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Sample records for soc system analysis

  1. Space Operations Center system analysis. Volume 3, book 2: SOC system definition report, revision A

    Science.gov (United States)

    1982-01-01

    The Space Operations Center (SOC) orbital space station program operations are described. A work breakdown structure for the general purpose support equipment, construction and transportation support, and resupply and logistics support systems is given. The basis for the design of each element is presented, and a mass estimate for each element supplied. The SOC build-up operation, construction, flight support, and satellite servicing operations are described. Detailed programmatics and cost analysis are presented.

  2. System on chip (SoC) microcontrollers (μC) as digitisers for ion beam analysis (IBA) instruments

    Energy Technology Data Exchange (ETDEWEB)

    Whitlow, Harry J., E-mail: harry.j@whitlow.se

    2016-09-15

    Data digitisation of the analogue signals from detectors to digital data is an essential process in ion beam analysis (IBA). The low-cost, easy availability and development environments that have a low learning threshold makes system-on-chip (SoC) microcontrollers (μC) attractive for this task. These μC combine, on one die, analogue and digital inputs and outputs with serial USB interfaces, which opens up simple implementation of tailor-made interfaces for specific IBA measurement systems. We have investigated the design and performance limitations based on development of three different digitisation interfaces for IBA. These were a two-channel nuclear instrumentation module (NIM) ADC event mode interface (EMI) for a high-resolution magnetic RBS spectrometer, a simple headless-multi-channel analyser (MCA) and a combined dual channel headless MCA and EMI. It is shown that SoC μC based interfaces for digitisation of analogue spectroscopy pulses in IBA systems can be implemented for material costs less than 100 €. The performance of the SoC devices for many IBA applications is close to what can be achieved with state-of-the-art instruments. The simple pulse spectroscopy interface circuit and software are included in the auxiliary archive.

  3. Process modeling of a reversible solid oxide cell (r-SOC) energy storage system utilizing commercially available SOC reactor

    International Nuclear Information System (INIS)

    Mottaghizadeh, Pegah; Santhanam, Srikanth; Heddrich, Marc P.; Friedrich, K. Andreas; Rinaldi, Fabio

    2017-01-01

    Highlights: • An electric energy storage system was developed based on a commercially available SOC reactor. • Heat generated in SOFC mode of r-SOC is utilized in SOEC operation of r-SOC using latent heat storage. • A round trip efficiency of 54.3% was reached for the reference system at atmospheric pressure. • An improved process system design achieved a round-trip efficiency of 60.4% at 25 bar. - Abstract: The increase of intermittent renewable energy contribution in power grids has urged us to seek means for temporal decoupling of electricity production and consumption. A reversible solid oxide cell (r-SOC) enables storage of surplus electricity through electrochemical reactions when it is in electrolysis mode. The reserved energy in form of chemical compounds is then converted to electricity when the cell operates as a fuel cell. A process system model was implemented using Aspen Plus® V8.8 based on a commercially available r-SOC reactor experimentally characterized at DLR. In this study a complete self-sustaining system configuration is designed by optimal thermal integration and balance of plant. Under reference conditions a round trip efficiency of 54.3% was achieved. Generated heat in fuel cell mode is exploited by latent heat storage tanks to enable endothermic operation of reactor in its electrolysis mode. In total, out of 100 units of thermal energy stored in heat storage tanks during fuel cell mode, 90% was utilized to offset heat demand of system in its electrolysis mode. Parametric analysis revealed the significance of heat storage tanks in thermal management even when reactor entered its exothermic mode of electrolysis. An improved process system design demonstrates a system round-trip efficiency of 60.4% at 25 bar.

  4. Study on SOC wavelet analysis for LiFePO4 battery

    Science.gov (United States)

    Liu, Xuepeng; Zhao, Dongmei

    2017-08-01

    Improving the prediction accuracy of SOC can reduce the complexity of the conservative and control strategy of the strategy such as the scheduling, optimization and planning of LiFePO4 battery system. Based on the analysis of the relationship between the SOC historical data and the external stress factors, the SOC Estimation-Correction Prediction Model based on wavelet analysis is established. Using wavelet neural network prediction model is of high precision to achieve forecast link, external stress measured data is used to update parameters estimation in the model, implement correction link, makes the forecast model can adapt to the LiFePO4 battery under rated condition of charge and discharge the operating point of the variable operation area. The test results show that the method can obtain higher precision prediction model when the input and output of LiFePO4 battery are changed frequently.

  5. Essential issues in SOC design designing complex systems-on-chip

    CERN Document Server

    Lin, Youn-long Steve

    2007-01-01

    Covers issues related to system-on-chip (SoC) design. This book covers IP development, verification, integration, chip implementation, testing and software. It contains valuable academic and industrial examples for those involved with the design of complex SOCs.

  6. NIRS as an alternative to conventional soil analysis for Greenland soils (focus on SOC)

    DEFF Research Database (Denmark)

    Knadel, Maria; Ogric, Mateja; Adhikari, Kabindra

    Soil organic carbon (SOC) is an important soil property. It is the main constituents of soil organic matter and a good indicator of soil quality. The estimation and mapping of SOC content could be used to select potential agricultural areas in the Arctic areas. However, conventional analysis of SOC...... are time consuming and expensive. They involve a lot of sample preparation, and chemicals and are destructive. Near infrared spectroscopy (NIRS) in the range between 400 and 2500 nm is an alternative method for SOC analysis. It is fast and non-destructive. The aims of this study where to test...... the feasibility of using NIRS to estimate SOC content on a landscape and field scale in Greenland. Partial Least squares regression models were built to correlated soil spectra and their reference SOC data to develop calibration models. Very good predictive ability for both landscape and field scale were obtained...

  7. TARGETED ANALYSIS OF JAK-STAT-SOCS GENES IN DAIRY CATTLE

    Directory of Open Access Journals (Sweden)

    Arun Sondur Jayappa

    2015-12-01

    Full Text Available The Janus kinase and signal transducer and activator of transcription (JAK-STAT pathway genes along with suppressors of cytokine signalling (SOCS family genes play a crucial role in controlling cytokine signals in the mammary gland and thus mammary gland development. Mammary gene expression studies showed differential expression patterns for all the JAK-STAT pathway genes. Gene expression studies using qRT-PCR revealed differential expression of SOCS2, SOCS4 and SOCS5 genes across the lactation cycle in dairy cows. Using genotypes from 1,546 Australian Holstein- Friesian bulls, a statistical model based on SNPs within 500kb of JAK-STAT pathway genes, and SOCS genes alone was carried out. The analysis suggested that these genes and pathways make a significant contribution to the Australian milk production traits. Selection of 24 SNPs close to SOCS1, SOCS3, SOCS5, SOCS7 and CISH genes were significantly associated with, Australian Profit Ranking (APR, Australian Selection Index (ASI and protein yield (PY. This study supports the view that there may be some merit in choosing SNPs around functionally relevant genes for the selection and genetic improvement schemes for dairy production traits.

  8. An acceleration system for Laplacian image fusion based on SoC

    Science.gov (United States)

    Gao, Liwen; Zhao, Hongtu; Qu, Xiujie; Wei, Tianbo; Du, Peng

    2018-04-01

    Based on the analysis of Laplacian image fusion algorithm, this paper proposes a partial pipelining and modular processing architecture, and a SoC based acceleration system is implemented accordingly. Full pipelining method is used for the design of each module, and modules in series form the partial pipelining with unified data formation, which is easy for management and reuse. Integrated with ARM processor, DMA and embedded bare-mental program, this system achieves 4 layers of Laplacian pyramid on the Zynq-7000 board. Experiments show that, with small resources consumption, a couple of 256×256 images can be fused within 1ms, maintaining a fine fusion effect at the same time.

  9. An ESL Approach for Energy Consumption Analysis of Cache Memories in SoC Platforms

    Directory of Open Access Journals (Sweden)

    Abel G. Silva-Filho

    2011-01-01

    Full Text Available The design of complex circuits as SoCs presents two great challenges to designers. One is the speeding up of system functionality modeling and the second is the implementation of the system in an architecture that meets performance and power consumption requirements. Thus, developing new high-level specification mechanisms for the reduction of the design effort with automatic architecture exploration is a necessity. This paper proposes an Electronic-System-Level (ESL approach for system modeling and cache energy consumption analysis of SoCs called PCacheEnergyAnalyzer. It uses as entry a high-level UML-2.0 profile model of the system and it generates a simulation model of a multicore platform that can be analyzed for cache tuning. PCacheEnergyAnalyzer performs static/dynamic energy consumption analysis of caches on platforms that may have different processors. Architecture exploration is achieved by letting designers choose different processors for platform generation and different mechanisms for cache optimization. PCacheEnergyAnalyzer has been validated with several applications of Mibench, Mediabench, and PowerStone benchmarks, and results show that it provides analysis with reduced simulation effort.

  10. Hardware-Assisted System for Program Execution Security of SOC

    Directory of Open Access Journals (Sweden)

    Wang Xiang

    2016-01-01

    Full Text Available With the rapid development of embedded systems, the systems’ security has become more and more important. Most embedded systems are at the risk of series of software attacks, such as buffer overflow attack, Trojan virus. In addition, with the rapid growth in the number of embedded systems and wide application, followed embedded hardware attacks are also increasing. This paper presents a new hardware assisted security mechanism to protect the program’s code and data, monitoring its normal execution. The mechanism mainly monitors three types of information: the start/end address of the program of basic blocks; the lightweight hash value in basic blocks and address of the next basic block. These parameters are extracted through additional tools running on PC. The information will be stored in the security module. During normal program execution, the security module is designed to compare the real-time state of program with the information in the security module. If abnormal, it will trigger the appropriate security response, suspend the program and jump to the specified location. The module has been tested and validated on the SOPC with OR1200 processor. The experimental analysis shows that the proposed mechanism can defence a wide range of common software and physical attacks with low performance penalties and minimal overheads.

  11. Advanced Technology for Ultra-Low Power System-on-Chip (SoC)

    Science.gov (United States)

    2017-06-01

    was proposed for lower power applications with Ioff=10pA/μm and VDD=0.5V. In this project, the optimized structure shows great potential in both Lg...AFRL-RY-WP-TR-2017-0115 ADVANCED TECHNOLOGY FOR ULTRA-LOW POWER SYSTEM-ON-CHIP (SoC) Jason Woo, Weicong Li, and Peng Lu University of California...September 2015 – 31 March 2017 4. TITLE AND SUBTITLE ADVANCED TECHNOLOGY FOR ULTRA-LOW POWER SYSTEM-ON- CHIP (SoC) 5a. CONTRACT NUMBER FA8650-15-1-7574 5b

  12. Stochastic Modeling and Performance Analysis of Multimedia SoCs

    DEFF Research Database (Denmark)

    Raman, Balaji; Nouri, Ayoub; Gangadharan, Deepak

    2013-01-01

    solutions where each modeling technique has both the above mentioned characteristics. We present a probabilistic analytical framework and a statistical model checking approach to design system-on-chips for low-cost multimedia systems. We apply the modeling techniques to size the output buffer in a video......Reliability and flexibility are among the key required features of a framework used to model a system. Existing approaches to design resource-constrained, soft-real time systems either provide guarantees for output quality or account for loss in the system, but not both. We propose two independent...... decoder. The results shows that, for our stochastic design metric, the analytical framework upper bounds (and relatively accurate) compare to the statistical model checking technique. Also, we observed significant reduction in resource usage (such as output buffer size) with tolerable loss in output...

  13. Algorithm & SoC design for automotive vision systems for smart safe driving system

    CERN Document Server

    Shin, Hyunchul

    2014-01-01

    An emerging trend in the automobile industry is its convergence with information technology (IT). Indeed, it has been estimated that almost 90% of new automobile technologies involve IT in some form. Smart driving technologies that improve safety as well as green fuel technologies are quite representative of the convergence between IT and automobiles. The smart driving technologies include three key elements: sensing of driving environments, detection of objects and potential hazards, and the generation of driving control signals including warning signals. Although radar-based systems are primarily used for sensing the driving environments, the camera has gained importance in advanced driver assistance systems(ADAS). This book covers system-on-a-chip (SoC) designs—including both algorithms and hardware—related with image sensing and object detection by using the camera for smart driving systems. It introduces a variety of algorithms such as lens correction, super resolution, image enhancement, and object ...

  14. The Immunohistochemical Analysis of SOCS3 Protein Identifies a Subgroup of Prostatic Cancer Biopsies With Aggressive Behavior.

    Science.gov (United States)

    Pierconti, Francesco; Martini, Maurizio; Cenci, Tonia; Larocca, Luigi M

    Recently, we demonstrated that hypermethylation of SOCS3 determines a significant reduction of its mRNA and protein expression and identifies a subgroup of prostate cancer with aggressive behavior. In this paper, our objective was to investigate whether the immunohistochemical expression of the SOCS3 protein could represent an alternative method to molecular analysis for the individualization of aggressive prostate carcinoma. We analyzed the SOCS3 immunohistochemical expression in 65 patients undergoing biopsies at the Institute of Urology of our hospital between September 2011 and October 2011 (median age, 66.4 y; range, 50 to 73 y), and in 35 cases, a subset of 65 cases originally used for the immunohistochemical study, we studied the methylation status of the SOCS3 promoter. We found that the percentage of cases with SOCS3 negativity (-) or with SOCS3 weak staining in <50% of the neoplastic glands (+/-) correlated to the worst prognosis in terms of the Gleason score (P=0.0001; Fisher's exact test), the pT stage (P=0.012; Fisher's exact test), and progression-free survival (P=0.0334; hazard ratio, 0.34; and 95% confidence interval, from 0.1261 to 0.9188). Moreover, some cases with an SOCS3 unmethylated pattern showed SOCS3-negative immunostaining (-) or SOCS3-negative glands with weak cytoplasmatic staining in <50% of the neoplastic glands (+/-). Our data suggest that in prostatic cancer biopsies, the immunohistochemical analysis of SOCS3 protein expression may provide a method that is less expensive and easier to apply than SOCS3 methylation analysis for the distinction of a subgroup of prostate cancer with a more aggressive behavior.

  15. Parametric dense stereovision implementation on a system-on chip (SoC).

    Science.gov (United States)

    Gardel, Alfredo; Montejo, Pablo; García, Jorge; Bravo, Ignacio; Lázaro, José L

    2012-01-01

    This paper proposes a novel hardware implementation of a dense recovery of stereovision 3D measurements. Traditionally 3D stereo systems have imposed the maximum number of stereo correspondences, introducing a large restriction on artificial vision algorithms. The proposed system-on-chip (SoC) provides great performance and efficiency, with a scalable architecture available for many different situations, addressing real time processing of stereo image flow. Using double buffering techniques properly combined with pipelined processing, the use of reconfigurable hardware achieves a parametrisable SoC which gives the designer the opportunity to decide its right dimension and features. The proposed architecture does not need any external memory because the processing is done as image flow arrives. Our SoC provides 3D data directly without the storage of whole stereo images. Our goal is to obtain high processing speed while maintaining the accuracy of 3D data using minimum resources. Configurable parameters may be controlled by later/parallel stages of the vision algorithm executed on an embedded processor. Considering hardware FPGA clock of 100 MHz, image flows up to 50 frames per second (fps) of dense stereo maps of more than 30,000 depth points could be obtained considering 2 Mpix images, with a minimum initial latency. The implementation of computer vision algorithms on reconfigurable hardware, explicitly low level processing, opens up the prospect of its use in autonomous systems, and they can act as a coprocessor to reconstruct 3D images with high density information in real time.

  16. A Cryptographic SoC for Robust Protection of Secret Keys in IPTV DRM Systems

    Science.gov (United States)

    Lee, Sanghan; Yang, Hae-Yong; Yeom, Yongjin; Park, Jongsik

    The security level of an internet protocol television (IPTV) digital right management (DRM) system ultimately relies on protection of secret keys. Well known devices for the key protection include smartcards and battery backup SRAMs (BB-SRAMs); however, these devices could be vulnerable to various physical attacks. In this paper, we propose a secure and cost-effective design of a cryptographic system on chip (SoC) that integrates the BB-SRAM with a cell-based design technique. The proposed SoC provides robust safeguard against the physical attacks, and satisfies high-speed and low-price requirements of IPTV set-top boxes. Our implementation results show that the maximum encryption rate of the SoC is 633Mb/s. In order to verify the data retention capabilities, we made a prototype chip using 0.18µm standard cell technology. The experimental results show that the integrated BB-SRAM can reliably retain data with a 1.4µA leakage current.

  17. Functional network analysis of genes differentially expressed during xylogenesis in soc1ful woody Arabidopsis plants.

    Science.gov (United States)

    Davin, Nicolas; Edger, Patrick P; Hefer, Charles A; Mizrachi, Eshchar; Schuetz, Mathias; Smets, Erik; Myburg, Alexander A; Douglas, Carl J; Schranz, Michael E; Lens, Frederic

    2016-06-01

    Many plant genes are known to be involved in the development of cambium and wood, but how the expression and functional interaction of these genes determine the unique biology of wood remains largely unknown. We used the soc1ful loss of function mutant - the woodiest genotype known in the otherwise herbaceous model plant Arabidopsis - to investigate the expression and interactions of genes involved in secondary growth (wood formation). Detailed anatomical observations of the stem in combination with mRNA sequencing were used to assess transcriptome remodeling during xylogenesis in wild-type and woody soc1ful plants. To interpret the transcriptome changes, we constructed functional gene association networks of differentially expressed genes using the STRING database. This analysis revealed functionally enriched gene association hubs that are differentially expressed in herbaceous and woody tissues. In particular, we observed the differential expression of genes related to mechanical stress and jasmonate biosynthesis/signaling during wood formation in soc1ful plants that may be an effect of greater tension within woody tissues. Our results suggest that habit shifts from herbaceous to woody life forms observed in many angiosperm lineages could have evolved convergently by genetic changes that modulate the gene expression and interaction network, and thereby redeploy the conserved wood developmental program. © 2016 The Authors. The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.

  18. Parametric Dense Stereovision Implementation on a System-on Chip (SoC

    Directory of Open Access Journals (Sweden)

    Pablo Montejo

    2012-02-01

    Full Text Available This paper proposes a novel hardware implementation of a dense recovery of stereovision 3D measurements. Traditionally 3D stereo systems have imposed the maximum number of stereo correspondences, introducing a large restriction on artificial vision algorithms. The proposed system-on-chip (SoC provides great performance and efficiency, with a scalable architecture available for many different situations, addressing real time processing of stereo image flow. Using double buffering techniques properly combined with pipelined processing, the use of reconfigurable hardware achieves a parametrisable SoC which gives the designer the opportunity to decide its right dimension and features. The proposed architecture does not need any external memory because the processing is done as image flow arrives. Our SoC provides 3D data directly without the storage of whole stereo images. Our goal is to obtain high processing speed while maintaining the accuracy of 3D data using minimum resources. Configurable parameters may be controlled by later/parallel stages of the vision algorithm executed on an embedded processor. Considering hardware FPGA clock of 100 MHz, image flows up to 50 frames per second (fps of dense stereo maps of more than 30,000 depth points could be obtained considering 2 Mpix images, with a minimum initial latency. The implementation of computer vision algorithms on reconfigurable hardware, explicitly low level processing, opens up the prospect of its use in autonomous systems, and they can act as a coprocessor to reconstruct 3D images with high density information in real time.

  19. Design of a Bidirectional Energy Storage System for a Vanadium Redox Flow Battery in a Microgrid with SOC Estimation

    Directory of Open Access Journals (Sweden)

    Qingwu Gong

    2017-03-01

    Full Text Available This paper used a Vanadium Redox flow Battery (VRB as the storage battery and designed a two-stage topology of a VRB energy storage system in which a phase-shifted full bridge dc-dc converter and three-phase inverter were used, considering the low terminal voltage of the VRB. Following this, a model of the VRB was simplified, according to the operational characteristics of the VRB in this designed topology of a VRB energy storage system (ESS. By using the simplified equivalent model of the VRB, the control parameters of the ESS were designed. For effectively estimating the state of charge (SOC of the VRB, a traditional method for providing the SOC estimation was simplified, and a simple and effective SOC estimation method was proposed in this paper. Finally, to illustrate the proper design of the VRB ESS and the proposed SOC estimation method, a corresponding simulation was designed by Simulink. The test results have demonstrated that this proposed SOC estimation method is feasible and effective for indicating the SOC of a VRB and the proper design of this VRB ESS is very reasonable for VRB applications.

  20. Monolithic distributed power management for systems-on-chip (SoC); Gestion monolithique distribuee de puissance pour les systemes sur puce (SOC)

    Energy Technology Data Exchange (ETDEWEB)

    Abedinpour, S. [Motorola, Semiconductor Products Sector, Tempe (United States); Bakkaloglu, B. [Texas Instruments, Broadband Communications Group, Dallas, Texas (United States); Kiaei, S. [Arizona State Univ., Connection one Research Center, Tempe (United States)

    2004-08-01

    With increasing drive towards higher level of integration, lower cost, and longer battery life in wireless applications, there is a need for efficient monolithic DC-DC power converters. This tutorial paper summarizes the topology tradeoffs that are involved in the implementation of monolithic distributed power management in the future generations of SoCs for portable wireless applications. These circuits have a broad range of requirements including high power density, high energy efficiency, low noise, small size, and low cost. The advantages and disadvantages of each of the competing topologies, namely low-dropout linear, switched capacitor, and switched-mode DC-DC converters are examined in light of these requirements. (authors)

  1. Analysis of Suppressor of Cytokine Signaling 2 Gene (SOCS2 Polymorphism in Different Dog Breeds

    Directory of Open Access Journals (Sweden)

    Martina Miluchová

    2011-05-01

    Full Text Available SOCS2 is a negative regulator of growth hormone signaling. The deletion of SOCS2 in mice results in a 30-50% increase in post-natal growth. The aim of the paper was to identify of suppressor of cytokine signaling 2 gene (SOCS2 polymorphism in different dog breeds. The material involved 77 dogs from 14 different breeds. Canine genomic DNA was isolated from saliva by modified method with using DNAzol® (Molecular Research Center and linear polyacrylamide (LPA carrier and from blood by using NucleospinBlood (Macherey-Nagel and used in order to estimate SOCS2 genotypes by PCR-RFLP method. The PCR products were digested with TaqI restriction enzyme. The T allele was distributed among large dog breeds (Czech pointer, Golden retriever, Rottweiler with an allele frequency ranging from 0.2857 to 1.00. In the population of Czech pointer we detected all genotypes. There were detected homozygote genotype GG with frequency 0.5476, heterozygote genotype GT with frequency 0.3333 and homozygote genotype TT with frequency 0.1191. Results point out that frequency of G allele was high and was represented 0.7143. Frequency of T allele was 0.2857. In Rottweiler was detected homozygote genotype TT. Genotypes GG and GT has not been observed. In Golden retriever we detected only heterozygote genotype GT.

  2. Rapid Development of System-on-Chip (SoC for Network-Enabled Visible Light Communications

    Directory of Open Access Journals (Sweden)

    Trio Adiono

    2018-03-01

    Full Text Available Visible Light Communication (VLC is an emerging optical communication technology with rapid development nowadays. VLC is considered as a compliment and successor of radio-frequency (RF wireless communication. There are various typical implementations of VLC in which one of them is for exchanging data TCP/IP packets, thus the user can browse the internet as in established Wireless fidelity (Wi-Fi technology. Briefly, we can call it by Light fidelity (Li-Fi. This paper described the design and implementation of System-on-Chip (SoC subsystem for Li-Fi application where the implemented SoC consists of hardware (H/W and software (S/W. In the H/W aspect, Physical Layer (PHY is made by using UART communication with Ethernet connection to communicate with Host/Device personal-computer (PC. In the S/W aspect, Xillinux operating system (OS is used. The H/W- as well as S/W-SoC, are realized in FPGA Zybo Zynq-7000 EPP development board. The functional test result shows (without optical channel or Zybo-to-Zybo only that the implemented SoC is working as expected. It is able to exchange TCP/IP packets between two PCs. Moreover, Ethernet connection has bandwidth up to 83.6 Mbps and PHY layer baud rate has bandwidth up to 921600 bps.

  3. Assessing SOC labile fractions through respiration test, density-size fractionation and thermal analysis - A comparison of methods

    Science.gov (United States)

    Soucemarianadin, Laure; Cécillon, Lauric; Chenu, Claire; Baudin, François; Nicolas, Manuel; Savignac, Florence; Barré, Pierre

    2017-04-01

    Soil organic matter (SOM) is the biggest terrestrial carbon reservoir, storing 3 to 4 times more carbon than the atmosphere. However, despite its major importance for climate regulation SOM dynamics remains insufficiently understood. For instance, there is still no widely accepted method to assess SOM lability. Soil respiration tests and particulate organic matter (POM) obtained by different fractionation schemes have been used for decades and are now considered as classical estimates of very labile and labile soil organic carbon (SOC), respectively. But the pertinence of these methods to characterize SOM turnover can be questioned. Moreover, they are very time-consuming and their reproducibility might be an issue. Alternate ways of determining the labile SOC component are thus well-needed. Thermal analyses have been used to characterize SOM among which Rock-Eval 6 (RE6) analysis of soil has shown promising results in the determination of SOM biogeochemical stability (Gregorich et al., 2015; Barré et al., 2016). Using a large set of samples of French forest soils representing contrasted pedoclimatic conditions, including deep samples (up to 1 m depth), we compared different techniques used for SOM lability assessment. We explored whether results from soil respiration test (10-week laboratory incubations), SOM size-density fractionation and RE6 thermal analysis were comparable and how they were correlated. A set of 222 (respiration test and RE6), 103 (SOM fractionation and RE6) and 93 (respiration test, SOM fractionation and RE6) forest soils samples were respectively analyzed and compared. The comparison of the three methods (n = 93) using a principal component analysis separated samples from the surface (0-10 cm) and deep (40-80 cm) layers, highlighting a clear effect of depth on the short-term persistence of SOC. A correlation analysis demonstrated that, for these samples, the two classical methods of labile SOC determination (respiration and SOM fractionation

  4. Community Readiness Within Systems of Care: The Validity and Reliability of the System of Care Readiness and Implementation Measurement Scale (SOC-RIMS).

    Science.gov (United States)

    Rosas, Scott R; Behar, Lenore B; Hydaker, William M

    2016-01-01

    Establishing a system of care requires communities to identify ways to successfully implement strategies and support positive outcomes for children and their families. Such community transformation is complex and communities vary in terms of their readiness for implementing sustainable community interventions. Assessing community readiness and guiding implementation, specifically for the funded communities implementing a system of care, requires a well-designed tool with sound psychometric properties. This scale development study used the results of a previously published concept mapping study to create, administer, and assess the psychometric characteristics of the System of Care Readiness and Implementation Measurement Scale (SOC-RIMS). The results indicate the SOC-RIMS possesses excellent internal consistency characteristics, measures clearly discernible dimensions of community readiness, and demonstrates the target constructs exist within a broad network of content. The SOC-RIMS can be a useful part of a comprehensive assessment in communities where system of care practices, principles, and philosophies are implemented and evaluated.

  5. Development of control system for multi-converter High voltage Power supply using programmable SoC

    Science.gov (United States)

    Dave, Rasesh; Dharangutti, Jagruti; Singh, N. P.; Thakar, Aruna; Dhola, Hitesh; Gajjar, Sandip; Parmar, Darshan; Zaveri, Tanish; Baruah, Ujjwal

    2017-04-01

    Multi-converter based High Voltage Power Supplies (HVPSs) find application in multi-megawatt accelerators, RF systems. Control system for HVPS must be a combination of superior parallel processing, real time performance, fast computation and versatile connectivity. The hardware platform is expected to be robust, easily scalable for future developments with minimal overheads. This paper describes development of control system on Zynq All Programmable SoC (System on Chip) for HVPS. Typical HVPS control mechanism involves communication, generation of precise control signals/pulses for few hundred numbers of chopper and closed loop control in microsecond range for regulated output. Such kind of requirements can be met with Zynq All Programmable SoC, which is a combination of Dual core ARM Cortex A-9 Processing System (PS) and Xilinx 7 series FPGA based Programmable Logic (PL). Deterministic functions of power supply control system such as generation of control signals with precise inter-channel delay of nanosecond range and communication with individual chopper at 100kbps can be implemented on PL. PS should implement corrective tasks based on field feedback received from individual chopper, user interface and OS management that allows to take full advantage of system capabilities. PS and PL are connected with on-chip AXI-4 interface with low latency and higher bandwidth through 9 AXI ports. Typically PS boots first, this ensures secure booting and prevents external environment from tampering PL.

  6. Development of control system for multi-converter high voltage power supply using programmable SoC

    International Nuclear Information System (INIS)

    Dave, Rasesh; Singh, N.P.; Thakar, Aruna; Dhola, Hitesh; Gajjar, Sandip; Parmar, Darshan Kumar; Baruah, Ujjwal Kumar; Dharangutti, Jagruti; Zaveri, Tanish

    2015-01-01

    Multi-converter based High Voltage Power Supplies (HVPSs) find application in multi-megawatt accelerators, RF systems. Control system for HVPS must be a combination of superior parallel processing, real time performance, fast computation and versatile connectivity. The hardware platform is expected to be robust, easily scalable for future developments without any cost overhead. Typical HVPS control mechanism involves communication, generation of precise control signals/pulses for few hundred Nos of chopper and closed loop control in microsecond range for regulated output. Such kind of requirements can be met with Zynq All Programmable SoC, which is a combination of Dual core ARM Cortex A-9 Processing System (PS) and Xilinx 7 series FPGA based Programmable Logic (PL). Deterministic functions of power supply control system such as generation of control signals with precise inter-channel delay of nanosecond range and communication with individual chopper at 100kbps can be implemented on PL. PS should implement corrective tasks based on field feedback received from individual chopper, user interface and OS management that allows to take full advantage of system capabilities. PS and PL are connected with on-chip AXI-4 interface with low latency and higher bandwidth through 9 AXI ports. Typically PS boots first, this ensures secure booting and prevents external environment from tampering PL. This paper describes development of control system on Zynq All Programmable SoC for HVPS. (author)

  7. Rock-Eval analysis of French forest soils: the influence of depth, soil and vegetation types on SOC thermal stability and bulk chemistry

    Science.gov (United States)

    Soucemarianadin, Laure; Cécillon, Lauric; Baudin, François; Cecchini, Sébastien; Chenu, Claire; Mériguet, Jacques; Nicolas, Manuel; Savignac, Florence; Barré, Pierre

    2017-04-01

    Soil organic matter (SOM) is the largest terrestrial carbon pool and SOM degradation has multiple consequences on key ecosystem properties like nutrients cycling, soil emissions of greenhouse gases or carbon sequestration potential. With the strong feedbacks between SOM and climate change, it becomes particularly urgent to develop reliable routine methodologies capable of indicating the turnover time of soil organic carbon (SOC) stocks. Thermal analyses have been used to characterize SOM and among them, Rock-Eval 6 (RE6) analysis of soil has shown promising results in the determination of in-situ SOC biogeochemical stability. This technique combines a phase of pyrolysis followed by a phase of oxidation to provide information on both the SOC bulk chemistry and thermal stability. We analyzed with RE6 a set of 495 soils samples from 102 permanent forest sites of the French national network for the long-term monitoring of forest ecosystems (''RENECOFOR'' network). Along with covering pedoclimatic variability at a national level, these samples include a range of 5 depths up to 1 meter (0-10 cm, 10-20 cm, 20-40 cm, 40-80 cm and 80-100 cm). Using RE6 parameters that were previously shown to be correlated to short-term (hydrogen index, HI; T50 CH pyrolysis) or long-term (T50 CO2 oxidation and HI) SOC persistence, and that characterize SOM bulk chemical composition (oxygen index, OI and HI), we tested the influence of depth (n = 5), soil class (n = 6) and vegetation type (n = 3; deciduous, coniferous-fir, coniferous-pine) on SOM thermal stability and bulk chemistry. Results showed that depth was the dominant discriminating factor, affecting significantly all RE6 parameters. With depth, we observed a decrease of the thermally labile SOC pool and an increase of the thermally stable SOC pool, along with an oxidation and a depletion of hydrogen-rich moieties of the SOC. Soil class and vegetation type had contrasted effects on the RE6 parameters but both affected significantly T

  8. High organic inputs explain shallow and deep SOC storage in a long-term agroforestry system – combining experimental and modeling approaches

    Directory of Open Access Journals (Sweden)

    R. Cardinael

    2018-01-01

    Full Text Available Agroforestry is an increasingly popular farming system enabling agricultural diversification and providing several ecosystem services. In agroforestry systems, soil organic carbon (SOC stocks are generally increased, but it is difficult to disentangle the different factors responsible for this storage. Organic carbon (OC inputs to the soil may be larger, but SOC decomposition rates may be modified owing to microclimate, physical protection, or priming effect from roots, especially at depth. We used an 18-year-old silvoarable system associating hybrid walnut trees (Juglans regia  ×  nigra and durum wheat (Triticum turgidum L. subsp. durum and an adjacent agricultural control plot to quantify all OC inputs to the soil – leaf litter, tree fine root senescence, crop residues, and tree row herbaceous vegetation – and measured SOC stocks down to 2 m of depth at varying distances from the trees. We then proposed a model that simulates SOC dynamics in agroforestry accounting for both the whole soil profile and the lateral spatial heterogeneity. The model was calibrated to the control plot only. Measured OC inputs to soil were increased by about 40 % (+ 1.11 t C ha−1 yr−1 down to 2 m of depth in the agroforestry plot compared to the control, resulting in an additional SOC stock of 6.3 t C ha−1 down to 1 m of depth. However, most of the SOC storage occurred in the first 30 cm of soil and in the tree rows. The model was strongly validated, properly describing the measured SOC stocks and distribution with depth in agroforestry tree rows and alleys. It showed that the increased inputs of fresh biomass to soil explained the observed additional SOC storage in the agroforestry plot. Moreover, only a priming effect variant of the model was able to capture the depth distribution of SOC stocks, suggesting the priming effect as a possible mechanism driving deep SOC dynamics. This result questions the potential of soils to

  9. High organic inputs explain shallow and deep SOC storage in a long-term agroforestry system - combining experimental and modeling approaches

    Science.gov (United States)

    Cardinael, Rémi; Guenet, Bertrand; Chevallier, Tiphaine; Dupraz, Christian; Cozzi, Thomas; Chenu, Claire

    2018-01-01

    Agroforestry is an increasingly popular farming system enabling agricultural diversification and providing several ecosystem services. In agroforestry systems, soil organic carbon (SOC) stocks are generally increased, but it is difficult to disentangle the different factors responsible for this storage. Organic carbon (OC) inputs to the soil may be larger, but SOC decomposition rates may be modified owing to microclimate, physical protection, or priming effect from roots, especially at depth. We used an 18-year-old silvoarable system associating hybrid walnut trees (Juglans regia × nigra) and durum wheat (Triticum turgidum L. subsp. durum) and an adjacent agricultural control plot to quantify all OC inputs to the soil - leaf litter, tree fine root senescence, crop residues, and tree row herbaceous vegetation - and measured SOC stocks down to 2 m of depth at varying distances from the trees. We then proposed a model that simulates SOC dynamics in agroforestry accounting for both the whole soil profile and the lateral spatial heterogeneity. The model was calibrated to the control plot only. Measured OC inputs to soil were increased by about 40 % (+ 1.11 t C ha-1 yr-1) down to 2 m of depth in the agroforestry plot compared to the control, resulting in an additional SOC stock of 6.3 t C ha-1 down to 1 m of depth. However, most of the SOC storage occurred in the first 30 cm of soil and in the tree rows. The model was strongly validated, properly describing the measured SOC stocks and distribution with depth in agroforestry tree rows and alleys. It showed that the increased inputs of fresh biomass to soil explained the observed additional SOC storage in the agroforestry plot. Moreover, only a priming effect variant of the model was able to capture the depth distribution of SOC stocks, suggesting the priming effect as a possible mechanism driving deep SOC dynamics. This result questions the potential of soils to store large amounts of carbon, especially at depth. Deep

  10. Identification of suppressor of cytokine signalling (SOCS) 6, 7, 9 and CISH in rainbow trout Oncorhynchus mykiss and analysis of their expression in relation to other known trout SOCS.

    Science.gov (United States)

    Wang, Tiehui; Gao, Qian; Nie, Pin; Secombes, Christopher J

    2010-10-01

    Four new members of the SOCS family of molecules in rainbow trout (Oncorhynchus mykiss), CISH and SOCS6, 7 and 9, are described for the first time in this species. The genes had a wide tissue distribution in trout, and were detected in gills, skin, muscle, liver, spleen, head kidney, intestine and brain, with brain having the highest expression levels. Stimulation of a rainbow trout leucocyte cell line, RTS-11, (mononuclear/macrophage-like cells) with LPS or Poly I:C had no effect on the expression of these genes, although in both cases the previously identified SOCS1-3 genes were up-regulated. Similarly, stimulation of RTS-11 or RTG-2 (fibroblasts) cells with the trout recombinant cytokines IFN-gamma or IL-1beta had no effect on CISH or SOCS6, 7 and 9 expression. However, PMA stimulation did impact on SOCS6 and SOCS9 expression, and LPS stimulation of primary cultures or bacterial infection (Yersinia ruckeri) increased significantly CISH expression (as well as SOCS1 and SOCS2 or SOCS3 respectively). It is apparent that the type II SOCS genes (CISH, SOCS1-3) are particularly relevant to immune regulation in fish, although the intriguing expansion of the SOCS4/5 subgroup in fish requires further investigation as to their role and functional divergence. Copyright 2010 Elsevier Ltd. All rights reserved.

  11. Analysis of the internal temperature of the cells in a battery pack during SOC balancing

    Science.gov (United States)

    Mizanur, R.; Rashid, M. M.; Rahman, A.; Zahirul Alam, A. H. M.; Ihsan, S.; Mollik, M. S.

    2017-03-01

    Lithium-ion batteries are more suitable for the application of electric vehicle due to high energy and power density compared to other rechargeable batteries. However, the battery pack temperature has a great impact on the overall performance, cycle life, normal charging-discharging behaviour and even safety. During rapid charge transferring process, the internal temperature may exceed its allowable limit (460C). In this paper, an analysis of internal temperature during charge balancing and discharging conditions is presented. Specific interest is paid to the effects of temperature on the different rate of ambient temperature and discharging current. Matlab/Simulink Li-ion battery model and quasi-resonant converter base balancing system are used to study the temperature effect. Rising internal temperature depends on the rate of balancing current and ambient temperature found in the simulation results.

  12. Sticker-type ECG/PPG concurrent monitoring system hybrid integration of CMOS SoC and organic sensor device.

    Science.gov (United States)

    Yongsu Lee; Hyeonwoo Lee; Seunghyup Yoo; Hoi-Jun Yoo

    2016-08-01

    The sticker-type sensor system is proposed targeting ECG/PPG concurrent monitoring for cardiovascular diseases. The stickers are composed of two types: Hub and Sensor-node (SN) sticker. Low-power CMOS SoC for measuring ECG and PPG signal is hybrid integrated with organic light emitting diodes (OLEDs) and organic photo detector (OPD). The sticker has only 2g weight and only consumes 141μW. The optical calibration loop is adopted for maintaining SNR of PPG signal higher than 30dB. The pulse arrival time (PAT) and SpO2 value can be extracted from various body parts and verified comparing with the reference device from 20 people in-vivo experiments.

  13. Calcineurin inhibitor-induced complement system activation via ERK1/2 signalling is inhibited by SOCS-3 in human renal tubule cells.

    Science.gov (United States)

    Loeschenberger, Beatrix; Niess, Lea; Würzner, Reinhard; Schwelberger, Hubert; Eder, Iris E; Puhr, Martin; Guenther, Julia; Troppmair, Jakob; Rudnicki, Michael; Neuwirt, Hannes

    2018-02-01

    One factor that significantly contributes to renal allograft loss is chronic calcineurin inhibitor (CNI) nephrotoxicity (CIN). Among other factors, the complement (C-) system has been proposed to be involved CIN development. Hence, we investigated the impact of CNIs on intracellular signalling and the effects on the C-system in human renal tubule cells. In a qPCR array, CNI treatment upregulated C-factors and downregulated SOCS-3 and the complement inhibitors CD46 and CD55. Additionally, ERK1/-2 was required for these regulations. Following knock-down and overexpression of SOCS-3, we found that SOCS-3 inhibits ERK1/-2 signalling. Finally, we assessed terminal complement complex formation, cell viability and apoptosis. Terminal complement complex formation was induced by CNIs. Cell viability was significantly decreased, whereas apoptosis was increased. Both effects were reversed under complement component-depleted conditions. In vivo, increased ERK1/-2 phosphorylation and SOCS-3 downregulation were observed at the time of transplantation in renal allograft patients who developed a progressive decline of renal function in the follow-up compared to stable patients. The progressive cohort also had lower total C3 levels, suggesting higher complement activity at baseline. In conclusion, our data suggest that SOCS-3 inhibits CNI-induced ERK1/-2 signalling, thereby blunting the negative control of C-system activation. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Systems-on-Chip (SoC) for applications in High-Energy Physics

    CERN Document Server

    De Gaspari, Massimiliano; Fischer, Peter

    In view of the Time Projection Chamber for the future Linear Collider (LCTPC), a new front-end Application-Specic Integrated Circuit has been developed: the 16 channels Super-Altro Demonstrator. Given the small pad area of $1 \\times 4mm^{2}$, the chip is a compact integrated system, including signal preamplifcation/shaping, 10-bit analog-to-digital conversion and digital signal processing. Adequate design techniques were used to reduce noise coupling between analog and digital parts of the system. The bunch train structure of the linear collider is exploited by the introduction of power pulsing features in the design, which result in a signicant reduction of the power consumption. The tests carried out show noise as low as 316 electrons and effectiveness of the power pulsing approach. Super-Altro can be used for studies of gaseous detector readout with classical wire chambers as well as modern GEMs and MicroMegas. This thesis also studies Analog-to-Digital Converters (ADC) suitable for integration in High-Ene...

  15. Interleaved Subtask Scheduling on Multi Processor SOC

    NARCIS (Netherlands)

    Zhe, M.

    2006-01-01

    The ever-progressing semiconductor processing technique has integrated more and more embedded processors on a single system-on-achip (SoC). With such powerful SoC platforms, and also due to the stringent time-to-market deadlines, many functionalities which used to be implemented in ASICs are

  16. A 6.45 μW Self-Powered SoC With Integrated Energy-Harvesting Power Management and ULP Asymmetric Radios for Portable Biomedical Systems.

    Science.gov (United States)

    Roy, Abhishek; Klinefelter, Alicia; Yahya, Farah B; Chen, Xing; Gonzalez-Guerrero, Luisa Patricia; Lukas, Christopher J; Kamakshi, Divya Akella; Boley, James; Craig, Kyle; Faisal, Muhammad; Oh, Seunghyun; Roberts, Nathan E; Shakhsheer, Yousef; Shrivastava, Aatmesh; Vasudevan, Dilip P; Wentzloff, David D; Calhoun, Benton H

    2015-12-01

    This paper presents a batteryless system-on-chip (SoC) that operates off energy harvested from indoor solar cells and/or thermoelectric generators (TEGs) on the body. Fabricated in a commercial 0.13 μW process, this SoC sensing platform consists of an integrated energy harvesting and power management unit (EH-PMU) with maximum power point tracking, multiple sensing modalities, programmable core and a low power microcontroller with several hardware accelerators to enable energy-efficient digital signal processing, ultra-low-power (ULP) asymmetric radios for wireless transmission, and a 100 nW wake-up radio. The EH-PMU achieves a peak end-to-end efficiency of 75% delivering power to a 100 μA load. In an example motion detection application, the SoC reads data from an accelerometer through SPI, processes it, and sends it over the radio. The SPI and digital processing consume only 2.27 μW, while the integrated radio consumes 4.18 μW when transmitting at 187.5 kbps for a total of 6.45 μW.

  17. 60 GHz system-on-chip (SoC) with built-in memory and an on-chip antenna

    KAUST Repository

    Ghaffar, Farhan A.; Arsalan, Muhammad; Cheema, Hammad; Salama, Khaled N.; Shamim, Atif

    2014-01-01

    A novel 60 GHz transmitter SoC with an on-chip antenna and integrated memory in CMOS 65 nm technology is presented in this paper. This highly integrated transmitter design can support a data rate of 2 GBPS with a transmission range of 1 m. The transmitter consists of a fundamental frequency 60 GHz PLL which covers the complete ISM band. The modulator following the PLL can support both BPSK and OOK modulation schemes. Both stored data on the integrated memory or directly from an external source can be transmitted. A tapered slot on chip antenna is integrated with the power amplifier to complete the front end of the transmitter design. Size of the complete transmitter with on-chip antenna is only 1.96 mm × 1.96 mm. The core circuits consume less than 100 mW of power. The high data rate capability of the design makes it extremely suitable for bandwidth hungry applications such as unencrypted HD video streaming and transmission.

  18. 60 GHz system-on-chip (SoC) with built-in memory and an on-chip antenna

    KAUST Repository

    Ghaffar, Farhan A.

    2014-04-01

    A novel 60 GHz transmitter SoC with an on-chip antenna and integrated memory in CMOS 65 nm technology is presented in this paper. This highly integrated transmitter design can support a data rate of 2 GBPS with a transmission range of 1 m. The transmitter consists of a fundamental frequency 60 GHz PLL which covers the complete ISM band. The modulator following the PLL can support both BPSK and OOK modulation schemes. Both stored data on the integrated memory or directly from an external source can be transmitted. A tapered slot on chip antenna is integrated with the power amplifier to complete the front end of the transmitter design. Size of the complete transmitter with on-chip antenna is only 1.96 mm × 1.96 mm. The core circuits consume less than 100 mW of power. The high data rate capability of the design makes it extremely suitable for bandwidth hungry applications such as unencrypted HD video streaming and transmission.

  19. NTP Radioisotopes SOC Ltd

    International Nuclear Information System (INIS)

    Letule, T.

    2017-01-01

    NTP Radioisotopes SOC Ltd, a wholly owned subsidiary of the South African Nuclear Energy Corporation (NECSA). Supplies around 20% of the world's medical radioisotopes used. NTP is a pioneer in the introduction and growth of nuclear medicine as in South Africa. Nuclear medicine is the medical specialty that involves the use of radioactive isotopes in the diagnosis and treatment of diseases. Nuclear medicine contributes to enhancing the lives of the society. There is a compelling need for nuclear medicine to be promoted and utilized in the rest of Africa, due to the increasing prevalence of cancer. Cancer is rapidly becoming a public health crisis in low-income and middle-income countries. In sub-Saharan Africa, patients often present with advanced disease

  20. Variation tolerant SoC design

    Science.gov (United States)

    Kozhikkottu, Vivek J.

    performance distribution. This task is particularly complex and challenging due to the inter-dependencies between components' execution, indirect effects of shared resources, and interactions between multiple system-level "execution paths". We argue that accurate variation-aware performance analysis requires Monte-Carlo based repeated system execution. Our proposed analysis framework leverages emulation to significantly speedup performance analysis without sacrificing the generality and accuracy achieved by Monte-Carlo based simulations. Our experiments show performance improvements of around 60x compared to state-of-the-art hardware-software co-simulation tools and also underscore the framework's potential to enable variation-aware design and exploration at the system level. Our second contribution addresses the problem of designing variation-tolerant SoCs using recovery based design, a popular circuit design paradigm that addresses variations by eliminating guard-bands and operating circuits at close to "zero margins" while detecting and recovering from timing errors. While previous efforts have demonstrated the potential benefits of recovery based design, we identify several challenges that need to be addressed in order to apply this technique to SoCs. We present a systematic design framework to apply recovery based design at the system level. We propose to partition SoCs into "recovery islands", wherein each recovery island consists of one or more SoC components that can recover independent of the rest of the SoC. We present a variation-aware design methodology that partitions a given SoC into recovery islands and computes the optimal operating points for each island, taking into account the various trade-offs involved. Our experiments demonstrate that the proposed design framework achieves an average of 32% energy savings over conventional worst-case designs, with negligible losses in performance. The third contribution of this thesis introduces disproportionate

  1. Rapid Industrial Prototyping and SoC Design of 3G/4G Wireless Systems Using an HLS Methodology

    Directory of Open Access Journals (Sweden)

    Andres Takach

    2006-07-01

    Full Text Available Many very-high-complexity signal processing algorithms are required in future wireless systems, giving tremendous challenges to real-time implementations. In this paper, we present our industrial rapid prototyping experiences on 3G/4G wireless systems using advanced signal processing algorithms in MIMO-CDMA and MIMO-OFDM systems. Core system design issues are studied and advanced receiver algorithms suitable for implementation are proposed for synchronization, MIMO equalization, and detection. We then present VLSI-oriented complexity reduction schemes and demonstrate how to interact these high-complexity algorithms with an HLS-based methodology for extensive design space exploration. This is achieved by abstracting the main effort from hardware iterations to the algorithmic C/C++ fixed-point design. We also analyze the advantages and limitations of the methodology. Our industrial design experience demonstrates that it is possible to enable an extensive architectural analysis in a short-time frame using HLS methodology, which significantly shortens the time to market for wireless systems.

  2. Rapid Industrial Prototyping and SoC Design of 3G/4G Wireless Systems Using an HLS Methodology

    Directory of Open Access Journals (Sweden)

    Cavallaro JosephR

    2006-01-01

    Full Text Available Many very-high-complexity signal processing algorithms are required in future wireless systems, giving tremendous challenges to real-time implementations. In this paper, we present our industrial rapid prototyping experiences on 3G/4G wireless systems using advanced signal processing algorithms in MIMO-CDMA and MIMO-OFDM systems. Core system design issues are studied and advanced receiver algorithms suitable for implementation are proposed for synchronization, MIMO equalization, and detection. We then present VLSI-oriented complexity reduction schemes and demonstrate how to interact these high-complexity algorithms with an HLS-based methodology for extensive design space exploration. This is achieved by abstracting the main effort from hardware iterations to the algorithmic C/C++ fixed-point design. We also analyze the advantages and limitations of the methodology. Our industrial design experience demonstrates that it is possible to enable an extensive architectural analysis in a short-time frame using HLS methodology, which significantly shortens the time to market for wireless systems.

  3. Real-Time Control System for Improved Precision and Throughput in an Ultrafast Carbon Fiber Placement Robot Using a SoC FPGA Extended Processing Platform

    Directory of Open Access Journals (Sweden)

    Gilberto Ochoa-Ruiz

    2017-01-01

    Full Text Available We present an architecture for accelerating the processing and execution of control commands in an ultrafast fiber placement robot. The system consists of a robotic arm designed by Coriolis Composites whose purpose is to move along a surface, on which composite fibers are deposed, via an independently controlled head. In first system implementation, the control commands were sent via Profibus by a PLC, limiting the reaction time and thus the precision of the fiber placement and the maximum throughput. Therefore, a custom real-time solution was imperative in order to ameliorate the performance and to meet the stringent requirements of the target industry (avionics, aeronautical systems. The solution presented in this paper is based on the use of a SoC FPGA processing platform running a real-time operating system (FreeRTOS, which has enabled an improved comamnd retrieval mechanism. The system’s placement precision was improved by a factor of 20 (from 1 mm to 0.05 mm, while the maximum achievable throughput was 1 m/s, compared to the average 30 cm/s provided by the original solution, enabling fabricating more complex and larger pieces in a significant fraction of the time.

  4. SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome.

    Science.gov (United States)

    Vuong, Bao Q; Arenzana, Teresita L; Showalter, Brian M; Losman, Julie; Chen, X Peter; Mostecki, Justin; Banks, Alexander S; Limnander, Andre; Fernandez, Neil; Rothman, Paul B

    2004-10-01

    The regulation of cytokine signaling is critical for controlling cellular proliferation and activation during an immune response. SOCS-1 is a potent inhibitor of Jak kinase activity and of signaling initiated by several cytokines. SOCS-1 protein levels are tightly regulated, and recent data suggest that SOCS-1 may regulate the protein levels of some signaling proteins by the ubiquitin proteasome pathway; however, the cellular mechanism by which SOCS-1 directs proteins for degradation is unknown. In this report, SOCS-1 is found to colocalize and biochemically copurify with the microtubule organizing complex (MTOC) and its associated 20S proteasome. The SOCS-1 SH2 domain is required for the localization of SOCS-1 to the MTOC. Overexpression of SOCS-1 targets Jak1 in an SH2-dependent manner to a perinuclear distribution resembling the MTOC-associated 20S proteasome. Analysis of MTOCs fractionated from SOCS-1-deficient cells demonstrates that SOCS-1 may function redundantly to regulate the localization of Jak1 to the MTOC. Nocodazole inhibits the protein turnover of SOCS-1, demonstrating that the minus-end transport of SOCS-1 to the MTOC-associated 20S proteasome is required to regulate SOCS-1 protein levels. These data link SOCS-1 directly with the proteasome pathway and suggest another function for the SH2 domain of SOCS-1 in the regulation of Jak/STAT signaling.

  5. Fundamentals of IP and SoC security design, verification, and debug

    CERN Document Server

    Ray, Sandip; Sur-Kolay, Susmita

    2017-01-01

    This book is about security in embedded systems and it provides an authoritative reference to all aspects of security in system-on-chip (SoC) designs. The authors discuss issues ranging from security requirements in SoC designs, definition of architectures and design choices to enforce and validate security policies, and trade-offs and conflicts involving security, functionality, and debug requirements. Coverage also includes case studies from the “trenches” of current industrial practice in design, implementation, and validation of security-critical embedded systems. Provides an authoritative reference and summary of the current state-of-the-art in security for embedded systems, hardware IPs and SoC designs; Takes a "cross-cutting" view of security that interacts with different design and validation components such as architecture, implementation, verification, and debug, each enforcing unique trade-offs; Includes high-level overview, detailed analysis on implementation, and relevant case studies on desi...

  6. Research on SOC Calibration of Large Capacity Lead Acid Battery

    Science.gov (United States)

    Ye, W. Q.; Guo, Y. X.

    2018-05-01

    Large capacity lead-acid battery is used in track electric locomotive, and State of Charge (SOC) is an important quantitative parameter of locomotive power output and operating mileage of power emergency recovery vehicle. But State of Charge estimation has been a difficult part in the battery management system. In order to reduce the SOC estimation error better, this paper uses the linear relationship of Open Circuit Voltage (OCV) and State of Charge to fit the SOC-OCV curve equation by MATLAB. The method proposed in this paper is small, easy to implement and can be used in the battery non-working state SOC estimation correction, improve the estimation accuracy of SOC.

  7. Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm.

    Science.gov (United States)

    Zhang, Min Yue; Fung, Tsz Kin; Chen, Fang Yuan; Chim, Chor Sang

    2013-10-01

    Janus kinase-signal transducer and activator of transcription (JAK/STAT) signalling, pivotal in Philadelphia-negative (Ph-ve) myeloproliferative neoplasm (MPN), is negatively regulated by molecules including SOCSs, CISH and SHP1. SOCS1, SOCS2 and SOCS3 methylation have been studied in MPN with discordant results. Herein, we studied the methylation status of SOCS1, SOCS2 and SOCS3, CISH and SHP1 by methylation-specific polymerase chain reaction (MSP) in cell lines and 45 diagnostic marrow samples of Ph-ve MPN. Moreover, we attempted to explain the discordance of methylation frequency by mapping the studied MSP primers to the respective genes. Methylation was detected in normal controls using SOCS2 MSP primers in the 3'translated exonic sequence, but not primers around the transcription start site in the 5' untranslated regions (5'UTR). SOCS1, SOCS2, SOCS3 and CISH were completely unmethylated in primary MPN samples and cell lines. In contrast, methylation of SHP1 was detected in 8.9% primary marrow samples. Moreover, SHP1 was completely methylated in K562 cell line, leading to reversible SHP1 silencing. A review of methylation studies of SOCS1 and SOCS3 showed that spuriously high rates of SOCS methylation had been reported using MSP primers targeting CpG sites in the 3'translated exonic sequence, which is also methylated in normal controls. However, using MSP primers localized to the 5'UTR, methylation of SOCS1, SOCS2 and SOCS3 is infrequent across all studies. In summary, methylation of SOCS1, SOCS2, SOCS3 and CISH is infrequent in Ph-ve MPN. Appropriate MSP primers are important for accurate estimation of the methylation frequency. The role of SHP1 methylation in the pathogenesis of MPN warrants further investigation. © 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  8. IGF-1 induces SOCS-2 but not SOCS-1 and SOCS-3 transcription in juvenile Nile tilapia (Oreochromis niloticus).

    Science.gov (United States)

    Liu, Cai-Zhi; Luo, Yuan; Limbu, Samwel Mchele; Chen, Li-Qiao; Du, Zhen-Yu

    2018-05-20

    Insulin-like growth factor-1 (IGF-1) plays a crucial role in regulating growth in vertebrates whereas suppressors of cytokine signaling (SOCS) act as feedback inhibitors of the GH/IGF-1 axis. Although SOCS-2 binds the IGF-1 receptor and inhibits IGF-1-induced STAT3 activation, presently there is no clear evidence as to whether IGF-1 could induce SOCS gene expression. The current study aimed to determine whether IGF-1 could induce the transcription of SOCS in juvenile Nile tilapia ( Oreochromis niloticus ). We show that there is a common positive relationship between the mRNA expression of IGF-I and SOCS-2 under different nutritional statuses and stimulants, but not the mRNA expression of SOCS-1 and SOCS-3 Furthermore, rhIGF-1 treatment and transcriptional activity assay confirmed the hypothesis that IGF-1 could induce SOCS-2 expression, whereas it had no effect or even decreased the expression of SOCS-1 and SOCS-3 Overall, we obtained evidence that the transcription of SOCS-2, but not SOCS-1 or SOCS-3, could be induced by IGF signaling, suggesting that SOCS-2 serves as a feedback suppressor of the IGF-1 axis in juvenile Nile tilapia. © 2018. Published by The Company of Biologists Ltd.

  9. An Online SOC and SOH Estimation Model for Lithium-Ion Batteries

    Directory of Open Access Journals (Sweden)

    Shyh-Chin Huang

    2017-04-01

    Full Text Available The monitoring and prognosis of cell degradation in lithium-ion (Li-ion batteries are essential for assuring the reliability and safety of electric and hybrid vehicles. This paper aims to develop a reliable and accurate model for online, simultaneous state-of-charge (SOC and state-of-health (SOH estimations of Li-ion batteries. Through the analysis of battery cycle-life test data, the instantaneous discharging voltage (V and its unit time voltage drop, V′, are proposed as the model parameters for the SOC equation. The SOH equation is found to have a linear relationship with 1/V′ times the modification factor, which is a function of SOC. Four batteries are tested in the laboratory, and the data are regressed for the model coefficients. The results show that the model built upon the data from one single cell is able to estimate the SOC and SOH of the three other cells within a 5% error bound. The derived model is also proven to be robust. A random sampling test to simulate the online real-time SOC and SOH estimation proves that this model is accurate and can be potentially used in an electric vehicle battery management system (BMS.

  10. Clock generators for SOC processors circuits and architectures

    CERN Document Server

    Fahim, Amr

    2004-01-01

    This book explores the design of fully-integrated frequency synthesizers suitable for system-on-a-chip (SOC) processors. The text takes a more global design perspective in jointly examining the design space at the circuit level as well as at the architectural level. The comprehensive coverage includes summary chapters on circuit theory as well as feedback control theory relevant to the operation of phase locked loops (PLLs). On the circuit level, the discussion includes low-voltage analog design in deep submicron digital CMOS processes, effects of supply noise, substrate noise, as well device noise. On the architectural level, the discussion includes PLL analysis using continuous-time as well as discrete-time models, linear and nonlinear effects of PLL performance, and detailed analysis of locking behavior. The book provides numerous real world applications, as well as practical rules-of-thumb for modern designers to use at the system, architectural, as well as the circuit level.

  11. Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells

    International Nuclear Information System (INIS)

    Lesinski, Gregory B; Zimmerer, Jason M; Kreiner, Melanie; Trefry, John; Bill, Matthew A; Young, Gregory S; Becknell, Brian; Carson, William E III

    2010-01-01

    Endogenously produced interferons can regulate the growth of melanoma cells and are administered exogenously as therapeutic agents to patients with advanced cancer. We investigated the role of negative regulators of interferon signaling known as suppressors of cytokine signaling (SOCS) in mediating interferon-resistance in human melanoma cells. Basal and interferon-alpha (IFN-α) or interferon-gamma (IFN-γ)-induced expression of SOCS1 and SOCS3 proteins was evaluated by immunoblot analysis in a panel of n = 10 metastatic human melanoma cell lines, in human embryonic melanocytes (HEM), and radial or vertical growth phase melanoma cells. Over-expression of SOCS1 and SOCS3 proteins in melanoma cells was achieved using the PINCO retroviral vector, while siRNA were used to inhibit SOCS1 and SOCS3 expression. Tyr 701 -phosphorylated STAT1 (P-STAT1) was measured by intracellular flow cytometry and IFN-stimulated gene expression was measured by Real Time PCR. SOCS1 and SOCS3 proteins were expressed at basal levels in melanocytes and in all melanoma cell lines examined. Expression of the SOCS1 and SOCS3 proteins was also enhanced following stimulation of a subset of cell lines with IFN-α or IFN-γ. Over-expression of SOCS proteins in melanoma cell lines led to significant inhibition of Tyr 701 -phosphorylated STAT1 (P-STAT1) and gene expression following stimulation with IFN-α (IFIT2, OAS-1, ISG-15) or IFN-γ (IRF1). Conversely, siRNA inhibition of SOCS1 and SOCS3 expression in melanoma cells enhanced their responsiveness to interferon stimulation. These data demonstrate that SOCS proteins are expressed in human melanoma cell lines and their modulation can influence the responsiveness of melanoma cells to IFN-α and IFN-γ

  12. Characterization of System on a Chip (SoC) Single Event Upset (SEU) Responses Using SEU Data, Classical Reliability Models, and Space Environment Data

    Science.gov (United States)

    Berg, Melanie; Label, Kenneth; Campola, Michael; Xapsos, Michael

    2017-01-01

    We propose a method for the application of single event upset (SEU) data towards the analysis of complex systems using transformed reliability models (from the time domain to the particle fluence domain) and space environment data.

