethanol produced may be sufficient to replace between 5 to 27% of present gasoline requirements. Utilization of novel cellulose conversion technology may in addition provide fermentable sugars from municipal, agricultural and forest wastes, and ultimately from highly productive silvicultural operations. The potential additional yield of ethanol from lignocellulosic biomass appears to be well in excess of liquid fuel requirements of an enhanced-efficiency transport sector at present mileage demands. No conflict with food production would be entailed. A net-energy assessment is made for lignocellulosic biomass feedstocks' conversion to ethanol and an almost 10:1 energy yield/energy cost ratio determined. It is also found that novel cellulose pretreatment and enzymatic conversion methods still under development may significantly improve even that figure, and that both chemical-feedstocks and energy-yielding byproducts such as carbon dioxide, biogas and lignin make ethanol production potentially energy self-sufficient. A final high-efficiency production approach incorporates site-optimized, nonpolluting energy sources such as solar and geothermal.

  20. Determination of Lead(II), Cadmium(II) and Copper(II) in Waste-Water and Soil Extracts on Mercury Film Screen-Printed Carbon Electrodes Sensor

    International Nuclear Information System (INIS)

    Mohd Fairulnizal Md Noh; Tothill, I.E.

    2011-01-01

    A sensor incorporating a three electrodes configuration have been fabricated using low cost screen-printing technology. These electrodes couples with Square Wave Stripping Voltammetry (SWSV) has provided a convenient screening tool for on-site detection of trace levels of Pb(II), Cd(II) and Cu(II). Modification of the graphite carbon surface based on in situ deposition of mercury film has been carried out. By appropriate choice of supporting medium and optimized parameters setting such as amount of mercury used the deposition potential, deposition time, frequency and scan rate, well resolved and reproducible response for Pb(II), Cd(II) and Cu(II) were obtained. The performance characteristics of the developed mercury film screen printed carbon electrode (MFSPCE) for 120 s deposition time showed that the linear range for Cd(II), Pb(II) and Cu(II) were 10 to 200 μg L -1 . The detection limit recorded for Cd(II), Pb(II) and Cu(II) were 2, 1 and 5 μg L -1 with relative standard deviation (RSD) of 6.5 %, 6.9 % and 7.5 %, respectively. Successful applications of the sensing device to waste-water and extracted soil samples were demonstrated. (author)

  1. Biosorption of cadmium (II) and lead (II) from aqueous solutions using mushrooms: A comparative study

    Energy Technology Data Exchange (ETDEWEB)

    Vimala, R., E-mail: vimararagu@yahoo.co.in [School of Biotechnology, Chemical and Biomedical Engineering, VIT University, Vellore 632014, Tamil Nadu (India); Das, Nilanjana [School of Biotechnology, Chemical and Biomedical Engineering, VIT University, Vellore 632014, Tamil Nadu (India)

    2009-08-30

    Sorption capacity of oyster mushroom (Pleurotus platypus), button mushroom (Agaricus bisporus) and milky mushroom (Calocybe indica) were evaluated on biosorption of heavy metals, viz. cadmium (II) and lead (II) from aqueous solutions. The optimum sorption conditions were studied for each metal separately. The desired pH of the aqueous solution was found to be 6.0 for the removal of cadmium (II) and 5.0 for removal of lead (II) for all the mushrooms. The percent removal of both the metals was found to increase with the increase in biosorbent dosage and contact time. The fitness of the biosorption data for Langmuir and Freundlich adsorption models was investigated. It was found that biosorption of cadmium (II) and lead (II) ions onto the biomass of the three mushrooms were better suitable to Langmuir than Freundlich adsorption model. P. platypus showed the highest metal uptake potential for cadmium (q{sub max} 34.96 mg/g) whereas A. bisporus exhibited maximum potential for lead (q{sub max} 33.78 mg/g). Milky mushroom showed the lowest metal uptake capacity for both the metals. The present data confirms that mushrooms may be used as efficient biosorbent for the removal of cadmium (II) and lead (II) ions from aqueous solution.

  2. Sequestration of chelated copper by structural Fe(II): Reductive decomplexation and transformation of Cu{sup II}-EDTA

    Energy Technology Data Exchange (ETDEWEB)

    He, Hongping [State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science & Engineering, Tongji University, Shanghai 200092 (China); Wu, Deli, E-mail: wudeli@tongji.edu.cn [State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science & Engineering, Tongji University, Shanghai 200092 (China); Zhao, Linghui [State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science & Engineering, Tongji University, Shanghai 200092 (China); Luo, Cong [School of Civil and Environmental Engineering, Georgia Institute of Technology, GA 30332 (United States); Dai, Chaomeng; Zhang, Yalei [State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science & Engineering, Tongji University, Shanghai 200092 (China)

    2016-05-15

    Highlights: • Structural Fe(II) was found to reveal high sequestration potential in various chelated copper. • Chelated copper was reduced to Cu(0) and Cu{sub 2}O by =Fe(II), whcih was oxidized to Fe{sub 2}O{sub 3}·H{sub 2}O. • Both electron transfer and surface =Fe(II) were found to be crucial during chelated copper reduction. • The indispensible role of reductive decomplexation was identified in chelated copper sequestration. - Abstract: Chelated coppers, such as Cu{sup II}-EDTA, are characteristically refractory and difficult to break down because of their high stability and solubility. Cu{sup II}–EDTA sequestration by structural Fe(II) (=Fe(II)) was investigated intensively in this study. Up to 101.21 mgCu(II)/gFe(II) was obtained by =Fe(II) in chelated copper sequestration under near neutral pH condition (pH 7.70). The mechanism of Cu{sup II}-EDTA sequestration by =Fe(II) was concluded as follows: 3Cu{sup II}–EDTA + 7=Fe(II) + 9H{sub 2}O → Cu(0) ↓ + Cu{sub 2}O ↓ (the major product) + 2Fe{sub 2}O{sub 3}·H{sub 2}O ↓ + 3Fe{sup II}–EDTA +14H{sup +} Novel results strongly indicate that Cu{sup II} reductive transformation induced by surface =Fe(II) was mainly responsible for chelated copper sequestration. Cu(0) generation was initially facilitated, and subsequent reduction of Cu(II) into Cu(I) was closely combined with the gradual increase of ORP (Oxidation-Reduction Potential). Cu-containing products were inherently stable, but Cu{sub 2}O would be reoxidized to Cu(II) with extra-aeration, resulting in the release of copper, which was beneficial to Cu reclamation. Concentration diminution of Cu{sup II}–EDTA within the electric double layer and competitive adsorption were responsible for the negative effects of Ca{sup 2+}, Mg{sup 2+}. By generating vivianite, PO{sub 4}{sup 3−} was found to decrease surface =Fe(II) content. This study is among the first ones to identify the indispensible role of reductive decomplexation in chelated copper

  3. cobalt(II), nickel(II)

    Indian Academy of Sciences (India)

    Unknown

    procedures. The supporting electrolyte, NaClO4 used in the voltammetric experiment was purchased from. Sigma. IR spectra were recorded in KBr medium on .... (13⋅6). L = Schiff base ligand form of one broad band envelope. The electronic spectra of Co(II) complex showed two spin-allowed transitions at 17856 and ...

