WorldWideScience

Sample records for solarne zariadenia ako

  1. 7. juunil kaitses Tallinna Ülikoolis oma doktoritööd Ako Sauga

    Index Scriptorium Estoniae

    2006-01-01

    Ako Sauga doktoritöö teema oli "Influence of environmental fluctuations on dynamics of non-linear systems" (pealkiri eesti keeles : "Keskkonnaparameetrite fluktuatsioonide mõju mittelineaarsete süsteemide dünaamikale")

  2. Šach ako metafora matematiky

    Czech Academy of Sciences Publication Activity Database

    Kvasz, Ladislav

    2015-01-01

    Roč. 70, č. 3 (2015), s. 175-187 ISSN 0046-385X Grant - others:AV ČR(CZ) Fellowship J. E. Purkyně Institutional support: RVO:67985955 Keywords : chess * mathematics * philosophy of mathematics Subject RIV: AA - Philosophy ; Religion

  3. Joint research project AkoF. Optimization of the process chain ''ablation of contaminated surfaces'' under the aspect of ablation rate maximization. Final report

    International Nuclear Information System (INIS)

    Hentschel, Sebastian; Gentes, Sascha; Bussmann, Andrea; Boersch, Fabian; Feil, Hartmut

    2014-01-01

    milling machine allows for surface concrete removal of up to 10 mm in one work step. The performance exceeds 1Om 2 /h and water cooling is no longer necessary to prevent foreign contamination. The project scope includes the measuring of operating forces, the construction and mounting of a feasible and flexible carrier system, as well as the development of a remote control unit. Furthermore, the workflow has been adapted (removal, suction, separation, and conditioning) and optimized for this new decontamination method. Main requirements for the carrier system and the decontamination concept are: - Personnel for monitoring and set-up of the devices is limited to two persons - Doors (width 1 m, height 2 m) must be accessible at all times - The device is to be equipped with a suction mechanism - The floor surface load must not exceed 15.000 N/m 2 - Using internal combustion engines is prohibited - The tools are designed for superficial cutting only, not for the demolition of activated or fully contaminated concrete - The tools must work without a water cooling system. The results from practical tests and basic research of both EnBw's NPP in Obrigheim and KIT's Institute for Technology and Management in Construction have been combined and further improved with a specific emphasis on the workflow of ''Cutting Contaminated Surfaces (cooperation project AkoF)'' while, at the same time, maximizing the removal rate of the floor planer. The cutting procedure is to be optimized using existing synergies in order to better compete with conventional technologies.

  4. Franchising ako metóda vstupu na trh

    OpenAIRE

    Koreňová, Hana

    2008-01-01

    My Bachelor thesis analyzes franchising as the method of market entering.The analysis consists of two parts, theoretical and practical. The forms of expansion to the foreign markets are defined, while the accent is put on the franchising. SUBWAY, one of the world's most successful franchise companies, is taken to show how the concept operates. I tried to point out the problems which a young company must face in Czech Republic, find out the strengths and weaknesses of the concept, suggest the ...

  5. SW modul TCP/IP a Modbus pro OS FreeRTOS

    OpenAIRE

    Šťastný, Ladislav

    2012-01-01

    Cieľom tejto práce je zoznámenie sa s operačným systémom FreeRTOS a jeho využitia pri realizácií zariadení. V práci je rovnako rozobraté využitie SW modulu LwIP (TCP/IP stack) a FreeMODBUS. Následne je navrhnuté ukážkové zariadenie, jednoduchý operátorský panel. Ten komunikuje pomocou rozhrania ethernet s využitím protokolu Modbus TCP s pripojenými PLC na separátnej sieti. Úlohou zariadenia je plniť funkciu webserveru, HID a súčasne slúžiť ako zdroj reálneho času. The aim of this work is t...

  6. Koučing ako metóda vzdelávania zamestnancov

    OpenAIRE

    Kolesárová, Ľudmila

    2009-01-01

    The thesis introduces an area of corporate education, conditions of its systematic and efficient management and methods of training employees. The scope of this thesis is to analyze strengths and weaknesses of coaching if used as method of training employees. The analysis is mostly focused on internal coaching, compares advantages and disadvantages of internal coaching towards external and also focuses on coaching in general as a method used for training employees.

  7. Zákaznícky servis ako nástroj CRM

    OpenAIRE

    Smiková, Lenka

    2009-01-01

    The bachelor thesis analyzes and assesses the marketing mix of Prague City Apartments, s.r.o. It is focused on functioning of customer service as a part of the concept of Customer Relationship Management (CRM). The analysis is based on theoretical knowledge of marketing of services and CRM and on the importance of customer service in rendition of services, particularly in tourism and hotel industry. The thesis provides, via SWOT analysis, suggestions for improving quality of customer service ...

  8. Popieranie holokaustu ako spoločenský fenomén

    OpenAIRE

    Moravská, Dorota Tabitha

    2011-01-01

    The work deals with Holocaust denial as a social phenomenon that is considered to be a form of anti-Semitism. It describes the roots of Holocaust denial in Europe and in the USA and its subsequent extension in other parts of the world, focusing especially on Arabic/ Muslim countries where this phenomenon represents part of the official propaganda and constitutes and active element of Israeli-Palestinian conflict. The thesis then depicts the methodology of Holocaust denial which leads to the t...

  9. Što ako androidi zaista sanjaju električne ovce?

    OpenAIRE

    Grgić, Lovro

    2009-01-01

    U ovom radu pokušao sam ispitati implikacije koje bi znanstveno tehnička postignuća na području robotike, po nekima dohvatljiva u skoroj budućnosti, mogla imati na status robota i međuodnos robota i ljudi. Osnovna pitanja koja se u tekstu obrađuju su sljedeća: Što je dovoljno da se neko biće smatra živim? Koja prava proizlaze iz takvog statusa? Koji su preduvjeti da živo biće bude i moralno biće? Je li moguće da robot bude moralno biće? Kakav status zaslužuju bića s moralnim potencijalom? U s...

  10. KOGNITÍVNE SKRESLENIA AKO SÚČASŤ SPRISAHANECKÝCH TEÓRIÍ

    Directory of Open Access Journals (Sweden)

    Imrich Ruisel

    2015-09-01

    Full Text Available The beginnings of modern Greek philosophy have already indicated that man is not a reliable information processor, because he is unable to completely encompass the real world at a cognitive level. Thus, already Plato distinguished between the knowledge of the real true belief (epistémé and opinion (doxa. F. Bacon assumed that human senses are not the measure of reality. Psychologists A. Tversky and D. Kahneman pointed out that people do not follow rational arguments and set rules in their judgments. Rather, they use heuristics, which are simplified judgment rules that enable quick judgments, often biased by individual’s subjective beliefs. These wrong conclusions induce false ideas or fallacies. There are deductive and inductive fallacies. We contemplate the ratio of cognitive fallacies in forming and existence of conspiracy theories. Deliberate use of fallacies and biases is characteristic of the use of conspiracy theories in propaganda. Wrong judgments are made due to wrong understanding of coincidental events, insufficient processing of the laws of statistical regression and the tendency to search for confirmation. Preferred are verbal techniques in the form of naive and ritualized terms and statements based on unidentifiable fallacies.

  11. Vodcovstvo ako úspešný predpoklad pre dosahovanie zvyšovania konkurenčnej schopnosti podnikov

    OpenAIRE

    Hudakova, Ivana

    2008-01-01

    The idea of leadership has fascinated people for centuries. Leadership, or leading, is an asocial process, where the leader is seeking for voluntary participation of the subordinated, thus striving to achieve the company's objectives. Leadership clearly proves to be more than exercising power and authority. It also covers a number of managerial abilities, such as susceptibility, motivation, scrupulousness, empathy and communication. Leadership has to be present at all levels of the organizati...

  12. Peniaze ako zdroj šťastia v našich životoch? (Is Money a Source of Happiness in our lives?

    Directory of Open Access Journals (Sweden)

    Otakar Horák

    2013-06-01

    Full Text Available This paper begins by referring to the research which distinguishes two different aspects of subjective well-being, namely 1. experiences of happiness – measured by frequency and intensity of joy, stress, anger, worry and sadness we experience at a certain moment and 2. life satisfaction. Survey shows that beyond an annual household income of $75 000 there is no increase in the experiences of happiness. The paper then refers to the psychological mechanisms and factors – namely hedonic adaptation, social comparison and stress as a result of a raise – that lower the capacity of money to buy us the experiences of happiness. Not only we get quickly used to the things we buy, money also puts us into stressful situations and makes us build barriers between people. The paper then specifies strategies of economic decision-making that contribute to the maximization of happiness, such as purchase of the experiences instead of the things, interrupted and postponed consumption, or prosocial spending. The research indicates that prosocial spending has higher causal impact on promoting happiness than personal spending. As a matter of fact, this phenomenon is not culturally limited to the West. Concluding assertion – expressed only in the form of hypothesis – says that prosocial spending which is a form of prosocial behavior strengthens – through production of happiness – mutual relations in the society (cooperation.

  13. 'Jeden vel'ký kolektív': Folklór ako vystúpenie a organizácia

    Czech Academy of Sciences Publication Activity Database

    Feinberg, Joseph Grim

    2016-01-01

    Roč. 48, č. 4 (2016), s. 357-376 ISSN 0049-1225 Institutional support: RVO:67985955 Keywords : folklore * performativity * public sphere and privacy * aesthetic theory * social theory Subject RIV: AO - Sociology, Demography Impact factor: 0.283, year: 2016

  14. Smiech ako moc a premeny človeka súčasnosti (The Laughter as a Power and Changes of Contemporary Human

    Directory of Open Access Journals (Sweden)

    Romana Javorčeková

    2016-03-01

    Full Text Available This article deals with the power of laugh as an expression of a human evoked by emotional, cognitive, physiological, and expressive changes which cause further changes in another person and society. Ambivalence is one of the basic characteristics of laugh which is why it cannot be fullly grasped in theory, even though it has been proved that joy expressed by laugh is the most universal emotion. Examples from movies serve well to observe laugh as a form of social gesture in contemporary society.

  15. Včelí jed ako zdroj antimikrobiálnych peptidov: Štúdium mechanizmu účinku

    Czech Academy of Sciences Publication Activity Database

    Čujová, Sabína; Čeřovský, Václav

    2014-01-01

    Roč. 108, č. 5 (2014), s. 527 ISSN 0009-2770. [Mezioborové setkání mladých biologů, biochemiků a chemiků /14./. 13.05.2014-16.05.2014, Milovy] Institutional support: RVO:61388963 Keywords : antimicrobial peptides * tryptophan fluorescence * calcein leakage Subject RIV: CC - Organic Chemistry

  16. Sociálny kapitál ako prevencia negatívnej agresivity adolescentov ( Social Capital as a Prevention of Adolescents’ Aggressive Behaviours

    Directory of Open Access Journals (Sweden)

    Andrea Božeková

    2014-12-01

    Full Text Available Aggression as undesirable risk behaviour is a serious social problem which requires effective prevention and intervention solutions. This paper focuses on concept of Social Capital as an important factor in reduction of aggressive behaviour in family, school and neighbourhood. Relationships amongst family members, the involvement of parents in school activities, the participation of young people at school events and hobby groups and the activities of local youth and religious institutions can be identified as relevant components of social capital decreasing juvenile aggression. Positive social relationships offer an adequate prevention of adolescent aggression but also facilitate the inclusion of young people (who during adolescence and “dramatic clashes” create their personal identity, ultimately determining their life as adults into society.

  17. Priateľstvo ako cnosť súkromná i verejná (Friendship as a Private and Public Virtues

    Directory of Open Access Journals (Sweden)

    Matúš Porubjak

    2008-03-01

    Full Text Available The aim of this article is to show a social role of friendship (filia in Classical Greece and to discover why, as Aristotle thinks, is filia the greatest good for the polis. The author bases his analysis on a comparison between Plato’s dialogue Lysis and Aristotle’s Politics (namely the book 1 and book 3. He distinguishes four types of filia, and shows the social role played by each one of them: the love of parents to children, the friendship between teenage boys of the same age, the love of elder men to boys, and the friendship between free adult citizens.

  18. Stropná erózia v jaskyniach: počiatky skúmania a Zdeněk Roth ako autor konceptu

    Czech Academy of Sciences Publication Activity Database

    Bella, P.; Bosák, Pavel

    2013-01-01

    Roč. 18, č. 2 (2013), s. 84-86 ISSN 1335-213X Institutional support: RVO:67985831 Keywords : ceiling channel * paragenesis * antigravitative erosion * definition * Zdeněk Roth * Domica Cave * Slovak Karst Subject RIV: DB - Geology ; Mineralogy

  19. Ekonomika inovácie ako súčasť zvyšovania výkonnosti firmy

    Directory of Open Access Journals (Sweden)

    Chromjaková Felicita

    2009-12-01

    Full Text Available Základom dobre nastavenej inovácie je jej správna ekonomika, teda znalosť prietoku hodnoty, participujúcej v rôznych etapách na tvorbe inovácií a komplexnom inovačnom procese firmy. Prietok hodnoty má zásadný význam pre ekonomiku inovácie v tom, že na základe optimálne definovaných inovačných metrík dokáže identifikovať reálne ekonomické vstupy a výstupy a priamo poukázať na inovačný potenciál firmy a jeho úspešnosť z hľadiska zvyšovania budúcej výkonnosti firmy.The basis of a well balanced innovation is its right economy, that is so the knowledge of the value throughput, participating in the various phases of creating the innovation and of a complex innovation process of the company. Value throughput has an essential importance for the innovation economy there, where on the basis of optimally defined innovation metrics can be identified real economical inputs and outputs and directly the innovation potential of the ompany and its success from the point of view of the increase of its future efficiency.

  20. Povaha ľudskej spolupráce a význam altruistického trestania: Ako sa ľudia správajú v laboratóriu a v teréne?

    Directory of Open Access Journals (Sweden)

    Martin Hulín

    2014-03-01

    Full Text Available There is an increasing interest of behavioral economists in the last decades in studying the nature of human cooperation and morality. Several economic games of social dilemmas have been developed to this end. Based on the results of these games, important conclusions are made about human cooperation. Since people in these games all over the world do not behave completely selfishly and give away money, it is taken as demonstrating other important motivations. When people are given the opportunity to punish free-riders, this increases cooperation, which is again interpreted in the sense of altruistic punishment (strong reciprocity that is considered a key factor in sustaining cooperation. However, these results are in contrast with the anthropological literature on hunter-gatherers’ cooperation, which highlights other important factors sustaining cooperation, such as the possibility to choose partners, and symbolic and coalitional sanctions (weak reciprocity. The aim of the research is to critically analyze these contrasts and illustrate some aspects of cooperation (conflict resolution, dealing with cheaters, and the role of reputation from the author’s own research of mutual aid among peasants in Serbia.

  1. Regionálne povedomie a identita regiónu ako premenné v rámci procesu inštitucionalizácie regiónu

    Czech Academy of Sciences Publication Activity Database

    Nikischer, Richard

    2014-01-01

    Roč. 13, č. 3 (2014), s. 83-91 ISSN 1336-2232. [Geografia a integrovaný výskum krajiny. Ružomberok, 10.09.2013-12.09.2013] R&D Projects: GA MŠk(CZ) LG12023 Institutional support: RVO:68378025 Keywords : institutionalization of the region * regional consciousness * identity of the region

  2. Segmentácia trhu pri použití marketingových dát ako súčasť marketingovej stratégie

    OpenAIRE

    Nagyová-Tkáčová, Monika

    2013-01-01

    The thesis deals mainly with market segmentation which is very important part of marketing strategy. The theoretical part consists of general knowledge of marketing, a Customer relationship management (CRM), market segmentation and database marketing. A case study consists of the implementation of the theoretical knowledge into the practical part. The aims of the thesis are: an introduction to the issue of market segmentation, an importance of market segmentation in creating marketing strateg...

  3. Vernostné programy v leteckej spoločnosti ako nástroj riadenia vzťahov so zákazníkmi

    OpenAIRE

    Demčáková, Vanda

    2015-01-01

    This bachelors thesis Loyalty programs as a CRM tool used by airline describes the importance of Customer Relationship Management in todays competitive market and explains basic concepts of a relationship between organization and customers, such as customer value, satisfaction and loyalty. In the practical part is the knowledge from theoretical part applied on the specific airline. The practical part presents an assessment and evaluation of the loyalty program OK Plus Partner. To carry out th...

  4. Podnikové výdavky na výskum a vývoj ako súčasť inovačnej kapacity v podmienkach konkurujúcich si odvetví

    Directory of Open Access Journals (Sweden)

    Martina Prochádzková

    2013-10-01

    Full Text Available Purpose of the article: This paper examines how firms ‘internal factors and their industrial affiliation influence the amount of business expenditures on research and development. Methodology/methods: The means for expressing that relation is the hierarchical linear model, in which the fixed explanatory variables are quantitative business indicators that include the number of employees, operational profit and capital expenditures. The qualitative explanatory factor is the industry, in which the firm operates. Scientific aim: The paper sees business expenditures on research and development as one of the factors that determine the firms innovative performance, which in turn may contribute to the growth of the country’s innovative capacity. Data of 1410 firms were used, classified into groups according to their country of operation. The industrial factor of investment in research and development is also examined. Findings: The results show, that there exists a strong influence of expenditures on research and development, while the influence of the number of employees is not statistically significant. Conclusions: The findings also suggest that although some industries, such as manufacturing or production and distribution of electricity, were expected to have high expenditures on research and development, in fact, they are lower than the average. According to EU Industrial R&D Investment Scoreboard, the best innovative performance is shown by the pharmaceutical sectors, which is the top R&D investor, too. The paper shows, that the highest expenditures on research and development are realized by software sector, pharmaceutical sector, telecommunications equipment, biotechnology and semiconductors. On the other hand, the lowest expenditures are in automobile and parts and technology hardware and equipment sectors.

  5. Selektívny mutizmus ako úzkostná porucha? Stručný prehľad o etiológii selektívneho mutizmu

    OpenAIRE

    Gabriela Majerechová

    2015-01-01

    Selective mutism is a disorder in which a child fluently speaks in well-known situations but is mute in less known situations. Despite overall etiology research, causes of mutism are still unrevealed. The paper summarizes various research studies which focused on links between selective mutism and anxiety disorders, particularly social phobia. In spite of some empirical evidence, it is still impossible to state that the selective mutism is an anxiety disorder.

  6. PRIPRAVA IN KARAKTERIZACIJA NANOKRISTALINIČNIH TERNARNIH KADMIJEVIH HALKOGENIDOV

    OpenAIRE

    Denac, Boštjan

    2014-01-01

    Polprevodni materiali kot CdSe, CdTe, in CdSexTe1-x so osnova modernih elektronskih naprav. Znano je, da se polprevodni teluridi uporabljajo za senzorje, laserje, optične filtre, solarne celice in za mnoge druge naprave. Prav tako obetajoča za uporabo v solarnih celicah, fotoprevodnikih in tankoplastnih tranzistorih je mešanica binarnih halkogenidov s sestavo CdSexTe1-x. Ternarni kadmijevi halkogenidi so bili pripravljeni z uporabo različnih sinteznih metod: hidrotermalno, z mikrovalovi i...

  7. The annual school reports as artefacts of book culture and sources on the history of Jewish education in Slovakia (Výročné správy škôl ako artefakty knižnej kultúry a pramene k dejinám židovského školstva na Slovensku

    Directory of Open Access Journals (Sweden)

    Kamila Fircáková

    2016-09-01

    Full Text Available This paper outlines the history of the annual school reports publishing on the terri-tory of Slovakia. It also provides the basic bibliographic sources in which the annual school reports are registered. The annual school reports began to be systematically published in the second half of the 19th century. Also the Jewish schools, which history is much older (e. g. a school existed at the synagogue in Bratislava as early as 1416 published them. During the extensive research in libraries in Slovakias well as 21 titles of the annual school reports of some Jewish schools published in Slovakia until 1918 were found. The annual school reports of the primary schools, business schools, religious schools (the so-called talmudtóra, boys‘ schools, girls‘ schools and co-educational schools are among them. The content of the annual school reports of Jewish schools is presented in the example of the annual school report of the boys‘ public school associated with the business school in Bratislava and public school in Liptovsky Mikulas. As artefacts of book culture they are an especially a rich source of information about a particular school, they document publishing activities of a school or its founders and complete the knowledge about production of individual printers and printing houses. Through the ownership stamps and records they provide information about previous owners and assist in the reconstruction of the library stocks. At the moment known annual school reports of Jewish schools are certainly only a part of a larger, not yet fully discovered corpus (e. g. we can assume the existence of the annual school reports of the higher schools - yeshivas in Hebrew. Their systematic research, documentation and expert processing should become part of research and protection of Jewish cultural heritage in Slovakia.

  8. Auxínom indukovaná špecifická degradácia proteínov v cicavčích bunkách ako experimentálny nástroj pre štúdium funkcie proteínov

    Czech Academy of Sciences Publication Activity Database

    Ferencová, Ivana; Šolc, Petr

    2017-01-01

    Roč. 27, č. 4 (2017), s. 104-107 ISSN 1210-1737 R&D Projects: GA MŠk(CZ) LO1609 Institutional support: RVO:67985904 Keywords : auxin * protein degradation * protein function determination Subject RIV: EA - Cell Biology OBOR OECD: Cell biology

  9. Platón ako Pseudo-Sókratés? Niekoľko poznámok k problematike autorstva filozofického textu v antike ( “Plato as Pseudo-Socrates? Some Remarks on the Problems Related to the Autorship of a Philosophical Text in Antiquity“

    Directory of Open Access Journals (Sweden)

    František Škvrnda ml.

    2017-12-01

    Full Text Available The following paper deals with the problematic category of authorship in ancient philosophical literature. Philosophers are divided into two groups: the first consist of non-writing protagonists (e. g. Socrates, Ammonius of Saccas, while the second category includes writing authors (e. g. Plato, Aristotle. Paper argues that with regard to their „historicity“, between these two groups of philosophers is no substantial difference. Philosophical texts were often written in co-authorship. Many students and later adherents passed their own doctrines off as teacherʼs originals. Moreover, due to the fact that the very texts were transcribed countless times, there is no certainty about original phrasing of the documents that came down to our modern or renaissance era. The „historicity“ of philosophersʼ attitudes and ideas therefore can not be deduced from the existence of authorized text, written by some particular author.

  10. Nigerian Hospital Practice - Vol 15, No 1-3 (2015)

    African Journals Online (AJOL)

    Therapeutic Efficacy of Intermittent Cryotherapy in the Management of Closed Soft Tissue Injuries · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. AKO Henry, K Amadi, BG Ogundumade, 10-13 ...

  11. Jens Beckert, 2016, Fraud and Fantasy

    DEFF Research Database (Denmark)

    Harrington, Brooke

    2017-01-01

    Contribution to review symposium on: Jens Beckert (2016): Imagined Futures. Fictional Expectations and Capitalist Dynamics. Harvard University Press. Other ontributions from: Akos Rona-Tas (University of California, San Diego) ; William Deringer (Massachusetts Institute of Technology) and Jenny A...

  12. From Commonwealth to Postcolonial Literature

    OpenAIRE

    Ako, Edward O.

    2004-01-01

    In his paper,"From Commonwealth to Postcolonial Literature," Edward O.Ako begins by establishing the link between Empire and English-language literature. Drawing on Elleke Boehmer, Gauri Viswanath, and Terry Eagleton, Ako discusses the ideological uses of literature and argues that the textual forms that emerged as "resistance" to imperial domination were referred to by a multiplicity of terms: Commonwealth Literature, New English Literature, Literature in English, Third World Literature, Wor...

  13. Rozprávka ako nástroj spoločenskej satiry vo francúzskej literatúre 18. storočia: Charles Duclos a jeho Acajou a Zirphile (1744 (Le conte comme l’outil de la satire sociale dans la littérature française du XVIIIe siècle : Charles Duclos et son Acajou et Zirphile (1744

    Directory of Open Access Journals (Sweden)

    Andrea Tureková

    2012-12-01

    Full Text Available Le présent article est consacré à la problématique du conte libertin du XVIIIe siècle et plus particulièrement à sa dimension satirique à l’égard de la société contemporaine. Sur l’exemple du conte de Charles Duclos, Acajou et Zirphile (1744, l’auteur analyse les différentes facettes que prend la satire sociale dans ce conte, qui se veut une « sottise ».