  13. Correct-by-construction approaches for SoC design

    CERN Document Server

    Sinha, Roopak; Basu, Samik

    2013-01-01

    This book describes an approach for designing Systems-on-Chip such that the system meets precise mathematical requirements. The methodologies presented enable embedded systems designers to reuse intellectual property (IP) blocks from existing designs in an efficient, reliable manner, automatically generating correct SoCs from multiple, possibly mismatching, components.

  14. Correlation between the model accuracy and model-based SOC estimation

    International Nuclear Information System (INIS)

    Wang, Qianqian; Wang, Jiao; Zhao, Pengju; Kang, Jianqiang; Yan, Few; Du, Changqing

    2017-01-01

    State-of-charge (SOC) estimation is a core technology for battery management systems. Considerable progress has been achieved in the study of SOC estimation algorithms, especially the algorithm on the basis of Kalman filter to meet the increasing demand of model-based battery management systems. The Kalman filter weakens the influence of white noise and initial error during SOC estimation but cannot eliminate the existing error of the battery model itself. As such, the accuracy of SOC estimation is directly related to the accuracy of the battery model. Thus far, the quantitative relationship between model accuracy and model-based SOC estimation remains unknown. This study summarizes three equivalent circuit lithium-ion battery models, namely, Thevenin, PNGV, and DP models. The model parameters are identified through hybrid pulse power characterization test. The three models are evaluated, and SOC estimation conducted by EKF-Ah method under three operating conditions are quantitatively studied. The regression and correlation of the standard deviation and normalized RMSE are studied and compared between the model error and the SOC estimation error. These parameters exhibit a strong linear relationship. Results indicate that the model accuracy affects the SOC estimation accuracy mainly in two ways: dispersion of the frequency distribution of the error and the overall level of the error. On the basis of the relationship between model error and SOC estimation error, our study provides a strategy for selecting a suitable cell model to meet the requirements of SOC precision using Kalman filter.

  15. SOCS proteins in development and disease

    Science.gov (United States)

    Trengove, Monique C; Ward, Alister C

    2013-01-01

    Cytokine and growth factor signaling mediates essential roles in the differentiation, proliferation, survival and function of a number of cell lineages. This is achieved via specific receptors located on the surface of target cells, with ligand binding activating key intracellular signal transduction cascades to mediate the requisite cellular outcome. Effective resolution of receptor signaling is also essential, with excessive signaling having the potential for pathological consequences. The Suppressor of cytokine signaling (SOCS) family of proteins represent one important mechanism to extinguish cytokine and growth factor receptor signaling. There are 8 SOCS proteins in mammals; SOCS1-7 and the alternatively named Cytokine-inducible SH2-containing protein (CISH). SOCS1-3 and CISH are predominantly associated with the regulation of cytokine receptor signaling, while SOCS4-7 are more commonly involved in the control of Receptor tyrosine kinase (RTK) signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. As a consequence of their regulatory properties, SOCS proteins have important functions in development and homeostasis, with increasing recognition of their role in disease, particularly their tumor suppressor and anti-inflammatory functions. This review provides a synthesis of our current understanding of the SOCS family, with an emphasis on their immune and hematopoietic roles. PMID:23885323

  16. Applying transport-distance specific SOC distribution to calibrate soil erosion model WaTEM

    Science.gov (United States)

    Hu, Yaxian; Heckrath, Goswin J.; Kuhn, Nikolaus J.

    2016-04-01

    Slope-scale soil erosion, transport and deposition fundamentally decide the spatial redistribution of eroded sediments in terrestrial and aquatic systems, which further affect the burial and decomposition of eroded SOC. However, comparisons of SOC contents between upper eroding slope and lower depositional site cannot fully reflect the movement of eroded SOC in-transit along hillslopes. The actual transport distance of eroded SOC is decided by its settling velocity. So far, the settling velocity distribution of eroded SOC is mostly calculated from mineral particle specific SOC distribution. Yet, soil is mostly eroded in form of aggregates, and the movement of aggregates differs significantly from individual mineral particles. This urges a SOC erodibility parameter based on actual transport distance distribution of eroded fractions to better calibrate soil erosion models. Previous field investigation on a freshly seeded cropland in Denmark has shown immediate deposition of fast settling soil fractions and the associated SOC at footslopes, followed by a fining trend at the slope tail. To further quantify the long-term effects of topography on erosional redistribution of eroded SOC, the actual transport-distance specific SOC distribution observed on the field was applied to a soil erosion model WaTEM (based on USLE). After integrating with local DEM, our calibrated model succeeded in locating the hotspots of enrichment/depletion of eroded SOC on different topographic positions, much better corresponding to the real-world field observation. By extrapolating into repeated erosion events, our projected results on the spatial distribution of eroded SOC are also adequately consistent with the SOC properties in the consecutive sample profiles along the slope.

  17. Online cell SOC estimation of Li-ion battery packs using a dual time-scale Kalman filtering for EV applications

    International Nuclear Information System (INIS)

    Dai, Haifeng; Wei, Xuezhe; Sun, Zechang; Wang, Jiayuan; Gu, Weijun

    2012-01-01

    Highlights: ► We use an equivalent circuit model to describe the characteristics of battery. ► A dual time-scale estimator is used to calculate pack average SOC and cell SOC. ► The estimator is based on the dynamic descriptions and extended Kalman filter. ► Three different test cases are designed to validate the proposed method. ► Test results indicate a good performance of the method for EV applications. -- Abstract: For the vehicular operation, due to the voltage and power/energy requirements, the battery systems are usually composed of up to hundreds of cells connected in series or parallel. To accommodate the operation conditions, the battery management system (BMS) should estimate State of Charge (SOC) to facilitate safe and efficient utilization of the battery. The performance difference among the cells makes a pure pack SOC estimation hardly provide sufficient information, which at last affects the computation of available energy and power and the safety of the battery system. So for a reliable and accurate management, the BMS should “know” the SOC of each individual cell. Several possible solutions on this issue have been reported in the recent years. This paper studies a method to determine online all individual cell SOCs of a series-connected battery pack. This method, with an equivalent circuit based “averaged cell” model, estimates the battery pack’s average SOC first, and then incorporates the performance divergences between the “averaged cell” and each individual cell to generate the SOC estimations for all cells. This method is developed based on extended Kalman filter (EKF), and to reduce the computation cost, a dual time-scale implementation is designed. The method is validated using results obtained from the measurements of a Li-ion battery pack under three different tests, and analysis indicates the good performance of the algorithm.

  18. SPAD array based TOF SoC design for unmanned vehicle

    Science.gov (United States)

    Pan, An; Xu, Yuan; Xie, Gang; Huang, Zhiyu; Zheng, Yanghao; Shi, Weiwei

    2018-03-01

    As for the requirement of unmanned-vehicle mobile Lidar system, this paper presents a SoC design based on pulsed TOF depth image sensor. This SoC has a detection range of 300m and detecting resolution of 1.5cm. Pixels are made of SPAD. Meanwhile, SoC adopts a structure of multi-pixel sharing TDC, which significantly reduces chip area and improve the fill factor of light-sensing surface area. SoC integrates a TCSPC module to achieve the functionality of receiving each photon, measuring photon flight time and processing depth information in one chip. The SOC is designed in the SMIC 0.13μm CIS CMOS technology

  19. A microprocessor from AVR to embedded SoC

    International Nuclear Information System (INIS)

    Jeong, Geum Seoh

    2005-01-01

    This book was divided into two parts. The first part consists of ten chapter, which are basic knowledge, code vision AVR compiler, analysis on code vision, introduction and characteristic of AVR, I/O ports, interrupt and timer/counter, LCD, serial communication, analog comparator and stepping Motor and digital control of DC Motor. In the second part, it introduces Embedded Soc including application field, its characteristic, general description, functional description, designs with Quartus II.

  20. Impact of vegetation types on soil organic carbon stocks SOC-S in Mediterranean natural areas

    Science.gov (United States)

    Parras-Alcántara, Luis; Lozano-García, Beatriz; Cantudo-Pérez, Marta

    2015-04-01

    Soils play a key role in the carbon geochemical cycle because they can either emit large quantities of CO2 or on the contrary they can act as a store for carbon. Agriculture and forestry are the only activities that can achieve this effect through photosynthesis and the carbon incorporation into carbohydrates (Parras-Alcántara et al., 2013). The Mediterranean evergreen oak Woodland (MEOW - dehesa) is a type of pasture with scattered evergreen and deciduous oak stands in which cereals are often grown under the tree cover. It is a system dedicated to the combined production of Iberian swine, sheep, fuel wood, coal and cork as well as to hunting. These semi-natural areas still preserve some of the primitive vegetation of the Mediterranean oak forests. The dehesa is a pasture where the herbaceous layer is comprised of either cultivated cereals such as oat, barley and wheat or native vegetation dominated by annual species, which are used as grazing resources. These Iberian open woodland rangelands (dehesas) have been studied from different points of view: hydrologically, with respect to soil organic matter content, as well as in relation to gully erosion, topographical thresholds, soil erosion and runoff production, soil degradation and management practices…etc, among others. The soil organic carbon stock capacity depends not only on abiotic factors such as the mineralogical composition and the climate, but also on soil use and management (Parras et al., 2014 and 2015). In Spanish soils, climate, use and management strongly affect the carbon variability, mainly in soils in dry Mediterranean climates characterized by low organic carbon content, weak structure and readily degradable soils. Hontoria et al. (2004) emphasized that the climate and soil use are two factors that greatly influence carbon content in the Mediterranean climate. This research sought to analyze the SOC stock (SOCS) variability in MEOW - dehesa with cereals, olive grove and Mediterranean oak forest

  1. A step toward 'plug and play' robotics with SoC technology

    DEFF Research Database (Denmark)

    Sørensen, Anders Stengaard; Falsig, Simon; Ugilt, Rolf

    p, li { white-space: pre-wrap; } This article describe our progress toward simplifying and streamlining the low level systems integration of experimental robots, combining a System on Chip (SoC) approach with conventional modular approaches. The combined approach has increased flexibility, improved...... the embedded integration, and decreased the complexity of programming, compared to conventional modular approaches. We show the impact of the SoC approach in a simple demonstration and teaching model of a walking robot....

  2. Respiratory Syncytial Virus Nonstructural Proteins Upregulate SOCS1 and SOCS3 in the Different Manner from Endogenous IFN Signaling

    Directory of Open Access Journals (Sweden)

    Junwen Zheng

    2015-01-01

    Full Text Available Respiratory syncytial virus (RSV infection upregulates genes of the suppressor of cytokine signaling (SOCS family, which utilize a feedback loop to inhibit type I interferon dependent antiviral signaling pathway. Here, we reconstituted RSV nonstructural (NS protein expression plasmids (pNS1, pNS2, and pNS1/2 and tested whether NS1 or NS2 would trigger SOCS1 and SOCS3 protein expression. These NS proteins inhibited interferon- (IFN- α signaling through a mechanism involving the induction of SOCS1 and SOCS3, which appeared to be different from autocrine IFN dependent. NS1 induced both SOCS1 and SOCS3 upregulation, while NS2 only induced SOCS1 expression. The induced expression of SOCS1 and SOCS3 preceded endogenous IFN-signaling activation and inhibited the IFN-inducible antiviral response as well as chemokine induction. Treatments with INF-α and NS proteins both induced SOCS1 expression; however, they had opposing effects on IFN-α-dependent antiviral gene expression. Our results indicate that NS1 and NS2, which induce the expression of SOCS1 or SOCS3, might represent an independent pathway of stimulating endogenous IFN signaling.

  3. Comparison Study on the Battery SoC Estimation with EKF and UKF Algorithms

    Directory of Open Access Journals (Sweden)

    Hongwen He

    2013-09-01

    Full Text Available The battery state of charge (SoC, whose estimation is one of the basic functions of battery management system (BMS, is a vital input parameter in the energy management and power distribution control of electric vehicles (EVs. In this paper, two methods based on an extended Kalman filter (EKF and unscented Kalman filter (UKF, respectively, are proposed to estimate the SoC of a lithium-ion battery used in EVs. The lithium-ion battery is modeled with the Thevenin model and the model parameters are identified based on experimental data and validated with the Beijing Driving Cycle. Then space equations used for SoC estimation are established. The SoC estimation results with EKF and UKF are compared in aspects of accuracy and convergence. It is concluded that the two algorithms both perform well, while the UKF algorithm is much better with a faster convergence ability and a higher accuracy.

  4. System analysis and design

    International Nuclear Information System (INIS)

    Son, Seung Hui

    2004-02-01

    This book deals with information technology and business process, information system architecture, methods of system development, plan on system development like problem analysis and feasibility analysis, cases for system development, comprehension of analysis of users demands, analysis of users demands using traditional analysis, users demands analysis using integrated information system architecture, system design using integrated information system architecture, system implementation, and system maintenance.

  5. Robustness of SOC Estimation Algorithms for EV Lithium-Ion Batteries against Modeling Errors and Measurement Noise

    Directory of Open Access Journals (Sweden)

    Xue Li

    2015-01-01

    Full Text Available State of charge (SOC is one of the most important parameters in battery management system (BMS. There are numerous algorithms for SOC estimation, mostly of model-based observer/filter types such as Kalman filters, closed-loop observers, and robust observers. Modeling errors and measurement noises have critical impact on accuracy of SOC estimation in these algorithms. This paper is a comparative study of robustness of SOC estimation algorithms against modeling errors and measurement noises. By using a typical battery platform for vehicle applications with sensor noise and battery aging characterization, three popular and representative SOC estimation methods (extended Kalman filter, PI-controlled observer, and H∞ observer are compared on such robustness. The simulation and experimental results demonstrate that deterioration of SOC estimation accuracy under modeling errors resulted from aging and larger measurement noise, which is quantitatively characterized. The findings of this paper provide useful information on the following aspects: (1 how SOC estimation accuracy depends on modeling reliability and voltage measurement accuracy; (2 pros and cons of typical SOC estimators in their robustness and reliability; (3 guidelines for requirements on battery system identification and sensor selections.

  6. Suppressor of cytokine signaling 4 (SOCS4 protects against severe cytokine storm and enhances viral clearance during influenza infection.

    Directory of Open Access Journals (Sweden)

    Lukasz Kedzierski

    2014-05-01

    Full Text Available Suppressor of cytokine signaling (SOCS proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with a pathogenic H1N1 influenza virus (PR8 and are hypersusceptible to infection with the less virulent H3N2 (X31 strain. In SOCS4-deficient animals, this led to substantially greater weight loss, dysregulated pro-inflammatory cytokine and chemokine production in the lungs and delayed viral clearance. This was associated with impaired trafficking of influenza-specific CD8 T cells to the site of infection and linked to defects in T cell receptor activation. These results demonstrate that SOCS4 is a critical regulator of anti-viral immunity.

  7. A Bayesian Belief Network framework to predict SOC stock change: the Veneto region (Italy) case study

    Science.gov (United States)

    Dal Ferro, Nicola; Quinn, Claire Helen; Morari, Francesco

    2017-04-01

    A key challenge for soil scientists is predicting agricultural management scenarios that combine crop productions with high standards of environmental quality. In this context, reversing the soil organic carbon (SOC) decline in croplands is required for maintaining soil fertility and contributing to mitigate GHGs emissions. Bayesian belief networks (BBN) are probabilistic models able to accommodate uncertainty and variability in the predictions of the impacts of management and environmental changes. By linking multiple qualitative and quantitative variables in a cause-and-effect relationships, BBNs can be used as a decision support system at different spatial scales to find best management strategies in the agroecosystems. In this work we built a BBN to model SOC dynamics (0-30 cm layer) in the low-lying plain of Veneto region, north-eastern Italy, and define best practices leading to SOC accumulation and GHGs (CO2-equivalent) emissions reduction. Regional pedo-climatic, land use and management information were combined with experimental and modelled data on soil C dynamics as natural and anthropic key drivers affecting SOC stock change. Moreover, utility nodes were introduced to determine optimal decisions for mitigating GHGs emissions from croplands considering also three different IPCC climate scenarios. The network was finally validated with real field data in terms of SOC stock change. Results showed that the BBN was able to model real SOC stock changes, since validation slightly overestimated SOC reduction (+5%) at the expenses of its accumulation. At regional level, probability distributions showed 50% of SOC loss, while only 17% of accumulation. However, the greatest losses (34%) were associated with low reduction rates (100-500 kg C ha-1 y-1), followed by 33% of stabilized conditions (-100 < SOC < 100 kg ha-1 y-1). Land use management (especially tillage operations and soil cover) played a primary role to affect SOC stock change, while climate conditions

  8. NEW EPICS/RTEMS IOC BASED ON ALTERA SOC AT JEFFERSON LAB

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Jianxun [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Seaton, Chad [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Allison, Trent L. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Bevins, Brian S. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Cuffe, Anthony W. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2018-02-01

    A new EPICS/RTEMS IOC based on the Altera System-on-Chip (SoC) FPGA is being designed at Jefferson Lab. The Altera SoC FPGA integrates a dual ARM Cortex-A9 Hard Processor System (HPS) consisting of processor, peripherals and memory interfaces tied seamlessly with the FPGA fabric using a high-bandwidth interconnect backbone. The embedded Altera SoC IOC has features of remote network boot via U-Boot from SD card or QSPI Flash, 1Gig Ethernet, 1GB DDR3 SDRAM on HPS, UART serial ports, and ISA bus interface. RTEMS for the ARM processor BSP were built with CEXP shell, which will dynamically load the EPICS applications at runtime. U-Boot is the primary bootloader to remotely load the kernel image into local memory from a DHCP/TFTP server over Ethernet, and automatically run RTEMS and EPICS. The first design of the SoC IOC will be compatible with Jefferson Lab’s current PC104 IOCs, which have been running in CEBAF 10 years. The next design would be mounting in a chassis and connected to a daughter card via standard HSMC connectors. This standard SoC IOC will become the next generation of low-level IOC for the accelerator controls at Jefferson Lab.

  9. Effects of SOC-dependent electrolyte viscosity on performance of vanadium redox flow batteries

    International Nuclear Information System (INIS)

    Xu, Q.; Zhao, T.S.; Zhang, C.

    2014-01-01

    Highlights: • The correlations of electrolyte viscosity and SOC are obtained. • Effect of SOC-dependent electrolyte viscosity is considered in this model. • This model enables a more realistic simulation of variable distributions. • It provides accurate estimations of pumping work and system efficiency. - Abstract: The viscosity of the electrolyte in vanadium redox flow batteries (VRFBs) varies during charge and discharge as the concentrations of acid and vanadium ions in the electrolyte continuously change with the state of charge (SOC). In previous VRFB models, however, the electrolyte has been treated as a constant-viscosity solution. In this work, a mass-transport and electrochemical model taking account of the effect of SOC-dependent electrolyte viscosity is developed. The comparison between the present model and the model with the constant-viscosity simplification indicates that the consideration of the SOC-dependent electrolyte viscosity enables (i) a more realistic simulation of the distributions of overpotential and current density in the electrodes, and (ii) more accurate estimations of pumping work and the system efficiency of VRFBs

  10. Soft error evaluation and vulnerability analysis in Xilinx Zynq-7010 system-on chip

    Energy Technology Data Exchange (ETDEWEB)

    Du, Xuecheng; He, Chaohui; Liu, Shuhuan, E-mail: liushuhuan@mail.xjtu.edu.cn; Zhang, Yao; Li, Yonghong; Xiong, Ceng; Tan, Pengkang

    2016-09-21

    Radiation-induced soft errors are an increasingly important threat to the reliability of modern electronic systems. In order to evaluate system-on chip's reliability and soft error, the fault tree analysis method was used in this work. The system fault tree was constructed based on Xilinx Zynq-7010 All Programmable SoC. Moreover, the soft error rates of different components in Zynq-7010 SoC were tested by americium-241 alpha radiation source. Furthermore, some parameters that used to evaluate the system's reliability and safety were calculated using Isograph Reliability Workbench 11.0, such as failure rate, unavailability and mean time to failure (MTTF). According to fault tree analysis for system-on chip, the critical blocks and system reliability were evaluated through the qualitative and quantitative analysis.

  11. Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing

    Science.gov (United States)

    Feng, Yi; Sanders, Andrew J.; Ruge, Fiona; Morris, Ceri-Ann; Harding, Keith G.; Jiang, Wen G.

    2016-01-01

    Cytokines play important roles in the wound healing process through various signalling pathways. The JAK-STAT pathway is utilised by most cytokines for signal transduction and is regulated by a variety of molecules, including suppressor of cytokine signalling (SOCS) proteins. SOCS are associated with inflammatory diseases and have an impact on cytokines, growth factors and key cell types involved in the wound-healing process. SOCS, a negative regulator of cytokine signalling, may hold the potential to regulate cytokine-induced signalling in the chronic wound-healing process. Wound edge tissues were collected from chronic venous leg ulcer patients and classified as non-healing and healing wounds. The expression pattern of seven SOCSs members, at the transcript and protein level, were examined in these tissues using qPCR and immunohistochemistry. Significantly higher levels of SOCS3 (P=0.0284) and SOCS4 (P=0.0376) in non-healing chronic wounds compared to the healing/healed chronic wounds were observed at the transcript level. Relocalisation of SOCS3 protein in the non-healing wound environment was evident in the investigated chronic biopsies. Thus, the results show that the expression of SOCS transcript indicated that SOCS members may act as a prognostic biomarker of chronic wounds. PMID:27635428

  12. Modeling of SOC-700 Hyperspectral Imagery with the CAMEO-SIM Code

    Science.gov (United States)

    2007-10-26

    Yannick, 2001, “SOC-700 and HS-Analysis 2 User’s Manual”, Surface Optics, San Diego [2] Cohen, Michael F. and Wallace, John R., 1993, “ Radiosity ...and Realistic Image Synthesis”, Academic Press, San Francisco [3] Sillion, Francois X. and Puech, Claude, 1994, “ Radiosity and Global Illumination

  13. SOCS3 promoter hypermethylation is a favorable prognosticator and a novel indicator for G-CIMP-positive GBM patients.

    Science.gov (United States)

    Feng, Ying; Wang, Zheng; Bao, Zhaoshi; Yan, Wei; You, Gan; Wang, Yinyan; Hu, Huimin; Zhang, Wei; Zhang, Quangeng; Jiang, Tao

    2014-01-01

    Hypermethylation of the suppressor of cytokine signaling 3(SOCS3) promoter has been reported to predict a poor prognosis in several cancers including glioblastoma multiforme (GBM). We explored the function of SOCS3 promoter hypermethylation in GBM cohorts, including analysis of the CpG island methylator phenotype (CIMP), when a large number of gene loci are simultaneously hypermethylated. A whole genome promoter methylation profile was performed in a cohort of 33 GBM samples, with 13 long-term survivors (LTS; overall survival ≥ 18 months) and 20 short-term survivors (STS; overall survival ≤ 9 months). The SOCS3 promoter methylation status was compared between the two groups. In addition, we investigated the relationship of SOCS3 promoter methylation and G-CIMP status. Interestingly, in our present study, we found that SOCS3 promoter methylation was statistically significantly higher in the 13 LTS than that in the 20 STS. Furthermore, high SOCS3 promoter methylation detected via pyro-sequencing predicted a better prognosis in an independent cohort containing 62 GBM patients. This correlation was validated by the dataset from the Cancer Genome Atlas(TCGA) and the Chinese Cancer Genome Atlas(CGGA). In addition, we found that hypermethylation of the SOCS3 promoter was tightly associated with the G-CIMP-positive GBM patients. Using a total of 359 clinical samples, we demonstrate that SOCS3 promoter hypermethylation status has a favorable prognostic value in GBM patients because of whole genome methylation status. Particularly, the hypermethylation of the SOCS3 promoter indicates positive G-CIMP status.

  14. SOCS3 promoter hypermethylation is a favorable prognosticator and a novel indicator for G-CIMP-positive GBM patients.

    Directory of Open Access Journals (Sweden)

    Ying Feng

    Full Text Available Hypermethylation of the suppressor of cytokine signaling 3(SOCS3 promoter has been reported to predict a poor prognosis in several cancers including glioblastoma multiforme (GBM. We explored the function of SOCS3 promoter hypermethylation in GBM cohorts, including analysis of the CpG island methylator phenotype (CIMP, when a large number of gene loci are simultaneously hypermethylated.A whole genome promoter methylation profile was performed in a cohort of 33 GBM samples, with 13 long-term survivors (LTS; overall survival ≥ 18 months and 20 short-term survivors (STS; overall survival ≤ 9 months. The SOCS3 promoter methylation status was compared between the two groups. In addition, we investigated the relationship of SOCS3 promoter methylation and G-CIMP status.Interestingly, in our present study, we found that SOCS3 promoter methylation was statistically significantly higher in the 13 LTS than that in the 20 STS. Furthermore, high SOCS3 promoter methylation detected via pyro-sequencing predicted a better prognosis in an independent cohort containing 62 GBM patients. This correlation was validated by the dataset from the Cancer Genome Atlas(TCGA and the Chinese Cancer Genome Atlas(CGGA. In addition, we found that hypermethylation of the SOCS3 promoter was tightly associated with the G-CIMP-positive GBM patients.Using a total of 359 clinical samples, we demonstrate that SOCS3 promoter hypermethylation status has a favorable prognostic value in GBM patients because of whole genome methylation status. Particularly, the hypermethylation of the SOCS3 promoter indicates positive G-CIMP status.

  15. SOCS2 and SOCS3 expression in ulcerative colitis and their correlation with inflammatory response and immune response

    Directory of Open Access Journals (Sweden)

    Le Huang1

    2017-05-01

    Full Text Available Objective: To study the correlation of SOCS2 and SOCS3 expression in ulcerative colitis tissue with inflammatory response and immune response. Methods: Ulcerative colitis lesions and normal mucosa from colonoscopic biopsy in Central Hospital of Zibo Mining Refco Group Ltd between May 2014 and July 2016 were selected and enrolled in UC group and control group respectively. RNA was extracted to determine mRNA expression of SOCS2 and SOCS3 as well as inflammatory response JAKs/STATs pathway molecules; protein was extracted to determine the contents of immune response cytokines. Results: SOCS2 mRNA expression in intestinal mucosa of UC group was not significantly different from that of control group, and SOCS3 mRNA expression was significantly lower than that of control group; JAK1, JAK2, JAK3, STAT1, STAT3 and STAT5 mRNA expression as well as IFN-γ and IL-17 protein contents in intestinal mucosa of UC group were significantly higher than those of control group while IL-4 and IL-10 protein contents were significantly lower than those of control group; JAK1, JAK2, JAK3, STAT1, STAT3 and STAT5 mRNA expression as well as IFN-γ and IL-17 protein contents in UC group of intestinal mucosa with low SOCS3 expression were significantly higher than those of intestinal mucosa with high SOCS3 expression while IL-4 and IL-10 protein contents were significantly lower than those of intestinal mucosa with high SOCS3 expression. Conclusion: Low expression of SOCS3 in ulcerative colitis can aggravate the inflammatory reaction and cause the imbalance of Th1/Th2 and Th17/Treg immune response.

  16. Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1.

    Science.gov (United States)

    Dobie, Ross; Ahmed, Syed F; Staines, Katherine A; Pass, Chloe; Jasim, Seema; MacRae, Vicky E; Farquharson, Colin

    2015-11-01

    Growth hormone (GH) signaling is essential for postnatal linear bone growth, but the relative importance of GHs actions on the liver and/or growth plate cartilage remains unclear. The importance of liver derived insulin like-growth factor-1 (IGF-1) for endochondral growth has recently been challenged. Here, we investigate linear growth in Suppressor of Cytokine Signaling-2 (SOCS2) knockout mice, which have enhanced growth despite normal systemic GH/IGF-1 levels. Wild-type embryonic ex vivo metatarsals failed to exhibit increased linear growth in response to GH, but displayed increased Socs2 transcript levels (P growth over a 12 day period. Despite this increase, IGF-1 transcript and protein levels were not increased in response to GH. In accordance with these data, IGF-1 levels were unchanged in GH-challenged postnatal Socs2(-/-) conditioned medium despite metatarsals showing enhanced linear growth. Growth-plate Igf1 mRNA levels were not elevated in juvenile Socs2(-/-) mice. GH did however elevate IGF-binding protein 3 levels in conditioned medium from GH challenged metatarsals and this was more apparent in Socs2(-/-) metatarsals. GH did not enhance the growth of Socs2(-/-) metatarsals when the IGF receptor was inhibited, suggesting that IGF receptor mediated mechanisms are required. IGF-2 may be responsible as IGF-2 promoted metatarsal growth and Igf2 expression was elevated in Socs2(-/-) (but not WT) metatarsals in response to GH. These studies emphasise the critical importance of SOCS2 in regulating GHs ability to promote bone growth. Also, GH appears to act directly on the metatarsals of Socs2(-/-) mice, promoting growth via a mechanism that is independent of IGF-1. © 2014 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.

  17. Effects of different soil types in natural Mediterranean areas on soil organic carbon (SOC)

    Science.gov (United States)

    Requejo Silva, Ana; Lozano García, Beatriz; Parras Alcántara, Luis

    2017-04-01

    statement, the main goal of this work consists in establishing the vertical distribution in the profile of SOC and N concentrations and to quantify the SOC and N stocks affected by different soil types in a natural Mediterranean area, under the same land use (agroforestry system) and management (conventional tillage). This will allow to evaluate the soil quality. It was verified that SOC concentrations significantly decreased with depth in the majority of soil profiles for all soil groups under consideration. Leptosols are characterized by the highest concentration of soil organic carbon in the subsurface horizons as opposed to Cambisols which are defined by the lowest SOC concentration in depth. The SOC stock determined in the studied soil groups are 110. Mg. ha-1 for Fluvisols and 78.35 Mg.ha-1 for Regosols that can be caused by soil thickness. According to McLauchlan (2006), it cannot be found a strong relationship between clay content and organic carbon in the soil groups under study. REFERENCES IPPC: Climate Change 2007: the physical science basis, Cambridge University Press: Cambridge/New York, NY, 2007. IUSS Working Group WRB, 2006. World Reference base for soil resources 2006. World Soil Resources Report N° 103. FAO, Rome. Khaledian, Y., Kiani, F., Ebrahimi, S., Brevik, E.C., Aitkenhead-Peterson, J., 2016. Assessment and monitoring of soil degradation during land use change using multivariate analysis. Land Degrad. Dev. Doi: http:// dx.doi.org/10.1002/ldr.2541. Lozano-García, B., Parras-Alcántara, L., Cantudo-Pérez, M., 2016. Land use change effects on stratification and storage of soil carbon and nitrogen: Application to a Mediterranean nature reserve. Agriculture, Ecosystems and Environment, 231, 105-113. McLauchlan, K.K., 2006. Effect of soil texture on soil carbon and nitrogen dynamic after cessation of agriculture. Geoderma 136, 289-299. Parras-Alcántara, L., Martín-Carrillo, M. and Lozano-García, B. Impacts of land use change in soil carbon and nitrogen

  18. A Flexible ADC Approach for Mixed-signal SoC Platforms

    NARCIS (Netherlands)

    Zanikopoulos, A.; Harpe, P.J.A.; Hegt, J.A.; Roermund, van A.H.M.

    2005-01-01

    Time-to-market pressure and increased design complexity created what is called a "design gap" [1] in the design of systems-on-chip (SoC). As a solution to that problem the Platform-Based Design (PBD), based on the design-reuse methodology, has been proposed [2], and successfully applied to digital

  19. Increasing SoC Dependability via Known Good Tile NoC Testing

    NARCIS (Netherlands)

    Kerkhoff, Hans G.; Kuiken, O.J.; Zhang, X.

    2008-01-01

    Advanced CMOS technology possibilities, power, communication and flexibility issues as well as the design gap are directing System-on-Chip (SoC) platforms towards Network-on-Chip (NoC) interconnected identical processing tiles (PT) such as the Montium processor [1]. It is broadly acknowledged that

  20. Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis.

    Directory of Open Access Journals (Sweden)

    Marc Amoyel

    2016-01-01

    Full Text Available The Drosophila testis is a well-established system for studying stem cell self-renewal and competition. In this tissue, the niche supports two stem cell populations, germ line stem cells (GSCs, which give rise to sperm, and somatic stem cells called cyst stem cells (CySCs, which support GSCs and their descendants. It has been established that CySCs compete with each other and with GSCs for niche access, and mutations have been identified that confer increased competitiveness to CySCs, resulting in the mutant stem cell and its descendants outcompeting wild type resident stem cells. Socs36E, which encodes a negative feedback inhibitor of the JAK/STAT pathway, was the first identified regulator of niche competition. The competitive behavior of Socs36E mutant CySCs was attributed to increased JAK/STAT signaling. Here we show that competitive behavior of Socs36E mutant CySCs is due in large part to unbridled Mitogen-Activated Protein Kinase (MAPK signaling. In Socs36E mutant clones, MAPK activity is elevated. Furthermore, we find that clonal upregulation of MAPK in CySCs leads to their outcompetition of wild type CySCs and of GSCs, recapitulating the Socs36E mutant phenotype. Indeed, when MAPK activity is removed from Socs36E mutant clones, they lose their competitiveness but maintain self-renewal, presumably due to increased JAK/STAT signaling in these cells. Consistently, loss of JAK/STAT activity in Socs36E mutant clones severely impairs their self-renewal. Thus, our results enable the genetic separation of two essential processes that occur in stem cells. While some niche signals specify the intrinsic property of self-renewal, which is absolutely required in all stem cells for niche residence, additional signals control the ability of stem cells to compete with their neighbors. Socs36E is node through which these processes are linked, demonstrating that negative feedback inhibition integrates multiple aspects of stem cell behavior.

  1. Settling-velocity specific SOC distribution on hillslopes

    DEFF Research Database (Denmark)

    Hu, Yaxian; Berhe, Asmeret Asefaw; Fogel, Marilyn L.

    The net effect of soil erosion by water, as a sink or source of atmospheric CO2, is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC). The depositional position of eroded SOC is a function of the transport distances of soil fractions where the SOC...... fractions. Eroding sandy soils and sediment were sampled after a series of rainfall events along a slope on a freshly seeded cropland in Jutland, Denmark. All the soil samples were fractionated into five settling classes using a settling tube apparatus. The spatial distribution of soil settling classes...... shows a coarsening effect immediately below the eroding slope, followed by a fining trend at the slope tail. The 13C values of soil fractions were more positive at the footslope than on the slope shoulder or at the slope tail, suggesting enhanced decomposition rate of fresh SOC input at the footslope...

  2. The simple art of SoC design

    CERN Document Server

    Keating, Michael

    2011-01-01

    This book tackles head-on the challenges of digital design in the era of billion-transistor SoCs. It discusses fundamental design concepts in design and coding required to produce robust, functionally correct designs. It also provides specific techniques for measuring and minimizing complexity in RTL code. Finally, it discusses the tradeoff between RTL and high-level (C-based) design and how tools and languages must progress to address the needs of tomorrow's SoC designs.

  3. Constitutive expression of the K-domain of a Vaccinium corymbosum SOC1-like (VcSOC1-K) MADS-box gene is sufficient to promote flowering in tobacco.

    Science.gov (United States)

    Song, Guo-qing; Walworth, Aaron; Zhao, Dongyan; Hildebrandt, Britton; Leasia, Michael

    2013-11-01

    The K-domain of a blueberry-derived SOC1 -like gene promotes flowering in tobacco without negatively impacting yield, demonstrating potential for manipulation of flowering time in horticultural crops. The SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) and SOC1-likes, belonging to the MIKC(c) (type II) MADS-box gene subfamily, are major floral activators and integrators of plant flowering. Both MADS-domains and K (Keratin)-domains are highly conserved in MIKC(c)-type MADS proteins. While there are many reports on overexpression of intact MIKC(c)-type MADS-box genes, few studies have been conducted to investigate the effects of the K-domains. In this report, a 474-bp K-domain of Vaccinium SOC1-like (VcSOC1-K) was cloned from the cDNA library of the northern highbush blueberry (Vaccinium corymbosum L.). Functional analysis of the VcSOC1-K was conducted by ectopically expressing of 35S:VcSOC1-K in tobacco. Reverse transcription PCR confirmed expression of the VcSOC1-K in T0 plants. Phenotypically, T1 transgenic plants (10 T1 plants/event) flowered sooner after seeding, and were shorter with fewer leaves at the time of flowering, than nontransgenic plants; but seed pod production of transgenic plants was not significantly affected. These results demonstrate that overexpression of the K-domain of a MIKC(c)-type MADS-box gene alone is sufficient to promote early flowering and more importantly without affecting seed production.

  4. Longevity of contributions to SOC stocks from roots and aboveground plant litter below a Miscanthus plantation

    Science.gov (United States)

    Robertson, Andrew; Smith, Pete; Davies, Christian; Bottoms, Emily; McNamara, Niall

    2013-04-01

    emissions in winter and spring whereas root respiration dominates the summer and autumn fluxes. Additionally, the "No Roots or Litter" and "No Litter" treatments have significantly less Miscanthus-derived C and therefore significantly less CO2 emitted from decomposing 'new' C. Results from soil fractionation concur with these findings and also suggest that most Miscanthus-derived SOC has fairly short mean residence times within the soil. We hypothesised that the high C input treatments would stimulate large outputs but also increase soil C stocks. However, whilst CO2 efflux varies significantly between treatments, results from the first two years of the experiment do not suggest that any increase in SOC is significant. Four years of continuous monitoring, chemical and physical soil fractionation and ecosystem C cycle modelling will allow a more comprehensive analysis of the longevity of Miscanthus-derived SOC and estimation of SOC stock change with time and plant inputs.

  5. SoCRocket: A Virtual Platform for SoC Design

    Science.gov (United States)

    Fossati, Luca; Schuster, Thomas; Meyer, Rolf; Berekovic, Mladen

    2013-08-01

    Both in the commercial and in the aerospace domain, the continuous increase of transistor density on a single die is leading towards the production of more and more complex systems on a single chip, with an increasing number of components. This brought to the introduction of the System-On-Chip (SoC) architecture, that integrates on a single circuit all the elements of a full system. This strive for efficient utilization of the available silicon has triggered several paradigm shifts in system design. Similarly to what happened in the early 1990s, when VHDL and Verilog took over from schematic design, today SystemC and Transaction Level Modeling [1] are about to further raise the design abstraction level. Such descriptions have to be accurate enough to describe the entire system throughout the phases of its development, and has to provide enough flexibility to be refined iteratively up to the point where the actual device can be produced using current process technology. Besides requiring new languages and methodologies, the complexity of current and future SoCs (SCOC3 [16] and NGMP [5] are example in the space domain) forces the SoC design process to rely on pre-designed or third party components. Components obtained from different providers, and even those designed by different teams of the same company, may be heterogeneous on several aspects: design domains, interfaces, abstraction levels, granularity, etc. Therefore, component integration is required at system level. Only by applying design re-use it is possible to successfully and timely design such complex SoCs. This transition to new languages and design methods is also motivated by the implementation with software of an increasing amount of system functionalities. Hence the need for methodologies to enable early software development and which allow the analysis of the performance of the combined Hw/Sw system, as their design and configuration cannot be performed separately. Virtual Prototyping is a key

  6. SoC Estimation for Lithium-ion Batteries: Review and Future Challenges

    Directory of Open Access Journals (Sweden)

    Juan Pablo Rivera-Barrera

    2017-11-01

    Full Text Available Energy storage emerged as a top concern for the modern cities, and the choice of the lithium-ion chemistry battery technology as an effective solution for storage applications proved to be a highly efficient option. State of charge (SoC represents the available battery capacity and is one of the most important states that need to be monitored to optimize the performance and extend the lifetime of batteries. This review summarizes the methods for SoC estimation for lithium-ion batteries (LiBs. The SoC estimation methods are presented focusing on the description of the techniques and the elaboration of their weaknesses for the use in on-line battery management systems (BMS applications. SoC estimation is a challenging task hindered by considerable changes in battery characteristics over its lifetime due to aging and to the distinct nonlinear behavior. This has led scholars to propose different methods that clearly raised the challenge of establishing a relationship between the accuracy and robustness of the methods, and their low complexity to be implemented. This paper publishes an exhaustive review of the works presented during the last five years, where the tendency of the estimation techniques has been oriented toward a mixture of probabilistic techniques and some artificial intelligence.

  7. SoC Design Approach Using Convertibility Verification

    Directory of Open Access Journals (Sweden)

    Basu Samik

    2008-01-01

    Full Text Available Abstract Compositional design of systems on chip from preverified components helps to achieve shorter design cycles and time to market. However, the design process is affected by the issue of protocol mismatches, where two components fail to communicate with each other due to protocol differences. Convertibility verification, which involves the automatic generation of a converter to facilitate communication between two mismatched components, is a collection of techniques to address protocol mismatches. We present an approach to convertibility verification using module checking. We use Kripke structures to represent protocols and the temporal logic to describe desired system behavior. A tableau-based converter generation algorithm is presented which is shown to be sound and complete. We have developed a prototype implementation of the proposed algorithm and have used it to verify that it can handle many classical protocol mismatch problems along with SoC problems. The initial idea for -based convertibility verification was presented at SLA++P '07 as presented in the work by Roopak Sinha et al. 2008.

  8. EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA

    Directory of Open Access Journals (Sweden)

    V. V. Lim

    2014-01-01

    Full Text Available We observed sixty patients with allergic bronchial asthma (ABA and 54 with non-allergic bronchial asthma (NABA. Quantitative SOCS3 and SOCS5 mRNA expression was evaluated by means of real-time PCR. Eighteen healthy persons served as a control group. In patients with bronchial asthma (irrespectively of pathogenetic form, a significant increase of SOCS3 transcription factor expression was detected in peripheral blood mononuclears, as compared with control group. This increase was more pronounced in NABA group. The mRNA SOCS5 level was significantly decreased in bronchial asthma patients, as compared to control group, especially, in ABA subgroup rather than in NABA patients. Thus, an increased expression of SOCS3 mRNA in BA patients could be regarded as a protective antiinflammatory response Decrease of SOCS5 mRNA expression in patients with bronchial asthma (being more pronounced in ABA, may be indicative for a deficiency in negative feedback regulation of gene transcription in allergic bronchial asthma.

  9. Dynamics and fate of SOC in tidal marshes along a salinity gradient (Scheldt estuary, Belgium)

    Science.gov (United States)

    Van de Broek, Marijn; Temmermann, Stijn; Merckx, Roel; Wang, Zhengang; Govers, Gerard

    2016-04-01

    Coastal ecosystems have been attributed the potential to store large amounts of organic carbon (OC), often referred to as blue carbon, of which a considerable amount is stored in tidal marsh soils. Large uncertainties still exist with respect to the amount and controlling factors of soil organic carbon (SOC) stored in these ecosystems. Moreover, most research has focused on SOC dynamics of saltmarshes, while brackish and freshwater marshes are often even more productive and thus receive even larger organic carbon inputs. Therefore, in this study the OC dynamics of tidal marsh soils along an estuarine gradient are studied in order to contribute to our knowledge of 1) the stocks, 2) the controlling factors and 3) the fate of SOC in tidal marshes with different environmental characteristics. This research thus contributes to a better understanding of the potential of coastal environments to store organic carbon under future climatic changes. Soil and vegetation samples are collected in tidal salt-, brackish- and freshwater marshes in the Scheldt estuary (Belgium - The Netherlands). At each tidal marsh, three replicate soil cores up to 1.5m depth in 0.03m increments are collected at locations with both a low and a high elevation. These cores are analyzed for OC, stable C and N isotopes, bulk density and texture. Incubation experiments of topsoil samples were conducted and both aboveground and belowground biomass were collected. The results show that SOC stocks (range: 13,5 - 35,4 kg OC m-2), standing biomass (range: 2000 - 7930 g DW m-2) and potential soil respiration of CO2 (range: 0,03 - 0,12 % per unit OC per day) decrease with increasing salinity. This shows that both the amount of OC from local macrophytes and the quality of the organic matter are important factors controlling the SOC stocks. In addition, based on the analysis of stable C and N isotopes, it appears that when a significant fraction of SOC is derived from local macrophytes, higher SOC stocks are

  10. LCM-seq reveals the crucial role of LsSOC1 in heat-promoted bolting of lettuce (Lactuca sativa L.).

    Science.gov (United States)

    Chen, Zijing; Zhao, Wensheng; Ge, Danfeng; Han, Yingyan; Ning, Kang; Luo, Chen; Wang, Shenglin; Liu, Renyi; Zhang, Xiaolan; Wang, Qian

    2018-05-17

    Lettuce (Lactuca sativa L.) is one of the most economically important vegetables. The floral transition in lettuce is accelerated under high temperatures, which can significantly decrease yields. However, the molecular mechanism underlying the floral tranition in lettuce is poorly known. Using laser capture microdissection coupled with RNA sequencing, we isolated shoot apical meristem cells from the bolting-sensitive lettuce line S39 at four critical stages of development. Subsequently, we screened specifically for the flowering-related gene LsSOC1 during the floral transition through comparative transcriptomic analysis. Molecular biology, developmental biology, and biochemical tools were combined to investigate the biological function of LsSOC1 in lettuce. LsSOC1 knockdown by RNA interference resulted in a significant delay in the timing of bolting and insensitivity to high temperature, which indicated that LsSOC1 functions as an activator during heat-promoted bolting in lettuce. We determined that two heat-shock transcription factors, HsfA1e and HsfA4c, bound to the promoter of LsSOC1 to confirm that LsSOC1 played an important role in heat-promoted bolting. This study indicates that LsSOC1 plays a crucial role in the heat-promoted bolting process in lettuce. Further investigation of LsSOC1 may be useful for clarification of the bolting mechanism in lettuce. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  11. Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance.

    Science.gov (United States)

    Tellechea, M L; Steinhardt, A Penas; Rodriguez, G; Taverna, M J; Poskus, E; Frechtel, G

    2013-05-01

    Specific Suppressor of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. 780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (p = 0.005) and abdominal obesity (p = 0.002) and allele C carriers showed, in comparison with TT carriers, lower BMI (p = 0.001) and waist circumference (p = 0.001). rs8074124CC- carriers showed lower fasting insulin (p = 0.017) and HOMA-IR (p = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (p = 0.009) and hypertriglyceridemic waist (p = 0.006). rs12051836CC- carriers showed lower fasting insulin (p = 0.043) and HOMA-IR (p = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (p = 0.026) and HDL-C (p = 0.014) as a continuous variable. We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders. Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.

  12. Selection of key terrain attributes for SOC model

    DEFF Research Database (Denmark)

    Greve, Mogens Humlekrog; Adhikari, Kabindra; Chellasamy, Menaka

    As an important component of the global carbon pool, soil organic carbon (SOC) plays an important role in the global carbon cycle. SOC pool is the basic information to carry out global warming research, and needs to sustainable use of land resources. Digital terrain attributes are often use...... was selected, total 2,514,820 data mining models were constructed by 71 differences grid from 12m to 2304m and 22 attributes, 21 attributes derived by DTM and the original elevation. Relative importance and usage of each attributes in every model were calculated. Comprehensive impact rates of each attribute...

  13. A Framework for Hardware-Accelerated Services Using Partially Reconfigurable SoCs

    Directory of Open Access Journals (Sweden)

    MACHIDON, O. M.

    2016-05-01

    Full Text Available The current trend towards ?Everything as a Service? fosters a new approach on reconfigurable hardware resources. This innovative, service-oriented approach has the potential of bringing a series of benefits for both reconfigurable and distributed computing fields by favoring a hardware-based acceleration of web services and increasing service performance. This paper proposes a framework for accelerating web services by offloading the compute-intensive tasks to reconfigurable System-on-Chip (SoC devices, as integrated IP (Intellectual Property cores. The framework provides a scalable, dynamic management of the tasks and hardware processing cores, based on dynamic partial reconfiguration of the SoC. We have enhanced security of the entire system by making use of the built-in detection features of the hardware device and also by implementing active counter-measures that protect the sensitive data.

  14. Systems engineering and analysis

    CERN Document Server

    Blanchard, Benjamin S

    2010-01-01

    For senior-level undergraduate and first and second year graduate systems engineering and related courses. A total life-cycle approach to systems and their analysis. This practical introduction to systems engineering and analysis provides the concepts, methodologies, models, and tools needed to understand and implement a total life-cycle approach to systems and their analysis. The authors focus first on the process of bringing systems into being--beginning with the identification of a need and extending that need through requirements determination, functional analysis and allocation, design synthesis, evaluation, and validation, operation and support, phase-out, and disposal. Next, the authors discuss the improvement of systems currently in being, showing that by employing the iterative process of analysis, evaluation, feedback, and modification, most systems in existence can be improved in their affordability, effectiveness, and stakeholder satisfaction.

  15. A cost-benefit analysis of methods for the determination of biomass concentration in wastewater treatment.

    Science.gov (United States)

    Hernandez, J E; Bachmann, R T; Edyvean, R G J

    2006-01-01

    The measurement of biomass concentration is important in biological wastewater treatment. This paper compares the accuracy and costs of the traditional volatile suspended solids (VSS) and the proposed suspended organic carbon (SOC) methods. VSS and SOC values of a dilution system were very well correlated (R(2)=0.9995). VSS and SOC of 16 samples were determined, the mean SOC/VSS ratio (0.52, n=16, sigma=0.01) was close to the theoretical value (0.53). For costing analysis, two hypothetical cases were analysed. In case A, it is assumed that 108 samples are analysed annually from two continuous reactors. Case B represents a batch experiment to be carried out in 24 incubated serum bottles. The savings, when using the SOC method, were 11,987 pounds for case A and 90 pounds for case B. This study suggests the use of SOC method as a time saving and lower cost biomass concentration measurement.

  16. Wind energy analysis system

    OpenAIRE

    2014-01-01

    M.Ing. (Electrical & Electronic Engineering) One of the most important steps to be taken before a site is to be selected for the extraction of wind energy is the analysis of the energy within the wind on that particular site. No wind energy analysis system exists for the measurement and analysis of wind power. This dissertation documents the design and development of a Wind Energy Analysis System (WEAS). Using a micro-controller based design in conjunction with sensors, WEAS measure, calcu...

  17. Molecular Cloning, Characterization, and Expression of MiSOC1: A Homolog of the Flowering Gene SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 from Mango (Mangifera indica L)

    Science.gov (United States)

    Wei, Junya; Liu, Debing; Liu, Guoyin; Tang, Jie; Chen, Yeyuan

    2016-01-01

    MADS-box transcription factor plays a crucial role in plant development, especially controlling the formation and development of floral organs. Mango (Mangifera indica L) is an economically important fruit crop, but its molecular control of flowering is largely unknown. To better understand the molecular basis of flowering regulation in mango, we isolated and characterized the MiSOC1, a putative mango orthologs for the Arabidopsis SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1/AGAMOUS-LIKE 20 (SOC1/AGL20) with homology-based cloning and RACE. The full-length cDNA (GenBank accession No.: KP404094) is 945 bp in length including a 74 bp long 5′ UTR and a 189 bp long 3′ UTR and the open reading frame was 733 bps, encoding 223 amino acids with molecular weight 25.6 kD. Both sequence alignment and phylogenetic analysis all indicated that deduced protein contained a conservative MADS-box and semi-conservative K domain and belonged to the SOC1/TM3 subfamily of the MADS-box family. Quantitative real-time PCR was performed to investigate the expression profiles of MiSOC1 gene in different tissues/organs including root, stem, leaves, flower bud, and flower. The result indicated MiSOC1 was widely expressed at different levels in both vegetative and reproductive tissues/organs with the highest expression level in the stems’ leaves and inflorescences, low expression in roots and flowers. The expression of MiSOC1 in different flower developmental stages was different while same tissue –specific pattern among different varieties. In addition, MiSOC1 gene expression was affect by ethephon while high concentration ethephon inhibit the expression of MiSOC1. Overexpression of MiSOC1 resulted in early flowering in Arabidopsis. In conclusion, these results suggest that MiSOC1 may act as induce flower function in mango. PMID:27965680

  18. Molecular Cloning, Characterization, and Expression of MiSOC1: A Homolog of the Flowering Gene SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 from Mango (Mangifera indica L).

    Science.gov (United States)

    Wei, Junya; Liu, Debing; Liu, Guoyin; Tang, Jie; Chen, Yeyuan

    2016-01-01

    MADS-box transcription factor plays a crucial role in plant development, especially controlling the formation and development of floral organs. Mango ( Mangifera indica L) is an economically important fruit crop, but its molecular control of flowering is largely unknown. To better understand the molecular basis of flowering regulation in mango, we isolated and characterized the MiSOC1, a putative mango orthologs for the Arabidopsis SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1/AGAMOUS-LIKE 20 (SOC1/AGL20) with homology-based cloning and RACE. The full-length cDNA (GenBank accession No.: KP404094) is 945 bp in length including a 74 bp long 5' UTR and a 189 bp long 3' UTR and the open reading frame was 733 bps, encoding 223 amino acids with molecular weight 25.6 kD. Both sequence alignment and phylogenetic analysis all indicated that deduced protein contained a conservative MADS-box and semi-conservative K domain and belonged to the SOC1/TM3 subfamily of the MADS-box family. Quantitative real-time PCR was performed to investigate the expression profiles of MiSOC1 gene in different tissues/organs including root, stem, leaves, flower bud, and flower. The result indicated MiSOC1 was widely expressed at different levels in both vegetative and reproductive tissues/organs with the highest expression level in the stems' leaves and inflorescences, low expression in roots and flowers. The expression of MiSOC1 in different flower developmental stages was different while same tissue -specific pattern among different varieties. In addition, MiSOC1 gene expression was affect by ethephon while high concentration ethephon inhibit the expression of MiSOC1. Overexpression of MiSOC1 resulted in early flowering in Arabidopsis . In conclusion, these results suggest that MiSOC1 may act as induce flower function in mango.

  19. A configurable and low-power mixed signal SoC for portable ECG monitoring applications.

    Science.gov (United States)

    Kim, Hyejung; Kim, Sunyoung; Van Helleputte, Nick; Artes, Antonio; Konijnenburg, Mario; Huisken, Jos; Van Hoof, Chris; Yazicioglu, Refet Firat

    2014-04-01

    This paper describes a mixed-signal ECG System-on-Chip (SoC) that is capable of implementing configurable functionality with low-power consumption for portable ECG monitoring applications. A low-voltage and high performance analog front-end extracts 3-channel ECG signals and single channel electrode-tissue-impedance (ETI) measurement with high signal quality. This can be used to evaluate the quality of the ECG measurement and to filter motion artifacts. A custom digital signal processor consisting of 4-way SIMD processor provides the configurability and advanced functionality like motion artifact removal and R peak detection. A built-in 12-bit analog-to-digital converter (ADC) is capable of adaptive sampling achieving a compression ratio of up to 7, and loop buffer integration reduces the power consumption for on-chip memory access. The SoC is implemented in 0.18 μm CMOS process and consumes 32 μ W from a 1.2 V while heart beat detection application is running, and integrated in a wireless ECG monitoring system with Bluetooth protocol. Thanks to the ECG SoC, the overall system power consumption can be reduced significantly.

  20. Design of a Programmable Passive SoC for Biomedical Applications Using RFID ISO 15693/NFC5 Interface

    Directory of Open Access Journals (Sweden)

    Mayukh Bhattacharyya

    2018-01-01

    Full Text Available Low power, low cost inductively powered passive biotelemetry system involving fully customized RFID/NFC interface base SoC has gained popularity in the last decades. However, most of the SoCs developed are application specific and lacks either on-chip computational or sensor readout capability. In this paper, we present design details of a programmable passive SoC in compliance with ISO 15693/NFC5 standard for biomedical applications. The integrated system consists of a 32-bit microcontroller, a sensor readout circuit, a 12-bit SAR type ADC, 16 kB RAM, 16 kB ROM and other digital peripherals. The design is implemented in a 0.18 μ m CMOS technology and used a die area of 1.52 mm × 3.24 mm. The simulated maximum power consumption of the analog block is 592 μ W. The number of external components required by the SoC is limited to an external memory device, sensors, antenna and some passive components. The external memory device contains the application specific firmware. Based on the application, the firmware can be modified accordingly. The SoC design is suitable for medical implants to measure physiological parameters like temperature, pressure or ECG. As an application example, the authors have proposed a bioimplant to measure arterial blood pressure for patients suffering from Peripheral Artery Disease (PAD.

  1. Fiscal system analysis - contractual systems

    International Nuclear Information System (INIS)

    Kaiser, M.J.

    2006-01-01

    Production sharing contracts are one of the most popular forms of contractual system used in petroleum agreements around the world, but the manner in which the fiscal terms and contract parameters impact system measures is complicated and not well understood. The purpose of this paper is to quantify the influence of private and market uncertainty in contractual fiscal systems. A meta-modelling approach is employed that couples the results of a simulation model with regression analysis to construct numerical functionals that quantify the fiscal regime. Relationships are derived that specify how the present value, rate of return, and take statistics vary as a function of the system parameters. The deepwater Girassol field development in Angola is taken as a case study. (author)

  2. A 0.7-V 17.4- μ W 3-lead wireless ECG SoC.

    Science.gov (United States)

    Khayatzadeh, Mahmood; Zhang, Xiaoyang; Tan, Jun; Liew, Wen-Sin; Lian, Yong

    2013-10-01

    This paper presents a fully integrated sub-1 V 3-lead wireless ECG System-on-Chip (SoC) for wireless body sensor network applications. The SoC includes a two-channel ECG front-end with a driven-right-leg circuit, an 8-bit SAR ADC, a custom-designed 16-bit microcontroller, two banks of 16 kb SRAM, and a MICS band transceiver. The microcontroller and SRAM blocks are able to operate at sub-/near-threshold regime for the best energy consumption. The proposed SoC has been implemented in a standard 0.13- μ m CMOS process. Measurement results show the microcontroller consumes only 2.62 pJ per instruction at 0.35 V . Both microcontroller and memory blocks are functional down to 0.25 V. The entire SoC is capable of working at single 0.7-V supply. At the best case, it consumes 17.4 μ W in heart rate detection mode and 74.8 μW in raw data acquisition mode under sampling rate of 500 Hz. This makes it one of the best ECG SoCs among state-of-the-art biomedical chips.

  3. 0.45 v and 18 μA/MHz MCU SOC with Advanced Adaptive Dynamic Voltage Control (ADVC

    Directory of Open Access Journals (Sweden)

    Uzi Zangi

    2018-05-01

    Full Text Available An ultra-low-power MicroController Unit System-on-Chip (MCU SOC is described with integrated DC to DC power management and Adaptive Dynamic Voltage Control (ADVC mechanism. The SOC, designed and fabricated in a 40 nm ULP standard CMOS technology, includes the complete Synopsys ARC EM5D core MCU, featuring a full set of DSP instructions and minimizing energy consumption at a wide range of frequencies: 312 K–80 MHz. A number of unique low voltage digital libraries, comprising of approximately 300 logic cells and sequential elements, were used for the MCU SOC design. On-die silicon sensors were utilized to continuously change the operating voltage to optimize power/performance for a given frequency and environmental conditions, and also to resolve yield and life time problems, while operating at low voltages. A First Fail (FFail mechanism, which can be digitally and linearly controlled with up to 8 bits, detects the failing SOC voltage at a given frequency. The core operates between 0.45–1.1 V volts with a direct battery connection for an input voltage of 1.6–3.6 V. Measurement results show that the peak energy efficiency is 18μW/MHz. A comparison to state-of-the-art commercial SOCs is presented, showing a 3–5× improved current/DMIPS (Dhrystone Million Instructions per second compared to the next best chip.

  4. A Generalized SOC-OCV Model for Lithium-Ion Batteries and the SOC Estimation for LNMCO Battery

    Directory of Open Access Journals (Sweden)

    Caiping Zhang

    2016-11-01

    Full Text Available A state-of-charge (SOC versus open-circuit-voltage (OCV model developed for batteries should preferably be simple, especially for real-time SOC estimation. It should also be capable of representing different types of lithium-ion batteries (LIBs, regardless of temperature change and battery degradation. It must therefore be generic, robust and adaptive, in addition to being accurate. These challenges have now been addressed by proposing a generalized SOC-OCV model for representing a few most widely used LIBs. The model is developed from analyzing electrochemical processes of the LIBs, before arriving at the sum of a logarithmic, a linear and an exponential function with six parameters. Values for these parameters are determined by a nonlinear estimation algorithm, which progressively shows that only four parameters need to be updated in real time. The remaining two parameters can be kept constant, regardless of temperature change and aging. Fitting errors demonstrated with different types of LIBs have been found to be within 0.5%. The proposed model is thus accurate, and can be flexibly applied to different LIBs, as verified by hardware-in-the-loop simulation designed for real-time SOC estimation.

  5. Analysis of Minimal LDPC Decoder System on a Chip Implementation

    Directory of Open Access Journals (Sweden)

    T. Palenik

    2015-09-01

    Full Text Available This paper presents a practical method of potential replacement of several different Quasi-Cyclic Low-Density Parity-Check (QC-LDPC codes with one, with the intention of saving as much memory as required to implement the LDPC encoder and decoder in a memory-constrained System on a Chip (SoC. The presented method requires only a very small modification of the existing encoder and decoder, making it suitable for utilization in a Software Defined Radio (SDR platform. Besides the analysis of the effects of necessary variable-node value fixation during the Belief Propagation (BP decoding algorithm, practical standard-defined code parameters are scrutinized in order to evaluate the feasibility of the proposed LDPC setup simplification. Finally, the error performance of the modified system structure is evaluated and compared with the original system structure by means of simulation.