  4. The processing and characterization of animal-derived bone to yield materials with biomedical applications. Part II: milled bone powders, reprecipitated hydroxyapatite and the potential uses of these materials.

    Science.gov (United States)

    Johnson, G S; Mucalo, M R; Lorier, M A; Gieland, U; Mucha, H

    2000-11-01

    Further studies on the processing and use of animal-bone-derived calcium phosphate materials in biomedical applications are presented. Bone powders sourced either from the direct crushing and milling of bovine, ovine and cervine bone or after being subjected to defatting and acid digestion/NaOH reprecipitation and sodium hypochlorite hydrogen peroxide treatment of animal bones were characterized using Fourier transform infra-red (FTIR) spectroscopy, 13C solid state magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy, atomic absorption (AA) and inductively coupled plasma (ICP) spectrometric techniques. Bone powders were trialled for their potential use as a substrate for phosphine coupling and enzyme immobilization as well as a feedstock powder for plasma spraying on titanium metal substrates. Results indicated that enzyme immobilization by phosphine coupling could be successfully achieved on milled cervine bone with the immobilized enzyme retaining some activity. It was found that the presence of impurities normally carried down with the processing of the bone materials (viz., fat and collagen) played an important role in influencing the adsorbency and reactivity of the powders. Plasma spraying studies using reprecipitated bovine-derived powders produced highly adherent coatings on titanium metal, the composition of which was mostly hydroxyapatite (Ca10(PO4)6(OH)2) with low levels of alpha-tricalcium phosphate (alpha-Ca3(PO4)2) and tetracalcium phosphate (Ca4P2O9) also detected. In general, animal derived calcium phosphate materials constitute a potentially cheaper source of calcium phosphate materials for biomedical applications and make use of a largely under-utilized resource from abattoir wastes. Copyright 2000 Kluwer Academic Publishers

  5. Nuclear physics II

    International Nuclear Information System (INIS)

    Elze, T.

    1988-01-01

    This script consisting of two parts contains the matter of the courses Nuclear Pyhsics I and II, as they were presented in the winter term 1987/88 and summer term 1988 for students of physics at Frankfurt University. In the present part II the matter of the summer term is summarized. (orig.) [de

  6. World War II Homefront.

    Science.gov (United States)

    Garcia, Rachel

    2002-01-01

    Presents an annotated bibliography that provides Web sites focusing on the U.S. homefront during World War II. Covers various topics such as the homefront, Japanese Americans, women during World War II, posters, and African Americans. Includes lesson plan sources and a list of additional resources. (CMK)

  7. Nonlinear theory of scattering by localized potentials in metals

    Energy Technology Data Exchange (ETDEWEB)

    Howard, I A [Department of Physics, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp (Belgium); March, N H [Department of Physics, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp (Belgium); Oxford University, Oxford (United Kingdom); Echenique, P M [Donostia International Physics Center (DIPC), 20018 San Sebastian, Basque Country (Spain); Departamento de Fisica de Materiales and Centro Mixto CSIC-UPV/EHU, Facultad de Quimicas, UPV/EHU, Apartado 1072, 20080, San Sebastian (Spain)

    2003-11-14

    In early work, March and Murray gave a perturbation theory of the Dirac density matrix {gamma}(r, r') generated by a localized potential V(r) embedded in an initially uniform Fermi gas to all orders in V(r). For potentials sufficiently slowly varying in space, they summed the resulting series for r' = r to regain the Thomas-Fermi density {rho}(r) {proportional_to} [{mu} - V(r)]{sup 3/2}, with {mu} the chemical potential of the Fermi gas. For an admittedly simplistic repulsive central potential V(r) = vertical bar A vertical bar exp(-cr), it is first shown here that what amounts to the sum of the March-Murray series for the s-wave (only) contribution to the density, namely {rho}{sub s}(r, {mu}), can be obtained in closed form. Furthermore, for specific numerical values of A and c in this exponential potential, the long-range behaviour of {rho}{sub s}(r, {mu}) is related to the zero-potential form of March and Murray, which merely suffers a {mu}-dependent phase shift. This result is interpreted in relation to the recent high density screening theorem of Zaremba, Nagy and Echenique. A brief discussion of excess electrical resistivity caused by nonlinear scattering in a Fermi gas is added; this now involves an off-diagonal local density of states. Finally, for periodic lattices, contact is made with the quantum-mechanical defect centre models of Koster and Slater (1954 Phys. Rev. 96 1208) and of Beeby (1967 Proc. R. Soc. A 302 113), and also with the semiclassical approximation of Friedel (1954 Adv. Phys. 3 446). In appendices, solvable low-dimensional models are briefly summarized.

  8. Reconstructing bidimensional scalar field theory models

    International Nuclear Information System (INIS)

    Flores, Gabriel H.; Svaiter, N.F.

    2001-07-01

    In this paper we review how to reconstruct scalar field theories in two dimensional spacetime starting from solvable Scrodinger equations. Theree different Schrodinger potentials are analyzed. We obtained two new models starting from the Morse and Scarf II hyperbolic potencials, the U (θ) θ 2 In 2 (θ 2 ) model and U (θ) = θ 2 cos 2 (In(θ 2 )) model respectively. (author)

  9. Biologically active new Fe(II, Co(II, Ni(II, Cu(II, Zn(II and Cd(II complexes of N-(2-thienylmethylenemethanamine

    Directory of Open Access Journals (Sweden)

    C. SPÎNU

    2008-04-01

    Full Text Available Iron(II, cobalt(II, nickel (II, copper (II, zinc(II and cadmium(II complexes of the type ML2Cl2, where M is a metal and L is the Schiff base N-(2-thienylmethylenemethanamine (TNAM formed by the condensation of 2-thiophenecarboxaldehyde and methylamine, were prepared and characterized by elemental analysis as well as magnetic and spectroscopic measurements. The elemental analyses suggest the stoichiometry to be 1:2 (metal:ligand. Magnetic susceptibility data coupled with electronic, ESR and Mössbauer spectra suggest a distorted octahedral structure for the Fe(II, Co(II and Ni(II complexes, a square-planar geometry for the Cu(II compound and a tetrahedral geometry for the Zn(II and Cd(II complexes. The infrared and NMR spectra of the complexes agree with co-ordination to the central metal atom through nitrogen and sulphur atoms. Conductance measurements suggest the non-electrolytic nature of the complexes, except for the Cu(II, Zn(II and Cd(II complexes, which are 1:2 electrolytes. The Schiff base and its metal chelates were screened for their biological activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the metal chelates were found to possess better antibacterial activity than that of the uncomplexed Schiff base.

  10. Evaluation of an approach for the characterization of reactive and available pools of 20 potentially toxic elements in soils: part II--solid-solution partition relationships and ion activity in soil solutions.

