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Sample records for solvable potentials ii

  1. Proton radioactivity with analytically solvable potential

    Indian Academy of Sciences (India)

    The phenomenon of proton emission is treated as a process of asymmetric fission through a one-dimensional potential barrier developed due to combined effects of the Coulomb potential, centrifugal potential and various renormalization processes. The barrier is simulated to an asymmetric, smooth and analytically solvable ...

  2. Application of quasiexactly solvable potential method to the N-body ...

    Indian Academy of Sciences (India)

    The importance of exactly solvable potentials in quantum mechanics is well known. But even in a one-dimensional case, the number of such potentials are limited [1]. The quasiexactly solvable (QES) potentials are intermediate to exactly solvable and non- solvable ones and the Schrödinger equations of these potentials are ...

  3. Exactly Solvable Quantum Mechanical Potentials: An Alternative Approach.

    Science.gov (United States)

    Pronchik, Jeremy N.; Williams, Brian W.

    2003-01-01

    Describes an alternative approach to finding exactly solvable, one-dimensional quantum mechanical potentials. Differs from the usual approach in that instead of starting with a particular potential and seeking solutions to the related Schrodinger equations, it begins with known solutions to second-order ordinary differential equations and seeks to…

  4. Supersymmetric construction of exactly solvable potentials and nonlinear algebras

    International Nuclear Information System (INIS)

    Junker, G.; Roy, P.

    1998-01-01

    Using algebraic tools of supersymmetric quantum mechanics we construct classes of conditionally exactly solvable potentials being the supersymmetric partners of the linear or radial harmonic oscillator. With the help of the raising and lowering operators of these harmonic oscillators and the SUSY operators we construct ladder operators for these new conditionally solvable systems. It is found that these ladder operators together with the Hamilton operator form a nonlinear algebra which is of quadratic and cubic type for the SUSY partners of the linear and radial harmonic oscillator

  5. Parametric symmetries in exactly solvable real and PT symmetric complex potentials

    Energy Technology Data Exchange (ETDEWEB)

    Yadav, Rajesh Kumar, E-mail: rajeshastrophysics@gmail.com [Department of Physics, S. P. College, S K. M. University, Dumka 814101 (India); Khare, Avinash, E-mail: khare@physics.unipune.ac.in [Department of Physics, Savitribai Phule Pune University, Pune 411007 (India); Bagchi, Bijan, E-mail: bbagchi123@gmail.com [Department of Physics, School of Natural Science, Shiv Nadar University, Greater Noida, UP 201314 (India); Kumari, Nisha, E-mail: nishaism0086@gmail.com; Mandal, Bhabani Prasad, E-mail: bhabani.mandal@gmail.com [Department of Physics, Banaras Hindu University, Varanasi 221005 (India)

    2016-06-15

    In this paper, we discuss the parametric symmetries in different exactly solvable systems characterized by real or complex PT symmetric potentials. We focus our attention on the conventional potentials such as the generalized Pöschl Teller (GPT), Scarf-I, and PT symmetric Scarf-II which are invariant under certain parametric transformations. The resulting set of potentials is shown to yield a completely different behavior of the bound state solutions. Further, the supersymmetric partner potentials acquire different forms under such parametric transformations leading to new sets of exactly solvable real and PT symmetric complex potentials. These potentials are also observed to be shape invariant (SI) in nature. We subsequently take up a study of the newly discovered rationally extended SI potentials, corresponding to the above mentioned conventional potentials, whose bound state solutions are associated with the exceptional orthogonal polynomials (EOPs). We discuss the transformations of the corresponding Casimir operator employing the properties of the so(2, 1) algebra.

  6. Proton radioactivity with analytically solvable potential

    Indian Academy of Sciences (India)

    their heights at the touching distance. By varying the set of six parameters a variety of potentials can be generated and the versatile nature can account for various processes which renormalize the potential. The above potential has been used to calculate the half-lives of proton emitters with A = 105–171 using the exact.

  7. Proton radioactivity with analytically solvable potential

    Indian Academy of Sciences (India)

    barrier height should correspond to the Coulomb plus the centrifugal potentials. For. A = 105–171, the combined Coulomb and centrifugal potentials give rise to barriers of the order of 15 MeV [2]. But the earlier studies [13,14] show that inclusion of nuclear potential and various renormalization processes tend to reduce the ...

  8. Generalization of quasi-exactly solvable and isospectral potentials

    Indian Academy of Sciences (India)

    which are exactly solvable for single state. Here, we attain added realism and sophistication by dealing with higher dimensional Schrödinger equation so that the results can easily be applied to any required lower dimension (N > 1). Over and above, the dimensional variable N may be treated as a perturbation parameter (. 1.

  9. Band structure analysis of an analytically solvable Hill equation with continuous potential

    Science.gov (United States)

    Morozov, G. V.; Sprung, D. W. L.

    2015-03-01

    This paper concerns analytically solvable cases of Hill’s equation containing a continuously differentiable periodic potential. We outline a procedure for constructing the Floquet-Bloch fundamental system, and analyze the band structure of the system. The similarities to, and differences from, the cases of a piecewise constant periodic potential and the Mathieu potential, are illuminated.

  10. Application of quasiexactly solvable potential method to the N-body ...

    Indian Academy of Sciences (India)

    Abstract. The quasiexactly solvable potential method is used to determine the energies and the corresponding exact eigenfunctions for a system of N particles with equal mass interacting via an anharmonic potential. For systems with five and seven particles, we compute the ground state and the first excited state only, and ...

  11. The Lambert-W step-potential – an exactly solvable confluent hypergeometric potential

    Energy Technology Data Exchange (ETDEWEB)

    Ishkhanyan, A.M., E-mail: aishkhanyan@gmail.com [Institute for Physical Research, NAS of Armenia, 0203 Ashtarak (Armenia); Armenian State Pedagogical University, 0010 Yerevan (Armenia); Institute of Physics and Technology, National Research Tomsk Polytechnic University, Tomsk 634050 (Russian Federation)

    2016-02-15

    We present an asymmetric step–barrier potential for which the one-dimensional stationary Schrödinger equation is exactly solved in terms of the confluent hypergeometric functions. The potential is given in terms of the Lambert W-function, which is an implicitly elementary function also known as the product logarithm. We present the general solution of the problem and consider the quantum reflection at transmission of a particle above this potential barrier. Compared with the abrupt-step and hyperbolic tangent potentials, which are reproduced by the Lambert potential in certain parameter and/or variable variation regions, the reflection coefficient is smaller because of the lesser steepness of the potential on the particle incidence side. Presenting the derivation of the Lambert potential we show that this is a four-parametric sub-potential of a more general five-parametric one also solvable in terms of the confluent hypergeometric functions. The latter potential, however, is a conditionally integrable one. Finally, we show that there exists one more potential the solution for which is written in terms of the derivative of a bi-confluent Heun function. - Highlights: • We introduce an asymmetric step-barrier potential for which the 1D Schrödinger equation is exactly solved in terms of confluent hypergeometric functions. • The potential is given in terms of the Lambert-function, which is an implicitly elementary function also known as the product logarithm. • This is a four-parametric specification of a more general five-parametric potential also solvable in terms of the confluent hypergeometric functions. • There exists one more potential the solution for which is written in terms of the derivative of a bi-confluent Heun function.

  12. A conditionally exactly solvable generalization of the inverse square root potential

    Energy Technology Data Exchange (ETDEWEB)

    Ishkhanyan, A.M., E-mail: aishkhanyan@gmail.com [Institute for Physical Research, NAS of Armenia, Ashtarak 0203 (Armenia); Armenian State Pedagogical University, Yerevan 0010 (Armenia); Institute of Physics and Technology, National Research Tomsk Polytechnic University, Tomsk 634050 (Russian Federation)

    2016-11-25

    We present a conditionally exactly solvable singular potential for the one-dimensional Schrödinger equation which involves the exactly solvable inverse square root potential. Each of the two fundamental solutions that compose the general solution of the problem is given by a linear combination with non-constant coefficients of two confluent hypergeometric functions. Discussing the bound-state wave functions vanishing both at infinity and in the origin, we derive the exact equation for the energy spectrum which is written using two Hermite functions of non-integer order. In specific auxiliary variables this equation becomes a mathematical equation that does not refer to a specific physical context discussed. In the two-dimensional space of these auxiliary variables the roots of this equation draw a countable infinite set of open curves with hyperbolic asymptotes. We present an analytic description of these curves by a transcendental algebraic equation for the involved variables. The intersections of the curves thus constructed with a certain cubic curve provide a highly accurate description of the energy spectrum. - Highlights: • We present a conditionally exactly solvable singular potential for 1D Schrödinger equation. • Each of the two fundamental solutions is given by a linear combination with non-constant coefficients of two confluent hypergeometric functions. • The exact equation for the energy spectrum is written using two Hermite functions that do not reduce to polynomials.

  13. Generalization of quasi-exactly solvable and isospectral potentials

    Indian Academy of Sciences (India)

    Moreover, QES problem has its own inner mathematical beauty such as it can provide a good starting point for ... of their mathematical beauty like PT symmetry [21] and their application in differ- ent branches of physics ... studied problem and many authors proceed by using the standard central potential. U(r) in place of UN .

  14. One-dimensional Schrodinger equation with non-analytic potential V(x) = -g(2) exp (- vertical bar x vertical bar) and its exact Bessel-function solvability

    Czech Academy of Sciences Publication Activity Database

    Sasaki, R.; Znojil, Miloslav

    2016-01-01

    Roč. 49, č. 44 (2016), č. článku 445303. ISSN 1751-8113 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : non-analytic potentials * bound states * reflection and transmission * exactly solvable * orthogonality theorems * associated Hamiltonians * supersymmetry Subject RIV: BE - Theoretical Physics Impact factor: 1.857, year: 2016

  15. A position-dependent mass model for the Thomas–Fermi potential: Exact solvability and relation to δ-doped semiconductors

    International Nuclear Information System (INIS)

    Schulze-Halberg, Axel; García-Ravelo, Jesús; Pacheco-García, Christian; Juan Peña Gil, José

    2013-01-01

    We consider the Schrödinger equation in the Thomas–Fermi field, a model that has been used for describing electron systems in δ-doped semiconductors. It is shown that the problem becomes exactly-solvable if a particular effective (position-dependent) mass distribution is incorporated. Orthogonal sets of normalizable bound state solutions are constructed in explicit form, and the associated energies are determined. We compare our results with the corresponding findings on the constant-mass problem discussed by Ioriatti (1990) [13]. -- Highlights: ► We introduce an exactly solvable, position-dependent mass model for the Thomas–Fermi potential. ► Orthogonal sets of solutions to our model are constructed in closed form. ► Relation to delta-doped semiconductors is discussed. ► Explicit subband bottom energies are calculated and compared to results obtained in a previous study

  16. The quasi-exactly solvable potentials method applied to the three-body problem

    International Nuclear Information System (INIS)

    Chafa, F.; Chouchaoui, A.; Hachemane, M.; Ighezou, F.Z.

    2007-01-01

    The quasi-exactly solved potentials method is used to determine the energies and the corresponding exact eigenfunctions for three families of potentials playing an important role in the description of interactions occurring between three particles of equal mass. The obtained results may also be used as a test in evaluating the performance of numerical methods

  17. Quantum models with energy-dependent potentials solvable in terms of exceptional orthogonal polynomials

    Energy Technology Data Exchange (ETDEWEB)

    Schulze-Halberg, Axel, E-mail: axgeschu@iun.edu [Department of Mathematics and Actuarial Science, Indiana University Northwest, 3400 Broadway, Gary IN 46408 (United States); Department of Physics, Indiana University Northwest, 3400 Broadway, Gary IN 46408 (United States); Roy, Pinaki, E-mail: pinaki@isical.ac.in [Physics and Applied Mathematics Unit, Indian Statistical Institute, Kolkata 700108 (India)

    2017-03-15

    We construct energy-dependent potentials for which the Schrödinger equations admit solutions in terms of exceptional orthogonal polynomials. Our method of construction is based on certain point transformations, applied to the equations of exceptional Hermite, Jacobi and Laguerre polynomials. We present several examples of boundary-value problems with energy-dependent potentials that admit a discrete spectrum and the corresponding normalizable solutions in closed form.

  18. Quantum models with energy-dependent potentials solvable in terms of exceptional orthogonal polynomials

    International Nuclear Information System (INIS)

    Schulze-Halberg, Axel; Roy, Pinaki

    2017-01-01

    We construct energy-dependent potentials for which the Schrödinger equations admit solutions in terms of exceptional orthogonal polynomials. Our method of construction is based on certain point transformations, applied to the equations of exceptional Hermite, Jacobi and Laguerre polynomials. We present several examples of boundary-value problems with energy-dependent potentials that admit a discrete spectrum and the corresponding normalizable solutions in closed form.

  19. Quasi-exact solvability

    International Nuclear Information System (INIS)

    Ushveridze, A.G.

    1992-01-01

    This paper reports that quasi-exactly solvable (QES) models realize principally new type of exact solvability in quantum physics. These models are distinguished by the fact that the Schrodinger equations for them can be solved exactly only for certain limited parts of the spectrum, but not for the whole spectrum. They occupy an intermediate position between the exactly the authors solvable (ES) models and all the others. The number of energy levels for which the spectral problems can be solved exactly refer below to as the order of QES model. From the mathematical point of view the existence of QES models is not surprising. Indeed, if the term exact solvability expresses the possibility of total explicit diagonalization of infinite Hamiltonian matrix, then the term quasi-exact solvability implies the situation when the Hamiltonian matrix can be reduced explicitly to the block-diagonal form with one of the appearing blocks being finite

  20. Extrapolation of scattering data to the negative-energy region. II. Applicability of effective range functions within an exactly solvable model

    Science.gov (United States)

    Blokhintsev, L. D.; Kadyrov, A. S.; Mukhamedzhanov, A. M.; Savin, D. A.

    2018-02-01

    A problem of analytical continuation of scattering data to the negative-energy region to obtain information about bound states is discussed within an exactly solvable potential model. This work is continuation of the previous one by the same authors [L. D. Blokhintsev et al., Phys. Rev. C 95, 044618 (2017), 10.1103/PhysRevC.95.044618]. The goal of this paper is to determine the most effective way of analytic continuation for different systems. The d +α and α +12C systems are considered and, for comparison, an effective-range function approach and a recently suggested Δ method [O. L. Ramírez Suárez and J.-M. Sparenberg, Phys. Rev. C 96, 034601 (2017), 10.1103/PhysRevC.96.034601.] are applied. We conclude that the Δ method is more effective for heavier systems with large values of the Coulomb parameter, whereas for light systems with small values of the Coulomb parameter the effective-range function method might be preferable.

  1. Solvable models in quantum mechanics

    CERN Document Server

    Albeverio, S; Høegh-Krohn, R; Holden, H; Gesztesy, F

    2004-01-01

    This monograph presents a detailed study of a class of solvable models in quantum mechanics that describe the motion of a particle in a potential having support at the positions of a discrete (finite or infinite) set of point sources. Both situations-where the strengths of the sources and their locations are precisely known and where these are only known with a given probability distribution-are covered. The authors present a systematic mathematical approach to these models and illustrate its connections with previous heuristic derivations and computations. Results obtained by different method

  2. Class of exactly solvable scattering potentials in two dimensions, entangled-state pair generation, and a grazing-angle resonance effect

    Science.gov (United States)

    Loran, Farhang; Mostafazadeh, Ali

    2017-12-01

    We provide an exact solution of the scattering problem for the potentials of the form v (x ,y ) =χa(x ) [v0(x ) +v1(x ) ei α y] , where χa(x ) :=1 for x ∈[0 ,a ] , χa(x ) :=0 for x ∉[0 ,a ] , vj(x ) are real or complex-valued functions, χa(x ) v0(x ) is an exactly solvable scattering potential in one dimension, and α is a positive real parameter. If α exceeds the wave number k of the incident wave, the scattered wave does not depend on the choice of v1(x ) . In particular, v (x ,y ) is invisible if v0(x ) =0 and k α and v1(x ) ≠0 , the scattered wave consists of a finite number of coherent plane-wave pairs ψn± with wave vector: kn=(±√{k2-[nα ] 2 },n α ) , where n =0 ,1 ,2 ,...generating quantum states with a quantized component of momentum and pairs of states with an entangled momentum. We examine a realization of these potentials in terms of certain optical slabs. If k =N α for some positive integer N , ψN± coalesce and their amplitude diverge. If k exceeds N α slightly, ψN± have a much larger amplitude than ψn± with n

  3. Solvable stochastic dealer models for financial markets

    Science.gov (United States)

    Yamada, Kenta; Takayasu, Hideki; Ito, Takatoshi; Takayasu, Misako

    2009-05-01

    We introduce solvable stochastic dealer models, which can reproduce basic empirical laws of financial markets such as the power law of price change. Starting from the simplest model that is almost equivalent to a Poisson random noise generator, the model becomes fairly realistic by adding only two effects: the self-modulation of transaction intervals and a forecasting tendency, which uses a moving average of the latest market price changes. Based on the present microscopic model of markets, we find a quantitative relation with market potential forces, which have recently been discovered in the study of market price modeling based on random walks.

  4. The construction of finite solvable groups revisited

    OpenAIRE

    Eick, Bettina; Horn, Max

    2013-01-01

    We describe a new approach towards the systematic construction of finite groups up to isomorphism. This approach yields a practical algorithm for the construction of finite solvable groups up to isomorphism. We report on a GAP implementation of this method for finite solvable groups and exhibit some sample applications.

  5. On polynormality in finite solvable groups

    International Nuclear Information System (INIS)

    Mamadou Sadialiou Bah

    2003-05-01

    In the study of the arrangement of intermediate subgroups a wide use has been made of certain properties describing the way conjugacy classes of subgroups are embedded in the groups: abnormality, pronormality, paranormality, and their weak analogues. It was proved that pronormality and abnormality coincide with their weak analogues for solvable groups. This was a generalisation of known results of Peng and Taunt for finite solvable groups. In this paper we prove a conjecture of Borevich asserting a similar result for paranormality and polynormality (which is a sort of weak paranormality). Further we show that we get a stronger result when the given subgroup is nilpotent: In a finite solvable group any nilpotent polynormal subgroup is pronormal. (author)

  6. Exactly solvable relativistic model with the anomalous interaction

    Science.gov (United States)

    Ferraro, Elena; Messina, Antonino; Nikitin, A. G.

    2010-04-01

    A special class of Dirac-Pauli equations with time-like vector potentials of an external field is investigated. An exactly solvable relativistic model describing the anomalous interaction of a neutral Dirac fermion with a cylindrically symmetric external electromagnetic field is presented. The related external field is a superposition of the electric field generated by a charged infinite filament and the magnetic field generated by a straight line current. In the nonrelativistic approximation the considered model is reduced to the integrable Pron’ko-Stroganov model.

  7. Perturbations of normally solvable nonlinear operators, I

    Directory of Open Access Journals (Sweden)

    William O. Ray

    1985-01-01

    Full Text Available Let X and Y be Banach spaces and let ℱ and be Gateaux differentiable mappings from X to Y In this note we study when the operator ℱ+ is surjective for sufficiently small perturbations of a surjective operator ℱ The methods extend previous results in the area of normal solvability for nonlinear operators.

  8. General Reducibility and Solvability of Polynomial Equations ...

    African Journals Online (AJOL)

    General Reducibility and Solvability of Polynomial Equations. ... Unlike quadratic, cubic, and quartic polynomials, the general quintic and higher degree polynomials cannot be solved algebraically in terms of finite number of additions, ... Galois Theory, Solving Polynomial Systems, Polynomial factorization, Polynomial Ring ...

  9. Solvable groups and a shear construction

    DEFF Research Database (Denmark)

    Freibert, Marco; Swann, Andrew Francis

    The twist construction is a geometric model of T-duality that includes constructions of nilmanifolds from tori. This paper shows how one-dimensional foliations on manifolds may be used in a shear construction, which in algebraic form builds certain solvable Lie groups from Abelian ones. We discuss...... other examples of geometric structures that may be obtained from the shear construction....

  10. Exactly solvable models of baryon structure

    Energy Technology Data Exchange (ETDEWEB)

    Bijker, R. [Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico. Apartado Postal 70-543, 04510 Mexico D.F. (Mexico); Leviatan, A. [Racah Institute of Physics, The Hebrew University. Jerusalem 91904, Israel (Israel)

    1998-12-31

    We present a qualitative analysis of the gross features of baryon spectroscopy (masses and form factors) in terms of various exactly solvable models. It is shown that a collective model, in which baryon resonances are interpreted as rotations and vibrations of an oblate symmetric top, provides a good starting point for a more detailed quantitative study. (Author)

  11. Exactly solvable models of baryon structure

    International Nuclear Information System (INIS)

    Bijker, R.; Leviatan, A.

    1998-01-01

    We present a qualitative analysis of the gross features of baryon spectroscopy (masses and form factors) in terms of various exactly solvable models. It is shown that a collective model, in which baryon resonances are interpreted as rotations and vibrations of an oblate symmetric top, provides a good starting point for a more detailed quantitative study. (Author)

  12. Child abduction murder: the impact of forensic evidence on solvability.

    Science.gov (United States)

    Brown, Katherine M; Keppel, Robert D

    2012-03-01

    This study examined 733 child abduction murders (CAMs) occurring from 1968 to 2002 to explore the influence of forensic evidence on case solvability in CAM investigations. It was hypothesized that the presence of forensic evidence connecting the offender to the crime would enhance case solvability in murder investigations of abducted children. This study examined the impact of CAM of different types of forensic evidence and the impact of the summed total of forensic evidence items on case solvability by controlling for victim age, victim race, victim gender, and victim-offender relationship. Time and distance theoretical predictors were also included. Binomial logistic regression models were used to determine whether forensic evidence was a critical solvability factor in murder investigations of abducted children. This research indicated that, while forensic evidence increased case solvability, the impact of forensic evidence on solvability was not as important as other solvability factors examined. © 2011 American Academy of Forensic Sciences.

  13. Exactly solvable two-dimensional stationary Schrödinger operators obtained by the nonlocal Darboux transformation

    Energy Technology Data Exchange (ETDEWEB)

    Kudryavtsev, A.G., E-mail: kudryavtsev_a_g@mail.ru

    2013-11-15

    The Fokker–Planck equation associated with the two-dimensional stationary Schrödinger equation has the conservation law form that yields a pair of potential equations. The special form of Darboux transformation of the potential equations system is considered. As the potential variable is a nonlocal variable for the Schrödinger equation that provides the nonlocal Darboux transformation for the Schrödinger equation. This nonlocal transformation is applied for obtaining of the exactly solvable two-dimensional stationary Schrödinger equations. The examples of exactly solvable two-dimensional stationary Schrödinger operators with smooth potentials decaying at infinity are obtained.

  14. Solvable PT-symmetric Hamiltonians

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2002-01-01

    Roč. 65, č. 6 (2002), s. 1149-1151 ISSN 1063-7788 R&D Projects: GA AV ČR IAA1048004; GA AV ČR KSK1048102 Keywords : real energy-spectra * quantum-mechanics * anharmonic-oscillators * complex Hamiltonians * potentials * PJ * Eigenvalues * coulomb * model * well Subject RIV: BE - Theoretical Physics Impact factor: 0.533, year: 2002

  15. Reliability and extended-life potential of EBR-II

    International Nuclear Information System (INIS)

    King, R.W.

    1985-01-01

    Although the longlife potential of liquid-metal-cooled reactors (LMRs) has been only partially demonstrated, many factors point to the potential for exceptionally long life. EBR-II has the opportunity to become the first LMR to achieve an operational lifetime of 30 years or more. In 1984 a study of the extended-life potential of EBR-II identified the factors that contribute to the continued successful operation of EBR-II as a power reactor and experimental facility. Also identified were factors that could cause disruptions in the useful life of the facility. Although no factors were found that would inherently limit the life of EBR-II, measures were identified that could help ensure continued plant availability. These measures include the implementation of more effective surveillance, diagnostic, and control systems to complement the inherent safety and reliability features of EBR-II. An operating lifetime of well beyond 30 years is certainly feasible

  16. Complexification of three potential models – II

    Indian Academy of Sciences (India)

    . [1–10]. Few years ago, Bender and others [1,2,4,9] have looked at several complex potentials with PT symmetry and have shown that the energy eigenvalues are real when PT symmetry is unbroken, whereas they come in complex conjugate ...

  17. An exactly solvable system from quantum optics

    Energy Technology Data Exchange (ETDEWEB)

    Maciejewski, Andrzej J., E-mail: maciejka@astro.ia.uz.zgora.pl [J. Kepler Institute of Astronomy, University of Zielona Góra, Licealna 9, PL-65-417 Zielona Góra (Poland); Przybylska, Maria, E-mail: M.Przybylska@if.uz.zgora.pl [Institute of Physics, University of Zielona Góra, Licealna 9, 65-417 Zielona Góra (Poland); Stachowiak, Tomasz, E-mail: stachowiak@cft.edu.pl [Center for Theoretical Physics PAS, Al. Lotników 32/46, 02-668 Warsaw (Poland)

    2015-07-31

    We investigate a generalisation of the Rabi system in the Bargmann–Fock representation. In this representation the eigenproblem of the considered quantum model is described by a system of two linear differential equations with one independent variable. The system has only one irregular singular point at infinity. We show how the quantisation of the model is related to asymptotic behaviour of solutions in a vicinity of this point. The explicit formulae for the spectrum and eigenfunctions of the model follow from an analysis of the Stokes phenomenon. An interpretation of the obtained results in terms of differential Galois group of the system is also given. - Highlights: • New exactly solvable system from quantum optics is found. • Normalisation condition for system in Bargmann representation is used. • Formulae for spectrum and eigenfunctions from analysis of Stokes phenomenon are given.

  18. Exactly solvable models for multiatomic molecular Bose-Einstein condensates

    Energy Technology Data Exchange (ETDEWEB)

    Santos, G, E-mail: gfilho@if.ufrgs.br, E-mail: gfilho@cbpf.br [Instituto de Fisica da UFRGS, Av. Bento Goncalves, 9500, Agronomia, Porto Alegre, RS (Brazil)

    2011-08-26

    I introduce two families of exactly solvable models for multiatomic hetero-nuclear and homo-nuclear molecular Bose-Einstein condensates through the algebraic Bethe ansatz method. The conserved quantities of the respective models are also shown. (paper)

  19. Solvable nonlinear evolution PDEs in multidimensional space involving elliptic functions

    Energy Technology Data Exchange (ETDEWEB)

    Calogero, F [Dipartimento di Fisica, Universita di Roma ' La Sapienza' , 00185 Roma (Italy); Francoise, J-P [Laboratoire J-L Lions, UMR CNRS, Universite P-M Curie, Paris 6 (France); Sommacal, M [Dipartimento di Matematica e Informatica, Universita di Perugia, Perugia (Italy)

    2007-07-27

    A solvable nonlinear (system of) evolution PDEs in multidimensional space, involving elliptic functions, is identified, and certain of its solutions are exhibited. An isochronous version of this (system of) evolution PDEs in multidimensional space is also reported. (fast track communication)

  20. Solvable nonlinear evolution PDEs in multidimensional space involving trigonometric functions

    Energy Technology Data Exchange (ETDEWEB)

    Calogero, F [Dipartimento di Fisica, Universita di Roma ' La Sapienza' , 00185 Rome (Italy); Francoise, J-P [Laboratoire J.-L. Lions, UMR CNRS, Universite P.-M. Curie, Paris 6 (France); Sommacal, M [Dipartimento di Matematica e Informatica, Universita di Perugia (Italy)

    2007-05-04

    A solvable nonlinear (system of) evolution PDEs in multidimensional space, involving trigonometric (or hyperbolic) functions, is identified. An isochronous version of this (system of) evolution PDEs in multidimensional space is also reported. (fast track communication)

  1. On solvable spherical subgroups of semisimple algebraic groups (report version)

    OpenAIRE

    Avdeev, Roman

    2010-01-01

    A new approach to classification of solvable spherical subgroups of semisimple algebraic groups is considered. This approach is completely different from the known approach by D. Luna and provides an explicit classification.

  2. Analytical solutions for the radial Scarf II potential

    Science.gov (United States)

    Lévai, G.; Baran, Á.; Salamon, P.; Vertse, T.

    2017-06-01

    The real Scarf II potential is discussed as a radial problem. This potential has been studied extensively as a one-dimensional problem, and now these results are used to construct its bound and resonance solutions for l = 0 by setting the origin at some arbitrary value of the coordinate. The solutions with appropriate boundary conditions are composed as the linear combination of the two independent solutions of the Schrödinger equation. The asymptotic expression of these solutions is used to construct the S0 (k)s-wave S-matrix, the poles of which supply the k values corresponding to the bound, resonance and anti-bound solutions. The location of the discrete energy eigenvalues is analyzed, and the relation of the solutions of the radial and one-dimensional Scarf II potentials is discussed. It is shown that the generalized Woods-Saxon potential can be generated from the Rosen-Morse II potential in the same way as the radial Scarf II potential is obtained from its one-dimensional correspondent. Based on this analogy, possible applications are also pointed out.

  3. Multichannel coupling with supersymmetric quantum mechanics and exactly-solvable model for the Feshbach resonance

    International Nuclear Information System (INIS)

    Sparenberg, Jean-Marc; Samsonov, Boris F; Foucart, Francois; Baye, Daniel

    2006-01-01

    A new type of supersymmetric transformations of the coupled-channel radial Schroedinger equation is introduced, which do not conserve the vanishing behaviour of solutions at the origin. Contrary to the usual transformations, these 'non-conservative' transformations allow, in the presence of thresholds, the construction of well-behaved potentials with coupled scattering matrices from uncoupled potentials. As an example, an exactly-solvable potential matrix is obtained which provides a very simple model of the Feshbach-resonance phenomenon. (letter to the editor)

  4. Quasi exactly solvable operators and abstract associative algebras

    International Nuclear Information System (INIS)

    Brihaye, Y.; Kosinski, P.

    1998-01-01

    We consider the vector spaces consisting of direct sums of polynomials of given degrees and we show how to classify the linear differential operators preserving these spaces. The families of operators so obtained are identified as the envelopping algebras of particular abstract associative algebras. Some of these operators can be transformed into quasi exactly solvable Schroedinger operators which, having a hidden algebra, can be partially solved algebraically; we exhibit however a series of Schoedinger equations which, while completely solvable algebraically, do not possess a hidden algebra

  5. Solvable quantum lattices with nonlocal non-Hermitian endpoint interactions

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2015-01-01

    Roč. 361, OCT (2015), s. 226-246 ISSN 0003-4916 Institutional support: RVO:61389005 Keywords : exactly solvable quantum models * non-Hermitian boundary conditions * new nonlocal boundary conditions * physical inner products Subject RIV: BE - Theoretical Physics Impact factor: 2.375, year: 2015

  6. Solvable Model for Dynamic Mass Transport in Disordered Geophysical Media

    KAUST Repository

    Marder, M.

    2018-03-29

    We present an analytically solvable model for transport in geophysical materials on large length and time scales. It describes the flow of gas to a complicated absorbing boundary over long periods of time. We find a solution to this model using Green\\'s function techniques, and apply the solution to three absorbing networks of increasing complexity.

  7. Conjugacy class sizes and solvability of finite groups

    Indian Academy of Sciences (India)

    Let be a finite group and * be the set of primary, biprimary and triprimary elements of . We prove that if the conjugacy class sizes of * are {1,,,} with positive coprime integers and ,then is solvable. This extends a recent result of Kong (Manatsh. Math. 168(2)(2012) 267–271).

  8. Analytically solvable models of reaction-diffusion systems

    Energy Technology Data Exchange (ETDEWEB)

    Zemskov, E P; Kassner, K [Institut fuer Theoretische Physik, Otto-von-Guericke-Universitaet, Universitaetsplatz 2, 39106 Magdeburg (Germany)

    2004-05-01

    We consider a class of analytically solvable models of reaction-diffusion systems. An analytical treatment is possible because the nonlinear reaction term is approximated by a piecewise linear function. As particular examples we choose front and pulse solutions to illustrate the matching procedure in the one-dimensional case.

  9. Classification of non-solvable groups with a given property

    Indian Academy of Sciences (India)

    In this paper, we classify the finite non-solvable groups satisfying the following property P 5 : their orders of representatives are set-wise relatively prime for any 5 distinct non-central conjugacy classes. Author Affiliations. Zeinab Foruzanfar1 Zohreh Mostaghim1. School of Mathematics, Iran University of Science and ...

  10. Classification of non-solvable groups with a given property

    Indian Academy of Sciences (India)

    In this paper, we classify the finite non-solvable groups satisfying the following property P5: their orders of representatives are set-wise relatively prime for any 5 distinct non-central conjugacy classes. Keywords. Conjugacy classes; graph; Frobenius group; order. 2010 Mathematics Subject Classification. 20D60, 20E45. 1.

  11. WEAK SOLVABILITY FOR A CLASS OF CONTACT PROBLEMS

    Directory of Open Access Journals (Sweden)

    Andaluzia Matei

    2010-07-01

    Full Text Available A unilateral frictionless contact model, under the small deformationshypothesis, for static processes is considered. We model the behaviorof the material by a constitutive law stated in a subdifferentialform. The contact is described with Signorini's condition. Our studyfocuses on the weak solvability of the model, based on a weak formulation with dual Lagrange multipliers

  12. The Asymmetric Simple Exclusion Process: An Exactly Solvable ...

    Indian Academy of Sciences (India)

    Arvind Ayyer, Indian Institute of Science

    2017-06-30

    Jun 30, 2017 ... An Exactly Solvable Model of Particle Transport. Arvind Ayyer,. Indian Institute of Science. 28th Mid Year Meeting. Faculty Hall, Indian Institute of Science ... System is in thermodynamic equilibrium. Microscopic motion may be present, but macroscopic observables do not change over time. The probability ...

  13. Three-body problem in d-dimensional space: Ground state, (quasi)-exact-solvability

    Science.gov (United States)

    Turbiner, Alexander V.; Miller, Willard; Escobar-Ruiz, M. A.

    2018-02-01

    As a straightforward generalization and extension of our previous paper [A. V. Turbiner et al., "Three-body problem in 3D space: Ground state, (quasi)-exact-solvability," J. Phys. A: Math. Theor. 50, 215201 (2017)], we study the aspects of the quantum and classical dynamics of a 3-body system with equal masses, each body with d degrees of freedom, with interaction depending only on mutual (relative) distances. The study is restricted to solutions in the space of relative motion which are functions of mutual (relative) distances only. It is shown that the ground state (and some other states) in the quantum case and the planar trajectories (which are in the interaction plane) in the classical case are of this type. The quantum (and classical) Hamiltonian for which these states are eigenfunctions is derived. It corresponds to a three-dimensional quantum particle moving in a curved space with special d-dimension-independent metric in a certain d-dependent singular potential, while at d = 1, it elegantly degenerates to a two-dimensional particle moving in flat space. It admits a description in terms of pure geometrical characteristics of the interaction triangle which is defined by the three relative distances. The kinetic energy of the system is d-independent; it has a hidden sl(4, R) Lie (Poisson) algebra structure, alternatively, the hidden algebra h(3) typical for the H3 Calogero model as in the d = 3 case. We find an exactly solvable three-body S3-permutationally invariant, generalized harmonic oscillator-type potential as well as a quasi-exactly solvable three-body sextic polynomial type potential with singular terms. For both models, an extra first order integral exists. For d = 1, the whole family of 3-body (two-dimensional) Calogero-Moser-Sutherland systems as well as the Tremblay-Turbiner-Winternitz model is reproduced. It is shown that a straightforward generalization of the 3-body (rational) Calogero model to d > 1 leads to two primitive quasi

  14. Ruthenium(II) Complexes as Potential Apoptosis Inducers in Chemotherapy.

    Science.gov (United States)

    Zheng, Kangdi; Wu, Qiong; Wang, Chengxi; Tan, Weijun; Mei, Wenjie

    2017-01-01

    Herein, the development of ruthenium complexes as potential apoptosis inducers, as well as their underlying mechanism has been reviewed. In recent years, various ruthenium complexes have been designed and their in vitro and in vivo inhibitory activities against various types of tumor cells have been evaluated extensively. It's demonstrated that ruthenium complexes can induce apoptosis of tumor cells through the signal pathway of mitochondria-mediated, death receptor-mediated, and/or endoplasmic reticulum (ER) stress pathways. Alternately, the binding behavior of these ruthenium(II) complexes with DNA, especially with Gquadruplex DNA may play a key role in the DNA damage of tumor cells, and thus provides a versatile tool to rational design novel ruthenium complexes with high activity and selectivity.

  15. Higgs potential in the type II seesaw model

    International Nuclear Information System (INIS)

    Arhrib, A.; Benbrik, R.; Chabab, M.; Rahili, L.; Ramadan, J.; Moultaka, G.; Peyranere, M. C.

    2011-01-01

    The standard model Higgs sector, extended by one weak gauge triplet of scalar fields with a very small vacuum expectation value, is a very promising setting to account for neutrino masses through the so-called type II seesaw mechanism. In this paper we consider the general renormalizable doublet/triplet Higgs potential of this model. We perform a detailed study of its main dynamical features that depend on five dimensionless couplings and two mass parameters after spontaneous symmetry breaking, and highlight the implications for the Higgs phenomenology. In particular, we determine (i) the complete set of tree-level unitarity constraints on the couplings of the potential and (ii) the exact tree-level boundedness from below constraints on these couplings, valid for all directions. When combined, these constraints delineate precisely the theoretically allowed parameter space domain within our perturbative approximation. Among the seven physical Higgs states of this model, the mass of the lighter (heavier) CP even state h 0 (H 0 ) will always satisfy a theoretical upper (lower) bound that is reached for a critical value μ c of μ (the mass parameter controlling triple couplings among the doublet/triplet Higgses). Saturating the unitarity bounds, we find an upper bound m h 0 or approx. μ c and μ c . In the first regime the Higgs sector is typically very heavy, and only h 0 that becomes SM-like could be accessible to the LHC. In contrast, in the second regime, somewhat overlooked in the literature, most of the Higgs sector is light. In particular, the heaviest state H 0 becomes SM-like, the lighter states being the CP odd Higgs, the (doubly) charged Higgses, and a decoupled h 0 , possibly leading to a distinctive phenomenology at the colliders.

  16. Exactly solvable models in many-body theory

    CERN Document Server

    March, N H

    2016-01-01

    The book reviews several theoretical, mostly exactly solvable, models for selected systems in condensed states of matter, including the solid, liquid, and disordered states, and for systems of few or many bodies, both with boson, fermion, or anyon statistics. Some attention is devoted to models for quantum liquids, including superconductors and superfluids. Open problems in relativistic fields and quantum gravity are also briefly reviewed.The book ranges almost comprehensively, but concisely, across several fields of theoretical physics of matter at various degrees of correlation and at different energy scales, with relevance to molecular, solid-state, and liquid-state physics, as well as to phase transitions, particularly for quantum liquids. Mostly exactly solvable models are presented, with attention also to their numerical approximation and, of course, to their relevance for experiments.

  17. Exactly solvable models for atom-molecule Hamiltonians.

    Science.gov (United States)

    Dukelsky, J; Dussel, G G; Esebbag, C; Pittel, S

    2004-07-30

    We present a family of exactly solvable generalizations of the Jaynes-Cummings model involving the interaction of an ensemble of SU(2) or SU(1,1) quasispins with a single boson field. They are obtained from the trigonometric Richardson-Gaudin models by replacing one of the SU(2) or SU(1,1) degrees of freedom by an ideal boson. The application to a system of bosonic atoms and molecules is reported.

  18. New analytically solvable models of relativistic point interactions

    International Nuclear Information System (INIS)

    Gesztesy, F.; Seba, P.

    1987-01-01

    Two new analytically solvable models of relativistic point interactions in one dimension (being natural extensions of the nonrelativistic δ-resp, δ'-interaction) are considered. Their spectral properties in the case of finitely many point interactions as well as in the periodic case are fully analyzed. Moreover the spectrum is explicitely determined in the case of independent, identically distributed random coupling constants and the analog of the Saxon and Huther conjecture concerning gaps in the energy spectrum of such systems is derived

  19. Exactly solvable models of proton and neutron interacting bosons

    International Nuclear Information System (INIS)

    Lerma, S.H.; Errea, B.; Dukelsky, J.; Pittel, S.; Van Isacker, P.

    2006-01-01

    We describe a class of exactly-solvable models of interacting bosons based on the algebra SO(3, 2). Each copy of the algebra represents a system of neutron and proton bosons in a given bosonic level interacting via a pairing interaction. The model that includes s and d bosons is a specific realization of the IBM2, restricted to the transition regime between vibrational and γ-soft nuclei. By including additional copies of the algebra, we can generate proton-neutron boson models involving other boson degrees of freedom, while still maintaining exact solvability. In each of these models, we can study not only the states of maximal symmetry, but also those of mixed symmetry, albeit still in the vibrational to γ-soft transition regime. Furthermore, in each of these models we can study some features of F-spin symmetry breaking. We report systematic calculations as a function of the pairing strength for models based on s,d, and g bosons and on s,d, and f bosons. The formalism of exactly-solvable models based on the SO(3, 2) algebra is not limited to systems of proton and neutron bosons, however, but can also be applied to other scenarios that involve two species of interacting bosons

  20. Equivalence Problem Solvability in Biparametric Gateway Program Models

    Directory of Open Access Journals (Sweden)

    A. E. Molchanov

    2014-01-01

    Full Text Available Algebraic program models with procedures are designed to analyze program semantic properties on their models called program schemes. Procedural liberisation problem and equivalence problem are stated for program models with procedures in which both defining parameters are chosen independently. Program models with procedures built over a given program model without procedures are investigated. Algorithms for both stated tasks are proposed for models where an additional restriction is applied: the intersection emptiness problem is solvable in the program model without procedures. Polynomial estimates for the complexity of the algorithms are shown. Some topics for further investigation are proposed.

  1. Quantum transfer matrices for discrete and continuous quasi-exactly solvable problems

    International Nuclear Information System (INIS)

    Zabrodin, A.V.

    1995-01-01

    The algebraic structure of continuous and discrete quasi-exactly solvable spectral problems by embedding them into the framework of the quantum inverse scattering method is clarified. The quasi-exactly solvable Hamiltonians in one dimension are identified with traces of quantum monodromy matrices for specific integrable systems with non-periodic boundary conditions. Applications to Azbel-Hofstadter problem are outlined. 39 refs

  2. Re-modeling Chara action potential: II. The action potential form under salinity stress

    Directory of Open Access Journals (Sweden)

    Mary Jane Beilby

    2017-04-01

    Full Text Available In part I we established Thiel-Beilby model of the Chara action potential (AP. In part II the AP is investigated in detail at the time of saline stress. Even very short exposure of salt-sensitive Chara cells to artificial pond water with 50 mM NaCl (Saline APW modified the AP threshold and drastically altered the AP form. Detailed modeling of 14 saline APs from 3 cells established that both the Ca2+ pump and the Ca2+ channels on internal stores seem to be affected, with the changes sometimes cancelling and sometimes re-enforcing each other, leading to APs with long durations and very complex forms. The exposure to salinity offers further insights into AP mechanism and suggests future experiments. The prolonged APs lead to greater loss of chloride and potassium ions, compounding the effects of saline stress.

  3. Exactly solvable string models of curved space-time backgrounds

    International Nuclear Information System (INIS)

    Russo, J.G.

    1995-01-01

    We consider a new 3-parameter class of exact 4-dimensional solutions in closed string theory and solve the corresponding string model, determining the physical spectrum and the partition function. The background fields (4-metric, antisymmetric tensor, two Kaluza-Klein vector fields, dilaton and modulus) generically describe axially symmetric stationary rotating (electro)magnetic flux-tube type universes. Backgrounds of this class include both the ''dilatonic'' (a=1) and ''Kaluza-Klein'' (a=√(3)) Melvin solutions and the uniform magnetic field solution, as well as some singular space-times. Solvability of the string σ-model is related to its connection via duality to a simpler model which is a ''twisted'' product of a flat 2-space and a space dual to 2-plane. We discuss some physical properties of this model (tachyonic instabilities in the spectrum, gyromagnetic ratio, issue of singularities, etc.). It provides one of the first examples of a consistent solvable conformal string model with explicit D=4 curved space-time interpretation. (orig.)

  4. Exactly solvable model in quadrupole-octupole coupled states

    Science.gov (United States)

    Jalili Majarshin, A.; Sabri, H.; Rezaei, M.

    2018-03-01

    Exactly solvable model in quadrupole-octupole coupled (QOC) states is an interesting nuclear structure phenomenon. For example, several transitions of the electric dipole and quadrupole (E1 and E2) values are indicative of QOC states. Various collective models as three-level and four-level pairing models were employed in order to account for the observed properties of the QOC states. We suggest a simultaneous description of low-lying collective positive and negative-parity states to use the spdf and sdf interacting boson model to reproduce the general characteristics of the QOC states. Also, quantum phase transitions are investigated based on dual algebraic structures for the sd, sdf and spdf-IBM. The low lying positive and negative parity states and the QOC properties of the stable even-even Cd isotopes are calculated in solvable extended transitional Hamiltonian of the IBM-spdf and IBM-sdf models based on the affine SU (1 , 1) ˆ Lie algebra. Some observables such as energy levels, transition rates, expectation value of boson number operators, energy differences and staggering pattern are calculated and examined for Cd isotopes. The IBM calculations indicate a nuclear structure of the electric E1, E2 and E3 strength and energy spectra in the low-lying, thus confirming the experimental results for transition region. The calculations confirm a good agreement for the energy spectra, quantum phase transitions and fragmentation of the E1, E2 and E3 strengths.

  5. SUSY formalism for the symmetric double well potential

    Indian Academy of Sciences (India)

    symmetric double well potential barrier we have obtained a class of exactly solvable potentials subject to moving boundary condition. The eigenstates are also obtained by the same technique. Keywords. SUSY; moving boundary condition; exactly solvable; symmetric double well; NH3 molecule. PACS Nos 02.30.Ik; 03.50.

  6. Synthesis and structure of copper(II) complexes: Potential cyanide ...

    Indian Academy of Sciences (India)

    ing the oxidase models. The necessity to make progress in developing copper oxidase models requires synthesis of appropriate copper complexes to rationalize the func- tions of such oxidases unequivocally.46–52 Therefore, to study the coordination chemistry of Cu(II) incorpo- rating the new azo ligands,53 HLa and HLb, ...

  7. Bound states emerging from below the continuum in a solvable PT -symmetric discrete Schrödinger equation

    Science.gov (United States)

    Znojil, Miloslav

    2017-07-01

    The phenomenon of the birth of an isolated quantum bound state at the lower edge of the continuum is studied for a particle moving along a discrete real line of coordinates x ∈Z . The motion is controlled by a weakly nonlocal 2 J -parametric external potential V which is non-Hermitian but P T symmetric. The model is found exactly solvable. The bound states are interpreted as Sturmians. Their closed-form definitions are presented and discussed up to J =7 .

  8. Exactly solvable string models of curved space-time backgrounds

    CERN Document Server

    Russo, J.G.; Russo, J G; Tseytlin, A A

    1995-01-01

    We consider a new 3-parameter class of exact 4-dimensional solutions in closed string theory and solve the corresponding string model, determining the physical spectrum and the partition function. The background fields (4-metric, antisymmetric tensor, two Kaluza-Klein vector fields, dilaton and modulus) generically describe axially symmetric stationary rotating (electro)magnetic flux-tube type universes. Backgrounds of this class include both the dilatonic Melvin solution and the uniform magnetic field solution discussed earlier as well as some singular space-times. Solvability of the string sigma model is related to its connection via duality to a much simpler looking model which is a "twisted" product of a flat 2-space and a space dual to 2-plane. We discuss some physical properties of this model as well as a number of generalizations leading to larger classes of exact 4-dimensional string solutions.

  9. Protecting coherence by environmental decoherence: a solvable paradigmatic model

    Science.gov (United States)

    Torres, Juan Mauricio; Seligman, Thomas H.

    2017-11-01

    We consider a particularly simple exactly solvable model for a qubit coupled to sequentially nested environments. The purpose is to exemplify the coherence conserving effect of a central system, that has been reported as a result of increasing the coupling between near and far environment. The paradigmatic example is the Jaynes–Cummings Hamiltonian, which we introduce into a Kossakowski–Lindblad master equation using alternatively the lowering operator of the oscillator or its number operator as Lindblad operators. The harmonic oscillator is regarded as the near environment of the qubit, while effects of a far environment are accounted for by the two options for the dissipative part of the master equation. The exact solution allows us to cover the entire range of coupling strength from the perturbative regime to strong coupling analytically. The coherence conserving effect of the coupling to the far environment is confirmed throughout.

  10. An Exactly Solvable Supersymmetric Model of Semimagic Nuclei

    International Nuclear Information System (INIS)

    Balantekin, A. B.; Gueven, Nurtac; Pehlivan, Yamac

    2008-01-01

    A simple model of nucleons coupled to angular momentum zero (s-pairs) occupying the valance shell of a semi-magic nuclei is considered. The model has a separable, orbit dependent pairing interaction which dominates over the kinetic term. It is shown that such an interaction leads to an exactly solvable model whose (0 + ) eigenstates and energies can be computed very easily with the help of the algebraic Bethe ansatz method. It is also shown that the model has a supersymmetry which connects the spectra of some semimagic nuclei. The results obtained from this model for the semimagic Ni isotopes from 58 Ni to 68 Ni are given. In addition, a new and easier technique for calculating the energy eigenvalues from the Bethe ansatz equations is also presented.

  11. Quantum quench dynamics in analytically solvable one-dimensional models

    Science.gov (United States)

    Iucci, Anibal; Cazalilla, Miguel A.; Giamarchi, Thierry

    2008-03-01

    In connection with experiments in cold atomic systems, we consider the non-equilibrium dynamics of some analytically solvable one-dimensional systems which undergo a quantum quench. In this quench one or several of the parameters of the Hamiltonian of an interacting quantum system are changed over a very short time scale. In particular, we concentrate on the Luttinger model and the sine-Gordon model in the Luther-Emery point. For the latter, we show that the order parameter and the two-point correlation function relax in the long time limit to the values determined by a generalized Gibbs ensemble first discussed by J. T. Jaynes [Phys. Rev. 106, 620 (1957); 108, 171 (1957)], and recently conjectured by M. Rigol et.al. [Phys. Rev. Lett. 98, 050405 (2007)] to apply to the non-equilibrium dynamics of integrable systems.

  12. Solvable Family of Driven-Dissipative Many-Body Systems

    Science.gov (United States)

    Foss-Feig, Michael; Young, Jeremy T.; Albert, Victor V.; Gorshkov, Alexey V.; Maghrebi, Mohammad F.

    2017-11-01

    Exactly solvable models have played an important role in establishing the sophisticated modern understanding of equilibrium many-body physics. Conversely, the relative scarcity of solutions for nonequilibrium models greatly limits our understanding of systems away from thermal equilibrium. We study a family of nonequilibrium models, some of which can be viewed as dissipative analogues of the transverse-field Ising model, in that an effectively classical Hamiltonian is frustrated by dissipative processes that drive the system toward states that do not commute with the Hamiltonian. Surprisingly, a broad and experimentally relevant subset of these models can be solved efficiently. We leverage these solutions to compute the effects of decoherence on a canonical trapped-ion-based quantum computation architecture, and to prove a no-go theorem on steady-state phase transitions in a many-body model that can be realized naturally with Rydberg atoms or trapped ions.

  13. Topological order in an exactly solvable 3D spin model

    International Nuclear Information System (INIS)

    Bravyi, Sergey; Leemhuis, Bernhard; Terhal, Barbara M.

    2011-01-01

    Research highlights: RHtriangle We study exactly solvable spin model with six-qubit nearest neighbor interactions on a 3D face centered cubic lattice. RHtriangle The ground space of the model exhibits topological quantum order. RHtriangle Elementary excitations can be geometrically described as the corners of rectangular-shaped membranes. RHtriangle The ground space can encode 4g qubits where g is the greatest common divisor of the lattice dimensions. RHtriangle Logical operators acting on the encoded qubits are described in terms of closed strings and closed membranes. - Abstract: We study a 3D generalization of the toric code model introduced recently by Chamon. This is an exactly solvable spin model with six-qubit nearest-neighbor interactions on an FCC lattice whose ground space exhibits topological quantum order. The elementary excitations of this model which we call monopoles can be geometrically described as the corners of rectangular-shaped membranes. We prove that the creation of an isolated monopole separated from other monopoles by a distance R requires an operator acting on Ω(R 2 ) qubits. Composite particles that consist of two monopoles (dipoles) and four monopoles (quadrupoles) can be described as end-points of strings. The peculiar feature of the model is that dipole-type strings are rigid, that is, such strings must be aligned with face-diagonals of the lattice. For periodic boundary conditions the ground space can encode 4g qubits where g is the greatest common divisor of the lattice dimensions. We describe a complete set of logical operators acting on the encoded qubits in terms of closed strings and closed membranes.

  14. Potential Clinical Implications of the Urotensin II Receptor Antagonists

    Directory of Open Access Journals (Sweden)

    Emilie Kane

    2011-07-01

    Full Text Available Urotensin-II (UII, which binds to its receptor UT, plays an important role in the heart, kidneys, pancreas, adrenal gland and CNS. In the vasculature, it acts as a potent endothelium-independent vasoconstrictor and endothelium-dependent vasodilator. In disease states, this constriction-dilation equilibrium is disrupted. There is an upregulation of the UII system in heart disease, metabolic syndrome and kidney failure. The increase in UII release and UT expression suggest that UII system may be implicated in the pathology and pathogenesis of these diseases by causing an increase in ACAT-1 activity leading to SMC proliferation and foam cell infiltration, insulin resistance (DMII, as well as inflammation, high blood pressure and plaque formation. Recently, UT antagonists such as SB-611812, palosuran, and most recently a piperazino-isoindolinone based antagonist have been developed in the hope of better understanding the UII system and treating its associated diseases.

  15. Flatland Position-Dependent-Mass: Polar Coordinates, Separability and Exact Solvability

    Science.gov (United States)

    Mazharimousavi, S. Habib; Mustafa, Omar

    2010-10-01

    The kinetic energy operator with position-dependent-mass in plane polar coordinates is obtained. The separability of the corresponding Schrödinger equation is discussed. A hypothetical toy model is reported and two exactly solvable examples are studied.

  16. Non-solvable contractions of semisimple Lie algebras in low dimension

    International Nuclear Information System (INIS)

    Campoamor-Stursberg, R

    2007-01-01

    The problem of non-solvable contractions of Lie algebras is analysed. By means of a stability theorem, the problem is shown to be deeply related to the embeddings among semisimple Lie algebras and the resulting branching rules for representations. With this procedure, we determine all deformations of indecomposable Lie algebras having a nontrivial Levi decomposition onto semisimple Lie algebras of dimension n ≤ 8, and obtain the non-solvable contractions of the latter class of algebras

  17. PREFACE: Singular interactions in quantum mechanics: solvable models

    Science.gov (United States)

    Dell'Antonio, Gianfausto; Exner, Pavel; Geyler, Vladimir

    2005-06-01

    This issue comprises two dozen research papers which are all in one sense or another devoted to models in which the interaction is singular and sharply localized; a typical example is a quantum particle interacting with a family of δ-type potentials. Such an idealization usually makes analysis of their properties considerably easier, sometimes allowing us to reduce it to a simple algebraic problem—this is why one speaks about solvable models. The subject can be traced back to the early days of quantum mechanics; however, the progress in this field was slow and uneven until the 1960s, mostly because singular interactions are often difficult to deal with mathematically and intuitive arguments do not work. After overcoming the initial difficulties the `classical' theory of point interactions was developed, and finally summarized in 1988 in a monograph by Albeverio, Gesztesy, Høegh-Krohn, and Holden, which you will find quoted in numerous places within this issue. A reliable way to judge theories is to observe the progress they make within one or two decades. In this case there is no doubt that the field has witnessed a continuous development and covered areas which nobody had thought of when the subject first emerged. The reader may see it in the second edition of the aforementioned book which was published by AMS Chelsea only recently and contained a brief survey of these new achievements. It is no coincidence that this topical issue appears at the same time; it has been conceived as its counterpart and a forum at which fresh results in the field can demonstrated. Let us briefly survey the contents of the issue. While the papers included have in common the basic subject, they represent a broad spectrum philosophically as well as technically, and any attempt to classify them is somewhat futile. Nevertheless, we will divide them into a few groups. The first comprises contributions directly related to the usual point-interaction ideology. M Correggi and one of the

  18. Topological order in an exactly solvable 3D spin model

    Science.gov (United States)

    Bravyi, Sergey; Leemhuis, Bernhard; Terhal, Barbara M.

    2011-04-01

    We study a 3D generalization of the toric code model introduced recently by Chamon. This is an exactly solvable spin model with six-qubit nearest-neighbor interactions on an FCC lattice whose ground space exhibits topological quantum order. The elementary excitations of this model which we call monopoles can be geometrically described as the corners of rectangular-shaped membranes. We prove that the creation of an isolated monopole separated from other monopoles by a distance R requires an operator acting on Ω( R2) qubits. Composite particles that consist of two monopoles (dipoles) and four monopoles (quadrupoles) can be described as end-points of strings. The peculiar feature of the model is that dipole-type strings are rigid, that is, such strings must be aligned with face-diagonals of the lattice. For periodic boundary conditions the ground space can encode 4 g qubits where g is the greatest common divisor of the lattice dimensions. We describe a complete set of logical operators acting on the encoded qubits in terms of closed strings and closed membranes.

  19. An exactly solvable, spatial model of mutation accumulation in cancer

    Science.gov (United States)

    Paterson, Chay; Nowak, Martin A.; Waclaw, Bartlomiej

    2016-12-01

    One of the hallmarks of cancer is the accumulation of driver mutations which increase the net reproductive rate of cancer cells and allow them to spread. This process has been studied in mathematical models of well mixed populations, and in computer simulations of three-dimensional spatial models. But the computational complexity of these more realistic, spatial models makes it difficult to simulate realistically large and clinically detectable solid tumours. Here we describe an exactly solvable mathematical model of a tumour featuring replication, mutation and local migration of cancer cells. The model predicts a quasi-exponential growth of large tumours, even if different fragments of the tumour grow sub-exponentially due to nutrient and space limitations. The model reproduces clinically observed tumour growth times using biologically plausible rates for cell birth, death, and migration rates. We also show that the expected number of accumulated driver mutations increases exponentially in time if the average fitness gain per driver is constant, and that it reaches a plateau if the gains decrease over time. We discuss the realism of the underlying assumptions and possible extensions of the model.

  20. Entanglement, decoherence and thermal relaxation in exactly solvable models

    International Nuclear Information System (INIS)

    Lychkovskiy, Oleg

    2011-01-01

    Exactly solvable models provide an opportunity to study different aspects of reduced quantum dynamics in detail. We consider the reduced dynamics of a single spin in finite XX and XY spin 1/2 chains. First we introduce a general expression describing the evolution of the reduced density matrix. This expression proves to be tractable when the combined closed system (i.e. open system plus environment) is integrable. Then we focus on comparing decoherence and thermalization timescales in the XX chain. We find that for a single spin these timescales are comparable, in contrast to what should be expected for a macroscopic body. This indicates that the process of quantum relaxation of a system with few accessible states can not be separated in two distinct stages - decoherence and thermalization. Finally, we turn to finite-size effects in the time evolution of a single spin in the XY chain. We observe three consecutive stages of the evolution: regular evolution, partial revivals, irregular (apparently chaotic) evolution. The duration of the regular stage is proportional to the number of spins in the chain. We observe a 'quiet and cold period' in the end of the regular stage, which breaks up abruptly at some threshold time.

  1. Another New Solvable Many-Body Model of Goldfish Type

    Directory of Open Access Journals (Sweden)

    Francesco Calogero

    2012-07-01

    Full Text Available A new solvable many-body problem is identified. It is characterized by nonlinear Newtonian equations of motion (''acceleration equal force'' featuring one-body and two-body velocity-dependent forces ''of goldfish type'' which determine the motion ofan arbitrary number $N$ of unit-mass point-particles in a plane. The $N$ (generally complex values $z_{n}(t$ at time $t$ ofthe $N$ coordinates of these moving particles are given by the $N$eigenvalues of a time-dependent $Nimes N$ matrix $U(t$explicitly known in terms of the $2N$ initial data $z_{n}(0$and $dot{z}_{n}(0 $. This model comes in two dif/ferentvariants, one featuring 3 arbitrary coupling constants, the other only 2; for special values of these parameters all solutions are completely periodic with the same period independent of the initial data (''isochrony''; for other special values of these parameters this property holds up to corrections vanishing exponentially as $tightarrow infty$ (''asymptotic isochrony''. Other isochronous variants of these models are also reported. Alternative formulations, obtained by changing the dependent variables from the $N$ zeros of a monic polynomial of degree $N$ to its $N$ coefficients, are also exhibited. Some mathematical findings implied by some of these results - such as Diophantine properties of the zeros of certain polynomials - are outlined, but their analysis is postponed to a separate paper.

  2. A Bethe ansatz solvable model for superpositions of Cooper pairs and condensed molecular bosons

    Energy Technology Data Exchange (ETDEWEB)

    Hibberd, K.E. [Centre for Mathematical Physics, University of Queensland, 4072 (Australia); Dunning, C. [Institute of Mathematics, Statistics and Actuarial Science, University of Kent (United Kingdom); Links, J. [Centre for Mathematical Physics, University of Queensland, 4072 (Australia)]. E-mail: jrl@maths.uq.edu.au

    2006-08-07

    We introduce a general Hamiltonian describing coherent superpositions of Cooper pairs and condensed molecular bosons. For particular choices of the coupling parameters, the model is integrable. One integrable manifold, as well as the Bethe ansatz solution, was found by Dukelsky et al. [J. Dukelsky, G.G. Dussel, C. Esebbag, S. Pittel, Phys. Rev. Lett. 93 (2004) 050403]. Here we show that there is a second integrable manifold, established using the boundary quantum inverse scattering method. In this manner we obtain the exact solution by means of the algebraic Bethe ansatz. In the case where the Cooper pair energies are degenerate we examine the relationship between the spectrum of these integrable Hamiltonians and the quasi-exactly solvable spectrum of particular Schrodinger operators. For the solution we derive here the potential of the Schrodinger operator is given in terms of hyperbolic functions. For the solution derived by Dukelsky et al., loc. cit. the potential is sextic and the wavefunctions obey PT-symmetric boundary conditions. This latter case provides a novel example of an integrable Hermitian Hamiltonian acting on a Fock space whose states map into a Hilbert space of PT-symmetric wavefunctions defined on a contour in the complex plane.

  3. A Bethe ansatz solvable model for superpositions of Cooper pairs and condensed molecular bosons

    Science.gov (United States)

    Hibberd, K. E.; Dunning, C.; Links, J.

    2006-08-01

    We introduce a general Hamiltonian describing coherent superpositions of Cooper pairs and condensed molecular bosons. For particular choices of the coupling parameters, the model is integrable. One integrable manifold, as well as the Bethe ansatz solution, was found by Dukelsky et al. [J. Dukelsky, G.G. Dussel, C. Esebbag, S. Pittel, Phys. Rev. Lett. 93 (2004) 050403]. Here we show that there is a second integrable manifold, established using the boundary quantum inverse scattering method. In this manner we obtain the exact solution by means of the algebraic Bethe ansatz. In the case where the Cooper pair energies are degenerate we examine the relationship between the spectrum of these integrable Hamiltonians and the quasi-exactly solvable spectrum of particular Schrödinger operators. For the solution we derive here the potential of the Schrödinger operator is given in terms of hyperbolic functions. For the solution derived by Dukelsky et al., loc. cit. the potential is sextic and the wavefunctions obey PT-symmetric boundary conditions. This latter case provides a novel example of an integrable Hermitian Hamiltonian acting on a Fock space whose states map into a Hilbert space of PT-symmetric wavefunctions defined on a contour in the complex plane.

  4. A Bethe ansatz solvable model for superpositions of Cooper pairs and condensed molecular bosons

    International Nuclear Information System (INIS)

    Hibberd, K.E.; Dunning, C.; Links, J.