  6. Daily Socs1 rhythms alter with aging differentially in peripheral clocks in male Wistar rats: therapeutic effects of melatonin.

    Science.gov (United States)

    Vinod, Ch; Jagota, Anita

    2017-06-01

    Suprachiasmatic nucleus (SCN) in synchronization with the peripheral clocks regulates the temporal oscillations leading to overt rhythms. Aging leads to attenuation of such circadian regulation, accompanied by increased inflammatory mediators prevalently the cytokines. Suppressors of cytokine signaling (SOCS) family of proteins such as SOCS 1, 3 and cytokine-inducible SH2-containing protein (CIS) negatively regulate the cytokine signaling pathway. The role of SOCS1 in aging and circadian system is obscure. We therefore studied the daily rhythms of rSocs1 mRNA expression at Zeitgeber time (ZT) -0, 6, 12 and 18 in peripheral clocks such as liver, kidney, intestine and heart of 3, 12 and 24 months (m) old male Wistar rats. Interestingly the peripheral clocks studied displayed a rhythmic rSocs1 gene expression in 3 months. In 12 months group, 12 h phase advance in liver and 12 h phase delay in kidney and heart was observed with abolition of rhythms in intestine. Aging (24 months group) resulted in a phase advance by 6 h in liver and heart with abolition of rhythms in intestine in 24 months group. Kidney was also significantly affected upon aging with significant decrease in the rSocs1 levels and abolition of rhythms. The decrease in melatonin levels with aging is associated with decreased immunity and increased oxidative stress. The exogenous administration of melatonin has been linked to play a role in re-synchronization of circadian rhythms, reducing oxidative stress and enhancing immune properties. We therefore had studied the effect of exogenous melatonin upon age induced changes in daily rSocs1 gene expression patterns. Melatonin treatment partially restored the rhythms and daily pulse (ratio of maximum:minimum levels) in liver and intestine in 12 months group. Melatonin administration resulted in a significant increase in mean 24 h rSocs1 expression in intestine and heart of 24 months group compared to that of 3 months. The melatonin administration

  7. Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.

    Directory of Open Access Journals (Sweden)

    Eva-K Pauli

    2008-11-01

    Full Text Available The type I interferon (IFN system is a first line of defense against viral infections. Viruses have developed various mechanisms to counteract this response. So far, the interferon antagonistic activity of influenza A viruses was mainly observed on the level of IFNbeta gene induction via action of the viral non-structural protein 1 (NS1. Here we present data indicating that influenza A viruses not only suppress IFNbeta gene induction but also inhibit type I IFN signaling through a mechanism involving induction of the suppressor of cytokine signaling-3 (SOCS-3 protein. Our study was based on the observation that in cells that were infected with influenza A virus and subsequently stimulated with IFNalpha/beta, phosphorylation of the signal transducer and activator of transcription protein 1 (STAT1 was strongly reduced. This impaired STAT1 activation was not due to the action of viral proteins but rather appeared to be induced by accumulation of viral 5' triphosphate RNA in the cell. SOCS proteins are potent endogenous inhibitors of Janus kinase (JAK/STAT signaling. Closer examination revealed that SOCS-3 but not SOCS-1 mRNA levels increase in an RNA- and nuclear factor kappa B (NF-kappaB-dependent but type I IFN-independent manner early in the viral replication cycle. This direct viral induction of SOCS-3 mRNA and protein expression appears to be relevant for suppression of the antiviral response since in SOCS-3 deficient cells a sustained phosphorylation of STAT1 correlated with elevated expression of type I IFN-dependent genes. As a consequence, progeny virus titers were reduced in SOCS-3 deficient cells or in cells were SOCS-3 expression was knocked-down by siRNA. These data provide the first evidence that influenza A viruses suppress type I IFN signaling on the level of JAK/STAT activation. The inhibitory effect is at least in part due to the induction of SOCS-3 gene expression, which results in an impaired antiviral response.

  8. Performance Evaluation of FIR Filter After Implementation on Different FPGA and SOC and Its Utilization in Communication and Network

    DEFF Research Database (Denmark)

    Pandey, Bishwajeet; Das, Bhagwan; Kaur, Amanpreet

    2017-01-01

    that will energy efficient as well as faster than traditional design. Three different FPGA and SOC are taken under consideration and our design is implemented on these four ICs and we find the most energy efficient architecture and also find the architecture that will deliver highest performance among these four...... FPGA then we conclude that Zynq 7000 All programmable SOC is power hungry architecture and Kintex ultrascale architecture is the most energy efficient architecture that dissipates 20.86% less power than Zynq 700 All programmable SOC. For performance evaluation, we have taken benchmark C code of FIR...... provide by Xilinx. We transform that C code into HDL using Vivado HLS 2016.2 before power analysis on Vivado 2016.2. Ultrascale FPGA is generally used for packet processing in 100G networking and heterogeneous wireless infrastructure....

  9. SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced Inflammation In Vivo

    Directory of Open Access Journals (Sweden)

    João Antônio Chaves de Souza

    2013-01-01

    Full Text Available SOCS3 is an inducible endogenous negative regulator of JAK/STAT pathway, which is relevant in inflammatory conditions. We used a model of LPS-induced periodontal disease in rats to correlate SOCS3 expression with the inflammatory status. In vitro we used a murine macrophage cell line to assess the physical interaction between SOCS3 and STAT3 by coimmunoprecipitation. 30 ug of LPS from Escherichia coli were injected in the gingival tissues on the palatal aspect of first molars of the animals 3x/week for up to 4 weeks. Control animals were injected with the vehicle (PBS. The rats were sacrificed at 7, 15, and 30 days. Inflammation and gene expression were assessed by stereometric analysis, immunohistochemistry, RT-qPCR, and western blot. LPS injections increased inflammation, paralleled by an upregulation of SOCS3, of the proinflammatory cytokines IL-1β, IL-6, and TNF-α and increased phosphorylation of STAT3 and p38 MAPK. SOCS3 expression accompanied the severity of inflammation and the expression of proinflammatory cytokines, as well as the activation status of STAT3 and p38 MAPK. LPS stimulation in a macrophage cell line in vitro induced transient STAT3 activation, which was inversely correlated with a dynamic physical interaction with SOCS3, suggesting that this may be a mechanism for SOCS3 regulatory function.

  10. Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector

    International Nuclear Information System (INIS)

    Zhou Hongsheng; Zhang Donghua; Wang Yaya; Dai Ming; Zhang Lu; Liu Wenli; Liu Dan; Tan Huo; Huang Zhenqian

    2006-01-01

    CML28 is an attractive target for antigen-specific immunotherapy. SOCS1 represents an inhibitory control mechanism for DC antigen presentation and the magnitude of adaptive immunity. In this study, we evaluated the potential for inducing CML28-specific cytotoxic T lymphocytes (CTL) responses by dendritic cells (DCs)-based vaccination. We constructed a CML28 DNA vaccine and a SOCS1 siRNA vector and then cotransfect monocyte-derived DCs. Flow cytometry analysis showed gene silencing of SOCS1 resulted in higher expressions of costimulative moleculars in DCs. Mixed lymphocyte reaction (MLR) indicated downregulation of SOCS1 stronger capability to stimulate proliferation of responder cell in DCs. The CTL assay revealed transfected DCs effectively induced autologous CML28-specific CTL responses and the lytic activities induced by SOCS1-silenced DCs were significantly higher compared with those induced by SOCS1-expressing DCs. These results in our study indicates gene silencing of SOCS1 remarkably enhanced the cytotoxicity efficiency of CML28 DNA vaccine in DCs

  11. PWR systems transient analysis

    International Nuclear Information System (INIS)

    Kennedy, M.F.; Peeler, G.B.; Abramson, P.B.

    1985-01-01

    Analysis of transients in pressurized water reactor (PWR) systems involves the assessment of the response of the total plant, including primary and secondary coolant systems, steam piping and turbine (possibly including the complete feedwater train), and various control and safety systems. Transient analysis is performed as part of the plant safety analysis to insure the adequacy of the reactor design and operating procedures and to verify the applicable plant emergency guidelines. Event sequences which must be examined are developed by considering possible failures or maloperations of plant components. These vary in severity (and calculational difficulty) from a series of normal operational transients, such as minor load changes, reactor trips, valve and pump malfunctions, up to the double-ended guillotine rupture of a primary reactor coolant system pipe known as a Large Break Loss of Coolant Accident (LBLOCA). The focus of this paper is the analysis of all those transients and accidents except loss of coolant accidents

  12. Multidisciplinary System Reliability Analysis

    Science.gov (United States)

    Mahadevan, Sankaran; Han, Song; Chamis, Christos C. (Technical Monitor)

    2001-01-01

    The objective of this study is to develop a new methodology for estimating the reliability of engineering systems that encompass multiple disciplines. The methodology is formulated in the context of the NESSUS probabilistic structural analysis code, developed under the leadership of NASA Glenn Research Center. The NESSUS code has been successfully applied to the reliability estimation of a variety of structural engineering systems. This study examines whether the features of NESSUS could be used to investigate the reliability of systems in other disciplines such as heat transfer, fluid mechanics, electrical circuits etc., without considerable programming effort specific to each discipline. In this study, the mechanical equivalence between system behavior models in different disciplines are investigated to achieve this objective. A new methodology is presented for the analysis of heat transfer, fluid flow, and electrical circuit problems using the structural analysis routines within NESSUS, by utilizing the equivalence between the computational quantities in different disciplines. This technique is integrated with the fast probability integration and system reliability techniques within the NESSUS code, to successfully compute the system reliability of multidisciplinary systems. Traditional as well as progressive failure analysis methods for system reliability estimation are demonstrated, through a numerical example of a heat exchanger system involving failure modes in structural, heat transfer and fluid flow disciplines.

  13. Cache Performance Optimization for SoC Vedio Applications

    OpenAIRE

    Lei Li; Wei Zhang; HuiYao An; Xing Zhang; HuaiQi Zhu

    2014-01-01

    Chip Multiprocessors (CMPs) are adopted by industry to deal with the speed limit of the single-processor. But memory access has become the bottleneck of the performance, especially in multimedia applications. In this paper, a set of management policies is proposed to improve the cache performance for a SoC platform of video application. By analyzing the behavior of Vedio Engine, the memory-friendly writeback and efficient prefetch policies are adopted. The experiment platform is simulated by ...

  14. Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity.

    Science.gov (United States)

    Ali, Omar; Cerjak, Diana; Kent, Jack W; James, Roland; Blangero, John; Carless, Melanie A; Zhang, Yi

    2016-09-01

    Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment and may play an important role in the obesity epidemic. We assessed the relationship between DNA methylation and obesity in peripheral blood mononuclear cells (PBMCs) at 485,000 CpG sites across the genome in family members (8-90 y of age) using a discovery cohort (192 individuals) and a validation cohort (1,052 individuals) of Northern European ancestry. After Bonferroni-correction (P α=0.05 = 1.31 × 10 -7 ) for genome-wide significance, we identified 3 loci, cg18181703 (SOCS3), cg04502490 (ZNF771), and cg02988947 (LIMD2), where methylation status was associated with body mass index percentile (BMI%), a clinical index for obesity in children, adolescents, and adults. These sites were also associated with multiple metabolic syndrome (MetS) traits, including central obesity, fat depots, insulin responsiveness, and plasma lipids. The SOCS3 methylation locus was also associated with the clinical definition of MetS. In the validation cohort, SOCS3 methylation status was found to be inversely associated with BMI% (P = 1.75 × 10 -6 ), waist to height ratio (P = 4.18 × 10 -7 ), triglycerides (P = 4.01 × 10 -4 ), and MetS (P = 4.01 × 10 -7 ), and positively correlated with HDL-c (P = 4.57 × 10 -8 ). Functional analysis in a sub cohort (333 individuals) demonstrated SOCS3 methylation and gene expression in PBMCs were inversely correlated (P = 2.93 × 10 -4 ) and expression of SOCS3 was positively correlated with status of MetS (P = 0.012). We conclude that epigenetic modulation of SOCS3, a gene involved in leptin and insulin signaling, may play an important role in obesity and MetS.

  15. An OCP Compliant Network Adapter for GALS-based SoC Design Using the MANGO Network-on-Chip

    DEFF Research Database (Denmark)

    Bjerregaard, Tobias; Mahadevan, Shankar; Olsen, Rasmus Grøndahl

    2005-01-01

    decouples communication and computation, providing memory-mapped OCP transactions based on primitive message-passing services of the network. Also, it facilitates GALS-type systems, by adapting to the clockless network. This helps leverage a modular SoC design flow. We evaluate performance and cost of 0...

  16. Approche complète de développement des IPs pour les SoCs A ...

    African Journals Online (AJOL)

    CoFluent and Quartus II tools have helped us to get the different models. ... Key words : IPs – SoC - Design and Reuse – UML – System C ... nouvelles techniques de conception doivent- .... obtenir un prototype fabriqué et testé. ..... Information Technology and Control, ... A new logic circuit design methodology with UMLl.

  17. SOCS-1 deficiency does not prevent diet-induced insulin resistance

    DEFF Research Database (Denmark)

    Emanuelli, Brice; Macotela, Yazmin; Boucher, Jérémie

    2008-01-01

    Obesity is associated with inflammation and increased expression of suppressor of cytokine signaling (SOCS) proteins, which inhibit cytokine and insulin signaling. Thus, reducing SOCS expression could prevent the development of obesity-induced insulin resistance. Using SOCS-1 knockout mice, we...... investigated the contribution of SOCS-1 in the development of insulin resistance induced by a high-fat diet (HFD). SOCS-1 knockout mice on HFD gained 70% more weight, displayed a 2.3-fold increase in epididymal fat pads mass and increased hepatic lipid content. This was accompanied by increased mRNA expression...... of leptin and the macrophage marker CD68 in white adipose tissue and of SREBP1c and FAS in liver. HFD also induced hyperglycemia in SOCS-1 deficient mice with impairment of glucose and insulin tolerance tests. Thus, despite the role of SOCS proteins in obesity-related insulin resistance, SOCS-1 deficiency...

  18. Power System Analysis

    Science.gov (United States)

    Taniguchi, Haruhito

    Electric power generation that relies on various sources as the primary sources of energy is expected to bring down CO2 emissions levels to support the overall strategy to curb global warming. Accordingly, utilities are moving towards integrating more renewable sources for generation, mostly dispersed, and adopting Smart Grid Technologies for system control. In order to construct, operate, and maintain power systems stably and economically in such background, thorough understanding about the characteristics of power systems and their components is essential. This paper presents modeling and simulation techniques available for the analysis of critical aspects such as thermal capacity, stability, voltage stability, and frequency dynamics, vital for the stable operation of power systems.

  19. SOCS-1 Localizes to the Microtubule Organizing Complex-Associated 20S Proteasome

    OpenAIRE

    Vuong, Bao Q.; Arenzana, Teresita L.; Showalter, Brian M.; Losman, Julie; Chen, X. Peter; Mostecki, Justin; Banks, Alexander S.; Limnander, Andre; Fernandes, Neil; Rothman, Paul B.

    2005-01-01

    The regulation of cytokine signaling is critical for controlling cellular proliferation and activation during an immune response. SOCS-1 is a potent inhibitor of Jak kinase activity and of signaling initiated by several cytokines. SOCS-1 protein levels are tightly regulated, and recent data suggest that SOCS-1 may regulate the protein levels of some signaling proteins by the ubiquitin proteasome pathway; however, the cellular mechanism by which SOCS-1 directs proteins for degradation is unkno...

  20. DMPD: Regulation of cytokine signaling by SOCS family molecules. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 14644140 Regulation of cytokine signaling by SOCS family molecules. Fujimoto M, Nak...a T. Trends Immunol. 2003 Dec;24(12):659-66. (.png) (.svg) (.html) (.csml) Show Regulation of cytokine signaling by SOCS family... molecules. PubmedID 14644140 Title Regulation of cytokine signaling by SOCS family molec

  1. The fate of SOC during the processes of water erosion and subsequent deposition: a field study.

    Science.gov (United States)

    van Hemelryck, H.; Govers, G.; van Oost, K.; Merckx, R.

    2009-04-01

    Globally soils are the largest terrestrial pool of carbon (C). A relatively small increase or decrease in soil carbon content due to changes in land use or management practices could therefore result in a significant net exchange of C between the soil C reservoir and the atmosphere. As such, the geomorphic processes of water and tillage erosion have been identified to significantly impact on this large pool of soil organic carbon (SOC). Soil erosion, transport and deposition not only result in redistribution of sediments and associated carbon within a landscape, but also affect the exchange of C between the pedosphere and the atmosphere. The direction and magnitude of an erosion-induced change in the global C balance is however a topic of much debate as opposing processes interact: i) At eroding sites a net uptake of C could be the result of reduced respiration rates and continued inputs of newly produced carbon. ii) Colluvial deposition of eroded sediment and SOC leads to the burial of the original topsoil and this may constrain the decomposition of its containing SOC. iii) Eroded sediment could be transported to distal depositional environments or fluvial systems where it will either be conserved or become rapidly mineralized. iv) Increased emission of CO2 due to erosion may result from the disruptive energy of erosive forces causing the breakdown of aggregates and exposing previously protected SOC to microbial decomposition. The above-mentioned processes show a large spatial and temporal variability and assessing their impact requires an integrated modeling approach. However uncertainties about the basic processes that accompany SOC displacement are still large. This study focuses on one of these large information gaps: the fate of eroded and subsequently deposited SOC. A preceding experimental study (Van Hemelryck et al., 2008) was used to identify controlling factors (erosional intensity, changes in soil structure,…). However this experimental research

  2. VENTILATION TECHNOLOGY SYSTEMS ANALYSIS

    Science.gov (United States)

    The report gives results of a project to develop a systems analysis of ventilation technology and provide a state-of-the-art assessment of ventilation and indoor air quality (IAQ) research needs. (NOTE: Ventilation technology is defined as the hardware necessary to bring outdoor ...

  3. Energy efficient HPC on embedded SoCs : optimization techniques for mali GPU

    OpenAIRE

    Grasso, Ivan; Radojkovic, Petar; Rajovic, Nikola; Gelado Fernandez, Isaac; Ramírez Bellido, Alejandro

    2014-01-01

    A lot of effort from academia and industry has been invested in exploring the suitability of low-power embedded technologies for HPC. Although state-of-the-art embedded systems-on-chip (SoCs) inherently contain GPUs that could be used for HPC, their performance and energy capabilities have never been evaluated. Two reasons contribute to the above. Primarily, embedded GPUs until now, have not supported 64-bit floating point arithmetic - a requirement for HPC. Secondly, embedded GPUs did not pr...

  4. SOCS proteins in regulation of receptor tyrosine kinase signaling

    DEFF Research Database (Denmark)

    Kazi, Julhash U.; Kabir, Nuzhat N.; Flores Morales, Amilcar

    2014-01-01

    Receptor tyrosine kinases (RTKs) are a family of cell surface receptors that play critical roles in signal transduction from extracellular stimuli. Many in this family of kinases are overexpressed or mutated in human malignancies and thus became an attractive drug target for cancer treatment....... The signaling mediated by RTKs must be tightly regulated by interacting proteins including protein-tyrosine phosphatases and ubiquitin ligases. The suppressors of cytokine signaling (SOCS) family proteins are well-known negative regulators of cytokine receptors signaling consisting of eight structurally similar...

  5. EtherBone - A Network Layer for the Wishbone SoC Bus

    CERN Document Server

    Kreider, M; Lewis, J; Włostowski, T; Serrano, J

    2011-01-01

    Today, there are several System on a Chip (SoC) bus systems. Typically, these buses are confined on-chip and rely on higher level components to communicate with the outside world. Taking these systems a step further, we see the possibility of extending the reach of the SoC bus to remote FPGAs or processors. This leads to the idea of the EtherBone (EB) core, which connects a Wishbone (WB) Ver. 4 Bus via a Gigabit Ethernet based network link to remote peripheral devices. EB acts as a transparent interconnect module towards attached WB Bus devices. Address information and data from one or more WB bus cycles is preceded with a descriptive header and encapsulated in a UDP/IP packet. Because of this standard compliance, EB is able to traverse Wide Area Networks and is therefore not bound to a geographic location. Due to the low level nature of the WB bus, EB provides a sound basis for remote hardware tools like a JTAG debugger, In-System-Programmer (ISP), boundary scan interface or logic analyser module. EB was de...

  6. ETHERBONE - a network layer for the wishbone SoC bus

    International Nuclear Information System (INIS)

    Kreider, M.; Terpstra, W.; Lewis, J.; Serrano, J.; Wlostowski, T.

    2012-01-01

    Today, there are several System on a Chip (SoC) bus systems. Typically, these buses are confined on-chip and rely on higher level components to communicate with the outside world. Taking these systems a step further, we see the possibility of extending the reach of the SoC bus to remote FPGAs or processors. This leads to the idea of the EtherBone (EB) core, which connects a Wishbone (WB) Ver. 4 Bus via a Gigabit Ethernet based network link to remote peripheral devices. EB acts as a transparent interconnect module towards attached WB Bus devices. Address information and data from one or more WB bus cycles is preceded with a descriptive header and encapsulated in a UDP/IP packet. Because of this standard compliance, EB is able to traverse Wide Area Networks and is therefore not bound to a geographic location. Due to the low level nature of the WB bus, EB provides a sound basis for remote hardware tools like a JTAG debugger, In-System-Programmer (ISP), boundary scan interface or logic analyser module. EB was developed in the scope of the White-Rabbit Timing Project (WR) at CERN and GSI/FAIR, which employs GigaBit Ethernet technology to communicate with memory mapped slave devices. WR will make use of EB as means to issue commands to its timing nodes and control connected accelerator hardware. (authors)

  7. Composite waste analysis system

    International Nuclear Information System (INIS)

    Wachter, J.R.; Hagan, R.C.; Bonner, C.A.; Malcom, J.E.; Camp, K.L.

    1993-01-01

    Nondestructive analysis (NDA) of radioactive waste forms an integral component of nuclear materials accountability programs and waste characterization acceptance criterion. However, waste measurements are often complicated by unknown isotopic compositions and the potential for concealment of special nuclear materials in a manner that is transparent to gamma-ray measurement instruments. To overcome these complications, a new NDA measurement system has been developed to assay special nuclear material in both transuranic and low level waste from the same measurement platform. The system incorporates a NaI detector and customized commercial software routines to measure small quantities of radioactive material in low level waste. Transuranic waste analysis is performed with a coaxial HPGE detector and uses upgraded PC-based segmented gamma scanner software to assay containers up to 55 gal. in volume. Gamma-Ray isotopics analysis of both waste forms is also performed with this detector. Finally, a small neutron counter using specialized software is attached to the measurement platform to satisfy safeguards concerns related to nuclear materials that are not sensed by the gamma-ray instruments. This report describes important features and capabilities of the system and presents a series of test measurements that are to be performed to define system parameters

  8. Actinide isotopic analysis systems

    International Nuclear Information System (INIS)

    Koenig, Z.M.; Ruhter, W.D.; Gunnink, R.

    1990-01-01

    This manual provides instructions and procedures for using the Lawrence Livermore National Laboratory's two-detector actinide isotope analysis system to measure plutonium samples with other possible actinides (including uranium, americium, and neptunium) by gamma-ray spectrometry. The computer program that controls the system and analyzes the gamma-ray spectral data is driven by a menu of one-, two-, or three-letter options chosen by the operator. Provided in this manual are descriptions of these options and their functions, plus detailed instructions (operator dialog) for choosing among the options. Also provided are general instructions for calibrating the actinide isotropic analysis system and for monitoring its performance. The inventory measurement of a sample's total plutonium and other actinides content is determined by two nondestructive measurements. One is a calorimetry measurement of the sample's heat or power output, and the other is a gamma-ray spectrometry measurement of its relative isotopic abundances. The isotopic measurements needed to interpret the observed calorimetric power measurement are the relative abundances of various plutonium and uranium isotopes and americium-241. The actinide analysis system carries out these measurements. 8 figs

  9. Comparison Study on Two Model-Based Adaptive Algorithms for SOC Estimation of Lithium-Ion Batteries in Electric Vehicles

    Directory of Open Access Journals (Sweden)

    Yong Tian

    2014-12-01

    Full Text Available State of charge (SOC estimation is essential to battery management systems in electric vehicles (EVs to ensure the safe operations of batteries and providing drivers with the remaining range of the EVs. A number of estimation algorithms have been developed to get an accurate SOC value because the SOC cannot be directly measured with sensors and is closely related to various factors, such as ambient temperature, current rate and battery aging. In this paper, two model-based adaptive algorithms, including the adaptive unscented Kalman filter (AUKF and adaptive slide mode observer (ASMO are applied and compared in terms of convergence behavior, tracking accuracy, computational cost and estimation robustness against parameter uncertainties of the battery model in SOC estimation. Two typical driving cycles, including the Dynamic Stress Test (DST and New European Driving Cycle (NEDC are applied to evaluate the performance of the two algorithms. Comparison results show that the AUKF has merits in convergence ability and tracking accuracy with an accurate battery model, while the ASMO has lower computational cost and better estimation robustness against parameter uncertainties of the battery model.

  10. Network systems security analysis

    Science.gov (United States)

    Yilmaz, Ä.°smail

    2015-05-01

    Network Systems Security Analysis has utmost importance in today's world. Many companies, like banks which give priority to data management, test their own data security systems with "Penetration Tests" by time to time. In this context, companies must also test their own network/server systems and take precautions, as the data security draws attention. Based on this idea, the study cyber-attacks are researched throughoutly and Penetration Test technics are examined. With these information on, classification is made for the cyber-attacks and later network systems' security is tested systematically. After the testing period, all data is reported and filed for future reference. Consequently, it is found out that human beings are the weakest circle of the chain and simple mistakes may unintentionally cause huge problems. Thus, it is clear that some precautions must be taken to avoid such threats like updating the security software.

  11. STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

    DEFF Research Database (Denmark)

    Brender, C; Nielsen, M; Kaltoft, K

    2001-01-01

    ) obtained from affected skin from a patient with mycosis fungoides (MF) and from peripheral blood from a patient with Sezary syndrome (SS). In contrast, constitutive SOCS-3 expression is not found in the leukemic Jurkat T-cell line, the MOLT-4 acute lymphoblastic leukemia cell line, and the monocytic......, it has been hypothesized that an aberrant SOCS expression plays a role in neoplastic transformation. This study reports on a constitutive SOCS-3 expression in cutaneous T-cell lymphoma (CTCL) cell lines. SOCS-3 protein is constitutively expressed in tumor cell lines (but not in nonmalignant T cells...... leukemic cell line U937. Expression of SOCS-3 coincides with a constitutive activation of STAT3 in CTCL tumor cells, and stable transfection of CTCL tumor cells with a dominant negative STAT3 strongly inhibits SOCS-3 expression, whereas transfection with wild-type STAT3 does not. Moreover, the reduced SOCS...

  12. Detecting small-scale spatial differences and temporal dynamics of soil organic carbon (SOC) stocks: a comparison between automatic chamber-derived C budgets and repeated soil inventories

    Science.gov (United States)

    Hoffmann, Mathias; Jurisch, Nicole; Garcia Alba, Juana; Albiac Borraz, Elisa; Schmidt, Marten; Huth, Vytas; Rogasik, Helmut; Rieckh, Helene; Verch, Gernot; Sommer, Michael; Augustin, Jürgen

    2017-04-01

    Carbon (C) sequestration in soils plays a key role in the global C cycle. It is therefore crucial to adequately monitor dynamics in soil organic carbon (ΔSOC) stocks when aiming to reveal underlying processes and potential drivers. However, small-scale spatial and temporal changes in SOC stocks, particularly pronounced on arable lands, are hard to assess. The main reasons for this are limitations of the well-established methods. On the one hand, repeated soil inventories, often used in long-term field trials, reveal spatial patterns and trends in ΔSOC but require a longer observation period and a sufficient number of repetitions. On the other hand, eddy covariance measurements of C fluxes towards a complete C budget of the soil-plant-atmosphere system may help to obtain temporal ΔSOC patterns but lack small-scale spatial resolution. To overcome these limitations, this study presents a reliable method to detect both short-term temporal as well as small-scale spatial dynamics of ΔSOC. Therefore, a combination of automatic chamber (AC) measurements of CO2 exchange and empirically modeled aboveground biomass development (NPPshoot) was used. To verify our method, results were compared with ΔSOC observed by soil resampling. AC measurements were performed from 2010 to 2014 under a silage maize/winter fodder rye/sorghum-Sudan grass hybrid/alfalfa crop rotation at a colluvial depression located in the hummocky ground moraine landscape of NE Germany. Widespread in large areas of the formerly glaciated Northern Hemisphere, this depression type is characterized by a variable groundwater level (GWL) and pronounced small-scale spatial heterogeneity in soil properties, such as SOC and nitrogen (Nt). After monitoring the initial stage during 2010, soil erosion was experimentally simulated by incorporating topsoil material from an eroded midslope soil into the plough layer of the colluvial depression. SOC stocks were quantified before and after soil manipulation and at the end

  13. Effects of land use change and management on SOC and soil quality in Mediterranean rangelands areas

    Science.gov (United States)

    Parras-Alcántara, Luis; Lozano-García, Beatriz; Requejo, Ana; Zornoza, Raúl

    2017-04-01

    INTRODUCTION Rangelands in the Iberian Peninsula occupy more than 90,000 km2. These rangelands were created from the former Mediterranean oak forests, mainly composed of holm oak and cork oak (Quercus ilex rotundifolia and Quercus suber), by clear-cutting shrubs, removing selected trees and cultivating. These man-made landscapes are called 'dehesas' in Spain and 'montados' in Portugal. Between 1955 and 1981, more than 5,000 km2 of dehesas was converted from pastureland to cultivated land. This process has been accelerated since 1986 owing to subsidies from the European Common Agricultural Policy (Parras-Alcántara et al., 2015a). The role that natural rangelands play in the global carbon cycle is extremely important, accounting for 10-30% of the world's total soil organic carbon (SOC), in addition, SOC concentration is closely related to soil quality and vegetation productivity (Brevik, 2012). Therefore, to study the land use and management changes is important, particularly in Mediterranean soils, as they are characterized by low organic carbon content, furthermore, the continuous use of ploughing for grain production is the principal cause of soil degradation. Therefore, land use decisions and management systems can increase or decrease SOC content and stock (Corral-Fernández et al., 2013; Parras-Alcántara et al., 2014, 2015a and 2015b; Parras-Alcántara and Lozano-García, 2014) MATERIAL AND METHODS A field study was conducted to determine the land use change (Mediterranean evergreen oak woodland to olive grove and cereal, all of them managed under conventional tillage and under conservationist practices) effects on SOC stocks and the soil quality (Stratification Ratio) in Los Pedroches valley, southern Spain. RESULTS Results for the present study indicate that management practices had little effect on SOC storage in dehesas. The stratification ratio was >2 both under conventional tillage and under organic farming, so, soils under dehesa had high quality

  14. Using SoC Online Correction Method Based on Parameter Identification to Optimize the Operation Range of NI-MH Battery for Electric Boat

    Directory of Open Access Journals (Sweden)

    Bumin Meng

    2018-03-01

    Full Text Available This paper discusses a design of a Battery Management System (BMS solution for extending the life of Nickel-Metal Hydride (NI-MH battery. Combined with application of electric boat, a State of Charge (SoC optimal operation range control method based on high precision energy metering and online SoC correction is proposed. Firstly, a power metering scheme is introduced to reduce the original energy measurement error. Secondly, by establishing a model based parameter identification method and combining with Extended Kalman Filter (EKF method, the estimation accuracy of SoC is guaranteed. Finally, SoC optimal operation range control method is presented to make battery running in the optimal range. After two years of operation, the battery managed by proposed method has much better status, compared to batteries that use AH integral method and fixed SoC operating range. Considering the SoC estimation of NI-MH battery is more difficult becausing special electrical characteristics, proposed method also would have a very good reference value for other types of battery management.

  15. Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain

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    Mignot Emmanuel

    2007-05-01

    Full Text Available Abstract Background Narcolepsy causes dramatic behavioral alterations in both humans and dogs, with excessive sleepiness and cataplexy triggered by emotional stimuli. Deficiencies in the hypocretin system are well established as the origin of the condition; both from studies in humans who lack the hypocretin ligand (HCRT and in dogs with a mutation in hypocretin receptor 2 (HCRTR2. However, little is known about molecular alterations downstream of the hypocretin signals. Results By using microarray technology we have screened the expression of 29760 genes in the brains of Doberman dogs with a heritable form of narcolepsy (homozygous for the canarc-1 [HCRTR-2-2] mutation, and their unaffected heterozygous siblings. We identified two neuropeptide precursor molecules, Tachykinin precursor 1 (TAC1 and Proenkephalin (PENK, that together with Suppressor of cytokine signaling 2 (SOCS2, showed reduced expression in narcoleptic brains. The difference was particularly pronounced in the amygdala, where mRNA levels of PENK were 6.2 fold lower in narcoleptic dogs than in heterozygous siblings, and TAC1 and SOCS2 showed 4.4 fold and 2.8 fold decrease in expression, respectively. The results obtained from microarray experiments were confirmed by real-time RT-PCR. Interestingly, it was previously shown that a single dose of amphetamine-like stimulants able to increase wakefulness in the dogs, also produce an increase in the expression of both TAC1 and PENK in mice. Conclusion These results suggest that TAC1, PENK and SOCS2 might be intimately connected with the excessive daytime sleepiness not only in dogs, but also in other species, possibly including humans.

  16. Measurement of the complete core plasma flow across the LOC-SOC transition at ASDEX Upgrade

    Science.gov (United States)

    Lebschy, A.; McDermott, R. M.; Angioni, C.; Geiger, B.; Prisiazhniuk, D.; Cavedon, M.; Conway, G. D.; Dux, R.; Dunne, M. G.; Kappatou, A.; Pütterich, T.; Stroth, U.; Viezzer, E.; the ASDEX Upgrade Team

    2018-02-01

    A newly installed core charge exchange recombination spectroscopy (CXRS) diagnostic at ASDEX Upgrade (AUG) enables the evaluation of the core poloidal rotation (upol ) through the inboard-outboard asymmetry of the toroidal rotation with an accuracy of 0.5 to 1 km s-1 . Using this technique, the total plasma flow has been measured in Ohmic L-mode plasmas across the transition from the linear to saturated ohmic confinement (LOC-SOC) regimes. The core poloidal rotation of the plasma around mid-radius is found to be always in the ion diamagnetic direction, in disagreement with neoclassical (NC) predictions. The edge rotation is found to be electron-directed and consistent with NC codes. This measurement provides as well the missing ingredient to evaluate the core E×B velocity (uE×B ) from data only, which can then be compared to measurements of the perpendicular velocity of the turbulent fluctuations (u\\perp ) to gain information on the turbulent phase velocity (vph ). The non neoclassical upol from CXRS leads to good agreement between uE×B and u\\perp indicating that vph is small and at similar values as found with gyrokinetic simulations. Moreover, the data shows a shift of vph in the ion-diamagnetic direction at the edge after the transition from LOC to SOC consistent with a change in the dominant turbulence regime. The upgrade of the core CXRS system provides as well a deeper insight into the intrinsic rotation. This paper shows that the reversal of the core toroidal rotation occurs clearly after the LOC-SOC transition and concomitant with the peaking of the electron density.

  17. Prediction of SOC content by Vis-NIR spectroscopy at European scale using a modified local PLS algorithm

    Science.gov (United States)

    Nocita, M.; Stevens, A.; Toth, G.; van Wesemael, B.; Montanarella, L.

    2012-12-01

    In the context of global environmental change, the estimation of carbon fluxes between soils and the atmosphere has been the object of a growing number of studies. This has been motivated notably by the possibility to sequester CO2 into soils by increasing the soil organic carbon (SOC) stocks and by the role of SOC in maintaining soil quality. Spatial variability of SOC masks its slow accumulation or depletion, and the sampling density required to detect a change in SOC content is often very high and thus very expensive and labour intensive. Visible near infrared diffuse reflectance spectroscopy (Vis-NIR DRS) has been shown to be a fast, cheap and efficient tool for the prediction of SOC at fine scales. However, when applied to regional or country scales, Vis-NIR DRS did not provide sufficient accuracy as an alternative to standard laboratory soil analysis for SOC monitoring. Under the framework of Land Use/Cover Area Frame Statistical Survey (LUCAS) project of the European Commission's Joint Research Centre (JRC), about 20,000 samples were collected all over European Union. Soil samples were analyzed for several physical and chemical parameters, and scanned with a Vis-NIR spectrometer in the same laboratory. The scope of our research was to predict SOC content at European scale using LUCAS spectral library. We implemented a modified local partial least square regression (l-PLS) including, in addition to spectral distance, other potentially useful covariates (geography, texture, etc.) to select for each unknown sample a group of predicting neighbours. The dataset was split in mineral soils under cropland, mineral soils under grassland, mineral soils under woodland, and organic soils due to the extremely diverse spectral response of the four classes. Four every class training (70%) and test (30%) sets were created to calibrate and validate the SOC prediction models. The results showed very good prediction ability for mineral soils under cropland and mineral soils

  18. Straw incorporation increases crop yield and soil organic carbon sequestration but varies under different natural conditions and farming practices in China: a system analysis

    Directory of Open Access Journals (Sweden)

    X. Han

    2018-04-01

    Full Text Available Loss of soil organic carbon (SOC from agricultural soils is a key indicator of soil degradation associated with reductions in net primary productivity in crop production systems worldwide. Technically simple and locally appropriate solutions are required for farmers to increase SOC and to improve cropland management. In the last 30 years, straw incorporation (SI has gradually been implemented across China in the context of agricultural intensification and rural livelihood improvement. A meta-analysis of data published before the end of 2016 was undertaken to investigate the effects of SI on crop production and SOC sequestration. The results of 68 experimental studies throughout China in different edaphic conditions, climate regions and farming regimes were analyzed. Compared with straw removal (SR, SI significantly sequestered SOC (0–20 cm depth at the rate of 0.35 (95 % CI, 0.31–0.40 Mg C ha−1 yr−1, increased crop grain yield by 13.4 % (9.3–18.4 % and had a conversion efficiency of the incorporated straw C of 16 % ± 2 % across China. The combined SI at the rate of 3 Mg C ha−1 yr−1 with mineral fertilizer of 200–400 kg N ha−1 yr−1 was demonstrated to be the best farming practice, where crop yield increased by 32.7 % (17.9–56.4 % and SOC sequestrated by the rate of 0.85 (0.54–1.15 Mg C ha−1 yr−1. SI achieved a higher SOC sequestration rate and crop yield increment when applied to clay soils under high cropping intensities, and in areas such as northeast China where the soil is being degraded. The SOC responses were highest in the initial starting phase of SI, then subsequently declined and finally became negligible after 28–62 years. However, crop yield responses were initially low and then increased, reaching their highest level at 11–15 years after SI. Overall, our study confirmed that SI created a positive feedback loop of SOC enhancement together with

  19. Straw incorporation increases crop yield and soil organic carbon sequestration but varies under different natural conditions and farming practices in China: a system analysis

    Science.gov (United States)

    Han, Xiao; Xu, Cong; Dungait, Jennifer A. J.; Bol, Roland; Wang, Xiaojie; Wu, Wenliang; Meng, Fanqiao

    2018-04-01

    Loss of soil organic carbon (SOC) from agricultural soils is a key indicator of soil degradation associated with reductions in net primary productivity in crop production systems worldwide. Technically simple and locally appropriate solutions are required for farmers to increase SOC and to improve cropland management. In the last 30 years, straw incorporation (SI) has gradually been implemented across China in the context of agricultural intensification and rural livelihood improvement. A meta-analysis of data published before the end of 2016 was undertaken to investigate the effects of SI on crop production and SOC sequestration. The results of 68 experimental studies throughout China in different edaphic conditions, climate regions and farming regimes were analyzed. Compared with straw removal (SR), SI significantly sequestered SOC (0-20 cm depth) at the rate of 0.35 (95 % CI, 0.31-0.40) Mg C ha-1 yr-1, increased crop grain yield by 13.4 % (9.3-18.4 %) and had a conversion efficiency of the incorporated straw C of 16 % ± 2 % across China. The combined SI at the rate of 3 Mg C ha-1 yr-1 with mineral fertilizer of 200-400 kg N ha-1 yr-1 was demonstrated to be the best farming practice, where crop yield increased by 32.7 % (17.9-56.4 %) and SOC sequestrated by the rate of 0.85 (0.54-1.15) Mg C ha-1 yr-1. SI achieved a higher SOC sequestration rate and crop yield increment when applied to clay soils under high cropping intensities, and in areas such as northeast China where the soil is being degraded. The SOC responses were highest in the initial starting phase of SI, then subsequently declined and finally became negligible after 28-62 years. However, crop yield responses were initially low and then increased, reaching their highest level at 11-15 years after SI. Overall, our study confirmed that SI created a positive feedback loop of SOC enhancement together with increased crop production, and this is of great practical importance to straw management as agriculture

  20. Perception SoC Based on an Ultrasonic Array of Sensors: Efficient DSP Core Implementation and Subsequent Experimental Results

    Directory of Open Access Journals (Sweden)

    A. Haidar

    2005-05-01

    Full Text Available We are concerned with the design, implementation, and validation of a perception SoC based on an ultrasonic array of sensors. The proposed SoC is dedicated to ultrasonic echography applications. A rapid prototyping platform is used to implement and validate the new architecture of the digital signal processing (DSP core. The proposed DSP core efficiently integrates all of the necessary ultrasonic B-mode processing modules. It includes digital beamforming, quadrature demodulation of RF signals, digital filtering, and envelope detection of the received signals. This system handles 128 scan lines and 6400 samples per scan line with a 90° angle of view span. The design uses a minimum size lookup memory to store the initial scan information. Rapid prototyping using an ARM/FPGA combination is used to validate the operation of the described system. This system offers significant advantages of portability and a rapid time to market.

  1. Perception SoC Based on an Ultrasonic Array of Sensors: Efficient DSP Core Implementation and Subsequent Experimental Results

    Science.gov (United States)

    Kassem, A.; Sawan, M.; Boukadoum, M.; Haidar, A.

    2005-12-01

    We are concerned with the design, implementation, and validation of a perception SoC based on an ultrasonic array of sensors. The proposed SoC is dedicated to ultrasonic echography applications. A rapid prototyping platform is used to implement and validate the new architecture of the digital signal processing (DSP) core. The proposed DSP core efficiently integrates all of the necessary ultrasonic B-mode processing modules. It includes digital beamforming, quadrature demodulation of RF signals, digital filtering, and envelope detection of the received signals. This system handles 128 scan lines and 6400 samples per scan line with a[InlineEquation not available: see fulltext.] angle of view span. The design uses a minimum size lookup memory to store the initial scan information. Rapid prototyping using an ARM/FPGA combination is used to validate the operation of the described system. This system offers significant advantages of portability and a rapid time to market.

  2. The Impact of Strong Cathodic Polarization on SOC Electrolyte Materials

    DEFF Research Database (Denmark)

    Kreka, Kosova; Hansen, Karin Vels; Jacobsen, Torben

    2016-01-01

    One of the most promising reversible energy conversion/storage technologies is that of Solid Oxide Fuel/Electrolysis Cells (SOFC/SOEC, collectively termed SOC). Long term durability is typically required for such devises to become economically feasible, hence considerable amount of work has...... of impurities at the grain boundaries, electrode poisoning, delamination or cracks of the electrolyte etc., have been observed in cells operated at such conditions, lowering the lifetime of the cell1,2. High polarizations are observed at the electrolyte/cathode interface of an electrolysis cell operated at high...... current density. In case of a cell voltage above 1.6 V, p-type and n-type electronic conductivity are often observed at the anode and cathode respectively3. Hence, a considerable part of the current is lost as leakage through the electrolyte, thus lowering the efficiency of the cell considerably....

  3. SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro

    Directory of Open Access Journals (Sweden)

    Zhang Qingfu

    2008-05-01

    Full Text Available Abstract Background Suppressor of cytokine signaling 3 (SOCS3 is considered to inhibit cytokine responses and play a negative role in migration of various cells. Proline-rich tyrosine kinase 2 (PYK2 is a non-receptor kinase and has been found crucial to cell motility. However, little is known about whether SOCS3 could regulate PYK2 pro-migratory function in lung cancer. Methods The methylation status of SOCS3 was investigated in HBE and A549 cell lines by methylation-specific PCR. A549 cells were either treated with a demethylation agent 5-aza-2'-deoxycytidine or transfected with three SOCS3 mutants with various functional domains deleted. Besides, cells were pretreated with a proteasome inhibitor β-lactacystin where indicated. The effects of SOCS3 up-regulation on PYK2 expression, PYK2 and ERK1/2 phosphorylations were assessed by western blot using indicated antibodies. RT-PCR was used to estimate PYK2 mRNA levels. Transwell experiments were performed to evaluate cell migration. Results SOCS3 expression was found impaired in A549 cells and higher PYK2 activity was correlated with enhanced cell migration. We identified that SOCS3 was aberrantly methylated in the exon 2, and 5-aza-2'-deoxycytidine restored SOCS3 expression. Reactivation of SOCS3 attenuated PYK2 expression and phosphorylation, cell migration was inhibited as well. Transfection studies indicated that exogenous SOCS3 interacted with PYK2, and both the Src homology 2 (SH2 and the kinase inhibitory region (KIR domains of SOCS3 contributed to PYK2 binding. Furthermore, SOCS3 was found to inhibit PYK2-associated ERK1/2 activity in A549 cells. SOCS3 possibly promoted degradation of PYK2 in a SOCS-box-dependent manner and interfered with PYK2-related signaling events, such as cell migration. Conclusion These data indicate that SOCS3 negatively regulates cell motility and decreased SOCS3 induced by methylation may confer a migration advantage to A549 cells. These results also suggest a

  4. A new circuit for at-speed scan SoC testing

    International Nuclear Information System (INIS)

    Lin Wei; Shi Wenlong

    2013-01-01

    It is very important to detect transition-delay faults and stuck-at faults in system on chip (SoC) under 90 nm processing technology, and the transition-delay faults can only be detected by using an at-speed testing method. In this paper, an on-chip clock (OCC) controller with a bypass function based on an internal phase-locked loop is designed to test faults in SoC. Furthermore, a clock chain logic which can eliminate the metastable state is realized to generate an enable signal for the OCC controller, and then, the test pattern is generated by automatic test pattern generation (ATPG) tools. Next, the scan test pattern is simulated by using the Synopsys tool and the correctness of the design is verified. The result shows that the design of an at-speed scan test in this paper is highly efficient for detecting timing-related defects. Finally, the 89.29% transition-delay fault coverage and the 94.50% stuck-at fault coverage are achieved, and it is successfully applied to an integrated circuit design. (semiconductor integrated circuits)

  5. Defective interleukin-4/Stat6 activity correlates with increased constitutive expression of negative regulators SOCS-3, SOCS-7, and CISH in colon cancer cells.

    Science.gov (United States)

    Liu, Xiao Hong; Xu, Shuang Bing; Yuan, Jia; Li, Ben Hui; Zhang, Yan; Yuan, Qin; Li, Pin Dong; Li, Feng; Zhang, Wen Jie

    2009-12-01

    Interleukin-4 (IL-4)-induced Stat6 activities (phenotypes) vary among human cancer cells, of which the HT-29 cell line carries an active Stat6(high) phenotype, while Caco-2 carries a defective Stat6(null) phenotype, respectively. Cancer cells with Stat6(high) show resistance to apoptosis and exaggerated metastasis, suggesting the clinical significance of Stat6 phenotypes. We previously showed that Stat6(high) HT-29 cells exhibited low constitutive expression of Stat6-negative regulators SOCS-1 and SHP-1 because of gene hypermethylation. This study further examined the constitutive expression of other closely related SOCS family numbers including SOCS-3, SOCS-5, SOCS-7, and CISH using RT-PCR. Similar to SOCS-1 and SHP-1, Stat6(high) HT-29 cells expressed low constitutive mRNA of SOCS-3, SOCS-7, and CISH than Stat6(null) Caco-2 cells. Interestingly, DNA demethylation using 5-aza-2'-deoxycytidine in HT-29 cells up-regulated mRNA expression of the above genes, indicating a hypermethylation status, which was confirmed by methylation-specific sequencing in selected SOCS-3 gene. Furthermore, defective Stat6(null) Caco-2 exhibited impaired phosphorylation of Stat6 after IL-4 stimulation by flow cytometry, in keeping with the notion of an over-performed negative regulation. The findings that IL-4/Stat6 phenotypes show differential expression of multiple negative regulators suggest a model that a collective force of powerful negative regulators, directly and indirectly, acts on Stat6 activation, which may result in differential Stat6 phenotypes.

  6. Detecting small-scale spatial heterogeneity and temporal dynamics of soil organic carbon (SOC) stocks: a comparison between automatic chamber-derived C budgets and repeated soil inventories

    Science.gov (United States)

    Hoffmann, Mathias; Jurisch, Nicole; Garcia Alba, Juana; Albiac Borraz, Elisa; Schmidt, Marten; Huth, Vytas; Rogasik, Helmut; Rieckh, Helene; Verch, Gernot; Sommer, Michael; Augustin, Jürgen

    2017-03-01

    Carbon (C) sequestration in soils plays a key role in the global C cycle. It is therefore crucial to adequately monitor dynamics in soil organic carbon (ΔSOC) stocks when aiming to reveal underlying processes and potential drivers. However, small-scale spatial (10-30 m) and temporal changes in SOC stocks, particularly pronounced in arable lands, are hard to assess. The main reasons for this are limitations of the well-established methods. On the one hand, repeated soil inventories, often used in long-term field trials, reveal spatial patterns and trends in ΔSOC but require a longer observation period and a sufficient number of repetitions. On the other hand, eddy covariance measurements of C fluxes towards a complete C budget of the soil-plant-atmosphere system may help to obtain temporal ΔSOC patterns but lack small-scale spatial resolution. To overcome these limitations, this study presents a reliable method to detect both short-term temporal dynamics as well as small-scale spatial differences of ΔSOC using measurements of the net ecosystem carbon balance (NECB) as a proxy. To estimate the NECB, a combination of automatic chamber (AC) measurements of CO2 exchange and empirically modeled aboveground biomass development (NPPshoot) were used. To verify our method, results were compared with ΔSOC observed by soil resampling. Soil resampling and AC measurements were performed from 2010 to 2014 at a colluvial depression located in the hummocky ground moraine landscape of northeastern Germany. The measurement site is characterized by a variable groundwater level (GWL) and pronounced small-scale spatial heterogeneity regarding SOC and nitrogen (Nt) stocks. Tendencies and magnitude of ΔSOC values derived by AC measurements and repeated soil inventories corresponded well. The period of maximum plant growth was identified as being most important for the development of spatial differences in annual ΔSOC. Hence, we were able to confirm that AC-based C budgets are able

  7. SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

    DEFF Research Database (Denmark)

    Brender, Christine; Columbus, Ruth; Metcalf, Donald

    2004-01-01

    the importance of SOCS5 in T helper cell responses. Unexpectedly, SOCS5-deficient CD4 T cells showed no abnormalities in Th1/Th2 differentiation and Socs5(-/-) mice showed normal resistance to infection with Leishmania major. Therefore, although SOCS5 is expressed in primary B and T cells, it appears...

  8. Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.

    Science.gov (United States)

    Kedzierski, Lukasz; Tate, Michelle D; Hsu, Alan C; Kolesnik, Tatiana B; Linossi, Edmond M; Dagley, Laura; Dong, Zhaoguang; Freeman, Sarah; Infusini, Giuseppe; Starkey, Malcolm R; Bird, Nicola L; Chatfield, Simon M; Babon, Jeffrey J; Huntington, Nicholas; Belz, Gabrielle; Webb, Andrew; Wark, Peter Ab; Nicola, Nicos A; Xu, Jianqing; Kedzierska, Katherine; Hansbro, Philip M; Nicholson, Sandra E

    2017-02-14

    Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. Here we show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). Socs5 -deficient mice exhibit heightened disease severity, with increased viral titres and weight loss. Socs5 levels were differentially regulated in response to distinct influenza viruses (H1N1, H3N2, H5N1 and H11N9) and were reduced in primary epithelial cells from COPD patients, again correlating with increased susceptibility to influenza. Importantly, restoration of SOCS5 levels restricted influenza virus infection, suggesting that manipulating SOCS5 expression and/or SOCS5 targets might be a novel therapeutic approach to influenza.

  9. Estimation of power lithium-ion battery SOC based on fuzzy optimal decision

    Science.gov (United States)

    He, Dongmei; Hou, Enguang; Qiao, Xin; Liu, Guangmin

    2018-06-01

    In order to improve vehicle performance and safety, need to accurately estimate the power lithium battery state of charge (SOC), analyzing the common SOC estimation methods, according to the characteristics open circuit voltage and Kalman filter algorithm, using T - S fuzzy model, established a lithium battery SOC estimation method based on the fuzzy optimal decision. Simulation results show that the battery model accuracy can be improved.

  10. Medicago truncatula SOC1 Genes Are Up-regulated by Environmental Cues That Promote Flowering

    Directory of Open Access Journals (Sweden)

    Jared B. Fudge

    2018-04-01

    Full Text Available Like Arabidopsis thaliana, the flowering of the legume Medicago truncatula is promoted by long day (LD photoperiod and vernalization. However, there are differences in the molecular mechanisms involved, with orthologs of two key Arabidopsis thaliana regulators, FLOWERING LOCUS C (FLC and CONSTANS (CO, being absent or not having a role in flowering time function in Medicago. In Arabidopsis, the MADS-box transcription factor gene, SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (AtSOC1, plays a key role in integrating the photoperiodic and vernalization pathways. In this study, we set out to investigate whether the Medicago SOC1 genes play a role in regulating flowering time. Three Medicago SOC1 genes were identified and characterized (MtSOC1a–MtSOC1c. All three MtSOC1 genes, when heterologously expressed, were able to promote earlier flowering of the late-flowering Arabidopsis soc1-2 mutant. The three MtSOC1 genes have different patterns of expression. However, consistent with a potential role in flowering time regulation, all three MtSOC1 genes are expressed in the shoot apex and are up-regulated in the shoot apex of plants in response to LD photoperiods and vernalization. The up-regulation of MtSOC1 genes was reduced in Medicago fta1-1 mutants, indicating that they are downstream of MtFTa1. Insertion mutant alleles of Medicago soc1b do not flower late, suggestive of functional redundancy among Medicago SOC1 genes in promoting flowering.

  11. Logical analysis of biological systems

    DEFF Research Database (Denmark)

    Mardare, Radu Iulian

    2005-01-01

    R. Mardare, Logical analysis of biological systems. Fundamenta Informaticae, N 64:271-285, 2005.......R. Mardare, Logical analysis of biological systems. Fundamenta Informaticae, N 64:271-285, 2005....

  12. Purification of SOCS (Suppressor of Cytokine Signaling) SH2 Domains for Structural and Functional Studies.

    Science.gov (United States)

    Liau, Nicholas P D; Laktyushin, Artem; Babon, Jeffrey J

    2017-01-01

    Src Homology 2 (SH2) domains are protein domains which have a high binding affinity for specific amino acid sequences containing a phosphorylated tyrosine residue. The Suppressors of Cytokine Signaling (SOCS) proteins use an SH2 domain to bind to components of certain cytokine signaling pathways to downregulate the signaling cascade. The recombinantly produced SH2 domains of various SOCS proteins have been used to undertake structural and functional studies elucidating the method of how such targeting occurs. Here, we describe the protocol for the recombinant production and purification of SOCS SH2 domains, with an emphasis on SOCS3.

  13. IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever

    Directory of Open Access Journals (Sweden)

    Lilian Karem Flores-Mendoza

    2017-01-01

    Full Text Available Background. Cytokines play important roles in the physiopathology of dengue infection; therefore, the suppressors of cytokine signaling (socs that control the type and timing of cytokine functions could be involved in the origin of immune alterations in dengue. Objective. To explore the association of cytokine and socs levels with disease severity in dengue patients. Methods. Blood samples of 48 patients with confirmed dengue infection were analyzed. Amounts of interleukins IL-2, IL-4, IL-6, and IL-10, interferon- (IFN- γ, and tumor necrosis factor- (TNF- α were quantified by flow cytometry, and the relative expression of socs1 and socs3 mRNA was quantified by real-time RT-PCR. Results. Increased levels of IL-10 and socs3 and lower expression of socs1 were found in patients with dengue hemorrhagic fever (DHF with respect to those with dengue fever (DF (p199.8-fold, socs1 (134 pg/ml have the highest sensitivity and specificity to discriminate between DF and DHF. Conclusion. Simultaneous changes in IL-10 and socs1/socs3 could be used as prognostic biomarkers of dengue severity.

  14. Favorable prognostic value of SOCS2 and IGF-I in breast cancer

    International Nuclear Information System (INIS)

    Haffner, Michael C; Petridou, Barbara; Peyrat, Jean Phillipe; Révillion, Françoise; Müller-Holzner, Elisabeth; Daxenbichler, Günter; Marth, Christian; Doppler, Wolfgang

    2007-01-01

    Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and para/autocrine growth and differentiation factor in mammary gland development. Whereas high levels of circulating IGF-I have been associated with increased cancer risk, the role of autocrine acting IGF-I is less clear. The present study is aimed to elucidate the clinicopathological features associated with SOCS1, SOCS2, SOCS3, CIS and IGF-I expression in breast cancer. We determined the mRNA expression levels of SOCS1, SOCS2, SOCS3, CIS and IGF-I in 89 primary breast cancers by reverse transcriptase PCR. SOCS2 protein expression was further evaluated by immuno-blot and immunohistochemistry. SOCS2 expression inversely correlated with histopathological grade and ER positive tumors exhibited higher SOCS2 levels. Patients with high SOCS2 expression lived significantly longer (108.7 vs. 77.7 months; P = 0.015) and high SOCS2 expression proved to be an independent predictor for good prognosis (HR = 0.45, 95% CI 0.23 – 0.91, P = 0.026). In analogy to SOCS2, high IGF-I expression was an independent predictor for good prognosis in the entire patient cohort. In the subgroup of patients with lymph-node negative disease, high IGF-I was a strong predictor for favorable outcome in terms of overall survival and relapse free survival (HR = 0.075, 95% CI 0.014 – 0.388, P = 0.002). This is the first report on the favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. Furthermore a strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients. Our results suggest that high expression of the STAT5 target genes SOCS2 and IGF-I is a feature of differentiated and less malignant tumors

  15. Favorable prognostic value of SOCS2 and IGF-I in breast cancer

    Directory of Open Access Journals (Sweden)

    Daxenbichler Günter

    2007-07-01

    Full Text Available Abstract Background Suppressor of cytokine signaling (SOCS proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and para/autocrine growth and differentiation factor in mammary gland development. Whereas high levels of circulating IGF-I have been associated with increased cancer risk, the role of autocrine acting IGF-I is less clear. The present study is aimed to elucidate the clinicopathological features associated with SOCS1, SOCS2, SOCS3, CIS and IGF-I expression in breast cancer. Methods We determined the mRNA expression levels of SOCS1, SOCS2, SOCS3, CIS and IGF-I in 89 primary breast cancers by reverse transcriptase PCR. SOCS2 protein expression was further evaluated by immuno-blot and immunohistochemistry. Results SOCS2 expression inversely correlated with histopathological grade and ER positive tumors exhibited higher SOCS2 levels. Patients with high SOCS2 expression lived significantly longer (108.7 vs. 77.7 months; P = 0.015 and high SOCS2 expression proved to be an independent predictor for good prognosis (HR = 0.45, 95% CI 0.23 – 0.91, P = 0.026. In analogy to SOCS2, high IGF-I expression was an independent predictor for good prognosis in the entire patient cohort. In the subgroup of patients with lymph-node negative disease, high IGF-I was a strong predictor for favorable outcome in terms of overall survival and relapse free survival (HR = 0.075, 95% CI 0.014 – 0.388, P = 0.002. Conclusion This is the first report on the favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. Furthermore a strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients. Our results suggest that high expression of the STAT5 target genes SOCS2 and IGF

  16. An Overview and Comparison of Online Implementable SOC Estimation Methods for Lithium-ion Battery

    DEFF Research Database (Denmark)

    Meng, Jinhao; Ricco, Mattia; Luo, Guangzhao

    2018-01-01

    . Many SOC estimation methods have been proposed in the literature. However, only a few of them consider the real-time applicability. This paper reviews recently proposed online SOC estimation methods and classifies them into five categories. Their principal features are illustrated, and the main pros...... and cons are provided. The SOC estimation methods are compared and discussed in terms of accuracy, robustness, and computation burden. Afterward, as the most popular type of model based SOC estimation algorithms, seven nonlinear filters existing in literature are compared in terms of their accuracy...

  17. Fish Suppressors of Cytokine Signaling (SOCS): Gene Discovery, Modulation of Expression and Function

    Science.gov (United States)

    Wang, Tiehui; Gorgoglione, Bartolomeo; Maehr, Tanja; Holland, Jason W.; Vecino, Jose L. González; Wadsworth, Simon; Secombes, Christopher J.

    2011-01-01

    The intracellular suppressors of cytokine signaling (SOCS) family members, including CISH and SOCS1 to 7 in mammals, are important regulators of cytokine signaling pathways. So far, the orthologues of all the eight mammalian SOCS members have been identified in fish, with several of them having multiple copies. Whilst fish CISH, SOCS3, and SOCS5 paralogues are possibly the result of the fish-specific whole genome duplication event, gene duplication or lineage-specific genome duplication may also contribute to some paralogues, as with the three trout SOCS2s and three zebrafish SOCS5s. Fish SOCS genes are broadly expressed and also show species-specific expression patterns. They can be upregulated by cytokines, such as IFN-γ, TNF-α, IL-1β, IL-6, and IL-21, by immune stimulants such as LPS, poly I:C, and PMA, as well as by viral, bacterial, and parasitic infections in member- and species-dependent manners. Initial functional studies demonstrate conserved mechanisms of fish SOCS action via JAK/STAT pathways. PMID:22203897

  18. Corrosion potential analysis system

    Science.gov (United States)

    Kiefer, Karl F.