  14. Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration.

    Science.gov (United States)

    Hatazawa, Yukino; Ono, Yusuke; Hirose, Yuma; Kanai, Sayaka; Fujii, Nobuharu L; Machida, Shuichi; Nishino, Ichizo; Shimizu, Takahiko; Okano, Masaki; Kamei, Yasutomi; Ogawa, Yoshihiro

    2018-03-01

    DNA methylation is an epigenetic mechanism regulating gene expression. In this study, we observed that DNA methyltransferase 3a (Dnmt3a) expression is decreased after muscle atrophy. We made skeletal muscle-specific Dnmt3a-knockout (Dnmt3a-KO) mice. The regeneration capacity after muscle injury was markedly decreased in Dnmt3a-KO mice. Diminished mRNA and protein expression of Dnmt3a were observed in skeletal muscles as well as in satellite cells, which are important for muscle regeneration, in Dnmt3a-KO mice. Dnmt3a-KO satellite cell showed smaller in size (length/area), suggesting suppressed myotube differentiation. Microarray analysis of satellite cells showed that expression of growth differentiation factor 5 (Gdf5) mRNA was markedly increased in Dnmt3a-KO mice. The DNA methylation level of the Gdf5 promoter was markedly decreased in Dnmt3a-KO satellite cells. In addition, DNA methylation inhibitor azacytidine treatment increased Gdf5 expression in wild-type satellite cells, suggesting Gdf5 expression is regulated by DNA methylation. Also, we observed increased inhibitor of differentiation (a target of Gdf5) mRNA expression in Dnmt3a-KO satellite cells. Thus, Dnmt3a appears to regulate satellite cell differentiation via DNA methylation. This mechanism may play a role in the decreased regeneration capacity during atrophy such as in aged sarcopenia.-Hatazawa, Y., Ono, Y., Hirose, Y., Kanai, S., Fujii, N. L., Machida, S., Nishino, I., Shimizu, T., Okano, M., Kamei, Y., Ogawa, Y. Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration.

  15. Osamitev in identifikacija gliv iz grenčice Sečoveljskih solin

    OpenAIRE

    Logar, Elinda

    2017-01-01

    Sečoveljske soline štejemo med solarne soline, za katere je značilno izparevanje morske vode v zaporednih plitkih umetno ustvarjenih bazenih v namen pridobivanja halita (NaCl). Ko se ga večina obori, ostane matična lužina oz. grenčica, ki je bogata z drugimi solmi, kot sta MgCl2 in MgSO4. Raziskovalci so v zadnjih 15 letih iz slanice solin osamili in okarakterizirali številne vrste gliv. Malo pa je znanega o njihovem življenju v vodi po evaporaciji halita,v grenčici, kar je bil cilj naše razi...

  16. Apartmánový hotel - stavebně technologický projekt

    OpenAIRE

    Srna, Michal

    2013-01-01

    Diplomová práca sa zaoberá stavebne technologickým projektom apartmánového hotela v Tatranskej Štrbe. Projekt rieši prípravu časových, finančných materiálových a iných zdrojov. Súčasťou práce je rozpočet, prepočet, časový plán, návrh hlavných mechanizmov, kontrolné a skúšobné plány, technologický predpis, zariadenia staveniska, štúdie realizácie hlavných technologických etáp a porovnanie murovacích systémov. This master thesis deals with construction-technological project of apartment hote...

  17. Návrh a realizace aircraft interface device

    OpenAIRE

    Jankech, Tomáš

    2015-01-01

    Cieľom diplomovej práce je návrh a realizácia rozhrania leteckých zberníc. Práca rozoberá problematiku zariadení Aircraft Interface Device a popisuje najpoužívanejšie typy avonických zberníc. Zaoberá sa teoretickým návrhom dizajnu modulu PCI/104–Express. Pri návrhu sa využíva modularita pre dosiahnutie maximálnej konfigurovateľnosti zariadenia. Práca ďalej približuje výber vhodných komponentov a ich použitie vo výslednom návrhu. Posledná časť popisuje architektúru firmware. The aim of this...

  18. Testování komunikace ochran podle IEC 61850

    OpenAIRE

    Bolgár, Robert

    2011-01-01

    Cieľom práce je praktické použitie normy IEC 61850, ktorá sa zaoberá komunikáciou zariadení v rozvodni ale aj mimo ňu. Hlavná myšlienka je v návrhu modelu, ktorý bude slúžiť pre testovanie komunikácie medzi ochranami za pomoci testovacieho zariadenia CMC 256plus od firmy OMICRON a jeho softvérového vybavenia „IEDScout“, „GOOSE Configuration“ a „QuickCMC“. Goal of this thesis is practical use of standard IEC 61850, which deals with communication between devices in substation. The main idea ...

  19. Ühepäevaliblika lend üle valgete laikude / Sven Karja

    Index Scriptorium Estoniae

    Karja, Sven, 1968-

    2000-01-01

    Teatrikriitika olukorrast - kiirtempo, esietenduse põhjal arvustamine, väikelinnateatrite keskmised lavastused jäävad kajastuseta. Vaadeldakse hooaja kolme "mahavaikitud " lavastust - Akos Kertészi "Lesed" Eili Neuhausi lavastuses Rakvere Teatris, Mario Fratti "Ohver" Madis Kalmeti lavastuses Pärnu Endlas ja David Williamsoni "Sõbrad ja raha" Viljandi Ugalas.

  20. Clinics in Mother and Child Health - Vol 3, No 2 (2006)

    African Journals Online (AJOL)

    Le devenir materno-foetal chez les femmes eclamptiques accouchees par cesarienne ou par voie basse des trois hopitauxt tertiaires a yaounde. R E Mbu, Dempouo, P N Nana, R N Tonye, S Ako, N T Eteki, R I Leke ...

  1. International Journal of Biological and Chemical Sciences - Vol 3 ...

    African Journals Online (AJOL)

    La production du miel à Manigri (Commune de Bassila) au Bénin: enjeu et importance socio-économique · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. H Yédomonhan, A Akoègninou. http://dx.doi.org/10.4314/ijbcs.v3i1.42743 ...

  2. Journal de la Recherche Scientifique de l'Université de Lomé - Vol 8 ...

    African Journals Online (AJOL)

    Potentialités de production de miel de la forêt classée de la lama (Bénin) · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. H Yédomonhan, A Akoègninou, GM Tossou, K Akpagana ...

  3. A South African Perspective

    African Journals Online (AJOL)

    25681966

    of culture within development discourse. Attempts at linking culture to development are often limited to mainstreaming investments in cultural heritage and the living arts. This is probably why Hawkes. 38. Ako "Challenges to Sustainable Development" 11. 39. In 1952, cultural anthropologists, Kroeber and Kluckhohn Culture, ...

  4. The Promotion of Teaching Excellence in Higher Education: A Comparison of the Australian and New Zealand Approaches

    Science.gov (United States)

    Abbott, Malcolm

    2012-01-01

    In this paper a comparison is made between the structure and operations of the Australian Learning and Teaching Council and the Ako Aotearoa National Centre for Tertiary Teaching Excellence of New Zealand. Both of these organisations were established in the mid 2000s and were created at a time when higher education institutions in both countries…

  5. 2551-IJBCS-Article-Innocent D Y Ahemidé

    African Journals Online (AJOL)

    hp

    l'asthme, la migraine et l'ictère (Akoègninou et al., 2006; Esimone et al., 2007). Sur le plan ..... 20Pdf/2013/October/101013896%20Eda gbo%20et20al.pdf. Ekhaise OF, Agboh MK, Uanseoje S. 2010. Evaluation of the Methanolic Extract of. Mistletoe (Tapinanthus bangwensis). Leaves Grown on Orange Trees for the.

  6. Agencijski posao - prikriveni : (prikaz presude

    Directory of Open Access Journals (Sweden)

    Vesna Skorupan Wolff

    2013-12-01

    Full Text Available Pomorski agent nastupa u ime i za račun nalogodavatelja. Ako pomorski agent propusti izričito navesti da nastupa u svojstvu agenta, smatra se u odnosu na osobu koja je u dobroj vjeri da radi u svoje ime.

  7. Promoting Multicultural Personality Development: A Strengths-Based, Positive Psychology Worldview for Schools

    Science.gov (United States)

    Ponterotto, Joseph G.; Mendelowitz, David E.; Collabolletta, Ernest A.

    2008-01-01

    This article extends the relevance of multicultural development to the Strengths-Based School Counseling (SBSC; Galassi & Akos, 2007) perspective. A relatively new construct for school counselors, the "multicultural personality" (MP), is introduced and defined. The MP is conceptualized as a cluster of narrow personality traits that…

  8. Author Details

    African Journals Online (AJOL)

    Ako-Nai, RI. Vol 40, No 3 (2010) - Articles “Recycling” of Nigerian Power Elites A Threat to Democratic Consolidation? Abstract. ISSN: 1995-641X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

  9. Original Article

    African Journals Online (AJOL)

    2013-06-22

    Jun 22, 2013 ... (Chia et al., 1993; Ako-Nai et al., 1992), others observed more Gram negative organism like E. coli, Proteus mirabilis, Pseudomonas spp. and. Klebsiella spp. in surgical site infection (Kamat et al., 2008; Efem et al., 1986). *Corresponding author: Emmanuel Nwankwo Email:emmaonwubiko@yahoo.com ...

  10. Clinics in Mother and Child Health - Vol 2, No 2 (2005)

    African Journals Online (AJOL)

    Clinics in Mother and Child Health. ... Purulent pelvic collections in HIV infected female patients: bacterial flora and antibiotic sensitivity. RE Mbu, HMC Fosah, JN Fomulu, RN Tonye, PN Nana, SN Ako, NT Eteki, RG Leke, RJI Leke ... Advanced cancer cases in the Yaounde general hospital, Cameroon. A Ekortarh, P Ndom ...

  11. 75 FR 21253 - Privacy Act of 1974; System of Records

    Science.gov (United States)

    2010-04-23

    ... Issue Facility (CIF): Property book offices and Central Issue Facilities' supply rooms at most Army..., education information, Army Knowledge Online (AKO)user id, living or deceased, military/civilian/foreign... Marketing Office. System manager(s) and address: Delete entry and replace with ``Project Director...

  12. LABORARTORY BRNO

    OpenAIRE

    Krajčová, Petra

    2013-01-01

    Pri hmotovej skladbe som dbala na oslnenie, pohľadové osy, negatívne vplyvy (ako prach a hluk z dopravy) a chodca, ako základnú jednotku života v meste. Začala som uzavretím bloku. Vznikla príliš veľká hmota. Kultúrna inštitúcia ako stavba pre obyvateľov celého mesta by podľa mala byť odlíšená od svojho okolia. Mala by byť výrazna, a iná skladbou konštrukcie, ako aj celým výrazom. V minulosti sa takéto stavby umiestňovali na výrazne miesta, do zelene, kde bol na stavbu dobrý výhľad zo všetkýc...

  13. GPRC6a is not required for the effects of a high-protein diet on body weight in mice.

    Science.gov (United States)

    Kinsey-Jones, James S; Alamshah, Amin; McGavigan, Anne K; Spreckley, Eleanor; Banks, Katherine; Cereceda Monteoliva, Nicholas; Norton, Mariana; Bewick, Gavin A; Murphy, Kevin G

    2015-06-01

    The G-protein coupled receptor family C group 6 member A (GPRC6A) is activated by proteinogenic amino acids and may sense amino acids in the gastrointestinal tract and the brain. The study investigated whether GPRC6A was necessary for the effects of low- and high-protein diets on body weight and food intake in mice. The role of GPRC6A in mediating the effects of a low-protein diet on body weight was investigated in GPRC6a knockout (GPRC6a-KO) and wild-type (WT) mice fed a control diet (18% protein) or a low-protein diet (6% protein) for 9 days. The role of GPRC6A in mediating the effects of a high-protein diet on body weight was investigated in GPRC6a-KO and WT mice fed a control diet (18% protein) or a high-protein diet (50% protein) for 5 weeks. A high-protein diet reduced body weight gain and food intake compared with a control diet in both WT and GPRC6a-KO mice. A low-protein diet decreased body weight gain in GPRC6a-KO mice. GPRC6A was not necessary for the effects of a low- or high-protein diet on body weight and likely does not play a role in protein-induced satiety. © 2015 The Obesity Society.

  14. BOOK REVIEW FOOD AND AGRICULTURAL LAW: READINGS ON ...

    African Journals Online (AJOL)

    BOOK REVIEW. FOOD AND AGRICULTURAL LAW: READINGS. ON SUSTAINABLE AGRICULTURE AND THE. LAW IN NIGERIA. Edited by Rhuks T. Ako and Damilola S. Olawuyi ... of environment, soils, feed quality, trade, land tenure, human rights, climate change ... for any study of agricultural processes and methods:.

  15. 76 FR 14953 - Notice of Availability of Draft Environmental Impact Statement for the Proposed Honolulu Seawater...

    Science.gov (United States)

    2011-03-18

    ... Environmental Impact Statement for the Proposed Honolulu Seawater Air Conditioning Project, Honolulu, HI AGENCY... Honolulu Seawater Air Conditioning, LLC to construct a seawater air conditioning system (SWAC) at Kaka`ako... air conditioning system for downtown Honolulu buildings. In order to obtain deep, cold seawater to...

  16. Author Details

    African Journals Online (AJOL)

    Ako, Essien-Eyo. Vol 8, No 3 (2011) - Articles A Semiotics of Cartoons in Two Nigerian Newspapers: The Punch and The Guardian Abstract. ISSN: 1813-2227. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

  17. Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis.

    Science.gov (United States)

    Alonso, Cristina; Fernández-Ramos, David; Varela-Rey, Marta; Martínez-Arranz, Ibon; Navasa, Nicolás; Van Liempd, Sebastiaan M; Lavín Trueba, José L; Mayo, Rebeca; Ilisso, Concetta P; de Juan, Virginia G; Iruarrizaga-Lejarreta, Marta; delaCruz-Villar, Laura; Mincholé, Itziar; Robinson, Aaron; Crespo, Javier; Martín-Duce, Antonio; Romero-Gómez, Manuel; Sann, Holger; Platon, Julian; Van Eyk, Jennifer; Aspichueta, Patricia; Noureddin, Mazen; Falcón-Pérez, Juan M; Anguita, Juan; Aransay, Ana M; Martínez-Chantar, María Luz; Lu, Shelly C; Mato, José M

    2017-05-01

    Nonalcoholic fatty liver disease (NAFLD) is a consequence of defects in diverse metabolic pathways that involve hepatic accumulation of triglycerides. Features of these aberrations might determine whether NAFLD progresses to nonalcoholic steatohepatitis (NASH). We investigated whether the diverse defects observed in patients with NAFLD are caused by different NAFLD subtypes with specific serum metabolomic profiles, and whether these can distinguish patients with NASH from patients with simple steatosis. We collected liver and serum from methionine adenosyltransferase 1a knockout (MAT1A-KO) mice, which have chronically low levels of hepatic S-adenosylmethionine (SAMe) and spontaneously develop steatohepatitis, as well as C57Bl/6 mice (controls); the metabolomes of all samples were determined. We also analyzed serum metabolomes of 535 patients with biopsy-proven NAFLD (353 with simple steatosis and 182 with NASH) and compared them with serum metabolomes of mice. MAT1A-KO mice were also given SAMe (30 mg/kg/day for 8 weeks); liver samples were collected and analyzed histologically for steatohepatitis. Livers of MAT1A-KO mice were characterized by high levels of triglycerides, diglycerides, fatty acids, ceramides, and oxidized fatty acids, as well as low levels of SAMe and downstream metabolites. There was a correlation between liver and serum metabolomes. We identified a serum metabolomic signature associated with MAT1A-KO mice that also was present in 49% of the patients; based on this signature, we identified 2 NAFLD subtypes. We identified specific panels of markers that could distinguish patients with NASH from patients with simple steatosis for each subtype of NAFLD. Administration of SAMe reduced features of steatohepatitis in MAT1A-KO mice. In an analysis of serum metabolomes of patients with NAFLD and MAT1A-KO mice with steatohepatitis, we identified 2 major subtypes of NAFLD and markers that differentiate steatosis from NASH in each subtype. These might be

  18. Koncept urbanih legendi

    Directory of Open Access Journals (Sweden)

    Ljubomir Hristić

    2016-03-01

    Full Text Available Proučavanje legendi najtransparentnije je polje istraživanja, jer priče kojima ljudi veruju predstavljaju bitnu stavku u njihovom svetonazoru. "Ako je istinito, onda je važno", aksiom je kome treba verovati, bez obzira da li je zaista istinito ili ne. Sama činjenica da smo svesni ovog modernog folklora, koji nam je svima manje-više svojstven, otkrovenje je po sebi; ali ako odemo korak dalje i uporedimo ove priče, izdvojimo njihove stalne teme i povežemo ih sa kulturom, možemo steći plodonosan uvid u globalni/lokalni duh vremena.

  19. Database Description - SSBD | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available ako Tohsato Creator Affiliation: RIKEN Quantitative Biology Center, Laboratory for Developmental Dynamics Cr...eator Name: Kenneth H. L. Ho Creator Affiliation: RIKEN Quantitative Biology Cent...er, Laboratory for Developmental Dynamics Creator Name: Koji Kyoda Creator Affiliation: RIKEN Quantitative Biology... Center, Laboratory for Developmental Dynamics Creator Name: Shuichi Onami* Creator Affiliation: RIKEN Quantitative Biology...ss 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan, RIKEN Quantitative Biology Center Shuichi On

  20. Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice.

    Directory of Open Access Journals (Sweden)

    Junya Fujimoto

    2010-07-01

    Full Text Available Improved understanding of lung cancer development and progression, including insights from studies of animal models, are needed to combat this fatal disease. Previously, we found that mice with a knockout (KO of G-protein coupled receptor 5A (Gprc5a develop lung tumors after a long latent period (12 to 24 months.To determine whether a tobacco carcinogen will enhance tumorigenesis in this model, we administered 4-(methylnitrosamino-1-(3-pyridyl-1-butanone (NNK i.p. to 2-months old Gprc5a-KO mice and sacrificed groups (n=5 of mice at 6, 9, 12, and 18 months later. Compared to control Gprc5a-KO mice, NNK-treated mice developed lung tumors at least 6 months earlier, exhibited 2- to 4-fold increased tumor incidence and multiplicity, and showed a dramatic increase in lesion size. A gene expression signature, NNK-ADC, of differentially expressed genes derived by transcriptome analysis of epithelial cell lines from normal lungs of Gprc5a-KO mice and from NNK-induced adenocarcinoma was highly similar to differential expression patterns observed between normal and tumorigenic human lung cells. The NNK-ADC expression signature also separated both mouse and human adenocarcinomas from adjacent normal lung tissues based on publicly available microarray datasets. A key feature of the signature, up-regulation of Ube2c, Mcm2, and Fen1, was validated in mouse normal lung and adenocarcinoma tissues and cells by immunohistochemistry and western blotting, respectively.Our findings demonstrate that lung tumorigenesis in the Gprc5a-KO mouse model is augmented by NNK and that gene expression changes induced by tobacco carcinogen(s may be conserved between mouse and human lung epithelial cells. Further experimentation to prove the reliability of the Gprc5a knockout mouse model for the study of tobacco-induced lung carcinogenesis is warranted.

  1. Synthesis, structures and variable temperature mag

    Indian Academy of Sciences (India)

    Ako A M, Hewitt I J, Mereacre V, Clérac R, Wernsdorfer. W, Anson C E and Powell A K 2006 Angew. Chem., Int. Ed. 45 4926. 6. Caneschi A, Gatteschi D, Sessoli R, Barra A L, Bruel. L C and Guillot M 1991 J. Am. Chem. Soc. 113 5873. 7. Novitchi G, Wernsdorfer W, Chibotaru L F, Costes J-P,. Anson C E and Powell A K 2009 ...

  2. Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis.

    Science.gov (United States)

    Kuo, Taiyi; Chen, Tzu-Chieh; Lee, Rebecca A; Nguyen, Nguyen Huynh Thao; Broughton, Augusta E; Zhang, Danyun; Wang, Jen-Chywan

    2017-06-01

    Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous lipolysis causes metabolic disorders, including dyslipidemia and hepatic steatosis. Glucocorticoid-induced lipolysis requires the phosphorylation of cytosolic hormone-sensitive lipase (HSL) and perilipin 1 (Plin1) in the lipid droplet by protein kinase A (PKA). We previously identified Pik3r1 (also called p85α ) as a glucocorticoid receptor target gene. Here, we found that glucocorticoids increased HSL phosphorylation, but not Plin1 phosphorylation, in adipose tissue-specific Pik3r1 -null (AKO) mice. Furthermore, in lipid droplets, the phosphorylation of HSL and Plin1 and the levels of catalytic and regulatory subunits of PKA were increased by glucocorticoids in wild-type mice. However, these effects were attenuated in AKO mice. In agreement with reduced WAT lipolysis, glucocorticoid- initiated hepatic steatosis and hypertriglyceridemia were improved in AKO mice. Our data demonstrated a novel role of Pik3r1 that was independent of the regulatory function of phosphoinositide 3-kinase in mediating the metabolic action of glucocorticoids. Thus, the inhibition of Pik3r1 in adipocytes could alleviate lipid disorders caused by excess glucocorticoid exposure. © 2017 by the American Diabetes Association.

  3. Phenolic compounds variation in Mentha L. Species in the course of a four-years period / Kolísanie fenolových látok v rôznych druhoch Mentha L. Počas 4 ročného obdobia

    Directory of Open Access Journals (Sweden)

    Fialová S.

    2015-06-01

    Full Text Available Mäty patria medzi významné rastliny čeľade Lamiaceae. Okrem silice obsahujú množstvo cenných fenolových látok, vrátane flavonoidov a fenolových kyselín, ktoré sa spolupodieľajú na farmakologickej aktivite mäty. V našej práci sme hodnotili kolísanie obsahu fenolových látok počas 4 rokov vegetácie. Pri 1- až 4-ročných rastlinách sme porovnali v suchých listoch obsah hydroxyškoricových derivátov vyjadrených ako kyselina rozmarínová (λ = 505 nm, polyfenolov a trieslovín vyjadrených ako kyselina rozmarínová (λ = 760 nm a flavonoidov vyjadrených ako luteolín-7-O-glukozid (λ = 392 nm a kvercetín (λ = 420 nm. Využili sme spektrofotometrické metódy Európskeho liekopisu. Naše výsledky poukazujú na vysoké hodnoty fenolových látok najmä v 3- a 4-ročných porastoch.

  4. Efficiency Analysis of Solar Facilities for Building Heating and Household Water Heating Under Conditions in the Czech Republic / Analýza Efektivity Solárnych Zariadení Pre Ohrev Úžitkovej Vody A Vykurovanie Budov V Podmienkach Českej Republiky

    Directory of Open Access Journals (Sweden)

    Pivko Michal

    2012-10-01

    Full Text Available Štúdia v tomto článku sa zaoberá efektivitou solárnych zariadení pre ohrev úžitkovej vody a vykurovanie budov v Českej republike. Česká republika je situovaná v miernom podnebnom pásme, to by malo byť brané do úvahy pri inštalácii solárnych zariadení. Efektivita solárnych zariadení je hodnotená podľa energetických a ekonomických bilancií. Analyzované sú solárne zariadenia pre ohrev úžitkovej vody a vykurovanie budov. Hlavný problém súvisí s implementáciou solárnych zariadení a ich prevádzka v miernom podnebnom pásme so striedajúcimi sa horúcimi letami a chladnými zimami.

  5. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue.

