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Sample records for snrnp rich nuclear

  1. Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish

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    Yuan Liu

    2015-01-01

    Full Text Available Purpose. The small nuclear ribonucleoprotein 200 kDa (SNRNP200 gene is a fundamental component for precursor message RNA (pre-mRNA splicing and has been implicated in the etiology of autosomal dominant retinitis pigmentosa (adRP. This study aims to determine the consequences of knocking down Snrnp200 in zebrafish. Methods. Expression of the Snrnp200 transcript in zebrafish was determined via whole mount in situ hybridization. Morpholino oligonucleotide (MO aiming to knock down the expression of Snrnp200 was injected into zebrafish embryos, followed by analyses of aberrant splicing and expression of the U4/U6-U5 tri-small nuclear ribonucleoproteins (snRNPs components and retina-specific transcripts. Systemic changes and retinal phenotypes were further characterized by histological study and immunofluorescence staining. Results. Snrnp200 was ubiquitously expressed in zebrafish. Knocking down Snrnp200 in zebrafish triggered aberrant splicing of the cbln1 gene, upregulation of other U4/U6-U5 tri-snRNP components, and downregulation of a panel of retina-specific transcripts. Systemic defects were found correlated with knockdown of Snrnp200 in zebrafish. Only demorphogenesis of rod photoreceptors was detected in the initial stage, mimicking the disease characteristics of RP. Conclusions. We conclude that knocking down Snrnp200 in zebrafish could alter regular splicing and expression of a panel of genes, which may eventually trigger rod defects.

  2. Cloning of the cDNA for U1 small nuclear ribonucleoprotein particle 70K protein from Arabidopsis thaliana

    Science.gov (United States)

    Reddy, A. S.; Czernik, A. J.; An, G.; Poovaiah, B. W.

    1992-01-01

    We cloned and sequenced a plant cDNA that encodes U1 small nuclear ribonucleoprotein (snRNP) 70K protein. The plant U1 snRNP 70K protein cDNA is not full length and lacks the coding region for 68 amino acids in the amino-terminal region as compared to human U1 snRNP 70K protein. Comparison of the deduced amino acid sequence of the plant U1 snRNP 70K protein with the amino acid sequence of animal and yeast U1 snRNP 70K protein showed a high degree of homology. The plant U1 snRNP 70K protein is more closely related to the human counter part than to the yeast 70K protein. The carboxy-terminal half is less well conserved but, like the vertebrate 70K proteins, is rich in charged amino acids. Northern analysis with the RNA isolated from different parts of the plant indicates that the snRNP 70K gene is expressed in all of the parts tested. Southern blotting of genomic DNA using the cDNA indicates that the U1 snRNP 70K protein is coded by a single gene.

  3. Reconstitution of a functional 7SK snRNP

    Science.gov (United States)

    Brogie, John E.

    2017-01-01

    Abstract The 7SK small nuclear ribonucleoprotein (snRNP) plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb. We optimized conditions for analyzing 7SK RNA by SHAPE and demonstrated a hysteretic effect of magnesium on 7SK folding dynamics including a 7SK GAUC motif switch. We also found evidence that the 5΄ end pairs alternatively with two different regions of 7SK giving rise to open and closed forms that dictate the state of the 7SK motif. We then used recombinant P-TEFb, HEXIM1, LARP7 and MEPCE to reconstruct a functional 7SK snRNP in vitro. Stably associated P-TEFb was highly inhibited, but could still be released and activated by HIV-1 Tat. Notably, P-TEFb association with both in vitro-reconstituted and cellular snRNPs led to similar changes in SHAPE reactivities, confirming that 7SK undergoes a P-TEFb-dependent structural change. We determined that the xRRM of LARP7 binds to the 3΄ stem loop of 7SK and inhibits the methyltransferase activity of MEPCE through a C-terminal MEPCE interaction domain (MID). Inhibition of MEPCE is dependent on the structure of the 3΄ stem loop and the closed form of 7SK RNA. This study provides important insights into intramolecular interactions within the 7SK snRNP. PMID:28431135

  4. Spinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular Dysfunction

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    Maia Lanfranco

    2017-06-01

    Full Text Available Spinal Muscular Atrophy (SMA is a neuromuscular disorder that results from decreased levels of the survival motor neuron (SMN protein. SMN is part of a multiprotein complex that also includes Gemins 2–8 and Unrip. The SMN-Gemins complex cooperates with the protein arginine methyltransferase 5 (PRMT5 complex, whose constituents include WD45, PRMT5 and pICln. Both complexes function as molecular chaperones, interacting with and assisting in the assembly of an Sm protein core onto small nuclear RNAs (snRNAs to generate small nuclear ribonucleoproteins (snRNPs, which are the operating components of the spliceosome. Molecular and structural studies have refined our knowledge of the key events taking place within the crowded environment of cells and the numerous precautions undertaken to ensure the faithful assembly of snRNPs. Nonetheless, it remains unclear whether a loss of chaperoning in snRNP assembly, considered as a “housekeeping” activity, is responsible for the selective neuromuscular phenotype in SMA. This review thus shines light on in vivo studies that point toward disturbances in snRNP assembly and the consequential transcriptome abnormalities as the primary drivers of the progressive neuromuscular degeneration underpinning the disease. Disruption of U1 snRNP or snRNP assembly factors other than SMN induces phenotypes that mirror aspects of SMN deficiency, and splicing defects, described in numerous SMA models, can lead to a DNA damage and stress response that compromises the survival of the motor system. Restoring the correct chaperoning of snRNP assembly is therefore predicted to enhance the benefit of SMA therapeutic modalities based on augmenting SMN expression.

  5. 3′-End processing of histone pre-mRNAs in Drosophila: U7 snRNP is associated with FLASH and polyadenylation factors

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    Sabath, Ivan; Skrajna, Aleksandra; Yang, Xiao-cui; Dadlez, Michał; Marzluff, William F.; Dominski, Zbigniew

    2013-01-01

    3′-End cleavage of animal replication-dependent histone pre-mRNAs is controlled by the U7 snRNP. Lsm11, the largest component of the U7-specific Sm ring, interacts with FLASH, and in mammalian nuclear extracts these two proteins form a platform that recruits the CPSF73 endonuclease and other polyadenylation factors to the U7 snRNP. FLASH is limiting, and the majority of the U7 snRNP in mammalian extracts exists as a core particle consisting of the U7 snRNA and the Sm ring. Here, we purified the U7 snRNP from Drosophila nuclear extracts and characterized its composition by mass spectrometry. In contrast to the mammalian U7 snRNP, a significant fraction of the Drosophila U7 snRNP contains endogenous FLASH and at least six subunits of the polyadenylation machinery: symplekin, CPSF73, CPSF100, CPSF160, WDR33, and CstF64. The same composite U7 snRNP is recruited to histone pre-mRNA for 3′-end processing. We identified a motif in Drosophila FLASH that is essential for the recruitment of the polyadenylation complex to the U7 snRNP and analyzed the role of other factors, including SLBP and Ars2, in 3′-end processing of Drosophila histone pre-mRNAs. SLBP that binds the upstream stem–loop structure likely recruits a yet-unidentified essential component(s) to the processing machinery. In contrast, Ars2, a protein previously shown to interact with FLASH in mammalian cells, is dispensable for processing in Drosophila. Our studies also demonstrate that Drosophila symplekin and three factors involved in cleavage and polyadenylation—CPSF, CstF, and CF Im—are present in Drosophila nuclear extracts in a stable supercomplex. PMID:24145821

  6. Matter radii of light proton-rich and neutron-rich nuclear isotopes

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    Ahmad, Suhel; Usmani, A. A.; Khan, Z. A.

    2017-12-01

    We extract the matter root-mean-square (rms) radii of a wide range of light proton and neutron rich nuclear isotopes (He-Mg) by studying their interaction cross sections (σI) on 12C at intermediate energies within the framework of the Glauber model. The calculations involve the nucleon densities obtained from harmonic-oscillator Slater determinants. The matter rms radii so obtained are compared with those available in the literature. It is demonstrated that the present description of matter densities can be conveniently used to explain the experimental values of σI, and the extracted matter rms radii may be considered an indication of the presence of halos and skins in proton- and neutron-rich nuclei.

  7. An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses.

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    Schreiber, Claire A; Sakuma, Toshie; Izumiya, Yoshihiro; Holditch, Sara J; Hickey, Raymond D; Bressin, Robert K; Basu, Upamanyu; Koide, Kazunori; Asokan, Aravind; Ikeda, Yasuhiro

    2015-08-01

    Adeno-associated viruses (AAV) have evolved to exploit the dynamic reorganization of host cell machinery during co-infection by adenoviruses and other helper viruses. In the absence of helper viruses, host factors such as the proteasome and DNA damage response machinery have been shown to effectively inhibit AAV transduction by restricting processes ranging from nuclear entry to second-strand DNA synthesis. To identify host factors that might affect other key steps in AAV infection, we screened an siRNA library that revealed several candidate genes including the PHD finger-like domain protein 5A (PHF5A), a U2 snRNP-associated protein. Disruption of PHF5A expression selectively enhanced transgene expression from AAV by increasing transcript levels and appears to influence a step after second-strand synthesis in a serotype and cell type-independent manner. Genetic disruption of U2 snRNP and associated proteins, such as SF3B1 and U2AF1, also increased expression from AAV vector, suggesting the critical role of U2 snRNP spliceosome complex in this host-mediated restriction. Notably, adenoviral co-infection and U2 snRNP inhibition appeared to target a common pathway in increasing expression from AAV vectors. Moreover, pharmacological inhibition of U2 snRNP by meayamycin B, a potent SF3B1 inhibitor, substantially enhanced AAV vector transduction of clinically relevant cell types. Further analysis suggested that U2 snRNP proteins suppress AAV vector transgene expression through direct recognition of intact AAV capsids. In summary, we identify U2 snRNP and associated splicing factors, which are known to be affected during adenoviral infection, as novel host restriction factors that effectively limit AAV transgene expression. Concurrently, we postulate that pharmacological/genetic manipulation of components of the spliceosomal machinery might enable more effective gene transfer modalities with recombinant AAV vectors.

  8. Analysis and prediction of leucine-rich nuclear export signals

    DEFF Research Database (Denmark)

    la Cour, Tanja; Kiemer, Lars; Mølgaard, Anne

    2004-01-01

    We present a thorough analysis of nuclear export signals and a prediction server, which we have made publicly available. The machine learning prediction method is a significant improvement over the generally used consensus patterns. Nuclear export signals (NESs) are extremely important regulators...... of the subcellular location of proteins. This regulation has an impact on transcription and other nuclear processes, which are fundamental to the viability of the cell. NESs are studied in relation to cancer, the cell cycle, cell differentiation and other important aspects of molecular biology. Our conclusion from...... this analysis is that the most important properties of NESs are accessibility and flexibility allowing relevant proteins to interact with the signal. Furthermore, we show that not only the known hydrophobic residues are important in defining a nuclear export signals. We employ both neural networks and hidden...

  9. Analysis and prediction of leucine-rich nuclear export signals

    DEFF Research Database (Denmark)

    La Cour, T.; Kiemer, Lars; Mølgaard, Anne

    2004-01-01

    this analysis is that the most important properties of NESs are accessibility and flexibility allowing relevant proteins to interact with the signal. Furthermore, we show that not only the known hydrophobic residues are important in defining a nuclear export signals. We employ both neural networks and hidden......We present a thorough analysis of nuclear export signals and a prediction server, which we have made publicly available. The machine learning prediction method is a significant improvement over the generally used consensus patterns. Nuclear export signals (NESs) are extremely important regulators...... Markov models in the prediction algorithm and verify the method on the most recently discovered NESs. The NES predictor (NetNES) is made available for general use at http://www.cbs.dtu.dk/....

  10. Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients

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    Shanye Yin

    2017-06-01

    Full Text Available Hexanucleotide repeat expansion in the C9ORF72 gene results in production of dipeptide repeat (DPR proteins that may disrupt pre-mRNA splicing in amyotrophic lateral sclerosis (ALS and frontotemporal dementia (FTD patients. At present, the mechanisms underlying this mis-splicing are not understood. Here, we show that addition of proline-arginine (PR and glycine-arginine (GR toxic DPR peptides to nuclear extracts blocks spliceosome assembly and splicing, but not other types of RNA processing. Proteomic and biochemical analyses identified the U2 small nuclear ribonucleoprotein particle (snRNP as a major interactor of PR and GR peptides. In addition, U2 snRNP, but not other splicing factors, mislocalizes from the nucleus to the cytoplasm both in C9ORF72 patient induced pluripotent stem cell (iPSC-derived motor neurons and in HeLa cells treated with the toxic peptides. Bioinformatic studies support a specific role for U2-snRNP-dependent mis-splicing in C9ORF72 patient brains. Together, our data indicate that DPR-mediated dysfunction of U2 snRNP could account for as much as ∼44% of the mis-spliced cassette exons in C9ORF72 patient brains.

  11. Nuclear localization of the dehydrin OpsDHN1 is determined by histidine-rich motif

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    Hernández-Sánchez, Itzell E.; Maruri-López, Israel; Ferrando, Alejandro; Carbonell, Juan; Graether, Steffen P.; Jiménez-Bremont, Juan F.

    2015-01-01

    The cactus OpsDHN1 dehydrin belongs to a large family of disordered and highly hydrophilic proteins known as Late Embryogenesis Abundant (LEA) proteins, which accumulate during the late stages of embryogenesis and in response to abiotic stresses. Herein, we present the in vivo OpsDHN1 subcellular localization by N-terminal GFP translational fusion; our results revealed a cytoplasmic and nuclear localization of the GFP::OpsDHN1 protein in Nicotiana benthamiana epidermal cells. In addition, dimer assembly of OpsDHN1 in planta using a Bimolecular Fluorescence Complementation (BiFC) approach was demonstrated. In order to understand the in vivo role of the histidine-rich motif, the OpsDHN1-ΔHis version was produced and assayed for its subcellular localization and dimer capability by GFP fusion and BiFC assays, respectively. We found that deletion of the OpsDHN1 histidine-rich motif restricted its localization to cytoplasm, but did not affect dimer formation. In addition, the deletion of the S-segment in the OpsDHN1 protein affected its nuclear localization. Our data suggest that the deletion of histidine-rich motif and S-segment show similar effects, preventing OpsDHN1 from getting into the nucleus. Based on these results, the histidine-rich motif is proposed as a targeting element for OpsDHN1 nuclear localization. PMID:26442018

  12. Nuclear localization of the dehydrin OpsDHN1 is determined by histidine-rich motif

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    Itzell Euridice Hernández-Sánchez

    2015-09-01

    Full Text Available The cactus OpsDHN1 dehydrin belongs to a large family of disordered and highly hydrophilic proteins known as Late Embryogenesis Abundant (LEA proteins, which accumulate during the late stages of embryogenesis and in response to abiotic stresses. Herein, we present the in vivo OpsDHN1 subcellular localization by N-terminal GFP translational fusion; our results revealed a cytoplasmic and nuclear localization of the GFP::OpsDHN1 protein in Nicotiana benthamiana epidermal cells. In addition, dimer assembly of OpsDHN1 in planta using a Bimolecular Fluorescence Complementation (BiFC approach was demonstrated. In order to understand the in vivo role of the histidine-rich motif, the OpsDHN1-ΔHis version was produced and assayed for its subcellular localization and dimer capability by GFP fusion and BiFC assays, respectively. We found that deletion of the OpsDHN1 histidine-rich motif restricted its localization to cytoplasm, but did not affect dimer formation. In addition, the deletion of the S-segment in the OpsDHN1 protein affected its nuclear localization. Our data suggest that the deletion of histidine-rich motif and S-segment show similar effects, preventing OpsDHN1 from getting into the nucleus. Based on these results, the histidine rich motif is proposed as a targeting element for OpsDHN1 nuclear localization.

  13. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP.

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    Sébastien Gingras

    2007-08-01

    Full Text Available Gene array analysis has been widely used to identify genes induced during T cell activation. Our studies identified an immediate early gene that is strongly induced in response to IL-2 in mouse T cells which we named cysteine- serine-rich nuclear protein-1 (CSRNP-1. The human ortholog was previously identified as an AXIN1 induced gene (AXUD1. The protein does not contain sequence defined domains or motifs annotated in public databases, however the gene is a member of a family of three mammalian genes that share conserved regions, including cysteine- and serine-rich regions and a basic domain, they encode nuclear proteins, possess transcriptional activation domain and bind the sequence AGAGTG. Consequently we propose the nomenclature of CSRNP-1, -2 and -3 for the family. To elucidate the physiological functions of CSRNP-1, -2 and -3, we generated mice deficient for each of these genes by homologous recombination in embryonic stem cells. Although the CSRNP proteins have the hallmark of transcription factors and CSRNP-1 expression is highly induced by IL-2, deletion of the individual genes had no obvious consequences on normal mouse development, hematopoiesis or T cell functions. However, combined deficiencies cause partial neonatal lethality suggesting that the genes have redundant functions.

  14. LONG-TERM FOLLOW-UP OF 46 PATIENTS WITH ANTI-(U1)SNRNP ANTIBODIES

    NARCIS (Netherlands)

    VANDENHOOGEN, F.H.J.; SPRONK, P.E.; Boerbooms, A.M.T.; Bootsma, H.; DEROOIJ, D.J.R.A.; Kallenberg, Cees; VANDEPUTTE, L.B.A.

    1994-01-01

    The records of 46 patients with anti-(U1)snRNP antibodies and a minimal period of follow-up after first clinical presentation of at least 5 yr were examined with emphasis on symptoms contributing to established criteria of SLE, systemic sclerosis (SSc), RA or dermato- or polymyositis (DM/PM). At

  15. A carboxyl leucine-rich region of parathyroid hormone-related protein is critical for nuclear export.

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    Pache, Jared C; Burton, Douglas W; Deftos, Leonard J; Hastings, Randolph H

    2006-02-01

    PTHrP is an oncofetal protein with distinct proliferative and antiapoptotic roles that are affected by nucleocytoplasmic shuttling. The protein's nuclear export is sensitive to leptomycin B, consistent with a chromosome region maintenance protein 1-dependent pathway. We determined that the 109-139 region of PTHrP was involved in its nuclear export by demonstrating that a C-terminal truncation mutant, residues 1-108, exports at a reduced rate, compared with the wild-type 139 amino acid isoform. We searched for potential nuclear export sequences within the 109-139 region, which is leucine rich. Comparisons with established nuclear export sequences identified a putative consensus signal at residues 126-136. Deletion of this region resulted in nuclear export characteristics that closely matched those of the C-terminal truncation mutant. Confocal microscopic analyses of transfected 293, COS-1, and HeLa cells showed that steady-state nuclear levels of the truncated and deletion mutants were significantly greater than levels of wild-type PTHrP and were unaffected by leptomycin B, unlike the wild-type protein. In addition, both mutants demonstrated greatly reduced nuclear export with assays using nuclear preparations and intact cells. Based on these results, we conclude that the 126-136 amino acid sequence closely approximates the structure of a chromosome region maintenance protein 1-dependent leucine-rich nuclear export signal and is critical for nuclear export of PTHrP.

  16. A Drosophila Model of Spinal Muscular Atrophy Uncouples snRNP Biogenesis Functions of Survival Motor Neuron from Locomotion and Viability Defects

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    Kavita Praveen

    2012-06-01

    Full Text Available The spinal muscular atrophy (SMA protein, survival motor neuron (SMN, functions in the biogenesis of small nuclear ribonucleoproteins (snRNPs. SMN has also been implicated in tissue-specific functions; however, it remains unclear which of these is important for the etiology of SMA. Smn null mutants display larval lethality and show significant locomotion defects as well as reductions in minor-class spliceosomal snRNAs. Despite these reductions, we found no appreciable defects in the splicing of mRNAs containing minor-class introns. Transgenic expression of low levels of either wild-type or an SMA patient-derived form of SMN rescued the larval lethality and locomotor defects; however, snRNA levels were not restored. Thus, the snRNP biogenesis function of SMN is not a major contributor to the phenotype of Smn null mutants. These findings have major implications for SMA etiology because they show that SMN's role in snRNP biogenesis can be uncoupled from the organismal viability and locomotor defects.

  17. Nuclear export of cutaneous HPV8 E7 oncoprotein is mediated by a leucine-rich nuclear export signal via a CRM1 pathway

    Energy Technology Data Exchange (ETDEWEB)

    Onder, Zeynep; Chang, Vivian; Moroianu, Junona, E-mail: moroianu@bc.edu

    2015-01-01

    We recently determined that the nuclear import of cutaneous beta genus HPV8 E7 oncoprotein it is mediated by its zinc-binding domain via direct hydrophobic interactions with the FG nucleoporins Nup62 and Nup153 (Onder and Moroianu, 2014). Here we investigated the nuclear export of HPV8 E7 oncoprotein using confocal microscopy after transfections of HeLa cells with EGFP–8cE7 and mutant plasmids and treatment with Ratjadone A nuclear export inhibitor. We determined that HPV8 E7 contains a leucine-rich nuclear export signal (NES), {sub 76}IRTFQELLF{sub 84}, within its zinc-binding domain that mediates its nuclear export via a CRM1 pathway. We found that HPV8 E7 interacts with CRM1 and that the hydrophobic amino acid residues I76, F79 and L82 of the NES are essential for this interaction and for nuclear export of HPV8 E7 oncoprotein. - Highlights: • HPV8 E7 has a leucine-rich NES within its zinc-binding domain that mediates its nuclear export. • CRM1 nuclear export receptor interacts with HPV8 E7 and mediates its export. • Identification of the critical hydrophobic amino acids of the NES of HPV8 E7.

  18. Evolution of nuclear structure in neutron-rich odd-Zn isotopes and isomers

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    C. Wraith

    2017-08-01

    Full Text Available Collinear laser spectroscopy was performed on Zn (Z=30 isotopes at ISOLDE, CERN. The study of hyperfine spectra of nuclei across the Zn isotopic chain, N=33–49, allowed the measurement of nuclear spins for the ground and isomeric states in odd-A neutron-rich nuclei up to N=50. Exactly one long-lived (>10 ms isomeric state has been established in each 69–79Zn isotope. The nuclear magnetic dipole moments and spectroscopic quadrupole moments are well reproduced by large-scale shell–model calculations in the f5pg9 and fpg9d5 model spaces, thus establishing the dominant term in their wave function. The magnetic moment of the intruder Iπ=1/2+ isomer in 79Zn is reproduced only if the νs1/2 orbital is added to the valence space, as realized in the recently developed PFSDG-U interaction. The spin and moments of the low-lying isomeric state in 73Zn suggest a strong onset of deformation at N=43, while the progression towards 79Zn points to the stability of the Z=28 and N=50 shell gaps, supporting the magicity of 78Ni.

  19. Nuclear reactions of neutron-rich Sn isotopes investigated at relativistic energies at R{sup 3}B

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    Schindler, Fabia; Aumann, Thomas; Horvat, Andrea [TU Darmstadt (Germany); Boretzky, Konstanze [GSI Helmholtzzentrum (Germany); Schrock, Philipp [CNS, University of Tokyo (Japan); Johansen, Jacob [Aarhus University (Denmark); Collaboration: R3B-Collaboration

    2016-07-01

    Nuclei with a large neutron excess are expected to form a neutron-rich surface layer which is often referred to as the neutron skin. The investigation of this phenomenon is of great interest in nuclear-structure physics and offers a possibility to constrain the equation-of-state of neutron-rich matter. Assuming a geometrical description of reaction processes as in the eikonal approximation, nuclear-induced reactions are a good tool to probe the neutron skin. Measured reaction cross sections can be used to constrain the density distributions of protons and neutrons in the nucleus and therefore the neutron-skin thickness. For this purpose, reactions of neutron-rich tin isotopes in the A=124-134 mass range have been measured on a carbon target at the R{sup 3}B-setup at GSI in inverse kinematics in a kinematically complete manner. Preliminary results for the reaction cross sections of {sup 124}Sn are presented.

  20. U2 snRNP is required for expression of the 3' end of genes.

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    Mitsunori Koga

    Full Text Available Pre-mRNA in eukaryotes is subjected to mRNA processing, which includes capping, polyadenylation, and splicing. Transcription and mRNA processing are coupled, and this coupling stimulates mRNA processing; however, the effects of mRNA processing on transcription are not fully understood. In this study, we found that inhibition of U2 snRNP by a splicing inhibitor, spliceostatin A (SSA, or by an antisense oligonucleotide to U2 snRNA, caused gene-specific 3'-end down-regulation. Removal of SSA from the culture media restored expression of the 3' ends of genes, suggesting that U2 snRNP is required for expression of the 3' end of genes. Finally, we found that SSA treatment caused accumulation of Pol II near the 5' end of 3'-end down regulated genes, such as CDK6, SMEK2 and EGFR, indicating that SSA treatment led to transcription elongation arrest on these genes. These findings suggest that U2 snRNP is important for production of full length mRNA probably through regulation of transcription elongation, and that a novel checkpoint mechanism prevents pre-mRNA from accumulating as a result of splicing deficiencies, and thereby prevents production of aberrant proteins that might be translated from pre-mRNAs through the arrest of transcription elongation.

  1. Nuclear shell effects in neutron-rich nuclei around N=20 and N=32,34

    CERN Document Server

    Seidlitz, M

    Nuclear shell effects in neutron-rich nuclei around N=20 and N=32,34 were studied by means of reduced transition probabilities, i.e. B(E2) and B(M1) values. To this end a series of Coulomb-excitation experiments, employing radioactive 31Mg and 29,30Na beams, as well as a precise lifetime experiment of excited states in 56Cr were performed. The collective properties of excited states of 31Mg were the subject of a Coulomb-excitation experiment at REX-ISOLDE, CERN, employing a radioactive 31Mg beam at a beam energy of 3.0 MeV/u. The beam intensity amounted to 3000 ions/s on average. The highly efficient MINIBALL setup was employed, consisting of eight HPGe cluster detectors for gamma-ray detection and a segmented Si-detector for coincident particle detection. The level scheme of 31Mg was extended. Spin and parity assignment of the observed 945 keV state yielded 5/2+ and its de-excitation is dominated by a strong collective M1 transition. Comparison of the transition probabilities of 30,31,32Mg establishes that f...

  2. Nuclear structure studies of neutron-rich heavy nuclei by mass measurements of francium and radium isotopes

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    Rosenbusch, Marco [Ernst-Moritz-Arndt-Universitaet, Institut fuer Physik, 17487 Greifswald (Germany); Collaboration: ISOLTRAP-Collaboration

    2013-07-01

    The mass is a unique property of an atomic nucleus reflecting its binding energy and thus the sum of all interactions at work. Precise measurements of nuclear masses especially of short-lived exotic nuclides provide important input for nuclear structure, nuclear astrophysics, tests of the Standard Model, and weak interaction studies. The Penning-trap mass spectrometer ISOLTRAP at the on-line isotope separator ISOLDE/CERN has been set up for precision mass measurements and continuously improved for accessing more exotic nuclides. The mass uncertainty is typically δm / m=10{sup -8} and the accessible half-life has been reduced to about 50 ms. In this contribution, the results of a measurement campaign of neutron-rich francium and radium isotopes will be presented, i.e. the masses of the isotopic chain of {sup 224-233}Fr and {sup 233,234}Ra, one of the most neutron-rich ensemble obtainable at ISOL facilities. The mass {sup 234}Ra denotes the heaviest mass ever measured with ISOLTRAP. Experimental data in the neutron-rich, heavy mass region is of great interest for studies of structural evolution far from stability, especially because the knowledge from nuclear mass models is scarce. The impact of the new data on the physics in this mass region as well as recent technical developments of ISOLTRAP are discussed.

  3. Identification of two human nuclear proteins that recognise the cytosine-rich strand of human telomeres in vitro

    Science.gov (United States)

    Lacroix, Laurent; Liénard, Hélène; Labourier, Emmanuel; Djavaheri-Mergny, Mojgan; Lacoste, Jérôme; Leffers, Henrik; Tazi, Jamal; Hélène, Claude; Mergny, Jean-Louis

    2000-01-01

    Most studies on the structure of DNA in telomeres have been dedicated to the double-stranded region or the guanosine-rich strand and consequently little is known about the factors that may bind to the telomere cytosine-rich (C-rich) strand. This led us to investigate whether proteins exist that can recognise C-rich sequences. We have isolated several nuclear factors from human cell extracts that specifically bind the C-rich strand of vertebrate telomeres [namely a d(CCCTAA)n repeat] with high affinity and bind double-stranded telomeric DNA with a 100× reduced affinity. A biochemical assay allowed us to characterise four proteins of apparent molecular weights 66–64, 45 and 35 kDa, respectively. To identify these polypeptides we screened a λgt11-based cDNA expression library, obtained from human HeLa cells using a radiolabelled telomeric oligonucleotide as a probe. Two clones were purified and sequenced: the first corresponded to the hnRNP K protein and the second to the ASF/SF2 splicing factor. Confirmation of the screening results was obtained with recombinant proteins, both of which bind to the human telomeric C-rich strand in vitro. PMID:10710423

  4. Molecular genotyping of Colletotrichum species based on arbitrarily primed PCR, A + T-Rich DNA, and nuclear DNA analyses

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    Freeman, S.; Pham, M.; Rodriguez, R.J.

    1993-01-01

    Molecular genotyping of Colletotrichum species based on arbitrarily primed PCR, A + T-rich DNA, and nuclear DNA analyses. Experimental Mycology 17, 309-322. Isolates of Colletotrichum were grouped into 10 separate species based on arbitrarily primed PCR (ap-PCR), A + T-rich DNA (AT-DNA) and nuclear DNA banding patterns. In general, the grouping of Colletotrichum isolates by these molecular approaches corresponded to that done by classical taxonomic identification, however, some exceptions were observed. PCR amplification of genomic DNA using four different primers allowed for reliable differentiation between isolates of the 10 species. HaeIII digestion patterns of AT-DNA also distinguished between species of Colletotrichum by generating species-specific band patterns. In addition, hybridization of the repetitive DNA element (GcpR1) to genomic DNA identified a unique set of Pst 1-digested nuclear DNA fragments in each of the 10 species of Colletotrichum tested. Multiple isolates of C. acutatum, C. coccodes, C. fragariae, C. lindemuthianum, C. magna, C. orbiculare, C. graminicola from maize, and C. graminicola from sorghum showed 86-100% intraspecies similarity based on ap-PCR and AT-DNA analyses. Interspecies similarity determined by ap-PCR and AT-DNA analyses varied between 0 and 33%. Three distinct banding patterns were detected in isolates of C. gloeosporioides from strawberry. Similarly, three different banding patterns were observed among isolates of C. musae from diseased banana.