    Science.gov (United States)

    Rodrigues, S M; Henriques, B; Ferreira da Silva, E; Pereira, M E; Duarte, A C; Groenenberg, J E; Römkens, P F A M

    2010-12-01

    To assess environmental risks related to contaminants in soil it is essential to predict the available pool of inorganic contaminants at regional scales, accounting for differences between soils from variable geologic and climatic origins. An approach composed of a well-accepted soil extraction procedure (0.01 M CaCl(2)) and empirical Freundlich-type models in combination with mechanistically based models which to date have been used only in temperate regions was applied to 136 soils from a South European area and evaluated for its possible general use in risk assessment. Empirical models based on reactive element pools and soil properties (pH, organic carbon, clay, total Al, Fe and Mn) provided good estimations of available concentrations for a broad range of contaminants including As, Ba, Cd, Co, Cu, Hg, Mo, Ni, Pb, Sb, Se and Zn (r(2): 0.46-0.89). The variation of the pools of total Al in soils expressed the sorptive capacity of aluminosilicates and Al oxides at the surfaces and edges of clay minerals better than the actual variability of clay contents. The approach has led to recommendations for further research with particular emphasis on the impact of clay on the solubility of As and Sb, on the mechanisms controlling Cr and U availability and on differences in binding properties of soil organic matter from different climatic regions. This study showed that such approach may be included with a good degree of certainty for first step risk assessment procedures to identify potential risk areas for leaching and uptake of inorganic contaminants in different environmental settings. Copyright © 2010 Elsevier Ltd. All rights reserved.

  11. 9th International Symposium on the Biosafety of Genetically Modified Organisms. Session II: Identifying and defining hazards and potential consequences I: Concepts for problem formulation and non-target risk assessment.

    Science.gov (United States)

    Bigler, Franz

    2006-01-01

    The scientific organizers of the symposium put much emphasis on the identification and definition of hazard and the potential consequences thereof and three full sessions with a total of 13 presentations encompassing a wide range of related themes were planned for this topic. Unfortunately, one talk had to be cancelled because of illness of the speaker (BM Khadi, India). Some presentations covered conceptual approaches for environmental risk assessment (ERA) of GM plants (problem formulation in the risk assessment framework, familiarity approach, tiered and methodological frameworks, non-target risk assessment) and the use of models in assessing invasiveness and weediness of GM plants. Other presentations highlighted the lessons learned for future ERA from case studies and commercialized GM crops, and from monitoring of unintended releases to the environment. When the moderators of the three sessions came together after the presentations to align their summaries, there was an obvious need to restructure the 12 presentations in a way that allowed for a consistent summarizing discussion. The following new organization of the 12 talks was chosen: (1) Concepts for problem formulation and non-target risk assessment, (2) Modeling as a tool for predicting invasiveness of GM plants, (3) Case-studies of ERA of large-scale release, (4) Lessons learned for ERA from a commercialized GM plant, (5) Monitoring of unintended release of Bt maize in Mexico. The new thematic structure facilitates a more in-depth discussion of the presentations related to a specific topic, and the conclusions to be drawn are thus more consistent. Each moderator agreed to take responsibility for summarizing one or more themes and to prepare the respective report.

  12. Evolved H II regions

    International Nuclear Information System (INIS)

    Churchwell, E.

    1975-01-01

    A probable evolutionary sequence of H II regions based on six distinct types of observed objects is suggested. Two examples which may deviate from this idealized sequence, are discussed. Even though a size-mean density relation of H II regions can be used as a rough indication of whether a nebula is very young or evolved, it is argued that such a relation is not likely to be useful for the quantitative assignment of ages to H II regions. Evolved H II regions appear to fit into one of four structural types: rings, core-halos, smooth structures, and irregular or filamentary structures. Examples of each type are given with their derived physical parameters. The energy balance in these nebulae is considered. The mass of ionized gas in evolved H II regions is in general too large to trace the nebula back to single compact H II regions. Finally, the morphological type of the Galaxy is considered from its H II region content. 2 tables, 2 figs., 29 refs

  13. Position-Dependent Mass Schrödinger Equation for the Morse Potential

    International Nuclear Information System (INIS)

    Ovando, G; Peña, J J; Morales, J; López-Bonilla, J

    2017-01-01

    The position dependent mass Schrödinger equation (PDMSE) has a wide range of quantum applications such as the study of semiconductors, quantum wells, quantum dots and impurities in crystals, among many others. On the other hand, the Morse potential is one of the most important potential models used to study the electronic properties of diatomic molecules. In this work, the solution of the effective mass one-dimensional Schrödinger equation for the Morse potential is presented. This is done by means of the canonical transformation method in algebraic form. The PDMSE is solved for any model of the proposed kinetic energy operators as for example the BenDaniel-Duke, Gora-Williams, Zhu-Kroemer or Li-Kuhn. Also, in order to solve the PDMSE with Morse potential, we consider a superpotential leading to a special form of the exactly solvable Schrödinger equation of constant mass for a class of multiparameter exponential-type potential along with a proper mass distribution. The proposed approach is general and can be applied in the search of new potentials suitable on science of materials by looking into the viable choices of the mass function. (paper)

  14. Preliminary PBFA II design

    International Nuclear Information System (INIS)

    Johnson, D.L.; VanDevender, J.P.; Martin, T.H.

    1980-01-01

    The upgrade of Sandia National Laboratories particle beam fusion accelerator, PBFA I, to PBFA II presents several interesting and challenging pulsed power design problems. PBFA II requires increasing the PBFA I output parameters from 2 MV, 30 TW, 1 MJ to 4 MV, 100 TW, 3.5 MJ with the constraint of using much of the same PBFA I hardware. The increased PBFA II output will be obtained by doubling the number of modules (from 36 to 72), increasing the primary energy storage (from 4 MJ to 15 MJ), lowering the pulse forming line (PFL) output impedance, and adding a voltage doubling network

  15. Mn(II), Zn(II) and VO(II) Schiff

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 113; Issue 3. Synthesis and characterisation of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) Schiff base complexes derived from o-phenylenediamine and acetoacetanilide. N Raman Y Pitchaikani Raja A Kulandaisamy. Inorganic Volume 113 Issue 3 June 2001 pp 183-189 ...