    Science.gov (United States)

    Cederquist, Carly T; Lentucci, Claudia; Martinez-Calejman, Camila; Hayashi, Vanessa; Orofino, Joseph; Guertin, David; Fried, Susan K; Lee, Mi-Jeong; Cardamone, M Dafne; Perissi, Valentina

    2017-01-01

    Insulin signaling plays a unique role in the regulation of energy homeostasis and the impairment of insulin action is associated with altered lipid metabolism, obesity, and Type 2 Diabetes. The main aim of this study was to provide further insight into the regulatory mechanisms governing the insulin signaling pathway by investigating the role of non-proteolytic ubiquitination in insulin-mediated activation of AKT. The molecular mechanism of AKT regulation through ubiquitination is first dissected in vitro in 3T3-L1 preadipocytes and then validated in vivo using mice with adipo-specific deletion of GPS2, an endogenous inhibitor of Ubc13 activity (GPS2-AKO mice). Our results indicate that K63 ubiquitination is a critical component of AKT activation in the insulin signaling pathway and that counter-regulation of this step is provided by GPS2 preventing AKT ubiquitination through inhibition of Ubc13 enzymatic activity. Removal of this negative checkpoint, through GPS2 downregulation or genetic deletion, results in sustained activation of insulin signaling both in vitro and in vivo . As a result, the balance between lipid accumulation and utilization is shifted toward storage in the adipose tissue and GPS2-AKO mice become obese under normal laboratory chow diet. However, the adipose tissue of GPS2-AKO mice is not inflamed, the levels of circulating adiponectin are elevated, and systemic insulin sensitivity is overall improved. Our findings characterize a novel layer of regulation of the insulin signaling pathway based on non-proteolytic ubiquitination of AKT and define GPS2 as a previously unrecognized component of the insulin signaling cascade. In accordance with this role, we have shown that GPS2 presence in adipocytes modulates systemic metabolism by restricting the activation of insulin signaling during the fasted state, whereas in absence of GPS2, the adipose tissue is more efficient at lipid storage, and obesity becomes uncoupled from inflammation and insulin

  6. Ujednačavanje pomorskog prava i interesi Hrvatske

    OpenAIRE

    Grabovac, Ivo

    2004-01-01

    Republika Hrvatska, kao pomorska država, ima osobit interes pratiti unifikacijske težnje u uređenju pomorskopravnih odnosa. Hrvatska je poglavito dužna ratificirati i primjenjivati konvencije i dogovore iz područja sigurnosti plovidbe, njihove česte izmjene i dopune (osobito SOLAS), jer je riječ o danas općeprihvaćenim međunarodnim obvezama koje brodovi moraju ispunjavati ako žele nesmetano uplovljavati u inozemne luke. Isto je tako neosporno da su interesi RH u pomorskom poduzetništvu prihva...

  7. Sintaksa i semantika u suprotan koordinacije i zamjene

    Directory of Open Access Journals (Sweden)

    Pavao Tekavčić

    1978-12-01

    Full Text Available U onome što se obično naziva adverzativnim rečenicama valja razlikovati dva tipa: adverzativne rečenice (u užem smislu, kojima se izriče kontrast (Laura è bella ma è antipatica, i supstitutivne rečenice, kojima se prvi član ukida i zamjenjuje drugim (Laura non è bella bensì ( è brutta. U studiju ovih dvaju tipova rečenica mogu se razlikovati neke sintaktičke i semantičke kategorije: 1 identitet/kontrast, 2 djelomičnost/potpunost, S afirmacija/ negacija svakoga od dvaju članova, 4 pozitivno/negativno (semantičko značenje članova. U članku se studira semantička prihvatljivost rečenica, restrikcije u upotrebi triju glavnih veznika (però, bensì, ma i mogućnost elipse drugoga pomoćnog glagola. Ako prvi član (A nije negiran, moguć je jedino veznik u značenju 'ali', ali samo onda ako se radi o djelomičnom identitetu i djelomičnom kontrastu, dok je isključen ako se izražava potpuni identitet (*Laura è bella pero è bella ili potpuni kontrast (*Laura è bella pero è brutta. Veznik pero u današnjem talijanskom jeziku ima samo značenje 'ali' Ako je prvi član negiran, uz 'ali' moguce je i 'nego' (tal.bensì, ali s razlikom u značenju (Laura non è bella pero è simpatica. I Laura non è bella bensi è simpatica. Veznik 'nego' isključen je samo onda kada se izražava potpuni identitet (jer nema smisla zamjenjivati jedan pojam drugim, ako su identični, dok je u drugim slučajevima - uz veće ili manje razlike, i ev u posebnim slučajevima - prihvatljiv. Dok però znači samo 'ali' a bensì samo 'nego', treći veznik, ma, koji je danas najčešći, pokriva oba ta značenja. Stoga, ako je prvi član negiran, može doći do dvoznačnosti: Laura non è bella, ma è simpatica može značiti da L. nije lijepa nego simpatična (supstitutivna reč. ili da nije lijepa ali  je simpatična (adverzativna reč.. U takvim rečenicama elipsa drugoga pomoćnog glagola postaje distinktivna: dok će se rečenica Laura non è bella

  8. The Foreign Policy of Venezuela Toward El Salvador: 1979-1983

    Science.gov (United States)

    1990-06-01

    stamos a largo plazo. La duraci6n del Programa f ue de un aKo, renovable anualmente, previo acuerdo mutuo. En el primer afto de vigencia del acuerdo, los...affo de vigencia del Acuerdo, El Salvador recibi6 una parte considerable de los beneficios financieros del Acuerdo de San Jasd. Nicaragua, en contraste...aspectos que desfavorecian a Nicaragua -tal como la reducci6n de armas ya existentes en la reg16n - serian asunto de negociaciones futuras (42). Se quej6

  9. Probiotički koncept – probiotici kao dodaci hrani i probiotici kao bioterapeutici

    OpenAIRE

    Šušković, Jagoda; Kos, Blaženka; Frece, Jadranka; Beganović, Jasna; Pavunc, Andreja Leboš

    2009-01-01

    Svjetska zdravstvena kriza, posebice u liječenju infektivnih bolesti zbog alarmantnog stanja s antibiotičkom rezistencijom te niz kroničnih bolesti koje ugrožavaju ljudsko zdravlje, proizvelo je situaciju za uspostavljanje koncepta funkcionalne hrane još 1980. godine, u Japanu. Dakle, hrana je funkcionalna ako sadrži sastojke koji pozitivno djeluju na jednu ili više ciljanih funkcija u tijelu. Ciljno mjesto djelovanja probiotika, prebiotika, odnosno sinbiotika, kao funkcionalnih dodataka hran...

  10. Prognostički čimbenici uspjeha različitih barijatrijskih zahvata

    OpenAIRE

    Mirošević, Gorana

    2015-01-01

    Debljina je kronična endokrino-metabolička bolest karakterizirana prekomjernim nakupljanjem masti u organizmu i povećanjem tjelesne težine. To je bolest koja se treba liječiti jer ako se ne liječi napreduje i sa sobom nosi rizik nastanka različitih kliničkih komplikacija. U slučajevima ekstremne debljine u obzir dolazi liječenje intragastričnim balonom ili barijatrijskim kirurškim zahvatom. Liječenje intragastričnim balonom (BIB) provodi se u periodu od šest mjeseci. Barijatrijsko kirurško li...

  11. Utjecaj stupnja uglazbljenosti teksta na upamćivanje teksta

    OpenAIRE

    Mutak, Augustin; Vranić, Andrea

    2017-01-01

    Introspektivni nalazi pokazuju kako ljudi lakše i dulje pamte uglazbljeni materijal od drugih vrsta materijala. Sukladno tome, pokazuje se i da ljudi vjeruju da je glazba dobar mnemonik te da pomaže upamćivanju. Međutim, eksperimentalne provjere ne potvrđuju ove teze. U eksperimentima se pokazuje kako je pozitivan utjecaj glazbe na upamćivanje ovisan o uvjetima upamćivanja (npr. uglazbljen i neuglazbljen tekst pamte se jednako dobro ako je brzina prezentiranja riječi ista). Utjecaj stupnja ug...

  12. Konceptualni pristup u uličnoj fotografiji

    OpenAIRE

    Toplek, Ana

    2017-01-01

    Tijekom godina pojavile su se mnoge teorije vezane uz uličnu fotografiju, s obzirom na niz aspekata, uključujući stil, pravila i ciljeve, kao i opću valjanost stila, jer ovu vrstu fotografije ne treba poduzeti na stvarnoj ulici, ona može biti snimljena i ako se uzme u zatvorenom prostoru, dok je to sve javno okruženje u kojem se snima. Ulična fotografija ima samo jedno strogo pravilo i to bi trebalo biti da pravi zrcalo društva, nepromijenjenu scenu sa nesvjesnim predmetim...

  13. Šuplje ziđe od opeke i međusobni spoj sa sljubnicama morta

    OpenAIRE

    Penava, Davorin; Sigmund, Vladimir; Kožar, Ivica; Anić, Filip; Trajber, Domagoj; Vig, Mirko

    2016-01-01

    Ako se pri izvedbi konstrukcijskog ziđa upotrebljevaju opečni zidni elementi s vertikalnim šupljinama i mort opće namjene, tijekom ispunjavanja sljubnica nastupa prodiranje morta u šupljine zidnog elementa. Otpornost pri posmiku određuje se na jednak način za ziđe od punih ili šupljih opečnih zidnih elemenata te stoga utjecaj međusobnog spoja zidnih elemenata i sljubnica morta nije uzet u obzir. Pomoću prostornih nelinearnih proračunskih modela i usporedbom s odzivom fizikalnih modela provjer...

  14. SOCIJALNA OBILJEŽJA SVAKODNEVNOG ŽIVOTA DJECE I MLADIH S ADHD-om, TE NJIHOVIH RODITELJA

    OpenAIRE

    Bartolac, Andrea

    2013-01-01

    Prepoznavanje i razumijevanje različitih uzroka i pojavnosti ponašanja djece, osobito ako se razvoj i primjena socijalnih kompetencija ne odvijaju u okvirima socijalnih očekivanja i normativa, važno je za sve stručnjake koji rade s djecom, bez obzira veže li se njihovo područje djelovanja uz sustav socijalne skrbi, zdravstva ili odgoja i obrazovanja. U ovom se radu na temelju recentnije literature i istraživanja opisuju socijalni aspekti svakodnevnog života jedne od razvojnih teškoća samokont...

  15. Geodetski časopisi u Emerging Sources Citation Indexu

    Directory of Open Access Journals (Sweden)

    Nedjeljko Frančula

    2016-06-01

    U ESCI su uvršteni časopisi od regionalne važnosti i časopisi iz znanstvenih područja u nastajanju. Časopisi uvršteni u ESCI bit će nakon određenog vremena, ako zadovolje kriterije Thomson Reutersa, uvršten u SCIE, SSCI ili A&HCI. Za časopise uvrštene u ESCI, trenutno ih je 2589, ne izračunava se faktor odjeka.

  16. The Body as an Interface

    OpenAIRE

    Kučerák, Michal

    2010-01-01

    MK: Telo ako rozhranie bakalárska esej Abstract: This bachelor thesis discusses the topic of body in video games in philosophical perspective. The main issues are: What is happening with the body of player during the play? How does this "works"? The essay itself contains definition of game as well, definition of video game provided by Juul and roots of video game itself as cyber culture (Levy) and technical image (Flusser). It shows the history and present of video gaming. The question whethe...

  17. KAD DISCIPLINA NIJE DISCIPLINA? ISTRAŽIVANJA INTERDISCIPLINARNIH DRUŠTVENIH ZNANOSTI KAO TEMELJA ZA RAZUMIJEVANJE TURIZMA

    OpenAIRE

    Dann, Graham M. S.

    2016-01-01

    Ovaj rad ponovno istražuje pitanje je li izučavanje turizma znanost, disciplina ili područje. Problem se analizira u sedam faza. Rad prvo istražuje pojam znanosti turizma jer, ako se može dokazati da je turizam metadisciplina, onda ga više ne treba promatrati kao disciplinu. Međutim, s obzirom da je dokazano da to nije tako, treba se usredotočiti na turizam kao disciplinu. Stoga se u sljedećem dijelu daje kratak pregled etimologije discipline. U trećem dijelu opisano je kako je pokrenuta ras...

  18. Mikrobiální produkce karotenoidních pigmentů s využitím odpadních substrátů

    OpenAIRE

    Hároniková, Andrea

    2010-01-01

    Karotenoidy sú prirodzene vyskytujúce sa pigmenty produkované baktériami, kvasinkami, vláknitými hubami i rastlinami. Majú významné biologické účinky s využitím v potravinárskom priemysle, farmácii i kozmetike. Cieľom diplomovej práce poňatej ako zrovnávacia štúdia bola regulácia produkcie karotenoidov a ergosterolu kvasinkami s využitím odpadových substrátov ako srvátka, kukuričné klíčky, pšeničná kaša, jablčná vláknina, cestoviny. Do vybraných produkčných médií boli pridané aj extracelulárn...

  19. Pharmacological Analysis of Vorinostat Analogues as Potential Anti-tumor Agents Targeting Human Histone Deacetylases: an Epigenetic Treatment Stratagem for Cancers.

    Science.gov (United States)

    Praseetha, Sugathan; Bandaru, Srinivas; Nayarisseri, Anuraj; Sureshkumar, Sivanpillai

    2016-01-01

    Alteration of the acetylation status of chromatin and other non-histone proteins by HDAC inhibitors has evolved as an excellent epigenetic strategy in treatment of cancers. The present study was sought to identify compounds with positive pharmacological profiles targeting HDAC1. Analogues of Vorinostat synthesized by Cai et al, 2015 formed the test compounds for the present pharmacological evaluation. Hydroxamte analogue 6H showed superior pharmacological profile in comparison to all the compounds in the analogue dataset owing to its better electrostatic interactions and hydrogen bonding patterns. In order to identify compounds with even better high affinity and pharmacological profile than 6H and Vorinostat, virtual screening was performed. A total of 83 compounds similar to Vorinostat and 154 compounds akin to analogue 6H were retrieved. SCHEMBL15675695 (PubCid: 15739209) and AKOS019005527 (PubCid: 80442147) similar to Vorinostat and 6H, were the best docked compounds among the virtually screened compounds. However, in spite of having good affinity, none of the virtually screened compounds had better affinity than that of 6H. In addition SCHEMBL15675695 was predicted to be a carcinogen while AKOS019005527 is Ames toxic. From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report Vorinostat hydroxamate analogue 6H to be a potential candidate for HDAC inhibition in treatment of cancers through an epigenetic strategy.

  20. Determination of gamma radiation shielding characteristics of some tropical woods

    International Nuclear Information System (INIS)

    Aigbosuria, E. F.

    2011-01-01

    This study compares the shielding characteristics of twenty-two tropical woods by using gamma scintillation detection method. Woods sourced are Anogeisus Leiocarpus(Ayin), Nesogordonia Papverifera(Oro), Entandrophragma Microphyllum(Anunje), Brachystagia Eurycoma(Ako), Cassia Alata(Asunrun), Afzelia Africana(Apa-Igbo), Khaya Grandifoliala(Gedu), Piptadenistrum Africana(Agbonyin), Nanclea Diderrehii(Opepe), Khaya Ivorensis(Oganwo), Chlorophora Excelsa(Iroko), Masonia altissima(Odogi), Entandrophragma Angolense(Ijebo), Altium Sativum(Ayo), Albizia Zygia(Ayunre), Terminalia Superba(Afara), Cordia Millenii(Omo), Melania(Melania), Pycnanthus Angolensis(Akomu), Triplochitons Scleroxylon(Arere), Pine(Pine), Ceiba Pentradra(Araba). The intensities of the emergent radiation were measured, when each of these woods were placed between a scintillation detector and a standard radioactive source. Analysis of result obtained shows an appreciable evidence of radiation attenuation due to the changes in the chemical composition of the woods and the dependence of the attenuation coefficient on energy and densities of these woods. The descending order of attenuation coefficient determined are; Ayin, Oro, Anuje, Ako, Asunrun, Apa-igbo Gedu, Agbonyin, Opepe Oganwo, Iroko Odogi , Ayo, Ayunre, Afara, Omo, Melania, Akomu, Arere, Pine, Araba. For a constant energy of 0.101MeV, the attenuation coefficient are 0.190cm -1 , 0.165cm -1 , 0.163cm -1 , 0.156cm -1 , 0.149cm -1 , 0.143cm -1 , 0.133cm -1 , 0.132cm -1 , 0.127cm -1 , 0.124cm -1 , 0.085cm -1 , 0.123cm -1 , 0.122cm -1 , 0.113cm -1 , 0.101cm -1 , 0.088cm -1 , 0.087cm -1 , 0.086cm -1 , 0.082cm -1 respectively. The wood in descending order of dependence of attenuation coefficient on density are: Ayin,Oro, Anunje,Ako,Asunrun,Apa-Igbo, Gedu, Agbonyin, Opepe, Oganwo, Iroko, Odogi, Ijebo, Ayo, Ayunre, Afara, Omo, Melania, Akomu, Arere, Pine and Araba. The half value layer shows the thickness at various energy regions.

  1. Záujem žiakov nižšieho sekundárneho vzdelávania o biologické vedy

    Directory of Open Access Journals (Sweden)

    Jana Fančovičová

    2015-07-01

    Full Text Available Záujem žiakov o prírodovedné predmety celosvetovo klesá a žiaci ako dôvody nezáujmu uvádzajú náročnosť a nedôležitosť daných predmetov pre ich život a budúce povolanie. Cieľom výskumného šetrenia bolo zistiť, aká oblasť z prírodovedných predmetov žiakov zaujíma najviac, a tiež vplyv premenných ako sú gender a vek na záujem o biologické vedy (predpokladali sme, že žiaci prejavia najväčší záujem o biologické vedy. Výskumu sa zúčastnilo 389 žiakov nižšieho sekundárneho vzdelávania vo veku 10–15 rokov. Každý respondent mal na čistý hárok papiera uviesť ľubovoľný počet spontánnych otázok – mal napísať otázky, ktorých odpoveď ho zaujíma. Viac ako 91 % všetkých otázok predstavovali otázky z biológie a nie z fyziky alebo chémie. Väčší záujem o biológiu bol zistený u dievčat. Z oblasti biológie bolo najviac otázok položených v šiestom ročníku a najmenej v piatom ročníku, čo je pravdepodobne spôsobené obsahom kurikula. Tento jav je vysvetlený v záverečnej kapitole článku.

  2. Modely výškových kriviek jedľovo-bukových porastov Východných Karpát / Models of height curves in fir-beech stands of the Eastern Carpathians

    Directory of Open Access Journals (Sweden)

    Klouček Tomáš

    2015-06-01

    Full Text Available Odvodili sa modely výškových kriviek z experimentálneho materiálu opakovaných meraní šiestich trvalých výskumných plôch na výskumnom objekte Komárnik vo Východných Karpatoch. Počas viac ako 50-ročného sledovania sa zmeralo 1 346 výšok pre buk a 1 208 pre jedľu. Výšky majú všeobecne veľkú variabilitu, ale nepreukázal sa štádiový posun výškových kriviek. Odvodili sa nelineárne regresné modely výškových kriviek pre buk a jedľu, kde výška stromu je funkciou jeho hrúbky a modelovej výšky pre zvolený hrúbkový stupeň. Ich základom je Korfova rastová krivka s tromi parametrami. Modelom je vysvetlených 90 % variability výšok pri buku a 94 % pri jedli. Modely potvrdili doterajšie poznatky, že jedľa má najmä pri hrubších stromoch vyššie výškové prírastky ako buk. V porovnaní k modelom iných autorov majú odvodené modely málo odlišný tvar výškových kriviek. Buk má väčšiu a jedľa menšiu krivosť ako porovnávané modely. Modely majú vzhľadom na obmedzený rozsah experimentálneho materiálu len lokálny charakter. Pre miestne pomery sa môžu aplikovať na bonitovanie a simulovanie vývoja zásob a prírastku nerovnovekých a viacetážových jedľovo-bukových porastov.

  3. Polyphenolic compounds and essential oil analysis of selected species of the genus Thymus / Analýza fenolových zložiek a analýza silice vybraných druhov rodu Thymus

    Directory of Open Access Journals (Sweden)

    Kameníková M.

    2015-06-01

    Full Text Available Predložena praca bola zamerana na stanovenie obsahu vybranych fenolovych zlučenin (celkove fenoly, triesloviny, flavonoidy a antokyany troch roznych druhov rodu Thymus (T. pulegioides, T. pannonicus, T. praecox s rozdielnym povodom (Českomoravska vrchovina, Křivoklat a Považsky Inovec. Na stanovenie tychto zložiek boli využite spektrofotometricke metody Europskeho liekopisu, 8. vydanie. Zaroveň bol stanoveny aj obsah silice a bola vykonana analyza jej zložiek. Obsah celkovych polyfenolov bol stanoveny spektrofotometrickou metodou s využitim Folin-Ciocalteovho činidla. Obsah kolisal od 3.87 % do 8,86 %. Obsah trieslovin bol realizovany na zaklade predošleho stanovenia obsahu celkovych fenolov, a to adsorpciou trieslovin na kožny prašok. Ich obsah sa pohyboval v rozmedzi 1,96 % do 5,65 %. Na stanovenie obsahu flavonoidov bola využita spektrofotometricka metoda s chloridom hlinitym. Obsah flavonoidov vyjadrenych ako luteolin-7-O-glukozid (λ = 392 nm kolisal od 0,59 % do 1,52 % a obsah flavonoidov vyjadrenych ako rutin (λ = 420 nm sa pohyboval v rozmedzi od 0,41 % do 1,12 %. Antokyany zaberaju v ramci fenolovych zložiek rodu Thymus len minimalny podiel. V našich vzorkach bol obsah antokyanov vyjadreny ako cyanidin-3- O-glukozid a kolisal od 0,02 % do 0,1 %. Na stanovenie obsahu silice bola využita metoda Europskeho liekopisu, 8.vydanie. Obsah silice sa pohyboval v rozmedzi od 0,2 % do 0,75 %. Na analyzu silice bola nasledne využita metoda plynovej chromatografie s hmotnostnou spektrometriou. Na zaklade tejto analyzy bola zistena pritomnosť troch chemotypov silice, a to tymoloveho, karvakroloveho a linalooloveho chemotypu. Vďaka variaciami chemickeho zloženia silice, bolo možne pozorovať vzťah medzi pritomnosťou určiteho chemotypu a povodom vzorky. Rozdiely v stanoveni obsahu flavonoidov nepreukazali žiadny vyrazny vzťah k lokalite povodu.

  4. Restauracije mliječnih zuba cirkonijskim krunicama kod djece s ranim karijesom

    OpenAIRE

    Karaca, Serhat; Ozbay, Gizem; Kargul, Betul

    2013-01-01

    Rani dječji karijes (ECC) razarajući je oblik truljenja zuba koji pogađa predškolsku djecu. Obično se pojavljuje na mliječnim maksilarnim sjekutićima dojenčadi i vrlo male djece. Ti su zubi vrlo važni za fizički izgled, pa ako nestane njihova struktura to ne utječe samo na estetiku nego kompromitira i žvakanje, a uzrokuje i teškoće u socijalnoj i psihološkoj prilagodbi djeteta. Estetska restauracija mliječnih sjekutića može se obaviti različitim materijalima, primjerice, gotovim cirkonijs...

  5. Kristološki naglasci govora o Božjem milosrđu u promišljanjima izabranih crkvenih otaca

    OpenAIRE

    Filić, Andrea

    2017-01-01

    Polazišno pitanje ovoga članka, nadahnuto tvrdnjama Waltera Kaspera, glasi: Ako milosrđe po definiciji u sebi nužno uključuje trpljenje može li se, dok držimo sigurnim da je netrpljivost jedna od bitnih vlastitosti božanske naravi, o njemu uopće govoriti, kako Kasper potiče, kao o temeljnom Božjem svojstvu i odrednici Božje biti? To se pitanje i odgovor na nj obrađuje pod kristološkim vidom i to na temelju promišljanja izabranih crkvenih otaca u čijim djelima pronalazimo govor o Božjem milosr...