  5. The economic viability of nuclear power in a fossil-fuel-rich country: Australia

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    Owen, Anthony

    2010-09-15

    This paper assesses the economic viability of investment in nuclear power generation in Australia and factors which may influence government policy towards such investments. It argues that the structure of the grid in Eastern Australia and the nature of the existing generator mix require nuclear technology that has similar attributes to combined cycle gas technology; i.e. modular construction of generating units, load following capability, low unit capital cost, and a general acceptance by the Australian public. The paper concludes that it is only Generation IV nuclear technology that has the potential to be part of Australia's energy mix after 2030.

  6. Lupus autoantibodies to native DNA cross-react with the A and D SnRNP polypeptides

    National Research Council Canada - National Science Library

    Reichlin, M; Martin, A; Taylor-Albert, E; Tsuzaka, K; Zhang, W; Reichlin, M W; Koren, E; Ebling, F M; Tsao, B; Hahn, B H

    1994-01-01

    Antibodies to native DNA (nDNA) in sera from patients with systemic lupus erythematosus have been found to frequently correlate with antibodies to the A and D SnRNP proteins measured in Western blot assays. 40 of 54 SLE (74.1...

  7. Nuclear symmetry energy and the neutron skin in neutron-rich nuclei

    NARCIS (Netherlands)

    Dieperink, AEL; Dewulf, Y; Van Neck, D; Waroquier, M; Rodin, [No Value

    2003-01-01

    The symmetry energy for nuclear matter and its relation to the neutron. skin in finite nuclei is discussed. The symmetry energy as a function of density obtained in a self-consistent Green function approach is presented and compared to the results of other recent theoretical approaches. A partial

  8. Murine and human antibodies to native DNA that cross-react with the A and D SnRNP polypeptides cause direct injury of cultured kidney cells

    National Research Council Canada - National Science Library

    Koren, E; Koscec, M; Wolfson-Reichlin, M; Ebling, FM; Tsao, B; Hahn, BH; Reichlin, M

    1995-01-01

    .... Murine monoclonal and human affinity-purified Abs to native DNA (anti- nDNA) that cross-react with the A and D SnRNP polypeptides were analyzed for direct injurious effects against cultured pig kidney (PK15...

  9. Role of nuclear couplings in the inelastic excitation of weakly-bound neutron-rich nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Dasso, C.H. [Niels Bohr Institute, Copenhagen (Denmark); Lenzi, S.M.; Vitturi, A. [Universita di Padova (Italy)

    1996-12-31

    Much effort is presently devoted to the study of nuclear systems far from the stability line. Particular emphasis has been placed in light systems such as {sup 11}Li, {sup 8}B and others, where the very small binding energy of the last particles causes their density distribution to extend considerably outside of the remaining nuclear core. Some of the properties associated with this feature are expected to characterize also heavier systems in the vicinity of the proton or neutron drip lines. It is by now well established that low-lying concentrations of multipole strength arise from pure configurations in which a peculiar matching between the wavelength of the continuum wavefunction of the particles and the range of the weakly-bound hole states occurs. To this end the authors consider the break-up of a weakly-bound system in a heavy-ion collision and focus attention in the inelastic excitation of the low-lying part of the continuum. They make use of the fact that previous investigations have shown that the multipole response in this region is not of a collective nature and describe their excited states as pure particle-hole configurations. Since the relevant parameter determining the strength distributions is the binding energy of the last bound orbital they find it most convenient to use single-particle wavefunctions generated by a sperical square-well potential with characteristic nuclear dimensions and whose depth has been adjusted to give rise to a situation in which the last occupied neutron orbital is loosely-bound. Spin-orbit couplings are, for the present purpose, ignored. The results of this investigation clearly indicate that nuclear couplings have the predominant role in causing projectile dissociation in many circumstances, even at bombarding energies remarkably below the Coulomb barrier.

  10. Genome-wide analysis of KAP1, the 7SK snRNP complex, and RNA polymerase II

    Directory of Open Access Journals (Sweden)

    Ryan P. McNamara

    2016-03-01

    Full Text Available The transition of RNA polymerase II (Pol II from transcription initiation into productive elongation in eukaryotic cells is regulated by the P-TEFb kinase, which phosphorylates the C-terminal domain of paused Pol II at promoter-proximal regions. Our recent study found that P-TEFb (in an inhibited state bound to the 7SK snRNP complex interacts with the KAP1/TRIM28 transcriptional regulator, and that KAP1 and the 7SK snRNP co-occupy most gene promoters containing paused Pol II. Here we provide a detailed experimental description and analysis of the ChIP-seq datasets that have been deposited into Gene Expression Omnibus (GEO: GS72622, so that independent groups can replicate and expand upon these findings. We propose these datasets would provide valuable information for researchers studying mechanisms of transcriptional regulation including Pol II pausing and pause release.

  11. Caesium-rich micro-particles: A window into the meltdown events at the Fukushima Daiichi Nuclear Power Plant

    Science.gov (United States)

    Furuki, Genki; Imoto, Junpei; Ochiai, Asumi; Yamasaki, Shinya; Nanba, Kenji; Ohnuki, Toshihiko; Grambow, Bernd; Ewing, Rodney C.; Utsunomiya, Satoshi

    2017-02-01

    The nuclear disaster at the Fukushima Daiichi Nuclear Power Plant (FDNPP) in March 2011 caused partial meltdowns of three reactors. During the meltdowns, a type of condensed particle, a caesium-rich micro-particle (CsMP), formed inside the reactors via unknown processes. Here we report the chemical and physical processes of CsMP formation inside the reactors during the meltdowns based on atomic-resolution electron microscopy of CsMPs discovered near the FDNPP. All of the CsMPs (with sizes of 2.0-3.4 μm) comprise SiO2 glass matrices and ~10-nm-sized Zn-Fe-oxide nanoparticles associated with a wide range of Cs concentrations (1.1-19 wt% Cs as Cs2O). Trace amounts of U are also associated with the Zn-Fe oxides. The nano-texture in the CsMPs records multiple reaction-process steps during meltdown in the severe FDNPP accident: Melted fuel (molten core)-concrete interactions (MCCIs), incorporating various airborne fission product nanoparticles, including CsOH and CsCl, proceeded via SiO2 condensation over aggregates of Zn-Fe oxide nanoparticles originating from the failure of the reactor pressure vessels. Still, CsMPs provide a mechanism by which volatile and low-volatility radionuclides such as U can reach the environment and should be considered in the migration model of Cs and radionuclides in the current environment surrounding the FDNPP.

  12. Nuclear structure studies of the neutron-rich Rubidium isotopes using Coulomb excitation

    CERN Multimedia

    Reiter, P; Blazhev, A A; Voulot, D; Meot, V H; Simpson, G S; Georgiev, G P; Gaudefroy, L; Roig, O

    We propose to study the properties of odd-mass neutron-rich rubidium isotopes by the Coulomb-excitation technique, using the Miniball array coupled to the REX-ISOLDE facility. The results from similar measurements from the recent years (e.g. for the odd-mass and the odd-odd Cu isotopes, IS435) have shown the strong potential in such measurements for gaining information both for single-particle-like and collective states in exotic nuclei. Since there is practically no experimental information for excited states in the odd-mass Rb isotopes beyond $^{93}$Rb, the present study should be able to provide new data in a region of spherical ($^{93}$Rb and $^{95}$Rb) as well as well-deformed nuclei ($^{97}$Rb and $^{99}$Rb). Of particular interest is the rapid shape change that occurs when going from $^{95}$Rb (${\\varepsilon}_{2}$=0.06) to $^{97}$Rb (${\\varepsilon}_{2}$=0.3). These results should be of significant astrophysical interest as well, due to the close proximity of the r-process path.

  13. Ab Initio Enhanced calphad Modeling of Actinide-Rich Nuclear Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, Dane [Univ. of Wisconsin, Madison, WI (United States); Yang, Yong Austin [Univ. of Wisconsin, Madison, WI (United States)

    2013-10-28

    The process of fuel recycling is central to the Advanced Fuel Cycle Initiative (AFCI), where plutonium and the minor actinides (MA) Am, Np, and Cm are extracted from spent fuel and fabricated into new fuel for a fast reactor. Metallic alloys of U-Pu-Zr-MA are leading candidates for fast reactor fuels and are the current basis for fast spectrum metal fuels in a fully recycled closed fuel cycle. Safe and optimal use of these fuels will require knowledge of their multicomponent phase stability and thermodynamics (Gibbs free energies). In additional to their use as nuclear fuels, U-Pu-Zr-MA contain elements and alloy phases that pose fundamental questions about electronic structure and energetics at the forefront of modern many-body electron theory. This project will validate state-of-the-art electronic structure approaches for these alloys and use the resulting energetics to model U-Pu-Zr-MA phase stability. In order to keep the work scope practical, researchers will focus on only U-Pu-Zr-{Np,Am}, leaving Cm for later study. The overall objectives of this project are to: Provide a thermodynamic model for U-Pu-Zr-MA for improving and controlling reactor fuels; and, Develop and validate an ab initio approach for predicting actinide alloy energetics for thermodynamic modeling.

  14. ORF73 LANA homologs of RRV and MneRV2 contain an extended RGG/RG-rich nuclear and nucleolar localization signal that interacts directly with importin β1 for non-classical nuclear import.

    Science.gov (United States)

    Howard, Kellie; Cherezova, Lidia; DeMaster, Laura K; Rose, Timothy M

    2017-11-01

    The latency-associated nuclear antigens (LANA) of KSHV and macaque RFHVMn, members of the RV1 rhadinovirus lineage, are closely related with conservation of complex nuclear localization signals (NLS) containing bipartite KR-rich motifs and RG-rich domains, which interact distinctly with importins α and ß1 for nuclear import via classical and non-classical pathways, respectively. RV1 LANAs are expressed in the nucleus of latently-infected cells where they inhibit replication and establish a dominant RV1 latency. Here we show that LANA homologs of macaque RRV and MneRV2 from the more distantly-related RV2 lineage, lack the KR-rich NLS, and instead have a large RG-rich NLS with multiple RG dipeptides and a conserved RGG motif. The RG-NLS interacts uniquely with importin β1, which mediates nuclear import and accumulation of RV2 LANA in the nucleolus. The alternative nuclear import and localization of RV2 LANA homologs may contribute to the dominant RV2 lytic replication phenotype. Copyright © 2017. Published by Elsevier Inc.

  15. Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma.

    Science.gov (United States)

    Yang, Jilong; Annala, Matti; Ji, Ping; Wang, Guowen; Zheng, Hong; Codgell, David; Du, Xiaoling; Fang, Zhiwei; Sun, Baocun; Nykter, Matti; Chen, Kexin; Zhang, Wei

    2014-10-10

    The identification of fusion genes such as SYT-SSX1/SSX2, PAX3-FOXO1, TPM3/TPM4-ALK and EWS-FLI1 in human sarcomas has provided important insight into the diagnosis and targeted therapy of sarcomas. No recurrent fusion has been reported in human osteosarcoma. Transcriptome sequencing was used to characterize the gene fusions and mutations in 11 human osteosarcomas. Nine of 11 samples were found to harbor genetic inactivating alterations in the TP53 pathway. Two recurrent fusion genes associated with the 12q locus, LRP1-SNRNP25 and KCNMB4-CCND3, were identified and validated by RT-PCR, Sanger sequencing and fluorescence in situ hybridization, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas. Expression of LRP1-SNRNP25 fusion gene promoted SAOS-2 osteosarcoma cell migration and invasion. Expression of KCNMB4-CCND3 fusion gene promoted SAOS-2 cell migration. Our study represents the first whole transcriptome analysis of untreated human osteosarcoma. Our discovery of two osteosarcoma specific fusion genes associated with osteosarcoma cellular motility highlights the heterogeneity of osteosarcoma and provides opportunities for new treatment modalities.

  16. Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes

    Directory of Open Access Journals (Sweden)

    Caroline Vindry

    2017-08-01

    Full Text Available Pat1 RNA-binding proteins, enriched in processing bodies (P bodies, are key players in cytoplasmic 5′ to 3′ mRNA decay, activating decapping of mRNA in complex with the Lsm1-7 heptamer. Using co-immunoprecipitation and immunofluorescence approaches coupled with RNAi, we provide evidence for a nuclear complex of Pat1b with the Lsm2-8 heptamer, which binds to the spliceosomal U6 small nuclear RNA (snRNA. Furthermore, we establish the set of interactions connecting Pat1b/Lsm2-8/U6 snRNA/SART3 and additional U4/U6.U5 tri-small nuclear ribonucleoprotein particle (tri-snRNP components in Cajal bodies, the site of snRNP biogenesis. RNA sequencing following Pat1b depletion revealed the preferential upregulation of mRNAs normally found in P bodies and enriched in 3′ UTR AU-rich elements. Changes in >180 alternative splicing events were also observed, characterized by skipping of regulated exons with weak donor sites. Our data demonstrate the dual role of a decapping enhancer in pre-mRNA processing as well as in mRNA decay via distinct nuclear and cytoplasmic Lsm complexes.

  17. The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells

    Science.gov (United States)

    Pabis, Marta; Neufeld, Noa; Steiner, Michaela C.; Bojic, Teodora; Shav-Tal, Yaron; Neugebauer, Karla M.

    2013-01-01

    The nuclear cap-binding complex (CBC) binds to the 7-methyl guanosine cap present on every RNA polymerase II transcript. CBC has been implicated in many aspects of RNA biogenesis; in addition to roles in miRNA biogenesis, nonsense-mediated decay, 3′-end formation, and snRNA export from the nucleus, CBC promotes pre-mRNA splicing. An unresolved question is how CBC participates in splicing. To investigate CBC’s role in splicing, we used mass spectrometry to identify proteins that copurify with mammalian CBC. Numerous components of spliceosomal snRNPs were specifically detected. Among these, three U4/U6·U5 snRNP proteins (hBrr2, hPrp4, and hPrp31) copurified with CBC in an RNA-independent fashion, suggesting that a significant fraction of CBC forms a complex with the U4/U6·U5 snRNP and that the activity of CBC might be associated with snRNP recruitment to pre-mRNA. To test this possibility, CBC was depleted from HeLa cells by RNAi. Chromatin immunoprecipitation and live-cell imaging assays revealed decreased cotranscriptional accumulation of U4/U6·U5 snRNPs on active transcription units, consistent with a requirement for CBC in cotranscriptional spliceosome assembly. Surprisingly, recruitment of U1 and U2 snRNPs was also affected, indicating that RNA-mediated interactions between CBC and snRNPs contribute to splicing. On the other hand, CBC depletion did not impair snRNP biogenesis, ruling out the possibility that decreased snRNP recruitment was due to changes in nuclear snRNP concentration. Taken together, the data support a model whereby CBC promotes pre-mRNA splicing through a network of interactions with and among spliceosomal snRNPs during cotranscriptional spliceosome assembly. PMID:23793891

  18. Variability in clinical phenotypes of PRPF8-linked autosomal dominant retinitis pigmentosa correlates with differential PRPF8/SNRNP200 interactions.

    Science.gov (United States)

    Escher, Pascal; Passarin, Olga; Munier, Francis L; Tran, Viet H; Vaclavik, Veronika

    2018-01-01

    To expand the genotype/phenotype correlations in patients with autosomal dominant retinitis pigmentosa (adRP) harboring PRPF8 variants. Two patients, a father and his daughter, harboring a novel p.PRPF8-Glu2331* variant, underwent ophthalmic examination at 3-year-interval, including fundus photography, fundus autofluorescence, optical coherence tomography, and ISCEV standard full field ERGs. All reported disease-causing PRPF8 variants were collected and localized in the PRPF8 and PRPF8/SNRNP200 protein structures. The p.PRPF8-Glu2331* variant results in a truncated PRPF8 protein lacking the last five C-terminal amino acids and caused in the two patients a severe clinical phenotype, with the macula being affected from the second decade on. All but two adRP-linked variants are located in the last exon 43 encoding the C-terminal tail of the C-terminal PRPF8 Jab1 domain. The p.PRPF8-Ser2118Phe and -Asn2280Lys variants encoded by exons 39 and 42, respectively, are located at the basis of the C-terminal tail. Frame-shift mutations and nonconservative amino acid changes in PRPF8 typically cause severe clinical phenotypes. The conservative missense variant p.PRPF8-Arg2310Lys that is not altering the global charge of the C-terminal tail, and variants located at the basis of the C-terminal tail show milder clinical phenotypes, in accordance with functional data on PRPF8/SNRNP200 interactions in yeast.

  19. Uranium dioxides and debris fragments released to the environment with cesium-rich microparticles from the Fukushima Daiichi Nuclear Power Plant.

    Science.gov (United States)

    Ochiai, Asumi; Imoto, Junpei; Suetake, Mizuki; Komiya, Tatsuki; Furuki, Genki; Ikehara, Ryohei; Yamasaki, Shinya; Law, Gareth T W; Ohnuki, Toshihiko; Grambow, Bernd; Ewing, Rodney C; Utsunomiya, Satoshi

    2018-01-29

    Trace U was released from the Fukushima Daiichi Nuclear Power Plant (FDNPP) during the meltdowns, but the speciation of the released components of the nuclear fuel remains unknown. We report, for the first time, the atomic-scale characteristics of nano-fragments of the nuclear fuels that were released from the FDNPP into the environment. Nano-fragments of an intrinsic U-phase were discovered to be closely associated with radioactive cesium-rich microparticles (CsMPs) in paddy soils collected ~4 km from the FDNPP. The nano-scale fuel fragments were either encapsulated by or attached to the CsMPs and occurred in two different forms: (i) UO2+X nanocrystals of ~70 nm size, which are embedded into magnetite associated with Tc and Mo on the surface. (ii) Isometric (U,Zr)O2+X nanocrystals of ~200 nm size, with the U/(U+Zr) molar ratio ranging from 0.14 to 0.91, with intrinsic pores (~6 nm), indicating the entrapment of vapors or fission-product gasses during crystallization. These results document the heterogeneous physical and chemical properties of debris at the nanoscale, which is a mixture of melted fuel and reactor materials, reflecting the complex thermal processes within the FDNPP reactor during meltdown. Still the CsMPs are an important medium for the transport of debris fragments into the environment in a respirable form.

  20. Arginine-rich cross-linking peptides with different SV40 nuclear localization signal content as vectors for intranuclear DNA delivery.

    Science.gov (United States)

    Bogacheva, Mariia; Egorova, Anna; Slita, Anna; Maretina, Marianna; Baranov, Vladislav; Kiselev, Anton

    2017-11-01

    The major barriers for intracellular DNA transportation by cationic polymers are their toxicity, poor endosomal escape and inefficient nuclear uptake. Therefore, we designed novel modular peptide-based carriers modified with SV40 nuclear localization signal (NLS). Core peptide consists of arginine, histidine and cysteine residues for DNA condensation, endosomal escape promotion and interpeptide cross-linking, respectively. We investigated three polyplexes with different NLS content (10 mol%, 50 mol% and 90 mol% of SV40 NLS) as vectors for intranuclear DNA delivery. All carriers tested were able to condense DNA, to protect it from DNAase I and were not toxic to the cells. We observed that cell cycle arrest by hydroxyurea did not affect transfection efficacy of NLS-modified carriers which we confirmed using quantitative confocal microscopy analysis. Overall, peptide carrier modified with 90 mol% of SV40 NLS provided efficient transfection and nuclear uptake in non-dividing cells. Thus, incorporation of NLS into arginine-rich cross-linking peptides is an adequate approach to the development of efficient intranuclear gene delivery vehicles. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. New approach to the nuclear in beam {gamma} spectroscopy of neutron rich nuclei at N=20 using projectile fragmentation

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Jimenez, M.J.; Saint-Laurent, M.G.; Achouri, L.; Daugas, J.M. [Grand Accelerateur National d`Ions Lourds, 14 - Caen (France); Belleguic, M.; Azaiez, F.; Bourgeois, C. [Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire; Stanoiu, M.; Borcea, C. [Institute of Atomic Physics, Bucharest (Romania); Angelique, J.C. [Caen Univ., 14 (France). Lab. de Physique Corpusculaire] [and others

    1999-11-01

    The structure of nuclei far from stability around {sup 32}Mg have been recently investigated by means of a novel method. In-beam {gamma}-decay spectroscopy of a large number of exotic neutron-rich nuclei produced by projectile fragmentation of a {sup 36}S projectile has been performed, using coincidences between the recoil fragments collected at the focal plane of SPEG spectrometer and {gamma}-rays emitted at the target location. Preliminary results on both the population mechanism and the decay of excited states in nuclei around {sup 32}Mg are presented. (author) 24 refs.

  2. Structure and properties of rare earth-rich glassed for nuclear waste immobilisation; Etude des caracteristiques structurales et des proprietes de verres riches en terres rares destines au confinement des produits de fission et elements a vie longue

    Energy Technology Data Exchange (ETDEWEB)

    Bardez, I

    2004-11-15

    A new nuclear glass composition, able to immobilize highly radioactive liquid wastes from high burn-up UO{sub 2} fuel, was established and its structure studied. The composition of the selected rare earth-rich glass is (molar %): 61.79 SiO{sub 2} - 8.94 B{sub 2}O{sub 3} - 3.05 Al{sub 2}O{sub 3} - 14.41 Na{sub 2}O - 6.32 CaO - 1.89 ZrO{sub 2} - 3.60 RE{sub 2}O{sub 3} (with RE = La, Ce, Pr and Nd). The aim of this study was to determine the local environment of the rare earth in this glass and also to glean information about the effect of glass composition on the rare earth neighbouring (influence of Si, B, Al, Na and Ca contents). To this end, several series of glasses, prepared from the baseline glass, were studied by different characterisation methods such as EXAFS spectroscopy at the neodymium LIII-edge, optical absorption spectroscopy, Raman spectroscopy and {sup 29}Si, {sup 27}Al and {sup 11}B MAS-NMR. By coupling all the results obtained, several hypotheses about the nature of the rare earth neighbouring in the glass were proposed. (author)

  3. Very low energy protons from β-delayed p-decay of proton-rich nuclei for nuclear astrophysics

    Science.gov (United States)

    Simmons, E.; Trache, L.; Banu, A.; Hardy, J. C.; Iacob, V. E.; McCleskey, M.; Roeder, B.; Spiridon, A.; Tribble, R. E.; Davinson, T.; Lotay, G.; Woods, P. J.; Saastamoinen, A.; Aysto, J.

    2009-10-01

    We developed a technique to measure very low energy protons from the beta-delayed proton-decay of proton-rich nuclei produced and separated with the MARS recoil separator at TAMU. A simple setup consisting of a telescope made of a thin double sided Si strip detector (p-detector) backed or sandwiched between two thick Si detectors (β-detectors) was designed. The source nuclei are slowed down from 30-40 MeV/u and implanted in the middle of the thin p-detector. The excited states populated in daughter nucleus above the proton threshold are resonances in the radiative proton capture leading to that nucleus; therefore, beta-decay can be a useful mechanism to study these resonances. In particular, we have studied ^23Al and ^31Cl and got information on the resonances of ^22Na(p,γ)^23Mg and ^30P(p,γ)^31S reactions, both important in novae. We studied different W1 and BB2 p-detectors, 45-140 μm thick, made by MSL, and found that thinner detectors with a small cell size are best to measure proton energies as low as 2-300 keV.

  4. On the dynamics of supermassive black holes in gas-rich, star-forming galaxies: the case for nuclear star cluster co-evolution

    Science.gov (United States)

    Biernacki, Pawel; Teyssier, Romain; Bleuler, Andreas

    2017-07-01

    We introduce a new model for the formation and evolution of supermassive black holes (SMBHs) in the ramses code using sink particles, improving over previous work the treatment of gas accretion and dynamical evolution. This new model is tested against a suite of high-resolution simulations of an isolated, gas-rich, cooling halo. We study the effect of various feedback models on the SMBH growth and its dynamics within the galaxy. In runs without any feedback, the SMBH is trapped within a massive bulge and is therefore able to grow quickly, but only if the seed mass is chosen larger than the minimum Jeans mass resolved by the simulation. We demonstrate that, in the absence of supernovae (SN) feedback, the maximum SMBH mass is reached when active galactic nucleus (AGN) heating balances gas cooling in the nuclear region. When our efficient SN feedback is included, it completely prevents bulge formation, so that massive gas clumps can perturb the SMBH orbit, and reduce the accretion rate significantly. To overcome this issue, we propose an observationally motivated model for the joint evolution of the SMBH and a parent nuclear star cluster (NSC), which allows the SMBH to remain in the nuclear region, grow fast and resist external perturbations. In this scenario, however, SN feedback controls the gas supply and the maximum SMBH mass now depends on the balance between AGN heating and gravity. We conclude that SMBH/NSC co-evolution is crucial for the growth of SMBH in high-z galaxies, the progenitors of massive ellipticals today.

  5. Lupus autoantibodies to native DNA cross-react with the A and D SnRNP polypeptides.

    Science.gov (United States)

    Reichlin, M; Martin, A; Taylor-Albert, E; Tsuzaka, K; Zhang, W; Reichlin, M W; Koren, E; Ebling, F M; Tsao, B; Hahn, B H

    1994-01-01

    Antibodies to native DNA (nDNA) in sera from patients with systemic lupus erythematosus have been found to frequently correlate with antibodies to the A and D SnRNP proteins measured in Western blot assays. 40 of 54 SLE (74.1%) sera with anti-nDNA bound to A and D proteins, while 9 of 113 sera (8%) without anti-nDNA bound the A and D proteins, P reacted equally with A and D, and two reacted predominantly with D. Two of three murine monoclonal anti-DNA antibodies isolated from NZB/NZW F1 hybrid mice bound A and D equally in Western blot with a titer > 1/40,000. These reactions were directed to the unfolded A and D proteins measurable in Western blot since these monoclonals (and several of the human anti-nDNA populations) failed to react with native U1RNP in ELISA or in RNA immunoprecipitation experiments. These newly recognized cross reactions of anti-nDNA may amplify the immune response to DNA and be part of the original immunogenic drive.

  6. C-reactive protein reacts with the U1 small nuclear ribonucleoprotein

    Energy Technology Data Exchange (ETDEWEB)

    Du Clos, T.W. (VA Medical Center, Albuquerque, NM (USA))

    1989-10-15

    C-reactive protein (CRP) was found to produce a small, discrete, speckled fluorescence pattern in the nucleus of HEp-2 cells. Double staining with anti-RNP serum and CRP produced very similar staining patterns. By counterimmunoelectrophoresis CRP was bound to extractable nuclear antigens found in rabbit thymus extract. The reactive components of the extract were only partially sensitive to treatment with RNase. CRP immunoprecipitated the U1 RNA species from ({sup 32}P)labeled HeLa cells and the protein bands of the Sm/RNP complex from ({sup 35}S)-methionine-labeled HeLa cells. By blotting, CRP bound to several discrete bands in a calcium-dependent, PC-inhibitable manner. Two of the bands comigrated with the 70K protein band associated with the U1 snRNP, and its major breakdown product. Binding to these bands was inhibited by both EDTA and PC indicating that CRP binds these proteins through the PC-binding site. Binding to the 70K protein of the U1 snRNP was confirmed by reactivity with the recombinant 70K protein in a dot blot. These findings indicate the CRP binds to the U1-RNP snRNP particle. Considering the ability of CRP to inhibit antibody responses to its ligands and its ability to activate C and promote phagocytosis it is suggested that CRP may play a role in the regulation of autoantibody responses to nuclear Ag.

  7. Murine and human antibodies to native DNA that cross-react with the A and D SnRNP polypeptides cause direct injury of cultured kidney cells.

    Science.gov (United States)

    Koren, E; Koscec, M; Wolfson-Reichlin, M; Ebling, F M; Tsao, B; Hahn, B H; Reichlin, M

    1995-05-01

    Murine monoclonal and human affinity-purified Abs to native DNA (anti-nDNA) that cross-react with the A and D SnRNP polypeptides were analyzed for direct injurious effects against cultured pig kidney (PK15) cells under ordinary cell-culture conditions. Of the two murine nephritogenic Abs derived from NZB/NZW F1 mice (BWds1 and BWds3), BWds1 initially bound to the cell surface and subsequently penetrated into cells localizing in nuclei and cytoplasm. BWds3 was consistently and abundantly associated with the surface of live cells without penetration. In the presence of rabbit C, BWds3 caused massive cell lysis (85% dead cells) whereas BWds1 had only a modest lytic effect (24% dead cells). One of the nonpathogenic murine anti-nDNA Abs (5GD5) that did not cross-react with the A and D polypeptides showed no interaction with PK-15 cells and had no injurious effects. Affinity-purified autoantibodies to nDNA isolated from two SLE patients with high anti-nDNA titers and clinically active lupus nephritis showed properties similar to the murine mAbs. They both strongly cross-reacted with the A and D SnRNP polypeptides and interacted with live PK-15 cells. One of them (Cr) penetrated into live cells and localized within cytoplasm and nuclei whereas the other (Pe) bound mostly to the cell surface and caused significant cell lysis in the presence of C. Results of this study suggest that the nephritogenic murine anti-nDNA as well as subpopulations of human anti-nDNA Abs could exert their injurious influence through direct interactions with kidney cells using two different pathogenic mechanisms (i.e., C-mediated cytotoxicity and potential cell cycle dysfunctions. Interestingly, cross-reactivity of anti-nDNA Abs with the A and D SnRNP polypeptides appears to be a prerequisite for their direct pathogenicity.