    1998-03-01

    Many cities in the northeastern U.S. transport electrical power from place to place via underground cables, which utilize voltages from 68 kv to 348 kv. These cables are placed in seamless steel pipe to protect the conductors. These buried pipe-type-cables (PTCs) are carefully designed and constantly pressurized with transformer oil to prevent any possible contamination. A protective coating placed on the outside diameter of the pipe during manufacture protects the steel pipe from the soil environment. Notwithstanding the protection mechanisms available, the pipes remain vulnerable to electrochemical corrosion processes. If undetected, corrosion can cause the pipes to leak transformer oil into the environment. These leaks can assume serious proportions due to the constant pressure on the inside of the pipe. A need exists for a detection system that can dynamically monitor the corrosive potential on the length of the pipe and dynamically adjust cathodic protection to counter local and global changes in the cathodic environment surrounding the pipes. The northeastern United States contains approximately 1000 miles of this pipe. This milage is critical to the transportation and distribution of power. So critical, that each of the pipe runs has a redundant double running parallel to it. Invocon, Inc. proposed and tested a technically unique and cost effective solution to detect critical corrosion potential and to communicate that information to a central data collection and analysis location. Invocon's solution utilizes the steel of the casing pipe as a communication medium. Each data gathering station on the pipe can act as a relay for information gathered elsewhere on the pipe. These stations must have 'smart' network configuration algorithms that constantly test various communication paths and determine the best and most power efficient route through which information should flow. Each network station also performs data acquisition and analysis tasks that ultimately

  19. Neighborhood-resources for the development of a strong SOC and the importance of understanding why and how resources work: a grounded theory approach.

    Science.gov (United States)

    Maass, Ruca; Lindström, Bengt; Lillefjell, Monica

    2017-09-12

    Providing individuals with psychosocial resources such as sense of coherence (SOC) seems a beneficial strategy for health promotion in the neighborhood. In order to become a supporting theory for health promotion, Salutogenesis should renew its focus on resources for health, and explore how the development of a strong SOC can be facilitated. Relevant issues were explored using a Grounded Theory- approach. Three focus-group-sessions and three in-depth interviews were conducted with strategically sampled participants. The transcripts of the focus groups were initially analyzed line-by-line to ensure that insights emerged from the data. We then applied focused and systemic analyses to achieve axial coding, and to include insights into how social interactions during focus groups may reveal social processes in real-life-neighborhoods. The data from the in-depth interviews were used to validate and fill emerging categories, as well as to ensure data-saturation. Findings indicate the importance of repeated experiences with resources and every-day-challenges to develop a strong SOC. Active engagement with resources is a favorable condition for significant experiences, which enhance the internalization of resources. Core experiences are characterized by a re-organization of resources. Participation in intellectual meaning-making through equal power dialogue seems to broaden perspectives and promote the strengthening of SOC. A strong SOC can also be described as a deeper understanding of how and why resources work, which allows for a more flexible use of resources, including replacing missing resources. A new understanding of SOC as an intuitive understanding of how, why and under which circumstances resources work, as well as a new focus on everyday life and repeated experiences might facilitate new approaches to a purposeful strengthening of SOC through the planning and implementation of public measures.

  20. 3D Embedded Reconfigurable SoC for Expediting Magnetometric Space Missions

    Science.gov (United States)

    Dekoulis, George

    2016-07-01

    This paper describes the development of a state-of-the-art three-dimensional embedded reconfigurable System-on-Chip (SoC) for accelerating the design of future magnetometric space missions. This involves measurements of planetary magnetic fields or measurements of heliospheric physics events' signatures superimposed on the aggregate measurements of the stronger planetary fields. The functionality of the embedded core is fully customizable, therefore, its operation is independent of the magnetic sensor being used. Standard calibration procedures still apply for setting the magnetometer measurements to the desired initial state and removing any seriatim interference inferred by the adjacent environment. The system acts as a pathfinder for future high-resolution heliospheric space missions.

  1. Effect of SOCS1 overexpression on RPE cell activation by proinflammatory cytokines.

    Science.gov (United States)

    Bazewicz, Magdalena; Draganova, Dafina; Makhoul, Maya; Chtarto, Abdel; Elmaleh, Valerie; Tenenbaum, Liliane; Caspers, Laure; Bruyns, Catherine; Willermain, François

    2016-09-06

    The purpose of this study was to investigate the in vitro effect of Suppressor Of Cytokine Signaling 1 (SOCS1) overexpression in retinal pigment epithelium (RPE) cells on their activation by pro-inflammatory cytokines IFNγ, TNFα and IL-17. Retinal pigment epithelium cells (ARPE-19) were stably transfected with the control plasmid pIRES2-AcGFP1 or the plasmid pSOCS1-IRES2-AcGFP1. They were stimulated by IFNγ (150ng/ml), TNFα (30ng/ml) or IL-17 (100ng/ml). The levels of SOCS1 mRNA were measured by real-time PCR. Signal Transducer and Activator of Transcription 1 (STAT1) phosphorylation and IκBα expression were analysed by western Blot (WB). IL-8 secretion was analysed by ELISA and expression of MHCII molecules and ICAM-1/CD54 by flow cytometry. Our data show that SOCS1 mRNA overexpression in RPE cells prevents IFNγ-induced SOCS1 mRNA increase and IFNγ-mediated STAT1 phosphorylation. Moreover, SOCS1 overexpression in RPE cells inhibits IFNγ-induced decrease of IL-8 secretion and prevents IFNγ-induced MHC II and ICAM1/CD54 upregulation. However, SOCS1 overexpression does not affect TNFα-induced IκBα degradation nor block TNFα-induced or IL-17-induced IL-8 secretion. On the contrary, IL-17-induced secretion is increased by SOCS1 overexpression. In conclusion, SOCS1 overexpression in RPE cells inhibits some IFNγ-mediated responses that lead to uveitis development. This notion raises the possibility that SOCS1 overexpression could be a novel target for treating non-infectious uveitis. However, some proinflammatory effects of TNFα and IL-17 stimulation on RPE are not blocked by SOCS1 overexpression. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  2. Implementation of QoSS (Quality-of-Security Service) for NoC-Based SoC Protection

    Science.gov (United States)

    Sepúlveda, Johanna; Pires, Ricardo; Strum, Marius; Chau, Wang Jiang

    Many of the current electronic systems embedded in a SoC (System-on-Chip) are used to capture, store, manipulate and access critical data, as well as to perform other key functions. In such a scenario, security is considered as an important issue. The Network-on-chip (NoC), as the foreseen communication structure of next-generation SoC devices, can be used to efficiently incorporate security. Our work proposes the implementation of QoSS (Quality of Security Service) to overcome present SoC vulnerabilities. QoSS is a novel concept for data protection that introduces security as a dimension of QoS. In this paper, we present the implementation of two security services (access control and authentication), that may be configured to assume one from several possible levels, the implementation of a technique to avoid denial-of-service (DoS) attacks, evaluate their effectiveness and estimate their impact on NoC performance.

  3. Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer

    Directory of Open Access Journals (Sweden)

    Nelson S. Yee

    2011-03-01

    Genetic analysis of pancreatic development has provided new insights into the mechanisms underlying the formation of exocrine pancreatic neoplasia. Zebrafish sweetbread (swd mutants develop hypoplastic acini and dysmorphic ducts in the exocrine pancreas, with impeded progression of cell division cycle and of epithelial growth. Positional cloning and allelic complementation have revealed that the swd mutations affect the transient receptor potential melastatin-subfamily member 7 (trpm7 gene, which encodes a divalent cation-permeable channel with kinase activity. Supplementary Mg2+ partially rescued the exocrine pancreatic defects of the trpm7 mutants by improving cell-cycle progression and growth and repressing the suppressor of cytokine signaling 3a (socs3a gene. The role of Socs3a in Trpm7-mediated signaling is supported by the findings that socs3a mRNA level is elevated in the trpm7 mutants, and antisense inhibition of socs3a expression improved their exocrine pancreatic growth. TRPM7 is generally overexpressed in human pancreatic adenocarcinoma. TRPM7-deficient cells are impaired in proliferation and arrested in the G0-G1 phases of the cell division cycle. Supplementary Mg2+ rescued the proliferative defect of the TRPM7-deficient cells. Results of this study indicate that Trpm7 regulates exocrine pancreatic development via the Mg2+-sensitive Socs3a pathway, and suggest that aberrant TRPM7-mediated signaling contributes to pancreatic carcinogenesis.

  4. Systems analysis of a security alarm system

    International Nuclear Information System (INIS)

    Schiff, A.

    1975-01-01

    When the Lawrence Livermore Laboratory found that its security alarm system was causing more false alarms and maintenance costs than LLL felt was tolerable, a systems analysis was undertaken to determine what should be done about the situation. This report contains an analysis of security alarm systems in general and ends with a review of the existing Security Alarm Control Console (SACC) and recommendations for its improvement, growth and change. (U.S.)

  5. UD-DKF-based Parameters on-line Identification Method and AEKF-Based SOC Estimation Strategy of Lithium-ion Battery

    Directory of Open Access Journals (Sweden)

    Xuanju Dang

    2014-09-01

    Full Text Available State of charge (SOC is a significant parameter for the Battery Management System (BMS. The accurate estimation of the SOC can not only guarantee the SOC remaining within a reasonable scope of work, but also prevent the battery from being over or deeply-charged to extend the lifespan of battery. In this paper, the third-order RC equivalent circuit model is adopted to describe cell characteristics and the dual Kalman filter (DKF is used online to identify model parameters for battery. In order to avoid the impacts of rounding error calculation leading to the estimation error matrix loss of non-negative qualitative which result in the filtering divergence phenomenon, the UD decomposition method is applied for filtering time and state updates simultaneously to enhance the stability of the algorithm, reduce the computational complexity and improve the high recognition accuracy. Based on the obtained model parameters, Adaptive Extended Kalman Filter (AEKF is introduced to online estimate the SOC of battery. The simulation and experimental results demonstrate that the established third-order RC equivalent circuit model is effective, and the SOC estimation has a higher precision.

  6. Synthesis of highly monodispersed Ga-soc-MOF hollow cubes, colloidosomes and nanocomposites

    KAUST Repository

    Cai, Xuechao

    2016-07-06

    Ga-soc-MOF hollow cubes with an average size of about 300 nm were prepared by a polyvinylpyrrolidone (PVP) assisted acid etching process. Colloidosomes with sizes of around 5-10 mu m composed of single-layer tetrakaidecahedron building blocks (BBs) were synthesized for the first time. Au@Ga-soc-MOF nanocomposites with excellent catalytic properties were obtained.

  7. Synthesis of highly monodispersed Ga-soc-MOF hollow cubes, colloidosomes and nanocomposites

    KAUST Repository

    Cai, Xuechao; Deng, Xiaoran; Xie, Zhongxi; Bao, Shouxin; Shi, Yanshu; Lin, Jun; Pang, Maolin; Eddaoudi, Mohamed

    2016-01-01

    Ga-soc-MOF hollow cubes with an average size of about 300 nm were prepared by a polyvinylpyrrolidone (PVP) assisted acid etching process. Colloidosomes with sizes of around 5-10 mu m composed of single-layer tetrakaidecahedron building blocks (BBs) were synthesized for the first time. Au@Ga-soc-MOF nanocomposites with excellent catalytic properties were obtained.

  8. Boosted gain programmable OpAmp with embedded gain monitor for dependable SoCs

    NARCIS (Netherlands)

    Wan, J.; Kerkhoff, Hans G.

    2011-01-01

    SoCs used in safety-critical applications need to be dependable. However in the deep-submicron region, different kinds of aging effects like negative bias temperature instability (NBTI) make the SoCs, especially the analog/mixed-signal parts, undependable. In this paper, a dependability-improved

  9. Over-expression of KdSOC1 gene affected plantlet morphogenesis in Kalanchoe daigremontiana.

    Science.gov (United States)

    Zhu, Chen; Wang, Li; Chen, Jinhua; Liu, Chenglan; Zeng, Huiming; Wang, Huafang

    2017-07-17

    Kalanchoe daigremontiana reproduces asexually by producing plantlets along the leaf margin. The aim of this study was to identify the function of the SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 gene in Kalanchoe daigremontiana (KdSOC1) during plantlet morphogenesis. In this study, KdSOC1 gene expression was detected at stem cell niche during in vitro somatic embryogenesis and plantlet morphogenesis. Disrupting endogenous auxin transportation suppressed the KdSOC1 gene response. Knockdown of the KdSOC1 gene caused a defect in cotyledon formation during the early heart stage of somatic embryogenesis. Over-expression (OE) of the KdSOC1 gene resulted in asymmetric plantlet distribution, a reduced number of plantlets, thicker leaves, and thicker vascular fibers. Higher KdPIN1 gene expression and auxin content were found in OE plant compared to those of wild-type plant leaves, which indicated possible KdSOC1 gene role in affecting auxin distribution and accumulation. KdSOC1 gene OE in DR5-GUS Arabidopsis reporting lines resulted in an abnormal auxin response pattern during different stages of somatic embryogenesis. In summary, the KdSOC1 gene OE might alter auxin distribution and accumulation along leaf margin to initiate plantlet formation and distribution, which is crucial for plasticity during plantlet formation under various environmental conditions.

  10. Untrimmed Low-Power Thermal Sensor for SoC in 22 nm Digital Fabrication Technology

    Directory of Open Access Journals (Sweden)

    Ro'ee Eitan

    2014-12-01

    Full Text Available Thermal sensors (TS are essential for achieving optimized performance and reliability in the era of nanoscale microprocessor and system on chip (SoC. Compiling with the low-power and small die area of the mobile computing, the presented TS supports a wide range of sampling frequencies with an optimized power envelope. The TS supports up to 45 K samples/s, low average power consumption, as low as 20 μW, and small core Si area of 0.013 mm2. Advanced circuit techniques are used in order to overcome process variability, ensuring inaccuracy lower than ±2 °C without any calibration. All this makes the presented thermal sensor a cost-effective, low-power solution for 22 nm nanoscale digital process technology.

  11. Use of 'sense of coherence (SOC)' scale to measure resilience in Eritrea: interrogating both the data and the scale.

    Science.gov (United States)

    Almedom, Astier M; Tesfamichael, Berhe; Saeed Mohammed, Zein; Mascie-Taylor, C G N; Alemu, Zemui

    2007-01-01

    An adapted 'sense of coherence' scale short form (SOC-13) was administered in nine languages of Eritrea with a total of 265 participants (162 women and 103 men) in order to assess 'resilience' in quantitative terms. Statistical analysis yielded significant differences in SOC scores between the displaced and non-displaced: mean=54.84 (SD=6.48) in internally displaced person (IDP) camps, compared with mean=48.94 (SD=11.99) in urban and rural settlements (t=3.831, purban (non-displaced) residents. Those in rural but traditionally mobile (pastoralist or transhumant) communities scored more or less the same as the urban non-displaced - i.e. significantly higher than those in IDP camps (purban and pastoralist/transhumant groups are similar, while women in IDP camps are lower scoring (RR=0.268, p<0.001), Hamboka women being worst affected due to their experience of serial displacement. These findings are interpreted and discussed in the light of qualitative information gleaned from the study participants' interrogation of the content of the SOC scale; and in the wider context of historical, socio-political and cultural characteristics of Eritrea. The study's implications for humanitarian and public health policy are considered.

  12. What are the effects of agricultural management on soil organic carbon (SOC) stocks?

    DEFF Research Database (Denmark)

    Söderström, Bo; Hedlund, Katarina; Jackson, Louise E.

    2014-01-01

    the physical and biological properties of the soil. Intensification of agriculture and land-use change from grasslands to croplands are generally known to deplete SOC stocks. The depletion is exacerbated through agricultural practices with low return of organic material and various mechanisms......Changes in soil organic carbon (SOC) stocks significantly influence the atmospheric C concentration. Agricultural management practices that increase SOC stocks thus may have profound effects on climate mitigation. Additional benefits include higher soil fertility since increased SOC stocks improve......, such as oxidation/mineralization, leaching and erosion. However, a systematic review comparing the efficacy of different agricultural management practices to increase SOC stocks has not yet been produced. Since there are diverging views on this matter, a systematic review would be timely for framing policies...

  13. Performance analysis of switching systems

    NARCIS (Netherlands)

    Berg, van den R.A.

    2008-01-01

    Performance analysis is an important aspect in the design of dynamic (control) systems. Without a proper analysis of the behavior of a system, it is impossible to guarantee that a certain design satisfies the system’s requirements. For linear time-invariant systems, accurate performance analyses are

  14. LOSS OF JAK2 REGULATION VIA VHL-SOCS1 E3 UBIQUITIN HETEROCOMPLEX UNDERLIES CHUVASH POLYCYTHEMIA

    Science.gov (United States)

    Russell, Ryan C.; Sufan, Roxana I.; Zhou, Bing; Heir, Pardeep; Bunda, Severa; Sybingco, Stephanie S.; Greer, Samantha N.; Roche, Olga; Heathcote, Samuel A.; Chow, Vinca W.K.; Boba, Lukasz M.; Richmond, Terri D.; Hickey, Michele M.; Barber, Dwayne L.; Cheresh, David A.; Simon, M. Celeste; Irwin, Meredith S.; Kim, William Y.; Ohh, Michael

    2011-01-01

    SUMMARY Chuvash polycythemia (CP) is a rare congenital form of polycythemia caused by homozygous R200W and H191D mutations in the von Hippel-Lindau (VHL) gene whose gene product is the principal negative regulator of hypoxia-inducible factor. However, the molecular mechanisms underlying some of the hallmark features of CP such as hypersensitivity to erythropoietin are unclear. Here, we show that VHL directly binds suppressor of cytokine signalling 1 (SOCS1) to form a heterodimeric E3 ligase that targets phosphorylated (p)JAK2 for ubiquitin-mediated destruction. In contrast, CP-associated VHL mutants have altered affinity for SOCS1 and fail to engage and degrade pJAK2. Systemic administration of a highly selective JAK2 inhibitor, TG101209, reverses the disease phenotype in vhlR200W/R200W knock-in mice, a model that faithfully recapitulates human CP. These results reveal VHL as a SOCS1-cooperative negative regulator of JAK2 and provide compelling biochemical and preclinical evidence for JAK2- targeted therapy in CP patients. PMID:21685897

  15. Power system health analysis

    International Nuclear Information System (INIS)

    Billinton, Roy; Fotuhi-Firuzabad, Mahmud; Aboreshaid, Saleh

    1997-01-01

    This paper presents a technique which combines both probabilistic indices and deterministic criteria to reflect the well-being of a power system. This technique permits power system planners, engineers and operators to maximize the probability of healthy operation as well as minimizing the probability of risky operation. The concept of system well-being is illustrated in this paper by application to the areas of operating reserve assessment and composite power system security evaluation

  16. Systems analysis made simple computerbooks

    CERN Document Server

    Antill, Lyn

    1980-01-01

    Systems Analysis: Made Simple Computerbooks introduces the essential elements of information systems analysis and design and teaches basic technical skills required for the tasks involved. The book covers the aspects to the design of an information system; information systems and the organization, including the types of information processing activity and computer-based information systems; the role of the systems analyst; and the human activity system. The text also discusses information modeling, socio-technical design, man-machine interface, and the database design. Software specification

  17. On-stream analysis systems

    International Nuclear Information System (INIS)

    Howarth, W.J.; Watt, J.S.

    1982-01-01

    An outline of some commercially available on-stream analysis systems in given. Systems based on x-ray tube/crystal spectrometers, scintillation detectors, proportional detectors and solid-state detectors are discussed

  18. Universal interface on Zynq"® SoC with CAN, RS-232, Ethernet and AXI GPIO for instrumentation & control

    International Nuclear Information System (INIS)

    Kumar, Abhijeet; Rajpal, Rachana; Pujara, Harshad; Mandaliya, Hitesh; Edappala, Praveenalal

    2016-01-01

    Highlights: • We have designed Universal Interface on Zynq"® SoC with CAN, RS-232, Ethernet and AXI GPIO for Instrumentation & Control. This project is based on Zynq"®-7000 family xc7z020clg484-1 chip. • We explored the full design flow starting from the hardware development in Vivado to software development in SDK using APIs in C language and then interfacing the host application developed in LabVIEW. • We also explored how to make custom IP with AXI bus interface in Vivado. • Useful for those who wants to make custom hardware on Zynq"® SoC. - Abstract: This paper describes an application developed on the latest Zynq"®-7000 All Programmable SoC (AP SoC) [1] devices which integrate the software programmability of an ARM"®-based processor with the hardware programmability of an FPGA, on a single device. In this paper we have implemented application which uses various interfaces like CAN, RS-232, Ethernet and AXI GPIO, so that our host application running on PC in LabVIEW can communicates with any hardware which has at least any one of the available interface. Zynq-7000 All Programmable SoCs (System On Chip) infuse customizable intelligence into today’s embedded systems to suit your unique application requirements. This family of FPGA is meant for high end application because it has huge resources on single chip. It offers you to make your own custom hardware IP, in fact we have made our custom IP called myIP in our design. The beauty of this chip is that it can write drivers for your custom IP which has AXI bus layer attached. After exporting the hardware information to the Software Development Kit (SDK), the tool is able to write drivers for your custom IP. This simplifies your development to a great extent. In a way this application provides the universal interfacing option to user. User can also write the digital data on the GPIO (General Purpose Input Output) through LabVIEW Test application GUI. This project can be used for remote control and

  19. Systems Engineering Analysis

    Directory of Open Access Journals (Sweden)

    Alexei Serna M.

    2013-07-01

    Full Text Available The challenges proposed by the development of the new computer systems demand new guidance related to engineer´s education, because they will solve these problems. In the XXI century, system engineers must be able to integrate a number of topics and knowledge disciplines that complement that traditionally has been known as Computer Systems Engineering. We have enough software development engineers, today we need professional engineers for software integration, leaders and system architects that make the most of the technological development for the benefit of society, leaders that integrate sciences to the solutions they build and propose. In this article the current situation of Computer Systems Engineering is analyzed and is presented a theory proposing the need for modifying the approach Universities have given to these careers, to achieve the education of leader engineers according to the needs of this century.

  20. Energy Usage Analysis System

    Data.gov (United States)

    General Services Administration — The EUAS application is a web based system which serves Energy Center of Expertise, under the Office of Facilitates Management and Service Programs. EUAS is used for...

  1. A multiscale framework with extended Kalman filter for lithium-ion battery SOC and capacity estimation

    International Nuclear Information System (INIS)

    Hu, Chao; Youn, Byeng D.; Chung, Jaesik

    2012-01-01

    Highlights: ► We develop a mutiscale framework with EKF to estimate SOC and capacity. ► The framework is a hybrid of coulomb counting and adaptive filtering techniques. ► It decouples SOC and capacity estimation in terms of measurement and time-scale. ► Results verify the framework achieves higher accuracy and efficiency than dual EKF. -- Abstract: State-of-charge (SOC) and capacity estimation plays an essential role in many battery-powered applications, such as electric vehicle (EV) and hybrid electric vehicle (HEV). However, commonly used joint/dual extended Kalman filter (EKF) suffers from the lack of accuracy in the capacity estimation since (i) the cell voltage is the only measurable data for the SOC and capacity estimation and updates and (ii) the capacity is very weakly linked to the cell voltage. The lack of accuracy in the capacity estimation may further reduce the accuracy in the SOC estimation due to the strong dependency of the SOC on the capacity. Furthermore, although the capacity is a slowly time-varying quantity that indicates cell state-of-health (SOH), the capacity estimation is generally performed on the same time-scale as the quickly time-varying SOC, resulting in high computational complexity. To resolve these difficulties, this paper proposes a multiscale framework with EKF for SOC and capacity estimation. The proposed framework comprises two ideas: (i) a multiscale framework to estimate SOC and capacity that exhibit time-scale separation and (ii) a state projection scheme for accurate and stable capacity estimation. Simulation results with synthetic data based on a valid cell dynamic model suggest that the proposed framework, as a hybrid of coulomb counting and adaptive filtering techniques, achieves higher accuracy and efficiency than joint/dual EKF. Results of the cycle test on Lithium-ion prismatic cells further verify the effectiveness of our framework.

  2. Suppressor of cytokine signaling (SOCS genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells.

    Directory of Open Access Journals (Sweden)

    Moon-Hong Kim

    Full Text Available Suppressor of cytokine signaling (SOCS family is an important negative regulator of cytokine signaling and deregulation of SOCS has been involved in many types of cancer. All cervical cancer cell lines tested showed lower expression of SOCS1, SOCS3, and SOCS5 than normal tissue or cell lines. The immunohistochemistry result for SOCS proteins in human cervical tissue also confirmed that normal tissue expressed higher level of SOCS proteins than neighboring tumor. Similar to the regulation of SOCS in other types of cancer, DNA methylation contributed to SOCS1 downregulation in CaSki, ME-180, and HeLa cells. However, the expression of SOCS3 or SOCS5 was not recovered by the inhibition of DNA methylation. Histone deacetylation may be another regulatory mechanism involved in SOCS1 and SOCS3 expression, however, SOCS5 expression was neither affected by DNA methylation nor histone deacetylation. Ectopic expression of SOCS1 or SOCS3 conferred radioresistance to HeLa cells, which implied SOCS signaling regulates the response to radiation in cervical cancer. In this study, we have shown that SOCS expression repressed by, in part, epigenetically and altered SOCS1 and SOCS3 expression could contribute to the radiosensitive phenotype in cervical cancer.

  3. Research on State-of-Charge (SOC) estimation using current integration based on temperature compensation

    Science.gov (United States)

    Yin, J.; Shen, Y.; Liu, X. T.; Zeng, G. J.; Liu, D. C.

    2017-11-01

    The traditional current integral method for the state-of-charge (SOC) estimation has an unusable estimation accuracy because of the current measuring error. This paper proposed a closed-loop temperature compensation method to improve the SOC estimation accuracy of current integral method by eliminating temperature drift. Through circuit simulation result in Multisim, the stability of current measuring accuracy is improved by more than 10 times. In a designed 70 charge-discharge experimental circle, the SOC estimation error with temperature compensation had 30 times less than error in normal situation without compensation.

  4. Mapping SOC in a river catchment by integrating laboratory spectra wavelength with remote sensing spectra

    DEFF Research Database (Denmark)

    Peng, Yi; Xiong, Xiong; Knadel, Maria

    There is potential to use soil ·-proximal and remote sensing derived spectra concomitantly to develop soil organic carbon (SOC) models. Yet mixing spectral data from different sources and technologies to improve soil models is still in its infancy. The objective of this study was to incorporate...... soil spectral features indicative of SOC from laboratory visible near-infrared reflectance (vis-NlR) spectra and incorporate them with remote sensing (RS) images to improve predictions of top SOC in the Skjem river catchment, Denmark. The secondary objective was to improve prediction results...

  5. Low-Power Differential SRAM design for SOC Based on the 25-um Technology

    Science.gov (United States)

    Godugunuri, Sivaprasad; Dara, Naveen; Sambasiva Nayak, R.; Nayeemuddin, Md; Singh, Yadu, Dr.; Veda, R. N. S. Sunil

    2017-08-01

    In recent, the SOC styles area unit the vast complicated styles in VLSI these SOC styles having important low-power operations problems, to comprehend this we tend to enforced low-power SRAM. However these SRAM Architectures critically affects the entire power of SOC and competitive space. To beat the higher than disadvantages, during this paper, a low-power differential SRAM design is planned. The differential SRAM design stores multiple bits within the same cell, operates at minimum in operation low-tension and space per bit. The differential SRAM design designed supported the 25-um technology using Tanner-EDA Tool.

  6. Rietveld analysis system RIETAN (translation)

    International Nuclear Information System (INIS)

    Izumi, Fujio

    1991-09-01

    This is the manual of the RIETAN system (a Rietveld analysis program) which is originally written in Japanese by Fujio Izumi. The manual consists of two parts. Part I is a general description of the fundamental concepts and methods of the RIETAN system. Part II is the user's manual of the RIETAN which mainly describes in detail how to create user's data sets, procedures of Rietveld analysis and how to read the results of analysis. (author)

  7. Integrated system reliability analysis

    DEFF Research Database (Denmark)

    Gintautas, Tomas; Sørensen, John Dalsgaard

    Specific targets: 1) The report shall describe the state of the art of reliability and risk-based assessment of wind turbine components. 2) Development of methodology for reliability and risk-based assessment of the wind turbine at system level. 3) Describe quantitative and qualitative measures...

  8. Technology-design-manufacturing co-optimization for advanced mobile SoCs

    Science.gov (United States)

    Yang, Da; Gan, Chock; Chidambaram, P. R.; Nallapadi, Giri; Zhu, John; Song, S. C.; Xu, Jeff; Yeap, Geoffrey

    2014-03-01

    How to maintain the Moore's Law scaling beyond the 193 immersion resolution limit is the key question semiconductor industry needs to answer in the near future. Process complexity will undoubtfully increase for 14nm node and beyond, which brings both challenges and opportunities for technology development. A vertically integrated design-technologymanufacturing co-optimization flow is desired to better address the complicated issues new process changes bring. In recent years smart mobile wireless devices have been the fastest growing consumer electronics market. Advanced mobile devices such as smartphones are complex systems with the overriding objective of providing the best userexperience value by harnessing all the technology innovations. Most critical system drivers are better system performance/power efficiency, cost effectiveness, and smaller form factors, which, in turns, drive the need of system design and solution with More-than-Moore innovations. Mobile system-on-chips (SoCs) has become the leading driver for semiconductor technology definition and manufacturing. Here we highlight how the co-optimization strategy influenced architecture, device/circuit, process technology and package, in the face of growing process cost/complexity and variability as well as design rule restrictions.

  9. OLDAPS: Obsidian Least Destructive Analysis Provenancing System

    Energy Technology Data Exchange (ETDEWEB)

    Eder, F.M.; Sterba, J.H.; Bichler, M. [Atominstitut, Vienna University of Technology, Vienna (Austria); Neelmeijer, C.; Merchel, S. [Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden (Germany); Pearce, N.J.G. [Institute of Geography and Earth Sciences, Aberystwyth University, Wales (United Kingdom)

    2013-07-01

    Full text: The natural volcanic glass obsidian is one of the classical objects of archaeometric analyses. Reliable provenancing by means of the highly specific chemical composition, the 'chemical fingerprint', can provide information about trading routes, extension of territory, long-distance contacts and the mobility of prehistoric people. Since the pioneer work of Cann and Renfrew in 1964 [1] various analytical methods have been employed on obsidian samples in order to locate their provenance. The existing data already offers important knowledge about long-distance interactions between prehistoric human populations. However, most applied techniques just show a small part of the element spectrum. Latest studies showed that published results gained by different analytical methods are not consistent due to systematic errors [2-3]. Therefore, the application of three complementary analytical techniques on the same set of raw material samples allows both a better characterization of obsidian sources and a comparison and validation of analytical results. The aim of this multi-methodical approach is to apply in particular: 1) lon Beam Analysis (IBA) comprising of Particle Induced X-ray Emission (PIXE) and Particle Induced Gamma-ray Emission (PIGE), 2) Instrumental Neutron Activation Analysis (INAA), 3) Laser Ablation-lnductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS), to detect a maximum element spectrum and to compare element concentrations determined with at least two analytical techniques. This approach should check the accuracy and reliability of analytical results and should show a maximum of compositional differences between European obsidian sources to reveal the most characteristic 'chemical fingerprint' composed of more than 40 elements. These investigations are part of a new multi-methodical analytical database called the 'Obsidian Least Destructive Analysis Provenancing System' (OLDAPS). This novel scientific approach for

  10. Gas-particle partitioning of semivolatile organic compounds (SOCs) on mixtures of aerosols in a smog chamber.

    Science.gov (United States)

    Chandramouli, Bharadwaj; Jang, Myoseon; Kamens, Richard M

    2003-09-15

    The partitioning behavior of a set of diverse SOCs on two and three component mixtures of aerosols from different sources was studied using smog chamber experimental data. A set of SOCs of different compound types was introduced into a system containing a mixture of aerosols from two or more sources. Gas and particle samples were taken using a filter-filter-denuder sampling system, and a partitioning coefficient Kp was estimated using Kp = Cp/(CgTSP). Particle size distributions were measured using a differential mobility analyzer and a light scattering detector. Gas and particle samples were analyzed using GCMS. The aerosol composition in the chamber was tracked chemically using a combination of signature compounds and the organic matter mass fraction (f(om)) of the individual aerosol sources. The physical nature of the aerosol mixture in the chamber was determined using particle size distributions, and an aggregate Kp was estimated from theoretically calculated Kp on the individual sources. Model fits for Kp showed that when the mixture involved primary sources of aerosol, the aggregate Kp of the mixture could be successfully modeled as an external mixture of the Kp on the individual aerosols. There were significant differences observed for some SOCs between modeling the system as an external and as an internal mixture. However, when one of the aerosol sources was secondary, the aggregate model Kp required incorporation of the secondary aerosol products on the preexisting aerosol for adequate model fits. Modeling such a system as an external mixture grossly overpredicted the Kp of alkanes in the mixture. Indirect evidence of heterogeneous, acid-catalyzed reactions in the particle phase was also seen, leading to a significant increase in the polarity of the resulting aerosol mix and a resulting decrease in the observed Kp of alkanes in the chamber. The model was partly consistent with this decrease but could not completely explain the reduction in Kp because of

  11. Arctic Climate Systems Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ivey, Mark D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Robinson, David G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Boslough, Mark B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Backus, George A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Peterson, Kara J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); van Bloemen Waanders, Bart G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Swiler, Laura Painton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Desilets, Darin Maurice [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Reinert, Rhonda Karen [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-03-01

    This study began with a challenge from program area managers at Sandia National Laboratories to technical staff in the energy, climate, and infrastructure security areas: apply a systems-level perspective to existing science and technology program areas in order to determine technology gaps, identify new technical capabilities at Sandia that could be applied to these areas, and identify opportunities for innovation. The Arctic was selected as one of these areas for systems level analyses, and this report documents the results. In this study, an emphasis was placed on the arctic atmosphere since Sandia has been active in atmospheric research in the Arctic since 1997. This study begins with a discussion of the challenges and benefits of analyzing the Arctic as a system. It goes on to discuss current and future needs of the defense, scientific, energy, and intelligence communities for more comprehensive data products related to the Arctic; assess the current state of atmospheric measurement resources available for the Arctic; and explain how the capabilities at Sandia National Laboratories can be used to address the identified technological, data, and modeling needs of the defense, scientific, energy, and intelligence communities for Arctic support.

  12. The mechanisms behind the formation of a strong Sense of Coherence (SOC): The role of migration and integration

    NARCIS (Netherlands)

    Slootjes, J.; Keuzenkamp, Saskia; Saharso, S.

    2017-01-01

    Considering how much we know about the impact of the Sense of Coherence (SOC) on different health-related outcomes, we know surprisingly little about how a strong SOC actually develops. In this study we examine the mechanisms behind the formation of a strong SOC and study the role of migration,

  13. SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice

    DEFF Research Database (Denmark)

    Zadjali, Fahad; Santana-Farre, Ruyman; Vesterlund, Mattias

    2012-01-01

    in the development of diet-induced hepatic steatosis and insulin resistance. SOCS2-knockout (SOCS2(-/-)) mice and wild-type littermates were fed for 4 mo with control or high-fat diet, followed by assessment of insulin sensitivity, hepatic lipid content, and expression of inflammatory cytokines. SOCS2(-/-) mice...

  14. DMPD: Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17070092 Suppressor of cytokine signaling (SOCS) 2, a protein with multiple function...Epub 2006 Oct 27. (.png) (.svg) (.html) (.csml) Show Suppressor of cytokine signaling (SOCS) 2, a protein with multiple function...SOCS) 2, a protein with multiple functions. Authors Rico-Bautista E, Flores-Morales A, Fernandez-Perez L. Pu

  15. Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

    DEFF Research Database (Denmark)

    Greenhalgh, Christopher J; Metcalf, Donald; Thaus, Anne L

    2002-01-01

    Suppressor of cytokine signaling (SOCS)-2 is a member of a family of intracellular proteins implicated in the negative regulation of cytokine signaling. The generation of SOCS-2-deficient mice, which grow to one and a half times the size of their wild-type littermates, suggests that SOCS-2 may at...

  16. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

    DEFF Research Database (Denmark)

    Adams, T E; Hansen, J A; Starr, R

    1998-01-01

    Four members (SOCS-1, SOCS-2, SOCS-3, and CIS) of a family of cytokine-inducible, negative regulators of cytokine receptor signaling have recently been identified. To address whether any of these genes are induced in response to growth hormone (GH), serum-starved 3T3-F442A fibroblasts were incuba...

  17. DMPD: Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18406369 Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins...svg) (.html) (.csml) Show Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins. ...PubmedID 18406369 Title Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins

  18. System Analysis and Risk Assessment (SARA) system

    International Nuclear Information System (INIS)

    Krantz, E.A.; Russell, K.D.; Stewart, H.D.; Van Siclen, V.S.

    1986-01-01

    Utilization of Probabilistic Risk Assessment (PRA) related information in the day-to-day operation of plant systems has, in the past, been impracticable due to the size of the computers needed to run PRA codes. This paper discusses a microcomputer-based database system which can greatly enhance the capability of operators or regulators to incorporate PRA methodologies into their routine decision making. This system is called the System Analysis and Risk Assessment (SARA) system. SARA was developed by EG and G Idaho, Inc. at the Idaho National Engineering Laboratory to facilitate the study of frequency and consequence analyses of accident sequences from a large number of light water reactors (LWRs) in this country. This information is being amassed by several studies sponsored by the United States Nuclear Regulatory Commission (USNRC). To meet the need of portability and accessibility, and to perform the variety of calculations necessary, it was felt that a microcomputer-based system would be most suitable

  19. Systems analysis-independent analysis and verification

    Energy Technology Data Exchange (ETDEWEB)

    Badin, J.S.; DiPietro, J.P. [Energetics, Inc., Columbia, MD (United States)

    1995-09-01

    The DOE Hydrogen Program is supporting research, development, and demonstration activities to overcome the barriers to the integration of hydrogen into the Nation`s energy infrastructure. Much work is required to gain acceptance of hydrogen energy system concepts and to develop them for implementation. A systems analysis database has been created that includes a formal documentation of technology characterization profiles and cost and performance information. Through a systematic and quantitative approach, system developers can understand and address important issues and thereby assure effective and timely commercial implementation. This project builds upon and expands the previously developed and tested pathway model and provides the basis for a consistent and objective analysis of all hydrogen energy concepts considered by the DOE Hydrogen Program Manager. This project can greatly accelerate the development of a system by minimizing the risk of costly design evolutions, and by stimulating discussions, feedback, and coordination of key players and allows them to assess the analysis, evaluate the trade-offs, and to address any emerging problem areas. Specific analytical studies will result in the validation of the competitive feasibility of the proposed system and identify system development needs. Systems that are investigated include hydrogen bromine electrolysis, municipal solid waste gasification, electro-farming (biomass gasifier and PEM fuel cell), wind/hydrogen hybrid system for remote sites, home electrolysis and alternate infrastructure options, renewable-based electrolysis to fuel PEM fuel cell vehicle fleet, and geothermal energy used to produce hydrogen. These systems are compared to conventional and benchmark technologies. Interim results and findings are presented. Independent analyses emphasize quality, integrity, objectivity, a long-term perspective, corporate memory, and the merging of technical, economic, operational, and programmatic expertise.

  20. Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity

    DEFF Research Database (Denmark)

    Beck Jørgensen, Sebastian; O'Neill, Hayley M; Sylow, Lykke

    2013-01-01

    Obesity is associated with chronic low-grade inflammation that contributes to defects in energy metabolism and insulin resistance. Suppressor of cytokine signaling (SOCS)-3 expression is increased in skeletal muscle of obese humans. SOCS3 inhibits leptin signaling in the hypothalamus and insulin...... of hyperinsulinemia and insulin resistance because of enhanced skeletal muscle insulin receptor substrate 1 (IRS1) and Akt phosphorylation that resulted in increased skeletal muscle glucose uptake. These data indicate that skeletal muscle SOCS3 does not play a critical role in regulating muscle development or energy...... expenditure, but it is an important contributing factor for inhibiting insulin sensitivity in obesity. Therapies aimed at inhibiting SOCS3 in skeletal muscle may be effective in reversing obesity-related glucose intolerance and insulin resistance....

  1. The impact of soil redistribution on SOC pools in a Mediterranean agroforestry catchment

    Science.gov (United States)

    Quijano, Laura; Gaspar, Leticia; Lizaga, Iván; Navas, Ana

    2017-04-01

    Soil redistribution processes play an important role influencing the spatial distribution patterns of soil and associated soil organic carbon (SOC) at landscape scale. Information on drivers of SOC dynamics is key for evaluating both soil degradation and SOC stability that can affect soil quality and sustainability. 137Cs measurements provide a very effective tool to infer spatial patterns of soil redistribution and quantify soil redistribution rates in different landscapes, but to date these data are scarce in mountain Mediterranean agroecosystems. We evaluate the effect of soil redistribution on SOC and SOC pools in relation to land use in a Mediterranean mountain catchment (246 ha). To this purpose, two hundred and four soil bulk cores were collected on a 100 m grid in the Estaña lakes catchment located in the central sector of the Spanish Pyrenees (31T 4656250N 295152E). The study area is an agroforestry and endorheic catchment characterized by the presence of evaporite dissolution induced dolines, some of which host permanent lakes. The selected landscape is representative of rainfed areas of Mediterranean continental climate with erodible lithology and shallow soils, and characterized by an intense anthropogenic activity through cultivation and water management. The cultivated and uncultivated areas are heterogeneously distributed. SOC and SOC pools (the active and decomposable fraction, ACF and the stable carbon fraction SCF) were measured by the dry combustion method and soil redistribution rates were derived from 137Cs measurements. The results showed that erosion predominated in the catchment, most of soil samples were identified as eroded sites (n=114) with an average erosion rate of 26.9±51.4 Mg ha-1 y-1 whereas the mean deposition rate was 13.0±24.2 Mg ha-1 y-1. In cultivated soils (n=54) the average of soil erosion rate was significantly higher (78.5±74.4 Mg ha-1 y-1) than in uncultivated soils (6.8±10.4 Mg ha-1 y-1). Similarly, the mean of soil

  2. SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer

    DEFF Research Database (Denmark)

    Iglesias Gato, Diego; Chuan, Yin Choy; Wikström, Pernilla

    2014-01-01

    ) as mediator of the cross talk between androgens and GH signals in the prostate and its potential role as tumor suppressor in prostate cancer (PCa). We observed that SOCS2 protein levels assayed by immunohistochemistry are elevated in hormone therapy-naive localized prostatic adenocarcinoma in comparison...... of transcription 5 protein (STAT5) and androgen receptor-dependent transcription. Consequentially, SOCS2 inhibits GH activation of Janus kinase 2, Src and STAT5 as well as both cell invasion and cell proliferation in vitro. In vivo, SOCS2 limits proliferation and production of IGF-1 in the prostate in response......Anabolic signals such as androgens and the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis play an essential role in the normal development of the prostate but also in its malignant transformation. In this study, we investigated the role of suppressor of cytokine signaling 2 (SOCS2...

  3. Integrated piping structural analysis system

    International Nuclear Information System (INIS)

    Motoi, Toshio; Yamadera, Masao; Horino, Satoshi; Idehata, Takamasa

    1979-01-01

    Structural analysis of the piping system for nuclear power plants has become larger in scale and in quantity. In addition, higher quality analysis is regarded as of major importance nowadays from the point of view of nuclear plant safety. In order to fulfill to the above requirements, an integrated piping structural analysis system (ISAP-II) has been developed. Basic philosophy of this system is as follows: 1. To apply the date base system. All information is concentrated. 2. To minimize the manual process in analysis, evaluation and documentation. Especially to apply the graphic system as much as possible. On the basis of the above philosophy four subsystems were made. 1. Data control subsystem. 2. Analysis subsystem. 3. Plotting subsystem. 4. Report subsystem. Function of the data control subsystem is to control all information of the data base. Piping structural analysis can be performed by using the analysis subsystem. Isometric piping drawing and mode shape, etc. can be plotted by using the plotting subsystem. Total analysis report can be made without the manual process through the reporting subsystem. (author)

  4. Kepler: A Search for Terrestrial Planets - SOC 9.3 DR25 Pipeline Parameter Configuration Reports

    Science.gov (United States)

    Campbell, Jennifer R.

    2017-01-01

    This document describes the manner in which the pipeline and algorithm parameters for the Kepler Science Operations Center (SOC) science data processing pipeline were managed. This document is intended for scientists and software developers who wish to better understand the software design for the final Kepler codebase (SOC 9.3) and the effect of the software parameters on the Data Release (DR) 25 archival products.

  5. Synergy of SOCS-1 Inhibition and Microbial-Based Cancer Vaccines

    Science.gov (United States)

    2013-09-01

    SH2 domain; a docking motif for interaction with tyrosine...IL‐ 4, IL‐7, IL‐15), IFN‐α, IFN‐γ, and IL‐12. While the SH2 domain targets the SOCS proteins to specific molecules within the JAK‐ STAT pathway, the...SOCS‐box functions as an E3 ubiquitin ligase, promoting degradation of the cytokine receptor complex. SOCS1 also contains a kinase inhibitory

  6. Design and implementation of a reconfigurable mixed-signal SoC based on field programmable analog arrays

    Science.gov (United States)

    Liu, Lintao; Gao, Yuhan; Deng, Jun

    2017-11-01

    This work presents a reconfigurable mixed-signal system-on-chip (SoC), which integrates switched-capacitor-based field programmable analog arrays (FPAA), analog-to-digital converter (ADC), digital-to-analog converter, digital down converter , digital up converter, 32-bit reduced instruction-set computer central processing unit (CPU) and other digital IPs on a single chip with 0.18 μm CMOS technology. The FPAA intellectual property could be reconfigured as different function circuits, such as gain amplifier, divider, sine generator, and so on. This single-chip integrated mixed-signal system is a complete modern signal processing system, occupying a die area of 7 × 8 mm 2 and consuming 719 mW with a clock frequency of 150 MHz for CPU and 200 MHz for ADC/DAC. This SoC chip can help customers to shorten design cycles, save board area, reduce the system power consumption and depress the system integration risk, which would afford a big prospect of application for wireless communication. Project supported by the National High Technology and Development Program of China (No. 2012AA012303).

  7. A model based on Rock-Eval thermal analysis to quantify the size of the centennially persistent organic carbon pool in temperate soils

    Science.gov (United States)

    Cécillon, Lauric; Baudin, François; Chenu, Claire; Houot, Sabine; Jolivet, Romain; Kätterer, Thomas; Lutfalla, Suzanne; Macdonald, Andy; van Oort, Folkert; Plante, Alain F.; Savignac, Florence; Soucémarianadin, Laure N.; Barré, Pierre

    2018-05-01

    Changes in global soil carbon stocks have considerable potential to influence the course of future climate change. However, a portion of soil organic carbon (SOC) has a very long residence time ( > 100 years) and may not contribute significantly to terrestrial greenhouse gas emissions during the next century. The size of this persistent SOC reservoir is presumed to be large. Consequently, it is a key parameter required for the initialization of SOC dynamics in ecosystem and Earth system models, but there is considerable uncertainty in the methods used to quantify it. Thermal analysis methods provide cost-effective information on SOC thermal stability that has been shown to be qualitatively related to SOC biogeochemical stability. The objective of this work was to build the first quantitative model of the size of the centennially persistent SOC pool based on thermal analysis. We used a unique set of 118 archived soil samples from four agronomic experiments in northwestern Europe with long-term bare fallow and non-bare fallow treatments (e.g., manure amendment, cropland and grassland) as a sample set for which estimating the size of the centennially persistent SOC pool is relatively straightforward. At each experimental site, we estimated the average concentration of centennially persistent SOC and its uncertainty by applying a Bayesian curve-fitting method to the observed declining SOC concentration over the duration of the long-term bare fallow treatment. Overall, the estimated concentrations of centennially persistent SOC ranged from 5 to 11 g C kg-1 of soil (lowest and highest boundaries of four 95 % confidence intervals). Then, by dividing the site-specific concentrations of persistent SOC by the total SOC concentration, we could estimate the proportion of centennially persistent SOC in the 118 archived soil samples and the associated uncertainty. The proportion of centennially persistent SOC ranged from 0.14 (standard deviation of 0.01) to 1 (standard deviation

  8. SUBSURFACE VISUAL ALARM SYSTEM ANALYSIS

    International Nuclear Information System (INIS)

    D.W. Markman

    2001-01-01

    The ''Subsurface Fire Hazard Analysis'' (CRWMS M andO 1998, page 61), and the document, ''Title III Evaluation Report for the Surface and Subsurface Communication System'', (CRWMS M andO 1999a, pages 21 and 23), both indicate the installed communication system is adequate to support Exploratory Studies Facility (ESF) activities with the exception of the mine phone system for emergency notification purposes. They recommend the installation of a visual alarm system to supplement the page/party phone system The purpose of this analysis is to identify data communication highway design approaches, and provide justification for the selected or recommended alternatives for the data communication of the subsurface visual alarm system. This analysis is being prepared to document a basis for the design selection of the data communication method. This analysis will briefly describe existing data or voice communication or monitoring systems within the ESF, and look at how these may be revised or adapted to support the needed data highway of the subsurface visual alarm. system. The existing PLC communication system installed in subsurface is providing data communication for alcove No.5 ventilation fans, south portal ventilation fans, bulkhead doors and generator monitoring system. It is given that the data communication of the subsurface visual alarm system will be a digital based system. It is also given that it is most feasible to take advantage of existing systems and equipment and not consider an entirely new data communication system design and installation. The scope and primary objectives of this analysis are to: (1) Briefly review and describe existing available data communication highways or systems within the ESF. (2) Examine technical characteristics of an existing system to disqualify a design alternative is paramount in minimizing the number of and depth of a system review. (3) Apply general engineering design practices or criteria such as relative cost, and degree

  9. PLACE OF PRODUCTION COSTS SYSTEM ANALYSIS IN SYSTEM ANALYSIS

    Directory of Open Access Journals (Sweden)

    Mariia CHEREDNYCHENKO

    2016-12-01

    Full Text Available Current economic conditions require the development and implementation of an adequate system of production costs, which would ensure a steady profit growth and production volumes in a highly competitive, constantly increasing input prices and tariffs. This management system must be based on an integrated production costs system analysis (PCSA, which would provide all operating costs management subsystems necessary information to design and make better management decisions. It provides a systematic analysis of more opportunities in knowledge, creating conditions of integrity mechanism knowledge object consisting of elements that show intersystem connections, each of which has its own defined and limited objectives, relationship with the environment.

  10. Evaluation of SOC for the presumptive identification of Candida albicans and Cryptococcus neoformans.

    Science.gov (United States)

    Fleming, W H; Knezek, K L; Dorn, G L

    1987-01-01

    SOC, a fungal growth medium composed of Solryth, oxgall, and caffeic acid, was evaluated as a medium to provide rapid, differential identification of Candida albicans and Cryptococcus neoformans. Using a variety of common isolation media to produce the yeast inocula, the germ tube methods tested ranked in the following order of decreasing sensitivity: SOC (97% +/- 1), serum (92% +/- 5), rabbit coagulase plasma with EDTA in combination with tryptic soy broth (89% +/- 5), TOC (89% +/- 6), and rabbit coagulase plasma with EDTA (83% +/- 4). In chlamydospore production, SOC also proved to be the most sensitive after 24 h incubation: SOC (96% +/- 2), TOC (80% +/- 2), and cornmeal-Tween 80 agar (14% +/- 3). Other medically important yeasts showed normal patterns of growth within 24 h on SOC, thus assisting in their identification. Eighty strains of Cryptococcus neoformans showed characteristic brown pigmentation on SOC and TOC within 18 h, while all other species of the genus Cryptococcus and 229 Candida isolates did not show a change in pigmentation.

  11. Magnetic Signature Analysis & Validation System

    National Research Council Canada - National Science Library

    Vliet, Scott

    2001-01-01

    The Magnetic Signature Analysis and Validation (MAGSAV) System is a mobile platform that is used to measure, record, and analyze the perturbations to the earth's ambient magnetic field caused by object such as armored vehicles...

  12. Co-verification of hardware and software for ARM SoC design

    CERN Document Server

    Andrews, Jason

    2004-01-01

    Hardware/software co-verification is how to make sure that embedded system software works correctly with the hardware, and that the hardware has been properly designed to run the software successfully -before large sums are spent on prototypes or manufacturing. This is the first book to apply this verification technique to the rapidly growing field of embedded systems-on-a-chip(SoC). As traditional embedded system design evolves into single-chip design, embedded engineers must be armed with the necessary information to make educated decisions about which tools and methodology to deploy. SoC verification requires a mix of expertise from the disciplines of microprocessor and computer architecture, logic design and simulation, and C and Assembly language embedded software. Until now, the relevant information on how it all fits together has not been available. Andrews, a recognized expert, provides in-depth information about how co-verification really works, how to be successful using it, and pitfalls to avoid. H...

  13. Implementation of SoC Based Real-Time Electromagnetic Transient Simulator

    Directory of Open Access Journals (Sweden)

    I. Herrera-Leandro

    2017-01-01

    Full Text Available Real-time electromagnetic transient simulators are important tools in the design stage of new control and protection systems for power systems. Real-time simulators are used to test and stress new devices under similar conditions that the device will deal with in a real network with the purpose of finding errors and bugs in the design. The computation of an electromagnetic transient is complex and computationally demanding, due to features such as the speed of the phenomenon, the size of the network, and the presence of time variant and nonlinear elements in the network. In this work, the development of a SoC based real-time and also offline electromagnetic transient simulator is presented. In the design, the required performance is met from two sides, (a using a technique to split the power system into smaller subsystems, which allows parallelizing the algorithm, and (b with specialized and parallel hardware designed to boost the solution flow. The results of this work have shown that for the proposed case studies, based on a balanced distribution of the node of subsystems, the proposed approach has decreased the total simulation time by up to 99 times compared with the classical approach running on a single high performance 32-bit embedded processor ARM-Cortex A9.

  14. Computerized ECT data analysis system

    International Nuclear Information System (INIS)

    Miyake, Y.; Fukui, S.; Iwahashi, Y.; Matsumoto, M.; Koyama, K.

    1988-01-01

    For the analytical method of the eddy current testing (ECT) of steam generator tubes in nuclear power plants, the authors have developed the computerized ECT data analysis system using a large-scale computer with a high-resolution color graphic display. This system can store acquired ECT data up to 15 steam generators, and ECT data can be analyzed immediately on the monitor in dialogue communication with a computer. Analyzed results of ECT data are stored and registered in the data base. This system enables an analyst to perform sorting and collecting of data under various conditions and obtain the results automatically, and also to make a plan of tube repair works. This system has completed the test run, and has been used for data analysis at the annual inspection of domestic plants. This paper describes an outline, features and examples of the computerized eddy current data analysis system for steam generator tubes in PWR nuclear power plants

  15. System safety engineering analysis handbook

    Science.gov (United States)

    Ijams, T. E.

    1972-01-01

    The basic requirements and guidelines for the preparation of System Safety Engineering Analysis are presented. The philosophy of System Safety and the various analytic methods available to the engineering profession are discussed. A text-book description of each of the methods is included.

  16. Static Analysis for Systems Biology

    DEFF Research Database (Denmark)

    Nielson, Flemming; Nielson, Hanne Riis; Rosa, D. Schuch da

    2004-01-01

    This paper shows how static analysis techniques can help understanding biological systems. Based on a simple example we illustrate the outcome of performing three different analyses extracting information of increasing precision. We conclude by reporting on the potential impact and exploitation o...... of these techniques in systems biology....

  17. Automated activation-analysis system

    International Nuclear Information System (INIS)

    Minor, M.M.; Hensley, W.K.; Denton, M.M.; Garcia, S.R.

    1981-01-01

    An automated delayed neutron counting and instrumental neutron activation analysis system has been developed at Los Alamos National Laboratory's Omega West Reactor (OWR) to analyze samples for uranium and 31 additional elements with a maximum throughput of 400 samples per day. The system and its mode of operation for a large reconnaissance survey are described

  18. Artificial Neural Network Analysis System

    Science.gov (United States)

    2001-02-27

    Contract No. DASG60-00-M-0201 Purchase request no.: Foot in the Door-01 Title Name: Artificial Neural Network Analysis System Company: Atlantic... Artificial Neural Network Analysis System 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Powell, Bruce C 5d. PROJECT NUMBER 5e. TASK NUMBER...34) 27-02-2001 Report Type N/A Dates Covered (from... to) ("DD MON YYYY") 28-10-2000 27-02-2001 Title and Subtitle Artificial Neural Network Analysis

  19. Noise and vibration analysis system

    International Nuclear Information System (INIS)

    Johnsen, J.R.; Williams, R.L.

    1985-01-01

    The analysis of noise and vibration data from an operating nuclear plant can provide valuable information that can identify and characterize abnormal conditions. Existing plant monitoring equipment, such as loose parts monitoring systems (LPMS) and neutron flux detectors, may be capable of gathering noise data, but may lack the analytical capability to extract useful meanings hidden in the noise. By analyzing neutron noise signals, the structural motion and integrity of core components can be assessed. Computer analysis makes trending of frequency spectra within a fuel cycle and from one cycle to another a practical means of core internals monitoring. The Babcock and Wilcox Noise and Vibration Analysis System (NVAS) is a powerful, compact system that can automatically perform complex data analysis. The system can acquire, process, and store data, then produce report-quality plots of the important parameter. Software to perform neutron noise analysis and loose parts analysis operates on the same hardware package. Since the system is compact, inexpensive, and easy to operate, it allows utilities to perform more frequency analyses without incurring high costs and provides immediate results

  20. Space elevator systems level analysis

    Energy Technology Data Exchange (ETDEWEB)

    Laubscher, B. E. (Bryan E.)

    2004-01-01

    The Space Elevator (SE) represents a major paradigm shift in space access. It involves new, untried technologies in most of its subsystems. Thus the successful construction of the SE requires a significant amount of development, This in turn implies a high level of risk for the SE. This paper will present a systems level analysis of the SE by subdividing its components into their subsystems to determine their level of technological maturity. such a high-risk endeavor is to follow a disciplined approach to the challenges. A systems level analysis informs this process and is the guide to where resources should be applied in the development processes. It is an efficient path that, if followed, minimizes the overall risk of the system's development. systems level analysis is that the overall system is divided naturally into its subsystems, and those subsystems are further subdivided as appropriate for the analysis. By dealing with the complex system in layers, the parameter space of decisions is kept manageable. Moreover, A rational way to manage One key aspect of a resources are not expended capriciously; rather, resources are put toward the biggest challenges and most promising solutions. This overall graded approach is a proven road to success. The analysis includes topics such as nanotube technology, deployment scenario, power beaming technology, ground-based hardware and operations, ribbon maintenance and repair and climber technology.

  1. The ALICE analysis train system

    CERN Document Server

    Zimmermann, Markus

    2015-01-01

    In the ALICE experiment hundreds of users are analyzing big datasets on a Grid system. High throughput and short turn-around times are achieved by a centralized system called the LEGO trains. This system combines analysis from different users in so-called analysis trains which are then executed within the same Grid jobs thereby reducing the number of times the data needs to be read from the storage systems. The centralized trains improve the performance, the usability for users and the bookkeeping in comparison to single user analysis. The train system builds upon the already existing ALICE tools, i.e. the analysis framework as well as the Grid submission and monitoring infrastructure. The entry point to the train system is a web interface which is used to configure the analysis and the desired datasets as well as to test and submit the train. Several measures have been implemented to reduce the time a train needs to finish and to increase the CPU efficiency.

  2. Nuclear fuel cycle system analysis

    International Nuclear Information System (INIS)

    Ko, W. I.; Kwon, E. H.; Kim, S. G.; Park, B. H.; Song, K. C.; Song, D. Y.; Lee, H. H.; Chang, H. L.; Jeong, C. J.

    2012-04-01

    The nuclear fuel cycle system analysis method has been designed and established for an integrated nuclear fuel cycle system assessment by analyzing various methodologies. The economics, PR(Proliferation Resistance) and environmental impact evaluation of the fuel cycle system were performed using improved DB, and finally the best fuel cycle option which is applicable in Korea was derived. In addition, this research is helped to increase the national credibility and transparency for PR with developing and fulfilling PR enhancement program. The detailed contents of the work are as follows: 1)Establish and improve the DB for nuclear fuel cycle system analysis 2)Development of the analysis model for nuclear fuel cycle 3)Preliminary study for nuclear fuel cycle analysis 4)Development of overall evaluation model of nuclear fuel cycle system 5)Overall evaluation of nuclear fuel cycle system 6)Evaluate the PR for nuclear fuel cycle system and derive the enhancement method 7)Derive and fulfill of nuclear transparency enhancement method The optimum fuel cycle option which is economical and applicable to domestic situation was derived in this research. It would be a basis for establishment of the long-term strategy for nuclear fuel cycle. This work contributes for guaranteeing the technical, economical validity of the optimal fuel cycle option. Deriving and fulfillment of the method for enhancing nuclear transparency will also contribute to renewing the ROK-U.S Atomic Energy Agreement in 2014

  3. Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells.