  16. Identification and Characterization of Novel Immunomodulatory Bursal-derived Pentapeptide-II (BPP-II)*

    Science.gov (United States)

    Feng, Xiu-Li; Liu, Qing-Tao; Cao, Rui-Bing; Zhou, Bin; Ma, Zhi-Yong; Deng, Wen-Lei; Wei, Jian-Chao; Qiu, Ya-Feng; Wang, Fang-Quan; Gu, Jin-Yan; Wang, Feng-Juan; Zheng, Qi-Sheng; Ishag, Hassan; Chen, Pu-Yan

    2012-01-01

    The bursa of Fabricius, the acknowledged central humoral immune organ, plays a vital role in B lymphocyte differentiation. However, there are few reports of the molecular basis of the mechanism on immune induction and potential antitumor activity of bursal-derived peptides. In this paper, a novel bursal-derived pentapeptide-II (BPP-II, MTLTG) was isolated and exerted immunomodulatory functions on antibody responses in vitro. Gene microarray analyses demonstrated that BPP-II regulated expression of 2478 genes in a mouse-derived hybridoma cell line. Immune-related gene ontology functional procedures were employed for further functional analysis. Furthermore, the majority of BPP-II-regulated pathways were associated with immune responses and tumor processes. Moreover, BPP-II exhibited immunomodulatory effects on antigen-specific immune responses in vivo, including enhancement of avian influenza virus (H9N2 subtype)-specific antibody and cytokine production and modification of T cell immunophenotypes and lymphocyte proliferation. Finally, BPP-II triggered p53 expression and stabilization and selectively inhibited tumor cell proliferation. These data identified the multifunctional factor, BPP-II, as a novel biomaterial representing an important linking between the humoral central immune system and immune induction, including antitumor. Information generated in this study elucidates further the mechanisms involved in humoral immune system and represents the potential basis of effective immunotherapeutic strategies for treating human tumors and immune improvement. PMID:22184121

  17. Identification and characterization of novel immunomodulatory bursal-derived pentapeptide-II (BPP-II).

    Science.gov (United States)

    Feng, Xiu-Li; Liu, Qing-Tao; Cao, Rui-Bing; Zhou, Bin; Ma, Zhi-Yong; Deng, Wen-Lei; Wei, Jian-Chao; Qiu, Ya-Feng; Wang, Fang-Quan; Gu, Jin-Yan; Wang, Feng-Juan; Zheng, Qi-Sheng; Ishag, Hassan; Chen, Pu-Yan

    2012-02-03

    The bursa of Fabricius, the acknowledged central humoral immune organ, plays a vital role in B lymphocyte differentiation. However, there are few reports of the molecular basis of the mechanism on immune induction and potential antitumor activity of bursal-derived peptides. In this paper, a novel bursal-derived pentapeptide-II (BPP-II, MTLTG) was isolated and exerted immunomodulatory functions on antibody responses in vitro. Gene microarray analyses demonstrated that BPP-II regulated expression of 2478 genes in a mouse-derived hybridoma cell line. Immune-related gene ontology functional procedures were employed for further functional analysis. Furthermore, the majority of BPP-II-regulated pathways were associated with immune responses and tumor processes. Moreover, BPP-II exhibited immunomodulatory effects on antigen-specific immune responses in vivo, including enhancement of avian influenza virus (H9N2 subtype)-specific antibody and cytokine production and modification of T cell immunophenotypes and lymphocyte proliferation. Finally, BPP-II triggered p53 expression and stabilization and selectively inhibited tumor cell proliferation. These data identified the multifunctional factor, BPP-II, as a novel biomaterial representing an important linking between the humoral central immune system and immune induction, including antitumor. Information generated in this study elucidates further the mechanisms involved in humoral immune system and represents the potential basis of effective immunotherapeutic strategies for treating human tumors and immune improvement.

  18. Antibacterial, antimalarial and leishmanicidal activities of Cu (II) and nickel (II) complexes of diclofenac sodium

    International Nuclear Information System (INIS)

    Rehman, F.U.; Khan, M.F.; Khan, G.M.; Khan, H.; Khan, I.U.

    2010-01-01

    Metal complexes are famous for a wide array of chemotherapeutic effects. The current study was designed to synthesize and evaluate unexplored chemotherapeutic effects of Cu (II) and Nickel (II) complexes of the non-steroidal anti-inflammatory drug diclofenac. Nickel complex exhibited significant leishmanicidal activity against Lieshmania major, while the copper complex was found to possess low activity against the same pathogen. Both of the complexes revealed low antibacterial activities and were interestingly failed to produce any considerable antimalarial activity against Plasmodium falciparum 3D7. Selective leishmanicidal activities of Nickel (II) complex of diclofenac needs further improvement to be developed as potential new metal-based leishmanicidal agent.(author)

  19. Antibacterial, antimalarial and leishmanicidal activities of Cu (II) and nickel (II) complexes of diclofenac sodium

    Energy Technology Data Exchange (ETDEWEB)

    Rehman, F U; Khan, M F; Khan, G M; Khan, H [Gomal University, D.I. Khan (Pakistan). Dept. of Faculty of Pharmacy; Khan, I U [University of Peshawar (Pakistan). Dept. of Faculty of Pharmacy

    2010-08-15

    Metal complexes are famous for a wide array of chemotherapeutic effects. The current study was designed to synthesize and evaluate unexplored chemotherapeutic effects of Cu (II) and Nickel (II) complexes of the non-steroidal anti-inflammatory drug diclofenac. Nickel complex exhibited significant leishmanicidal activity against Lieshmania major, while the copper complex was found to possess low activity against the same pathogen. Both of the complexes revealed low antibacterial activities and were interestingly failed to produce any considerable antimalarial activity against Plasmodium falciparum 3D7. Selective leishmanicidal activities of Nickel (II) complex of diclofenac needs further improvement to be developed as potential new metal-based leishmanicidal agent.(author)

  20. The Belle II Experiment

    CERN Document Server

    Kahn, J

    2017-01-01

    Set to begin data taking at the end of 2018, the Belle II experiment is the next-generation B-factory experiment hosted at KEK in Tsukuba, Japan. The experiment represents the cumulative effort from the collaboration of experimental and detector physics, computing, and software development. Taking everything learned from the previous Belle experiment, which ran from 1998 to 2010, Belle II aims to probe deeper than ever before into the field of heavy quark physics. By achieving an integrated luminosity of 50 ab−1 and accumulating 50 times more data than the previous experiment across its lifetime, along with a rewritten analysis framework, the Belle II experiment will push the high precision frontier of high energy physics. This paper will give an overview of the key components and development activities that make the Belle II experiment possible.

  1. Factor II assay

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003674.htm Factor II assay To use the sharing features on ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  2. Factor II deficiency

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000549.htm Factor II deficiency To use the sharing features on ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  3. Ni(II

    African Journals Online (AJOL)

    Preferred Customer

    analytical chemistry, catalysis, electrochemistry, ring-opening metathesis ... Ethanol was dried over anhydrous copper(II) sulfate and distilled over metallic sodium. ... All bacteria were inoculated into Nutrient Broth (Difco) and incubated for 24 h ...

  4. NNDSS - Table II. Vibriosis

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table II. Vibriosis - 2017. In this Table, provisional cases of selected notifiable diseases (≥1,000 cases reported during the preceding year), and selected...

  5. Disruption Rose Tinted II

    OpenAIRE

    Livingstone, Andrew

    2009-01-01

    'Disruption - Rose Tinted II' continues to engage narratives of historical English china as previously explored in the work 'Rose Tinted'. This work engages the sleepy rural idyll which is overlaid with visual contemporary social commentary.

  6. NNDSS - Table II. Vibriosis

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table II. Vibriosis - 2018. In this Table, provisional cases of selected notifiable diseases (≥1,000 cases reported during the preceding year), and selected...

  7. Gamble II Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Gamble II produces a high-voltage (2 MV), high-current (1 MA), short (100 ns) pulse of energy of either positive or negative polarity. This terawatt power...