  8. Human U4/U6 snRNP recycling factor p110: Mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling

    OpenAIRE

    Medenbach, J.; Schreiner, S.; Liu, S.; Luehrmann, R.; Bindereif, A

    2004-01-01

    After each spliceosome cycle, the U4 and U6 snRNAs are released separately and are recycled to the functional U4/U6 snRNP, requiring in the mammalian system the U6-specific RNA binding protein p110 (SART3). Its domain structure is made up of an extensive N-terminal domain with at least seven tetratricopeptide repeat (TPR) motifs, followed by two RNA recognition motifs (RRMs) and a highly conserved C-terminal sequence of 10 amino acids. Here we demonstrate under in vitro recycling conditions t...

  9. Structure-function analysis and genetic interactions of the Yhc1, SmD3, SmB, and Snp1 subunits of yeast U1 snRNP and genetic interactions of SmD3 with U2 snRNP subunit Lea1.

    Science.gov (United States)

    Schwer, Beate; Shuman, Stewart

    2015-06-01

    Yhc1 and U1-C are essential subunits of the yeast and human U1 snRNP, respectively, that stabilize the duplex formed by U1 snRNA at the pre-mRNA 5' splice site (5'SS). Mutational analysis of Yhc1, guided by the human U1 snRNP crystal structure, highlighted the importance of Val20 and Ser19 at the RNA interface. Though benign on its own, V20A was lethal in the absence of branchpoint-binding complex subunit Mud2 and caused a severe growth defect in the absence of U1 subunit Nam8. S19A caused a severe defect with mud2▵. Essential DEAD-box ATPase Prp28 was bypassed by mutations of Yhc1 Val20 and Ser19, consistent with destabilization of U1•5'SS interaction. We extended the genetic analysis to SmD3, which interacts with U1-C/Yhc1 in U1 snRNP, and to SmB, its neighbor in the Sm ring. Whereas mutations of the interface of SmD3, SmB, and U1-C/Yhc1 with U1-70K/Snp1, or deletion of the interacting Snp1 N-terminal peptide, had no growth effect, they elicited synthetic defects in the absence of U1 subunit Mud1. Mutagenesis of the RNA-binding triad of SmD3 (Ser-Asn-Arg) and SmB (His-Asn-Arg) provided insights to built-in redundancies of the Sm ring, whereby no individual side-chain was essential, but simultaneous mutations of Asn or Arg residues in SmD3 and SmB were lethal. Asn-to-Ala mutations SmB and SmD3 caused synthetic defects in the absence of Mud1 or Mud2. All three RNA site mutations of SmD3 were lethal in cells lacking the U2 snRNP subunit Lea1. Benign C-terminal truncations of SmD3 were dead in the absence of Mud2 or Lea1 and barely viable in the absence of Nam8 or Mud1. In contrast, SMD3-E35A uniquely suppressed the temperature-sensitivity of lea1▵. © 2015 Schwer and Shuman; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  10. The regulatory element 3' to the A gamma-globin gene binds to the nuclear matrix and interacts with special A-T-rich binding protein 1 (SATB1), an SAR/MAR-associating region DNA binding protein.

    Science.gov (United States)

    Cunningham, J M; Purucker, M E; Jane, S M; Safer, B; Vanin, E F; Ney, P A; Lowrey, C H; Nienhuis, A W

    1994-08-15

    A cis-acting DNA regulatory element 3' to the A gamma-globin gene contains eight distinct regions of DNA-protein interaction distributed over 750 bp of DNA. The sequences of two foot-printed regions (sites I and IV) are A-T rich and generate a highly retarded complex on gel shift analysis with nuclear extract from human erythroleukemia (K562) cells. We have purified a 98-kD protein that reproduces this gel shift. Tryptic cleavage and peptide sequence analysis demonstrated that the 98-kD protein is identical to a recently cloned protein, special A-T-rich binding protein 1 (SATB1), that binds selectively to nuclear matrix/scaffold-associated regions of DNA (MARs/SARs). We have shown by functional analysis that the 3' A gamma regulatory element associates with the nuclear matrix. SATB1 mRNA was identified in K562 cells, and reverse transcriptase-polymerase chain reaction (RT-PCR) demonstrated its transcript in several other hematopoietic lines. Antisera to SATB1 caused ablation of the gel shift complex generated by both the crude nuclear extract and the purified 98-kD protein with the site I oligonucleotide. Furthermore, oligonucleotides that bind SATB1 inhibited formation of the site I gel shift complex when added as excess unlabeled competitor. An immunoblot analysis of the site I gel shift complex documented the presence of SATB1. Binding of SATB1 to two sites within the 3' A gamma regulatory element and its MAR/SAR activity suggests that this element may influence gene expression through interaction with the nuclear matrix.

  11. Evidence for a change in the nuclear mass surface with the discovery of the most neutron-rich nuclei with 17

    CERN Document Server

    Tarasov, O B; Amthor, A M; Baumann, T; Bazin, D; Gade, A; Ginter, T N; Hausmann, M; Inabe, N; Kubo, T; Nettleton, A; Pereira, J; Portillo, M; Sherrill, B M; Stolz, A; Thoennessen, M

    2009-01-01

    The results of measurements of the production of neutron-rich nuclei by the fragmentation of a 76-Ge beam are presented. The cross sections were measured for a large range of nuclei including fifteen new isotopes that are the most neutron-rich nuclides of the elements chlorine to manganese (50-Cl, 53-Ar, 55,56-K, 57,58-Ca, 59,60,61-Sc, 62,63-Ti, 65,66-V, 68-Cr, 70-Mn). The enhanced cross sections of several new nuclei relative to a simple thermal evaporation framework, previously shown to describe similar production cross sections, indicates that nuclei in the region around 62-Ti might be more stable than predicted by current mass models and could be an indication of a new island of inversion similar to that centered on 31-Na.

  12. Nepheline crystallization in boron-rich alumino-silicate glasses as investigated by multi-nuclear NMR, Raman, & Mössbauer spectroscopies

    Energy Technology Data Exchange (ETDEWEB)

    Mccloy, John S.; Washton, Nancy M.; Gassman, Paul L.; Marcial, Jose; Weaver, Jamie L.; Kukkadapu, Ravi K.

    2015-02-01

    A spectroscopic study was conducted on 6 complex simulant nuclear waste glasses using multi-nuclear NMR, Raman and Mössbauer spectroscopies to explore the role of glass-forming elements Si, Al, B, along with Na and Fe and to understand their connectivity with the goal of understanding melt structure precursors to deleterious feldspathoid nepheline-like crystals formation. NMR showed the appearance of two sites for Al, Si, and Na in the samples which crystallized significant amounts of nepheline, and B speciation changed, typically resulting in more B(IV) after nepheline crystallization. Raman spectroscopy suggested a major part of the glass structure is composed of metaborate chains or rings, thus significant numbers of non-bridging oxygens and a separation of the borate from the alumino-silicate network. Mössbauer combined with Fe redox chemical measurements showed that Fe plays a minor role in these glasses, mostly as Fe3+, but that iron oxide spinel forms with nepheline in all cases. Models of the glass network, speciation of B, and allocation of non-bridging oxygens were computed. The Yun-Dell-Bray model failed to predict the observed high concentration of NBO necessary to explain the metaborate features in the Raman spectra, and it largely over-estimated B(IV) fraction. The model assuming Na-Al-Si moieties and using experimental B(IV) fraction predicted a large amount of NBO consistent with Raman spectra. An alternative notation for appreciating the glass network is suggested and then used to investigate the changes the glass due to crystallization of sodium nepheline and the residual glass network. From a theoretical standpoint, it may be preferred to picture nuclear waste glasses by the Lebedev theory of glass structure where “microcrystallites” of ordered nuclei (or embryos) exist in the matrix of more disordered glass.

  13. Nuclear spectroscopy of very proton rich nuclei through HI induced reactions; the 14s high spin isomer in /sup 95/Pd

    CERN Document Server

    Nolte, E; Geier, R; Gui, S Z; Heim, U; Hick, H; Komninos, P; Korschinek, G; Kubik, P; Morinaga, H; Schollmeier, W

    1981-01-01

    /sup 40/Ca, /sup 58/Ni and /sup 60/Ni beams from the Munich tandem and the Munich heavy ion postaccelerator have been used to produce very proton rich nuclei in the N=50 N=82 regions. The residual nuclei have been studied with the help of gamma and particle spectroscopy. The level schemes of /sup 95/Rh, /sup 146/Dy and /sup 150/Er and the beta -decay schemes, /sup 95/Pd/sup m/ to /sup 95/Rh, /sup 144/Tb to /sup 144/Gd, /sup 146/Ho to /sup 146/Dy to /sup 146/Tb to /sup 146/Gd, /sup 148/Er to /sup 148/Ho to /sup 148/Dy and /sup 150/Tm to /sup 150/Er to /sup 150/Dy have been investigated. beta delayed proton emission from a J/sup pi / approximately=21/sup +/ isomeric state in /sup 95/Pd has been observed. (12 refs).

  14. Single Phase Melt Processed Powellite (Ba,Ca) MoO{sub 4} For The Immobilization Of Mo-Rich Nuclear Waste

    Energy Technology Data Exchange (ETDEWEB)

    Brinkman, Kyle [Savannah River Site (SRS), Aiken, SC (United States); Marra, James [Savannah River Site (SRS), Aiken, SC (United States); Fox, Kevin [Savannah River Site (SRS), Aiken, SC (United States); Reppert, Jason [Savannah River Site (SRS), Aiken, SC (United States); Crum, Jarrod [Paci fic Northwest National Laboratory , Richland, WA (United States); Tang, Ming [Los Alamos National Laboratory , Los Alamos, NM (United States)

    2012-09-17

    Crystalline and glass composite materials are currently being investigated for the immobilization of combined High Level Waste (HLW) streams resulting from potential commercial fuel reprocessing scenarios. Several of these potential waste streams contain elevated levels of transition metal elements such as molybdenum (Mo). Molybdenum has limited solubility in typical silicate glasses used for nuclear waste immobilization. Under certain chemical and controlled cooling conditions, a powellite (Ba,Ca)MoO{sub 4} crystalline structure can be formed by reaction with alkaline earth elements. In this study, single phase BaMoO{sub 4} and CaMoO{sub 4} were formed from carbonate and oxide precursors demonstrating the viability of Mo incorporation into glass, crystalline or glass composite materials by a melt and crystallization process. X-ray diffraction, photoluminescence, and Raman spectroscopy indicated a long range ordered crystalline structure. In-situ electron irradiation studies indicated that both CaMoO{sub 4} and BaMoO{sub 4} powellite phases exhibit radiation stability up to 1000 years at anticipated doses with a crystalline to amorphous transition observed after 1 X 10{sup 13} Gy. Aqueous durability determined from product consistency tests (PCT) showed low normalized release rates for Ba, Ca, and Mo (<0.05 g/m{sup 2}).

  15. An antifungal peptide from Coffea canephora seeds with sequence homology to glycine-rich proteins exerts membrane permeabilization and nuclear localization in fungi.

    Science.gov (United States)

    Zottich, Umberto; Da Cunha, Maura; Carvalho, André O; Dias, Germana B; Casarin, Nádia; Vasconcelos, Ilka M; Gomes, Valdirene M

    2013-06-01

    The superfamily of glycine-rich proteins (GRPs) corresponds to a large and complex group of plant proteins that may be involved in many developmental and physiological processes such as RNA biogenesis, stress tolerance, pollen hydration and plant-pathogen interactions, showing defensive activity against fungi, bacteria and viruses. In this study, the peptides from Coffea canephora seeds were extracted according to the methods of Egorov et al. (2005). The purified peptide was submitted for amino acid sequencing and antimicrobial activity measurement. The purified peptide with a molecular weight of 7kDa, named Cc-GRP, was observed to display homology to GRPs. The Cc-GRP-fungi interaction led to morphological changes and membrane permeability, including the formation of pseudohyphae, which were visualized with the aid of SYTOX green dye. Additionally, Cc-GRP also prevented colony formation by yeasts. Antifungal assays of Fusarium oxysporum and Colletotrichum lindemuthianum, observed by light microscopy, showed that the two molds exhibited morphological changes after the growth assay. Cc-GRP coupled to FITC and its subsequent treatment with DAPI revealed the presence of the peptide in the cell wall, cell surface and nucleus of F. oxysporum. In this work we purified, characterized and evaluated the in vitro effect on fungi of a new peptide from coffee, named Cc-GRP, which is involved in the plant defense system against pathogens by acting through a membrane permeabilization mechanism and localized in the nuclei of fungal cells. We also showed, for the first time, the intracellular localization of Cc-GRP during antimicrobial assay. Copyright © 2013 Elsevier B.V. All rights reserved.

  16. Nuclear speckles are involved in nuclear aggregation of PABPN1 and in the pathophysiology of oculopharyngeal muscular dystrophy.

    Science.gov (United States)

    Bengoechea, Rocío; Tapia, Olga; Casafont, Iñigo; Berciano, José; Lafarga, Miguel; Berciano, María T

    2012-04-01

    Nuclear speckles are essential nuclear compartments involved in the assembly, delivery and recycling of pre-mRNA processing factors, and in the post-transcriptional processing of pre-mRNAs. Oculopharyngeal muscular dystrophy (OPMD) is caused by a small expansion of the polyalanine tract in the poly(A)-binding protein nuclear 1 (PABPN1). Aggregation of expanded PABPN1 into intranuclear inclusions (INIs) in skeletal muscle fibers is the pathological hallmark of OPMD. In this study what we have analyzed in muscle fibers of OPMD patients and in primary cultures of human myoblasts are the relationships between nuclear speckles and INIs, and the contribution of the former to the biogenesis of the latter. While nuclear speckles concentrate snRNP splicing factors and PABPN1 in control muscle fibers, they are depleted of PABPN1 and appear closely associated with INIs in muscle fibers of OPMD patients. The induction of INI formation in human myoblasts expressing either wild type GFP-PABPN1 or expanded GFP-PABPN1-17ala demonstrates that the initial aggregation of PABPN1 proteins and their subsequent growth in INIs occurs at the edges of the nuclear speckles. Moreover, the growing of INIs gradually depletes PABPN1 proteins and poly(A) RNA from nuclear speckles, although the existence of these nuclear compartments is preserved. Time-lapse experiments in cultured myoblasts confirm nuclear speckles as biogenesis sites of PABPN1 inclusions. Given the functional importance of nuclear speckles in the post-transcriptional processing of pre-mRNAs, the INI-dependent molecular reorganization of these nuclear compartments in muscle fibers may cause a severe dysfunction in nuclear trafficking and processing of polyadenylated mRNAs, thereby contributing to the molecular pathophysiology of OPMD. Our results emphasize the potential importance of nuclear speckles as nuclear targets of neuromuscular disorders. Copyright © 2012 Elsevier Inc. All rights reserved.

  17. Beta decay and magnetic moments as tools to probe nuclear structure. Study of neutron-rich nuclei around N=40; Decroissance beta et moments magnetiques comme outils pour sonder la structure nucleaire. Etude des noyaux riches en neutrons autour de N=40

    Energy Technology Data Exchange (ETDEWEB)

    Matea, I

    2003-12-01

    The evolution of nuclear structure in nuclei far from the {beta} stability line is one of the 'hot topics' in modern experimental and theoretical nuclear physics. The present thesis is devoted to the study of structure of neutron-rich nuclei around N=40. The evolution of the neutron g9/2 orbital with increasing number of neutrons is one of the key points defining the structure of these nuclei at low excitation energy. We used for this investigation as experimental tools the magnetic dipole moments measurements and the {beta} decay spectroscopy. For the measurement of the gyromagnetic factor of the 9/2{sup +} isomeric state in Fe{sup 61} we have applied the TDPAD method. This method (like most of measurements of nuclear moments) requires an oriented ensemble of nuclei. The orientation of Fe{sup 61m} was achieved via the fragmentation of Ni{sup 64} at 55 MeV/u and the selection of the fragment momentum with the LISE spectrometer at GANIL. The experimental device was specially conceived to preserve the alignment up to the implantation point. The measured value of the g factor was compared with large-scale shell model and Hartree-Fock-Bogoliubov model predictions. The nuclei studied via {beta} decay were produced by the fragmentation of Kr{sup 86} at 58 MeV/u. For the selection of reaction products we used for the first time the LISE2000 spectrometer and for the detection of {gamma} rays four EXOGAM clover detectors. We measured 5 new lifetimes and 4 lifetimes with a higher precision. From the prompt {beta}{gamma} coincidences we identified new states in the daughter nuclei, as it is the case of the first 2{sup +} excited states in Fe{sup 68} and Ni{sup 72}. The results were compared with the predictions of the large-scale shell model. Other transitions were observed for the first time in {beta}{gamma} decay of Ti{sup 60}, Fe{sup 70} and Co{sup 71,73}. (author)

  18. Structure study and properties of rare earth-rich glassed for the conditioning of nuclear waste; Etude des caracteristiques structurales et des proprietes de verres riches en terres rares destines au confinement des produits de fission et elements a vie longue

    Energy Technology Data Exchange (ETDEWEB)

    Bardez, I

    2004-11-15

    A new nuclear glass composition, able to immobilize highly radioactive liquid wastes from high burn-up UO{sub 2} fuel, was established and its structure studied. The composition of the selected rare earth-rich glass is (molar %): 61.79 SiO{sub 2} - 8.94 B{sub 2}O{sub 3} - 3.05 Al{sub 2}O{sub 3} - 14.41 Na{sub 2}O - 6.32 CaO - 1.89 ZrO{sub 2} - 3.60 RE{sub 2}O{sub 3} (with RE = La, Ce, Pr and Nd) The aim of this study was to determine the local environment of the rare earth in this glass and also to glean information about the effect of glass composition on the rare earth neighbouring (influence of Si, B, Al, Na and Ca contents). To this end, several series of glasses, prepared from the baseline glass, were studied by different characterisation methods such as EXAFS spectroscopy at the neodymium L{sub III}-edge, optical absorption spectroscopy, Raman spectroscopy and {sup 29}Si, {sup 27}Al and {sup 11}B MAS-NMR. By coupling all the results obtained, several hypotheses about the nature of the rare earth neighbouring in the glass were proposed. (author)

  19. Immunocytochemical study of estrogen receptor activation factor (E-RAF and the proteins that interact with nuclear estrogen receptor II (nER II in epithelial endometrial cells, in the presence and in the absence of estradiol

    Directory of Open Access Journals (Sweden)

    OM Echeverría

    2009-06-01

    Full Text Available The localization and abundance of the estrogen receptor activation factor (E-RAF and a small nuclear ribonucleoprotein (snRNP complex containing three proteins, p32, p55 and p60, which interact with the nuclear estrogen receptor II (nER II, have been studied in rat endometrial epithelial cells by means of immunofluorescence and high resolution quantitative immunocytochemistry. In the cytoplasm E-RAF is associated with the rough endoplasmic reticulum. In the nucleus it is mainly localized at the interchromatin space, and surrounding the clumps of compact or semi-condensed chromatin. Quantitative analyses show that the abundance of E-RAF in the nucleus increases after ovariectomy and decreases 3 minutes after estradiol administration. These results are in agreement with the currently available biochemical data. Double immunolocalizations demonstrate that p32, p55, p60 co-localize with other splicing-related protein. High resolution immunolocalization shows that p32, p55, p60 are associated with perichromatin fibrils (co-transcriptional splicing and with clusters of interchromatin granules (storage of splicing-related molecules. The nuclear abundance of the snRNP complex decreases with ovariectomy, increases within 3 minutes after estradiol administration and remains higher than that in ovariectomized animals for 27 minutes. These results strongly support the previous data on the role of nER-II in the regulation of mRNA transcription and its export from the nucleus to the cytoplasm.

  20. Presence of autoantibodies against HeLa small nuclear ribonucleoproteins in chagasic and non-chagasic cardiac patients

    Directory of Open Access Journals (Sweden)

    M.C. Bosetto

    2004-01-01

    Full Text Available We detected anti-human small nuclear ribonucleoprotein (snRNP autoantibodies in chagasic patients by different immunological methods using HeLa snRNPs. ELISA with Trypanosoma cruzi total lysate antigen or HeLa human U small nuclear ribonucleoproteins (UsnRNPs followed by incubation with sera from chronic chagasic and non-chagasic cardiac patients was used to screen and compare serum reactivity. Western blot analysis using a T. cruzi total cell extract was also performed in order to select some sera for Western blot and immunoprecipitation assays with HeLa nuclear extract. ELISA showed that 73 and 95% of chronic chagasic sera reacted with HeLa UsnRNPs and T. cruzi antigens, respectively. The Western blot assay demonstrated that non-chagasic cardiac sera reacted with high molecular weight proteins present in T. cruzi total extract, probably explaining the 31% reactivity found by ELISA. However, these sera reacted weakly with HeLa UsnRNPs, in contrast to the chagasic sera, which showed autoantibodies with human Sm (from Stefanie Smith, the first patient in whom this activity was identified proteins (B/B', D1, D2, D3, E, F, and G UsnRNP. Immunoprecipitation reactions using HeLa nuclear extracts confirmed the reactivity of chagasic sera and human UsnRNA/RNPs, while the other sera reacted weakly only with U1snRNP. These findings agree with previously reported data, thus supporting the idea of the presence of autoimmune antibodies in chagasic patients. Interestingly, non-chagasic cardiac sera also showed reactivity with T. cruzi antigen and HeLa UsnRNPs, which suggests that individuals with heart disease of unknown etiology may develop autoimmune antibodies at any time. The detection of UsnRNP autoantibodies in chagasic patients might contribute to our understanding of how they develop upon initial T. cruzi infection.

  1. Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core

    Energy Technology Data Exchange (ETDEWEB)

    Montemayor, Eric J.; Didychuk, Allison L.; Liao, Honghong; Hu, Panzhou; Brow, David A.; Butcher, Samuel E. (UW)

    2017-01-01

    U6 small nuclear RNA (snRNA) is a key component of the active site of the spliceosome, a large ribonucleoprotein complex that catalyzes the splicing of precursor messenger RNA. Prior to its incorporation into the spliceosome, U6 is bound by the protein Prp24, which facilitates unwinding of the U6 internal stem-loop (ISL) so that it can pair with U4 snRNA. A previously reported crystal structure of the `core' of the U6 small nuclear ribonucleoprotein (snRNP) contained an ISL-stabilized A62G mutant of U6 bound to all four RNA-recognition motif (RRM) domains of Prp24 [Montemayoret al.(2014),Nature Struct. Mol. Biol.21, 544–551]. The structure revealed a novel topology containing interlocked rings of protein and RNA that was not predicted by prior biochemical and genetic data. Here, the crystal structure of the U6 snRNP core with a wild-type ISL is reported. This complex crystallized in a new space group, apparently owing in part to the presence of an intramolecular cross-link in RRM1 that was not observed in the previously reported U6-A62G structure. The structure exhibits the same protein–RNA interface and maintains the unique interlocked topology. However, the orientation of the wild-type ISL is altered relative to the A62G mutant structure, suggesting inherent structural dynamics that may facilitate its pairing with U4. Consistent with their similar architectures in the crystalline state, the wild-type and A62G variants of U6 exhibit similar Prp24-binding affinities and electrophoretic mobilities when analyzed by gel-shift assay.

  2. Nuclear Medicine

    Science.gov (United States)

    ... Parents/Teachers Resource Links for Students Glossary Nuclear Medicine What is nuclear medicine? What are radioactive tracers? ... funded researchers advancing nuclear medicine? What is nuclear medicine? Nuclear medicine is a medical specialty that uses ...

  3. SMN Is Essential for the Biogenesis of U7 Small Nuclear Ribonucleoprotein and 3′-End Formation of Histone mRNAs

    Directory of Open Access Journals (Sweden)

    Sarah Tisdale

    2013-12-01

    Full Text Available Spinal muscular atrophy (SMA is a neurodegenerative disease caused by a deficiency in the survival motor neuron (SMN protein. SMN mediates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs and possibly other RNPs. Here, we investigated SMN requirement for the biogenesis and function of U7—an snRNP specialized in the 3′-end formation of replication-dependent histone mRNAs that normally are not polyadenylated. We show that SMN deficiency impairs U7 snRNP assembly and decreases U7 levels in mammalian cells. The SMN-dependent U7 reduction affects endonucleolytic cleavage of histone mRNAs leading to abnormal accumulation of 3′-extended and polyadenylated transcripts followed by downstream changes in histone gene expression. Importantly, SMN deficiency induces defects of histone mRNA 3′-end formation in both SMA mice and human patients. These findings demonstrate that SMN is essential for U7 biogenesis and histone mRNA processing in vivo and identify an additional RNA pathway disrupted in SMA.

  4. The gene for human U2 snRNP auxiliary factor small 35-kDa subunit (U2AF1) maps to the progressive myoclonus epilepsy (EPM1) critical region on chromosome 21q22.3

    Energy Technology Data Exchange (ETDEWEB)

    Lalioti, M.D.; Rossier, C.; Antonarakis, S.E. [Univ. of Geneva Medical School (Switzerland)] [and others

    1996-04-15

    We used targeted exon trapping to clone portions of genes from human chromosome 21q22.3. One trapped sequence showed complete homology with the cDNA of human U2AF{sup 35} (M96982; HGM-approved nomenclature U2AF1), which encodes for the small 35-kDa subunit of the U2 snRNP auxiliary factor. Using the U2AF1 cDNA as a probe, we mapped this gene to cosmid Q15D2, a P1, and YAC 350F7 of the Chumakov et al. contig, close to the cystathionine-{beta}-synthase gene (CBS) on 21q22.3. This localization was confirmed by PCR using oligonucleotides from the 3{prime} UTR and by FISH. As U2AF1 associated with a number of different factors during mRNA splicing, overexpression in trisomy 21 individuals could contribute to some Down syndrome phenotypes by interfering with the splicing process. Furthermore, because this gene maps in the critical region for the progressive myoclonus epilepsy I locus (EPM1), mutation analysis will be carried out in patients to evaluate the potential role of U2AF1 as a candidate for EPM1. 24 refs., 1 fig.

  5. Rich catalytic injection

    Science.gov (United States)

    Veninger, Albert [Coventry, CT

    2008-12-30

    A gas turbine engine includes a compressor, a rich catalytic injector, a combustor, and a turbine. The rich catalytic injector includes a rich catalytic device, a mixing zone, and an injection assembly. The injection assembly provides an interface between the mixing zone and the combustor. The injection assembly can inject diffusion fuel into the combustor, provides flame aerodynamic stabilization in the combustor, and may include an ignition device.

  6. Hydrogen rich gas generator

    Science.gov (United States)

    Houseman, J. (Inventor)

    1976-01-01

    A process and apparatus is described for producing a hydrogen rich gas by introducing a liquid hydrocarbon fuel in the form of a spray into a partial oxidation region and mixing with a mixture of steam and air that is preheated by indirect heat exchange with the formed hydrogen rich gas, igniting the hydrocarbon fuel spray mixed with the preheated mixture of steam and air within the partial oxidation region to form a hydrogen rich gas.

  7. Kings Today, Rich Tomorrow

    DEFF Research Database (Denmark)

    Fattoum, Asma

    2013-01-01

    This study investigates the King vs. Rich dilemma that founder-CEOs face at IPO. When undertaking IPO, founders face two options. They can either get rich, but then run the risk of losing the control over their firms; or they can remain kings by introducing defensive mechanisms, but this is likel...

  8. Probing proton transition momentum in neutron-rich matter

    Science.gov (United States)

    Yong, Gao-Chan

    2018-01-01

    Around the nuclear Fermi momentum, there is a transition of nucleon momentum distribution n(k) in nuclear matter, i.e., from a constant to the 1 /k4 nucleon momentum distribution. While nowadays the transition momentum of minority in asymmetric matter is rarely studied and thus undetermined. In the framework of the IBUU transport model, proton transition momentum in nuclei is first studied. It is found that the transition momentum of proton is sensitive to the π- /π+ ratio as well as the energetic photon production in neutron-rich nuclear reaction. This result may push the study of how the proton momentum is distributed in neutron-rich matter forward and help us to better understand the dynamics of both neutron-rich nuclear reactions and neutron stars.

  9. Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: can effects be explained by structure?

    Science.gov (United States)

    Volman, Julia J; Helsper, Johannes P F G; Wei, Song; Baars, Johan J P; van Griensven, Leo J L D; Sonnenberg, Anton S M; Mensink, Ronald P; Plat, Jogchum

    2010-02-01

    Mushrooms are known for their immune-modulating and anti-tumour properties. The polysaccharide fraction, mainly beta-glucans, is responsible for the immune-modulating effects. Fungal beta-glucans have been shown to activate leukocytes, which depend on structural characteristics of beta-glucans. As edible mushrooms come in contact with the intestinal immune system, effects on enterocytes are also interesting. Our aim was to evaluate the effect of mushroom polysaccharide extracts varying in beta-glucan structure on nitric oxide production by bone marrow-derived macrophages (BMMs) from mice and on nuclear factor-kappaB transactivation in human intestinal Caco-2 cells. We demonstrated that extracts from Agaricus bisporus stimulated nitric oxide production by BMM, whereas extracts from Coprinus comatus and spores of Ganoderma lucidum had only minor effects. Furthermore, extracts of A. blazei Murill and Phellinus linteus had no effect at all. Almost all mushroom extracts lowered nuclear factor-kappaB transactivation in Caco-2 cells. Structural analysis of A. bisporus compared with A. blazei Murill suggests that branching of the beta-glucan chain is essential for immune-stimulating activity. In conclusion, extracts from A. bisporus activate BMM, without activating enterocytes. These characteristics make A. bisporus an attractive candidate as a nutritional compound to stimulate the immune response in depressed states of immunity.

  10. Nuclear "waffles"

    Science.gov (United States)

    Schneider, A. S.; Berry, D. K.; Briggs, C. M.; Caplan, M. E.; Horowitz, C. J.