  6. Investigation of Lithium Thionyl Chloride Battery Safety Hazards.

    Science.gov (United States)

    1982-06-30

    8217;A- ’ 41%0 7r 4 2~ -A- CW.A, - A A *’ A . R, IT) 0 -- I tfl V) co (0 akO 2 I’l 0 igbo irabo tifo 12ඎ 1 0 80o 6k 0 § WAVENUMBERS I 1 N~WC S~ETYs2 5...L’O 2󈨊 1060 8150 dt 0 i󈧢 WAVENUMBERS I 103O% OVEIOISL- (D EL ~crR3YTrE =90M 100% O0SLIARED C.EL!. srAfNDIN6 b W’EV-S IL18 0 Ij.: z Iin 7 To ND 0

  7. FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis

    DEFF Research Database (Denmark)

    Mottillo, Emilio P; Desjardins, Eric M; Fritzen, Andreas Mæchel

    2017-01-01

    1β2AKO) and littermate controls were fed a high fat diet (HFD) and treated with native FGF21 or saline for two weeks. Additionally, HFD-fed mice with knock-in mutations on the AMPK phosphorylation sites of acetyl-CoA carboxylase (ACC)1 and ACC2 (DKI mice) along with wild-type (WT) controls received...... AMPK and were not associated with changes in browning of white (WAT) and brown adipose tissue (BAT). Lastly, we assessed whether FGF21 exerted its effects through the AMPK/ACC axis, which is critical in the therapeutic benefits of the anti-diabetic medication metformin. ACC DKI mice had improved...... the inhibitory action of AMPK on ACC. This is in contrast to the anti-diabetic medication metformin and suggests that the treatment of obesity and diabetes with the combination of FGF21 and AMPK activators merits consideration....

  8. Microwave embrittlement and desulphurisation of coal

    Directory of Open Access Journals (Sweden)

    A.J.Merchant

    1998-09-01

    Full Text Available Mikrovlnné žiarenie frekvencie 2,45 GHz bolo použité na vzorkách uhlia z rôznych anglických lokalit, na ich tepelnú predúpravu pred rozpojovaním. Získané údaje poukazujú na vplyv mikrovlnnej tepelnej úpravy na relatívnu melite¾nos uhlia. Výrazná redukcia ( 20 –40 % relatívnej energie mletia bola zaznamenaná už po pomerne krátkom èase pôsobenia mikrovlnného žiarenia (3 –8 min. Vplyv mikrovlnnej predúpravy na fyzikálnu a chemickú štruktúru uhlia, ako aj na odsírenie uhlia, bol tiež analyzovaný.

  9. Mathematical modelling breakpoints

    OpenAIRE

    Sedlák Vladimír

    1996-01-01

    V príspevku je prezentovaná teória matematického modelovania polynomiálnych lomových bodov pri analýze deformaèných charakteristík poklesových kotlín. Teória urèovania lomových bodov bola vyvinutá ako súèas kinematických analýz horninového masívu dobývacieho loiskového po¾a magnezitu vo východoslovenskom regióne. Teoretické poznatky modelovania sú doplnené praktickými výsledkami deformaèných meraní in situ.

  10. Optimalizácia monitorovania sieťovej prevádzky

    Directory of Open Access Journals (Sweden)

    František Jakab

    2013-06-01

    Full Text Available Tento príspevok sa zaoberá otvorenými problémami vyskytujúcimi sa pri pasívnom prístupe merania sieťových charakteristík. Opisuje najpoužívanejšie prístupy merania sieťových parametrov ako aj charakteristiky, ktoré sa pri monitorovaní najčastejšie sledujú. Hlavným cieľom tohto príspevku je predstavenie konceptuálneho návrhu riešenia opísaných problémov, ktorý by sa mal docieliť automatizovaným prispôsobením exportu záznamov o tokoch prevádzky k aktuálnemu stavu siete.

  11. Návrh kmitočtových filtrů s netradičními aktivními prvky

    OpenAIRE

    Jarník, Lukáš

    2013-01-01

    Táto bakalárska práca je zameraná na návrh kmitočtových filtrov s netradičnými aktívnymi prvkami. Sú tu prezentované aktívne prvky ako sú prúdové konvejory (GCC), napäťové konvejory (GVC), transkonduktančné zosilovače (OTA, CFTA), ktoré pracujú v prúdovom režime. V práci je ďalej navrhnutých a odsimulovaných šesť zapojení s aktívnymi prvkami (GCC), (CFTA), (OTA) a (GVC), ktoré vychádzaju z návrhu podla úplnej admitančnej siete. Jedno zapojenie bolo prakticky zrealizované a experimentálne over...

  12. Magneticky levitující vozítko

    OpenAIRE

    Jančuš, Rastislav

    2014-01-01

    Táto diplomová práca zhrňuje obecné teoretické poznatky v oblasti permanentných magnetov a elektromagnetizmu. Popisuje jednosmerný elektromagnet ako základný stavebný kameň levitujúceho rýchlovlaku. Ďalej sa práca venuje aj základným podvozkom a princípom využívajúcich sa pri levitácii vo vysokorýchlostnej doprave. Druhá praktická časť práce obsahuje návrh konštrukcie levitujúceho vozíku a analýzu získaného matematického modelu elektromagnetu. Práca popisuje postup návrhu riadenia pre bočnú s...

  13. Teritorijalna zamka: Danilo Kiš, kulturna geografija i geopolitička imaginacija

    OpenAIRE

    Milutinović, Z.

    2014-01-01

    Većina pokušaja da se "male", "minorne" ili književnosti "trećeg svijeta" uvrste u veću cjelinu uglavnom su neadekvatni, deduktivni i reducirajući. Male književnosti i njihovi pisci možda žude za priznanjem i pažnjom, ali nije od prevelike pomoći ako im se pristupi sa kompleksom novih stereotipa i sumnjivih generalizacija, koje ih poistovjećuju sa geopolitičkom situacijom nacija kojima pripadaju. Ovaj članak će se fokusirati na Casanovinu knjigu The World Republic of Letters (Svjetska književ...

  14. Internetová reklama pro MSP

    OpenAIRE

    Molnár, Peter

    2007-01-01

    Cielom práce je poukázať na hlavné formy internetovej reklamy, ktoré sa používajú pri reklamných kampaniach. Dalšími cielmi je poukázať na využitie internetovej reklamy z pohladu MSP ako aj návrh reklamnej kampane za použitia internetových foriem reklamy. The aim of this work is to point main forms of internet advertising, used by advertising campaign. The other aims are to point on usage of internet advertising in SME and layout of advertising campaign using internet forms of advertising....

  15. Repressive Epigenetic Changes at the mGlu2 Promoter in Frontal Cortex of 5-HT2A Knockout Mice

    Science.gov (United States)

    Kurita, Mitsumasa; Moreno, José L.; Holloway, Terrell; Kozlenkov, Alexey; Mocci, Giuseppe; García-Bea, Aintzane; Hanks, James B.; Neve, Rachael; Nestler, Eric J.; Russo, Scott J.

    2013-01-01

    Serotonin 5-HT2A and metabotropic glutamate 2 (mGlu2) are G protein–coupled receptors suspected in the pathophysiology of psychiatric disorders, such as schizophrenia, depression, and suicide. Previous findings demonstrate that mGlu2 mRNA expression is down-regulated in brain cortical regions of 5-HT2A knockout (KO) mice. However, the molecular mechanism responsible for this alteration remains unknown. We show here repressive epigenetic changes at the promoter region of the mGlu2 gene in frontal cortex of 5-HT2A-KO mice. Disruption of 5-HT2A receptor-dependent signaling in mice was associated with decreased acetylation of histone H3 (H3ac) and H4 (H4ac) and increased tri-methylation of histone H3 at lysine 27 (H3K27me3) at the mGlu2 promoter, epigenetic changes that correlate with transcriptional repression. Neither methylation of histone H3 at lysine 4 (H3K4me1/2/3) nor tri-methylation of histone H3 at lysine 9 (H3K9me3) was affected. We found that Egr1, a transcription factor in which promoter activity was positively regulated by the 5-HT2A receptor agonist 4-bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide, binds less to the mGlu2 promoter in frontal cortex of 5-HT2A-KO, compared with wild-type mice. Furthermore, expression of mGlu2 was increased by viral-mediated gene transfer of FLAG-tagged Egr1 in mouse frontal cortex. Together, these observations suggest that 5-HT2A receptor–dependent signaling epigenetically affects mGlu2 transcription in mouse frontal cortex. PMID:23508685

  16. Estimation of Avalanche Hazard in the Settlement of Magurka using Elba+ Model / Posúdenie Ohrozenosti Osady Magurky Lavínami S Použitím Modelu Elba+

    Directory of Open Access Journals (Sweden)

    Bartík Martin

    2013-06-01

    Full Text Available V našej študií sme sa zamerali na moderné softvérové aplikácie umožňujúce simuláciu lavíny. Použili sme model ELBA+, pomocou ktorého sme snažili zhodnotiť ohrozenosť horského prostredia v okolí starej banskej osady Magurka (1 036 m n. m., ktorá leží v závere Ľupčianskej doline pod hlavným hrebeňom Nízkych Tatier. Do histórie sa zapísala hlavne lavína v doline Ďurková zo 14. marca 1970, ktorá dodnes patrí medzi najväčšie lavíny zaznamenané na Slovensku. S použitím archívnych údajov Strediska lavínovej prevencie v Jasnej sme sa pokúsili o jej čo najvernejšiu rekonštrukciu. Následne sme sa pokúsili o simuláciu lavíny v doline Viedenka pri použití rovnakej výšky snehu v odtrhovom pásme ako sa predpokladá pri lavíne v roku 1970. Keďže časť osady Magurka je situovaných pri ústí tejto doliny, ktorá má priamejší aj kratší priebeh ako dolina Ďurková, skúmali sme možnosť jej zásahu lavínou.

  17. Bone Regeneration in Critical Bone Defects Using Three-Dimensionally Printed β-Tricalcium Phosphate/Hydroxyapatite Scaffolds Is Enhanced by Coating Scaffolds with Either Dipyridamole or BMP-2

    Science.gov (United States)

    Ishack, Stephanie; Mediero, Aranzazu; Wilder, Tuere; Ricci, John L.; Cronstein, Bruce N.

    2017-01-01

    Bone defects resulting from trauma or infection need timely and effective treatments to restore damaged bone. Using specialized three-dimensional (3-D) printing technology we have created custom 3-D scaffolds of hydroxyapatite (HA)/Beta-Tri-Calcium Phosphate (β-TCP) to promote bone repair. To further enhance bone regeneration we have coated the scaffolds with dipyridamole, an agent that increases local adenosine levels by blocking cellular uptake of adenosine. 15% HA:85% β-TCP scaffolds were designed using Robocad software, fabricated using a 3-D Robocasting system, and sintered at 1100°C for 4h. Scaffolds were coated with BMP-2 (200ng/ml), Dypiridamole 100µM or saline and implanted in C57B6 and adenosine A2A receptor knockout (A2AKO) mice with 3mm cranial critical bone defects for 2-8 weeks. Dipyridamole release from scaffold was assayed spectrophotometrically. MicroCT and histological analysis were performed. micro-computed tomography (microCT) showed significant bone formation and remodeling in HA/β-TCP- dipyridamole and HA/β-TCP -BMP-2 scaffolds when compared to scaffolds immersed in vehicle at 2, 4 and 8 weeks (n=5 per group; p≤ 0.05, p≤ 0.05 and p≤ 0.01, respectively). Histological analysis showed increased bone formation and a trend toward increased remodeling in HA/β-TCP- dipyridamole and HA/β-TCP-BMP-2 scaffolds. coating scaffolds with dipyridamole did not enhance bone regeneration in A2AKO mice. In conclusion, scaffolds printed with HA/β-TCP promote bone regeneration in critical bone defects and coating these scaffolds with agents that stimulate A2A receptors and growth factors can further enhance bone regeneration. These coated scaffolds may be very useful for treating critical bone defects due to trauma, infection or other causes. PMID:26513656

  18. Similar foliage area but contrasting foliage biomass between young beech and spruce stands / Porovnateľná plocha avšak kontrastná biomasa asimilačných orgánov medzi mladými porastmi buka a smreka

    Directory of Open Access Journals (Sweden)

    Konôpka Bohdan

    2014-12-01

    Full Text Available Výskum sa zameral na mladé porasty buka lesného (Fagus sylvatica a smreka obyčajného (Picea abies rovnakého veku (12 rokov, veľmi podobných dimenzií stromov, rastúcich na totožnom stanovišti. Na základe odberu vzorníkov celých stromov (všetky časti okrem jemných koreňov sme skonštruovali alometrické vzťahy pre stromové komponenty. Ako nezávislá premenná sa použila hrúbka na báze kmeňa (d0. Modely vyjadrili nielen biomasu konárov, kmeňa, hrubých koreňov a asimilačných orgánov, ale aj plochu asimilačných orgánov a špecifickú listovú plochu (specific leaf area; SLA. Zistili sme, že základné morfologické vlastnosti asimilačných orgánov varírovali pri obidvoch drevinách pozdĺž vertikálneho profilu koruny. V prípade smreka sa zistili odlišné hodnoty plochy ihlíc a SLA medzi jednotlivými ročníkmi ihlíc. Na úrovni stromu mali buky oveľa viac biomasy drevných častí ako smreky, opačná situácia bola pri asimilačných orgánoch. Preto hodnoty podielu medzi biomasou asimilačných orgánov a celkovou biomasou stromu, ako aj pomeru medzi plochou asimilačných orgánov a celkovou biomasou stromu boli výrazne vyššie pri smreku než buku. Na úrovni porastu mala smrečina vyššie hodnoty indexu listovej plochy, t. j. LAI (18,64 m2.m−2 v porovnaní s bučinou (12,77 m2.m−2. Kým biomasa asimilačných orgánov bola 4,6-krát väčšia v smrekovom než v bukovom poraste, biomasa drevných časti bola porovnateľná v obidvoch porastoch. Tieto kontrasty naznačujú výrazne odlišnú rastovú stratégiu, resp. alokáciu biomasy medzi bučinami a smrečinami v mladých štádiách

  19. THE INFLUENCE OF FLOOR QUALITY ON DAIRY COW BEHAVIOUR AND THEIR BODY CLEANLINESS VPLYV KVALITY PODLAHY NA SPRÁVANIE DOJNÍC A ICH ČISTOTU POVRCHU TELA

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    Emília KUŠNÍROVÁ

    2012-03-01

    Full Text Available The aim of this study was to evaluate the influence of floor quality on the behaviour and cleanliness of the diary cow‘s body. The analysis results show that cows housed in the section with the separated manure solids spent more time lying (41.47% and also laid less in the corridor manure (0.91% than the cows in the section with separated manure solids and the rubber mats where they were laying generally less (35.71%, they spent more time lying in the corridor manure (1.55% and in terms of preference of lying area the cows clearly preferred the separated manure solids (25.8%. Based on observations we can say that cows housed in sections of slurry solid phase were cleaner (average 6.13 points than cows in the section with the rubber and a separated manure (averagely 7.28 points. Nowadays the free housing systems with different types of litter and boxes are frequently used, while the proper littering influences the lying preferences of an animal. In practice, for the dairy cows the deepened lying boxes littered with natural materials such as sawdust, shavings, straw, dried manure and sand boxes or elevated boxes covered with a synthetic material, mattresses or mats are used.Cieľom práce bolo zhodnotiť vplyv kvality podlahy na správanie a čistotu povrchu tela dojníc. Z analýzy výsledkov vyplýva, že dojnice ustajnené v sekcii so separovaným kalom hnojovice venovali ležaniu väčšiu časť (41,47% a ležali aj menej v hnojnej chodbe (0,91% ako dojnice v sekcii so separovaným kalom hnojovice aj gumenými matracmi, kde dojnice celkovo menej ležali (35,71%, viac času ležali v hnojnej chodbe (1,55% a z hľadiska uprednostňovania ležoviska ležali jednoznačne viac na separovanom kale hnojovice (25,8%. Na základe pozorovaní možno povedať, že dojnice ustajnené v sekciách so separovaným kalom hnojovice boli čistejšie (priemerne 6,13 bodov ako dojnice v sekcii so separovaným kalom hnojovice aj gumou (priemerne 7,28 bodov. V s

  20. Nuestra Senora de la Asunción

    Directory of Open Access Journals (Sweden)

    Lina Wolff

    2016-12-01

    Full Text Available Jednom sam upoznala pisca koji je rekao da više ne može podnijeti biti pisac. Bilo je to na zabavi u Madridu i ne sjećam se kako sam tamo završila, ali zabava je bila u Ulici Ventura de la Vega pa pretpostavljam da me netko koga sam upoznala te noći odveo tamo (moji prijatelji, ako sam ih uopće imala, živjeli su na sasvim drugim mjestima. Ako si pravi pisac, ne možeš samo tako prestati pisati, rekla sam. Moram, odgovorio je. Zato što se bojim da naginjem ludilu, a onih dana kad ne naginjem ludilu naginjem nečemu još gorem. Čemu?, upitala sam. Rekao je da ne zna, ali da mora misliti na ženu i dijete i da se, što se ludila tiče, slaže s Robertom Bolanom, da je zarazno. U to vrijeme nisam puno izlazila. Tek sam se udala i loše sam govorila španjolski, sin je bio samo godinu dana star i sve sam vrijeme provodila kod kuće, osim, katkad, kad bi mi se muž vratio s puta, spustio torbe u predsoblju i pogledao me dok sam sjedila na kauču nakon cijelog dana buljenja u sapunice. Mora da sam izgledala podbuhlo i zavidno dok sam tako sjedila na kauču kad bi se on vratio kući. Uvijek je nosio kravatu i sjajno odijelo i dok bi tamo stajao sa svojom crnom, španjolskom kosom, činilo mi se da u njegovim očima vidim sve zračne luke ovog svijeta. Ali nikada nije rekao da je stan u neredu ili da izgledam kao da tjedan dana nisam oprala kosu. Rekao je: Sad je na tebi red da malo izađeš. I podigao bi našeg sina, koji bi počeo vrištati. Naš bi mu sin ispovraćao velike žute mrlje po odijelu, ali moj muž samo bi se nasmijao i izgledao sretno. Španjolci vole djecu. Dobro se odijevaju i opušteni su, ta mi se kombinacija oduvijek sviđala.

  1. Induced mutation for the improvement of soybean (Glycine max L.)

    International Nuclear Information System (INIS)

    Asencion, A.B.; Lapade, A.G.; Grafia, A.O.; Barrida, A.C.; Veluz, A.M.; Marbella, L.J.

    2004-01-01

    A study on the use of gamma radiation in the induction of mutations in eight varieties of soybean was conducted. The radiosensitivity of the seeds of both local and introduced soybean varieties was determined. The effects of gamma radiation in the M1 generation were evaluated. Percentage germination was not affected by doses of 200 and 250 Gy gamma radiation in all the eight soybean varieties. No significant differences in seedling height were observed at 200 Gy and the control except for the 250 Gy in BPI-Sy4, PSB-Sy4 and PSB-Sy5. In the Vietnamese varieties, significant differences in seedling height were obtained in doses of 200, 250 Gy and the control except for the variety AKO 6. There was significant difference in plant height of mature plants between the control and treatment dose of 250 Gy in varieties DT 95 and AKO 6. Likewise, significant differences in mature plant height were noted between the control and those at 250 Gy in local varieties BPI-Sy4, PSB-Sy5 and NSIC-Sy8. The number of days to flower was not affected by gamma radiation in both the local and introduced varieties. There were significant differences in the number of pods per plant between the control and a low dose of 200 Gy in Vietnamese variety DT 96 and the local varieties PSB-Sy4, PSB-Sy5 and NSIC-Sy8. The 3 types of chlorophyll mutation induced by gamma rays in the local varieties were: chlorina, striatia,and spotted yellow. Only chlorina mutant was induced in the introduced varieties. Desirable mutants that are early and high yielding were selected. Results of the drought tolerance tests indicated that the number of days to flowering of the control and 8 varieties was not affected by the duration of irrigation withdrawals 20,30,40 and 50 days after planting. Significant differences in seed weight among the different varieties were noted only in 20 and 30 day irrigation withdrawal treatment. When the effects of the different treatments were analyzed on a per variety bases, some of the

  2. Primjena spektrometrijskih metoda u analizi metalurških uzoraka

    Directory of Open Access Journals (Sweden)

    Anita Štrkalj

    2016-07-01

    Full Text Available Instrumentalne metode analize nezamjenjive su u znanstvenim istraživanjima, a sve više i u praksi gdje se zahtijeva što brže dobivanje rezultata, kao i što veća točnost. U metalurškoj praksi već se dulji niz godina primjenjuju spektrometrijske metode analize i to najčešće optička emisijska spektrometrija s izravnim očitanjem. Međutim koncentracija pojedinih legirnih elemenata u suvremenim metalnim materijalima vrlo je niska, često niža od granice detekcije optičkih emisijskih spektrometara s izravnim očitanjem. U ovom radu određivana je koncentracija bora u nodularnom lijevu primjenom optičke emisijske spektrometrije s izravnim očitanjem (OES, optičke emisijske spektrometrije s induktivno spregnutom plazmom (ICP-OES te atomske apsorpcijske spektrometrije s grafitnom tehnikom (AAS-GF. Dobiveni rezultati pokazali su da se optička emisijska spektrometrija s izravnim očitanjem i optička emisijska spektrometrija s induktivno spregnutom plazmom mogu primijeniti za određivanje bora u ispitivanim uzorcima (tablica 1. Ako se zahtijeva vrlo točna analiza, a posebno ako se radi o vrlo niskim koncentracijama, optička emisijska spektrometrija s induktivno spregnutom plazmom pogodnija je metoda, uz uvjet da su uzorci pravilno pripremljeni. Atomska apsorpcijska spektrometrija s grafitnom tehnikom nije pogodna za određivanje bora u uzorcima ovog tipa. Tijekom provođenja analize dodatna pažnja usmjerena je na eliminaciju negativnog utjecaja grafitne kivete na rezultat analize. Osim toga, u radu je praćen utjecaj načina otapanja uzoraka na rezultate analize bora spomenutim metodama. Rezultati su pokazali da pažljiva priprema uzoraka u zatvorenom sustavu pridonosi točnijem rezultatu analize.

  3. Afferent input selects NMDA receptor subtype to determine the persistency of hippocampal LTP in freely behaving mice

    Directory of Open Access Journals (Sweden)

    Jesús Javier Ballesteros

    2016-10-01

    Full Text Available The glutamatergic N-methyl-D-aspartate receptor (NMDAR is critically involved in many forms of hippocampus-dependent memory that may be enabled by synaptic plasticity. Behavioral studies with NMDAR antagonists and NMDAR subunit (GluN2 mutants revealed distinct contributions from GluN2A- and GluN2B-containing NMDARs to rapidly and slowly acquired memory performance. Furthermore, studies of synaptic plasticity, in genetically modified mice in vitro, suggest that GluN2A and GluN2B may contribute in different ways to the induction and longevity of synaptic plasticity. In contrast to the hippocampal slice preparation, in behaving mice, the afferent frequencies that induce synaptic plasticity are very restricted and specific. In fact, it is the stimulus pattern, and not variations in afferent frequency that determine the longevity of long-term potentiation (LTP. Here, we explored the contribution of GluN2A and GluN2B to LTP of differing magnitudes and persistencies in freely behaving mice. We applied differing high-frequency stimulation (HFS patterns at 100 Hz to the hippocampal CA1 region, to induce NMDAR-dependent LTP in wild-type (WT mice, that endured for 24h (late (L-LTP. In GluN2A-KO mice, E-LTP (HFS, 50 pulses was significantly reduced in magnitude and duration, whereas LTP (HFS, 2 x 50 pulses and L-LTP (HFS, 4 x 50 pulses were unaffected compared to responses in WT animals. By contrast, pharmacological antagonism of GluN2B in WT had no effect on E-LTP but significantly prevented LTP. E- LTP and LTP were significantly impaired by GluN2B antagonism in GluN2A-KO mice. These data indicate that the pattern of afferent stimulation is decisive for the recruitment of distinct GluN2A and GluN2B signaling pathways that in turn determine the persistency of hippocampal LTP. Whereas brief bursts of patterned stimulation preferentially recruit GluN2A and lead to weak and short-lived forms of LTP, prolonged, more intense, afferent activation recruits GluN2B

  4. Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice.