    Science.gov (United States)

    Takahashi, Yuki; Kaneda, Haruka; Takasuka, Nana; Hattori, Kayoko; Nishikawa, Makiya; Watanabe, Yoshihiko; Takakura, Yoshinobu

    2008-08-01

    The suppressor of cytokine signaling (SOCS) proteins, negative regulators of interferon (IFN)-induced signaling pathways, is involved in IFN resistance of tumor cells. To improve the growth inhibitory effect of IFN-beta and IFN-gamma on a murine melanoma cell line, B16-BL6, and a murine colon carcinoma cell line, Colon26 cells, SOCS-1 and SOCS-3 gene expression in tumor cells was downregulated by transfection of plasmid DNA expressing short hairpin RNA targeting one of these genes (pshSOCS-1 and pshSOCS-3, respectively). Transfection of pshSOCS-1 significantly increased the antiproliferative effect of IFN-gamma on B16-BL6 cells. However, any other combinations of plasmids and IFN had little effect on the growth of B16-BL6 cells. In addition, transfection of pshSOCS-1 and pshSOCS-3 produced little improvement in the effect of IFN on Colon26 cells. To understand the mechanism underlining these findings, the level of SOCS gene expression was measured by real time polymerase chain reaction. Addition of IFN-gamma greatly increased the SOCS-1 mRNA expression in B16-BL6 cells. Taking into account the synergistic effect of pshSOCS-1 and IFN-gamma on the growth of B16-BL6 cells, these findings suggest that IFN-gamma-induced high SOCS-1 gene expression in B16-BL6 cells significantly interferes with the antiproliferative effect of IFN-gamma. These results indicate that silencing SOCS gene expression can be an effective strategy to enhance the antitumor effect of IFN under conditions in which the SOCS gene expression is upregulated by IFN.

  4. Sparing analysis for FGD systems

    International Nuclear Information System (INIS)

    Dene, C.E.; Weiss, J.; Twombly, M.A.; Witt, J.

    1992-01-01

    With the passage of federal clean air legislation, utilities will be evaluating the capability of various flue gas desulfurization (FGD) system design configurations and operating scenarios to meet sulfur dioxide (SO 2 ) removal goals. The primary goal in reviewing these alternatives will be to optimize SO 2 removal capability in relation to power production costs. The Electric Power Research institute (EPRI) and its contractor, ARINC Research Corporation, have developed an automated FGD Analysis System that can evaluate competing FGD design alternatives in terms of their SO 2 removal capability and operating costs. The FGD Analysis System can be used to evaluate different design configurations for new systems or to calculate the effect of changes in component reliability for existing FGD systems. The system is based on the EPRI UNIRAM methodology and evaluates the impact of alternative FGD component configurations on the expected unit emission rates. The user interactively enters FGD design data, unit SO 2 generation-level data, and FGD chemical additive-level data for the design configuration to be evaluated. The system then calculates expected SO 2 removal capability and operating cost data for operation of the design configuration over a user specified time period. This paper provides a brief description of the FGD Analysis System and presents sample results for three typical design configurations with different redundancy levels

  5. Weld analysis and control system

    Science.gov (United States)

    Kennedy, Larry Z. (Inventor); Rodgers, Michael H. (Inventor); Powell, Bradley W. (Inventor); Burroughs, Ivan A. (Inventor); Goode, K. Wayne (Inventor)

    1994-01-01

    The invention is a Weld Analysis and Control System developed for active weld system control through real time weld data acquisition. Closed-loop control is based on analysis of weld system parameters and weld geometry. The system is adapted for use with automated welding apparatus having a weld controller which is capable of active electronic control of all aspects of a welding operation. Enhanced graphics and data displays are provided for post-weld analysis. The system provides parameter acquisition, including seam location which is acquired for active torch cross-seam positioning. Torch stand-off is also monitored for control. Weld bead and parent surface geometrical parameters are acquired as an indication of weld quality. These parameters include mismatch, peaking, undercut, underfill, crown height, weld width, puddle diameter, and other measurable information about the weld puddle regions, such as puddle symmetry, etc. These parameters provide a basis for active control as well as post-weld quality analysis and verification. Weld system parameters, such as voltage, current and wire feed rate, are also monitored and archived for correlation with quality parameters.

  6. Reliability analysis of shutdown system

    International Nuclear Information System (INIS)

    Kumar, C. Senthil; John Arul, A.; Pal Singh, Om; Suryaprakasa Rao, K.

    2005-01-01

    This paper presents the results of reliability analysis of Shutdown System (SDS) of Indian Prototype Fast Breeder Reactor. Reliability analysis carried out using Fault Tree Analysis predicts a value of 3.5 x 10 -8 /de for failure of shutdown function in case of global faults and 4.4 x 10 -8 /de for local faults. Based on 20 de/y, the frequency of shutdown function failure is 0.7 x 10 -6 /ry, which meets the reliability target, set by the Indian Atomic Energy Regulatory Board. The reliability is limited by Common Cause Failure (CCF) of actuation part of SDS and to a lesser extent CCF of electronic components. The failure frequency of individual systems is -3 /ry, which also meets the safety criteria. Uncertainty analysis indicates a maximum error factor of 5 for the top event unavailability

  7. Primary system boron dilution analysis

    International Nuclear Information System (INIS)

    Crump, R.J.; Naretto, C.J.; Borgen, R.A.; Rockhold, H.C.

    1978-01-01

    The results are presented for an analysis conducted to determine the potential paths through which nonborated water or water with insufficient boron concentration might enter the LOFT primary coolant piping system or reactor vessel to cause dilution of the borated primary coolant water. No attempt was made in the course of this analysis to identify possible design modifications nor to suggest changes in administrative procedures or controls

  8. Distribution system modeling and analysis

    CERN Document Server

    Kersting, William H

    2001-01-01

    For decades, distribution engineers did not have the sophisticated tools developed for analyzing transmission systems-often they had only their instincts. Things have changed, and we now have computer programs that allow engineers to simulate, analyze, and optimize distribution systems. Powerful as these programs are, however, without a real understanding of the operating characteristics of a distribution system, engineers using the programs can easily make serious errors in their designs and operating procedures. Distribution System Modeling and Analysis helps prevent those errors. It gives readers a basic understanding of the modeling and operating characteristics of the major components of a distribution system. One by one, the author develops and analyzes each component as a stand-alone element, then puts them all together to analyze a distribution system comprising the various shunt and series devices for power-flow and short-circuit studies. He includes the derivation of all models and includes many num...

  9. Key KdSOC1 gene expression profiles during plantlet morphogenesis under hormone, photoperiod, and drought treatments.

    Science.gov (United States)

    Liu, C; Zhu, C; Zeng, H M

    2016-02-11

    Kalanchoe daigremontiana utilizes plantlet formation between its zigzag leaf margins as its method of asexual reproduction. In this study, K. daigremontiana SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (KdSOC1), a key intermediate in the transition from vegetative to asexual growth, was cloned. Furthermore, its expression profiles during plantlet formation under different environmental and hormone induction conditions were analyzed. The full-KdSOC1 cDNA sequence length was 1410 bp with 70% shared homology with Carya cathayensis SOC1. The conserved domain search of KdSOC1 showed the absence of I and C domains, which might indicate novel biological functions in K. daigremontiana. The full-KdSOC1 promoter sequence was 1401 bp long and contained multiple-hormone-responsive cis-acting elements. Hormone induction assays showed that gibberellins and salicylic acid mainly regulated KdSOC1 expression. The swift change from low to high KdSOC1 expression levels during long-day induction was accompanied by the rapid emergence of plantlets. Drought stress stimulated KdSOC1 expression in leaves both with and without plantlet formation. Together, the results suggested that KdSOC1 was closely involved in environmental stimulation signal perception and the transduction of K. daigremontiana plantlet formation. Therefore, future identification of KdSOC1 functions might reveal key information that will help elucidate the transition network between embryogenesis and organogenesis during plantlet formation.

  10. Automated Loads Analysis System (ATLAS)

    Science.gov (United States)

    Gardner, Stephen; Frere, Scot; O’Reilly, Patrick

    2013-01-01

    ATLAS is a generalized solution that can be used for launch vehicles. ATLAS is used to produce modal transient analysis and quasi-static analysis results (i.e., accelerations, displacements, and forces) for the payload math models on a specific Shuttle Transport System (STS) flight using the shuttle math model and associated forcing functions. This innovation solves the problem of coupling of payload math models into a shuttle math model. It performs a transient loads analysis simulating liftoff, landing, and all flight events between liftoff and landing. ATLAS utilizes efficient and numerically stable algorithms available in MSC/NASTRAN.

  11. Systems analysis - independent analysis and verification

    Energy Technology Data Exchange (ETDEWEB)

    DiPietro, J.P.; Skolnik, E.G.; Badin, J.S. [Energetics, Inc., Columbia, MD (United States)

    1996-10-01

    The Hydrogen Program of the U.S. Department of Energy (DOE) funds a portfolio of activities ranging from conceptual research to pilot plant testing. The long-term research projects support DOE`s goal of a sustainable, domestically based energy system, and the development activities are focused on hydrogen-based energy systems that can be commercially viable in the near-term. Energetics develops analytic products that enable the Hydrogen Program Manager to assess the potential for near- and long-term R&D activities to satisfy DOE and energy market criteria. This work is based on a pathway analysis methodology. The authors consider an energy component (e.g., hydrogen production from biomass gasification, hybrid hydrogen internal combustion engine (ICE) vehicle) within a complete energy system. The work involves close interaction with the principal investigators to ensure accurate representation of the component technology. Comparisons are made with the current cost and performance of fossil-based and alternative renewable energy systems, and sensitivity analyses are conducted to determine the effect of changes in cost and performance parameters on the projects` viability.

  12. System analysis for radwaste management

    International Nuclear Information System (INIS)

    Lennemann, W.L.

    1987-01-01

    The most logical approach to evaluating radioactive waste management processes and their options is to consider radioactive waste management, handling, and disposal as a complete and complex system from the waste arisings to their disposition. The principal elements that should be considered or taken into account when making a decision involving one or more components of a radwaste management system essentially concern radiation doses or detriments- both radiological and industrial safety and both capital investments and operating costs. This paper discusses the system analysis of the low- and medium-level radioactive waste management

  13. One-chip Integrated Module of MEMS Shock Sensor and Sensing Amplifier LSI using Pseudo-SOC Technology

    Science.gov (United States)

    Iida, Atsuko; Onozuka, Yutaka; Nishigaki, Michihiko; Yamada, Hiroshi; Funaki, Hideyuki; Itaya, Kazuhiko

    We have been developing the pseudo-SOC technology for one-chip module integration of heterogeneous devices that realizes high electrical performance and high density of devices embodying the advantages of both SOC technology and SIP technology. Especially, this technology is available for MEMS-LSI integration. We developed a 0.2mm-thickness one-chip module integrating a MEMS shock sensor and a sensing amplifier LSI by applying this technology. The MEMS shock sensor and the sensing amplifier LSI were connected by high-rigidity epoxy resin optimized the material constants to reduce the stress and the warpage resulting from resin shrinkage due to curing. Then the planar insulating layer and the redistributed conducting layer were formed on it for the global layer. The MEMS shock sensor was preformed to be modularized with a glass cap. Electrical contacts were achieved by bonding of Au bumps on the MEMS fixed electrodes and via holes filled with Ag paste of the glass cap. Functional performance was confirmed by obtaining signal corresponding to the reference signal of the pick-up sensor. Furthermore, stress analysis was performed using the FEM model simulation considering the resin shrinkage.

  14. Radiographic enhancement and analysis system

    International Nuclear Information System (INIS)

    Schlosser, M.S.

    1981-01-01

    Radiographic image enhancement and analysis techniques are discussed as they apply to nondestructive inspection. A system is described which has been developed to enhance and quantitatively evaluate radiographic images using digital computer techniques. Some examples of typical applications are also presented as an introduction to this new inspection technique. (author)

  15. Automated activation-analysis system

    International Nuclear Information System (INIS)

    Minor, M.M.; Garcia, S.R.; Denton, M.M.

    1982-01-01

    An automated delayed neutron counting and instrumental neutron activation analysis system has been developed at Los Alamos National Laboratory's Omega West Reactor (OWR) to analyze samples for uranium and 31 additional elements with a maximum throughput of 400 samples per day

  16. Systems analysis and the computer

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, A S

    1983-08-01

    The words systems analysis are used in at least two senses. Whilst the general nature of the topic is well understood in the or community, the nature of the term as used by computer scientists is less familiar. In this paper, the nature of systems analysis as it relates to computer-based systems is examined from the point of view that the computer system is an automaton embedded in a human system, and some facets of this are explored. It is concluded that or analysts and computer analysts have things to learn from each other and that this ought to be reflected in their education. The important role played by change in the design of systems is also highlighted, and it is concluded that, whilst the application of techniques developed in the artificial intelligence field have considerable relevance to constructing automata able to adapt to change in the environment, study of the human factors affecting the overall systems within which the automata are embedded has an even more important role. 19 references.

  17. Soil Carbon Variability and Change Detection in the Forest Inventory Analysis Database of the United States

    Science.gov (United States)

    Wu, A. M.; Nater, E. A.; Dalzell, B. J.; Perry, C. H.

    2014-12-01

    The USDA Forest Service's Forest Inventory Analysis (FIA) program is a national effort assessing current forest resources to ensure sustainable management practices, to assist planning activities, and to report critical status and trends. For example, estimates of carbon stocks and stock change in FIA are reported as the official United States submission to the United Nations Framework Convention on Climate Change. While the main effort in FIA has been focused on aboveground biomass, soil is a critical component of this system. FIA sampled forest soils in the early 2000s and has remeasurement now underway. However, soil sampling is repeated on a 10-year interval (or longer), and it is uncertain what magnitude of changes in soil organic carbon (SOC) may be detectable with the current sampling protocol. We aim to identify the sensitivity and variability of SOC in the FIA database, and to determine the amount of SOC change that can be detected with the current sampling scheme. For this analysis, we attempt to answer the following questions: 1) What is the sensitivity (power) of SOC data in the current FIA database? 2) How does the minimum detectable change in forest SOC respond to changes in sampling intervals and/or sample point density? Soil samples in the FIA database represent 0-10 cm and 10-20 cm depth increments with a 10-year sampling interval. We are investigating the variability of SOC and its change over time for composite soil data in each FIA region (Pacific Northwest, Interior West, Northern, and Southern). To guide future sampling efforts, we are employing statistical power analysis to examine the minimum detectable change in SOC storage. We are also investigating the sensitivity of SOC storage changes under various scenarios of sample size and/or sample frequency. This research will inform the design of future FIA soil sampling schemes and improve the information available to international policy makers, university and industry partners, and the public.

  18. Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3 Function and Expression

    Directory of Open Access Journals (Sweden)

    Jamie J. L. Williams

    2014-05-01

    Full Text Available The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention by small molecule inhibitors and biologicals. In this review, we discuss JAK-STAT signalling pathway inhibition by the inducible inhibitor “suppressor of cytokine signaling 3 (SOCS3, its role in diseases such as myeloproliferative disorders, and its function as part of a multi-subunit E3 ubiquitin ligase complex. In addition, we highlight potential applications of these insights into SOCS3-based therapeutic strategies for management of conditions such as vascular re-stenosis associated with acute vascular injury, where there is strong evidence that multiple processes involved in disease progression could be attenuated by localized potentiation of SOCS3 expression levels.

  19. EpSoc: Social-Based Epidemic-Based Routing Protocol in Opportunistic Mobile Social Network

    Directory of Open Access Journals (Sweden)

    Halikul Lenando

    2018-01-01

    Full Text Available In opportunistic networks, the nature of intermittent and disruptive connections degrades the efficiency of routing. Epidemic routing protocol is used as a benchmark for most of routing protocols in opportunistic mobile social networks (OMSNs due to its high message delivery and latency. However, Epidemic incurs high cost in terms of overhead and hop count. In this paper, we propose a hybrid routing protocol called EpSoc which utilizes the Epidemic routing forwarding strategy and exploits an important social feature, that is, degree centrality. Two techniques are used in EpSoc. Messages’ TTL is adjusted based on the degree centrality of nodes, and the message blocking mechanism is used to control replication. Simulation results show that EpSoc increases the delivery ratio and decreases the overhead ratio, the average latency, and the hop counts as compared to Epidemic and Bubble Rap.

  20. A 10-bit 200-kS/s SAR ADC IP core for a touch screen SoC

    International Nuclear Information System (INIS)

    Tong Xingyuan; Yang Yintang; Zhu Zhangming; Sheng Wenfang

    2010-01-01

    Based on a 5 MSBs (most-significant-bits)-plus-5 LSBs (least-significant-bits) C-R hybrid D/A conversion and low-offset pseudo-differential comparison approach, with capacitor array axially symmetric layout topology and resistor string low gradient mismatch placement method, an 8-channel 10-bit 200-kS/s SAR ADC (successive-approximation-register analog-to-digital converter) IP core for a touch screen SoC (system-on-chip) is implemented in a 0.18 μm 1P5M CMOS logic process. Design considerations for the touch screen SAR ADC are included. With a 1.8 V power supply, the DNL (differential non-linearity) and INL (integral non-linearity) of this converter are measured to be about 0.32 LSB and 0.81 LSB respectively. With an input frequency of 91 kHz at 200-kS/s sampling rate, the spurious-free dynamic range and effective-number-of-bits are measured to be 63.2 dB and 9.15 bits respectively, and the power is about 136 μW. This converter occupies an area of about 0.08 mm 2 . The design results show that it is very suitable for touch screen SoC applications. (semiconductor integrated circuits)

  1. Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling.

    Science.gov (United States)

    Farquharson, Colin; Ahmed, S Faisal

    2013-04-01

    Linear bone growth is widely recognized to be adversely affected in children with chronic kidney disease (CKD) and other chronic inflammatory disorders. The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) pathway is anabolic to the skeleton and inflammatory cytokines compromise bone growth through a number of different mechanisms, which include interference with the systemic as well as the tissue-level GH/IGF-1 axis. Despite attempts to promote growth and control disease, there are an increasing number of reports of the persistence of poor growth in a substantial proportion of patients receiving rhGH and/or drugs that block cytokine action. Thus, there is an urgent need to consider better and alternative forms of therapy that are directed specifically at the mechanism of the insult which leads to abnormal bone health. Suppressor of cytokine signaling 2 (SOCS2) expression is increased in inflammatory conditions including CKD, and is a recognized inhibitor of GH signaling. Therefore, in this review, we will focus on the premise that SOCS2 signaling represents a critical pathway in growth plate chondrocytes through which pro-inflammatory cytokines alter both GH/IGF-1 signaling and cellular function.

  2. Postlingual deaf speech and the role of audition in speech production: comments on Waldstein's paper [R.S. Waldstein, J. Acoust. Soc. Am. 88, 2099-2114 (1990)].

    Science.gov (United States)

    Sapir, S; Canter, G J

    1991-09-01

    Using acoustic analysis techniques, Waldstein [J. Acoust. Soc. Am. 88, 2099-2114 (1990] reported abnormal speech findings in postlingual deaf speakers. She interpreted her findings to suggest that auditory feedback is important in motor speech control. However, it is argued here that Waldstein's interpretation may be unwarranted without addressing the possibility of neurologic deficits (e.g., dysarthria) as confounding (or even primary) causes of the abnormal speech in her subjects.

  3. Matching soil grid unit resolutions with polygon unit scales for DNDC modelling of regional SOC pool

    Science.gov (United States)

    Zhang, H. D.; Yu, D. S.; Ni, Y. L.; Zhang, L. M.; Shi, X. Z.

    2015-03-01

    Matching soil grid unit resolution with polygon unit map scale is important to minimize uncertainty of regional soil organic carbon (SOC) pool simulation as their strong influences on the uncertainty. A series of soil grid units at varying cell sizes were derived from soil polygon units at the six map scales of 1:50 000 (C5), 1:200 000 (D2), 1:500 000 (P5), 1:1 000 000 (N1), 1:4 000 000 (N4) and 1:14 000 000 (N14), respectively, in the Tai lake region of China. Both format soil units were used for regional SOC pool simulation with DeNitrification-DeComposition (DNDC) process-based model, which runs span the time period 1982 to 2000 at the six map scales, respectively. Four indices, soil type number (STN) and area (AREA), average SOC density (ASOCD) and total SOC stocks (SOCS) of surface paddy soils simulated with the DNDC, were attributed from all these soil polygon and grid units, respectively. Subjecting to the four index values (IV) from the parent polygon units, the variation of an index value (VIV, %) from the grid units was used to assess its dataset accuracy and redundancy, which reflects uncertainty in the simulation of SOC. Optimal soil grid unit resolutions were generated and suggested for the DNDC simulation of regional SOC pool, matching with soil polygon units map scales, respectively. With the optimal raster resolution the soil grid units dataset can hold the same accuracy as its parent polygon units dataset without any redundancy, when VIV indices was assumed as criteria to the assessment. An quadratic curve regression model y = -8.0 × 10-6x2 + 0.228x + 0.211 (R2 = 0.9994, p < 0.05) was revealed, which describes the relationship between optimal soil grid unit resolution (y, km) and soil polygon unit map scale (1:x). The knowledge may serve for grid partitioning of regions focused on the investigation and simulation of SOC pool dynamics at certain map scale.

  4. VIBRATION ISOLATION SYSTEM PROBABILITY ANALYSIS

    Directory of Open Access Journals (Sweden)

    Smirnov Vladimir Alexandrovich

    2012-10-01

    Full Text Available The article deals with the probability analysis for a vibration isolation system of high-precision equipment, which is extremely sensitive to low-frequency oscillations even of submicron amplitude. The external sources of low-frequency vibrations may include the natural city background or internal low-frequency sources inside buildings (pedestrian activity, HVAC. Taking Gauss distribution into account, the author estimates the probability of the relative displacement of the isolated mass being still lower than the vibration criteria. This problem is being solved in the three dimensional space, evolved by the system parameters, including damping and natural frequency. According to this probability distribution, the chance of exceeding the vibration criteria for a vibration isolation system is evaluated. Optimal system parameters - damping and natural frequency - are being developed, thus the possibility of exceeding vibration criteria VC-E and VC-D is assumed to be less than 0.04.

  5. A Human Body Analysis System

    Directory of Open Access Journals (Sweden)

    Girondel Vincent

    2006-01-01

    Full Text Available This paper describes a system for human body analysis (segmentation, tracking, face/hands localisation, posture recognition from a single view that is fast and completely automatic. The system first extracts low-level data and uses part of the data for high-level interpretation. It can detect and track several persons even if they merge or are completely occluded by another person from the camera's point of view. For the high-level interpretation step, static posture recognition is performed using a belief theory-based classifier. The belief theory is considered here as a new approach for performing posture recognition and classification using imprecise and/or conflicting data. Four different static postures are considered: standing, sitting, squatting, and lying. The aim of this paper is to give a global view and an evaluation of the performances of the entire system and to describe in detail each of its processing steps, whereas our previous publications focused on a single part of the system. The efficiency and the limits of the system have been highlighted on a database of more than fifty video sequences where a dozen different individuals appear. This system allows real-time processing and aims at monitoring elderly people in video surveillance applications or at the mixing of real and virtual worlds in ambient intelligence systems.

  6. The SOC in cells’ living expectations of Conway’s Game of Life and its extended version

    International Nuclear Information System (INIS)

    Wei, Jinling; Zhou, Haiyan; Meng, Jun; Zhang, Fan; Chen, Yunmo; Zhou, Su

    2016-01-01

    In self-organized systems such as Conway’s Game of Life (CGL). Wikipedia, Conway’s game of the life, (https://en.wikipedia.org/wiki/Conway%27s-Game-of-Life)., though whether the single cell will survive or die seems unpredictable, the log–log distribution of all cells living frequency satisfies the 1/f linear law, thus meets the Self-organized Criticality(SOC) rule, which not only proves that CGL is a self-organized system, but more significantly, that the chance of living for each cell is spatial heterogeneous, and is statistical fractal. After carried out CGL, the specified iterative period which begins with a random initial condition and ends when it reaches the homeostasis, add up all the states which the living cells are marked by 1s, and the dead are marked by 0s. The resulted sum picture consisting of cells having its gray level representing the living times during the iterative process. By plotting the gray level distribution of the sum picture on log–log scale, the graph indicates the spatial living expectations distributions. Then we find the curve of the graph satisfies the Self-organized Criticality(SOC) rule, showing its linear feature in the intermediate zone, which also has name of 1/f feature. To examine its universality, we designed a more complicated self-organized cellular automata with each cell having five possible states thus the rule table becomes more complicated. As expected, the consequence shows the similar feature, and the linear feature is even more obvious when the similar experiments are carried out. To conclude, it is a new discovery of SOC from a new perspective. And with the self-organized systems expanding to other different rule tables, this feature may still be satisfied. More further, considering the natural self-organized systems of living creatures, the spatial living expectations of different phenotypes may satisfy the 1/f law, too. Though we regard this as an inspirational orientation, the supposition needs more

  7. Novel electrical energy storage system based on reversible solid oxide cells: System design and operating conditions

    Science.gov (United States)

    Wendel, C. H.; Kazempoor, P.; Braun, R. J.

    2015-02-01

    Electrical energy storage (EES) is an important component of the future electric grid. Given that no other widely available technology meets all the EES requirements, reversible (or regenerative) solid oxide cells (ReSOCs) working in both fuel cell (power producing) and electrolysis (fuel producing) modes are envisioned as a technology capable of providing highly efficient and cost-effective EES. However, there are still many challenges and questions from cell materials development to system level operation of ReSOCs that should be addressed before widespread application. This paper presents a novel system based on ReSOCs that employ a thermal management strategy of promoting exothermic methanation within the ReSOC cell-stack to provide thermal energy for the endothermic steam/CO2 electrolysis reactions during charging mode (fuel producing). This approach also serves to enhance the energy density of the stored gases. Modeling and parametric analysis of an energy storage concept is performed using a physically based ReSOC stack model coupled with thermodynamic system component models. Results indicate that roundtrip efficiencies greater than 70% can be achieved at intermediate stack temperature (680 °C) and elevated stack pressure (20 bar). The optimal operating condition arises from a tradeoff between stack efficiency and auxiliary power requirements from balance of plant hardware.

  8. Systems analysis department annual progress report 1986

    International Nuclear Information System (INIS)

    Grohnheit, P.E.; Larsen, H.; Vestergaard, N.K.

    1987-02-01

    The report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1986. The activities may be classified as energy systems analysis and risk and reliability analysis. The report includes a list of staff members. (author)

  9. Applied systems analysis. No. 22

    International Nuclear Information System (INIS)

    1980-12-01

    Based on a detailed analysis of demands in the area Cologne/Frankfurt, the amount of the system products for this region were ascertained, which under consideration of technical conditions and entrepreneurial aspects seemed to be disposable at cost equality with competative energy supplies. Based on these data, the technical components of the system, location and piping were fixed and first- and operating costs were determined. For a judgement of the economics, the key numbers, cash value, internal rate of interest and cost recovery rate were determined from the difference of costs between the nuclear long distance energy system and alternative facilities. Furthermore specific production cost, associated prices and contribution margin were presented for each product. (orig.) [de

  10. Computational system for geostatistical analysis

    Directory of Open Access Journals (Sweden)

    Vendrusculo Laurimar Gonçalves

    2004-01-01

    Full Text Available Geostatistics identifies the spatial structure of variables representing several phenomena and its use is becoming more intense in agricultural activities. This paper describes a computer program, based on Windows Interfaces (Borland Delphi, which performs spatial analyses of datasets through geostatistic tools: Classical statistical calculations, average, cross- and directional semivariograms, simple kriging estimates and jackknifing calculations. A published dataset of soil Carbon and Nitrogen was used to validate the system. The system was useful for the geostatistical analysis process, for the manipulation of the computational routines in a MS-DOS environment. The Windows development approach allowed the user to model the semivariogram graphically with a major degree of interaction, functionality rarely available in similar programs. Given its characteristic of quick prototypation and simplicity when incorporating correlated routines, the Delphi environment presents the main advantage of permitting the evolution of this system.

  11. Film analysis systems and applications

    Energy Technology Data Exchange (ETDEWEB)

    Yonekura, Y.; Brill, A.B.

    1981-01-01

    The different components that can be used in modern film analysis systems are reviewed. TV camera and charge-coupled device sensors coupled to computers provide low cost systems for applications such as those described. The autoradiography (ARG) method provides an important tool for medical research and is especially useful for the development of new radiopharmaceutical compounds. Biodistribution information is needed for estimation of radiation dose, and for interpretation of the significance of observed patterns. The need for such precise information is heightened when one seeks to elucidate physiological principles/factors in normal and experimental models of disease. The poor spatial resolution achieved with current PET-imaging systems limits the information on radioreceptor mapping, neutrotransmitter, and neuroleptic drug distribution that can be achieved from patient studies. The artful use of ARG in carefully-controlled animal studies will be required to provide the additional information needed to fully understand results obtained with this new important research tool. (ERB)

  12. Film analysis systems and applications

    International Nuclear Information System (INIS)

    Yonekura, Y.; Brill, A.B.

    1981-01-01

    The different components that can be used in modern film analysis systems are reviewed. TV camera and charge-coupled device sensors coupled to computers provide low cost systems for applications such as those described. The autoradiography (ARG) method provides an important tool for medical research and is especially useful for the development of new radiopharmaceutical compounds. Biodistribution information is needed for estimation of radiation dose, and for interpretation of the significance of observed patterns. The need for such precise information is heightened when one seeks to elucidate physiological principles/factors in normal and experimental models of disease. The poor spatial resolution achieved with current PET-imaging systems limits the information on radioreceptor mapping, neutrotransmitter, and neuroleptic drug distribution that can be achieved from patient studies. The artful use of ARG in carefully-controlled animal studies will be required to provide the additional information needed to fully understand results obtained with this new important research tool

  13. E-CMIRC - towards a model for the integration of services between SOCs and CSIRTs

    CSIR Research Space (South Africa)

    Jacobs, P

    2015-07-01

    Full Text Available , including governments. While the focus of a SOC is on the monitoring of technical security controls and critical assets, and the response to attacks and threats, CSIRTs’ main focus is on response and incident management. One postulation is that a CSIRT...

  14. Computational model of 18650 lithium-ion battery with coupled strain rate and SOC dependencies

    International Nuclear Information System (INIS)

    Xu, Jun; Liu, Binghe; Wang, Xinyi; Hu, Dayong

    2016-01-01

    Highlights: • An anisotropic model to describe mechanical behaviors of LIB is established. • SOC dependency is included in the mechanical model of the jellyroll. • Dynamic effect is considered in the model for LIB. - Abstract: Highly nonlinear structures and constituent materials and hazardous experiment situations have resulted in a pressing need for a numerical mechanical model for lithium-ion battery (LIB). However, such a model is still not well established. In this paper, an anisotropic homogeneous model describing the jellyroll and the battery shell is established and validated through compression, indentation, and bending tests at quasi-static loadings. In this model, state-of-charge (SOC) dependency of the LIB is further included through an analogy with the strain-rate effect. Moreover, with consideration of the inertia and strain-rate effects, the anisotropic homogeneous model is extended into the dynamic regime and proven capable of predicting the dynamic response of the LIB using the drop-weight test. The established model may help to predict extreme cases with high SOCs and crashing speeds with an over 135% improved accuracy compared to traditional models. The established coupled strain rate and SOC dependencies of the numerical mechanical model for the LIB aims to provide a solid step toward unraveling and quantifying the complicated problems for research on LIB mechanical integrity.

  15. 3D integration for NoC-based SoC architectures

    CERN Document Server

    Sheibanyrad, Abbas; Pétrot, Frédéric

    2011-01-01

    3D-Integration for NoC-based SoC Architectures gathers the recent advances in the whole domain by renowned experts in the field to build a comprehensive and consistent book around the hot topics of three-dimensional architectures and micro-architectures.

  16. An overview of online implementable SOC estimation methods for Lithium-ion batteries

    DEFF Research Database (Denmark)

    Jinhao, Meng; Ricco, Mattia; Guangzhao, Luo

    2017-01-01

    With the popularity of Electrical Vehicles (EVs), Lithium-ion battery industry is also developing rapidly. To ensure the battery safety usage and reduce the average lifecycle cost, accurate State Of Charge (SOC) tracking algorithms for real-time implementation are required in different applications...

  17. An Overview and Comparison of Online Implementable SOC Estimation Methods for Lithium-ion Battery

    DEFF Research Database (Denmark)

    Meng, Jinhao; Ricco, Mattia; Luo, Guangzhao

    2018-01-01

    With the popularity of Electrical Vehicles (EVs), Lithium-ion battery industry is developing rapidly. To ensure the battery safe usage and to reduce its average lifecycle cost, an accurate State of Charge (SOC) tracking algorithms for real-time implementation are required for different applications...

  18. Automation for System Safety Analysis

    Science.gov (United States)

    Malin, Jane T.; Fleming, Land; Throop, David; Thronesbery, Carroll; Flores, Joshua; Bennett, Ted; Wennberg, Paul

    2009-01-01

    This presentation describes work to integrate a set of tools to support early model-based analysis of failures and hazards due to system-software interactions. The tools perform and assist analysts in the following tasks: 1) extract model parts from text for architecture and safety/hazard models; 2) combine the parts with library information to develop the models for visualization and analysis; 3) perform graph analysis and simulation to identify and evaluate possible paths from hazard sources to vulnerable entities and functions, in nominal and anomalous system-software configurations and scenarios; and 4) identify resulting candidate scenarios for software integration testing. There has been significant technical progress in model extraction from Orion program text sources, architecture model derivation (components and connections) and documentation of extraction sources. Models have been derived from Internal Interface Requirements Documents (IIRDs) and FMEA documents. Linguistic text processing is used to extract model parts and relationships, and the Aerospace Ontology also aids automated model development from the extracted information. Visualizations of these models assist analysts in requirements overview and in checking consistency and completeness.

  19. The ATLAS distributed analysis system

    International Nuclear Information System (INIS)

    Legger, F

    2014-01-01

    In the LHC operations era, analysis of the multi-petabyte ATLAS data sample by globally distributed physicists is a challenging task. To attain the required scale the ATLAS Computing Model was designed around the concept of Grid computing, realized in the Worldwide LHC Computing Grid (WLCG), the largest distributed computational resource existing in the sciences. The ATLAS experiment currently stores over 140 PB of data and runs about 140,000 concurrent jobs continuously at WLCG sites. During the first run of the LHC, the ATLAS Distributed Analysis (DA) service has operated stably and scaled as planned. More than 1600 users submitted jobs in 2012, with 2 million or more analysis jobs per week, peaking at about a million jobs per day. The system dynamically distributes popular data to expedite processing and maximally utilize resources. The reliability of the DA service is high and steadily improving; Grid sites are continually validated against a set of standard tests, and a dedicated team of expert shifters provides user support and communicates user problems to the sites. Both the user support techniques and the direct feedback of users have been effective in improving the success rate and user experience when utilizing the distributed computing environment. In this contribution a description of the main components, activities and achievements of ATLAS distributed analysis is given. Several future improvements being undertaken will be described.

  20. The ATLAS distributed analysis system

    Science.gov (United States)

    Legger, F.; Atlas Collaboration

    2014-06-01

    In the LHC operations era, analysis of the multi-petabyte ATLAS data sample by globally distributed physicists is a challenging task. To attain the required scale the ATLAS Computing Model was designed around the concept of Grid computing, realized in the Worldwide LHC Computing Grid (WLCG), the largest distributed computational resource existing in the sciences. The ATLAS experiment currently stores over 140 PB of data and runs about 140,000 concurrent jobs continuously at WLCG sites. During the first run of the LHC, the ATLAS Distributed Analysis (DA) service has operated stably and scaled as planned. More than 1600 users submitted jobs in 2012, with 2 million or more analysis jobs per week, peaking at about a million jobs per day. The system dynamically distributes popular data to expedite processing and maximally utilize resources. The reliability of the DA service is high and steadily improving; Grid sites are continually validated against a set of standard tests, and a dedicated team of expert shifters provides user support and communicates user problems to the sites. Both the user support techniques and the direct feedback of users have been effective in improving the success rate and user experience when utilizing the distributed computing environment. In this contribution a description of the main components, activities and achievements of ATLAS distributed analysis is given. Several future improvements being undertaken will be described.

  1. Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells.

    Science.gov (United States)

    Xiong, Hua; Du, Wan; Zhang, Yan-Jie; Hong, Jie; Su, Wen-Yu; Tang, Jie-Ting; Wang, Ying-Chao; Lu, Rong; Fang, Jing-Yuan

    2012-02-01

    Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2-containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulators of JAK/STAT signaling, have been reported to have tumor suppressor functions. However, in colorectal cancer (CRC) cells, the mechanisms that regulate SOCS and SHP1 genes, and the cause of abnormalities in the JAK/STAT signaling pathway, remain largely unknown. The present study shows that trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, leads to the hyperacetylation of histones associated with the SOCS1 and SOCS3 promoters, but not the SHP1 promoter in CRC cells. This indicates that histone modifications are involved in the regulation of SOCS1 and SOCS3. Moreover, upregulation of SOCS1 and SOCS3 expression was achieved using TSA, which also significantly downregulated JAK2/STAT3 signaling in CRC cells. We also demonstrate that TSA suppresses the growth of CRC cells, and induces G1 cell cycle arrest and apoptosis through the regulation of downstream targets of JAK2/STAT3 signaling, including Bcl-2, survivin and p16(ink4a) . Therefore, our data demonstrate that TSA may induce SOCS1 and SOCS3 expression by inducing histone modifications and consequently inhibits JAK2/STAT3 signaling in CRC cells. These results also establish a mechanistic link between the inhibition of JAK2/STAT3 signaling and the anticancer action of TSA in CRC cells. Copyright © 2011 Wiley Periodicals, Inc.

  2. Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase

    DEFF Research Database (Denmark)

    Zadjali, Fahad; Pike, Ashley C W; Vesterlund, Mattias

    2011-01-01

    to substrate residue position pY+6 and envelopes the c-KIT phosphopeptide with a large BG loop insertion that contributes significantly to substrate interaction. We demonstrate that SOCS6 has ubiquitin ligase activity toward c-KIT and regulates c-KIT protein turnover in cells. Our data support a role of SOCS6...

  3. X-ray system analysis

    International Nuclear Information System (INIS)

    Shapiro, J.S.

    1985-01-01

    An X-ray system tester for measuring anode voltage, cathode voltage, anode current, filament current and line voltage in an X-ray system has a selector which couples one of these analog signals or one of a plurality of processing control signals entered by an operator from a control panel to a digitizing section selectively in accordance with control signals provided to the selector by a computing section. The digitizing section converts the selected signal into a train of pulses having a frequency proportional to the value of the selected signal. These pulses are counted, the counts being used by the computing section to determine the value of the selected signal. This computed value is stored in a computing memory section of the computing section. The computing section is adapted to store a plurality of the sets of signals produced during a corresponding sequence of operational intervals of the X-ray system and determines a measure of the deviation of any selected one of the stored electrical signals over the sequence of operating intervals. Each signal produced during the sequential operational intervals can be recalled to aid analysis of the operation of the X-ray system. (author)

  4. Integrated minicomputer alpha analysis system

    International Nuclear Information System (INIS)

    Vasilik, D.G.; Coy, D.E.; Seamons, M.; Henderson, R.W.; Romero, L.L.; Thomson, D.A.

    1978-01-01

    Approximately 1,000 stack and occupation air samples from plutonium and uranium facilities at LASL are analyzed daily. The concentrations of radio-nuclides in air are determined by measuring absolute alpha activities of particulates collected on air sample filter media. The Integrated Minicomputer Pulse system (IMPULSE) is an interface between many detectors of extremely simple design and a Digital Equipment Corporation (DEC) PDP-11/04 minicomputer. The detectors are photomultiplier tubes faced with zinc sulfide (ZnS). The average detector background is approximately 0.07 cpm. The IMPULSE system includes two mainframes, each of which can hold up to 64 detectors. The current hardware configuration includes 64 detectors in one mainframe and 40 detectors in the other. Each mainframe contains a minicomputer with 28K words of Random Access Memory. One minicomputer controls the detectors in both mainframes. A second computer was added for fail-safe redundancy and to support other laboratory computer requirements. The main minicomputer includes a dual floppy disk system and a dual DEC 'RK05' disk system for mass storage. The RK05 facilitates report generation and trend analysis. The IMPULSE hardware provides for passage of data from the detectors to the computer, and for passage of status and control information from the computer to the detector stations

  5. System Engineering Analysis of Squadron Officer College

    Science.gov (United States)

    2012-03-01

    study identified five challenges to converting to a blended learning course. The greatest challenge is getting commitment and buy -in from senior...students thru the Army and Air Force Exchange Service (AAFES) snack bar. Managers are responsible for ensuring adequate support throughout the...Administration Function The administration function allows daily tasks to operate. SOC administration functions include providing students with

  6. The ATLAS Distributed Analysis System

    CERN Document Server

    Legger, F; The ATLAS collaboration; Pacheco Pages, A; Stradling, A

    2013-01-01

    In the LHC operations era, analysis of the multi-petabyte ATLAS data sample by globally distributed physicists is a challenging task. To attain the required scale the ATLAS Computing Model was designed around the concept of grid computing, realized in the Worldwide LHC Computing Grid (WLCG), the largest distributed computational resource existing in the sciences. The ATLAS experiment currently stores over 140 PB of data and runs about 140,000 concurrent jobs continuously at WLCG sites. During the first run of the LHC, the ATLAS Distributed Analysis (DA) service has operated stably and scaled as planned. More than 1600 users submitted jobs in 2012, with 2 million or more analysis jobs per week, peaking at about a million jobs per day. The system dynamically distributes popular data to expedite processing and maximally utilize resources. The reliability of the DA service is high but steadily improving; grid sites are continually validated against a set of standard tests, and a dedicated team of expert shifters ...

  7. The ATLAS Distributed Analysis System

    CERN Document Server

    Legger, F; The ATLAS collaboration

    2014-01-01

    In the LHC operations era, analysis of the multi-petabyte ATLAS data sample by globally distributed physicists is a challenging task. To attain the required scale the ATLAS Computing Model was designed around the concept of grid computing, realized in the Worldwide LHC Computing Grid (WLCG), the largest distributed computational resource existing in the sciences. The ATLAS experiment currently stores over 140 PB of data and runs about 140,000 concurrent jobs continuously at WLCG sites. During the first run of the LHC, the ATLAS Distributed Analysis (DA) service has operated stably and scaled as planned. More than 1600 users submitted jobs in 2012, with 2 million or more analysis jobs per week, peaking at about a million jobs per day. The system dynamically distributes popular data to expedite processing and maximally utilize resources. The reliability of the DA service is high but steadily improving; grid sites are continually validated against a set of standard tests, and a dedicated team of expert shifters ...

  8. Mapping SOC (Soil Organic Carbon) using LiDAR-derived vegetation indices in a random forest regression model

    Science.gov (United States)

    Will, R. M.; Glenn, N. F.; Benner, S. G.; Pierce, J. L.; Spaete, L.; Li, A.

    2015-12-01

    Quantifying SOC (Soil Organic Carbon) storage in complex terrain is challenging due to high spatial variability. Generally, the challenge is met by transforming point data to the entire landscape using surrogate, spatially-distributed, variables like elevation or precipitation. In many ecosystems, remotely sensed information on above-ground vegetation (e.g. NDVI) is a good predictor of below-ground carbon stocks. In this project, we are attempting to improve this predictive method by incorporating LiDAR-derived vegetation indices. LiDAR provides a mechanism for improved characterization of aboveground vegetation by providing structural parameters such as vegetation height and biomass. In this study, a random forest model is used to predict SOC using a suite of LiDAR-derived vegetation indices as predictor variables. The Reynolds Creek Experimental Watershed (RCEW) is an ideal location for a study of this type since it encompasses a strong elevation/precipitation gradient that supports lower biomass sagebrush ecosystems at low elevations and forests with more biomass at higher elevations. Sagebrush ecosystems composed of Wyoming, Low and Mountain Sagebrush have SOC values ranging from .4 to 1% (top 30 cm), while higher biomass ecosystems composed of aspen, juniper and fir have SOC values approaching 4% (top 30 cm). Large differences in SOC have been observed between canopy and interspace locations and high resolution vegetation information is likely to explain plot scale variability in SOC. Mapping of the SOC reservoir will help identify underlying controls on SOC distribution and provide insight into which processes are most important in determining SOC in semi-arid mountainous regions. In addition, airborne LiDAR has the potential to characterize vegetation communities at a high resolution and could be a tool for improving estimates of SOC at larger scales.

  9. 'RECASS'. Radioecological analysis support system

    International Nuclear Information System (INIS)

    Shershakov, V.

    1998-01-01

    The RECASS is developed as a computer system designed for radiation monitoring and decision-making support in a nuclear emergency. The RECASS system has excellent capabilities for collecting, storing, and presenting data from the radiological situation of contaminated areas. It is well designed for modeling radionuclide migration in the environmental media and for assessing countermeasures in terms of doses received by population groups as a result of radioactive contamination. For RECASS to be used as a basis for solving the problems of radioecological analysis, it is essential that mapping facilities are provided and that scaling capabilities allow data to be presented with the necessary degree of detail and accuracy. Because of the on-line links with the operating network of radiological monitoring, RECASS is capable of collecting meteorological and radiological data from across the country and storing this information in its databases. The availability of data from the network of radiological monitoring makes it possible to develop RECASS as a real-time emergency response system. (R.P.)

  10. A method for the densification of ceramic layers, especially ceramic layers within solid oxide cell (SOC) technology, and products obtained by the method

    DEFF Research Database (Denmark)

    2013-01-01

    A ceramic layer, especially for use in solid oxide cell (SOC) technology, is densified in a method comprising (a) providing a multilayer system by depositing the porous ceramic layer, which is to be densified, onto the selected system of ceramic layers on a support, (b) pre-sintering the resulting......(s) in the porous layer surface and (e) performing a thermal treatment at a temperature T2, where T2 > ?1, to obtain densification of and grain growth in the porous layer formed in step (b). The method makes it possible to obtain dense ceramic layers at temperatures, which are compatible with the other materials...... present in a ceramic multilayer system....

  11. System for the analysis of plant chromosomes

    International Nuclear Information System (INIS)

    Medina Martin, D.; Peraza Gonzalez, L.H.

    1996-01-01

    The paper describes a computer system for the automation workers of recognition analysis and interpretation of plant chromosomes. This system permit to carry out the analysis in a more comfortable and faster way, using the image processing techniques

  12. Substitution dynamical systems spectral analysis

    CERN Document Server

    Queffélec, Martine

    2010-01-01

    This volume mainly deals with the dynamics of finitely valued sequences, and more specifically, of sequences generated by substitutions and automata. Those sequences demonstrate fairly simple combinatorical and arithmetical properties and naturally appear in various domains. As the title suggests, the aim of the initial version of this book was the spectral study of the associated dynamical systems: the first chapters consisted in a detailed introduction to the mathematical notions involved, and the description of the spectral invariants followed in the closing chapters. This approach, combined with new material added to the new edition, results in a nearly self-contained book on the subject. New tools - which have also proven helpful in other contexts - had to be developed for this study. Moreover, its findings can be concretely applied, the method providing an algorithm to exhibit the spectral measures and the spectral multiplicity, as is demonstrated in several examples. Beyond this advanced analysis, many...

  13. Research on SEU hardening of heterogeneous Dual-Core SoC

    Science.gov (United States)

    Huang, Kun; Hu, Keliu; Deng, Jun; Zhang, Tao

    2017-08-01

    The implementation of Single-Event Upsets (SEU) hardening has various schemes. However, some of them require a lot of human, material and financial resources. This paper proposes an easy scheme on SEU hardening for Heterogeneous Dual-core SoC (HD SoC) which contains three techniques. First, the automatic Triple Modular Redundancy (TMR) technique is adopted to harden the register heaps of the processor and the instruction-fetching module. Second, Hamming codes are used to harden the random access memory (RAM). Last, a software signature technique is applied to check the programs which are running on CPU. The scheme need not to consume additional resources, and has little influence on the performance of CPU. These technologies are very mature, easy to implement and needs low cost. According to the simulation result, the scheme can satisfy the basic demand of SEU-hardening.

  14. Functional SOCS1 polymorphisms are associated with variation in obesity in whites

    DEFF Research Database (Denmark)

    Gylvin, T; Ek, J; Nolsøe, R.

    2009-01-01

    . A total of more than 8100 individuals were genotyped. RESULTS: Eight variations were identified in the 5' untranslated region (UTR) region. Two of these had allele frequencies below 1% and were not further examined. The six other variants were analysed in groups of T1D families (n = 1461 subjects) and T2D...... of both the rs33977706 and the rs243330 (-1656G > A) variants to obesity were found (p = 0.047 and p = 0.015) respectively. The rs33977706 affected both binding of a nuclear protein to and the transcriptional activity of the SOCS1 promoter, indicating a relationship between this polymorphism and gene...... regulation. CONCLUSIONS/INTERPRETATION: This study demonstrates that functional variations in the SOCS1 promoter may associate with alterations in BMI in the general white population....

  15. Universal interface on Zynq{sup ®} SoC with CAN, RS-232, Ethernet and AXI GPIO for instrumentation & control

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Abhijeet, E-mail: akumar@ipr.res.in; Rajpal, Rachana; Pujara, Harshad; Mandaliya, Hitesh; Edappala, Praveenalal

    2016-11-15

    Highlights: • We have designed Universal Interface on Zynq{sup ®} SoC with CAN, RS-232, Ethernet and AXI GPIO for Instrumentation & Control. This project is based on Zynq{sup ®}-7000 family xc7z020clg484-1 chip. • We explored the full design flow starting from the hardware development in Vivado to software development in SDK using APIs in C language and then interfacing the host application developed in LabVIEW. • We also explored how to make custom IP with AXI bus interface in Vivado. • Useful for those who wants to make custom hardware on Zynq{sup ®} SoC. - Abstract: This paper describes an application developed on the latest Zynq{sup ®}-7000 All Programmable SoC (AP SoC) [1] devices which integrate the software programmability of an ARM{sup ®}-based processor with the hardware programmability of an FPGA, on a single device. In this paper we have implemented application which uses various interfaces like CAN, RS-232, Ethernet and AXI GPIO, so that our host application running on PC in LabVIEW can communicates with any hardware which has at least any one of the available interface. Zynq-7000 All Programmable SoCs (System On Chip) infuse customizable intelligence into today’s embedded systems to suit your unique application requirements. This family of FPGA is meant for high end application because it has huge resources on single chip. It offers you to make your own custom hardware IP, in fact we have made our custom IP called myIP in our design. The beauty of this chip is that it can write drivers for your custom IP which has AXI bus layer attached. After exporting the hardware information to the Software Development Kit (SDK), the tool is able to write drivers for your custom IP. This simplifies your development to a great extent. In a way this application provides the universal interfacing option to user. User can also write the digital data on the GPIO (General Purpose Input Output) through LabVIEW Test application GUI. This project can be used

  16. Digital approach for the design of statistical analog data acquisition on SoCs

    OpenAIRE

    Adao Antonio de Souza Junior

    2005-01-01

    With the current demand for mixed-signal SoCs, an increasing number of designers are looking for ADC architectures that can be easily implemented over digital substrates. Since ADC performance is strongly dependent upon physical and electrical features, it gets more difficult for them to benefit from more recent technologies, where these features are more variable. This way, analog signal acquisition is not allowed to follow an evolutionary trend compatible with Moore’s Law. In fact, such tre...

  17. An improved PNGV modeling and SOC estimation for lithium iron phosphate batteries

    Science.gov (United States)

    Li, Peng

    2017-11-01

    Because lithium iron phosphate battery has many advantages, it has been used more and more widely in the field of electric vehicle. The lithium iron phosphate battery, presents the improved PNGV model, and the batteries charge discharge characteristics and pulse charge discharge experiments, identification of parameters of the battery model by interpolation and least square fitting method, to achieve a more accurate modeling of lithium iron phosphate battery, and the extended Calman filter algorithm (EKF) is completed state nuclear power battery (SOC) estimate.

  18. Transport-distance specific SOC distribution: Does it skew erosion induced C fluxes?

    DEFF Research Database (Denmark)

    Hu, Yaxian; Berbe, Asmerat Asefaw; Fogel, Marilyn L.

    2016-01-01

    Abstract The net effect of soil erosion by water, as a sink or source of atmospheric carbon dioxide (CO2), is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC), and the dynamic replacement of eroded C by the production of new photosynthate. The depositi......Abstract The net effect of soil erosion by water, as a sink or source of atmospheric carbon dioxide (CO2), is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC), and the dynamic replacement of eroded C by the production of new photosynthate...... the actual movement of eroded soil fractions along hillslopes, let alone the re-distribution pattern of SOC fractions. Eroding sandy soils and sediment were sampled after a series of rainfall events along a slope on a freshly seeded cropland in Jutland, Denmark. All the soil samples were fractionated...... into five settling classes using a settling tube apparatus. The spatial distribution of soil settling classes shows a coarsening effect immediately below the eroding slope, followed by a fining trend at the slope tail. These findings support the validity of the conceptual model proposed by Starr et al...

  19. Total Analysis System for Ship Structural Strength

    OpenAIRE

    Takuya, Yoneya; Hiroyuki, Kobayashi; Abdul M., Rahim; Yoshimichi, Sasaki; Masaki, Irisawa; Technical Investigation and Information Department, Research Center; Technical Investigation and Information Department, Research Center; Singapore Office; Technical Investigation and Information Department, Research Center; Technical Investigation and Information Department, Research Center

    2001-01-01

    This paper outlines a total analysis system for ship hull structures, which integrates a wide variety of analysis functions to realise practical applications of rational methods for assessing ship structural strength. It is based on direct calculation of wave-induced loads as well as three-dimensional structural analysis of an entire-ship or hold structure. Three major analysis functions of the total system are ship motion and wave load analysis, ship structural analysis and statistical analy...

  20. Tank waste remediation system mission analysis report

    International Nuclear Information System (INIS)

    Acree, C.D.

    1998-01-01

    The Tank Waste Remediation System Mission Analysis Report identifies the initial states of the system and the desired final states of the system. The Mission Analysis Report identifies target measures of success appropriate to program-level accomplishments. It also identifies program-level requirements and major system boundaries and interfaces

  1. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules.

    Directory of Open Access Journals (Sweden)

    Takanobu Nagata

    Full Text Available Myocardial ischemia reperfusion injury (IRI adversely affects cardiac performance and the prognosis of patients with acute myocardial infarction. Although myocardial signal transducer and activator of transcription (STAT 3 is potently cardioprotective during IRI, the inhibitory mechanism responsible for its activation is largely unknown. The present study aimed to investigate the role of the myocardial suppressor of cytokine signaling (SOCS-3, an intrinsic negative feedback regulator of the Janus kinase (JAK-STAT signaling pathway, in the development of myocardial IRI. Myocardial IRI was induced in mice by ligating the left anterior descending coronary artery for 1 h, followed by different reperfusion times. One hour after reperfusion, the rapid expression of JAK-STAT-activating cytokines was observed. We precisely evaluated the phosphorylation of cardioprotective signaling molecules and the expression of SOCS3 during IRI and then induced myocardial IRI in wild-type and cardiac-specific SOCS3 knockout mice (SOCS3-CKO. The activation of STAT3, AKT, and ERK1/2 rapidly peaked and promptly decreased during IRI. This decrease correlated with the induction of SOCS3 expression up to 24 h after IRI in wild-type mice. The infarct size 24 h after reperfusion was significantly reduced in SOCS3-CKO compared with wild-type mice. In SOCS3-CKO mice, STAT3, AKT, and ERK1/2 phosphorylation was sustained, myocardial apoptosis was prevented, and the expression of anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1 was augmented. Cardiac-specific SOCS3 deletion led to the sustained activation of cardioprotective signaling molecules including and prevented myocardial apoptosis and injury during IRI. Our findings suggest that SOCS3 may represent a key factor that exacerbates the development of myocardial IRI.

  2. Performance analysis of general purpose and digital signal processor kernels for heterogeneous systems-on-chip

    Directory of Open Access Journals (Sweden)

    T. von Sydow

    2003-01-01

    Full Text Available Various reasons like technology progress, flexibility demands, shortened product cycle time and shortened time to market have brought up the possibility and necessity to integrate different architecture blocks on one heterogeneous System-on-Chip (SoC. Architecture blocks like programmable processor cores (DSP- and GPP-kernels, embedded FPGAs as well as dedicated macros will be integral parts of such a SoC. Especially programmable architecture blocks and associated optimization techniques are discussed in this contribution. Design space exploration and thus the choice which architecture blocks should be integrated in a SoC is a challenging task. Crucial to this exploration is the evaluation of the application domain characteristics and the costs caused by individual architecture blocks integrated on a SoC. An ATE-cost function has been applied to examine the performance of the aforementioned programmable architecture blocks. Therefore, representative discrete devices have been analyzed. Furthermore, several architecture dependent optimization steps and their effects on the cost ratios are presented.

  3. Preliminary Electrochemical Characterization of Anode Supported Solid Oxide Cell (AS-SOC) Produced in the Institute of Power Engineering Operated in Electrolysis Mode (SOEC)

    Science.gov (United States)

    Kupecki, Jakub; Motyliński, Konrad; Skrzypkiewicz, Marek; Wierzbicki, Michał; Naumovich, Yevgeniy

    2017-12-01

    The article discusses the operation of solid oxide electrochemical cells (SOC) developed in the Institute of Power Engineering as prospective key components of power-to-gas systems. The fundamentals of the solid oxide cells operated as fuel cells (SOFC - solid oxide fuel cells) and electrolysers (SOEC - solid oxide fuel cells) are given. The experimental technique used for electrochemical characterization of cells is presented. The results obtained for planar cell with anodic support are given and discussed. Based on the results, the applicability of the cells in power-to-gas systems (P2G) is evaluated.

  4. Suppressor of cytokine signaling 2 (SOCS2) deletion protects against multiple low dose streptozotocin-induced type 1 diabetes in adult male mice

    DEFF Research Database (Denmark)

    Alkharusi, Amira; Mirecki-Garrido, Mercedes; Ma, Zuheng

    2016-01-01

    Background: Diabetes type 1 is characterized by the failure of beta cells to produce insulin. Suppressor of cytokine signaling (SOCS) proteins are important regulators of the Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway. Previous studies have shown that GH can...... prevent the development of type I diabetes in mice and that SOCS2 deficiency mimics a state of increased GH sensitivity. Methodology: The elevated sensitivity of SOCS2-/- mice to GH and possibly to PRL was the rationale to analyze the effects of multiple low dose streptozotocin (MLDSTZ)-induced diabetes...... in SOCS2-/- mice. Results: We show that 6-month-old SOCS2-/- mice, but not 2-month-old mice, were less sensitive to MLDSTZ-induced diabetes, compared to controls. MLDSTZ treatment induced glucose intolerance in both SOCS2+/+ and SOCS2-/- mice, as shown by glucose tolerance tests, with SOCS2+/+ mice...

  5. Power and Thermal Management of System-on-Chip

    DEFF Research Database (Denmark)

    Liu, Wei

    , are necessary at the chip design level. In this work, we investigate the power and thermal management of System-on- Chips (SoCs). Thermal analysis is performed in a SPICE simulation approach based on the electrical-thermal analogy. We investigate the impact of inter- connects on heat distribution...

  6. ADVANCED POWER SYSTEMS ANALYSIS TOOLS

    Energy Technology Data Exchange (ETDEWEB)

    Robert R. Jensen; Steven A. Benson; Jason D. Laumb

    2001-08-31

    The use of Energy and Environmental Research Center (EERC) modeling tools and improved analytical methods has provided key information in optimizing advanced power system design and operating conditions for efficiency, producing minimal air pollutant emissions and utilizing a wide range of fossil fuel properties. This project was divided into four tasks: the demonstration of the ash transformation model, upgrading spreadsheet tools, enhancements to analytical capabilities using the scanning electron microscopy (SEM), and improvements to the slag viscosity model. The ash transformation model, Atran, was used to predict the size and composition of ash particles, which has a major impact on the fate of the combustion system. To optimize Atran key factors such as mineral fragmentation and coalescence, the heterogeneous and homogeneous interaction of the organically associated elements must be considered as they are applied to the operating conditions. The resulting model's ash composition compares favorably to measured results. Enhancements to existing EERC spreadsheet application included upgrading interactive spreadsheets to calculate the thermodynamic properties for fuels, reactants, products, and steam with Newton Raphson algorithms to perform calculations on mass, energy, and elemental balances, isentropic expansion of steam, and gasifier equilibrium conditions. Derivative calculations can be performed to estimate fuel heating values, adiabatic flame temperatures, emission factors, comparative fuel costs, and per-unit carbon taxes from fuel analyses. Using state-of-the-art computer-controlled scanning electron microscopes and associated microanalysis systems, a method to determine viscosity using the incorporation of grey-scale binning acquired by the SEM image was developed. The image analysis capabilities of a backscattered electron image can be subdivided into various grey-scale ranges that can be analyzed separately. Since the grey scale's intensity

  7. Plasma data analysis using statistical analysis system

    International Nuclear Information System (INIS)

    Yoshida, Z.; Iwata, Y.; Fukuda, Y.; Inoue, N.

    1987-01-01

    Multivariate factor analysis has been applied to a plasma data base of REPUTE-1. The characteristics of the reverse field pinch plasma in REPUTE-1 are shown to be explained by four independent parameters which are described in the report. The well known scaling laws F/sub chi/ proportional to I/sub p/, T/sub e/ proportional to I/sub p/, and tau/sub E/ proportional to N/sub e/ are also confirmed. 4 refs., 8 figs., 1 tab

  8. PWR auxiliary systems, safety and emergency systems, accident analysis, operation

    International Nuclear Information System (INIS)

    Meyer, P.J.