    2014-11-01

    Background: The dense neutron-rich matter found in supernovae and inside neutron stars is expected to form complex nonuniform phases, often referred to as nuclear pasta. The pasta shapes depend on density, temperature and proton fraction and determine many transport properties in supernovae and neutron star crusts. Purpose: To characterize the topology and compute two observables, the radial distribution function (RDF) g (r ) and the structure factor S (q ) , for systems with proton fractions Yp=0.10 ,0.20 ,0.30 , and 0.40 at about one-third of nuclear saturation density, n =0.050 fm-3 , and temperatures near k T =1 MeV . Methods: We use two recently developed hybrid CPU/GPU codes to perform large scale molecular dynamics (MD) simulations with 51 200 and 409 600 nucleons. From the output of the MD simulations we obtain the two desired observables. Results: We compute and discuss the differences in topology and observables for each simulation. We observe that the two lowest proton fraction systems simulated, Yp=0.10 and 0.20 , equilibrate quickly and form liquidlike structures. Meanwhile, the two higher proton fraction systems, Yp=0.30 and 0.40 , take a longer time to equilibrate and organize themselves in solidlike periodic structures. Furthermore, the Yp=0.40 system is made up of slabs, lasagna phase, interconnected by defects while the Yp=0.30 systems consist of a stack of perforated plates, the nuclear waffle phase. Conclusions: The periodic configurations observed in our MD simulations for proton fractions Yp≥0.30 have important consequences for the structure factors S (q ) of protons and neutrons, which relate to many transport properties of supernovae and neutron star crust. A detailed study of the waffle phase and how its structure depends on temperature, size of the simulation, and the screening length showed that finite-size effects appear to be under control and, also, that the plates in the waffle phase merge at temperatures slightly above 1.0 MeV and

  11. The neutrino opacity of neutron rich matter

    Energy Technology Data Exchange (ETDEWEB)

    Alcain, P.N., E-mail: pabloalcain@gmail.com [Departamento de Física, FCEyN, UBA and IFIBA, Conicet, Pabellón 1, Ciudad Universitaria, 1428 Buenos Aires (Argentina); IFIBA-CONICET (Argentina); Dorso, C.O. [Departamento de Física, FCEyN, UBA and IFIBA, Conicet, Pabellón 1, Ciudad Universitaria, 1428 Buenos Aires (Argentina); IFIBA-CONICET (Argentina)

    2017-05-15

    The study of neutron rich matter, present in neutron star, proto-neutron stars and core-collapse supernovae, can lead to further understanding of the behavior of nuclear matter in highly asymmetric nuclei. Heterogeneous structures are expected to exist in these systems, often referred to as nuclear pasta. We have carried out a systematic study of neutrino opacity for different thermodynamic conditions in order to assess the impact that the structure has on it. We studied the dynamics of the neutrino opacity of the heterogeneous matter at different thermodynamic conditions with semiclassical molecular dynamics model already used to study nuclear multifragmentation. For different densities, proton fractions and temperature, we calculate the very long range opacity and the cluster distribution. The neutrino opacity is of crucial importance for the evolution of the core-collapse supernovae and the neutrino scattering.

  12. Rich Design Research Space

    Directory of Open Access Journals (Sweden)

    Birger Sevaldson

    2008-10-01

    Full Text Available This paper introduces and discusses a Rich Research Space as an inclusive methodological framework and scaffold for research-by-design. The Rich Research Space especially addresses the issue of richness in design processes and design-led research. There is a general trend towards increased complexity in design processes, caused on one hand by the increasing depth and width in the use of design media and methods, and on the other hand by the increasing complexity and interdependency of society due to globalisation. These issues confront the designer-researcher with new challenges. This paper formulates a research strategy for research-by-design in fields that have a high degree of richness in the use of media, the amount of information, and the methods involved. The Rich Research Space concept proposed takes into account the physical, social, and cultural spaces, and the virtual and visual media spaces in which the research-by-design takes place. The concept takes the form of a specific integral approach to design, and a holistic theoretical mindset. It embraces many types of investigation, from analytical to intuitive. The Rich Research Space provides a flexible framework within which the complexity of research-by-design can be interrelated, discussed, and reflected upon. Potentially, it can create a more involved role for the designer-researcher, a role that allows contributions towards the resolution of ever more pressing issues in our society. This approach is currently one of a limited number of possible frameworks that the design professions can utilize in order to make a difference in a world of at times overwhelming complexity. The concept of the Rich Research Space is discussed with reference to an art installation called Barely.Keywords: Research by design, collaborative design, complexity, creativity, research methods.

  13. Nuclear Factor-κB (NF-κB Regulates the Expression of Human Testis-Enriched Leucine-Rich Repeats and WD Repeat Domain Containing 1 (LRWD1 Gene

    Directory of Open Access Journals (Sweden)

    Yo-Wen Liu

    2012-12-01

    Full Text Available The human Leucine-rich Repeats and WD repeat Domain containing 1 (LRWD1 gene was originally identified by cDNA microarray as one of the genes down-regulated in the testicular tissues of patients with severe spermatogenic defects. Human LRWD1 is a testicular-enriched protein that is present predominantly in the cytoplasm of spermatocytes and spermatids and colocalizes with the centrosome at the base of sperm tail. Reporter assay, Chromatin immunoprecipitation (ChIP analysis, and gel electrophoretic mobility shift assay (EMSA were used to identify the core promoter region of LRWD1. A 198 bp segment upstream of the LRWD1 transcription initiation site exhibited promoter activity. The LRWD1 core promoter lacked a TATA box but contained a NF-κB binding site. Chromatin immunoprecipitation (ChIP analysis and gel electrophoretic mobility shift assay (EMSA showed basal binding of the NF-κB subunit to the LRWD1 promoter. LRWD1 promoter activity was positively regulated by NF-κB, and this regulation was dependent on the presence of the conserved κB site in the LRWD1 promoter region. Our data suggest that NF-κB is an important regulator for the expression of LRWD1. This is the first study showing that the expression of the testis-enriched LRWD1 gene is regulated by NF-κB.

  14. Rich Internet Applications

    OpenAIRE

    Farré López, Xavier

    2005-01-01

    El propósito principal de este proyecto es estudiar el origen y funcionamiento de las Rich Internet Applicacions (RIA), que son un nuevo tipo de aplicaciones mucho más óptimas e impactantes que las tradicionales aplicaciones Web. Para llevarlo a cabo primero se ha definido el concepto de aplicación Web y se han expuesto las limitaciones que tienen. El siguiente paso ha sido definir el concepto de Rich Internet Applications y se han listado los objetivos por los que han sido ...

  15. Nuclear reactions an introduction

    CERN Document Server

    Paetz gen. Schieck, Hans

    2014-01-01

    Nuclei and nuclear reactions offer a unique setting for investigating three (and in some cases even all four) of the fundamental forces in nature. Nuclei have been shown – mainly by performing scattering experiments with electrons, muons, and neutrinos – to be extended objects with complex internal structures: constituent quarks; gluons, whose exchange binds the quarks together; sea-quarks, the ubiquitous virtual quark-antiquark pairs and, last but not least, clouds of virtual mesons, surrounding an inner nuclear region, their exchange being the source of the nucleon-nucleon interaction.   The interplay between the (mostly attractive) hadronic nucleon-nucleon interaction and the repulsive Coulomb force is responsible for the existence of nuclei; their degree of stability, expressed in the details and limits of the chart of nuclides; their rich structure and the variety of their interactions. Despite the impressive successes of the classical nuclear models and of ab-initio approaches, there is clearly no ...

  16. Nuclear Chemistry.

    Science.gov (United States)

    Chemical and Engineering News, 1979

    1979-01-01

    Provides a brief review of the latest developments in nuclear chemistry. Nuclear research today is directed toward increased activity in radiopharmaceuticals and formation of new isotopes by high-energy, heavy-ion collisions. (Author/BB)

  17. Nuclear Scans

    Science.gov (United States)

    Nuclear scans use radioactive substances to see structures and functions inside your body. They use a special ... images. Most scans take 20 to 45 minutes. Nuclear scans can help doctors diagnose many conditions, including ...

  18. The CBM RICH project

    Energy Technology Data Exchange (ETDEWEB)

    Adamczewski-Musch, J. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Akishin, P. [Laboratory of Information Technologies, Joint Institute for Nuclear research (JINR-LIT), Dubna (Russian Federation); Becker, K.-H. [Department of Physics, University of Wuppertal, D-42097 Wuppertal (Germany); Belogurov, S. [SSC RF ITEP, 117218 Moscow (Russian Federation); Bendarouach, J. [Institute of Physics II and Institute of Applied Physics, Justus Liebig University Giessen, D-35392 Giessen (Germany); Boldyreva, N. [National Research Centre “Kurchatov Institute” B.P. Konstantinov Petersburg Nuclear Physics Institute, 188300 Gatchina (Russian Federation); Chernogorov, A. [SSC RF ITEP, 117218 Moscow (Russian Federation); Deveaux, C. [Institute of Physics II and Institute of Applied Physics, Justus Liebig University Giessen, D-35392 Giessen (Germany); Dobyrn, V. [National Research Centre “Kurchatov Institute” B.P. Konstantinov Petersburg Nuclear Physics Institute, 188300 Gatchina (Russian Federation); Dürr, M. [Institute of Physics II and Institute of Applied Physics, Justus Liebig University Giessen, D-35392 Giessen (Germany); Eschke, J. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Förtsch, J. [Department of Physics, University of Wuppertal, D-42097 Wuppertal (Germany); Heep, J.; Höhne, C. [Institute of Physics II and Institute of Applied Physics, Justus Liebig University Giessen, D-35392 Giessen (Germany); Kampert, K.-H. [Department of Physics, University of Wuppertal, D-42097 Wuppertal (Germany); and others

    2017-02-11

    The CBM RICH detector is an integral component of the future CBM experiment at FAIR, providing efficient electron identification and pion suppression necessary for the measurement of rare dileptonic probes in heavy ion collisions. The RICH design is based on CO{sub 2} gas as radiator, a segmented spherical glass focussing mirror with Al+MgF{sub 2} reflective coating, and Multianode Photomultipliers for efficient Cherenkov photon detection. Hamamatsu H12700 MAPMTs have recently been selected as photon sensors, following an extensive sensor evaluation, including irradiation tests to ensure sufficient radiation hardness of the MAPMTs. A brief overview of the detector design and concept is given, results on the radiation hardness of the photon sensors are shown, and the development of a FPGA-TDC based readout chain is discussed.

  19. Nuclear weapons, nuclear effects, nuclear war

    Energy Technology Data Exchange (ETDEWEB)

    Bing, G.F.

    1991-08-20

    This paper provides a brief and mostly non-technical description of the militarily important features of nuclear weapons, of the physical phenomena associated with individual explosions, and of the expected or possible results of the use of many weapons in a nuclear war. Most emphasis is on the effects of so-called ``strategic exchanges.``

  20. JPRS Report, Nuclear Developments

    National Research Council Canada - National Science Library

    1989-01-01

    Partial Contents: Nuclear Weapons, Nuclear Development, Nuclear Power Plant, Uranium, Missiles, Space Firm Protested, Satellite, Rocket Launching, Nuclear Submarine, Environmental, Radioactivity, Nuclear Plant...

  1. Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA.

    Directory of Open Access Journals (Sweden)

    Jens Verbeeren

    2017-05-01

    Full Text Available Cellular homeostasis of the minor spliceosome is regulated by a negative feed-back loop that targets U11-48K and U11/U12-65K mRNAs encoding essential components of the U12-type intron-specific U11/U12 di-snRNP. This involves interaction of the U11 snRNP with an evolutionarily conserved splicing enhancer giving rise to unproductive mRNA isoforms. In the case of U11/U12-65K, this mechanism controls the length of the 3' untranslated region (3'UTR. We show that this process is dynamically regulated in developing neurons and some other cell types, and involves a binary switch between translation-competent mRNAs with a short 3'UTR to non-productive isoforms with a long 3'UTR that are retained in the nucleus or/and spliced to the downstream amylase locus. Importantly, the choice between these alternatives is determined by alternative terminal exon definition events regulated by conserved U12- and U2-type 5' splice sites as well as sequence signals used for pre-mRNA cleavage and polyadenylation. We additionally show that U11 snRNP binding to the U11/U12-65K mRNA species with a long 3'UTR is required for their nuclear retention. Together, our studies uncover an intricate molecular circuitry regulating the abundance of a key spliceosomal protein and shed new light on the mechanisms limiting the export of non-productively spliced mRNAs from the nucleus to the cytoplasm.

  2. Nuclear spectroscopy

    CERN Document Server

    Ajzenberg-Selove, Fay

    1960-01-01

    Nuclear Spectroscopy, Part B focuses on the ways in which experimental data may be analyzed to furnish information about nuclear parameters and nuclear models in terms of which the data are interpreted.This book discusses the elastic and inelastic potential scattering amplitudes, role of beta decay in nuclear physics, and general selection rules for electromagnetic transitions. The nuclear shell model, fundamental coupling procedure, vibrational spectra, and empirical determination of the complex potential are also covered. This publication is suitable for graduate students preparing for exper

  3. Nuclear networking.

    Science.gov (United States)

    Xie, Wei; Burke, Brian

    2017-07-04

    Nuclear lamins are intermediate filament proteins that represent important structural components of metazoan nuclear envelopes (NEs). By combining proteomics and superresolution microscopy, we recently reported that both A- and B-type nuclear lamins form spatially distinct filament networks at the nuclear periphery of mouse fibroblasts. In particular, A-type lamins exhibit differential association with nuclear pore complexes (NPCs). Our studies reveal that the nuclear lamina network in mammalian somatic cells is less ordered and more complex than that of amphibian oocytes, the only other system in which the lamina has been visualized at high resolution. In addition, the NPC component Tpr likely links NPCs to the A-type lamin network, an association that appears to be regulated by C-terminal modification of various A-type lamin isoforms. Many questions remain, however, concerning the structure and assembly of lamin filaments, as well as with their mode of association with other nuclear components such as peripheral chromatin.

  4. Haloes and clustering in light, neutron-rich nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Orr, N.A

    2001-10-01

    Clustering is a relatively widespread phenomenon which takes on many guises across the nuclear landscape. Selected topics concerning the study of halo systems and clustering in light, neutron-rich nuclei are discussed here through illustrative examples taken from the Be isotopic chain. (author)

  5. Recent results on neutron rich tin isotopes by laser spectroscopy

    CERN Document Server

    Roussière, B; Crawford, J E; Essabaa, S; Fedosseev, V; Geithner, W; Genevey, J; Girod, M; Huber, G; Horn, R; Kappertz, S; Lassen, J; Le Blanc, F; Lee, J K P; Le Scornet, G; Lettry, Jacques; Mishin, V I; Neugart, R; Obert, J; Oms, J; Ouchrif, A; Peru, S; Pinard, J; Ravn, H L; Sauvage, J; Verney, D

    2001-01-01

    Laser spectroscopy measurements have been performed on neutron rich tin isotopes using the COMPLIS experimental setup. The nuclear charge radii of the even-even isotopes from A=108 to 132 are compared to the results of macroscopic and microscopic calculations. The improvements and optimizations needed to perform the isotope shift measurement on $^{134}$Sn are presented.

  6. Get rich blogging

    CERN Document Server

    Griffin, Zoe

    2013-01-01

    The Sunday Mirror's former showbiz gossip columnist, Zoe Griffin, explains how she quit her job and started a blog in order to work less and earn more. In this book she explains how to Get Rich Blogging and how she has done just that with her Live Like A VIP blog ? which generates a six figure income. There is no need to be a technical wizard. All you need is this book, a laptop and internet access and you too could be blogging your way to wealth and happiness. Contributors include The Clothes Whisperer, The Fashion Editor at Large, Mumsnet, Tech Week, Music News and Mr Porter ? all finan

  7. Nuclear astrophysics

    Energy Technology Data Exchange (ETDEWEB)

    Haxton, W.C.

    1992-01-01

    The problem of core-collapse supernovae is used to illustrate the many connections between nuclear astrophysics and the problems nuclear physicists study in terrestrial laboratories. Efforts to better understand the collapse and mantle ejection are also motivated by a variety of interdisciplinary issues in nuclear, particle, and astrophysics, including galactic chemical evolution, neutrino masses and mixing, and stellar cooling by the emission of new particles. The current status of theory and observations is summarized.

  8. Nuclear astrophysics

    Energy Technology Data Exchange (ETDEWEB)

    Haxton, W.C.

    1992-12-31

    The problem of core-collapse supernovae is used to illustrate the many connections between nuclear astrophysics and the problems nuclear physicists study in terrestrial laboratories. Efforts to better understand the collapse and mantle ejection are also motivated by a variety of interdisciplinary issues in nuclear, particle, and astrophysics, including galactic chemical evolution, neutrino masses and mixing, and stellar cooling by the emission of new particles. The current status of theory and observations is summarized.

  9. Nuclear Safety

    Energy Technology Data Exchange (ETDEWEB)

    Silver, E G [ed.

    1989-01-01

    This document is a review journal that covers significant developments in the field of nuclear safety. Its scope includes the analysis and control of hazards associated with nuclear energy, operations involving fissionable materials, and the products of nuclear fission and their effects on the environment. Primary emphasis is on safety in reactor design, construction, and operation; however, the safety aspects of the entire fuel cycle, including fuel fabrication, spent-fuel processing, nuclear waste disposal, handling of radioisotopes, and environmental effects of these operations, are also treated.

  10. Nuclear Astrophysics

    Science.gov (United States)

    Drago, Alessandro

    2005-04-01

    The activity of the Italian nuclear physicists community in the field of Nuclear Astrophysics is reported. The researches here described have been performed within the project "Fisica teorica del nucleo e dei sistemi a multi corpi", supported by the Ministero dell'Istruzione, dell'Università e della Ricerca.

  11. Nuclear Astrophysics

    CERN Document Server

    Langanke, K

    1999-01-01

    The manuscript reviews progress achieved in recent years in various aspects of nuclear astrophysics, including stellar nucleosynthesis, nuclear aspects of supernova collapse and explosion, neutrino-induced reactions and their possible role in the supernova mechanism and nucleosynthesis, explosive hydrogen burning in binary systems, and finally the observation of gamma-rays from supernova remnants.

  12. Nuclear stress test

    Science.gov (United States)

    ... Persantine stress test; Thallium stress test; Stress test - nuclear; Adenosine stress test; Regadenoson stress test; CAD - nuclear stress; Coronary artery disease - nuclear stress; Angina - nuclear ...

  13. Nuclear questions

    Energy Technology Data Exchange (ETDEWEB)

    Durrani, M. [Physics World (United Kingdom)

    2006-01-01

    The future of nuclear power has returned to centre stage. Freezing weather on both sides of the Atlantic and last month's climate-change talks in Montreal have helped to put energy and the future of nuclear power right back on the political agenda. The issue is particularly pressing for those countries where existing nuclear stations are reaching the end of their lives. In the UK, prime minister Tony Blair has commissioned a review of energy, with a view to deciding later this year whether to build new nuclear power plants. The review comes just four years after the Labour government published a White Paper on energy that said the country should keep the nuclear option open but did not follow this up with any concrete action. In Germany, new chancellor and former physicist Angela Merkel is a fan of nuclear energy and had said she would extend the lifetime of its nuclear plants beyond 2020, when they are due to close. However, that commitment has had to be abandoned, at least for the time being, following negotiations with her left-wing coalition partners. The arguments in favour of nuclear power will be familiar to all physicists - it emits almost no carbon dioxide and can play a vital role in maintaining a diverse energy supply. To over-rely on imported supplies of oil and gas can leave a nation hostage to fortune. The arguments against are equally easy to list - the public is scared of nuclear power, it generates dangerous waste with potentially huge clean-up costs, and it is not necessarily cheap. Nuclear plants could also be a target for terrorist attacks. Given political will, many of these problems can be resolved, or at least tackled. China certainly sees the benefits of nuclear power, as does Finland, which is building a new 1600 MW station - the world's most powerful - that is set to open in 2009. Physicists, of course, are essential to such developments. They play a vital role in ensuring the safety of such plants and developing new types of

  14. Nuclear war and nuclear peace

    Energy Technology Data Exchange (ETDEWEB)

    Segal, G.; Moreton, E.; Freedman, L.; Baylis, J.

    1983-01-01

    This book is an in-depth examination of East-West tactical and strategic nuclear weapons policy. The contributors explore such issues as the history and implications of tactical weapons in Europe, the general conflicts that have characterized US and Soviet interaction, the development of British nuclear weapons policy, and arms control including SALT I and II and the START talks.

  15. Orthobiologics and platelet rich plasma

    National Research Council Canada - National Science Library

    Dhillon, Mandeep S; Behera, Prateek; Patel, Sandeep; Shetty, Vijay

    2014-01-01

    ... in many chronic musculoskeletal ailments. Investigators have published results of laboratory as well as clinical studies, using orthobiologics like platelet rich plasma, stem cells, autologous conditioned serum etc...

  16. LHCB RICH gas system proposal

    CERN Document Server

    Bosteels, Michel; Haider, S

    2001-01-01

    Both LHCb RICH will be operated with fluorocarbon as gas radiator. RICH 1 will be filled with 4m^3 of C4F10 and RICH 2 with 100m^3 of CF4. The gas systems will run as a closed loop circulation and a gas recovery system within the closed loop is planned for RICH 1, where the recovery of the CF4 will only be realised during filling and emptying of the detector. Inline gas purification is foreseen for the gas systems in order to limit water and oxygen impurities.

  17. Nuclear Physics

    CERN Document Server

    Savage, Martin J

    2016-01-01

    Lattice QCD is making good progress toward calculating the structure and properties of light nuclei and the forces between nucleons. These calculations will ultimately refine the nuclear forces, particularly in the three- and four-nucleon sector and the short-distance interactions of nucleons with electroweak currents, and allow for a reduction of uncertainties in nuclear many-body calculations of nuclei and their reactions. After highlighting their importance, particularly to the Nuclear Physics and High-Energy Physics experimental programs, I discuss the progress that has been made toward achieving these goals and the challenges that remain.

  18. Investigations of Nuclear Structure

    Energy Technology Data Exchange (ETDEWEB)

    Sarantites, Demetrios [Washington Univ., St. Louis, MO (United States); Reviol, W. [Washington Univ., St. Louis, MO (United States)

    2015-07-15

    The proposal addresses studies of nuclear structure at low-energies and development of instrumentation for that purpose. The structure studies deal with features of neutron-rich nuclei with unexplored shapes (football- or pear-shaped nuclei). The regions of interest are: neutron rich nuclei like 132-138Sn, or 48-54Ca, and the Zr, Mo, and Ru isotopes. The tools used can be grouped as follows: either Gammasphere or Gretina multi-gamma detector arrays and auxiliary detectors (Microball, Neutron Shell, and the newly completed Phoswich Wall).The neutron-rich nuclei are accessed by radioactive-beam binary reactions or by 252Cf spontaneous fission. The experiments with heavy radioactive beams aim at exciting the beam nuclei by pick-up or transfer a neutron or a proton from a light target like 13C, 9Be, 11B or 14N .For these binary-reaction studies the Phoswich Wall detector system is essential. It is based on four multi-anode photomultiplier tubes on which CsI and thin fast-timing plastic scintillators are attached. Their signals are digitized with a high density microchip system.

  19. Information rich display design

    Energy Technology Data Exchange (ETDEWEB)

    Welch, Robin; Braseth, Alf Ove; Veland, Oeystein

    2004-07-01

    This paper presents the concept Information Rich Displays. The purpose of Information Rich Displays (IRDs) is to condensate prevailing information in process displays in such a way that each display format (picture) contains more relevant information for the user. Compared to traditional process control displays, this new concept allows the operator to attain key information at a glance and at the same time allows for improved monitoring of larger portions of the process. This again allows for reduced navigation between both process and trend displays and ease the cognitive demand on the operator. This concept has been created while working on designing display prototypes for the offshore petroleum production facilities of tomorrow. Offshore installations basically consist of wells, separation trains (where oil, gas and water are separated from each other), an oil tax measurement system (where oil quality is measured and the pressure increased to allow for export), gas compression (compression of gas for export) and utility systems (water treatment, chemical systems etc.). This means that an offshore control room operator has to deal with a complex process that comprises several functionally different systems. The need for a new approach to offshore display format design is in particular based on shortcomings in today's designs related to the keyhole effect, where the display format only reveals a fraction of the whole process. Furthermore, the upcoming introduction of larger off- and on-shore operation centres will increase the size and complexity of the operators' work domain. In the light of the increased demands on the operator, the proposed IRDs aim to counter the negative effects this may have on the workload. In this work we have attempted to classify the wide range of different roles an operator can have in different situations. The information content and amount being presented to the operator in a display should be viewed in context of the roles

  20. (Nuclear theory). [Research in nuclear physics

    Energy Technology Data Exchange (ETDEWEB)

    Haxton, W.

    1990-01-01

    This report discusses research in nuclear physics. Topics covered in this paper are: symmetry principles; nuclear astrophysics; nuclear structure; quark-gluon plasma; quantum chromodynamics; symmetry breaking; nuclear deformation; and cold fusion. (LSP)

  1. Nuclear reaction

    CERN Multimedia

    Penwarden, C

    2001-01-01

    At the European Research Organization for Nuclear Research, Nobel laureates delve into the mysteries of particle physics. But when they invited artists from across the continent to visit their site in Geneva, they wanted a new kind of experiment.

  2. Nuclear Fusion

    National Research Council Canada - National Science Library

    Ghoranneviss, Mahmood; Parashar, S. K. S; Aslan, Necdet; Aslaninejad, Morteza; Salar Elahi, A

    2014-01-01

    ... in both inertial and magnetic confinement fusion, with attendees from major fusion energy research centers worldwide. It is one of the most important issues in this field. Nuclear fusion continues t...

  3. Nuclear Structure

    Science.gov (United States)

    Gargano, Angela

    2003-04-01

    An account of recent studies in the field of theoretical nuclear structure is reported. These studies concern essentially research activities performed under the Italian project "Fisica Teorica del Nucleo e dei Sistemi a Molti Corpi". Special attention is addressed to results obtained during the last two years as regards the development of new many-body techniques as well as the interpretation of new experimental aspects of nuclear structure.

  4. Nuclear Data

    Energy Technology Data Exchange (ETDEWEB)

    White, Morgan C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-01-23

    PowerPoint presentation targeted for educational use. Nuclear data comes from a variety of sources and in many flavors. Understanding where the data you use comes from and what flavor it is can be essential to understand and interpret your results. This talk will discuss the nuclear data pipeline with particular emphasis on providing links to additional resources that can be used to explore the issues you will encounter.

  5. Nuclear safety

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-07-01

    The Program on Nuclear Safety comprehends Radioprotection, Radioactive Waste Management and Nuclear Material Control. These activities are developed at the Nuclear Safety Directory. The Radioactive Waste Management Department (GRR) was formally created in 1983, to promote research and development, teaching and service activities in the field of radioactive waste. Its mission is to develop and employ technologies to manage safely the radioactive wastes generated at IPEN and at its customer’s facilities all over the country, in order to protect the health and the environment of today's and future generations. The Radioprotection Service (GRP) aims primarily to establish requirements for the protection of people, as workers, contractors, students, members of the general public and the environment from harmful effects of ionizing radiation. Furthermore, it also aims to establish the primary criteria for the safety of radiation sources at IPEN and planning and preparing for response to nuclear and radiological emergencies. The procedures about the management and the control of exposures to ionizing radiation are in compliance with national standards and international recommendations. Research related to the main activities is also performed. The Nuclear Material Control has been performed by the Safeguard Service team, which manages the accountability and the control of nuclear material at IPEN facilities and provides information related to these activities to ABACC and IAEA. (author)

  6. DNA binding domains in diverse nuclear receptors function as nuclear export signals.

    Science.gov (United States)

    Black, B E; Holaska, J M; Rastinejad, F; Paschal, B M

    2001-11-13

    The nuclear receptor superfamily of transcription factors directs gene expression through DNA sequence-specific interactions with target genes. Nuclear import of these receptors involves recognition of a nuclear localization signal (NLS) by importins, which mediate translocation into the nucleus. Nuclear receptors lack a leucine-rich nuclear export signal (NES), and export is insensitive to leptomycin B, indicating that nuclear export is not mediated by Crm1. We set out to define the NES in the glucocorticoid receptor (GR) and to characterize the export pathway. We found that the 69 amino acid DNA binding domain (DBD) of GR, which is unrelated to any known NES, is necessary and sufficient for export. Mutational analysis revealed that a 15 amino acid sequence between the two zinc binding loops in the GR-DBD confers nuclear export to a GFP reporter protein, and alanine-scanning mutagenesis was used to identify the residues within this sequence that are critical for export. The DBD is highly related (41%-88% identity) in steroid, nonsteroid, and orphan nuclear receptors, and we found that the DBDs from ten different nuclear receptors all function as export signals. DBD-dependent nuclear export is saturable, and prolonged nuclear localization of the GR increases its transcriptional activity. Multiple members of the nuclear receptor superfamily use a common pathway to exit the nucleus. We propose that NLS-mediated import and DBD-mediated export define a shuttling cycle that integrates the compartmentalization and activity of nuclear receptors.

  7. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... News Physician Resources Professions Site Index A-Z Children's (Pediatric) Nuclear Medicine Children’s (pediatric) nuclear medicine imaging ... the limitations of Children's Nuclear Medicine? What is Children's (Pediatric) Nuclear Medicine? Nuclear medicine is a branch ...

  8. Children's (Pediatric) Nuclear Medicine

    Science.gov (United States)

    ... Professions Site Index A-Z Children's (Pediatric) Nuclear Medicine Children’s (pediatric) nuclear medicine imaging uses small amounts ... Children's Nuclear Medicine? What is Children's (Pediatric) Nuclear Medicine? Nuclear medicine is a branch of medical imaging ...

  9. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... Professions Site Index A-Z Children's (Pediatric) Nuclear Medicine Children’s (pediatric) nuclear medicine imaging uses small amounts ... Children's Nuclear Medicine? What is Children's (Pediatric) Nuclear Medicine? Nuclear medicine is a branch of medical imaging ...

  10. General Nuclear Medicine

    Science.gov (United States)

    ... Resources Professions Site Index A-Z General Nuclear Medicine Nuclear medicine imaging uses small amounts of radioactive ... of General Nuclear Medicine? What is General Nuclear Medicine? Nuclear medicine is a branch of medical imaging ...