  8. Leo II PC

    Data.gov (United States)

    Kansas Data Access and Support Center — LEO II is a second-generation software system developed for use on the PC, which is designed to convert location references accurately between legal descriptions and...

  9. Tokapole II device

    International Nuclear Information System (INIS)

    Sprott, J.G.

    1978-05-01

    A discussion is given of the design and operation of the Tokapole II device. The following topics are considered: physics considerations, vacuum vessel, poloidal field, ring and support design, toroidal field, vacuum system, initial results, and future plans

  10. copper(II)

    Indian Academy of Sciences (India)

    Unknown

    bis(2,2,6,6-tetramethyl-3,5-heptadionato)copper(II) ... Abstract. Equilibrium concentrations of various condensed and gaseous phases have been thermodyna- ... phere, over a wide range of substrate temperatures and total reactor pressures.

  11. Digital optical computer II

    Science.gov (United States)

    Guilfoyle, Peter S.; Stone, Richard V.

    1991-12-01

    OptiComp is currently completing a 32-bit, fully programmable digital optical computer (DOC II) that is designed to operate in a UNIX environment running RISC microcode. OptiComp's DOC II architecture is focused toward parallel microcode implementation where data is input in a dual rail format. By exploiting the physical principals inherent to optics (speed and low power consumption), an architectural balance of optical interconnects and software code efficiency can be achieved including high fan-in and fan-out. OptiComp's DOC II program is jointly sponsored by the Office of Naval Research (ONR), the Strategic Defense Initiative Office (SDIO), NASA space station group and Rome Laboratory (USAF). This paper not only describes the motivational basis behind DOC II but also provides an optical overview and architectural summary of the device that allows the emulation of any digital instruction set.

  12. SPEAR II performance

    International Nuclear Information System (INIS)

    Paterson, J.M.

    1975-01-01

    The single beam and colliding beam performance of the SLAC electron-positron storage ring SPEAR II is described. The sevenfold increase in harmonic number in SPEAR II in comparison to SPEAR I has made significant changes in single beam behavior. Strong synchrobetatron resonances and a new transverse instability are observed, and our first studies of these phenomena are described. Measurements on current dependent bunch lengthening are presented. (auth)

  13. Computing at Belle II

    International Nuclear Information System (INIS)

    Kuhr, Thomas

    2012-01-01

    Belle II, a next-generation B-factory experiment, will search for new physics effects in a data sample about 50 times larger than the one collected by its predecessor, the Belle experiment. To match the advances in accelerator and detector technology, the computing system and the software have to be upgraded as well. The Belle II computing model is presented and an overview of the distributed computing system and the offline software framework is given.

  14. Nsls-II Boster

    Science.gov (United States)

    Gurov, S. M.; Akimov, A. V.; Akimov, V. E.; Anashin, V. V.; Anchugov, O. V.; Baranov, G. N.; Batrakov, A. M.; Belikov, O. V.; Bekhtenev, E. A.; Blum, E.; Bulatov, A. V.; Burenkov, D. B.; Cheblakov, P. B.; Chernyakin, A. D.; Cheskidov, V. G.; Churkin, I. N.; Davidsavier, M.; Derbenev, A. A.; Erokhin, A. I.; Fliller, R. P.; Fulkerson, M.; Gorchakov, K. M.; Ganetis, G.; Gao, F.; Gurov, D. S.; Hseuh, H.; Hu, Y.; Johanson, M.; Kadyrov, R. A.; Karnaev, S. E.; Karpov, G. V.; Kiselev, V. A.; Kobets, V. V.; Konstantinov, V. M.; Kolmogorov, V. V.; Korepanov, A. A.; Kramer, S.; Krasnov, A. A.; Kremnev, A. A.; Kuper, E. A.; Kuzminykh, V. S.; Levichev, E. B.; Li, Y.; Long, J. De; Makeev, A. V.; Mamkin, V. R.; Medvedko, A. S.; Meshkov, O. I.; Nefedov, N. B.; Neyfeld, V. V.; Okunev, I. N.; Ozaki, S.; Padrazo, D.; Petrov, V. V.; Petrichenkov, M. V.; Philipchenko, A. V.; Polyansky, A. V.; Pureskin, D. N.; Rakhimov, A. R.; Rose, J.; Ruvinskiy, S. I.; Rybitskaya, T. V.; Sazonov, N. V.; Schegolev, L. M.; Semenov, A. M.; Semenov, E. P.; Senkov, D. V.; Serdakov, L. E.; Serednyakov, S. S.; Shaftan, T. V.; Sharma, S.; Shichkov, D. S.; Shiyankov, S. V.; Shvedov, D. A.; Simonov, E. A.; Singh, O.; Sinyatkin, S. V.; Smaluk, V. V.; Sukhanov, A. V.; Tian, Y.; Tsukanova, L. A.; Vakhrushev, R. V.; Vobly, P. D.; Utkin, A. V.; Wang, G.; Wahl, W.; Willeke, F.; Yaminov, K. R.; Yong, H.; Zhuravlev, A.; Zuhoski, P.

    The National Synchrotron Light Source II is a third generation light source, which was constructed at Brookhaven National Laboratory. This project includes a highly-optimized 3 GeV electron storage ring, linac preinjector, and full-energy synchrotron injector. Budker Institute of Nuclear Physics built and delivered the booster for NSLS-II. The commissioning of the booster was successfully completed. This paper reviews fulfilled work by participants.

  15. (4- hydroxybenzaldehyde) - p - phenylenediamine zinc(ii)

    African Journals Online (AJOL)

    PROF EKWUEME

    The structure of compounds I and II have been studied with the help of Infrared and UV- visible spectroscopy. ... metal organic framework with a potential application in .... 1260C for compound I is an indication of weak binding forces in the ...

  16. Microbunching phenomena in LCLS-II

    Energy Technology Data Exchange (ETDEWEB)

    Venturini, M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Qiang, J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Papadopoulos, C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Ding, Y. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Emma, P. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Huang, Z. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Marcus, G. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Marinelli, A. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Nosochkov, Y. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Raubenheimer, T. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Wang, L. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Woodley, M. [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-07-14

    The microbunching instability has long been recognized as a potential limiting factor to the performance of X-ray FELs. It is of particular relevance in LCLS-II due, in part, to a layout that includes a long bypass beamline between the Linac and the undulators. Here we focus on two aspects of the instability that highlight the importance of 3D effects.

  17. Synthesis and studies on Cu(II), Co(II), Ni(II) complexes of Knoevenagel β-diketone ligands

    Science.gov (United States)

    Sumathi, S.; Tharmaraj, P.; Sheela, C. D.; Anitha, C.