    2006-01-01

    We introduce a general Hamiltonian describing coherent superpositions of Cooper pairs and condensed molecular bosons. For particular choices of the coupling parameters, the model is integrable. One integrable manifold, as well as the Bethe ansatz solution, was found by Dukelsky et al. [J. Dukelsky, G.G. Dussel, C. Esebbag, S. Pittel, Phys. Rev. Lett. 93 (2004) 050403]. Here we show that there is a second integrable manifold, established using the boundary quantum inverse scattering method. In this manner we obtain the exact solution by means of the algebraic Bethe ansatz. In the case where the Cooper pair energies are degenerate we examine the relationship between the spectrum of these integrable Hamiltonians and the quasi-exactly solvable spectrum of particular Schrodinger operators. For the solution we derive here the potential of the Schrodinger operator is given in terms of hyperbolic functions. For the solution derived by Dukelsky et al., loc. cit. the potential is sextic and the wavefunctions obey PT-symmetric boundary conditions. This latter case provides a novel example of an integrable Hermitian Hamiltonian acting on a Fock space whose states map into a Hilbert space of PT-symmetric wavefunctions defined on a contour in the complex plane

  5. Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity

    Directory of Open Access Journals (Sweden)

    Mostafa Wanees Ahmed El husseny

    2017-01-01

    Full Text Available Adipokines are bioactive molecules that regulate several physiological functions such as energy balance, insulin sensitization, appetite regulation, inflammatory response, and vascular homeostasis. They include proinflammatory cytokines such as adipocyte fatty acid binding protein (A-FABP and anti-inflammatory cytokines such as adiponectin, as well as vasodilator and vasoconstrictor molecules. In obesity and type II diabetes mellitus (DM, insulin resistance causes impairment of the endocrine function of the perivascular adipose tissue, an imbalance in the secretion of vasoconstrictor and vasodilator molecules, and an increased production of reactive oxygen species. Recent studies have shown that targeting plasma levels of adipokines or the expression of their receptors can increase insulin sensitivity, improve vascular function, and reduce the risk of cardiovascular morbidity and mortality. Several reviews have discussed the potential of adipokines as therapeutic targets for type II DM and obesity; however, this review is the first to focus on their therapeutic potential for vascular dysfunction in type II DM and obesity.

  6. Generalized Wronskian relations one dimensional Schroedinger equation and nonlinear partial differential equations solvable by the inverse scattering method

    International Nuclear Information System (INIS)

    Calogero, F.

    1976-01-01

    A generalized Wronskian type relation is used to obtain a number of expressions for the scattering and bound state parameters (reflection and transmission coefficients, bound state energies and normalization constants) in the context of the one dimensional Schroedinger equation. These expressions are in the form of integrals over the wave functions multiplied by appropriate (generally nonlinear) combinations of the potentials and their derivatives. Some of them provide the basis for deriving classes of nonlinear partial differential equations that are solvable by the inverse scattering method. The main interest of this approach rests in its simplicity and in its delivery of nonlinear evolution equations that may involve more than one (space) variable and contain coefficients that are not constant

  7. On the Solvability of 2-pair Unicast Networks --- A Cut-based Characterization

    OpenAIRE

    Cai, K.; Letaief, K. B.; Fan, P.; Feng, R.

    2010-01-01

    In this paper, we propose a subnetwork decomposition/combination approach to investigate the single rate $2$-pair unicast problem. It is shown that the solvability of a $2$-pair unicast problem is completely determined by four specific link subsets, namely, $\\mathcal A_{1,1}$, $\\mathcal A_{2,2}$, $\\mathcal A_{1,2}$ and $\\mathcal A_{2,1}$ of its underlying network. As a result, an efficient cut-based algorithm to determine the solvability of a $2$-pair unicast problem is presented.

  8. Calculation of the magnetic vector potential in the TJ-II

    International Nuclear Information System (INIS)

    Lopez Fraguas, A.; Lopez Bruna, D.; Romero, J. A.

    2005-01-01

    The properties of the vector magnetic potential and its usefulness to calculate magnetic fluxes in both stationary and time-dependent conditions are p revised in this report. We have adapted to the TJ-II Flexible Heliac efficient numerical expressions to calculate the vector potential, calculating in addition the magnetic flux with this formalism in circumstances whose complexity makes very convenient the use of the vector potential. The result on induced voltages offer theoretical support to the measurements of induced voltage due to the OH coils in the plasma, like the measurements provided by the loop voltage diagnostic installed in the TJ-II, as well as to the cylindrical approximation of the plasma often used to interpret experimental data. (Author) 11 refs

  9. Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.

    Science.gov (United States)

    Lauinger, Ina L; Vivas, Livia; Perozzo, Remo; Stairiker, Christopher; Tarun, Alice; Zloh, Mire; Zhang, Xujie; Xu, Hua; Tonge, Peter J; Franzblau, Scott G; Pham, Duc-Hung; Esguerra, Camila V; Crawford, Alexander D; Maes, Louis; Tasdemir, Deniz

    2013-06-28

    Chemicals targeting the liver stage (LS) of the malaria parasite are useful for causal prophylaxis of malaria. In this study, four lichen metabolites, evernic acid (1), vulpic acid (2), psoromic acid (3), and (+)-usnic acid (4), were evaluated against LS parasites of Plasmodium berghei. Inhibition of P. falciparum blood stage (BS) parasites was also assessed to determine stage specificity. Compound 4 displayed the highest LS activity and stage specificity (LS IC50 value 2.3 μM, BS IC50 value 47.3 μM). The compounds 1-3 inhibited one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for LS activity. To determine species specificity and to clarify the mechanism of reported antibacterial effects, 1-4 were also evaluated against FabI homologues and whole cells of various pathogens (S. aureus, E. coli, M. tuberculosis). Molecular modeling studies suggest that lichen acids act indirectly via binding to allosteric sites on the protein surface of the FAS-II enzymes. Potential toxicity of compounds was assessed in human hepatocyte and cancer cells (in vitro) as well as in a zebrafish model (in vivo). This study indicates the therapeutic and prophylactic potential of lichen metabolites as antibacterial and antiplasmodial agents.

  10. Adsorption potential of mercury(II) from aqueous solutions onto Romanian peat moss.

    Science.gov (United States)

    Bulgariu, Laura; Ratoi, Mioara; Bulgariu, Dumitru; Macoveanu, Matei

    2009-06-01

    This study was undertaken to evaluate the adsorption potential of Romanian peat moss for the removal of mercury(II) from aqueous solutions. The batch system experiments carried out showed that this natural material was effective in removing mercury(II). The analysis of FT-IR spectra indicated that the mechanism involved in the adsorption can be mainly attributed to the binding of mercury(II) with the carboxylic groups of Romanian peat moss. Adsorption equilibrium approached within 60 min. The adsorption data fitted well the Langmuir isotherm model. The maximum adsorption capacity (qmax) was 98.94 mg g(-1). Pseudo-second-order kinetic model was applicable to the adsorption data. The thermodynamic parameters indicate that the adsorption process was spontaneous as the Gibbs free energy values were found to be negative (between -17.58 and -27.25 kJ mol(-1)) at the temperature range of 6-54 degrees C.

  11. Proteomic peptide scan of porphyromonas gingivalis fima type ii for searching potential b-cell epitopes

    Science.gov (United States)

    LUCCHESE, A.; GUIDA, A.; CAPONE, G.; DONNARUMMA, G.; LAINO, L.; PETRUZZI, M.; SERPICO, R.; SILVESTRE, F.; GARGARI, M.

    2016-01-01

    SUMMARY Purpose To identify potential antigenic targets for Porphyromonas gingivalis vaccine development. Materials and methods In the present study, we analyzed the Porphyromonas gingivalis, fimA type II primary amino acid sequence and characterized the similarity to the human proteome at the pentapeptide level. Results We found that exact peptide-peptide profiling of the fimbrial antigen versus the human proteome shows that only 19 out of 344 fimA type II pentapeptides are uniquely owned by the bacterial protein. Conclusions The concept that protein immunogenicity is allocated in rare peptide sequences and the search the Porphyromonas gingivalis fimA type II sequence for peptides unique to the bacterial protein and absent in the human host, might be used in new therapeutical approaches as a significant adjunct to current periodontal therapies. PMID:28042435

  12. Exactly solvable models for tri-atomic molecular Bose-Einstein condensates

    Energy Technology Data Exchange (ETDEWEB)

    Santos, G; Roditi, I; Santos, Z V T [CBPF-Centro Brasileiro de Pesquisas Fisicas, Rio de Janeiro RJ (Brazil); Foerster, A [Instituto de Fisica da UFRGS, Porto Alegre, RS (Brazil); Tonel, A P [CCET da Universidade Federal do Pampa/Unipampa, Bage, RS (Brazil)], E-mail: gfilho@cbpf.br

    2008-07-25

    We construct a family of tri-atomic models for heteronuclear and homonuclear molecular Bose-Einstein condensates. We show that these new generalized models are exactly solvable through the algebraic Bethe ansatz method and derive their corresponding Bethe ansatz equations and energies.

  13. Exactly solvable models for triatomic-molecular Bose-Einstein Condensates

    Energy Technology Data Exchange (ETDEWEB)

    Santos, G.; Roditi, I.; Santos, Z.V.T. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil); Foerster, A. [Instituto de Fisica da UFRGS, Porto Alegre, RS (Brazil); Tonel, A.P. [CCET da Universidade Federal do Pampa/Unipampa, Bage, RS (Brazil)

    2014-11-15

    We construct a family of triatomic models for heteronuclear and homonuclear molecular Bose-Einstein condensates. We show that these new generalized models are exactly solvable through the algebraic Bethe Ansatz method and derive their corresponding Bethe Ansatz equations and energies. (author)

  14. Interaction of attosecond electromagnetic pulses with atoms: The exactly solvable model

    International Nuclear Information System (INIS)

    Popov, Yu. V.; Kouzakov, K. A.; Vinitsky, S. I.; Gusev, A. A.

    2007-01-01

    We consider the exactly solvable model of interaction of zero-duration electromagnetic pulses with an atom. The model has a number of peculiar properties which are outlined in the cases of a single pulse and two opposite pulses. In perspective, it can be useful in different fields of physics involving interaction of attosecond laser pulses with quantum systems

  15. Solvability condition for synchronization of discrete-time multi-agent systems and design

    NARCIS (Netherlands)

    Stoorvogel, Antonie Arij; Saberi, Ali; Zhang, Meirong; Liu, Zhenwei

    This paper provides solvability conditions for state synchronization with homogeneous discrete-time multi-agent systems (MAS) with a directed and weighted communication network under full-state coupling. We assume only a lower bound for the second eigenvalue of the Laplacian matrices associated with

  16. Flatland Position-Dependent-Mass: Polar Coordinates, Separability and Exact Solvability

    Directory of Open Access Journals (Sweden)

    Omar Mustafa

    2010-10-01

    Full Text Available The kinetic energy operator with position-dependent-mass in plane polar coordinates is obtained. The separability of the corresponding Schrödinger equation is discussed. A hypothetical toy model is reported and two exactly solvable examples are studied.

  17. Hierarchy of exactly solvable spin-1/2 chains with so (N)_I critical points

    NARCIS (Netherlands)

    Lahtinen, V.; Mansson, T.; Ardonne, E.

    2014-01-01

    We construct a hierarchy of exactly solvable spin-1/2 chains with so(N)1 critical points. Our construction is based on the framework of condensate-induced transitions between topological phases. We employ this framework to construct a Hamiltonian term that couples N transverse field Ising chains

  18. On non-Frattini chief factors and solvability of finite groups

    Indian Academy of Sciences (India)

    Indian Acad. Sci. (Math. Sci.) Vol. 122, No. 2, May 2012, pp. 163–173. c Indian Academy of Sciences. On non-Frattini chief factors and solvability of finite groups. JIANJUN LIU1,∗. , XIUYUN GUO2 and QIANLU LI3. 1School of Mathematics and Statistics, Southwest University,. Chongqing 400715, People's Republic of China.

  19. An approach to one-dimensional elliptic quasi-exactly solvable models

    Indian Academy of Sciences (India)

    Abstract. One-dimensional Jacobian elliptic quasi-exactly solvable second-order differ- ential equations are obtained by introducing the generalized third master functions. It is shown that the solutions of these differential equations are generating functions for a new set of polynomials in terms of energy with factorization ...

  20. Exactly solvable model of phase transition between hadron and quark-gluon-matter

    International Nuclear Information System (INIS)

    Gorenstein, M.I.; Petrov, V.K.; Shelest, V.P.; Zinovjev, G.M.

    1982-01-01

    An exactly solvable model of phase transition between hadron and quark-gluon matter is proposed. The hadron phase of this model is considered as a gas of bags filled by point massless constituents. The mass and volume spectrum of the bag is found. The thermodynamical characteristics of a bag gas in the neighbourhood of a phase transition point are ascertained in analytical form

  1. BPM Breakdown Potential in the PEP-II B-factory Storage Ring Collider

    Energy Technology Data Exchange (ETDEWEB)

    Weathersby, Stephen; Novokhatski, Alexander; /SLAC

    2010-02-10

    High current B-Factory BPM designs incorporate a button type electrode which introduces a small gap between the button and the beam chamber. For achievable currents and bunch lengths, simulations indicate that electric potentials can be induced in this gap which are comparable to the breakdown voltage. This study characterizes beam induced voltages in the existing PEP-II storage ring collider BPM as a function of bunch length and beam current.

  2. Spacecraft potential control aboard Equator-S as a test for Cluster-II

    Directory of Open Access Journals (Sweden)

    K. Torkar

    1999-12-01

    Full Text Available The payload of Equator-S was complemented by the potential control device (PCD to stabilise the electric potential of the spacecraft with respect to the ambient plasma. Low potentials are essential for accurate measurements of the thermal plasma. The design of PCD is inherited from instruments for Geotail and Cluster and utilises liquid metal ion sources generating a beam of indium ions at several keV. The set-up of the instrument and its interaction with the plasma instruments on board is presented. When the instrument was switched on during commissioning, unexpectedly high ignition and operating voltages of some ion emitters were observed. An extensive investigation was initiated and the results, which lead to an improved design for Cluster-II, are summarised. The cause of the abnormal behaviour could be linked to surface contamination of some emitters, which will be monitored and cured by on-board procedures in future. The mission operations on Equator-S were not at all affected, because of the high redundancy built into the instrument so that a sufficient number of perfectly operating emitters were available and were turned on routinely throughout the mission. Observations of the effect of spacecraft potential control on the plasma remained limited to just one event on January 8, 1998, which is analysed in detail. It is concluded that the ion beam lead to the predicted improvement of the particle measurements even outside the low density regions of the magnetosphere where the effect of spacecraft potential control would have been much more pronounced, and that the similar instruments for the four Cluster-II spacecraft to be launched in 2000 will be very important to ensure accurate plasma data from this mission.Key words. Space plasma physics (active perturbation experiments; spacecraft sheaths · wakes · charging; instruments and techniques

  3. Investigating solvability and complexity of linear active networks by means of matroids

    DEFF Research Database (Denmark)

    Petersen, Bjørn

    1979-01-01

    The solvability and complexity problems of finear active network are approached from a purely combinatorial point of view, using the concepts of matroid theory. Since the method is purely combinatorial, we take into account the network topology alone. Under this assumption necessary and sufficient...... conditions are given for the unique solvablity of linear active networks. The complexity and the number of dc-eigenfrequencies are also given. The method enables.you to decide if degeneracies are due to the topology alone, or if they are caused by special relations among network parameter values....... If the network parameter values are taken into account, the complexity and number of dc-eigenfrequencies given by the method, are only upper and lower bounds, respectively. The above conditions are fairly easily checked, and the complexity and number of dc-elgenfrequencies are found, using polynomially bounded...

  4. Hydrodynamics at the smallest scales: a solvability criterion for Navier-Stokes equations in high dimensions.

    Science.gov (United States)

    Viswanathan, T M; Viswanathan, G M

    2011-01-28

    Strong global solvability is difficult to prove for high-dimensional hydrodynamic systems because of the complex interplay between nonlinearity and scale invariance. We define the Ladyzhenskaya-Lions exponent α(L)(n)=(2+n)/4 for Navier-Stokes equations with dissipation -(-Δ)(α) in R(n), for all n≥2. We review the proof of strong global solvability when α≥α(L)(n), given smooth initial data. If the corresponding Euler equations for n>2 were to allow uncontrolled growth of the enstrophy (1/2)∥∇u∥(L²)(2), then no globally controlled coercive quantity is currently known to exist that can regularize solutions of the Navier-Stokes equations for α<α(L)(n). The energy is critical under scale transformations only for α=α(L)(n).

  5. [Solvability of mental health care in the Family Health Strategy: social representation of professionals and users].

    Science.gov (United States)

    Jorge, Maria Salete Bessa; Vasconcelos, Mardênia Gomes Ferreira; Junior, Euton Freitas de Castro; Barreto, Levi Alves; Rosa, Lianna Ramalho de Sena; de Lima, Leilson Lira

    2014-12-01

    To aprehend the social representations about the solvability in mental health care with users of the Family Health Strategy and professionals of family health teams and of the Center for Psychosocial Care. A qualitative study using semi-structured interviews for data collection, and the Alceste software for analysis. This software uses the Hierarchical Descending Classification based on the examination of lexical roots, considering the words as units and providing context in the corpus. The representations emerge in two opposing poles: the users require satisfaction with care and the professionals realize the need for improvement of health actions. Although the matricial support in mental health and the home visits are developed, the barriers related to investment in health, continuing education and organization of care persist. The different representations enable improvements in customer service, solvability of care and aggregate knowledge and practices in the expanded perspective of health needs in the family, social and therapeutic context.


  6. Topological Galois theory solvability and unsolvability of equations in finite terms

    CERN Document Server

    Khovanskii, Askold

    2014-01-01

    This book provides a detailed and largely self-contained description of various classical and new results on solvability and unsolvability of equations in explicit form. In particular, it offers a complete exposition of the relatively new area of topological Galois theory, initiated by the author. Applications of Galois theory to solvability of algebraic equations by radicals, basics of Picard–Vessiot theory, and Liouville's results on the class of functions representable by quadratures are also discussed. A unique feature of this book is that recent results are presented in the same elementary manner as classical Galois theory, which will make the book useful and interesting to readers with varied backgrounds in mathematics, from undergraduate students to researchers. In this English-language edition, extra material has been added (Appendices A–D), the last two of which were written jointly with Yura Burda.

  7. Solvability in the sense of sequences to some non-Fredholm operators

    Directory of Open Access Journals (Sweden)

    Vitaly Volpert

    2013-07-01

    Full Text Available We study the solvability of certain linear nonhomogeneous elliptic problems and show that under reasonable technical conditions the convergence in $L^2(mathbb{R}^d$ of their right sides implies the existence and the convergence in $H^2(mathbb{R}^d$ of the solutions. The equations involve second order differential operators without Fredholm property and we use the methods of spectral and scattering theory for Schrodinger type operators analogously to our preceding work [17].

  8. Number-phase entropic uncertainty relations and Wigner functions for solvable quantum systems with discrete spectra

    Energy Technology Data Exchange (ETDEWEB)

    Honarasa, G.R., E-mail: honarasa@sutech.ac.i [Atomic and Molecular Group, Faculty of Physics, Yazd University, Yazd (Iran, Islamic Republic of); Tavassoly, M.K., E-mail: mktavassoly@yazduni.ac.i [Atomic and Molecular Group, Faculty of Physics, Yazd University, Yazd (Iran, Islamic Republic of); Hatami, M., E-mail: mhatami@yazduni.ac.i [Atomic and Molecular Group, Faculty of Physics, Yazd University, Yazd (Iran, Islamic Republic of)

    2009-10-19

    In this Letter, the 'number-phase entropic uncertainty relation' and the 'number-phase Wigner function' of generalized coherent states associated to a few solvable quantum systems with non-degenerate spectra are studied. We also investigate time evolution of 'number-phase entropic uncertainty' and 'Wigner function' of the considered physical systems with the help of temporally stable Gazeau-Klauder coherent states.

  9. Well-solvable cases of the QAP with block-structured matrices

    OpenAIRE

    Çela, E; Deineko, VG; Woeginger, GJ Gerhard

    2014-01-01

    We investigate special cases of the quadratic assignment problem (QAP) where one of the two underlying matrices carries a simple block structure. For the special case where the second underlying matrix is a monotone anti-Monge matrix, we derive a polynomial time result for a certain class of cut problems. For the special case where the second underlying matrix is a product matrix, we identify two sets of conditions on the block structure that make this QAP polynomially solvable respectively N...

  10. Unitary-matrix models as exactly solvable string theories

    Science.gov (United States)

    Periwal, Vipul; Shevitz, Danny

    1990-01-01

    Exact differential equations are presently found for the scaling functions of models of unitary matrices which are solved in a double-scaling limit, using orthogonal polynomials on a circle. For the case of the simplest, k = 1 model, the Painleve II equation with constant 0 is obtained; possible nonperturbative phase transitions exist for these models. Equations are presented for k = 2 and 3, and discussed with a view to asymptotic behavior.

  11. Statistical mechanics and dynamics of solvable models with long-range interactions

    International Nuclear Information System (INIS)

    Campa, Alessandro; Dauxois, Thierry; Ruffo, Stefano

    2009-01-01

    For systems with long-range interactions, the two-body potential decays at large distances as V(r)∼1/r α , with α≤d, where d is the space dimension. Examples are: gravitational systems, two-dimensional hydrodynamics, two-dimensional elasticity, charged and dipolar systems. Although such systems can be made extensive, they are intrinsically non additive: the sum of the energies of macroscopic subsystems is not equal to the energy of the whole system. Moreover, the space of accessible macroscopic thermodynamic parameters might be non convex. The violation of these two basic properties of the thermodynamics of short-range systems is at the origin of ensemble inequivalence. In turn, this inequivalence implies that specific heat can be negative in the microcanonical ensemble, and temperature jumps can appear at microcanonical first order phase transitions. The lack of convexity allows us to easily spot regions of parameter space where ergodicity may be broken. Historically, negative specific heat had been found for gravitational systems and was thought to be a specific property of a system for which the existence of standard equilibrium statistical mechanics itself was doubted. Realizing that such properties may be present for a wider class of systems has renewed the interest in long-range interactions. Here, we present a comprehensive review of the recent advances on the statistical mechanics and out-of-equilibrium dynamics of solvable systems with long-range interactions. The core of the review consists in the detailed presentation of the concept of ensemble inequivalence, as exemplified by the exact solution, in the microcanonical and canonical ensembles, of mean-field type models. Remarkably, the entropy of all these models can be obtained using the method of large deviations. Long-range interacting systems display an extremely slow relaxation towards thermodynamic equilibrium and, what is more striking, the convergence towards quasi-stationary states. The

  12. Deuteron form factors and e-d polarization observables for the Paris and Graz-II potentials

    International Nuclear Information System (INIS)

    Schwarz, K.; Plessas, W.; Mathelitsch, L.

    1983-01-01

    Elastic e-d scattering is studied employing the meson-theoretical Paris potential and the non-local separable Graz-II potential. Electric and magnetic form factors are calculated with inclusion of meson-exchange currents and compared to existing experimental data. Deuteron vector and tensor polarizations are predicted and discussed in relation to the deuteron wave functions of the potential models considered. Thereby the off-shell behaviour of the Graz-II interaction is found to be close to that one of the Paris potential over the most important domain of low and moderate off-shell moments. (Author)

  13. On a class of solvable Pauli-Schroedinger hamiltonians

    Energy Technology Data Exchange (ETDEWEB)

    Codriansky, S. [Instituto Venezolano de Investigaciones Cientificas, Caracas (Venezuela). Centro de Fisica]|[Instituto Pedagogico, Caracas (Venezuela). Dept. de Matematicas y Fisica; Cordero, P. [Chile Univ., Santiago (Chile). Dept. de Fisica; Salamo, S. [Universidad Simon Bolivar, Caracas (Venezuela). Dept. of Physics

    1995-12-01

    To every scalar potential for which the bound state problem of the Schroedinger equation can be (at least partially) solved it is possible to associate a new potential containing Pauli matrices and for which the associated Pauli-Schroedinger equation can also be solved to the same extent. The new system can be regarded as a finite break of the supersymmetry that the original system and its supersymmetric partner have. (orig.)

  14. Symmetrized quartic polynomial oscillators and their partial exact solvability

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2016-01-01

    Roč. 380, č. 16 (2016), s. 1414-1418 ISSN 0375-9601 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : Quantum bound states * Non-numerical methods * Piecewise analytic potentials * Quartic oscillators * Quasi-extact states Subject RIV: BE - Theoretical Physics Impact factor: 1.772, year: 2016

  15. Solvable Model of a Generic Trapped Mixture of Interacting Bosons: Many-Body and Mean-Field Properties

    Science.gov (United States)

    Klaiman, S.; Streltsov, A. I.; Alon, O. E.

    2018-04-01

    A solvable model of a generic trapped bosonic mixture, N 1 bosons of mass m 1 and N 2 bosons of mass m 2 trapped in an harmonic potential of frequency ω and interacting by harmonic inter-particle interactions of strengths λ 1, λ 2, and λ 12, is discussed. It has recently been shown for the ground state [J. Phys. A 50, 295002 (2017)] that in the infinite-particle limit, when the interaction parameters λ 1(N 1 ‑ 1), λ 2(N 2 ‑ 1), λ 12 N 1, λ 12 N 2 are held fixed, each of the species is 100% condensed and its density per particle as well as the total energy per particle are given by the solution of the coupled Gross-Pitaevskii equations of the mixture. In the present work we investigate properties of the trapped generic mixture at the infinite-particle limit, and find differences between the many-body and mean-field descriptions of the mixture, despite each species being 100%. We compute analytically and analyze, both for the mixture and for each species, the center-of-mass position and momentum variances, their uncertainty product, the angular-momentum variance, as well as the overlap of the exact and Gross-Pitaevskii wavefunctions of the mixture. The results obtained in this work can be considered as a step forward in characterizing how important are many-body effects in a fully condensed trapped bosonic mixture at the infinite-particle limit.

  16. Calculation of the magnetic vector potential in the TJ-II; Calculo del Potencial Magnetico Vector en el TJ-II

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Fraguas, A.; Lopez Bruna, D.; Romero, J. A.

    2005-07-01

    The properties of the vector magnetic potential and its usefulness to calculate magnetic fluxes in both stationary and time-dependent conditions are p revised in this report. We have adapted to the TJ-II Flexible Heliac efficient numerical expressions to calculate the vector potential, calculating in addition the magnetic flux with this formalism in circumstances whose complexity makes very convenient the use of the vector potential. The result on induced voltages offer theoretical support to the measurements of induced voltage due to the OH coils in the plasma, like the measurements provided by the loop voltage diagnostic installed in the TJ-II, as well as to the cylindrical approximation of the plasma often used to interpret experimental data. (Author) 11 refs.

  17. Quasi-exactly solvable models in quantum mechanics

    International Nuclear Information System (INIS)

    Montemayor, R.; Salem, L.D.

    1990-01-01

    An extension of the application range of a method that studies partial resolution in quantum mechanics and that is based on the Ricatti equation, is carried out through adequately defined mappings. As an example of the use of these mappings, new families of Morse and Poeschl-Teller potentials are identified. A detailed discussion is made of their characteristics and the solutions obtained. (Author). 3 refs

  18. Fractional distillation as a strategy for reducing the genotoxic potential of SRC-II coal liquids: a status report

    Energy Technology Data Exchange (ETDEWEB)

    Pelroy, R.A.; Wilson, B.W.

    1981-09-01

    This report presents results of studies on the effects of fractional distillation on the genotoxic potential of Solvent Refined Coal (SRC-II) liquids. SRC-II source materials and distilled liquids were provided by Pittsburg and Midway Coal Mining Co. Fractional distillations were conducted on products from the P-99 process development unit operating under conditions approximating those anticipated at the SRC-II demonstration facility. Distillation cuts were subjected to chemical fractionation, in vitro bioassay and initial chemical analysis. Findings are discussed as they relate to the temperature at which various distillate cuts were produced. This document is the first of two status reports scheduled for 1981 describing these studies.

  19. MHC-II MARKER POTENTIAL LINKED TO MOTILE AEROMONAD SEPTICAEMIA DISEASE RESISTANCE IN AFRICAN CATFISH (Clarias gariepinus

    Directory of Open Access Journals (Sweden)

    Rommy Suprapto

    2017-09-01

    Full Text Available One of the important issues in catfish farming is motile aeromonad septicaemia (MAS disease caused by the bacterium Aeromonas hydrophila. This study aimed to find the MHC-II marker potential for marker-based selection to generate MAS disease resistance of African catfish. PCR method was applied to identify catfish (body length: 7-8 cm population that have MHC-II marker. Fish with and without the marker were then challenged by intraperitonially injecting of 0.1 mL/fish with A. hydrophila (105 cfu/mL. The results showed that the survival of fish having MHC-II marker (77.50 ± 4.00% was higher than that of fish without the marker (53.33 ± 4.77%. Fish carrying MHC-II marker fish has also higher total erythrocytes, total leukocytes, phagocytic activity, and hematocrit levels than that of fish without the marker. The PCR results using specific primer for MHC-II showed a specific DNA band of 426 bp in fish having the marker, while there were no DNA bands in fish without the marker. Results of the PCR analyses showed that the percentage of progenies carrying MHC-II marker was 80%, while progenies from broodstock without the marker was 0%; this indicated that MHC-II marker could be inherited to the offsprings. Thus, the MHC-II marker could be used as a molecular marker of MAS disease resistance catfish.

  20. Mathematical aspects of an exactly solvable inflationary model

    Science.gov (United States)

    Pintus, N.; Mignemi, S.

    2018-01-01

    The inflationary scenario is nowadays the most natural and simple way to solve the problems of the standard Friedmann-Lemaître-Robertson-Walker cosmology. Generally, inflation is driven by models of gravity minimally coupled to a scalar field ϕ rolling on a suitable potential V (ϕ). We discuss a particular model presenting two scenarios: the vacuum universe and the matter-filled universe, in order to find exact general isotropic and homogeneous cosmological solutions displaying an inflationary behavior at early times and a power-law expansion at late times.

  1. Classical and quantum contents of solvable game theory on Hilbert space

    International Nuclear Information System (INIS)

    Cheon, Taksu; Tsutsui, Izumi

    2006-01-01

    A simple and general formulation of the quantum game theory is presented, accommodating all possible strategies in the Hilbert space for the first time. The theory is solvable for the two strategy quantum game, which is shown to be equivalent to a family of classical games supplemented by quantum interference. Our formulation gives a clear perspective to understand why and how quantum strategies outmaneuver classical strategies. It also reveals novel aspects of quantum games such as the stone-scissor-paper phase sub-game and the fluctuation-induced moderation

  2. Conditions for the Solvability of the Linear Programming Formulation for Constrained Discounted Markov Decision Processes

    Energy Technology Data Exchange (ETDEWEB)

    Dufour, F., E-mail: dufour@math.u-bordeaux1.fr [Institut de Mathématiques de Bordeaux, INRIA Bordeaux Sud Ouest, Team: CQFD, and IMB (France); Prieto-Rumeau, T., E-mail: tprieto@ccia.uned.es [UNED, Department of Statistics and Operations Research (Spain)

    2016-08-15

    We consider a discrete-time constrained discounted Markov decision process (MDP) with Borel state and action spaces, compact action sets, and lower semi-continuous cost functions. We introduce a set of hypotheses related to a positive weight function which allow us to consider cost functions that might not be bounded below by a constant, and which imply the solvability of the linear programming formulation of the constrained MDP. In particular, we establish the existence of a constrained optimal stationary policy. Our results are illustrated with an application to a fishery management problem.

  3. Global solvability and global hypoellipticity in Gevrey classes for vector fields on the torus

    Science.gov (United States)

    Bergamasco, A. P.; Dattori da Silva, P. L.; Gonzalez, R. B.

    2018-03-01

    Let L = ∂ / ∂ t +∑j=1N (aj + ibj) (t) ∂ / ∂xj be a vector field defined on the torus T N + 1 ≃R N + 1 / 2 πZ N + 1, where aj, bj are real-valued functions and belonging to the Gevrey class Gs (T1), s > 1, for j = 1 , … , N. We present a complete characterization for the s-global solvability and s-global hypoellipticity of L. Our results are linked to Diophantine properties of the coefficients and, also, connectedness of certain sublevel sets.

  4. Exactly solvable nonequilibrium Langevin relaxation of a trapped nanoparticle

    International Nuclear Information System (INIS)

    Salazar, Domingos S P; Lira, Sérgio A

    2016-01-01

    In this work, we study the nonequilibrium statistical properties of the relaxation dynamics of a nanoparticle trapped in a harmonic potential. We report an exact time-dependent analytical solution to the Langevin dynamics that arises from the stochastic differential equation of our system’s energy in the underdamped regime. By utilizing this stochastic thermodynamics approach, we are able to completely describe the heat exchange process between the nanoparticle and the surrounding environment. As an important consequence of our results, we observe the validity of the heat exchange fluctuation theorem in our setup, which holds for systems arbitrarily far from equilibrium conditions. By extending our results for the case of N noninterating nanoparticles, we perform analytical asymptotic limits and direct numerical simulations that corroborate our analytical predictions. (paper)

  5. The Potential Economic Impact of Electricity Restructuring in the State of Oklahoma: Phase II Report; FINAL

    International Nuclear Information System (INIS)

    Hadley, SW

    2001-01-01

    Because of the recent experiences of several states undergoing restructuring (e.g., higher prices, greater volatility, lower reliability), concerns have been raised in states currently considering restructuring as to whether their systems are equally vulnerable. Factors such as local generation costs, transmission constraints, market concentration, and market design can all play a role in the success or failure of the market. These factors along with the mix of generation capacity supplying the state will influence the relative prices paid by consumers. The purpose of this project is to provide a model and process to evaluate the potential price and economic impacts of restructuring the Oklahoma electric industry. The Phase I report concentrated on providing an analysis of the Oklahoma system in the near-term, using only present generation resources and customer demands. This Phase II study analyzed the Oklahoma power market in 2010, incorporating the potential of new generation resources and customer responses. Five key findings of this Phase II were made: (1) Projected expansion in generating capacity exceeds by over 3,000 MW the demands within the state plus the amount that could be exported with the current transmission system. (2) Even with reduced new plant construction, most new plants could lose money (although residential consumers would see lower rates) unless they have sufficient market power to raise their prices without losing significant market share (Figure S-1). (3) If new plants can raise prices to stay profitable, existing low-cost coal and hydro plants will have very high profits. Average prices to customers could be 5% to 25% higher than regulated rates (Figure S-1). If the coal and hydro plants are priced at cost-based rates (through long-term contracts or continued regulation) while all other plants use market-based rates then prices are lower. (4) Customer response to real-time prices can lower the peak capacity requirements by around 9

  6. Pressure in an exactly solvable model of active fluid

    Science.gov (United States)

    Marini Bettolo Marconi, Umberto; Maggi, Claudio; Paoluzzi, Matteo

    2017-07-01

    We consider the pressure in the steady-state regime of three stochastic models characterized by self-propulsion and persistent motion and widely employed to describe the behavior of active particles, namely, the Active Brownian particle (ABP) model, the Gaussian colored noise (GCN) model, and the unified colored noise approximation (UCNA) model. Whereas in the limit of short but finite persistence time, the pressure in the UCNA model can be obtained by different methods which have an analog in equilibrium systems, in the remaining two models only the virial route is, in general, possible. According to this method, notwithstanding each model obeys its own specific microscopic law of evolution, the pressure displays a certain universal behavior. For generic interparticle and confining potentials, we derive a formula which establishes a correspondence between the GCN and the UCNA pressures. In order to provide explicit formulas and examples, we specialize the discussion to the case of an assembly of elastic dumbbells confined to a parabolic well. By employing the UCNA we find that, for this model, the pressure determined by the thermodynamic method coincides with the pressures obtained by the virial and mechanical methods. The three methods when applied to the GCN give a pressure identical to that obtained via the UCNA. Finally, we find that the ABP virial pressure exactly agrees with the UCNA and GCN results.

  7. Potential Malaysia agricultural waste materials for the biosorption of cadmium(II) from aqueous solution

    Energy Technology Data Exchange (ETDEWEB)

    Foo, L.P.Y.; Tee, C.Z.; Raimy, N.R.; Hassell, D.G.; Lee, L.Y. [University of Nottingham Malaysia Campus, Semenyih, Selangor (Malaysia)

    2012-04-15

    Biosorption of cadmium(II) ions (Cd{sup 2+}) onto Ananas comosus (AC) peel, Parkia speciosa (PS) pods and Psidium guajava (PG) peel were investigated in this study. Batch sorption experiments were performed by investigating the effect of initial pH. It was found that Cd{sup 2+} uptake was highly dependent on the initial pH and Cd{sup 2+} removal efficiency was highest for PG peel, followed by AC peel and PS pods. Biosorption experiments were carried out using different initial Cd{sup 2+} concentration and the experimental data obtained was fitted to both Langmuir and Freundlich isotherms. The experimental data was found to best fit the Langmuir isotherm, and adsorption capacities of 18.21 mg/g (AC peel), 25.64 mg/g (PS pods) and 39.68 mg/g (PG peel) were obtained. Comparison with published adsorption capacities for other low-cost biosorbents indicates that PS pods and PG peel have potential as low-cost biosorbent materials for the removal of Cd{sup 2+} from aqueous solution. (orig.)

  8. Spectral transform and solvability of nonlinear evolution equations

    International Nuclear Information System (INIS)

    Degasperis, A.

    1979-01-01

    These lectures deal with an exciting development of the last decade, namely the resolving method based on the spectral transform which can be considered as an extension of the Fourier analysis to nonlinear evolution equations. Since many important physical phenomena are modeled by nonlinear partial wave equations this method is certainly a major breakthrough in mathematical physics. We follow the approach, introduced by Calogero, which generalizes the usual Wronskian relations for solutions of a Sturm-Liouville problem. Its application to the multichannel Schroedinger problem will be the subject of these lectures. We will focus upon dynamical systems described at time t by a multicomponent field depending on one space coordinate only. After recalling the Fourier technique for linear evolution equations we introduce the spectral transform method taking the integral equations of potential scattering as an example. The second part contains all the basic functional relationships between the fields and their spectral transforms as derived from the Wronskian approach. In the third part we discuss a particular class of solutions of nonlinear evolution equations, solitons, which are considered by many physicists as a first step towards an elementary particle theory, because of their particle-like behaviour. The effect of the polarization time-dependence on the motion of the soliton is studied by means of the corresponding spectral transform, leading to new concepts such as the 'boomeron' and the 'trappon'. The rich dynamic structure is illustrated by a brief report on the main results of boomeron-boomeron and boomeron-trappon collisions. In the final section we discuss further results concerning important properties of the solutions of basic nonlinear equations. We introduce the Baecklund transform for the special case of scalar fields and demonstrate how it can be used to generate multisoliton solutions and how the conservation laws are obtained. (HJ)

  9. The Potential Economic Impact of Electricity Restructuring in the State of Oklahoma: Phase II Report; FINAL

    International Nuclear Information System (INIS)

    Hadley, SW

    2001-01-01

    In April 1997, the Oklahoma legislature passed a bill to restructure the state's electric industry, requiring that the generation sector be deregulated and allowing retail competition by July 2002. Details of the market structure were to be established later. Senate Bill No.220, introduced in the 2000 legislature, provided additional details on this market, but the bill did not pass. Subsequent discussions have identified the need for an objective analysis of the impact of restructuring on electricity prices and the state's economy, especially considering the experiences of other states following restructuring of their electric systems. Because of the recent experiences of other states undergoing restructuring (e.g., higher prices, greater volatility, lower reliability), concerns have been raised in states currently considering restructuring as to whether their systems are equally vulnerable. Factors such as local generation costs, transmission constraints, market concentration, and market design can all play a role in the success or failure of the market. Energy and ancillary services markets both play a role in having a well-functioning system. Customer responsiveness to market signals can enhance the flexibility of the market. The purpose of this project is to provide a model and process to evaluate the potential price and economic impacts of restructuring the Oklahoma electric industry. The goal is to provide sufficient objective analysis to the Oklahoma legislature that they may make a more informed decision on the timing and details of any future restructuring. It will also serve to inform other stakeholders on the economic issues surrounding restructuring. The project is being conducted in two phases. The Phase I report (Hadley 2001) concentrated on providing an analysis of the Oklahoma system in the near-term, using only present generation and transmission resources. This Phase II report looks further in the future, incorporating the potential of new

  10. Reaction-driven de novo design, synthesis and testing of potential type II kinase inhibitors.

    Science.gov (United States)

    Schneider, Gisbert; Geppert, Tim; Hartenfeller, Markus; Reisen, Felix; Klenner, Alexander; Reutlinger, Michael; Hähnke, Volker; Hiss, Jan A; Zettl, Heiko; Keppner, Sarah; Spänkuch, Birgit; Schneider, Petra

    2011-03-01

    De novo design of drug-like compounds with a desired pharmacological activity profile has become feasible through innovative computer algorithms. Fragment-based design and simulated chemical reactions allow for the rapid generation of candidate compounds as blueprints for organic synthesis. We used a combination of complementary virtual-screening tools for the analysis of de novo designed compounds that were generated with the aim to inhibit inactive polo-like kinase 1 (Plk1), a target for the development of cancer therapeutics. A homology model of the inactive state of Plk1 was constructed and the nucleotide binding pocket conformations in the DFG-in and DFG-out state were compared. The de novo-designed compounds were analyzed using pharmacophore matching, structure-activity landscape analysis, and automated ligand docking. One compound was synthesized and tested in vitro. The majority of the designed compounds possess a generic architecture present in known kinase inhibitors. Predictions favor kinases as targets of these compounds but also suggest potential off-target effects. Several bioisosteric replacements were suggested, and de novo designed compounds were assessed by automated docking for potential binding preference toward the inactive (type II inhibitors) over the active conformation (type I inhibitors) of the kinase ATP binding site. One selected compound was successfully synthesized as suggested by the software. The de novo-designed compound exhibited inhibitory activity against inactive Plk1 in vitro, but did not show significant inhibition of active Plk1 and 38 other kinases tested. Computer-based de novo design of screening candidates in combination with ligand- and receptor-based virtual screening generates motivated suggestions for focused library design in hit and lead discovery. Attractive, synthetically accessible compounds can be obtained together with predicted on- and off-target profiles and desired activities.

  11. Abnormalities in auditory evoked potentials of 75 patients with Arnold-Chiari malformations types I and II.

    Science.gov (United States)

    Henriques Filho, Paulo Sergio A; Pratesi, Riccardo

    2006-09-01

    To evaluate the frequency and degree of severity of abnormalities in the auditory pathways in patients with Chiari malformations type I and II. This is a series-of-case descriptive study in which the possible presence of auditory pathways abnormalities in 75 patients (48 children and 27 adults) with Chiari malformation types I and II were analyzed by means of auditory evoked potentials evaluation. The analysis was based on the determination of intervals among potentials peak values, absolute latency and amplitude ratio among potentials V and I. Among the 75 patients studied, 27 (36%) disclosed Arnold-Chiari malformations type I and 48 (64%) showed Arnold-Chiari malformations type II. Fifty-three (71%) of these patients showed some degree of auditory evoked potential abnormalities. Tests were normal in the remaining 22 (29%) patients. Auditory evoked potentials testing can be considered a valuable instrument for diagnosis and evaluation of brain stem functional abnormalities in patients with Arnold-Chiari malformations type I and II. The determination of the presence and degree of severity of these abnormalities can be contributory to the prevention of further handicaps in these patients either through physical therapy or by means of precocious corrective surgical intervention.

  12. Quasi-exact solvability and entropies of the one-dimensional regularised Calogero model

    Science.gov (United States)

    Pont, Federico M.; Osenda, Omar; Serra, Pablo

    2018-05-01

    The Calogero model can be regularised through the introduction of a cutoff parameter which removes the divergence in the interaction term. In this work we show that the one-dimensional two-particle regularised Calogero model is quasi-exactly solvable and that for certain values of the Hamiltonian parameters the eigenfunctions can be written in terms of Heun’s confluent polynomials. These eigenfunctions are such that the reduced density matrix of the two-particle density operator can be obtained exactly as well as its entanglement spectrum. We found that the number of non-zero eigenvalues of the reduced density matrix is finite in these cases. The limits for the cutoff distance going to zero (Calogero) and infinity are analysed and all the previously obtained results for the Calogero model are reproduced. Once the exact eigenfunctions are obtained, the exact von Neumann and Rényi entanglement entropies are studied to characterise the physical traits of the model. The quasi-exactly solvable character of the model is assessed studying the numerically calculated Rényi entropy and entanglement spectrum for the whole parameter space.

  13. Application of quasiexactly solvable potential method to the N-body ...

    Indian Academy of Sciences (India)

    2015-11-27

    Proceedings of the International Workshop/Conference on Computational Condensed Matter Physics and Materials Science (IWCCMP-2015). Posted on November 27, 2015. Guest Editors: Anurag Srivastava, C. S. Praveen, H. S. Tewari. © 2015 Indian Academy of Sciences, Bengaluru. Contact | Site index.

  14. Landscape Potential Analysis for Ecotourism Destination in the Resort Ii Salak Mountain, Halimun-Salak National Park

    Science.gov (United States)

    Kusumoarto, A.; Gunawan, A.; Nurazizah, G. R.

    2017-10-01

    The Resort II Salak Mountain has variety of landscape potential for created as ecotourism destination, especially the potential of the waterfall (curug) and sulphur crater (Kawah Ratu). The aim of this study was to identify and analyze the potential resources of the landscape to be created as ecotourism destination, Resort II Salak Mountain. This research was conducted through two phases: 1) identification of the attractions location that have potential resources for ecotourism destination, and 2) analysis of the level of potential resource of the landscape in each location using Analysis of Tourist Attraction Operational Destination (ATAOD). The study showed Resort II Salak Mountain has many ecotourism objects which have been used for ecotourism activities, such as hot spring baths, Curug Cigamea, Curug Ngumpet, Curug Seribu, Curug Pangeran, Curug Muara, Curug Cihurang, Kawah Ratu, camping ground, Curug Kondang and Curug Alami. The location of all waterfalls -curug, spread widely in the core zone for ecotourism. In the other hand, camping ground is located in the business zone, while Kawah Ratu is located in the natural forest, which is included in the buffer zone of Halimun-Salak National Park (HSNP). The result showed that the ecotourism objects with the highest potential value are Kawah Ratu, Curug Seribu, Curug Muara, Curug Kondang and Curug Ngumpet.

  15. MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis.

    Science.gov (United States)

    Lipski, Deborah A; Dewispelaere, Rémi; Foucart, Vincent; Caspers, Laure E; Defrance, Matthieu; Bruyns, Catherine; Willermain, François

    2017-07-18

    II-associated antigen presentation and in T cell activation than non-hematopoietic cells. Our results highlight the potential of cells of hematopoietic origin in local antigen presentation, whatever their Ly6C expression. Our work further provides a first transcriptomic study of MHC class II-expressing retinal cells during EAU and delivers a series of new candidate genes possibly implicated in the pathogenesis of retinal autoimmunity.

  16. Local solvability and solution blow-up of one-dimensional equations of the Yajima-Oikawa-Satsuma type

    Science.gov (United States)

    Panin, A. A.; Shlyapugin, G. I.

    2017-11-01

    We consider one-dimensional equations of the type of the Yajima-Oikawa-Satsuma ion acoustic wave equation and prove the local solvability. Using the test function method, we obtain sufficient conditions for solution blow-up and estimate the blow-up time.

  17. Solvability conditions of the Cauchy problem for two-dimensional systems of linear functional differential equations with monotone operators

    Czech Academy of Sciences Publication Activity Database

    Šremr, Jiří

    2007-01-01

    Roč. 132, č. 3 (2007), s. 263-295 ISSN 0862-7959 R&D Projects: GA ČR GP201/04/P183 Institutional research plan: CEZ:AV0Z10190503 Keywords : system of functional differential equations with monotone operators * initial value problem * unique solvability Subject RIV: BA - General Mathematics

  18. In vitro combinatory effects of the Alternaria mycotoxins alternariol and altertoxin II and potentially involved miRNAs.

    Science.gov (United States)

    Vejdovszky, Katharina; Sack, Matej; Jarolim, Katharina; Aichinger, Georg; Somoza, Mark M; Marko, Doris

    2017-02-05

    Alternariol (AOH) and altertoxin II (ATX II) are mycotoxins formed by Alternaria spp. Since they are expected to co-occur in Alternaria-infested food and feed, we addressed the question of combinatory effects. In addition, potentially involved regulatory microRNAs were surveyed in an exploratory approach. Cytotoxicity measurements in constant ratio combinations of 1:10 or 1:1 (ATX II: AOH) mainly revealed additive effects in HepG2, HT29 and HCEC-1CT cells. Yet, in specific high doses antagonism was found. Microarray analysis of miRNA expression profiles in HepG2 cells indicated different patterns of miRNA regulation by AOH and ATX II, including several miRNA species for which no distinct functions are currently known. Among others, miR-4654, miR-4715_3p and miR-6720_3p were up-regulated by AOH and miR-5583_5p was down-regulated by ATX II. Additionally, miR-1323, involved in hindering DNA repair mechanisms, was decreased by ATX II. Digital droplet PCR (ddPCR) analysis of selected miRNAs indicated regulation of miR-29a by AOH, which might play a role in AOH-induced apoptosis. miR-192 and miR-224 regulation was associated with antagonistic cytotoxic effects of AOH and ATX II combinations. Our study represents the first evaluation on combinatory effects of AOH and ATX II. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  19. Riproximin is a recently discovered type II ribosome inactivating protein with potential for treating cancer.

    Science.gov (United States)

    Adwan, Hassan; Bayer, Helene; Pervaiz, Asim; Sagini, Micah; Berger, Martin R

    2014-11-01

    The development of new anticancer drugs is a salient problem and the traditional use of plants is a potentially rich source of information for detecting new molecules with antineoplastic activity. Riproximin is a recently detected cytotoxic type II ribosome inactivating protein with high selectivity for certain tumor cell lines. Its activity was recognized as the main component in a plant powder used by African healers for treating cancer. By ribulose bisphosphate carboxylase gene sequencing analysis, the powder was identified to be derived from the plant Ximenia americana. The cDNA sequence of riproximin was identified, the protein was modeled to contain one A- and a B-chain, respectively, and a reliable purification procedure from kernels of X. americana was established. Riproximin displays high but differential antiproliferative activity in a panel of human and rodent cancer cell lines, with concentrations inhibiting cell proliferation by 50% (IC50 values) that diverge by a factor of 100. Consistent antineoplastic activity was detected in colorectal and pancreatic cancer liver metastasis models in rats. The cytotoxic mechanism of action was determined to be based on cellular uptake of riproximin followed by its A-chain prompted depurination of the 28S ribosomal RNA and induction of unfolded protein response. Riproximin's specificity depended on its B-chain connected binding to cell surface glycans, the presence of which is crucial for subsequent internalization into cells and cytotoxicity. These N- and O-glycans include bi- and tri-antennary NA structures (NA2/NA3) as well as Tn3 structures (clustered Tn antigen). Riproximin was found to crosslink proteins with N- and O-glycan structure, thus indicating both types of binding sites on its B chain. Due to this crosslinking ability, riproximin is expected to show prominent cytotoxicity towards cells expressing both, NA2/NA3 and clustered Tn structures. Apart from the properties of riproximin, the plant X. americana

  20. Relativistic model-potential oscillator strengths and transition probabilities for 4fsup(n)6s-4fsup(n)6p transitions in Eu(II), Tb(II), and Ho(II) in J1j coupling

    International Nuclear Information System (INIS)

    Migdalek, J.

    1984-01-01

    The lowest 4fsup(n)6s-4fsup(n)6p transitions are studied for the Eu(II) (n=7), Tb(II) (n=9), and Ho(II) (n=11) spectra, where the J 1 J coupling is an acceptable approximation. The relativistic radial integrals, required to evaluate the oscillator strengths and transition probabilities, are calculated with the model-potential method, which includes also core-polarization effects. The similarities observed in oscillator strengths for transitions with given ΔJ but different J values are discussed and explained. The computed oscillator strengths are compared with those obtained with the Coulomb approximation and it is found that the latter are only 11-12% lower. The core polarization influence on oscillator strengths is also investigated and the 19-21% decrease in oscillator strengths due to this effect is predicted. This result may, however, be overestimated because of some deficiencies in our procedure. (author)

  1. E2-quasi-exact solvability for non-Hermitian models

    International Nuclear Information System (INIS)

    Fring, Andreas

    2015-01-01

    We propose the notion of E 2 -quasi-exact solvability and apply this idea to find explicit solutions to the eigenvalue problem for a non-Hermitian Hamiltonian system depending on two parameters. The model considered reduces to the complex Mathieu Hamiltonian in a double scaling limit, which enables us to compute the exceptional points in the energy spectrum of the latter as a limiting process of the zeros for some algebraic equations. The coefficient functions in the quasi-exact eigenfunctions are univariate polynomials in the energy obeying a three-term recurrence relation. The latter property guarantees the existence of a linear functional such that the polynomials become orthogonal. The polynomials are shown to factorize for all levels above the quantization condition leading to vanishing norms rendering them to be weakly orthogonal. In two concrete examples we compute the explicit expressions for the Stieltjes measure. (paper)

  2. E2-quasi-exact solvability for non-Hermitian models

    Science.gov (United States)

    Fring, Andreas

    2015-04-01

    We propose the notion of E2-quasi-exact solvability and apply this idea to find explicit solutions to the eigenvalue problem for a non-Hermitian Hamiltonian system depending on two parameters. The model considered reduces to the complex Mathieu Hamiltonian in a double scaling limit, which enables us to compute the exceptional points in the energy spectrum of the latter as a limiting process of the zeros for some algebraic equations. The coefficient functions in the quasi-exact eigenfunctions are univariate polynomials in the energy obeying a three-term recurrence relation. The latter property guarantees the existence of a linear functional such that the polynomials become orthogonal. The polynomials are shown to factorize for all levels above the quantization condition leading to vanishing norms rendering them to be weakly orthogonal. In two concrete examples we compute the explicit expressions for the Stieltjes measure.

  3. Fundamental solutions and local solvability for nonsmooth Hörmander’s operators

    CERN Document Server

    Bramanti, Marco; Manfredini, Maria

    2017-01-01

    The authors consider operators of the form L=\\sum_{i=1}^{n}X_{i}^{2}+X_{0} in a bounded domain of \\mathbb{R}^{p} where X_{0},X_{1},\\ldots,X_{n} are nonsmooth Hörmander's vector fields of step r such that the highest order commutators are only Hölder continuous. Applying Levi's parametrix method the authors construct a local fundamental solution \\gamma for L and provide growth estimates for \\gamma and its first derivatives with respect to the vector fields. Requiring the existence of one more derivative of the coefficients the authors prove that \\gamma also possesses second derivatives, and they deduce the local solvability of L, constructing, by means of \\gamma, a solution to Lu=f with Hölder continuous f. The authors also prove C_{X,loc}^{2,\\alpha} estimates on this solution.

  4. Integrability and solvability of the simplified two-qubit Rabi model

    International Nuclear Information System (INIS)

    Peng Jie; Ren Zhongzhou; Guo Guangjie; Ju Guoxing

    2012-01-01

    The simplified two-qubit Rabi model is proposed and its analytical solution is presented. There are no level crossings in the spectral graph of the model, which indicates that it is not integrable. The criterion of integrability for the Rabi model proposed by Braak (2011 Phys. Rev. Lett. 107 100401) is also used for the simplified two-qubit Rabi model and the same conclusion, consistent with what the spectral graph shows, can be drawn, which indicates that the criterion remains valid when applied to the two-qubit case. The simplified two-qubit Rabi model is another example of a non-integrable but exactly solvable system except for the generalized Rabi model. (paper)

  5. Flow equations for Hamiltonians: contrasting different approaches by using a numerically solvable model

    International Nuclear Information System (INIS)

    Stauber, T; Mielke, A

    2003-01-01

    To contrast different generators for flow equations for Hamiltonians and to discuss the dependence of physical quantities on unitarily equivalent, but effectively different, initial Hamiltonians, a numerically solvable model is considered which is structurally similar to impurity models. By this we discuss the question of optimization for the first time. A general truncation scheme is established that produces good results for the Hamiltonian flow as well as for the operator flow. Nevertheless, it is also pointed out that a systematic and feasible scheme for the operator flow on the operator level is missing. For this, an explicit analysis of the operator flow is given for the first time. We observe that truncation of the series of the observable flow after the linear or bilinear terms does not yield satisfactory results for the entire parameter regime as - especially close to resonances - even high orders of the exact series expansion carry considerable weight

  6. An exactly solvable model for the integrability-chaos transition in rough quantum billiards.

    Science.gov (United States)

    Olshanii, Maxim; Jacobs, Kurt; Rigol, Marcos; Dunjko, Vanja; Kennard, Harry; Yurovsky, Vladimir A

    2012-01-24

    A central question of dynamics, largely open in the quantum case, is to what extent it erases a system's memory of its initial properties. Here we present a simple statistically solvable quantum model describing this memory loss across an integrability-chaos transition under a perturbation obeying no selection rules. From the perspective of quantum localization-delocalization on the lattice of quantum numbers, we are dealing with a situation where every lattice site is coupled to every other site with the same strength, on average. The model also rigorously justifies a similar set of relationships, recently proposed in the context of two short-range-interacting ultracold atoms in a harmonic waveguide. Application of our model to an ensemble of uncorrelated impurities on a rectangular lattice gives good agreement with ab initio numerics.

  7. Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons

    Directory of Open Access Journals (Sweden)

    Smith Paula L

    2011-09-01

    Full Text Available Abstract Background Voltage-gated sodium channels play key roles in acute and chronic pain processing. The molecular, biophysical, and pharmacological properties of sodium channel currents have been extensively studied for peripheral nociceptors while the properties of sodium channel currents in dorsal horn spinal cord neurons remain incompletely understood. Thus far, investigations into the roles of sodium channel function in nociceptive signaling have primarily focused on recombinant channels or peripheral nociceptors. Here, we utilize recordings from lamina I/II neurons withdrawn from the surface of spinal cord slices to systematically determine the functional properties of sodium channels expressed within the superficial dorsal horn. Results Sodium channel currents within lamina I/II neurons exhibited relatively hyperpolarized voltage-dependent properties and fast kinetics of both inactivation and recovery from inactivation, enabling small changes in neuronal membrane potentials to have large effects on intrinsic excitability. By combining biophysical and pharmacological channel properties with quantitative real-time PCR results, we demonstrate that functional sodium channel currents within lamina I/II neurons are predominantly composed of the NaV1.2 and NaV1.3 isoforms. Conclusions Overall, lamina I/II neurons express a unique combination of functional sodium channels that are highly divergent from the sodium channel isoforms found within peripheral nociceptors, creating potentially complementary or distinct ion channel targets for future pain therapeutics.

  8. Investigation on Pleurotus ferulae potential for the sorption of Pb(II ...

    African Journals Online (AJOL)

    Pleurotus ferulae obtained from rotten tree was collected, washed, dried, ground and sieved to appropriate particle size. Infra-red spectrometry was used to determine functional groups on the biomass while biosorption of Pb(II) from aqueous solution was studied using the biomass in a batch system. The effect of pH (1-7.5), ...

  9. External Cooling of the BWR Mark I and II Drywell Head as a Potential Accident Mitigation Measure – Scoping Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Robb, Kevin R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-08-01

    This report documents a scoping assessment of a potential accident mitigation action applicable to the US fleet of boiling water reactors with Mark I and II containments. The mitigation action is to externally flood the primary containment vessel drywell head using portable pumps or other means. A scoping assessment of the potential benefits of this mitigation action was conducted focusing on the ability to (1) passively remove heat from containment, (2) prevent or delay leakage through the drywell head seal (due to high temperatures and/or pressure), and (3) scrub radionuclide releases if the drywell head seal leaks.

  10. Synthesis and Biological Evaluation of Ru(II) and Pt(II) Complexes Bearing Carboxyl Groups as Potential Anticancer Targeted Drugs.

    Science.gov (United States)

    Martínez, Ma Ángeles; Carranza, M Pilar; Massaguer, Anna; Santos, Lucia; Organero, Juan A; Aliende, Cristina; de Llorens, Rafael; Ng-Choi, Iteng; Feliu, Lidia; Planas, Marta; Rodríguez, Ana M; Manzano, Blanca R; Espino, Gustavo; Jalón, Félix A

    2017-11-20

    The synthesis and characterization of Pt(II) (1 and 2) and Ru(II) arene (3 and 4) or polypyridine (5 and 6) complexes is described. With the aim of having a functional group to form bioconjugates, one uncoordinated carboxyl group has been introduced in all complexes. Some of the complexes were selected for their potential in photodynamic therapy (PDT). The molecular structures of complexes 2 and 5, as well as that of the sodium salt of the 4'-(4-carboxyphenyl)-2,2':6',2″-terpyridine ligand (cptpy), were determined by X-ray diffraction. Different techniques were used to evaluate the binding capacity to model DNA molecules, and MTT cytotoxicity assays were performed against four cell lines. Compounds 3, 4, and 5 showed little tendency to bind to DNA and exhibited poor biological activity. Compound 2 behaves as bonded to DNA probably through a covalent interaction, although its cytotoxicity was very low. Compound 1 and possibly 6, both of which contain a cptpy ligand, were able to intercalate with DNA, but toxicity was not observed for 6. However, compound 1 was active in all cell lines tested. Clonogenic assays and apoptosis induction studies were also performed on the PC-3 line for 1. The photodynamic behavior for complexes 1, 5, and 6 indicated that their nuclease activity was enhanced after irradiation at λ = 447 nm. The cell viability was significantly reduced only in the case of 5. The different behavior in the absence or presence of light makes complex 5 a potential prodrug of interest in PDT. Molecular docking studies followed by molecular dynamics simulations for 1 and the counterpart without the carboxyl group confirmed the experimental data that pointed to an intercalation mechanism. The cytotoxicity of 1 and the potential of 5 in PDT make them good candidates for subsequent conjugation, through the carboxyl group, to "selected peptides" which could facilitate the selective vectorization of the complex toward receptors that are overexpressed in

  11. Adsorption of Cd(II) and Pb(II) by in situ oxidized Fe3O4membrane grafted on 316L porous stainless steel filter tube and its potential application for drinking water treatment.

    Science.gov (United States)

    Zhu, Mengfei; Zhu, Li; Wang, Jianlong; Yue, Tianli; Li, Ronghua; Li, Zhonghong

    2017-07-01

    Removing heavy metal ions from aqueous solutions is one of the most challenging separations. In situ oxidized Fe 3 O 4 membranes using 316L porous stainless steel filter tube have shown great potential for removing anion Cr(VI). Here we report the performances of the in situ oxidized Fe 3 O 4 membranes for removing two toxic cations Cd(II) and Pb(II) commonly existing in water and their potential applications for drinking water purification. The membranes exhibited high removal efficiency: 97% at pH 9.0 for Cd(II) of 1.0 mg/L initial concentration and 100% at pH 5.0-6.0 for Pb(II) of 5.0 mg/L initial concentration. The maximum adsorption capabilities were estimated at 0.800 mg/g and 2.251 mg/g respectively for Cd(II) and Pb(II) at 318 K by the Langmuir model. Results of batch tests revealed the existence of electrostatic attraction and chemisorption. XRD and FT-IR analyses indicated that the chemisorption might be the insertion of Cd(II) and Pb(II) into the Fe 3 O 4 crystal faces of 311 and 511 to form mononuclear or binuclear coordination with O atoms of Fe-O 6 groups. Competitive adsorption of Cd(II) and Pb(II) in binary solutions revealed a preferential adsorption for Pb(II). Na 2 EDTA solution was used to regenerate the membranes, and the maximum desorption ratio was 90.29% and 99.75% respectively for Cd(II) and Pb(II). The membranes were able to efficiently lower Cd(II) and Pb(II) concentrations to meet the drinking water standards recommended by the World Health Organization and are promising for engineering applications aimed at drinking water purification. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. PT-symmetry and Non-Central Potentials

    Directory of Open Access Journals (Sweden)

    G. Lévai

    2007-01-01

    Full Text Available We present a general procedure by which solvable non-central potentials can be obtained in 2 and 3 dimensions by the separation of the angular and radial variables. The method is applied to generate solvable non-central PT-symmetric potentials in polar coordinates. General considerations are presented concerning the PT transformation properties of the eigenfunctions, their pseudo-norm and the nature of the energy eigenvalues. It is shown that within the present framework the spontaneous breakdown of PT symmetry can be implemented only in two dimensions. 

  13. Potential safety enhancements to nuclear plant control: proof testing at EBR-II

    International Nuclear Information System (INIS)

    Lindsay, R.W.; Chisholm, G.H.

    1984-01-01

    Future changes in nuclear plant control and protective systems will reflect an evolutionary improvement through increased use of computers coupled with a better integration of man and machine. Before improvements can be accepted into the licensed commercial plant environment, significant testing must be accomplished to answer safety questions and to prove the worth of new ideas. The Experimental Breeder Reactor-II (EBR-II) is being used as a test-bed for both in-house development and testing for others in a DOE sponsored Man-Machine Integration program. The ultimate result of the development and testing would be a control system for which safety credit could be taken in the licensing process

  14. Crystalline Nanosuspensions as Potential Toxicology and Clinical Oral Formulations for BCS II/IV Compounds

    OpenAIRE

    Kesisoglou, Filippos; Mitra, Amitava

    2012-01-01

    Nanosuspensions, formulations based on the reduction of the active pharmaceutical ingredient (API) particle size in the sub-micron range and most typically around 100–200 nm, represent a valuable option for formulators to facilitate oral absorption of Biopharmaceutics Classification System class II and IV compounds. Their ability to increase the API dissolution rate and subsequent absorption and thus oral bioavailability has been demonstrated in preclinical and clinical settings. This review ...