  11. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... Physician Resources Professions Site Index A-Z Children's (Pediatric) Nuclear Medicine Children’s (pediatric) nuclear medicine imaging uses ... limitations of Children's Nuclear Medicine? What is Children's (Pediatric) Nuclear Medicine? Nuclear medicine is a branch of ...

  12. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... Resources Professions Site Index A-Z Children's (Pediatric) Nuclear Medicine Children’s (pediatric) nuclear medicine imaging uses small ... of Children's Nuclear Medicine? What is Children's (Pediatric) Nuclear Medicine? Nuclear medicine is a branch of medical ...

  13. Nuclear Forensic Science: Analysis of Nuclear Material Out of Regulatory Control

    Science.gov (United States)

    Kristo, Michael J.; Gaffney, Amy M.; Marks, Naomi; Knight, Kim; Cassata, William S.; Hutcheon, Ian D.

    2016-06-01

    Nuclear forensic science seeks to identify the origin of nuclear materials found outside regulatory control. It is increasingly recognized as an integral part of a robust nuclear security program. This review highlights areas of active, evolving research in nuclear forensics, with a focus on analytical techniques commonly employed in Earth and planetary sciences. Applications of nuclear forensics to uranium ore concentrates (UOCs) are discussed first. UOCs have become an attractive target for nuclear forensic researchers because of the richness in impurities compared to materials produced later in the fuel cycle. The development of chronometric methods for age dating nuclear materials is then discussed, with an emphasis on improvements in accuracy that have been gained from measurements of multiple radioisotopic systems. Finally, papers that report on casework are reviewed, to provide a window into current scientific practice.

  14. Ilmenite-rich pyroclastic deposits - An ideal lunar resource

    Science.gov (United States)

    Hawke, B. R.; Clark, B.; Coombs, C. R.

    1990-01-01

    With a view of investigating possible economic benefits that a permanent lunar settlement might provide to the near-earth space infrastructures, consideration was given to the ilmenite-rich pyroclastic deposits as sources of oxygen (for use as a propellant) and He-3 (for nuclear fusion fuel). This paper demonstrates that ilmenite-rich pyroclastic deposits would be excellent sources of a wide variety of valuable elements besides O and He-3, including Fe, Ti, H2, N, C, S, Cu, Zn, Cd, Bi, and Pb. It is shown that several ilmenite-rich pyroclastic deposits of regional extent exist on the lunar surface. The suitability of regional pyroclastic deposits for lunar mining operations, construction activities, and the establishment of permanent lunar settlements is examined.

  15. Nuclear scales

    Energy Technology Data Exchange (ETDEWEB)

    Friar, J.L.

    1998-12-01

    Nuclear scales are discussed from the nuclear physics viewpoint. The conventional nuclear potential is characterized as a black box that interpolates nucleon-nucleon (NN) data, while being constrained by the best possible theoretical input. The latter consists of the longer-range parts of the NN force (e.g., OPEP, TPEP, the {pi}-{gamma} force), which can be calculated using chiral perturbation theory and gauged using modern phase-shift analyses. The shorter-range parts of the force are effectively parameterized by moments of the interaction that are independent of the details of the force model, in analogy to chiral perturbation theory. Results of GFMC calculations in light nuclei are interpreted in terms of fundamental scales, which are in good agreement with expectations from chiral effective field theories. Problems with spin-orbit-type observables are noted.

  16. Nuclear astrophysics

    Science.gov (United States)

    Penionzhkevich, Yu. E.

    2010-08-01

    The International Year of Astronomy 2009 (IYA2009) was declared by the 62nd General Assembly of the United Nations and was also endorsed by UNESCO. Investigations in the realms of particle and nuclear physicsmake a large contribution in the development of our ideas of the properties of the Universe. The present article discusses some problems of the evolution of the Universe, nucleosyntheses, and cosmochronology from the point of view of nuclear and particle physics. Processes occurring in the Universe are compared with the mechanisms of the production and decay of nuclei, as well as with the mechanisms of their interaction at high energies. Examples that demonstrate the potential of nuclearphysics methods for studying cosmic objects and the properties of the Universe are given. The results that come from investigations into nuclear reactions induced by beams of radioactive nuclei and which make it possible to take a fresh look at the nucleosynthesis scenario in the range at light nuclei are presented.

  17. Nuclear enthalpies

    Directory of Open Access Journals (Sweden)

    Rozynek Jacek

    2015-01-01

    Full Text Available Even small departures from a nuclear equilibrium density with constant nucleon masses require an increase of a nucleon enthalpy. This process can be described as volume corrections to a nucleon rest energy, which are proportional to pressure and absent in a standard Relativistic Mean Field (RMF with point-like nucleons. Bag model and RMF calculations show the modifications of nucleon mass, nucleon radius and a Parton Distribution Function (PDF of Nuclear Matter (NM above the saturation point originated from the pressure correction.

  18. Nuclear spectroscopy

    CERN Document Server

    Ajzenberg-Selove, Fay

    1960-01-01

    Nuclear Spectroscopy, Part A deals with the experimental and theoretical techniques involved in nuclear spectroscopy.This book discusses the interactions of charged particles with matter, gaseous ionization detectors, and particular mass attenuation coefficients. The magnetic gamma-ray spectrometers for photo or internal-conversion electrons, general characteristics of cross-section variation with energy, and measurement of fast neutron spectra are also elaborated. This text likewise covers the elastic scattering of photons by nuclei and measurement of widths of gamma-radiating levels.This pub

  19. Optics and radiators for RICH

    CERN Document Server

    Ekelöf, T J C

    1999-01-01

    An overview is given of the basic optics-design principles for Ring Imaging Cherenkov (RICH) counters in High-Energy Physics -- of the earlier evolution of these principles and of the new ideas and techniques that are currently being developed. The characteristics of the different gasses, liquids and solids that are employed as Cherenkov radiators, which are of fundamental importance to the optics design of a RICH counter, are also reviewed.

  20. An Improved Cluster Richness Estimator

    Energy Technology Data Exchange (ETDEWEB)

    Rozo, Eduardo; /Ohio State U.; Rykoff, Eli S.; /UC, Santa Barbara; Koester, Benjamin P.; /Chicago U. /KICP, Chicago; McKay, Timothy; /Michigan U.; Hao, Jiangang; /Michigan U.; Evrard, August; /Michigan U.; Wechsler, Risa H.; /SLAC; Hansen, Sarah; /Chicago U. /KICP, Chicago; Sheldon, Erin; /New York U.; Johnston, David; /Houston U.; Becker, Matthew R.; /Chicago U. /KICP, Chicago; Annis, James T.; /Fermilab; Bleem, Lindsey; /Chicago U.; Scranton, Ryan; /Pittsburgh U.

    2009-08-03

    Minimizing the scatter between cluster mass and accessible observables is an important goal for cluster cosmology. In this work, we introduce a new matched filter richness estimator, and test its performance using the maxBCG cluster catalog. Our new estimator significantly reduces the variance in the L{sub X}-richness relation, from {sigma}{sub lnL{sub X}}{sup 2} = (0.86 {+-} 0.02){sup 2} to {sigma}{sub lnL{sub X}}{sup 2} = (0.69 {+-} 0.02){sup 2}. Relative to the maxBCG richness estimate, it also removes the strong redshift dependence of the richness scaling relations, and is significantly more robust to photometric and redshift errors. These improvements are largely due to our more sophisticated treatment of galaxy color data. We also demonstrate the scatter in the L{sub X}-richness relation depends on the aperture used to estimate cluster richness, and introduce a novel approach for optimizing said aperture which can be easily generalized to other mass tracers.

  1. Nuclear energy.

    Science.gov (United States)

    Wilson, Peter D

    2010-01-01

    The technical principles and practices of the civil nuclear industry are described with particular reference to fission and its products, natural and artificial radioactivity elements principally concerned and their relationships, main types of reactor, safety issues, the fuel cycle, waste management, issues related to weapon proliferation, environmental considerations and possible future developments.

  2. Nuclear politics

    Science.gov (United States)

    Ranson, John

    2009-04-01

    The sentiments expressed by Sidney Drell in his forum article "The nuclear threat: a new start" (February pp16-17) are laudable, but it was disappointing to find this almost entirely political story in isolation. The article, which outlined the prospects for reducing weapons stockpiles under the new US administration, would have been more pertinent as an introduction to a series describing the technology used in detecting nuclear-testing activity. It would have been interesting to discuss the specific equipment and methods used, together with the analysis and correlation techniques - along with an indication of how sensitive and reliable they are (if the information is not classified). It is far easier to detect an explosive event than it is to detect and quantify weapons stores, which is a key factor for any negotiated solution. Apart from deductions based on actual inspection and satellite surveillance, are there other techniques that can be applied to this issue?

  3. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... are the limitations of Children's Nuclear Medicine? What is Children's (Pediatric) Nuclear Medicine? Nuclear medicine is a ... top of page What are some common uses of the procedure? Children's (pediatric) nuclear medicine imaging is ...

  4. NUCLEAR REACTOR

    Science.gov (United States)

    Grebe, J.J.

    1959-07-14

    High temperature reactors which are uniquely adapted to serve as the heat source for nuclear pcwered rockets are described. The reactor is comprised essentially of an outer tubular heat resistant casing which provides the main coolant passageway to and away from the reactor core within the casing and in which the working fluid is preferably hydrogen or helium gas which is permitted to vaporize from a liquid storage tank. The reactor core has a generally spherical shape formed entirely of an active material comprised of fissile material and a moderator material which serves as a diluent. The active material is fabricated as a gas permeable porous material and is interlaced in a random manner with very small inter-connecting bores or capillary tubes through which the coolant gas may flow. The entire reactor is divided into successive sections along the direction of the temperature gradient or coolant flow, each section utilizing materials of construction which are most advantageous from a nuclear standpoint and which at the same time can withstand the operating temperature of that particular zone. This design results in a nuclear reactor characterized simultaneously by a minimum critiral size and mass and by the ability to heat a working fluid to an extremely high temperature.

  5. Hydrogen-rich gas generator

    Science.gov (United States)

    Houseman, J.; Cerini, D. J. (Inventor)

    1976-01-01

    A process and apparatus are described for producing hydrogen-rich product gases. A spray of liquid hydrocarbon is mixed with a stream of air in a startup procedure and the mixture is ignited for partial oxidation. The stream of air is then heated by the resulting combustion to reach a temperature such that a signal is produced. The signal triggers a two way valve which directs liquid hydrocarbon from a spraying mechanism to a vaporizing mechanism with which a vaporized hydrocarbon is formed. The vaporized hydrocarbon is subsequently mixed with the heated air in the combustion chamber where partial oxidation takes place and hydrogen-rich product gases are produced.

  6. The NA62 RICH detector

    Energy Technology Data Exchange (ETDEWEB)

    Lenti, Massimo, E-mail: lenti@fi.infn.i [Sezione dell' INFN di Firenze, I-50019 Sesto Fiorentino (Italy)

    2011-05-21

    The NA62 RICH must separate charged pions from muons in a 15-35 GeV/c momentum range. The detector will have a 17 m long, 4 m wide cylindrical vessel, filled with neon at an atmospheric pressure. A mosaic of 20 mirrors, with 17 m focal length will be placed at the downstream end of the vessel while 2000 single anode photomultipliers will be placed at the upstream part. Two test beams were held at CERN in 2007 and 2009 with a RICH prototype. A muon suppression factor greater than 100 was validated.

  7. Nuclear photonics

    Science.gov (United States)

    Habs, D.; Günther, M. M.; Jentschel, M.; Thirolf, P. G.

    2012-07-01

    With the planned new γ-beam facilities like MEGa-ray at LLNL (USA) or ELI-NP at Bucharest (Romania) with 1013 γ/s and a band width of ΔEγ/Eγ≈10-3, a new era of γ beams with energies up to 20MeV comes into operation, compared to the present world-leading HIγS facility at Duke University (USA) with 108 γ/s and ΔEγ/Eγ≈3ṡ10-2. In the long run even a seeded quantum FEL for γ beams may become possible, with much higher brilliance and spectral flux. At the same time new exciting possibilities open up for focused γ beams. Here we describe a new experiment at the γ beam of the ILL reactor (Grenoble, France), where we observed for the first time that the index of refraction for γ beams is determined by virtual pair creation. Using a combination of refractive and reflective optics, efficient monochromators for γ beams are being developed. Thus, we have to optimize the total system: the γ-beam facility, the γ-beam optics and γ detectors. We can trade γ intensity for band width, going down to ΔEγ/Eγ≈10-6 and address individual nuclear levels. The term "nuclear photonics" stresses the importance of nuclear applications. We can address with γ-beams individual nuclear isotopes and not just elements like with X-ray beams. Compared to X rays, γ beams can penetrate much deeper into big samples like radioactive waste barrels, motors or batteries. We can perform tomography and microscopy studies by focusing down to μm resolution using Nuclear Resonance Fluorescence (NRF) for detection with eV resolution and high spatial resolution at the same time. We discuss the dominating M1 and E1 excitations like the scissors mode, two-phonon quadrupole octupole excitations, pygmy dipole excitations or giant dipole excitations under the new facet of applications. We find many new applications in biomedicine, green energy, radioactive waste management or homeland security. Also more brilliant secondary beams of neutrons and positrons can be produced.

  8. Experimental study of neutron-skin thicknesses in neutron-rich isotopes

    CERN Document Server

    Krasznahorkay, A; Gulyás, J; Adrich, P; Aumann, T; Datta-Pramanik, U; Emling, H; Nociforo, C; Rudrajyoti, P; Simon, H

    2003-01-01

    The difference between the neutron and proton radii of a heavy stable nucleus is of the order of a few percent. The precise knowledge of the symmetry energy is essential not only for describing the structure of neutron-rich nuclei, but also for describing the properties of the neutron-rich matter in nuclear astrophysics. A new tool was introduced for studying the neutron-skin thickness, by exciting the spin-dipole resonance (SDR). (R.P.)

  9. Phosphorylation Drives a Dynamic Switch in Serine/Arginine-Rich Proteins

    OpenAIRE

    Xiang, ShengQi; Gapsys, Vytautas; Kim, Hai-Young; Bessonov, Sergey; Hsiao, He-Hsuan; Möhlmann, Sina; Klaukien, Volker; Ficner, Ralf; Becker, Stefan; Urlaub, Henning; Lührmann, Reinhard; de Groot, Bert; Zweckstetter, Markus

    2013-01-01

    Serine/arginine-rich (SR) proteins are important players in RNA metabolism and are extensively phosphorylated at serine residues in RS repeats. Here, we show that phosphorylation switches the RS domain of the serine/arginine-rich splicing factor 1 from a fully disordered state to a partially rigidified arch-like structure. Nuclear magnetic resonance spectroscopy in combination with molecular dynamics simulations revealed that the conformational switch is restricted to RS repeats, critically d...

  10. Nuclear tele medicine; Telemedicina nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Vargas, L.; Hernandez, F.; Fernandez, R. [Departamento de Medicina Nuclear, Imagenologia Diagnostica, Xalapa, Veracruz (Mexico)

    2005-07-01

    The great majority of the digital images of nuclear medicine are susceptible of being sent through internet. This has allowed that the work in diagnosis cabinets by image it can benefit of this modern technology. We have presented in previous congresses works related with tele medicine, however, due to the speed in the evolution of the computer programs and the internet, becomes necessary to make a current position in this modality of work. (Author)

  11. Fifth International Conference on Fission and Properties of Neutron-Rich Nuclei

    CERN Document Server

    Ramayya, A V; ICFN5

    2014-01-01

    These proceedings are the fifth in the series of International Conferences covering fission and properties of neutron-rich nuclei, which are at the forefront of nuclear research. The time interval of 5 years between each conference allows for significant new results to be achieved. Recently, world leaders in theory and experiments in research and the development of new facilities for research presented their latest results in areas such as synthesis of superheavy elements, new facilities for and recent results with radioactive ion beams, structure of neutron-rich nuclei, nuclear fission process, fission yields and nuclear astrophysics. This book is a major source of the latest research in these areas and plans for the future. The conference brought together a unique group of over 100 speakers including leaders from the major nuclear laboratories in Canada, China, France, Finland, Germany, Italy, Japan, Russia, Switerzland and the US along with leading research scientists from around the world.

  12. Authentic Assessment through Rich Tasks

    Science.gov (United States)

    Wrigley, Terry

    2017-01-01

    This short article explains the key principles of "rich tasks," a version of authentic assessment developed in Queensland, Australia, as part of a major curriculum development called the "New Basics." In various documents, the project leaders recognised the danger that inappropriate assessment would undermine the proposed…

  13. Rich-cores in networks

    CERN Document Server

    Ma, Athen

    2014-01-01

    A core is said to be a group of central and densely connected nodes which governs the overall behavior of a network. Profiling this meso--scale structure currently relies on a limited number of methods which are often complex, and have scalability issues when dealing with very large networks. As a result, we are yet to fully understand its impact on network properties and dynamics. Here we introduce a simple method to profile this structure by combining the concepts of core/periphery and rich-club. The key challenge in addressing such association of the two concepts is to establish a way to define the membership of the core. The notion of a "rich-club" describes nodes which are essentially the hub of a network, as they play a dominating role in structural and functional properties. Interestingly, the definition of a rich-club naturally emphasizes high degree nodes and divides a network into two subgroups. Our approach theoretically couples the underlying principle of a rich-club with the escape time of a rand...

  14. The STAR-RICH Detector

    CERN Document Server

    Lasiuk, B; Braem, André; Cozza, D; Davenport, M; De Cataldo, G; Dell'Olio, L; Di Bari, D; Di Mauro, A; Dunlop, J C; Finch, E; Fraissard, Daniel; Franco, A; Gans, J; Ghidini, B; Harris, J W; Horsley, M; Kunde, G J; Lasiuk, B; Lesenechal, Y; Majka, R D; Martinengo, P; Morsch, Andreas; Nappi, E; Paic, G; Piuz, François; Posa, F; Raynaud, J; Salur, S; Sandweiss, J; Santiard, Jean-Claude; Satinover, J; Schyns, E M; Smirnov, N; Van Beelen, J; Williams, T D; Xu, Z

    2002-01-01

    The STAR-RICH detector extends the particle idenfication capabilities of the STAR spectrometer for charged hadrons at mid-rapidity. It allows identification of pions and kaons up to ~3 GeV/c and protons up to ~5 GeV/c. The characteristics and performance of the device in the inaugural RHIC run are described.

  15. The STAR-RICH Detector

    OpenAIRE

    Andrés, Yu; Braem, André; Cozza, D; Davenport, M; De Cataldo, G; Dell'Olio, L; Di Bari, D; Di Mauro, A.; Dunlop, J C; Finch, E; Fraissard, Daniel; Franco, A; Gans, J.; Ghidini, B.; Harris, J.W.

    2001-01-01

    The STAR-RICH detector extends the particle idenfication capabilities of the STAR spectrometer for charged hadrons at mid-rapidity. It allows identification of pions and kaons up to ~3 GeV/c and protons up to ~5 GeV/c. The characteristics and performance of the device in the inaugural RHIC run are described.

  16. RICH pattern recognition for LHCb

    CERN Document Server

    Forty, Roger W

    1999-01-01

    An algorithm for performing pattern recognition in RICH detectors is described. It uses a maximum-likelihood technique, comparing the predicted and observed distributions of detected photoelectrons. The algorithm is able to handle regions of high track density, for which LHCb provides a good example. (5 refs).

  17. SOFTWARE SUPPORT FOR RICH PICTURES

    DEFF Research Database (Denmark)

    Valente, Andrea; Marchetti, Emanuela

    2010-01-01

    Rich pictures (RP) are common in object-oriented analysis and design courses, but students seem to have problems in integrating them in their projects' workflow. A new software tool is being developed, specific for RP authoring. To better understand students' issues and working practice with RP...

  18. Applications of nuclear physics

    Science.gov (United States)

    Hayes, A. C.

    2017-02-01

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion. The review then moves to focus on modern applications of these concepts, including the basic concepts and diagnostics developed for the forensics of nuclear explosions, the nuclear diagnostics at the National Ignition Facility, nuclear reactor safeguards, and the detection of nuclear material production and trafficking. The review also summarizes recent developments in nuclear geophysics and nuclear medicine. The nuclear geophysics areas discussed include geo-chronology, nuclear logging for industry, the Oklo reactor, and geo-neutrinos. The section on nuclear medicine summarizes the critical advances in nuclear imaging, including PET and SPECT imaging, targeted radionuclide therapy, and the nuclear physics of medical isotope production. Each subfield discussed requires a review article unto itself, which is not the intention of the current review; rather, the current review is intended for readers who wish to get a broad understanding of applied nuclear physics.

  19. Applications of nuclear physics.

    Science.gov (United States)

    Hayes, A C

    2017-02-01

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion. The review then moves to focus on modern applications of these concepts, including the basic concepts and diagnostics developed for the forensics of nuclear explosions, the nuclear diagnostics at the National Ignition Facility, nuclear reactor safeguards, and the detection of nuclear material production and trafficking. The review also summarizes recent developments in nuclear geophysics and nuclear medicine. The nuclear geophysics areas discussed include geo-chronology, nuclear logging for industry, the Oklo reactor, and geo-neutrinos. The section on nuclear medicine summarizes the critical advances in nuclear imaging, including PET and SPECT imaging, targeted radionuclide therapy, and the nuclear physics of medical isotope production. Each subfield discussed requires a review article unto itself, which is not the intention of the current review; rather, the current review is intended for readers who wish to get a broad understanding of applied nuclear physics.

  20. Yeast Interacting Proteins Database: YHR156C, YJR010W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YHR156C LIN1 Non-essential component of U5 snRNP; nuclear protein; physically inter...6C Bait gene name LIN1 Bait description Non-essential component of U5 snRNP; nuclear protein; physically

  1. Dictionary of nuclear engineering

    Energy Technology Data Exchange (ETDEWEB)

    Sube, R.

    1985-01-01

    Ralf Sube, an experienced compiler of three wellknown four-language reference works has now prepared this glossary of nuclear engineering terms in English, German, French and Russian. Based on the proven lexicography of the Technik-Worterbuch series, it comprises about 30,000 terms in each language covering the following: Nuclear and Atomic Physics; Nuclear Radiation and Isotopes; Nuclear Materials; Nuclear Facilties; Nuclear Power Industry; Nuclear Weapons.

  2. Applications of Nuclear Physics

    OpenAIRE

    Hayes, Anna C.

    2017-01-01

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that und...

  3. Fission and Properties of Neutron-Rich Nuclei

    Science.gov (United States)

    Hamilton, Joseph H.; Ramayya, A. V.; Carter, H. K.

    2008-08-01

    Opening session. Nuclear processes in stellar explosions / M. Wiescher. In-beam [symbol]-ray spectroscopy of neutron-rich nuclei at NSCL / A. Gade -- Nuclear structure I. Shell-model structure of neutron-rich nuclei beyond [symbol]Sn / A. Covello ... [et al.]. Shell structure and evolution of collectivity in nuclei above the [symbol]Sn core / S. Sarkar and M. S. Sarkar. Heavy-ion fusion using density-constrained TDHF / A. S. Umar and V. E. Oberacker. Towards an extended microscopic theory for upper-fp shell nuclei / K. P. Drumev. Properties of the Zr and Pb isotopes near the drip-line / V. N. Tarasov ... [et al.]. Identification of high spin states in [symbol] Cs nuclei and shell model calculations / K. Li ... [et al.]. Recent measurements of spherical and deformed isomers using the Lohengrin fission-fragment spectrometer / G. S. Simpson ... [et al.] -- Nuclear structure II. Nuclear structure investigation with rare isotope spectroscopic investigations at GSI / P. Boutachkov. Exploring the evolution of the shell structures by means of deep inelastic reactions / G. de Anaelis. Probing shell closures in neutron-rich nuclei / R. Krücken for the S277 and REX-ISOLDEMINIBALL collaborations. Structure of Fe isotopes at the limits of the pf-shell / N. Hoteling ... [et al.]. Spectroscopy of K isomers in shell-stabilized trans-fermium nuclei / S. K. Tandel ... [et al.] -- Radioactive ion beam facilities. SPIRAL2 at GANIL: a world leading ISOL facility for the next decade / S. Gales. New physics at the International Facility for Antiproton and Ion Research (FAIR) next to GSI / I. Augustin ... [et al.]. Radioactive beams from a high powered ISOL system / A. C. Shotter. RlKEN RT beam factory / T. Motobayashi. NSCL - ongoing activities and future perspectives / C. K. Gelbke. Rare isotope beams at Argonne / W. F. Henning. HRIBF: scientific highlights and future prospects / J. R. Beene. Radioactive ion beam research done in Dubna / G. M. Ter-Akopian ... [et al.] -- Fission I

  4. Growth and alteration of uranium-rich microlite

    Energy Technology Data Exchange (ETDEWEB)

    Giere, R.; Swope, R. J.; Buck, E. C.; Guggenheim, R.; Mathys, D.; Reusser, E.

    2000-02-01

    Uranium-rich microlite, a pyrochlore-group mineral, occurs in 440 Ma old lithium pegmatites of the Mozambique Belt in East Africa. Microlite exhibits a pronounced growth zoning, with a U-free core surrounded by a U-rich rim (UO{sub 2} up to 17 wt.%). The core exhibits conjugate sets of straight cracks (cleavage planes) which provided pathways for a late-stage U-enriched pegmatitic fluid which interacted with the U-free microlite to produce a distinct U enrichment along the cracks and led to the formation of the U-rich rim. Following the stage of U incorporation into microlite, a second generation of hydrothermal fluids deposited mica along the cleavage planes. Subsequent to these two hydrothermal stages, the host rock was uplifted and subjected to intense low-temperature alteration during which Na, Ca and F were leached from the microlite crystals. This alteration also led to a hydration of microlite, but there is no evidence of U loss. These low-temperature alteration effects were only observed in the U-rich rim which is characterized by a large number of irregular cracks which are most probably the result of metamictization, as indicated by electron diffraction images and powder X-ray patterns. The pyrochlore-group minerals provide excellent natural analogues for pyrochlore-based nuclear waste forms, because samples of variable age and with high actinide contents are available.

  5. Tom W. Bonner Prize in Nuclear Physics Lecture: The limits of nuclear landscape

    Science.gov (United States)

    Nazarewicz, Witold

    2012-03-01

    Understanding nuclei is a quantum many-body problem of incredible richness and diversity and studies of nuclei address some of the great challenges that are common throughout modern science. Nuclear structure research strives to build a unified and comprehensive microscopic framework in which bulk nuclear properties, nuclear excitations, and nuclear reactions can all be described. A new and exciting focus in this endeavor lies in the description of exotic and short-lived nuclei at the limits of proton-to-neutron asymmetry, mass, and angular momentum. In this talk, advances in the nuclear density functional theory will be reviewed in the context of the main scientific questions, experimental developments, and the advent of extreme-scale computing platforms.

  6. Fuel-Rich Catalytic Combustion

    Science.gov (United States)

    Brabbs, Theodore A.; Olson, Sandra L.

    1987-01-01

    Two-stage combustion system reduces particulate emissions. Program on catalytic oxidation of iso-octane demonstrates feasibility of two-stage combustion system for reducing particulate emissions. With fuel-rich (fuel/air equivalence ratios of 4.8 to 7.8) catalytic-combustion preburner as first stage, combustion process free of soot at reactor-outlet temperatures of 1,200 K or less.

  7. NUCLEAR REACTOR

    Science.gov (United States)

    Miller, H.I.; Smith, R.C.

    1958-01-21

    This patent relates to nuclear reactors of the type which use a liquid fuel, such as a solution of uranyl sulfate in ordinary water which acts as the moderator. The reactor is comprised of a spherical vessel having a diameter of about 12 inches substantially surrounded by a reflector of beryllium oxide. Conventionnl control rods and safety rods are operated in slots in the reflector outside the vessel to control the operation of the reactor. An additional means for increasing the safety factor of the reactor by raising the ratio of delayed neutrons to prompt neutrons, is provided and consists of a soluble sulfate salt of beryllium dissolved in the liquid fuel in the proper proportion to obtain the result desired.

  8. On China's Nuclear Doctrine

    Directory of Open Access Journals (Sweden)

    Xia Liping

    2015-12-01

    Full Text Available Nuclear weapons have played an important role in China's national strategy. China’s nuclear doctrine has a very strong continuity. Nevertheless, China has made readjustments in its nuclear doctrine according to the changes of its internal and external situation and its general strategic threat perception. China’s nuclear doctrine has experienced a process of evolution from anti-nuclear blackmail to minimum deterrence. There are five major parts in China's nuclear doctrine: policy of declaration, nuclear development, nuclear deployment, nuclear employment, and nuclear disarmament. Because China is faced with a different situation from other nuclear powers and has its own strategic culture, China has a nuclear doctrine with its own characteristics. China’s nuclear doctrine has been affiliated with and has served the national development strategy, national security strategy, national defense policy and military strategy of China.

  9. Reconversion of nuclear weapons

    CERN Document Server

    Kapitza, Sergei P

    1992-01-01

    The nuclear predicament or nuclear option. Synopsis of three lectures : 1- The physical basis of nuclear technology. Physics of fission. Chain reaction in reactors and weapons. Fission fragments. Separration of isotopes. Radiochemistry.2- Nuclear reactors with slow and fast neutrons. Power, size, fuel and waste. Plutonium production. Dose rate, shielding and health hazard. The lessons of Chernobyl3- Nuclear weapons. Types, energy, blast and fallout. Fusion and hydrogen bombs. What to do with nuclear weapons when you cannot use them? Testing. Nonmilittary use. Can we get rid of the nuclear weapon? Nuclear proliferation. Is there a nuclear future?