    2012-11-01

    Transition metal complexes of various acetylacetone based ligands of the type ML [where M = Cu(II), Ni(II), Co(II); L = 3-(aryl)-pentane-2,4-dione] have been synthesized. The structural features have been derived from their elemental analysis, magnetic susceptibility, molar conductance, IR, UV-Vis, 1H NMR, Mass and ESR spectral studies. Conductivity measurements reveal that all the complexes are non-electrolytic in nature. Spectroscopic and other analytical data of the complexes suggest octahedral geometry for other metal(II) complexes. The redox behavior of the copper(II) complexes have been studied by cyclic voltammetry. The free ligands and their metal complexes have been screened for their in vitro biological activities against the bacteria Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus as well as the fungus Candida albicans by well diffusion method. The zone of inhibition value indicates that the most of the metal(II) complexes are found to possess increased activities compared to those of the free ligands. All synthesized compounds may serve as potential photoactive materials as indicated from their characteristic fluorescence properties. The second harmonic generation (SHG) efficiency of the ligands (L1-L3) was found to be considerable effect than that of urea and KDP (potassium dihydrogen phosphate).

  18. Being a potentially responsible party

    International Nuclear Information System (INIS)

    Ronan, J.T.

    1989-01-01

    This paper reports on CERCLA II- ability for the unlucky potentially responsible parties (PRPs) which is a Draconian form of strict, joint and several liability with limited statutory defenses that in most cases are impossible to establish. CERCLA vigorously employs these legal concepts, stretching a PRP's financial exposure to the limits necessary to meet the enormous financial costs of remediation

  19. The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger.

    Science.gov (United States)

    Gangloff, Y G; Pointud, J C; Thuault, S; Carré, L; Romier, C; Muratoglu, S; Brand, M; Tora, L; Couderc, J L; Davidson, I

    2001-08-01

    The RNA polymerase II transcription factor TFIID comprises the TATA binding protein (TBP) and a set of TBP-associated factors (TAF(II)s). TFIID has been extensively characterized for yeast, Drosophila, and humans, demonstrating a high degree of conservation of both the amino acid sequences of the constituent TAF(II)s and overall molecular organization. In recent years, it has been assumed that all the metazoan TAF(II)s have been identified, yet no metazoan homologues of yeast TAF(II)47 (yTAF(II)47) and yTAF(II)65 are known. Both of these yTAF(II)s contain a histone fold domain (HFD) which selectively heterodimerizes with that of yTAF(II)25. We have cloned a novel mouse protein, TAF(II)140, containing an HFD and a plant homeodomain (PHD) finger, which we demonstrated by immunoprecipitation to be a mammalian TFIID component. TAF(II)140 shows extensive sequence similarity to Drosophila BIP2 (dBIP2) (dTAF(II)155), which we also show to be a component of Drosophila TFIID. These proteins are metazoan homologues of yTAF(II)47 as their HFDs selectively heterodimerize with dTAF(II)24 and human TAF(II)30, metazoan homologues of yTAF(II)25. We further show that yTAF(II)65 shares two domains with the Drosophila Prodos protein, a recently described potential dTAF(II). These conserved domains are critical for yTAF(II)65 function in vivo. Our results therefore identify metazoan homologues of yTAF(II)47 and yTAF(II)65.

  20. Potential Theory

    CERN Document Server

    Lukeš, Jaroslav; Netuka, Ivan; Veselý, Jiří

    1988-01-01

    Within the tradition of meetings devoted to potential theory, a conference on potential theory took place in Prague on 19-24, July 1987. The Conference was organized by the Faculty of Mathematics and Physics, Charles University, with the collaboration of the Institute of Mathematics, Czechoslovak Academy of Sciences, the Department of Mathematics, Czech University of Technology, the Union of Czechoslovak Mathematicians and Physicists, the Czechoslovak Scientific and Technical Society, and supported by IMU. During the Conference, 69 scientific communications from different branches of potential theory were presented; the majority of them are in­ cluded in the present volume. (Papers based on survey lectures delivered at the Conference, its program as well as a collection of problems from potential theory will appear in a special volume of the Lecture Notes Series published by Springer-Verlag). Topics of these communications truly reflect the vast scope of contemporary potential theory. Some contributions deal...

  1. DNA binding and biological activity of mixed ligand complexes of Cu(II, Ni(II and Co(II with quinolones and N donor ligand

    Directory of Open Access Journals (Sweden)

    S.M M Akram

    2015-10-01

    Full Text Available  AbstractMixed ligand complexes of  Cu(II, Ni(II and Co(II have been synthesized by using levofloxacin and bipyridyl and characterized using spectral and analytical techniques. The binding behavior of the Ni(II and Cu(II complexes with herring sperm DNA(Hs-DNA were determined using electronic absorption titration, viscometric measurements and cyclic voltammetry measurements. The binding constant calculated  for Cu(II and Ni(II complexes are 2.0 x 104 and 4.0 x 104 M-1 respectively. Detailed analysis reveals that these metal complexes interact with DNA through intercalative binding mode. The nuclease activity of  Cu(II and Ni(II complexes with ct-DNA was carried out using agarose gel electrophoresis technique. The antioxidant activities for the synthesized complexes have been tested and the antibacterial activity for Ni(II complex was also checked.Key words: Intercalation, hypochromism, red shift and  peak potential.

  2. Equilibrium Sorption Studies of Hg (II) Ions from Aqueous Solution ...

    African Journals Online (AJOL)

    The potential of swamp arum (Lasimorpha senegalensis) seeds as a low-cost adsorbent for the removal of Hg (II) ions from aqueous solution was investigated in this study. The influence of initial metal concentration on the percent adsorption of Hg (II) ions onto powdered swamp arum seeds was studied in a batch system ...

  3. Process optimization and mechanistic studies of lead (II): Aspergillus ...

    African Journals Online (AJOL)

    The lead (II) accumulation potential of various biosorbent had been widely studied in the last few years, but an outstanding Pb(II) accumulating biomass still seems crucial for bringing the process to a successful application stage. This investigation describes the use of non-living biomass of Aspergillus caespitosus for ...

  4. Multipurpose Electric Potential Sensor for Spacecraft Applications, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The original goal of Phase I was to study the feasibility of developing an electric sensor that can be used for as many NASA sensing applications as possible. During...

  5. Potential bags

    International Nuclear Information System (INIS)

    Ferreira, P.L.; Tomio, L.

    1992-01-01

    In this paper, relativistic confining potential models, endowed with bag constants associated to volume energy terms, are investigated. In contrast to the usual bag model, these potential bags are distinguished by having smeared bag surfaces. Based on the dynamical assumptions underlying the fuzzy bag model, these bag constants are derived from the corresponding energy-momentum tensor. Explicit expressions for the single-quark energies and for the nucleon bag constant are obtained by means of an improved analytical version of the saddle-point variational method for the Dirac equation with confining power-law potentials of the scalar plus vector (S + V) or pure scalar (S) type

  6. II-VI semiconductor compounds

    CERN Document Server

    1993-01-01

    For condensed matter physicists and electronic engineers, this volume deals with aspects of II-VI semiconductor compounds. Areas covered include devices and applications of II-VI compounds; Co-based II-IV semi-magnetic semiconductors; and electronic structure of strained II-VI superlattices.

  7. Groundwater Potential

    African Journals Online (AJOL)

    big timmy

    4Department of Geology, Ekiti State University, Ado-Ekiti, Nigeria. Corresponding ... integrated for the classification of the study area into different groundwater potential zones. .... table is mainly controlled by subsurface movement of water into ...