  15. Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients

    Directory of Open Access Journals (Sweden)

    Kazuyoshi Shiga

    2016-01-01

    Full Text Available Aims. To evaluate the prognostic significance of serum interleukin-6 (IL-6 in colorectal cancer (CRC. Patients and Methods. Preoperative serum IL-6 was measured in 233 CRC patients and 13 healthy controls. Relationships between IL-6 and various clinicopathological factors were evaluated, and the overall survival (OS and disease-free survival (DFS rates according to IL-6 status were calculated for all patients and according to disease stage. Results. The mean IL-6 level was 6.6 pg/mL in CRC patients and 2.6 pg/mL in healthy controls. Using a cutoff of 6.3 pg/mL, obtained using receiver operating characteristic curve analysis, 57 patients had a high IL-6 level. The mean value was higher for stage II disease than for stage III disease. IL-6 status correlated with C-reactive protein (CRP and carcinoembryonic antigen levels, obstruction, and pT4 disease. The OS differed according to the IL-6 status for all patients, whereas the DFS differed for all patients and for those with stage II disease. The Cox proportional hazards model showed that pT4 disease was an independent risk factor for recurrence in all CRC patients; IL-6, CRP, and pT4 were significant risk factors in stage II patients. Conclusions. The preoperative IL-6 level influences the risk of CRC recurrence.

  16. Novel copper (II) alginate hydrogels and their potential for use as anti-bacterial wound dressings

    International Nuclear Information System (INIS)

    Klinkajon, Wimonwan; Supaphol, Pitt

    2014-01-01

    The incorporation of a metal ion, with antimicrobial activity, into an alginate dressing is an attractive approach to minimize infection in a wound. In this work, copper (II) cross-linked alginate hydrogels were successfully prepared using a two-step cross-linking procedure. In the first step, solid alginate films were prepared using a solvent-casting method from soft gels of alginate solutions that had been lightly cross-linked using a copper (II) (Cu 2+ ) sulfate solution. In the second step, the films were further cross-linked in a corresponding Cu 2+ sulfate solution using a dipping method to further improve their dimensional stability. Alginate solution (at 2%w/v) and Cu 2+ sulfate solution (at 2%w/v) in acetate buffer at a low pH provided soft films with excellent swelling behavior. An increase in either Cu 2+ ion concentration or cross-linking time led to hydrogels with more densely-cross-linked networks that limited water absorption. The hydrogels clearly showed antibacterial activity against Escherichia coli, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis and Streptococcus pyogenes, which was proportional to the Cu 2+ ion concentration. Blood coagulation studies showed that the tested copper (II) cross-linked alginate hydrogels had a tendency to coagulate fibrin, and possibly had an effect on pro-thrombotic coagulation and platelet activation. Conclusively, the prepared films are likely candidates as antibacterial wound dressings. (paper)

  17. Harmonic analysis and global solvability of a differential operator invariant on motion groups and semi-simple Lie groups

    International Nuclear Information System (INIS)

    El-Hussein, K.

    1991-08-01

    Let V be a real finite dimensional vector space and let K be a connected compact Lie group, which acts on V by means of a continuous linear representation ρ. Let G=V x p K be the motion group which is the semi-direct product of V by K and let P be an invariant differential operator on G. In this paper we give a necessary and sufficient condition for the global solvability of P on G. Now let G be a connected semi-simple Lie group with finite centre and let P be an invariant differential operator on G. We give also a necessary and sufficient condition for the global solvability of P on G. (author). 8 refs

  18. Exactly-solvable generalization of the Jaynes-Cummings model and its application to atom-molecule systems

    Energy Technology Data Exchange (ETDEWEB)

    Pittel, S. [Bartol Research Institute, University of Delaware, Newark, Delaware 19716 (United States); Dukelsky, J. [Instituto de Estructura de la Materia, Consejo Superior de Investigaciones Cientificas, Serrano 123, 28006 Madrid (Spain); Dussel, G.G. [Departamento de Fisica Juan Jose Giambiagi, Universidad de Buenos Aires, 1428 Buenos Aires (Argentina)

    2004-12-01

    We present a family of exactly-solvable models involving the interaction of an ensemble of coupled SU(2) or SU(1,1) systems with a single bosonic field. They arise from the trigonometric Richardson-Gaudin models by replacing one SU(2) or SU(1,1) degree of freedom by an ideal boson. A first application to a system of bosonic atoms and a molecule dimer is reported. (Author) 14 refs., 3 figs.

  19. Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation.

    Science.gov (United States)

    Michael, G; Dempster, J; Kane, K A; Coker, S J

    2007-12-01

    Torsade de pointes (TdP) can be induced by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether IKs blockade or enhancement of INa could potentiate TdP induced by IKr blockade and to investigate whether short-term variability (STV) or triangulation of action potentials preceded TdP. Experiments were performed in open-chest, pentobarbital-anaesthetized, alpha 1-adrenoceptor-stimulated, male New Zealand White rabbits, which received three consecutive i.v. infusions of either the IKr blocker E-4031 (1, 3 and 10 nmol kg(-1) min(-1)), the IKs blocker HMR1556 (25, 75 and 250 nmol kg(-1) min(-1)) or E-4031 and HMR1556 combined. In a second study rabbits received either the same doses of E-4031, the INa enhancer, ATX-II (0.4, 1.2 and 4.0 nmol kg(-1)) or both of these drugs. ECGs and epicardial monophasic action potentials were recorded. HMR1556 alone did not cause TdP but increased E-4031-induced TdP from 25 to 80%. ATX-II alone caused TdP in 38% of rabbits, as did E-4031; 75% of rabbits receiving both drugs had TdP. QT intervals were prolonged by all drugs but the extent of QT prolongation was not related to the occurrence of TdP. No changes in STV were detected and triangulation was only increased after TdP occurred. Giving modulators of ion channels in combination substantially increased TdP but, in this model, neither STV nor triangulation of action potentials could predict TdP.

  20. Countermeasures for electrolytic corrosion - Part II: Implementation of a rapid potential-controlled rectifier

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Tae-Hyun; Kim, Dae-Kyeong; Lee, Hyun-Goo; Ha, Yoon-Cheol; Bae, Jeong-Hyo [Underground Systems Group, Korea Electrotechnology Research Institute, 28-1 Sungju-dong, Changwon, 641-120 (Korea)

    2004-07-01

    In electrolytic interference circumstances such as underground pipelines in the vicinity of DC electrified railroads, drainage method or impressed current cathodic protection method has been widely used as a countermeasure for the electrolytic corrosion. In the former method, forced or polarized drainage is commonly adopted and in the latter, the phase-controlled rectifier with thyristor is in common use. Both methods, however, does not show as the optimal measure for the integrity of the pipeline, since the pipe-to-soil potential fluctuates highly positive to the cathodic protection criterion. In particular, as the potential of the pipeline near the railroad varies rapidly, a new rapidly responding countermeasure is necessary. In this paper, we introduce a new rapid potential controlled rectifier and report the result in field tests. Comparison with the existing forced drainage method is also made. The pipe-to-soil potential data show the effectiveness of the rapid potential-controlled rectifier. (authors)

  1. Rhodium (II) cycle alkanecarboxylate: synthesis, spectroscopic and thermo analytic studies and evaluation of the antitumor potential

    International Nuclear Information System (INIS)

    Souza, Aparecido Ribeiro de

    1995-01-01

    Four new rhodium(II) carboxylates (cyclopropane, cyclobutane, cyclopentane, and cyclohexanecarboxylate), and other already known rhodium (II) carboxylates (acetate, propionate, butyrate, metoxyacetate, dichloroacetate, and trifluoroacetate), have been prepared for study in this work. The compounds were characterized by elementary and thermogravimetric analysis, magnetic susceptibility, and electronic, Raman, and infrared spectroscopy. The reaction of Rh CL 3 .aq with the sodium carboxylates was studied aiming to improve the understanding of the redox process involved. Spectroscopy studies (Raman and electronic) were made to examine the transition involved in the Rh-Rh and Rh-O bonds. The results have shown a direct relation between the force of the carboxylic acid and the Rh-O force, but show a inverse relation with the Rh-Rh bond force. Thermal analysis studies were undertaken and the obtained date show a resemblance of the TG/DTG curves with that found in literature. In the other hand, the DSC curves show a different results: in open crucible, the peaks associated with the cage breakdown are exothermic and, in closed crucible this peaks are endothermic. The thermodecomposition products were analyzed. The evolved gases were identified by GC?MS and 1 H and 13 C NMR spectra. The residues were analyzed by X-ray diffraction. Antitumor activity of rhodium cyclopropanecarboxylate was evaluated in vitro (cell cultures K562 and Ehrlich) and in vivo (Balb-c mice with ascite Ehrlich tumor), indicating an increased life span (87.5%) of the treated animals. (author)

  2. Biochemical properties of recombinant leucine aminopeptidase II from Bacillus stearothermophilus and potential applications in the hydrolysis of Chinese anchovy (Engraulis japonicus) proteins.

    Science.gov (United States)

    Wang, Fanghua; Ning, Zhengxiang; Lan, Dongming; Liu, Yuanyuan; Yang, Bo; Wang, Yonghua

    2012-01-11

    The effects of various factors on the activity and conformation of recombinant leucine aminopeptidase II (rLAP II) from Bacillus stearothermophilus and its potential utilization in the hydrolysis of anchovy proteins were investigated. The optimal temperature and pH of rLAP II were 55 °C and 8.0 in phosphate buffer, and its activity was strongly stimulated by Co(2+). Conformational studies indicated that maintaining the α-helical structure had a critical effect on rLAP II activity. rLAP II was used to hydrolyze anchovy proteins, and it exhibited high specificity for peptides with molecular weight between 6000 and 1000 Da and positive coordination with endogenous enzymes and commercial Flavourzyme. Its use will enhance protein hydrolysis in species of aquatic animals. rLAP II could potentially be used to remove bitterness in the protein hydrolysis industry.

  3. An assessment of BWR (boiling water reactor) Mark-II containment challenges, failure modes, and potential improvements in performance

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, D.L.; Jones, K.R.; Dallman, R.J. (EG and G Idaho, Inc., Idaho Falls, ID (USA)); Wagner, K.C. (Science Applications International Corp., Albuquerque, NM (USA))

    1990-07-01

    This report assesses challenges to BWR Mark II containment integrity that could potentially arise from severe accidents. Also assessed are some potential improvements that could prevent core damage or containment failure, or could mitigate the consequences of such failure by reducing the release of fission products to the environment. These challenges and improvements are analyzed via a limited quantitative risk/benefit analysis of a generic BWR/4 reactor with Mark II containment. Point estimate frequencies of the dominant core damage sequences are obtained and simple containment event trees are constructed to evaluate the response of the containment to these severe accident sequences. The resulting containment release modes are then binned into source term release categories, which provide inputs to the consequence analysis. The output of the consequences analysis is used to construct an overall base case risk profile. Potential improvements and sensitivities are evaluated by modifying the event tree spilt fractions, thus generating a revised risk profile. Several important sensitivity cases are examined to evaluate the impact of phenomenological uncertainties on the final results. 75 refs., 25 figs., 65 tabs.

  4. Preformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide.

    Science.gov (United States)

    Lan, E L; Ugwu, S O; Blanchard, J; Fang, X; Hruby, V J; Sharma, S

    1994-08-01

    Melanotan-II (1) is a cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (alpha-MSH) which tans the skin and is currently being evaluated for the prevention of sunlight-induced skin cancers. The dissociation constants of 1 were determined using potentiometric titration and ultraviolet spectrophotometry. The pKa1 (histidine) and pKa2 (arginine) were estimated to be 6.54 and 11.72, respectively. The apparent partition coefficient (PC) was measured at three pH values using both n-octanol and isooctane as the nonpolar phase. The PC(octanol) and delta log PC at pH 7.35 were 2.82 and 1.05, respectively. These data, together with the observance of a bioavailability of 4.6% in the rat, indicate that 1 may be a suitable candidate for oral delivery. The data presented here are useful in developing an appropriate dosage form for 1.

  5. ALMA REVEALS POTENTIAL LOCALIZED DUST ENRICHMENT FROM MASSIVE STAR CLUSTERS IN II Zw 40

    Energy Technology Data Exchange (ETDEWEB)

    Consiglio, S. Michelle; Turner, Jean L. [Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, CA 90095 (United States); Beck, Sara [Department of Physics and Astronomy, University of Tel Aviv, Ramat Aviv (Israel); Meier, David S., E-mail: smconsiglio@ucla.edu [Department of Physics, New Mexico Institute of Mining and Technology, Socorro, NM 87801 (United States)

    2016-12-10

    We present subarcsecond images of submillimeter CO and continuum emission from a local galaxy forming massive star clusters: the blue compact dwarf galaxy II Zw 40. At ∼0.″4 resolution (20 pc), the CO(3-2), CO(1-0), 3 mm, and 870 μ m continuum maps illustrate star formation on the scales of individual molecular clouds. Dust contributes about one-third of the 870 μ m continuum emission, with free–free accounting for the rest. On these scales, there is not a good correspondence between gas, dust, and free–free emission. Dust continuum is enhanced toward the star-forming region as compared to the CO emission. We suggest that an unexpectedly low and spatially variable gas-to-dust ratio is the result of rapid and localized dust enrichment of clouds by the massive clusters of the starburst.

  6. Numerical Analysis of Blood Damage Potential of the HeartMate II and HeartWare HVAD Rotary Blood Pumps.

    Science.gov (United States)

    Thamsen, Bente; Blümel, Bastian; Schaller, Jens; Paschereit, Christian O; Affeld, Klaus; Goubergrits, Leonid; Kertzscher, Ulrich

    2015-08-01

    Implantable left ventricular assist devices (LVADs) became the therapy of choice in treating end-stage heart failure. Although survival improved substantially and is similar in currently clinically implanted LVADs HeartMate II (HM II) and HeartWare HVAD, complications related to blood trauma are frequently observed. The aim of this study was to compare these two pumps regarding their potential blood trauma employing computational fluid dynamics. High-resolution structured grids were generated for the pumps. Newtonian flow was calculated, solving Reynolds-averaged Navier-Stokes equations with a sliding mesh approach and a k-ω shear stress transport turbulence model for the operating point of 4.5 L/min and 80 mm Hg. The pumps were compared in terms of volumes subjected to certain viscous shear stress thresholds, below which no trauma was assumed (von Willebrand factor cleavage: 9 Pa, platelet activation: 50 Pa, and hemolysis: 150 Pa), and associated residence times. Additionally, a hemolysis index was calculated based on a Eulerian transport approach. Twenty-two percent of larger volumes above 9 Pa were observed in the HVAD; above 50 Pa and 150 Pa the differences between the two pumps were marginal. Residence times were higher in the HVAD for all thresholds. The hemolysis index was almost equal for the HM II and HVAD. Besides the gap regions in both pumps, the inlet regions of the rotor and diffuser blades have a high hemolysis production in the HM II, whereas in the HVAD, the volute tongue is an additional site for hemolysis production. Thus, in this study, the comparison of the HM II and the HVAD using numerical methods indicated an overall similar tendency to blood trauma in both pumps. However, influences of turbulent shear stresses were not considered and effects of the pivot bearing in the HM II were not taken into account. Further in vitro investigations are required. Copyright © 2015 International Center for Artificial Organs and Transplantation and

  7. A dynamical systems approach to the tilted Bianchi models of solvable type

    Science.gov (United States)

    Coley, Alan; Hervik, Sigbjørn

    2005-02-01

    We use a dynamical systems approach to analyse the tilting spatially homogeneous Bianchi models of solvable type (e.g., types VIh and VIIh) with a perfect fluid and a linear barotropic γ-law equation of state. In particular, we study the late-time behaviour of tilted Bianchi models, with an emphasis on the existence of equilibrium points and their stability properties. We briefly discuss the tilting Bianchi type V models and the late-time asymptotic behaviour of irrotational Bianchi type VII0 models. We prove the important result that for non-inflationary Bianchi type VIIh models vacuum plane-wave solutions are the only future attracting equilibrium points in the Bianchi type VIIh invariant set. We then investigate the dynamics close to the plane-wave solutions in more detail, and discover some new features that arise in the dynamical behaviour of Bianchi cosmologies with the inclusion of tilt. We point out that in a tiny open set of parameter space in the type IV model (the loophole) there exist closed curves which act as attracting limit cycles. More interestingly, in the Bianchi type VIIh models there is a bifurcation in which a set of equilibrium points turns into closed orbits. There is a region in which both sets of closed curves coexist, and it appears that for the type VIIh models in this region the solution curves approach a compact surface which is topologically a torus.

  8. A solvable model of Vlasov-kinetic plasma turbulence in Fourier-Hermite phase space

    Science.gov (United States)

    Adkins, T.; Schekochihin, A. A.

    2018-02-01

    A class of simple kinetic systems is considered, described by the one-dimensional Vlasov-Landau equation with Poisson or Boltzmann electrostatic response and an energy source. Assuming a stochastic electric field, a solvable model is constructed for the phase-space turbulence of the particle distribution. The model is a kinetic analogue of the Kraichnan-Batchelor model of chaotic advection. The solution of the model is found in Fourier-Hermite space and shows that the free-energy flux from low to high Hermite moments is suppressed, with phase mixing cancelled on average by anti-phase-mixing (stochastic plasma echo). This implies that Landau damping is an ineffective route to dissipation (i.e. to thermalisation of electric energy via velocity space). The full Fourier-Hermite spectrum is derived. Its asymptotics are -3/2$ at low wavenumbers and high Hermite moments ( ) and -1/2k-2$ at low Hermite moments and high wavenumbers ( ). These conclusions hold at wavenumbers below a certain cutoff (analogue of Kolmogorov scale), which increases with the amplitude of the stochastic electric field and scales as inverse square of the collision rate. The energy distribution and flows in phase space are a simple and, therefore, useful example of competition between phase mixing and nonlinear dynamics in kinetic turbulence, reminiscent of more realistic but more complicated multi-dimensional systems that have not so far been amenable to complete analytical solution.

  9. Filtering a statistically exactly solvable test model for turbulent tracers from partial observations

    International Nuclear Information System (INIS)

    Gershgorin, B.; Majda, A.J.

    2011-01-01

    A statistically exactly solvable model for passive tracers is introduced as a test model for the authors' Nonlinear Extended Kalman Filter (NEKF) as well as other filtering algorithms. The model involves a Gaussian velocity field and a passive tracer governed by the advection-diffusion equation with an imposed mean gradient. The model has direct relevance to engineering problems such as the spread of pollutants in the air or contaminants in the water as well as climate change problems concerning the transport of greenhouse gases such as carbon dioxide with strongly intermittent probability distributions consistent with the actual observations of the atmosphere. One of the attractive properties of the model is the existence of the exact statistical solution. In particular, this unique feature of the model provides an opportunity to design and test fast and efficient algorithms for real-time data assimilation based on rigorous mathematical theory for a turbulence model problem with many active spatiotemporal scales. Here, we extensively study the performance of the NEKF which uses the exact first and second order nonlinear statistics without any approximations due to linearization. The role of partial and sparse observations, the frequency of observations and the observation noise strength in recovering the true signal, its spectrum, and fat tail probability distribution are the central issues discussed here. The results of our study provide useful guidelines for filtering realistic turbulent systems with passive tracers through partial observations.

  10. Hamiltonian formulation of systems with balanced loss-gain and exactly solvable models

    Science.gov (United States)

    Ghosh, Pijush K.; Sinha, Debdeep

    2018-01-01

    A Hamiltonian formulation of generic many-body systems with balanced loss and gain is presented. It is shown that a Hamiltonian formulation is possible only if the balancing of loss and gain terms occurs in a pairwise fashion. It is also shown that with the choice of a suitable co-ordinate, the Hamiltonian can always be reformulated in the background of a pseudo-Euclidean metric. If the equations of motion of some of the well-known many-body systems like Calogero models are generalized to include balanced loss and gain, it appears that the same may not be amenable to a Hamiltonian formulation. A few exactly solvable systems with balanced loss and gain, along with a set of integrals of motion are constructed. The examples include a coupled chain of nonlinear oscillators and a many-particle Calogero-type model with four-body inverse square plus two-body pair-wise harmonic interactions. For the case of nonlinear oscillators, stable solution exists even if the loss and gain parameter has unbounded upper range. Further, the range of the parameter for which the stable solutions are obtained is independent of the total number of the oscillators. The set of coupled nonlinear equations are solved exactly for the case when the values of all the constants of motions except the Hamiltonian are equal to zero. Exact, analytical classical solutions are presented for all the examples considered.

  11. Exactly solvable models of two-dimensional dilaton cosmology with quantum backreaction

    International Nuclear Information System (INIS)

    Zaslavskii, O B

    2003-01-01

    We consider a general approach to exactly solvable 2D dilaton cosmology with one-loop backreaction from conformal fields taken into account. It includes as particular cases previous models discussed in the literature. We list different types of solutions and investigate their properties for simple models, typical for string theory. We find a rather rich class of everywhere-regular solutions, which exist practically in every type of analysed solution. They exhibit different kinds of asymptotic behaviour in the past and future, including inflation, superinflation, deflation, power expansion or contraction. In particular, for some models the dS spacetime with a time-dependent dilaton field is the exact solution of the field equations. For some kinds of solution the weak-energy condition is violated independently of a specific model. We also find the solutions with a singularity which is situated in an infinite past (or future), so at any finite moment of a comoving time the universe is singularity-free. It is pointed out that for some models the spacetime may be everywhere regular even in spite of infinitely large quantum backreaction in an infinite past

  12. Biological Potential of Halfsandwich Ruthenium(II) and Iridium (III) Complexes.

    Science.gov (United States)

    Ludwig, Gerd; Mojić, Marija; Bulatović, Mirna; Mijatović, Sanja; Maksimović-Ivanić, Danijela; Steinborn, Dirk; Kaluđerović, Goran N

    2016-01-01

    In vitro studies with the ruthenium(II) and analogous iridium(III) complexes [Ru(η6- p-cymene)Cl2{Ph2PCH2CH2CH2S(O)xPh-κP}], [Ru(η6-p-cymene)Cl{Ph2PCH2CH2CH2S(O)xPh- κP,κS}][PF6] (1-4), [Ir(η5-C5Me5)Cl2{Ph2PCH2CH2CH2S(O)xPh-κP}] and [Ir(η5-C5Me5)Cl{Ph2 PCH2CH2CH2S(O)xPh-κP,κS}][PF6] (5-8; x = 0, 1) revealed the high selectivity toward the 8505C, A253, MCF-7, SW480 and 518A2 cancer cell lines. Thus, the cationic ruthenium complex 4 proved to be the most selective one. In case of the neutral and cationic ruthenium complexes 1-4 the caspase-dependent apoptotic cell death was proven as the main cause of the drug's tumoricidal action on 8505C cell line.

  13. Potential of Brass to Remove Inorganic Hg(II) from Aqueous Solution through Amalgamation.

    Science.gov (United States)

    Wenke, Axel; Bollen, Anne; Richard, Jan-Helge; Biester, Harald

    2016-06-01

    Brass shavings (CuZn45) were tested for their efficiency to remove Hg(II) from contaminated groundwater through amalgamation. The study was focused on long-term retention efficiency, the understanding of the amalgamation process and kinetics, and influences of filter surface alteration. Column tests were performed with brass filters (thickness 3 to 9 cm) flushed with 1000 μg/L Hg solution for 8 hours under different flow rates (300 to 600 mL/h). Brass filters consistently removed >98% of Hg from solution independent of filter thickness and flow rate. In a long-term experiment (filter thickness 2 cm), Hg retention decreased from 96 to 92% within 2000 hours. Batch and column experiments for studying kinetics of Hg removal indicate ~100% Hg removal from solution within only 2 hours. Solid-phase mercury thermo-desorption analysis revealed that Hg(0) diffusion into the brass surface controls kinetics of mercury retention. Brass surface alteration could be observed, but did not influence Hg retention.

  14. Metabolites from invasive pests inhibit mitochondrial complex II: A potential strategy for the treatment of human ovarian carcinoma?

    Energy Technology Data Exchange (ETDEWEB)

    Ferramosca, Alessandra, E-mail: alessandra.ferramosca@unisalento.it [Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Lecce (Italy); Conte, Annalea; Guerra, Flora; Felline, Serena [Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Lecce (Italy); Rimoli, Maria Grazia [Dipartimento di Farmacia, Università di Napoli Federico II, Napoli (Italy); Mollo, Ernesto [Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli (Italy); Zara, Vincenzo [Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Lecce (Italy); Terlizzi, Antonio [Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Lecce (Italy); Stazione Zoologica Anton Dohrn, Napoli (Italy)

    2016-05-13

    The red pigment caulerpin, a secondary metabolite from the marine invasive green algae Caulerpa cylindracea can be accumulated and transferred along the trophic chain, with detrimental consequences on biodiversity and ecosystem functioning. Despite increasing research efforts to understand how caulerpin modifies fish physiology, little is known on the effects of algal metabolites on mammalian cells. Here we report for the first time the mitochondrial targeting activity of both caulerpin, and its closely related derivative caulerpinic acid, by using as experimental model rat liver mitochondria, a system in which bioenergetics mechanisms are not altered. Mitochondrial function was tested by polarographic and spectrophotometric methods. Both compounds were found to selectively inhibit respiratory complex II activity, while complexes I, III, and IV remained functional. These results led us to hypothesize that both algal metabolites could be used as antitumor agents in cell lines with defects in mitochondrial complex I. Ovarian cancer cisplatin-resistant cells are a good example of cell lines with a defective complex I function on which these molecules seem to have a toxic effect on proliferation. This provided novel insight toward the potential use of metabolites from invasive Caulerpa species for the treatment of human ovarian carcinoma cisplatin-resistant cells. -- Highlights: •Novel insight toward the potential use of the algal metabolites for the treatment of human diseases. •Caulerpin and caulerpinic acid inhibit respiratory complex II activity. •Both algal metabolites could be used as antitumor agents in ovarian cancer cisplatin-resistant cells.

  15. Metabolites from invasive pests inhibit mitochondrial complex II: A potential strategy for the treatment of human ovarian carcinoma?

    International Nuclear Information System (INIS)

    Ferramosca, Alessandra; Conte, Annalea; Guerra, Flora; Felline, Serena; Rimoli, Maria Grazia; Mollo, Ernesto; Zara, Vincenzo; Terlizzi, Antonio

    2016-01-01

    The red pigment caulerpin, a secondary metabolite from the marine invasive green algae Caulerpa cylindracea can be accumulated and transferred along the trophic chain, with detrimental consequences on biodiversity and ecosystem functioning. Despite increasing research efforts to understand how caulerpin modifies fish physiology, little is known on the effects of algal metabolites on mammalian cells. Here we report for the first time the mitochondrial targeting activity of both caulerpin, and its closely related derivative caulerpinic acid, by using as experimental model rat liver mitochondria, a system in which bioenergetics mechanisms are not altered. Mitochondrial function was tested by polarographic and spectrophotometric methods. Both compounds were found to selectively inhibit respiratory complex II activity, while complexes I, III, and IV remained functional. These results led us to hypothesize that both algal metabolites could be used as antitumor agents in cell lines with defects in mitochondrial complex I. Ovarian cancer cisplatin-resistant cells are a good example of cell lines with a defective complex I function on which these molecules seem to have a toxic effect on proliferation. This provided novel insight toward the potential use of metabolites from invasive Caulerpa species for the treatment of human ovarian carcinoma cisplatin-resistant cells. -- Highlights: •Novel insight toward the potential use of the algal metabolites for the treatment of human diseases. •Caulerpin and caulerpinic acid inhibit respiratory complex II activity. •Both algal metabolites could be used as antitumor agents in ovarian cancer cisplatin-resistant cells.

  16. Electronic structure and vibrational spectra of cis-diammine(orotato)platinum(II), a potential cisplatin analogue: DFT and experimental study

    Science.gov (United States)

    Wysokiński, Rafał; Hernik, Katarzyna; Szostak, Roman; Michalska, Danuta

    2007-03-01

    Orotic acid (vitamin B 13) is a key intermediate in biosynthesis of the pyrimidine nucleotides in living organisms, moreover, it may serve as the biological carrier for some metal ions. cis-Diammine(orotato)platinum(II), cis-[Pt(C 5H 2N 2O 4)(NH 3) 2] can be considered as a new potential cisplatin analogue. The FT-Raman and FT-IR spectra of the title complex are reported, for the first time. The molecular structure, vibrational frequencies, and the theoretical infrared and Raman intensities have been calculated by the density functional mPW1PW91 method. The detailed vibrational assignment has been made on the basis of the calculated potential energy distribution. The theoretically predicted IR and Raman spectra show very good agreement with experiment. Natural bond orbital (NBO) analyses were performed for cisplatin, carboplatin and the title complex. The results provided new data on the nature of platinum-ligand bonding in these compounds. Strong intramolecular hydrogen bond between the orotate ligand and the coordinated ammonia group stabilizes the structure of the platinum(II) complex. Thus, it is suggested that the orotate ligand in the title complex is more inert to the substitution reactions than the chloride ligands in cisplatin.

  17. Electronic structure and vibrational spectra of cis-diammine(orotato)platinum(II), a potential cisplatin analogue: DFT and experimental study

    International Nuclear Information System (INIS)

    Wysokinski, Rafal; Hernik, Katarzyna; Szostak, Roman; Michalska, Danuta

    2007-01-01

    Orotic acid (vitamin B 13 ) is a key intermediate in biosynthesis of the pyrimidine nucleotides in living organisms, moreover, it may serve as the biological carrier for some metal ions. cis-Diammine(orotato)platinum(II), cis-[Pt(C 5 H 2 N 2 O 4 )(NH 3 ) 2 ] can be considered as a new potential cisplatin analogue. The FT-Raman and FT-IR spectra of the title complex are reported, for the first time. The molecular structure, vibrational frequencies, and the theoretical infrared and Raman intensities have been calculated by the density functional mPW1PW91 method. The detailed vibrational assignment has been made on the basis of the calculated potential energy distribution. The theoretically predicted IR and Raman spectra show very good agreement with experiment. Natural bond orbital (NBO) analyses were performed for cisplatin, carboplatin and the title complex. The results provided new data on the nature of platinum-ligand bonding in these compounds. Strong intramolecular hydrogen bond between the orotate ligand and the coordinated ammonia group stabilizes the structure of the platinum(II) complex. Thus, it is suggested that the orotate ligand in the title complex is more inert to the substitution reactions than the chloride ligands in cisplatin

  18. Electronic structure and vibrational spectra of cis-diammine(orotato)platinum(II), a potential cisplatin analogue: DFT and experimental study

    Energy Technology Data Exchange (ETDEWEB)

    Wysokinski, Rafal; Hernik, Katarzyna [Faculty of Chemistry, Wroclaw University of Technology, Smoluchowskiego 23, 50-370 Wroclaw (Poland); Szostak, Roman [Faculty of Chemistry, University of Wroclaw, Joliot-Curie 14, 50-383 Wroclaw (Poland); Michalska, Danuta [Faculty of Chemistry, Wroclaw University of Technology, Smoluchowskiego 23, 50-370 Wroclaw (Poland)], E-mail: danuta.michalska@pwr.wroc.pl

    2007-03-06

    Orotic acid (vitamin B{sub 13}) is a key intermediate in biosynthesis of the pyrimidine nucleotides in living organisms, moreover, it may serve as the biological carrier for some metal ions. cis-Diammine(orotato)platinum(II), cis-[Pt(C{sub 5}H{sub 2}N{sub 2}O{sub 4})(NH{sub 3}){sub 2}] can be considered as a new potential cisplatin analogue. The FT-Raman and FT-IR spectra of the title complex are reported, for the first time. The molecular structure, vibrational frequencies, and the theoretical infrared and Raman intensities have been calculated by the density functional mPW1PW91 method. The detailed vibrational assignment has been made on the basis of the calculated potential energy distribution. The theoretically predicted IR and Raman spectra show very good agreement with experiment. Natural bond orbital (NBO) analyses were performed for cisplatin, carboplatin and the title complex. The results provided new data on the nature of platinum-ligand bonding in these compounds. Strong intramolecular hydrogen bond between the orotate ligand and the coordinated ammonia group stabilizes the structure of the platinum(II) complex. Thus, it is suggested that the orotate ligand in the title complex is more inert to the substitution reactions than the chloride ligands in cisplatin.

  19. DNA-Binding Studies of Some Potential Antitumor 2,2'-bipyridine Pt(II)/Pd(II) Complexes of piperidinedithiocarbamate. Their Synthesis, Spectroscopy and Cytotoxicity.

    Science.gov (United States)

    Mansouri-Torshizi, Hassan; Eslami-Moghadam, Mahboube; Divsalar, Adeleh; Saboury, Ali-Akbar

    2011-12-01

    In this study two platinum(II) and palladium(II) complexes of the type [M(bpy)(pip-dtc)]NO3 (where M=Pt(II) or Pd(II), bpy=2,2'-bipyridine, pip-dtc=piperidinedithiocarbamate) were synthesized by reaction between diaquo-2,2'-bipyridine Pt(II)/Pd(II) nitrate and sodium salt of dithiocarbamate. These cationic water soluble complexes were characterized by elemental analysis, molar conductance, IR, electronic and 1H NMR spectroscopic studies. The cyclic dithiocarbamate was found to coordinate as bidentate fasion with Pt(II) or Pd(II) center. Their biological activities were tested against chronic myelogenous leukemia cell line, K562, at micromolar concentration. The obtained cytotoxic concentration (IC50) values were much lower than cisplatin. The interaction of these complexes with highly polymerized calf thymus DNA (ct-DNA) was extensively studied by means of electronic absorption, fluorescence, circular dichroism and other measurements. The experimental results, thermodynamic and binding parameters, suggested that these complexes cooperatively bind to DNA presumably via intercalation. Moreover, the tendency of the Pt(II) complex to interact with DNA was more than that of Pd(II) complex.

  20. Potential-based and non-potential-based cohesive zone formulations under mixed-mode separation and over-closure-Part II: Finite element applications

    Science.gov (United States)

    Máirtín, Éamonn Ó.; Parry, Guillaume; Beltz, Glenn E.; McGarry, J. Patrick

    2014-02-01

    This paper, the second of two parts, presents three novel finite element case studies to demonstrate the importance of normal-tangential coupling in cohesive zone models (CZMs) for the prediction of mixed-mode interface debonding. Specifically, four new CZMs proposed in Part I of this study are implemented, namely the potential-based MP model and the non-potential-based NP1, NP2 and SMC models. For comparison, simulations are also performed for the well established potential-based Xu-Needleman (XN) model and the non-potential-based model of van den Bosch, Schreurs and Geers (BSG model). Case study 1: Debonding and rebonding of a biological cell from a cyclically deforming silicone substrate is simulated when the mode II work of separation is higher than the mode I work of separation at the cell-substrate interface. An active formulation for the contractility and remodelling of the cell cytoskeleton is implemented. It is demonstrated that when the XN potential function is used at the cell-substrate interface repulsive normal tractions are computed, preventing rebonding of significant regions of the cell to the substrate. In contrast, the proposed MP potential function at the cell-substrate interface results in negligible repulsive normal tractions, allowing for the prediction of experimentally observed patterns of cell cytoskeletal remodelling. Case study 2: Buckling of a coating from the compressive surface of a stent is simulated. It is demonstrated that during expansion of the stent the coating is initially compressed into the stent surface, while simultaneously undergoing tangential (shear) tractions at the coating-stent interface. It is demonstrated that when either the proposed NP1 or NP2 model is implemented at the stent-coating interface mixed-mode over-closure is correctly penalised. Further expansion of the stent results in the prediction of significant buckling of the coating from the stent surface, as observed experimentally. In contrast, the BSG model

  1. Study of diffuse H II regions potentially forming part of the gas streams around Sgr A*

    Science.gov (United States)

    Armijos-Abendaño, J.; López, E.; Martín-Pintado, J.; Báez-Rubio, A.; Aravena, M.; Requena-Torres, M. A.; Martín, S.; Llerena, M.; Aldás, F.; Logan, C.; Rodríguez-Franco, A.

    2018-05-01

    We present a study of diffuse extended ionized gas towards three clouds located in the Galactic Centre (GC). One line of sight (LOS) is towards the 20 km s-1 cloud (LOS-0.11) in the Sgr A region, another LOS is towards the 50 km s-1 cloud (LOS-0.02), also in Sgr A, while the third is towards the Sgr B2 cloud (LOS+0.693). The emission from the ionized gas is detected from Hnα and Hmβ radio recombination lines (RRLs). Henα and Hemβ RRL emission is detected with the same n and m as those from the hydrogen RRLs only towards LOS+0.693. RRLs probe gas with positive and negative velocities towards the two Sgr A sources. The Hmβ to Hnα ratios reveal that the ionized gas is emitted under local thermodynamic equilibrium conditions in these regions. We find a He to H mass fraction of 0.29±0.01 consistent with the typical GC value, supporting the idea that massive stars have increased the He abundance compared to its primordial value. Physical properties are derived for the studied sources. We propose that the negative velocity component of both Sgr A sources is part of gas streams considered previously to model the GC cloud kinematics. Associated massive stars with what are presumably the closest H II regions to LOS-0.11 (positive velocity gas), LOS-0.02, and LOS+0.693 could be the main sources of ultraviolet photons ionizing the gas. The negative velocity components of both Sgr A sources might be ionized by the same massive stars, but only if they are in the same gas stream.

  2. An analytical approach to computing biomolecular electrostatic potential. II. Validation and applications

    Science.gov (United States)

    Gordon, John C.; Fenley, Andrew T.; Onufriev, Alexey

    2008-08-01

    An ability to efficiently compute the electrostatic potential produced by molecular charge distributions under realistic solvation conditions is essential for a variety of applications. Here, the simple closed-form analytical approximation to the Poisson equation rigorously derived in Part I for idealized spherical geometry is tested on realistic shapes. The effects of mobile ions are included at the Debye-Hückel level. The accuracy of the resulting closed-form expressions for electrostatic potential is assessed through comparisons with numerical Poisson-Boltzmann (NPB) reference solutions on a test set of 580 representative biomolecular structures under typical conditions of aqueous solvation. For each structure, the deviation from the reference is computed for a large number of test points placed near the dielectric boundary (molecular surface). The accuracy of the approximation, averaged over all test points in each structure, is within 0.6 kcal/mol/|e|~kT per unit charge for all structures in the test set. For 91.5% of the individual test points, the deviation from the NPB potential is within 0.6 kcal/mol/|e|. The deviations from the reference decrease with increasing distance from the dielectric boundary: The approximation is asymptotically exact far away from the source charges. Deviation of the overall shape of a structure from ideal spherical does not, by itself, appear to necessitate decreased accuracy of the approximation. The largest deviations from the NPB reference are found inside very deep and narrow indentations that occur on the dielectric boundaries of some structures. The dimensions of these pockets of locally highly negative curvature are comparable to the size of a water molecule; the applicability of a continuum dielectric models in these regions is discussed. The maximum deviations from the NPB are reduced substantially when the boundary is smoothed by using a larger probe radius (3 A˚) to generate the molecular surface. A detailed accuracy

  3. Analysis of potential saltwater intrusion at NEP I and II power station

    International Nuclear Information System (INIS)

    Lee, D.W.

    1980-06-01

    The potential of adverse environmental impacts to groundwater availability and groundwater quality from construction dewatering of the coastal aquifer at a proposed New England Power site was examined with an analytical model. The drawdown zone and the extent of saltwater intrusion were predicted with and without the use of a slurry-wall barrier. The use of a slurry wall to mitigate any adverse impacts is feasible but the limited understanding of the coastal aquifer demands that monitoring requirements be included in the construction plan

  4. The Spectroscopic and Conductive Properties of Ru(II Complexes with Potential Anticancer Properties

    Directory of Open Access Journals (Sweden)

    Adebayo A. Adeniyi

    2014-01-01

    Full Text Available Different density functional methods (DFT have been used to optimize and study the chemistry of five potential anticancer complexes in terms of their electronic, conductive, and spectroscopic properties. Many of the computed properties in addition to the IR and QTAIM analysis of the NMR are dipole moment vector (μi, linear polarizability tensor (αij, first hyperpolarizability tensors (βijk, polarizability exaltation index (Γ, and chemical hardness (η of the complexes. Stable low energy geometries are obtained using basis set with effective core potential (ECP approximation but, in the computation of atomic or molecular properties, the metal Ru atom is better treated with higher all electron basis set like DGDZVP. The spectroscopic features like the IR of the metal-ligand bonds and the isotropic NMR shielding tensor of the coordinated atoms are significantly influenced by the chemical environment of the participating atoms. The carboxylic and pyrazole units are found to significantly enhance the polarizabilities and hyperpolarizabilities of the complexes while the chloride only improves the polarity of the complexes. Fermi contacts (FC have the highest effect followed by the PSO among all the four Ramsey terms which defined the total spin-spin coupling constant J (HZ of these complexes.

  5. Relaxation and dephasing in open quantum systems time-dependent density functional theory: Properties of exact functionals from an exactly-solvable model system

    Science.gov (United States)

    Tempel, David G.; Aspuru-Guzik, Alán

    2011-11-01

    The dissipative dynamics of many-electron systems interacting with a thermal environment has remained a long-standing challenge within time-dependent density functional theory (TDDFT). Recently, the formal foundations of open quantum systems time-dependent density functional theory (OQS-TDDFT) within the master equation approach were established. It was proven that the exact time-dependent density of a many-electron open quantum system evolving under a master equation can be reproduced with a closed (unitarily evolving) and non-interacting Kohn-Sham system. This potentially offers a great advantage over previous approaches to OQS-TDDFT, since with suitable functionals one could obtain the dissipative open-systems dynamics by simply propagating a set of Kohn-Sham orbitals as in usual TDDFT. However, the properties and exact conditions of such open-systems functionals are largely unknown. In the present article, we examine a simple and exactly-solvable model open quantum system: one electron in a harmonic well evolving under the Lindblad master equation. We examine two different representitive limits of the Lindblad equation (relaxation and pure dephasing) and are able to deduce a number of properties of the exact OQS-TDDFT functional. Challenges associated with developing approximate functionals for many-electron open quantum systems are also discussed.

  6. Anti-cancer activity and mutagenic potential of novel copper(II) quinolinone Schiff base complexes in hepatocarcinoma cells.

    Science.gov (United States)

    Duff, Brian; Thangella, Venkat Reddy; Creaven, Bernadette S; Walsh, Maureen; Egan, Denise A

    2012-08-15

    This study determined the cytotoxic, cyto-selective and mutagenic potential of novel quinolinone Schiff base ligands and their corresponding copper(II) complexes in human-derived hepatic carcinoma cells (Hep-G2) and non-malignant human-derived hepatic cells (Chang). Results indicated that complexation of quinolinone Schiff bases with copper served to significantly enhance cytotoxicity. Here, the complex of (7E)-7-(3-ethoxy-2-hydroxybenzylideamino)-4-methylquinolin-2(1H)-one (TV117-FM) exhibited the lowest IC(50) value (17.9 μM) following 96 h continuous exposure, which was comparable to cisplatin (15.0 μM). However, results revealed that TV117-FM lacked cytoselectivity over non-malignant cells. Additionally, the complex was minimally effluxed from cells via Pglycoprotein (P-gp) and was shown to be non-mutagenic in the Standard Ames test. Furthermore, BrdU incorporation assays showed that it was capable of inhibiting DNA synthesis in a concentrationand time-dependent manner. However, inhibition was not as a consequence of DNA intercalation, as illustrated in electrophoretic mobility shift assays. Interestingly, it was shown that the ligand was capable of inhibiting the action of topoisomerase II, but this was lost following complexation. This indicated that the mechanism of action of the novel copper(II) complex was different from that of the parent ligand and suggests that TV117-FM may have a therapeutic role to play in the treatment of hepatocellular carcinoma. Studies are currently underway to elucidate the exact in vitro mechanism of action of this novel, metal-based anti-cancer agent. Copyright © 2012 Elsevier B.V. All rights reserved.

  7. New Potentials for Old: The Darboux Transformation in Quantum Mechanics

    Science.gov (United States)

    Williams, Brian Wesley; Celius, Tevye C.

    2008-01-01

    The Darboux transformation in quantum mechanics is reviewed at a basic level. Examples of how this transformation leads to exactly solvable potentials related to the "particle in a box" and the harmonic oscillator are shown in detail. The connection between the Darboux transformation and some modern operator based approaches to quantum mechanics…

  8. Assessment of Nano Cellulose from Peach Palm Residue as Potential Food Additive: Part II: Preliminary Studies.

    Science.gov (United States)

    Andrade, Dayanne Regina Mendes; Mendonça, Márcia Helena; Helm, Cristiane Vieira; Magalhães, Washington L E; de Muniz, Graciela Ines Bonzon; Kestur, Satyanarayana G

    2015-09-01

    High consumption of dietary fibers in the diet is related to the reduction of the risk of non-transmitting of chronic diseases, prevention of the constipation etc. Rich diets in dietary fibers promote beneficial effects for the metabolism. Considering the above and recognizing the multifaceted advantages of nano materials, there have been many attempts in recent times to use the nano materials in the food sector including as food additive. However, whenever new product for human and animal consumption is developed, it has to be tested for their effectiveness regarding improvement in the health of consumers, safety aspects and side effects. However, before it is tried with human beings, normally such materials would be assessed through biological tests on a living organism to understand its effect on health condition of the consumer. Accordingly, based on the authors' finding reported in a previous paper, this paper presents body weight, biochemical (glucose, cholesterol and lipid profile in blood, analysis of feces) and histological tests carried out with biomass based cellulose nano fibrils prepared by the authors for its possible use as food additive. Preliminary results of the study with mice have clearly brought out potential of these fibers for the said purpose.

  9. New correlation potential for the local-spin-density functional formalism. II

    International Nuclear Information System (INIS)

    Kolar, M.; Farkas, L.

    1982-01-01

    Using the new parameterization for the correlation potential which seems to be the best that is at present available within the local-spin-density (LSD) functional formalism, the Fermi contact term in light atoms (up to Ni) is calculated. Although the overall improvement of the previous LSD results is obtained, discrepancy between theory and experiment remains rather large. It seems that the local approximation for exchange and correlation fails to predict such quantities as magnetic-moment density near the nucleus. It is also shown that the self-interaction correction does not remedy this failure. Further, the effect of the nonzero nuclear radius is investigated and found to be most important in the lightest atoms (e.g. a factor of 0.664 appears in the case of Li). This fact was omitted in all previous calculations and throws doubt on the reported excellent agreement of the results of many-body perturbation theory with experiment. It was also verified that the contact approximation of the Fermi contact term is really good enough. (author)

  10. Making oxidation potentials predictable: Coordination of additives applied to the electronic fine tuning of an iron(II) complex

    KAUST Repository

    Haslinger, Stefan

    2014-11-03

    This work examines the impact of axially coordinating additives on the electronic structure of a bioinspired octahedral low-spin iron(II) N-heterocyclic carbene (Fe-NHC) complex. Bearing two labile trans-acetonitrile ligands, the Fe-NHC complex, which is also an excellent oxidation catalyst, is prone to axial ligand exchange. Phosphine- and pyridine-based additives are used for substitution of the acetonitrile ligands. On the basis of the resulting defined complexes, predictability of the oxidation potentials is demonstrated, based on a correlation between cyclic voltammetry experiments and density functional theory calculated molecular orbital energies. Fundamental insights into changes of the electronic properties upon axial ligand exchange and the impact on related attributes will finally lead to target-oriented manipulation of the electronic properties and consequently to the effective tuning of the reactivity of bioinspired systems.

  11. Angiotensin II potentiates prostaglandin stimulation of cyclic AMP levels in intact bovine adrenal medulla cells but not adenylate cyclase in permeabilized cells.

    Science.gov (United States)

    Boarder, M R; Plevin, R; Marriott, D B

    1988-10-25

    The level of cyclic AMP in primary cultures of bovine adrenal medulla cells is elevated by prostaglandin E1. Angiotensin II is commonly reported to act on receptors linked to phosphoinositide metabolism or to inhibition of adenylate cyclase. We have investigated the effect of angiotensin II on prostaglandin E1-stimulated cyclic AMP levels in these primary cultures. Rather than reducing cyclic AMP levels, we have found that angiotensin II powerfully potentiates prostaglandin E1-stimulated cyclic AMP accumulation in intact cells, both in the presence and absence of phosphodiesterase inhibitors. The 50% maximal response was similar to that for stimulation of phosphoinositide breakdown by angiotensin II in these cultures. The potentiation of stimulated cyclic AMP levels was seen, although to a smaller maximum, with the protein kinase C (Ca2+/phospholipid-dependent enzyme) activating phorbol ester tetradecanoyl phorbolacetate and with the synthetic diacylglycerol 1-oleoyl-2-acetylglycerol; pretreatment (24 h) with active phorbol ester, which would be expected to diminish protein kinase C levels, attenuated the angiotensin II potentiation of cyclic AMP. Using digitonin-permeabilized cells we showed that adenylate cyclase activity was stimulated by prostaglandin E1 with the same dose-response relationship as was cyclic AMP accumulation in intact cells, but the permeabilized cells showed no response to angiotensin II. The results are discussed with respect to the hypothesis that the angiotensin II influence on cyclic AMP levels is mediated, in part, by diacylglycerol stimulation of protein kinase C.

  12. Metallic nanoparticles and their medicinal potential. Part II: aluminosilicates, nanobiomagnets, quantum dots and cochleates.

    Science.gov (United States)

    Loomba, Leena; Scarabelli, Tiziano

    2013-09-01

    Metallic miniaturization techniques have taken metals to nanoscale size where they can display fascinating properties and their potential applications in medicine. In recent years, metal nanoparticles such as aluminium, silicon, iron, cadmium, selenium, indium and calcium, which find their presence in aluminosilicates, nanobiomagnets, quantum dots (Q-dots) and cochleates, have caught attention of medical industries. The increasing impact of metallic nanoparticles in life sciences has significantly advanced the production techniques for these nanoparticles. In this Review, the various methods for the synthesis of nanoparticles are outlined, followed by their physicochemical properties, some recent applications in wound healing, diagnostic imaging, biosensing, assay labeling, antimicrobial activity, cancer therapy and drug delivery are listed, and finally their toxicological impacts are revised. The first half of this article describes the medicinal uses of two noble nanoparticles - gold and silver. This Review provides further information on the ability of aluminum, silicon, iron, selenium, indium, calcium and zinc to be used as nanoparticles in biomedical sciences. Aluminosilicates find their utility in wound healing and antibacterial growth. Iron-oxide nanoparticles enhance the properties of MRI contrast agents and are also used as biomagnets. Cadmium, selenium, tellurium and indium form the core nanostructures of tiny Q-dots used in cellular assay labeling, high-resolution cell imaging and biosensing. Cochleates have the bivalent nano ions calcium, magnesium or zinc imbedded in their structures and are considered to be highly effective agents for drug and gene delivery. The aluminosilicates, nanobiomagnets, Q-dots and cochleates are discussed in the light of their properties, synthesis and utility.

  13. Violation of the quantum regression theorem and the Leggett-Garg inequality in an exactly solvable model

    Science.gov (United States)

    Ban, Masashi

    2017-08-01

    Violation of the quantum regression theorem and the Leggett-Garg inequality is studied by means of the exactly solvable multi-mode Jaynes-Cummings model. An exact expression of a two-time correlation function is compared with that derived by the quantum regression theorem. It is found that the quantum regression theorem is not valid even if the reduced time evolution of the qubit is Markovian. Furthermore, it is shown that if the quantum regression theorem is applied in this model, the Leggett-Garg inequality is satisfied while it is violated by the exact correlation function.

  14. Exact Solutions of a High-Order Nonlinear Wave Equation of Korteweg-de Vries Type under Newly Solvable Conditions

    Directory of Open Access Journals (Sweden)

    Weiguo Rui

    2014-01-01

    Full Text Available By using the integral bifurcation method together with factoring technique, we study a water wave model, a high-order nonlinear wave equation of KdV type under some newly solvable conditions. Based on our previous research works, some exact traveling wave solutions such as broken-soliton solutions, periodic wave solutions of blow-up type, smooth solitary wave solutions, and nonsmooth peakon solutions within more extensive parameter ranges are obtained. In particular, a series of smooth solitary wave solutions and nonsmooth peakon solutions are obtained. In order to show the properties of these exact solutions visually, we plot the graphs of some representative traveling wave solutions.

  15. Exactly solvable quantum few-body systems associated with the symmetries of the three-dimensional and four-dimensional icosahedra

    Directory of Open Access Journals (Sweden)

    T. Scoquart, J. J. Seaward, S. G. Jackson, M. Olshanii

    2016-10-01

    Full Text Available The purpose of this article is to demonstrate that non-crystallographic reflection groups can be used to build new solvable quantum particle systems. We explicitly construct a one-parametric family of solvable four-body systems on a line, related to the symmetry of a regular icosahedron: in two distinct limiting cases the system is constrained to a half-line. We repeat the program for a 600-cell, a four-dimensional generalization of the regular three-dimensional icosahedron.

  16. Potassium currents induced by hydrostatic pressure modulate membrane potential and transmitter release in vestibular type II hair cells.

    Science.gov (United States)

    Duong Dinh, Thien An; Haasler, Thorsten; Homann, Georg; Jüngling, Eberhard; Westhofen, Martin; Lückhoff, Andreas

    2009-06-01

    Vestibular type II hair cells respond to increases in the hydrostatic pressure with pressure-dependent K(+) currents. We examined whether such currents may modulate transmitter release (assessed as membrane capacitance increments) by altering membrane potentials and voltage-gated Ca(2+) currents. Capacitance increments were dependent on voltage-gated Ca(2+) influx. Stimulating currents (0.7 nA) in current clamp induced depolarisations that were more negative by 8.7 +/- 2.1 mV when the bath height was elevated from 0.2 to 0.5 cm. In voltage clamp, protocols were used that simulated the time course of the membrane potential in current clamp at either low (control) or high hydrostatic pressure (high bath). The low bath protocol induced significantly larger Ca(2+) currents and increases in capacitance than the high bath protocol. We conclude that pressure-dependent K(+) currents may alter the voltage response of vestibular hair cells to an extent critical for Ca(2+) currents and transmitter release. This mechanism may contribute to vestibular dysfunction in Meniere's disease.

  17. Inverse modeling and uncertainty analysis of potential groundwater recharge to the confined semi-fossil Ohangwena II Aquifer, Namibia

    Science.gov (United States)

    Wallner, Markus; Houben, Georg; Lohe, Christoph; Quinger, Martin; Himmelsbach, Thomas

    2017-12-01

    The identification of potential recharge areas and estimation of recharge rates to the confined semi-fossil Ohangwena II Aquifer (KOH-2) is crucial for its future sustainable use. The KOH-2 is located within the endorheic transboundary Cuvelai-Etosha-Basin (CEB), shared by Angola and Namibia. The main objective was the development of a strategy to tackle the problem of data scarcity, which is a well-known problem in semi-arid regions. In a first step, conceptual geological cross sections were created to illustrate the possible geological setting of the system. Furthermore, groundwater travel times were estimated by simple hydraulic calculations. A two-dimensional numerical groundwater model was set up to analyze flow patterns and potential recharge zones. The model was optimized against local observations of hydraulic heads and groundwater age. The sensitivity of the model against different boundary conditions and internal structures was tested. Parameter uncertainty and recharge rates were estimated. Results indicate that groundwater recharge to the KOH-2 mainly occurs from the Angolan Highlands in the northeastern part of the CEB. The sensitivity of the groundwater model to different internal structures is relatively small in comparison to changing boundary conditions in the form of influent or effluent streams. Uncertainty analysis underlined previous results, indicating groundwater recharge originating from the Angolan Highlands. The estimated recharge rates are less than 1% of mean yearly precipitation, which are reasonable for semi-arid regions.

  18. Synthesis of Two Potentially Heptadentate (N4O3 Schiff-base Ligands Derived from Condensation of Tris(3-aminopropyl-amine and Salicylaldehyde or 4-Hydroxysalicylaldehyde. Nickel(II and Copper(II Complexes of the Former Ligand

    Directory of Open Access Journals (Sweden)

    R. V. Parish

    2002-02-01

    Full Text Available Two potentially heptadentate (N4O3 tripodal Schiff-base ligands: tris(3-(salicylideneiminopropylamine (H3L1 and tris(3-(4’-hydroxysalicylideneimino-propylamine (H3L2 have been prepared and characterized by various spectroscopic methods (IR, FAB-MS, NMR. They are derived from the condensation reactions of tris(3-aminopropylamine (tpt, with 3 equivalents of either salicylaldehyde or the ringsubstituted salicylaldehyde, 4-hydroxysalicylaldehyde. The nickel(II and copper(II complexes of H3L1 were obtained from the its reactions Ni(II and Cu(II salts in absolute methanol. These complexes were studied by IR and FAB-Mass spectrometry.

  19. Expression of endothelial monocyte-activating polypeptide II in the rat dental follicle and its potential role in tooth eruption.

    Science.gov (United States)

    Liu, Dawen; Wise, Gary E

    2008-08-01

    Endothelial monocyte-activating polypeptide II (EMAP-II) is an inflammatory cytokine with chemotactic activity. Because the dental follicle (DF) recruits mononuclear cells (osteoclast precursors) to promote the osteoclastogenesis needed for tooth eruption, it was the aim of this study to determine if EMAP-II contributes to this recruitment. Using a DNA microarray, EMAP-II was found to be highly expressed in vivo in the DFs of day 1 to day 11 postnatal rats, with its expression elevated on days 1 and 3. Use of a short interfering RNA (siRNA) to knock down EMAP-II expression resulted in a reduction in the expression of colony-stimulating factor-1 (CSF-1) and monocyte chemoattractant protein-1 (MCP-1) in the DF cells. Addition of EMAP-II protein to the DF cells partially restored the expression of CSF-1 and MCP-1. In chemotaxis assays using either conditioned medium of the DF cells with anti-(EMAP-II) immunoglobulin G added or conditioned medium of DF cells with EMAP-II knocked down by siRNA, migration indexes of bone marrow mononuclear cells were significantly reduced. These results suggest that EMAP-II is another chemotactic molecule in the dental follicle involved in the recruitment of mononuclear cells, and that EMAP-II may exert its chemotactic function directly by recruiting mononuclear cells and indirectly by enhancing the expression of other chemotactic molecules (CSF-1 and MCP-1).

  20. Structural instability of sheath potential distribution and its possible implications for the L/H transition in tokamak plasmas

    International Nuclear Information System (INIS)

    Yoshida, Zensho; Yamada, Hiroshi.

    1988-07-01

    The Bohm equation of electrostatic potential distributions in one-dimensional plasmas has been studied for various Mach numbers and plasma potentials. Solvability and structural stability have been discussed using the Sagdeev potential. Implications of the structural stability for the L/H transitions in tokamak plasmas has been also discussed. (author)

  1. Potential Role of Nitrite for Abiotic Fe(II) Oxidation and Cell Encrustation during Nitrate Reduction by Denitrifying Bacteria

    Science.gov (United States)

    Klueglein, Nicole; Zeitvogel, Fabian; Stierhof, York-Dieter; Floetenmeyer, Matthias; Konhauser, Kurt O.; Obst, Martin

    2014-01-01

    Microorganisms have been observed to oxidize Fe(II) at neutral pH under anoxic and microoxic conditions. While most of the mixotrophic nitrate-reducing Fe(II)-oxidizing bacteria become encrusted with Fe(III)-rich minerals, photoautotrophic and microaerophilic Fe(II) oxidizers avoid cell encrustation. The Fe(II) oxidation mechanisms and the reasons for encrustation remain largely unresolved. Here we used cultivation-based methods and electron microscopy to compare two previously described nitrate-reducing Fe(II) oxidizers ( Acidovorax sp. strain BoFeN1 and Pseudogulbenkiania sp. strain 2002) and two heterotrophic nitrate reducers (Paracoccus denitrificans ATCC 19367 and P. denitrificans Pd 1222). All four strains oxidized ∼8 mM Fe(II) within 5 days in the presence of 5 mM acetate and accumulated nitrite (maximum concentrations of 0.8 to 1.0 mM) in the culture media. Iron(III) minerals, mainly goethite, formed and precipitated extracellularly in close proximity to the cell surface. Interestingly, mineral formation was also observed within the periplasm and cytoplasm; intracellular mineralization is expected to be physiologically disadvantageous, yet acetate consumption continued to be observed even at an advanced stage of Fe(II) oxidation. Extracellular polymeric substances (EPS) were detected by lectin staining with fluorescence microscopy, particularly in the presence of Fe(II), suggesting that EPS production is a response to Fe(II) toxicity or a strategy to decrease encrustation. Based on the data presented here, we propose a nitrite-driven, indirect mechanism of cell encrustation whereby nitrite forms during heterotrophic denitrification and abiotically oxidizes Fe(II). This work adds to the known assemblage of Fe(II)-oxidizing bacteria in nature and complicates our ability to delineate microbial Fe(II) oxidation in ancient microbes preserved as fossils in the geological record. PMID:24271182

  2. Assessment of algorithms for computing moist available potential energy

    OpenAIRE

    Harris, Bethan L.; Tailleux, Remi

    2017-01-01

    Atmospheric moist available potential energy (MAPE) has been traditionally defined as the potential energy of a moist atmosphere relative to that of the adiabatically sorted reference state defining a global potential energy minimum. Finding such a reference state was recently shown to be a linear assignment problem, and therefore exactly solvable. However, this is computationally extremely expensive, so there has been much interest in developing heuristic methods for computing MAPE in practi...

  3. TECHNICAL REPORT ON TECHNOLOGICALLY ENHANCED NATURALLY OCCURRING RADIOACTIVE MATERIALS FROM URANIUM MINING, VOLUME II: INVESTIGATION OF POTENTIAL HEALTH, GEOGRAPHIC, AND ENVIRONMENTAL ISSUES OF ABANDONED URANIUM MINES

    Science.gov (United States)

    Volume II investigates the potential radiogenic risks from abandoned uranium mines and evaluates which may pose the greatest hazards to members of the public and to the environment. The intent of this report is to identify who may be most likely to be exposed to wastes at small a...

  4. The Marsden-Weinstein Reduction Structure of Integrable Dynamical Systems and a Generalized Exactly Solvable Quantum Superradiance Model

    Science.gov (United States)

    Bogolubov, N. N.; Prykarpatsky, Y. A.

    2013-03-01

    An approach to describing nonlinear Lax type integrable dynamical systems of modern mathematical and theoretical physics, based on the Marsden-Weinstein reduction method on canonically symplectic manifolds with group symmetry, is proposed. Its natural relationship with the well-known Adler-Kostant-Souriau-Berezin-Kirillov method and the associated R-matrix approach is analyzed. A new generalized exactly solvable spatially one-dimensional quantum superradiance model, describing a charged fermionic medium interacting with external electromagnetic field, is suggested. The Lax type operator spectral problem is presented, the related R-structure is calculated. The Hamilton operator renormalization procedure subject to a physically stable vacuum is described, the quantum excitations and quantum solitons, related with the thermodynamical equilibrity of the model, are discussed.

  5. Spin conversion of cytochrome b{sub 559} in photosystem II induced by exogenous high potential quinone

    Energy Technology Data Exchange (ETDEWEB)

    Kropacheva, Tatyana N.; Feikema, W. Onno; Mamedov, Fikret; Feyziyev, Yashar; Styring, Stenbjorn; Hoff, Arnold J

    2003-11-01

    The spin-state of cytochrome b{sub 559} (Cyt b{sub 559}) was studied in photosystem II (PSII) membrane fragments by low-temperature EPR spectroscopy. Treatment of the membranes with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) converts the native low-spin (LS) form of Cyt b{sub 559} to the high-spin (HS) form characterized with the g= 6.19 and g= 5.95 split signal. The HS Cyt b{sub 559} was pH dependent with the amplitude increasing toward more acidic pH values (pH 5.5-8.5). The HS state was not photochemically active upon 77 and 200 K continuous illumination under our conditions and was characterized by a low reduction potential ({<=}0 V). It was also demonstrated that DDQ treatment damages the oxygen evolving complex, leading to inhibition of oxygen evolution, decrease of the S{sub 2}-state EPR multiline signal and release of Mn{sup 2+}. In parallel, studies of model systems containing iron(III) protoporphyrin IX chloride (Fe{sup III}Por), which is a good model compound for the Cyt b{sub 559} prosthetic group, were performed by using optical and EPR spectroscopy. The interaction of Fe{sup III}Por with imidazole (Im) in weakly polar solvent results in formation of bis-imidazole coordinated heme iron (Fe{sup III}Por Im{sub 2}) which mimic the bis-histidine axial ligation of Cyt b{sub 559}. The reaction of DDQ with the LS Fe{sup III}Por Im{sub 2} complex leads to its transformation into the HS state (g{sub perpendicular}=5.95, g{sub parallel}=2.00). It was shown that the spin conversion occurs due to the donor-acceptor interaction of coordinated imidazole with this high-potential quinone causing the displacement of imidazole from the axial position. The similar mechanism of DDQ-induced spin change is assumed to be valid for the native membrane Cyt b{sub 559} in PSII centers.