  10. Nuclear fuels

    Energy Technology Data Exchange (ETDEWEB)

    Beauvy, M.; Berthoud, G.; Defranceschi, M.; Ducros, G.; Guerin, Y.; Limoge, Y.; Madic, Ch.; Santarini, G.; Seiler, J.M.; Sollogoub, P.; Vernaz, E.; Guillet, J.L.; Ballagny, A.; Bechade, J.L.; Bonin, B.; Brachet, J.Ch.; Delpech, M.; Dubois, S.; Ferry, C.; Freyss, M.; Gilbon, D.; Grouiller, J.P.; Iracane, D.; Lansiart, S.; Lemoine, P.; Lenain, R.; Marsault, Ph.; Michel, B.; Noirot, J.; Parrat, D.; Pelletier, M.; Perrais, Ch.; Phelip, M.; Pillon, S.; Poinssot, Ch.; Vallory, J.; Valot, C.; Pradel, Ph.; Bonin, B.; Bouquin, B.; Dozol, M.; Lecomte, M.; Vallee, A.; Bazile, F.; Parisot, J.F.; Finot, P.; Roberts, J.F

    2009-07-01

    Fuel is one of the essential components in a reactor. It is within that fuel that nuclear reactions take place, i.e. fission of heavy atoms, uranium and plutonium. Fuel is at the core of the reactor, but equally at the core of the nuclear system as a whole. Fuel design and properties influence reactor behavior, performance, and safety. Even though it only accounts for a small part of the cost per kilowatt-hour of power provided by current nuclear power plants, good utilization of fuel is a major economic issue. Major advances have yet to be achieved, to ensure longer in-reactor dwell-time, thus enabling fuel to yield more energy; and improve ruggedness. Aside from economics, and safety, such strategic issues as use of plutonium, conservation of resources, and nuclear waste management have to be addressed, and true technological challenges arise. This Monograph surveys current knowledge regarding in-reactor behavior, operating limits, and avenues for R and D. It also provides illustrations of ongoing research work, setting out a few noteworthy results recently achieved. Content: 1 - Introduction; 2 - Water reactor fuel: What are the features of water reactor fuel? 9 (What is the purpose of a nuclear fuel?, Ceramic fuel, Fuel rods, PWR fuel assemblies, BWR fuel assemblies); Fabrication of water reactor fuels (Fabrication of UO{sub 2} pellets, Fabrication of MOX (mixed uranium-plutonium oxide) pellets, Fabrication of claddings); In-reactor behavior of UO{sub 2} and MOX fuels (Irradiation conditions during nominal operation, Heat generation, and removal, The processes involved at the start of irradiation, Fission gas behavior, Microstructural changes); Water reactor fuel behavior in loss of tightness conditions (Cladding, the first containment barrier, Causes of failure, Consequences of a failure); Microscopic morphology of fuel ceramic and its evolution under irradiation; Migration and localization of fission products in UOX and MOX matrices (The ceramic under

  11. Reactions with fast radioactive beams of neutron-rich nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Aumann, T. [Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany)

    2005-11-01

    The neutron dripline has presently been reached only for the lightest nuclei up to the element oxygen. In this region of light neutron-rich nuclei, scattering experiments are feasible even for dripline nuclei by utilizing high-energy secondary beams produced by fragmentation. In the present article, reactions of high-energy radioactive beams will be exemplified using recent experimental results mainly derived from measurements of breakup reactions performed at the LAND and FRS facilities at GSI and at the S800 spectrometer at the NSCL. Nuclear and electromagnetically induced reactions allow probing different aspects of nuclear structure at the limits of stability related to the neutron-proton asymmetry and the weak binding close to the dripline. Properties of the valence-neutron wave functions are studied in the one-neutron knockout reaction, revealing the changes of shell structure when going from the beta-stability line to more asymmetric loosely bound neutron-rich systems. The vanishing of the N=8 shell gap for neutron-rich systems like {sup 11}Li and {sup 12}Be, or the new closed N=14, 16 shells for the oxygen isotopes are examples. The continuum of weakly bound nuclei and halo states can be studied by inelastic scattering. The dipole response, for instance, is found to change dramatically when going away from the valley of stability. A redistribution of the dipole strength towards lower excitation energies is observed for neutron-rich nuclei, which partly might be due to a new collective excitation mode related to the neutron-proton asymmetry. Halo nuclei in particular show strong dipole transitions to the continuum at the threshold, being directly related to the ground-state properties of the projectile. Finally, an outlook on future experimental prospects is given. (orig.)

  12. Trends in Nuclear Astrophysics

    OpenAIRE

    Schatz, Hendrik

    2016-01-01

    Nuclear Astrophysics is a vibrant field at the intersection of nuclear physics and astrophysics that encompasses research in nuclear physics, astrophysics, astronomy, and computational science. This paper is not a review. It is intended to provide an incomplete personal perspective on current trends in nuclear astrophysics and the specific role of nuclear physics in this field.

  13. The nuclear physics of neutron stars

    Energy Technology Data Exchange (ETDEWEB)

    Piekarewicz, J. [Department of Physics, Florida State University, Tallahassee, 32306 Florida (United States)

    2008-12-15

    A remarkable fact about spherically-symmetric neutron stars in hydrostatic equilibrium - the so-called Schwarzschild stars - is that the only physics that they are sensitive to is the equation of state of neutron-rich matter. As such, neutron stars provide a myriad of observables that may be used to constrain poorly known aspects of the nuclear interaction under extreme conditions of density. After discussing many of the fascinating phases encountered in neutron stars, I will address how powerful theoretical, experimental, and observational constraints may be used to place stringent limits on the equation of state of neutron-rich matter. (Author)

  14. Continuum excitations in neutron-rich Oxygen isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Aumann, T.; Boretzky, K.; Cortina, D.; Cub, J.; Emling, H.; Geissel, H.; Hellstroem, M.; Holzmann, R.; Ilievski, S.; Iwasa, N.; Kaspar, M.; Kleinboehl, A.; Leifels, Y.; Muenzenberg, G.; Rejmund, M.; Scheidenberger, C.; Schlegel, C.; Suemmerer, K.; Wan, S. [Gesellschaft fuer Schwerionenforschung (GSI), Planckstr. 1, D-64291 Darmstadt (Germany); Aumann, T.; Boretzky, K.; Dostal, W.; Eberlein, B.; Kratz, J.V. [Institut fuer Kernchemie, Johannes Gutenberg Universitaet, D-55099 Mainz (Germany); Leistenschneider, A.; Elze, T.W.; Gruenschloss, A.; Stroth, J. [Institut fuer Kernphysik, Johann Wolfgang Goethe Universitaet, D-60486 Frankfurt (Germany); Cub, J.; Simon, H. [Institut fuer Kernphysik, Technische Universitaet, D-64289 Darmstadt (Germany); Holeczek, J. [Instytut Fizyki, Uniwersytet Slaski, PL-40-007 Katowice (Poland); Kulessa, R.; Lubkiewicz, E.; Wajda, E.; Walus, W. [Instytut Fizyki, Uniwersytet Jagellonski, PL-30-059 Krakow (Poland); Reiter, P. [Argonne National Laboratory, Argonne, Illinois 60439 (United States)

    1998-12-01

    Electromagnetic and nuclear excitations of the neutron-rich Oxygen isotopes ranging from A=17 to A=22 are studied experimentally in reactions at energies around 600 MeV/u. By measuring the four-momenta of all decay products the excitation energy is determined. From the differential cross sections for electromagnetic excitation, the E1-strength distributions can be deduced. For {sup 18,20,22}O, low-lying dipole strength is observed, exhausting about 5{percent} of the energy weighted TRK sumrule for energies up to 5 MeV above the continuum threshold. {copyright} {ital 1998 American Institute of Physics.}

  15. Nuclear voices: A book of quotations and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Bollen, P.

    1986-01-01

    A representative cross-section of observations, viewpoints, and commentary on life in the nuclear age, this anthology features the diverse opinions of government leaders, scholars, scientists, historians, and others on the psychological, economic, religious, environmental, military, and political implications of the nuclear threat. From the controversy over nuclear energy to the complexities of the nuclear arms race, this rich polemic of ideas and reactions includes quotations by Sagan, Einstein, Oppenheimer, Brezhnev, and Schweitzer, among others, as well as personal statements by distinguished individuals from a variety of fields-written specifically for this volume.

  16. Dipole polarizability of neutron rich nuclei and the symmetry energy

    Energy Technology Data Exchange (ETDEWEB)

    Horvat, Andrea; Johansen, Jacob; Miki, Kenjiro; Schindler, Fabia; Schrock, Philipp [IKP, TU Darmstadt (Germany); Aumann, Thomas [IKP, TU Darmstadt (Germany); GSI, Darmstadt (Germany); Boretzky, Konstanze [GSI, Darmstadt (Germany); Collaboration: R3B-Collaboration

    2015-07-01

    As a part of a systematic investigation of the dipole response of stable up to very neutron rich tin isotopes, nuclear and electromagnetic excitation of {sup 124}Sn-{sup 134}Sn has been investigated at relativistic energies in inverse kinematics induced by carbon and lead targets at the LAND-R3B setup at GSI in Darmstadt. The electric dipole response and the nuclear reaction cross section, total and charge-changing, are obtained from the kinematically complete determination of momenta of all particles on an event by event basis. The dipole polarizability is extracted from the Coulomb excitation interaction channel, in order to make use of relevant correlations of this observable with nuclear matter properties such as the symmetry energy at saturation density (J) and it's slope (L). The systematics of the low-lying ''pygmy'' dipole strength, the giant dipole resonance (GDR) and the neutron skin thickness are determined with respect to increasing isospin asymmetry. This talk also discusses the correlations and sensitivities of these variables and observables obtained within the framework of nuclear energy density functional theory.

  17. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... What are the limitations of Children's Nuclear Medicine? What is Children's (Pediatric) Nuclear Medicine? Nuclear medicine is ... this time is PET/MRI. top of page What are some common uses of the procedure? Children's ( ...

  18. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... previous nuclear medicine exam. top of page What are the limitations of Children's (Pediatric) Nuclear Medicine? Nuclear medicine procedures can be time consuming. It can take several hours to days ...

  19. Mean nuclear volume

    DEFF Research Database (Denmark)

    Mogensen, O.; Sørensen, Flemming Brandt; Bichel, P.

    1999-01-01

    We evaluated the following nine parameters with respect to their prognostic value in females with endometrial cancer: four stereologic parameters [mean nuclear volume (MNV), nuclear volume fraction, nuclear index and mitotic index], the immunohistochemical expression of cancer antigen (CA125...

  20. Nuclear Quadrupole Moments and Nuclear Shell Structure

    Science.gov (United States)

    Townes, C. H.; Foley, H. M.; Low, W.

    1950-06-23

    Describes a simple model, based on nuclear shell considerations, which leads to the proper behavior of known nuclear quadrupole moments, although predictions of the magnitudes of some quadrupole moments are seriously in error.

  1. Alternative Approach to Nuclear Data Representation

    Energy Technology Data Exchange (ETDEWEB)

    Pruet, J; Brown, D; Beck, B; McNabb, D P

    2005-07-27

    This paper considers an approach for representing nuclear data that is qualitatively different from the approach currently adopted by the nuclear science community. Specifically, they examine a representation in which complicated data is described through collections of distinct and self contained simple data structures. This structure-based representation is compared with the ENDF and ENDL formats, which can be roughly characterized as dictionary-based representations. A pilot data representation for replacing the format currently used at LLNL is presented. Examples are given as is a discussion of promises and shortcomings associated with moving from traditional dictionary-based formats to a structure-rich or class-like representation.

  2. Nuclear energy data 2010

    CERN Document Server

    2010-01-01

    This 2010 edition of Nuclear Energy Data , the OECD Nuclear Energy Agency's annual compilation of official statistics and country reports on nuclear energy, provides key information on plans for new nuclear plant construction, nuclear fuel cycle developments as well as current and projected nuclear generating capacity to 2035 in OECD member countries. This comprehensive overview provides authoritative information for policy makers, experts and other interested stakeholders.

  3. Nuclear Fuel Cycle & Vulnerabilities

    Energy Technology Data Exchange (ETDEWEB)

    Boyer, Brian D. [Los Alamos National Laboratory

    2012-06-18

    The objective of safeguards is the timely detection of diversion of significant quantities of nuclear material from peaceful nuclear activities to the manufacture of nuclear weapons or of other nuclear explosive devices or for purposes unknown, and deterrence of such diversion by the risk of early detection. The safeguards system should be designed to provide credible assurances that there has been no diversion of declared nuclear material and no undeclared nuclear material and activities.

  4. Nuclear weapons modernizations

    Energy Technology Data Exchange (ETDEWEB)

    Kristensen, Hans M. [Federation of American Scientists, Washington, DC (United States)

    2014-05-09

    This article reviews the nuclear weapons modernization programs underway in the world's nine nuclear weapons states. It concludes that despite significant reductions in overall weapons inventories since the end of the Cold War, the pace of reductions is slowing - four of the nuclear weapons states are even increasing their arsenals, and all the nuclear weapons states are busy modernizing their remaining arsenals in what appears to be a dynamic and counterproductive nuclear competition. The author questions whether perpetual modernization combined with no specific plan for the elimination of nuclear weapons is consistent with the nuclear Non-Proliferation Treaty and concludes that new limits on nuclear modernizations are needed.

  5. Nuclear energy data 2011

    CERN Document Server

    2011-01-01

     . Nuclear Energy Data, the OECD Nuclear Energy Agency's annual compilation of statistics and country reports on nuclear energy, contains official information provided by OECD member country governments on plans for new nuclear plant construction, nuclear fuel cycle developments as well as current and projected nuclear generating capacity to 2035. For the first time, it includes data for Chile, Estonia, Israel and Slovenia, which recently became OECD members. Key elements of this edition show a 2% increase in nuclear and total electricity production and a 0.5% increase in nuclear generating ca

  6. Nuclear Masses and Neutron Stars

    CERN Document Server

    Kreim, Susanne; Lunney, David; Schaffner-Bielich, Jürgen

    2013-01-01

    Precision mass spectrometry of neutron-rich nuclei is of great relevance for astrophysics. Masses of exotic nuclides impose constraints on models for the nuclear interaction and thus affect the description of the equation of state of nuclear matter, which can be extended to describe neutron-star matter. With knowledge of the masses of nuclides near shell closures, one can also derive the neutron-star crustal composition. The Penning-trap mass spectrometer ISOLTRAP at CERN-ISOLDE has recently achieved a breakthrough measuring the mass of 82Zn, which allowed constraining neutron-star crust composition to deeper layers (Wolf et al., PRL 110, 2013). We perform a more detailed study on the sequence of nuclei in the outer crust of neutron stars with input from different nuclear models to illustrate the sensitivity to masses and the robustness of neutron-star models. The dominant role of the N=50 and N=82 closed neutron shells for the crustal composition is confirmed.

  7. RICH for P¯ANDA

    Science.gov (United States)

    Schepers, G.; Bettoni, D.; Branford, D.; Britting, A.; Carassiti, V.; Cecchi, A.; Dodokhof, V. Kh.; Düren, M.; Ehrenfried, M.; Eyrich, W.; Föhl, K.; Glazier, D.; Hoek, M.; Hohler, R.; Kaiser, R.; Lehmann, A.; Lehmann, D.; Lu, S.; Marton, J.; Merle, O.; Peters, K.; Pizzolotto, C.; Rosner, G.; Schmidt, R.; Schmitt, L.; Schönmeier, P.; Schwarz, C.; Seitz, B.; Sfienti, C.; Suzuki, K.; Teufel, A.; Vodopianov, A. S.; Watts, D.

    2009-01-01

    The powerful particle identification detection system of the P¯ANDA (antiProton ANihilations at DArmstadt) experiment contains three Cherenkov detectors. In the forward direction a conventional RICH detector is planned. In the high solenoid field of the target spectrometer thin Cherenkov detectors using the DIRC principle are mandatory and are envisaged in the form of a barrel and a vertical disc. The combination of the time of arrival of the photons with their spatial image determines not only the particle velocity, but also the wavelength of the photons. Therefore dispersion corrections on the lower and upper detection threshold is possible. Investigations concerning the development of a 3D-Barrel-DIRC are discussed as well as two different studies realizing a new Disc-DIRC for the forward angles. One is based on the Time of Propagation (ToP) method the other on the readout with focusing light guides.

  8. Energy from nuclear fission(*

    Directory of Open Access Journals (Sweden)

    Ripani M.

    2015-01-01

    Full Text Available The main features of nuclear fission as physical phenomenon will be revisited, emphasizing its peculiarities with respect to other nuclear reactions. Some basic concepts underlying the operation of nuclear reactors and the main types of reactors will be illustrated, including fast reactors, showing the most important differences among them. The nuclear cycle and radioactive-nuclear-waste production will be also discussed, along with the perspectives offered by next generation nuclear assemblies being proposed. The current situation of nuclear power in the world, its role in reducing carbon emission and the available resources will be briefly illustrated.

  9. [Chilean nuclear policy].

    Science.gov (United States)

    Bobadilla, E

    1996-06-01

    This official document is statement of the President of the Chilean Nuclear Energy Commission, Dr. Eduardo Bobadilla, about the nuclear policy of the Chilean State, Thanks to the international policy adopted by presidents Aylwin (1990-1994) and his successor Frei Ruiz Tagle (1994-), a nuclear development plan, protected by the Chilean entrance to the nuclear weapons non proliferation treaty and Tlatelolco Denuclearization treaty, has started. Chile will be able to develop without interference, an autonomous nuclear electrical system and other pacific uses of nuclear energy. Chile also supports a new international treaty to ban nuclear weapon tests.

  10. IAEA nuclear security program

    Energy Technology Data Exchange (ETDEWEB)

    Ek, D. [International Atomic Energy Agency, Vienna (Austria)

    2006-07-01

    Although nuclear security is a State responsibility, it is nevertheless an international concern, as the consequences of a nuclear security incident would have worldwide impact. These concerns have resulted in the development of numerous international instruments on nuclear security since the terrorist events in the USA on September 11, 2001. The IAEA Office of Nuclear Security has been charged to assist Member States to improvement their nuclear security and to meet the intent of these international obligations in order to ensure a cohesive thread of nuclear security protects the global community. The programs underway and planned by the Office of Nuclear Security will be discussed in this paper. (author)

  11. Some nuclear physics aspects of core-collapse supernovae

    OpenAIRE

    Qian, Yong-Zhong

    1998-01-01

    Here I review some nuclear physics aspects of core-collapse supernovae concerning neutrinos. Studies of neutrino emission and interactions in supernovae are crucial to our understanding of the explosion mechanism, the heavy element nucleosynthesis, and pulsar proper motions. I discuss the effects of reduced neutrino opacities in dense nuclear matter on supernova neutrino emission and their implications for the delayed supernova explosion mechanism and the synthesis of neutron-rich heavy eleme...

  12. Nuclear energy data 2005

    CERN Document Server

    Publishing, OECD

    2005-01-01

    This 2005 edition of Nuclear Energy Data, the OECD Nuclear Energy Agency's annual compilation of essential statistics on nuclear energy in OECD countries, offers a projection horizon lengthened to 2025 for the first time.  It presents the reader with a comprehensive overview on the status and trends in nuclear electricity generation in OECD countries and in the various sectors of the nuclear fuel cycle.

  13. Robust Optical Richness Estimation with Reduced Scatter

    Energy Technology Data Exchange (ETDEWEB)

    Rykoff, E.S.; /LBL, Berkeley; Koester, B.P.; /Chicago U. /Chicago U., KICP; Rozo, E.; /Chicago U. /Chicago U., KICP; Annis, J.; /Fermilab; Evrard, A.E.; /Michigan U. /Michigan U., MCTP; Hansen, S.M.; /Lick Observ.; Hao, J.; /Fermilab; Johnston, D.E.; /Fermilab; McKay, T.A.; /Michigan U. /Michigan U., MCTP; Wechsler, R.H.; /KIPAC, Menlo Park /SLAC

    2012-06-07

    Reducing the scatter between cluster mass and optical richness is a key goal for cluster cosmology from photometric catalogs. We consider various modifications to the red-sequence matched filter richness estimator of Rozo et al. (2009b), and evaluate their impact on the scatter in X-ray luminosity at fixed richness. Most significantly, we find that deeper luminosity cuts can reduce the recovered scatter, finding that {sigma}{sub ln L{sub X}|{lambda}} = 0.63 {+-} 0.02 for clusters with M{sub 500c} {approx}> 1.6 x 10{sup 14} h{sub 70}{sup -1} M{sub {circle_dot}}. The corresponding scatter in mass at fixed richness is {sigma}{sub ln M|{lambda}} {approx} 0.2-0.3 depending on the richness, comparable to that for total X-ray luminosity. We find that including blue galaxies in the richness estimate increases the scatter, as does weighting galaxies by their optical luminosity. We further demonstrate that our richness estimator is very robust. Specifically, the filter employed when estimating richness can be calibrated directly from the data, without requiring a-priori calibrations of the red-sequence. We also demonstrate that the recovered richness is robust to up to 50% uncertainties in the galaxy background, as well as to the choice of photometric filter employed, so long as the filters span the 4000 {angstrom} break of red-sequence galaxies. Consequently, our richness estimator can be used to compare richness estimates of different clusters, even if they do not share the same photometric data. Appendix A includes 'easy-bake' instructions for implementing our optimal richness estimator, and we are releasing an implementation of the code that works with SDSS data, as well as an augmented maxBCG catalog with the {lambda} richness measured for each cluster.

  14. Liquid-state nuclear spin comagnetometers

    CERN Document Server

    Ledbetter, Micah; Budker, Dmitry; Romalis, Michael; Blanchard, John; Pines, Alex

    2012-01-01

    We discuss nuclear spin comagnetometers based on ultra-low-field nuclear magnetic resonance in mixtures of miscible solvents, each rich in a different nuclear spin. In one version thereof, Larmor precession of protons and ${\\rm ^{19}F}$ nuclei in a mixture of thermally polarized pentane and hexafluorobenzene is monitored via a sensitive alkali-vapor magnetometer. We realize transverse relaxation times in excess of 20 s and suppression of magnetic field fluctuations by a factor of 3400. We estimate it should be possible to achieve single-shot sensitivity of about $5\\times{\\rm 10^{-9} Hz}$, or about $5\\times 10^{-11} {\\rm Hz}$ in $\\approx 1$ day of integration. In a second version, spin precession of protons and ${\\rm ^{129}Xe}$ nuclei in a mixture of pentane and hyperpolarized liquid xenon is monitored using superconducting quantum interference devices. Application to spin-gravity experiments, electric dipole moment experiments, and sensitive gyroscopes are discussed.

  15. The harmonic oscillator and nuclear physics

    Science.gov (United States)

    Rowe, D. J.

    1993-01-01

    The three-dimensional harmonic oscillator plays a central role in nuclear physics. It provides the underlying structure of the independent-particle shell model and gives rise to the dynamical group structures on which models of nuclear collective motion are based. It is shown that the three-dimensional harmonic oscillator features a rich variety of coherent states, including vibrations of the monopole, dipole, and quadrupole types, and rotations of the rigid flow, vortex flow, and irrotational flow types. Nuclear collective states exhibit all of these flows. It is also shown that the coherent state representations, which have their origins in applications to the dynamical groups of the simple harmonic oscillator, can be extended to vector coherent state representations with a much wider range of applicability. As a result, coherent state theory and vector coherent state theory become powerful tools in the application of algebraic methods in physics.

  16. Quantum nuclear pasta and nuclear symmetry energy

    Science.gov (United States)

    Fattoyev, F. J.; Horowitz, C. J.; Schuetrumpf, B.

    2017-05-01

    Complex and exotic nuclear geometries, collectively referred to as "nuclear pasta," are expected to appear naturally in dense nuclear matter found in the crusts of neutron stars and supernovae environments. The pasta geometries depend on the average baryon density, proton fraction, and temperature and are critically important in the determination of many transport properties of matter in supernovae and the crusts of neutron stars. Using a set of self-consistent microscopic nuclear energy density functionals, we present the first results of large scale quantum simulations of pasta phases at baryon densities 0.03 ≤ρ ≤0.10 fm-3 , proton fractions 0.05 ≤Yp≤0.40 , and zero temperature. The full quantum simulations, in particular, allow us to thoroughly investigate the role and impact of the nuclear symmetry energy on pasta configurations. We use the Sky3D code that solves the Skyrme Hartree-Fock equations on a three-dimensional Cartesian grid. For the nuclear interaction we use the state-of-the-art UNEDF1 parametrization, which was introduced to study largely deformed nuclei, hence is suitable for studies of the nuclear pasta. Density dependence of the nuclear symmetry energy is simulated by tuning two purely isovector observables that are insensitive to the current available experimental data. We find that a minimum total number of nucleons A =2000 is necessary to prevent the results from containing spurious shell effects and to minimize finite size effects. We find that a variety of nuclear pasta geometries are present in the neutron star crust, and the result strongly depends on the nuclear symmetry energy. The impact of the nuclear symmetry energy is less pronounced as the proton fractions increase. Quantum nuclear pasta calculations at T =0 MeV are shown to get easily trapped in metastable states, and possible remedies to avoid metastable solutions are discussed.

  17. Technology Roadmaps: Nuclear Energy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This nuclear energy roadmap has been prepared jointly by the IEA and the OECD Nuclear Energy Agency (NEA). Unlike most other low-carbon energy sources, nuclear energy is a mature technology that has been in use for more than 50 years. The latest designs for nuclear power plants build on this experience to offer enhanced safety and performance, and are ready for wider deployment over the next few years. Several countries are reactivating dormant nuclear programmes, while others are considering nuclear for the first time. China in particular is already embarking on a rapid nuclear expansion. In the longer term, there is great potential for new developments in nuclear energy technology to enhance nuclear's role in a sustainable energy future.

  18. Platelet Rich Plasma in Periodontal Therapy

    National Research Council Canada - National Science Library

    S Sathya Priya Eshwar; Dhayanand John Victor; S Sangeetha; PSG Prakash

    2017-01-01

    Keywords: Growth factors, Platelet concentrates, Platelet Rich Plasma, Regenerative medicine, Tissue engineering Introduction The goal of periodontal therapy is to improve periodontal health and thereby...

  19. Conservation and Biodiversity of Rich Fens

    DEFF Research Database (Denmark)

    Andersen, Dagmar Kappel

    2014-01-01

    Rich fen is a habitat type dependent on a constant supply of nutrient poor, calcium rich groundwater. A high, stable groundwater table, relatively high pH combined with nutrient poor conditions support a special and very species rich vegetation including many rare and threatened plant species...... of the importance of environmental conditions for the number of typical rich fen species, the species composition within a distinct taxonomic group (the mosses) and for single species (the Fen orchid, Liparis loeselii). In conclusion, especially parameters related to nutrient availability and hydrology are found...

  20. Nuclear and radiochemistry

    CERN Document Server

    Konya, Jozsef

    2012-01-01

    The field of nuclear and radiochemistry is wide-reaching, with results having functions and use across a variety of disciplines. Drawing on 40 years of experience in teaching and research, this concise book explains the basic principles and applications of the primary areas of nuclear and radiochemistry. Separate chapters cover each main area of recent radiochemistry. This includes nuclear medicine and chemical aspects of nuclear power plants, namely the problems of nuclear wastes and nuclear analysis (both bulk and surface analysis), with the analytical methods based on the interactions of

  1. Nuclear Science References Database

    Science.gov (United States)

    Pritychenko, B.; Běták, E.; Singh, B.; Totans, J.

    2014-06-01

    The Nuclear Science References (NSR) database together with its associated Web interface, is the world's only comprehensive source of easily accessible low- and intermediate-energy nuclear physics bibliographic information for more than 210,000 articles since the beginning of nuclear science. The weekly-updated NSR database provides essential support for nuclear data evaluation, compilation and research activities. The principles of the database and Web application development and maintenance are described. Examples of nuclear structure, reaction and decay applications are specifically included. The complete NSR database is freely available at the websites of the National Nuclear Data Center http://www.nndc.bnl.gov/nsr.

  2. Can shale safely host US nuclear waste?

    Science.gov (United States)

    Neuzil, C.E.

    2013-01-01

    "Even as cleanup efforts after Japan’s Fukushima disaster offer a stark reminder of the spent nuclear fuel (SNF) stored at nuclear plants worldwide, the decision in 2009 to scrap Yucca Mountain as a permanent disposal site has dimmed hope for a repository for SNF and other high-level nuclear waste (HLW) in the United States anytime soon. About 70,000 metric tons of SNF are now in pool or dry cask storage at 75 sites across the United States [Government Accountability Office, 2012], and uncertainty about its fate is hobbling future development of nuclear power, increasing costs for utilities, and creating a liability for American taxpayers [Blue Ribbon Commission on America’s Nuclear Future, 2012].However, abandoning Yucca Mountain could also result in broadening geologic options for hosting America’s nuclear waste. Shales and other argillaceous formations (mudrocks, clays, and similar clay-rich media) have been absent from the U.S. repository program. In contrast, France, Switzerland, and Belgium are now planning repositories in argillaceous formations after extensive research in underground laboratories on the safety and feasibility of such an approach [Blue Ribbon Commission on America’s Nuclear Future, 2012; Nationale Genossenschaft für die Lagerung radioaktiver Abfälle (NAGRA), 2010; Organisme national des déchets radioactifs et des matières fissiles enrichies, 2011]. Other nations, notably Japan, Canada, and the United Kingdom, are studying argillaceous formations or may consider them in their siting programs [Japan Atomic Energy Agency, 2012; Nuclear Waste Management Organization (NWMO), (2011a); Powell et al., 2010]."

  3. IRiS—Exploring new frontiers in neutron-rich isotopes of the heaviest elements with a new Inelastic Reaction Isotope Separator

    Science.gov (United States)

    Dvorak, J.; Block, M.; Düllmann, Ch. E.; Heinz, S.; Herzberg, R.-D.; Schädel, M.

    2011-10-01

    A dedicated Inelastic Reaction Isotope Separator (IRiS) for multi-nucleon transfer products will be designed and installed at GSI. Research at IRiS will focus on the investigation of new neutron-rich isotopes of the heaviest elements, study of which will advance various research fields, such as nuclear chemistry, nuclear and atomic physics, as well as nuclear astrophysics. The scientific motivation for this project and the alternative design options for the separator and its main components are discussed.