    1976-01-01

    The author presents a description of PWR auxiliary systems like volume control, boric acid control, coolant purification, -degassing, -storage and -treatment system and waste processing systems. Residual heat removal systems, emergency systems and containment designs are discussed. As an accident analysis the author gives a survey over malfunctions and disturbances in the field of reactor operations. (TK) [de

  9. Straw incorporation increases crop yield and soil organic carbon sequestration but varies under different natural conditions and farming practices in China: a system analysis

    OpenAIRE

    Han, Xiao; Xu, Cong; Dungait, Jennifer A. J.; Bol, Roland; Wang, Xiaojie; Wu, Wenliang; Meng, Fanqiao

    2018-01-01

    Loss of soil organic carbon (SOC) from agricultural soils is a key indicator of soil degradation associated with reductions in net primary productivity in crop production systems worldwide. Technically simple and locally appropriate solutions are required for farmers to increase SOC and to improve cropland management. In the last 30 years, straw incorporation (SI) has gradually been implemented across China in the context of agricultural intensification and rural liveliho...

  10. Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus.

    Science.gov (United States)

    Strebovsky, Julia; Walker, Patrick; Lang, Roland; Dalpke, Alexander H

    2011-03-01

    Suppressor of cytokine signaling (SOCS) proteins are inhibitors of cytoplasmic Janus kinases (Jak) and signal transducer and activator of transcription (STAT) signaling pathways. Previously the authors surprisingly observed that SOCS1 translocated into the nucleus, which was because of the presence of a nuclear localization sequence. This report now hypothesizes that SOCS1 mediates specific functions within the nuclear compartment because it is instantly transported into the nucleus, as shown by photoactivation and live cell imaging in human HEK293 cells. The NFκB component p65 is identified as an interaction partner for SOCS1 but not for other members of the SOCS family. SOCS1 bound to p65 only within the nucleus. By means of its SOCS box domain, SOCS1 operated as a ubiquitin ligase, leading to polyubiquitination and proteasomal degradation of nuclear p65. Thus, SOCS1 limited prolonged p65 signaling and terminated expression of NFκB inducible genes. Using mutants that lack either nuclear translocation or a functional SOCS box, this report identifies genes that are regulated in a manner dependent on the nuclear availability of SOCS1. Data show that beyond its receptor-proximal function in Jak/STAT signaling, SOCS1 also regulates the duration of NFκB signaling within the cell nucleus, thus exerting a heretofore unrecognized function.

  11. Implementation of a wireless ECG acquisition SoC for IEEE 802.15.4 (ZigBee) applications.

    Science.gov (United States)

    Wang, Liang-Hung; Chen, Tsung-Yen; Lin, Kuang-Hao; Fang, Qiang; Lee, Shuenn-Yuh

    2015-01-01

    This paper presents a wireless biosignal acquisition system-on-a-chip (WBSA-SoC) specialized for electrocardiogram (ECG) monitoring. The proposed system consists of three subsystems, namely, 1) the ECG acquisition node, 2) the protocol for standard IEEE 802.15.4 ZigBee system, and 3) the RF transmitter circuits. The ZigBee protocol is adopted for wireless communication to achieve high integration, applicability, and portability. A fully integrated CMOS RF front end containing a quadrature voltage-controlled oscillator and a 2.4-GHz low-IF (i.e., zero-IF) transmitter is employed to transmit ECG signals through wireless communication. The low-power WBSA-SoC is implemented by the TSMC 0.18-μm standard CMOS process. An ARM-based displayer with FPGA demodulation and an RF receiver with analog-to-digital mixed-mode circuits are constructed as verification platform to demonstrate the wireless ECG acquisition system. Measurement results on the human body show that the proposed SoC can effectively acquire ECG signals.

  12. Safety analysis of reactor's cooling system

    International Nuclear Information System (INIS)

    1999-01-01

    Results of the analysis of reactor's RBMK-1500 coolant system during normal operation mode, hydrodynamic testing and in the case of earthquake are presented. Analysis was performed using RELAP5 code. Calculations showed the most vulnerable place in the reactor's coolant system. It was found that in the case of earthquake the horizontal support system of drum separator could be damaged

  13. Systems Analysis and Design: Know Your Audience

    Science.gov (United States)

    Reinicke, Bryan A.

    2012-01-01

    Systems analysis and design (SAD) classes are required in both Information Systems and Accounting programs, but these audiences have very different needs for these skills. This article will review the requirements for SAD within each of these disciplines and compare and contrast the different requirements for teaching systems analysis and design…

  14. Stochastic Reachability Analysis of Hybrid Systems

    CERN Document Server

    Bujorianu, Luminita Manuela

    2012-01-01

    Stochastic reachability analysis (SRA) is a method of analyzing the behavior of control systems which mix discrete and continuous dynamics. For probabilistic discrete systems it has been shown to be a practical verification method but for stochastic hybrid systems it can be rather more. As a verification technique SRA can assess the safety and performance of, for example, autonomous systems, robot and aircraft path planning and multi-agent coordination but it can also be used for the adaptive control of such systems. Stochastic Reachability Analysis of Hybrid Systems is a self-contained and accessible introduction to this novel topic in the analysis and development of stochastic hybrid systems. Beginning with the relevant aspects of Markov models and introducing stochastic hybrid systems, the book then moves on to coverage of reachability analysis for stochastic hybrid systems. Following this build up, the core of the text first formally defines the concept of reachability in the stochastic framework and then...

  15. SOC Strategies and Organizational Citizenship Behaviors toward the Benefits of Co-workers: A Multi-Source Study

    Science.gov (United States)

    Müller, Andreas; Weigl, Matthias

    2017-01-01

    Background: Individuals’ behavioral strategies like selection, optimization, and compensation (SOC) contribute to efficient use of available resources. In the work context, previous studies revealed positive associations between employees’ SOC use and favorable individual outcomes, like engagement and job performance. However, the social implications of self-directed behaviors like SOC that are favorable for the employee but may imply consequences for coworkers have not been investigated yet in an interpersonal work context. Objective: This study aimed to assess associations between employees’ use of SOC behaviors at work and their organizational citizenship behaviors (OCB) toward the benefits of co-workers rated by their peers at work. We further sought to identify age-specific associations between SOC use and OCB. Design and Method: A cross-sectional design combining multi-source data was applied in primary school teachers (age range: 23–58 years) who frequently teach in dyads. N = 114 dyads were finally included. Teachers reported on their SOC strategies at work. Their peer colleagues evaluated teachers’ OCB. Control variables were gender, workload, working hours, and perceived proximity of relationship between the dyads. Results: We observed a positive effect of loss-based selection behaviors on peer-rated OCB. Moreover, there was a significant two-way interaction effect between the use of compensation strategies and age on OCB, such that there was a positive association for older employees and a negative association for younger employees. There were no significant main and age-related interaction effects of elective selection, optimization, and of overall SOC strategies on OCB. Conclusion: Our study suggests that high use of loss-based selection and high use of compensation strategies in older employees is positively related with OCB as perceived by their colleagues. However, high use of compensation strategies in younger employees is perceived

  16. SOC Strategies and Organizational Citizenship Behaviors toward the Benefits of Co-workers: A Multi-Source Study.

    Science.gov (United States)

    Müller, Andreas; Weigl, Matthias

    2017-01-01

    Background: Individuals' behavioral strategies like selection, optimization, and compensation (SOC) contribute to efficient use of available resources. In the work context, previous studies revealed positive associations between employees' SOC use and favorable individual outcomes, like engagement and job performance. However, the social implications of self-directed behaviors like SOC that are favorable for the employee but may imply consequences for coworkers have not been investigated yet in an interpersonal work context. Objective: This study aimed to assess associations between employees' use of SOC behaviors at work and their organizational citizenship behaviors (OCB) toward the benefits of co-workers rated by their peers at work. We further sought to identify age-specific associations between SOC use and OCB. Design and Method: A cross-sectional design combining multi-source data was applied in primary school teachers (age range: 23-58 years) who frequently teach in dyads. N = 114 dyads were finally included. Teachers reported on their SOC strategies at work. Their peer colleagues evaluated teachers' OCB. Control variables were gender, workload, working hours, and perceived proximity of relationship between the dyads. Results: We observed a positive effect of loss-based selection behaviors on peer-rated OCB. Moreover, there was a significant two-way interaction effect between the use of compensation strategies and age on OCB, such that there was a positive association for older employees and a negative association for younger employees. There were no significant main and age-related interaction effects of elective selection, optimization, and of overall SOC strategies on OCB. Conclusion: Our study suggests that high use of loss-based selection and high use of compensation strategies in older employees is positively related with OCB as perceived by their colleagues. However, high use of compensation strategies in younger employees is perceived negatively

  17. ORCHIDEE-SOM: modeling soil organic carbon (SOC) and dissolved organic carbon (DOC) dynamics along vertical soil profiles in Europe

    Science.gov (United States)

    Camino-Serrano, Marta; Guenet, Bertrand; Luyssaert, Sebastiaan; Ciais, Philippe; Bastrikov, Vladislav; De Vos, Bruno; Gielen, Bert; Gleixner, Gerd; Jornet-Puig, Albert; Kaiser, Klaus; Kothawala, Dolly; Lauerwald, Ronny; Peñuelas, Josep; Schrumpf, Marion; Vicca, Sara; Vuichard, Nicolas; Walmsley, David; Janssens, Ivan A.

    2018-03-01

    Current land surface models (LSMs) typically represent soils in a very simplistic way, assuming soil organic carbon (SOC) as a bulk, and thus impeding a correct representation of deep soil carbon dynamics. Moreover, LSMs generally neglect the production and export of dissolved organic carbon (DOC) from soils to rivers, leading to overestimations of the potential carbon sequestration on land. This common oversimplified processing of SOC in LSMs is partly responsible for the large uncertainty in the predictions of the soil carbon response to climate change. In this study, we present a new soil carbon module called ORCHIDEE-SOM, embedded within the land surface model ORCHIDEE, which is able to reproduce the DOC and SOC dynamics in a vertically discretized soil to 2 m. The model includes processes of biological production and consumption of SOC and DOC, DOC adsorption on and desorption from soil minerals, diffusion of SOC and DOC, and DOC transport with water through and out of the soils to rivers. We evaluated ORCHIDEE-SOM against observations of DOC concentrations and SOC stocks from four European sites with different vegetation covers: a coniferous forest, a deciduous forest, a grassland, and a cropland. The model was able to reproduce the SOC stocks along their vertical profiles at the four sites and the DOC concentrations within the range of measurements, with the exception of the DOC concentrations in the upper soil horizon at the coniferous forest. However, the model was not able to fully capture the temporal dynamics of DOC concentrations. Further model improvements should focus on a plant- and depth-dependent parameterization of the new input model parameters, such as the turnover times of DOC and the microbial carbon use efficiency. We suggest that this new soil module, when parameterized for global simulations, will improve the representation of the global carbon cycle in LSMs, thus helping to constrain the predictions of the future SOC response to global

  18. Soil organic matter composition from correlated thermal analysis and nuclear magnetic resonance data in Australian national inventory of agricultural soils

    Science.gov (United States)

    Moore, T. S.; Sanderman, J.; Baldock, J.; Plante, A. F.

    2016-12-01

    National-scale inventories typically include soil organic carbon (SOC) content, but not chemical composition or biogeochemical stability. Australia's Soil Carbon Research Programme (SCaRP) represents a national inventory of SOC content and composition in agricultural systems. The program used physical fractionation followed by 13C nuclear magnetic resonance (NMR) spectroscopy. While these techniques are highly effective, they are typically too expensive and time consuming for use in large-scale SOC monitoring. We seek to understand if analytical thermal analysis is a viable alternative. Coupled differential scanning calorimetry (DSC) and evolved gas analysis (CO2- and H2O-EGA) yields valuable data on SOC composition and stability via ramped combustion. The technique requires little training to use, and does not require fractionation or other sample pre-treatment. We analyzed 300 agricultural samples collected by SCaRP, divided into four fractions: whole soil, coarse particulates (POM), untreated mineral associated (HUM), and hydrofluoric acid (HF)-treated HUM. All samples were analyzed by DSC-EGA, but only the POM and HF-HUM fractions were analyzed by NMR. Multivariate statistical analyses were used to explore natural clustering in SOC composition and stability based on DSC-EGA data. A partial least-squares regression (PLSR) model was used to explore correlations among the NMR and DSC-EGA data. Correlations demonstrated regions of combustion attributable to specific functional groups, which may relate to SOC stability. We are increasingly challenged with developing an efficient technique to assess SOC composition and stability at large spatial and temporal scales. Correlations between NMR and DSC-EGA may demonstrate the viability of using thermal analysis in lieu of more demanding methods in future large-scale surveys, and may provide data that goes beyond chemical composition to better approach quantification of biogeochemical stability.

  19. Fatality Analysis Reporting System ( FARS )

    Data.gov (United States)

    Department of Transportation — The program collects data for analysis of traffic safety crashes to identify problems, and evaluate countermeasures leading to reducing injuries and property damage...

  20. Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C.

    Science.gov (United States)

    Wójcik, Kamila; Jabłonowska, Elżbieta; Omulecka, Aleksandra; Piekarska, Anna

    2014-08-14

    To analyze adipokine concentrations, insulin resistance and hepatic expression of suppressor of cytokine signaling 3 (SOCS-3) in patients with chronic hepatitis C genotype 1 with normal body weight, glucose and lipid profile. The study group consisted of 31 patients with chronic hepatitis C and 9 healthy subjects. Total levels of adiponectin, leptin, resistin, visfatin, omentin, osteopontin and insulin were measured using an ELISA kit. The hepatic expression of SOCS-3 was determined by the use of the reverse transcription polymerase chain reaction method. Homeostasis model assessment for insulin resistance (HOMA-IR) values were significantly higher in hepatitis C virus (HCV) infected patients without metabolic disorders compared to healthy controls (2.24 vs 0.59, P = 0.0003). Hepatic steatosis was observed in 32.2% of patients with HCV infection and was found in patients with increased HOMA-IR index (2.81 vs 1.99, P = 0.05) and reduced adiponectin level (5.96 vs 8.37, P = 0.04). Inflammatory activity (G ≥ 2) was related to increased osteopontin concentration (34.04 vs 23.35, P = 0.03). Advanced liver fibrosis (S ≥ 2) was associated with increased levels of omentin and osteopontin (436.94 vs 360.09, P = 0.03 and 32.84 vs 20.29, P = 0.03) and reduced resistin concentration (1.40 vs 1.74, P = 0.047). No correlations were reported between adipokine profile, HOMA-IR values and hepatic expression of the SOCS-3 gene. We speculated that no relationship between adipokines and HOMA-IR values may indicate that HCV can induce insulin resistance itself. Some adipokines appear to be biochemical markers of steatosis, inflammation and fibrosis in patients with chronic HCV infection. © 2014 Baishideng Publishing Group Inc. All rights reserved.

  1. DMA Controller for LEON3 SoC:s Using AMBA

    OpenAIRE

    Nilsson, Emelie

    2013-01-01

    A DMA Controller can offload a processor tremendously. A memory copy operation can be initiated by the processor and while the processor executes others tasks the memory copy can be fulfilled by the DMA Controller. An implementation of a DMA Controller for use in LEON3 SoC:s has been made during this master thesis. Problems that occurred while designing a controller of this type concerned AMBA buses, data transfers, alignment and interrupt handling. The DMA Controller supports AMBA and is att...

  2. Study of Reversible Logic Synthesis with Application in SOC: A Review

    Science.gov (United States)

    Sharma, Chinmay; Pahuja, Hitesh; Dadhwal, Mandeep; Singh, Balwinder

    2017-08-01

    The prime concern in today’s SOC designs is the power dissipation which increases with technology scaling. The reversible logic possesses very high potential in reducing power dissipation in these designs. It finds its application in latest research fields such as DNA computing, quantum computing, ultra-low power CMOS design and nanotechnology. The reversible circuits can be easily designed using the conventional CMOS technology at a cost of a garbage output which maintains the reversibility. The purpose of this paper is to provide an overview of the developments that have occurred till date in this concept and how the new reversible logic gates are used to design the logic functions.

  3. Risk and safety analysis of nuclear systems

    National Research Council Canada - National Science Library

    Lee, John C; McCormick, Norman J

    2011-01-01

    ...), and failure modes of systems. All of this material is general enough that it could be used in non-nuclear applications, although there is an emphasis placed on the analysis of nuclear systems...

  4. Two sustainable energy system analysis models

    DEFF Research Database (Denmark)

    Lund, Henrik; Goran Krajacic, Neven Duic; da Graca Carvalho, Maria

    2005-01-01

    This paper presents a comparative study of two energy system analysis models both designed with the purpose of analysing electricity systems with a substantial share of fluctuating renewable energy....

  5. Soil Organic Carbon (SOC) distribution in two differents soil types (Podzol and Andosol) under natural forest cover.

    Science.gov (United States)

    Álvarez-Romero, Marta; Papa, Stefania; Verstraeten, Arne; Cools, Nathalie; Lozano-García, Beatriz; Parras-Alcántara, Luis; Coppola, Elio

    2017-04-01

    Andosols are young soils that shall know a successive evolution towards pedological types where the dominant pedogenetic processes are more evident. Vegetation and climate influence Andosols evolution to other order of soils. In cold and wet climates or on acid vulcanite under heavy leaching young Andosols could change into Podzols (Van Breemn and Buurman, 1998). Were investigated a Podzol soil (World References Base, 2014) at Zoniën (Belgium), were and an Andosol soil (World References Base, 2014) at Lago Laceno (Avellino, Italy). This study shows the data on the SOC (Soil Organic Carbon) fractionation in two profiles from two natural pine forest soils. Together with the conventional activities of sampling and analysis of soil profile were examined surveys meant to fractionation and characterization of SOC, in particular: Total Organic Carbon (TOC) and Total Extractable Carbon (TEC) soil contents were determined by Italian official method of soil analysis (Mi.P.A.F. (2000)). Different soil C fractions were also determined: Humic Acid Carbon (HAC), Fulvic Acid Carbon (FAC), Not Humic Carbon (NHC) and Humin Carbon (Huc) fractions were obtained by difference. In the whole profile, therefore, were also assayed cellulose and lignin contents. The aim of this work was to compare the distribution of different soil organic components in a podzol and a soil with andic properties. The data show great similarity, among the selected profiles, in the organic components distribution estudied. References: - Mi.P.A.F. - Ministero per le Politiche Agricole e Forestali - Osservatorio Nazionale Pedologico e per la Qualità del Suolo (2000): Metodi Ufficiali di Analisi Chimica del Suolo. In: Franco Angeli (Editor), Collana di metodi analitici per l'agricoltura diretta da Paolo Sequi, n. 1124.2, Milano, Italy. - Van Breemn N. and Buurman P. (1998) Chapter 12 Formation of Andisols. In: Soil formation. Kluwer Ed., Wageningen, The Netherlands, 271-289. -Ussiri D.A.N., Johnson C

  6. Overview of NASA Langley's Systems Analysis Capabilities

    Science.gov (United States)

    Cavanaugh, Stephen; Kumar, Ajay; Brewer, Laura; Kimmel, Bill; Korte, John; Moul, Tom

    2006-01-01

    The Systems Analysis and Concepts Directorate (SACD) has been in the systems analysis business line supporting National Aeronautics and Space Administration (NASA) aeronautics, exploration, space operations and science since the 1960 s. Our current organization structure is shown in Figure 1. SACD mission can be summed up in the following statements: 1. We conduct advanced concepts for Agency decision makers and programs. 2. We provide aerospace systems analysis products such as mission architectures, advanced system concepts, system and technology trades, life cycle cost and risk analysis, system integration and pre-decisional sensitive information. 3. Our work enables informed technical, programmatic and budgetary decisions. SACD has a complement of 114 government employees and approximately 50 on-site contractors which is equally split between supporting aeronautics and exploration. SACD strives for technical excellence and creditability of the systems analysis products delivered to its customers. The Directorate office is continuously building market intelligence and working with other NASA centers and external partners to expand our business base. The Branches strive for technical excellence and credibility of our systems analysis products by seeking out existing and new partnerships that are critical for successful systems analysis. The Directorates long term goal is to grow the amount of science systems analysis business base.

  7. Importance analysis for reconfigurable systems

    International Nuclear Information System (INIS)

    Si, Shubin; Levitin, Gregory; Dui, Hongyan; Sun, Shudong

    2014-01-01

    Importance measures are used in reliability engineering to rank the system components according to their contributions to proper functioning of the entire system and to find the most effective ways of reliability enhancement. Traditionally, the importance measures do not consider the possible change of system structure with the improvement of specific component reliability. However, if a component's reliability changes, the optimal system structure/configuration may also change and the importance of the corresponding component will depend on the chosen structure. When the most promising component reliability improvement is determined, the component importance should be taken into account with respect to the possible structure changes. This paper studies the component reliability importance indices with respect to the changes of the optimal component sequencing. This importance measure indicates the critical components in providing the system reliability enhancement by both enhancing the component's reliability and reconfiguring the system. Examples of linear consecutive-k-out-of-n: F and G systems are considered to demonstrate the change of the component Birnbaum importance with the optimal system reconfiguration. The results show that the change of the importance index corresponds to the change of the system optimal configuration and the importance index can change not monotonically with the variation of the component reliability

  8. Digraph Matrix Analysis: A new approach to systems interaction analysis

    International Nuclear Information System (INIS)

    Sacks, I.J.; Alesso, H.P.; Ashmore, B.C.

    1985-01-01

    The term Systems Interaction was introduced by the Nuclear Regulatory Commission to identify interdependency of safety and support systems. Digraph Matrix Analysis was developed to allow the determination of these interdependencies. The main features of DMA are: the reliability model is traced directly from system schematics, all components of front line and support systems are included in a single integrated model, and the model is processed automatically with no heuristic culling applied. The recent application of DMA to the Indian Point-3 systems interaction analysis resulted in the discovery of several significant deeply hidden systems interactions

  9. EBT data acquisition and analysis system

    International Nuclear Information System (INIS)

    Burris, R.D.; Greenwood, D.E.; Stanton, J.S.; Geoffroy, K.A.

    1980-10-01

    This document describes the design and implementation of a data acquisition and analysis system for the EBT fusion experiment. The system includes data acquisition on five computers, automatic transmission of that data to a large, central data base, and a powerful data retrieval system. The system is flexible and easy to use, and it provides a fully documented record of the experiments

  10. Systemic Analysis Approaches for Air Transportation

    Science.gov (United States)

    Conway, Sheila

    2005-01-01

    Air transportation system designers have had only limited success using traditional operations research and parametric modeling approaches in their analyses of innovations. They need a systemic methodology for modeling of safety-critical infrastructure that is comprehensive, objective, and sufficiently concrete, yet simple enough to be used with reasonable investment. The methodology must also be amenable to quantitative analysis so issues of system safety and stability can be rigorously addressed. However, air transportation has proven itself an extensive, complex system whose behavior is difficult to describe, no less predict. There is a wide range of system analysis techniques available, but some are more appropriate for certain applications than others. Specifically in the area of complex system analysis, the literature suggests that both agent-based models and network analysis techniques may be useful. This paper discusses the theoretical basis for each approach in these applications, and explores their historic and potential further use for air transportation analysis.

  11. Suppressor of Cytokine Signaling (SOCS 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

    Directory of Open Access Journals (Sweden)

    Edmond M Linossi

    Full Text Available Suppressor of Cytokine Signaling (SOCS5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epidermal growth factor (EGF signaling. However, the mechanism/s by which SOCS5 acts on these two distinct pathways is unclear. We show for the first time that SOCS5 can interact directly with JAK via a unique, conserved region in its N-terminus, which we have termed the JAK interaction region (JIR. Co-expression of SOCS5 was able to specifically reduce JAK1 and JAK2 (but not JAK3 or TYK2 autophosphorylation and this function required both the conserved JIR and additional sequences within the long SOCS5 N-terminal region. We further demonstrate that SOCS5 can directly inhibit JAK1 kinase activity, although its mechanism of action appears distinct from that of SOCS1 and SOCS3. In addition, we identify phosphoTyr317 in Shc-1 as a high-affinity substrate for the SOCS5-SH2 domain and suggest that SOCS5 may negatively regulate EGF and growth factor-driven Shc-1 signaling by binding to this site. These findings suggest that different domains in SOCS5 contribute to two distinct mechanisms for regulation of cytokine and growth factor signaling.

  12. Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.

    Directory of Open Access Journals (Sweden)

    Francesc Vidal

    Full Text Available This was a safety and efficacy pharmacogenetic study of a previously performed randomized trial which compared the effectiveness of treatment of hepatitis C virus infection with pegylated interferon alpha (pegIFNα 2a vs. 2b, both with ribavirin, for 48 weeks, in HCV-HIV coinfected patients.The study groups were made of 99 patients (efficacy pharmacogenetic substudy and of 114 patients (safety pharmacogenetic substudy. Polymorphisms in the following candidate genes IL28B, IL6, IL10, TNFα, IFNγ, CCL5, MxA, OAS1, SOCS3, CTLA4 and ITPA were assessed. Genotyping was carried out using Sequenom iPLEX-Gold, a single-base extension polymerase chain reaction. Efficacy end-points assessed were: rapid, early and sustained virological response (RVR, EVR and SVR, respectively. Safety end-points assessed were: anemia, neutropenia, thrombocytopenia, flu-like syndrome, gastrointestinal disturbances and depression. Chi square test, Student's T test, Mann-Whitney U test and logistic regression were used for statistic analyses.As efficacy is concerned, IL28B and CTLA4 gene polymorphisms were associated with RVR (p<0.05 for both comparisons. Nevertheless, only polymorphism in the IL28B gene was associated with SVR (p = 0.004. In the multivariate analysis, the only gene independently associated with SVR was IL28B (OR 2.61, 95%CI 1.2-5.6, p = 0.01. With respect to safety, there were no significant associations between flu-like syndrome or depression and the genetic variants studied. Gastrointestinal disturbances were associated with ITPA gene polymorphism (p = 0.04. Anemia was associated with OAS1 and CTLA4 gene polymorphisms (p = 0.049 and p = 0.045, respectively, neutropenia and thromobocytopenia were associated with SOCS3 gene polymorphism (p = 0.02 and p = 0.002, respectively. In the multivariate analysis, the associations of the SOCS3 gene polymorphism with neutropenia (OR 0.26, 95%CI 0.09-0.75, p = 0.01 and thrombocytopenia (OR

  13. SASSYS LMFBR systems analysis code

    International Nuclear Information System (INIS)

    Dunn, F.E.; Prohammer, F.G.

    1982-01-01

    The SASSYS code provides detailed steady-state and transient thermal-hydraulic analyses of the reactor core, inlet and outlet coolant plenums, primary and intermediate heat-removal systems, steam generators, and emergency shut-down heat removal systems in liquid-metal-cooled fast-breeder reactors (LMFBRs). The main purpose of the code is to analyze the consequences of failures in the shut-down heat-removal system and to determine whether this system can perform its mission adequately even with some of its components inoperable. The code is not plant-specific. It is intended for use with any LMFBR, using either a loop or a pool design, a once-through steam generator or an evaporator-superheater combination, and either a homogeneous core or a heterogeneous core with internal-blanket assemblies

  14. Observation of self-organized criticality (SOC) behavior during edge biasing experiment on TEXTOR

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Y.H.; Jachmich, S.; Weynants, R.R. [Ecole Royale Militaire/Koninklijke Militaire School, Laboratory for Plasma Physics, Euratom-Belgian State Association, Brussels, Belgium, Partner in the Trilateral Euregio Cluster (Belgium)

    2004-07-01

    The self-organized criticality (SOC) behavior of the edge plasma transport has been investigated using the fluctuation data measured in the plasma edge and the scrape-off layer of TEXTOR tokamak before and during the edge electrode biasing experiments. In the 'non-shear' discharge phase before biasing, both the potential and density fluctuations clearly exhibit some of the characteristics associated with SOC: (1) existence of f{sup -1} power-law dependence in the frequency spectrum, (2) slowly decaying long tails in the autocorrelation function, (3) values of Hurst parameters larger than 0.5 at all the detected radial locations, (4) non-Gaussian probability density function of fluctuations and (5) radial propagation of avalanche-like events in the edge plasma area. During the biasing phase, with the generation of an edge radial electric field E{sub r} and hence a sheared E{sub r} x B flow, the local turbulence is found to be well de-correlated by the E{sub r} x B velocity shear, consistent with theoretical predictions. Nevertheless, it is concomitantly found that the Hurst parameters are substantially enhanced in the negative flow shear region and in the scrape-off layer as well, which is contrary to theoretical expectation. Implication of these observations to our understanding of plasma transport mechanisms is discussed. (authors)

  15. Probabilistic sensitivity analysis of biochemical reaction systems.

    Science.gov (United States)

    Zhang, Hong-Xuan; Dempsey, William P; Goutsias, John

    2009-09-07

    Sensitivity analysis is an indispensable tool for studying the robustness and fragility properties of biochemical reaction systems as well as for designing optimal approaches for selective perturbation and intervention. Deterministic sensitivity analysis techniques, using derivatives of the system response, have been extensively used in the literature. However, these techniques suffer from several drawbacks, which must be carefully considered before using them in problems of systems biology. We develop here a probabilistic approach to sensitivity analysis of biochemical reaction systems. The proposed technique employs a biophysically derived model for parameter fluctuations and, by using a recently suggested variance-based approach to sensitivity analysis [Saltelli et al., Chem. Rev. (Washington, D.C.) 105, 2811 (2005)], it leads to a powerful sensitivity analysis methodology for biochemical reaction systems. The approach presented in this paper addresses many problems associated with derivative-based sensitivity analysis techniques. Most importantly, it produces thermodynamically consistent sensitivity analysis results, can easily accommodate appreciable parameter variations, and allows for systematic investigation of high-order interaction effects. By employing a computational model of the mitogen-activated protein kinase signaling cascade, we demonstrate that our approach is well suited for sensitivity analysis of biochemical reaction systems and can produce a wealth of information about the sensitivity properties of such systems. The price to be paid, however, is a substantial increase in computational complexity over derivative-based techniques, which must be effectively addressed in order to make the proposed approach to sensitivity analysis more practical.

  16. Systems Analysis Department annual progress report 1998

    DEFF Research Database (Denmark)

    1999-01-01

    The report describes the work of the Systems Analysis Department at Risø National Laboratory during 1998. The department undertakes research within Energy Systems Analysis, Integrated Energy, Environment and Development Planning - UNEP Centre, IndustrialSafety and Reliability, Man/Machine Interac....../Machine Interaction, and Technology Scenarios. The report includes lists of publications, lectures, committees and staff members....

  17. Systems Analysis Department annual progress report 1999

    DEFF Research Database (Denmark)

    2000-01-01

    This report describes the work of the Systems Analysis Department at Risø National Laboratory during 1999. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning - UNEP Centre, Safety,Realiability and Human Factors, and Technology...

  18. Analysis and comparison of transportation security systems

    International Nuclear Information System (INIS)

    Rinne, R.L.

    1976-05-01

    The role of modeling in the analysis of transportation security systems is described. Various modeling approaches are outlined. The conflict model developed in Sandia Laboratories' Transportation Mode Analysis for the NRC Special Safeguards Study is used to demonstrate the capability of models to determine system sensitivities and compare alternatives

  19. Verification and Performance Analysis for Embedded Systems

    DEFF Research Database (Denmark)

    Larsen, Kim Guldstrand

    2009-01-01

    This talk provides a thorough tutorial of the UPPAAL tool suite for, modeling, simulation, verification, optimal scheduling, synthesis, testing and performance analysis of embedded and real-time systems.......This talk provides a thorough tutorial of the UPPAAL tool suite for, modeling, simulation, verification, optimal scheduling, synthesis, testing and performance analysis of embedded and real-time systems....

  20. Systems Analysis Department. Annual Report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, H.; Olsson, C. (eds.)

    2004-04-01

    This report describes the work of the Systems Analysis Department at Risoe National Laboratory during 2003. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning UNEP Centre, Safety, Reliability and Human Factors, and Technology Scenarios. The report includes summary statistics and list of staff members. (au)

  1. Systems-Dynamic Analysis for Neighborhood Study

    Science.gov (United States)

    Systems-dynamic analysis (or system dynamics (SD)) helps planners identify interrelated impacts of transportation and land-use policies on neighborhood-scale economic outcomes for households and businesses, among other applications. This form of analysis can show benefits and tr...

  2. Dynamic analysis of nuclear safeguards systems

    International Nuclear Information System (INIS)

    Wilson, J.R.; Rasmuson, D.M.; Tingey, F.H.

    1978-01-01

    The assessment of the safeguards/adversary system poses a unique challenge as evolving technology affects the capabilities of both. The method discussed meets this challenge using a flexible analysis which can be updated by system personnel. The automatically constructed event tree provides a rapid overview analysis for initial assessment, evaluation of changes, cost/benefit study and inspection and audit

  3. Systems Analysis Department. Annual Report 2001

    Energy Technology Data Exchange (ETDEWEB)

    Duijm, N J; Jensen, E; Larsen, H; Skipper, S [eds.

    2002-04-01

    This report describes the work of the Systems Analysis Department at Risoe National Laboratory during 2001. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning - UNEP Centre, Safety, Reliability and Human Factors, and Technology Scenarios. The report includes summary statistics and lists of publications, committees and staff members. (au)

  4. Systems Analysis Department annual report 2003

    DEFF Research Database (Denmark)

    2004-01-01

    This report describes the work of the Systems Analysis Department at Risø National Laboratory during 2003. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning – UNEP Centre, Safety,Reliability and Human Factors, and Technology...... Scenarios. The report includes summary statistics and list of staff members....

  5. Systems Analysis Department. Annual Progress Report 1999

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Hans; Olsson, Charlotte; Loevborg, Leif [eds.

    2000-03-01

    This report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1999. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning-UNEP Centre, Safety, Reliability and Human Factors, and Technology Scenarios. The report includes summary statistics and lists of publications, committees and staff members. (au)

  6. Systems Analysis department. Annual progress report 1997

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Hans; Olsson, Charlotte; Petersen, Kurt E

    1998-03-01

    The report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1997. The department is undertaking research within Energy systems Analysis, Integrated Energy, Environment and Development Planning - UNEP Centre, Industrial Safety and Reliability and Man/Machine Interaction. The report includes lists of publications lectures, committees and staff members. (au) 110 refs.

  7. System Analysis Department. Annual Report 2002

    Energy Technology Data Exchange (ETDEWEB)

    Duijm, N J; Jensen, E; Larsen, H; Skipper, S [eds.

    2002-04-01

    This report describes the work of the Systems Analysis Department at Risoe National Laboratory during 2001. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning - UNEP Centre, Safety, Reliability and Human Factors, and Technology Scenarios. The report includes summary statistics and lists of publications, committees and staff members. (au)

  8. Systems Analysis Department. Annual Report 2000

    Energy Technology Data Exchange (ETDEWEB)

    Duijm, N J; Jensen, E; Larsen, H; Olsson, C

    2001-05-01

    This report describes the work of the Systems Analysis Department at Risoe National Laboratory during 2000. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning - UNEP Centre, Safety, Reliability and Human Factors, and Technology Scenarios. The report includes summary statistics and lists of publications, committees and staff members. (au)

  9. Systems Analysis Department annual progress report 1998

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Hans; Olsson, Charlotte; Loevborg, Leif [eds.

    1999-03-01

    The report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1998. The department undertakes research within Energy Systems Analysis, Integrated Energy, Environment and Development Planning - UNEP Centre, Industrial Safety and Reliability, Man/Machine Interaction and Technology Scenarios. The report includes lists of publications, lectures, committees and staff members. (au) 111 refs.

  10. Reachability Analysis of Probabilistic Systems

    DEFF Research Database (Denmark)

    D'Argenio, P. R.; Jeanett, B.; Jensen, Henrik Ejersbo

    2001-01-01

    than the original model, and may safely refute or accept the required property. Otherwise, the abstraction is refined and the process repeated. As the numerical analysis involved in settling the validity of the property is more costly than the refinement process, the method profits from applying...... such numerical analysis on smaller state spaces. The method is significantly enhanced by a number of novel strategies: a strategy for reducing the size of the numerical problems to be analyzed by identification of so-called {essential states}, and heuristic strategies for guiding the refinement process....

  11. Test-Access Planning and Test Scheduling for Embedded Core-Based System Chips

    NARCIS (Netherlands)

    Goel, Sandeep Kumar

    2005-01-01

    Advances in the semiconductor process technology enable the creation of a complete system on one single die, the so-called system chip or SOC. To reduce time-to-market for large SOCs, reuse of pre-designed and pre-veried blocks called cores is employed. Like the design style, testing of SOCs can be

  12. The Multiplicative Zak Transform, Dimension Reduction, and Wavelet Analysis of LIDAR Data

    Science.gov (United States)

    2010-01-01

    systems is likely to fail. Auslander, Eichmann , Gertner, and Tolimieri defined a multiplicative Zak transform [1], mimicking the construction of the Gabor...L. Auslander, G. Eichmann , I. Gertner and R. Tolimieri, “Time-Frequency Analysis and Synthesis of Non-Stationary Signals,” Proc. Soc. Photo-Opt. In

  13. SOCS3 inhibits the pathological effects of IL-22 in non-melanoma skin tumor-derived keratinocytes.

    Science.gov (United States)

    Madonna, Stefania; Scarponi, Claudia; Morelli, Martina; Sestito, Rosanna; Scognamiglio, Pasqualina Liana; Marasco, Daniela; Albanesi, Cristina

    2017-04-11

    Basal cell carcinomas (BCC) and squamous-cell carcinomas (SCC) are common malignancies in humans, caused by neoplastic transformation of keratinocytes of the basal or suprabasal layers of epidermis, respectively. Tumor-infiltrating lymphocytes (TILs) are frequently found in BCC and SCC, and functionally promote epithelial carcinogenesis. TILs secreting IL-22, in particular, participate to BCC and SCC growth by inducing keratinocyte proliferation and migration, as well as the expression of inflammatory, anti-apoptotic and pro-angiogenic genes.In this study, we identified SOCS3 as a valid candidate to be manipulated for suppressing tumorigenic functions in BCC and SCC. We found that SOCS3 and SOCS1 expression was reduced in vivo, in tumor lesions of BCC and SCC, as compared to other skin inflammatory conditions such as psoriasis, despite the high number of IL-22-secreting TILs. Moreover, IL-22 was not able to induce in vitro the transcriptional expression of SOCS3 in BCC-or SCC-derived keratinocytes, contrarily to healthy cells. Aimed at rescuing SOCS3 activity in these tumor contexts, a SOCS3-derived peptide, named KIR-ESS, was synthesized, and its ability in suppressing IL-22-induced responses was evaluated in healthy and transformed keratinocytes. We found that KIR-ESS peptide efficiently suppressed the IL-22 molecular signaling in keratinocytes, by acting on STAT3 and Erk1/2 cascade, as well as on the expression of STAT3-dependent downstream genes. Interestingly, after treatment with peptide, both healthy and transformed keratinocytes could no longer aberrantly proliferate and migrate in response to IL-22. Finally, treatment of athymic nude mice bearing SCC xenografts with KIR-ESS peptide concomitantly reduced tumor growth and activated STAT3 levels. As a whole, these data provides the rationale for the use in BCC and SCC skin tumors of SOCS3 mimetics, being able to inhibit the deleterious effects of IL-22 in these contexts.

  14. On Bayesian System Reliability Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen Ringi, M

    1995-05-01

    The view taken in this thesis is that reliability, the probability that a system will perform a required function for a stated period of time, depends on a person`s state of knowledge. Reliability changes as this state of knowledge changes, i.e. when new relevant information becomes available. Most existing models for system reliability prediction are developed in a classical framework of probability theory and they overlook some information that is always present. Probability is just an analytical tool to handle uncertainty, based on judgement and subjective opinions. It is argued that the Bayesian approach gives a much more comprehensive understanding of the foundations of probability than the so called frequentistic school. A new model for system reliability prediction is given in two papers. The model encloses the fact that component failures are dependent because of a shared operational environment. The suggested model also naturally permits learning from failure data of similar components in non identical environments. 85 refs.

  15. On Bayesian System Reliability Analysis

    International Nuclear Information System (INIS)

    Soerensen Ringi, M.

    1995-01-01

    The view taken in this thesis is that reliability, the probability that a system will perform a required function for a stated period of time, depends on a person's state of knowledge. Reliability changes as this state of knowledge changes, i.e. when new relevant information becomes available. Most existing models for system reliability prediction are developed in a classical framework of probability theory and they overlook some information that is always present. Probability is just an analytical tool to handle uncertainty, based on judgement and subjective opinions. It is argued that the Bayesian approach gives a much more comprehensive understanding of the foundations of probability than the so called frequentistic school. A new model for system reliability prediction is given in two papers. The model encloses the fact that component failures are dependent because of a shared operational environment. The suggested model also naturally permits learning from failure data of similar components in non identical environments. 85 refs

  16. Fundamentals and applications of systems reliability analysis

    International Nuclear Information System (INIS)

    Boesebeck, K.; Heuser, F.W.; Kotthoff, K.

    1976-01-01

    The lecture gives a survey on the application of methods of reliability analysis to assess the safety of nuclear power plants. Possible statements of reliability analysis in connection with specifications of the atomic licensing procedure are especially dealt with. Existing specifications of safety criteria are additionally discussed with the help of reliability analysis by the example of the reliability analysis of a reactor protection system. Beyond the limited application to single safety systems, the significance of reliability analysis for a closed risk concept is explained in the last part of the lecture. (orig./LH) [de

  17. Power system reliability analysis using fault trees

    International Nuclear Information System (INIS)

    Volkanovski, A.; Cepin, M.; Mavko, B.

    2006-01-01

    The power system reliability analysis method is developed from the aspect of reliable delivery of electrical energy to customers. The method is developed based on the fault tree analysis, which is widely applied in the Probabilistic Safety Assessment (PSA). The method is adapted for the power system reliability analysis. The method is developed in a way that only the basic reliability parameters of the analysed power system are necessary as an input for the calculation of reliability indices of the system. The modeling and analysis was performed on an example power system consisting of eight substations. The results include the level of reliability of current power system configuration, the combinations of component failures resulting in a failed power delivery to loads, and the importance factors for components and subsystems. (author)

  18. Modeling spatial patterns of soil respiration in maize fields from vegetation and soil property factors with the use of remote sensing and geographical information system.

    Directory of Open Access Journals (Sweden)

    Ni Huang

    Full Text Available To examine the method for estimating the spatial patterns of soil respiration (Rs in agricultural ecosystems using remote sensing and geographical information system (GIS, Rs rates were measured at 53 sites during the peak growing season of maize in three counties in North China. Through Pearson's correlation analysis, leaf area index (LAI, canopy chlorophyll content, aboveground biomass, soil organic carbon (SOC content, and soil total nitrogen content were selected as the factors that affected spatial variability in Rs during the peak growing season of maize. The use of a structural equation modeling approach revealed that only LAI and SOC content directly affected Rs. Meanwhile, other factors indirectly affected Rs through LAI and SOC content. When three greenness vegetation indices were extracted from an optical image of an environmental and disaster mitigation satellite in China, enhanced vegetation index (EVI showed the best correlation with LAI and was thus used as a proxy for LAI to estimate Rs at the regional scale. The spatial distribution of SOC content was obtained by extrapolating the SOC content at the plot scale based on the kriging interpolation method in GIS. When data were pooled for 38 plots, a first-order exponential analysis indicated that approximately 73% of the spatial variability in Rs during the peak growing season of maize can be explained by EVI and SOC content. Further test analysis based on independent data from 15 plots showed that the simple exponential model had acceptable accuracy in estimating the spatial patterns of Rs in maize fields on the basis of remotely sensed EVI and GIS-interpolated SOC content, with R2 of 0.69 and root-mean-square error of 0.51 µmol CO2 m(-2 s(-1. The conclusions from this study provide valuable information for estimates of Rs during the peak growing season of maize in three counties in North China.

  19. Modeling Spatial Patterns of Soil Respiration in Maize Fields from Vegetation and Soil Property Factors with the Use of Remote Sensing and Geographical Information System

    Science.gov (United States)

    Huang, Ni; Wang, Li; Guo, Yiqiang; Hao, Pengyu; Niu, Zheng

    2014-01-01

    To examine the method for estimating the spatial patterns of soil respiration (Rs) in agricultural ecosystems using remote sensing and geographical information system (GIS), Rs rates were measured at 53 sites during the peak growing season of maize in three counties in North China. Through Pearson's correlation analysis, leaf area index (LAI), canopy chlorophyll content, aboveground biomass, soil organic carbon (SOC) content, and soil total nitrogen content were selected as the factors that affected spatial variability in Rs during the peak growing season of maize. The use of a structural equation modeling approach revealed that only LAI and SOC content directly affected Rs. Meanwhile, other factors indirectly affected Rs through LAI and SOC content. When three greenness vegetation indices were extracted from an optical image of an environmental and disaster mitigation satellite in China, enhanced vegetation index (EVI) showed the best correlation with LAI and was thus used as a proxy for LAI to estimate Rs at the regional scale. The spatial distribution of SOC content was obtained by extrapolating the SOC content at the plot scale based on the kriging interpolation method in GIS. When data were pooled for 38 plots, a first-order exponential analysis indicated that approximately 73% of the spatial variability in Rs during the peak growing season of maize can be explained by EVI and SOC content. Further test analysis based on independent data from 15 plots showed that the simple exponential model had acceptable accuracy in estimating the spatial patterns of Rs in maize fields on the basis of remotely sensed EVI and GIS-interpolated SOC content, with R2 of 0.69 and root-mean-square error of 0.51 µmol CO2 m−2 s−1. The conclusions from this study provide valuable information for estimates of Rs during the peak growing season of maize in three counties in North China. PMID:25157827

  20. MHD stability analysis of helical system plasmas

    International Nuclear Information System (INIS)

    Nakamura, Yuji

    2000-01-01

    Several topics of the MHD stability studies in helical system plasmas are reviewed with respect to the linear and ideal modes mainly. Difference of the method of the MHD stability analysis in helical system plasmas from that in tokamak plasmas is emphasized. Lack of the cyclic (symmetric) coordinate makes an analysis more difficult. Recent topic about TAE modes in a helical system is also described briefly. (author)

  1. Structured Performance Analysis for Component Based Systems

    OpenAIRE

    Salmi , N.; Moreaux , Patrice; Ioualalen , M.

    2012-01-01

    International audience; The Component Based System (CBS) paradigm is now largely used to design software systems. In addition, performance and behavioural analysis remains a required step for the design and the construction of efficient systems. This is especially the case of CBS, which involve interconnected components running concurrent processes. % This paper proposes a compositional method for modeling and structured performance analysis of CBS. Modeling is based on Stochastic Well-formed...

  2. Analysis And Control System For Automated Welding

    Science.gov (United States)

    Powell, Bradley W.; Burroughs, Ivan A.; Kennedy, Larry Z.; Rodgers, Michael H.; Goode, K. Wayne

    1994-01-01

    Automated variable-polarity plasma arc (VPPA) welding apparatus operates under electronic supervision by welding analysis and control system. System performs all major monitoring and controlling functions. It acquires, analyzes, and displays weld-quality data in real time and adjusts process parameters accordingly. Also records pertinent data for use in post-weld analysis and documentation of quality. System includes optoelectronic sensors and data processors that provide feedback control of welding process.

  3. Seismic analysis of nuclear piping system

    International Nuclear Information System (INIS)

    Shrivastava, S.K.; Pillai, K.R.V.; Nandakumar, S.

    1975-01-01

    To illustrate seismic analysis of nuclear power plant piping, a simple piping system running between two floors of the reactor building is assumed. Reactor building floor response is derived from time-history method. El Centre earthquake (1940) accelerogram is used for time-history analysis. The piping system is analysed as multimass lumped system. Behaviour of the pipe during the said earthquake is discussed. (author)

  4. Transfer function analysis of radiographic imaging systems

    International Nuclear Information System (INIS)

    Metz, C.E.; Doi, K.

    1979-01-01

    The theoretical and experimental aspects of the techniques of transfer function analysis used in radiographic imaging systems are reviewed. The mathematical principles of transfer function analysis are developed for linear, shift-invariant imaging systems, for the relation between object and image and for the image due to a sinusoidal plane wave object. The other basic mathematical principle discussed is 'Fourier analysis' and its application to an input function. Other aspects of transfer function analysis included are alternative expressions for the 'optical transfer function' of imaging systems and expressions are derived for both serial and parallel transfer image sub-systems. The applications of transfer function analysis to radiographic imaging systems are discussed in relation to the linearisation of the radiographic imaging system, the object, the geometrical unsharpness, the screen-film system unsharpness, other unsharpness effects and finally noise analysis. It is concluded that extensive theoretical, computer simulation and experimental studies have demonstrated that the techniques of transfer function analysis provide an accurate and reliable means for predicting and understanding the effects of various radiographic imaging system components in most practical diagnostic medical imaging situations. (U.K.)

  5. Integrated logistic support analysis system

    International Nuclear Information System (INIS)

    Carnicero Iniguez, E.J.; Garcia de la Sen, R.

    1993-01-01

    Integrating logic support into a system results in a large volume of information having to be managed which can only be achieved with the help of computer applications. Both past experience and growing needs in such tasks have led Emperesarios Agrupados to undertake an ambitious development project which is described in this paper. (author)

  6. Analysis of streaming media systems

    NARCIS (Netherlands)

    Lu, Y.

    2010-01-01

    Multimedia services have been popping up at tremendous speed in recent years. A large number of these multimedia streaming systems are introduced to the consumer market. Internet Service Providers, Telecommunications Operators, Service/Content Providers, and end users are interested in the

  7. Impedance analysis of subwoofer systems

    NARCIS (Netherlands)

    Berkhoff, Arthur P.

    The electrical impedance of four low-frequency loudspeaker systems is analyzed. The expression for this impedance is obtained directly from the acoustical analogous circuit. Formulas are derived for calculating the small-signal parameters from the frequencies of impedance minima and maxima of two

  8. Distribution system analysis and automation

    CERN Document Server

    Gers, Juan

    2013-01-01

    A comprehensive guide to techniques that allow engineers to simulate, analyse and optimise power distribution systems which combined with automation, underpin the emerging concept of the "smart grid". This book is supported by theoretical concepts with real-world applications and MATLAB exercises.

  9. The ATLAS distributed analysis system

    OpenAIRE

    Legger, F.

    2014-01-01

    In the LHC operations era, analysis of the multi-petabyte ATLAS data sample by globally distributed physicists is a challenging task. To attain the required scale the ATLAS Computing Model was designed around the concept of grid computing, realized in the Worldwide LHC Computing Grid (WLCG), the largest distributed computational resource existing in the sciences. The ATLAS experiment currently stores over 140 PB of data and runs about 140,000 concurrent jobs continuously at WLCG sites. During...

  10. Content Analysis in Systems Engineering Acquisition Activities

    Science.gov (United States)

    2016-04-30

    Acquisition Activities Karen Holness, Assistant Professor, NPS Update on the Department of the Navy Systems Engineering Career Competency Model Clifford...systems engineering toolkit . Having a common analysis tool that is easy to use would support the feedback of observed system performance trends from the

  11. Analysis of integrated energy systems

    International Nuclear Information System (INIS)

    Matsuhashi, Takaharu; Kaya, Yoichi; Komiyama, Hiroshi; Hayashi, Taketo; Yasukawa, Shigeru.

    1988-01-01

    World attention is now attracted to the concept of Novel Horizontally Integrated Energy System (NHIES). In NHIES, all fossil fuels are fist converted into CO and H 2 . Potential environmental contaminants such as sulfur are removed during this process. CO turbines are mainly used to generate electric power. Combustion is performed in pure oxygen produced through air separation, making it possible to completely prevent the formation of thermal NOx. Thus, NHIES would release very little amount of such substances that would contribute to acid rain. In this system, the intermediate energy sources of CO, H 2 and O 2 are integrated horizontally. They are combined appropriately to produce a specific form of final energy source. The integration of intermediate energy sources can provide a wide variety of final energy sources, allowing any type of fossil fuel to serve as an alternative to other types of fossil fuel. Another feature of NHIES is the positive use of nuclear fuel to reduce the formation of CO 2 . Studies are under way in Japan to develop a new concept of integrated energy system. These studies are especially aimed at decreased overall efficiency and introduction of new liquid fuels that are high in conversion efficiency. Considerations are made on the final form of energy source, robust control, acid fallout, and CO 2 reduction. (Nogami, K.)

  12. Lens system for SIMS analysis

    International Nuclear Information System (INIS)

    Martinez, G.; Sancho, M.; Garcia-Galan, J.C.

    1987-01-01

    A powerful version of the charge-density method is applied to the study of a combined objective and emission lens, suitable for highly localized analysis of a flat sample surface. This lens can extract secondary ions of equal or opposite polarity to that of the primary particles. A computer simulation of the ion trajectories for both modes is made. The behaviour for different values of the geometric parameters and polarizations is analyzed and useful data for design such as primary beam demagnification and secondary image position are given. (author) 4 refs

  13. Improved OCV Model of a Li-Ion NMC Battery for Online SOC Estimation Using the Extended Kalman Filter

    Directory of Open Access Journals (Sweden)

    Ines Baccouche

    2017-05-01

    Full Text Available Accurate modeling of the nonlinear relationship between the open circuit voltage (OCV and the state of charge (SOC is required for adaptive SOC estimation during the lithium-ion (Li-ion battery operation. Online SOC estimation should meet several constraints, such as the computational cost, the number of parameters, as well as the accuracy of the model. In this paper, these challenges are considered by proposing an improved simplified and accurate OCV model of a nickel manganese cobalt (NMC Li-ion battery, based on an empirical analytical characterization approach. In fact, composed of double exponential and simple quadratic functions containing only five parameters, the proposed model accurately follows the experimental curve with a minor fitting error of 1 mV. The model is also valid at a wide temperature range and takes into account the voltage hysteresis of the OCV. Using this model in SOC estimation by the extended Kalman filter (EKF contributes to minimizing the execution time and to reducing the SOC estimation error to only 3% compared to other existing models where the estimation error is about 5%. Experiments are also performed to prove that the proposed OCV model incorporated in the EKF estimator exhibits good reliability and precision under various loading profiles and temperatures.

  14. A project to study SOC evolution after land use change combining chronosequence and gradient methods

    Science.gov (United States)

    Gabarron-Galeote, Miguel A.; van Wesemael, Bas

    2013-04-01

    In the last decades the interest in the global C budget has increased enormously and soils have a great importance in this issue since they contain about twice as much carbon as the atmosphere. Land use change (LUC) can cause a change in land cover and an associated change in carbon stocks in soils, so it has a major impact in the balance between inputs and outputs of soil organic carbon (SOC). Improved understanding of land-use impacts on the world's terrestrial carbon balance is thus a necessary part of the global effort to mitigate climate change. The aim of this project is to predict the effects of land use and land management change on (SOC) stocks, characterizing the soil organic carbon cycle and its relationship to the vegetal cover in croplands abandoned different years ago and under different Mediterranean climatic conditions in South of Spain. The study area is located in the Cordillera Bética Litoral, in South of Spain. In this area, a climatic gradient can be observed from West to East: from >1,500 mm year-1 in the Strait of Gibraltar to <250 mm year-1 in the Cabo de Gata. More specifically, the study is focussed on three different areas from the climatic conditions point of view: Gaucín (1010 mm year-1), Almogía, (576 mm year-1) and Gérgal (240 mm year-1). By means of the analyses of aerial photographs (1956, 1977, 1984, 1998 and 2009) all the experimental plots will be selected. After this procedure, the three study areas will be composed by experimental plots of these classes: a) Lands with natural vegetation since 1956. b) Abandoned lands between 1956 and 1977. c) Abandoned lands between 1977 and 1984. d) Abandoned lands between 1984 and 1998. e) Abandoned lands between 1998 and 2005. f) Cultivated lands since 1956. The main expected outcomes of the research project are the characterization of the temporal evolution of SOC in soils, the compilation of experimental areas under different Mediterranean climatic conditions, and the characterization

  15. Thermodynamic analysis of biochemical systems

    International Nuclear Information System (INIS)

    Yuan, Y.; Fan, L.T.; Shieh, J.H.

    1989-01-01

    Introduction of the concepts of the availability (or exergy), datum level materials, and the dead state has been regarded as some of the most significant recent developments in classical thermodynamics. Not only the available energy balance but also the material and energy balances of a biological system may be established in reference to the datum level materials in the dead state or environment. In this paper these concepts are illustrated with two examples of fermentation and are shown to be useful in identifying sources of thermodynamic inefficiency, thereby leading naturally to the rational definition of thermodynamic efficiency of a biochemical process

  16. A thermodynamic approach for selecting operating conditions in the design of reversible solid oxide cell energy systems

    Science.gov (United States)

    Wendel, Christopher H.; Kazempoor, Pejman; Braun, Robert J.

    2016-01-01

    Reversible solid oxide cell (ReSOC) systems are being increasingly considered for electrical energy storage, although much work remains before they can be realized, including cell materials development and system design optimization. These systems store electricity by generating a synthetic fuel in electrolysis mode and subsequently recover electricity by electrochemically oxidizing the stored fuel in fuel cell mode. System thermal management is improved by promoting methane synthesis internal to the ReSOC stack. Within this strategy, the cell-stack operating conditions are highly impactful on system performance and optimizing these parameters to suit both operating modes is critical to achieving high roundtrip efficiency. Preliminary analysis shows the thermoneutral voltage to be a useful parameter for analyzing ReSOC systems and the focus of this study is to quantitatively examine how it is affected by ReSOC operating conditions. The results reveal that the thermoneutral voltage is generally reduced by increased pressure, and reductions in temperature, fuel utilization, and hydrogen-to-carbon ratio. Based on the thermodynamic analysis, many different combinations of these operating conditions are expected to promote efficient energy storage. Pressurized systems can achieve high efficiency at higher temperature and fuel utilization, while non-pressurized systems may require lower stack temperature and suffer from reduced energy density.

  17. Experimental analysis of disordered systems

    International Nuclear Information System (INIS)

    Nagel, S.R.

    1991-01-01

    Disordered systems present a special challenge to anyone interested in understanding their underlying physical properties. The author sees one aspect of this quite vividly if we compare an amorphous solid with a crystal or periodic system. Suppose you are given a material and are told that it has a particular crystal structure with a specified lattice constant (i.e., nearest-neighbor spacing). Once you are given the position of one atom and the orientation of the crystal, you will know the exact equilibrium position of every atom in the sample. A tremendous amount of information, the position of roughly 1,023 particles, has been conveyed in just a few sentences. It is not surprising that, using mathematical tools, this information can be used efficiently to calculate many of the material's important physical properties. For an amorphous solid, on the other hand, although there may be some short-range order (such as that every atom is surrounded by a well-defined coordination shell of neighbors), there is no long-range order. All that we can say about the material is that at large distances an atom is surrounded by an average density of other particles. A knowledge of this average density is much less impressive than a knowledge of the exact positions of all the particles and it provides much less information with which to construct a theory

  18. Posbist fault tree analysis of coherent systems

    International Nuclear Information System (INIS)

    Huang, H.-Z.; Tong Xin; Zuo, Ming J.

    2004-01-01

    When the failure probability of a system is extremely small or necessary statistical data from the system is scarce, it is very difficult or impossible to evaluate its reliability and safety with conventional fault tree analysis (FTA) techniques. New techniques are needed to predict and diagnose such a system's failures and evaluate its reliability and safety. In this paper, we first provide a concise overview of FTA. Then, based on the posbist reliability theory, event failure behavior is characterized in the context of possibility measures and the structure function of the posbist fault tree of a coherent system is defined. In addition, we define the AND operator and the OR operator based on the minimal cut of a posbist fault tree. Finally, a model of posbist fault tree analysis (posbist FTA) of coherent systems is presented. The use of the model for quantitative analysis is demonstrated with a real-life safety system

  19. The ZYNQ book embedded processing with the ARM Cortex-A9 on the Xilinx Zynq-7000 all programmable SoC

    CERN Document Server

    Crockett, Louise H; Enderwitz, Martin A; Stewart, Robert W

    2014-01-01

    This book is about the Zynq-7000 All Programmable System on Chip, the family of devices from Xilinx that combines an application-grade ARM Cortex-A9 processor with traditional FPGA logic fabric. Catering for both new and experienced readers, it covers fundamental issues in an accessible way, starting with a clear overview of the device architecture, and an introduction to the design tools and processes for developing a Zynq SoC. Later chapters progress to more advanced topics such as embedded systems development, IP block design and operating systems. Maintaining a 'real-world' perspective, the book also compares Zynq with other device alternatives, and considers end-user applications. The Zynq Book is accompanied by a set of practical tutorials hosted on a companion website. These tutorials will guide the reader through first steps with Zynq, following on to a complete, audio-based embedded systems design.

  20. Energy analysis of power systems

    International Nuclear Information System (INIS)

    2004-01-01

    Next to economic viability, the holistic energy balance of electricity generation options' is a factor of major importance. All aspects of the energy balance, i. e. all expenditures and all revenues, are compared in a life cycle analysis. This turns out to be a complex task, especially because of the large number of input quantities to be determined, including the balancing limits to be taken into account. The article presents in detail the findings of analyses of energy balances for various types of nuclear power plants as well as electricity generation in fossil-fired power plants, and for renewable energies. The analyses and their databases are discussed. Moreover, the findings are presented for the energetic amortization periods and the amounts of CO 2 emissions specific to the respective generating technologies. (orig.)

  1. Impact Analysis for Risks in Informatics Systems

    OpenAIRE

    Baicu, Floarea; Baches, Maria Alexandra

    2013-01-01

    In this paper are presented methods of impact analysis on informatics system security accidents, qualitative and quantitative methods, starting with risk and informational system security definitions. It is presented the relationship between the risks of exploiting vulnerabilities of security system, security level of these informatics systems, probability of exploiting the weak points subject to financial losses of a company, respectively impact of a security accident on the company. Herewit...

  2. Analysis of the SIAM Infrared Acquisition System

    Energy Technology Data Exchange (ETDEWEB)

    Varnado, S.G.

    1974-02-01

    This report describes and presents the results of an analysis of the performance of the infrared acquisition system for a Self-Initiated Antiaircraft Missile (SIAM). A description of the optical system is included, and models of target radiant intensity, atmospheric transmission, and background radiance are given. Acquisition probabilities are expressed in terms of the system signal-to-noise ratio. System performance against aircraft and helicopter targets is analyzed, and background discrimination techniques are discussed. 17 refs., 22 figs., 6 tabs.