  6. The hyperbolic step potential: Anti-bound states, SUSY partners and Wigner time delays

    Energy Technology Data Exchange (ETDEWEB)

    Gadella, M. [Departamento de Física Teórica, Atómica y Óptica and IMUVA, Universidad de Valladolid, E-47011 Valladolid (Spain); Kuru, Ş. [Department of Physics, Faculty of Science, Ankara University, 06100 Ankara (Turkey); Negro, J., E-mail: jnegro@fta.uva.es [Departamento de Física Teórica, Atómica y Óptica and IMUVA, Universidad de Valladolid, E-47011 Valladolid (Spain)

    2017-04-15

    We study the scattering produced by a one dimensional hyperbolic step potential, which is exactly solvable and shows an unusual interest because of its asymmetric character. The analytic continuation of the scattering matrix in the momentum representation has a branch cut and an infinite number of simple poles on the negative imaginary axis which are related with the so called anti-bound states. This model does not show resonances. Using the wave functions of the anti-bound states, we obtain supersymmetric (SUSY) partners which are the series of Rosen–Morse II potentials. We have computed the Wigner reflection and transmission time delays for the hyperbolic step and such SUSY partners. Our results show that the more bound states a partner Hamiltonian has the smaller is the time delay. We also have evaluated time delays for the hyperbolic step potential in the classical case and have obtained striking similitudes with the quantum case. - Highlights: • The scattering matrix of hyperbolic step potential is studied. • The scattering matrix has a branch cut and an infinite number of poles. • The poles are associated to anti-bound states. • Susy partners using antibound states are computed. • Wigner time delays for the hyperbolic step and partner potentials are compared.

  7. Anticipated tt-bar states in the quark-confining two-step potential model

    International Nuclear Information System (INIS)

    Kulshreshtha, D.S.

    1980-12-01

    The mass spectrum, thresholds and decay widths of the anticipated tt-bar states are studied as a function of quark mass, in a simple analytically solvable, quark-confining two-step potential model, previously used for charmonium and bottonium. (author)

  8. Eigenvalue spectra of a PT-symmetric coupled quartic potential in ...

    Indian Academy of Sciences (India)

    complex systems [8–10] within the framework of an extended complex phase space. Here, with the same spirit, we found the quasi-exact solutions of the Schrödinger wave equation (SE) for a generalized PT -symmetric complex quartic potential. In quantum mechanics, the quasi-exact solvable systems are those for which it ...

  9. Trapping neutral fermions with kink-like potentials

    International Nuclear Information System (INIS)

    Castro, Antonio S. de; Hott, Marcelo

    2006-01-01

    The intrinsically relativistic problem of neutral fermions subject to kink-like potentials (∼tanhγx) is investigated and the exact bound-state solutions are found. Apart from the lonely hump solutions for E=+/-mc 2 , the problem is mapped into the exactly solvable Sturm-Liouville problem with a modified Poschl-Teller potential. An apparent paradox concerning the uncertainty principle is solved by resorting to the concepts of effective mass and effective Compton wavelength

  10. A High Molar Extinction Coefficient Bisterpyridyl Homoleptic Ru(II) Complex with trans-2-Methyl-2-butenoic Acid Functionality: Potential Dye for Dye-Sensitized Solar Cells

    Science.gov (United States)

    Adeloye, Adewale O.; Olomola, Temitope O.; Adebayo, Akinbulu I.; Ajibade, Peter A.

    2012-01-01

    In our continued efforts in the synthesis of ruthenium(II) polypyridine complexes as potential dyes for use in varied applications, such as the dye-sensitized solar cells (DSSCs), this work particularly describes the synthesis, absorption spectrum, redox behavior and luminescence properties of a new homoleptic ruthenium(II) complex bearing a simple trans-2-methyl-2-butenoic acid functionality as the anchoring ligand on terpyridine moiety. The functionalized terpyridine ligand: 4′-(trans-2-methyl-2-butenoic acid)-terpyridyl (L1) was synthesized by aryl bromide substitution on terpyridine in a basic reaction condition under palladium carbide catalysis. In particular, the photophysical and redox properties of the complex formulated as: bis-4′-(trans-2-methyl-2-butenoic acid)-terpyridyl ruthenium(II) bis-hexafluorophosphate [Ru(L1)2(PF6)2] are significantly better compared to those of [Ru(tpy)2]2+ and compare well with those of the best emitters of Ru(II) polypyridine family containing tridentate ligands. Reasons for the improved photophysical and redox properties of the complex may be attributed partly to the presence of a substituted α,β-unsaturated carboxylic acid moiety leading to increase in the length of π-conjugation bond thereby enhancing the MLCT-MC (Metal-to-ligand-charge transfer-metal centred) energy gap, and to the reduced difference between the minima of the excited and ground states potential energy surfaces. PMID:22489165

  11. A High Molar Extinction Coefficient Bisterpyridyl Homoleptic Ru(II Complex with trans-2-Methyl-2-butenoic Acid Functionality: Potential Dye for Dye-Sensitized Solar Cells

    Directory of Open Access Journals (Sweden)

    Peter A. Ajibade

    2012-03-01

    Full Text Available In our continued efforts in the synthesis of ruthenium(II polypyridine complexes as potential dyes for use in varied applications, such as the dye-sensitized solar cells (DSSCs, this work particularly describes the synthesis, absorption spectrum, redox behavior and luminescence properties of a new homoleptic ruthenium(II complex bearing a simple trans-2-methyl-2-butenoic acid functionality as the anchoring ligand on terpyridine moiety. The functionalized terpyridine ligand: 4’-(trans-2-methyl-2-butenoic acid-terpyridyl (L1 was synthesized by aryl bromide substitution on terpyridine in a basic reaction condition under palladium carbide catalysis. In particular, the photophysical and redox properties of the complex formulated as: bis-4’-(trans-2-methyl-2-butenoic acid-terpyridyl ruthenium(II bis-hexafluorophosphate [Ru(L12(PF62] are significantly better compared to those of [Ru(tpy2]2+ and compare well with those of the best emitters of Ru(II polypyridine family containing tridentate ligands. Reasons for the improved photophysical and redox properties of the complex may be attributed partly to the presence of a substituted α,β-unsaturated carboxylic acid moiety leading to increase in the length of π-conjugation bond thereby enhancing the MLCT-MC (Metal-to-ligand-charge transfer-metal centred energy gap, and to the reduced difference between the minima of the excited and ground states potential energy surfaces.

  12. Evaluating Production of Cyclopentyl Tetraethers by Marine Group II Euryarchaeota in the Pearl River Estuary and Coastal South China Sea: Potential Impact on the TEX86 Paleothermometer

    Directory of Open Access Journals (Sweden)

    Jin-Xiang Wang

    2017-10-01

    Full Text Available TEX86 [TetraEther indeX of glycerol dialkyl glycerol tetraethers (GDGTs with 86 carbon atoms] has been widely applied to reconstruct (paleo- sea surface temperature. Marine Group I (MG-I Thaumarchaeota were thought to be the primary source of GDGTs constituting the TEX86 formula; however, recent research has suggested that Marine Group II (MG-II Euryarchaeota may also contribute significantly to the GDGT pool in the ocean. Little is known regarding the potential impact of MG-II Euryarchaeota-derived GDGTs on TEX86 values recorded in marine sediments. In this study, we assessed the relationship between distributions of GDGTs and MG-II Euryarchaeota and evaluated its potential effect on the TEX86 proxy. Lipid and DNA analyses were performed on suspended particulate matter and surface sediments collected along a salinity gradient from the lower Pearl River (river water and its estuary (mixing water to the coastal South China Sea (SCS, seawater. TEX86-derived temperatures from the water column and surface sediments were significantly correlated and both were lower than satellite-based temperatures. The ring index (RI values in these environments were higher than predicted from the calculated TEX86-RI correlation, indicating that the GDGT pool in the water column of the PR estuary and coastal SCS comprises relatively more cyclopentane rings, which thereby altered TEX86 values. Furthermore, the abundance of MG-II Euryarchaeota 16S rRNA gene in the mixing water was two to three orders of magnitude higher than those observed in the river or seawater. Significant linear correlations were observed between the gene abundance ratio of MG-II Euryarchaeota to total archaea and the fractional abundance of GDGTs with cyclopentane rings. Collectively, these results suggest that MG-II Euryarchaeota likely produce a large proportion of GDGTs with 1–4 cyclopentane moieties, which may bias TEX86 values in the water column and sediments. As such, valid

  13. Nickel(II) tetra-aminophthalocyanine modified MWCNTs as potential nanocomposite materials for the development of supercapacitors

    CSIR Research Space (South Africa)

    Chidembo, AT

    2010-11-01

    Full Text Available The supercapacitive properties of nickel(II) tetraaminophthalocyanine(NiTAPc)/multi-walled carbon nanotube(MWCNT) nanocomposite films have been interrogated for the first time and found to possess a maximum specific capacitance of 981 ± 57 F g-1...

  14. Effect of spin-orbit coupling on reduction potentials of octahedral ruthenium (II/III) and osmium (II/III) complexes

    Czech Academy of Sciences Publication Activity Database

    Srnec, Martin; Chalupský, Jakub; Fojta, Miroslav; Zendlová, Lucie; Havran, Luděk; Hocek, Michal; Kývala, Mojmír; Rulíšek, Lubomír

    2008-01-01

    Roč. 130, č. 33 (2008), s. 10947-10954 ISSN 0002-7863 R&D Projects: GA MŠk LC512; GA MŠk(CZ) LC06035; GA ČR GA203/05/0936; GA ČR GA203/05/0043 Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50040507 Keywords : reduction potentials * spin-orbit coupling * relativistis effects * multireference calculations Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 8.091, year: 2008

  15. Solvable model of quantum phase transitions and the symbolic-manipulation-based study of its multiply degenerate exceptional points and of their unfolding

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2013-01-01

    Roč. 336, SEP (2013), s. 98-111 ISSN 0003-4916 R&D Projects: GA ČR GAP203/11/1433 Institutional support: RVO:61389005 Keywords : Non-Hermitian quantum Hamiltonian * exceptional point * phase transition * exactly solvable model Subject RIV: BE - Theoretical Physics Impact factor: 3.065, year: 2013 http://www.sciencedirect.com/science/article/pii/S0003491613001267

  16. A new exactly solvable spatially one-dimensional quantum superradiance fermi-medium model and properties of its quantum solitonic states

    Directory of Open Access Journals (Sweden)

    D. Blackmore

    2013-06-01

    Full Text Available A new exactly solvable spatially one-dimensional quantum superradiance model describing a charged fermionic medium interacting with external electromagnetic field is proposed. The infinite hierarchy of quantuum conservation laws and many-particle Bethe eigenstates that model quantum solitonic impulse structures are constructed. The Hamilton operator renormalization procedure subject to a physically stable vacuum is described, the quantum excitations and quantum solitons, related with the thermodynamical equilibrity of the model, are discussed.

  17. Synthesis, Crystal Structure, Spectroscopic Properties and Potential Biological Activities of Salicylate‒Neocuproine Ternary Copper(II Complexes

    Directory of Open Access Journals (Sweden)

    Lenka Kucková

    2015-01-01

    Full Text Available Mixed ligand copper(II complexes containing derivatives of salicylic acid and heterocyclic ligands with nitrogen donor atoms have been the subject of various studies and reviews. In this paper, synthesis and characterization of the ternary copper(II complexes of neocuproine (2,9-dimethyl-1,10-phenanthroline, Neo and salicylate ligands (Sal are reported. In addition, the crystal structures of ([Cu(H2O(5-Cl-Sal(Neo] (1, [Cu(μ-Sal(Neo]2 (2, Cu2(μ-5-Cl-Sal(5-Cl-HSal2(Neo2]·EtOH (3 were determined. In order to compare structural and biological properties of the prepared complexes, spectroscopic and biological studies were performed. Results of X-ray diffraction show that prepared complexes form three types of crystal structures in a given system: monomeric, dimeric and dinuclear complex. The preliminary study on the DNA cleavage activity has shown that the complexes under study behave as the chemical nucleases in the presence of added hydrogen peroxide with slight differences in the activity (1 > 2 > 3. The complexes 1 and 2 exhibited nuclease activity itself indicating the interaction of complexes with the DNA. It has been proposed that the enhanced destructive effect of the complexes 1 and 2 on the DNA is a result of two possible mechanisms of action: (i the conversion of closed circular DNA (form I to the nicked DNA (form II caused by the copper complex itself and (ii damage of DNA by Reactive Oxygen Species (ROS—products of the interaction of copper with hydrogen peroxide by means of Fenton reaction (hydroxyl radicals. Thus the biological activity of the prepared Cu(II complexes containing derivatives of salicylic acid and phenanthroline molecules is substantiated by two independent mechanisms. While derivatives of salicylic acids in the coordination sphere of copper complexes are responsible for radical-scavenging activity (predominantly towards superoxide radical anion, the presence of chelating ligand 2,9-dimethyl-1,10-phenanthroline

  18. Abnormalities in auditory evoked potentials of 75 patients with Arnold-Chiari malformations types I and II Anormalidades nos potenciais evocados auditivos de 75 pacientes com os tipos I e II das malformações de Arnold-Chiari

    Directory of Open Access Journals (Sweden)

    Paulo Sergio A. Henriques Filho

    2006-09-01

    Full Text Available OBJECTIVE: To evaluate the frequency and degree of severity of abnormalities in the auditory pathways in patients with Chiari malformations type I and II. METHOD: This is a series-of-case descriptive study in which the possible presence of auditory pathways abnormalities in 75 patients (48 children and 27 adults with Chiari malformation types I and II were analyzed by means of auditory evoked potentials evaluation. The analysis was based on the determination of intervals among potentials peak values, absolute latency and amplitude ratio among potentials V and I. RESULTS: Among the 75 patients studied, 27 (36% disclosed Arnold-Chiari malformations type I and 48 (64% showed Arnold-Chiari malformations type II. Fifty-three (71% of these patients showed some degree of auditory evoked potential abnormalities. Tests were normal in the remaining 22 (29% patients. CONCLUSION: Auditory evoked potentials testing can be considered a valuable instrument for diagnosis and evaluation of brain stem functional abnormalities in patients with Arnold-Chiari malformations type I and II. The determination of the presence and degree of severity of these abnormalities can be contributory to the prevention of further handicaps in these patients either through physical therapy or by means of precocious corrective surgical intervention.OBJETIVO: Avaliar a freqüência e grau de comprometimento das vias auditivas em tronco cerebral por meio de potencial evocado auditivo, em pacientes afetados por malformações de Arnold-Chiari de tipos I e II. MÉTODO: Foi efetuado um estudo descritivo de tipo série de casos, sendo selecionados 75 pacientes (48 crianças e 27 adultos nos quais foi realizada avaliação dos potenciais evocados das vias auditivas, com base à determinação dos valores dos intervalos entre picos de potenciais, da latência absoluta e da razão entre as amplitudes dos potenciais V e I. RESULTADOS: Entre os 75 pacientes avaliados, 27 (36% apresentavam

  19. Theory of proton coupled electron transfer reactions: Assessing the Born-Oppenheimer approximation for the proton motion using an analytically solvable model

    International Nuclear Information System (INIS)

    Zheng Renhui; Jing Yuanyuan; Chen Liping; Shi Qiang

    2011-01-01

    Graphical abstract: An analytically solvable model was employed to study proton coupled electron transfer reactions. Approximated theories are assessed, and vibrational coherence is observed in case of small reorganization energy. Research highlights: → The Duschinsky rotation effect in PCET reactions. → Assessment of the BO approx. for proton motion using an analytically solvable model. → Vibrational coherence in PCET in the case of small reorganization energy. - Abstract: By employing an analytically solvable model including the Duschinsky rotation effect, we investigated the applicability of the commonly used Born-Oppenheimer (BO) approximation for separating the proton and proton donor-acceptor motions in theories of proton coupled electron transfer (PCET) reactions. Comparison with theories based on the BO approximation shows that, the BO approximation for the proton coordinate is generally valid while some further approximations may become inaccurate in certain range of parameters. We have also investigated the effect of vibrationally coherent tunneling in the case of small reorganization energy, and shown that it plays an important role on the rate constant and kinetic isotope effect.

  20. BmajPLA2-II, a basic Lys49-phospholipase A2 homologue from Bothrops marajoensis snake venom with parasiticidal potential.

    Science.gov (United States)

    Grabner, Amy N; Alfonso, Jorge; Kayano, Anderson M; Moreira-Dill, Leandro S; Dos Santos, Ana Paula de A; Caldeira, Cleópatra A S; Sobrinho, Juliana C; Gómez, Ana; Grabner, Fernando P; Cardoso, Fabio F; Zuliani, Juliana Pavan; Fontes, Marcos R M; Pimenta, Daniel C; Gómez, Celeste Vega; Teles, Carolina B G; Soares, Andreimar M; Calderon, Leonardo A

    2017-09-01

    Snake venoms contain various proteins, especially phospholipases A 2 (PLA 2 s), which present potential applications in diverse areas of health and medicine. In this study, a new basic PLA 2 from Bothrops marajoensis with parasiticidal activity was purified and characterized biochemically and biologically. B. marajoensis venom was fractionated through cation exchange followed by reverse phase chromatographies. The isolated toxin, BmajPLA 2 -II, was structurally characterized with MALDI-TOF (Matrix-assisted laser desorption/ionization-time of flight) mass spectrometry, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), followed by two-dimensional electrophoresis, partial amino acid sequencing, an enzymatic activity assay, circular dichroism, and dynamic light scattering assays. These structural characterization tests presented BmajPLA 2 -II as a basic Lys49 PLA 2 homologue, compatible with other basic snake venom PLA 2 s (svPLA 2 ), with a tendency to form aggregations. The in vitro anti-parasitic potential of B. marajoensis venom and of BmajPLA 2 -II was evaluated against Leishmania infantum promastigotes and Trypanosoma cruzi epimastigotes, showing significant activity at a concentration of 100μg/mL. The venom and BmajPLA 2 -II presented IC 50 of 0.14±0.08 and 6.41±0.64μg/mL, respectively, against intraerythrocytic forms of Plasmodium falciparum with CC 50 cytotoxicity values against HepG2 cells of 43.64±7.94 and >150μg/mL, respectively. The biotechnological potential of these substances in relation to leishmaniasis, Chagas disease and malaria should be more deeply investigated. Copyright © 2017. Published by Elsevier B.V.

  1. Antihypertensive potential and mechanism of action of astaxanthin: II. Vascular reactivity and hemorheology in spontaneously hypertensive rats.

    Science.gov (United States)

    Hussein, Ghazi; Goto, Hirozo; Oda, Shinobu; Iguchi, Tomomi; Sankawa, Ushio; Matsumoto, Kinzo; Watanabe, Hiroshi

    2005-06-01

    The current study was designed to determine the effects of a dietary astaxanthin (ASX-O) on vascular reactivity in spontaneously hypertensive rats (SHR), in order to verify its antihypertensive action mechanism. We evaluated contractions induced by phenylephrine (Phe), angiotensin II (Ang II) and the xanthine/xanthine oxidase (Xan/XOD) system, and relaxations induced by sodium nitroprusside (SNP) as well as endothelium-dependent relaxations mediated by acetylcholine (ACh) in thoracic aorta of the SHR, with and without ASX-O intervention. We also investigated the effects of ASX-O on blood rheology using a microchannel array system. In this study, ASX-O showed a significant modulatory effect on nitric oxide (NO)-induced vasorelaxation by the NO-donor SNP (pASX-O (pASX-O also demonstrated significant hemorheological effect by decreasing the microchannel transit time of whole blood. In conclusion, the results suggest that ASX-O may act in modulating the blood fluidity in hypertension, and that the antihypertensive effects of ASX-O may be exerted through mechanisms including normalization of the sensitivity of the adrenoceptor sympathetic pathway, particularly [alpha]-adrenoceptors, and by restoration of the vascular tone through attenuation of the Ang II- and reactive oxygen species (ROS)-induced vasoconstriction.

  2. Short-term inspiratory muscle training potentiates the benefits of aerobic and resistance training in patients undergoing CABG in phase II cardiac rehabilitation program.

    Science.gov (United States)

    Hermes, Bárbara Maria; Cardoso, Dannuey Machado; Gomes, Tiago José Nardi; Santos, Tamires Daros dos; Vicente, Marília Severo; Pereira, Sérgio Nunes; Barbosa, Viviane Acunha; Albuquerque, Isabella Martins de

    2015-01-01

    To investigate the efficiency of short-term inspiratory muscle training program associated with combined aerobic and resistance exercise on respiratory muscle strength, functional capacity and quality of life in patients who underwent coronary artery bypass and are in the phase II cardiac rehabilitation program. A prospective, quasi-experimental study with 24 patients who underwent coronary artery bypass and were randomly assigned to two groups in the Phase II cardiac rehabilitation program: inspiratory muscle training program associated with combined training (aerobic and resistance) group (GCR + IMT, n=12) and combined training with respiratory exercises group (GCR, n=12), over a period of 12 weeks, with two sessions per week. Before and after intervention, the following measurements were obtained: maximal inspiratory and expiratory pressures (PImax and PEmax), peak oxygen consumption (peak VO2) and quality of life scores. Data were compared between pre- and post-intervention at baseline and the variation between the pre- and post-phase II cardiac rehabilitation program using the Student's t-test, except the categorical variables, which were compared using the Chi-square test. Values of Pinspiratory muscle training, even when applied for a short period, may potentiate the effects of combined aerobic and resistance training, becoming a simple and inexpensive strategy for patients who underwent coronary artery bypass and are in phase II cardiac rehabilitation.

  3. Bioinformatics Approach Based Research of Profile Protein Carbonic Anhydrase II Analysis as a Potential Candidate Cause Autism for The Variation of Learning Subjects Biotechnology

    Directory of Open Access Journals (Sweden)

    Dian Eka A. F. Ningrum

    2017-03-01

    Full Text Available This study aims to determine the needs of learning variations on Biotechnology courses using bioinformatics approaches. One example of applied use of bioinformatics in biotechnology course is the analysis of protein profiles carbonic anhydrase II as a potential cause of autism candidate. This research is a qualitative descriptive study consisted of two phases. The first phase of the data obtained from observations of learning, student questionnaires, and questionnaires lecturer. Results from the first phase, namely the need for variations learning in Biotechnology course using bioinformatics. Collecting data on the second stage uses three webserver to predict the target protein and scientific articles. Visualization of proteins using PyMOL software. 3 based webserver which is used, the candidate of target proteins associated with autism is carbonic anhydrase II. The survey results revealed that the protein carbonic anhydrase II as a potential candidate for the cause of autism classified metaloenzim are able to bind with heavy metals. The content of heavy metals in autistic patients high that affect metabolism. This prediction of protein candidate cause autism is applied use to solve the problem in society, so that can achieve the learning outcome in biotechnology course.

  4. New quasi-exactly solvable Hermitian as well as non-Hermitian PT ...

    Indian Academy of Sciences (India)

    B. = E + a2 − 12l − 21. 4a. ,. E = 8l + 15 − a2 ±. √. (2l + 3)2 − 4a2. (9). Note that since α = β the PT symmetry is unbroken and hence, as expected, the energy eigenvalues are real. Case ii. α = β = −l. The solutions in this case can be obtained from the solutions of Case i by everywhere changing l → −l − 1. Thus in this case, ...

  5. Theoretical characterization of the potential energy surface for H + O2 yields HO2(asterisk) yields HO + O. II - The potential for H atom exchange in HO2

    Science.gov (United States)

    Walch, Stephen P.; Rohlfing, Celeste Mcmichael

    1989-01-01

    The results of CASSCF multireference contracted CI calculations with large ANO basis sets are presented for the exchange region of the HO2 potential-energy surface. The saddle point for H atom exchange is about 13 kcal/mol below the energy of H + O2; therefore, this region of the surface should be accessible during H + O2 recombination and methathesis reactions.

  6. Practice makes perfect: familiarity of task determines success in solvable tasks for free-ranging dogs (Canis lupus familiaris).

    Science.gov (United States)

    Bhattacharjee, Debottam; Dasgupta, Sandipan; Biswas, Arpita; Deheria, Jayshree; Gupta, Shreya; Nikhil Dev, N; Udell, Monique; Bhadra, Anindita

    2017-07-01

    Domestic dogs' (Canis lupus familiaris) socio-cognitive faculties have made them highly sensitive to human social cues. While dogs often excel at understanding human communicative gestures, they perform comparatively poorly in problem-solving and physical reasoning tasks. This difference in their behaviour could be due to the lifestyle and intense socialization, where problem solving and physical cognition are less important than social cognition. Free-ranging dogs live in human-dominated environments, not under human supervision and are less socialized. Being scavengers, they often encounter challenges where problem solving is required in order to get access to food. We tested Indian street dogs in familiar and unfamiliar independent solvable tasks and quantified their persistence and dependence on a novel human experimenter, in addition to their success in solving a task. Our results indicate that free-ranging dogs succeeded and persisted more in the familiar task as compared to the unfamiliar one. They showed negligible amount of human dependence in the familiar task, but showed prolonged gazing and considerable begging behaviour to the human experimenter in the context of the unfamiliar task. Cognitive abilities of free-ranging dogs thus play a pivotal role in determining task-associated behaviours based on familiarity. In addition to that, these dogs inherently tend to socialize with and depend on humans, even if they are strangers. Our results also illustrate free-ranging dogs' low competence at physical cognitive tasks.

  7. CRE Solvability, Nonlocal Symmetry and Exact Interaction Solutions of the Fifth-Order Modified Korteweg-de Vries Equation

    Science.gov (United States)

    Cheng, Wen-Guang; Qiu, De-Qin; Yu, Bo

    2017-06-01

    This paper is concerned with the fifth-order modified Korteweg-de Vries (fmKdV) equation. It is proved that the fmKdV equation is consistent Riccati expansion (CRE) solvable. Three special form of soliton-cnoidal wave interaction solutions are discussed analytically and shown graphically. Furthermore, based on the consistent tanh expansion (CTE) method, the nonlocal symmetry related to the consistent tanh expansion (CTE) is investigated, we also give the relationship between this kind of nonlocal symmetry and the residual symmetry which can be obtained with the truncated Painlevé method. We further study the spectral function symmetry and derive the Lax pair of the fmKdV equation. The residual symmetry can be localized to the Lie point symmetry of an enlarged system and the corresponding finite transformation group is computed. Supported by National Natural Science Foundation of China under Grant No. 11505090, and Research Award Foundation for Outstanding Young Scientists of Shandong Province under Grant No. BS2015SF009

  8. Metabolic flexibility of the Fe(II)-oxidizing phototropic strain Rhodopseudomonas palustris TIE1 and its potential role in microbial iron cycling

    Science.gov (United States)

    Schmidt, C.; Oswald, K.; Melton, E. D.; Kappler, A.

    2012-04-01

    The biogeochemical conversion of iron(II) and iron(III) is widespread in many aquatic and terrestrial environments. In the anoxic regime of soils and sediments the conversion and alternation of the iron redox state is predominantly run by microorganisms that are thought to gain life-sustaining energy by the oxidation and/or reduction of ferrous/ferric components. The spatial arrangement of microbial iron(II) oxidation and iron(III) reduction is largely controlled by the availability of the required electron acceptor and electron donor, as well as the essential source of energy (i.e. light or chemical energy). The physico-chemical patterns of many microbial environments undergo dynamic variations (i.e. diurnal and seasonal changes) as a function of natural external forces (i.e. seasonality, storm events, algae blooms) which strongly affects the local budget of organic carbon and nutrients, as well as the day light penetration. Such fluctuations force microorganisms either to follow the flow of substrate or to switch their metabolism to alternative electron acceptors and/or donors. Different photoferrotrophic bacteria have been shown to be able to grow either on organic (heterotrophic) or inorganic (autotrophic) substrates while exploiting light as their energy source. Within the frame of this study the preference for organic substrates (lactate and acetate) and/or ferrous iron (in simultaneous presence) for photo(ferro)trophic growth of Rhodopseudomonas palustris TIE1 has been investigated in detail. Rates of iron oxidation, acetate/lactate consumption and growth have been followed over time as a function of different lactate to acetate to iron(II) ratios. Additional experiments have been designed to evaluate the potential of Rhodopseudomonas palustris TIE1 to contribute to the redox cycling of iron. TIE1 has been grown in a batch set-up in which the iron(III)-reducing strain Shewanella oneidensis MR1 has been incubated at different ferrihydrite concentrations in

  9. Structure and biological properties of mixed-ligand Cu(II) Schiff base complexes as potential anticancer agents.

    Science.gov (United States)

    Gou, Yi; Li, Jinlong; Fan, Boyi; Xu, Bohui; Zhou, Min; Yang, Feng

    2017-07-07

    We synthesized two mixed-ligand Cu(II) complexes containing different aroylhydrazone ligands and a pyridine co-ligand, namely, [Cu(L1)(Py)] (C1) and [Cu(L2)(Py)(Br)] (C2) (L1 = (E)-2-hydroxy-N'-((2-hydroxynaphthalen-1-yl)methylene)benzohydrazide, Py = pyridine, L2 = (E)-2-hydroxy-N'-(phenyl(pyridin-2-yl)methylene)benzohydrazide), and assessed their chemical and biological properties to understand their marked activity. C2 showed better anticancer activity than C1 in various human cancer cell lines, including the cisplatin-resistant lung cancer cell line A549cisR. Both Cu(II) complexes, especially C2, displayed promising anti-metastatic activity against HepG2 cells. Spectroscopic titration and agarose gel electrophoresis experiments indicated that C2 exhibited binding affinity toward calf-thymus DNA and efficient pBR322 DNA-cleaving ability. Further mechanistic studies showed that C2 effectively induced DNA damage and thus led to cell cycle arrest at the G2/M phase, and also stimulated mitochondrial dysfunction mediated by reactive oxygen species and caspase-dependent apoptosis. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  10. The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II dependent oxygenase activity

    Directory of Open Access Journals (Sweden)

    Stiening Beate

    2004-06-01

    Full Text Available Abstract Background Apoptotic cell death plays an essential part in embryogenesis, development and maintenance of tissue homeostasis in metazoan animals. The culmination of apoptosis in vivo is the phagocytosis of cellular corpses. One morphological characteristic of cells undergoing apoptosis is loss of plasma membrane phospholipid asymmetry and exposure of phosphatidylserine on the outer leaflet. Surface exposure of phosphatidylserine is recognised by a specific receptor (phosphatidylserine receptor, PSR and is required for phagocytosis of apoptotic cells by macrophages and fibroblasts. Results We have cloned the PSR receptor from Hydra in order to investigate its function in this early metazoan. Bioinformatic analysis of the Hydra PSR protein structure revealed the presence of three nuclear localisation signals, an AT-hook like DNA binding motif and a putative 2-oxoglutarate (2OG-and Fe(II-dependent oxygenase activity. All of these features are conserved from human PSR to Hydra PSR. Expression of GFP tagged Hydra PSR in hydra cells revealed clear nuclear localisation. Deletion of one of the three NLS sequences strongly diminished nuclear localisation of the protein. Membrane localisation was never detected. Conclusions Our results suggest that Hydra PSR is a nuclear 2-oxoglutarate (2OG-and Fe(II-dependent oxygenase. This is in contrast with the proposed function of Hydra PSR as a cell surface receptor involved in the recognition of apoptotic cells displaying phosphatidylserine on their surface. The conservation of the protein from Hydra to human infers that our results also apply to PSR from higher animals.

  11. Potential application of population models in the European ecological risk assessment of chemicals. II. Review of models and their potential to address environmental protection aims.

    Science.gov (United States)

    Galic, Nika; Hommen, Udo; Baveco, J M Hans; van den Brink, Paul J

    2010-07-01

    Whereas current chemical risk assessment (RA) schemes within the European Union (EU) focus mainly on toxicity and bioaccumulation of chemicals in individual organisms, most protection goals aim at preserving populations of nontarget organisms rather than individuals. Ecological models are tools rarely recommended in official technical documents on RA of chemicals, but are widely used by researchers to assess risks to populations, communities and ecosystems. Their great advantage is the relatively straightforward integration of the sensitivity of species to chemicals, the mode of action and fate in the environment of toxicants, life-history traits of the species of concern, and landscape features. To promote the usage of ecological models in regulatory risk assessment, this study tries to establish whether existing, published ecological modeling studies have addressed or have the potential to address the protection aims and requirements of the chemical directives of the EU. We reviewed 148 publications, and evaluated and analyzed them in a database according to defined criteria. Published models were also classified in terms of 5 areas where their application would be most useful for chemical RA. All potential application areas are well represented in the published literature. Most models were developed to estimate population-level responses on the basis of individual effects, followed by recovery process assessment, both in individuals and at the level of metapopulations. We provide case studies for each of the proposed areas of ecological model application. The lack of clarity about protection goals in legislative documents made it impossible to establish a direct link between modeling studies and protection goals. Because most of the models reviewed here were not developed for regulatory risk assessment, there is great potential and a variety of ecological models in the published literature. (c) 2010 SETAC.

  12. Heavy ion beam probe investigations of plasma potential in ECRH and NBI in the TJ-II stellarator

    International Nuclear Information System (INIS)

    Melnikov, A.V.; Eliseev, L.; Perfilov, S.V.; Chmyga, A.A.; Dreval, N.; Khrebtov, S.M.; Komarov, A.D.; Kozachok, A.S.; Krupnik, L.; Alonso, A.; Pablos, J.L. de; Cappa, A.; Fernandez, A.; Fuentes, C.; Hidalgo, C.; Liniers, M.; Pedrosa, M.A.

    2005-01-01

    Direct measurements of electric potential and its fluctuations are of a primary importance in magnetic confinement systems. The Heavy Ion Beam Probe (HIBP) diagnostic is used in TJ-2 stellarator to study directly plasma electric potential profiles with spatial (up to 1cm) and temporal (up to 10 ∝s) resolution. The singly charged heavy ions Cs + with energies up to 125 keV are used to probe the plasma column from the edge to the core. Both ECRH and NBI heated plasmas (P ECRH = 200 - 400kW, P NBI = 400kW, E NBI = 28 kV) were studied. The significant improvement in the HIBP beam control system and the acquisition electronics leads us to increase the possibilities of the diagnostic. The most crucial one is the extension of the signal dynamic range, which allows us to have the reliable profiles from the plasma center to the plasma edge both in the high and low field side regions. Low density ECRH (n = 0.5-1.1.10 13 cm -3 ) plasmas in TJ-2 are characterised by core positive plasma potential of order of 500 - 1000 V and positive electric fields up to 50 V/cm. Edge radial electric fields remain positive at low densities and became negative at the threshold density that depends of plasma configuration. NBI plasmas are characterized by negative electric potential in the full plasma column and negative radial electric fields (in the range of 10 - 40 V/cm). The density rise during the NBI phase is accompanied by the decay of core plasma potential. When density is getting the level of n ∼ 2.0.10 13 cm -3 , the potential stops its evolution and remains constant. The evolution of plasma potential near density limit is under investigation. These observations, reported in different magnetic configurations, show the clear link between plasma potential and plasma density. (author)

  13. Heterosynaptic modulation of evoked synaptic potentials in layer II of the entorhinal cortex by activation of the parasubiculum.

    Science.gov (United States)

    Sparks, Daniel W; Chapman, C Andrew

    2016-08-01

    The superficial layers of the entorhinal cortex receive sensory and associational cortical inputs and provide the hippocampus with the majority of its cortical sensory input. The parasubiculum, which receives input from multiple hippocampal subfields, sends its single major output projection to layer II of the entorhinal cortex, suggesting that it may modulate processing of synaptic inputs to the entorhinal cortex. Indeed, stimulation of the parasubiculum can enhance entorhinal responses to synaptic input from the piriform cortex in vivo. Theta EEG activity contributes to spatial and mnemonic processes in this region, and the current study assessed how stimulation of the parasubiculum with either single pulses or short, five-pulse, theta-frequency trains may modulate synaptic responses in layer II entorhinal stellate neurons evoked by stimulation of layer I afferents in vitro. Parasubicular stimulation pulses or trains suppressed responses to layer I stimulation at intervals of 5 ms, and parasubicular stimulation trains facilitated layer I responses at a train-pulse interval of 25 ms. This suggests that firing of parasubicular neurons during theta activity may heterosynaptically enhance incoming sensory inputs to the entorhinal cortex. Bath application of the hyperpolarization-activated cation current (Ih) blocker ZD7288 enhanced the facilitation effect, suggesting that cholinergic inhibition of Ih may contribute. In addition, repetitive pairing of parasubicular trains and layer I stimulation induced a lasting depression of entorhinal responses to layer I stimulation. These findings provide evidence that theta activity in the parasubiculum may promote heterosynaptic modulation effects that may alter sensory processing in the entorhinal cortex. Copyright © 2016 the American Physiological Society.

  14. Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: potential role in anti-atherosclerotic activity.

    Science.gov (United States)

    Li, Hong-zhan; Lu, Yong-heng; Huang, Guang-sheng; Chen, Qi; Fu, Qiang; Li, Zhi-liang

    2014-10-01

    Antigen-presenting cells such as monocytes and dendritic cells (DCs) stimulate T-cell proliferation and activation during adaptive immunity. This cellular interaction plays a role in the growth of atherosclerotic plaques. Tanshinone II A (TSN) had been shown to decrease the growth of atherosclerotic lesions. We therefore investigated the ability of TSN to inhibit human monocyte-derived DCs and their T-cellstimulatory capacity. DCs derived from human monocytes cultured with recombinant human interleukin (IL)-4 and recombinant human granulocyte-macrophage colony-stimulating factor were co-cultured with TSN and lipopolysaccharide for 48 h. Phosphate-buffered saline was used as a negative control. Activation markers and the capacity of DCs for endocytosis were measured by flow cytometry, and proinflammatory cytokines were measured by enzyme-linked immunosorbent assays. DCs were co-cultured with lymphocytes to measure T-cell proliferation and IL-2 secretion by mixed lymphocyte reactions. TSN dose-dependently attenuated DC expression of costimulatory molecules (CD86), and decreased expression of major histocompatibility complex class II (human loukocyte antigen-DR) and adhesion molecules (CD54). Moreover, TSN reduced secretion of the proinflammatory cytokines IL-12 and IL-1 by human DCs, and restored the capacity for endocytosis. Finally, TSN-preincubated DCs showed a reduced capacity to stimulate T-cell proliferation and cytokine secretion. TSN inhibits DC maturation and decreases the expression of proinflammatory cytokines, while impairing their capacity to stimulate T-cell proliferation and cytokine secretion. These effects may contribute to the influence of TSN on the progression of atherosclerotic lesions.

  15. Methodological considerations regarding the use of inorganic {sup 197}Hg(II) radiotracer to assess mercury methylation potential rates in lake sediment

    Energy Technology Data Exchange (ETDEWEB)

    Perez Catan, Soledad [Laboratorio de Analisis por Activacion Neutronica, Comision Nacional de Energia Atomica, Centro Atomico Bariloche, 8400 Bariloche (Argentina); Guevara, Sergio Ribeiro [Laboratorio de Analisis por Activacion Neutronica, Comision Nacional de Energia Atomica, Centro Atomico Bariloche, 8400 Bariloche (Argentina)], E-mail: ribeiro@cab.cnea.gov.ar; Marvin-DiPasquale, Mark [US Geological Survey, 345 Middlefield Rd./MS 480, Menlo Park, CA 94025 (United States); Magnavacca, Cecilia [Centro Atomico Ezeiza, Comision Nacional de Energia Atomica, Presbitero Gonzalez y Aragon No. 15, B1802AYA, Ezeiza, Buenos Aires (Argentina); Cohen, Isaac Marcos [Departamento de Ingenieria Quimica, Facultad Regional Buenos Aires, Universidad Tecnologica Nacional, Medrano 951 (C1179AAQ) Buenos Aires (Argentina); Arribere, Maria [Laboratorio de Analisis por Activacion Neutronica, Comision Nacional de Energia Atomica, Centro Atomico Bariloche, 8400 Bariloche (Argentina)

    2007-09-15

    Methodological considerations on the determination of benthic methyl-mercury (CH{sub 3}Hg) production potentials were investigated on lake sediment, using {sup 197}Hg radiotracer. Three methods to arrest bacterial activity were compared: flash freezing, thermal sterilization, and {gamma}-irradiation. Flash freezing showed similar CH{sub 3}Hg recoveries as thermal sterilization, which was both 50% higher than the recoveries obtained with {gamma}-ray irradiation. No additional radiolabel was recovered in kill-control samples after an additional 24 or 65 h of incubation, suggesting that all treatments were effective at arresting Hg(II)-methylating bacterial activity, and that the initial recoveries are likely due to non-methylated {sup 197}Hg(II) carry-over in the organic extraction and/or [{sup 197}Hg]CH{sub 3}Hg produced via abiotic reactions. Two CH{sub 3}Hg extraction methods from sediment were compared: (a) direct extraction into toluene after sediment leaching with CuSO{sub 4} and HCl and (b) the same extraction with an additional back-extraction step to thiosulphate. Similar information was obtained with both methods, but the low efficiency observed and the extra work associated with the back-extraction procedure represent significant disadvantages, even tough the direct extraction involves higher Hg(II) carry over.

  16. Methodological considerations regarding the use of inorganic 197Hg(II) radiotracer to assess mercury methylation potential rates in lake sediment

    International Nuclear Information System (INIS)

    Perez Catan, Soledad; Guevara, Sergio Ribeiro; Marvin-DiPasquale, Mark; Magnavacca, Cecilia; Cohen, Isaac Marcos; Arribere, Maria

    2007-01-01

    Methodological considerations on the determination of benthic methyl-mercury (CH 3 Hg) production potentials were investigated on lake sediment, using 197 Hg radiotracer. Three methods to arrest bacterial activity were compared: flash freezing, thermal sterilization, and γ-irradiation. Flash freezing showed similar CH 3 Hg recoveries as thermal sterilization, which was both 50% higher than the recoveries obtained with γ-ray irradiation. No additional radiolabel was recovered in kill-control samples after an additional 24 or 65 h of incubation, suggesting that all treatments were effective at arresting Hg(II)-methylating bacterial activity, and that the initial recoveries are likely due to non-methylated 197 Hg(II) carry-over in the organic extraction and/or [ 197 Hg]CH 3 Hg produced via abiotic reactions. Two CH 3 Hg extraction methods from sediment were compared: (a) direct extraction into toluene after sediment leaching with CuSO 4 and HCl and (b) the same extraction with an additional back-extraction step to thiosulphate. Similar information was obtained with both methods, but the low efficiency observed and the extra work associated with the back-extraction procedure represent significant disadvantages, even tough the direct extraction involves higher Hg(II) carry over

  17. Short-term inspiratory muscle training potentiates the benefits of aerobic and resistance training in patients undergoing CABG in phase II cardiac rehabilitation program

    Directory of Open Access Journals (Sweden)

    Bárbara Maria Hermes

    2015-08-01

    Full Text Available Abstract Objective: To investigate the efficiency of short-term inspiratory muscle training program associated with combined aerobic and resistance exercise on respiratory muscle strength, functional capacity and quality of life in patients who underwent coronary artery bypass and are in the phase II cardiac rehabilitation program. Methods: A prospective, quasi-experimental study with 24 patients who underwent coronary artery bypass and were randomly assigned to two groups in the Phase II cardiac rehabilitation program: inspiratory muscle training program associated with combined training (aerobic and resistance group (GCR + IMT, n=12 and combined training with respiratory exercises group (GCR, n=12, over a period of 12 weeks, with two sessions per week. Before and after intervention, the following measurements were obtained: maximal inspiratory and expiratory pressures (PImax and PEmax, peak oxygen consumption (peak VO2 and quality of life scores. Data were compared between pre- and post-intervention at baseline and the variation between the pre- and post-phase II cardiac rehabilitation program using the Student's t-test, except the categorical variables, which were compared using the Chi-square test. Values of P<0.05 were considered statistically significant. Results: Compared to GCR, the GCR + IMT group showed larger increments in PImax (P<0.001, PEmax (P<0.001, peak VO2 (P<0.001 and quality of life scores (P<0.001. Conclusion: The present study demonstrated that the addition of inspiratory muscle training, even when applied for a short period, may potentiate the effects of combined aerobic and resistance training, becoming a simple and inexpensive strategy for patients who underwent coronary artery bypass and are in phase II cardiac rehabilitation.

  18. HLA class II polymorphisms in Spanish melanoma patients: homozygosity for HLA-DQA1 locus can be a potential melanoma risk factor.

    Science.gov (United States)

    Planelles, D; Nagore, E; Moret, A; Botella-Estrada, R; Vila, E; Guillén, C; Montoro, J A

    2006-02-01

    The association of melanoma with HLA class II loci is under extensive debate. Different investigators have found discrepant results due to, at least in part, sample size, patient series heterogeneity, choice of control population and differences in the techniques employed for the detection of HLA antigens and alleles. This study was designed to analyse the possible association of melanoma with HLA class II loci with regard to different clinic pathological factors and to investigate other risk factors for melanoma susceptibility, such as HLA homozygosity. HLA-DRB1, -DQA1 and -DQB1 genotyping was performed for 117 eastern Spanish patients presenting with primary melanoma. Although there were no significant alterations in the phenotypic frequencies of HLA-DQA1, -DQB1 or -DRB1 alleles in any subgroup of patients when compared with controls, patients exhibited a statistically significant increase in HLA-DQA1 homozygosity rate. This DQA1 homozygosity-specific association was particularly dependent on some features in melanoma patients such as light hair colour, skin type I or II, early age at diagnosis, absence of atypical naevi, or abscence of atypical naevus syndrome phenotype (aetiological fractions about 10-20%). Analysis of homozygosity for single DQA1 alleles showed an increased homozygosity rate for DQA1*0505 and DQA1*0301 in comparison with controls. These DQA1 alleles are in strong linkage disequilibrium with DQB1*0301 in white populations, and DQB1*0301 homozygous individuals were significantly increased in red in or fair-haired patients (relative risk 5.65). Our results indicate that the contribution of HLA class II alleles to primary melanoma incidence is not significant in the Spanish population. However, homozygosity for the HLA-DQA1 locus (and, perhaps, for the HLA-DQB1*0301 allele) might be considered a potential risk factor for developing melanoma depending on the person's genetic background and, perhaps, on certain environmental conditions.

  19. Synthesis, physicochemical characterization, DFT calculation and biological activities of Fe(III) and Co(II)-omeprazole complexes. Potential application in the Helicobacter pylori eradication

    Science.gov (United States)

    Russo, Marcos G.; Vega Hissi, Esteban G.; Rizzi, Alberto C.; Brondino, Carlos D.; Salinas Ibañez, Ángel G.; Vega, Alba E.; Silva, Humberto J.; Mercader, Roberto; Narda, Griselda E.

    2014-03-01

    The reaction between the antiulcer agent omeprazole (OMZ) with Fe(III) and Co(II) ions was studied, observing a high ability to form metal complexes. The isolated microcrystalline solid complexes were characterized by elemental analysis, X-ray powder diffraction (XRPD), Scanning Electron Microscopy (SEM), magnetic measurements, thermal study, FTIR, UV-Visible, Mössbauer, electronic paramagnetic resonance (EPR), and DFT calculations. The metal-ligand ratio for both complexes was 1:2 determined by elemental and thermal analysis. FTIR spectroscopy showed that OMZ acts as a neutral bidentate ligand through the pyridinic nitrogen of the benzimidazole ring and the oxygen atom of the sulfoxide group, forming a five-membered ring chelate. Electronic, Mössbauer, and EPR spectra together with magnetic measurements indicate a distorted octahedral geometry around the metal ions, where the coordination sphere is completed by two water molecules. SEM and XRPD were used to characterize the morphology and the crystal nature of the complexes. The most favorable conformation for the Fe(III)-OMZ and Co(II)-OMZ complexes was obtained by DFT calculations by using B3LYP/6-31G(d)&LanL2DZ//B3LYP/3-21G(d)&LanL2DZ basis set. Studies of solubility along with the antibacterial activity against Helicobacter pylori for OMZ and its Co(II) and Fe(III) complexes are also reported. Free OMZ and both metal complexes showed antibacterial activity against H. pylori. Co(II)-OMZ presented a minimal inhibitory concentration ˜32 times lower than that of OMZ and ˜65 lower than Fe(III)-OMZ, revealing its promising potential use for the treatment of gastric pathologies associated with the Gram negative bacteria. The morphological changes observed in the cell membrane of the bacteria after the incubation with the metal-complexes were also analyzed by SEM microscopy. The antimicrobial activity of the complexes was proved by the viability test.

  20. Entanglement entropy production in gravitational collapse: covariant regularization and solvable models

    International Nuclear Information System (INIS)

    Bianchi, Eugenio; Lorenzo, Tommaso De; Smerlak, Matteo

    2015-01-01

    We study the dynamics of vacuum entanglement in the process of gravitational collapse and subsequent black hole evaporation. In the first part of the paper, we introduce a covariant regularization of entanglement entropy tailored to curved spacetimes; this regularization allows us to propose precise definitions for the concepts of black hole “exterior entropy” and “radiation entropy.” For a Vaidya model of collapse we find results consistent with the standard thermodynamic properties of Hawking radiation. In the second part of the paper, we compute the vacuum entanglement entropy of various spherically-symmetric spacetimes of interest, including the nonsingular black hole model of Bardeen, Hayward, Frolov and Rovelli-Vidotto and the “black hole fireworks” model of Haggard-Rovelli. We discuss specifically the role of event and trapping horizons in connection with the behavior of the radiation entropy at future null infinity. We observe in particular that (i) in the presence of an event horizon the radiation entropy diverges at the end of the evaporation process, (ii) in models of nonsingular evaporation (with a trapped region but no event horizon) the generalized second law holds only at early times and is violated in the “purifying” phase, (iii) at late times the radiation entropy can become negative (i.e. the radiation can be less correlated than the vacuum) before going back to zero leading to an up-down-up behavior for the Page curve of a unitarily evaporating black hole.

  1. Solvable Catalyzed Birth-Death-Exchange Competition Model of Three Species

    International Nuclear Information System (INIS)

    Wang Haifeng; Gao Yan; Zhang Heng; Lin Zhenquan

    2009-01-01

    A competition model of three species in exchange-driven aggregation growth is proposed. In the model, three distinct aggregates grow by exchange of monomers and in parallel, birth of species A is catalyzed by species B and death of species A is catalyzed by species C. The rates for both catalysis processes are proportional to kj ν and kj ω respectively, where ν(Ω) is a parameter reflecting the dependence of the catalysis reaction rate of birth (death) on the catalyst aggregate's size. The kinetic evolution behaviors of the three species are investigated by the rate equation approach based on the mean-field theory. The form of the aggregate size distribution of A-species a k (t) is found to be dependent crucially on the two catalysis rate kernel parameters. The results show that (i) in case of μ ≤ 0, the form of a k (t) mainly depends on the competition between self-exchange of species A and species-C-catalyzed death of species A; (ii) in case of ν > 0, the form of a k (t) mainly depends on the competition between species-B-catalyzed birth of species A and species-C-catalyzed death of species A. (interdisciplinary physics and related areas of science and technology)

  2. Exactly solvable quantum state reduction models with time-dependent coupling

    International Nuclear Information System (INIS)

    Brody, Dorje C; Constantinou, Irene C; Dear, James D C; Hughston, Lane P

    2006-01-01

    A closed-form solution to the energy-based stochastic Schroedinger equation with a time-dependent coupling is obtained. The solution is algebraic in character, and is expressed directly in terms of independent random data. The data consist of (i) a random variable H which has the distribution P(H=E i ) = π i , where π i is the transition probability vertical bar (ψ 0 vertical bar Φ i ) vertical bar 2 from the initial state vertical bar ψ 0 ) to the Lueders state vertical bar Φ i ) with energy E i , and (ii) an independent P-Brownian motion, where P is the physical probability measure associated with the dynamics of the reduction process. When the coupling is time independent, it is known that state reduction occurs asymptotically-that is to say, over an infinite time horizon. In the case of a time-dependent coupling, we show that if the magnitude of the coupling decreases sufficiently rapidly, then the energy variance will be reduced under the dynamics, but the state need not reach an energy eigenstate. This situation corresponds to the case of a 'partial' or 'incomplete' measurement of the energy. We also construct an example of a model where the opposite situation prevails, in which complete state reduction is achieved after the passage of a finite period of time

  3. Entanglement entropy production in gravitational collapse: covariant regularization and solvable models

    Energy Technology Data Exchange (ETDEWEB)

    Bianchi, Eugenio [Institute for Gravitation and the Cosmos & Physics Department,Penn State, University Park, PA 16802 (United States); Lorenzo, Tommaso De [Università di Pisa, Dipartimento di Fisica “Enrico Fermi”, Largo Bruno Pontecorvo 3, 56127 Pisa (Italy); Smerlak, Matteo [Perimeter Institute for Theoretical Physics,31 Caroline St. N., Waterloo ON N2L 2Y5 (Canada)

    2015-06-25

    We study the dynamics of vacuum entanglement in the process of gravitational collapse and subsequent black hole evaporation. In the first part of the paper, we introduce a covariant regularization of entanglement entropy tailored to curved spacetimes; this regularization allows us to propose precise definitions for the concepts of black hole “exterior entropy” and “radiation entropy.” For a Vaidya model of collapse we find results consistent with the standard thermodynamic properties of Hawking radiation. In the second part of the paper, we compute the vacuum entanglement entropy of various spherically-symmetric spacetimes of interest, including the nonsingular black hole model of Bardeen, Hayward, Frolov and Rovelli-Vidotto and the “black hole fireworks” model of Haggard-Rovelli. We discuss specifically the role of event and trapping horizons in connection with the behavior of the radiation entropy at future null infinity. We observe in particular that (i) in the presence of an event horizon the radiation entropy diverges at the end of the evaporation process, (ii) in models of nonsingular evaporation (with a trapped region but no event horizon) the generalized second law holds only at early times and is violated in the “purifying” phase, (iii) at late times the radiation entropy can become negative (i.e. the radiation can be less correlated than the vacuum) before going back to zero leading to an up-down-up behavior for the Page curve of a unitarily evaporating black hole.

  4. Theoretical study of the He-HF+ complex. II. Rovibronic states from coupled diabatic potential energy surfaces

    NARCIS (Netherlands)

    Dhont, G.S.F.; Zeimen, W.B.; Groenenboom, G.C.; Avoird, A. van der

    2004-01-01

    The bound rovibronic levels of the He-HF+ complex were calculated for total angular momentum J=1/2, 3/2, 5/2, 7/2, and 9/2 with the use of ab initio diabatic intermolecular potentials presented in Paper I and the inclusion of spin-orbit coupling. The character of the rovibronic states was

  5. Pediatric cancer gone viral. Part II: potential clinical application of oncolytic herpes simplex virus-1 in children

    Directory of Open Access Journals (Sweden)

    Gregory K Friedman

    Full Text Available Oncolytic engineered herpes simplex viruses (HSVs possess many biologic and functional attributes that support their use in clinical trials in children with solid tumors. Tumor cells, in an effort to escape regulatory mechanisms that would impair their growth and progression, have removed many mechanisms that would have protected them from virus infection and eventual virus-mediated destruction. Viruses engineered to exploit this weakness, like mutant HSV, can be safely employed as tumor cell killers, since normal cells retain these antiviral strategies. Many preclinical studies and early phase trials in adults demonstrated that oncolytic HSV can be safely used and are highly effective in killing tumor cells that comprise pediatric malignancies, without generating the toxic side effects of nondiscriminatory chemotherapy or radiation therapy. A variety of engineered viruses have been developed and tested in numerous preclinical models of pediatric cancers and initial trials in patients are underway. In Part II of this review series, we examine the preclinical evidence to support the further advancement of oncolytic HSV in the pediatric population. We discuss clinical advances made to date in this emerging era of oncolytic virotherapy.

  6. Thermodynamics of information processing based on enzyme kinetics: An exactly solvable model of an information pump

    Science.gov (United States)

    Cao, Yuansheng; Gong, Zongping; Quan, H. T.

    2015-06-01

    Motivated by the recent proposed models of the information engine [Proc. Natl. Acad. Sci. USA 109, 11641 (2012), 10.1073/pnas.1204263109] and the information refrigerator [Phys. Rev. Lett. 111, 030602 (2013), 10.1103/PhysRevLett.111.030602], we propose a minimal model of the information pump and the information eraser based on enzyme kinetics. This device can either pump molecules against the chemical potential gradient by consuming the information to be encoded in the bit stream or (partially) erase the information initially encoded in the bit stream by consuming the Gibbs free energy. The dynamics of this model is solved exactly, and the "phase diagram" of the operation regimes is determined. The efficiency and the power of the information machine is analyzed. The validity of the second law of thermodynamics within our model is clarified. Our model offers a simple paradigm for the investigating of the thermodynamics of information processing involving the chemical potential in small systems.

  7. cobalt (ii), nickel (ii)

    African Journals Online (AJOL)

    DR. AMINU

    ABSTRACT. The manganese (II), cobalt (II), nickel (II) and copper (II) complexes of N, N' – bis(benzoin)ethylenediiminato have been prepared and characterized by infrared, elemental analysis, conductivity measurements and solubility. The potentiometric, and elemental analyses studies of the complexes revealed 1:1 ...

  8. Evaluation of linearly solvable Markov decision process with dynamic model learning in a mobile robot navigation task.

    Science.gov (United States)

    Kinjo, Ken; Uchibe, Eiji; Doya, Kenji

    2013-01-01

    Linearly solvable Markov Decision Process (LMDP) is a class of optimal control problem in which the Bellman's equation can be converted into a linear equation by an exponential transformation of the state value function (Todorov, 2009b). In an LMDP, the optimal value function and the corresponding control policy are obtained by solving an eigenvalue problem in a discrete state space or an eigenfunction problem in a continuous state using the knowledge of the system dynamics and the action, state, and terminal cost functions. In this study, we evaluate the effectiveness of the LMDP framework in real robot control, in which the dynamics of the body and the environment have to be learned from experience. We first perform a simulation study of a pole swing-up task to evaluate the effect of the accuracy of the learned dynamics model on the derived the action policy. The result shows that a crude linear approximation of the non-linear dynamics can still allow solution of the task, despite with a higher total cost. We then perform real robot experiments of a battery-catching task using our Spring Dog mobile robot platform. The state is given by the position and the size of a battery in its camera view and two neck joint angles. The action is the velocities of two wheels, while the neck joints were controlled by a visual servo controller. We test linear and bilinear dynamic models in tasks with quadratic and Guassian state cost functions. In the quadratic cost task, the LMDP controller derived from a learned linear dynamics model performed equivalently with the optimal linear quadratic regulator (LQR). In the non-quadratic task, the LMDP controller with a linear dynamics model showed the best performance. The results demonstrate the usefulness of the LMDP framework in real robot control even when simple linear models are used for dynamics learning.

  9. Antiferromagnetic geometric frustration under the influence of the next-nearest-neighbor interaction. An exactly solvable model

    Science.gov (United States)

    Jurčišinová, E.; Jurčišin, M.

    2018-02-01

    The influence of the next-nearest-neighbor interaction on the properties of the geometrically frustrated antiferromagnetic systems is investigated in the framework of the exactly solvable antiferromagnetic spin- 1 / 2 Ising model in the external magnetic field on the square-kagome recursive lattice, where the next-nearest-neighbor interaction is supposed between sites within each elementary square of the lattice. The thermodynamic properties of the model are investigated in detail and it is shown that the competition between the nearest-neighbor antiferromagnetic interaction and the next-nearest-neighbor ferromagnetic interaction changes properties of the single-point ground states but does not change the frustrated character of the basic model. On the other hand, the presence of the antiferromagnetic next-nearest-neighbor interaction leads to the enhancement of the frustration effects with the formation of additional plateau and single-point ground states at low temperatures. Exact expressions for magnetizations and residual entropies of all ground states of the model are found. It is shown that the model exhibits various ground states with the same value of magnetization but different macroscopic degeneracies as well as the ground states with different values of magnetization but the same value of the residual entropy. The specific heat capacity is investigated and it is shown that the model exhibits the Schottky-type anomaly behavior in the vicinity of each single-point ground state value of the magnetic field. The formation of the field-induced double-peak structure of the specific heat capacity at low temperatures is demonstrated and it is shown that its very existence is directly related to the presence of highly macroscopically degenerated single-point ground states in the model.

  10. Introducing Cobalt(II) Porphyrin/Cobalt(III) Corrole Containing Transducers for Improved Potential Reproducibility and Performance of All-Solid-State Ion-Selective Electrodes.

    Science.gov (United States)

    Jaworska, Ewa; Naitana, Mario L; Stelmach, Emilia; Pomarico, Giuseppe; Wojciechowski, Marcin; Bulska, Ewa; Maksymiuk, Krzysztof; Paolesse, Roberto; Michalska, Agata

    2017-07-05

    A novel solid contact type for all-solid-state ion-selective electrodes is introduced, yielding high stability and reproducibility of potential readings between sensors as well as improved analytical performance. The transducer phase herein proposed takes advantage of the presence of porphyrinoids containing the same metal ion at different oxidation states. In contrast to the traditional approach, the compounds of choice are not a redox pair; although they have different oxidation states, they cannot be electrochemically driven one to another. The compounds of choice were cobalt(II) porphyrin and cobalt(III) corrole-both characterized by a high stability of the coordinated metal ions in their respective redox states and electrical neutrality, as well as relatively high lipophilicity. The porphyrinoids were used together with carbon nanotubes to yield transducer layers for ion-selective electrodes. As a result, we obtained a high stability of potential readings of the resulting ion-selective electrodes together with good reproducibility between different sensor batches. Moreover, advantageously the presence of porphyrinoids in the transducer phase results in improvement of the analytical performance of the sensors: linear response range and selectivity due to interactions with membrane components, resulting in tailoring of ion fluxes through the membrane phase. Thus, carbon nanotubes with the cobalt(II) porphyrin/cobalt(III) corrole system are promising alternatives for existing transducer systems for potentiometric sensors.

  11. Path integral approach for superintegrable potentials on spaces of non-constant curvature. Pt. 1. Darboux spaces D{sub I} and D{sub II}

    Energy Technology Data Exchange (ETDEWEB)

    Grosche, C. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Pogosyan, G.S. [Joint Inst. of Nuclear Research, Moscow (Russian Federation). Bogoliubov Lab. of Theoretical Physics]|[Guadalajara Univ., Jalisco (Mexico). Dept. de Matematicas CUCEI; Sissakian, A.N. [Joint Inst. of Nuclear Research, Moscow (Russian Federation). Bogoliubov Lab. of Theoretical Physics

    2006-07-15

    In this paper the Feynman path integral technique is applied for superintegrable potentials on two-dimensional spaces of non-constant curvature: these spaces are Darboux spaces D{sub I} and D{sub II}, respectively. On D{sub I} there are three and on D{sub II} foru such potentials, respectively. We are able to evaluate the path integral in most of the separating coordinate systems, leading to expressions for the Green functions, the discrete and continuous wave-functions, and the discrete energy-spectra. In some cases, however, the discrete spectrum cannot be stated explicitly, because it is either determined by a transcendental equation involving parabolic cylinder functions (Darboux space I), or by a higher order polynomial equation. The solutions on D{sub I} in particular show that superintegrable systems are not necessarily degenerate. We can also show how the limiting cases of flat space (Constant curvature zero) and the two-dimensional hyperboloid (constant negative curvature) emerge. (Orig.)

  12. Assessment of the feasibility of studying the potential health effects of the West Valley Solidification Project. Phase II

    International Nuclear Information System (INIS)

    Matanoski, G.M.

    The activities at West Valley involve potential exposure to ionizing radiation. The health effects from radiation are well known and the projected levels of exposure in this situation are so low as to pose no known health hazard in the community. In such a situation it is not reasonable to propose an expensive, comprehensive and physically invasive screening program for the public unless one could justify the benefits. This report describes a feasible population-based surveillance or disease monitoring system which could be implemented in the West Valley area in order to assess the relevance of any changes in incidence of disease which might be attributable to radiation. The proposed plan is both practical and inexpensive. It would anticipate any potential changes in the health status of the population and provide a means to objectively interpret such changes before major concerns develop

  13. Automatic change detection in vision: Adaptation, memory mismatch, or both? II: Oddball and adaptation effects on event-related potentials.