  4. Nuclear Security for Floating Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Skiba, James M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Scherer, Carolynn P. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-13

    Recently there has been a lot of interest in small modular reactors. A specific type of these small modular reactors (SMR,) are marine based power plants called floating nuclear power plants (FNPP). These FNPPs are typically built by countries with extensive knowledge of nuclear energy, such as Russia, France, China and the US. These FNPPs are built in one country and then sent to countries in need of power and/or seawater desalination. Fifteen countries have expressed interest in acquiring such power stations. Some designs for such power stations are briefly summarized. Several different avenues for cooperation in FNPP technology are proposed, including IAEA nuclear security (i.e. safeguards), multilateral or bilateral agreements, and working with Russian design that incorporates nuclear safeguards for IAEA inspections in non-nuclear weapons states

  5. Microscopic description of nuclear structure; La structure nucleaire decrite par les theories microscopiques

    Energy Technology Data Exchange (ETDEWEB)

    Girod, M.; Berger, J.F.; Peru, S.; Dancer, H. [CEA Bruyeres-le-Chatel, 91 (France)

    2002-07-01

    After briefly recalling the formalism of the mean field approach with an effective nucleon-nucleon interaction, the theoretical framework of the nuclear structure studies performed at CEA-DAM, applications of this theory to various nuclear systems: shape and spin isomeric states, neutron and proton rich nuclei, superheavy and hyper-heavy nuclei, and to the fission process are presented. (authors)

  6. Natively Unfolded FG Repeats Stabilize the Structure of the Nuclear Pore Complex

    DEFF Research Database (Denmark)

    Onischenko, Evgeny; Tang, Jeffrey H; Andersen, Kasper R

    2017-01-01

    Nuclear pore complexes (NPCs) are ∼100 MDa transport channels assembled from multiple copies of ∼30 nucleoporins (Nups). One-third of these Nups contain phenylalanine-glycine (FG)-rich repeats, forming a diffusion barrier, which is selectively permeable for nuclear transport receptors that interact...

  7. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... child is taking as well as vitamins and herbal supplements and if he or she has any ... What are the limitations of Children's (Pediatric) Nuclear Medicine? Nuclear medicine procedures can be time consuming. It ...

  8. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... MRI. top of page What are some common uses of the procedure? Children's (pediatric) nuclear medicine imaging ... at birth) or that develop during childhood. Physicians use nuclear medicine imaging to evaluate organ systems, including ...

  9. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... nuclear medicine procedures are able to pinpoint molecular activity within the body, they offer the potential to ... otherwise, your child may resume his/her normal activities after the nuclear medicine scan. If the child ...

  10. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... of page How does the nuclear medicine procedure work? With ordinary x-ray examinations, an image is ... until the nuclear physician checks the images in case additional images are needed. top of page What ...

  11. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... bones. liver and gallbladder. gastrointestinal tract. heart. lungs. brain. thyroid. Nuclear medicine scans are typically used to ... A radiologist or other physician who has specialized training in nuclear medicine will interpret the images and ...

  12. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... liver and gallbladder. gastrointestinal tract. heart. lungs. brain. thyroid. Nuclear medicine scans are typically used to help ... children. epilepsy . location, anatomy and function of the thyroid gland. top of page How does the nuclear ...

  13. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... function of the thyroid gland. top of page How does the nuclear medicine procedure work? With ordinary ... area of your child's body. top of page How is the procedure performed? Nuclear medicine imaging is ...

  14. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... usually mild. Nevertheless, you should inform the nuclear medicine personnel of any allergies your child may have or other problems that may have occurred during a previous nuclear ...

  15. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... Because nuclear medicine procedures are able to pinpoint molecular activity within the body, they offer the potential ... or imaging device that produces pictures and provides molecular information. In many centers, nuclear medicine images can ...

  16. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... of page How does the nuclear medicine procedure work? With ordinary x-ray examinations, an image is ... with other imaging techniques, such as CT or MRI. However, nuclear medicine scans are more sensitive than ...

  17. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... Tell your doctor about your child’s recent illnesses, medical conditions, medications and allergies. Depending on the type ... Nuclear Medicine? Nuclear medicine is a branch of medical imaging that uses small amounts of radioactive material ...

  18. Triangle Universities Nuclear Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    This report contains brief papers that discusses the following topics: Fundamental Symmetries in the Nucleus; Internucleon Interactions; Dynamics of Very Light Nuclei; Facets of the Nuclear Many-Body Problem; and Nuclear Instruments and Methods.

  19. Nuclear disarmament verification

    Energy Technology Data Exchange (ETDEWEB)

    DeVolpi, A.

    1993-12-31

    Arms control treaties, unilateral actions, and cooperative activities -- reflecting the defusing of East-West tensions -- are causing nuclear weapons to be disarmed and dismantled worldwide. In order to provide for future reductions and to build confidence in the permanency of this disarmament, verification procedures and technologies would play an important role. This paper outlines arms-control objectives, treaty organization, and actions that could be undertaken. For the purposes of this Workshop on Verification, nuclear disarmament has been divided into five topical subareas: Converting nuclear-weapons production complexes, Eliminating and monitoring nuclear-weapons delivery systems, Disabling and destroying nuclear warheads, Demilitarizing or non-military utilization of special nuclear materials, and Inhibiting nuclear arms in non-nuclear-weapons states. This paper concludes with an overview of potential methods for verification.

  20. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... of page What are some common uses of the procedure? Children's (pediatric) nuclear medicine imaging is performed ... the thyroid gland. top of page How does the nuclear medicine procedure work? With ordinary x-ray ...

  1. RBC nuclear scan

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003835.htm RBC nuclear scan To use the sharing features on this page, please enable JavaScript. An RBC nuclear scan uses small amounts of radioactive material to ...

  2. Nuclear fear revisited

    Science.gov (United States)

    Crease, Robert P.

    2010-10-01

    In 1988 the science historian Spencer Weart published a groundbreaking book called Nuclear Fear: A History of Images, which examined visions of radiation damage and nuclear disaster in newspapers, television, film, literature, advertisements and popular culture.

  3. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... body. jaundice in newborns and older children. epilepsy . location, anatomy and function of the thyroid gland. top ... Epilepsy Images related to Children's (Pediatric) Nuclear Medicine Videos related to Children's (Pediatric) Nuclear Medicine Sponsored by ...

  4. Guidebook to nuclear reactors

    Energy Technology Data Exchange (ETDEWEB)

    Nero, A.V. Jr.

    1976-05-01

    A general introduction to reactor physics and theory is followed by descriptions of commercial nuclear reactor types. Future directions for nuclear power are also discussed. The technical level of the material is suitable for laymen.

  5. JPRS Report, Nuclear Developments

    Science.gov (United States)

    1988-06-03

    Nuclear Power Station Projected for Jorf Lasfar [Casablanca LA VIE ECONOMIQUE , 18 Mar 88] 26 WEST EUROPE IRELAND Energy Minister Fights UK...factors mili- tate against further expansion. MOROCCO Nuclear Power Station Projected for Jorf Lasfar 51004603 Casablanca LA VIE ECONOMIQUE in...body to oversee nuclear activities at the national level and to hire and train personnel in nuclear sciences and techniques. A bill relating to the

  6. Island Species Richness Increases with Habitat Diversity

    NARCIS (Netherlands)

    Hortal, J.; Triantis, K.A.; Meiri, S.; Thebault, E.M.C.; Sfenthourakis, S.

    2009-01-01

    Species richness is commonly thought to increase with habitat diversity. However, a recent theoretical model aiming to unify niche and island biogeography theories predicted a hump-shaped relationship between richness and habitat diversity. Given the contradiction between model results and previous

  7. LHCb RICH1 Engineering Design Review Report

    CERN Document Server

    Brook, N; Metlica, F; Muir, A; Phillips, A; Buckley, A; Gibson, V; Harrison, K; Jones, C R; Katvars, S G; Lazzeroni, C; Storey, J; Ward, CP; Wotton, S; Alemi, M; Arnabaldi, C; Bellunato, T F; Calvi, M; Matteuzzi, C; Musy, M; Negri, P; Perego, D L; Pessina, G; Chamonal, R; Eisenhardt, S; Lawrence, J; McCarron, J; Muheim, F; Playfer, S; Walker, A; Cuneo, S; Fontanelli, F; Gracco, Valerio; Mini, G; Musico, P; Petrolini, A; Sannino, M; Bates, A; MacGregor, A; O'Shea, V; Parkes, C; Paterson, S; Petrie, D; Pickford, A; Rahman, M; Soler, F; Allebone, L; Barber, J H; Cameron, W; Clark, D; Dornan, Peter John; Duane, A; Egede, U; Hallam, R; Howard, A; Plackett, R; Price, D; Savidge, T; Vidal-Sitjes, G; Websdale, D M; Adinolfi, M; Bibby, J H; Cioffi, C; Gligorov, Vladimir V; Harnew, N; Harris, F; McArthur, I A; Newby, C; Ottewell, B; Rademacker, J; Senanayake, R; Somerville, L P; Soroko, A; Smale, N J; Topp-Jørgensen, S; Wilkinson, G; Yang, S; Benayoun, M; Khmelnikov, V A; Obraztsov, V F; Densham, C J; Easo, S; Franek, B; Kuznetsov, G; Loveridge, P W; Morrow, D; Morris, JV; Papanestis, A; Patrick, G N; Woodward, M L; Aglieri-Rinella, G; Albrecht, A; Braem, André; Campbell, M; D'Ambrosio, C; Forty, R W; Frei, C; Gys, Thierry; Jamet, O; Kanaya, N; Losasso, M; Moritz, M; Patel, M; Piedigrossi, D; Snoeys, W; Ullaland, O; Van Lysebetten, A; Wyllie, K

    2005-01-01

    This document describes the concepts of the engineering design to be adopted for the upstream Ring Imaging Cherenkov detector (RICH1) of the reoptimized LHCb detector. Our aim is to ensure that coherent solutions for the engineering design and integration for all components of RICH1 are available, before proceeding with the detailed design of these components.

  8. Dissociation Dynamics of Nitrogen Rich Cyclic Compounds

    Science.gov (United States)

    2010-05-17

    Arlington, VA 2220 Abstract The photophysics and photochemistry of the nitrogen-rich compounds diazomethane and diazirine were studied both...experimentally and theoretically following excitation in the ultraviolet . These molecules are locally stable on their ground potential energy surfaces, but they...ABSTRACT The photophysics and photochemistry of the nitrogen-rich compounds diazomethane and diazirine were studied both experimentally and

  9. Particle Identification with the LHCb RICH System

    CERN Document Server

    Harnew, Neville

    2005-01-01

    The LHCb experiment uses a Ring Imaging Cherenkov (RICH) system to provide particle identification over the momentum range 2-100 GeV/c. Two RICH detectors are employed. The upstream detector, RICH1, utilizes both aerogel and C$_4$F$_{10}$ gas radiators whilst the downstream RICH2 uses a CF$_4$ gas radiator. The RICH2 detector has been fabricated and is installed in the LHCb interaction region; RICH1 has a programme of phased design and construction. Novel Hybrid Photon Detectors (HPDs) have been developed in collaboration with industry to detect the Cherenkov photons in the wavelength range 200-600 nm. The HPDs are enclosed in iron shielding and Mumetal cylinders to allow operation in magnetic fields up to 50mT. The performance of pre-series HPDs and the results obtained from a particle test beam using the full LHCb readout chain is presented. The production of a total of 484 HPDs required for the two RICH detectors has recently commenced. The expected performance of the LHCb RICH system, obtained from real...

  10. NUCLEAR REACTOR CONTROL SYSTEM

    Science.gov (United States)

    Epler, E.P.; Hanauer, S.H.; Oakes, L.C.

    1959-11-01

    A control system is described for a nuclear reactor using enriched uranium fuel of the type of the swimming pool and other heterogeneous nuclear reactors. Circuits are included for automatically removing and inserting the control rods during the course of normal operation. Appropriate safety circuits close down the nuclear reactor in the event of emergency.

  11. Effects of Nuclear Weapons.

    Science.gov (United States)

    Sartori, Leo

    1983-01-01

    Fundamental principles governing nuclear explosions and their effects are discussed, including three components of a nuclear explosion (thermal radiation, shock wave, nuclear radiation). Describes how effects of these components depend on the weapon's yield, its height of burst, and distance of detonation point. Includes effects of three…

  12. Workflow in nuclear medicine.

    Science.gov (United States)

    Laet, G D; Naudts, J; Vandevivere, J

    2001-01-01

    This paper discusses a workflow management system for nuclear medicine. It augments the more conventional PACS with automatic transfer of studies along the chain of activities making up an examination in nuclear medicine. A prototype system has been designed, built, and installed in a department of nuclear medicine, active in a network of hospitals.

  13. Nuclear energy technology

    Science.gov (United States)

    Buden, David

    1992-01-01

    An overview of space nuclear energy technologies is presented. The development and characteristics of radioisotope thermoelectric generators (RTG's) and space nuclear power reactors are discussed. In addition, the policy and issues related to public safety and the use of nuclear power sources in space are addressed.

  14. Nuclear fact book

    Energy Technology Data Exchange (ETDEWEB)

    Hill, O. F.; Platt, A. M.; Robinson, J. V. [comps

    1983-05-01

    This reference provides significant highlights and summary facts in the following areas: general energy; nuclear energy; nuclear fuel cycle; uranium supply and enrichment; nuclear reactors; spent fuel and advanced repacking concepts; reprocessing; high-level waste; gaseous waste; transuranic waste; low-level waste; remedial action; transportation; disposal; radiation information; environment; legislation; socio-political aspects; conversion factors; and a glossary. (GHT)

  15. Basic Nuclear Physics.

    Science.gov (United States)

    Bureau of Naval Personnel, Washington, DC.

    Basic concepts of nuclear structures, radiation, nuclear reactions, and health physics are presented in this text, prepared for naval officers. Applications to the area of nuclear power are described in connection with pressurized water reactors, experimental boiling water reactors, homogeneous reactor experiments, and experimental breeder…

  16. Platelet-rich plasma in otolaryngology.

    Science.gov (United States)

    Stavrakas, M; Karkos, P D; Markou, K; Grigoriadis, N

    2016-12-01

    Platelet-rich plasma is a novel material that is being used more frequently in many surgical specialties. A literature review on the current and potential uses of platelet-rich plasma in otolaryngology was performed. There is limited evidence on the use of platelet-rich plasma in otolaryngology compared with other specialties: only 11 studies on various subspecialties (otology, rhinology and laryngology) were included in the final review. Based on the limited number of studies, we cannot draw safe conclusions about the value of platelet-rich plasma in otolaryngology. Nevertheless, the available literature suggests that platelet-rich plasma holds promise for future research and may have a number of clinical applications.

  17. Current status of nuclear physics research

    Energy Technology Data Exchange (ETDEWEB)

    Bertulani, Carlos A. [Department of Physics and Astronomy, Texas A and M University-Commerce (United States); Hussein, Mahir S., E-mail: hussein@if.usp.br [Instituto Tecnologico de Aeronautica (ITA), Sao Jose dos Campos, SP (Brazil). Dept. de Fisica

    2015-12-15

    In this review, we discuss the current status of research in nuclear physics which is being carried out in different centers in the world. For this purpose, we supply a short account of the development in the area which evolved over the last nine decades, since the discovery of the neutron. The evolution of the physics of the atomic nucleus went through many stages as more data became available. We briefly discuss models introduced to discern the physics behind the experimental discoveries, such as the shell model, the collective model, the statistical model, the interacting boson model, etc., some of these models may be seemingly in conflict with each other, but this was shown to be only apparent. The richness of the ideas and abundance of theoretical models attests to the important fact that the nucleus is a really singular system in the sense that it evolves from two-body bound states such as the deuteron, to few-body bound states, such as {sup 4}He, {sup 7}Li, {sup 9}Be, etc. and up the ladder to heavier bound nuclei containing up to more than 200 nucleons. Clearly, statistical mechanics, usually employed in systems with very large number of particles, would seemingly not work for such finite systems as the nuclei, neither do other theories which are applicable to condensed matter. The richness of nuclear physics stems from these restrictions. New theories and models are presently being developed. Theories of the structure and reactions of neutron-rich and proton-rich nuclei, called exotic nuclei, halo nuclei, or Borromean nuclei, deal with the wealth of experimental data that became available in the last 35 years. Furthermore, nuclear astrophysics and stellar and Big Bang nucleosynthesis have become a more mature subject. Due to limited space, this review only covers a few selected topics, mainly those with which the authors have worked on. Our aimed potential readers of this review are nuclear physicists and physicists in other areas, as well as graduate

  18. Ceres' hydrogen-rich regolith

    Science.gov (United States)

    Prettyman, Thomas H.; Yamashita, Naoyuki; Castillo-Rogez, Julie C.; Feldman, William C.; Lawrence, David J.; McSween, Harry Y.; Schorghofer, Norbert; Toplis, Michael J.; Forni, Olivier; Joy, Steven P.; Marchi, Simone; Platz, Thomas; Polanskey, Carol A.; De Sanctis, Maria Cristina; Rayman, Marc D.; Raymond, Carol A.; Russell, Christopher T.

    2016-04-01

    Low-altitude mapping of Ceres by Dawn's Gamma Ray and Neutron Detector (GRaND) began in December of 2015. GRaND will continue to acquire data for at least six months in a circular-polar orbit, at an altitude of about 0.8 body radii. Close-proximity enables global mapping of the elemental composition of Ceres' regolith, with regional-scale spatial resolution, similar to that achieved at Vesta. An initial analysis of the data shows that Ceres' regolith is rich in H, consistent with the detection of ammoniated phyllosilicates by Dawn's Visible to InfraRed (VIR) spectrometer. Global maps of neutron and gamma ray counting data reveal a strong latitude variation, with suppressed counts at the poles. Lower bound estimates of the concentration of polar H exceed that found in carbonaceous chondrites, which are the best meteorite analogs for Ceres. Thermal modeling predicts that water ice is stable near the surface at high latitudes, and, given Ceres' low obliquity, water ice and other volatile species may be concentrated in permanently shadowed regions near the poles. Excess hydrogen at high latitudes is likely in the form of water ice within the decimeter depths sensed by GRaND. Changes in the hydration state of phyllosilicates and hydrated salt minerals with temperature could also contribute to observed spatial variations. Some GRaND signatures show evidence for layering of hydrogen, consistent with ice stability models. Differences in the gamma ray spectra of Ceres and Vesta indicate that Ceres' surface is primitive (closely related to carbonaceous chondrite-like compositions), in contrast to Vesta's fractionated igneous composition. Strong gamma rays are observed at 7.6 MeV (Fe), 6.1 MeV (O), and 2.2 MeV (H). With additional accumulation time, it may be possible to quantify or bound the concentration of other elements, such as Mg, Ni, and C. Elements diagnostic of hydrothermal activity (K, Cl, and S) may be detectable if they are present in high concentrations over

  19. The electric dipole response of neutron rich tin isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Horvat, Andrea; Aumann, Thomas; Rossi, Dominic; Schindler, Fabia [Institut fuer Kernphysik, TU Darmstadt (Germany); Boretzky, Konstanze [GSI Helmholzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Johansen, Jacob [Aarhus University (Denmark); Schrock, Philipp [The University of Tokyo (Japan); Collaboration: R3B-Collaboration

    2016-07-01

    Studies of the dipole response in medium heavy and heavy neutron rich nuclei reveal valuable information about the isospin dependence of the nuclear equation of state. Therefore an experimental campaign investigating both the electric dipole response via Coulomb excitation and neutron removal along the tin isotope chain ({sup 124-134}Sn) has been carried out at the R3B (Reactions with Relativistic Radioactive Beams) setup at GSI (Helmholtzzentrum fuer Schwerionenforschung) for which the analysis is ongoing. The E1 response was induced via relativistic Coulomb scattering by a lead target in inverse kinematics, and calls for a kinematically complete determination of all reaction products in order to reconstruct the excitation energy by means of the invariant mass method. The goal is to obtain the Coulomb excitation cross section up to the adiabatic cut-off energy, covering the giant dipole resonance (GDR) range.

  20. Nuclear reactor physics

    CERN Document Server

    Stacey, Weston M

    2010-01-01

    Nuclear reactor physics is the core discipline of nuclear engineering. Nuclear reactors now account for a significant portion of the electrical power generated worldwide, and new power reactors with improved fuel cycles are being developed. At the same time, the past few decades have seen an ever-increasing number of industrial, medical, military, and research applications for nuclear reactors. The second edition of this successful comprehensive textbook and reference on basic and advanced nuclear reactor physics has been completely updated, revised and enlarged to include the latest developme

  1. Nuclear energy; Le nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This digest document was written by members of the union of associations of ex-members and retired people of the Areva group (UARGA). It gives a comprehensive overview of the nuclear industry world, starting from radioactivity and its applications, and going on with the fuel cycle (front-end, back-end, fuel reprocessing, transports), the nuclear reactors (PWR, BWR, Candu, HTR, generation 4 systems), the effluents from nuclear facilities, the nuclear wastes (processing, disposal), and the management and safety of nuclear activities. (J.S.)

  2. Nuclear parton distributions

    Directory of Open Access Journals (Sweden)

    Kulagin S. A.

    2017-01-01

    Full Text Available We review a microscopic model of the nuclear parton distribution functions, which accounts for a number of nuclear effects including Fermi motion and nuclear binding, nuclear meson-exchange currents, off-shell corrections to bound nucleon distributions and nuclear shadowing. We also discuss applications of this model to a number of processes including lepton-nucleus deep inelastic scattering, proton-nucleus Drell-Yan lepton pair production at Fermilab, as well as W± and Z0 boson production in proton-lead collisions at the LHC.

  3. History of Nuclear India

    Science.gov (United States)

    Chaturvedi, Ram

    2000-04-01

    India emerged as a free and democratic country in 1947, and entered into the nuclear age in 1948 by establishing the Atomic Energy Commission (AEC), with Homi Bhabha as the chairman. Later on the Department of Atomic Energy (DAE) was created under the Office of the Prime Minister Jawahar Lal Nehru. Initially the AEC and DAE received international cooperation, and by 1963 India had two research reactors and four nuclear power reactors. In spite of the humiliating defeat in the border war by China in 1962 and China's nuclear testing in 1964, India continued to adhere to the peaceful uses of nuclear energy. On May 18, 1974 India performed a 15 kt Peaceful Nuclear Explosion (PNE). The western powers considered it nuclear weapons proliferation and cut off all financial and technical help, even for the production of nuclear power. However, India used existing infrastructure to build nuclear power reactors and exploded both fission and fusion devices on May 11 and 13, 1998. The international community viewed the later activity as a serious road block for the Non-Proliferation Treaty and the Comprehensive Test Ban Treaty; both deemed essential to stop the spread of nuclear weapons. India considers these treaties favoring nuclear states and is prepared to sign if genuine nuclear disarmament is included as an integral part of these treaties.

  4. Sustainable nuclear energy dilemma

    Directory of Open Access Journals (Sweden)

    Afgan Naim H.

    2013-01-01

    Full Text Available Sustainable energy development implies the need for the emerging potential energy sources which are not producing adverse effect to the environment. In this respect nuclear energy has gained the complimentary favor to be considered as the potential energy source without degradation of the environment. The sustainability evaluation of the nuclear energy systems has required the special attention to the criteria for the assessment of nuclear energy system before we can make firm justification of the sustainability of nuclear energy systems. In order to demonstrate the sustainability assessment of nuclear energy system this exercise has been devoted to the potential options of nuclear energy development, namely: short term option, medium term option, long term option and classical thermal system option. Criteria with following indicators are introduced in this analysis: nuclear indicator, economic indicator, environment indicator, social indicator... The Sustainability Index is used as the merit for the priority assessment among options under consideration.

  5. Dynamic nuclear spin polarization

    Energy Technology Data Exchange (ETDEWEB)

    Stuhrmann, H.B. [GKSS-Forschungszentrum Geesthacht GmbH (Germany)

    1996-11-01

    Polarized neutron scattering from dynamic polarized targets has been applied to various hydrogenous materials at different laboratories. In situ structures of macromolecular components have been determined by nuclear spin contrast variation with an unprecedented precision. The experiments of selective nuclear spin depolarisation not only opened a new dimension to structural studies but also revealed phenomena related to propagation of nuclear spin polarization and the interplay of nuclear polarisation with the electronic spin system. The observation of electron spin label dependent nuclear spin polarisation domains by NMR and polarized neutron scattering opens a way to generalize the method of nuclear spin contrast variation and most importantly it avoids precontrasting by specific deuteration. It also likely might tell us more about the mechanism of dynamic nuclear spin polarisation. (author) 4 figs., refs.

  6. Nuclear localization signal regulates porcine circovirus type 2 capsid protein nuclear export through phosphorylation.

    Science.gov (United States)

    Hou, Qiang; Hou, Shaohua; Chen, Qing; Jia, Hong; Xin, Ting; Jiang, Yitong; Guo, Xiaoyu; Zhu, Hongfei

    2018-02-15

    The open reading frame 2 (ORF2) of Porcine circovirus type 2 (PCV2) encodes the major Capsid (Cap) protein, which self-assembles into virus-like particle (VLP) of similar morphology to the PCV2 virion and accumulates in the nucleus through the N-terminal arginine-rich nuclear localization signal (NLS). In this study, PCV2 Cap protein and its derivates were expressed via the baculovirus expression system, and the cellular localization of the recombinant proteins were investigated using anti-Cap mAb by imaging flow cytometry. Analysis of subcellular localization of Cap protein and its variants demonstrated that NLS mediated Cap protein nuclear export as well as nuclear import, and a phosphorylation site (S17) was identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the NLS domain to regulate Cap protein nuclear export. Phosphorylation of NLS regulating the PCV2 Cap protein nuclear export was also demonstrated in PK15 cells by fluorescence microscopy. Moreover, the influence of Rep and Rep' protein on Cap protein subcellular localization was investigated in PK15 cells. Phosphorylation of NLS regulating Cap protein nuclear export provides more detailed knowledge of the PCV2 viral life cycle. Copyright © 2018 Elsevier B.V. All rights reserved.

  7. Study of neutron-rich Mo isotopes by the projected shell model ...

    Indian Academy of Sciences (India)

    The neutron-rich nuclei in the mass region A∼100–110 lie far from the β-stability and thus, the prompt γ-rays from fission fragments produced by fission have been the main source to study the nuclear structure of these nuclei [11]. Hua et al [12] have extended the level schemes of 102,104,106,108Mo upto spins 16. +. , 20.

  8. snRNP proteins in health and disease

    Czech Academy of Sciences Publication Activity Database

    Krausová, Michaela; Staněk, David

    S1084-9521, č. 17 (2017), s. 30150-30157 ISSN 1084-9521 R&D Projects: GA ČR GA15-00790S; GA MŠk LO1419 Institutional support: RVO:68378050 Keywords : Congenital craniofacial disorders * Haematological malignancies * Mutations * Retinopathy * Spliceosome Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 6.614, year: 2016

  9. Firm size diversity, functional richness, and resilience

    Science.gov (United States)

    Garmestani, A.S.; Allen, Craig R.; Mittelstaedt, J.D.; Stow, C.A.; Ward, W.A.

    2006-01-01

    This paper applies recent advances in ecology to our understanding of firm development, sustainability, and economic development. The ecological literature indicates that the greater the functional richness of species in a system, the greater its resilience - that is, its ability to persist in the face of substantial changes in the environment. This paper focuses on the effects of functional richness across firm size on the ability of industries to survive in the face of economic change. Our results indicate that industries with a richness of industrial functions are more resilient to employment volatility. ?? 2006 Cambridge University Press.

  10. GALS – setup for production and study of heavy neutron rich nuclei

    Directory of Open Access Journals (Sweden)

    Zemlyanoy Sergey

    2015-01-01

    Full Text Available The present limits of the upper part of the nuclear map are very close to stability while the unexplored area of heavy neutron-rich nuclides along the neutron closed shell N = 126 below 208Pb is extremely important for nuclear astrophysics investigations and, in particular, for the understanding of the r-process of astrophysical nucleosynthesis. This area of the nuclear map can be reached neither in fusion–fission reactions nor in fragmentation processes widely used nowadays for the production of exotic nuclei. A new way was recently proposed for the production of these nuclei via low-energy multi-nucleon transfer reactions. The estimated yields of neutron-rich nuclei are found to be significantly high in such reactions and several tens of new nuclides can be produced, for example, in the near-barrier collision of 136Xe with 208Pb. A new setup is proposed to produce and study heavy neutron-rich nuclei located along the neutron closed shell N=126.

  11. GALS – setup for production and study of heavy neutron rich nuclei

    CERN Document Server

    Zemlyanoy, Sergey; Kozulin, Eduard; Kudryavtsev, Yury; Fedosseev, Valentin; Bark, Robert; Janas, Zenon; Othman, Hosam

    2015-01-01

    The present limits of the upper part of the nuclear map are very close to stability while the unexplored area of heavy neutron-rich nuclides along the neutron closed shell N = 126 below ^208Pb is extremely important for nuclear astrophysics investigations and, in particular, for the understanding of the r-process of astrophysical nucleosynthesis. This area of the nuclear map can be reached neither in fusion-fission reactions nor in fragmentation processes widely used nowadays for the production of exotic nuclei. A new way was recently proposed for the production of these nuclei via low-energy multi-nucleon transfer reactions. The estimated yields of neutron-rich nuclei are found to be significantly high in such reactions and several tens of new nuclides can be produced, for example, in the near-barrier collision of ^136Xe with ^208Pb. A new setup is proposed to produce and study heavy neutron-rich nuclei located along the neutron closed shell N=126.

  12. From nuclear structure to neutron stars

    Directory of Open Access Journals (Sweden)

    Gandolfi Stefano

    2014-03-01

    Full Text Available Recent progress in quantum Monte Carlo with modern nucleon-nucleon interactions have enabled the successful description of properties of light nuclei and neutronrich matter. As a demonstration, we show that the agreement between theoretical calculations of the charge form factor of 12C and the experimental data is excellent. Applying similar methods to isospin-asymmetric systems allows one to describe neutrons confined in an external potential and homogeneous neutron-rich matter. Of particular interest is the nuclear symmetry energy, the energy cost of creating an isospin asymmetry. Combining these advances with recent observations of neutron star masses and radii gives insight into the equation of state of neutron-rich matter near and above the saturation density. In particular, neutron star radius measurements constrain the derivative of the symmetry energy.