  3. Automated information retrieval system for radioactivation analysis

    International Nuclear Information System (INIS)

    Lambrev, V.G.; Bochkov, P.E.; Gorokhov, S.A.; Nekrasov, V.V.; Tolstikova, L.I.

    1981-01-01

    An automated information retrieval system for radioactivation analysis has been developed. An ES-1022 computer and a problem-oriented software ''The description information search system'' were used for the purpose. Main aspects and sources of forming the system information fund, characteristics of the information retrieval language of the system are reported and examples of question-answer dialogue are given. Two modes can be used: selective information distribution and retrospective search [ru

  4. EXPOSURE ANALYSIS MODELING SYSTEM (EXAMS): USER MANUAL AND SYSTEM DOCUMENTATION

    Science.gov (United States)

    The Exposure Analysis Modeling System, first published in 1982 (EPA-600/3-82-023), provides interactive computer software for formulating aquatic ecosystem models and rapidly evaluating the fate, transport, and exposure concentrations of synthetic organic chemicals - pesticides, ...

  5. Business Management System Support Analysis

    Science.gov (United States)

    Parikh, Jay

    2008-01-01

    The purpose of this research project was to develop a searchable database compiled with internal and external audit findings/observations. The data will correspond to the findings and observations from the date of Center-wide implementation of the ISO 9001-2000 standard to the present (2003-2008). It was derived and extracted from several sources and was in multiple formats. Once extracted, categorization of the findings/observations would be possible. The final data was mapped to the ISO 9001-2000 standard with the understanding that it will be displayed graphically. The data will be used to verify trends, associate risks, and establish timelines to identify strengths and weaknesses to determine areas of improvement in the Kennedy Space Center Business Management System Internal Audit Program.

  6. Microparticle analysis system and method

    Science.gov (United States)

    Morrison, Dennis R. (Inventor)

    2007-01-01

    A device for analyzing microparticles is provided which includes a chamber with an inlet and an outlet for respectively introducing and dispensing a flowing fluid comprising microparticles, a light source for providing light through the chamber and a photometer for measuring the intensity of light transmitted through individual microparticles. The device further includes an imaging system for acquiring images of the fluid. In some cases, the device may be configured to identify and determine a quantity of the microparticles within the fluid. Consequently, a method for identifying and tracking microparticles in motion is contemplated herein. The method involves flowing a fluid comprising microparticles in laminar motion through a chamber, transmitting light through the fluid, measuring the intensities of the light transmitted through the microparticles, imaging the fluid a plurality of times and comparing at least some of the intensities of light between different images of the fluid.

  7. Energy System Analysis of 100 Per cent Renewable Energy Systems

    DEFF Research Database (Denmark)

    Lund, Henrik; Mathiesen, Brian Vad

    2007-01-01

    This paper presents the methodology and results of the overall energy system analysis of a 100 per cent renewable energy system. The input for the systems is the result of a project of the Danish Association of Engineers, in which 1600 participants during more than 40 seminars discussed...... and designed a model for the future energy system of Denmark, putting emphasis on energy efficiency, CO2 reduction, and industrial development. The energy system analysis methodology includes hour by hour computer simulations leading to the design of flexible energy systems with the ability to balance...... the electricity supply and demand and to exchange electricity productions on the international electricity markets. The results are detailed system designs and energy balances for two energy target years: year 2050 with 100 per cent renewable energy from biomass and combinations of wind, wave and solar power...

  8. Supporting Space Systems Design via Systems Dependency Analysis Methodology

    Science.gov (United States)

    Guariniello, Cesare

    The increasing size and complexity of space systems and space missions pose severe challenges to space systems engineers. When complex systems and Systems-of-Systems are involved, the behavior of the whole entity is not only due to that of the individual systems involved but also to the interactions and dependencies between the systems. Dependencies can be varied and complex, and designers usually do not perform analysis of the impact of dependencies at the level of complex systems, or this analysis involves excessive computational cost, or occurs at a later stage of the design process, after designers have already set detailed requirements, following a bottom-up approach. While classical systems engineering attempts to integrate the perspectives involved across the variety of engineering disciplines and the objectives of multiple stakeholders, there is still a need for more effective tools and methods capable to identify, analyze and quantify properties of the complex system as a whole and to model explicitly the effect of some of the features that characterize complex systems. This research describes the development and usage of Systems Operational Dependency Analysis and Systems Developmental Dependency Analysis, two methods based on parametric models of the behavior of complex systems, one in the operational domain and one in the developmental domain. The parameters of the developed models have intuitive meaning, are usable with subjective and quantitative data alike, and give direct insight into the causes of observed, and possibly emergent, behavior. The approach proposed in this dissertation combines models of one-to-one dependencies among systems and between systems and capabilities, to analyze and evaluate the impact of failures or delays on the outcome of the whole complex system. The analysis accounts for cascading effects, partial operational failures, multiple failures or delays, and partial developmental dependencies. The user of these methods can

  9. Thermal energy systems design and analysis

    CERN Document Server

    Penoncello, Steven G

    2015-01-01

    IntroductionThermal Energy Systems Design and AnalysisSoftwareThermal Energy System TopicsUnits and Unit SystemsThermophysical PropertiesEngineering DesignEngineering EconomicsIntroductionCommon Engineering Economics NomenclatureEconomic Analysis Tool: The Cash Flow DiagramTime Value of MoneyTime Value of Money ExamplesUsing Software to Calculate Interest FactorsEconomic Decision MakingDepreciation and TaxesProblemsAnalysis of Thermal Energy SystemsIntroductionNomenclatureThermophysical Properties of SubstancesSuggested Thermal Energy Systems Analysis ProcedureConserved and Balanced QuantitiesConservation of MassConservation of Energy (The First Law of Thermodynamics)Entropy Balance (The Second Law of Thermodynamics)Exergy Balance: The Combined LawEnergy and Exergy Analysis of Thermal Energy CyclesDetailed Analysis of Thermal Energy CyclesProblemsFluid Transport in Thermal Energy SystemsIntroductionPiping and Tubing StandardsFluid Flow FundamentalsValves and FittingsDesign and Analysis of Pipe NetworksEconomi...

  10. Overview of the land analysis system (LAS)

    Science.gov (United States)

    Quirk, Bruce K.; Olseson, Lyndon R.

    1987-01-01

    The Land Analysis System (LAS) is a fully integrated digital analysis system designed to support remote sensing, image processing, and geographic information systems research. LAS is being developed through a cooperative effort between the National Aeronautics and Space Administration Goddard Space Flight Center and the U. S. Geological Survey Earth Resources Observation Systems (EROS) Data Center. LAS has over 275 analysis modules capable to performing input and output, radiometric correction, geometric registration, signal processing, logical operations, data transformation, classification, spatial analysis, nominal filtering, conversion between raster and vector data types, and display manipulation of image and ancillary data. LAS is currently implant using the Transportable Applications Executive (TAE). While TAE was designed primarily to be transportable, it still provides the necessary components for a standard user interface, terminal handling, input and output services, display management, and intersystem communications. With TAE the analyst uses the same interface to the processing modules regardless of the host computer or operating system. LAS was originally implemented at EROS on a Digital Equipment Corporation computer system under the Virtual Memorial System operating system with DeAnza displays and is presently being converted to run on a Gould Power Node and Sun workstation under the Berkeley System Distribution UNIX operating system.

  11. Soc stock in different forest-related land-uses in central Stara planina mountain, Bulgaria

    Directory of Open Access Journals (Sweden)

    Zhiyanski Miglena

    2009-01-01

    Full Text Available Forest conversions may lead to an accumulation of carbon in vegetation, but little is known about changes in soil C storage with establishment of plantation forests. Understanding these effects is important to addressing issues relevant to ecosystem function and productivity, and to global balance of carbon. The study investigated the effects of the created coniferous plantations on former beech and pasture sites on the soil organic carbon storage. The major forest-related land-uses in the high mountainous regions of central Stara Planina Mountain were investigated: mountainous pasture, coniferous plantations (planted on previous pasture and beech forests between four and five decades ago and natural beech forests. The experimental data of soil properties, conducted in 2005, 2006 and 2007, were used in determining the variations in organic carbon storage in forest litter and in mineral soil under different land-use patterns. At each site five representative soil profiles were opened and described giving a total 75 soil samples from the soil layers respectively at 0-10, 10-30 and 30-50 cm depth. A total of 55 samples from forest floor layers (Aol, Aof, Aoh and greensward were collected with 25:25 cm plastic frame. The main soil properties were determined in accordance with the standardized methods in the Laboratory of soil science at the Forest Research Institute - BAS. The IPCC Good Practice Guidance for Land Use, Land Use Change and Forestry was used to estimate the soil organic carbon stock in soil and litter. The results obtained showed that the SOC stock was quite similar among forest land-uses. The conversion of natural beech forests to coniferous plantations in studied region is related with slightly expressed decrease in soil carbon storage. The values of SOC stocks in 0-50 cm soil layer in these sites were 8.5 (±2.1 tones/ha for pine and 11.0 (±1.4 tones/ha for spruce, while under the natural beech forest it was 14.8 (±1.0 tones

  12. Itinerant ferromagnetism in actinide 5 f -electron systems: Phenomenological analysis with spin fluctuation theory

    Science.gov (United States)

    Tateiwa, Naoyuki; Pospíšil, Jiří; Haga, Yoshinori; Sakai, Hironori; Matsuda, Tatsuma D.; Yamamoto, Etsuji

    2017-07-01

    We have carried out an analysis of magnetic data in 69 uranium, 7 neptunium, and 4 plutonium ferromagnets with the spin fluctuation theory developed by Takahashi [Y. Takahashi, J. Phys. Soc. Jpn. 55, 3553 (1986), 10.1143/JPSJ.55.3553]. The basic and spin fluctuation parameters of the actinide ferromagnets are determined and the applicability of the spin fluctuation theory to actinide 5 f system has been discussed. Itinerant ferromagnets of the 3 d transition metals and their intermetallics follow a generalized Rhodes-Wohlfarth relation between peff/ps and TC/T0 , viz., peff/ps∝(TC/T0) -3 /2 . Here, ps, peff, TC, and T0 are the spontaneous and effective magnetic moments, the Curie temperature, and the width of spin fluctuation spectrum in energy space, respectively. The same relation is satisfied for TC/T0uranium and neptunium ferromagnets below (TC/T0)kink=0.32 ±0.02 , where a kink structure appears in relation between the two quantities. ps increases more weakly above (TC/T0)kink. A possible interpretation with the TC/T0 dependence of ps is given.

  13. Risk and safety analysis of nuclear systems

    National Research Council Canada - National Science Library

    Lee, John C; McCormick, Norman J

    2011-01-01

    .... The first half of the book covers the principles of risk analysis, the techniques used to develop and update a reliability data base, the reliability of multi-component systems, Markov methods used...

  14. QA CLASSIFICATION ANALYSIS OF GROUND SUPPORT SYSTEMS

    International Nuclear Information System (INIS)

    D. W. Gwyn

    1996-01-01

    The purpose and objective of this analysis is to determine if the permanent function Ground Support Systems (CI: BABEEOOOO) are quality-affecting items and if so, to establish the appropriate Quality Assurance (QA) classification

  15. Sandia Laboratories technical capabilities: systems analysis

    International Nuclear Information System (INIS)

    Lundergan, C.D.

    1975-06-01

    The systems analysis capabilities at Sandia Laboratories are summarized. Selected applications of these capabilities are presented to illustrate the extent to which they can be applied in research and development programs. (U.S.)

  16. Formal Modeling and Analysis of Timed Systems

    DEFF Research Database (Denmark)

    Larsen, Kim Guldstrand; Niebert, Peter

    This book constitutes the thoroughly refereed post-proceedings of the First International Workshop on Formal Modeling and Analysis of Timed Systems, FORMATS 2003, held in Marseille, France in September 2003. The 19 revised full papers presented together with an invited paper and the abstracts of ...... systems, discrete time systems, timed languages, and real-time operating systems....... of two invited talks were carefully selected from 36 submissions during two rounds of reviewing and improvement. All current aspects of formal method for modeling and analyzing timed systems are addressed; among the timed systems dealt with are timed automata, timed Petri nets, max-plus algebras, real-time......This book constitutes the thoroughly refereed post-proceedings of the First International Workshop on Formal Modeling and Analysis of Timed Systems, FORMATS 2003, held in Marseille, France in September 2003. The 19 revised full papers presented together with an invited paper and the abstracts...

  17. Rewriting Modulo SMT and Open System Analysis

    Science.gov (United States)

    Rocha, Camilo; Meseguer, Jose; Munoz, Cesar

    2014-01-01

    This paper proposes rewriting modulo SMT, a new technique that combines the power of SMT solving, rewriting modulo theories, and model checking. Rewriting modulo SMT is ideally suited to model and analyze infinite-state open systems, i.e., systems that interact with a non-deterministic environment. Such systems exhibit both internal non-determinism, which is proper to the system, and external non-determinism, which is due to the environment. In a reflective formalism, such as rewriting logic, rewriting modulo SMT can be reduced to standard rewriting. Hence, rewriting modulo SMT naturally extends rewriting-based reachability analysis techniques, which are available for closed systems, to open systems. The proposed technique is illustrated with the formal analysis of: (i) a real-time system that is beyond the scope of timed-automata methods and (ii) automatic detection of reachability violations in a synchronous language developed to support autonomous spacecraft operations.

  18. Integrated tools for control-system analysis

    Science.gov (United States)

    Ostroff, Aaron J.; Proffitt, Melissa S.; Clark, David R.

    1989-01-01

    The basic functions embedded within a user friendly software package (MATRIXx) are used to provide a high level systems approach to the analysis of linear control systems. Various control system analysis configurations are assembled automatically to minimize the amount of work by the user. Interactive decision making is incorporated via menu options and at selected points, such as in the plotting section, by inputting data. There are five evaluations such as the singular value robustness test, singular value loop transfer frequency response, Bode frequency response, steady-state covariance analysis, and closed-loop eigenvalues. Another section describes time response simulations. A time response for random white noise disturbance is available. The configurations and key equations used for each type of analysis, the restrictions that apply, the type of data required, and an example problem are described. One approach for integrating the design and analysis tools is also presented.

  19. Stochastic analysis of biochemical systems

    CERN Document Server

    Anderson, David F

    2015-01-01

    This book focuses on counting processes and continuous-time Markov chains motivated by examples and applications drawn from chemical networks in systems biology.  The book should serve well as a supplement for courses in probability and stochastic processes.  While the material is presented in a manner most suitable for students who have studied stochastic processes up to and including martingales in continuous time, much of the necessary background material is summarized in the Appendix. Students and Researchers with a solid understanding of calculus, differential equations, and elementary probability and who are well-motivated by the applications will find this book of interest.    David F. Anderson is Associate Professor in the Department of Mathematics at the University of Wisconsin and Thomas G. Kurtz is Emeritus Professor in the Departments of Mathematics and Statistics at that university. Their research is focused on probability and stochastic processes with applications in biology and other ar...

  20. Respiratory analysis system and method

    Science.gov (United States)

    Liu, F. F. (Inventor)

    1973-01-01

    A system is described for monitoring the respiratory process in which the gas flow rate and the frequency of respiration and expiration cycles can be determined on a real time basis. A face mask is provided with one-way inlet and outlet valves where the gas flow is through independent flowmeters and through a mass spectrometer. The opening and closing of a valve operates an electrical switch, and the combination of the two switches produces a low frequency electrical signal of the respiratory inhalation and exhalation cycles. During the time a switch is operated, the corresponsing flowmeter produces electric pulses representative of the flow rate; the electrical pulses being at a higher frequency than that of the breathing cycle and combined with the low frequency signal. The high frequency pulses are supplied to conventional analyzer computer which also receives temperature and pressure inputs and computes mass flow rate and totalized mass flow of gas. From the mass spectrometer, components of the gas are separately computed as to flow rate. The electrical switches cause operation of up-down inputs of a reversible counter. The respective up and down cycles can be individually monitored and combined for various respiratory measurements.

  1. SEMICONDUCTOR INTEGRATED CIRCUITS A 10-bit 200-kS/s SAR ADC IP core for a touch screen SoC

    Science.gov (United States)

    Xingyuan, Tong; Yintang, Yang; Zhangming, Zhu; Wenfang, Sheng

    2010-10-01

    Based on a 5 MSBs (most-significant-bits)-plus-5 LSBs (least-significant-bits) C-R hybrid D/A conversion and low-offset pseudo-differential comparison approach, with capacitor array axially symmetric layout topology and resistor string low gradient mismatch placement method, an 8-channel 10-bit 200-kS/s SAR ADC (successive-approximation-register analog-to-digital converter) IP core for a touch screen SoC (system-on-chip) is implemented in a 0.18 μm 1P5M CMOS logic process. Design considerations for the touch screen SAR ADC are included. With a 1.8 V power supply, the DNL (differential non-linearity) and INL (integral non-linearity) of this converter are measured to be about 0.32 LSB and 0.81 LSB respectively. With an input frequency of 91 kHz at 200-kS/s sampling rate, the spurious-free dynamic range and effective-number-of-bits are measured to be 63.2 dB and 9.15 bits respectively, and the power is about 136 μW. This converter occupies an area of about 0.08 mm2. The design results show that it is very suitable for touch screen SoC applications.

  2. Security Implications for Ultra-Low Power Configurable SoC FPAA Embedded Systems

    Directory of Open Access Journals (Sweden)

    Jennifer Hasler

    2018-06-01

    Full Text Available We discuss the impact of physical computing techniques to classifying network security issues for ultra-low power networked IoT devices. Physical computing approaches enable at least a factor of 1000 improvement in computational energy efficiency empowering a new generation of local computational structures for embedded IoT devices. These techniques offer computational capability to address network security concerns. This paper begins the discussion of security opportunities for, and issues using, FPAA devices for small embedded IoT platforms. These FPAAs enable devices often utilized for low-power context aware computation. Embedded FPAA devices have both positive Security attributes, as well as potential vulnerabilities. FPAA devices can be part of the resulting secure computation, such as implementing unique functions. FPAA devices can be used investigate security of analog/mixed signal capabilities. The paper concludes with summarizing key improvements for secure ultra-low power embedded FPAA devices.

  3. An Evaluation Methodology for Protocol Analysis Systems

    Science.gov (United States)

    2007-03-01

    Main Memory Requirement NS: Needham-Schroeder NSL: Needham-Schroeder-Lowe OCaml : Objective Caml POSIX: Portable Operating System...methodology is needed. A. PROTOCOL ANALYSIS FIELD As with any field, there is a specialized language used within the protocol analysis community. Figure...ProVerif requires that Objective Caml ( OCaml ) be installed on the system, OCaml version 3.09.3 was installed. C. WINDOWS CONFIGURATION OS

  4. The Changeable Block Distance System Analysis

    Science.gov (United States)

    Lewiński, Andrzej; Toruń, Andrzej

    The paper treats about efficiency analysis in Changeable Block Distance (CBD) System connected with wireless positioning and control of train. The analysis is based on modeling of typical ERTMS line and comparison with actual and future traffic. The calculations are related to assumed parameters of railway traffic corresponding to real time - table of distance Psary - Góra Włodowska from CMK line equipped in classic, ETCS Level 1 and ETCS with CBD systems.

  5. Systems Engineering Analysis for Office Space Management

    Science.gov (United States)

    2017-09-01

    ENGINEERING ANALYSIS FOR OFFICE SPACE MANAGEMENT by James E. Abellana September 2017 Thesis Advisor: Diana Angelis Second Reader: Walter E. Owen...Master’s thesis 4. TITLE AND SUBTITLE SYSTEMS ENGINEERING ANALYSIS FOR OFFICE SPACE MANAGEMENT 5. FUNDING NUMBERS 6. AUTHOR(S) James E. Abellana 7...of the systems engineering method, this thesis develops a multicriteria decision-making framework applicable to space allocation decisions for

  6. Multi-Disciplinary System Reliability Analysis

    Science.gov (United States)

    Mahadevan, Sankaran; Han, Song

    1997-01-01

    The objective of this study is to develop a new methodology for estimating the reliability of engineering systems that encompass multiple disciplines. The methodology is formulated in the context of the NESSUS probabilistic structural analysis code developed under the leadership of NASA Lewis Research Center. The NESSUS code has been successfully applied to the reliability estimation of a variety of structural engineering systems. This study examines whether the features of NESSUS could be used to investigate the reliability of systems in other disciplines such as heat transfer, fluid mechanics, electrical circuits etc., without considerable programming effort specific to each discipline. In this study, the mechanical equivalence between system behavior models in different disciplines are investigated to achieve this objective. A new methodology is presented for the analysis of heat transfer, fluid flow, and electrical circuit problems using the structural analysis routines within NESSUS, by utilizing the equivalence between the computational quantities in different disciplines. This technique is integrated with the fast probability integration and system reliability techniques within the NESSUS code, to successfully compute the system reliability of multi-disciplinary systems. Traditional as well as progressive failure analysis methods for system reliability estimation are demonstrated, through a numerical example of a heat exchanger system involving failure modes in structural, heat transfer and fluid flow disciplines.

  7. Suppressor of cytokine signaling 2 (Socs2 deletion protects bone health of mice with DSS-induced inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    Ross Dobie

    2018-01-01

    Full Text Available Individuals with inflammatory bowel disease (IBD often present with poor bone health. The development of targeted therapies for this bone loss requires a fuller understanding of the underlying cellular mechanisms. Although bone loss in IBD is multifactorial, the altered sensitivity and secretion of growth hormone (GH and insulin-like growth factor-1 (IGF-1 in IBD is understood to be a critical contributing mechanism. The expression of suppressor of cytokine signaling 2 (SOCS2, a well-established negative regulator of GH signaling, is stimulated by proinflammatory cytokines. Therefore, it is likely that SOCS2 expression represents a critical mediator through which proinflammatory cytokines inhibit GH/IGF-1 signaling and decrease bone quality in IBD. Using the dextran sodium sulfate (DSS model of colitis, we reveal that endogenously elevated GH function in the Socs2−/− mouse protects the skeleton from osteopenia. Micro-computed tomography assessment of DSS-treated wild-type (WT mice revealed a worsened trabecular architecture compared to control mice. Specifically, DSS-treated WT mice had significantly decreased bone volume, trabecular thickness and trabecular number, and a resulting increase in trabecular separation. In comparison, the trabecular bone of Socs2-deficient mice was partially protected from the adverse effects of DSS. The reduction in a number of parameters, including bone volume, was less, and no changes were observed in trabecular thickness or separation. This protected phenotype was unlikely to be a consequence of improved mucosal health in the DSS-treated Socs2−/− mice but rather a result of unregulated GH signaling directly on bone. These studies indicate that the absence of SOCS2 is protective against bone loss typical of IBD. This study also provides an improved understanding of the relative effects of GH/IGF-1 signaling on bone health in experimental colitis, information that is essential before these drugs are

  8. [Characteristics of Soil Respiration along Eroded Sloping Land with Different SOC Background on the Hilly Loess Plateau].

    Science.gov (United States)

    Chen, Gai; Xu, Ming-xiang; Zhang, Ya-feng; Wang, Chao-hua; Fan, Hui-min; Wang, Shan-shan

    2015-09-01

    This study aimed to characterize soil respiration along eroded sloping land at erosion and deposition area under different soil organic carbon(SOC) levels, and linked the relationship between soil respiration and soil temperature, soil moisture, SOC and slope position. Experiments were carried out in the plots of S type slopes include five different soil organic carbon levels in the Loess Hilly Region. The S type slopes were divided into control area at the top of the slope, erosion area at the middle of the slope and deposition area at the toe of the slope. We found that soil temperature had a greater impact on soil respiration in the deposition area, whereas soil moisture had a greater impact on soil respiration in the erosion area compared among control area, erosion area and deposition area. In addition, SOC was the most important factor affecting soil respiration, which can explain soil respiration variation 54. 72%, followed by soil moisture, slope position and soil temperature, which explain soil respiration variation 18. 86% , 16. 13% and 10. 29%, respectively. Soil respiration response to erosion showed obvious on-site and off-site effects along the eroded sloping land. Soil respiration in the erosion area was reduced by 21. 14% compared with control area, and soil respiration in the deposition area was increased by 21. 93% compared with control area. Erosion effect on source and sink of carbon emission was correlated with SOC content of the eroded sloping land. When SOC content was higher than 6. 82 g.kg-1, the slope. erosion tended to be a carbon sequestration process, and when SOC content was lower than 3.03 g.kg-1, the slope erosion tended to be a process of the carbon emission source. The model could reflect the relationship between soil respiration and independent variables of soil organic carbon content, soil temperature and moisture.

  9. Mechatronic Systems Analysis, Design and Implementation

    CERN Document Server

    Boukas, El-Kébir

    2012-01-01

    This book deals with the analysis, the design and the implementation of the mechatronic systems. Classical and modern tools are developed for the analysis and the design for such systems. Robust control, H-Infinity and guaranteed cost control theory are also used for analysis and design of mechatronic systems. Different controller such as state feedback, static output feedback and dynamic output feedback controllers are used to stabilize mechatronic systems. Heuristic algorithms are provided to solve the design of the classical controller such as PID, phase lead, phase lag and phase lead-lag controllers while linear matrix inequalities (LMI) algorithms are provided for finding solutions to the state feedback, static output feedback and dynamic output feedback controllers. The theory presented in the different chapters of the volume is applied to numerical examples to show the usefulness of the theoretical results. Some case studies are also provided to show how the developed concepts apply for real system. Em...

  10. Failure analysis of real-time systems

    International Nuclear Information System (INIS)

    Jalashgar, A.; Stoelen, K.

    1998-01-01

    This paper highlights essential aspects of real-time software systems that are strongly related to the failures and their course of propagation. The significant influence of means-oriented and goal-oriented system views in the description, understanding and analysing of those aspects is elaborated. The importance of performing failure analysis prior to reliability analysis of real-time systems is equally addressed. Problems of software reliability growth models taking the properties of such systems into account are discussed. Finally, the paper presents a preliminary study of a goal-oriented approach to model the static and dynamic characteristics of real-time systems, so that the corresponding analysis can be based on a more descriptive and informative picture of failures, their effects and the possibility of their occurrence. (author)

  11. Systems Analysis | Hydrogen and Fuel Cells | NREL

    Science.gov (United States)

    chain costs, sustainability metrics, and financial analyses within an optimization framework. NREL's , Handbook of Clean Energy Systems (2015) Retail Infrastructure Costs Comparison for Hydrogen and Electricity Heimiller, and Jenny Melius (2012) Infrastructure Analysis Tools: A Focus on Cash Flow Analysis, Hydrogen

  12. Automated Analysis of Security in Networking Systems

    DEFF Research Database (Denmark)

    Buchholtz, Mikael

    2004-01-01

    such networking systems are modelled in the process calculus LySa. On top of this programming language based formalism an analysis is developed, which relies on techniques from data and control ow analysis. These are techniques that can be fully automated, which make them an ideal basis for tools targeted at non...

  13. Fuel Cycle System Analysis Handbook

    International Nuclear Information System (INIS)

    Piet, Steven J.; Dixon, Brent W.; Gombert, Dirk; Hoffman, Edward A.; Matthern, Gretchen E.; Williams, Kent A.

    2009-01-01

    This Handbook aims to improve understanding and communication regarding nuclear fuel cycle options. It is intended to assist DOE, Campaign Managers, and other presenters prepare presentations and reports. When looking for information, check here. The Handbook generally includes few details of how calculations were performed, which can be found by consulting references provided to the reader. The Handbook emphasizes results in the form of graphics and diagrams, with only enough text to explain the graphic, to ensure that the messages associated with the graphic is clear, and to explain key assumptions and methods that cause the graphed results. Some of the material is new and is not found in previous reports, for example: (1) Section 3 has system-level mass flow diagrams for 0-tier (once-through), 1-tier (UOX to CR=0.50 fast reactor), and 2-tier (UOX to MOX-Pu to CR=0.50 fast reactor) scenarios - at both static and dynamic equilibrium. (2) To help inform fast reactor transuranic (TRU) conversion ratio and uranium supply behavior, section 5 provides the sustainable fast reactor growth rate as a function of TRU conversion ratio. (3) To help clarify the difference in recycling Pu, NpPu, NpPuAm, and all-TRU, section 5 provides mass fraction, gamma, and neutron emission for those four cases for MOX, heterogeneous LWR IMF (assemblies mixing IMF and UOX pins), and a CR=0.50 fast reactor. There are data for the first 10 LWR recycle passes and equilibrium. (4) Section 6 provides information on the cycle length, planned and unplanned outages, and TRU enrichment as a function of fast reactor TRU conversion ratio, as well as the dilution of TRU feedstock by uranium in making fast reactor fuel. (The recovered uranium is considered to be more pure than recovered TRU.) The latter parameter impacts the required TRU impurity limits specified by the Fuels Campaign. (5) Section 7 provides flows for an 800-tonne UOX separation plant. (6) To complement 'tornado' economic uncertainty

  14. Dynamic Voltage-Frequency and Workload Joint Scaling Power Management for Energy Harvesting Multi-Core WSN Node SoC

    Directory of Open Access Journals (Sweden)

    Xiangyu Li

    2017-02-01

    Full Text Available This paper proposes a scheduling and power management solution for energy harvesting heterogeneous multi-core WSN node SoC such that the system continues to operate perennially and uses the harvested energy efficiently. The solution consists of a heterogeneous multi-core system oriented task scheduling algorithm and a low-complexity dynamic workload scaling and configuration optimization algorithm suitable for light-weight platforms. Moreover, considering the power consumption of most WSN applications have the characteristic of data dependent behavior, we introduce branches handling mechanism into the solution as well. The experimental result shows that the proposed algorithm can operate in real-time on a lightweight embedded processor (MSP430, and that it can make a system do more valuable works and make more than 99.9% use of the power budget.

  15. SOC Strategies and Organizational Citizenship Behaviors toward the Benefits of Co-workers: A Multi-Source Study

    Directory of Open Access Journals (Sweden)

    Andreas Müller

    2017-10-01

    Full Text Available Background: Individuals’ behavioral strategies like selection, optimization, and compensation (SOC contribute to efficient use of available resources. In the work context, previous studies revealed positive associations between employees’ SOC use and favorable individual outcomes, like engagement and job performance. However, the social implications of self-directed behaviors like SOC that are favorable for the employee but may imply consequences for coworkers have not been investigated yet in an interpersonal work context.Objective: This study aimed to assess associations between employees’ use of SOC behaviors at work and their organizational citizenship behaviors (OCB toward the benefits of co-workers rated by their peers at work. We further sought to identify age-specific associations between SOC use and OCB.Design and Method: A cross-sectional design combining multi-source data was applied in primary school teachers (age range: 23–58 years who frequently teach in dyads. N = 114 dyads were finally included. Teachers reported on their SOC strategies at work. Their peer colleagues evaluated teachers’ OCB. Control variables were gender, workload, working hours, and perceived proximity of relationship between the dyads.Results: We observed a positive effect of loss-based selection behaviors on peer-rated OCB. Moreover, there was a significant two-way interaction effect between the use of compensation strategies and age on OCB, such that there was a positive association for older employees and a negative association for younger employees. There were no significant main and age-related interaction effects of elective selection, optimization, and of overall SOC strategies on OCB.Conclusion: Our study suggests that high use of loss-based selection and high use of compensation strategies in older employees is positively related with OCB as perceived by their colleagues. However, high use of compensation strategies in younger employees is

  16. Benefit analysis of proposed information systems

    OpenAIRE

    Besore, Mark H.

    1991-01-01

    Approved for public release; distribution is unlimited This thesis reviewed two different approaches to benefit analysis, benefit comparison and user satisfaction, that could be applied to the evaluation of proposed information systems which are under consideration for acquisition by the federal government. Currently the General Services Administration only recommends that present value analysis methods be used in the analysis of alternatives even though the GSA specifies...

  17. Municipal solid waste management system: decision support through systems analysis

    OpenAIRE

    Pires, Ana Lúcia Lourenço

    2010-01-01

    Thesis submitted to the Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia for the degree of Doctor of Philosophy in Environmental Engineering The present study intends to show the development of systems analysis model applied to solid waste management system, applied into AMARSUL, a solid waste management system responsible for the management of municipal solid waste produced in Setúbal peninsula, Portugal. The model developed intended to promote sustainable decision making, ...

  18. A Real-Time evaluation system for a state-of-charge indication algorithm

    NARCIS (Netherlands)

    Pop, V.; Bergveld, H.J.; Notten, P.H.L.; Regtien, Paulus P.L.

    2005-01-01

    The known methods of State-of-Charge (SoC) indication in portable applications are not accurate enough under all practical conditions. This paper describes a real- time evaluation LabVIEW system for an SoC algorithm, that calculates the SoC in [%] and also the remaining run-time available under the

  19. A real-time evaluation system for a state-of-charge indication algorithm

    NARCIS (Netherlands)

    Pop, V.; Bergveld, H.J.; Notten, P.H.L.; Regtien, P.P.L.

    2005-01-01

    The known methods of State-of-Charge (SoC) indication in portable applications are not accurate enough under all practical conditions. This paper describes a real- time evaluation LabVIEW system for an SoC algorithm, that calculates the SoC in [%] and also the remaining run-time available under the

  20. Reliability analysis in interdependent smart grid systems

    Science.gov (United States)

    Peng, Hao; Kan, Zhe; Zhao, Dandan; Han, Jianmin; Lu, Jianfeng; Hu, Zhaolong

    2018-06-01

    Complex network theory is a useful way to study many real complex systems. In this paper, a reliability analysis model based on complex network theory is introduced in interdependent smart grid systems. In this paper, we focus on understanding the structure of smart grid systems and studying the underlying network model, their interactions, and relationships and how cascading failures occur in the interdependent smart grid systems. We propose a practical model for interdependent smart grid systems using complex theory. Besides, based on percolation theory, we also study the effect of cascading failures effect and reveal detailed mathematical analysis of failure propagation in such systems. We analyze the reliability of our proposed model caused by random attacks or failures by calculating the size of giant functioning components in interdependent smart grid systems. Our simulation results also show that there exists a threshold for the proportion of faulty nodes, beyond which the smart grid systems collapse. Also we determine the critical values for different system parameters. In this way, the reliability analysis model based on complex network theory can be effectively utilized for anti-attack and protection purposes in interdependent smart grid systems.

  1. Dynamic Systems Analysis for Turbine Based Aero Propulsion Systems

    Science.gov (United States)

    Csank, Jeffrey T.

    2016-01-01

    The aircraft engine design process seeks to optimize the overall system-level performance, weight, and cost for a given concept. Steady-state simulations and data are used to identify trade-offs that should be balanced to optimize the system in a process known as systems analysis. These systems analysis simulations and data may not adequately capture the true performance trade-offs that exist during transient operation. Dynamic systems analysis provides the capability for assessing the dynamic tradeoffs at an earlier stage of the engine design process. The dynamic systems analysis concept, developed tools, and potential benefit are presented in this paper. To provide this capability, the Tool for Turbine Engine Closed-loop Transient Analysis (TTECTrA) was developed to provide the user with an estimate of the closed-loop performance (response time) and operability (high pressure compressor surge margin) for a given engine design and set of control design requirements. TTECTrA along with engine deterioration information, can be used to develop a more generic relationship between performance and operability that can impact the engine design constraints and potentially lead to a more efficient engine.

  2. Source-system windowing for speech analysis

    NARCIS (Netherlands)

    Yegnanarayana, B.; Satyanarayana Murthy, P.; Eggen, J.H.

    1993-01-01

    In this paper we propose a speech-analysis method to bring out characteristics of the vocal tract system in short segments which are much less than a pitch period. The method performs windowing in the source and system components of the speech signal and recombines them to obtain a signal reflecting

  3. An anomaly analysis framework for database systems

    NARCIS (Netherlands)

    Vavilis, S.; Egner, A.I.; Petkovic, M.; Zannone, N.

    2015-01-01

    Anomaly detection systems are usually employed to monitor database activities in order to detect security incidents. These systems raise an alert when anomalous activities are detected. The raised alerts have to be analyzed to timely respond to the security incidents. Their analysis, however, is

  4. Chip based electroanalytical systems for cell analysis

    DEFF Research Database (Denmark)

    Spegel, C.; Heiskanen, A.; Skjolding, L.H.D.

    2008-01-01

    ' measurements of processes related to living cells, i.e., systems without lysing the cells. The focus is on chip based amperometric and impedimetric cell analysis systems where measurements utilizing solely carbon fiber microelectrodes (CFME) and other nonchip electrode formats, such as CFME for exocytosis...

  5. Safety analysis of accident localization system

    International Nuclear Information System (INIS)

    1999-01-01

    A complex safety analysis of accident localization system of Ignalina NPP was performed. Calculation results obtained, results of non-destruct ing testing and experimental data of reinforced concrete testing of buildings does not revealed deficiencies of buildings of accident localization system at unit 1 of Ignalina NPP. Calculations were performed using codes NEPTUNE, ALGOR, CONTAIN

  6. Scientific & Intelligence Exascale Visualization Analysis System

    Energy Technology Data Exchange (ETDEWEB)

    2017-07-14

    SIEVAS provides an immersive visualization framework for connecting multiple systems in real time for data science. SIEVAS provides the ability to connect multiple COTS and GOTS products in a seamless fashion for data fusion, data analysis, and viewing. It provides this capability by using a combination of micro services, real time messaging, and web service compliant back-end system.

  7. Systems Analysis Department. Annual progress report 1996

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, H; Olsson, C; Petersen, K E [eds.

    1997-03-01

    The report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1996. The department is undertaking research within Simulation and Optimisation of Energy Systems, Energy and Environment in Developing Countries - UNEP Centre, Integrated Environmental and Risk Management and Man/Machine Interaction. The report includes lists of publications, lectures, committees and staff members. (au) 131 refs.

  8. Real-time systems design and analysis

    CERN Document Server

    Laplante, Phillip A

    2004-01-01

    "Real-Time Systems Design and Analysis, Third Edition is essential for students and practicing software engineers who want improved designs, faster computation, and ultimate cost savings. Chapters discuss hardware considerations and software requirements, software systems design, the software production process, performance estimation and optimization, and engineering considerations."--Jacket.

  9. Affordances of agricultural systems analysis tools

    NARCIS (Netherlands)

    Ditzler, Lenora; Klerkx, Laurens; Chan-Dentoni, Jacqueline; Posthumus, Helena; Krupnik, Timothy J.; Ridaura, Santiago López; Andersson, Jens A.; Baudron, Frédéric; Groot, Jeroen C.J.

    2018-01-01

    The increasingly complex challenges facing agricultural systems require problem-solving processes and systems analysis (SA) tools that engage multiple actors across disciplines. In this article, we employ the theory of affordances to unravel what tools may furnish users, and how those affordances

  10. Vehicle Systems Analysis Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    The mission of the Vehicle Systems Analysis Technical Team (VSATT) is to evaluate the performance and interactions of proposed advanced automotive powertrain components and subsystems, in a vehicle systems context, to inform ongoing research and development activities and maximize the potential for fuel efficiency improvements and emission reduction.

  11. Sail GTS ground system analysis: Avionics system engineering

    Science.gov (United States)

    Lawton, R. M.

    1977-01-01

    A comparison of two different concepts for the guidance, navigation and control test set signal ground system is presented. The first is a concept utilizing a ground plate to which crew station, avionics racks, electrical power distribution system, master electrical common connection assembly and marshall mated elements system grounds are connected by 4/0 welding cable. An alternate approach has an aluminum sheet interconnecting the signal ground reference points between the crew station and avionics racks. The comparison analysis quantifies the differences between the two concepts in terms of dc resistance, ac resistance and inductive reactance. These parameters are figures of merit for ground system conductors in that the system with the lowest impedance is the most effective in minimizing noise voltage. Although the welding cable system is probably adequate, the aluminum sheet system provides a higher probability of a successful system design.

  12. Operationalizing sustainability in urban coastal systems: a system dynamics analysis.

    Science.gov (United States)

    Mavrommati, Georgia; Bithas, Kostas; Panayiotidis, Panayiotis

    2013-12-15

    We propose a system dynamics approach for Ecologically Sustainable Development (ESD) in urban coastal systems. A systematic analysis based on theoretical considerations, policy analysis and experts' knowledge is followed in order to define the concept of ESD. The principles underlying ESD feed the development of a System Dynamics Model (SDM) that connects the pollutant loads produced by urban systems' socioeconomic activities with the ecological condition of the coastal ecosystem that it is delineated in operational terms through key biological elements defined by the EU Water Framework Directive. The receiving waters of the Athens Metropolitan area, which bears the elements of typical high population density Mediterranean coastal city but which currently has also new dynamics induced by the ongoing financial crisis, are used as an experimental system for testing a system dynamics approach to apply the concept of ESD. Systems' thinking is employed to represent the complex relationships among the components of the system. Interconnections and dependencies that determine the potentials for achieving ESD are revealed. The proposed system dynamics analysis can facilitate decision makers to define paths of development that comply with the principles of ESD. Copyright © 2013 Elsevier Ltd. All rights reserved.

  13. Signals and transforms in linear systems analysis

    CERN Document Server

    Wasylkiwskyj, Wasyl

    2013-01-01

    Signals and Transforms in Linear Systems Analysis covers the subject of signals and transforms, particularly in the context of linear systems theory. Chapter 2 provides the theoretical background for the remainder of the text. Chapter 3 treats Fourier series and integrals. Particular attention is paid to convergence properties at step discontinuities. This includes the Gibbs phenomenon and its amelioration via the Fejer summation techniques. Special topics include modulation and analytic signal representation, Fourier transforms and analytic function theory, time-frequency analysis and frequency dispersion. Fundamentals of linear system theory for LTI analogue systems, with a brief account of time-varying systems, are covered in Chapter 4 . Discrete systems are covered in Chapters 6 and 7.  The Laplace transform treatment in Chapter 5 relies heavily on analytic function theory as does Chapter 8 on Z -transforms. The necessary background on complex variables is provided in Appendix A. This book is intended to...

  14. Computer-aided power systems analysis

    CERN Document Server

    Kusic, George

    2008-01-01

    Computer applications yield more insight into system behavior than is possible by using hand calculations on system elements. Computer-Aided Power Systems Analysis: Second Edition is a state-of-the-art presentation of basic principles and software for power systems in steady-state operation. Originally published in 1985, this revised edition explores power systems from the point of view of the central control facility. It covers the elements of transmission networks, bus reference frame, network fault and contingency calculations, power flow on transmission networks, generator base power setti

  15. Inelastic analysis methods for piping systems

    International Nuclear Information System (INIS)

    Boyle, J.T.; Spence, J.

    1980-01-01

    The analysis of pipework systems which operate in an environment where local inelastic strains are evident is one of the most demanding problems facing the stress analyst in the nuclear field. The spatial complexity of even the most modest system makes a detailed analysis using finite element techniques beyond the scope of current computer technology. For this reason the emphasis has been on simplified methods. It is the aim of this paper to provide a reasonably complete, state-of-the-art review of inelastic pipework analysis methods and to attempt to highlight areas where reliable information is lacking and further work is needed. (orig.)

  16. Risk Analysis of Accounting Information System Infrastructure

    OpenAIRE

    MIHALACHE, Arsenie-Samoil

    2011-01-01

    National economy and security are fully dependent on information technology and infrastructure. At the core of the information infrastructure society relies on, we have the Internet, a system designed initially as a scientists’ forum for unclassified research. The use of communication networks and systems may lead to hazardous situations that generate undesirable effects such as communication systems breakdown, loss of data or taking the wrong decisions. The paper studies the risk analysis of...

  17. Waste Feed Delivery Transfer System Analysis

    Energy Technology Data Exchange (ETDEWEB)

    JULYK, L.J.

    2000-05-05

    This document provides a documented basis for the required design pressure rating and pump pressure capacity of the Hanford Site waste-transfer system in support of the waste feed delivery to the privatization contractor for vitrification. The scope of the analysis includes the 200 East Area double-shell tank waste transfer pipeline system and the associated transfer system pumps for a11 Phase 1B and Phase 2 waste transfers from AN, AP, AW, AY, and A2 Tank Farms.

  18. Waste Feed Delivery Transfer System Analysis

    International Nuclear Information System (INIS)

    JULYK, L.J.

    2000-01-01

    This document provides a documented basis for the required design pressure rating and pump pressure capacity of the Hanford Site waste-transfer system in support of the waste feed delivery to the privatization contractor for vitrification. The scope of the analysis includes the 200 East Area double-shell tank waste transfer pipeline system and the associated transfer system pumps for a11 Phase 1B and Phase 2 waste transfers from AN, AP, AW, AY, and A2 Tank Farms

  19. Reliability analysis of Angra I safety systems

    International Nuclear Information System (INIS)

    Oliveira, L.F.S. de; Soto, J.B.; Maciel, C.C.; Gibelli, S.M.O.; Fleming, P.V.; Arrieta, L.A.

    1980-07-01

    An extensive reliability analysis of some safety systems of Angra I, are presented. The fault tree technique, which has been successfully used in most reliability studies of nuclear safety systems performed to date is employed. Results of a quantitative determination of the unvailability of the accumulator and the containment spray injection systems are presented. These results are also compared to those reported in WASH-1400. (E.G.) [pt

  20. Contextual-Analysis for Infrastructure Awareness Systems

    DEFF Research Database (Denmark)

    Ramos, Juan David Hincapie; Tabard, Aurelien; Alt, Florian

    Infrastructures are persistent socio-technical systems used to deliver different kinds of services. Researchers have looked into how awareness of infrastructures in the areas of sustainability [6, 10] and software appropriation [11] can be provided. However, designing infrastructure-aware systems...... has specific requirements, which are often ignored. In this paper we explore the challenges when developing infrastructure awareness systems based on contextual analysis, and propose guidelines for enhancing the design process....

  1. A Hybrid System for Subjectivity Analysis

    Directory of Open Access Journals (Sweden)

    Samir Rustamov

    2018-01-01

    Full Text Available We suggested different structured hybrid systems for the sentence-level subjectivity analysis based on three supervised machine learning algorithms, namely, Hidden Markov Model, Fuzzy Control System, and Adaptive Neuro-Fuzzy Inference System. The suggested feature extraction algorithm in our experiment computes a feature vector using statistical textual terms frequencies in a training dataset not having the use of any lexical knowledge except tokenization. Taking into consideration this fact, the above-mentioned methods may be employed in other languages as these methods do not utilize the morphological, syntactical, and lexical analysis in the classification problems.

  2. The twilight of the training analysis system.

    Science.gov (United States)

    Kernberg, Otto F

    2014-04-01

    This paper briefly reviews challenges to psychoanalysis at this time, including those derived from both external, societal origins and internal psychoanalytic problems. It focuses attention on serious conflicts around psychoanalytic education, and refers to the training analysis system as a central problem determining fundamental constraints on present-day psychoanalytic education. These constraints are examined in some detail, and the general advantages and disadvantages of the training analysis system are outlined. The effects of all these dynamics on the administrative organization of the American Psychoanalytic Association are explored, and a proposal for a fundamental reorganization of our educational system to resolve the correspondent problems is outlined.

  3. Limitations of systemic accident analysis methods

    Directory of Open Access Journals (Sweden)

    Casandra Venera BALAN

    2016-12-01

    Full Text Available In terms of system theory, the description of complex accidents is not limited to the analysis of the sequence of events / individual conditions, but highlights nonlinear functional characteristics and frames human or technical performance in relation to normal functioning of the system, in safety conditions. Thus, the research of the system entities as a whole is no longer an abstraction of a concrete situation, but an exceeding of the theoretical limits set by analysis based on linear methods. Despite the issues outlined above, the hypothesis that there isn’t a complete method for accident analysis is supported by the nonlinearity of the considered function or restrictions, imposing a broad vision of the elements introduced in the analysis, so it can identify elements corresponding to nominal parameters or trigger factors.

  4. MARS: Microarray analysis, retrieval, and storage system

    Directory of Open Access Journals (Sweden)

    Scheideler Marcel

    2005-04-01

    Full Text Available Abstract Background Microarray analysis has become a widely used technique for the study of gene-expression patterns on a genomic scale. As more and more laboratories are adopting microarray technology, there is a need for powerful and easy to use microarray databases facilitating array fabrication, labeling, hybridization, and data analysis. The wealth of data generated by this high throughput approach renders adequate database and analysis tools crucial for the pursuit of insights into the transcriptomic behavior of cells. Results MARS (Microarray Analysis and Retrieval System provides a comprehensive MIAME supportive suite for storing, retrieving, and analyzing multi color microarray data. The system comprises a laboratory information management system (LIMS, a quality control management, as well as a sophisticated user management system. MARS is fully integrated into an analytical pipeline of microarray image analysis, normalization, gene expression clustering, and mapping of gene expression data onto biological pathways. The incorporation of ontologies and the use of MAGE-ML enables an export of studies stored in MARS to public repositories and other databases accepting these documents. Conclusion We have developed an integrated system tailored to serve the specific needs of microarray based research projects using a unique fusion of Web based and standalone applications connected to the latest J2EE application server technology. The presented system is freely available for academic and non-profit institutions. More information can be found at http://genome.tugraz.at.

  5. Vehicle systems: coupled and interactive dynamics analysis

    Science.gov (United States)

    Vantsevich, Vladimir V.

    2014-11-01

    This article formulates a new direction in vehicle dynamics, described as coupled and interactive vehicle system dynamics. Formalised procedures and analysis of case studies are presented. An analytical consideration, which explains the physics of coupled system dynamics and its consequences for dynamics of a vehicle, is given for several sets of systems including: (i) driveline and suspension of a 6×6 truck, (ii) a brake mechanism and a limited slip differential of a drive axle and (iii) a 4×4 vehicle steering system and driveline system. The article introduces a formal procedure to turn coupled system dynamics into interactive dynamics of systems. A new research direction in interactive dynamics of an active steering and a hybrid-electric power transmitting unit is presented and analysed to control power distribution between the drive axles of a 4×4 vehicle. A control strategy integrates energy efficiency and lateral dynamics by decoupling dynamics of the two systems thus forming their interactive dynamics.

  6. Session 6: Dynamic Modeling and Systems Analysis

    Science.gov (United States)

    Csank, Jeffrey; Chapman, Jeffryes; May, Ryan

    2013-01-01

    These presentations cover some of the ongoing work in dynamic modeling and dynamic systems analysis. The first presentation discusses dynamic systems analysis and how to integrate dynamic performance information into the systems analysis. The ability to evaluate the dynamic performance of an engine design may allow tradeoffs between the dynamic performance and operability of a design resulting in a more efficient engine design. The second presentation discusses the Toolbox for Modeling and Analysis of Thermodynamic Systems (T-MATS). T-MATS is a Simulation system with a library containing the basic building blocks that can be used to create dynamic Thermodynamic Systems. Some of the key features include Turbo machinery components, such as turbines, compressors, etc., and basic control system blocks. T-MAT is written in the Matlab-Simulink environment and is open source software. The third presentation focuses on getting additional performance from the engine by allowing the limit regulators only to be active when a limit is danger of being violated. Typical aircraft engine control architecture is based on MINMAX scheme, which is designed to keep engine operating within prescribed mechanical/operational safety limits. Using a conditionally active min-max limit regulator scheme, additional performance can be gained by disabling non-relevant limit regulators

  7. Zero risk fuel fabrication: a systems analysis

    International Nuclear Information System (INIS)

    1979-01-01

    Zero risk is a concept used to ensure that system requirements are developed through a systems approach such that the choice(s) among alternatives represents the balanced viewpoints of performance, achievability and risk. Requirements to ensure characteristics such as stringent accountability, low personnel exposure and etc. are needed to guide the development of component and subsystems for future LMFBR fuel supply systems. To establish a consistent and objective set of requirements, RF and M-TMC has initiated a systems requirements analysis activity. This activity pivots on judgement and experience provided by a Task Force representing industrial companies engaged in fuel fabrication in licensed facilities. The Task Force members are listed in Appendix A. Input developed by this group is presented as a starting point for the systems requirements analysis

  8. Cost benefit analysis of reactor safety systems

    International Nuclear Information System (INIS)

    Maurer, H.A.

    1984-01-01

    Cost/benefit analysis of reactor safety systems is a possibility appropriate to deal with reactor safety. The Commission of the European Communities supported a study on the cost-benefit or cost effectiveness of safety systems installed in modern PWR nuclear power plants. The following systems and their cooperation in emergency cases were in particular investigated in this study: the containment system (double containment), the leakage exhaust and control system, the annulus release exhaust system and the containment spray system. The benefit of a safety system is defined according to its contribution to the reduction of the radiological consequences for the environment after a LOCA. The analysis is so far performed in two different steps: the emergency core cooling system is considered to function properly, failure of the emergency core cooling system is assumed (with the possible consequence of core melt-down) and the results may demonstrate the evidence that striving for cost-effectiveness can produce a safer end result than the philosophy of safety at any cost. (orig.)

  9. Noise and Spurious Tones Management Techniques for Multi-GHz RF-CMOS Frequency Synthesizers Operating in Large Mixed Analog-Digital SOCs

    Directory of Open Access Journals (Sweden)

    Maxim Adrian

    2006-01-01

    Full Text Available This paper presents circuit techniques and power supply partitioning, filtering, and regulation methods aimed at reducing the phase noise and spurious tones in frequency synthesizers operating in large mixed analog-digital system-on-chip (SOC. The different noise and spur coupling mechanisms are presented together with solutions to minimize their impact on the overall PLL phase noise performance. Challenges specific to deep-submicron CMOS integration of multi-GHz PLLs are revealed, while new architectures that address these issues are presented. Layout techniques that help reducing the parasitic noise and spur coupling between digital and analog blocks are described. Combining system-level and circuit-level low noise design methods, low phase noise frequency synthesizers were achieved which are compatible with the demanding nowadays wireless communication standards.

  10. Analysis hierarchical model for discrete event systems

    Science.gov (United States)

    Ciortea, E. M.

    2015-11-01

    The This paper presents the hierarchical model based on discrete event network for robotic systems. Based on the hierarchical approach, Petri network is analysed as a network of the highest conceptual level and the lowest level of local control. For modelling and control of complex robotic systems using extended Petri nets. Such a system is structured, controlled and analysed in this paper by using Visual Object Net ++ package that is relatively simple and easy to use, and the results are shown as representations easy to interpret. The hierarchical structure of the robotic system is implemented on computers analysed using specialized programs. Implementation of hierarchical model discrete event systems, as a real-time operating system on a computer network connected via a serial bus is possible, where each computer is dedicated to local and Petri model of a subsystem global robotic system. Since Petri models are simplified to apply general computers, analysis, modelling, complex manufacturing systems control can be achieved using Petri nets. Discrete event systems is a pragmatic tool for modelling industrial systems. For system modelling using Petri nets because we have our system where discrete event. To highlight the auxiliary time Petri model using transport stream divided into hierarchical levels and sections are analysed successively. Proposed robotic system simulation using timed Petri, offers the opportunity to view the robotic time. Application of goods or robotic and transmission times obtained by measuring spot is obtained graphics showing the average time for transport activity, using the parameters sets of finished products. individually.

  11. Performance Analysis of Photovoltaic Water Heating System

    Directory of Open Access Journals (Sweden)

    Tomas Matuska

    2017-01-01

    Full Text Available Performance of solar photovoltaic water heating systems with direct coupling of PV array to DC resistive heating elements has been studied and compared with solar photothermal systems. An analysis of optimum fixed load resistance for different climate conditions has been performed for simple PV heating systems. The optimum value of the fixed load resistance depends on the climate, especially on annual solar irradiation level. Use of maximum power point tracking compared to fixed optimized load resistance increases the annual yield by 20 to 35%. While total annual efficiency of the PV water heating systems in Europe ranges from 10% for PV systems without MPP tracking up to 15% for system with advanced MPP trackers, the efficiency of solar photothermal system for identical hot water load and climate conditions is more than 3 times higher.

  12. An expert image analysis system for chromosome analysis application

    International Nuclear Information System (INIS)

    Wu, Q.; Suetens, P.; Oosterlinck, A.; Van den Berghe, H.

    1987-01-01

    This paper reports a recent study on applying a knowledge-based system approach as a new attempt to solve the problem of chromosome classification. A theoretical framework of an expert image analysis system is proposed, based on such a study. In this scheme, chromosome classification can be carried out under a hypothesize-and-verify paradigm, by integrating a rule-based component, in which the expertise of chromosome karyotyping is formulated with an existing image analysis system which uses conventional pattern recognition techniques. Results from the existing system can be used to bring in hypotheses, and with the rule-based verification and modification procedures, improvement of the classification performance can be excepted

  13. Guideliness for system modeling: fault tree [analysis

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yoon Hwan; Yang, Joon Eon; Kang, Dae Il; Hwang, Mee Jeong

    2004-07-01

    This document, the guidelines for system modeling related to Fault Tree Analysis(FTA), is intended to provide the guidelines with the analyzer to construct the fault trees in the level of the capability category II of ASME PRA standard. Especially, they are to provide the essential and basic guidelines and the related contents to be used in support of revising the Ulchin 3 and 4 PSA model for risk monitor within the capability category II of ASME PRA standard. Normally the main objective of system analysis is to assess the reliability of system modeled by Event Tree Analysis (ETA). A variety of analytical techniques can be used for the system analysis, however, FTA method is used in this procedures guide. FTA is the method used for representing the failure logic of plant systems deductively using AND, OR or NOT gates. The fault tree should reflect all possible failure modes that may contribute to the system unavailability. This should include contributions due to the mechanical failures of the components, Common Cause Failures (CCFs), human errors and outages for testing and maintenance. This document identifies and describes the definitions and the general procedures of FTA and the essential and basic guidelines for reving the fault trees. Accordingly, the guidelines for FTA will be capable to guide the FTA to the level of the capability category II of ASME PRA standard.

  14. Guideliness for system modeling: fault tree [analysis

    International Nuclear Information System (INIS)

    Lee, Yoon Hwan; Yang, Joon Eon; Kang, Dae Il; Hwang, Mee Jeong

    2004-07-01

    This document, the guidelines for system modeling related to Fault Tree Analysis(FTA), is intended to provide the guidelines with the analyzer to construct the fault trees in the level of the capability category II of ASME PRA standard. Especially, they are to provide the essential and basic guidelines and the related contents to be used in support of revising the Ulchin 3 and 4 PSA model for risk monitor within the capability category II of ASME PRA standard. Normally the main objective of system analysis is to assess the reliability of system modeled by Event Tree Analysis (ETA). A variety of analytical techniques can be used for the system analysis, however, FTA method is used in this procedures guide. FTA is the method used for representing the failure logic of plant systems deductively using AND, OR or NOT gates. The fault tree should reflect all possible failure modes that may contribute to the system unavailability. This should include contributions due to the mechanical failures of the components, Common Cause Failures (CCFs), human errors and outages for testing and maintenance. This document identifies and describes the definitions and the general procedures of FTA and the essential and basic guidelines for reving the fault trees. Accordingly, the guidelines for FTA will be capable to guide the FTA to the level of the capability category II of ASME PRA standard

  15. System analysis: Developing tools for the future

    Energy Technology Data Exchange (ETDEWEB)

    De Jong, K.; clever, J.; Draper, J.V.; Davies, B.; Lonks, A.

    1996-02-01

    This report introduces and evaluates system analysis tools that were developed, or are under development, for the Robotics Technology Development Program (RTDP). Additionally, it discusses system analysis work completed using these tools aimed at completing a system analysis of the retrieval of waste from underground storage tanks on the Hanford Reservation near Richland, Washington. The tools developed and evaluated include a mixture of commercially available tools adapted to RTDP requirements, and some tools developed in house. The tools that are included in this report include: a Process Diagramming Tool, a Cost Modeling Tool, an Amortization Modeling Tool, a graphical simulation linked to the Cost Modeling Tool, a decision assistance tool, and a system thinking tool. Additionally, the importance of performance testing to the RTDP and the results of such testing executed is discussed. Further, the results of the Tank Waste Retrieval (TWR) System Diagram, the TWR Operations Cost Model, and the TWR Amortization Model are presented, and the implication of the results are discussed. Finally, the RTDP system analysis tools are assessed and some recommendations are made regarding continuing development of the tools and process.

  16. Reliability analysis of containment isolation systems

    International Nuclear Information System (INIS)

    Pelto, P.J.; Counts, C.A.

    1984-06-01

    The Pacific Northwest Laboratory (PNL) is reviewing available information on containment systems design, operating experience, and related research as part of a project being conducted by the Division of Systems Integration, US Nuclear Regulatory Commission. The basic objective of this work is to collect and consolidate data relevant to assessing the functional performance of containment isolation systems and to use this data to the extent possible to characterize containment isolation system reliability for selected reference designs. This paper summarizes the results from initial efforts which focused on collection of data from available documents and briefly describes detailed review and analysis efforts which commenced recently. 5 references

  17. Report on analysis of HERBE system

    International Nuclear Information System (INIS)

    1989-07-01

    The objective of this report is the choice of HERBE system configuration and detailed analysis of neutronic characteristics of the chosen configuration. The system is planned to be built at the RB reactor. Neutronic parameters were calculated by computer code VESNA based on transmission probability method using 44 group nuclear data for 28 nuclides. In the first phase, it has been proposed to achieve HERBE system by using fuel elements existing at the RB reactor. It is suggested to build new hybrid system in the RB reactor using new fuel elements that would be produced

  18. Modeling and analysis of stochastic systems

    CERN Document Server

    Kulkarni, Vidyadhar G

    2011-01-01

    Based on the author's more than 25 years of teaching experience, Modeling and Analysis of Stochastic Systems, Second Edition covers the most important classes of stochastic processes used in the modeling of diverse systems, from supply chains and inventory systems to genetics and biological systems. For each class of stochastic process, the text includes its definition, characterization, applications, transient and limiting behavior, first passage times, and cost/reward models. Along with reorganizing the material, this edition revises and adds new exercises and examples. New to the second edi

  19. SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes

    Directory of Open Access Journals (Sweden)

    Thais T. Zampieri

    2015-03-01

    Conclusions: Our study identified the increased hypothalamic expression of SOCS3 as a key mechanism responsible for triggering pregnancy-induced leptin resistance and metabolic adaptations. These findings not only help to explain a common phenomenon of the mammalian physiology, but it may also aid in the development of approaches to prevent and treat gestational metabolic imbalances.