    Science.gov (United States)

    Bodnár, Flóra; File, Domonkos; Sulykos, István; Kecskés-Kovács, Krisztina; Czigler, István

    2017-11-01

    In this study we compared the event-related potentials (ERPs) obtained in two different paradigms: a passive visual oddball paradigm and an adaptation paradigm. The aim of the study was to investigate the relation between the effects of activity decrease following an adaptor (stimulus-specific adaptation) and the effects of an infrequent stimulus within sequences of frequent ones. In Experiment 1, participants were presented with different line textures. The frequent (standard) and rare (deviant) texture elements differed in their orientation. In Experiment 2, windmill pattern stimuli were presented in which the number of vanes differentiated the deviant and standard stimuli. In Experiment 1 the ERP differences elicited between the oddball deviant and the standard were similar to the differences between the ERPs to the nonadapted and adapted stimuli in the adaptation paradigm. In both paradigms the differences appeared as a posterior negativity with the latency of 120-140 ms. This finding demonstrates that the representation of a sequential rule (successive presentation of the standard) and the violation of this rule are not necessary for deviancy effects to emerge. In Experiment 2 (windmill pattern), in the oddball paradigm the difference potentials appeared as a long-lasting negativity. In the adaptation condition, the later part of this negativity (after 200 ms) was absent. We identified the later part of the oddball difference potential as the genuine visual mismatch negativity-that is, an ERP correlate of sequence violations. The latencies of the difference potentials (deviant minus standard) and the endogenous components (P1 and N1) diverged; therefore, the adaptation of these particular ERP components cannot explain the deviancy effect. Accordingly, the sources contributing to the standard-versus-deviant modulations differed from those related to visual adaptation; that is, they generated distinct ERP components.

  14. Explore or Exploit? A Generic Model and an Exactly Solvable Case

    Science.gov (United States)

    Gueudré, Thomas; Dobrinevski, Alexander; Bouchaud, Jean-Philippe

    2014-02-01

    Finding a good compromise between the exploitation of known resources and the exploration of unknown, but potentially more profitable choices, is a general problem, which arises in many different scientific disciplines. We propose a stylized model for these exploration-exploitation situations, including population or economic growth, portfolio optimization, evolutionary dynamics, or the problem of optimal pinning of vortices or dislocations in disordered materials. We find the exact growth rate of this model for treelike geometries and prove the existence of an optimal migration rate in this case. Numerical simulations in the one-dimensional case confirm the generic existence of an optimum.

  15. Solvable spectral problems from 2d CFT and \\mathscr{N} = 2 gauge theories

    Science.gov (United States)

    Piątek, M. R.; Pietrykowski, A. R.

    2018-02-01

    The so-called 2d/4d correspondences connect two-dimensional conformal field theory (2d CFT), \\mathscr{N} = 2 supersymmetric gauge theories and quantum integrable systems. The latter in the simplest case of the SU(2) gauge group are nothing but the quantum-mechanical systems. In the present article we summarize our recent results and list open problems concerning an application of the aforementioned dualities in the studies of spectral problems for some Schrödinger operators with Mathieu-type periodic, periodic PT-symmetric and (Heun’s) elliptic potentials.

  16. HIF-1α and GLUT-1 Expression in Atypical Endometrial Hyperplasia, Type I and II Endometrial Carcinoma: A Potential Role in Pathogenesis.

    Science.gov (United States)

    Al-Sharaky, Dalia Rifaat; Abdou, Asmaa Gaber; Wahed, Moshira Mohammed Abdel; Kassem, Hend Abdou

    2016-05-01

    potential role in carcinogenesis of EC. HIF-1α may promote GLUT-1 expression in EC especially surrounding areas of necrosis. The differences between type I and type II EC regarding HIF-1α and GLUT-1 expression may confirm the differences in their aetiopathogenesis.

  17. Solvable light-front model of the electromagnetic form factor of the relativistic two-body bound state in 1+1 dimensions

    International Nuclear Information System (INIS)

    Mankiewicz, L.; Sawicki, M.

    1989-01-01

    Within a relativistically correct yet analytically solvable model of light-front quantum mechanics we construct the electromagnetic form factor of the two-body bound state and we study the validity of the static approximation to the full form factor. Upon comparison of full form factors calculated for different values of binding energy we observe an unexpected effect that for very strongly bound states further increase in binding leads to an increase in the size of the bound system. A similar effect is found for another quantum-mechanical model of relativistic dynamics

  18. Unique solvability of a non-linear non-local boundary-value problem for systems of non-linear functional differential equations

    Czech Academy of Sciences Publication Activity Database

    Dilna, N.; Rontó, András

    2010-01-01

    Roč. 60, č. 3 (2010), s. 327-338 ISSN 0139-9918 R&D Projects: GA ČR(CZ) GA201/06/0254 Institutional research plan: CEZ:AV0Z10190503 Keywords : non-linear boundary value-problem * functional differential equation * non-local condition * unique solvability * differential inequality Subject RIV: BA - General Mathematics Impact factor: 0.316, year: 2010 http://link.springer.com/article/10.2478%2Fs12175-010-0015-9

  19. Potential and flux field landscape theory. II. Non-equilibrium thermodynamics of spatially inhomogeneous stochastic dynamical systems

    International Nuclear Information System (INIS)

    Wu, Wei; Wang, Jin

    2014-01-01

    We have established a general non-equilibrium thermodynamic formalism consistently applicable to both spatially homogeneous and, more importantly, spatially inhomogeneous systems, governed by the Langevin and Fokker-Planck stochastic dynamics with multiple state transition mechanisms, using the potential-flux landscape framework as a bridge connecting stochastic dynamics with non-equilibrium thermodynamics. A set of non-equilibrium thermodynamic equations, quantifying the relations of the non-equilibrium entropy, entropy flow, entropy production, and other thermodynamic quantities, together with their specific expressions, is constructed from a set of dynamical decomposition equations associated with the potential-flux landscape framework. The flux velocity plays a pivotal role on both the dynamic and thermodynamic levels. On the dynamic level, it represents a dynamic force breaking detailed balance, entailing the dynamical decomposition equations. On the thermodynamic level, it represents a thermodynamic force generating entropy production, manifested in the non-equilibrium thermodynamic equations. The Ornstein-Uhlenbeck process and more specific examples, the spatial stochastic neuronal model, in particular, are studied to test and illustrate the general theory. This theoretical framework is particularly suitable to study the non-equilibrium (thermo)dynamics of spatially inhomogeneous systems abundant in nature. This paper is the second of a series

  20. Clonal variation in heavy metal accumulation and biomass production in a poplar coppice culture. II. Vertical distribution and phytoextraction potential

    International Nuclear Information System (INIS)

    Laureysens, I.; Temmerman, L. de; Hastir, T.; Gysel, M. van; Ceulemans, R.

    2005-01-01

    Short rotation coppice cultures (SRC) are intensively managed, high-density plantations of multi-shoot trees. In April 1996, an SRC field trial with 17 different poplar clones was established in Boom (Belgium) on a former waste disposal site. In December 1996 and January 2001, all shoots were cut back to a height of 5 cm to create a coppice culture. For six clones, wood and bark were sampled at the bottom, middle and top of a shoot in August and November 2002. No significant height effect of metal concentration was found, but for wood, metal concentrations generally increased toward the top of the shoot in August, and decreased toward the top of the shoot in November. Phytoextraction potential of a clone was primarily determined by metal concentration and by biomass production. Shoot size and number of shoots per stool were less important, as a high biomass production could be achieved by producing a few large shoots or many smaller shoots. Clone Fritzi Pauley accumulated 1.4 kg ha -1 of Al over two years; Wolterson and Balsam Spire showed a relatively high accumulation of Cd and Zn, i.e. averaging, respectively 47 and 57 g ha -1 for Cd and 2.4 and 2.0 kg ha -1 for Zn over two years. - Poplar shows potential for phytoextraction of Al, Cd and Zn on slightly contaminated soils

  1. How to get from imaginary to real chemical potential

    International Nuclear Information System (INIS)

    Karbstein, Felix; Thies, Michael

    2007-01-01

    Using the exactly solvable Gross-Neveu model as theoretical laboratory, we analyze in detail the relationship between a relativistic quantum field theory at real and imaginary chemical potential. We find that one can retrieve the full information about the phase diagram of the theory from an imaginary chemical potential calculation. The prerequisite is to evaluate and analytically continue the effective potential for the chiral order parameter, rather than thermodynamic observables or phase boundaries. In the case of an inhomogeneous phase, one needs to compute the full effective action, a functional of the space-dependent order parameter, at imaginary chemical potential

  2. Differential Induction of Long-Term Potentiation in the Horizontal versus Columnar Superficial Connections to Layer II Cells of the Entorhinal Cortex

    Directory of Open Access Journals (Sweden)

    Clayton T. Dickson

    2008-06-01

    Full Text Available The entorhinal cortex (EC is a nodal and independent mnemonic element of the medial temporal lobe memory circuit as it forms a bidirectional interface between the neocortex and hippocampus. Within the EC, intra- and inter-lamellar associational connections occur via horizontal and columnar projections, respectively. We undertook a comparative study of these two inputs as they converge upon EC layer II cells using whole-cell patch techniques in an adult rat EC horizontal slice preparation in which the deepest layers (V-VI had been dissected out. Electrical stimulation of layers I and III during GABA blockade allowed us to study excitatory synaptic properties and plasticity in the horizontal and columnar fibre systems, respectively. Both pathways exhibited AMPA- and NMDA-receptor mediated transmission and both exhibited long-term potentiation (LTP after high-frequency (tetanic stimulation. LTP in the horizontal, but not in the columnar pathway, was blocked by NMDA receptor antagonism. Intriguingly, LTP in both appeared to be mediated by post synaptic increases in Ca2+ that may be coupled to differing second messenger pathways. Thus, the superficial excitatory horizontal and columnar associative pathways to layer II have divergent mechanisms for LTP which may endow the EC with even more complex and dynamic processing characteristics than previously thought.

  3. Quality of Life Theory II. Quality of Life as the Realization of Life Potential: A Biological Theory of Human Being

    Directory of Open Access Journals (Sweden)

    Soren Ventegodt

    2003-01-01

    Full Text Available This review presents one of the eight theories of the quality of life (QOL used for making the SEQOL (self-evaluation of quality of life questionnaire or the quality of life as realizing life potential. This theory is strongly inspired by Maslow and the review furthermore serves as an example on how to fulfill the demand for an overall theory of life (or philosophy of life, which we believe is necessary for global and generic quality-of-life research.Whereas traditional medical science has often been inspired by mechanical models in its attempts to understand human beings, this theory takes an explicitly biological starting point. The purpose is to take a close view of life as a unique entity, which mechanical models are unable to do. This means that things considered to be beyond the individual's purely biological nature, notably the quality of life, meaning in life, and aspirations in life, are included under this wider, biological treatise. Our interpretation of the nature of all living matter is intended as an alternative to medical mechanism, which dates back to the beginning of the 20th century. New ideas such as the notions of the human being as nestled in an evolutionary and ecological context, the spontaneous tendency of self-organizing systems for realization and concord, and the central role of consciousness in interpreting, planning, and expressing human reality are unavoidable today in attempts to scientifically understand all living matter, including human life.

  4. Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent sodium lactate-induced panic-like response in panic-vulnerable rats.

    Science.gov (United States)

    Johnson, Philip L; Fitz, Stephanie D; Engleman, Eric A; Svensson, Kjell A; Schkeryantz, Jeffrey M; Shekhar, Anantha

    2013-02-01

    Rats with chronic inhibition of GABA synthesis by infusion of l-allyglycine, a glutamic acid decarboxylase inhibitor, into their dorsomedial/perifornical hypothalamus are anxious and exhibit panic-like cardio-respiratory responses to treatment with intravenous (i.v.) sodium lactate (NaLac) infusions, in a manner similar to what occurs in patients with panic disorder. We previously showed that either NMDA receptor antagonists or metabotropic glutamate receptor type 2/3 receptor agonists can block such a NaLac response, suggesting that a glutamate mechanism is contributing to this panic-like state. Using this animal model of panic, we tested the efficacy of CBiPES and THIIC, which are selective group II metabotropic glutamate type 2 receptor allosteric potentiators (at 10-30 mg/kg i.p.), in preventing NaLac-induced panic-like behavioral and cardiovascular responses. The positive control was alprazolam (3mg/kg i.p.), a clinically effective anti-panic benzodiazepine. As predicted, panic-prone rats given a NaLac challenge displayed NaLac-induced panic-like cardiovascular (i.e. tachycardia and hypertensive) responses and "anxiety" (i.e. decreased social interaction time) and "flight" (i.e. increased locomotion) -associated behaviors; however, systemic injection of the panic-prone rats with CBiPES, THIIC or alprazolam prior to the NaLac dose blocked all NaLac-induced panic-like behaviors and cardiovascular responses. These data suggested that in a rat animal model, selective group II metabotropic glutamate type 2 receptor allosteric potentiators show an anti-panic efficacy similar to alprazolam.

  5. Additional file 4: of MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis

    OpenAIRE

    Lipski, Deborah; Dewispelaere, RÊmi; Foucart, Vincent; Caspers, Laure; Defrance, Matthieu; Bruyns, Catherine; Willermain, François

    2017-01-01

    Figure S4. MHC class II expression in the retina during classical EAU. Three weeks after immunization, eye cryosections were prepared and stained for MHC class II (green) and IBA1 (red) or endoglin (magenta) detection. Cell nuclei were stained with Hoechst (blue). Each picture was chosen as representative of an experiment conducted on six or more animals. A. MHC class II and IBA1 expression. B. MHC class II and endoglin expression. (PPTX 7276 kb)

  6. Resistance Training in Type II Diabetes Mellitus: Impact on Areas of Metabolic Dysfunction in Skeletal Muscle and Potential Impact on Bone

    Directory of Open Access Journals (Sweden)

    Richard J. Wood

    2012-01-01

    Full Text Available The prevalence of Type II Diabetes mellitus (T2DM is increasing rapidly and will continue to be a major healthcare expenditure burden. As such, identification of effective lifestyle treatments is paramount. Skeletal muscle and bone display metabolic and functional disruption in T2DM. Skeletal muscle in T2DM is characterized by insulin resistance, impaired glycogen synthesis, impairments in mitochondria, and lipid accumulation. Bone quality in T2DM is decreased, potentially due to the effects of advanced glycation endproducts on collagen, impaired osteoblast activity, and lipid accumulation. Although exercise is widely recognized as an important component of treatment for T2DM, the focus has largely been on aerobic exercise. Emerging research suggests that resistance training (strength training may impose potent and unique benefits in T2DM. The purpose of this review is to examine the role of resistance training in treating the dysfunction in skeletal muscle and the potential role for resistance training in treating the associated dysfunction in bone.

  7. It is rocket science - why dietary nitrate is hard to 'beet'! Part II: further mechanisms and therapeutic potential of the nitrate-nitrite-NO pathway.

    Science.gov (United States)

    Mills, Charlotte Elizabeth; Khatri, Jibran; Maskell, Perry; Odongerel, Chimed; Webb, Andrew James

    2017-01-01

    Dietary nitrate (found in green leafy vegetables such as rocket and in beetroot) is now recognized to be an important source of nitric oxide, via the nitrate-nitrite-NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. Having described key twists and turns in the elucidation of the pathway and the underlying mechanisms in Part I, we explore the more recent developments which have served to confirm mechanisms, extend our understanding, and discover new properties and potential therapeutic uses of the pathway in Part II. Even the established dependency on low oxygen states for bioactivation of nitrite has recently been challenged. Dietary nitrate appears to be an important component of 'healthy diets', such as the DASH diet to lower blood pressure and the Mediterranean diet, with its potential to lower cardiovascular risk, possibly through beneficial interactions with a range of other constituents. The World Cancer Research Foundation report strong evidence for vegetables including spinach and lettuce (high nitrate-containing) decreasing cancer risk (mouth, pharynx, larynx, oesophagus and stomach), summarized in a 'Nitrate-Cancer Risk Veg-Table'. The European Space Agency recommends that beetroot, lettuce, spinach and rocket (high-nitrate vegetables) are grown to provide food for long-term space missions. Nitrate, an ancient component of rocket fuel, could support sustainable crops for healthy humans. © 2016 The British Pharmacological Society.

  8. It is rocket science – why dietary nitrate is hard to ‘beet’! Part II: further mechanisms and therapeutic potential of the nitrate‐nitrite‐NO pathway

    Science.gov (United States)

    Mills, Charlotte Elizabeth; Khatri, Jibran; Maskell, Perry; Odongerel, Chimed

    2016-01-01

    Dietary nitrate (found in green leafy vegetables such as rocket and in beetroot) is now recognized to be an important source of nitric oxide, via the nitrate‐nitrite‐NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. Having described key twists and turns in the elucidation of the pathway and the underlying mechanisms in Part I, we explore the more recent developments which have served to confirm mechanisms, extend our understanding, and discover new properties and potential therapeutic uses of the pathway in Part II. Even the established dependency on low oxygen states for bioactivation of nitrite has recently been challenged. Dietary nitrate appears to be an important component of ‘healthy diets’, such as the DASH diet to lower blood pressure and the Mediterranean diet, with its potential to lower cardiovascular risk, possibly through beneficial interactions with a range of other constituents. The World Cancer Research Foundation report strong evidence for vegetables including spinach and lettuce (high nitrate‐containing) decreasing cancer risk (mouth, pharynx, larynx, oesophagus and stomach), summarized in a ‘Nitrate‐Cancer Risk Veg‐Table’. The European Space Agency recommends that beetroot, lettuce, spinach and rocket (high‐nitrate vegetables) are grown to provide food for long‐term space missions. Nitrate, an ancient component of rocket fuel, could support sustainable crops for healthy humans. PMID:26914827

  9. Bile acids and their oxo derivatives: Potential inhibitors of carbonic anhydrase I and II, androgen receptor antagonists and CYP3A4 substrates.

    Science.gov (United States)

    Trifunović, Jovana; Borčić, Vladan; Mikov, Momir

    2017-05-01

    Some biological properties of bile acids and their oxo derivatives have not been sufficiently investigated, although the interest in bile acids as signaling molecules is rising. The aim of this work was to evaluate physico-chemical parametar b (slope) that represents the lipophilicity of the examined molecules and to investigate interactions of bile acids with carbonic anhydrase I, II, androgen receptor and CYP450s. Thirteen candidates were investigated using normal-phase thin-layer chromatography in two solvent systems. Retention parameters were used in further quantitative structure-activity relationship analysis and docking studies to predict interactions and binding affinities of examined molecules with enzymes and receptors. Prediction of activity on androgen receptor showed that compounds 3α-hydroxy-12-oxo-5β-cholanoic and 3α-hydroxy-7-oxo-5β-cholanoic acid have stronger antiandrogen activity than natural bile acids. The inhibitory potential for carbonic anhydrase I and II was tested and it was concluded that molecules 3α-hydroxy-12-oxo-5β-cholanoic, 3α-hydroxy-7-oxo-5β-cholanoic, 3,7,12-trioxo-5β-cholanoic acid and hyodeoxycholic acid show the best results. Substrate behavior for CYP3A4 was confirmed for all investigated compounds. Oxo derivatives of bile acids show stronger interactions with enzymes and receptors as classical bile acids and lower membranolytic activity compared with them. These significant observations could be valuable in consideration of oxo derivatives as building blocks in medicinal chemistry. Copyright © 2016 John Wiley & Sons, Ltd.

  10. Optimal recombination in genetic algorithms for combinatorial optimization problems: Part II

    Directory of Open Access Journals (Sweden)

    Eremeev Anton V.

    2014-01-01

    Full Text Available This paper surveys results on complexity of the optimal recombination problem (ORP, which consists in finding the best possible offspring as a result of a recombination operator in a genetic algorithm, given two parent solutions. In Part II, we consider the computational complexity of ORPs arising in genetic algorithms for problems on permutations: the Travelling Salesman Problem, the Shortest Hamilton Path Problem and the Makespan Minimization on Single Machine and some other related problems. The analysis indicates that the corresponding ORPs are NP-hard, but solvable by faster algorithms, compared to the problems they are derived from.

  11. Computational screening of Six Antigens for potential MHC class II restricted epitopes and evaluating its CD4+ T-Cell Responsiveness against Visceral Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Manas Ranjan

    2017-12-01

    Full Text Available Visceral leishmaniasis is one of the most neglected tropical diseases for which no vaccine exists. In spite of extensive efforts, no successful vaccine is available against this dreadful infectious disease. To support the vaccine development, immunoinformatics approach was applied to search for potential MHC-classII restricted epitopes that can activate the immune cells. Initially, a total of 37 epitopes derived from six, stage dependent over expressed antigens were predicted, which were presented by at least 26 diverse MHC class II alleles including: DRB10101, DRB10301, DRB10401, DRB10404, DRB10405, DRB10701, DRB10802, DRB10901, DRB11101, DRB11302, DRB11501, DRB30101, DRB40101, DRB50101, DPA10103-DPB10401, DPA10103-DPB10201, DPA10201-DPB10101, DPA10103-DPB10301_DPB10401, DPA10301-DPB10402, DPA10201-DPB105021, DQA10102-DQB10602, DQA10401-DQB10402, DQA10501-QB10201, DQA10501-DQB10301, DQA10301-DQB10302 and DQA10101-DQB10501. Based on the population coverage analysis and HLA cross presentation ability, six epitopes namely, FDLFLFSNGAVVWWG (P1, YPVYPFLASNAALLN (P2, VYPFLASNAALLNLI (P3, LALLIMLYALIATQF (P4, LIMLYALIATQFSDD (P5, IMLYALIATQFSDDA (P6 were selected for further analysis. Stimulation with synthetic peptide alone or as a cocktail triggered the intracellular IFN-γ production. Moreover, specific IgG class of antibodies was detected in the serum of active VL cases against P1, P4, P and P6 in order to evaluate peptide effect on humoral immune response. Additionally, most of the peptides, except P2, were found to be non-inducer of CD4+ IL-10 against both active VL as well as treated VL subjects. Peptide immunogenicity was validated in BALB/c mice immunized with cocktail of synthetic peptide emulsified in complete Freund’s adjuvant/incomplete Freund’s adjuvant. The immunized splenocytes induced strong spleen cell proliferation upon parasite re-stimulation. Furthermore, an increased IFN-γ, IL-12, IL-17 and IL-22 production augmented with

  12. Microwave-assisted synthesis of ruthenium(II) complexes with alkynes as potential inhibitor by selectively recognizing c-myc G-quadruplex DNA.

    Science.gov (United States)

    Zhang, Shuangyan; Wu, Qiong; Zhang, Hao; Wang, Qi; Wang, Xicheng; Mei, Wenjie; Wu, Xiaohui; Zheng, Wenjie

    2017-11-01

    Herein, two polypyridyl ruthenium(II) complexes with alkynes, [Ru(bpy) 2 L](ClO 4 ) 2 (L=p-TEPIP (1) and p-BEPIP (2); bpy=2,2'-bipyridine; p-TEPIP=2-(4-trimethylsilylpropargyl)-1H-imidazo[4,5f][1,10]phenanthroline; p-BEPIP=2-(4-phenyacetylenephenyl)-1H-imidazo[4,5f][1,10]phenanthroline) have been successfully achieved in yields of 32%-89% by a Sonogashira coupling reaction under microwave irradiation. We studied these complexes as potential stabilizers of c-myc G-quadruplex DNA. Observations revealed that both complexes could selectively bind to and stabilize c-myc G-quadruplex DNA with a constant of approximately 1.61±0.78 and 9.47±4.20×10 3 M -1 , respectively, as determined from ITC (isothermal ttitration calorimetry) experiments, FRET (fluorescence resonance energy ttransfer) assay and competitive FRET assay. Moreover, the melting point (T m ) of the c-myc G-quadruplex DNA increased in the presence of 1 and 2 ([Ru]=0.2μM) by approximately 9 and 19.9°C, respectively. It is noteworthy that the conformation of the c-myc G-quadruplex DNA appeared to change when titrated with 1 and 2, which was accompanied by a negative-induced CD (circular dichroism) signal that appeared at a wavelength of 295nm. Furthermore, the conformational change in c-myc G-quadruplex DNA induced by 1 and 2have also been confirmed by TEM (transmission electron microscopy) and AFM (atomic force microscopy). Consequently, the replication of c-myc DNA was blocked by 1 and 2, and especially by 2, as verified by PCR (polymerase chain reaction) -stop assay and Western-blot assay. Thus, these ruthenium(II) complexes can be developed as potential inhibitors in chemotherapy through their binding and stabilization of c-myc G-quadruplex DNA. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Genetic depletion of glutathione peroxidase-1 potentiates nephrotoxicity induced by multiple doses of cocaine via activation of angiotensin II AT1 receptor.

    Science.gov (United States)

    Mai, Huynh Nhu; Chung, Yoon Hee; Shin, Eun-Joo; Kim, Dae-Joong; Jeong, Ji Hoon; Nguyen, Thuy-Ty Lan; Nam, Yunsung; Lee, Yu Jeung; Nah, Seung-Yeol; Yu, Dae-Yeul; Jang, Choon-Gon; Ho, Ye-Shih; Lei, Xin Gen; Kim, Hyoung-Chun

    2016-01-01

    We investigated the possible roles of angiotensin II type 1 receptor (AT1R) and oxidative stress responsive nuclear factor κB (NFκB) in renal damage caused by multiple doses of cocaine in glutathione peroxidase (GPx)-1 gene-depleted mice. Treatment with cocaine resulted in significant increases in malondialdehyde, protein carbonyl, and pro-apoptotic Bax expression and decreases in the ratio of glutathione (GSH) and its oxidized form (GSSG), GSH-dependent enzymes, and anti-apoptotic factors in the kidney. These alterations were more pronounced in GPx-1 knockout (-/-) mice than in wild type (WT) mice. Notably, the AT1R antagonist losartan protected against the renal toxicity induced by cocaine, whereas the NFκB inhibitor pyrrolidine dithiocarbamate was not protective. The toxicity was more pronounced in GPx-1 (-/-) mice than in WT mice. The protective effect afforded by losartan against cocaine toxicity appeared to be more sensitive in GPx-1 (-/-) mice than that in WT mice. These losartan-mediated protective effects were inhibited by the phosphatidyl-inositol-3-kinase (PI3K) inhibitor LY294002, indicating that losartan provides significant protection from cocaine-induced renal toxicity through PI3K/Akt signaling. Our results suggest that genetic inhibition of GPx-1 potentiates cocaine-induced renal damage via activation of AT1R by inhibition of PI3K-Akt signaling, and that AT1R can be a therapeutic target against renal toxicity induced by cocaine.

  14. A Family of Exactly Solvable Radial Quantum Systems on Space of Non-Constant Curvature with Accidental Degeneracy in the Spectrum

    Directory of Open Access Journals (Sweden)

    Orlando Ragnisco

    2010-12-01

    Full Text Available A novel family of exactly solvable quantum systems on curved space is presented. The family is the quantum version of the classical Perlick family, which comprises all maximally superintegrable 3-dimensional Hamiltonian systems with spherical symmetry. The high number of symmetries (both geometrical and dynamical exhibited by the classical systems has a counterpart in the accidental degeneracy in the spectrum of the quantum systems. This family of quantum problem is completely solved with the techniques of the SUSYQM (supersymmetric quantum mechanics. We also analyze in detail the ordering problem arising in the quantization of the kinetic term of the classical Hamiltonian, stressing the link existing between two physically meaningful quantizations: the geometrical quantization and the position dependent mass quantization.

  15. Riproximin: A type II ribosome inactivating protein with anti-neoplastic potential induces IL24/MDA-7 and GADD genes in colorectal cancer cell lines.

    Science.gov (United States)

    Pervaiz, Asim; Adwan, Hassan; Berger, Martin R

    2015-09-01

    Riproximin (Rpx) is a type II ribosome inactivating protein, which was extracted and purified from the seeds of Ximenia americana. Previous studies demonstrated cytotoxicity of Rpx against a variety of cell lines originating from solid and non-solid cancers. In this study, we investigated the mechanistic aspects of Rpx in selected human and rat colorectal cancer (CRC) cell lines. Cytotoxic levels of Rpx were determined by MTT assay, while cytostatic and apoptotic effects were investigated by flow cytometry and nuclear staining procedures. Effects of Rpx exposure on colony formation/migration of CRC cells and expressional modulations in anticancer/stress-related genes were also studied. Rpx showed significant and comparable levels of cytotoxicity in CRC cells as determined by inhibitory concentration (IC) values. Similar inhibitory effects were found for clonogenicity, while more pronounced inhibition of migration was observed in response to Rpx exposure. Profound arrest in S phases of the cell cycle was noted especially in primary CRC cells. Apoptotic effects were more prominent in rat CRC cells as indicated by Annexin V-FITC assay and Hoechst 33342 nuclear staining. Rpx exposure induced significantly increased levels of the IL24/MDA-7, a well characterized anticancer gene, in all CRC cells. In addition, following Rpx treatment, high expression levels of growth arrest and DNA damage (GADD family) genes were also observed. Increased expression of two additional GADD genes (34 and 153) only in rat CRC cells (CC531) conferred higher sensitivity towards Rpx and subsequent anti-proliferative/apoptotic effects as compared to human CRC cells (SW480 and SW620). The present investigation indicates the anticancer potential of Rpx in CRC and favor further evaluation of this natural compound as therapeutic agent.

  16. Simple and mixed complexes of copper(II) with 8-hydroxyquinoline derivatives and amino acids: Characterization in solution and potential biological implications.

    Science.gov (United States)

    Sgarlata, Carmelo; Arena, Giuseppe; Bonomo, Raffaele P; Giuffrida, Alessandro; Tabbì, Giovanni

    2018-03-01

    Copper(II) complexes with 8-hydroxyquinoline (8-HQ) and two 8-HQ derivatives, namely clioquinol (CQ) and 5,7-dichloro-2-[(dimethylamino)methyl]quinolin-8-ol (PBT2), were investigated in organic and, where feasible, in aqueous solutions. This class of compounds is of particular interest in neurological disorders since they may act as metal-protein attenuating compounds and may help redistributing metal ions and restoring intracellular metal reserves, which are often perturbed in neurological patients. Several techniques, like potentiometry, UV-Vis absorption, electron paramagnetic resonance (EPR), cyclic voltammetry and electrospray ionisation-mass spectrometry (ESI-MS), were used to obtain information on both the formation of copper(II) complexes in solution as well as on the structure of their species. Multi-wavelength treatment of UV-Vis data clearly indicated the formation of both [Cu(PBT2)] + and [Cu(PBT2) 2 ] species; the speciation was also supported by ESI-MS data. The EPR results showed that the mono- and bis-copper(II) complexes with PBT2 have square-based pyramidal structures while the bis-copper (II) complexes with CQ or 8-HQ have square-planar o pseudo-octahedral geometries. The formation of copper(II) ternary complexes with 8-HQ, CQ and PBT2 and some selected neurotransmitters (glycine, glutamate and histidine) is also reported. Except for the copper(II) ternary complex with PBT2 and His, almost all ternary complexes have molecular geometries, which are not different from those of the bis-complexes. Interestingly the ternary copper(II) complexes, containing CQ, 8-HQ and PBT2 and glycine, glutamate or histidine turned out to be more soluble in aqueous solution than their binary complexes with parent 8-HQ derivatives; the copper(II) complexes can also be reduced more easily than their parent bis-complexes. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. A comprehensive tool for efficient design and operation of polygeneration-based energy μgrids serving a cluster of buildings. Part II: Analysis of the applicative potential

    International Nuclear Information System (INIS)

    Piacentino, Antonio; Barbaro, Chiara

    2013-01-01

    Highlights: ► A tool for the optimization of CHCP systems is applied to a four-buildings case study. ► Analyses are performed for both individual buildings and clusters of buildings. ► Effects of the width of temporal basis on results’ reliability are discussed. ► Sensitivity of plant design and operation to economic and normative provisions is studied. ► The tool reveals useful for both private investors and energy policy makers. - Abstract: The potential of polygeneration systems, in terms of profitability, energy saving and pollutant emissions reduction, highly depends on several factors such as plant efficiency, local normative and tariff conditions and reference technologies adopted to compare the results. In Part I of this paper a reliable tool was described, capable of optimizing the lay-out, design and operation of an integrated polygeneration system serving a cluster of buildings with their heat, cooling and power demand; the tool represents an excellent instrument to perform sensitivity analyses, thus enabling the analyst to formulate general design criteria and predict the effects of any change in the boundary conditions or in the normative provisions concerning support mechanisms for polygeneration plants. In this Part II of the paper, with reference to a cluster of four buildings located over a small area, once assumed a fixed topology of the site (in terms of distance between buildings) the sensitivity of plant design and operation is investigated, posing a particular focus on some context conditions: (1) the minimum primary energy saving imposed for the “high efficient cogeneration” assessment, (2) the reference efficiency of “separate power production” systems adopted to evaluate energy savings, (3) the local energy prices and (4) the incidence of tax exemption for the fuel consumed by polygeneration plants. The sensitivity analyses are preceded by an accurate study on the robustness of solutions, performed by assuming different

  18. Effect on the Inhibitory Activity of Potential Microbes on the Complexation of Methyl Anthranilate Derived Hydrazide with Cu, Ni and Zn (II) Metal Ions

    International Nuclear Information System (INIS)

    Ikram, M.; Rehman, S.; Khan, K.

    2013-01-01

    The hydrazide ligand 2-amino-(N-aminobezoyl)benzohydrazide (ABH) have been synthesized and characterized by 1H-NMR, 13C-NMR, ES+-MS, elemental analyses and infrared studies. The ligand was complexed with Ni(II), Cu(II) and Zn(II) metal ions and were characterized by analytical and spectroscopic methods including elemental analyses, ES+-MS, conductance, infrared, UV-Visible and magnetic susceptibilities studies. Infrared spectra show that the ligand form complexes through -NH2 and carbonyl moieties, the elemental studies suggested the M(ABH)X2 composition of the coordination compounds. The synthesized complexes were studied for their biological activities against gram negative bacteria including Escherichia coli, Salmonella typhi, Enterobacter aerogenes, Proteus vulgaris, Pseudomonas aeruginosa, Gram positive bacterial strains like Staphylococcus aureus and fungus like Candida albican. These activities show that the metal complexes are more active to the tested microbes as compared to neat ligand. (author)

  19. Structure-activity relationships of β-hydroxyphosphonate nucleoside analogues as cytosolic 5'-nucleotidase II potential inhibitors: synthesis, in vitro evaluation and molecular modeling studies.

    Science.gov (United States)

    Meurillon, Maïa; Marton, Zsuzsanna; Hospital, Audrey; Jordheim, Lars Petter; Béjaud, Jérôme; Lionne, Corinne; Dumontet, Charles; Périgaud, Christian; Chaloin, Laurent; Peyrottes, Suzanne

    2014-04-22

    The cytosolic 5'-nucleotidase II (cN-II) has been proposed as an attractive molecular target for the development of novel drugs circumventing resistance to cytotoxic nucleoside analogues currently used for treating leukemia and other malignant hemopathies. In the present work, synthesis of β-hydroxyphosphonate nucleoside analogues incorporating modifications either on the sugar residue or the nucleobase, and their in vitro evaluation towards the purified enzyme were carried out in order to determine their potency towards the inhibition of cN-II. In addition to the biochemical investigations, molecular modeling studies revealed important structural features for binding affinities towards the target enzyme. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  20. Study of dinuclear Rh(II) complexes of phenylalanine derivatives as potential anticancer agents by using X-ray fluorescence and X-ray absorption

    NARCIS (Netherlands)

    Majer, Zsuzsa; Bosze, Szilvia; Szabo, Ildiko; Mihucz, Victor G.; Gaal, Aniko; Szilvagyi, Gabor; Pepponi, Giancarlo; Meirer, Florian; Wobrauschek, Peter; Szoboszlai, Norbert; Ingerle, Dieter; Streli, Christina

    In vitro antitumor efficacy of several dinuclear bridgings and one chelate structure dirhodium(II) complex of N-protected phenylalanine derivatives were tested on HT-29 cells. The following synthesized and previously characterized complexes were applied in the present work: Rh-2(OAc)(4)(O-Phe-Z)(n)

  1. Characterization of monoclonal antibodies against glutamate carboxypeptidase II, the diagnostic and potential therapeutic prostate cancer marker, via the method of surface plasmon resonance

    Czech Academy of Sciences Publication Activity Database

    Tykvart, Jan; Šácha, Pavel; Konvalinka, Jan

    2012-01-01

    Roč. 279, SI suppl. 1 (2012), s. 90-90 ISSN 1742-464X. [IUBMB Congress /22./ and FEBS Congress /37./. 04.09.2012-09.09.2012, Seville] Institutional support: RVO:61388963 Keywords : glutamate carboxypeptidase II Subject RIV: CE - Biochemistry

  2. Role of intercalation and redox potential in DNA photosensitization by ruthenium(II) polypyridyl complexes: assessment using DNA repair protein tests.

    Science.gov (United States)

    Gicquel, Etienne; Souchard, Jean-Pierre; Magnusson, Fay; Chemaly, Jad; Calsou, Patrick; Vicendo, Patricia

    2013-08-01

    Here we report that the photoreactivity of ruthenium(II) complexes with nucleobases may not only be modulated by their photoredox properties but also by their DNA binding mode. The damage resulting from photolysis of synthetic oligonucleotides and plasmid DNA by [Ru(bpz)3](2+), [Ru(bipy)3](2+) and the two DNA intercalating agents [Ru(bpz)2dppz](2+) and [Ru(bipy)2dppz](2+) has been monitored by polyacrylamide gel electrophoresis and by tests using proteins involved in DNA repair processes (DNA-PKCs, Ku80, Ku70, and PARP-1). The data show that intercalation controls the nature of the DNA damage photo-induced by ruthenium(II) complexes reacting with DNA via an electron transfer process. The intercalating agent [Ru(bpz)2dppz](2+) is a powerful DNA breaker inducing the formation of both single and double (DSBs) strand breaks which are recognized by the PARP-1 and DNA-PKCs proteins respectively. [Ru(bpz)2dppz](2+) is the first ruthenium(II) complex described in the literature that is able to induce DSBs by an electron transfer process. In contrast, its non-intercalating parent compound, [Ru(bpz)3](2+), is mostly an efficient DNA alkylating agent. Photoadducts are recognized by the proteins Ku70 and Ku80 as with cisplatin adducts. This result suggests that photoaddition of [Ru(bpz)2dppz](2+) is strongly affected by its DNA intercalation whereas its photonuclease activity is exalted. The data clearly show that DNA intercalation decreases drastically the photonuclease activity of ruthenium(II) complexes oxidizing guanine via the production of singlet oxygen. Interestingly, the DNA sequencing data revealed that the ligand dipyridophenazine exhibits on single-stranded oligonucleotides a preference for the 5'-TGCGT-3' sequence. Moreover the use of proteins involved in DNA repair processes to detect DNA damage was a powerful tool to examine the photoreactivity of ruthenium(II) complexes with nucleic acids.

  3. Synthesis and electrochemistry of β-pyrrole nitro-substituted cobalt(II) porphyrins. The effect of the NO₂ group on redox potentials, the electron transfer mechanism and catalytic reduction of molecular oxygen in acidic media.

    Science.gov (United States)

    Sun, Bin; Ou, Zhongping; Yang, Shuibo; Meng, Deying; Lu, Guifen; Fang, Yuanyuan; Kadish, Karl M

    2014-07-28

    Four cobalt(II) porphyrins, two of which contain a β-pyrrole nitro substituent, were synthesized and characterized by electrochemistry and spectroelectrochemistry. The investigated compounds are represented as (TRPP)Co and (NO2TRPP)Co, where TRPP is the dianion of a substituted tetraphenylporphyrin and R is a CH3 or OCH3 substituent on the four phenyl rings of the macrocycle. Two reductions and three oxidations are observed for each compound in CH2Cl2 containing 0.10 M tetra-n-butylammonium perchlorate. The first reduction of the compounds without a nitro substituent is metal-centered and leads to formation of a Co(I) porphyrin which then reacts with the CH2Cl2 solvent to generate a carbon σ-bonded Co(III)-R complex. A further reduction then occurs at more negative potentials to generate an unstable Co(II) σ-bonded compound. In contrast to these reactions, the first reduction of the nitro-substituted porphyrins is macrocycle-centered under the same solution conditions and gives a Co(II) porphyrin π-anion radical product. This reversible electron transfer is then followed at more negative potentials by a second reversible one-electron addition to give a Co(II) dianion. Three reversible one-electron oxidations are also seen for each compound. The first is metal-centered and the next two involve the conjugated π-system of the macrocycle. Each neutral Co(II) porphyrin was also examined as to its catalytic activity for electroreduction of molecular oxygen when coated on an edge-plane pyrolytic graphite electrode in 1.0 M HClO4. The β-pyrrole nitro-substituted derivatives were shown to be better catalysts than the non-nitro substituted compounds under the utilized experimental conditions.

  4. Rhodium (II) cycle alkanecarboxylate: synthesis, spectroscopic and thermo analytic studies and evaluation of the antitumor potential; Cicloalcanocarboxilatos de rodio(II). Sintese, estudos espectroscopicos, termoanaliticos e avaliacao do potencial antitumor

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Aparecido Ribeiro de

    1995-07-01

    Four new rhodium(II) carboxylates (cyclopropane, cyclobutane, cyclopentane, and cyclohexanecarboxylate), and other already known rhodium (II) carboxylates (acetate, propionate, butyrate, metoxyacetate, dichloroacetate, and trifluoroacetate), have been prepared for study in this work. The compounds were characterized by elementary and thermogravimetric analysis, magnetic susceptibility, and electronic, Raman, and infrared spectroscopy. The reaction of Rh CL{sub 3}.aq with the sodium carboxylates was studied aiming to improve the understanding of the redox process involved. Spectroscopy studies (Raman and electronic) were made to examine the transition involved in the Rh-Rh and Rh-O bonds. The results have shown a direct relation between the force of the carboxylic acid and the Rh-O force, but show a inverse relation with the Rh-Rh bond force. Thermal analysis studies were undertaken and the obtained date show a resemblance of the TG/DTG curves with that found in literature. In the other hand, the DSC curves show a different results: in open crucible, the peaks associated with the cage breakdown are exothermic and, in closed crucible this peaks are endothermic. The thermodecomposition products were analyzed. The evolved gases were identified by GC?MS and {sup 1}H and {sup 13} C NMR spectra. The residues were analyzed by X-ray diffraction. Antitumor activity of rhodium cyclopropanecarboxylate was evaluated in vitro (cell cultures K562 and Ehrlich) and in vivo (Balb-c mice with ascite Ehrlich tumor), indicating an increased life span (87.5%) of the treated animals. (author)

  5. A potentially critical Hpa II site of the X chromosome-linked PGK1 gene is unmethylated prior to the onset of meiosis of human oogenic cells

    Energy Technology Data Exchange (ETDEWEB)

    Singer-Sam, J.; Dai, A.; Riggs, A.D. (Beckman Research Inst., Duarte, CA (United States)); Goldstein, L.; Gartler, S.M. (Univ. of Washington, Seattle (United States))

    1992-02-15

    Hpa II site H8 is in the CpG-rich 5{prime} untranslated region of the human X chromosome-linked gene for phosphoglycerate kinase 1 (PGK1). It is the only Hpa II site in the CpG island' whose methylation pattern is perfectly correlated with transcriptional silence of this gene. The authors measured DNA methylation at site H8 in fetal oogonia and oocytes and found, using a quantitative assay based on the polymerase chain reaction, that purified germ cells isolated by micromanipulation were unmethylated in 47-day to 110-day fetuses, whereas ovaries depleted of germ cells and non-ovary tissues were methylated. They conclude that site H8 is the unmethylated in germ cells prior to the onset of meiosis and reactivation of the X chromosome.

  6. Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease

    OpenAIRE

    Murphy, Caitlin C.; Sanoff, Hanna K.; Stitzenberg, Karyn B.; Baron, John A.; Lund, Jennifer L.; Sandler, Robert S.

    2017-01-01

    Background and Aims. As a first step toward understanding the increasing incidence of colorectal cancer (CRC) in younger (age < 50) populations, we examined demographic, clinicopathologic, and socioeconomic characteristics and treatment receipt in a population-based sample of patients newly diagnosed with stages II and III CRC. Methods. Patients were sampled from the National Cancer Institute's Patterns of Care studies in 1990/91, 1995, 2000, 2005, and 2010 (n = 6, 862). Tumor characteristics...

  7. Study on potential antitumor mechanism of a novel Schiff base copper(II) complex: synthesis, crystal structure, DNA binding, cytotoxicity and apoptosis induction activity.

    Science.gov (United States)

    Qiao, Xin; Ma, Zhong-Ying; Xie, Cheng-Zhi; Xue, Fei; Zhang, Yan-Wen; Xu, Jing-Yuan; Qiang, Zhao-Yan; Lou, Jian-Shi; Chen, Gong-Jun; Yan, Shi-Ping

    2011-05-01

    A new cytotoxic copper(II) complex with Schiff base ligand [Cu(II)(5-Cl-pap)(OAc)(H(2)O)]·2H(2)O (1) (5-Cl-pap=N-2-pyridiylmethylidene-2-hydroxy-5-chloro-phenylamine), was synthesized and structurally characterized by X-ray diffraction. Single-crystal analysis revealed that the copper atom shows a 4+1 pyramidal coordination, a water oxygen appears in the apical position, and three of the basal positions are occupied by the NNO tridentate ligand and the fourth by an acetate oxygen. The interaction of Schiff base copper(II) complex 1 with DNA was investigated by UV-visible spectra, fluorescence spectra and agarose gel electrophoresis. The apparent binding constant (K(app)) value of 6.40×10(5) M(-1) for 1 with DNA suggests moderate intercalative binding mode. This copper(II) complex displayed efficient oxidative cleavage of supercoiled DNA, which might indicate that the underlying mechanism involve hydroxyl radical, singlet oxygen-like species, and hydrogen peroxide as reactive oxygen species. In addition, our present work showed the antitumor effect of 1 on cell cycle and apoptosis. Flow cytometric analysis revealed that HeLa cells were arrested in the S phase after treatment with 1. Fluorescence microscopic observation indicated that complex 1 can induce apoptosis of HeLa cells, whose process was mediated by intrinsic mitochondrial apoptotic pathway owing to the activation of caspase-9 and caspase-3. Copyright © 2011 Elsevier Inc. All rights reserved.

  8. Copper(II)-Mediated Hydrogen Sulfide and Thiol Oxidation to Disulfides and Organic Polysulfanes and Their Reductive Cleavage in Wine: Mechanistic Elucidation and Potential Applications.

    Science.gov (United States)

    Kreitman, Gal Y; Danilewicz, John C; Jeffery, David W; Elias, Ryan J

    2017-03-29

    Fermentation-derived volatile sulfur compounds (VSCs) are undesirable in wine and are often remediated in a process known as copper fining. In the present study, the addition of Cu(II) to model and real wine systems containing hydrogen sulfide (H 2 S) and thiols provided evidence for the generation of disulfides (disulfanes) and organic polysulfanes. Cu(II) fining of a white wine spiked with glutathione, H 2 S, and methanethiol (MeSH) resulted in the generation of MeSH-glutathione disulfide and trisulfane. In the present study, the mechanisms underlying the interaction of H 2 S and thiols with Cu(II) is discussed, and a prospective diagnostic test for releasing volatile sulfur compounds from their nonvolatile forms in wine is investigated. This test utilized a combination of reducing agents, metal chelators, and low-oxygen conditions to promote the release of H 2 S and MeSH, at levels above their reported sensory thresholds, from red and white wines that were otherwise free of sulfidic off-odors at the time of addition.

  9. Potential function of added minerals as nucleation sites and effect of humic substances on mineral formation by the nitrate-reducing Fe(II)-oxidizer Acidovorax sp. BoFeN1.

    Science.gov (United States)

    Dippon, Urs; Pantke, Claudia; Porsch, Katharina; Larese-Casanova, Phil; Kappler, Andreas

    2012-06-19

    The mobility of toxic metals and the transformation of organic pollutants in the environment are influenced and in many cases even controlled by iron minerals. Therefore knowing the factors influencing iron mineral formation and transformation by Fe(II)-oxidizing and Fe(III)-reducing bacteria is crucial for understanding the fate of contaminants and for the development of remediation technologies. In this study we followed mineral formation by the nitrate-reducing Fe(II)-oxidizing strain Acidovorax sp. BoFeN1 in the presence of the crystalline Fe(III) (oxyhydr)oxides goethite, magnetite and hematite added as potential nucleation sites. Mössbauer spectroscopy analysis of minerals precipitated by BoFeN1 in (57)Fe(II)-spiked microbial growth medium showed that goethite was formed in the absence of mineral additions as well as in the presence of goethite or hematite. The presence of magnetite minerals during Fe(II) oxidation induced the formation of magnetite in addition to goethite, while the addition of humic substances along with magnetite also led to goethite but no magnetite. This study showed that mineral formation not only depends on the aqueous geochemical conditions but can also be affected by the presence of mineral nucleation sites that initiate precipitation of the same underlying mineral phases.

  10. Workshop on the role of enhancement of utilization of primary and secondary hydro potential in the context of environmental protection. Part II

    International Nuclear Information System (INIS)

    1997-01-01

    The publication has been set up as proceedings of the workshop on the role of enhancement of utilization of primary and secondary hydro potential in the context of environmental protection. The proceedings consist of the following chapters: (1) Use of a part and a secondary hydroenergetic potential of the Slovak Republic for electric energy production and its impact on the environment; (2) Economic problems of utilization of hydroenergetic potential of the Slovak Republic and possibilities for their solution; (3) Modernization of control systems of primary and secondary hydro energetic sources of electricity from the point of view of their fulfillment of important functions in operation of a power engineering system in the Slovak Republic; (4) The most important structures utilizing primary and secondary hydroenergetic potential for electric energy production; (5) Progressive technologies, modernization of hydro power projects aimed at rationalization in a use of hydroenergetic potential and environment protection; (6) Possibilities of further utilization of hydroenergetic potential of the Slovak Republic

  11. Potentiated virucidal activity of pomegranate rind extract (PRE and punicalagin against Herpes simplex virus (HSV when co-administered with zinc (II ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV.

    Directory of Open Access Journals (Sweden)

    David M J Houston

    Full Text Available There is a clinical need for new therapeutic products against Herpes simplex virus (HSV. The pomegranate, fruit of the tree Punica granatum L, has since ancient times been linked to activity against infection. This work probed the activity of pomegranate rind extract (PRE and co-administered zinc (II ions.PRE was used in conjunction with zinc (II salts to challenge HSV-1 and aciclovir-resistant HSV in terms of virucidal plaque assay reduction and antiviral activities in epithelial Vero host cells. Cytotoxicity was determined by the MTS assay using a commercial kit.Zinc sulphate, zinc citrate, zinc stearate and zinc gluconate demonstrated similar potentiated virucidal activity with PRE against HSV-1 by up to 4-fold. A generally parabolic relationship was observed when HSV-1 was challenged with PRE and varying concentrations of ZnSO4, with a maximum potentiation factor of 5.5. Punicalagin had 8-fold greater virucidal activity than an equivalent mass of PRE. However, antiviral data showed that punicalagin had significantly lower antiviral activity compared to the activity of PRE (EC50 = 0.56 μg mL-1 a value comparable to aciclovir (EC50 = 0.18 μg mL-1; however, PRE also demonstrated potency against aciclovir-resistant HSV (EC50 = 0.02 μg mL-1, whereas aciclovir showed no activity. Antiviral action of PRE was not influenced by ZnSO4. No cytotoxicity was detected with any test solution.The potentiated virucidal activity of PRE by coadministered zinc (II has potential as a multi-action novel topical therapeutic agent against HSV infections, such as coldsores.

  12. Mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase and carnitine palmitoyltransferase II as potential control sites for ketogenesis during mitochondrion and peroxisome proliferation.

    Science.gov (United States)

    Madsen, L; Garras, A; Asins, G; Serra, D; Hegardt, F G; Berge, R K

    1999-05-01

    3-Thia fatty acids are potent hypolipidemic fatty acid derivatives and mitochondrion and peroxisome proliferators. Administration of 3-thia fatty acids to rats was followed by significantly increased levels of plasma ketone bodies, whereas the levels of plasma non-esterified fatty acids decreased. The hepatic mRNA levels of fatty acid binding protein and formation of acid-soluble products, using both palmitoyl-CoA and palmitoyl-L-carnitine as substrates, were increased. Hepatic mitochondrial carnitine palmitoyltransferase (CPT) -II and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase activities, immunodetectable proteins, and mRNA levels increased in parallel. In contrast, the mitochondrial CPT-I mRNA levels were unchanged and CPT-I enzyme activity was slightly reduced in the liver. The CoA ester of the monocarboxylic 3-thia fatty acid, tetradecylthioacetic acid, which accumulates in the liver after administration, inhibited the CPT-I activity in vitro, but not that of CPT-II. Acetoacetyl-CoA thiolase and HMG-CoA lyase activities involved in ketogenesis were increased, whereas the citrate synthase activity was decreased. The present data suggest that 3-thia fatty acids increase both the transport of fatty acids into the mitochondria and the capacity of the beta-oxidation process. Under these conditions, the regulation of ketogenesis may be shifted to step(s) beyond CPT-I. This opens the possibility that mitochondrial HMG-CoA synthase and CPT-II retain some control of ketone body formation.

  13. Apolipoprotein C-II Is a Potential Serum Biomarker as a Prognostic Factor of Locally Advanced Cervical Cancer After Chemoradiation Therapy

    International Nuclear Information System (INIS)

    Harima, Yoko; Ikeda, Koshi; Utsunomiya, Keita; Komemushi, Atsushi; Kanno, Shohei; Shiga, Toshiko; Tanigawa, Noboru

    2013-01-01

    Purpose: To determine pretreatment serum protein levels for generally applicable measurement to predict chemoradiation treatment outcomes in patients with locally advanced squamous cell cervical carcinoma (CC). Methods and Materials: In a screening study, measurements were conducted twice. At first, 6 serum samples from CC patients (3 with no evidence of disease [NED] and 3 with cancer-caused death [CD]) and 2 from healthy controls were tested. Next, 12 serum samples from different CC patients (8 NED, 4 CD) and 4 from healthy controls were examined. Subsequently, 28 different CC patients (18 NED, 10 CD) and 9 controls were analyzed in the validation study. Protein chips were treated with the sample sera, and the serum protein pattern was detected by surface-enhanced laser desorption and ionization–time-of-flight mass spectrometry (SELDI-TOF MS). Then, single MS-based peptide mass fingerprinting (PMF) and tandem MS (MS/MS)-based peptide/protein identification methods, were used to identify protein corresponding to the detected peak. And then, turbidimetric assay was used to measure the levels of a protein that indicated the best match with this peptide peak. Results: The same peak 8918 m/z was identified in both screening studies. Neither the screening study nor the validation study had significant differences in the appearance of this peak in the controls and NED. However, the intensity of the peak in CD was significantly lower than that of controls and NED in both pilot studies (P=.02, P=.04) and validation study (P=.01, P=.001). The protein indicated the best match with this peptide peak at 8918 m/z was identified as apolipoprotein C-II (ApoC-II) using PMF and MS/MS methods. Turbidimetric assay showed that the mean serum levels of ApoC-II tended to decrease in CD group when compared with NED group (P=.078). Conclusion: ApoC-II could be used as a biomarker for detection in predicting and estimating the radiation treatment outcome of patients with CC

  14. Apolipoprotein C-II Is a Potential Serum Biomarker as a Prognostic Factor of Locally Advanced Cervical Cancer After Chemoradiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Harima, Yoko, E-mail: harima@takii.kmu.ac.jp [Department of Radiology, Takii Hospital, Kansai Medical University, Moriguchi, Osaka (Japan); Ikeda, Koshi; Utsunomiya, Keita; Komemushi, Atsushi; Kanno, Shohei; Shiga, Toshiko [Department of Radiology, Takii Hospital, Kansai Medical University, Moriguchi, Osaka (Japan); Tanigawa, Noboru [Department of Radiology, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka (Japan)

    2013-12-01

    Purpose: To determine pretreatment serum protein levels for generally applicable measurement to predict chemoradiation treatment outcomes in patients with locally advanced squamous cell cervical carcinoma (CC). Methods and Materials: In a screening study, measurements were conducted twice. At first, 6 serum samples from CC patients (3 with no evidence of disease [NED] and 3 with cancer-caused death [CD]) and 2 from healthy controls were tested. Next, 12 serum samples from different CC patients (8 NED, 4 CD) and 4 from healthy controls were examined. Subsequently, 28 different CC patients (18 NED, 10 CD) and 9 controls were analyzed in the validation study. Protein chips were treated with the sample sera, and the serum protein pattern was detected by surface-enhanced laser desorption and ionization–time-of-flight mass spectrometry (SELDI-TOF MS). Then, single MS-based peptide mass fingerprinting (PMF) and tandem MS (MS/MS)-based peptide/protein identification methods, were used to identify protein corresponding to the detected peak. And then, turbidimetric assay was used to measure the levels of a protein that indicated the best match with this peptide peak. Results: The same peak 8918 m/z was identified in both screening studies. Neither the screening study nor the validation study had significant differences in the appearance of this peak in the controls and NED. However, the intensity of the peak in CD was significantly lower than that of controls and NED in both pilot studies (P=.02, P=.04) and validation study (P=.01, P=.001). The protein indicated the best match with this peptide peak at 8918 m/z was identified as apolipoprotein C-II (ApoC-II) using PMF and MS/MS methods. Turbidimetric assay showed that the mean serum levels of ApoC-II tended to decrease in CD group when compared with NED group (P=.078). Conclusion: ApoC-II could be used as a biomarker for detection in predicting and estimating the radiation treatment outcome of patients with CC.

  15. Characterization of Potential Antimicrobial Targets in Bacillus spp. II. Branched-Chain Aminotransferase and Methionine Regeneration in B. cereus and B. anthracis

    Science.gov (United States)

    2002-09-01

    canaline, un inhibiteur de transaminase, inhibait la croissance de B. cereus avec une C150 de 35 gM dans un milieu minimum et 760 pM dans un bouillon...Depuis quelques anndes, ii existe une croissance de la rdsistance naturelle du charbon A la pdnicilline et aux autres antibiotiques b~ta-lactamines...tabolisme du B. anthracis. L’inhibition de la croissance du B. cereus in vitro avec la transaminase inhibitrice de la canaline a montr6 que le compos6 a

  16. Pb II

    African Journals Online (AJOL)

    Windows User

    ., 2009) biomaterials. However, the ..... reported for various microorganisms by various researchers (Gong et al., 2005). At biomass ... the increase in initial Pb (II) was also observed for removal of Pb (II) by loofa sponge immobilized Aspergillus.

  17. (II) complexes

    African Journals Online (AJOL)

    activities of Schiff base tin (II) complexes. Neelofar1 ... Conclusion: All synthesized Schiff bases and their Tin (II) complexes showed high antimicrobial and ...... Singh HL. Synthesis and characterization of tin (II) complexes of fluorinated Schiff bases derived from amino acids. Spectrochim Acta Part A: Molec Biomolec.

  18. A comprehensive study on removal and recovery of copper(II) from aqueous solutions by NaOH-pretreated Marrubium globosum ssp. globosum leaves powder: potential for utilizing the copper(II) condensed desorption solutions in agricultural applications.

    Science.gov (United States)

    Kililç, Mehmet; Yazilcil, Hüseyin; Solak, Murat

    2009-04-01

    This paper reports on removal and recovery of copper(II) ions from aqueous solutions under batch experimental conditions using NaOH-pretreated powdered leaves of Marrubium globosum ssp. globosum plant. Experimental results showed that pH was optimized at the value of 5.5 by 16.23 mg/g. The increasing metal concentration and temperature caused an increase in biosorption capacity and the process reached its equilibrium in 60 min. The result obtained from kinetic and isotherm studies resulted in better agreement with pseudo second-order kinetic and Langmuir isotherm models. Thermodynamic parameters revealed that the Cu(2+) biosorption by the biomass was an endothermic process. The higher desorption efficiency above 90% was obtained in case of using Na(2)EDTA, K(4)O(7)P(2), HNO(3), HCl, and (NH(4))(2)C(2)O(4) x H(2)O solutions, individually. Reusability of the biomass was examined under consecutive biosorption-desorption cycles repeating five times. The most interesting finding of the study is the idea of utilizing the EDTA-Cu complex, which can be qualified as a residual from desorption processes, as a liquid chemical fertilizer in agricultural applications.

  19. The effect of potential on the high-temperature fatigue crack growth response of low alloy steels: Part II, electrochemical results

    International Nuclear Information System (INIS)

    Moshier, W.C.; James, L.A.

    1997-01-01

    Environmentally assisted cracking (EAC) in low alloy steels was found to be dependent on externally applied potential in low sulfur steels in high temperature water. EAC could be turned on when the specimen was polarized anodically above a critical potential. However, hydrogen (H) additions inhibited the ability of potential to affect EAC. The behavior was related to formation of H ions during H oxidation at the crack mouth. A mechanism based on formation of H sulfide at the crack tip and H ions at the crack mouth is presented to describe the process by which sulfides and H ions affect the critical sulfide concentration at the crack tip

  20. Sn(II) oxy-hydroxides as potential adsorbents for Cr(VI)-uptake from drinking water: An X-ray absorption study.

    Science.gov (United States)

    Pinakidou, Fani; Kaprara, Efthimia; Katsikini, Maria; Paloura, Eleni C; Simeonidis, Konstantinos; Mitrakas, Manassis

    2016-05-01

    The feasibility of implementing a Sn(II) oxy-hydroxide (Sn6O4(OH)4) for the reduction and adsorption of Cr(VI) in drinking water treatment was investigated using XAFS spectroscopies at the Cr-K-edge. The analysis of the Cr-K-edge XANES and EXAFS spectra verified the effective use of Sn6O4(OH)4 for successful Cr(VI) removal. Adsorption isotherms, as well as dynamic Rapid Small Scale Test (RSSCT) in NSF water matrix showed that Sn6O4(OH)4 can decrease Cr(VI) concentration below the upcoming regulation limit of 10μg/L for drinking water. Moreover, an uptake capacity of 7.2μg/mg at breakthrough concentration of 10μg/L was estimated from the RSSCT, while the residual Cr(VI) concentration ranged at sub-ppb level for a significant period of the experiment. Furthermore, no evidence for the formation of Cr(OH)3 precipitates was found. On the contrary, Cr(III)-oxyanions were chemisorbed onto SnO2, which was formed after Sn(II)-oxidation during Cr(VI)-reduction. Nevertheless, changes in the type of Cr(III)-inner sphere complexes were observed after increasing surface coverage: Cr(III)-oxyanions preferentially sorb in a geometry which combines both bidentate binuclear ((2)C) and monodentate ((1)V) geometries, at the expense of the present bidentate mononuclear ((2)E) contributions. On the other hand, the pH during sorption does not affect the adsorption mechanism of Cr(III)-species. The implementation of Sn6O4(OH)4 in water treatment technology combines the advantage of rapidly reducing a large amount of Cr(VI) due to donation of two electrons by Sn(II) and also the strong chemisorption of Cr(III) in a combination of the (2)C and (1)V configurations, which enhances the safe disposal of spent adsorbents. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Development of pyridine-containing macrocyclic copper(II) complexes: potential role in the redox modulation of oxaliplatin toxicity in human breast cells.

    Science.gov (United States)

    Fernandes, Ana S; Costa, Judite; Gaspar, Jorge; Rueff, José; Cabral, M Fátima; Cipriano, Madalena; Castro, Matilde; Oliveira, Nuno G

    2012-09-01

    The unique redox and catalytic chemistry of Cu has justified the development of novel Cu complexes for different therapeutic uses including cancer therapy. In this work, four pyridine-containing aza-macrocyclic copper(II) complexes were prepared (CuL1-CuL4) varying in ring size and/or substituents and their superoxide scavenging activity evaluated. CuL3, the most active superoxide scavenger, was further studied as a modulator of the cytotoxicity of oxaliplatin in epithelial breast MCF10A cells and in MCF7 breast cancer cells. Our results show that CuL3 enhances the therapeutic window of oxaliplatin, by both protecting non-tumour cells and increasing its cytotoxic effect in breast carcinoma cells. CuL3 is thus a promising complex to be further studied and to be used as a lead compound for the optimization of novel chemotherapy sensitizers.