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    Che-Chung Yeh

    Full Text Available We have hypothesized that post-infarction cardiac remodeling can be influenced by shifts in the balance between intracellular mediators of "pathologic" and "physiologic" hypertrophy. Although alpha1 adrenergic receptors (alpha1-ARs mediate pro-adaptive hypertrophy during pressure overload, little is known about their role or downstream mediators after myocardial infarction.We performed loss-of-function experiments via coronary ligation in alpha1A-AR knockout (AKO mice. Post-myocardial infarction (MI remodeling was evaluated via echocardiography, quantitative reverse transcription-polymerase chain reaction (RT-PCR analysis of cardiac fetal gene expression, histologic analysis of myocyte size, post-MI fibrosis and apoptosis, and Western blot analysis of apoptotic regulators.Alpha1A-AR knockout paradoxically increased post-MI hypertrophy compared to wild type controls (WT, but also increased ventricular dilatation, fibrosis, apoptosis, and 4-week post-MI mortality (64% in AKO vs. 25% in WT, P = 0.02, suggesting a shift toward greater pathologic hypertrophy in the absence of pro-adaptive alpha1A effects. alpha1A-AR knockout increased phospho-p38 levels in the pre-MI myocardium compared to WT (0.55 ± 0.16 vs. 0.03 ± 0.01, P<0.05 but decreased phospho-ERK1/2 post-MI (0.49 ± 0.35 arbitrary units vs. 1.55 ± 0.43 in WT, P<0.05. Furthermore, expression of pro-apoptotic factor Bax was increased (1.19 ± 0.15 vs. 0.78 ± 0.08, P<0.05 and expression of anti-apoptotic factors Bcl2 was decreased (0.26 ± 0.01 vs. 0.55 ± 0.06, P<0.01 compared to WT.Alpha1A-AR provides an important counterbalance to pathologic pathways during post-MI remodeling that may be mediated through ERK1/2 signaling; these observations provide support for further development of an alpha1A-AR/ERK-based molecular intervention for this chronic, often fatal disease.

  5. Slovak brown coals as a feedstock for the active coke production

    Directory of Open Access Journals (Sweden)

    Sobolewski Aleksander

    1998-09-01

    Full Text Available V èlánku sa venuje pozornos možnostiam výroby aktívneho koksu zo slovenského hnedého uhlia Bane Cíge¾. Príprava aktívneho koksu bola uskutoènená v laboratórnych podmienkach a v poloprevádzke. Surové uhlie sa podrobilo vysokoteplotnej pyrolýze v retorte s pevným roštom, v klasickej rotaènej peci, ako aj vo fluidnom reaktore. Následne boli urèované adsorpèné charakteristiky získaného aktívneho koksu, ktoré sa porovnávali s charakteristikami komerène vyrábaného koksu. V príspevku sa taktiež diskutujú možnosti aplikácie pripraveného aktívneho koksu v technológiách ochrany životného prostredia.

  6. Reducing urban diffuse pollution and surface water flooding using retrofit street trees

    Science.gov (United States)

    Rothwell, James; Stringer, Pete; Causer, Katherine; Ryan, Matt; Mangan, Steve; Appleton, Ian; Savage, Mike

    2016-04-01

    Nature-based solutions for the management of urban stormwater have been growing in popularity, but there is a lack of empirical performance data for field-scale installations, especially in a UK context. To address this deficiency, a novel retrofit street tree demonstration project was commissioned in the City of Salford, near Manchester (UK). Three fifteen year-old London Plane trees were planted within a large roadside tree trench on an urban residential street. The DeepRoot Silvia Cell modular suspended pavement system was used to maximise soil volume, avoid compaction and support large tree growth. Road runoff is directed to the tree trench via AKO Slot Kerbs. Water is then distributed evenly throughout the whole system via a perforated pipe. Excess water is conveyed out of the system via an underdrain, which is subsequently connected to the sewer network. The tree trench is lined with an impermeable membrane. Access chambers are positioned on the inflow and outflow of the tree trench to facilitate hydrological and water quality monitoring. Installation was completed in autumn 2015 and monitoring will be conducted over a three year period. This paper will provide an overview of the installation process and present initial results on the pollutant removal performance and hydrological functioning of the system.

  7. Impact of industrial structure and soil exposure on the regional variations in pulmonary nontuberculous mycobacterial disease prevalence.

    Science.gov (United States)

    Hamada, Satoshi; Ito, Yutaka; Hirai, Toyohiro; Murase, Kimihiko; Tsuji, Takahiro; Fujita, Kohei; Mio, Tadashi; Maekawa, Koichi; Fujii, Takashi; Ono, Shigeki; Nishimura, Takashi; Hayashi, Akihiko; Komori, Toshiaki; Fujita, Naohisa; Niimi, Akio; Ichiyama, Satoshi; Chin, Kazuo; Mishima, Michiaki

    2016-06-01

    The prevalence of pulmonary nontuberculous mycobacterial (pNTM) disease, including Mycobacterium avium complex (MAC), varies widely according to geographic region. However, the factors that influence regional variations in pNTM disease prevalence remain unknown. This study was undertaken to examine whether environmental or occupational factors or host traits could influence regional variations in pNTM disease prevalence. We collected laboratory data on pulmonary tuberculosis (pTB) and pNTM from two hospitals in the West Harima area of Japan and five hospitals in Kyoto City, Japan from 2012 to 2013. We estimated microbiological pNTM disease prevalence by multiplying all pTB cases in each area with the ratio of pNTM cases and pTB cases at the survey hospitals in each area. We administered a standardized questionnaire to 52 patients and 120 patients with pulmonary MAC (pMAC) disease at Ako City Hospital and Kyoto University Hospital, respectively. The estimated prevalence of microbiological pNTM disease in the West Harima area (85.4/100,000 population-years) was significantly higher than that observed in Kyoto City (23.6/100,000 population-years; pEnvironmental factors, both industrial structures associated with occupational dust and environmental soil exposure, could influence the regional variations in pNTM disease prevalence. Copyright © 2016 Asian-African Society for Mycobacteriology. Published by Elsevier Ltd. All rights reserved.

  8. Tvorba IMS aplikací

    OpenAIRE

    Nagy, Ľuboš

    2009-01-01

    Diplomová práca sa zaoberá základnou štúdiou architektúry IMS a možnosťami vývoju aplikácie v nej. V prvej časti práce je popísaná generická architektúra IMS ako vrstvový model rozdelený na štyri logické vrstvy s popisom rozhraní a hlavných entít. Ďalej je znázornená a vysvetlená architektúra SIP protokolu s jej prvkami, ktorý je hlavným signalizačným protokolom v IMS. Vzhžadom na povahu zadania v prípade SIP protokolu sú popísané aj jeho metódy. V poslednej teoretickej časti práce sú spomenu...

  9. Obligations Related to the Transportation of pet Animals (Eu Legislation / Povinnosti Súvisiace S Prepravou Spoločenských Zvierat (Európska Legislatíva

    Directory of Open Access Journals (Sweden)

    Pavlíková Barbara

    2015-06-01

    Full Text Available Prispevok sa zaobera otazkou, ktoru často riešia majitelia spoločenskych zvierat vo všetkych členskych štatoch EU. Poskytuje bližši pohľad na povinnosti spojene s cestovanim so zvieraťom medzi členskymi štatmi, alebo medzi členskym štatom a treťou - nečlenskou krajinou. Zameriava sa na nekomerčnu prepravu, ako je napriklad dovolenka, vylet a podobne. Praca prostrednictvom syntezy, analyzy a porovnania ponuka prehľad zakladnych legislativnych aktov v predmetnej oblasti. Venuje sa tiež otazke tzv. pet pasu, najdoležitejšieho identifikačneho dokladu, vyžadovaneho pre spoločenske zvierata na uzemi EU. Možno v nej najsť aj definicie najčastejšie použivanej terminologie.

  10. Měření na asynchronním motoru

    OpenAIRE

    Svetlík, Martin

    2009-01-01

    Práca pojednáva o spôsoboch merania jednotlivých druhov charakteristík asynchrónnych motorov a je rozdelená na tri hlavné kapitoly. Prvá kapitola nás zbežne oboznamuje s históriou asynchrónnych motorov a smerovaním práce. Druhá kapitola sa dôklane venuje možnostiam typových skúšiek tohto druhu pohonu. V tretej kapitole sú uvedené výsledky uskutočnených meraní na dvoch motoroch ďalej označovaných ako typ AOM090L02-016 (ktorý je vybavený jednovrstvým vinutím) a typ AOM090L02-017 (ktorý je vybav...

  11. Mikroprogram pre riadenie procesu spájania operandov v architektúre DF KPI

    Directory of Open Access Journals (Sweden)

    Norbert Ádám

    2013-12-01

    Full Text Available V článku uvedená architektúra je založená na výpočtovom modeli „data flow“, v ktorom riadenie výpočtu je založené na spracovaní toku dát. Základným prvkom DF architektúry je koordinačný procesor (CP, ktorý je zodpovedný za riadenie a organizáciu vykonávania inštrukcií. Štruktúrna organizácia CP je navrhnutá ako dynamický multifunkčný systém. Pri vykonávaní operácií môže CP prechádzať rôznymi stavmi, v dôsledku čoho táto jednotka predstavuje dynamický prúdový systém. Prechod a poradie prechodu medzi jednotlivými stavmi CP je podmienený typom spracovaného operátora pri interpretovaní prúdu operandov. Z možných typov operátorov, článok uvádza mikroprogramové riadenie pre jednovstupové operátory.

  12. Simulace stínění ionizujícího záření programem MCNP

    OpenAIRE

    Konček, Róbert

    2015-01-01

    Žiarenie je definované ako ionizujúce, ak má dostatok energie na vytrhnutie elektrónov z atómov alebo molekúl, počas jeho prechodu látkovým prostredím. Z tejto schopnosti vyplýva jeho potenciál pôsobiť škodlivo na tkanivá živých organizmov. Tienenie ionizujúceho žiarenia je preto disciplína s veľkou praktickou dôležitosťou. Táto práca nadväzuje na autorovu predchádzajúcu prácu v tejto oblasti a rozširuje ju diskutovaním teoretických a praktických problémov pokročilých výpočtov tienenia. V teo...

  13. Planetary Systems and the Origins of Life

    Science.gov (United States)

    Pudritz, Ralph; Higgs, Paul; Stone, Jonathon

    2013-01-01

    Preface; Part I. Planetary Systems and the Origins of Life: 1. Observations of extrasolar planetary systems Shay Zucker; 2. The atmospheres of extrasolar planets L. Jeremy Richardson and Sara Seager; 3. Terrestrial planet formation Edward Thommes; 4. Protoplanetary disks, amino acids and the genetic code Paul Higgs and Ralph Pudritz; 5. Emergent phenomena in biology: the origin of cellular life David Deamer; Part II. Life on Earth: 6. Extremophiles: defining the envelope for the search for life in the Universe Lynn Rothschild; 7. Hyperthermophilic life on Earth - and on Mars? Karl Stetter; 8. Phylogenomics: how far back in the past can we go? Henner Brinkmann, Denis Baurain and Hervé Philippe; 9. Horizontal gene transfer, gene histories and the root of the tree of life Olga Zhaxybayeva and J. Peter Gogarten; 10. Evolutionary innovation versus ecological incumbency Adolf Seilacher; 11. Gradual origins for the Metazoans Alexandra Pontefract and Jonathan Stone; Part III. Life in the Solar System?: 12. The search for life on Mars Chris McKay; 13. Life in the dark dune spots of Mars: a testable hypothesis Eörs Szathmary, Tibor Ganti, Tamas Pocs, Andras Horvath, Akos Kereszturi, Szaniszlo Berzci and Andras Sik; 14. Titan: a new astrobiological vision from the Cassini-Huygens data François Raulin; 15. Europa, the Ocean Moon: tides, permeable ice, and life Richard Greenberg; Index.

  14. Výroba dětské stoličky pro stomatologickou ordinaci s využitím metody Fused Deposition Modeling

    OpenAIRE

    Kyseľová, Barbora

    2013-01-01

    Bakalárska práca popisuje tvorbu návrhu modelu detskej stoličky v tvare ľudského zuba využiteľnou v stomatologickej ordinácii. Práca je radená do nadväzujúcich oddielov tak, ako bolo pri návrhu postupované. V úvode práce je venovaná pozornosť vytvoreniu fyzického modelu, ďalej predostrie využitie ručného 3D skenera a v rámci digitalizácie následne podloží nevyhnutnú úpravu dát získanú po skenovaní. Práca sa tiež zaoberá výrobou modelu stoličky, ktorá je realizovaná na 3D tlačiarni uPrint s vy...

  15. 2011 Einstein Fellows Chosen

    Science.gov (United States)

    2011-03-01

    ASA has announced the selection of the 2011 Einstein Fellows who will conduct research related to NASA's Physics of the Cosmos program, which aims to expand our knowledge of the origin, evolution, and fate of the Universe. The Einstein Fellowship provides support to the awardees for three years, and the Fellows may pursue their research at a host university or research center of their choosing in the United States. The new Fellows will begin their programs in the fall of 2011. The new Einstein Fellows and their host institutions are listed below: * Akos Bogdan (Smithsonian Astrophysical Observatory, Cambridge, Mass.) * Samuel Gralla (University of Maryland, College Park, Md.) * Philip Hopkins (University of California at Berkeley) * Matthew Kunz (Princeton University, Princeton, N.J.) * Laura Lopez (Massachusetts Institute of Technology, Cambridge, Mass.) * Amy Reines (National Radio Astronomy Observatory, Charlottesville, Virg.) * Rubens Reis (University of Michigan, Ann Arbor) * Ken Shen (Lawrence Berkeley National Laboratory, Berkeley, Calif.) * Jennifer Siegal-Gaskins (California Institute of Technology, Pasadena) * Lorenzo Sironi (Harvard University, Cambridge, Mass.) NASA has two other astrophysics theme-based fellowship programs: the Sagan Fellowship Program, which supports research into exoplanet exploration, and the Hubble Fellowship Program, which supports research into cosmic origins. More information on the Einstein Fellowships can be found at: http://cxc.harvard.edu/fellows/

  16. Conservation education in Madagascar: three case studies in the biologically diverse island-continent.

    Science.gov (United States)

    Dolins, Francine L; Jolly, Alison; Rasamimanana, Hantanirina; Ratsimbazafy, Jonah; Feistner, Anna T C; Ravoavy, Florent

    2010-05-01

    Few Malagasy children and adults are aware of the rare and unique fauna and flora indigenous to their island-continent, including flagship lemur species. Even the Malagasy ancestral proverbs never mentioned lemurs, but these same proverbs talked about the now extinct hippopotamus. Madagascar's geography, history, and economic constraints contribute to severe biodiversity loss. Deforestation on Madagascar is reported to be over 100,000 ha/year, with only 10-15% of the island retaining natural forest [Green & Sussman, 1990]. Educating children, teacher-training, and community projects about environmental and conservation efforts to protect the remaining natural habitats of endangered lemur species provide a basis for long-term changes in attitudes and practices. Case studies of three conservation education projects located in different geographical regions of Madagascar, Centre ValBio, Madagacar Wildlife Conservation Alaotra Comic Book Project, and The Ako Book Project, are presented together with their ongoing stages of development, assessment, and outcomes. We argue that while nongovernmental organizational efforts are and will be very important, the Ministry of Education urgently needs to incorporate biodiversity education in the curriculum at all levels, from primary school to university. (c) 2009 Wiley-Liss, Inc.

  17. Resposta taquicárdica e controle autonômico no exercício físico em modelo genético de insuficiência cardíaca Tachycardic response and autonomic control in physical exercise in genetic model of cardiac insufficiency

    Directory of Open Access Journals (Sweden)

    Telma F. Cunha

    2009-08-01

    Full Text Available O aumento da atividade nervosa simpática e a taquicardia em repouso ou durante esforços físicos estão associados ao aumento da morbimortalidade, mesmo na ausência de sinais clínicos de doença cardíaca. Sabendo-se da importância dos receptores α2A/α2C-adrenérgicos na modulação da atividade nervosa e frequência cardíaca (FC, o presente trabalho utiliza um modelo genético de cardiomiopatia induzida por excesso de catecolaminas circulantes baseado na inativação gênica dos receptores α2A/α2C-adrenérgicos em camundongos (α2A/α2CKO para verificar a resposta da FC ao exercício físico (EF, assim como o controle simpatovagal da FC ao EF. Testou-se a hipótese de que haveria resposta taquicárdica exacerbada durante o EF nos camundongos α2A/α2CKO mesmo quando a função cardíaca ainda estivesse preservada em repouso, sendo o receptor α2A-adrenérgico o principal responsável por essa resposta. Camundongos machos da linhagem C57Bl6J, controle (CO e com inativação gênica para os receptores α2A (α2AKO, α2C α2CKO e α2A/α2CKO foram submetidos a um teste de tolerância ao esforço físico. Outros dois grupos de camundongos, CO e α2A/α2CKO, foram submetidos ao bloqueio farmacológico dos receptores muscarínicos e β-adrenérgicos e ao EF progressivo para se avaliar a contribuição simpatovagal para a taquicardia de EF. Observou-se intolerância ao esforço físico (1.220 ± 18 e 1.460 ± 34 vs. 2.630 ± 42m, respectivamente e maior taquicardia ao EF (765 ± 16 e 792 ± 13 vs. 603 ± 18bpm, respectivamente nos camundongos α2AKO e α2A/α2CKO vs. CO. Além disso, o balanço autonômico estava alterado nos camundongos α2A/α2CKO pela hiperatividade simpática e menor efeito vagal cardíaco. Esses resultados demonstram a importância dos receptores α2A/α2C-adrenérgicos no controle autonômico não só no repouso, mas também durante o EF, sendo o receptor α2A-adrenérgico o responsável pela hiperatividade simp

  18. Uticaj mesta ugradnje inercijalnog mernog bloka i akcelerometara na grešku u određivanju pozicije aviona / Size effect of the inertial measurement unit and inside IMU accelerometers on aircraft position error

    Directory of Open Access Journals (Sweden)

    Slobodan Janićijević

    2003-03-01

    Full Text Available U ovom članku analiziran je uticaj mesta ugradnje inercijalnog mernog bloka (IMB u avionu i mesta ugradnje akcelerometara u IMB na tačnost određivanja pozicije pomoću bes-platformskog inercijalnog navigacijskog sistema (BINS. Pokazano je da se ovi uticaji ne mogu uvek zanemariti. Izračunata je ukupna greška u određivanju pozicije aviona ako se IMB ugrađuje van centra rotacije aviona, a akcelerometri van centra IMB. Predložena je optimalna orijentacija akcelerometara u IMB-u, kako bi se minimizirao uticaj ugradnje akcelerometara van centra IMB na tačnost određivanja pozicije aviona. Predložen je i način kompenzacije greške. / This paper analyzes the mounting offset size effect of the inertial measurement unit (IMU in aircraft and accelerometers mounting offset size effect in the IMU on the accuracy of strap down inertial navigation system (SDINS. It is also shown that these effects cannot be always neglected. The total size effect error for the IMU has been the computed. An accelerometers optimum orientation inside the IMU has been proposed to minimize size effects on the accuracy of navigation parameters. A manner to compensate these size effects has been proposed as well.

  19. Elementi koji diferenciraju ugovor o spašavanju od ugovora o tegljenju : (prikaz presude

    Directory of Open Access Journals (Sweden)

    Vesna Skorupan Wolff

    2016-07-01

    Full Text Available Brod kojem su se zaustavili porivni strojevi, a uslijed toga vjetar i morska struja nosili su ga prema obali, zatražio je uslugu tegljenja. Između stranaka je sporno radi li se u konkretnom slučaju o ugovoru o tegljenju ili ugovoru o spašavanju. Spašavanje je svaka djelatnosti kojoj je svrha spašavanje osoba, brodova i stvari s tih brodova. Bitan element pojma spašavanja jest da se osoba, odnosno stvar koja se spašava nalazi u opasnosti (opasnost po život osoba, odnosno propast stvari. Pod spašavanjem se podrazumijeva i pružanje pomoći. Ako je pomoć pružena tegljenjem, to ne znači da se radi o pravnom poslu tegljenja. U konkretnom slučaju u pitanju nije bio komercijalni posao tegljenja već posao spašavanja.

  20. Empowering student leaders to nurture the first year experience through cross-cultural diversity. A Practice Report Nāu te raurau, Nāku te raurau, ka ora ai te iwi

    Directory of Open Access Journals (Sweden)

    Deborah Laurs

    2013-08-01

    Full Text Available Victoria University offers a number of peer-support and mentoring programs for first-year students, including Te Pūtahi Atawahi (mentoring and holistic support for Māori and Pasifika students, PASS (Peer Assisted Study Support and Campus Coaches (Orientation Week guides. In the past, despite having similar goals of providing peer-support to foster a sense of community, such programs have operated in isolation. However, a recent initiative has seen the development of a core leadership training module, jointly designed and delivered by staff from Te Pūtahi Atawhai and Student Learning Support. Seeking to equip student-leaders with an understanding of some of the holistic Māori values, Kotahitanga (unity, Ako (teaching and learning, Manaakitanga (empathy/hospitality, Whakamana (respect, Whakanui (acknowledging success, Whakawhanaungatanga (building strong networks and Rangatiratanga (ability to bring groups together/Self-direction, this core training offers the potential to strengthen Treaty of Waitangi relationships and nurture inter-cultural awareness, developing a pan-university sense of belongingness in the process. 

  1. Selected Issues of Legislation with regard to Operating Pharmacies in the Slovak Republic / Vybrané problémy právnej úpravy prevádzkovania lekární v podmienkach Slovenskej republiky

    Directory of Open Access Journals (Sweden)

    Capandová Petra

    2015-06-01

    Full Text Available Medzi základné práva a slobody, upravené v druhej hlave Ústavy Slovenskej republiky patrí aj právo na ochranu zdravia, bezplatnú zdravotnú starostlivosť na základe zdravotného poistenia, právo na zdravotnícke pomôcky za zákonom stanovených podmienok. Tieto práva sú garantované v ustanovení Čl. 40 Ústavy Slovenskej republiky v rámci ekonomických, sociálnych a kultúrnych práv a vzťahujú sa na každú fyzickú osobu, t. j. na človeka. Keďže sú tieto práva považované za ľudské práva v zmysle medzinárodného práva, sú garantované aj v mnohostranných medzinárodných zmluvách, ktorých signatárom je aj Slovenská republika, ako napríklad Medzinárodný pakt o hospodárskych, sociálnych a kultúrnych právach. Právna úprava prevádzkovania lekární v Slovenskej republike zahŕňa široké spektrum otázok a je pomerne rozsiahla. Snahou zákonodarcu bolo nastaviť také pravidlá, ktoré by stransparentnili a zjednodušili právne prostredie v tomto sektore. V niektorých oblastiach sú pravidlá dané legislatívou Európskej únie a slovenský právny poriadok ich iba prevzal. Najdôležitejším prvokom v tejto sfére, ktorý nie je priamo upravovaný legislatívou EÚ, je poskytovanie lekárenskej starostlivosti a využívanie systému verejného zdravotného poistenia v tejto oblasti. Hlavným cieľom príspevku je poukázať na vybrané problémy, ktoré sa spájajú s postavením prevádzkovateľa lekárne a jeho povinnosťami, ktoré mu vyplývajú zo zákona o liekoch a s ktorými sa musí ako prevádzkovateľ lekárne vysporiadať. Táto oblasť podnikania je pomerne prísne regulovaná a preto je potrebné byť oboznámený s príslušnými právnymi predpismi. Príspevok z právno-teoretického hľadiska rieši viaceré otázky upravené v zákone o liekoch, či vyhláške o správnej lekárenskej praxi.