  20. Architectures, Concepts and Architectures for Service Oriented Computing : proceedings of the 1st International Workshop - ACT4SOC 2007

    NARCIS (Netherlands)

    van Sinderen, Marten J.; Unknown, [Unknown

    2007-01-01

    This volume contains the proceedings of the First International Workshop on Architectures, Concepts and Technologies for Service Oriented Computing (ACT4SOC 2007), held on July 22 in Barcelona, Spain, in conjunction with the Second International Conference on Software and Data Technologies (ICSOFT

  1. IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1: Regulation by SOCS3

    International Nuclear Information System (INIS)

    Sun Rui; Jaruga, Barbara; Kulkarni, Shailin; Sun Haoyu; Gao Bin

    2005-01-01

    The precise role of IL-6 in liver regeneration and hepatocyte proliferation is controversial and the role of SOCS3 in liver regeneration remains unknown. Here we show that in vitro treatment with IL-6 inhibited primary mouse hepatocyte proliferation. IL-6 induced p21 cip1 protein expression in primary mouse hepatocytes. Disruption of the p21 cip1 gene abolished the inhibitory effect of IL-6 on cell proliferation. Co-culture with nonparenchymal liver cells diminished IL-6 inhibition of hepatocyte proliferation, which was likely due to IL-6 stimulation of nonparenchymal cells to produce HGF. Finally, IL-6 induced higher levels of p21 cip1 protein expression and a slightly stronger inhibition of cell proliferation in SOCS3 +/- mouse hepatocytes compared to wild-type hepatocytes, while liver regeneration was enhanced and prolonged in SOCS3 +/- mice. Our findings suggest that IL-6 directly inhibits hepatocyte proliferation via a p21 cip1 -dependent mechanism and indirectly enhances hepatocyte proliferation via stimulating nonparenchymal cells to produce HGF. SOCS3 negatively regulates liver regeneration

  2. System based practice: a concept analysis

    Directory of Open Access Journals (Sweden)

    SHAHRAM YAZDANI

    2016-04-01

    Full Text Available Introduction: Systems-Based Practice (SBP is one of the six competencies introduced by the ACGME for physicians to provide high quality of care and also the most challenging of them in performance, training, and evaluation of medical students. This concept analysis clarifies the concept of SBP by identifying its components to make it possible to differentiate it from other similar concepts. For proper training of SBP and to ensure these competencies in physicians, it is necessary to have an operational definition, and SBP’s components must be precisely defined in order to provide valid and reliable assessment tools. Methods: Walker & Avant’s approach to concept analysis was performed in eight stages: choosing a concept, determining the purpose of analysis, identifying all uses of the concept, defining attributes, identifying a model case, identifying borderline, related, and contrary cases, identifying antecedents and consequences, and defining empirical referents. Results: Based on the analysis undertaken, the attributes of SBP includes knowledge of the system, balanced decision between patients’ need and system goals, effective role playing in interprofessional health care team, system level of health advocacy, and acting for system improvement. System thinking and a functional system are antecedents and system goals are consequences. A case model, as well as border, and contrary cases of SBP, has been introduced. Conclusion: The identification of SBP attributes in this study contributes to the body of knowledge in SBP and reduces the ambiguity of this concept to make it possible for applying it in training of different medical specialties. Also, it would be possible to develop and use more precise tools to evaluate SBP competency by using empirical referents of the analysis.

  3. Gaining Insights on the H2–Sorbent Interactions: Robust soc-MOF Platform as a Case Study

    KAUST Repository

    Cairns, Amy

    2016-09-18

    We report on the synthesis and gas adsorption properties (i.e., Ar and H2) of four robust 3-periodic metal–organic frameworks (MOFs) having the targeted soc topology. These cationic MOFs are isostructural to the parent indium-based MOF, In-soc-MOF-1a (for NO3–), previously reported by us, and likewise are constructed from the assembly of rigid μ3-oxygen-centered trinuclear metal carboxylate clusters, [M3O(O2C−)6], where M = In3+ or Fe3+. Each inorganic trinuclear molecular building block (MBB), generated in situ, is bridged by six 3,3′,5,5′-azobenzenetetracarboxylate (ABTC4–) ligands to give the extended (4,6)-connected MOF, soc-MOF. In our previous work, we confirmed that the parent soc-MOF, i.e., In-soc-MOF-1a, possesses unique structural characteristics (e.g., vacant In binding sites and narrow pores with higher localized charge density), which led to exceptional hydrogen (H2) storage capabilities. Therefore, charged MOFs with soc topology can be viewed collectively as an ideal prototypical platform to examine the impact of specific structural parameters on H2–MOF interactions via systematic gas adsorption studies. We infer that enhanced binding of molecular H2 is primarily governed by the presence and type of vacant metal centers (i.e., Fe was shown to exhibit stronger H2–MOF interactions at low H2 loading compared to the In analogues). These findings are evident from the associated isosteric heat of adsorption (Qst) at low loadings and inelastic neutron scattering (INS) experiments of the rotational transitions of sorbed H2, as well as, temperature-programmed desorption (TPD) studies (for a select compound). The importance of localized charge density is also highlighted, where the extra-framework nitrate anions in the Fe-soc-MOF-1a (for NO3–) facilitate enhanced binding affinities as compared to the chloride analogue.

  4. Land use changing SOC pool: A field investigation from four catchments on the Loess Plateau in China

    Science.gov (United States)

    Guo, Shengli; Wang, Rui; Hu, Yaxian

    2017-04-01

    The Loess Plateau in China has long been known for severe erosion, a degraded ecosystem and heavy sediment delivery to the Yellow River. Apart from, the highly erodible loess soil and the hilly geomorphology, intensive cultivation has been caused such most destructive human activities. This made the Loess Plateau once the least fertile region in China with extreme poverty. To restore soil fertility and ecosystem sustainability, a national-level project was launched in 1990s to encourage land use changes via afforestation or conversion of cropland back to grassland or woodland. After nearly three decades of land use conversion, the SOC pool in the soil can be expected to have substantially changed. However, climate conditions, geomorphic types and soil properties were spatially distinctive across the Loess Plateau. Their individual as well interactive impacts on changes of soil carbon pool during land use conversions must thus be properly accounted for. In this study, four watersheds distributed over the Loess Plateau were investigated. The four watersheds mainly consisted of three geomorphic types: wide gully, loess ridge, and round knoll. On each geomorphic feature, three land use types prevailed: cropland, grassland and woodland. In total, 695 soil samples were taken from the top 20 cm of the four watersheds during 2010 and 2011. Our results show: 1) Degrees of erosion hugely differed among the four watersheds, with Catchment A (hilly) having three times more erosion modulus than the least eroded Catchment D (gully) (12000 vs. 1800 Mg per km2 per year). 2) The increasing SOC content from 4 mg g-1 at Catchment A to 8.1 mg g-1 at Catchment D agreed well with their decreasing erosion, suggesting that geomorphology induced erosion history was the predominant factor to set the general level of watershed-scale SOC reservoir. 3) Within each watershed, grassland and woodland consistently had at least 34% more SOC than cropland, demonstrating the influence of land use

  5. Chemical detection, identification, and analysis system

    International Nuclear Information System (INIS)

    Morel, R.S.; Gonzales, D.; Mniszewski, S.

    1990-01-01

    The chemical detection, identification, and analysis system (CDIAS) has three major goals. The first is to display safety information regarding chemical environment before personnel entry. The second is to archive personnel exposure to the environment. Third, the system assists users in identifying the stage of a chemical process in progress and suggests safety precautions associated with that process. In addition to these major goals, the system must be sufficiently compact to provide transportability, and it must be extremely simple to use in order to keep user interaction at a minimum. The system created to meet these goals includes several pieces of hardware and the integration of four software packages. The hardware consists of a low-oxygen, carbon monoxide, explosives, and hydrogen sulfide detector; an ion mobility spectrometer for airborne vapor detection; and a COMPAQ 386/20 portable computer. The software modules are a graphics kernel, an expert system shell, a data-base management system, and an interface management system. A supervisory module developed using the interface management system coordinates the interaction of the other software components. The system determines the safety of the environment using conventional data acquisition and analysis techniques. The low-oxygen, carbon monoxide, hydrogen sulfide, explosives, and vapor detectors are monitored for hazardous levels, and warnings are issued accordingly

  6. The ASDEX integrated data analysis system AIDA

    International Nuclear Information System (INIS)

    Grassie, K.; Gruber, O.; Kardaun, O.; Kaufmann, M.; Lackner, K.; Martin, P.; Mast, K.F.; McCarthy, P.J.; Mertens, V.; Pohl, D.; Rang, U.; Wunderlich, R.

    1989-11-01

    Since about two years, the ASDEX integrated data analysis system (AIDA), which combines the database (DABA) and the statistical analysis system (SAS), is successfully in operation. Besides a considerable, but meaningful, reduction of the 'raw' shot data, it offers the advantage of carefully selected and precisely defined datasets, which are easily accessible for informative tabular data overviews (DABA), and multi-shot analysis (SAS). Even rather complicated, statistical analyses can be performed efficiently within this system. In this report, we want to summarise AIDA's main features, give some details on its set-up and on the physical models which have been used for the derivation of the processed data. We also give short introduction how to use DABA and SAS. (orig.)

  7. Residual energy applications program systems analysis report

    Energy Technology Data Exchange (ETDEWEB)

    Yngve, P.W.

    1980-10-01

    Current DOE plans call for building an Energy Applied Systems Test (EAST) Facility at the Savannah River Plant in close proximity to the 140 to 150/sup 0/F waste heat from one of several operating nuclear reactors. The waste water flow from each reactor, approximately 165,000 gpm, provides a unique opportunity to test the performance and operating characteristics of large-scale waste heat power generation and heat pump system concepts. This report provides a preliminary description of the potential end-use market, parametric data on heat pump and the power generation system technology, a preliminary listing of EAST Facility requirements, and an example of an integrated industrial park utilizing the technology to maximize economic pay back. The parametric heat pump analysis concluded that dual-fluid Rankine cycle heat pumps with capacities as high as 400 x 10/sup 6/ Btu/h, can utilize large sources of low temperature residual heat to provide 300/sup 0/F saturatd steam for an industrial park. The before tax return on investment for this concept is 36.2%. The analysis also concluded that smaller modular heat pumps could fulfill the same objective while sacrificing only a moderate rate of return. The parametric power generation analysis concluded that multi-pressure Rankine cycle systems not only are superior to single pressure systems, but can also be developed for large systems (approx. = 17 MW/sub e/). This same technology is applicable to smaller systems at the sacrifice of higher investment per unit output.

  8. RAMS (Risk Analysis - Modular System) methodology

    Energy Technology Data Exchange (ETDEWEB)

    Stenner, R.D.; Strenge, D.L.; Buck, J.W. [and others

    1996-10-01

    The Risk Analysis - Modular System (RAMS) was developed to serve as a broad scope risk analysis tool for the Risk Assessment of the Hanford Mission (RAHM) studies. The RAHM element provides risk analysis support for Hanford Strategic Analysis and Mission Planning activities. The RAHM also provides risk analysis support for the Hanford 10-Year Plan development activities. The RAMS tool draws from a collection of specifically designed databases and modular risk analysis methodologies and models. RAMS is a flexible modular system that can be focused on targeted risk analysis needs. It is specifically designed to address risks associated with overall strategy, technical alternative, and `what if` questions regarding the Hanford cleanup mission. RAMS is set up to address both near-term and long-term risk issues. Consistency is very important for any comparative risk analysis, and RAMS is designed to efficiently and consistently compare risks and produce risk reduction estimates. There is a wide range of output information that can be generated by RAMS. These outputs can be detailed by individual contaminants, waste forms, transport pathways, exposure scenarios, individuals, populations, etc. However, they can also be in rolled-up form to support high-level strategy decisions.

  9. Plant growth controls short-term changes in soil organic carbon (SOC) stocks of croplands - new insights from the CarboZALF experiment

    Science.gov (United States)

    Hoffmann, Mathias; Jurisch, Nicole; Garcia Alba, Joana; Albiac Borraz, Elisa; Schmidt, Marten; Verch, Gernot; Sommer, Michael; Augustin, Jürgen

    2016-04-01

    The long-term influence of crop rotations, climate conditions or soil type on soil organic carbon stock (SOC) patterns and gaseous C emissions of agricultural landscapes is widely recognized. However, the question of short-term seasonal changes in SOC within these areas remains unclear. A main reason for this is the detection problem of temporal and spatial variability in gaseous C exchange and thus, changes in SOC stocks (ΔSOC) in a high resolution. This study introduces dynamic C balances as a method to obtain seasonal changes in SOC stocks. Dynamic C balances were calculated by a combination of automatic chamber CO2 exchange measurements and empirical biomass models. Measurements were performed for three consecutive years at a colluvial depression (Colluvic Regosol) in the hummocky ground moraine landscape of NE Germany (CarboZALF experimental site). The investigated crop rotation was maize, winter fodder rye, maize, winter fodder rye, and sudangrass. The site is characterized by a gradient in ground water level (GWL) and related spatial heterogeneity in soil properties, such as SOC as well as soil nitrogen (Nt) stocks. Modelled dynamic C balances reveal that up to 79% of the standard deviation of estimated annual ΔSOC between single chambers emerged during the main period of crop growth (three months in summer). No significant changes in ΔSOC were detected outside the growing season. Instead, differences between chambers remain constant despite ΔSOC dynamics. Environmental variables (Nt stocks of Ap horizon and GWL), affecting plant-mediated C sequestration, explained up to 95% of temporal and spatial variability in CO2 exchange and ΔSOC. Thus, plant activities were the major catalyst for small scale differences in annual ΔSOC of croplands.

  10. Assessment of the Economic Impact of Belimumab for the Treatment of Systemic Lupus Erythematosus in the Italian Setting: A Cost-Effectiveness Analysis.

    Science.gov (United States)

    Pierotti, Francesca; Palla, Ilaria; Treur, Maarten; Pippo, Lara; Turchetti, Giuseppe

    2015-01-01

    The purpose of this analysis is to evaluate the cost-effectiveness of belimumab, a new biological treatment specifically developed for the treatment of Systemic Lupus Erythematosus (SLE), in the Italian setting. SLE is a chronic non-organ specific autoimmune disease characterized by a disregulation of the immune system that involves many organs and systems. A cost-effectiveness micro-simulation model with a lifetime horizon originally developed for the UK was adapted to the Italian setting. The analysis compared Standard of Care (SoC) alone vs belimumab plus SoC from a National Healthcare Service (NHS) and societal perspective. Health-economic consequences of treatments and organ damage progression were calculated. When available, Italian data were used, otherwise UK costs were converted using Purchasing Power Parities (PPPs). Utility values were based on the EQ-5D™ assessments in the belimumab clinical trials (BLISS 52 and 76). Results were discounted with 3% for costs and effects. A maximum belimumab treatment duration of 6 years was assumed and wastage costs were considered. Cost per life year gained (Incremental Cost-Effectiveness Ratio, ICER) and cost per Quality Adjusted Life Year (QALY) (Incremental Cost-Utility Ratio, ICUR) were €22,990 and €32,859, respectively. These values reduced to €20,119 and €28,754, respectively, when indirect costs were included. It may be concluded that in the Italian setting and according to the guidelines of the Italian Association of Health Economics (IAHE), belimumab was shown to be cost-effective, in terms of both ICER and ICUR, (€25-40,000/QALY).

  11. Assessment of the Economic Impact of Belimumab for the Treatment of Systemic Lupus Erythematosus in the Italian Setting: A Cost-Effectiveness Analysis.

    Directory of Open Access Journals (Sweden)

    Francesca Pierotti

    Full Text Available The purpose of this analysis is to evaluate the cost-effectiveness of belimumab, a new biological treatment specifically developed for the treatment of Systemic Lupus Erythematosus (SLE, in the Italian setting. SLE is a chronic non-organ specific autoimmune disease characterized by a disregulation of the immune system that involves many organs and systems.A cost-effectiveness micro-simulation model with a lifetime horizon originally developed for the UK was adapted to the Italian setting. The analysis compared Standard of Care (SoC alone vs belimumab plus SoC from a National Healthcare Service (NHS and societal perspective. Health-economic consequences of treatments and organ damage progression were calculated. When available, Italian data were used, otherwise UK costs were converted using Purchasing Power Parities (PPPs. Utility values were based on the EQ-5D™ assessments in the belimumab clinical trials (BLISS 52 and 76. Results were discounted with 3% for costs and effects. A maximum belimumab treatment duration of 6 years was assumed and wastage costs were considered.Cost per life year gained (Incremental Cost-Effectiveness Ratio, ICER and cost per Quality Adjusted Life Year (QALY (Incremental Cost-Utility Ratio, ICUR were €22,990 and €32,859, respectively. These values reduced to €20,119 and €28,754, respectively, when indirect costs were included.It may be concluded that in the Italian setting and according to the guidelines of the Italian Association of Health Economics (IAHE, belimumab was shown to be cost-effective, in terms of both ICER and ICUR, (€25-40,000/QALY.

  12. Overexpression of DOSOC1, an ortholog of Arabidopsis SOC1, promotes flowering in the orchid Dendrobium Chao Parya Smile.

    Science.gov (United States)

    Ding, Lihua; Wang, Yanwen; Yu, Hao

    2013-04-01

    SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1) encodes a MADS-box protein that plays an essential role in integrating multiple flowering signals to regulate the transition from vegetative to reproductive development in the model plant Arabidopsis. Although SOC1-like genes have been isolated in various angiosperms, its orthologs in Orchidaceae, one of the largest families of flowering plants, are so far unknown. To investigate the regulatory mechanisms of flowering time control in orchids, we isolated a SOC1-like gene, DOSOC1, from Dendrobium Chao Praya Smile. DOSOC1 was highly expressed in reproductive organs, including inflorescence apices, pedicels, floral buds and open flowers. Its expression significantly increased in whole plantlets during the transition from vegetative to reproductive development, which usually occurred after 8 weeks of culture in Dendrobium Chao Praya Smile. In the shoot apex at the floral transitional stage, DOSOC1 was particularly expressed in emerging floral meristems. Overexpression of DOSOC1 in wild-type Arabidopsis plants resulted in early flowering, which was coupled with the up-regulation of two other flowering promoters, AGAMOUS-LIKE 24 and LEAFY. In addition, overexpression of DOSOC1 was able partially to complement the late-flowering phenotype of Arabidopsis soc1-2 loss-of-function mutants. Furthermore, we successfully created seven 35S:DOSOC1 transgenic Dendrobium orchid lines, which consistently exhibited earlier flowering than wild-type orchids. Our results suggest that SOC1-like genes play an evolutionarily conserved role in promoting flowering in the Orchidaceae family, and that DOSOC1 isolated from Dendrobium Chao Praya Smile could serve as an important target for genetic manipulation of flowering time in orchids.

  13. Systems analysis of the CANDU 3 Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Wolfgong, J.R.; Linn, M.A.; Wright, A.L.; Olszewski, M.; Fontana, M.H. [Oak Ridge National Lab., TN (United States)

    1993-07-01

    This report presents the results of a systems failure analysis study of the CANDU 3 reactor design; the study was performed for the US Nuclear Regulatory Commission. As part of the study a review of the CANDU 3 design documentation was performed, a plant assessment methodology was developed, representative plant initiating events were identified for detailed analysis, and a plant assessment was performed. The results of the plant assessment included classification of the CANDU 3 event sequences that were analyzed, determination of CANDU 3 systems that are ``significant to safety,`` and identification of key operator actions for the analyzed events.

  14. An integrated acquisition, display, and analysis system

    International Nuclear Information System (INIS)

    Ahmad, T.; Huckins, R.J.

    1987-01-01

    The design goal of the ND9900/Genuie was to integrate a high performance data acquisition and display subsystem with a state-of-the-art 32-bit supermicrocomputer. This was achieved by integrating a Digital Equipment Corporation MicroVAX II CPU board with acquisition and display controllers via the Q-bus. The result is a tightly coupled processing and analysis system for Pulse Height Analysis and other applications. The system architecture supports distributed processing, so that acquisition and display functions are semi-autonomous, making the VAX concurrently available for applications programs

  15. Essentials of Systems Analysis and Design

    DEFF Research Database (Denmark)

    Kotzab, Herbert

    2010-01-01

    Book review of: Essentials of Systems Analysis and Design: An international version / Joseph V. Valacich, Joey F. George and Jeffrey A. Hoffer. ( Pearson Education Int., 4th edition, 2009. 464 pages. ISBN: 978-0-13-506984-4; 0-13-506984-X)......Book review of: Essentials of Systems Analysis and Design: An international version / Joseph V. Valacich, Joey F. George and Jeffrey A. Hoffer. ( Pearson Education Int., 4th edition, 2009. 464 pages. ISBN: 978-0-13-506984-4; 0-13-506984-X)...

  16. Design and analysis for piping systems

    International Nuclear Information System (INIS)

    Sterkel, H.-P.; Cutrim, J.H.C.

    1981-01-01

    The procedure and the typical techniques that are used in NUCLEN for the design and the calculation of the piping of Nuclear Plants. The classification system are generically described and the analysis techniques which are used for the design and verification of the piping systems, i.e. pressure design for the dimensioning of the wallthicknesses, temperature and dead weight analysis together with determination of support points, are shown. The techniques of dynamic design and analyses are described for earthquake and pressure impulse loadings. (Author) [pt

  17. Digital PIV (DPIV) Software Analysis System

    Science.gov (United States)

    Blackshire, James L.

    1997-01-01

    A software package was developed to provide a Digital PIV (DPIV) capability for NASA LaRC. The system provides an automated image capture, test correlation, and autocorrelation analysis capability for the Kodak Megaplus 1.4 digital camera system for PIV measurements. The package includes three separate programs that, when used together with the PIV data validation algorithm, constitutes a complete DPIV analysis capability. The programs are run on an IBM PC/AT host computer running either Microsoft Windows 3.1 or Windows 95 using a 'quickwin' format that allows simple user interface and output capabilities to the windows environment.

  18. Semiautomatic digital imaging system for cytogenetic analysis

    International Nuclear Information System (INIS)

    Chaubey, R.C.; Chauhan, P.C.; Bannur, S.V.; Kulgod, S.V.; Chadda, V.K.; Nigam, R.K.

    1999-08-01

    The paper describes a digital image processing system, developed indigenously at BARC for size measurement of microscopic biological objects such as cell, nucleus and micronucleus in mouse bone marrow; cytochalasin-B blocked human lymphocytes in-vitro; numerical counting and karyotyping of metaphase chromosomes of human lymphocytes. Errors in karyotyping of chromosomes by the imaging system may creep in due to lack of well-defined position of centromere or extensive bending of chromosomes, which may result due to poor quality of preparation. Good metaphase preparations are mandatory for precise and accurate analysis by the system. Additional new morphological parameters about each chromosome have to be incorporated to improve the accuracy of karyotyping. Though the experienced cytogenetisist is the final judge; however, the system assists him/her to carryout analysis much faster as compared to manual scoring. Further, experimental studies are in progress to validate different software packages developed for various cytogenetic applications. (author)

  19. Parametric systems analysis for ICF hybrid reactors

    International Nuclear Information System (INIS)

    Berwald, D.H.; Maniscalco, J.A.; Chapin, D.L.

    1981-01-01

    Parametric design and systems analysis for inertial confinement fusion-fission hybrids are presented. These results were generated as part of the Electric Power Research Institute (EPRI) sponsored Feasibility Assessment of Fusion-Fission Hybrids, using an Inertial Confinement Fusion (ICF) hybrid power plant design code developed in conjunction with the feasibility assessment. The SYMECON systems analysis code, developed by Westinghouse, was used to generate economic results for symbiotic electricity generation systems consisting of the hybrid and its client Light Water Reactors (LWRs). These results explore the entire fusion parameter space for uranium fast fission blanket hybrids, thorium fast fission blanket hybrids, and thorium suppressed fission blanket types are discussed, and system sensitivities to design uncertainties are explored

  20. Integrated systems analysis of the PIUS reactor

    Energy Technology Data Exchange (ETDEWEB)

    Fullwood, F.; Kroeger, P.; Higgins, J. [Brookhaven National Lab., Upton, NY (United States)] [and others

    1993-11-01

    Results are presented of a systems failure analysis of the PIUS plant systems that are used during normal reactor operation and postulated accidents. This study was performed to provide the NRC with an understanding of the behavior of the plant. The study applied two diverse failure identification methods, Failure Modes Effects & Criticality Analysis (FMECA) and Hazards & Operability (HAZOP) to the plant systems, supported by several deterministic analyses. Conventional PRA methods were also used along with a scheme for classifying events by initiator frequency and combinations of failures. Principal results of this study are: (a) an extensive listing of potential event sequences, grouped in categories that can be used by the NRC, (b) identification of support systems that are important to safety, and (c) identification of key operator actions.

  1. Integrated systems analysis of the PIUS reactor

    International Nuclear Information System (INIS)

    Fullwood, F.; Kroeger, P.; Higgins, J.

    1993-11-01

    Results are presented of a systems failure analysis of the PIUS plant systems that are used during normal reactor operation and postulated accidents. This study was performed to provide the NRC with an understanding of the behavior of the plant. The study applied two diverse failure identification methods, Failure Modes Effects ampersand Criticality Analysis (FMECA) and Hazards ampersand Operability (HAZOP) to the plant systems, supported by several deterministic analyses. Conventional PRA methods were also used along with a scheme for classifying events by initiator frequency and combinations of failures. Principal results of this study are: (a) an extensive listing of potential event sequences, grouped in categories that can be used by the NRC, (b) identification of support systems that are important to safety, and (c) identification of key operator actions

  2. DESIGN PACKAGE 1E SYSTEM SAFETY ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    M. Salem

    1995-06-23

    The purpose of this analysis is to systematically identify and evaluate hazards related to the Yucca Mountain Project Exploratory Studies Facility (ESF) Design Package 1E, Surface Facilities, (for a list of design items included in the package 1E system safety analysis see section 3). This process is an integral part of the systems engineering process; whereby safety is considered during planning, design, testing, and construction. A largely qualitative approach was used since a radiological System Safety Analysis is not required. The risk assessment in this analysis characterizes the accident scenarios associated with the Design Package 1E structures/systems/components(S/S/Cs) in terms of relative risk and includes recommendations for mitigating all identified risks. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into the structure/system/component design, (2) add safety devices and capabilities to the designs that reduce risk, (3) provide devices that detect and warn personnel of hazardous conditions, and (4) develop procedures and conduct training to increase worker awareness of potential hazards, on methods to reduce exposure to hazards, and on the actions required to avoid accidents or correct hazardous conditions.

  3. LHCb Online Log Analysis and Maintenance System

    CERN Document Server

    Garnier, J-C

    2011-01-01

    History has shown, many times computer logs are the only information an administrator may have for an incident, which could be caused either by a malfunction or an attack. Due to the huge amount of logs that are produced from large-scale IT infrastructures, such as LHCb Online, critical information may be overlooked or simply be drowned in a sea of other messages. This clearly demonstrates the need for an automatic system for long-term maintenance and real time analysis of the logs. We have constructed a low cost, fault tolerant centralized logging system which is able to do in-depth analysis and cross-correlation of every log. This system is capable of handling O(10000) different log sources and numerous formats, while trying to keep the overhead as low as possible. It provides log gathering and management, Offline analysis and online analysis. We call Offline analysis the procedure of analyzing old logs for critical information, while Online analysis refer to the procedure of early alerting and reacting. ...

  4. System Reliability Analysis Considering Correlation of Performances

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Saekyeol; Lee, Tae Hee [Hanyang Univ., Seoul (Korea, Republic of); Lim, Woochul [Mando Corporation, Seongnam (Korea, Republic of)

    2017-04-15

    Reliability analysis of a mechanical system has been developed in order to consider the uncertainties in the product design that may occur from the tolerance of design variables, uncertainties of noise, environmental factors, and material properties. In most of the previous studies, the reliability was calculated independently for each performance of the system. However, the conventional methods cannot consider the correlation between the performances of the system that may lead to a difference between the reliability of the entire system and the reliability of the individual performance. In this paper, the joint probability density function (PDF) of the performances is modeled using a copula which takes into account the correlation between performances of the system. The system reliability is proposed as the integral of joint PDF of performances and is compared with the individual reliability of each performance by mathematical examples and two-bar truss example.

  5. System Reliability Analysis Considering Correlation of Performances

    International Nuclear Information System (INIS)

    Kim, Saekyeol; Lee, Tae Hee; Lim, Woochul

    2017-01-01

    Reliability analysis of a mechanical system has been developed in order to consider the uncertainties in the product design that may occur from the tolerance of design variables, uncertainties of noise, environmental factors, and material properties. In most of the previous studies, the reliability was calculated independently for each performance of the system. However, the conventional methods cannot consider the correlation between the performances of the system that may lead to a difference between the reliability of the entire system and the reliability of the individual performance. In this paper, the joint probability density function (PDF) of the performances is modeled using a copula which takes into account the correlation between performances of the system. The system reliability is proposed as the integral of joint PDF of performances and is compared with the individual reliability of each performance by mathematical examples and two-bar truss example.

  6. Analysis and control of underactuated mechanical systems

    CERN Document Server

    Choukchou-Braham, Amal; Djemaï, Mohamed; Busawon, Krishna

    2014-01-01

    This monograph provides readers with tools for the analysis, and control of systems with fewer control inputs than degrees of freedom to be controlled, i.e., underactuated systems. The text deals with the consequences of a lack of a general theory that would allow methodical treatment of such systems and the ad hoc approach to control design that often results, imposing a level of organization whenever the latter is lacking. The authors take as their starting point the construction of a graphical characterization or control flow diagram reflecting the transmission of generalized forces through the degrees of freedom. Underactuated systems are classified according to the three main structures by which this is found to happen—chain, tree, and isolated vertex—and control design procedures proposed. The procedure is applied to several well-known examples of underactuated systems: acrobot; pendubot; Tora system; ball and beam; inertia wheel; and robotic arm with elastic joint. The text is illustrated with MATL...

  7. An Elongin-Cullin-SOCS Box Complex Regulates Stress-Induced Serotonergic Neuromodulation

    Directory of Open Access Journals (Sweden)

    Xicotencatl Gracida

    2017-12-01

    Full Text Available Neuromodulatory cells transduce environmental information into long-lasting behavioral responses. However, the mechanisms governing how neuronal cells influence behavioral plasticity are difficult to characterize. Here, we adapted the translating ribosome affinity purification (TRAP approach in C. elegans to profile ribosome-associated mRNAs from three major tissues and the neuromodulatory dopaminergic and serotonergic cells. We identified elc-2, an Elongin C ortholog, specifically expressed in stress-sensing amphid neuron dual ciliated sensory ending (ADF serotonergic sensory neurons, and we found that it plays a role in mediating a long-lasting change in serotonin-dependent feeding behavior induced by heat stress. We demonstrate that ELC-2 and the von Hippel-Lindau protein VHL-1, components of an Elongin-Cullin-SOCS box (ECS E3 ubiquitin ligase, modulate this behavior after experiencing stress. Also, heat stress induces a transient redistribution of ELC-2, becoming more nuclearly enriched. Together, our results demonstrate dynamic regulation of an E3 ligase and a role for an ECS complex in neuromodulation and control of lasting behavioral states.

  8. Fault tree analysis for reactor systems

    International Nuclear Information System (INIS)

    Crosetti, P.A.

    1971-01-01

    Reliability analysis is playing an increasingly important role in quantitative assessment of system performance for assuring nuclear safety, improving plant performance and plant life, and reducing plant operating costs. The complexity of today's nuclear plants warrant the use of techniques which will provide a comprehensive evaluation of systems in their total context. In particular, fault tree analysis with probability evaluation can play a key role in assuring nuclear safety, in improving plant performance and plant life, and in reducing plant operating costs. The technique provides an all inclusive, versatile mathematical tool for analyzing complex systems. Its application can include a complete plant as well as any of the systems and subsystems. Fault tree analysis provides an objective basis for analyzing system design, performing trade-off studies, analyzing common mode failures, demonstrating compliance with AEC requirements, and justifying system changes or additions. The logic of the approach makes it readily understandable and, therefore, it serves as an effective visibility tool for both engineering and management. (U.S.)

  9. Complex harmonic modal analysis of rotor systems

    International Nuclear Information System (INIS)

    Han, Dong Ju

    2015-01-01

    Complex harmonic analysis for rotor systems has been proposed from the strict complex modal analysis based upon Floquet theory. In this process the harmonic balance method is adopted, effectively associated with conventional eigenvalue analysis. Also, the harmonic coefficients equivalent to dFRFs in harmonic mode has been derived in practice. The modes are classified from identifying the modal characteristics, and the adaptation of harmonic balance method has been proven by comparing the results of the stability analyses from Floque theory and the eigen analysis. The modal features of each critical speed are depicted in quantitatively and qualitatively by showing that the strengths of each component of the harmonic coefficients are estimated from the order of magnitude analysis according to their harmonic patterns. This effectiveness has been verified by comparing with the numerical solutions

  10. Advanced Technology Lifecycle Analysis System (ATLAS)

    Science.gov (United States)

    O'Neil, Daniel A.; Mankins, John C.

    2004-01-01

    Developing credible mass and cost estimates for space exploration and development architectures require multidisciplinary analysis based on physics calculations, and parametric estimates derived from historical systems. Within the National Aeronautics and Space Administration (NASA), concurrent engineering environment (CEE) activities integrate discipline oriented analysis tools through a computer network and accumulate the results of a multidisciplinary analysis team via a centralized database or spreadsheet Each minute of a design and analysis study within a concurrent engineering environment is expensive due the size of the team and supporting equipment The Advanced Technology Lifecycle Analysis System (ATLAS) reduces the cost of architecture analysis by capturing the knowledge of discipline experts into system oriented spreadsheet models. A framework with a user interface presents a library of system models to an architecture analyst. The analyst selects models of launchers, in-space transportation systems, and excursion vehicles, as well as space and surface infrastructure such as propellant depots, habitats, and solar power satellites. After assembling the architecture from the selected models, the analyst can create a campaign comprised of missions spanning several years. The ATLAS controller passes analyst specified parameters to the models and data among the models. An integrator workbook calls a history based parametric analysis cost model to determine the costs. Also, the integrator estimates the flight rates, launched masses, and architecture benefits over the years of the campaign. An accumulator workbook presents the analytical results in a series of bar graphs. In no way does ATLAS compete with a CEE; instead, ATLAS complements a CEE by ensuring that the time of the experts is well spent Using ATLAS, an architecture analyst can perform technology sensitivity analysis, study many scenarios, and see the impact of design decisions. When the analyst is

  11. Structural analysis of fuel handling systems

    Energy Technology Data Exchange (ETDEWEB)

    Lee, L S.S. [Atomic Energy of Canada Ltd., Mississauga, ON (Canada)

    1997-12-31

    The purpose of this paper has three aspects: (i) to review `why` and `what` types of structural analysis, testing and report are required for the fuel handling systems according to the codes, or needed for design of a product, (ii) to review the input requirements for analysis and the analysis procedures, and (iii) to improve the communication between the analysis and other elements of the product cycle. The required or needed types of analysis and report may be categorized into three major groups: (i) Certified Stress Reports for design by analysis, (ii) Design Reports not required for certification and registration, but are still required by codes, and (iii) Design Calculations required by codes or needed for design. Input requirements for structural analysis include: design, code classification, loadings, and jurisdictionary boundary. Examples of structural analysis for the fueling machine head and support structure are given. For improving communication between the structural analysis and the other elements of the product cycle, some areas in the specification of design requirements and load rating are discussed. (author). 6 refs., 1 tab., 4 figs.

  12. Structural analysis of fuel handling systems

    International Nuclear Information System (INIS)

    Lee, L.S.S.

    1996-01-01

    The purpose of this paper has three aspects: (i) to review 'why' and 'what' types of structural analysis, testing and report are required for the fuel handling systems according to the codes, or needed for design of a product, (ii) to review the input requirements for analysis and the analysis procedures, and (iii) to improve the communication between the analysis and other elements of the product cycle. The required or needed types of analysis and report may be categorized into three major groups: (i) Certified Stress Reports for design by analysis, (ii) Design Reports not required for certification and registration, but are still required by codes, and (iii) Design Calculations required by codes or needed for design. Input requirements for structural analysis include: design, code classification, loadings, and jurisdictionary boundary. Examples of structural analysis for the fueling machine head and support structure are given. For improving communication between the structural analysis and the other elements of the product cycle, some areas in the specification of design requirements and load rating are discussed. (author). 6 refs., 1 tab., 4 figs

  13. Systemization of burnup sensitivity analysis code

    International Nuclear Information System (INIS)

    Tatsumi, Masahiro; Hyoudou, Hideaki

    2004-02-01

    To practical use of fact reactors, it is a very important subject to improve prediction accuracy for neutronic properties in LMFBR cores from the viewpoints of improvements on plant efficiency with rationally high performance cores and that on reliability and safety margins. A distinct improvement on accuracy in nuclear core design has been accomplished by development of adjusted nuclear library using the cross-section adjustment method, in which the results of critical experiments of JUPITER and so on are reflected. In the design of large LMFBR cores, however, it is important to accurately estimate not only neutronic characteristics, for example, reaction rate distribution and control rod worth but also burnup characteristics, for example, burnup reactivity loss, breeding ratio and so on. For this purpose, it is desired to improve prediction accuracy of burnup characteristics using the data widely obtained in actual core such as the experimental fast reactor core 'JOYO'. The analysis of burnup characteristics is needed to effectively use burnup characteristics data in the actual cores based on the cross-section adjustment method. So far, development of a analysis code for burnup sensitivity, SAGEP-BURN, has been done and confirmed its effectiveness. However, there is a problem that analysis sequence become inefficient because of a big burden to user due to complexity of the theory of burnup sensitivity and limitation of the system. It is also desired to rearrange the system for future revision since it is becoming difficult to implement new functionalities in the existing large system. It is not sufficient to unify each computational component for some reasons; computational sequence may be changed for each item being analyzed or for purpose such as interpretation of physical meaning. Therefore it is needed to systemize the current code for burnup sensitivity analysis with component blocks of functionality that can be divided or constructed on occasion. For this

  14. Benefit Analysis of Emergency Standby System Promoted to Cogeneration System

    Directory of Open Access Journals (Sweden)

    Shyi-Wen Wang

    2016-07-01

    Full Text Available Benefit analysis of emergency standby system combined with absorption chiller promoted to cogeneration system is introduced. Economic evaluations of such upgraded projects play a major part in the decisions made by investors. Time-of-use rate structure, fuel cost and system constraints are taken into account in the evaluation. Therefore, the problem is formulated as a mixed-integer programming problem. Using two-stage methodology and modified mixed-integer programming technique, a novel algorithm is developed and introduced here to solve the nonlinear optimization problem. The net present value (NPV method is used to evaluate the annual benefits and years of payback for the cogeneration system. The results indicate that upgrading standby generators to cogeneration systems is profitable and should be encouraged, especially for those utilities with insufficient spinning reserves, and moreover, for those having difficulty constructing new power plants.

  15. Marketing analysis support system; Marketing bunseki shien system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-01-10

    Fuji Electric Co., Ltd., in collaboration with Shitashion Japan and Arthur Andersen Ltd., developed a 'marketing analysis support system' which integrally analyzes evaluation factors of various dimensions explaining consumers' purchasing behaviors and which supports business for the efficient operation of product development and demand prediction. This system breaks down products into each evaluation factor from psychological and physical viewpoints, and carries out various kinds of multivariate analysis, thereby making it easy to understand visually, for example, what evaluation factors decide relative positional relations between evaluation factors or between products as well as the position of a product in the whole. Further, more precise marketing analysis and prediction become possible by visually grasping blank areas of products, extent of competition, distribution of products, composition of product series, etc. (translated by NEDO)

  16. Data-mining analysis of the global distribution of soil carbon in observational databases and Earth system models

    Science.gov (United States)

    Hashimoto, Shoji; Nanko, Kazuki; Ťupek, Boris; Lehtonen, Aleksi

    2017-03-01

    Future climate change will dramatically change the carbon balance in the soil, and this change will affect the terrestrial carbon stock and the climate itself. Earth system models (ESMs) are used to understand the current climate and to project future climate conditions, but the soil organic carbon (SOC) stock simulated by ESMs and those of observational databases are not well correlated when the two are compared at fine grid scales. However, the specific key processes and factors, as well as the relationships among these factors that govern the SOC stock, remain unclear; the inclusion of such missing information would improve the agreement between modeled and observational data. In this study, we sought to identify the influential factors that govern global SOC distribution in observational databases, as well as those simulated by ESMs. We used a data-mining (machine-learning) (boosted regression trees - BRT) scheme to identify the factors affecting the SOC stock. We applied BRT scheme to three observational databases and 15 ESM outputs from the fifth phase of the Coupled Model Intercomparison Project (CMIP5) and examined the effects of 13 variables/factors categorized into five groups (climate, soil property, topography, vegetation, and land-use history). Globally, the contributions of mean annual temperature, clay content, carbon-to-nitrogen (CN) ratio, wetland ratio, and land cover were high in observational databases, whereas the contributions of the mean annual temperature, land cover, and net primary productivity (NPP) were predominant in the SOC distribution in ESMs. A comparison of the influential factors at a global scale revealed that the most distinct differences between the SOCs from the observational databases and ESMs were the low clay content and CN ratio contributions, and the high NPP contribution in the ESMs. The results of this study will aid in identifying the causes of the current mismatches between observational SOC databases and ESM outputs

  17. Risk and safety analysis of nuclear systems

    CERN Document Server

    Lee, John C

    2011-01-01

    The book has been developed in conjunction with NERS 462, a course offered every year to seniors and graduate students in the University of Michigan NERS program. The first half of the book covers the principles of risk analysis, the techniques used to develop and update a reliability data base, the reliability of multi-component systems, Markov methods used to analyze the unavailability of systems with repairs, fault trees and event trees used in probabilistic risk assessments (PRAs), and failure modes of systems. All of this material is general enough that it could be used in non-nuclear a

  18. Support system for Neutron Activation Analysis

    International Nuclear Information System (INIS)

    Sasajima, Fumio; Ohtomo, Akitoshi; Sakurai, Fumio; Onizawa, Koji

    1999-01-01

    In the research reactor of JAERI, the Neutron Activation Analysis (NAA) has been utilized as a major part of an irradiation usage. To utilize NAA, research participants are always required to learn necessary technique. Therefore, we started to examine a support system that will enable to carry out INAA easily even by beginners. The system is composed of irradiation device, gamma-ray spectrometer and data analyzing instruments. The element concentration is calculated by using KAYZERO/SOLCOI software with the K 0 standardization method. In this paper, we review on a construction of this INAA support system in JRR-3M of JAERI. (author)

  19. Lyapunov analysis: from dynamical systems theory to applications

    Science.gov (United States)

    Cencini, Massimo; Ginelli, Francesco

    2013-06-01

    [17], von Neumann [18], Krylov [19]3 and Asonov and Sinai [20] on ergodic theory. Lyapunov exponents quantify exponential sensitivity to initial conditions and provide direct access to the entropy production in ergodic systems via the Pesin theory [21]. Further advances have been made possible by the introduction of proper physical invariant measures for certain dissipative systems due to Sinai [22], Ruelle [23] and Bowen [24, 25]. However, it was necessary to wait until the end of the 1970s before the independent works of Shimada and Nagashima [26] and Benettin et al [27] introduced the numerical algorithms required to compute Lyapunov exponents beyond the largest one. The availability of such algorithms and also, at about the same time, of those necessary for the computation of fractal dimensions and entropies by Grassberger and Procaccia [28], made possible the study of chaotic behavior in physically relevant models. Lyapunov analysis, applied to experimental systems [29], was also made possible by a combination of these numerical methods with ideas from nonlinear time series analysis [30]. As a result, it is nowadays widely recognized that Lyapunov exponents are a central tool of chaos theory, crucial for characterizing a number of interesting physical properties including dynamical entropies and fractal dimensions [31]. Their pivotal role in modern dynamical systems theory has been established by a fruitful exchange between a rigorous (and beautiful) mathematical theory and the algorithmic approaches essential for understanding many physical phenomena. From the 1990s to the present, with the concomitant progress in both theoretical understanding and computer capabilities, there has been a progressive shift of interest from low dimensional towards high dimensional systems. This shift towards dynamics characterized by many degrees of freedom, possibly spatially organized and/or with several characteristic temporal scales, has been accompanied by the need for

  20. The ubiquitin ligase Cullin5SOCS2 regulates NDR1/STK38 stability and NF-κB transactivation

    DEFF Research Database (Denmark)

    Paul, Indranil; Batth, Tanveer S; Iglesias-Gato, Diego

    2017-01-01

    SOCS2 is a pleiotropic E3 ligase. Its deficiency is associated with gigantism and organismal lethality upon inflammatory challenge. However, mechanistic understanding of SOCS2 function is dismal due to our unawareness of its protein substrates. We performed a mass spectrometry based proteomic pro...

  1. Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase

    DEFF Research Database (Denmark)

    Andresen, Christina Aaen; Smedegaard, Stine; Sylvestersen, Kathrine Beck

    2014-01-01

    The Ankyrin and SOCS (Suppressor of Cytokine Signaling) box (ASB) family of proteins function as the substrate recognition subunit in a subset of Elongin-Cullin-SOCS (ECS) E3 ubiquitin ligases. Despite counting with 18 members in humans, the identity of the physiological targets of the Asb protei...

  2. Comments on "Precise model measurements versus theoretical prediction of barrier insertion loss in presence of the ground" [J. Acoust. Soc. Am. 73, 44–54 (1983)

    DEFF Research Database (Denmark)

    Rasmussen, Karsten Bo

    1983-01-01

    Some of the theoretical curves in the article by J. Nicolas et al. [J. Acoust. soc. Am. 73, 44–54 (1983)] appear to be erroneous.......Some of the theoretical curves in the article by J. Nicolas et al. [J. Acoust. soc. Am. 73, 44–54 (1983)] appear to be erroneous....

  3. Cognitive Systems Modeling and Analysis of Command and Control Systems

    Science.gov (United States)

    Norlander, Arne

    2012-01-01

    Military operations, counter-terrorism operations and emergency response often oblige operators and commanders to operate within distributed organizations and systems for safe and effective mission accomplishment. Tactical commanders and operators frequently encounter violent threats and critical demands on cognitive capacity and reaction time. In the future they will make decisions in situations where operational and system characteristics are highly dynamic and non-linear, i.e. minor events, decisions or actions may have serious and irreversible consequences for the entire mission. Commanders and other decision makers must manage true real time properties at all levels; individual operators, stand-alone technical systems, higher-order integrated human-machine systems and joint operations forces alike. Coping with these conditions in performance assessment, system development and operational testing is a challenge for both practitioners and researchers. This paper reports on research from which the results led to a breakthrough: An integrated approach to information-centered systems analysis to support future command and control systems research development. This approach integrates several areas of research into a coherent framework, Action Control Theory (ACT). It comprises measurement techniques and methodological advances that facilitate a more accurate and deeper understanding of the operational environment, its agents, actors and effectors, generating new and updated models. This in turn generates theoretical advances. Some good examples of successful approaches are found in the research areas of cognitive systems engineering, systems theory, and psychophysiology, and in the fields of dynamic, distributed decision making and naturalistic decision making.

  4. Business System Planning Project, Alternatives Analysis

    International Nuclear Information System (INIS)

    EVOSEVICH, S.

    2000-01-01

    The CHG Chief Information Officer (CIO) requested a study of alternatives to the current business system computing environment. This Business Systems Planning (BSP) Project Alternatives Analysis document presents an analysis of the current Project Controls, Work Management, and Business Management systems environment and alternative solutions that support the business functions. The project team has collected requirements and priorities from stakeholders in each business area and documented them in the BSP System Requirements Specification (SRS), RPP-6297. The alternatives analysis process identifies and measures possible solutions in each of the business process areas against the requirements as documented in the SRS. The team gathered input from both internal and external sources to identify and grade the possible solutions. This document captures the results of that activity and recommends a suite of software products. This study was to select the best product based on how well the product met the requirements, not to determine the platform or hardware environment that would be used. Additional analysis documentation can be found in BSP project files

  5. Spot analysis system by digitalization and imaging

    International Nuclear Information System (INIS)

    Gedin, F.

    1988-05-01

    Laser isotope separation experiments use series of laser producing several beams with characteristics adapted to physical conditions of photoionization. This paper describes briefly the laser chain and systems for measure and test with more details on analysis of spatial distribution of fluence and superposition of the three beams and alignment on the experiment axis [fr

  6. Counter Trafficking System Development "Analysis Training Program"

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Dennis C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2010-12-01

    This document will detail the training curriculum for the Counter-Trafficking System Development (CTSD) Analysis Modules and Lesson Plans are derived from the United States Military, Department of Energy doctrine and Lawrence Livermore National Laboratory (LLNL), Global Security (GS) S Program.

  7. System optimization by fault tree analysis

    International Nuclear Information System (INIS)

    Krieger, G.

    1985-01-01

    Reliability evaluation are performed during design phasis as well as during erection phasis. Sensitivity analysis are performed to evaluate the balance of system. A suitable representation allows cost and related effect to be directly determined. Thus there is an advantage for decision making where as qualitative evaluations do not give so much insight. (orig.) [de

  8. Requirement analysis for autonomous systems and intelligent ...

    African Journals Online (AJOL)

    user

    Danish Power System and a requirement analysis for the use of intelligent agents and ..... tries to make an optimal islanding plan at this state and tries to blackstart. ... 4 Foundation for Physical Intelligent Agents (FIPA): http://www.fipa.org ...

  9. Computer-automated neutron activation analysis system

    International Nuclear Information System (INIS)

    Minor, M.M.; Garcia, S.R.

    1983-01-01

    An automated delayed neutron counting and instrumental neutron activation analysis system has been developed at Los Alamos National Laboratory's Omega West Reactor (OWR) to analyze samples for uranium and 31 additional elements with a maximum throughput of 400 samples per day. 5 references

  10. Mean value analysis for polling systems

    NARCIS (Netherlands)

    Winands, E.M.M.; Adan, I.J.B.F.; Houtum, van G.J.J.A.N.

    2005-01-01

    The present paper deals with the problem of calculating mean delays in polling systems with either exhaustive or gated service. We develop a mean value analysis (MVA) to compute these delay figures. The merits of MVA are in its intrinsic simplicity and its intuitively appealing derivation. As a

  11. Mean value analysis for polling systems

    NARCIS (Netherlands)

    Winands, E.M.M.; Adan, I.J.B.F.; Houtum, van G.J.J.A.N.

    2006-01-01

    The present paper deals with the problem of calculating mean delays in polling systems with either exhaustive or gated service. We develop a mean value analysis (MVA) to compute these delay figures. The merits of MVA are in its intrinsic simplicity and its intuitively appealing derivation. As a

  12. Tillage practices and straw-returning methods affect topsoil bacterial community and organic C under a rice-wheat cropping system in central China

    Science.gov (United States)

    Guo, Lijin; Zheng, Shixue; Cao, Cougui; Li, Chengfang

    2016-09-01

    The objective of this study was to investigate how the relationships between bacterial communities and organic C (SOC) in topsoil (0-5 cm) are affected by tillage practices [conventional intensive tillage (CT) or no-tillage (NT)] and straw-returning methods [crop straw returning (S) or removal (NS)] under a rice-wheat rotation in central China. Soil bacterial communities were determined by high-throughput sequencing technology. After two cycles of annual rice-wheat rotation, compared with CT treatments, NT treatments generally had significantly more bacterial genera and monounsaturated fatty acids/saturated fatty acids (MUFA/STFA), but a decreased gram-positive bacteria/gram-negative bacteria ratio (G+/G-). S treatments had significantly more bacterial genera and MUFA/STFA, but had decreased G+/G- compared with NS treatments. Multivariate analysis revealed that Gemmatimonas, Rudaea, Spingomonas, Pseudomonas, Dyella, Burkholderia, Clostridium, Pseudolabrys, Arcicella and Bacillus were correlated with SOC, and cellulolytic bacteria (Burkholderia, Pseudomonas, Clostridium, Rudaea and Bacillus) and Gemmationas explained 55.3% and 12.4% of the variance in SOC, respectively. Structural equation modeling further indicated that tillage and residue managements affected SOC directly and indirectly through these cellulolytic bacteria and Gemmationas. Our results suggest that Burkholderia, Pseudomonas, Clostridium, Rudaea, Bacillus and Gemmationas help to regulate SOC sequestration in topsoil under tillage and residue systems.

  13. A Concept Analysis of Systems Thinking.

    Science.gov (United States)

    Stalter, Ann M; Phillips, Janet M; Ruggiero, Jeanne S; Scardaville, Debra L; Merriam, Deborah; Dolansky, Mary A; Goldschmidt, Karen A; Wiggs, Carol M; Winegardner, Sherri

    2017-10-01

    This concept analysis, written by the National Quality and Safety Education for Nurses (QSEN) RN-BSN Task Force, defines systems thinking in relation to healthcare delivery. A review of the literature was conducted using five databases with the keywords "systems thinking" as well as "nursing education," "nursing curriculum," "online," "capstone," "practicum," "RN-BSN/RN to BSN," "healthcare organizations," "hospitals," and "clinical agencies." Only articles that focused on systems thinking in health care were used. The authors identified defining attributes, antecedents, consequences, and empirical referents of systems thinking. Systems thinking was defined as a process applied to individuals, teams, and organizations to impact cause and effect where solutions to complex problems are accomplished through collaborative effort according to personal ability with respect to improving components and the greater whole. Four primary attributes characterized systems thinking: dynamic system, holistic perspective, pattern identification, and transformation. Using the platform provided in this concept analysis, interprofessional practice has the ability to embrace planned efforts to improve critically needed quality and safety initiatives across patients' lifespans and all healthcare settings. © 2016 Wiley Periodicals, Inc.

  14. Error propagation analysis for a sensor system

    International Nuclear Information System (INIS)

    Yeater, M.L.; Hockenbury, R.W.; Hawkins, J.; Wilkinson, J.

    1976-01-01

    As part of a program to develop reliability methods for operational use with reactor sensors and protective systems, error propagation analyses are being made for each model. An example is a sensor system computer simulation model, in which the sensor system signature is convoluted with a reactor signature to show the effect of each in revealing or obscuring information contained in the other. The error propagation analysis models the system and signature uncertainties and sensitivities, whereas the simulation models the signatures and by extensive repetitions reveals the effect of errors in various reactor input or sensor response data. In the approach for the example presented, the errors accumulated by the signature (set of ''noise'' frequencies) are successively calculated as it is propagated stepwise through a system comprised of sensor and signal processing components. Additional modeling steps include a Fourier transform calculation to produce the usual power spectral density representation of the product signature, and some form of pattern recognition algorithm

  15. Overexpression of an orchid (Dendrobium nobile SOC1/TM3-like ortholog, DnAGL19, in Arabidopsis regulates HOS1-FT expression

    Directory of Open Access Journals (Sweden)

    Xiao-ru eLiu

    2016-02-01

    Full Text Available Flowering in the appropriate season is critical for successful reproduction in angiosperms. The orchid species, Dendrobium nobile, requires vernalization to achieve flowering in the spring, but the underlying regulatory network has not been identified to date. The MADS-box transcription factor DnAGL19 was previously identified in a study of low-temperature treated D. nobile buds and was suggested to regulate vernalization-induced flowering. In this study, phylogenetic analysis of DnAGL9 and the MADS-box containing proteins showed that DnAGL19 is phylogenetically closely related to the SOC1-like protein from orchid Dendrobium Chao Parya Smile, DOSOC1. The orchid clade closed to but is not included into the SOC1-1/TM3 clades associated with either eudicots or monocots, suggesting that DnAGL19 is an SOC1-1/TM3-like ortholog. DnAGL19 was found to be highly expressed in pseudobulbs, leaves, roots and axillary buds but rarely in flowers, and to be substantially upregulated in axillary buds by prolonged low-temperature treatments. Overexpression of DnAGL19 in Arabidopsis thaliana resulted in a small but significantly reduced time to bolting, suggesting that flowering time was slightly accelerated under normal growth conditions. Consistent with this, the A. thaliana APETELA1 (AP1 gene was expressed at an earlier stage in transgenic lines than in wild type plants, while the FLOWERING LOCUS T (FT gene was suppressed, suggesting that altered regulations on these transcription factors caused the weak promotion of flowering. HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1 (HOS1 was slightly activated under the same conditions, suggesting that the HOS1-FT module may be involved in the DnAGL19-related network. Under vernalization conditions, FT expression was significantly upregulated, whereas HOS1 expression in the transgenic A. thaliana has a level similar to that in wild type. Taken together, these results suggest that DnAGL19 controls the action of the

  16. Efficiency analysis system of material management

    Directory of Open Access Journals (Sweden)

    Bogusław Śliwczyński

    2012-12-01

    Full Text Available Background: Significant scope of enterprise's efficiency management is improving of material management process both the strategic and operational level. The complexity of material flow processes can lead to a threat such as distraction and disintegration of analysis focusing on many different factors influenced on effective sourcing and procurement management, transport and warehousing processes, inventory management, working capital and cash flow management. Material and methods: The presented article focuses on multidimensional and multi-criteria analysis of material management efficiency that is considered as decision support system. Authors have presented results of the research regarding ineffective material management confirm insufficient analytical supporting in various decisions of procurement operations. Results and conclusions: Based on research results authors presented in the article model of efficiency analysis system of material management.

  17. Licensing Support System: Preliminary data scope analysis

    International Nuclear Information System (INIS)

    1989-01-01

    The purpose of this analysis is to determine the content and scope of the Licensing Support System (LSS) data base. Both user needs and currently available data bases that, at least in part, address those needs have been analyzed. This analysis, together with the Preliminary Needs Analysis (DOE, 1988d) is a first effort under the LSS Design and Implementation Contract toward developing a sound requirements foundation for subsequent design work. These reports are preliminary. Further refinements must be made before requirements can be specified in sufficient detail to provide a basis for suitably specific system specifications. This document provides a baseline for what is known at this time. Additional analyses, currently being conducted, will provide more precise information on the content and scope of the LSS data base. 23 refs., 4 figs., 8 tabs

  18. Improving Software Systems By Flow Control Analysis

    Directory of Open Access Journals (Sweden)

    Piotr Poznanski

    2012-01-01

    Full Text Available Using agile methods during the implementation of the system that meets mission critical requirements can be a real challenge. The change in the system built of dozens or even hundreds of specialized devices with embedded software requires the cooperation of a large group of engineers. This article presents a solution that supports parallel work of groups of system analysts and software developers. Deployment of formal rules to the requirements written in natural language enables using formal analysis of artifacts being a bridge between software and system requirements. Formalism and textual form of requirements allowed the automatic generation of message flow graph for the (sub system, called the “big-picture-model”. Flow diagram analysis helped to avoid a large number of defects whose repair cost in extreme cases could undermine the legitimacy of agile methods in projects of this scale. Retrospectively, a reduction of technical debt was observed. Continuous analysis of the “big picture model” improves the control of the quality parameters of the software architecture. The article also tries to explain why the commercial platform based on UML modeling language may not be sufficient in projects of this complexity.

  19. Development of cost-benefit analysis system

    International Nuclear Information System (INIS)

    Shiba, Tsuyoshi; Mishima, Tetsuya; Yuyama, Tomonori; Suzuki, Atsushi

    2001-01-01

    In order to promote the FDR development, it is necessary to see various benefits brought by introduction of FBR from multiple perspectives and have a good grasp of such benefits quantitatively and an adequate R and D investment scale which corresponds with them. In this study, the structured prototype in the previous study was improved to be able to perform cost-benefit analysis. An example of improvement made in the system is addition of subroutine used for comparison between new energy and benefits brought by introduction of FBR with special emphasis on addition of logic for analyzing externality about the new energy. Other improvement examples are modification of the Conventional Year Expense Ratio method of power generation cost to Average Durable Year Cost method, addition of database function and turning input data into database, and reviewing idea on cost by the type of waste material and price of uranium. The cost-benefit analysis system was also restructured utilizing Microsoft ACCESS so that it should have a data base function. As the result of the improvement mentioned above, we expect that the improved cost-benefit analysis system will have higher generality than the system before; therefore, great deal of benefits brought by application of the system in the future is expected. (author)

  20. Analysis and design of energy systems

    International Nuclear Information System (INIS)

    Bajura, R.A.; Marston, C.H.; Tstsaronis, G.

    1989-01-01

    The 1980s saw growing public awareness of environmental issues. Events such as an unusually hot and dry summer in parts of the world, contamination of community drinking water supplies by leakage from abandoned waste disposal sites, and the discovery of a hole in the ozone layer in the upper stratosphere over Antarctica made headlines in the popular press. The long-range impact of these events on the environment or on human health is still being debated by the scientific and technical communities. In the interim, however, it is prudent to mitigate any possible environmental problems by continuing to develop high-efficiency energy utilization systems that are also cost effective and environmentally sound. High-efficiency fossil energy systems have a number of environmental benefits: carbon dioxide production is reduced and this, in turn, reduces the potential environmental insult which may occur during resource extraction or shipping. Thermodynamic analysis coupled with economic analysis is a useful tool to identify practical, high-efficiency systems. The Symposium on the Analysis and Design of Energy Systems is intended to provide a forum to present both advances in analytical techniques for this type of system and case studies applying these techniques