  8. About APPLE II Operation

    International Nuclear Information System (INIS)

    Schmidt, T.; Zimoch, D.

    2007-01-01

    The operation of an APPLE II based undulator beamline with all its polarization states (linear horizontal and vertical, circular and elliptical, and continous variation of the linear vector) requires an effective description allowing an automated calculation of gap and shift parameter as function of energy and operation mode. The extension of the linear polarization range from 0 to 180 deg. requires 4 shiftable magnet arrrays, permitting use of the APU (adjustable phase undulator) concept. Studies for a pure fixed gap APPLE II for the SLS revealed surprising symmetries between circular and linear polarization modes allowing for simplified operation. A semi-analytical model covering all types of APPLE II and its implementation will be presented

  9. VATICANO II CONCILIO DOCTRINAL?

    Directory of Open Access Journals (Sweden)

    Horacio Bojorge

    1970-01-01

    Full Text Available It is a century since the army of Victor Manuel invaded Rome and put an end to Vatican I. In this article we try to understand Vatican II linking it to the previous circumtances and binding it to its doctrinal and pastoral character. Vatican II omitted many subjects that seemed important, e. g. not giving any dogmatic definitions. Contrasting with the Tridentine and Vatican I, that were mostly doctrinal, Vatican II was pastoral. But it was also doctrinal as were the two previous also pastoral. The Constitution "Dei Verbum" brings forth the intentions that led John XXIII to summon the Council in 5-8-1962. The world looked confused and agitated. What could the Church do?

  10. The decline and fall of Type II error rates

    Science.gov (United States)

    Steve Verrill; Mark Durst

    2005-01-01

    For general linear models with normally distributed random errors, the probability of a Type II error decreases exponentially as a function of sample size. This potentially rapid decline reemphasizes the importance of performing power calculations.

  11. Datalogger usando nios ii

    OpenAIRE

    Campoverde Rugel, Luis Enrique; Velásquez Vargas, Washington Adrián; Ponguillo, Ronald

    2013-01-01

    El presente proyecto consiste en la implementación de un Datalogger utilizando el microprocesador NIOS II el cual fue embebido en el FPGA CYCLONE II que se encuentra integrada en la tarjeta de desarrollo ALTERA DE2, el cual obtiene datos de distintos sensores y los almacena en una tarjeta SD Card. Para la realización del proyecto se aplican cuatro etapas. La primera etapa está basada en obtener los datos mediante el uso de sensores y la transmisión usando un PIC, la siguiente etapa se basa...

  12. Results from SAGE II

    International Nuclear Information System (INIS)

    Nico, J.S.

    1994-01-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first nine runs of SAGE II give a capture rate of 66 -13 +18 (stat) -7 +5 (sys) SNU. Combined with the SAGE I result of 73 -16 +18 (stat) -7 5 (sys) SNU, the capture rate is 69 -11 +11 (stat) -7 +5 (sys) SNU. This represents only 52%--56% of the capture rate predicted by different Standard Solar Models

  13. Information on Asse II

    International Nuclear Information System (INIS)

    2014-01-01

    The brochure published by BfS describes the actual situation of Asse II with respect to the debate on an interim storage and the status of the realization of a final repository search law. During the visit of the new environment minister Hendricks in the underground facility repository Asse II the issue interim storage site and the retrieval of the corroded casks with radioactive waste were discussed. The challenges for BFS include the acceleration of the retrieval process and the safety of the procedure.

  14. ECLESIOLOGIA DO VATICANO II

    Directory of Open Access Journals (Sweden)

    Víctor Codina

    2013-01-01

    Full Text Available Não se pode compreender a eclesiologia do Vaticano II sem conhecer a vida, o estilo pastoral e o carisma de João XXIII, que convocou o Concílio e abriu o caminho em direção a uma nova configuração eclesial que acabava com séculos de uma Igreja de Cristandade. O Vaticano II implica uma transição de uma Igreja clerical a uma Igreja Povo de Deus, povo de batizados. A passagem de uma Igreja juridicista e legalista a uma Igreja Mistério de comunhão em Cristo. Mudar de uma Igreja triunfalista e ligada ao poder mundano a uma Igreja vivificada pela força renovadora do Espírito. A Igreja está a caminho rumo ao Reino de Deus juntamente com todos os cristãos e com toda a humanidade. A recepção do Vaticano II supõe uma conversão pastoral: voltar ao Evangelho e abrir-se aos novos sinais dos tempos seguindo o Espírito que inspirou João XXIII. ABSTRACT: You cannot understand the Ecclesiology of Vatican II without knowing the life, the pastoral style and the charisma of John XXIII, who convened the Council and opened the way toward a new ecclesial setting that ended centuries of a church of Christendom. The Vatican II involves a transition from a clerical Church to a “People (baptized people of God” Church. The Vatican II implies the passage from a juridical and legalistic Church to a Church as the Mystery of the communion in Christ. The Vatican II implies the change from a triumphalistic Church and connected to worldly power to a Church vivified by the renewing force of the Spirit. The Church is on its way toward the Kingdom of God together with all Christians and all mankind. The reception of the Vatican II supposes a pastoral conversion: a return to the Gospel and openness to new signs of the times following the Spirit that inspired John XXIII.

  15. Calculus II For Dummies

    CERN Document Server

    Zegarelli, Mark

    2012-01-01

    An easy-to-understand primer on advanced calculus topics Calculus II is a prerequisite for many popular college majors, including pre-med, engineering, and physics. Calculus II For Dummies offers expert instruction, advice, and tips to help second semester calculus students get a handle on the subject and ace their exams. It covers intermediate calculus topics in plain English, featuring in-depth coverage of integration, including substitution, integration techniques and when to use them, approximate integration, and improper integrals. This hands-on guide also covers sequences and series, wit

  16. Electrochemical, spectroscopic, and photophysical properties of structurally diverse polyazine-bridged Ru(II),Pt(II) and Os(II),Ru(II),Pt(II) supramolecular motifs.

    Science.gov (United States)

    Knoll, Jessica D; Arachchige, Shamindri M; Wang, Guangbin; Rangan, Krishnan; Miao, Ran; Higgins, Samantha L H; Okyere, Benjamin; Zhao, Meihua; Croasdale, Paul; Magruder, Katherine; Sinclair, Brian; Wall, Candace; Brewer, Karen J