  2. Inter- and intra-annual dynamics of height increment in young beech and spruce stands in relation to tree size and weather conditions

    Directory of Open Access Journals (Sweden)

    Konôpka Bohdan

    2014-03-01

    Full Text Available Počas rokov 2009-2013 sme sledovali sezónnu dynamiku výškového prírastku, ako aj celoročný výškový prírastok v bukových a smrekových mladinách rastúcich na totožnom stanovišti. Výsledky naznačili, že medziročné zmeny základných porastových charakteristík, a to najmä hustota porastu, boli výraznejšie v smrečine než v bučine. Omnoho vyššia stromová mortalita v smrečine sa vysvetlila nižšou intenzitou svetla pod korunovou vrstvou smrekov, resp. vyššou toleranciou buka na zatienenie. Veľké medzidruhové rozdiely sa zaznamenali v „načasovaní“ výškového prírastku. Konkrétne výškový prírastok bukov začal každoročne skôr ako výškový prírastok smrekov. Ďalej, terminál smrekov rástol dlhšie (približne 70 dní v porovnaní s bukmi (45 dní. Porovnanie priebehov výškových prírastkov vzhľadom na prostredie naznačilo, že principiálny vplyv mala globálna radiácia. V bučine bola maximálna intenzita výškového prírastku počas dní s maximálnou úrovňou globálnej radiácia, a to v rokoch 2009 a 2011, zároveň pokles intenzity sa objavil simultánne s poklesom globálnej radiácie počas roku 2012. V smrečine intenzita výškového prírastku predstavovala jednovrcholovú krivku - s najvyššou intenzitou prírastku v dňoch maximálnych hodnôt globálnej radiácie počas 2009 a 2012. Na druhej strane sa zaznamenal dvojvrcholový výskyt maxím intenzity výškového prírastku smrekov v 2010 a 2011. Tento jav súvisel s dočasným poklesom globálnej radiácie v týchto rokoch. Medzidruhové rozdiely v načasovaní výškového prírastku môžu mať relevanciu v prípade výskytu nepriaznivých poveternostných podmienok. Napríklad pri epizódach sucha v polovici vegetačného obdobia, keďže výškový prírastok je vtedy už ukončený pri bukoch avšak na smrekoch ešte prebieha

  3. Lietuvių kalbos postpoziciniai vietininkai

    Directory of Open Access Journals (Sweden)

    Zigmas Zinkevičius

    2011-12-01

    Full Text Available POSTPOSITIONAL LOCATIVES IN LITHUANIANSummaryThe paper argues that postpositional locatives in Lithuanian (inessive, illative, adessive, allative are not formations of the same epoch, but rather they were formed at different times; the pro­cess of their formation must have been long and continued right up to the appearance of the first Lithuanian printed book when the case-forms fell into a decline. First came singular forms, next — plural forms. More complicated and protracted was the development of inessive and adessive case-forms.Ā- and ē-stem sg. iness. and ill. forms (e. g. šakojè, žẽmėje, šakõn, žẽmėn are considered to be the oldest. The other sg. ill. and particularly sg. iness. forms are products of later development, as they are, as a rule, constructed in the above-mentioned pattern. The paper gives a detailed analysis of the case-forms and on the basis of the analysis it argues that the singular of all postpositional locatives had already been formed and become stable by the beginning of the period of writing -nothing of the kind can be said of the plural. Only illative and allative possessed then stable plural forms.The development of pl. iness. and adess. forms was hindered by the residual ancient Indo-European locative in -su. The centre of the author's attention, however, is the interrelationship of the case-forms and particularly the origin and development of pl. iness. and adess. case-forms.On the basis of a detailed analysis of the old writings, the author argues that the pl. iness. šakosa derives not from šakose, as is generally assumed, but it presents by itself a transformed version of the older form šakosu. The form šakose is to be derived not from the pl. acc. * šakā́s + *éп, but it should be treated as a transform of šakosu от šakosa in -e from the sg. inessive, cf. šakojè. Pl. adess. šakosumpi is not a transform of šakosempi, as is generally assumed, but the older variant of the

  4. Dora Maček: Nijanse modrog u pjesmama Susanne Jorn

    Directory of Open Access Journals (Sweden)

    Susanne Jorn

    2012-06-01

    Full Text Available Pjesništvo Susanne Jorn intimno je s mnogo kratkih pjesama koje često izražavaju osjećaje, atmosferu i dojmove. Tu su osobna viđenja prirode i ljudi, doživljena, mogli bismo reći, na slikarski način. Boje su gotovo redoviti sastavni dio tih doživljaja i kao na slikama, stvaraju dramatičnu ili smirenu atmosferu. One su izraz prirode koja okružuje pjesnikinju, ali su i izraz osjećaja i duševnih stanja. To se jasno pokazuje u zbirci Ne sada već sad, čiji je okvir paleta plavih boja. Druga scena njezine poezije sličice su iz japanskog života i japanske umjetnosti i pjesništva, koje mnogo puta prenosi u svoju dansku okolinu. U zbirci Ne sada već sad mnoge su pjesme prizori iz Danske ili Tokija, ali i drugih krajeva svijeta gdje je boravila. Ipak, njezino je pjesništvo prije svega vezano uz nordijsko nebo, zemlju i kulturu te sjećanja na oca (poznatog danskog likovnog umjetnika Asgera Jorna, koji je u svojim djelima spajao različite vrste umjetnosti. Asger Jorn bio je član poznate transnacionalne udruge CoBrA, koja je djelovala početkom 1950-ih godina. U mnoge se pjesme određenih osjećaja i ozračja skladno uklapaju i japanski i danski krajolici te japanski i, ako tako možemo reći, nordijski pjesnički izraz. Unatoč vrlo intimnoj poeziji, kao i većina skandinavskih pjesnika i pjesnikinja, Susanne Jorn osjetljiva je na sudbu današnjeg čovjeka bilo gdje u svijetu i ona nalazi značajno mjesto u njezinu pjesništvu.

  5. Informacioni sistemi održavanja u Vojsci Srbije i Crne Gore i okruženju / Informational systems of maintenance in the Army of Serbia and Montenegro and environment

    Directory of Open Access Journals (Sweden)

    Saša Veselinović

    2005-05-01

    Full Text Available Efikasno upravljanje sistemom održavanja moguće je samo ako vrh upravljačke strukture ima pravovremene i kvalitetne informacije o stanju sistema. Ovakve informacije moguće je obezbediti primenom odgovarajućeg automatizovanog informacionog sistema. U svetu postoje programski paketi za automatizaciju informacionog sistema održavanja pomoću kojih se vode podaci o stanju sredstava, toku održavanja, troškovima, nabavci rezervnih delova, a pojedini sistemi omogućavaju i statističko predviđanje otkaza. Informacioni sistem održavanja koji funkcioniše u Vojsci Srbije i Crne Gore je manuelan, a uspostavljen je pre uvođenja računara u operativnu upotrebu. Tokom eksploatacije sistem je više puta dograđivan i prilagođavan za automatizaciju. Aplikacije koje su trenutno u funkciji u pojedinim jedinicama nisu sistemsko rešenje već pokušaji entuzijasta da olakšaju deo aktivnosti u svom radu, a vezane su prvenstveno za izradu izveštaja. / Management of system of maintenance on effective -way is possible only if management has opportune and quality information about state of system. Providing opportune and quality information is possible only with appropriate automotive information system. In The World exist many programs for automation information systems of maintenance, -which observe a data about condition of equipments, flow of maintenance, a costs, purchasing of pans, and some of them provide statistical predicting of failures. Information system of maintenance, which functioning in Military forces of State Union of Serbia and Montenegro, is manual and established before implementation of personal computer in operative use, but through couple projects accomplished for automation. A program, which are in use, in some units, aren't system solution, then attempting group enthusiastic people to make easiest some activity in his work on making reports.

  6. Adult-onset deficiency of acyl CoA:monoacylglycerol acyltransferase 2 protects mice from diet-induced obesity and glucose intolerance.

    Science.gov (United States)

    Banh, Taylor; Nelson, David W; Gao, Yu; Huang, Ting-Ni; Yen, Mei-I; Yen, Chi-Liang E

    2015-02-01

    Acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 catalyzes triacylglycerol (TAG) synthesis, required in intestinal fat absorption. We previously demonstrated that mice without a functional MGAT2-coding gene (Mogat2(-/-)) exhibit increased energy expenditure and resistance to obesity induced by excess calories. One critical question raised is whether lacking MGAT2 during early development is required for the metabolic phenotypes in adult mice. In this study, we found that Mogat2(-/-) pups grew slower than wild-type littermates during the suckling period. To determine whether inactivating MGAT2 in adult mice is sufficient to confer resistance to diet-induced obesity, we generated mice with an inducible Mogat2-inactivating mutation. Mice with adult-onset MGAT2 deficiency (Mogat2(AKO)) exhibited a transient decrease in food intake like Mogat2(-/-) mice when fed a high-fat diet and a moderate increase in energy expenditure after acclimatization. They gained less weight than littermate controls, but the difference was smaller than that between wild-type and Mogat2(-/-) mice. The moderate reduction in weight gain was associated with reduced hepatic TAG and improved glucose tolerance. Similar protective effects were also observed in mice that had gained weight on a high-fat diet before inactivating MGAT2. These findings suggest that adult-onset MGAT2 deficiency mitigates metabolic disorders induced by high-fat feeding and that MGAT2 modulates early postnatal nutrition and may program metabolism later in life. Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc.

  7. New Rules for Acquisition of Agricultural Land – – Case of Slovakia / Nové Pravidlá Pre Nadobúdanie Vlastníctva K Poľnohospodárskej Pôde – – Prípad Slovenska

    Directory of Open Access Journals (Sweden)

    Lazíková Jarmila

    2015-06-01

    Full Text Available Príspevok analyzuje vývoj právnej úpravy devízového zákona vo vzťahu k nadobúdaniu pôdy cudzincami vrátane nového zákona č. 140/2014 Z.z. o nadobúdaní vlastníctva poľnohospodárskeho pozemku a o zmene a doplnení niektorých zákonov, ktorý vstúpil do platnosti 1. Júna 2014. Tento zákon neobmedzuje len nadobúdanie pôdy cudzincami, ale aj občanmi Slovenska. Na základe zákona, vlastník poľnohospodárskej pôdy na Slovensku je oprávnený bez ďalších obmedzení previesť pozemok do vlastníctva (a osobe, ktorá vykonáva poľnohospodársku výrobu ako podnikanie najmenej tri roky predo dňom uzavretia zmluvy o prevode vlastníctva poľnohospodárskeho pozemku v obci, v ktorej sa poľnohospodársky pozemok nachádza, (b spoluvlastníkovi poľnohospodárskeho pozemku, (c príbuznej osobe, v prípade, že vlastníkom je fyzická osoba.

  8. Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade.

    Directory of Open Access Journals (Sweden)

    Kana Tsukuda

    Full Text Available Browning of white adipose tissue (WAT has been highlighted as a new possible therapeutic target for obesity, diabetes and lipid metabolic disorders, because WAT browning could increase energy expenditure and reduce adiposity. The new clusters of adipocytes that emerge with WAT browning have been named 'beige' or 'brite' adipocytes. Recent reports have indicated that the renin-angiotensin system (RAS plays a role in various aspects of adipose tissue physiology and dysfunction. The biological effects of angiotensin II, a major component of RAS, are mediated by two receptor subtypes, angiotensin II type 1 receptor (AT1R and type 2 receptor (AT2R. However, the functional roles of angiotensin II receptor subtypes in WAT browning have not been defined. Therefore, we examined whether deletion of angiotensin II receptor subtypes (AT1aR and AT2R may affect white-to-beige fat conversion in vivo. AT1a receptor knockout (AT1aKO mice exhibited increased appearance of multilocular lipid droplets and upregulation of thermogenic gene expression in inguinal white adipose tissue (iWAT compared to wild-type (WT mice. AT2 receptor-deleted mice did not show miniaturization of lipid droplets or alteration of thermogenic gene expression levels in iWAT. An in vitro experiment using adipose tissue-derived stem cells showed that deletion of the AT1a receptor resulted in suppression of adipocyte differentiation, with reduction in expression of thermogenic genes. These results indicate that deletion of the AT1a receptor might have some effects on the process of browning of WAT and that blockade of the AT1 receptor could be a therapeutic target for the treatment of metabolic disorders.

  9. Chuck Palahniuk: Negdje mora puknuti / S engleskog prevela Valentina Lisak

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    Chuck Palahniuk

    2011-12-01

    Full Text Available Iza zaključanih vrata zahoda u stražnjem dijelu antikvarnice Claire Upton razgovara na telefon. Glas joj odjekuje od poda i zidova: Koliko je teško provaliti nadzornu kameru? Ukrasti snimku? upita svog muža i počne plakati.U zadnjih tjedan dana bila je u tom dućanu već tri ili četiri puta. Jedan od onih gdje moraš ostaviti torbu na blagajni, inače te ne puste unutra. Moraš ostaviti i kaput, ako ima duboke, prostrane džepove. I kišobran, jer bi ljudi u nabore mogli ubacivati sitne predmete, češljeve, nakit i druge drangulije. Kraj starog blagajnika stoji sivi karton na kojem crnim markerom piše: “Ne volimo kad nas kradete!”Skidajući kaput, Claire reče: “Ja nisam lopov.”Stari blagajnik pogledom ju je odmjerio od glave do pete. Coknuo je jezikom i pitao: “Po čemu ste vi iznimka?”Za svaki ostavljeni predmet dao je Claire polovicu karte. Za torbicu hercova asa. Za kaput trefovu devetku. Za kišobran pikovu trojku.Pogledom je prešao preko Claireinih ruku, obrisa džepova na prsima i najlonki tražeći izbočine, nešto ukradeno. Iza prednjeg pulta po cijeloj su trgovini visjeli mali natpisi koji su upozoravali da je ovdje zabranjeno krasti. Kamere su nadzirale svaki prolaz, svaki kutak i sve prikazivale na malenom ekranu punom drugih ekrana. Trezor malih, crno-bijelih tv-ekrana iza blagajne gdje je sjedio starac i sve ih promatrao.

  10. Vplyv sofistikovaného hybridného Honeypotu na efektivitu architektúry systému detekcie prieniku v distribuovaných počítačových

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    Martin Chovanec

    2013-06-01

    Full Text Available Pri súčasnom vývoji technológií, rapídnom raste počítačových sietí a distribuovaných systémov, je reálne riziko útoku čoraz pravdepodobnejšie. Pre zvýšenie samotnej bezpečnosti systémov už bolo vytvorených a implementovaných množstvo riešení, ktoré mali slúžiť na detekciu a/alebo prevenciu pred samotnými útokmi. Najpoužívanejšie riešenie predstavuje použitie systému na detekciu prieniku (IDS v kooperácii s firewallom. Avšak ani IDS a ani firewall nedokážu reagovať v reálnom čase, pokiaľ sa jedná o špecifický typ útoku. Táto práca sa zaoberá detekčným mechanizmom na báze technológie Honeypot a jeho využitím v navrhovanej architektúre pre zvýšenie bezpečnosti v počítačových systémoch. Podstatou práce je poukázať na to, ako dokáže sofistikovaný hybridný Honeypot vplývať na dizajn architektúry IDS a tým zvýšiť jej efektivitu.

  11. Využitie metódy concept cartoons© na hodinách prírodovedy z pohľadu učiteľov prvého stupňa ZŠ

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    Michaela Minárechová

    2017-07-01

    Full Text Available V príspevku sa venujeme metóde concept cartoons© a jej aplikácii do vyučovania prírodovedy na I.stupni ZŠ. Okrem toho stručne opisujeme  príručku k metóde concept cartoons© pre  ZŠ, ktorú sme zostavili v rámci našej dizertačnej práce. Pre lepšie posúdenie príručky a možnosti aplikácie metódy concept cartoons© na hodinách prírodovedy sme realizovali rozhovor s tromi učiteľkami primárneho vzdelávania.   Našim cieľom bolo zistiť  ich  názory  na vyučovanie pomocou concept cartoons© a na nami zostavenú metodickú rukoväť k metóde concept cartoons© pre I. stupeň ZŠ.  Prostredníctvom analýzy odpovedí učiteliek sme zistili prevažne pozitívny názor ako na samotnú metódu concept cartoons©, tak aj na zostavenú metodickú príručku k nej.

  12. Anti-cancer activity ofBacillus amyloliquefaciensAK-0 through cyclin D1 proteasomal degradationviaGSK3β-dependent phosphorylation of threonine-286.

    Science.gov (United States)

    Park, Gwang Hun; Song, Hun Min; Kim, Young Soo; Jeon, Yongho; Koo, Jin Suk; Jeong, Hyung Jin; Jeong, Jin Boo

    2017-06-01

    Microorganisms have been regarded as important sources of novel bioactive natural products. In this study, we evaluated the anti-cancer activity and the potential mechanism of Bacillus amyloliquefaciens AK-0 newly isolated from the rhizosphere soil of Korean ginseng. The ethyl acetate fraction from the culture medium of B. amyloliquefaciens AK-0 (EA-AK0) inhibited markedly the proliferation of human colorectal cancer cells such as HCT116, SW480, LoVo and HT-29. EA-AK0 effectively decreased cyclin D1 protein level in human colorectal cancer cells, while cyclin D1 mRNA level was not changed by EA-AK0 treatment. Inhibition of proteasomal degradation by MG132 blocked EA-AK0-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with MRB. In addition, EA-AK0 increased threonine-286 (T286) phosphorylation of cyclin D1, and a point mutation of T286 to alanine attenuated cyclin D1 degradation by EA-AK0. Inhibition of GSK3β by LiCl suppressed cyclin D1 phosphorylation and downregulation by EA-AKO. From these results, EA-AK0 may suppress the proliferation of human colorectal cancer cells by inducing cyclin D1 proteasomal degradation through GSK3β-dependent T286 phosphorylation. These results indicate that EA-AK0 could be used for treating colorectal cancer and serve as a potential candidate for anticancer drug development. In addition, these findings will be helpful for expanding the knowledge on the molecular anti-cancer mechanisms of EA-AK0.

  13. Outcomes from a US military neurology and traumatic brain injury telemedicine program.

    Science.gov (United States)

    Yurkiewicz, Ilana R; Lappan, Charles M; Neely, Edward T; Hesselbrock, Roger R; Girard, Philip D; Alphonso, Aimee L; Tsao, Jack W

    2012-09-18

    This study evaluated usage of the Army Knowledge Online (AKO) Telemedicine Consultation Program for neurology and traumatic brain injury (TBI) cases in remote overseas areas with limited access to subspecialists. We performed a descriptive analysis of quantity of consults, response times, sites where consults originated, military branches that benefitted, anatomic locations of problems, and diagnoses. This was a retrospective analysis that searched electronic databases for neurology consults from October 2006 to December 2010 and TBI consults from March 2008 to December 2010. A total of 508 consults were received for neurology, and 131 consults involved TBI. For the most part, quantity of consults increased over the years. Meanwhile, response times decreased, with a mean response time of 8 hours, 14 minutes for neurology consults and 2 hours, 44 minutes for TBI consults. Most neurology consults originated in Iraq (67.59%) followed by Afghanistan (16.84%), whereas TBI consults mainly originated from Afghanistan (40.87%) followed by Iraq (33.91%). The most common consultant diagnoses were headaches, including migraines (52.1%), for neurology cases and mild TBI/concussion (52.3%) for TBI cases. In the majority of cases, consultants recommended in-theater management. After receipt of consultant's recommendation, 84 known neurology evacuations were facilitated, and 3 known neurology evacuations were prevented. E-mail-based neurology and TBI subspecialty teleconsultation is a viable method for overseas providers in remote locations to receive expert recommendations for a range of neurologic conditions. These recommendations can facilitate medically necessary patient evacuations or prevent evacuations for which on-site care is preferable.

  14. Priča lude babe u smrtopisu obitelji Périer

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    Iva Šarić

    2012-12-01

    Full Text Available Recepcija romana Les Champs d'honneur (1990. Jeana Rouauda redovito se svodi na isticanje dviju njegovih komponenata: autobiografske i povijesne. Naime, u romanu je riječ o osobnoj i obiteljskoj priči, odnosno nedaćama koje su zatekle jednu skromnu obitelj iz francuske provincije 60-ih godina 20. stoljeća, ali i o zbivanjima iz Prvog svjetskog rata koja su toj priči prethodila. Tomu da romaneskni diskurs vuče na autobiografski pridonijela je usporedba, odnosno analogije iz života autora, Jeana Rouauda, s događajima iz romana, ali i brojne autorove paratekstualne napomene u drugim njegovim djelima gdje on te analogije dodatno naglašava i objašnjava. Riječ je, dakle, o samom po sebi kontradiktornom žanru autobiografskog romana s jedne strane te povijesnom romanu s druge, ako se, pak, takvim može nazvati roman čije se tek jedno jedino poglavlje izravno dotiče prave povijesne materije. Rouaud zapravo subverzira autobiografski i historiografski diskurs u romanu, a na trećoj razini tomu treba nadodati i intencionalno poigravanje literarnom tradicijom. Naime, književna kritika naziva Rouauda inherentnim „teoretičarem književnosti” (Lantelme, 122 jer je u cjelokupnom njegovu opusu prisutno promišljanje književnosti preko metadiskursa i kroz uvođenje autora među glavne likove. Autopoetičko seciranje vlastitog rada i njegovo stavljanje u suodnos s književnim prethodnicima nadalje je konstanta Rouaudova djela.

  15. Above-ground net primary productivity in young stands of beech and spruce

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    Pajtík Jozef

    2013-09-01

    Full Text Available V tejto práci sme pomocou kombinácií kontinuálnych meraní a deštruktívnych odberov vzorníkov sledovali a porovnali zásobu nadzemnej biomasy a ročnú primárnu produkciu (NPP v prirodzene obnovených mladých porastoch buka a smreka. Na vybranej lokalite predpokladáme, že zmenené klimatické podmienky budú lepšie vyhovovať buku pred v súčasnosti prevládajúcim smrekom. Lokalita Vrchslatina sa nachádza v južnej časti Veporských vrchov v nadmorskej výške 977 m nad morom (48° 38΄ 50΄΄ N, 19° 36΄ 07΄΄ E. Priemerné ročné zrážky sa pohybujú okolo 900 mm, priemerná ročná teplota je 5,2 °C. Na sledovanej lokalite sme pozorovali odlišný priebeh rastu buka a smreka. Pri buku bola pozorovaná menšia medziročná mortalita, udržiaval sa až prehustený zápoj, v ktorom sa aj podúrovňové stromy snažili dostať do úrovne. Toto sa prejavilo na tvare kmeňov, ktoré sú tenké a vysoké. Štíhlostný koeficient sa pri stromoch so strednou hrúbkou a strednou výškou postupne zvyšoval od 1,19 do 1,40. Pri smreku dochádza k vyššej mortalite, vrastavé a podúrovňové stromy odumierajú z dôvodu nedostatku svetla. Stromy rastú viac do hrúbky, čo sa odráža aj na štíhlostnom koeficiente, ktorý bol po celé obdobie viac-menej konštantný a pohyboval sa v rozpätí 0,89 až 0,93 (tab. 1. Zásoby kmeňa sú pri smreku v jednotlivých rokoch o 3 - 10 m3.ha-1 väčšie ako pri buku (tab. 3. Po prepočítaní na sušinu je vplyvom rozdielnej objemovej hmotnosti (obr. 5 celková zásoba sušiny drevných častí (kmeň a konáre väčšia pri buku (tab. 3. Najväčší rozdiel medzi drevinami je v zásobe asimilačných orgánov, ktorá je pri smreku viac než trojnásobná (tab. 3 a 4. Počas rastu dochádza pri obidvoch drevinách k zvyšovaniu podielu kmeňa a znižovaniu podielu asimilačných orgánov (obr. 2. Hlavný medzidruhový rozdiel pri pomerne vyrovnaných hektárových zásobách je v

  16. Forenzika elektronske pošte

    Directory of Open Access Journals (Sweden)

    Milorad S. Markagić

    2013-10-01

    podataka, pa ih je jednostavnije analizirati i generisati izveštaj. Analiza elektronske pošte zasnovane na internet serverima Za personalnu komunikaciju često  se koriste Web servisi za elektronsku poštu: Google, Yahoo, Hotmail, gmail.... Ovi se servisi koriste bez upotrebe softvera klijenata elektronske pošte i sačinjavaju klijent-server sistem. Web mail sistem predaje elektronsku poruku koristeći SMTP protokol i koristeći POP ili IMAP protokole. Web pošta se ne čuva se na lokalnom računaru, osim ako to korisnik izričito ne zahteva, već ista ostaje memorisana na serveru. Pristup nalogu elektronske pošte na serveru ili prikupljanje podataka o korisničkom nalogu od strane pružaoca usluga umnogome smanjuje količinu posla forenzičkom istražiocu. Ako pristup nije dozvoljen, do web mail poruka može se doći pregledom radne i keš memorije. Kada korisnik proverava poruke, ili sastavlja novu, operativni sistem sačuva podatke sa ekrana na hard disku, pogotovo ako korisniku treba više  vreme da sastavi poruku. Privremeni dokumenti Operativni sistemi privremene dokumente kreiraju za aplikacije koje šalju i primaju podatke preko mreže. Ti se podaci prvo skladište u radnoj memoriji, a kada se ista popuni, operativni sistem pomera podatke niže na listu prioriteta podataka koji su potrebni aplikacijama i zapisuje ih na tvrdi disk. Ne postoji posebno i jedinstveno područje gde se čuvaju privremeni dokumenti jer neke aplikacije stvaraju dodatne privremene datoteke uz one što ih stvara operativni sistem. Aplikacije koje nemaju mogućnost privremenog čuvanja podataka, prepuštaju operativnom sistemu da ih memoriše koristeći swap datoteke ili virtualnu memoriju. Kada aplikaciji zatreba privremeno sačuvani podatak, operativni sistem ga šalje aplikaciji i briše sa hard diska. Iako se swap datoteke brišu, do podataka je ipak moguće doći, jer još uvek fizički postoje na disku Instant poruke U većim organizacijama komunikacija sa korisnicima se

  17. Čekanje

    Directory of Open Access Journals (Sweden)

    Lana Filipin

    2017-06-01

    Full Text Available To je jedan od razloga zašto ne voli kupovati u ovo doba godine – previše ljudi. Ruke su joj pune i kad se sjeti kako je bilo teško odabrati, pomisli: tiranija izbora. Ne točno tim riječima, naravno, jer ovih joj je dana teško pronaći potrebne riječi. Sve dolazi iz nutrine. Osjeća što misli iako to ne može artikulirati. Da je barem hobotnica! Dobro bi mi došao još koji par ruku, pomisli, boreći se da jednom zadrži golem trkaći auto dok drugom podiže plastičnu vrećicu s transformerom koja joj je nekako iskliznula iz ruku. Nespretna. To bi Gunter promrmljao. Nespretna si, Oge. Nespretna. Cokćući jezikom i odmahujući glavom poput oca koji kori dijete. Mrzi kad tako razgovara s njom. Kao da mu je dijete, a ne žena. Kad to radi, nju počne žariti u grlu pa kaže neke stvari pa on kaže neke stvari pa oboje utihnu. No žarenje u grlu još dugo ne posustaje. Boli kao da joj netko trlja sol u ranu. Čir na grlu. Zadivljena je čudom riječi koja je iskrsnula. Niotkud. No takva je narav čuda, zar ne? Dođu niotkud, stvore se pred tobom jer vjeruješ. A ona vjeruje. Zaista, kažem vam, ako imate vjere koliko je zrno gorušičino te reknete ovoj gori: ‘Premjesti se odavde onamo!', premjestit će se. Ustat će i potrčati! Koliko je puta to pastor rekao? Stalno joj je iznova držao propovijed. Vjera je slobodna, rekao je. Samo je moraš prihvatiti! I jest. Prihvatila je. O, itekako jest.