  2. Exploring new potentials and generating hypothesis for management of locally advanced head neck cancer: Analysis of pooled data from two phase II trials

    Directory of Open Access Journals (Sweden)

    Chufal Kundan

    2010-01-01

    Full Text Available Background: To study the long term results of two phase II concurrent chemoradiotherapy protocols and conduct pooled data analysis with special emphasis on nodal density. Materials and Methods: In the period from April 2001 to May 2003, phase II Mitomycin C (MMC and late chemo-intensification (LCI protocols were started in the same institute, enrolling 69 and 74 patients respectively. Long term results for these individual trials are reported along with pooled data analysis. Results: Median follow-up time for whole group, MMC protocol and LCI protocol was 43.8 months (SD619.8, 55 months (SD 618.5 and 47.5 months (SD 620.9 respectively. LRFS, DFS and OS at five years for whole group was 59.4, 43.5 and 47.1% respectively, for MMC protocol was 59.9, 45.5 and 49.5% respectively and for LCI, protocol was 53.6%, 41.5% and 44.4% respectively. Subgroup analysis revealed that MMC protocol was more effective than LCI protocol in terms of DFS and OS in patients with hypo dense nodes while opposite was true for Isodense nodes. Multivariate analysis revealed nodal density as an independent variable that had an impact on treatment outcome. Risk of death in patients with hypo dense nodes was 2.91 times that of Isodense nodes. Conclusions: Innovative and pragmatic approach is required to address locally advanced head neck cancer. Long term results for MMC and LCI protocols are encouraging. Integrating the basic concepts of these protocols may help develop new protocols, which will facilitate the search for the optimal solution.

  3. Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms.

    Directory of Open Access Journals (Sweden)

    Belén Picatoste

    Full Text Available BACKGROUND: Myocardial fibrosis is a key process in diabetic cardiomyopathy. However, their underlying mechanisms have not been elucidated, leading to a lack of therapy. The glucagon-like peptide-1 (GLP-1 enhancer, sitagliptin, reduces hyperglycemia but may also trigger direct effects on the heart. METHODS: Goto-Kakizaki (GK rats developed type-II diabetes and received sitagliptin, an anti-hyperglycemic drug (metformin or vehicle (n=10, each. After cardiac structure and function assessment, plasma and left ventricles were isolated for biochemical studies. Cultured cardiomyocytes and fibroblasts were used for in vitro assays. RESULTS: Untreated GK rats exhibited hyperglycemia, hyperlipidemia, plasma GLP-1 decrease, and cardiac cell-death, hypertrophy, fibrosis and prolonged deceleration time. Moreover, cardiac pro-apoptotic/necrotic, hypertrophic and fibrotic factors were up-regulated. Importantly, both sitagliptin and metformin lessened all these parameters. In cultured cardiomyocytes and cardiac fibroblasts, high-concentration of palmitate or glucose induced cell-death, hypertrophy and fibrosis. Interestingly, GLP-1 and its insulinotropic-inactive metabolite, GLP-1(9-36, alleviated these responses. In addition, despite a specific GLP-1 receptor was only detected in cardiomyocytes, GLP-1 isoforms attenuated the pro-fibrotic expression in cardiomyocytes and fibroblasts. In addition, GLP-1 receptor signalling may be linked to PPARδ activation, and metformin may also exhibit anti-apoptotic/necrotic and anti-fibrotic direct effects in cardiac cells. CONCLUSIONS: Sitagliptin, via GLP-1 stabilization, promoted cardioprotection in type-II diabetic hearts primarily by limiting hyperglycemia e hyperlipidemia. However, GLP-1 and GLP-1(9-36 promoted survival and anti-hypertrophic/fibrotic effects on cultured cardiac cells, suggesting cell-autonomous cardioprotective actions.

  4. Potential of polyaniline modified clay nanocomposite as a selective decontamination adsorbent for Pb(II) ions from contaminated waters; kinetics and thermodynamic study.

    Science.gov (United States)

    Piri, Somayeh; Zanjani, Zahra Alikhani; Piri, Farideh; Zamani, Abbasali; Yaftian, Mohamadreza; Davari, Mehdi

    2016-01-01

    Nowadays significant attention is to nanocomposite compounds in water cleaning. In this article the synthesis and characterization of conductive polyaniline/clay (PANI/clay) as a hybrid nanocomposite with extended chain conformation and its application for water purification are presented. Clay samples were obtained from the central plain of Abhar region, Abhar, Zanjan Province, Iran. Clay was dried and sieved before used as adsorbent. The conductive polyaniline was inflicted into the layers of clay to fabricate a hybrid material. The structural properties of the fabricated nanocomposite are studied by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM). The elimination process of Pb(II) and Cd(II) ions from synthetics aqueous phase on the surface of PANI/clay as adsorbent were evaluated in batch experiments. Flame atomic absorption instrument spectrophotometer was used for determination of the studied ions concentration. Consequence change of the pH and initial metal amount in aqueous solution, the procedure time and the used adsorbent dose as the effective parameters on the removal efficiency was investigated. Surface characterization was exhibited that the clay layers were flaked in the hybrid nanocomposite. The results show that what happen when a nanocomposite polyaniline chain is inserted between the clay layers. The adsorption of ions confirmed a pH dependency procedure and a maximum removal value was seen at pH 5.0. The adsorption isotherm and the kinetics of the adsorption processes were described by Temkin model and pseudo-second-order equation. Time of procedure, pH and initial ion amount have a severe effect on adsorption efficiency of PANI/clay. By using suggested synthesise method, nano-composite as the adsorbent simply will be prepared. The prepared PANI/clay showed excellent adsorption capability for decontamination of Pb ions from contaminated water. Both of suggested synthesise and

  5. Kindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. II. Effects of the NMDA antagonist MK-801.

    LENUS (Irish Health Repository)

    Robinson, G B

    1991-10-18

    The effect of the non-competitive N-methyl-D-aspartate antagonist MK-801 on the early development of kindling-induced potentiation was examined in the rabbit hippocampal dentate gyrus. MK-801 (0.5 mg\\/kg) was administered 2 h before each daily kindling stimulation was applied to the perforant path. This treatment continued for the first 10 days of kindling. MK-801 depressed the growth of the afterdischarge duration and suppressed development of behavioral seizures. MK-801 did not block kindling-induced potentiation of either the perforant path-dentate granule cell population spike or excitatory postsynaptic potential. Random impulse train stimulation and non-linear systems analytic techniques were used to examine kindling-induced potentiation of presumed GABAergic recurrent inhibitory circuits. Both the magnitude and duration of kindling-induced response inhibition, to the second of each pair of impulses within the train, were reduced in rabbits pretreated with MK-801. These results suggest that MK-801 differentially affects kindling-induced potentiation of excitatory and inhibitory circuits within the rabbit hippocampal dentate gyrus.

  6. Screening the environmental fate of organic contaminants in sewage sludges applied to agricultural soils: II. The potential for transfers to plants and grazing animals.

    Science.gov (United States)

    Duarte-Davidson, R; Jones, K C

    1996-06-21

    This is the second of two papers which screen the environmental fate of sludge organic contaminants when applied to agricultural land. A simple screening model has been developed to assess the likelihood of organic contaminants accumulating into the food-chain following the application of sludge into arable and pasture land. The purpose of this exercise is to highlight those compounds that have the potential to accumulate into plants and animal tissues using data on physico-chemical properties of the compounds of interest. Over 300 organic compounds or groups of compounds which have been identified as potential pollutants in sludge have been screened for their potential to transfer from sludge-amended soils to plants via retention by root surfaces, root uptake and translocation, foliar uptake and animal intake via soil and herbage ingestion. Various organic contaminants have been identified as having a high potential to transfer into the food-chain through plant and animal accumulation. Two priority lists have been produced to include (a) those compounds which are shown as being of sufficient or suspected importance, but for which further sludge concentration data and fate studies would be necessary to check on their status, and (b) those compounds which have been highlighted in the screening processes as having a high potential to accumulate up the food-chain. This screening approach can be adapted to other chemicals as information on new chemicals and their physico-chemical properties becomes available.

  7. Comment on 'Spherical 2+p spin-glass model: An analytically solvable model with a glass-to-glass transition'

    International Nuclear Information System (INIS)

    Krakoviack, V.

    2007-01-01

    Guided by old results on simple mode-coupling models displaying glass-glass transitions, we demonstrate, through a crude analysis of the solution with one step of replica symmetry breaking (1RSB) derived by Crisanti and Leuzzi for the spherical s+p mean-field spin glass [Phys. Rev. B 73, 014412 (2006)], that the phase behavior of these systems is not yet fully understood when s and p are well separated. First, there seems to be a possibility of glass-glass transition scenarios in these systems. Second, we find clear indications that the 1RSB solution cannot be correct in the full glassy phase. Therefore, while the proposed analysis is clearly naive and probably inexact, it definitely calls for a reassessment of the physics of these systems, with the promise of potentially interesting developments in the theory of disordered and complex systems

  8. Sn(II) oxy-hydroxides as potential adsorbents for Cr(VI)-uptake from drinking water: An X-ray absorption study

    Energy Technology Data Exchange (ETDEWEB)

    Pinakidou, Fani; Kaprara, Efthimia [Aristotle University of Thessaloniki, School of Chemical Engineering, Analytical Chemistry Laboratory, 54124 Thessaloniki (Greece); Katsikini, Maria; Paloura, Eleni C.; Simeonidis, Konstantinos [Aristotle University of Thessaloniki, School of Physics, Department of Solid State Physics, 54124 Thessaloniki (Greece); Mitrakas, Manassis, E-mail: manasis@eng.auth.gr [Aristotle University of Thessaloniki, School of Chemical Engineering, Analytical Chemistry Laboratory, 54124 Thessaloniki (Greece)

    2016-05-01

    The feasibility of implementing a Sn(II) oxy-hydroxide (Sn{sub 6}O{sub 4}(OH){sub 4}) for the reduction and adsorption of Cr(VI) in drinking water treatment was investigated using XAFS spectroscopies at the Cr-K-edge. The analysis of the Cr-K-edge XANES and EXAFS spectra verified the effective use of Sn{sub 6}O{sub 4}(OH){sub 4} for successful Cr(VI) removal. Adsorption isotherms, as well as dynamic Rapid Small Scale Test (RSSCT) in NSF water matrix showed that Sn{sub 6}O{sub 4}(OH){sub 4} can decrease Cr(VI) concentration below the upcoming regulation limit of 10 μg/L for drinking water. Moreover, an uptake capacity of 7.2 μg/mg at breakthrough concentration of 10 μg/L was estimated from the RSSCT, while the residual Cr(VI) concentration ranged at sub-ppb level for a significant period of the experiment. Furthermore, no evidence for the formation of Cr(OH){sub 3} precipitates was found. On the contrary, Cr(III)-oxyanions were chemisorbed onto SnO{sub 2}, which was formed after Sn(II)-oxidation during Cr(VI)-reduction. Nevertheless, changes in the type of Cr(III)-inner sphere complexes were observed after increasing surface coverage: Cr(III)-oxyanions preferentially sorb in a geometry which combines both bidentate binuclear ({sup 2}C) and monodentate ({sup 1}V) geometries, at the expense of the present bidentate mononuclear ({sup 2}E) contributions. On the other hand, the pH during sorption does not affect the adsorption mechanism of Cr(III)-species. The implementation of Sn{sub 6}O{sub 4}(OH){sub 4} in water treatment technology combines the advantage of rapidly reducing a large amount of Cr(VI) due to donation of two electrons by Sn(II) and also the strong chemisorption of Cr(III) in a combination of the {sup 2}C and {sup 1}V configurations, which enhances the safe disposal of spent adsorbents. - Highlights: • Effective Cr(VI) removal from drinking water by Sn{sub 6}O{sub 4}(OH){sub 4} • Sn{sub 6}O{sub 4}(OH){sub 4} transformation to SnO{sub 2} after Cr

  9. Electrode processes at mercury in the far cathodic potential region II. The reduction of Li+ and mM Na+ from aqueous 1 M LiCl solution

    NARCIS (Netherlands)

    Reeves, R.M.; Sluyters-Rehbach, M.; Sluyters, J.H.

    The reduction of Li+ ions in 1 M concentration and the reduction of Na+ ions in mM concentration in aqueous solution, has been studied at the dropping mercury electrode, using d.c. polarography and electrode impedance measurements, as a function of frequency and electrode potential. The reduction of

  10. Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease.

    Science.gov (United States)

    Murphy, Caitlin C; Sanoff, Hanna K; Stitzenberg, Karyn B; Baron, John A; Lund, Jennifer L; Sandler, Robert S

    2017-01-01

    Background and Aims. As a first step toward understanding the increasing incidence of colorectal cancer (CRC) in younger (age stages II and III CRC. Methods. Patients were sampled from the National Cancer Institute's Patterns of Care studies in 1990/91, 1995, 2000, 2005, and 2010 ( n = 6, 862). Tumor characteristics and treatment data were obtained through medical record review and physician verification. We compared sociodemographic and clinicopathologic characteristics and treatment patterns of younger (age age 50-69, age ≥ 70) CRC patients. Results. Younger patients were more likely to be black (13%) and Hispanic (15%) than patients aged 50-69 years (11% and 10%, resp.) and ≥70 years (7% each). A larger proportion of young white (41%) and Hispanic (33%) patients had rectal tumors, whereas tumors in the right colon were the most common in young black patients (39%). The majority of younger patients received chemotherapy and radiation therapy, although receipt of microsatellite instability testing was suboptimal (27%). Conclusion. Characteristics of patients diagnosed with young-onset CRC differ considerably by race/ethnicity, with a higher proportion of black and Hispanic patients diagnosed at the age of < 50 years.

  11. Experimental and theoretical investigations on Pd(II) host-guest compound: Deciphering the structural and electronic features of a potential bioactive complex

    Science.gov (United States)

    Sreejith, S. S.; Mohan, Nithya; Prathapachandra Kurup, M. R.

    2017-10-01

    A Pd(II) complex from N,N‧-bis(2-hydroxy-3-ethoxybenzylidene)butane-1,4-diamine salen-type ligand has been synthesized and characterised using single crystal XRD analysis, elemental analysis, IR and UV-Vis spectroscopic methods. Thermal profile of the compound is investigated using TG-DTG-DSC method. The quantification of intermolecular interactions and surface morphology has been done using Hirshfeld surface study mapped using various functions like dnorm, shape index and curvedness. ESP analysis is done to visualize the electrophilic and nucleophilic regions in the complex. Geometry optimization of the structure is done using DFT at B3LYP/def2-TZVP level of theory. Frontier orbital analysis reveals the kinetical stability and chemical inertness of the complex. A detailed charge distribution analysis is done using different analytical methods like Mulliken, Löwdin, NPA and AIM methods. Further bond order analysis and topological analysis are also done. Finally the bioactivity of the titled complex is checked using molecular docking method on both DNA and protein.

  12. Potential use of California lignite and other alternate fuel for enhanced oil recovery. Phase I and II. Final report. [As alternative fuels for steam generation in thermal EOR

    Energy Technology Data Exchange (ETDEWEB)

    Shelton, R.; Shimizu, A.; Briggs, A.

    1980-02-01

    The Nation's continued reliance on liquid fossil fuels and decreasing reserves of light oils gives increased impetus to improving the recovery of heavy oil. Thermal enhanced oil recovery EOR techniques, such as steam injection, have generally been the most effective for increasing heavy oil production. However, conventional steam generation consumes a large fraction of the produced oil. The substitution of alternate (solid) fuels would release much of this consumed oil to market. This two-part report focuses on two solid fuels available in California, the site of most thermal EOR - petroleum coke and lignite. Phase I, entitled Economic Analysis, shows detailed cost comparisons between the two candidate fuels and also with Western coal. The analysis includes fuels characterizations, process designs for several combustion systems, and a thorough evaluation of the technical and economic uncertainties. In Phase II, many technical parameters of petroleum coke combustion were measured in a pilot-plant fluidized bed. The results of the study showed that petroleum coke combustion for EOR is feasible and cost effective in a fluidized bed combustor.

  13. Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease

    Directory of Open Access Journals (Sweden)

    Caitlin C. Murphy

    2017-01-01

    Full Text Available Background and Aims. As a first step toward understanding the increasing incidence of colorectal cancer (CRC in younger (age < 50 populations, we examined demographic, clinicopathologic, and socioeconomic characteristics and treatment receipt in a population-based sample of patients newly diagnosed with stages II and III CRC. Methods. Patients were sampled from the National Cancer Institute’s Patterns of Care studies in 1990/91, 1995, 2000, 2005, and 2010 (n=6,862. Tumor characteristics and treatment data were obtained through medical record review and physician verification. We compared sociodemographic and clinicopathologic characteristics and treatment patterns of younger (age < 50 and older (age 50–69, age ≥ 70 CRC patients. Results. Younger patients were more likely to be black (13% and Hispanic (15% than patients aged 50–69 years (11% and 10%, resp. and ≥70 years (7% each. A larger proportion of young white (41% and Hispanic (33% patients had rectal tumors, whereas tumors in the right colon were the most common in young black patients (39%. The majority of younger patients received chemotherapy and radiation therapy, although receipt of microsatellite instability testing was suboptimal (27%. Conclusion. Characteristics of patients diagnosed with young-onset CRC differ considerably by race/ethnicity, with a higher proportion of black and Hispanic patients diagnosed at the age of < 50 years.

  14. Identification of Potential MHC Class-II-Restricted Epitopes Derived from Leishmania donovani Antigens by Reverse Vaccinology and Evaluation of Their CD4+ T-Cell Responsiveness against Visceral Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Manas Ranjan Dikhit

    2017-12-01

    Full Text Available Visceral leishmaniasis (VL is one of the most neglected tropical diseases for which no vaccine exists. In spite of extensive efforts, no successful vaccine is available against this dreadful infectious disease. To support vaccine development, an immunoinformatics approach was applied to screen potential MHC class-II-restricted epitopes that can activate the immune cells. Initially, 37 epitopes derived from six stage-dependent, overexpressed antigens were predicted, which were presented by at least 26 diverse MHC class-II allele. Based on a population coverage analysis and human leukocyte antigen cross-presentation ability, six of the 37 epitopes were selected for further analysis. Stimulation with synthetic peptide alone or as a cocktail triggered intracellular IFN-γ production. Moreover, specific IgG antibodies were detected in the serum of active VL cases against P1, P4, P5, and P6 in order to evaluate the peptide effect on the humoral immune response. Additionally, most of the peptides, except P2, were found to be non-inducers of CD4+ IL-10 against both active VL as well as treated VL subjects. This finding suggests there is no role of these peptides in the pathogenesis of Leishmania. Peptide immunogenicity was validated in BALB/c mice immunized with a cocktail of synthetic peptide emulsified in complete Freund’s adjuvant/incomplete Freund’s adjuvant. The immunized splenocytes induced strong spleen cell proliferation upon parasite re-stimulation. Furthermore, increased IFN-γ, interleukin-12, IL-17, and IL-22 production augmented with elevated nitric oxide (NO synthesis is thought to play a crucial role in macrophage activation. In this investigation, we identified six MHC class-II-restricted epitope hotspots of Leishmania antigens that induce CD4+ Th1 and Th17 responses, which could be used to potentiate a human universal T-epitope vaccine against VL.

  15. The inviscid, compressible and rotational, 2D isotropic Burgers and pressureless Euler-Coriolis fluids: Solvable models with illustrations

    Science.gov (United States)

    Choquard, Ph.; Vuffray, M.

    2014-10-01

    The coupling between dilatation and vorticity, two coexisting and fundamental processes in fluid dynamics (Wu et al., 2006, pp. 3, 6) is investigated here, in the simplest cases of inviscid 2D isotropic Burgers and pressureless Euler-Coriolis fluids respectively modeled by single vortices confined in compressible, local, inertial and global, rotating, environments. The field equations are established, inductively, starting from the equations of the characteristics solved with an initial Helmholtz decomposition of the velocity fields namely a vorticity free and a divergence free part (Wu et al., 2006, Sects. 2.3.2, 2.3.3) and, deductively, by means of a canonical Hamiltonian Clebsch like formalism (Clebsch, 1857, 1859), implying two pairs of conjugate variables. Two vector valued fields are constants of the motion: the velocity field in the Burgers case and the momentum field per unit mass in the Euler-Coriolis one. Taking advantage of this property, a class of solutions for the mass densities of the fluids is given by the Jacobian of their sum with respect to the actual coordinates. Implementation of the isotropy hypothesis entails a radial dependence of the velocity potentials and of the stream functions associated to the compressible and to the rotational part of the fluids and results in the cancellation of the dilatation-rotational cross terms in the Jacobian. A simple expression is obtained for all the radially symmetric Jacobians occurring in the theory. Representative examples of regular and singular solutions are shown and the competition between dilatation and vorticity is illustrated. Inspired by thermodynamical, mean field theoretical analogies, a genuine variational formula is proposed which yields unique measure solutions for the radially symmetric fluid densities investigated. We stress that this variational formula, unlike the Hopf-Lax formula, enables us to treat systems which are both compressible and rotational. Moreover in the one

  16. Theoretical studies of H2--H2 collisions. II. Scattering and transport cross sections of hydrogen at low energies: Tests of a new ab initio vibrotor potential

    International Nuclear Information System (INIS)

    Close-coupled calculations of scattering amplitudes have been carried out for H 2 --H 2 collisions for a new ab initio potential energy surface, treating the hydrogen molecules as true vibrotors. The amplitudes were inserted into the kinetic theory expressions for integral and transport cross sections and used to compute (1) the elastic scattering of (j=0, v=0) para-hydrogen for relative velocities between 1000 and 2500 m/sec; (2) the viscosity differences of ortho- and para-hydrogen for temperatures less than 25 0 K; and (3) the thermal diffusion ratio of ortho- and para-hydrogen for temperatures between 50 and 150 0 K. The agreement with experiment is highly satisfactory and provides a thoroughgoing test of the new potential energy surface

  17. Potentials of the Heun class: The triconfluent case

    Energy Technology Data Exchange (ETDEWEB)

    Batic, D., E-mail: davide.batic@uwimona.edu.jm; Mills-Howell, D., E-mail: dominic.millz27@gmail.com [Department of Mathematics, University of the West Indies, Kingston 6 (Jamaica); Nowakowski, M., E-mail: mnowakos@uniandes.edu.co [Departamento de Fisica, Universidad de los Andes, Cra. 1E No. 18A-10, Bogota (Colombia)

    2015-05-15

    We study special classes of potentials for which the one-dimensional (or radial) Schrödinger equation can be reduced to a triconfluent Heun equation by a suitable coordinate transformation together with an additional transformation of the wave function. In particular, we analyze the behaviour of those subclasses of the potential arising when the ordinary differential equation governing the coordinate transformation admits explicit analytic solutions in terms of the radial variable. Furthermore, we obtain formulae for solutions of the eigenvalue problem of the associated radial Schrödinger operator. Last but not least, using methods of supersymmetric quantum mechanics we relate the considered potentials to a new class of exactly solvable ones.

  18. Studies on the mixed ligand complexes of copper(II involving a sulfa drug and some potentially bi or tridentate ligands under physiological conditions

    Directory of Open Access Journals (Sweden)

    S. Regupathy

    2014-12-01

    Full Text Available The stability constants of mixed ligand complexes formed in the Cu(II-sulfathiazole(stz(A-glycine(gly, dl-2-aminobutanoic acid(2aba, dl-3-aminobutanoic acid(3aba, 1,2-diaminopropane(dp, 1,3-diaminopropane(tp, dl-2,3-diaminopropanoic acid(dapa, dl-2,4-diaminobutanoic acid(daba, dl-2,5-diaminopentanoic acid(ornithine, orn(B systems have been determined pH-metrically at 37 °C and I = 0.15 mol dm−3 (NaClO4 using SCOGS program. Analysis of experimental data indicates the presence of CuABH, CuAB, CuAB2H2 or CuAB2 species. The Δlog K values demonstrate higher stabilities for the mixed ligand complexes compared to the binary analogues. The CuAB complexes with B = gly, 2aba, dapa & orn systems were isolated and characterized using micro analytical, magnetic moment, ESR, electrochemical studies, TG/DTA, power XRD and SEM analysis. Magnetic susceptibility and electronic spectral studies suggest square planar geometry for the CuAB complexes. The g values indicate that the unpaired electron lies in thedx2-y2 orbital. The TG/DTA studies reveal that the complexes are non hydrated and possesses high thermal stability. The powder XRD data suggest that the complex is microcrystalline. The antimicrobial activity and CT DNA cleavage studies of the complexes are also reported.

  19. In vitro evaluation of the cyto-genotoxic potential of Ruthenium(II) SCAR complexes: a promising class of antituberculosis agents.

    Science.gov (United States)

    De Grandis, Rone Aparecido; Resende, Flávia Aparecida; da Silva, Monize Martins; Pavan, Fernando Rogério; Batista, Alzir Azevedo; Varanda, Eliana Aparecida

    2016-03-01

    Tuberculosis is a top infectious disease killer worldwide, caused by the bacteria Mycobacterium tuberculosis. Increasing incidences of multiple drug-resistance (MDR) strains are emerging as one of the major public health threats. However, the drugs in use are still incapable of controlling the appalling upsurge of MDR. In recent years a marked number of research groups have devoted their attention toward the development of specific and cost-effective antimicrobial agents against targeted MDR-Tuberculosis. In previous studies, ruthenium(II) complexes (SCAR) have shown a promising activity against MDR-Tuberculosis although few studies have indeed considered ruthenium toxicity. Therefore, within the preclinical requirements, we have sought to determine the cyto-genotoxicity of three SCAR complexes in this present study. The treatment with the SCARs induced a concentration-dependent decrease in cell viability in CHO-K1 and HepG2 cells. Based on the clonogenic survival, SCAR 5 was found to be more cytotoxic while SCAR 6 exhibited selectivity action on tumor cells. Although SCAR 4 and 5 did not indicate any mutagenic activity as evidenced by the Ames and Cytokinesis block micronucleus cytome assays, the complex SCAR 6 was found to engender a frameshift mutation detected by Salmonella typhimurium in the presence of S9. Similarly, we observed a chromosomal damage in HepG2 cells with significant increases of micronuclei and nucleoplasmic bridges. These data indicate that SCAR 4 and 5 complexes did not show genotoxicity in our models while SCAR 6 was considered mutagenic. This study presented a comprehensive genotoxic evaluation of SCAR complexes were shown to be genotoxic in vitro. All in all, further studies are required to fully elucidate how the properties can affect human health. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Probabilistic theory of mean field games with applications II mean field games with common noise and master equations

    CERN Document Server

    Carmona, René

    2018-01-01

    This two-volume book offers a comprehensive treatment of the probabilistic approach to mean field game models and their applications. The book is self-contained in nature and includes original material and applications with explicit examples throughout, including numerical solutions. Volume II tackles the analysis of mean field games in which the players are affected by a common source of noise. The first part of the volume introduces and studies the concepts of weak and strong equilibria, and establishes general solvability results. The second part is devoted to the study of the master equation, a partial differential equation satisfied by the value function of the game over the space of probability measures. Existence of viscosity and classical solutions are proven and used to study asymptotics of games with finitely many players. Together, both Volume I and Volume II will greatly benefit mathematical graduate students and researchers interested in mean field games. The authors provide a detailed road map t...

  1. Copper (II)

    African Journals Online (AJOL)

    CLEMENT O BEWAJI

    ABSTRACT: A Schiff base was prepared from the reaction of 2 - amino - 3 – methylbutanoic acid and 2, 4 - pentanedione. The reaction of the prepared Schiff base with ethanolic solution of copper (II) chloride formed diaquo bis( N – 2 – amino – 3 - methylbutyl - 2, 4 - pentanedionato) copper (II) complex. The Schiff base is ...

  2. Nuclear Energy Center Site Survey, 1975. Part II. The U.S. electric power system and the potential role of nuclear energy centers

    International Nuclear Information System (INIS)

    1976-01-01

    Information related to Nuclear Energy Centers (NEC) in the U.S. is presented concerning the U.S. electric power system today; electricity demand history and forecasts; history and forecasts of the electric utility industry; regional notes; the status, history, and forecasts of the nuclear role; power plant siting problems and practices; nuclear facilities siting problems and practices; origin and evolution of the nuclear energy center concept; conceptualized description of nuclear energy centers; potential role of nuclear energy centers; assumptions, criteria, and bases; typical evolution of a nuclear energy center; and the nuclear fuel cycle

  3. Evaluation of the Medicinal Potential of Two Ruthenium(II) Polypyridine Complexes as One- and Two-Photon Photodynamic Therapy Photosensitizers.

    Science.gov (United States)

    Hess, Jeannine; Huang, Huaiyi; Kaiser, Adrian; Pierroz, Vanessa; Blacque, Olivier; Chao, Hui; Gasser, Gilles

    2017-07-21

    Two [Ru(phen) 2 dppz] 2+ derivatives (phen=1,10-phenantroline, dppz=dipyrido[3,2-a:2',3'-c]phenazine) with different functional groups on the dppz ligand [dppz-7,8-(OMe) 2 (1), dppz-7,8-(OH) 2 (2)] have been synthesized, characterized and investigated as photosensitizers (PSs) for photodynamic therapy (PDT) against cancer. Both complexes showed intense red phosphorescence and promising singlet oxygen ( 1 O 2 ) quantum yields of 75 % (1) and 54 % (2) in acetonitrile. Complex 1 (logP o/w =-0.52, 2.4 nmol Ru per mg protein) was found to be more lipophilic, having also a higher cellular uptake efficiency compared to 2 (logP o/w =-0.20, 0.9 nmol Ru per mg protein). Complex 1 localized evenly in HeLa cells whereas 2, was mainly visualized in the cell membrane by confocal microscopy. In the dark, complex 1 (IC 50 =36.5 μm) was found to be more toxic than complex 2 (IC 50 >100 μm) on a HeLa cells monolayer. Importantly, in view of PDT applications, both complexes were found to be non-toxic in the dark towards multicellular HeLa spheroids (IC 50 >100 μm). Upon one-photon irradiation (420 nm, 9.27 J cm -2 ), 1 exhibited higher phototoxicity (IC 50 =3.1 μm) than 2 (IC 50 =16.7 μm) on HeLa cell monolayers. When two-photon irradiation (800 nm, 9.90 J cm -2 ) was applied, only 1 (IC 50 =9.5 μm) was found to be active toward HeLa spheroids. This study demonstrates that the functional group on the intercalative ligand has a strong influence on the cellular localization and anticancer activity of Ru II polypyridyl complexes. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II-releasing polymer nanoparticles for potential use as a drug delivery vector

    Directory of Open Access Journals (Sweden)

    Harris Alesha

    2011-01-01

    Full Text Available Abstract The field of drug delivery focuses primarily on delivering small organic molecules or DNA/RNA as therapeutics and has largely ignored the potential for delivering catalytically active transition metal ions and complexes. The delivery of a variety of transition metals has potential for inducing apoptosis in targeted cells. The chief aims of this work were the development of a suitable delivery vector for a prototypical transition metal, Cu2+, and demonstration of the ability to impact cancer cell viability via exposure to such a Cu-loaded vector. Carboxylate-functionalized nanoparticles were synthesized by free radical polymerization and were subsequently loaded with Cu2+ via binding to particle-bound carboxylate functional groups. Cu loading and release were characterized via ICP MS, EDX, XPS, and elemental analysis. Results demonstrated that Cu could be loaded in high weight percent (up to 16 wt.% and that Cu was released from the particles in a pH-dependent manner. Metal release was a function of both pH and the presence of competing ligands. The toxicity of the particles was measured in HeLa cells where reductions in cell viability greater than 95% were observed at high Cu loading. The combined pH sensitivity and significant toxicity make this copper delivery vector an excellent candidate for the targeted killing of disease cells when combined with an effective cellular targeting strategy.

  5. Selective attention and the auditory vertex potential. I - Effects of stimulus delivery rate. II - Effects of signal intensity and masking noise

    Science.gov (United States)

    Schwent, V. L.; Hillyard, S. A.; Galambos, R.

    1976-01-01

    The effects of varying the rate of delivery of dichotic tone pip stimuli on selective attention measured by evoked-potential amplitudes and signal detectability scores were studied. The subjects attended to one channel (ear) of tones, ignored the other, and pressed a button whenever occasional targets - tones of a slightly higher pitch were detected in the attended ear. Under separate conditions, randomized interstimulus intervals were short, medium, and long. Another study compared the effects of attention on the N1 component of the auditory evoked potential for tone pips presented alone and when white noise was added to make the tones barely above detectability threshold in a three-channel listening task. Major conclusions are that (1) N1 is enlarged to stimuli in an attended channel only in the short interstimulus interval condition (averaging 350 msec), (2) N1 and P3 are related to different modes of selective attention, and (3) attention selectivity in multichannel listening task is greater when tones are faint and/or difficult to detect.

  6. Synthesis of Novel 1,4- Dihydropyridine Derivatives Bearing Biphenyl-2'-Tetrazole Substitution as Potential Dual Angiotensin II Receptors and Calcium Channel Blockers

    Directory of Open Access Journals (Sweden)

    Javid Shahbazi Mojarrad

    2011-06-01

    Full Text Available Introduction: We report the synthesis of novel 1,4-dihydropyridine derivatives containing biphenyl-2'-tetrazole moieties. We hypothesized that merging the key structural elements present in an AT1 receptor antagonist with key structural elements in 1,4-dihydropyridine calcium channel blockers would yield novel analogs with potential dual activity for both receptors. This strategy led to the design and synthesis of dialkyl 1,4-dihydro-2,6-dimethyl-4-[2-n-alkyl-1-[2΄-(1H-tetrazole-5-yl biphenyl -4-yl] methyl] imidazole-4(or 5-yl]- 3, 5-pyridinedicarboxylate analogs. Methods: These compounds were obtained by two methods starting from biphenyltetrazolyl-4-(or 5-imidazolecarboxaldehyde intermediates employing in classical Hantzsch condensation reaction. In the first method, triphenylmethyl protecting group of 4- or 5-carboxaldehyde intermediate was first removed in acidic media and then classical Hantzsch reaction was employed in order to obtain the final products. In the second method, without further deprotection process, protected 4- or 5-carboxaldehyde intermediate directly was used in Hantzsch reaction. Results: The second method was more efficient than the first method since the deprotection and ring closure reaction occurs simultaneously in one pot. Conclusion: Eight novel dihydropridines analogs were synthesized using classic Hantzsch condensation reaction. Chemical structures of the compounds were characterized by 1H NMR, infrared and mass spectroscopy.

  7. Endogenous oscillations of electric potential difference in the cambial region of the pine stem. II. Possible involvement of the oscillations in xylogenesis

    Directory of Open Access Journals (Sweden)

    Wojciech Kurek

    2014-01-01

    Full Text Available Direct and indirect interrelations between xylogenic processes and the endogenous electric potential difference (PD oscillations generated in the cambial region of isolated tissue blocks from pine trunks were investigated. The frequency of transient PD changes varied during the season and displayed three minima which were concurrent with periods of initiation and termination of cambial activity and with the time of transition from early- to late-wood production. The oscillations were damped by TIBA - an inhibitor of polar auxin transport and stimulated by IAA, but only when the hormone was supplied to the apical end of the tissue block. This suggests that the polar transport of auxin may be involved in generation of the transient PD changes. Results of 2-channel recordings in one tissue block suggest that a part of the recorded oscillations (10-25 % exhibit coordination in space and time: a wave-like pattern along the trunk axis is created by PD changes. The pattern might be a physical carrier of information coordinating processes of growth and differentiation in distant parts of the tree.

  8. A study of cloud-generated radiative heating and its generation of available potential energy. I - Theoretical background. II - Results for a climatological zonal mean January

    Science.gov (United States)

    Stuhlmann, R.; Smith, G. L.

    1988-01-01

    The effect of radiative heating and cooling by clouds on the available potential energy (APE) is theoretically discussed. It is shown that the cloud radiative contribution to the generation of APE is determined by the net cloud radiative heating and the efficiency factor, which is a function of the temperature distribution of the atmosphere. Results are presented for low and middle cloud effects for three atmospheric layers. Cloud radiative heating is found to be a single function of cloud optical thickness for all classes designed in terms of cloud top heights and optical thickness. Low clouds at low latitudes destroy APE an midclouds generate APE. A concept is developed to relate the cloud radiative heating to cloud heights and optical depths. Cloud-generated radiative heating is computed for January zonal mean conditions for low and midclouds. For both cases, the strongest influence is found in the low troposphere, with marked differences in signs and magnitudes. At extratropical latitudes, both cloud classes generate net radiative cooling. In the tropics, the effect of low cloud changes from net cooling to the net heating as the optical thickness increases, and midclouds cause net heating. A mechanism is described whereby this dependence produces a strong positive feedback effect on the development of SST anomalies in the tropical oceans.

  9. Study of hydrogen-molecule guests in type II clathrate hydrates using a force-matched potential model parameterised from ab initio molecular dynamics

    Science.gov (United States)

    Burnham, Christian J.; Futera, Zdenek; English, Niall J.

    2018-03-01

    The force-matching method has been applied to parameterise an empirical potential model for water-water and water-hydrogen intermolecular interactions for use in clathrate-hydrate simulations containing hydrogen guest molecules. The underlying reference simulations constituted ab initio molecular dynamics (AIMD) of clathrate hydrates with various occupations of hydrogen-molecule guests. It is shown that the resultant model is able to reproduce AIMD-derived free-energy curves for the movement of a tagged hydrogen molecule between the water cages that make up the clathrate, thus giving us confidence in the model. Furthermore, with the aid of an umbrella-sampling algorithm, we calculate barrier heights for the force-matched model, yielding the free-energy barrier for a tagged molecule to move between cages. The barrier heights are reasonably large, being on the order of 30 kJ/mol, and are consistent with our previous studies with empirical models [C. J. Burnham and N. J. English, J. Phys. Chem. C 120, 16561 (2016) and C. J. Burnham et al., Phys. Chem. Chem. Phys. 19, 717 (2017)]. Our results are in opposition to the literature, which claims that this system may have very low barrier heights. We also compare results to that using the more ad hoc empirical model of Alavi et al. [J. Chem. Phys. 123, 024507 (2005)] and find that this model does very well when judged against the force-matched and ab initio simulation data.

  10. Solvable models of working memories

    Science.gov (United States)

    MéZard, M.; Nadal, J. P.; Toulouse, G.

    1987-11-01

    We consider a family of models, which generalizes the Hopfield model of neural networks, and can be solved likewise. This family contains palimpsestic schemes, which give memories that behave in a similar way as a working (short-term) memory. The replica method leads to a simple formalism that allows for a detailed comparison between various schemes, and the study of various effects, such as repetitive learning.

  11. Hungry Kids: The Solvable Crisis

    Science.gov (United States)

    Felling, Christy

    2013-01-01

    The numbers speak for themselves in terms of the crisis of hunger among kids in the United States: More than 16 million children--one in five--live in households that struggle to put food on the table. Nearly half of all food stamp recipients are children. But, argues Felling, the battle against childhood hunger can be won; the United States has…

  12. A Moisture-Stable 3D Microporous CoII -Metal-Organic Framework with Potential for Highly Selective CO2 Separation under Ambient Conditions.

    Science.gov (United States)

    Chand, Santanu; Pal, Arun; Das, Madhab C

    2018-02-13

    Selective adsorption and separation of CO 2 from flue gas and landfill gas mixtures have drawn great attention in industry. Porous MOF materials are promising alternatives to achieve such separations; however, the stability in the presence of moisture must be taken into consideration. Herein, we have constructed a microporous metal-organic framework (MOF) {[Co(OBA)(L) 0.5 ]⋅S} n (IITKGP-8), by employing a V-shaped organic linker with an azo-functionalized N,N' spacer forming a 3D network with mab topology and 1D rhombus-shaped channels along the crystallographic 'b' axis with a void volume of 34.2 %. The activated MOF reveals a moderate CO 2 uptake capacity of 55.4 and 26.5 cm 3  g -1 at 273 and 295 K/1 bar, respectively, whereas it takes up a significantly lower amount of CH 4 and N 2 under similar conditions and thus exhibits its potential for highly selective sorption of CO 2 with excellent IAST selectivity of CO 2 /N 2 (106 at 273 K and 43.7 at 295 K) and CO 2 /CH 4 (17.7 at 273 K and 17.1 at 295 K) under 1 bar. More importantly, this MOF exhibits excellent moisture stability as assessed through PXRD experiments coupled with surface area analysis. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Effects of added chelated trace minerals, organic selenium, yeast culture, direct-fed microbials, and Yucca schidigera extract in horses: II. Nutrient excretion and potential environmental impact.

    Science.gov (United States)

    Gordon, M E; Edwards, M S; Sweeney, C R; Jerina, M L

    2013-08-01

    The objective of this study was to test the hypothesis that an equine diet formulated with chelated trace minerals, organic selenium, yeast culture, direct-fed microbials (DFM) and Yucca schidigera extract would decrease excretion of nutrients that have potential for environmental impact. Horses were acclimated to 100% pelleted diets formulated with (ADD) and without (CTRL) the aforementioned additives. Chelated sources of Cu, Zn, Mn, and Co were included in the ADD diet at a 100% replacement rate of sulfate forms used in the CTRL diet. Additionally, the ADD diet included organic selenium yeast, DFM, and Yucca schidigera extract. Ten horses were fed the 2 experimental diets during two 42-d periods in a crossover design. Total fecal and urine collection occurred during the last 14 d of each period. Results indicate no significant differences between Cu, Zn, Mn, and Co concentrations excreted via urine (P > 0.05) due to dietary treatment. There was no difference between fecal Cu and Mn concentrations (P > 0.05) based on diet consumed. Mean fecal Zn and Co concentrations excreted by horses consuming ADD were greater than CTRL (P 0.05). In feces stockpiled to simulate a crude composting method, no differences (P > 0.05) due to diet were detected for particle size, temperature, moisture, OM, total N, P, phosphate, K, moisture, potash, or ammonia N (P > 0.05). Although no difference (P = 0.2737) in feces stockpile temperature due to diet was found, temperature differences over time were documented (P < 0.0001). In conclusion, the addition of certain chelated mineral sources, organic Se yeast, DFM, and Yucca schidigera extract did not decrease most nutrient concentrations excreted. Horses consuming organic selenium as part of the additive diet had lower fecal and urine Se concentrations, as well as greater fecal K concentrations.

  14. Down-Regulation of Renal Gluconeogenesis in Type II Diabetic Rats Following Roux-en-Y Gastric Bypass Surgery: A Potential Mechanism in Hypoglycemic Effect

    Directory of Open Access Journals (Sweden)

    Yi Wen

    2015-03-01

    Full Text Available Objective: This study was initiated to evaluate the effects of Roux-en-Y gastric bypass surgery on renal gluconeogenesis in type 2 diabetic rats and its relationship with hormonal parameters. Methods: Diabetic rats were induced by intraperitoneal injection of streptozotocin (STZ; 35 mg/kg combined with a high-fat diet. They were then randomly divided into three groups: diabetes model group (DM group, n = 8, sham Roux-en-Y gastric bypass group (SRYGB group, n = 8, and Roux-en-Y gastric bypass group (RYGB group, n = 14. Another 8 normal rats comprised the normal control group (NC group, n = 8. Body weight, glucose, serum lipid, insulin, glucagon-like peptide-1 (GLP-1, leptin, and adiponectin were measured pre- and postoperatively. Glucose-6-phosphatase (G6Pase, phosphoenolpyruvate carboxykinase (PEPCK, insulin receptor-α (IR-α, insulin receptor-β (IR-β, and glycogen synthase kinase 3 beta (Gsk3b were measured in renal cortex by using RT-PCR and Western immune-blot analyses on the 4th week after operation. Results: Following RYGB surgery, surgery-treated rats showed significantly improved oral glucose tolerance, dyslipidemia and insulin resistance as well as increased post-gavage insulin levels and serum circulating levels of GLP-1 and adiponectin. RT-PCR and Western immune-blot analyses showed PEPCK and G6Pase protein and mRNA to be significantly decreased in the renal cortex in the RYGB group (p Conclusion: Down-regulation of renal gluconeogenic enzymes might be a potential mechanism in hypoglycemia. An improved insulin signal pathway in the renal cortex and increased circulating adiponectin concentrations may contribute to the decline of renal gluconeogenesis following RYGB surgery.

  15. Electrostatic control by lipids upon the membrane-bound (Na+ + K+)-ATPase. II. The influence of surface potential upon the activating ion equilibria.

    Science.gov (United States)

    Ahrens, M L

    1983-07-13

    Electrostatic influences upon the enzymatic activity of the (Na+ + K+)-ATPase from ox brain (EC 3.6.1.3) have been studied. (1) The characteristics of the temperature dependence of the activity - the slopes and inflection temperature, Ti, of the Arrhenius plots - have been shown to depend on the total concentration, but not on the specific properties of added monovalent ions. (2) The enzymatic activity has been shown to be subject simultaneously to unspecific and specific influences of alkali-metal ions or NH+4. Ion-specific effects result from different binding constants of complexation between activating ions and enzyme. These stability constants are affected by the formation of an electrical double layer at the membrane surface. With increasing electrostatic screening, the complex formation is destabilized and, as a consequence, the enzymatic activity decreases. (3) This interaction between ion binding and surface electrostatics enables the enzyme to adapt its activity to the actual ionic conditions. This gives rise to a complex net dependence of the enzymatic activity upon the concentrations of activating ions. Such dependencies are analyzed, and an 'activity surface' has been constructed which represents the enzymatic activity as a function of simultaneously varying concentrations of sodium and potassium. The shape of this activity surface is determined by the relations between ion concentrations, surface potential and the resulting stability of the complexation between the activating ions and the enzyme. By means of three-dimensional representation it is demonstrated that the adaptability of the stability constants is of great importance with respect to the maintenance of the optimal ionic concentrations within the living cell. Therefore, by means of the surrounding membrane, the ATPase is provided with a quality, in addition to its substrate specificity and catalytic ability, which is necessary for its function as a transport enzyme.

  16. An estimation of impact of anthropogenic aerosols in atmosphere of Tirana on solar insolation. Part II: Modification of solar energy potential

    Energy Technology Data Exchange (ETDEWEB)

    Buzra, Urim, E-mail: rimibuzra@yahoo.com; Berberi, Pellumb; Mitrushi, Driada; Muda, Valbona [Department of Engineering Physics, FIMIF, PUT, Tirana (Albania); Halili, Daniela [Department of physics, FNS, AXHU, Elbasan (Albania); Berdufi, Irma [Institute of Nuclear Physics, INP, TU, Tirana (Albania)

    2016-03-25

    Change of irradiative properties of the atmosphere during clear days is an indicator, among others, of existence of atmospheric aerosols and can be used as an indicator for assessment both air pollution and local modifications of solar energy potentials. The main objective of this study is estimation of influence of anthropogenic aerosols on solar energy falling in a horizontal surface during a cloudless day. We have analyzed and quantified the effect of aerosols on reducing the amount of solar energy that falls on the horizontal ground surface in cloudless sky conditions, estimating temporal evolution, both in daily and hour scale, considering also, side effects caused by relative humidity of the air wind speed and geometric factor. As an indicator of concentration of aerosols in atmosphere, we agreed to use the attenuation of solar radiation after the last rainy day. All data were corrected by factors such as, variations of relative humidity, wind speed and daily change of incident angle of solar radiation. We studied the change of solar insolation in three sites with different traffic intensity, one in city of Shkodra and two in city of Tirana. Fifteen days after last rainy day, approximate time needed to achieve saturation, the insolation drops only 3.1% in the city of Shkodra, while in two sites in city of Tirana are 8.5 % and 18.4%. These data show that reduction of solar insolation is closely related with anthropogenic activity, mainly traffic around the site of the meteorological station. The day to day difference tends to decrease with increasing of number of days passed from the last rainy day, which is an evidence of a trend toward a dynamic equilibrium between decantation process of aerosols during the night and their generation during the day.

  17. Short-rotation forestry of birch, maple, poplar and willow in Flanders (Belgium) II. Energy production and CO2 emission reduction potential

    International Nuclear Information System (INIS)

    Walle, Inge van de; Camp, Nancy van; Casteele, Liesbet van de; Verheyen, Kris; Lemeur, Raoul

    2007-01-01

    Belgium, being an EU country, has committed itself to a 7.5% reduction of greenhouse gas emissions during the first commitment period of the Kyoto Protocol. Within this framework, the Flemish government aims at reaching a share of 6% of renewable electricity in the total electricity production by 2010. In this work, the biomass production of birch, maple, poplar and willow in a short-rotation forestry (SRF) plantation after a 4-year growth period served as the base to calculate the amount of (electrical) energy that could be produced by this type of bioenergy crop in Flanders. The maximum amount of electricity that could be provided by SRF biomass was estimated at 72.9 GWh e year -1 , which only accounts for 0.16% of the total electricity production in this region. Although the energy output was rather low, the bioenergy production process under consideration appeared to be more energy efficient than energy production processes based on fossil fuels. The high efficiency of birch compared to the other species was mainly due to the high calorific value of the birch wood. The maximum CO 2 emission reduction potential of SRF plantations in Flanders was estimated at only 0.09% of the total annual CO 2 emission. The most interesting application of SRF in Flanders seemed to be the establishment of small-scale plantations, linked to a local combined heat and power plant. These plantations could be established on marginal arable soils or on polluted sites, and they could be of importance in the densely populated area of Flanders because of other environmental benefits, among which their function as (temporary) habitat for many species

  18. Geology, hydrogeology, and potential of intrinsic bioremediation at the National Park Service Dockside II site and adjacent areas, Charleston, South Carolina, 1993-94

    Science.gov (United States)

    Campbell, B.G.; Petkewich, M.D.; Landmeyer, J.E.; Chapelle, F.H.

    1996-01-01

    -water-drainage archway located in the study area is a conduit for the overflow of seawater into the surficial aquifer during exceptionally high tides. The efficiency of intrinsic bioremediation to reduce contaminant migration in the upper surficial aquifer at the National Park Service site was assessed to determine if, and at what concentrations, contaminants are being transported to the Cooper River. This assessment required incorporating hydrologic, geochemical, microbiologic, and demographic information into a predictive solute-transport model to determine rates of contaminant transport to the Cooper River. The transport of toluene and naphthalene was modeled as a surrogate for the transport of aromatic and other hydrocarbon compounds at the study area. Laboratory estimates of the adsorption coefficients for sediments of the upper surficial aquifer suggest preferential adsorption of naphthalene over toluene. The adsorption coefficient of naphthalene is at least two orders of magnitude greater than that determined for toluene. Laboratory microbial-biodegradation experiments indicate that microorganisms present in the shallow aquifer have the potential to degrade toluene under anaerobic and aerobic conditions, and naphthalene primarily under aerobic conditions. Rates of microbial biodegradation are similar for both compounds under aerobic conditions. Flow-model calibration to the January 1994 water-table surface of the upper surficial aquifer was achieved by specifying appropriate hydrogeologic boundary conditions and using hydraulic conductivity values determined in the field. The brick-lined storm-water drainage archway located in the study area was modeled to account for ground-water discharge through this drain. An exploratory modeling approach was used to evaluate the range of possible solutions that approximate the transport of contaminants to the observed distributions. Approximate toluene solute-transport conditions for January 1994 were estimated using velocity dist

  19. Topoisomerase II and leukemia

    Science.gov (United States)

    Pendleton, MaryJean; Lindsey, R. Hunter; Felix, Carolyn A.; Grimwade, David; Osheroff, Neil

    2014-01-01

    Type II topoisomerases are essential enzymes that modulate DNA under- and overwinding, knotting, and tangling. Beyond their critical physiological functions, these enzymes are the targets for some of the most widely prescribed anticancer drugs (topoisomerase II poisons) in clinical use. Topoisomerase II poisons kill cells by increasing levels of covalent enzyme-cleaved DNA complexes that are normal reaction intermediates. Drugs such as etoposide, doxorubicin, and mitoxantrone are frontline therapies for a variety of solid tumors and hematological malignancies. Unfortunately, their use is also associated with the development of specific leukemias. Regimens that include etoposide or doxorubicin are linked to the occurrence of acute myeloid leukemias that feature rearrangements at chromosomal band 11q23. Similar rearrangements are seen in infant leukemias and are associated with gestational diets that are high in naturally occurring topoisomerase II–active compounds. Finally, regimens that include mitoxantrone and epirubicin are linked to acute promyelocytic leukemias that feature t(15;17) rearrangements. The first part of this article will focus on type II topoisomerases and describe the mechanism of enzyme and drug action. The second part will discuss how topoisomerase II poisons trigger chromosomal breaks that lead to leukemia and potential approaches for dissociating the actions of drugs from their leukemogenic potential. PMID:24495080

  20. Galaxy S II

    CERN Document Server

    Gralla, Preston

    2011-01-01

    Unlock the potential of Samsung's outstanding smartphone with this jargon-free guide from technology guru Preston Gralla. You'll quickly learn how to shoot high-res photos and HD video, keep your schedule, stay in touch, and enjoy your favorite media. Every page is packed with illustrations and valuable advice to help you get the most from the smartest phone in town. The important stuff you need to know: Get dialed in. Learn your way around the Galaxy S II's calling and texting features.Go online. Browse the Web, manage email, and download apps with Galaxy S II's 3G/4G network (or create you

  1. Synthesis, α-glucosidase inhibitory activity and in silico study of tris-indole hybrid scaffold with oxadiazole ring: As potential leads for the management of type-II diabetes mellitus.

    Science.gov (United States)

    Taha, Muhammad; Rahim, Fazal; Imran, Syahrul; Ismail, Nor Hadiani; Ullah, Hayat; Selvaraj, Manikandan; Javid, Muhammad Tariq; Salar, Uzma; Ali, Muhammad; Khan, Khalid Mohammed

    2017-10-01

    Discovery of α-glucosidase inhibitors has been actively pursued with the aim to develop therapeutics for the treatment of type-II diabetes mellitus and the other carbohydrate mediated disease. In continuation of our drug discovery research on potential antidiabetic agents, we synthesized novel tris-indole-oxadiazole hybrid analogs (1-21), structurally characterized by various spectroscopic techniques such as 1 H NMR, EI-MS, and 13 C NMR. Elemental analysis was found in agreement with the calculated values. All compounds were evaluated for α-glucosidase inhibiting potential and showed potent inhibitory activity in the range of IC 50 =2.00±0.01-292.40±3.16μM as compared to standard acarbose (IC 50 =895.09±2.04µM). The pharmacokinetic predictions of tris-indole series using descriptor properties showed that almost all compounds in this series indicate the drug aptness. Detailed binding mode analyses with docking simulation was also carried out which showed that the inhibitors can be stabilized by the formation of hydrogen bonds with catalytic residues and the establishment of hydrophobic contacts at the opposite side of the active site. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. A limit of the confluent Heun equation and the Schroedinger equation for an inverted potential and for an electric dipole

    International Nuclear Information System (INIS)

    El-Jaick, Lea Jaccoud; Figueiredo, Bartolomeu D.B.

    2009-01-01

    We reexamine and extend a group of solutions in series of Bessel functions for a limiting case of the confluent Heun equation and, then, apply such solutions to the one-dimensional Schroedinger equation with an inverted quasi-exactly solvable potential as well as to the angular equation for an electron in the field of a point electric dipole. For the first problem we find finite and infinite-series solutions which are convergent and bounded for any value of the independent variable. For the angular equation, we also find expansions in series of Jacobi polynomials. (author)

  3. A High Molar Extinction Coefficient Ru(II Complex Functionalized with cis-Dithiocyanato-bis-(9-anthracenyl-10-(2-methyl-2-butenoic acid-1,10-phenanthroline: Potential Sensitizer for Stable Dye-Sensitized Solar Cells

    Directory of Open Access Journals (Sweden)

    Adewale O. Adeloye

    2014-01-01

    Full Text Available New heteroleptic ruthenium(II complex was formulated as [Ru(L12(NCS2], where L1 = 9-anthracenyl-10-(2-methyl-2-butenoic acid-1,10-phenanthroline was synthesized and its photophysical properties were studied and compared to previously reported analogue complex containing no anthracene moiety [Ru(L22(NCS2], L2 = (2-methyl-2-butenoic acid-1,10-phenanthroline. The two complexes though exhibit very strong molar extinction coefficient values; however, [Ru(L12(NCS2] shows better characteristic broad and intense metal-to-ligand charge transfer (MLCT absorption band and higher molar absorptivity coefficient at (λmax=522 nm, ε=6.60×104 M−1 cm−1 than that of [Ru(L22(NCS2] complex, (λmax=446 nm, ε=4.82×104 M−1 cm−1. At room temperature, long wavelength emissions with strong intensity ratio centered at 660 nm were recorded for [Ru(L12(NCS2] complex with a bathochromic shift (λem=700 nm for [Ru(L22(NCS2] complex. It was shown that the luminescence wavelength characteristic of the complexes may be a function relating to the increasing length of π-conjugation and/or molecular weight. A preliminary cyclic voltammetry of [Ru(L12(NCS2] complex also exhibits good electroredox activity with oxidation potential of about 1.04 V, significantly better than other Ru(II polypyridine complexes containing bidentate ligands.

  4. ISLSCP II Potential Natural Vegetation Cover

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set was developed to describe the state of the global land cover in terms of 15 major vegetation types, plus water, before alteration by humans. It forms a...

  5. Complexification of three potential models – II

    Indian Academy of Sciences (India)

    Corresponding author. E-mail: debnathmeyur@yahoo.co.in. MS received 19 December 2007; ..... The authors are grateful to the referee for constructive suggestions. References. [1] C M Bender and S Boettcher, Phys. Rev. Lett. 80, 5243 (1998).

  6. ISLSCP II Potential Natural Vegetation Cover

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: This data set was developed to describe the state of the global land cover in terms of 15 major vegetation types, plus water, before alteration by humans....

  7. Copper (II)

    African Journals Online (AJOL)

    CLEMENT O BEWAJI

    Bhardwaj C. N., and Singh V. R., (1994), Synthesis and characterization of thallium (I) complexes of biologically active benzothiazolines, Indian Journal Chemistry 33(3): 423 - 425. Chakraborty H., Paul N., and Rahman M. L., (1994), Catalytic activities of Schiff bases aquo complexes of Cu (II) in the hydrolysis of amino acid ...

  8. Cu(II), Zn(II)

    African Journals Online (AJOL)

    stereochemistry has been suggested to Zn(II), Cd(II) and Hg(II) complexes. The thermal analysis data provided the kinetic parameters as order of decomposition reaction, activation energy and frequency factor. All theoretical calculations of the ligand and the Cu(II) and Zn(II) complexes were made using Gaussian 03 rev.

  9. Estimation of the chemical-induced eye injury using a Weight-of-Evidence (WoE) battery of 21 artificial neural network (ANN) c-QSAR models (QSAR-21): part II: corrosion potential.

    Science.gov (United States)

    Verma, Rajeshwar P; Matthews, Edwin J

    2015-03-01

    This is part II of an in silico investigation of chemical-induced eye injury that was conducted at FDA's CFSAN. Serious eye damage caused by chemical (eye corrosion) is assessed using the rabbit Draize test, and this endpoint is an essential part of hazard identification and labeling of industrial and consumer products to ensure occupational and consumer safety. There is an urgent need to develop an alternative to the Draize test because EU's 7th amendment to the Cosmetic Directive (EC, 2003; 76/768/EEC) and recast Regulation now bans animal testing on all cosmetic product ingredients and EU's REACH Program limits animal testing for chemicals in commerce. Although in silico methods have been reported for eye irritation (reversible damage), QSARs specific for eye corrosion (irreversible damage) have not been published. This report describes the development of 21 ANN c-QSAR models (QSAR-21) for assessing eye corrosion potential of chemicals using a large and diverse CFSAN data set of 504 chemicals, ADMET Predictor's three sensitivity analyses and ANNE classification functionalities with 20% test set selection from seven different methods. QSAR-21 models were internally and externally validated and exhibited high predictive performance: average statistics for the training, verification, and external test sets of these models were 96/96/94% sensitivity and 91/91/90% specificity. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. Solvent assisted formation of ruthenium(III) and ruthenium(II) hydrazone complexes in one-pot with potential in vitro cytotoxicity and enhanced LDH, NO and ROS release.

    Science.gov (United States)

    Jayanthi, Eswaran; Kalaiselvi, Sivalingam; Padma, Viswanatha Vijaya; Bhuvanesh, Nattamai S P; Dharmaraj, Nallasamy

    2016-01-28

    A set each of new bivalent and trivalent ruthenium complexes, [Ru(III)(HL)Cl2(EPh3)2] and [Ru(II)(L)(CO)(EPh3)2] (E = P (complexes and ) or As (complexes and )) were synthesised from the reactions of [Ru(III)Cl3(EPh3)3] with 2-hydroxynaphthaldehyde benzoic acid hydrazone (H2L) in methanol-chloroform and characterized by elemental analysis, spectral data and XRD study. A suitable mechanism to account for the formation of bivalent ruthenium carbonyl complexes from the corresponding trivalent precursors is provided by considering the role of added base in the reaction. Interaction of complexes with CT-DNA/bovine serum albumin was analysed with absorption and emission spectral titration studies. In vitro cytotoxic potential of the above ruthenium hydrazone complexes assayed against the A549 cell line revealed a significant growth inhibition. The test complexes added in IC50 concentration into the cell culture medium enhanced the release of lactate dehydrogenase, NO and reactive oxygen species in comparison with the control. Cell death induced by the complexes was studied using a propidium iodide staining assay and showed noticeable changes in the cell morphology which resembled apoptosis.

  11. Co(II), Ni(II) and Zn(II)

    Indian Academy of Sciences (India)

    Unknown

    161. Synthesis, characterisation and electrochemical behaviour of. Cu(II), Co(II), Ni(II) and Zn(II) complexes derived from acetylacetone and p-anisidine and their antimicrobial activity. N RAMAN*, V MUTHURAJ, S RAVICHANDRAN and. A KULANDAISAMY. Department of Chemistry, VHNSN College, Virudhunagar 626 001 ...

  12. Part I. Application of pulse polarography and pulse anodic stripping to the determination of selected heavy metals in natural waters. Part II. Application of controlled potential coulometric techniques to the determination of uranium

    International Nuclear Information System (INIS)

    Crosmun, S.T.

    1977-06-01

    The use of a thin mercury film wax-impregnated graphite electrode for the simultaneous determination of cadmium, lead and zinc in an acetate buffer by differential pulse anodic stripping voltammetry is described. Optimal instrumental parameters for maximum resolution and sensitivity for simultaneous analysis of these three elements in natural waters are discussed. The interference of copper with the determination of zinc is investigated in detail. An optimal mercury film thickness for this electrode is suggested. A method utilizing differential pulse polarography for the determination of chromium (VI) in natural water is described. Additions of 0.62 μg Cu(II) ml -1 and 0.55 μg Fe(III) ml -1 did not interfere with the determination of 0.050 μg Cr(VI) ml -1 . The natural water samples containing Cr(VI) were buffered to approximately pH 7 with 0.1 M ammonium acetate and 0.005 M ethylenediamine and analyzed. Natural water samples of chromium from 0.035 μg to 2.0 μg.ml -1 may be analyzed directly without further preparation. The detection limit is 0.010 μg.ml -1 . A novel, highly efficient cell with integral stirrer for controlled potential coulometry is described. This cell was used to demonstrate the feasibility of determining uranium (VI) by predictive coulometry. A PDP 8/I minicomputer was used to predict the coulometric endpoint with high accuracy within 2.5 minutes in a titration which normally takes about 10 minutes. This technique was shown to yield acceptable results even in the presence of an interfering phosphate matrix

  13. Different regulation of miR-29a-3p in glomeruli and tubules in an experimental model of angiotensin II-dependent hypertension: potential role in renal fibrosis.

    Science.gov (United States)

    Castoldi, Giovanna; di Gioia, Cira; Giollo, Fabrizio; Carletti, Raffaella; Bombardi, Camila; Antoniotti, Marco; Roma, Francesca; Zerbini, Gianpaolo; Stella, Andrea

    2016-03-01

    The aim of this study was to evaluate the role of the angiotensin II (Ang II) induced-differential miRNA expression in renal glomerular and tubulo-interstitial fibrosis in an experimental model of Ang II-dependent hypertension. To clarify this issue, Sprague Dawley rats were treated with Ang II (200 ng/kg per minute, n = 15) or physiological saline (n = 14) for 4 weeks. Systolic blood pressure and albuminuria were measured every 2 weeks. At the end of the experimental period, renal glomerular and tubulo-interstitial fibrosis was evaluated by histomorphometric analysis, after Sirius-Red and Masson's trichrome staining. Ang II increased systolic blood pressure (P renal tubules and up-regulated in glomeruli. Real-time polymerase chain reaction (PCR) experiments confirmed in Ang II-treated rats a down-regulation of miR-29a-3p in tubules (P renal tubules is different from the one exerted in the glomeruli and that miR-29a-3p targets MMP-2. These results suggest that the development of renal fibrosis at glomerular and tubulo-interstitial level depends on different molecular mechanisms. © 2016 John Wiley & Sons Australia, Ltd.

  14. High-spin level structure and Ground-state phase transition in the odd-mass 103-109Rh isotopes in the framework of exactly solvable sdg interacting boson-fermion model

    Science.gov (United States)

    Ghapanvari, M.; Ghorashi, A. H.; Ranjbar, Z.; Jafarizadeh, M. A.