    2011-09-19

    Five new tetrametallic supramolecules of the motif [{(TL)(2)M(dpp)}(2)Ru(BL)PtCl(2)](6+) and three new trimetallic light absorbers [{(TL)(2)M(dpp)}(2)Ru(BL)](6+) (TL = bpy = 2,2'-bipyridine or phen = 1,10-phenanthroline; M = Ru(II) or Os(II); BL = dpp = 2,3-bis(2-pyridyl)pyrazine, dpq = 2,3-bis(2-pyridyl)quinoxaline, or bpm = 2,2'-bipyrimidine) were synthesized and their redox, spectroscopic, and photophysical properties investigated. The tetrametallic complexes couple a Pt(II)-based reactive metal center to Ru and/or Os light absorbers through two different polyazine BL to provide structural diversity and interesting resultant properties. The redox potential of the M(II/III) couple is modulated by M variation, with the terminal Ru(II/III) occurring at 1.58-1.61 V and terminal Os(II/III) couples at 1.07-1.18 V versus Ag/AgCl. [{(TL)(2)M(dpp)}(2)Ru(BL)](PF(6))(6) display terminal M(dπ)-based highest occupied molecular orbitals (HOMOs) with the dpp(π*)-based lowest unoccupied molecular orbital (LUMO) energy relatively unaffected by the nature of BL. The coupling of Pt to the BL results in orbital inversion with localization of the LUMO on the remote BL in the tetrametallic complexes, providing a lowest energy charge separated (CS) state with an oxidized terminal Ru or Os and spatially separated reduced BL. The complexes [{(TL)(2)M(dpp)}(2)Ru(BL)](6+) and [{(TL)(2)M(dpp)}(2)Ru(BL)PtCl(2)](6+) efficiently absorb light throughout the UV and visible regions with intense metal-to-ligand charge transfer (MLCT) transitions in the visible at about 540 nm (M = Ru) and 560 nm (M = Os) (ε ≈ 33,000-42,000 M(-1) cm(-1)) and direct excitation to the spin-forbidden (3)MLCT excited state in the Os complexes about 720 nm. All the trimetallic and tetrametallic Ru-based supramolecular systems emit from the terminal Ru(dπ)→dpp(π*) (3)MLCT state, λ(max)(em) ≈ 750 nm. The tetrametallic systems display complex excited state dynamics with quenching of the (3)MLCT emission at

  17. Eight joint BER II and BESSY II users meeting. Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-07-01

    The following topics were dealt with: Accelerator operation and projecs, photon science and instrumentation at BESSY II, status of energy materials in-situ Lab at BESSY II, high resolution spectrometer PEAXIS at BESSY II, sample environment at BESSY II, molecular control mechanisms in the Brr2 RNA helicase for efficient and regulated splicing, the Li conversion reaction of 4CoFe{sub 2}O{sub 4} nanoparticles, buried interfaces in lithium ion batteries probed with HAXPES, ARPES studies of the STO(001) 2DEG, all-in/all-out magnetic order in rare earth iridates, oxygen reduction reaction on graphene in Li-air batteries, electronic order in high-T{sub c} superconductors, in-siu observation of novel switching phenomena in highly porous metal-organic frameworks, photoinduced demagnetization and insulator-to-metal transition in ferromagnetic insulating BaFeO{sub 3} thin films, ARPES measurement of the ferroelectric bulk Rashba system GeTe, bisphenol A on Cu(111) and Ag(111), reverse water-gas shift or Sabathier methanation on N(110), structural studies of molecular machines, multi-MHz time-of-flight electronic band-structure imaging of graphene on Ir(111), diffusion pathways in ion conductors, ground-state potential energy surfaces around selected atoms from resonant inelastic X-ray scattering, solar energy in an emerging country, in-situ neutron analysis of electrode materials for electrochemical energy storage, structure and transport properties in thermoelectric skutterudites, investigation of the interphase formation on solid lithium-ion conductors by neutron reflectometry, load partitin and damage characterization of cast AlSi{sub 12}CuMgNi alloy with ceramic reinforcement, methane adsorption in highly porous metal-organics, structure and magnetic interactions in dimer system Ba{sub (3-x)}Sr{sub x}Cr{sub 2}O{sub 8}, distribution of S in C-S nanocomposites, current status of HFM-EXED FACITIY; SPIN NEAMTICITY IN s=1/2 frustrated zigzag chaIN β-TeVO{sub 4}, electronic

  18. Eight joint BER II and BESSY II users meeting. Abstracts

    International Nuclear Information System (INIS)

    2016-01-01

    The following topics were dealt with: Accelerator operation and projecs, photon science and instrumentation at BESSY II, status of energy materials in-situ Lab at BESSY II, high resolution spectrometer PEAXIS at BESSY II, sample environment at BESSY II, molecular control mechanisms in the Brr2 RNA helicase for efficient and regulated splicing, the Li conversion reaction of 4CoFe_2O_4 nanoparticles, buried interfaces in lithium ion batteries probed with HAXPES, ARPES studies of the STO(001) 2DEG, all-in/all-out magnetic order in rare earth iridates, oxygen reduction reaction on graphene in Li-air batteries, electronic order in high-T_c superconductors, in-siu observation of novel switching phenomena in highly porous metal-organic frameworks, photoinduced demagnetization and insulator-to-metal transition in ferromagnetic insulating BaFeO_3 thin films, ARPES measurement of the ferroelectric bulk Rashba system GeTe, bisphenol A on Cu(111) and Ag(111), reverse water-gas shift or Sabathier methanation on N(110), structural studies of molecular machines, multi-MHz time-of-flight electronic band-structure imaging of graphene on Ir(111), diffusion pathways in ion conductors, ground-state potential energy surfaces around selected atoms from resonant inelastic X-ray scattering, solar energy in an emerging country, in-situ neutron analysis of electrode materials for electrochemical energy storage, structure and transport properties in thermoelectric skutterudites, investigation of the interphase formation on solid lithium-ion conductors by neutron reflectometry, load partitin and damage characterization of cast AlSi_1_2CuMgNi alloy with ceramic reinforcement, methane adsorption in highly porous metal-organics, structure and magnetic interactions in dimer system Ba_(_3_-_x_)Sr_xCr_2O_8, distribution of S in C-S nanocomposites, current status of HFM-EXED FACITIY; SPIN NEAMTICITY IN s=1/2 frustrated zigzag chaIN β-TeVO_4, electronic properties of U(Ru_0_._9_2Rh_0_._0_8)_2Si_2 in

  19. Receptor binding radiotracers for the angiotensin II receptor: radioiodinated [Sar1, Ile8]angiotensin II

    International Nuclear Information System (INIS)

    Gibson, R.E.; Beauchamp, H.T.; Fioravanti, C.; Brenner, N.; Burns, H.D.

    1994-01-01

    The potential for imaging the angiotensin II receptor was evaluated using the radioiodinated peptide antagonist [ 125 I][Sar 1 , Ile 8 ]angiotensin II. The radioligand provides a receptor-mediated signal in several tissues in rat (kidneys, adrenal and liver). The receptor-mediated signal of 3% ID/g kidney cortex should be sufficient to permit imaging, at least via SPECT. The radiotracer is sensitive to reductions in receptor concentration and can be used to define in vivo dose-occupancy curves of angiotensin II receptor ligands. Receptor-mediated images of [ 123 I][Sar 1 , Ile 8 ]angiotensin II were obtained in the rat kidney and Rhesus monkey liver. (author)

  20. Periodontics II: Course Proposal.

    Science.gov (United States)

    Dordick, Bruce

    A proposal is presented for Periodontics II, a course offered at the Community College of Philadelphia to give the dental hygiene/assisting student an understanding of the disease states of the periodontium and their treatment. A standardized course proposal cover form is given, followed by a statement of purpose for the course, a list of major…