  18. Dosezanje izvan male znanstvene zajednice: modeli društvenog utjecaja na suradnju preko nacionalnih i disciplinarnih granica kod znanstvenika iz triju polja društvenih znanosti

    Directory of Open Access Journals (Sweden)

    Srebrenka Letina

    2016-12-01

    Full Text Available Suradnja sa znanstvenicima iz drugih područja znanosti ili drugih zemalja važna je općenito za napredak znanosti, osobito za znanstvenike koji djeluju u malim i perifernim znanstvenim zajednicama. Cilj je ovog istraživanja bio ispitati postoje li mrežni (strukturni efekti na vjerojatnost da će pojedini znanstvenik ostvariti koautorstvo/suradnju izvan svoje nacionalne i disciplinarne zajednice. Na temelju podataka o koautorstvu na publikacijama indeksiranim u dvjema međunarodnim bazama (Web of Science i Scopus i jednoj nacionalnoj bazi (Nacionalna i sveučilišna knjižnica konstruirana je mreža koautorstva za tri područja društvenih znanosti u Hrvatskoj. Testirana su tri strukturna prediktora (aktivnost, zaraza i popularnost /Ego-2Star/, a korištenje autologističkih modela atributa aktera omogućilo je istovremeno kontroliranje šest atributa aktera. Rezultati su potvrdili hipotezu o postojanju pozitivnog učinka zaraze (vjerojatnost suradnje sa znanstvenicima izvan nacionalne i disciplinarne mreže veća je ako neposredni alter u mreži također ima vanjske suradnje i negativnog učinka aktivnosti (oni koji surađuju s jednim ili više znanstvenika izvan svoje mreže, manje surađuju unutar svoje mreže u mreži obrazovnih znanosti. Međutim, u mreži sociologa utvrđen je samo efekt negativne aktivnosti, dok u mreži psihologa nijedan strukturni efekt nije bio značajan prediktor suradnje izvan uže zajednice. Pronađen je značajan efekt broja radova napisanih u koautorstvu, ali ne i broja jednoautorskih radova, te dobi u svim trima poljima. Spol, lokacija i maksimalna snaga veze imali su različitu ulogu u trima istraživanim poljima. U radu su naglašeni metodološki aspekti analize mreža koautorstva i predlažu smjernice za buduća istraživanja.

  19. Perceptions of Patient Engagement Applications During Pregnancy: A Qualitative Assessment of the Patient's Perspective.

    Science.gov (United States)

    Goetz, Maren; Müller, Mitho; Matthies, Lina Maria; Hansen, Jenny; Doster, Anne; Szabo, Akos; Pauluschke-Fröhlich, Jan; Abele, Harald; Sohn, Christof; Wallwiener, Markus; Wallwiener, Stephanie

    2017-05-26

    highly frequented source of information. Expectations and usability requirements for those applications are also high, thus posing a challenge to interdisciplinary service providers. Patients' attitude toward integrating apps in routine care settings was positive with a favorable influence on patient empowerment. Health care professionals should guide pregnant women toward a successful integration of these educational tools in pregnancy care. ©Maren Goetz, Mitho Müller, Lina Maria Matthies, Jenny Hansen, Anne Doster, Akos Szabo, Jan Pauluschke-Fröhlich, Harald Abele, Christof Sohn, Markus Wallwiener, Stephanie Wallwiener. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 26.05.2017.

  20. Usvojen prijedlog povećanja iznosa općeg (globalnog ograničenja odgovornosti za pomorske tražbine

    Directory of Open Access Journals (Sweden)

    Marija Pospišil Miler

    2012-12-01

    Full Text Available Izmjene Protokola iz 1996. godine (LLMC 1996 Međunarodne konvencije o ograničenju odgovornosti za pomorske tražbine iz 1976. godine (LLMC 1976 usvojene su 19. travnja 2012. na 99. zasjedanju Pravnog odbora IMO-a održanom u Londonu. Tim izmjenama iznos općeg (globalnog ograničenja odgovornosti za pomorske tražbine povećan je za 51% u odnosu na iznose iz čl. 3. LLMC 1996 koji se odnose na čl. 6.1(a i 6.1(b, LLMC 1976, dok iznosi iz čl. 7. Konvencije nisu mijenjani. Povećani iznosi primjenjivat će se od 8. lipnja 2015. godine. U radu se analiziraju razlozi koji su doveli do povećanja iznosa općeg (globalnog ograničenja odgovornosti kao i opravdanost ovog povećanja iznosa ograničenja odgovornosti ako se uzme u obzir da je samo u 1,34% slučajeva šteta prelazila sadašnji iznos ograničenja odgovornosti utvrđen u LLMC 1996. Analiziraju se pravne i ekonomske posljedice ovog povećanja iznosa općeg ograničenja odgovornosti te njegov neposredan utjecaj na druge međunarodne konvencije vezane na iznose općeg ograničenja odgovornosti kao što su Bunker konvencija iz 2001. i Međunarodna konvencija o uklanjanju podrtina iz 2007. godine. Upozorava se, međutim, da tendencija koja vodi prema previsokim iznosima ograničenja odgovornosti može izazvati smanjenje interesa država za ratifikacijom LLMC 1996 što će se negativno odraziti na unifikaciju prava u odnosu na ovo pitanje. U radu se stoga razmatraju rješenja koja bi omogućila pravednu naknadu oštećenima i ostvarenje svrhe instituta ograničenja odgovornosti, a ne bi ugrozila unifikacijska nastojanja.

  1. Podrumko

    Directory of Open Access Journals (Sweden)

    Manfred Kyber

    2016-12-01

    Full Text Available Između ponoći i jednog sata oživi sve ono za što glupi ljudi vjeruju da oživjeti ne može. Ali zaista, mnogobrojne stvari koje inače samo ukočeno i mirno leže, kao da ne mogu reći ni „dobar dan“, sve one u to vrijeme ožive. I ne brinu mnogo o tome vjeruju li glupi ljudi u to ili ne. Tako i u tom starom gradiću oživje sve kada sat sa zvonika crkve Presvete Djevice Marije s dvanaest muklih, teških udaraca otkuca ponoć. Kamenje na pločniku počelo je razgovarati s vlatima trave koja je među njim rasla i pitalo je koliko još misli ostati. Zabati i erkeri kuća u uskim zamršenim uličicama kimali su jedni drugima, a ulične svjetiljke žalile su se na vjetar; prehladile su se jer on tako bezobzirno mijenja smjer.Također oživje sve i u starom vinskom podrumu staroga gradića. Mnogobrojne bačve koje stajahu jedne pokraj drugih, velike i male, zijevnuše i protegnuše se i ispružiše se, a kad bi jedna drugu pritom gurnula, rekla bi: „Oh, tisuću puta oprostite!“ Jer bačve su vrlo pristojne i znaju se lijepo ponašati. Tada bi sve uspravno stale na svoje debele nožice – naime, bačve imaju nožice, ako glupi ljudi ne znaju ni to – i sve bi se klanjale jedne drugima i kimale si i pozdravljale se na sve stane.

  2. Decision support systems in Slovak forestry planning: a review / Systémy na podporu rozhodovania v lesníckom plánovaní na Slovensku: prehľad

    Directory of Open Access Journals (Sweden)

    Tuček Ján

    2015-03-01

    Full Text Available Projekt Akcie COST FP 0804 - FORSYS zhŕňa európske skúsenosti v oblasti rozvoja a využívania systémov pre podporu rozhodovania v obhospodarovaní lesov. Predložený príspevok sa zaoberá metodikou FORSYS pre klasifikáciu súčasných problémov lesného hospodárstva a pre opis existujúcich systémov pre podporu rozhodovania. Identifikuje základné problémy lesníckeho plánovania, ktoré je potrebné riešiť na Slovensku, uvádza DSS nástroje ktoré sú k dispozícii a hodnotí ich schopnosť riešiť identifikované problémy. Na záver sú identifikované potreby výskumného riešenia a existujúce nedostatky v tejto oblasti. Na odôvodnenie zistených potrieb sa tiež uvádza porovnanie situácie v oblasti podpory rozhodovania na Slovensku so situáciou v Európe a susedných krajinách (Rakúsko, Maďarsko. Článok je zameraný na prehľad modelov a metód rozhodovania ako aj techník na manažment znalostí, ktoré sú aktuálne na Slovensku k dispozícii. Všeobecne možno konštatovať, že výskum v oblasti podpory rozhodovania na Slovensku síce sleduje stav v Európe, avšak so značným časovým oneskorením a výrazným nedostatkom vhodných nástrojov pre riešenie aktuálnych plánovacích problémov. V dôsledku toho existuje silná potreba pre vývoj a aplikácie počítačových nástrojov na podporu rozhodovania problémov hospodárenia v lesoch.

  3. Distribution, abundance, breeding parameters, threats and prey preferences of the eastern imperial eagle (Aquila heliaca in European Turkey

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    Demerdzhiev Dimitar

    2014-01-01

    Full Text Available V období 2008-201 3 bolo orlami královskými obsadených 32 rôznych hniezdnych teritórií. Tieto územia sa nachádzajú najmä v dvoch oblastiach: pohorie Derventa/Yıldız a územie na sever od Marmarského mora. Najbližšia vzdialenost medzi hniezdiskami bola 4,2 km. Stredná vzdialenost medzi pármi bola 1 0,44 ± 2,95 km. Priemerná hodnota hniezdnej úspešnosti v období 2008-201 3 vrátane 1 07 prípadov inkubácii bola 1 ,01±0,1 0. Priemerná hniezdna úspešnost vtákov v Marmarskom regióne (1 ,05±0,78 bola vyššia ako v oblasti pohorí Derventa/Yıldız (0,91±0,84. Predkladaná štúdia potravy orla královského bola založená na 582 zvyškoch koristi, obsahujúcej minimálne 70 taxónov. Cicavce boli najrozšírenejšie skupinou (46.5 %, nasledované vtákmi (32,4 % a plazmi (20,3 %. Najcastejšou koristou bol jež bledý (Erinaceus roumanicus a dva druhy korytnaciek - korytnacka zelenkastá (Eurotestudo hermanni a korytnacka grécka (Testudo graeca, ktoré dohromady predstavovali celkom 1 4,4 % z ulovenej koristi. Potravné spektrum sledovaných párov obsahoval tieto druhy koristi: cajka žltonohá (Larus michahellis, sysel pasienkový (Spermophilus citellus, domáca sliepka (Gallus gallus f. domestica a bocian biely (Ciconia ciconia. Tieto druhy dohromady tvorili 67,8 % z ulovenej koristi. Bol preukázaný štatisticky významný rozdiel (Z=2,52, p=0,01 v preferencii potravy orlov královských v oboch študovaných oblastiach.

  4. Acute ghrelin changes food preference from a high-fat diet to chow during binge-like eating in rodents.

    Science.gov (United States)

    Bake, T; Hellgren, K T; Dickson, S L

    2017-04-01

    Ghrelin, an orexigenic hormone released from the empty stomach, provides a gut-brain signal that promotes many appetitive behaviours, including anticipatory and goal-directed behaviours for palatable treats high in sugar and/or fat. In the present study, we aimed to determine whether ghrelin is able to influence and/or may even have a role in binge-like eating behaviour in rodents. Accordingly, we used a palatable scheduled feeding (PSF) paradigm in which ad lib. chow-fed rodents are trained to 'binge' on a high-fat diet (HFD) offered each day for a limited period of 2 hours. After 2 weeks of habituation to this paradigm, on the test day and immediately prior to the 2-hour PSF, rats were administered ghrelin or vehicle solution by the i.c.v. route. Remarkably and unexpectedly, during the palatable scheduled feed, when rats normally only binge on the HFD, those injected with i.c.v. ghrelin started to eat more chow and chow intake remained above baseline for the rest of the 24-hour day. We identify the ventral tegmental area (VTA) (a key brain area involved in food reward) as a substrate involved because these effects could be reproduced, in part, by intra-VTA delivery of ghrelin. Fasting, which increases endogenous ghrelin, immediately prior to a palatable schedule feed also increased chow intake during/after the schedule feed but, in contrast to ghrelin injection, did not reduce HFD intake. Chronic continuous central ghrelin infusion over several weeks enhanced binge-like behaviour in palatable schedule fed rats. Over a 4-week period, GHS-R1A-KO mice were able to adapt and maintain large meals of HFD in a manner similar to wild-type mice, suggesting that ghrelin signalling may not have a critical role in the acquisition or maintenance in this kind of feeding behaviour. In conclusion, ghrelin appears to act as a modulating factor for binge-like eating behaviour by shifting food preference towards a more nutritious choice (from HFD to chow), with these effects

  5. Učim majku kako da rodi

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    Warsan Shire

    2015-12-01

    Full Text Available EstagfirullahInna Lillahi wa inna ilayhi raji'unda će plutati. Pa, mislim da me dom ispljunuo, nestanci struje i policijski sat kao jezik uz klimavi zub. Bože, znaš li kako je teško pričati o danu kada te vlastiti grad vukao za kosu, kraj starog zatvora, kraj školskih vrata, kraj gorućih torza nabijenih na stupove kao zastave? Kada upoznam druge nalik sebi, prepoznajem čežnju, nedostajanje, sjećanje na pepeo na njihovim licima. Nitko ne napušta dom osim ako dom nisu usta morskog psa. Nosila sam tu staru himnu u ustima tako dugo da više nije bilo mjesta ni za jednu drugu pjesmu, drugi jezik i drugi govor. Poznajem strah koji te prekriva, u potpunosti guta. Rastrgala sam i pojela svoju putovnicu u hotelu zračne luke. Naduta sam jezikom koji si ne mogu priuštiti da zaboravim.*Znam da je nekoliko stvari istinito. Ne znam kamo idem, a odakle dolazim nestaje, nisam dobrodošla i moja ljepota ovdje nije ljepota. Moje tijelo gori sramom nepripadanja, moje tijelo žudi. Ja sam grijeh sjećanja i odsustvo sjećanja. Gledam vijesti i usta mi postaju umivaonik pun krvi. Redovi, formulari, ljudi za stolovima, posjetnice, imigracijski službenik, pogledi na ulici, hladnoća koja se nastanjuje duboko u moje kosti, satovi engleskog u večernjim satima, udaljenost koja me dijeli od doma. Ali, elhamdulillah, sve je ovo bolje od mirisa žene u plamenu, ili kamiona punog muškaraca koji izgledaju kao moj otac, koji mi čupaju zube i nokte, ili četrnaest muškaraca između mojih nogu, ili pištolj, ili obećanje, ili laž, ili njegovo ime, ili njegova muškost u mojim ustima.

  6. Total flotation and backfill

    Directory of Open Access Journals (Sweden)

    Carlos Villachica León

    2001-03-01

    Full Text Available Kolektívna flotácia a zavážanie (TFB boli navrhnuté ako ve¾mi výhodný technologický postup pre dosiahnutie trvalého rozvoja pri podzemnej ažbe polymetalických rúd v Peru. Táto technológia zlepšuje ekonomiku, znaène znižuje väèšinu environmentálnych problémov, ktoré súvisia s prevádzkovaním jemných odpadov, kyslými vodami a nadmerným používaním chemikálií v úpravniach.Kolektívna flotácia (TF je založená na mimoriadne hrubom mletí a flotácii sulfidov neželezných kovov s výnimkou pyritu. Získaný produkt je kolektívny koncentrát s hmotnosou 15-25 % hmotnosti vyaženej rudy. Postup umožòuje ve¾mi jednoduchú schému aplikácie flotaèného režimu a flotaèného okruhu bez stupòov triedenia, zahusovania a filtrácie. Úpravne pracujúce v TF režime sú tak malé, že ich je možné inštalova v podzemí, èím sa znaène znížia náklady a infraštruktúra potrebné pre manipuláciu s rudou a jej dopravou na povrch.Odpady z TF prevádzkovanej v podzemí sú hrubozrné takže je možné ich zavážanie bez predchádzajúceho triedenia za úèelom odstránenia jemných podielov. Tým sa znižuje množstvo odpadu, ktoré sa má èerpa na povrch až na 5-10 % hmotnosti vyaženej rudy. Kolektívny koncentrát sa èerpá na povrch, kde sa premie¾a a separuje na koncentráty Cu, Pb a Zn a pyritový koncentrát. V prípade Peru táto separaèná jednotka (SP môže by vzdialená od miesta ažby.V prípade novej baníckej technológie TFB dochádza k dramatickým zmenám pri návrhu a projektovaní banského diela. Technológiu TFB je možné tiež úspešne aplikova v jestvujúcich baniach, kde je nutné aži hlboko uložené ložiská. V tejto práci sa popisujú skúšky s TFB technológiou pre Zn-Pb ložisko ve¾kej håbky. V týchto skúškach sa dosiahli výažnosti pre Zn a Pb do 90 % pre koncentrát tvoriaci 15 % vyaženej rudy pri hrubom mletí (25 % - 200 mesh pri

  7. Modelling the Uncertainty of Slope Estimation from a Lidar-Derived Dem: a Case Study from a Large-Scale Area in the Czech Republic / Modelovanie Neistoty Vo Výpočte Sklonov Z Lidarových Dmr; Prípadová Štúdia Vybraného Malého Územia V Čr

    Directory of Open Access Journals (Sweden)

    Mudron Ivan

    2013-06-01

    Full Text Available Táto práca zhŕňa metódu a výsledky modelovania chýb a analýzu šírenia chýb vo výpočte sklonov z DMR získaných LIDAR-om v skúmanej lokalite okolia sútoku riek Olše a Stonávka. V terénnych analýzach výstupy uvedenej analýzy sú vždy funkciou vstupu. Na generovania pola výškových chýb boli použité dve rozdielne metódy podľa vstupných dát. Modelované chyby v nadmorských výškach následne vstupovali do analýzy šírenia chýb. Hlavným cieľom práce bolo tak ako aj poukázanie na význam kvality vstupných dát vo výpočte sklonov a odhad šírenej chyby z nadmorských výšok v sklonoch tak aj identifikácia chýb v DMR a ich dopad. Závislosti chýb boli vyhodnotené hlavne pre lepší odhad chyby v sklonoch. V simuláciách boli použité 4 vstupné DMR s rozlíšením 0.5, 1, 5 a 10 metrov s RMSE chybou do 0.317 metra (10 m DMR. Všetky DMR boli získané z mračna bodov získaných LIDAR metódou zberu dát. Šírenie chýb bolo modelované pomocou stochastickej simulácie Monte Carlo s 250 iteráciami. Článok sa zameriava na šírenie chýb z vysoko presných vstupných dát na malom území. RMSE chyba bola získaná v prvom prípade z dát získaných terénnym prieskumom (RTK GPS a v druhom prípade z porovnania dvoch kvalitatívne rozdielnych DMR. V prvom prípade sa vypočítali chyby vo výškach pomocou náhodného generátora chýb bez autokorelácie chýb. V druhom prípade sa s pomocou semivariogramu namodelovalo autokorelované pole chýb vo výškach. Použitím vhodných štatistík boli odvodené výsledky simulácie a overené stanovené hypotézy. Tak ako sa očakávalo chyby v sklonoch sú vyššie s zvyšujúcou sa chybou v nadmorských výškach. Tiež závislosti chýb od vypočítaných sklonov boli preskúmané, kde sa potvrdila závislosť chýb na sklonoch. Na druhej strane geológia nemala žiaden vplyv na chybu v sklonoch. Chyby namodelované bez autokorelácie nevedú vo v

  8. Utjecaj stupnja uglazbljenosti teksta na upamćivanje teksta

    Directory of Open Access Journals (Sweden)

    Augustin Mutak

    2017-07-01

    Full Text Available Introspektivni nalazi pokazuju kako ljudi lakše i dulje pamte uglazbljeni materijal od drugih vrsta materijala. Sukladno tome, pokazuje se i da ljudi vjeruju da je glazba dobar mnemonik te da pomaže upamćivanju. Međutim, eksperimentalne provjere ne potvrđuju ove teze. U eksperimentima se pokazuje kako je pozitivan utjecaj glazbe na upamćivanje ovisan o uvjetima upamćivanja (npr. uglazbljen i neuglazbljen tekst pamte se jednako dobro ako je brzina prezentiranja riječi ista. Utjecaj stupnja uglazbljenosti materijala na njegovo upamćivanje vrlo se rijetko istražuje i stoga predstavlja predmet ovog istraživanja. Također, ovim je istraživanjem ispitano mijenjaju li se strategije upamćivanja materijala ovisno o stupnju njegove uglazbljenosti te mijenjaju li se karakteristike materijala na kojima se upamćivanje temelji ovisno o stupnju uglazbljenosti samog materijala.U istraživanju je sudjelovao 91 sudionik. Sudionici su podijeljeni u tri skupine, a zadatak je svake skupine bio pokušati u što većoj mjeri upamtiti tekst skladbe. Pritom je prva skupina slušala a capella izvedbu, druga skupina vokalnu izvedbu praćenu bubnjevima, a treća potpuno uglazbljenu vokalnu izvedbu. Sudionici su slušali skladbu šest puta i nakon svakog slušanja zapisivali stihove koje su upamtili. Također, sudionici su ispunili i Upitnik o korištenim strategijama.Analizom varijance nisu utvrđene razlike u broju upamćenih stihova između tri skupine sudionika koje su slušale materijal različitog stupnja uglazbljenosti. Također, nisu utvrđene razlike u čestini korištenja različitih strategija upamćivanja. Međutim, Fisherovim je egzaktnim testom utvrđen trend koji pokazuje da povećanjem stupnja uglazbljenosti teksta raste i broj sudionika koji izjavljuju da im pri upamćivanju pomaže glazba. Također, s povećanjem stupnja uglazbljenosti materijala smanjuje se broj osoba koje izjavljuju da im pri upamćivanju teksta pomaže priroda vokala