    2018-03-01

    In this article, the negative-parity states in the odd-mass 103-109Rh isotopes in terms of the sd and sdg interacting-boson fermion models were studied. The transitional interacting boson-fermion model Hamiltonians in sd and sdg-IBFM versions based on affine SU (1 , 1) Lie Algebra were employed to describe the evolution from the spherical to deformed gamma unstable shapes along with the chain of Rh isotopes. In this method, sdg-IBFM Hamiltonian, which is a three level pairing Hamiltonian was determined easily via the exactly solvable method. Some observables of the shape phase transitions such as energy levels, the two neutron separation energies, signature splitting of the γ-vibrational band, the α-decay and double β--decay energies were calculated and examined for these isotopes. The present calculation correctly reproduces the spherical to gamma-soft phase transition in the Rh isotopes. Some comparisons were made with sd-IBFM.

  15. Physics II for dummies

    CERN Document Server

    Holzner, Steven

    2010-01-01

    A plain-English guide to advanced physics. Does just thinking about the laws of motion make your head spin? Does studying electricity short your circuits? Physics II For Dummies walks you through the essentials and gives you easy-to-understand and digestible guidance on this often intimidating course. Thanks to this book, you don?t have to be Einstein to understand physics. As you learn about mechanical waves and sound, forces and fields, electric potential and electric energy, and much more, you?ll appreciate the For Dummies law: The easier we make it, the faster you'll understand it!

  16. and ni(ii)

    African Journals Online (AJOL)

    userpc

    NI(II) COMPLEXES WITH SCHIFF BASE DERIVED FROM SULPHANILAMINE AND. SALICYLALDEHYDE. ⃰Siraj, I. T. and ... with nickel(II) and cobalt(II) chloride in 2:1 mole ratio yielded Ni(II) and Co(II) complexes respectively. The synthesized .... coordinated ligand (coordination number) was determined using the relation ...

  17. Synthesis and characterisation of Cu (II), Ni (II), Mn (II), Zn (II) and ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 113; Issue 3. Synthesis and characterisation of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) Schiff base complexes derived from o-phenylenediamine and acetoacetanilide. N Raman Y Pitchaikani Raja A Kulandaisamy. Inorganic Volume 113 Issue 3 June 2001 pp 183-189 ...

  18. Synthesis and Characterization of Multimetallic Fe(II) and Mn(II ...

    African Journals Online (AJOL)

    MBI

    Synthesis and Characterization of Multimetallic Fe(II) and Mn(II) Using. N4O3 Potentially Heptadentate Ligand. Mustapha, A. and Gani, S. M.. Department of Chemistry, Federal University Dutse, PMB 7156, Jigawa State. Email: abmustapha2004@yahoo.com. ABSTRACT. Potentially heptadentate (N4O3) tripodal Schiff-base ...

  19. Elizabeth II uus kunstigalerii

    Index Scriptorium Estoniae

    1999-01-01

    Tähistamaks oma troonile asumise 50. aastapäeva, avab Elizabeth II 6. II 2002 Buckinghami palees uue kunstigalerii, mis ehitatakse palee tiibhoonena. Arhitekt John Simpson. Elizabeth II kunstikogust

  20. Cu(II) AND Zn(II)

    African Journals Online (AJOL)

    Preferred Customer

    SYNTHESIS OF 2,2-DIMETHYL-4-PHENYL-[1,3]-DIOXOLANE USING ZEOLITE. ENCAPSULATED Co(II), Cu(II) AND Zn(II) COMPLEXES. B.P. Nethravathi1, K. Rama Krishna Reddy2 and K.N. Mahendra1*. 1Department of Chemistry, Bangalore University, Bangalore-560001, India. 2Department of Chemistry, Government ...

  1. Binding Selectivity of Methanobactin from Methylosinus trichosporium OB3b for Copper(I), Silver(I), Zinc(II), Nickel(II), Cobalt(II), Manganese(II), Lead(II), and Iron(II)

    Science.gov (United States)

    McCabe, Jacob W.; Vangala, Rajpal; Angel, Laurence A.

    2017-12-01

    Methanobactin (Mb) from Methylosinus trichosporium OB3b is a member of a class of metal binding peptides identified in methanotrophic bacteria. Mb will selectively bind and reduce Cu(II) to Cu(I), and is thought to mediate the acquisition of the copper cofactor for the enzyme methane monooxygenase. These copper chelating properties of Mb make it potentially useful as a chelating agent for treatment of diseases where copper plays a role including Wilson's disease, cancers, and neurodegenerative diseases. Utilizing traveling wave ion mobility-mass spectrometry (TWIMS), the competition for the Mb copper binding site from Ag(I), Pb(II), Co(II), Fe(II), Mn(II), Ni(II), and Zn(II) has been determined by a series of metal ion titrations, pH titrations, and metal ion displacement titrations. The TWIMS analyses allowed for the explicit identification and quantification of all the individual Mb species present during the titrations and measured their collision cross-sections and collision-induced dissociation patterns. The results showed Ag(I) and Ni(II) could irreversibly bind to Mb and not be effectively displaced by Cu(I), whereas Ag(I) could also partially displace Cu(I) from the Mb complex. At pH ≈ 6.5, the Mb binding selectivity follows the order Ag(I)≈Cu(I)>Ni(II)≈Zn(II)>Co(II)>>Mn(II)≈Pb(II)>Fe(II), and at pH 7.5 to 10.4 the order is Ag(I)>Cu(I)>Ni(II)>Co(II)>Zn(II)>Mn(II)≈Pb(II)>Fe(II). Breakdown curves of the disulfide reduced Cu(I) and Ag(I) complexes showed a correlation existed between their relative stability and their compact folded structure indicated by their CCS. Fluorescence spectroscopy, which allowed the determination of the binding constant, compared well with the TWIMS analyses, with the exception of the Ni(II) complex. [Figure not available: see fulltext.

  2. Grad II: An Impact Study.

    Science.gov (United States)

    Johnson, Richard P.; Mayberry, Maurice E.

    1981-01-01

    Evaluates the impact of an integrated computer program called GRAD II (Graduate Resume Accumulation and Distribution) which allows a direct communication link between job-seeking students and potential employers. Response was generally favorable although a better mix of employers was needed. (JAC)

  3. binuclear copper(II) complexes

    Indian Academy of Sciences (India)

    Administrator

    . ClO4·H2O of 'end-off' Mannich base ligands have been synthesized. Cyclic voltammetry of these complexes revealed that the reduction process involved two successive one- electron transfer steps at different potentials. CuIICuII → CuIICuI → ...

  4. Efficiency of Chitosan for the Removal of Pb (II, Fe (II and Cu (II Ions from Aqueous Solutions

    Directory of Open Access Journals (Sweden)

    Soheil Sobhanardakani

    2014-09-01

    Full Text Available Background: Heavy metals have been recognized as harmful environmental pollutant known to produce highly toxic effects on different organs and systems of both humans and animals. The aim of this paper is to evaluate the adsorption potential of chitosan for the removal of Pb(II, Fe(II and Cu(II ions from aqueous solutions. Methods: This study was conducted in laboratory scale. In this paper chitosan has been used as an adsorbent for the removal of Pb(II, Fe(II and Cu(II from aqueous solution. In batch tests, the effects of parameters like pH solution (1.0-8.0, initial metal concentrations (100-1000 mgL-1, contact time (5.0-150 min and adsorbent dose (1.0-7.0 g on the adsorption process were studied. Results: The results showed that the adsorption of Pb(II, Fe(II and Cu(II ions on chitosan strongly depends on pH. The experimental isothermal data were analyzed using the Langmuir and Freundlich equations and it was found that the removal process followed the Langmuir isotherm and maximum adsorption capacity for the adsorption of Pb(II, Fe(II and Cu(II ions by the chitosan were 55.5mg g−1, 71.4 mg g−1 and 59 mg g−1, respectively, under equilibrium conditions at 25±1 ºC. The adsorption process was found to be well described by the pseudo-second-order rate model. Conclusion: The obtained results showed that chitosan is a readily, available, economic adsorbent and was found suitable for removing Pb(II, Fe(II and Cu(II ions from aqueous solution.

  5. Reaction Dynamics of O((3)P) + Propyne: II. Primary Products, Branching Ratios, and Role of Intersystem Crossing from Ab Initio Coupled Triplet/Singlet Potential Energy Surfaces and Statistical Calculations.

    Science.gov (United States)

    Gimondi, Ilaria; Cavallotti, Carlo; Vanuzzo, Gianmarco; Balucani, Nadia; Casavecchia, Piergiorgio

    2016-07-14

    The mechanism of the O((3)P) + CH3CCH reaction was investigated using a combined experimental/theoretical approach. Experimentally the reaction dynamics was studied using crossed molecular beams (CMB) with mass-spectrometric detection and time-of-flight analysis at 9.2 kcal/mol collision energy. Theoretically master equation (ME) simulations were performed on a potential energy surface (PES) determined using high-level ab initio electronic structure calculations. In this paper (II) the theoretical results are described and compared with experiments, while in paper (I) are reported and discussed the results of the experimental study. The PES was investigated by determining structures and vibrational frequencies of wells and transition states at the CASPT2/aug-cc-pVTZ level using a minimal active space. Energies were then determined at the CASPT2 level increasing systematically the active space and at the CCSD(T) level extrapolating to the complete basis set limit. Two separate portions of the triplet PES were investigated, as O((3)P) can add either on the terminal or the central carbon of the unsaturated propyne bond. Minimum energy crossing points (MECPs) between the triplet and singlet PESs were searched at the CASPT2 level. The calculated spin-orbit coupling constants between the T1 and S0 electronic surfaces were ∼25 cm(-1) for both PESs. The portions of the singlet PES that can be accessed from the MECPs were investigated at the same level of theory. The system reactivity was predicted integrating stochastically the one-dimensional ME using Rice-Ramsperger-Kassel-Marcus theory to determine rate constants on the full T1/S0 PESs, accounting explicitly for intersystem crossing (ISC) using the Landau-Zener model. The computational results are compared both with the branching ratios (BRs) determined experimentally in the companion paper (I) and with those estimated in a recent kinetic study at 298 K. The ME results allow to interpret the main system reactivity: CH

  6. Synthesis and characterisation of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II ...

    Indian Academy of Sciences (India)

    Unknown

    Synthesis and characterisation of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) Schiff base complexes derived from o-phenylenediamine and acetoacetanilide. N RAMAN*, Y PITCHAIKANI RAJA and A KULANDAISAMY. Department of Chemistry, VHNSN College, Virudhunagar 626 001, India e-mail: ra_man@123india.com.

  7. Fe(II), Ni(II), Ru(II)

    Indian Academy of Sciences (India)

    Administrator

    Ru(II) and Os(II) complexes of modified phenanthroline ligands. C V SASTRI, D EASWARAMOORTHY #, ATHILAKSHMI #,. L GIRIBABU and B G MAIYA. School of Chemistry, University of Hyderabad, Hyderabad 500 046, India. #Present address: Crescent Engineering College, Vandalur, Chennai 600 048,. India.

  8. Equilibrium and kinetic studies of Cu (II), Cd (II), Pb (II) and Fe (II ...

    African Journals Online (AJOL)

    Langmuir isotherm and pseudo-second order models were used to analyse the equilibrium and kinetic experimental data respectively. Equilibrium experimental data of Cu (II), Cd (II), Pb (II) and Fe (II) adsorption onto cocoa pod fitted well to Langmuir model and the kinetic data also fitted well to the pseudo-second order ...

  9. Copper(II), cobalt(II) and nickel(II) complexes of lapachol: synthesis, DNA interaction, and cytotoxicity.

    Science.gov (United States)

    Tabrizi, Leila; Talaie, Faranak; Chiniforoshan, Hossein

    2017-11-01

    Three novel copper(II), cobalt(II), and nickel(II) complexes of lapachol (Lap) containing 110-phenanthroline (phen) ligand, [M(Lap) 2 (phen)] (M=Cu(II), 1, Co(II), 2, and Ni(II), 3), have been synthesized and characterized using, elemental analysis and spectroscopic studies. Their interactions with calf thymus DNA (CT DNA) were investigated using viscosity, thermal denaturation, circular dichorism, fluorescence quenching, and electronic absorption spectroscopy. The DNA cleavage abilities of 1-3 have been studied, where cleavage activity of copper complex 1 is more than the complexes 2 and 3. The in vitro cytotoxic potential of the complexes 1-3 against human cervical carcinoma (HeLa), human liver hepatocellular carcinoma (HepG-2), and human colorectal adenocarcinoma (HT-29) cells indicated their promising antitumor activity with quite low IC 50 values in the range of .15-2.41 μM, which are lower than those of cisplatin.

  10. Optimization of simultaneous electrochemical determination of Cd(II), Pb(II), Cu(II) and Hg(II) at carbon nanotube-modified graphite electrodes.

    Science.gov (United States)

    Pikna, L'ubomír; Heželová, Mária; Kováčová, Zuzana

    2015-01-01

    The health of the environment is worsening every day. Monitoring of potentially toxic elements and remediation of environmental pollution are necessary. Therefore, the research and development of simple, inexpensive, portable and effective sensors is important. Electrochemistry is a useful component of the field of environment monitoring. The present study focuses on evaluating and comparing three types of electrodes (PIGE, PIGE/MWCNT/HNO3 and PIGE/MWCNT/EDTA/HNO3) employed for the simultaneous electrochemical determination of four potentially toxic elements: Cd(II), Pb(II), Cu(II) and Hg(II). Cyclic voltammograms were measured in an acetate buffer. The LOD, LOQ, the standard and relative precisions of the method and a prediction intervals were calculated (according to the technical procedure DIN 32 645) for the three electrodes and for each measured element. The LOD for PIGE/CNT/HNO3 (the electrode with narrowest calculated prediction intervals) was 2.98 × 10(-7) mol L(-1) for Cd(II), 4.83 × 10(-7) mol L(-1) for Pb(II), 3.81 × 10(-7) mol L(-1) for Cu(II), 6.79 × 10(-7) mol L(-1) for Hg(II). One of the benefits of this study was the determination of the amount of Hg(II) in the mixture of other elements.

  11. Absorption dynamics and delay time in complex potentials

    Science.gov (United States)

    Villavicencio, Jorge; Romo, Roberto; Hernández-Maldonado, Alberto

    2018-05-01

    The dynamics of absorption is analyzed by using an exactly solvable model that deals with an analytical solution to Schrödinger’s equation for cutoff initial plane waves incident on a complex absorbing potential. A dynamical absorption coefficient which allows us to explore the dynamical loss of particles from the transient to the stationary regime is derived. We find that the absorption process is characterized by the emission of a series of damped periodic pulses in time domain, associated with damped Rabi-type oscillations with a characteristic frequency, ω = (E + ɛ)/ℏ, where E is the energy of the incident waves and ‑ɛ is energy of the quasidiscrete state of the system induced by the absorptive part of the Hamiltonian; the width γ of this resonance governs the amplitude of the pulses. The resemblance of the time-dependent absorption coefficient with a real decay process is discussed, in particular the transition from exponential to nonexponential regimes, a well-known feature of quantum decay. We have also analyzed the effect of the absorptive part of the potential on the dynamical delay time, which behaves differently from the one observed in attractive real delta potentials, exhibiting two regimes: time advance and time delay.

  12. A High Molar Extinction Coefficient Ru(II) Complex Functionalized with cis-Dithiocyanato-bis-(9-anthracenyl-10-(2-methyl-2-butenoic acid)-1,10-phenanthroline): Potential Sensitizer for Stable Dye-Sensitized Solar Cells

    OpenAIRE

    Adeloye, Adewale O.; Ajibade, Peter A.

    2014-01-01

    New heteroleptic ruthenium(II) complex was formulated as [Ru(L1)2(NCS)2], where L1 = 9-anthracenyl-10-(2-methyl-2-butenoic acid)-1,10-phenanthroline was synthesized and its photophysical properties were studied and compared to previously reported analogue complex containing no anthracene moiety [Ru(L2)2(NCS)2], L2 = (2-methyl-2-butenoic acid)-1,10-phenanthroline. The two complexes though exhibit very strong molar extinction coefficient values; however, [Ru(L1)2(NCS)2] shows better characteris...

  13. Potentiometric determination of stability constants of cyanoacetato complexes of cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and lead(II).

    Science.gov (United States)

    Matusinović, T; Filipović, I

    1981-03-01

    Stability constants of cyanoacetato complexes of cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and lead(II) were determined potentiometrically at 25.0 +/- 0.1 degrees and ionic strength 2M (sodium perchlorate). The stability constants were evaluated by a weighted least-squares method.

  14. Cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and dioxouranium(II) complexes of thiophene-2-aldehyde-4-phenyl-thiosemicarbazone

    International Nuclear Information System (INIS)

    Singh, Balwan; Misra, Harihar

    1986-01-01

    The present paper describes the synthesis and characterisation of thiophene-2-aldehyde-4-phenylthiosemicarbazone (TAPTSC) and its metal complexes with Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and UO(II). (author). 30 refs., 1 table

  15. Vehicle-based road dust emission measurement—Part II: Effect of precipitation, wintertime road sanding, and street sweepers on inferred PM 10 emission potentials from paved and unpaved roads

    Science.gov (United States)

    Kuhns, H.; Etyemezian, V.; Green, M.; Hendrickson, Karin; McGown, Michael; Barton, Kevin; Pitchford, Marc

    Testing Re-Entrained Kinetic Emissions from Roads (TRAKER) is a new technique to infer paved and unpaved road dust PM 10 emission potentials based on particulate matter (PM) measurements made onboard a moving vehicle. Light scattering instruments mounted in front and behind the vehicle's tires measure the differential particle concentration of dust suspended by the vehicle's tire in contact with the road surface. Through empirical regressions relating the differential concentration (i.e. TRAKER signal) with the vehicle speed and the downwind flux of PM 10 particles from the road, an equation is derived to infer the speed independent road dust emission potential from the measured TRAKER signal. Measurements from TRAKER offer a new perspective on the processes that affect road dust emissions. The system was used to investigate temporal changes in emission potentials from paved roads in both the winter and summer in the Treasure Valley in Southwest Idaho. During the 3-week wintertime sampling period, the residential road dust PM 10 emission potential decreased by ˜50%. Summertime PM 10 emission potentials were similar to those observed at the end of the winter sampling and showed no upward or downward trends. Wintertime unpaved road emissions increased consistently with the number of days since the last rainfall. Measurement of road dust emission potentials after road sanding on dry roads indicated a 75% increase in PM 10 emissions after 2.5 h. This effect was short lived and emission potentials returned to their pre-sanding levels within 8 h of the sand application. Street sweeping with mechanical and vacuum sweepers was found to offer no measurable reduction in PM 10 emission potentials. On several roads, the PM 10 emission potentials actually increased immediately after vacuum sweeping. Long term effects of street sweeping on road dust emissions were not evaluated as part of this study and may offer some overall reduction in PM emissions from paved roads.

  16. On the pseudo-norm in some PT-symmetric potentials

    International Nuclear Information System (INIS)

    Levai, G.

    2005-01-01

    Complete text of publication follows. PT-symmetric quantum mechanical systems possess non-hermitian Hamiltonian, still they have some characteristics similar to hermitian problems. The most notable of these is their discrete energy spectrum, which can be partly or completely real. These systems are invariant under the simultaneous action of the P space and T time inversion operations. Perhaps the simplest PT-symmetric Hamiltonian contains a one-dimensional Schroedinger operator with a complex potential satisfying the V*(-x) = V (x) relation. Another typical feature PT-symmetric systems have in common with hermitian problems is that their basis states form an orthogonal set provided that the inner product is redefined as (ψ φ)PT ≡ (ψ Pφ). However, the norm defined by this inner product, the pseudo-norm turned out to possess indefinite sign, and this raised the question of the probabilistic interpretation of PT-symmetric systems. This problem was later put into a more general context when it was found that PT symmetry is a special case of pseudo-hermiticity, and this explains most of the peculiar features of PT-symmetric systems. There have been several attempts to link PT-symmetric, and in general, pseudo- hermitian systems with equivalent hermitian ones, and the sign of the pseudo-norm was found to play an important role in this respect. It is thus essential to evaluate the pseudo- norm for various potentials, especially considering the fact that there are some inconsistencies in the available results. Numerical studies indicated that the sign of the pseudo-norm typically alternates according to the n principal quantum number as (-1) n , and this was later proven for a class of potentials that are written in a polynomial form of ix. However, some potentials of other type did not fit into this line: this was the case for the Scarf II potential, the most well-known exactly solvable PT-symmetric potential. In contrast with the other examples, this potential is

  17. Porous cellulosic adsorbent for the removal of Cd (II), Pb(II) and Cu(II) ions from aqueous media

    Science.gov (United States)

    Barsbay, Murat; Kavaklı, Pınar Akkaş; Tilki, Serhad; Kavaklı, Cengiz; Güven, Olgun

    2018-01-01

    The main objective of this work is to prepare a renewable cellulosic adsorbent by γ-initiated grafting of poly(glycidyl methacrylate) (PGMA) from cellulose substrate and subsequent modification of PGMA with chelating species, iminodiacetic acid (IDA), for Cd (II), Pb(II) and Cu(II) removal from aqueous media. Modification of PGMA grafted cellulose with IDA in aqueous solution under mild conditions has proceeded efficiently to yield a natural-based and effective porous adsorbent with well-defined properties as provided by the controlled polymerization technique, namely RAFT, applied during the radiation-induced graft copolymerization step and with sufficient degree of IDA immobilization as confirmed by XPS, FTIR, contact angle measurements and elemental analysis. In order to examine the Cd (II), Pb(II) and Cu(II) removing performance of the resulting adsorbent, batch experiments were carried out by ICP-MS. The adsorption capacities were determined as 53.4 mg Cd(II)/g polymer, 52.0 mg Pb(II)/g polymer and 69.6 mg Cu(II)/g polymer at initial feed concentration of 250 ppm, showing the promising potential of the natural-based adsorbent to steadily and efficiently chemisorb toxic metal ions.

  18. Dinuclear ruthenium(II) and/or osmium(II) complexes of bipyridyl ...

    Indian Academy of Sciences (India)

    Administrator

    Discipline of Silicates and Catalysis, Central Salt & Marine Chemicals. Research Institute, G.B. Marg, Bhavnagar 364 002, India. Supramolecular Ru(II) and Os(II) polypyridyl chemistry gained considerable interest due to their rich electrochemical and photophysical properties and potential use in a variety of energy/electron ...

  19. Angiotensin II in Refractory Septic Shock.

    Science.gov (United States)

    Antonucci, Elio; Gleeson, Patrick J; Annoni, Filippo; Agosta, Sara; Orlando, Sergio; Taccone, Fabio Silvio; Velissaris, Dimitrios; Scolletta, Sabino

    2017-05-01

    Refractory septic shock is defined as persistently low mean arterial blood pressure despite volume resuscitation and titrated vasopressors/inotropes in patients with a proven or suspected infection and concomitant organ dysfunction. Its management typically requires high doses of catecholamines, which can induce significant adverse effects such as ischemia and arrhythmias. Angiotensin II (Ang II), a key product of the renin-angiotensin-aldosterone system, is a vasopressor agent that could be used in conjunction with other vasopressors to stabilize critically ill patients during refractory septic shock, and reduce catecholamine requirements. However, very few clinical data are available to support Ang II administration in this setting. Here, we review the current literature on this topic to better understand the role of Ang II administration during refractory septic shock, differentiating experimental from clinical studies. We also consider the potential role of exogenous Ang II administration in specific organ dysfunction and possible pitfalls with Ang II in sepsis. Various issues remain unresolved and future studies should investigate important topics such as: the optimal dose and timing of Ang II administration, a comparison between Ang II and the other vasopressors (epinephrine; vasopressin), and Ang II effects on microcirculation.

  20. and Cu(II)

    African Journals Online (AJOL)

    MBI

    complexes. The stoichiometry of the complexes were determined using Job's continuous variation method and the value was found to be 1:2 metal to ligand ratio. Stability constants ... Cobalt(II), Copper(II), Nickel(II), Spectrophotometric, Stability constant, Thermodynamic .... coordination of the metal ions with the chelating.

  1. Equilibrium and Kinetic Studies of Cu (II), Cd (II), Pb (II) and Fe (II ...

    African Journals Online (AJOL)

    ADOWIE PERE

    Adsorption isotherm studies of Cd (II), Pb (II) and Zn (II) ions bioremediation from aqueous solution using unmodified and EDTA-modified maize cob. Eclectica Quimica. 32(1): 33-42. Igwe, JC; Abia, AA (2003). Maize cob and husk as adsorbents or removal of Cd, Pb, and Zn ions from waste water. The physical Sci. 2: 83-94.

  2. A general method for the derivation of the functional forms of the effective energy terms in coarse-grained energy functions of polymers. II. Backbone-local potentials of coarse-grained O1→4-bonded polyglucose chains.

    Science.gov (United States)

    Lubecka, Emilia A; Liwo, Adam

    2017-09-21

    Based on the theory of the construction of coarse-grained force fields for polymer chains described in our recent work [A. K. Sieradzan et al., J. Chem. Phys. 146, 124106 (2017)], in this work effective coarse-grained potentials, to be used in the SUGRES-1P model of polysaccharides that is being developed in our laboratory, have been determined for the O⋯O⋯O virtual-bond angles (θ) and for the dihedral angles for rotation about the O⋯O virtual bonds (γ) of 1 → 4-linked glucosyl polysaccharides, for all possible combinations of [α,β]-[d,l]-glucose. The potentials of mean force corresponding to the virtual-bond angles and the virtual-bond dihedral angles were calculated from the free-energy surfaces of [α,β]-[d,l]-glucose pairs, determined by umbrella-sampling molecular-dynamics simulations with the AMBER12 force field, or combinations of the surfaces of two pairs sharing the overlapping residue, respectively, by integrating the respective Boltzmann factor over the dihedral angles λ for the rotation of the sugar units about the O⋯O virtual bonds. Analytical expressions were subsequently fitted to the potentials of mean force. The virtual-bond-torsional potentials depend on both virtual-bond-dihedral angles and virtual-bond angles. The virtual-bond-angle potentials contain a single minimum at about θ=140 ° for all pairs except β-d-[α,β]-l-glucose, where the global minimum is shifted to θ=150 ° and a secondary minimum appears at θ=90 ° . The torsional potentials favor small negative γ angles for the α-d-glucose and extended negative angles γ for the β-d-glucose chains, as observed in the experimental structures of starch and cellulose, respectively. It was also demonstrated that the approximate expression derived based on Kubo's cluster-cumulant theory, whose coefficients depend on the identity of the disugar units comprising a trisugar unit that defines a torsional potential, fits simultaneously all torsional potentials very well

  3. Mineral potential for volcanogenic massive sulfide deposits in the Islamic Republic of Mauritania, (phase V, deliverable 77): Chapter L in Second projet de renforcement institutionnel du secteur minier de la République Islamique de Mauritanie (PRISM-II)

    Science.gov (United States)

    Taylor, Cliff D.; Giles, Stuart A.

    2015-01-01

    Potential for base- and precious-metal-bearing volcanogenic massive sulfide deposits (VMS) exists in Mauritania in the greenstone belts of the southwestern Rgueïbat Shield and in the allochthonous portions of the central and southern Mauritanides. Additional potential exists for VMS deposits within the Tiris Complex of the central Rgueïbat Shield. Volcanosedimentary successions of Paleoproterozoic rocks of the northeastern portion of the Rgueïbat Shield are also permissive for volcanogenic massive sulfide deposits. These types of mineral occurrences are common features of marine volcanosedimentary successions worldwide and can be of almost any age, although Proterozoic examples are less abundant.

  4. A general method for the derivation of the functional forms of the effective energy terms in coarse-grained energy functions of polymers. II. Backbone-local potentials of coarse-grained O 1 →4 -bonded polyglucose chains

    Science.gov (United States)

    Lubecka, Emilia A.; Liwo, Adam

    2017-09-01

    Based on the theory of the construction of coarse-grained force fields for polymer chains described in our recent work [A. K. Sieradzan et al., J. Chem. Phys. 146, 124106 (2017)], in this work effective coarse-grained potentials, to be used in the SUGRES-1P model of polysaccharides that is being developed in our laboratory, have been determined for the O ⋯O ⋯O virtual-bond angles (θ ) and for the dihedral angles for rotation about the O ⋯O virtual bonds (γ ) of 1 → 4 -linked glucosyl polysaccharides, for all possible combinations of [α ,β ]-[d,l]-glucose. The potentials of mean force corresponding to the virtual-bond angles and the virtual-bond dihedral angles were calculated from the free-energy surfaces of [α ,β ]-[d,l]-glucose pairs, determined by umbrella-sampling molecular-dynamics simulations with the AMBER12 force field, or combinations of the surfaces of two pairs sharing the overlapping residue, respectively, by integrating the respective Boltzmann factor over the dihedral angles λ for the rotation of the sugar units about the O ⋯O virtual bonds. Analytical expressions were subsequently fitted to the potentials of mean force. The virtual-bond-torsional potentials depend on both virtual-bond-dihedral angles and virtual-bond angles. The virtual-bond-angle potentials contain a single minimum at about θ =14 0° for all pairs except β -d-[α ,β ] -l-glucose, where the global minimum is shifted to θ =150° and a secondary minimum appears at θ =90°. The torsional potentials favor small negative γ angles for the α -d-glucose and extended negative angles γ for the β -d-glucose chains, as observed in the experimental structures of starch and cellulose, respectively. It was also demonstrated that the approximate expression derived based on Kubo's cluster-cumulant theory, whose coefficients depend on the identity of the disugar units comprising a trisugar unit that defines a torsional potential, fits simultaneously all

  5. Unusual route for preparation of manganese(II), cobalt(II), zinc(II ...

    Indian Academy of Sciences (India)

    Administrator

    4H2O, zinc(II) carbonate,. ZnCO3 and cadmium(II) ... describing the preparation of manganese(II), cobalt(II), zinc(II) and cadmium(II) carbonate compounds are discussed. .... At room temperature the coordination compounds of manganese(II) ion ...

  6. Plasmas: Diversity, pervasiveness and potential

    Energy Technology Data Exchange (ETDEWEB)

    Eastman, Timothy E.

    1998-01-01

    When considered inclusively, plasma science and technology encompass immense diversity, pervasiveness and potential: diversity through numerous topical areas (see list of nearly 200 in Table II); pervasiveness with examples covering the full range of energy, time and spatial scale; and potential through innumerable current and future applications.

  7. Weak interactions modulating the dimensionality in supramolecular architectures in three new nickel(II)-hydrazone complexes, magnetostructural correlation, and catalytic potential for epoxidation of alkenes under phase transfer conditions.

    Science.gov (United States)

    Sadhukhan, Dipali; Ray, Aurkie; Pilet, Guillaume; Rizzoli, Corrado; Rosair, Georgina M; Gómez-García, Carlos J; Signorella, Sandra; Bellú, Sebastián; Mitra, Samiran

    2011-09-05

    Three different ONO donor acetyl hydrazone Schiff bases have been synthesized from the condensation of acetic hydrazide with three different carbonyl compounds: salicylaldehyde (HL(1)), 2-hydroxyacetophenone (HL(2)), and 2, 3-dihydroxybenzaldehyde (HL(3)). These tridentate ligands are reacted with Ni(OOCCF(3))(2)·xH(2)O to yield three new Ni(II) complexes having distorted octahedral geometry at each Ni center: [Ni(L(1))(OOCCF(3))(CH(3)OH)](2) (1), [Ni(L(2))(OOCCF(3))(H(2)O)](2) (2), and [Ni(L(3))(L(3)H)](OOCCF(3))(H(2)O)(1.65)(CH(3)OH)(0.35) (3). The ligands and the complexes have been characterized by elemental analysis and IR and UV-vis spectroscopy, and the structures of the complexes have been established by single crystal X-ray diffraction (XRD) study. 1 and 2 are centrosymmetric dinuclear complexes and are structural isomers whereas 3 is a bis chelated cationic monomer coordinated by one neutral and one monoanionic ligand. O-H···O hydrogen bonds in 3 lead to the formation of a dimer. Slight steric and electronic modifications in the ligand backbone provoke differences in the supramolecular architectures of the complexes, leading to a variety of one, two, and three-dimensional hydrogen bonded networks in complexes 1-3 respectively. Variable temperature magnetic susceptibility measurements reveal that moderate antiferromagnetic interactions operate between phenoxo bridged Ni(II) dimers in 1 and 2 whereas very weak antiferromagnetic exchange occurs through hydrogen bonding and π-π stacking interactions in 3. All complexes are proved to be efficient catalysts for the epoxidation of alkenes by NaOCl under phase transfer condition. The efficiency of alkene epoxidation is dramatically enhanced by lowering the pH, and the reactions are supposed to involve high valent Ni(III)-OCl or Ni(III)-O· intermediates. 3 is the best epoxidation catalyst among the three complexes with 99% conversion and very high turnover number (TON, 396).

  8. Finite Groups with Given Quantitative Non-Nilpotent Subgroups II

    DEFF Research Database (Denmark)

    Shi, Jiangtao; Zhang, Cui

    2014-01-01

    As an extension of Shi and Zhang's 2011 article [4], we prove that any finite group having at most 23 non-normal non-nilpotent proper subgroups is solvable except for G ≅ A 5 or SL(2, 5), and any finite group having at most three conjugacy classes of non-normal non-nilpotent proper subgroups...

  9. Reconstructing bidimensional scalar field theory models

    International Nuclear Information System (INIS)

    Flores, Gabriel H.; Svaiter, N.F.

    2001-07-01

    In this paper we review how to reconstruct scalar field theories in two dimensional spacetime starting from solvable Scrodinger equations. Theree different Schrodinger potentials are analyzed. We obtained two new models starting from the Morse and Scarf II hyperbolic potencials, the U (θ) θ 2 In 2 (θ 2 ) model and U (θ) = θ 2 cos 2 (In(θ 2 )) model respectively. (author)

  10. Selective Hg(II) adsorption from aqueous solutions of Hg(II) and Pb(II) by hydrolyzed acrylamide-grafted PET films.

    Science.gov (United States)

    Rahman, Nazia; Sato, Nobuhiro; Sugiyama, Masaaki; Hidaka, Yoshiki; Okabe, Hirotaka; Hara, Kazuhiro

    2014-01-01

    Selective Hg(II) adsorption from aqueous solutions of Hg(II) and Pb(II) using hydrolyzed acrylamide (AAm)-grafted polyethylene terephthalate (PET) films was examined to explore the potential reuse of waste PET materials. Selective recovery of Hg(II) from a mixture of soft acids with similar structure, such as Hg(II) and Pb(II), is important to allow the reuse of recovered Hg(II). An adsorbent for selective Hg(II) adsorption was prepared by γ-ray-induced grafting of AAm onto PET films followed by partial hydrolysis through KOH treatment. The adsorption capacity of the AAm-grafted PET films for Hg(II) ions increased from 15 to 70 mg/g after partial hydrolysis because of the reduction of hydrogen bonding between -CONH2 groups and the corresponding improved access of metal ions to the amide groups. The prepared adsorbent was characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. The absorbent film showed high selectivity for the adsorption of Hg(II) over Pb(II) throughout the entire initial metal concentration range (100-500 mg/L) and pH range (2.2-5.6) studied. The high selectivity is attributed to the ability of Hg(II) ions to form covalent bonds with the amide groups. The calculated selectivity coefficient for the adsorbent binding Hg(II) over Pb(II) was 19.2 at pH 4.5 with an initial metal concentration of 100 mg/L. Selective Hg(II) adsorption equilibrium data followed the Langmuir model and kinetic data were well fitted by a pseudo-second-order equation. The adsorbed Hg(II) and Pb(II) ions were effectively desorbed from the adsorbent film by acid treatment, and the regenerated film showed no marked loss of adsorption capacity upon reuse for selective Hg(II) adsorption.

  11. Complexes of cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and dioxouranium(II) with thiophene-2-aldehydethiosemicarbazone

    International Nuclear Information System (INIS)

    Singh, Balwan; Misra, Harihar

    1986-01-01

    Metal complexes of thiosemicarbazides have been known for their pharmacological applications. Significant antitubercular, fungicidal and antiviral activities have been reported for thiosemicarbazides and their derivatives. The present study describes the systhesis and characterisation of complexes of Co II , Cu II , Zn II ,Cd II and UO II with thiosemicarbazone obtained by condensing thiophene-2-aldehyde with thiosemicarbazide. 17 refs., 2 tables. (author)

  12. New classes of potentials for which the radial Schroedinger equation can be solved at zero energy

    International Nuclear Information System (INIS)

    Chadan, Khosrow; Kobayashi, Reido

    2006-01-01

    Given two spherically symmetric and short-range potentials V 0 and V 1 for which the radial Schroedinger equation can be solved explicitly at zero energy, we show how to construct a new potential V for which the radial equation can again be solved explicitly at zero energy. The new potential and its corresponding wavefunction are given explicitly in terms of V 0 and V 1 , and their corresponding wavefunctions ψ 0 and ψ 1 . V 0 must be such that it sustains no bound states (either repulsive, or attractive but weak). However, V 1 can sustain any (finite) number of bound states. The new potential V has the same number of bound states, by construction, but the corresponding (negative) energies are, of course, different. Once this is achieved, one can start then from V 0 and V, and construct a new potential V-bar for which the radial equation is again solvable explicitly. And the process can be repeated indefinitely. We exhibit first the construction, and the proof of its validity, for regular short-range potentials, i.e. those for which rV 0 (r) and rV 1 (r) are L 1 at the origin. It is then seen that the construction extends automatically to potentials which are singular at r = 0. It can also be extended to V 0 long range (Coulomb, etc). We finally give several explicit examples

  13. Exact eigenfunctions of the linear ramp potential in the Gross-Pitaevskii equation for the Bose-Einstein condensate

    DEFF Research Database (Denmark)

    Tuszynski, J. A.; Middleton, J.; Christiansen, Peter Leth

    2001-01-01

    Properties of magnetically trapped Bose gases are investigated within the Gross-Pitaevskii approximation for the condensate wavefunction. A linear ramp potential in the one-dimensional representation is shown to be exactly solvable. The wavefunction takes the form of the second Painleve...... transcendent and can be very accurately estimated using elementary functions which are globally non-singular. We analyse the physical characteristics of these condensate wavefunctions whose novel feature is a damped oscillatory profile. The nodeless solution, which corresponds to the lowest energy state....... agrees with its earlier estimate using a linear analysis, while the new damped oscillatory solutions reveal a spectrum of the condensate's excited, highly inhomogeneous excited states. (C) 2001 Elsevier Science B.V. All rights reserved....

  14. Nonlinear theory of scattering by localized potentials in metals

    Energy Technology Data Exchange (ETDEWEB)

    Howard, I A [Department of Physics, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp (Belgium); March, N H [Department of Physics, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp (Belgium); Oxford University, Oxford (United Kingdom); Echenique, P M [Donostia International Physics Center (DIPC), 20018 San Sebastian, Basque Country (Spain); Departamento de Fisica de Materiales and Centro Mixto CSIC-UPV/EHU, Facultad de Quimicas, UPV/EHU, Apartado 1072, 20080, San Sebastian (Spain)

    2003-11-14

    In early work, March and Murray gave a perturbation theory of the Dirac density matrix {gamma}(r, r') generated by a localized potential V(r) embedded in an initially uniform Fermi gas to all orders in V(r). For potentials sufficiently slowly varying in space, they summed the resulting series for r' = r to regain the Thomas-Fermi density {rho}(r) {proportional_to} [{mu} - V(r)]{sup 3/2}, with {mu} the chemical potential of the Fermi gas. For an admittedly simplistic repulsive central potential V(r) = vertical bar A vertical bar exp(-cr), it is first shown here that what amounts to the sum of the March-Murray series for the s-wave (only) contribution to the density, namely {rho}{sub s}(r, {mu}), can be obtained in closed form. Furthermore, for specific numerical values of A and c in this exponential potential, the long-range behaviour of {rho}{sub s}(r, {mu}) is related to the zero-potential form of March and Murray, which merely suffers a {mu}-dependent phase shift. This result is interpreted in relation to the recent high density screening theorem of Zaremba, Nagy and Echenique. A brief discussion of excess electrical resistivity caused by nonlinear scattering in a Fermi gas is added; this now involves an off-diagonal local density of states. Finally, for periodic lattices, contact is made with the quantum-mechanical defect centre models of Koster and Slater (1954 Phys. Rev. 96 1208) and of Beeby (1967 Proc. R. Soc. A 302 113), and also with the semiclassical approximation of Friedel (1954 Adv. Phys. 3 446). In appendices, solvable low-dimensional models are briefly summarized.

  15. Solvable relativistic quantum dots with vibrational spectra

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2005-01-01

    Roč. 55, č. 9 (2005), s. 1187 ISSN 0011-4626 R&D Projects: GA AV ČR IAA1048302 Institutional research plan: CEZ:AV0Z10480505 Keywords : Klein-Gordon equation * point interactions * PT symmetry Subject RIV: BE - Theoretical Physics Impact factor: 0.360, year: 2005

  16. Exactly solvable cellular automaton traffic jam model.

    Science.gov (United States)

    Kearney, Michael J

    2006-12-01

    A detailed study is undertaken of the v{max}=1 limit of the cellular automaton traffic model proposed by Nagel and Paczuski [Phys. Rev. E 51, 2909 (1995)]. The model allows one to analyze the behavior of a traffic jam initiated in an otherwise freely flowing stream of traffic. By mapping onto a discrete-time queueing system, itself related to various problems encountered in lattice combinatorics, exact results are presented in relation to the jam lifetime, the maximum jam length, and the jam mass (the space-time cluster size or integrated vehicle waiting time), both in terms of the critical and the off-critical behavior. This sets existing scaling results in their natural context and also provides several other interesting results in addition.

  17. About the solvability of matrix polynomial equations

    OpenAIRE

    Netzer, Tim; Thom, Andreas

    2016-01-01

    We study self-adjoint matrix polynomial equations in a single variable and prove existence of self-adjoint solutions under some assumptions on the leading form. Our main result is that any self-adjoint matrix polynomial equation of odd degree with non-degenerate leading form can be solved in self-adjoint matrices. We also study equations of even degree and equations in many variables.

  18. Isovectorial pairing in solvable and algebraic models

    International Nuclear Information System (INIS)

    Lerma, Sergio; Vargas, Carlos E; Hirsch, Jorge G

    2011-01-01

    Schematic interactions are useful to gain some insight in the behavior of very complicated systems such as the atomic nuclei. Prototypical examples are, in this context, the pairing interaction and the quadrupole interaction of the Elliot model. In this contribution the interplay between isovectorial pairing, spin-orbit, and quadrupole terms in a harmonic oscillator shell (the so-called pairing-plus-quadrupole model) is studied by algebraic methods. The ability of this model to provide a realistic description of N = Z even-even nuclei in the fp-shell is illustrated with 44 Ti. Our calculations which derive from schematic and simple terms confirm earlier conclusions obtained by using realistic interactions: the SU(3) symmetry of the quadrupole term is broken mainly by the spin-orbit term, but the energies depends strongly on pairing.

  19. Solvable Hydrodynamics of Quantum Integrable Systems

    Science.gov (United States)

    Bulchandani, Vir B.; Vasseur, Romain; Karrasch, Christoph; Moore, Joel E.

    2017-12-01

    The conventional theory of hydrodynamics describes the evolution in time of chaotic many-particle systems from local to global equilibrium. In a quantum integrable system, local equilibrium is characterized by a local generalized Gibbs ensemble or equivalently a local distribution of pseudomomenta. We study time evolution from local equilibria in such models by solving a certain kinetic equation, the "Bethe-Boltzmann" equation satisfied by the local pseudomomentum density. Explicit comparison with density matrix renormalization group time evolution of a thermal expansion in the XXZ model shows that hydrodynamical predictions from smooth initial conditions can be remarkably accurate, even for small system sizes. Solutions are also obtained in the Lieb-Liniger model for free expansion into vacuum and collisions between clouds of particles, which model experiments on ultracold one-dimensional Bose gases.

  20. Solvable Hydrodynamics of Quantum Integrable Systems.

    Science.gov (United States)

    Bulchandani, Vir B; Vasseur, Romain; Karrasch, Christoph; Moore, Joel E

    2017-12-01

    The conventional theory of hydrodynamics describes the evolution in time of chaotic many-particle systems from local to global equilibrium. In a quantum integrable system, local equilibrium is characterized by a local generalized Gibbs ensemble or equivalently a local distribution of pseudomomenta. We study time evolution from local equilibria in such models by solving a certain kinetic equation, the "Bethe-Boltzmann" equation satisfied by the local pseudomomentum density. Explicit comparison with density matrix renormalization group time evolution of a thermal expansion in the XXZ model shows that hydrodynamical predictions from smooth initial conditions can be remarkably accurate, even for small system sizes. Solutions are also obtained in the Lieb-Liniger model for free expansion into vacuum and collisions between clouds of particles, which model experiments on ultracold one-dimensional Bose gases.

  1. Exactly solvable cellular automaton traffic jam model

    Science.gov (United States)

    Kearney, Michael J.

    2006-12-01

    A detailed study is undertaken of the vmax=1 limit of the cellular automaton traffic model proposed by Nagel and Paczuski [Phys. Rev. E 51, 2909 (1995)]. The model allows one to analyze the behavior of a traffic jam initiated in an otherwise freely flowing stream of traffic. By mapping onto a discrete-time queueing system, itself related to various problems encountered in lattice combinatorics, exact results are presented in relation to the jam lifetime, the maximum jam length, and the jam mass (the space-time cluster size or integrated vehicle waiting time), both in terms of the critical and the off-critical behavior. This sets existing scaling results in their natural context and also provides several other interesting results in addition.

  2. Exactly solvable quantum Sturm-Liouville problems

    NARCIS (Netherlands)

    Buyukasik, Sirin A.; Pashaev, Oktay K.; Tigrak-Ulas, Esra

    The harmonic oscillator with time-dependent parameters covers a broad spectrum of physical problems from quantum transport, quantum optics, and quantum information to cosmology. Several methods have been developed to quantize this fundamental system, such as the path integral method, the

  3. Solvable models and hidden symmetries in QCD

    International Nuclear Information System (INIS)

    Yepez-Martinez, Tochtli; Hess, P. O.; Szczepaniak, A.; Civitarese, O.; Lerma H., S.

    2010-01-01

    We show that QCD Hamiltonians at low energy exhibit an SU(2) structure, when only few orbital levels are considered. In case many orbital levels are taken into account we also find a semi-analytic solution for the energy levels of the dominant part of the QCD Hamiltonian. The findings are important to propose the structure of phenomenological models.

  4. Gegenbauer-solvable quantum chain model

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2010-01-01

    Roč. 82, č. 5 (2010), 052113/1-052113/10 ISSN 1050-2947 R&D Projects: GA MŠk LC06002 Institutional research plan: CEZ:AV0Z10480505 Keywords : NON-HERMITIAN HAMILTONIANS * PSEUDO-HERMITICITY * FIELD-THEORY Subject RIV: BE - Theoretical Physics Impact factor: 2.861, year: 2010

  5. Characterization and solvability of quasipolynomial symplectic mappings

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez-Bermejo, Benito [ESCET (Edificio Departamental II), Universidad Rey Juan Carlos, Calle Tulipan S/N, 28933-Mostoles-Madrid (Spain); Brenig, Leon [Service de Physique Theorique et Mathematique, Universite Libre de Bruxelles, Campus Plaine, CP 231, Boulevard du Triomphe, B-1050 Brussels (Belgium)

    2004-02-13

    Quasipolynomial (or QP) mappings constitute a wide generalization of the well-known Lotka-Volterra mappings, of importance in different fields such as population dynamics, physics, chemistry or economy. In addition, QP mappings are a natural discrete-time analogue of the continuous QP systems, which have been extensively used in different pure and applied domains. After presenting the basic definitions and properties of QP mappings in a previous paper, the purpose of this work is to focus on their characterization by considering the existence of symplectic QP mappings. In what follows such QP symplectic maps are completely characterized. Moreover, use of the QP formalism can be made in order to demonstrate that all QP symplectic mappings have an analytical solution that is explicitly and generally constructed. Examples are given.

  6. Phase II clinical development of new drugs

    CERN Document Server

    Ting, Naitee; Ho, Shuyen; Cappelleri, Joseph C

    2017-01-01

    This book focuses on how to appropriately plan and develop a Phase II program, and how to design Phase II clinical trials and analyze their data. It provides a comprehensive overview of the entire drug development process and highlights key questions that need to be addressed for the successful execution of Phase II, so as to increase its success in Phase III and for drug approval. Lastly it warns project team members of the common potential pitfalls and offers tips on how to avoid them.

  7. Solvent Refined Coal-II (SRC-II) detailed environmental plan

    Energy Technology Data Exchange (ETDEWEB)

    1980-10-01

    This document describes environmental research which will: aid in the development of an environmentally acceptable SRC-II process; and provide data for environmental assessment of the process. The SRC-II process is described, criteria for selection of samples to undergo environmental analyses are given, and approximate timelines are presented for obtaining pertinent samples. At this time, the SRC-II process is at the pilot-plant stage of development and a demonstration facility is scheduled to begin operation in 1984. Since design criteria may change, the environmental research described in this document is organized in four phases which correlate with and will provide information early in process development. Phase I research (screening) evaluates samples from existing SRC-II facilities (pilot, process demonstration unit (PDU), bench) which may bracket potential demonstration/commercial practice in terms of physical and chemical criteria. The samples are being subjected to a battery of short-term biomedical and ecological assays. Chemical fractionation and analysis are being performed to determine compounds and compound classes of potential concern. Phase II (baseline) research will evaluate SRC-II materials which are considered most representative of potential demonstration/commercial practice. These materials will be subjected to longer-term, more-extensive biological and ecological analyses relative to effects and environmental fate. Phase III research will examine effects of process modification, control technologies and changing operational conditions on potential environmental properties of SRC-II materials. Phase IV research (onsite monitoring) will develop methods and initiate environmental monitoring for effects at the SRC-II demonstration facility and potential commercial sites. This document also describes industrial hygiene programs which must occur throughout SRC-II process development.

  8. Thiol-functionalized polysilsesquioxane as efficient adsorbent for adsorption of Hg(II) and Mn(II) from aqueous solution

    International Nuclear Information System (INIS)

    Niu, Yuzhong; Qu, Rongjun; Liu, Xiguang; Mu, Lei; Bu, Baihui; Sun, Yuting; Chen, Hou; Meng, Yangfeng; Meng, Lina; Cheng, Lin

    2014-01-01

    Highlights: • PMPSQ was promising adsorbent for the removal of Hg(II) and Mn(II). • The adsorption kinetics followed the pseudo-second-order model. • The adsorption isotherms can be described by the monolayer Langmuir model. • The adsorption was controlled by film diffusion and chemical ion-exchange mechanism. - Abstract: Thiol-functionalized polysilsesquioxane was synthesized and used for the adsorption of Hg(II) and Mn(II) from aqueous solution. Results showed that the optimal pH was about 6 and 5 for Hg(II) and Mn(II), respectively. Adsorption kinetics showed that the adsorption equilibriums were established within 100 min and followed pseudo-second-order model. Adsorption isotherms revealed that the adsorption capacities increased with the increasing of temperature. The adsorption was found to be well described by the monolayer Langmuir isotherm model and took place by chemical ion-exchange mechanism. The thermodynamic properties indicated the adsorption processes were spontaneous and endothermic nature. Selectively adsorption showed that PMPSQ can selectively adsorb Hg(II) from binary ion systems in the presence of the coexistent ions Mn(II), Cu(II), Pb(II), Co(II), and Ni(II). Based on the results, it is concluded that PMPSQ had comparable high adsorption efficiency and could be potentially used for the removal of Hg(II) and Mn(II) from aqueous solution

  9. Quininium tetrachloridozinc(II

    Directory of Open Access Journals (Sweden)

    Li-Zhuang Chen

    2009-10-01

    Full Text Available The asymmetric unit of the title compound {systematic name: 2-[hydroxy(6-methoxyquinolin-1-ium-4-ylmethyl]-8-vinylquinuclidin-1-ium tetrachloridozinc(II}, (C20H26N2O2[ZnCl4], consists of a double protonated quininium cation and a tetrachloridozinc(II anion. The ZnII ion is in a slightly distorted tetrahedral coordination environment. The crystal structure is stabilized by intermolecular N—H...Cl and O—H...Cl hydrogen bonds.

  10. Mineral potential for sediment-hosted copper deposits in the Islamic Republic of Mauritania (phase V, deliverable 75): Chapter K in Second projet de renforcement institutionnel du secteur minier de la République Islamique de Mauritanie (PRISM-II)

    Science.gov (United States)

    Taylor, Cliff D.; Giles, Stuart A.

    2015-01-01

    The presence of Neoproterozoic through Cambrian, continental, siliciclastic sedimentary rocks interbedded with dolomitic carbonates, shales, and glacial tillites similar to the Katanga Supergroup host rocks of the Central African Copperbelt and other sediment-hosted copper-bearing Proterozoic sequences worldwide, is first order criteria for consideration of the Neoproterozoic units of the Taoudeni Basin in Mauritania as prospective for sediment-hosted copper deposits. Review of the National Mineral Occurrences Database (Marsh and Anderson, 2015) and previous literature suggest that only a handful of small sediment-hosted copper occurrences have been found to date in Mauritania and that the resource potential for this deposit type is low. In the northern Taoudeni Basin, the most important occurrence is at Taradent. This occurrence consists of three mineralized horizons in the lower Neoproterozoic Char Group in three outcrop areas separated by alluvium over a strike length of 12 kilometers (km). The most extensively mineralized horizon consists of malachite and disseminated copper sulfides, and is concentrated at the base of a dolomitic interval, consistent with a reduced faciestype sediment-hosted copper deposit model. Additional and poorly described copper occurrences in the Taoudeni Basin margin sedimentary rocks in northeastern Mauritania, such as Chegga Guettatira and Sidi Bara, may be sediment-hosted copper occurrences and extend the potential throughout this portion of the Basin.

  11. Burkina Faso - BRIGHT II

    Data.gov (United States)

    Millennium Challenge Corporation — Millennium Challenge Corporation hired Mathematica Policy Research to conduct an independent evaluation of the BRIGHT II program. The three main research questions...

  12. CHEMICAL SPECIATION OF Pb(II), Cd(II)

    African Journals Online (AJOL)

    Chemical speciation of Pb(II), Cd(II), Hg(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of L-methionine in 0.0-60 % v/v 1,2-propanediol-water mixtures maintaining an ionic strength of 0.16 M at 303 K has been studied pH metrically. The active forms of ligand are LH2+, LH and L-. The predominant species detected are ML, ...

  13. Sequestration of chelated copper by structural Fe(II): Reductive decomplexation and transformation of Cu{sup II}-EDTA

    Energy Technology Data Exchange (ETDEWEB)

    He, Hongping [State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science & Engineering, Tongji University, Shanghai 200092 (China); Wu, Deli, E-mail: wudeli@tongji.edu.cn [State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science & Engineering, Tongji University, Shanghai 200092 (China); Zhao, Linghui [State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science & Engineering, Tongji University, Shanghai 200092 (China); Luo, Cong [School of Civil and Environmental Engineering, Georgia Institute of Technology, GA 30332 (United States); Dai, Chaomeng; Zhang, Yalei [State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science & Engineering, Tongji University, Shanghai 200092 (China)

    2016-05-15

    Highlights: • Structural Fe(II) was found to reveal high sequestration potential in various chelated copper. • Chelated copper was reduced to Cu(0) and Cu{sub 2}O by =Fe(II), whcih was oxidized to Fe{sub 2}O{sub 3}·H{sub 2}O. • Both electron transfer and surface =Fe(II) were found to be crucial during chelated copper reduction. • The indispensible role of reductive decomplexation was identified in chelated copper sequestration. - Abstract: Chelated coppers, such as Cu{sup II}-EDTA, are characteristically refractory and difficult to break down because of their high stability and solubility. Cu{sup II}–EDTA sequestration by structural Fe(II) (=Fe(II)) was investigated intensively in this study. Up to 101.21 mgCu(II)/gFe(II) was obtained by =Fe(II) in chelated copper sequestration under near neutral pH condition (pH 7.70). The mechanism of Cu{sup II}-EDTA sequestration by =Fe(II) was concluded as follows: 3Cu{sup II}–EDTA + 7=Fe(II) + 9H{sub 2}O → Cu(0) ↓ + Cu{sub 2}O ↓ (the major product) + 2Fe{sub 2}O{sub 3}·H{sub 2}O ↓ + 3Fe{sup II}–EDTA +14H{sup +} Novel results strongly indicate that Cu{sup II} reductive transformation induced by surface =Fe(II) was mainly responsible for chelated copper sequestration. Cu(0) generation was initially facilitated, and subsequent reduction of Cu(II) into Cu(I) was closely combined with the gradual increase of ORP (Oxidation-Reduction Potential). Cu-containing products were inherently stable, but Cu{sub 2}O would be reoxidized to Cu(II) with extra-aeration, resulting in the release of copper, which was beneficial to Cu reclamation. Concentration diminution of Cu{sup II}–EDTA within the electric double layer and competitive adsorption were responsible for the negative effects of Ca{sup 2+}, Mg{sup 2+}. By generating vivianite, PO{sub 4}{sup 3−} was found to decrease surface =Fe(II) content. This study is among the first ones to identify the indispensible role of reductive decomplexation in chelated copper

  14. Biosorption of cadmium (II) and lead (II) from aqueous solutions using mushrooms: A comparative study

    Energy Technology Data Exchange (ETDEWEB)

    Vimala, R., E-mail: vimararagu@yahoo.co.in [School of Biotechnology, Chemical and Biomedical Engineering, VIT University, Vellore 632014, Tamil Nadu (India); Das, Nilanjana [School of Biotechnology, Chemical and Biomedical Engineering, VIT University, Vellore 632014, Tamil Nadu (India)

    2009-08-30

    Sorption capacity of oyster mushroom (Pleurotus platypus), button mushroom (Agaricus bisporus) and milky mushroom (Calocybe indica) were evaluated on biosorption of heavy metals, viz. cadmium (II) and lead (II) from aqueous solutions. The optimum sorption conditions were studied for each metal separately. The desired pH of the aqueous solution was found to be 6.0 for the removal of cadmium (II) and 5.0 for removal of lead (II) for all the mushrooms. The percent removal of both the metals was found to increase with the increase in biosorbent dosage and contact time. The fitness of the biosorption data for Langmuir and Freundlich adsorption models was investigated. It was found that biosorption of cadmium (II) and lead (II) ions onto the biomass of the three mushrooms were better suitable to Langmuir than Freundlich adsorption model. P. platypus showed the highest metal uptake potential for cadmium (q{sub max} 34.96 mg/g) whereas A. bisporus exhibited maximum potential for lead (q{sub max} 33.78 mg/g). Milky mushroom showed the lowest metal uptake capacity for both the metals. The present data confirms that mushrooms may be used as efficient biosorbent for the removal of cadmium (II) and lead (II) ions from aqueous solution.

  15. Biosorption of cadmium (II) and lead (II) from aqueous solutions using mushrooms: A comparative study

    International Nuclear Information System (INIS)

    Vimala, R.; Das, Nilanjana

    2009-01-01

    Sorption capacity of oyster mushroom (Pleurotus platypus), button mushroom (Agaricus bisporus) and milky mushroom (Calocybe indica) were evaluated on biosorption of heavy metals, viz. cadmium (II) and lead (II) from aqueous solutions. The optimum sorption conditions were studied for each metal separately. The desired pH of the aqueous solution was found to be 6.0 for the removal of cadmium (II) and 5.0 for removal of lead (II) for all the mushrooms. The percent removal of both the metals was found to increase with the increase in biosorbent dosage and contact time. The fitness of the biosorption data for Langmuir and Freundlich adsorption models was investigated. It was found that biosorption of cadmium (II) and lead (II) ions onto the biomass of the three mushrooms were better suitable to Langmuir than Freundlich adsorption model. P. platypus showed the highest metal uptake potential for cadmium (q max 34.96 mg/g) whereas A. bisporus exhibited maximum potential for lead (q max 33.78 mg/g). Milky mushroom showed the lowest metal uptake capacity for both the metals. The present data confirms that mushrooms may be used as efficient biosorbent for the removal of cadmium (II) and lead (II) ions from aqueous solution.

  16. Studies of valence-bond based quantum mechanical potential-energy surfaces. I. H2 + D2 exchange reaction. II. LiH + H → Li + H2 and LiH + D → LiD + H reactions

    International Nuclear Information System (INIS)

    Freihaut, B.H.

    1975-01-01

    The first phase of this investigation involved the construction of a perfect pairing valence-bond (VB) quantum mechanical potential-energy surfaces for the (H 2 D 2 ) system to compare its results for various geometries to the other prior formulations of such. A plausible four-body pathway for the H 2 --D 2 exchange reaction as shown by a semiempirical Huckel method was explored by the current valence-bond procedure. The second phase of the present investigation involves the formation of a VB based potential-energy surface for the LiH + H → Li + H 2 and LiH + D → LiD + H reaction systems for geometries compatible for a three-center reaction mechanism. No energy acceptable four-body reaction pathway was found for the H 2 --D 2 exchange system. Good agreement was demonstrated with previous ''ab initio'' configuration interaction (CI) studies for the various geometries tested. The square configuration for the H 4 system yielded the lowest barrier height of all the four-body geometries tested although it was still considerably higher than the experimental activation energy for the (H 2 ,D 2 ) system. The barrier height energy for the linear LiH--H configuration agreed well with the one previous work on this system. The barrier height for the LiH--H system increases as the Li--H--H bond angle decreases from 180 0 to 90 0 as well as the Li--H distance at the saddle point. The VB method used herein showed markedly good comparison with recent full CI calculations on the lithium-hydrogen system especially in view of the very limited basis set used in the VB procedure

  17. World War II Homefront.

    Science.gov (United States)

    Garcia, Rachel

    2002-01-01

    Presents an annotated bibliography that provides Web sites focusing on the U.S. homefront during World War II. Covers various topics such as the homefront, Japanese Americans, women during World War II, posters, and African Americans. Includes lesson plan sources and a list of additional resources. (CMK)

  18. Nuclear physics II

    International Nuclear Information System (INIS)

    Elze, T.

    1988-01-01

    This script consisting of two parts contains the matter of the courses Nuclear Pyhsics I and II, as they were presented in the winter term 1987/88 and summer term 1988 for students of physics at Frankfurt University. In the present part II the matter of the summer term is summarized. (orig.) [de

  19. Computing at Belle II

    International Nuclear Information System (INIS)

    Kuhr, Thomas

    2011-01-01

    The next generation B-factory experiment Belle II will collect a huge data sample which is a challenge for the computing system. In this article, the computing model of the Belle II experiment is presented and the core components of the computing system are introduced.

  20. semicarbazide manganese (ii)

    African Journals Online (AJOL)

    DR. AMINU

    The potentiometric studies revealed a pKa of. 5.40 for the Schiff base. The standard Gibb's free energy of Mn(II) and Fe(II) Schiff base complexes determined are -65.79KJmol-1 and -60.35KJmol-1, respectively. The ratio of metal ion to. Schiff base determined potentiometrically and spectrophotometrically for the complex ...

  1. AND Zn(II)

    African Journals Online (AJOL)

    thiopene radical cation. Conductivity measurements. The molar conductance values of the Ni(II) and Zn(II) complexes were recorded in nitrobenzene. The molar conductance values of both the complexes are less than 20 S cm2 mol-1 indicating their non-electrolyte nature. In view of this, the following conclusions are made: ...

  2. and Zn(II)

    African Journals Online (AJOL)

    2017-12-13

    Dec 13, 2017 ... Synthesis, Characterization and Antimicrobial Studies of Cu(II) and Zn(II). Complexes with the Schiff base N-salicylidene-4-chloroaniline. 1Ibrahim, A. K., 2Yusuf, B. A. and 3Hamisu,A. 1,2Department of pure and Industrial Chemistry, Bayero University, Kano. Nigeria. 3Applied Science Department Kaduna ...

  3. Semipermeable membrane devices link site-specific contaminants to effects: PART II - A comparison of lingering Exxon Valdez oil with other potential sources of CYP1A inducers in Prince William Sound, Alaska.

    Science.gov (United States)

    Short, Jeffrey W; Springman, Kathrine R; Lindeberg, Mandy R; Holland, Larry G; Larsen, Marie L; Sloan, Catherine A; Khan, Colin; Hodson, Peter V; Rice, Stanley D

    2008-12-01

    We deployed semipermeable membrane devices (SPMDs) on beaches for 28 days at 53 sites in Prince William Sound (PWS), Alaska, to evaluate the induction potential from suspected sources of cytochrome P450 1A (CYP1A)-inducing contaminants. Sites were selected to assess known point sources, or were chosen randomly to evaluate the region-wide sources. After deployment, SPMD extracts were analyzed chemically for persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons (PAH). These results were compared with hepatic CYP1A enzyme activity of juvenile rainbow trout injected with the same extracts prior to clean-up for the chemical analyses. Increased CYP1A activity was strongly associated with PAH concentrations in extracts, especially chrysene homologues but was not associated with POPs. The only apparent sources of chrysene homologues were lingering oil from Exxon Valdez, asphalt and bunker fuels released from storage tanks during the 1964 Alaska earthquake, creosote leaching from numerous pilings at one site, and PAH-contaminated sediments at Cordova Harbor. Our results indicate that PWS is remarkably free of pollution from PAH when nearby sources are absent as well as from pesticides and PCBs generally.

  4. Evaluation of an approach for the characterization of reactive and available pools of 20 potentially toxic elements in soils: part II--solid-solution partition relationships and ion activity in soil solutions.

    Science.gov (United States)

    Rodrigues, S M; Henriques, B; Ferreira da Silva, E; Pereira, M E; Duarte, A C; Groenenberg, J E; Römkens, P F A M

    2010-12-01

    To assess environmental risks related to contaminants in soil it is essential to predict the available pool of inorganic contaminants at regional scales, accounting for differences between soils from variable geologic and climatic origins. An approach composed of a well-accepted soil extraction procedure (0.01 M CaCl(2)) and empirical Freundlich-type models in combination with mechanistically based models which to date have been used only in temperate regions was applied to 136 soils from a South European area and evaluated for its possible general use in risk assessment. Empirical models based on reactive element pools and soil properties (pH, organic carbon, clay, total Al, Fe and Mn) provided good estimations of available concentrations for a broad range of contaminants including As, Ba, Cd, Co, Cu, Hg, Mo, Ni, Pb, Sb, Se and Zn (r(2): 0.46-0.89). The variation of the pools of total Al in soils expressed the sorptive capacity of aluminosilicates and Al oxides at the surfaces and edges of clay minerals better than the actual variability of clay contents. The approach has led to recommendations for further research with particular emphasis on the impact of clay on the solubility of As and Sb, on the mechanisms controlling Cr and U availability and on differences in binding properties of soil organic matter from different climatic regions. This study showed that such approach may be included with a good degree of certainty for first step risk assessment procedures to identify potential risk areas for leaching and uptake of inorganic contaminants in different environmental settings. Copyright © 2010 Elsevier Ltd. All rights reserved.

  5. Biologically active new Fe(II, Co(II, Ni(II, Cu(II, Zn(II and Cd(II complexes of N-(2-thienylmethylenemethanamine

    Directory of Open Access Journals (Sweden)

    C. SPÎNU

    2008-04-01

    Full Text Available Iron(II, cobalt(II, nickel (II, copper (II, zinc(II and cadmium(II complexes of the type ML2Cl2, where M is a metal and L is the Schiff base N-(2-thienylmethylenemethanamine (TNAM formed by the condensation of 2-thiophenecarboxaldehyde and methylamine, were prepared and characterized by elemental analysis as well as magnetic and spectroscopic measurements. The elemental analyses suggest the stoichiometry to be 1:2 (metal:ligand. Magnetic susceptibility data coupled with electronic, ESR and Mössbauer spectra suggest a distorted octahedral structure for the Fe(II, Co(II and Ni(II complexes, a square-planar geometry for the Cu(II compound and a tetrahedral geometry for the Zn(II and Cd(II complexes. The infrared and NMR spectra of the complexes agree with co-ordination to the central metal atom through nitrogen and sulphur atoms. Conductance measurements suggest the non-electrolytic nature of the complexes, except for the Cu(II, Zn(II and Cd(II complexes, which are 1:2 electrolytes. The Schiff base and its metal chelates were screened for their biological activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the metal chelates were found to possess better antibacterial activity than that of the uncomplexed Schiff base.

  6. Copper(II), cobalt(II), nickel(II) and zinc(II) complexes of Schiff base ...

    Indian Academy of Sciences (India)

    Unknown

    metal (II) complexes with Schiff bases, in the pre- sent paper we report the synthesis and characteriza- tion of Cu(II), Co(II), Ni(II) and Zn(II) complexes of Schiff base derived from the condensation of benzil-2,4-dinitrophenylhydrazone with aniline. The proposed structure of the complexes is shown in chart 1. 2. Experimental.

  7. Mechanism of Cu(II), Cd(II) and Pb(II) ions sorption from aqueous solutions by macroporous poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate)

    Energy Technology Data Exchange (ETDEWEB)

    Nastasović, Aleksandra B., E-mail: anastaso@chem.bg.ac.rs [University of Belgrade, Institute of Chemistry Technology and Metallurgy, Department of Chemistry, Department of Microelectronic Technologies, Njegoševa 12, Belgrade (Serbia); Ekmeščić, Bojana M. [University of Belgrade, Institute of Chemistry Technology and Metallurgy, Department of Chemistry, Department of Microelectronic Technologies, Njegoševa 12, Belgrade (Serbia); and others

    2016-11-01

    Highlights: • Macroporous PGME-deta sorption potential for Pb(II), Cd(II) and Cu(II) was studied. • Sorption kinetics obeyed pseudo-second order model. • Maximal Pb(II), Cd(II) and Cu(II) sorption capacities were 164, 152 and 120 mg g{sup −1}. • AFM indicates that metal sorption changes the size and morphology of PGME-deta. • XPS suggests complexation through the formation of Me−O and Me−N bonds in PGME-deta. - Abstract: The mechanism of Cu(II), Cd(II) and Pb(II) ions sorption from aqueous solutions by macroporous poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (PGME) functionalized by reaction of the pendant epoxy groups with diethylene triamine (PGME-deta) was studied using X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) analysis. Atomic force microscopy (AFM) and scanning energy-dispersive X-ray spectroscopy (SEM-EDX) were used for the determination of surface morphology of the copolymer particles. The sorption behavior of heavy metals Cu(II), Cd(II) and Pb(II) ions sorption was investigated in batch static experiments under non-competitive conditions at room temperature (298 K). The obtained results were fitted to pseudo-first order, pseudo-second order and intraparticle diffusion kinetic model. The kinetics studies showed that Cu(II), Cd(II) and Pb(II) sorption obeys the pseudo-second-order model under all investigated operating conditions with evident influence of pore diffusion.

  8. Removal of Pb(II), Cd(II), Cu(II), and Zn(II) by hematite nanoparticles: effect of sorbent concentration, pH, temperature, and exhaustion.

    Science.gov (United States)

    Shipley, Heather J; Engates, Karen E; Grover, Valerie A

    2013-03-01

    Nanoparticles offer the potential to improve environmental treatment technologies due to their unique properties. Adsorption of metal ions (Pb(II), Cd(II), Cu(II), Zn(II)) to nanohematite was examined as a function of sorbent concentration, pH, temperature, and exhaustion. Adsorption experiments were conducted with 0.05, 0.1, and 0.5 g/L nanoparticles in a pH 8 solution and in spiked San Antonio tap water. The adsorption data showed the ability of nanohematite to remove Pb, Cd, Cu, and Zn species from solution with adsorption increasing as the nanoparticle concentration increased. At 0.5 g/L nanohematite, 100 % Pb species adsorbed, 94 % Cd species adsorbed, 89 % Cu species adsorbed and 100 % Zn species adsorbed. Adsorption kinetics for all metals tested was described by a pseudo second-order rate equation with lead having the fastest rate of adsorption. The effect of temperature on adsorption showed that Pb(II), Cu(II), and Cd(II) underwent an endothermic reaction, while Zn(II) underwent an exothermic reaction. The nanoparticles were able to simultaneously remove multiple metals species (Zn, Cd, Pb, and Cu) from both a pH 8 solution and spiked San Antonio tap water. Exhaustion experiments showed that at pH 8, exhaustion did not occur for the nanoparticles but adsorption does decrease for Cd, Cu, and Zn species but not Pb species. The strong adsorption coupled with the ability to simultaneously remove multiple metal ions offers a potential remediation method for the removal of metals from water.

  9. Belle II production system

    Science.gov (United States)

    Miyake, Hideki; Grzymkowski, Rafal; Ludacka, Radek; Schram, Malachi

    2015-12-01

    The Belle II experiment will record a similar quantity of data to LHC experiments and will acquire it at similar rates. This requires considerable computing, storage and network resources to handle not only data created by the experiment but also considerable amounts of simulated data. Consequently Belle II employs a distributed computing system to provide the resources coordinated by the the DIRAC interware. DIRAC is a general software framework that provides a unified interface among heterogeneous computing resources. In addition to the well proven DIRAC software stack, Belle II is developing its own extension called BelleDIRAC. BelleDIRAC provides a transparent user experience for the Belle II analysis framework (basf2) on various environments and gives access to file information managed by LFC and AMGA metadata catalog. By unifying DIRAC and BelleDIRAC functionalities, Belle II plans to operate an automated mass data processing framework named a “production system”. The Belle II production system enables large-scale raw data transfer from experimental site to raw data centers, followed by massive data processing, and smart data delivery to each remote site. The production system is also utilized for simulated data production and data analysis. Although development of the production system is still on-going, recently Belle II has prepared prototype version and evaluated it with a large scale simulated data production. In this presentation we will report the evaluation of the prototype system and future development plans.

  10. Evolved H II regions

    International Nuclear Information System (INIS)

    Churchwell, E.

    1975-01-01

    A probable evolutionary sequence of H II regions based on six distinct types of observed objects is suggested. Two examples which may deviate from this idealized sequence, are discussed. Even though a size-mean density relation of H II regions can be used as a rough indication of whether a nebula is very young or evolved, it is argued that such a relation is not likely to be useful for the quantitative assignment of ages to H II regions. Evolved H II regions appear to fit into one of four structural types: rings, core-halos, smooth structures, and irregular or filamentary structures. Examples of each type are given with their derived physical parameters. The energy balance in these nebulae is considered. The mass of ionized gas in evolved H II regions is in general too large to trace the nebula back to single compact H II regions. Finally, the morphological type of the Galaxy is considered from its H II region content. 2 tables, 2 figs., 29 refs

  11. Preliminary PBFA II design

    International Nuclear Information System (INIS)

    Johnson, D.L.; VanDevender, J.P.; Martin, T.H.

    1980-01-01

    The upgrade of Sandia National Laboratories particle beam fusion accelerator, PBFA I, to PBFA II presents several interesting and challenging pulsed power design problems. PBFA II requires increasing the PBFA I output parameters from 2 MV, 30 TW, 1 MJ to 4 MV, 100 TW, 3.5 MJ with the constraint of using much of the same PBFA I hardware. The increased PBFA II output will be obtained by doubling the number of modules (from 36 to 72), increasing the primary energy storage (from 4 MJ to 15 MJ), lowering the pulse forming line (PFL) output impedance, and adding a voltage doubling network

  12. Violent Potentials

    DEFF Research Database (Denmark)

    Mikkelsen, Henrik Hvenegaard; Søgaard, Thomas Friis

    2015-01-01

    This article explores the social significance of violence as potentiality and performance among former headhunters. Taking its outset in an ethnographic study of violence and masculinity among the Philippine people known as the Bugkalot, we explore how violence as “performed violent potentiality...... today abandoned headhunting, the potentials for violence and dominance, which the act of headhunting sought to elicit, remains a critical aspect of masculinity. We propose that a focus on the social significance of performative violent potentiality among Bugkalot men can provide general insights...... that can also be used in other contexts to understand how men construct hegemonic masculinity by strategically adopting the interspace of civility and violence....

  13. Mn(II), Zn(II) and VO(II) Schiff

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 113; Issue 3. Synthesis and characterisation of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) Schiff base complexes derived from o-phenylenediamine and acetoacetanilide. N Raman Y Pitchaikani Raja A Kulandaisamy. Inorganic Volume 113 Issue 3 June 2001 pp 183-189 ...

  14. Antibacterial, antimalarial and leishmanicidal activities of Cu (II) and nickel (II) complexes of diclofenac sodium

    International Nuclear Information System (INIS)

    Rehman, F.U.; Khan, M.F.; Khan, G.M.; Khan, H.; Khan, I.U.

    2010-01-01

    Metal complexes are famous for a wide array of chemotherapeutic effects. The current study was designed to synthesize and evaluate unexplored chemotherapeutic effects of Cu (II) and Nickel (II) complexes of the non-steroidal anti-inflammatory drug diclofenac. Nickel complex exhibited significant leishmanicidal activity against Lieshmania major, while the copper complex was found to possess low activity against the same pathogen. Both of the complexes revealed low antibacterial activities and were interestingly failed to produce any considerable antimalarial activity against Plasmodium falciparum 3D7. Selective leishmanicidal activities of Nickel (II) complex of diclofenac needs further improvement to be developed as potential new metal-based leishmanicidal agent.(author)

  15. Multiple endocrine neoplasia (MEN) II

    Science.gov (United States)

    ... medlineplus.gov/ency/article/000399.htm Multiple endocrine neoplasia (MEN) II To use the sharing features on this page, please enable JavaScript. Multiple endocrine neoplasia, type II (MEN II) is a disorder passed ...

  16. Being a potentially responsible party

    International Nuclear Information System (INIS)

    Ronan, J.T.

    1989-01-01

    This paper reports on CERCLA II- ability for the unlucky potentially responsible parties (PRPs) which is a Draconian form of strict, joint and several liability with limited statutory defenses that in most cases are impossible to establish. CERCLA vigorously employs these legal concepts, stretching a PRP's financial exposure to the limits necessary to meet the enormous financial costs of remediation

  17. Mucopolysaccharidosis type II

    Science.gov (United States)

    Genetic counseling is recommended for couples who want to have children and who have a family history of MPS II. Prenatal testing is available. Carrier testing for female relatives of affected males is available at a few centers.

  18. NNDSS - Table II. Vibriosis

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table II. Vibriosis - 2017. In this Table, provisional cases of selected notifiable diseases (≥1,000 cases reported during the preceding year), and selected...

  19. The Belle II Experiment

    CERN Document Server

    Kahn, J

    2017-01-01

    Set to begin data taking at the end of 2018, the Belle II experiment is the next-generation B-factory experiment hosted at KEK in Tsukuba, Japan. The experiment represents the cumulative effort from the collaboration of experimental and detector physics, computing, and software development. Taking everything learned from the previous Belle experiment, which ran from 1998 to 2010, Belle II aims to probe deeper than ever before into the field of heavy quark physics. By achieving an integrated luminosity of 50 ab−1 and accumulating 50 times more data than the previous experiment across its lifetime, along with a rewritten analysis framework, the Belle II experiment will push the high precision frontier of high energy physics. This paper will give an overview of the key components and development activities that make the Belle II experiment possible.

  20. NNDSS - Table II. Vibriosis

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table II. Vibriosis - 2018. In this Table, provisional cases of selected notifiable diseases (≥1,000 cases reported during the preceding year), and selected...

  1. Gamble II Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Gamble II produces a high-voltage (2 MV), high-current (1 MA), short (100 ns) pulse of energy of either positive or negative polarity. This terawatt power...

  2. NNDSS - Table II. Vibriosis

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table II. Vibriosis - 2018. In this Table, provisional cases of selected notifiable diseases (≥1,000 cases reported during the preceding year), and...

  3. NNDSS - Table II. Vibriosis

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table II. Vibriosis - 2017. In this Table, provisional cases of selected notifiable diseases (≥1,000 cases reported during the preceding year), and...

  4. Disruption Rose Tinted II

    OpenAIRE

    Livingstone, Andrew

    2009-01-01

    'Disruption - Rose Tinted II' continues to engage narratives of historical English china as previously explored in the work 'Rose Tinted'. This work engages the sleepy rural idyll which is overlaid with visual contemporary social commentary.

  5. Leo II PC

    Data.gov (United States)

    Kansas Data Access and Support Center — LEO II is a second-generation software system developed for use on the PC, which is designed to convert location references accurately between legal descriptions and...

  6. Tokapole II device

    International Nuclear Information System (INIS)

    Sprott, J.G.

    1978-05-01

    A discussion is given of the design and operation of the Tokapole II device. The following topics are considered: physics considerations, vacuum vessel, poloidal field, ring and support design, toroidal field, vacuum system, initial results, and future plans

  7. Potential Theory

    CERN Document Server

    Lukeš, Jaroslav; Netuka, Ivan; Veselý, Jiří

    1988-01-01

    Within the tradition of meetings devoted to potential theory, a conference on potential theory took place in Prague on 19-24, July 1987. The Conference was organized by the Faculty of Mathematics and Physics, Charles University, with the collaboration of the Institute of Mathematics, Czechoslovak Academy of Sciences, the Department of Mathematics, Czech University of Technology, the Union of Czechoslovak Mathematicians and Physicists, the Czechoslovak Scientific and Technical Society, and supported by IMU. During the Conference, 69 scientific communications from different branches of potential theory were presented; the majority of them are in­ cluded in the present volume. (Papers based on survey lectures delivered at the Conference, its program as well as a collection of problems from potential theory will appear in a special volume of the Lecture Notes Series published by Springer-Verlag). Topics of these communications truly reflect the vast scope of contemporary potential theory. Some contributions deal...

  8. Copper(II), cobalt(II) and nickel(II) complexes of juglone: synthesis, structure, DNA interaction and enhanced cytotoxicity.

    Science.gov (United States)

    Tabrizi, Leila; Fooladivanda, Mahrokh; Chiniforoshan, Hossein

    2016-12-01

    Three novel copper(II), cobalt(II), and nickel(II) complexes of juglone (Jug) containing 1,10-phenanthroline (phen) ligand, [M(Jug) 2 (phen)] (M = Cu(II), 1, Co(II), 2, and Ni(II), 3), have been synthesized and characterized using, elemental analysis and spectroscopic studies. Their interactions with calf thymus DNA were investigated using viscosity measurements, UV-visible and fluorescence spectrophotometric methods. The catalytic activities on DNA cleavage of the complexes 1-3 were studied, which copper complex 1 showed better catalyst activity in the DNA cleavage process than complexes 2 and 3. The in vitro cytotoxic potential of the complexes 1-3 against human cervical carcinoma (HeLa), human liver hepatocellular carcinoma (HepG-2), and human colorectal adenocarcinoma (HT-29) cells indicated their promising antitumor activity with quite low IC 50 values in the range of 0.09-1.89 μM, which are 75 times lower than those of cisplatin.

  9. Computing at Belle II

    Science.gov (United States)

    Kuhr, Thomas

    2012-12-01

    Belle II, a next-generation B-factory experiment, will search for new physics effects in a data sample about 50 times larger than the one collected by its predecessor, the Belle experiment. To match the advances in accelerator and detector technology, the computing system and the software have to be upgraded as well. The Belle II computing model is presented and an overview of the distributed computing system and the offline software framework is given.

  10. Computing at Belle II

    International Nuclear Information System (INIS)

    Kuhr, Thomas

    2012-01-01

    Belle II, a next-generation B-factory experiment, will search for new physics effects in a data sample about 50 times larger than the one collected by its predecessor, the Belle experiment. To match the advances in accelerator and detector technology, the computing system and the software have to be upgraded as well. The Belle II computing model is presented and an overview of the distributed computing system and the offline software framework is given.

  11. ASTRID II satellit projekt

    DEFF Research Database (Denmark)

    Jørgensen, John Leif; Primdahl, Fritz

    1997-01-01

    The report describes the instruments developed for the Swedish micro satellite "ASTRID II". Specifications of the two instruments realized under this contract, a Stellar Compass and a CSC magnetometer are given follwed by a description of the project status and plan.......The report describes the instruments developed for the Swedish micro satellite "ASTRID II". Specifications of the two instruments realized under this contract, a Stellar Compass and a CSC magnetometer are given follwed by a description of the project status and plan....

  12. Potential bags

    International Nuclear Information System (INIS)

    Ferreira, P.L.; Tomio, L.

    1992-01-01

    In this paper, relativistic confining potential models, endowed with bag constants associated to volume energy terms, are investigated. In contrast to the usual bag model, these potential bags are distinguished by having smeared bag surfaces. Based on the dynamical assumptions underlying the fuzzy bag model, these bag constants are derived from the corresponding energy-momentum tensor. Explicit expressions for the single-quark energies and for the nucleon bag constant are obtained by means of an improved analytical version of the saddle-point variational method for the Dirac equation with confining power-law potentials of the scalar plus vector (S + V) or pure scalar (S) type

  13. assessment of slope stability around gilgel gibe-ii hydroelectric

    African Journals Online (AJOL)

    preferred customer

    ... are steep and valleys are deep with low vegetation cover. Along the road from Fofa town to powerhouse II, the slope cuts are steep, which overhang at places. Thus, an attempt has been made to analyze the stability condition of potential unstable slopes along the road between Fofa town and Gilgel-Gibe Hydro- power II.

  14. Equilibrium Sorption Studies of Hg (II) Ions from Aqueous Solution ...

    African Journals Online (AJOL)

    The potential of swamp arum (Lasimorpha senegalensis) seeds as a low-cost adsorbent for the removal of Hg (II) ions from aqueous solution was investigated in this study. The influence of initial metal concentration on the percent adsorption of Hg (II) ions onto powdered swamp arum seeds was studied in a batch system ...

  15. DNA binding and biological activity of mixed ligand complexes of Cu(II, Ni(II and Co(II with quinolones and N donor ligand

    Directory of Open Access Journals (Sweden)

    S.M M Akram

    2015-10-01

    Full Text Available  AbstractMixed ligand complexes of  Cu(II, Ni(II and Co(II have been synthesized by using levofloxacin and bipyridyl and characterized using spectral and analytical techniques. The binding behavior of the Ni(II and Cu(II complexes with herring sperm DNA(Hs-DNA were determined using electronic absorption titration, viscometric measurements and cyclic voltammetry measurements. The binding constant calculated  for Cu(II and Ni(II complexes are 2.0 x 104 and 4.0 x 104 M-1 respectively. Detailed analysis reveals that these metal complexes interact with DNA through intercalative binding mode. The nuclease activity of  Cu(II and Ni(II complexes with ct-DNA was carried out using agarose gel electrophoresis technique. The antioxidant activities for the synthesized complexes have been tested and the antibacterial activity for Ni(II complex was also checked.Key words: Intercalation, hypochromism, red shift and  peak potential.

  16. SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo.

    Science.gov (United States)

    Yang, Li; Weng, Wei; Sun, Zhi-Xin; Fu, Xian-Jie; Ma, Jun; Zhuang, Wen-Fang

    2015-05-15

    Previous studies have identified sphingosine kinase 1 (SphK1) as a potential drug target for treatment of acute myeloid leukemia (AML). In the current study, we investigated the potential anti-leukemic activity of a novel and specific SphK1 inhibitor, SKI-II. We demonstrated that SKI-II inhibited growth and survival of human AML cell lines (HL-60 and U937 cells). SKI-II was more efficient than two known SphK1 inhibitors SK1-I and FTY720 in inhibiting AML cells. Meanwhile, it induced dramatic apoptosis in above AML cells, and the cytotoxicity by SKI-II was almost reversed by the general caspase inhibitor z-VAD-fmk. SKI-II treatment inhibited SphK1 activation, and concomitantly increased level of sphingosine-1-phosphate (S1P) precursor ceramide in AML cells. Conversely, exogenously-added S1P protected against SKI-II-induced cytotoxicity, while cell permeable short-chain ceramide (C6) aggravated SKI-II's lethality against AML cells. Notably, SKI-II induced potent apoptotic death in primary human AML cells, but was generally safe to the human peripheral blood mononuclear cells (PBMCs) isolated from healthy donors. In vivo, SKI-II administration suppressed growth of U937 leukemic xenograft tumors in severe combined immunodeficient (SCID) mice. These results suggest that SKI-II might be further investigated as a promising anti-AML agent. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. POTENTIOMETRIC STUDIES OF NICKEL (II) AND COPPER (II ...

    African Journals Online (AJOL)

    DR. AMINU

    2005) potentiometric studies on manganese (II) and cobalt (II) acetylacetonate complexes, where the two metal complexes have been found to show high formation constant of 9.52 x 1013 and 7.89 x 1013 for the Mn(II) and Co(II) complexes, respectively. In that paper we reported that when exposed to air, the coordination ...

  18. Potentiometric and spectrometric study: Copper (II), nickel (II) and ...

    Indian Academy of Sciences (India)

    hetero-binuclear complexes; imidazole; metal(II); equilibrium study. Abstract. Equilibrium and solution structural study of mixed-metal-mixed-ligand complexes of Cu(II), Ni(II) and Zn(II) with L-cysteine, L-threonine and imidazole are conducted in ...

  19. Multipurpose Electric Potential Sensor for Spacecraft Applications, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The original goal of Phase I was to study the feasibility of developing an electric sensor that can be used for as many NASA sensing applications as possible. During...

  20. Synthesis and structure of copper(II) complexes: Potential cyanide ...

    Indian Academy of Sciences (India)

    Research Laboratories (SRL), India. The ligands were prepared following the reported procedure.53 Micro- analysis (C, H, N) was performed using a Perkin- .... coccus aureus (MTCC 2522) and three Gram negative bacteria viz. Pseudomonas aeruginosa (MTCC 741),. Shigella dysenteriae (Clinical isolate) and Escherichia.

  1. II-VI semiconductor compounds

    CERN Document Server

    1993-01-01

    For condensed matter physicists and electronic engineers, this volume deals with aspects of II-VI semiconductor compounds. Areas covered include devices and applications of II-VI compounds; Co-based II-IV semi-magnetic semiconductors; and electronic structure of strained II-VI superlattices.

  2. Violent potentials

    DEFF Research Database (Denmark)

    Mikkelsen, Henrik Hvenegaard; Friis Søgaard, Thomas

    2016-01-01

    This article explores the social significance of violence as potentiality and performance among former headhunters engaged in ritual killings. Taking its outset in an ethnographic study of violence and masculinity among the Philippine people known as the Bugkalot, we explore how violence....... While most Bugkalot men have today abandoned headhunting, the potentials for violence and dominance, which the act of headhunting sought to elicit, remains a critical aspect of masculinity. We propose that a focus on the social significance of performative violent potentiality among Bugkalot men can...... provide general insights that can also be used in other contexts to understand how men construct hegemonic masculinity by strategically adopting the interspace of civility and violence....

  3. VATICANO II CONCILIO DOCTRINAL?

    Directory of Open Access Journals (Sweden)

    Horacio Bojorge

    1970-01-01

    Full Text Available It is a century since the army of Victor Manuel invaded Rome and put an end to Vatican I. In this article we try to understand Vatican II linking it to the previous circumtances and binding it to its doctrinal and pastoral character. Vatican II omitted many subjects that seemed important, e. g. not giving any dogmatic definitions. Contrasting with the Tridentine and Vatican I, that were mostly doctrinal, Vatican II was pastoral. But it was also doctrinal as were the two previous also pastoral. The Constitution "Dei Verbum" brings forth the intentions that led John XXIII to summon the Council in 5-8-1962. The world looked confused and agitated. What could the Church do?

  4. SYNTHESIS AND CHARACTERIZATION OF SALICYLALDAZINE AND ITS METAL (II) COMPLEXES DERIVED FROM METAL (II) CHLORIDES

    OpenAIRE

    Jamila wazir

    2016-01-01

    The salicylaldazine (ligand) and its metal (II) complexes like copper (II), nickel (II), zinc (II), cobalt (II) and manganese (II) complexes has been synthesized and characterized by different techniques using FTIR, UV-VIS spectroscopy. The ligand (salicylaldazine) is synthesized by the condensation reaction of salicylaldehyde and hydrazine sulfate. The salicylaldazine metal (II) complexes like Cu (II) , Ni(II), Zn (II), Co(II), Mn(II) were prepared by using metal (II) chloride in dioxane. Th...

  5. Datalogger usando nios ii

    OpenAIRE

    Campoverde Rugel, Luis Enrique; Velásquez Vargas, Washington Adrián; Ponguillo, Ronald

    2013-01-01

    El presente proyecto consiste en la implementación de un Datalogger utilizando el microprocesador NIOS II el cual fue embebido en el FPGA CYCLONE II que se encuentra integrada en la tarjeta de desarrollo ALTERA DE2, el cual obtiene datos de distintos sensores y los almacena en una tarjeta SD Card. Para la realización del proyecto se aplican cuatro etapas. La primera etapa está basada en obtener los datos mediante el uso de sensores y la transmisión usando un PIC, la siguiente etapa se basa...

  6. Calculus II For Dummies

    CERN Document Server

    Zegarelli, Mark

    2012-01-01

    An easy-to-understand primer on advanced calculus topics Calculus II is a prerequisite for many popular college majors, including pre-med, engineering, and physics. Calculus II For Dummies offers expert instruction, advice, and tips to help second semester calculus students get a handle on the subject and ace their exams. It covers intermediate calculus topics in plain English, featuring in-depth coverage of integration, including substitution, integration techniques and when to use them, approximate integration, and improper integrals. This hands-on guide also covers sequences and series, wit

  7. ECLESIOLOGIA DO VATICANO II

    Directory of Open Access Journals (Sweden)

    Víctor Codina

    2013-01-01

    Full Text Available Não se pode compreender a eclesiologia do Vaticano II sem conhecer a vida, o estilo pastoral e o carisma de João XXIII, que convocou o Concílio e abriu o caminho em direção a uma nova configuração eclesial que acabava com séculos de uma Igreja de Cristandade. O Vaticano II implica uma transição de uma Igreja clerical a uma Igreja Povo de Deus, povo de batizados. A passagem de uma Igreja juridicista e legalista a uma Igreja Mistério de comunhão em Cristo. Mudar de uma Igreja triunfalista e ligada ao poder mundano a uma Igreja vivificada pela força renovadora do Espírito. A Igreja está a caminho rumo ao Reino de Deus juntamente com todos os cristãos e com toda a humanidade. A recepção do Vaticano II supõe uma conversão pastoral: voltar ao Evangelho e abrir-se aos novos sinais dos tempos seguindo o Espírito que inspirou João XXIII. ABSTRACT: You cannot understand the Ecclesiology of Vatican II without knowing the life, the pastoral style and the charisma of John XXIII, who convened the Council and opened the way toward a new ecclesial setting that ended centuries of a church of Christendom. The Vatican II involves a transition from a clerical Church to a “People (baptized people of God” Church. The Vatican II implies the passage from a juridical and legalistic Church to a Church as the Mystery of the communion in Christ. The Vatican II implies the change from a triumphalistic Church and connected to worldly power to a Church vivified by the renewing force of the Spirit. The Church is on its way toward the Kingdom of God together with all Christians and all mankind. The reception of the Vatican II supposes a pastoral conversion: a return to the Gospel and openness to new signs of the times following the Spirit that inspired John XXIII.

  8. Eight joint BER II and BESSY II users meeting. Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-07-01

    The following topics were dealt with: Accelerator operation and projecs, photon science and instrumentation at BESSY II, status of energy materials in-situ Lab at BESSY II, high resolution spectrometer PEAXIS at BESSY II, sample environment at BESSY II, molecular control mechanisms in the Brr2 RNA helicase for efficient and regulated splicing, the Li conversion reaction of 4CoFe{sub 2}O{sub 4} nanoparticles, buried interfaces in lithium ion batteries probed with HAXPES, ARPES studies of the STO(001) 2DEG, all-in/all-out magnetic order in rare earth iridates, oxygen reduction reaction on graphene in Li-air batteries, electronic order in high-T{sub c} superconductors, in-siu observation of novel switching phenomena in highly porous metal-organic frameworks, photoinduced demagnetization and insulator-to-metal transition in ferromagnetic insulating BaFeO{sub 3} thin films, ARPES measurement of the ferroelectric bulk Rashba system GeTe, bisphenol A on Cu(111) and Ag(111), reverse water-gas shift or Sabathier methanation on N(110), structural studies of molecular machines, multi-MHz time-of-flight electronic band-structure imaging of graphene on Ir(111), diffusion pathways in ion conductors, ground-state potential energy surfaces around selected atoms from resonant inelastic X-ray scattering, solar energy in an emerging country, in-situ neutron analysis of electrode materials for electrochemical energy storage, structure and transport properties in thermoelectric skutterudites, investigation of the interphase formation on solid lithium-ion conductors by neutron reflectometry, load partitin and damage characterization of cast AlSi{sub 12}CuMgNi alloy with ceramic reinforcement, methane adsorption in highly porous metal-organics, structure and magnetic interactions in dimer system Ba{sub (3-x)}Sr{sub x}Cr{sub 2}O{sub 8}, distribution of S in C-S nanocomposites, current status of HFM-EXED FACITIY; SPIN NEAMTICITY IN s=1/2 frustrated zigzag chaIN β-TeVO{sub 4}, electronic

  9. Cu (II), Zn (II) andMn (II) complexes of poly (methyl vinyl ether-alt ...

    Indian Academy of Sciences (India)

    MVE-alt-MA)) with Zn(II), Mn(II) and Cu(II) ions were synthesized from the reaction of the aqueous solution of copolymer and metal(II) chlorides at different temperatures ranging from 25° to 40°C. Elemental analysis of themetal-polymer complexes ...

  10. Groundwater Potential

    African Journals Online (AJOL)

    big timmy

    INTEGRATION OF HYDROGEOPHYSICAL AND REMOTE SENSING DATA IN THE. ASSESSMENT OF GROUNDWATER POTENTIAL OF THE BASEMENT COMPLEX. TERRAIN OF EKITI STATE, SOUTHWESTERN NIGERIA. 1. 2. 3. 4. Bayowa O.G., Olorunfemi M.O., Akinluyi F.O., and Ademilua O.L. 1Department of Earth ...

  11. Synthesis and characterization of a tetraaza macrocyclic ligand and its cobalt(II, nickel(II and copper(II complexes

    Directory of Open Access Journals (Sweden)

    SULEKH CHANDR

    2010-07-01

    Full Text Available Co(II, Ni(II, and Cu(II complexes with a tetradentate nitrogen donor [N4] macrocyclic ligand, viz. 6,15-dimethyl-8,17diphenyl-7,16-dihydrodibenzo[b,i][1.4.8.11]tetraazacyclotetradecine, were synthesized. Their structures were determined based on elemental analyses, molar conductance and magnetic susceptibility measurements, and IR, 1H-NMR (ligand and electronic spectral studies. Based on analytical and molar conductance data, the complexes may be formulated as [M(LCl2] and [M’(L]Cl2 (where M = Co(II and Cu(II, and M’ = Ni(II due to their non-electrolytic and 1:2 electrolytic nature. Based on spectral studies, an octahedral geometry was assigned for the Co(II complex, whereas square-planar and tetragonal geometry were proposed for the Ni(II and Cu(II complexes, respectively. The synthesized ligand and its complexes were screened for fungicidal activity against two pathogenic fungi (i.e., Fusarium moniliformae and Rhizoctonia solani to assess their growth inhibiting potential.

  12. Influence of Arsenic (III, Cadmium (II, Chromium (VI, Mercury (II, and Lead (II Ions on Human Triple Negative Breast Cancer (HCC1806 Cell Cytotoxicity and Cell Viability

    Directory of Open Access Journals (Sweden)

    Tsdale F. Mehari

    2017-01-01

    Full Text Available The hazardous consequences of heavy metal ions (HMIs on human health necessitate the immediate need to probe fundamentally the interactions and cytotoxic effects of HMIs on humans. This study investigated the influence of five toxic HMIs (arsenic (As (III, cadmium (Cd (II, chromium (Cr (VI, mercury (Hg (II, and lead (Pb (II on human TNBC (HCC 1806 cell viability using optical microscopy, trypan blue dye-exclusion assays, and flow cytometry. The TNBC cells were exposed to varying concentrations of HMIs for 24 and 48 hours. We evaluated the influence of the concentrations and duration of HMIs exposure on TNBC cell viability. Light microscopy, cell viability assays, revealed that after 48-hour treatment of TNBC cells with 1 x 10-5 M of As (III, Cd (II, Hg (II, Cr (IV, and Pb (II resulted in cell viabilities of 23%, 34%, 35%, 56%, 91% respectively, suggesting that As (III has the greatest cytotoxicity (77% cell death while Pb (II showed the least (9% cell death. Furthermore, flow cytometry revealed that while Pb (II, As (III and Cr (IV had significant increases in cell death, Hg (II caused a G1 arrest. Together, this study revealed that HMIs cause a differential cytotoxic effect on TNBC cells and suggest that they may have very different genotoxic targets and implications in their mutagenic potential.

  13. Synthesis and characterization of VO(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of chromone based azo-linked Schiff base ligand.

    Science.gov (United States)

    Anitha, C; Sheela, C D; Tharmaraj, P; Johnson Raja, S

    2012-12-01

    Azo-Schiff-base complexes of VO(II), Co(II), Ni(II), Cu(II) and Zn(II) have been synthesized and characterized by elemental analysis, IR, UV-Vis, (1)H NMR, mass spectra, molar conductance, magnetic susceptibility measurement, electron spin resonance (EPR), CV, fluorescence, NLO and SEM. The conductance data indicate the nonelectrolytic nature of the complexes, except VO(II) complex which is electrolytic in nature. On the basis of electronic spectra and magnetic susceptibility octahedral geometry has been proposed for the complexes. The EPR spectra of copper and oxovanadium complexes in DMSO at 300 and 77K were recorded and its salient features are reported. The redox behavior of the copper(II) complex was studied using cyclic voltammetry. The in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli, Salmonella enterica typhi, Bacillus subtilis and Candida strains was studied and compared with that of free ligand by well-diffusion technique. The azo Schiff base exhibited fluorescence properties originating from intraligand (π-π(*)) transitions and metal-mediated enhancement is observed on complexation and so the synthesized complexes can serve as potential photoactive materials as indicated from their characteristic fluorescence properties. On the basis of the optimized structures, the second-order nonlinear optical properties (NLO) are calculated by using second-harmonic generation (SHG) and also the surface morphology of the complexes was studied by SEM. Copyright © 2012 Elsevier B.V. All rights reserved.

  14. Removal of Cd(II) and Pb(II) ions from aqueous solutions by synthetic mineral adsorbent: Performance and mechanisms

    Science.gov (United States)

    Chen, Gongning; Shah, Kinjal J.; Shi, Lin; Chiang, Pen-Chi

    2017-07-01

    A synthetic mineral adsorbent (SMA) was prepared by mechanochemical treatments of a solid-state mixture containing illite, wollastonite, gypsum, limestone and dolomite powder at a molar ration of 1:1:1:12:3. The XRD patterns revealed that many newly-generated minerals, namely montmorillonite, laumonite and gismondine (zeolite facies), grossular, gehlenite and calcium silicate were observed in SMA residual after full hydration. The potential of SMA for the removal of Cd(II) and Pb(II) ions from aqueous solution was investigated by batch mode. The effects of pH, concentration of adsorbate, contact time, SMA concentration and temperature on adsorption performance of SMA for Cd(II) and Pb(II) over SMA were studied. The results indicate that the adsorption process was found to follow pseudo-second-order kinetic model and Freundlich isotherm model. The maximum monolayer capacity obtained from the Langmuir isotherm at 25 °C was 47.0 and 143.3 mg g-1 for Cd(II) and Pb(II) ions, respectively. The adsorbed Cd(II) and Pb(II) can hardly be recovered at pH 3.0 but can completely recovered at pH 1.0 and 0.5, respectively. Ion exchange of Cd(II) and Pb(II) for Ca2+ was found to be the principal mechanism in the removal of Cd(II) and Pb(II) from aqueous solution by SMA, followed by adsorption and precipitation. From the investigation, it is concluded that SMA could be a useful environment-friendly, inexpensive and effective tool for removal of high amounts of toxic Cd(II) and Pb(II) ions from aquatic ecosystems.

  15. PEP-II prototype klystron

    International Nuclear Information System (INIS)

    Fowkes, W.R.; Caryotakis, G.; Lee, T.G.; Pearson, C.; Wright, E.L.

    1993-04-01

    A 540-kW continuous-wave (cw) klystron operating at 476 MHz was developed for use as a power source for testing PEP-II rf accelerating cavities and rf windows. It also serves as a prototype for a 1.2 MW cw klystron presently being developed as a potential rf source for asymmetric colliding ring use. The design incorporates the concepts and many of the parts used in the original 353 MHz PEP klystron developed sixteen years ago. The superior computer simulation codes available today result in improved performance with the cavity frequencies, drift lengths, and output circuit optimized for the higher frequency.The design and operating results of this tube are described with particular emphasis on the factors which affect efficiency and stability

  16. Workshop 96. Part II

    International Nuclear Information System (INIS)

    1995-12-01

    Part II of the seminar proceedings contains contributions in various areas of science and technology, among them materials science in mechanical engineering, materials science in electrical, chemical and civil engineering, and electronics, measuring and communication engineering. In those areas, 6 contributions have been selected for INIS. (P.A.)

  17. Amorphous iron (II) carbonate

    DEFF Research Database (Denmark)

    Sel, Ozlem; Radha, A.V.; Dideriksen, Knud

    2012-01-01

    Abstract The synthesis, characterization and crystallization energetics of amorphous iron (II) carbonate (AFC) are reported. AFC may form as a precursor for siderite (FeCO3). The enthalpy of crystallization (DHcrys) of AFC is similar to that of amorphous magnesium carbonate (AMC) and more...

  18. and copper(II)

    Indian Academy of Sciences (India)

    Unknown

    characterization of several imidazolate-bridged binuclear copper(II) complexes have been reported 1–17. ... of the desired complex formed were collected, washed with ethanol and dried in vacuo at room temperature. .... 16. Sigel H (ed.) 1981 Metal ions in biological system (New York: Marcel Dekker) vol 13, p. 259. 17.

  19. CULTIVATION OF LEPTOSPIRAE II.

    Science.gov (United States)

    Stalheim, O. H. V.; Wilson, J. B.

    1964-01-01

    Stalheim, O. H. V. (University of Wisconsin, Madison), and J. B. Wilson. Cultivation of leptospirae. II. Growth and lysis in synthetic medium. J. Bacteriol. 88:55–59. 1964.—Differences were found in the ability of leptospirae to grow in a synthetic medium; 43 strains, consisting of 16 serotypes, were tested and designated as either type I or type II. Type I leptospirae did not grow; type II grew and could be subcultured. The lytic effect of several lipids was measured with Leptospira pomona and L. canicola as representatives of type I and II leptospirae, respectively. L. pomona organisms were rapidly lysed by the monoolein of the synthetic medium and by other lipids as well; L. canicola cells were consistently more resistant. Although both organisms incorporated similar amounts of label when incubated in the presence of oleic-1-C14 acid, only L. canicola grew in a modified, nonlytic synthetic medium. No differences were found in susceptibility to lysis between virulent and avirulent L. canicola organisms. Mutant type I leptospirae grown in synthetic medium had increased resistance to lysis by surface-active agents; they were poorly agglutinated by antiserum. The role of protein in the growth and antigenicity of type I leptospirae is discussed. PMID:14197906

  20. The Bipolar II Depression Questionnaire: A Self-Report Tool for Detecting Bipolar II Depression.

    Directory of Open Access Journals (Sweden)

    Chi Ming Leung

    Full Text Available Bipolar II (BP-II depression is often misdiagnosed as unipolar (UP depression, resulting in suboptimal treatment. Tools for differentiating between these two types of depression are lacking. This study aimed to develop a simple, self-report screening instrument to help distinguish BP-II depression from UP depressive disorder. A prototype BP-II depression questionnaire (BPIIDQ-P was constructed following a literature review, panel discussions and a field trial. Consecutively assessed patients with a diagnosis of depressive disorder or BP with depressive episodes completed the BPIIDQ-P at a psychiatric outpatient clinic in Hong Kong between October and December 2013. Data were analyzed using discriminant analysis and logistic regression. Of the 298 subjects recruited, 65 (21.8% were males and 233 (78.2% females. There were 112 (37.6% subjects with BP depression [BP-I = 42 (14.1%, BP-II = 70 (23.5%] and 182 (62.4% with UP depression. Based on family history, age at onset, postpartum depression, episodic course, attacks of anxiety, hypersomnia, social phobia and agoraphobia, the 8-item BPIIDQ-8 was constructed. The BPIIDQ-8 differentiated subjects with BP-II from those with UP depression with a sensitivity/specificity of 0.75/0.63 for the whole sample and 0.77/0.72 for a female subgroup with a history of childbirth. The BPIIDQ-8 can differentiate BP-II from UP depression at the secondary care level with satisfactory to good reliability and validity. It has good potential as a screening tool for BP-II depression in primary care settings. Recall bias, the relatively small sample size, and the high proportion of females in the BP-II sample limit the generalization of the results.

  1. The Bipolar II Depression Questionnaire: A Self-Report Tool for Detecting Bipolar II Depression

    Science.gov (United States)

    Leung, Chi Ming; Yim, Chi Lap; Yan, Connie T. Y.; Chan, Cheuk Chi; Xiang, Yu-Tao; Mak, Arthur D. P.; Fok, Marcella Lei-Yee; Ungvari, Gabor S.

    2016-01-01

    Bipolar II (BP-II) depression is often misdiagnosed as unipolar (UP) depression, resulting in suboptimal treatment. Tools for differentiating between these two types of depression are lacking. This study aimed to develop a simple, self-report screening instrument to help distinguish BP-II depression from UP depressive disorder. A prototype BP-II depression questionnaire (BPIIDQ-P) was constructed following a literature review, panel discussions and a field trial. Consecutively assessed patients with a diagnosis of depressive disorder or BP with depressive episodes completed the BPIIDQ-P at a psychiatric outpatient clinic in Hong Kong between October and December 2013. Data were analyzed using discriminant analysis and logistic regression. Of the 298 subjects recruited, 65 (21.8%) were males and 233 (78.2%) females. There were 112 (37.6%) subjects with BP depression [BP-I = 42 (14.1%), BP-II = 70 (23.5%)] and 182 (62.4%) with UP depression. Based on family history, age at onset, postpartum depression, episodic course, attacks of anxiety, hypersomnia, social phobia and agoraphobia, the 8-item BPIIDQ-8 was constructed. The BPIIDQ-8 differentiated subjects with BP-II from those with UP depression with a sensitivity/specificity of 0.75/0.63 for the whole sample and 0.77/0.72 for a female subgroup with a history of childbirth. The BPIIDQ-8 can differentiate BP-II from UP depression at the secondary care level with satisfactory to good reliability and validity. It has good potential as a screening tool for BP-II depression in primary care settings. Recall bias, the relatively small sample size, and the high proportion of females in the BP-II sample limit the generalization of the results. PMID:26963908

  2. Potential theory

    CERN Document Server

    Helms, Lester L

    2014-01-01

    Potential Theory presents a clear path from calculus to classical potential theory and beyond, with the aim of moving the reader into the area of mathematical research as quickly as possible. The subject matter is developed from first principles using only calculus. Commencing with the inverse square law for gravitational and electromagnetic forces and the divergence theorem, the author develops methods for constructing solutions of Laplace's equation on a region with prescribed values on the boundary of the region. The latter half of the book addresses more advanced material aimed at those with the background of a senior undergraduate or beginning graduate course in real analysis. Starting with solutions of the Dirichlet problem subject to mixed boundary conditions on the simplest of regions, methods of morphing such solutions onto solutions of Poisson's equation on more general regions are developed using diffeomorphisms and the Perron-Wiener-Brelot method, culminating in application to Brownian motion. In ...

  3. Belle-II Experiment Network Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Asner, David [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Bell, Greg [ESnet; Carlson, Tim [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Cowley, David [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Dart, Eli [ESnet; Erwin, Brock [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Godang, Romulus [Univ. of South Alabama, Mobile, AL (United States); Hara, Takanori [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Johnson, Jerry [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Johnson, Ron [Univ. of Washington, Seattle, WA (United States); Johnston, Bill [ESnet; Dam, Kerstin Kleese-van [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Kaneko, Toshiaki [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Kubota, Yoshihiro [NII; Kuhr, Thomas [Karlsruhe Inst. of Technology (KIT) (Germany); McCoy, John [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Miyake, Hideki [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Monga, Inder [ESnet; Nakamura, Motonori [NII; Piilonen, Leo [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Pordes, Ruth [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Ray, Douglas [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Russell, Richard [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Schram, Malachi [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Schroeder, Jim [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Sevior, Martin [Univ. of Melbourne (Australia); Singh, Surya [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Suzuki, Soh [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Sasaki, Takashi [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Williams, Jim [Indiana Univ., Bloomington, IN (United States)

    2013-05-28

    The Belle experiment, part of a broad-based search for new physics, is a collaboration of ~400 physicists from 55 institutions across four continents. The Belle detector is located at the KEKB accelerator in Tsukuba, Japan. The Belle detector was operated at the asymmetric electron-positron collider KEKB from 1999-2010. The detector accumulated more than 1 ab-1 of integrated luminosity, corresponding to more than 2 PB of data near 10 GeV center-of-mass energy. Recently, KEK has initiated a $400 million accelerator upgrade to be called SuperKEKB, designed to produce instantaneous and integrated luminosity two orders of magnitude greater than KEKB. The new international collaboration at SuperKEKB is called Belle II. The first data from Belle II/SuperKEKB is expected in 2015. In October 2012, senior members of the Belle-II collaboration gathered at PNNL to discuss the computing and neworking requirements of the Belle-II experiment with ESnet staff and other computing and networking experts. The day-and-a-half-long workshop characterized the instruments and facilities used in the experiment, the process of science for Belle-II, and the computing and networking equipment and configuration requirements to realize the full scientific potential of the collaboration's work.

  4. Centrifuge workers study. Phase II, completion report

    International Nuclear Information System (INIS)

    Wooten, H.D.

    1994-09-01

    Phase II of the Centrifuge Workers Study was a follow-up to the Phase I efforts. The Phase I results had indicated a higher risk than expected among centrifuge workers for developing bladder cancer when compared with the risk in the general population for developing this same type of cancer. However, no specific agent could be identified as the causative agent for these bladder cancers. As the Phase II Report states, Phase I had been limited to workers who had the greatest potential for exposure to substances used in the centrifuge process. Phase II was designed to expand the survey to evaluate the health of all employees who had ever worked in Centrifuge Program Departments 1330-1339 but who had not been interviewed in Phase I. Employees in analytical laboratories and maintenance departments who provided support services for the Centrifuge Program were also included in Phase II. In December 1989, the Oak Ridge Associated Universities (ORAU), now known as Oak Ridge Institute for Science and Education (ORISE), was contracted to conduct a follow-up study (Phase II). Phase H of the Centrifuge Workers Study expanded the survey to include all former centrifuge workers who were not included in Phase I. ORISE was chosen because they had performed the Phase I tasks and summarized the corresponding survey data therefrom

  5. Centrifuge workers study. Phase II, completion report

    Energy Technology Data Exchange (ETDEWEB)

    Wooten, H.D.

    1994-09-01

    Phase II of the Centrifuge Workers Study was a follow-up to the Phase I efforts. The Phase I results had indicated a higher risk than expected among centrifuge workers for developing bladder cancer when compared with the risk in the general population for developing this same type of cancer. However, no specific agent could be identified as the causative agent for these bladder cancers. As the Phase II Report states, Phase I had been limited to workers who had the greatest potential for exposure to substances used in the centrifuge process. Phase II was designed to expand the survey to evaluate the health of all employees who had ever worked in Centrifuge Program Departments 1330-1339 but who had not been interviewed in Phase I. Employees in analytical laboratories and maintenance departments who provided support services for the Centrifuge Program were also included in Phase II. In December 1989, the Oak Ridge Associated Universities (ORAU), now known as Oak Ridge Institute for Science and Education (ORISE), was contracted to conduct a follow-up study (Phase II). Phase H of the Centrifuge Workers Study expanded the survey to include all former centrifuge workers who were not included in Phase I. ORISE was chosen because they had performed the Phase I tasks and summarized the corresponding survey data therefrom.

  6. Removal of Hg(II and Cd(II Ions from Aqueous Solution Using Chitosan: Kinetics and Equilibrium Studies

    Directory of Open Access Journals (Sweden)

    Soheil Sobhanardakani

    2015-05-01

    Full Text Available Background and purpose: The discharge of toxic heavy metal ions into the environment is a serious pollution problem. Heavy metal ions pose adverse toxic risks to human health at very low concentrations. The aim of this paper is the adsorption potential of chitosan (CS in the removal of Hg(II and Cd(II ions from aqueous solution. Materials and Methods: This study was conducted in laboratory scale. In this research, CS was used as an adsorbent for the removal of Hg(II and Cd(II from aqueous solutions. In batch tests, the effects of various parameters such as metals concentration (40-350 mg/L, pH solution (2-8, contact time (5-120 min, and adsorbent dose (0.25-2 g were investigated. Results: The results showed that adsorption of Hg(II and Cd(II ions on CS strongly depends on pH. The experimental data were analyzed using the Langmuir and Freundlich isotherm models. Equilibrium data fitted well with the Langmuir model and the maximum adsorption capacity of the CS for Hg(II and Cd(II were 52.63 and 58.8 mg/g, respectively. Kinetic analysis showed that adsorption was most accurately represented by a pseudo-second-order model. Conclusion: The obtained results showed that CS is a readily, available, economic adsorbent and was found suitable for removing Hg(II and Cd(II ions from aqueous solution.

  7. Structural information on the coordination compounds formed by manganese(II), cobalt(II), nickel(II), zinc(II), cadmium(II) and mercury(II) thiocyanates with 4-cyanopyridine N-oxide from their magnetic moments, electronic and infrared spectra

    Science.gov (United States)

    Ahuja, I. S.; Yadava, C. L.; Singh, Raghuvir

    1982-05-01

    Coordination compounds formed by the interaction of 4-cyanopyridine. N-oxide (4-CPO), a potentially bidentate ligand, with manganese(II), cobalt(II), nickel(II), zinc(II), cadmium(II) and rnercury(II) thiocyanates have been prepared and characterized from their elemental analyses, magnetic susceptibilities, electronic and infrared spectral studies down to 200 cm -1 in the solid state. The compounds isolated are: Mn(4-CPO) 2(NCS) 2, Co(4-CPO) 2(NCS) 2,Ni(4-CPO) 2(NCS) 2,Zn(4-CPO) 2(NCS) 2, Cd(4-CPO)(NCS) 2 and Hg(4-CPO) 2(SCN) 2. It is shown that 4-CPO acts as a terminal N-oxide oxygen bonded monodentate ligand in all the metal(II) thiocyanate complexes studied. Tentative stereochemistries of the complexes in the solid state are discussed. The ligand field parameters 10 Dq, B, β and λ calculated for the manganese(II), cobalt(II) and nickel(II) complexes are consistent with their proposed stereochemistries.

  8. Cd(II and Pb(II complexes of the polyether ionophorous antibiotic salinomycin

    Directory of Open Access Journals (Sweden)

    Tanabe Makoto

    2011-09-01

    Full Text Available Abstract Background The natural polyether ionophorous antibiotics are used for the treatment of coccidiosis in poultry and ruminants. They are effective agents against infections caused by Gram-positive microorganisms. On the other hand, it was found that some of these compounds selectively bind lead(II ions in in vivo experiments, despite so far no Pb(II-containing compounds of defined composition have been isolated and characterized. To assess the potential of polyether ionophores as possible antidotes in the agriculture, a detailed study on their in vitro complexation with toxic metal ions is required. In the present paper we report for the first time the preparation and the structure elucidation of salinomycin complexes with ions of cadmium(II and lead(II. Results New metal(II complexes of the polyether ionophorous antibiotic salinomycin with Cd(II and Pb(II ions were prepared and structurally characterized by IR, FAB-MS and NMR techniques. The spectroscopic information and elemental analysis data reveal that sodium salinomycin (SalNa undergoes a reaction with heavy metal(II ions to form [Cd(Sal2(H2O2] (1 and [Pb(Sal(NO3] (2, respectively. Abstraction of sodium ions from the cavity of the antibiotic is occurring during the complexation reaction. Salinomycin coordinates with cadmium(II ions as a bidentate monoanionic ligand through the deprotonated carboxylic moiety and one of the hydroxyl groups to yield 1. Two salinomycin anions occupy the equatorial plane of the Cd(II center, while two water molecules take the axial positions of the inner coordination sphere of the metal(II cation. Complex 2 consists of monoanionic salinomycin acting in polydentate coordination mode in a molar ratio of 1: 1 to the metal ion with one nitrate ion for charge compensation. Conclusion The formation of the salinomycin heavy metal(II complexes indicates a possible antidote activity of the ligand in case of chronic/acute intoxications likely to occur in the stock

  9. Kinetic study on adsorption of Cr(VI), Ni(II), Cd(II) and Pb(II) ions from aqueous solutions using activated carbon prepared from Cucumis melo peel

    Science.gov (United States)

    Manjuladevi, M.; Anitha, R.; Manonmani, S.

    2018-03-01

    The adsorption of Cr(VI), Ni(II), Cd(II) and Pb(II), ions from aqueous solutions by Cucumis melo peel-activated carbon was investigated under laboratory conditions to assess its potential in removing metal ions. The adsorption behavior of metal ions onto CMAC was analyzed with Elovich, intra-particle diffusion rate equations and pseudo-first-order model. The rate constant of Elovich and intra-particle diffusion on CMAC increased in the sequence of Cr(VI) > Ni(II) > Cd(II) > Pb(II). According to the regression coefficients, it was observed that the kinetic adsorption data can fit better by the pseudo-first-order model compared to the second-order Lagergren's model with R 2 > 0.957. The maximum adsorption of metal ions onto the CMAC was found to be 97.95% for Chromium(VI), 98.78% for Ni(II), 98.55% for Pb(II) and 97.96% for Cd(II) at CMAC dose of 250 mg. The adsorption capacities followed the sequence Ni(II) ≈ Pb(II) > Cr(VI) ≈ Cd(II) and Ni(II) > Pb(II) > Cd(II) > Cr(VI). The optimum adsorption conditions selected were adsorbent dosage of 250 mg, pH of 3.0 for Cr(VI) and 6.0 for Ni(II), Cd(II) and Pb(II), adsorption concentration of 250 mg/L and contact time of 180.

  10. Potential Psychiatric Uses for MDMA

    OpenAIRE

    Yazar?Klosinski, BB; Mithoefer, MC

    2017-01-01

    Phase II trials of 3,4?methylenedioxymethamphetamine (MDMA)?assisted psychotherapy have demonstrated initial safety and efficacy for treatment of posttraumatic stress disorder (PTSD), with potential for expansion to depression and anxiety disorders. In these trials, single doses of MDMA are administered in a model of medication?assisted psychotherapy, differing from trials involving daily drug administration without psychotherapy. This model presents an opportunity to utilize accelerated regu...

  11. and copper(II)

    Indian Academy of Sciences (India)

    Unknown

    that the imidazolate-bridged complex is stable over the pH-range 7⋅15–10⋅0. .... copper(II) complex. The observed room temperature magnetic moments are around. 1⋅79 BM, in agreement with a one-spin (S = 1/2) system. 3.2 EPR studies .... (SK) thanks the Council of Scientific & Industrial Research, New Delhi for an.

  12. Heat transfer II essentials

    CERN Document Server

    REA, The Editors of

    1988-01-01

    REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Heat Transfer II reviews correlations for forced convection, free convection, heat exchangers, radiation heat transfer, and boiling and condensation.

  13. Algebra & trigonometry II essentials

    CERN Document Server

    REA, Editors of

    2012-01-01

    REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Algebra & Trigonometry II includes logarithms, sequences and series, permutations, combinations and probability, vectors, matrices, determinants and systems of equations, mathematica

  14. Transport phenomena II essentials

    CERN Document Server

    REA, The Editors of

    2012-01-01

    REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Transport Phenomena II covers forced convention, temperature distribution, free convection, diffusitivity and the mechanism of mass transfer, convective mass transfer, concentration

  15. EASI graphics - Version II

    International Nuclear Information System (INIS)

    Allensworth, J.A.

    1984-04-01

    EASI (Estimate of Adversary Sequence Interruption) is an analytical technique for measuring the effectiveness of physical protection systems. EASI Graphics is a computer graphics extension of EASI which provides a capability for performing sensitivity and trade-off analyses of the parameters of a physical protection system. This document reports on the implementation of the Version II of EASI Graphics and illustrates its application with some examples. 5 references, 15 figures, 6 tables

  16. Numerical analysis II essentials

    CERN Document Server

    REA, The Editors of; Staff of Research Education Association

    1989-01-01

    REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Numerical Analysis II covers simultaneous linear systems and matrix methods, differential equations, Fourier transformations, partial differential equations, and Monte Carlo methods.

  17. Inhibition of Zn(II binding type IA topoisomerases by organomercury compounds and Hg(II.

    Directory of Open Access Journals (Sweden)

    Bokun Cheng

    Full Text Available Type IA topoisomerase activities are essential for resolving DNA topological barriers via an enzyme-mediated transient single strand DNA break. Accumulation of topoisomerase DNA cleavage product can lead to cell death or genomic rearrangement. Many antibacterial and anticancer drugs act as topoisomerase poison inhibitors that form stabilized ternary complexes with the topoisomerase covalent intermediate, so it is desirable to identify such inhibitors for type IA topoisomerases. Here we report that organomercury compounds were identified during a fluorescence based screening of the NIH diversity set of small molecules for topoisomerase inhibitors that can increase the DNA cleavage product of Yersinia pestis topoisomerase I. Inhibition of relaxation activity and accumulation of DNA cleavage product were confirmed for these organomercury compounds in gel based assays of Escherichia coli topoisomerase I. Hg(II, but not As(III, could also target the cysteines that form the multiple Zn(II binding tetra-cysteine motifs found in the C-terminal domains of these bacterial topoisomerase I for relaxation activity inhibition. Mycobacterium tuberculosis topoisomerase I activity is not sensitive to Hg(II or the organomercury compounds due to the absence of the Zn(II binding cysteines. It is significant that the type IA topoisomerases with Zn(II binding domains can still cleave DNA when interfered by Hg(II or organomercury compounds. The Zn(II binding domains found in human Top3α and Top3β may be potential targets of toxic metals and organometallic complexes, with potential consequence on genomic stability and development.

  18. Cervantes y Felipe II

    Directory of Open Access Journals (Sweden)

    Ludovik Osterc

    1999-12-01

    Full Text Available Como es sabido, el 13 de septiembre de 1598, a las cinco de la mañana, falleció en el Escorial el Rey Felipe II. Sevilla que según sus historiadores siempre se distinguió entre todas las ciudades de España por el fausto y suntuosidad de los sucesos solemnes, ya sea cuando los monarcas se dignaban visitarla, ya sea cuando se trataba de honrar su memoria con ocasión de su muerte, se habia excedido a si misma en el reinado de Felipe II. La pública y señorial entrada de su padre, el emperador Carlos V cuando en 1526 vino a esta ciudad para realizar sus bodas con la Infanta Isabel de Portugal, que por su magnificencia consignan sus anales, como superior a cuantas hubo antes en análogas circunstancias, no puede compararse con el recibimiento dispensado a Felipe II, el año de 1570, que por encargo de su Cabildo describió la docta pluma de Mal Lara.

  19. BeII** revisited

    International Nuclear Information System (INIS)

    Fischer, C.F.

    1982-01-01

    Doubly excited 1s2snl and 1s2pnl quartet states of BeII** are readily populated in beam-foil experiments and line-rich spectra have been obtained covering 600 to 5500 A wavelength range. In spite of several theoretical calculations a substantial number of observed lines have not been identified. The quartet system in BeII is an intersting one from a theoretical point of view. Three electron systems are simple enough that a fairly high level of accuracy is attainable without the calculations becoming horrendous. The important correlation effects are between the outer two electrons and, to a good approximation, the three-electrons system may be treated as a two-electron system outside a 1s-core. The multi-configuration Hartree-Fock (MCHF) method has been used successfully in a number of studies. Programs are under development that take into account the non-orthogonality of orbitals in the initial and final state, and allow for some non-orthogonal orbitals in a wavefunction expansion. LS dependent relativistic effects are also included. A study of BeII** was undertaken to evaluate the MCHF techniques being developed and to assit in the identification of observed lines. Most of the earlier calculations concentrated on the lower-lying levels. In this work particular attention was given to the more highly-excited states, though calculations for lower-lying states had to be repeated in order to predict life-times

  20. What is LAMPF II

    Energy Technology Data Exchange (ETDEWEB)

    Thiessen, H.A.

    1982-08-01

    The present conception of LAMPF II is a high-intensity 16-GeV synchrotron injected by the LAMPF 800-MeV H/sup -/ beam. The proton beam will be used to make secondary beams of neutrinos, muons, pions, kaons, antiprotons, and hyperons more intense than those of any existing or proposed accelerator. For example, by taking maximum advantage of a thick target, modern beam optics, and the LAMPF II proton beam, it will be possible to make a negative muon beam with nearly 100% duty factor and nearly 100 times the flux of the existing Stopped Muon Channel (SMC). Because the unique features of the proposed machine are most applicable to beams of the same momentum as LAMPF (that is, < 2 GeV/c), it may be possible to use most of the experimental areas and some of the auxiliary equipment, including spectrometers, with the new accelerator. The complete facility will provide improved technology for many areas of physics already available at LAMPF and will allow expansion of medium-energy physics to include kaons, antiprotons, and hyperons. When LAMPF II comes on line in 1990 LAMPF will have been operational for 18 years and a major upgrade such as this proposal will be reasonable and prudent.