  9. NASA's Chandra Reveals Origin of Key Cosmic Explosions

    Science.gov (United States)

    2010-02-01

    WASHINGTON -- New findings from NASA's Chandra X-ray Observatory have provided a major advance in understanding a type of supernova critical for studying the dark energy that astronomers think pervades the universe. The results show mergers of two dense stellar remnants are the likely cause of many of the supernovae that have been used to measure the accelerated expansion of the universe. These supernovae, called Type Ia, serve as cosmic mile markers to measure expansion of the universe because they can be seen at large distances, and they follow a reliable pattern of brightness. However, until now, scientists have been unsure what actually causes the explosions. "These are such critical objects in understanding the universe," said Marat Gilfanov of the Max Planck Institute for Astrophysics in Germany and lead author of the study that appears in the Feb. 18 edition of the journal Nature. "It was a major embarrassment that we did not know how they worked. Now we are beginning to understand what lights the fuse of these explosions." Most scientists agree a Type Ia supernova occurs when a white dwarf star -- a collapsed remnant of an elderly star -- exceeds its weight limit, becomes unstable and explodes. Scientists have identified two main possibilities for pushing the white dwarf over the edge: two white dwarfs merging or accretion, a process in which the white dwarf pulls material from a sun-like companion star until it exceeds its weight limit. "Our results suggest the supernovae in the galaxies we studied almost all come from two white dwarfs merging," said co-author Akos Bogdan, also of Max Planck. "This is probably not what many astronomers would expect." The difference between these two scenarios may have implications for how these supernovae can be used as "standard candles" -- objects of a known brightness -- to track vast cosmic distances. Because white dwarfs can come in a range of masses, the merger of two could result in explosions that vary somewhat in

  10. Molecular analysis of markers associated with chloroquine and sulfadoxine/pyrimethamine resistance in Plasmodium falciparum malaria parasites from southeastern Côte-d'Ivoire by the time of Artemisinin-based Combination Therapy adoption in 2005

    Directory of Open Access Journals (Sweden)

    Ako BA

    2012-08-01

    Full Text Available Berenger Aristide Ako,1 André Toure Offianan,1 Marnie Johansson,2 Louis Koné Penali,1 Simon-Pierre Assanvo Nguetta,3 Carol Hopkin Sibley21Department of Malariology, Institut Pasteur de Côte-d'Ivoire, Abidjan, Côte d'Ivoire; 2Department of Genome Sciences, University of Washington, Seattle, WA, USA; 3Laboratoire de Génétique, Université de Cocody, Abidjan, Côte d'IvoirePurpose: Artemisin-based combination therapies became the recommended therapy in Côte-d'Ivoire in 2005, but both chloroquine (CQ and sulfadoxine/pyrimethamine (SP have been heavily used for many decades. Despite this long history, little is known about the geographical distribution of drug resistance–conferring genotypes outside the capital city of Abidjan. In this work, we compared the prevalence of drug-resistant genotypes in Bonoua, an urban area, and Samo, a rural agricultural area, in southeastern Côte-d'Ivoire, about 59 km from Abidjan.Patients and methods: Samples were collected from symptomatic patients in both sites during the rainy season in 2005. Genomic DNA was isolated and codons associated with resistance to CQ and SP were analyzed: pfcrt codons Cys-72-Ser, Val-73-Val, Met-74-Ile, Arg-75-Glu, Lys-76-Thr; pfdhfr codons Ala-16-Val, Arg-51-Ile, Cys-59-Arg, Ser-108-Arg/Thr, and Ile-164-Leu; pfdhps codons Ser-436-Ala, Ala-437-Gly, Lys-540-Glu, Ala-581-Gly, and Ala-613-Thr/Ser.Results: A limited number of genotypes were found in Bonoua compared with Samo. In both sites, the triple-mutant allele CVIET of pfcrt predominated: 100% in Bonoua and 86.2% in Samo. The wild-type allele, NCSI of pfdhfr, was common – 50% in Bonoua and 38.7% in Samo – but the triple-mutant IRNI and double-mutant NRNI were also frequent (IRNI, 32.6% in Bonoua and 19.4% in Samo; NRNI, 15.2% in Bonoua and 9.7% in Samo. In Samo, a wide range of different genotypes of Pfdhps was observed, with alleles carrying the Gly-437 codon fixed in Bonoua and comprising 73% of the isolates in Samo

  11. Psychologist in a Pocket: Lexicon Development and Content Validation of a Mobile-Based App for Depression Screening.

    Science.gov (United States)

    Cheng, Paula Glenda Ferrer; Ramos, Roann Munoz; Bitsch, Jó Ágila; Jonas, Stephan Michael; Ix, Tim; See, Portia Lynn Quetulio; Wehrle, Klaus

    2016-07-20

    PiaP, we were able to gather 1762 main keywords and 9655 derivatives of main keywords. In addition, we compiled 823,869 spelling variations. Keywords included negatively-valenced words like "sad", "unworthy", or "tired" which are almost always accompanied by personal pronouns, such as "I", "I'm" or "my" and in Filipino, "ako" or "ko". For the content validation, only keywords with CVR equal to or more than 0.75 were included in the depression lexicon test-run version. The mean of all CVRs yielded a high overall CVI of 0.90. A total of 1498 main keywords, 8911 derivatives of main keywords, and 783,140 spelling variations, with a total of 793, 553 keywords now comprise the test-run version. The generation of the depression lexicon is relatively exhaustive. The breadth of keywords used in text analysis incorporates the characteristic expressions of depression and its related constructs by a particular culture and age group. A content-validated mobile health app, PiaP may help augment a more effective and early detection of depressive symptoms.

  12. O definiciji zamenica

    Directory of Open Access Journals (Sweden)

    Ivan Klajn

    1975-11-01

    Full Text Available Četiri osnovna kriterija za definiciju vrsta reči jesu sintaktička funkcija, oblik, distribucija i značenje. Ovaj poslednji je najneodređeniji (poznata je neadekvatnost školskih definicija kao »imenice označavaju osobe i stvari«, »glagoli označavaju radnje« i sl., ali postaje pouzdaniji ako ga zasnujemo na razlici između »punih« (leksičkih i »praznih« (gramatičkih reči, i leksema i morfema u Martinetovom smislu. Zamenice u ovom pogledu zadaju još veće teškoće nego ostale vrste reči. Klasična definicija po kojoj su to »reči koje zamenjuju imenice« primenljiva je u stvari samo na manji deo njih. U rečenici » Ja radim«, ja ne zamenjuje imenicu (jer se imenica ne bi ni mogla upotrebiti u tom kontekstu, nego samo ima sintaktičku funkciju imenice (subjekat. Slično torne, pridevske zamenice kao moj, taj, neki imaju sintaktičku funkciju prideva (određuju imenicu. Otuda se predlaže sledeća definicija: zamenice su reči koje imaju sintaktičku funkciju imenice ili prideva, ali se od ovih razlikuju po obliku, značenju i/ili distribuciji. Nasuprot ovoj empirijskoj definiciji mogao bi se postaviti zahtev za »Čistom « definicijom, koja bi otkrila neku inherentnu osobinu zamenica. Pada u oči da su zamenice same po sebi »prazne« reči, ali da se u upotrebi mnoge od njih »ispunjavaju« konkretnim leksičkim značenjem (npr. »On« = Marko, »njegov « = Markov, »obratih se Marku, a ovaj reče« = a Marko reče, itd.. Na žalost, za druge zamenice (upitne, neodređene, pokazne neanaforične ta osobina ne važi. Zajedničko obeležje svih zamenica pre bi se moglo tražiti u deiksi, tj. u sposobnosti pokazivanja ili ukazivanja. Pri tom bismo pod tim terminom morali podrazumevati dve srodne pojave: spoljna deiksa je ukazivanje na predmete i bića iz materijalnog sveta( »ja«, »ti«, »moj«, »dodajte mi to« ili na pojmove (»Ono su bila lepa vremena«, »0 tome neću da razgovaram«. Unutrašnja deiksa je ukazivanje

  13. Neki problemi pri prevođenju moderne poezije promatrani kroz teoriju konceptualne integracije

    Directory of Open Access Journals (Sweden)

    Sanja Cimer

    2011-12-01

    koji slijede u vlastitom su prijevodu, osim ako nije drugačije naznačeno. U 20. stoljeću oformio se, između ostalih, pristup da je zadatak prevoditelja prijevodom oponašati izvorno lirsko djelo, a uz to što prijevod treba preslikavati original, on također treba zadržati i njegovu poetsku vrijednost te u ciljnom jeziku funkcionirati kao samostalna poetska forma (bez glosa, komentara ili fusnota. Budući da je svaka pjesma priča za sebe, svaki je prevoditelj pri definiranju prioriteta (zvučnost? semantika? rima? ritam? prepušten samom sebi i konstantno se suočava s izborima (Jones (citat u Connolly 174 prevođenje poezije naziva “umjetnošću kompromisa”. W. S. Merwin opisuje svoj pristup prevođenju poezije na sljedeći način: “Znate, i dalje vjerujem da ne znam kako se prevodi i da to nitko ne zna. To je nemoguć, ali nužan proces, ne postoji savršen način da se on izvede i velik njegov dio mora se oblikovati u hodu za svaku pojedinačnu pjesmu.”

  14. Commercial-Scale Demonstration of the Liquid Phase Methanol (LPMEOH) Process

    Energy Technology Data Exchange (ETDEWEB)

    None

    1998-12-21

    The Liquid Phase Methanol (LPMEOW) Demonstration Project at Kingsport Tennessee, is a $213.7 million cooperative agreement between the U.S. Department of Energy (DOE) and Air Products Liquid Phase Conversion Company, L.P. (the Partnership) to produce methanol from coal-derived synthesis gas (syngas). Air Products and Chemicals, Inc. (Air Products) and Eastman Chemical Company (Eastman) formed the Partnership to execute the Demonstration Project. The LPMEOW Process Demonstration Unit was built at a site located at the Eastman complex in Kingsport. During this quarter, initial planning and procurement work began on the seven project sites which have been accepted for participation in the off-site, methanol product-use test plan. Two of the projects have begun pre-testing of equipment and three other projects have commenced with equipment procurement, Methanol produced from carbon monoxide (CO)- rich syngas at the Alternative Fuels Development Unit (AFDU) in LaPorte, TX has been shipped to four of the project sites in anticipation of the start of testing during the first quarter of calendar year 1998. Catalyst activity, as defined by the ratio of the rate constant at any point in time to the rate constant for a freshly reduced catalyst (as determined in the laboratory autoclave), continued to decline more rapidly than expected. In response to concentrations of arsenic and sulfbr detected on catalyst samples from the LPMEOW Reactor, Eastman replaced both the arsine- and sulfiwremoval material in the Eastman guard bed which treats the primary syngas feed stream (&danced Gas) prior to its introduction into both the Eastman fixed-bed methanol plant and the LPMEOWM Demonstration Unit. After restarting the demonstration unit, the catalyst deactivation rate remained essentially unchanged. Parallel testing in the laboratory using arsine-doped, and subsequently arsine- and SuIfi-doped syngas, ako ftiIed to prove that arsine was responsible for the higher-than-expected rate of

  15. Romanian Association of Balneology Conference – 2015, 28 – 31 May, Băile Tuşnad

    Directory of Open Access Journals (Sweden)

    MUNTEANU Constantin

    2015-05-01

    Full Text Available 1.\tProf. Onose G, MD, PhD, MSc, Univ. Assist. Haras MA, MD, PhD, Prof. Sinescu CJ, MD, PhD1,2, Univ. Assist. Daia CO, MD, PhD1,2, RDI Assist. Andone I, MD, Postgrad2, Onose VL, MD,3, Assist. Prof. Capisizu A, MD, PhD1,4, Prof. Grigorean VT, MD, PhD1,2, Assoc. Prof. Ciobotaru C, MD, PhD5,6, Sandu AM, MD, Postgrad.2, Assist. Prof. Blendea CD, MD, PhD7, 8 - BASIC WELLNESS FEATURES AND SOME RELATED ACTIONS, PROPENSIVE INCLUDING FOR ACTIVE AND HEALTHY AGEING - 2.\tOlga SURDU, T.V. SURDU, Monica SURDU - STATE OF ART of balneotherapy/thermalisme in Romania 3.\tIliuta Maria Alexandra - THE IMPORTANCE OF NUTRITION IN HEALTH PROGRAMS 4.\tDr. Dogaru Gabriela - THERAPEUTIC EFFECTS OF MINERAL WATERS IN RENAL DISEASES 5.\tVeryho N.S. - THERAPEUTIC EFFECT OF MINERAL WATER WITH DIFFERENT CONCENTRATIONS OF HUMIC ACIDS IN EXPERIMENTAL HEPATITIS INDUCED BY ACETAMINOPHEN 6.\tIoana Marian - SPA SEEN AS AN EXTENSION OF A HEALTH RESORT - A NECESSARY CONDITION FOR INTEGRATING ROMANIA IN THE LIST OF GLOBAL WELLNESS TOURISM DESTINATIONS 7.\tBilha Neli-Claudia, Bilha Stefan - THE BALNEARY TREATMENT COURSE – A BREATH OF LIFE 8.\tBilha Neli-Claudia, Bilha Stefan - WICH SALT MINE DO YOU RECOMMEND FOR SPELEOTHERAPY? Interdisciplinary project proposal. 9.\tGáspár Boróka, Gabriela Dogaru - BALNEOTHERAPY IN THE BOGHIŞ RESORT 10.\tDr. Luminita Aurelia Pasca - REHABILITATION OF ELDERLY PATIENTS WITH CARDIOVASCULAR DISEASE 11.\tDr. Luminita Aurelia Pasca, Dr. Valer Donca - GEROVITAL – PROPHYLAXIS OF AGING AND GERIATRIC TREATMENT 12.\tAndronache Cristina - IMPORTANCE OF REHABILITATION TREATMENT IN HEMOPHILIC ARTHROPATHY – A CASE REPORT 13.\tDr. Motricala Marieta, Molnar Akos - BALNEOTHERAPY IN BAILE TUSNAD 14.\tIoana Pop, Bianca Pop - MEDICAL REHABILITATION IN NEUROPATHIC PAIN 15.\tAmalia Salca¹, Nicoleta Stoica1, Gabriela Dogaru¹,² - BALNEOTHERAPY IN GONARTHROSIS 16.\tAlexandru Bogdan-Cătălin, Toşa Edith-Éva - USING PULSED SHORT WAVE (DIAPULSE COMPLEMENTARY TO

  16. EFFECT OF DIFFERENT COOLING SYSTEMS ON LYING TIME OF DAIRY COWS IN CUBICLES WITH SEPARATED MANURE SOLIDS BEDDING VPLYV ROZDIELNYCH SYSTÉMOV OCHLADZOVANIA NA DOBU LEŢANIA DOJNÍC USTAJNENÝCH V LEŢISKOVÝCH BOXOCH PODSTIELANÝCH SEPAROVANÝM KALOM HNOJOVICE

    Directory of Open Access Journals (Sweden)

    Jana LENDELOVÁ

    2012-12-01

    sprchový systém s ventilátormi. Aktivity a odpočinok zvierat boli hodnotené v 10 minútových intervaloch pomocou kamerového systému po dobu 24 hodín. K štatistickému vyhodnoteniu získaných údajov bola pouţitá neparametrická Kruskal-Wallisová jednofaktorová analýza rozptylu a mnohonásobný porovnávací test k zisťovaniu preukaznosti rozdielov jednotlivých prejavov správania medzi skupinami dojníc. Zvýšené prúdenie vzduchu ventilátormi malo pozitívny účinok a zosilnilo ochladzovací efekt zvierat vyuţívajúcich evaporačné ochladzovanie sprchovým systémom. Bolo zistené preukazné predĺţenie celkovej doby leţania a skrátenie doby státia. Zvieratá v skupine SV so sprchami a ventilátormi leţali v boxoch dlhšie ako v skupine S so sprchami bez ventilátorov (10.76 h*d-1*ks-1 oproti 7.71 h*d-1*ks-1, P<0.001. Celkové leţanie v skupine SV predstavovalo 11.31 h*d-1*ks-1a v skupine S 10.22 h*d-1*ks-1. Menej ochladzované zvieratá v skupine bez ventilátorov preukazne viac zalíhali do chodby (2.52 h*d-1*ks-1 oproti 0.56 h*d-1*ks-1, P<0.001, a to aj v nočnom období.

  17. Compromising electromagnetic radiation - challenges, threats and protection / Компрометирующее электромагнитное излучение – вызовы, угрозы и защита / Kompromitujuća elektromagnetna zračenja - izazovi, pretnje i zaštita

    Directory of Open Access Journals (Sweden)

    Milorad S. Markagić

    2018-01-01

    онтроль побочных излучений. / Cilj ovog rada jeste da se sagleda problematika parazitskih zračenja, kako induktivnih, tako i konduktivnih, koja emituju uređaji za prenos podataka, uređaji za obradu, generisanje i zaštitu podataka i njihovi sklopovi. Uređaji koji se koriste u svakodnevnoj kućnoj upotrebi i u komunikaciji među pojedincima ili institucijama, osim korisnog elektromagnetnog zračenja sadrže i deo nekorisnog, ali i neizbežnog signala koji je van kontrole proizvođača. Uređaji koji služe za kriptoobradu informacija posebno su osetljivi na ovu pojavu, jer svaki vid zaštite gubi smisao ako se u ma kom delu dođe do dela korisne informacije, a jedan od bitnijih segmenata dolaska do njih podrazumeva i praćenje parazitskih zračenja.

  18. Metod vektora sličnosti idealu za višeatributno odlučivanje / Method of the vector of similarity to ideal solution in alternatives / Метод вектора сходства вариантов с идеальным решением

    Directory of Open Access Journals (Sweden)

    Radomir R. Đukić

    2016-01-01

    Full Text Available U članku se razmatra postupak rešavanja problema višeatributnog odlučivanja na jednom nivou kriterijuma i prezentuje metod zasnovan na elementima kompromisnog odlučivanja, Lp metrici i TOPSIS metodu. Daju se preporuke za formiranje početne matrice odlučivanja i transformaciju raznorodnih kriterijumskih vrednosti. Kompromisna rešenja dobijaju se na osnovu vrednosti funkcija Lp metrike i njihovih kombinacija sa koeficijentima − funkcijama relativne verodostojnosti zavisnim od dimenzija problema. Dobijena rešenja zavisna su od parametra p u Lp metrici koji je balansirajući faktor između rešenja sa najvećom ukupnom koristi i rešenja sa minimaks odstupanjima kriterijumskih vrednosti od ideala i antiideala. Ako se zahteva jedinstveno rešenje, ono se dobija objedinjavanjem svih funkcija Lp metrike i primenom vektora sličnosti varijanata idealu, kojim je obuhvaćen i uticaj antiideala. Prikazan je i postupak dobijanja kompromisnih rešenja na osnovu vrednosti elemenata parcijalnih vektora sličnosti idealu i uticaj subjektivno određenog antiideala na rešenja. Primena metoda prikazana je numeričkim primerom. / A method for solving multiple-attribute decision-making problems at one criterion level is discussed, followed by a presentation of a method based on compromise programming elements, Lp metrics and the TOPSIS method. Suggestions for forming the initial decisionmaking matrix have been given as well as for the transformation of multiple criteria values. Compromise solutions are obtained based on the values of Lp metrics functions and their combinations with coefficients – functions of relative credibility depending on solution dimensions. The obtained solutions depend on the parameter p in Lp metrics, parameter p being a balancing factor between the solution with the highest total utility and the solution with minimax deviations of criteria values from the ideal and negative-ideal solutions. If a unique solution is required, it

  19. Vulnerability assessment and penetration testing in the military and IHL context / Оценка уязвимости и тестирование на взлом в военном и международном гуманитарном праве / Procena ranjivosti i testiranje otpornosti na upade u sistem u vojnom i kontekstu međunarodnog humanitarnog prava

    Directory of Open Access Journals (Sweden)

    Dragan D. Mladenović

    2017-04-01

    снованных на тех же технологиях, и они одинаково важны как для управления рисками в военных операциях в киберпространстве, так и в области обороны, разведки и международного гуманитарного права. / Procena ranjivosti i testiranje otpornosti na upade u sistem su ključne aktivnosti upravljanja rizikom u informacionoj bezbednosti, sajber odbrani i obaveštajnom radu vojnih organizacija. Ove aktivnosti su značajne u kontekstu izvođenja vojnih operacija, ali i u kontekstu Međunarodnog humanitarnog prava (IHL i sprovođenja zakona. Primena informacionih tehnologija u vojnom i civilnom okruženju povećava kompleksnost u oblasti upravljanja rizikom. Pored informacione bezbednosti, vojne organizacije imaju zadatak da preduzmu neophodne aktivnosti u oblasti sajber operacija, za svrhe odbrane i napada. Oni zavise od znanja i veština zasnovanih na tehnologiji i implementiraju ih specifične organizacije u okviru vojnih sistema. Procena ranjivosti za cilj ima otkrivanje prirode ranjivosti, bez razmatranja kako se one mogu koristiti za napad, dok testiranje otpornosti na upade u sistem koristi eksploite za upade u sisteme i tako procenjuje vrstu i stepen rizika koji ove ranjivosti predstavljaju za sistem. Međutim, čak i ako predstavljaju dve različite aktivnosti, sa različitim krajnjim ciljevima, oni su komplementarni i međuzavisni. Pošto je njihova zajednička odlika razvoj znanja i veština zasnovanih na istim tehnologijama, oni su od podjednake važnosti za upravljanje rizikom, vojne operacije u sajber prostoru i njihovu upotrebu za odbrambene i obaveštajne aktivnosti, kao i međunarodno humanitarno pravo.

  20. Prikazi

    Directory of Open Access Journals (Sweden)

    Drahomira Gavranović

    2012-02-01

    zbornika jest i tema vlasništva pojedinog primjerka stare knjige. Upravo tu temu obradio je D. Shaw pod naslovom Tko je bio vlasnik ove knjige? Proučavanje porijekla knjiga u europskim razmjerima. Autor naglašava važnost katalogizacije na temelju pojedinog primjerka jer se jedino tako u kataložnom zapisu mogu zabilježiti sve karakteristike i posebnosti pojedinog primjerka građe. Upravo takav postupak opisa potaknuo je razvoj područja kojim se bavi autor u svome radu - proučavanja porijekla knjige. Važnost proučavanja prethodnih vlasnika jasno se vidi u mogućnosti okupljanja raspršenih knjižnica i privatnih zbirki koje svoju „pripadnost“ određenoj zbirci ponekad mogu dokazati jedino obilježjima vlasnika ili knjižnice kojoj su nekoć pripadali. Osim vlastoručnih potpisa vlasnika i pečata knjižnice, dokazi o prijašnjim vlasnicima mogu se istražiti i uz pomoć signatura, ex librisa, pečata na uvezima itd. Veliku pomoć u toj vrsti istraživanja pruža i Konzorcij europskih knjižnica (CERL koji nudi mrežnu bazu podataka o porijeklu knjiga. Posljednji rad u ovoj cjelini izradila je doktorska studentica M. Tomić pod naslovom Podaci o povijesti primjerka u hrvatskim katalozima stare i rijetke građe. Autorica je prikupila dostupne (tiskane kataloge te je kroz te kataloge i kataložne zapise starih i rijetkih knjiga u online katalozima istražila koliko se bilježe podaci o porijeklu primjerka. U radu su prikazani rezultati spomenutog istraživanja s posebnim osvrtom na podatke o povijesti primjerka ukoliko su (i ako su uopće uključeni u tiskane kataloge stare i rijetke građe u hrvatskim knjižnicama te u online katalozima hrvatskih knjižnica. Dodana vrijednost ovoga rada jest i bibliografija kataloga inkunabula, kataloga knjiga i rukopisa koji se nalaze u muzejskim knjižnicama i crkvenim ustanovama te kataloga izložbi starih i rijetkih knjiga. Neki od izvora koji su istraženi nisu ranije uključivani u postojeće bibliografije stare gra