  13. Unexpectedly large charge radii of neutron-rich calcium isotopes

    CERN Document Server

    Garcia Ruiz, R F; Blaum, K; Ekström, A; Frömmgen, N; Hagen, G; Hammen, M; Hebeler, K; Holt, J D; Jansen, G R; Kowalska, M; Kreim, K; Nazarewicz, W; Neugart, R; Neyens, G; Nörtershäuser, W; Papenbrock, T; Papuga, J; Schwenk, A; Simonis, J; Wendt, K A; Yordanov, D T

    2016-01-01

    Despite being a complex many-body system, the atomic nucleus exhibits simple structures for certain ‘magic’ numbers of protons and neutrons. The calcium chain in particular is both unique and puzzling: evidence of doubly magic features are known in 40,48Ca, and recently suggested in two radioactive isotopes, 52,54Ca. Although many properties of experimentally known calcium isotopes have been successfully described by nuclear theory, it is still a challenge to predict the evolution of their charge radii. Here we present the first measurements of the charge radii of 49,51,52Ca, obtained from laser spectroscopy experiments at ISOLDE, CERN. The experimental results are complemented by state-of-the-art theoretical calculations. The large and unexpected increase of the size of the neutron-rich calcium isotopes beyond N = 28 challenges the doubly magic nature of 52Ca and opens new intriguing questions on the evolution of nuclear sizes away from stability, which are of importance for our understanding of neutron-...

  14. Evaluating Media Richness in Organizational Learning

    DEFF Research Database (Denmark)

    Evaluating Media Richness in Organizational Learning is an essential reference source for the latest scholarly research on the application of computational tools for knowledge management frameworks and strategies in organizations. Featuring a broad range of coverage on topics and perspectives...

  15. Nuclear energy - some aspects; Energia nuclear - alguns aspectos

    Energy Technology Data Exchange (ETDEWEB)

    Bandeira, Fausto de Paula Menezes

    2005-05-15

    This work presents a brief history of research and development concerning to nuclear technology worldwide and in Brazil, also information about radiations and radioactive elements as well; the nuclear technology applications; nuclear reactor types and functioning of thermonuclear power plants; the number of existing nuclear power plants; the nuclear hazards occurred; the national fiscalization of nuclear sector; the Brazilian legislation in effect and the propositions under proceduring at House of Representatives related to the nuclear energy.

  16. Asian Primate Species Richness Correlates with Rainfall

    OpenAIRE

    Wang, Yi-Chen; Srivathsan, Amrita; Feng, Chen-Chieh; Salim, Agus; Shekelle, Myron

    2013-01-01

    Previous studies of meta-analyses found significantly positive correlations between primate species richness and rainfall for Africa, Madagascar and the Neotropics, with the exception of Asia, leaving the open question whether that anomaly is the result of sampling bias, biogeography, or some other factor. This study re-examines the question using modelled data, with primate species richness data from the Southeast Asian Mammals Databank and rainfall data from the Climatic Research Unit. Data...

  17. Nuclear, particle and many body physics

    CERN Document Server

    Morse, Philip M; Feshbach, Herman

    2013-01-01

    Nuclear, Particle and Many Body Physics, Volume II, is the second of two volumes dedicated to the memory of physicist Amos de-Shalit. The contributions in this volume are a testament to the respect he earned as a physicist and of the warm and rich affection he commanded as a personal friend. The book contains 41 chapters and begins with a study on the renormalization of rational Lagrangians. Separate chapters cover the scattering of high energy protons by light nuclei; approximation of the dynamics of proton-neutron systems; the scattering amplitude for the Gaussian potential; Coulomb excitati

  18. Asian primate species richness correlates with rainfall.

    Science.gov (United States)

    Wang, Yi-Chen; Srivathsan, Amrita; Feng, Chen-Chieh; Salim, Agus; Shekelle, Myron

    2013-01-01

    Previous studies of meta-analyses found significantly positive correlations between primate species richness and rainfall for Africa, Madagascar and the Neotropics, with the exception of Asia, leaving the open question whether that anomaly is the result of sampling bias, biogeography, or some other factor. This study re-examines the question using modelled data, with primate species richness data from the Southeast Asian Mammals Databank and rainfall data from the Climatic Research Unit. Data processing with Geographical Information Systems resulted in 390 sample points. Reduced major axis and ordinary least squares regressions were employed to examine the relationship for six regions, including the whole study area of Southeast Asia, and the subareas of Huxley West, Huxley East, Mainland Southeast Asia, Borneo, and Sumatra. The results showed a significant positive relationship between primate species richness and mean annual rainfall for Southeast Asia (r = 0.26, Pcorrelation (r = 0.58; Pspecies richness is positively associated with mean annual rainfall in Southeast Asia. Our findings contrast to prior studies of meta-analyses that showed no relationship between rainfall and primate species richness in Asia, and thereby bring Asia into agreement with results showing significant positive correlations between rainfall and primate species richness everywhere else in the world. The inference is that previous anomalous results for Asia were result of sampling bias in the meta-analysis.

  19. Nuclear power industry

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-04-28

    This press dossier presented in Shanghai (China) in April 1999, describes first the activities of the Framatome group in the people`s republic of China with a short presentation of the Daya Bay power plant and of the future Ling Ao project, and with a description of the technological cooperation with China in the nuclear domain (technology transfers, nuclear fuels) and in other industrial domains (mechanics, oil and gas, connectors, food and agriculture, paper industry etc..). The general activities of the Framatome group in the domain of energy (nuclear realizations in France, EPR project, export activities, nuclear services, nuclear fuels, nuclear equipments, industrial equipments) and of connectors engineering are presented in a second and third part with the 1998 performances. (J.S.)

  20. Nuclear Threats and Security

    Directory of Open Access Journals (Sweden)

    Garry Jacobs

    2012-10-01

    Full Text Available This article presents highlights and insights from the International Conference on “Nuclear Threats and Security” organized by the World Academy of Art and Science in association with the European Leadership Network and the Dag Hammarskjöld University College of International Relations and Diplomacy and sponsored by NATO at the Inter-University Centre, Dubrovnik on September 14-16, 2012. The conference examined important issues related to nuclear non-proliferation and disarmament, the legality of nuclear weapons and their use, illicit trade in nuclear materials, the dangers of nuclear terrorism, nuclear- and cyber-security. Papers and video recordings of the major presentations and session summaries can be found here.

  1. Nuclear Science References Database

    Energy Technology Data Exchange (ETDEWEB)

    Pritychenko, B., E-mail: pritychenko@bnl.gov [National Nuclear Data Center, Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Běták, E. [Institute of Physics, Slovak Academy of Sciences, 84511 Bratislava (Slovakia); Singh, B. [Department of Physics and Astronomy, McMaster University, Hamilton, Ontario, Canada L8S 4M1 (Canada); Totans, J. [National Nuclear Data Center, Brookhaven National Laboratory, Upton, NY 11973-5000 (United States)

    2014-06-15

    The Nuclear Science References (NSR) database together with its associated Web interface, is the world's only comprehensive source of easily accessible low- and intermediate-energy nuclear physics bibliographic information for more than 210,000 articles since the beginning of nuclear science. The weekly-updated NSR database provides essential support for nuclear data evaluation, compilation and research activities. The principles of the database and Web application development and maintenance are described. Examples of nuclear structure, reaction and decay applications are specifically included. The complete NSR database is freely available at the websites of the National Nuclear Data Center (http://www.nndc.bnl.gov/nsr) and the International Atomic Energy Agency (http://www-nds.iaea.org/nsr)

  2. Absolute nuclear material assay

    Science.gov (United States)

    Prasad, Manoj K [Pleasanton, CA; Snyderman, Neal J [Berkeley, CA; Rowland, Mark S [Alamo, CA

    2012-05-15

    A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute nuclear material assay comprises utilizing a random sampling of analytically computed fission chain distributions to generate a continuous time-evolving sequence of event-counts by spreading the fission chain distribution in time.

  3. Financing the Nuclear Renaissance

    OpenAIRE

    NUTTALL, William J.; Taylor, S

    2008-01-01

    This paper considers the key economic risks associated with nuclear power. The authors observe that the bulk of the risks of a nuclear power station project fall during the roughly five year period of plant construction. This window of risk follows a lengthy siting process and comes before power station operations lasting up to sixty years. As a consequence of the nature of the economic risks, operational nuclear power plants are more attractive targets for initial investment than new build p...

  4. Nuclear Parity with China?

    Science.gov (United States)

    2012-01-01

    Comprehensive Nuclear-Test- Ban Treaty (CTBT) in 1996, and applied for membership in the Missile Technology Control Regime (MTCR) in 2004. Since at least the...first nuclear test ban agreements? Is the United States seeking to gain relative advantage under the guise of nuclear parity? Caroline Ziemke-Dickens...of what senior State Department officials call “doing our homework ” for future arms control negotiations, and even there is has a low standing

  5. Nuclear Fabrication Consortium

    Energy Technology Data Exchange (ETDEWEB)

    Levesque, Stephen [EWI, Columbus, OH (United States)

    2013-04-05

    This report summarizes the activities undertaken by EWI while under contract from the Department of Energy (DOE) Office of Nuclear Energy (NE) for the management and operation of the Nuclear Fabrication Consortium (NFC). The NFC was established by EWI to independently develop, evaluate, and deploy fabrication approaches and data that support the re-establishment of the U.S. nuclear industry: ensuring that the supply chain will be competitive on a global stage, enabling more cost-effective and reliable nuclear power in a carbon constrained environment. The NFC provided a forum for member original equipment manufactures (OEM), fabricators, manufacturers, and materials suppliers to effectively engage with each other and rebuild the capacity of this supply chain by : Identifying and removing impediments to the implementation of new construction and fabrication techniques and approaches for nuclear equipment, including system components and nuclear plants. Providing and facilitating detailed scientific-based studies on new approaches and technologies that will have positive impacts on the cost of building of nuclear plants. Analyzing and disseminating information about future nuclear fabrication technologies and how they could impact the North American and the International Nuclear Marketplace. Facilitating dialog and initiate alignment among fabricators, owners, trade associations, and government agencies. Supporting industry in helping to create a larger qualified nuclear supplier network. Acting as an unbiased technology resource to evaluate, develop, and demonstrate new manufacturing technologies. Creating welder and inspector training programs to help enable the necessary workforce for the upcoming construction work. Serving as a focal point for technology, policy, and politically interested parties to share ideas and concepts associated with fabrication across the nuclear industry. The report the objectives and summaries of the Nuclear Fabrication Consortium

  6. Absolute nuclear material assay

    Science.gov (United States)

    Prasad, Manoj K [Pleasanton, CA; Snyderman, Neal J [Berkeley, CA; Rowland, Mark S [Alamo, CA

    2010-07-13

    A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute nuclear material assay comprises utilizing a random sampling of analytically computed fission chain distributions to generate a continuous time-evolving sequence of event-counts by spreading the fission chain distribution in time.

  7. Decay Study for the very Neutron-Rich Sn Nuclides, $^{135-140}$Sn Separated by Selective Laser Ionization

    CERN Multimedia

    2002-01-01

    %IS378 %title\\\\ \\\\ In this investigation, we wish to take advantage of chemically selective laser ionization to separate the very-neutron-rich Sn nuclides and determine their half-lives and delayed-neutron branches (P$_{n}$) using the Mainz $^{3}$He-delayed neutron spectrometer and close-geometry $\\gamma$-ray spectroscopy system. The $\\beta$-decay rates are dependent on a number of nuclear structure factors that may not be well described by models of nuclear structure developed for nuclides near stability. Determination of these decay properties will provide direct experimental data for r-process calculations and test the large number of models of nuclear structure for very-neutron rich Sn nuclides now in print.

  8. Nuclear reactor apparatus

    Science.gov (United States)

    Wade, Elman E.

    1978-01-01

    A lifting, rotating and sealing apparatus for nuclear reactors utilizing rotating plugs above the nuclear reactor core. This apparatus permits rotation of the plugs to provide under the plug refueling of a nuclear core. It also provides a means by which positive top core holddown can be utilized. Both of these operations are accomplished by means of the apparatus lifting the top core holddown structure off the nuclear core while stationary, and maintaining this structure in its elevated position during plug rotation. During both of these operations, the interface between the rotating member and its supporting member is sealingly maintained.

  9. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... variety of diseases, including many types of cancers, heart disease, gastrointestinal, endocrine, neurological disorders and other abnormalities within the body. Because nuclear medicine procedures are ...

  10. Nuclear medicine physics

    CERN Document Server

    De Lima, Joao Jose

    2011-01-01

    Edited by a renowned international expert in the field, Nuclear Medicine Physics offers an up-to-date, state-of-the-art account of the physics behind the theoretical foundation and applications of nuclear medicine. It covers important physical aspects of the methods and instruments involved in modern nuclear medicine, along with related biological topics. The book first discusses the physics of and machines for producing radioisotopes suitable for use in conventional nuclear medicine and PET. After focusing on positron physics and the applications of positrons in medicine and biology, it descr

  11. Nuclear structure theory

    CERN Document Server

    Irvine, J M

    1972-01-01

    Nuclear Structure Theory provides a guide to nuclear structure theory. The book is comprised of 23 chapters that are organized into four parts; each part covers an aspect of nuclear structure theory. In the first part, the text discusses the experimentally observed phenomena, which nuclear structure theories need to look into and detail the information that supports those theories. The second part of the book deals with the phenomenological nucleon-nucleon potentials derived from phase shift analysis of nucleon-nucleon scattering. Part III talks about the phenomenological parameters used to de

  12. Nuclear criticality safety guide

    Energy Technology Data Exchange (ETDEWEB)

    Pruvost, N.L.; Paxton, H.C. [eds.

    1996-09-01

    This technical reference document cites information related to nuclear criticality safety principles, experience, and practice. The document also provides general guidance for criticality safety personnel and regulators.

  13. PACS in nuclear medicine

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Keon Wook [National Cancer Center, Koyang (Korea, Republic of)

    2000-12-01

    PACS (Picture Archiving and Communication System) is being rapidly spread and installed in many hospitals, but most of the system do not include nuclear medicine field. Although additional costs of hardware for nuclear medicine PACS is low, the complexity in developing viewing software and little market have made the nuclear medicine PACS not popular. Most PACS utilize DICOM 3.0 as standard format, but standard format in nuclear medicine has been Interfile. Interfile should be converted into DICOM format if nuclear images are to be stored and visualized in most PACS. Nowadays, many vendors supply the DICOM option in gamma camera and PET. Several hospitals in Korea have already installed nucler PACS with DICOM, but only the screen captured images are supplied. Software for visualizing pseudo-color with color lookup tables and expressing with volume view should be developed to fulfill the demand of referring physicians and nuclear medicine physicians. PACS is going to integrate not only radiologic images but also endoscopic and pathologic images. Web and PC based PACS is now a trend and is much compatible with nuclear medicine PACS. Most important barrier for nuclear medicine PACS that we encounter is not a technical problem, but indifference of investor such as administrator of hospital or PACS. Now it is time to support and invest for the development of nuclear medicine PACS.

  14. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... heart disease, gastrointestinal, endocrine, neurological disorders and other abnormalities within the body. Because nuclear medicine procedures are able to pinpoint molecular activity ...

  15. Nuclear envelope remnants: fluid membranes enriched in sterols and polyphosphoinositides.

    Directory of Open Access Journals (Sweden)

    Marie Garnier-Lhomme

    Full Text Available The cytoplasm of eukaryotic cells is a highly dynamic compartment where membranes readily undergo fission and fusion to reorganize the cytoplasmic architecture, and to import, export and transport various cargos within the cell. The double membrane of the nuclear envelope that surrounds the nucleus, segregates the chromosomes from cytoplasm and regulates nucleocytoplasmic transport through pores. Many details of its formation are still unclear. At fertilization the sperm devoid of nuclear envelope pores enters the egg. Although most of the sperm nuclear envelope disassembles, remnants of the envelope at the acrosomal and centriolar fossae do not and are subsequently incorporated into the newly forming male pronuclear envelope. Remnants are conserved from annelid to mammalian sperm.Using lipid mass spectrometry and a new application of deuterium solid-state NMR spectroscopy we have characterized the lipid composition and membrane dynamics of the sperm nuclear envelope remnants in isolated sperm nuclei.We report nuclear envelope remnants are relatively fluid membranes rich in sterols, devoid of sphingomyelin, and highly enriched in polyphosphoinositides and polyunsaturated phospholipids. The localization of the polybasic effector domain of MARCKS illustrates the non-nuclear aspect of the polyphosphoinositides. Based on their atypical biophysical characteristics and phospholipid composition, we suggest a possible role for nuclear envelope remnants in membrane fusion leading to nuclear envelope assembly.

  16. LITHIUM-RICH GIANTS IN GLOBULAR CLUSTERS

    Energy Technology Data Exchange (ETDEWEB)

    Kirby, Evan N.; Cohen, Judith G. [California Institute of Technology, 1200 E. California Boulevard, MC 249-17, Pasadena, CA 91125 (United States); Guhathakurta, Puragra [UCO/Lick Observatory and Department of Astronomy and Astrophysics, University of California, 1156 High Street, Santa Cruz, CA 95064 (United States); Zhang, Andrew J. [The Harker School, 500 Saratoga Avenue, San Jose, CA 95129 (United States); Hong, Jerry [Palo Alto High School, 50 Embarcadero Road, Palo Alto, CA, 94301 (United States); Guo, Michelle [Stanford University, 450 Serra Mall, Stanford, CA 94305 (United States); Guo, Rachel [Irvington High School, 41800 Blacow Road, Fremont, CA 94538 (United States); Cunha, Katia [Observatório Nacional, São Cristóvão Rio de Janeiro (Brazil)

    2016-03-10

    Although red giants deplete lithium on their surfaces, some giants are Li-rich. Intermediate-mass asymptotic giant branch (AGB) stars can generate Li through the Cameron–Fowler conveyor, but the existence of Li-rich, low-mass red giant branch (RGB) stars is puzzling. Globular clusters are the best sites to examine this phenomenon because it is straightforward to determine membership in the cluster and to identify the evolutionary state of each star. In 72 hours of Keck/DEIMOS exposures in 25 clusters, we found four Li-rich RGB and two Li-rich AGB stars. There were 1696 RGB and 125 AGB stars with measurements or upper limits consistent with normal abundances of Li. Hence, the frequency of Li-richness in globular clusters is (0.2 ± 0.1)% for the RGB, (1.6 ± 1.1)% for the AGB, and (0.3 ± 0.1)% for all giants. Because the Li-rich RGB stars are on the lower RGB, Li self-generation mechanisms proposed to occur at the luminosity function bump or He core flash cannot explain these four lower RGB stars. We propose the following origin for Li enrichment: (1) All luminous giants experience a brief phase of Li enrichment at the He core flash. (2) All post-RGB stars with binary companions on the lower RGB will engage in mass transfer. This scenario predicts that 0.1% of lower RGB stars will appear Li-rich due to mass transfer from a recently Li-enhanced companion. This frequency is at the lower end of our confidence interval.

  17. Commercial nuclear power 1990

    Energy Technology Data Exchange (ETDEWEB)

    1990-09-28

    This report presents the status at the end of 1989 and the outlook for commercial nuclear capacity and generation for all countries in the world with free market economies (FME). The report provides documentation of the US nuclear capacity and generation projections through 2030. The long-term projections of US nuclear capacity and generation are provided to the US Department of Energy's (DOE) Office of Civilian Radioactive Waste Management (OCRWM) for use in estimating nuclear waste fund revenues and to aid in planning the disposal of nuclear waste. These projections also support the Energy Information Administration's annual report, Domestic Uranium Mining and Milling Industry: Viability Assessment, and are provided to the Organization for Economic Cooperation and Development. The foreign nuclear capacity projections are used by the DOE uranium enrichment program in assessing potential markets for future enrichment contracts. The two major sections of this report discuss US and foreign commercial nuclear power. The US section (Chapters 2 and 3) deals with (1) the status of nuclear power as of the end of 1989; (2) projections of nuclear capacity and generation at 5-year intervals from 1990 through 2030; and (3) a discussion of institutional and technical issues that affect nuclear power. The nuclear capacity projections are discussed in terms of two projection periods: the intermediate term through 2010 and the long term through 2030. A No New Orders case is presented for each of the projection periods, as well as Lower Reference and Upper Reference cases. 5 figs., 30 tabs.

  18. Laser spectroscopy on neutron rich sodium isotopes

    CERN Document Server

    Huber, G; Jacquinot, P; Juncar, P; Klapisch, Robert; Liberman, S; Pinard, J; Thibault, C; Vialle, J L

    1976-01-01

    The authors describe results with single-mode dye lasers in high- resolution atomic line spectroscopy. Optical pumping and magnetic resonance detection of Na D-lines provide values of static nuclear groundstate properties.

  19. Nuclear Energy and the Environment.

    Science.gov (United States)

    International Atomic Energy Agency, Vienna (Austria).

    "Nuclear Energy and the Environment" is a pocket folder of removable leaflets concerned with two major topics: Nuclear energy and Nuclear Techniques. Under Nuclear Energy, leaflets concerning the topics of "Radiation--A Fact of Life,""The Impact of a Fact: 1963 Test Ban Treaty,""Energy Needs and Nuclear Power,""Power Reactor Safety,""Transport,"…

  20. The folding of disulfide-rich proteins.

    Science.gov (United States)

    Craik, David J

    2011-01-01

    The articles in this forum issue describe various aspects of the folding of disulfide-rich proteins. They include review articles using proteins such as bovine pancreatic trypsin inhibitor as models to highlight the range of folding pathways seen in disulfide-rich proteins, along with a detailed analysis of the methods used to study them. Following two comprehensive reviews on the methods and applications of protein folding, three original articles in this issue focus on two specific classes of disulfide-rich proteins that have applications in drug design and development, namely cyclotides and conotoxins. Cyclotides are head-to-tail cyclic and disulfide-rich proteins from plants and function as a defense against insect attack. Conotoxins are the disulfide-rich components of the venom of marine cone snails that is used to capture prey. These research articles report on factors that modulate protein folding pathways in these molecules and determine the outcomes of protein folding, that is, yield and heterogeneity of products. Finally, the issue concludes with a comprehensive review on a different type of disulfide bond, namely those that have a functional rather than structural role in proteins, with a particular focus on allosteric disulfide bonds that modify protein function.

  1. Nuclear Power Plant Technician

    Science.gov (United States)

    Randall, George A.

    1975-01-01

    The author recognizes a body of basic knowledge in nuclear power plant technoogy that can be taught in school programs, and lists the various courses, aiming to fill the anticipated need for nuclear-trained manpower--persons holding an associate degree in engineering technology. (Author/BP)

  2. JPRS Report, Nuclear Developments.

    Science.gov (United States)

    1989-09-18

    105 of them new internationally) and a determination of their characteris- tics ; it includes a uniform quantum mechanical descrip- tion of the... Empresas Nucleares Brasileiras S.A. (Nuclebras) to Industrias Nucleares do Brasil S.A. (INB), and trans- ferred the shares of its capital stock

  3. Nuclear Weapons and Schools.

    Science.gov (United States)

    Howie, David I.

    1984-01-01

    The growing debate on nuclear weapons in recent years has begun to make inroads into school curricula. Elementary and secondary school teachers now face the important task of educating their students on issues relating to nuclear war without indoctrinating them to a particular point of view. (JBM)

  4. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available Toggle navigation Test/Treatment Patient Type Screening/Wellness Disease/Condition Safety En Español More Info Images/Videos About Us News Physician Resources Professions Site Index A-Z Children's (Pediatric) Nuclear Medicine Children’s (pediatric) nuclear medicine imaging ...

  5. Nuclear-Powered Debate.

    Science.gov (United States)

    Arce, Gary

    1992-01-01

    Describes an exercise to develop interest and understanding about nuclear energy in which students make presentations regarding a proposal to build a hypothetical nuclear power plant. Students spend two weeks researching the topic; give testimony before a "Senate Energy Committee"; and vote on the proposal. Background information is…

  6. Exotic nuclear matter

    Directory of Open Access Journals (Sweden)

    Lenske H.

    2016-01-01

    Full Text Available Recent developments of nuclear structure theory for exotic nuclei are addressed. The inclusion of hyperons and nucleon resonances is discussed. Nuclear multipole response functions, hyperon interactions in infinite matter and in neutron stars and theoretical aspects of excitations of nucleon resonances in nuclei are discussed.

  7. Nuclear Energy Policy

    Science.gov (United States)

    2010-05-27

    Down by Lengthy Outages,” Nucleonics Week, April 1, 2010, p. 1. Totals are for gross generation, including electricity used for reactor operation. 5...would 7World Nuclear Performance in 2009 Pushed Down by Lengthy Outages,” Nucleonics Week... Nucleonics Week, April 15, 2010, p. 1. 12 ESBWR: Economic Simplified Boiling Water Reactor; APWR: Advanced Pressurized Water Reactor. Nuclear Energy

  8. Nuclear Power Plants. Revised.

    Science.gov (United States)

    Lyerly, Ray L.; Mitchell, Walter, III

    This publication is one of a series of information booklets for the general public published by the United States Atomic Energy Commission. Among the topics discussed are: Why Use Nuclear Power?; From Atoms to Electricity; Reactor Types; Typical Plant Design Features; The Cost of Nuclear Power; Plants in the United States; Developments in Foreign…

  9. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... radioactive energy that is emitted from the patient's body and converts it into an image. The gamma camera itself does not emit any ... View full size with caption Related Articles and Media General Nuclear ... to Children's (Pediatric) Nuclear Medicine Videos related ...

  10. Nuclear multifragmentation: Basic concepts

    Indian Academy of Sciences (India)

    2014-05-02

    May 2, 2014 ... Abstract. We present a brief overview of nuclear multifragmentation reaction. Basic formalism of canonical thermodynamical model based on equilibrium statistical mechanics is described. This model is used to calculate basic observables of nuclear multifragmentation like mass distribution, fragment ...

  11. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... medicine refers to imaging examinations done in babies, young children and teenagers. Nuclear medicine imaging procedures are noninvasive ... exams at the same time. An emerging imaging technology, but not readily available at ... procedure? Children's (pediatric) nuclear medicine imaging is performed to help ...

  12. Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.

    Science.gov (United States)

    Chen, Zhe; Gui, Bin; Zhang, Yu; Xie, Guojia; Li, Wanjin; Liu, Shumeng; Xu, Bosen; Wu, Chongyang; He, Lin; Yang, Jianguo; Yi, Xia; Yang, Xiaohan; Sun, Luyang; Liang, Jing; Shang, Yongfeng

    2017-11-03

    The de novo assembly and post-splicing reassembly of the U4/U6.U5 tri-snRNP remain to be investigated. We report here that ZIP, a protein containing a CCCH-type zinc finger and a G-patch domain, as characterized by us previously, regulates pre-mRNA splicing independent of RNA binding. We found that ZIP physically associates with the U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP). Remarkably, the ZIP-containing tri-snRNP, which has a sedimentation coefficient of ∼35S, is a tri-snRNP that has not been described previously. We also found that the 35S tri-snRNP contains hPrp24, indicative of a state in which the U4/U6 di-snRNP is integrating with the U5 snRNP. We found that the 35S tri-snRNP is enriched in the Cajal body, indicating that it is an assembly intermediate during 25S tri-snRNP maturation. We showed that the 35S tri-snRNP also contains hPrp43, in which ATPase/RNA helicase activities are stimulated by ZIP. Our study identified, for the first time, a tri-snRNP intermediate, shedding new light on the de novo assembly and recycling of the U4/U6.U5 tri-snRNP. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  13. Themes in nuclear law; Temas de Derecho Nuclear

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    The nuclear law was analyzed during a workshop. The main aspects were: the law of population to access to information on nuclear energy and the relationship between the Regulator Organism and the nuclear power plants managers.

  14. Nuclear-pumped lasers

    CERN Document Server

    Prelas, Mark

    2016-01-01

    This book focuses on Nuclear-Pumped Laser (NPL) technology and provides the reader with a fundamental understanding of NPLs, a review of research in the field, and exploration of large scale NPL system design and applications. Early chapters look at the fundamental properties of lasers, nuclear-pumping and nuclear reactions that may be used as drivers for nuclear-pumped lasers. The book goes on to explore the efficient transport of energy from the ionizing radiation to the laser medium and then the operational characteristics of existing nuclear-pumped lasers. Models based on Mathematica, explanations and a tutorial all assist the reader’s understanding of this technology. Later chapters consider the integration of the various systems involved in NPLs and the ways in which they can be used, including beyond the military agenda. As readers will discover, there are significant humanitarian applications for high energy/power lasers, such as deflecting asteroids, space propulsion, power transmission and mining....

  15. Nuclear physics today

    CERN Document Server

    Galès, Sydney

    1999-01-01

    This brief review explores the future perspectives of nuclear physics at the dawn of the next millennium, a century after the great discoveries of H. Becquerel, Marie and Pierre Curie. Nuclear physics plays an important role in the understanding of the formation of matter in the universe. Today, fundamental research is moving towards new frontiers. Challenging physics issues like the quest for the quark-gluon plasma, the structure and the dynamics of hadrons, the properties of nuclei under extreme conditions of spin, mass, temperature and/or far off stability are the main research avenues for the future. The methods and the tools developed both experimentally and theoretically to probe and understand the nucleus at the microscopic level have a broad spectrum of applications both in other fields of sciences and in our society. Specific examples related to nuclear medicine and nuclear energy will illustrate the possible impact of the applications of Nuclear Physics to our everyday life.

  16. Nuclear power economics

    Energy Technology Data Exchange (ETDEWEB)

    Emsley, Ian; Cobb, Jonathan [World Nuclear Association, London (United Kingdom)

    2017-04-15

    Many countries recognize the substantial role which nuclear power has played in providing energy security of supply, reducing import dependence and reducing greenhouse gas and polluting emissions. Nevertheless, as such considerations are far from being fully accounted for in liberalized or deregulated power markets, nuclear plants must demonstrate their viability in these markets on commercial criteria as well as their lifecycle advantages. Nuclear plants are operating more efficiently than in the past and unit operating costs are low relative to those of alternative generating technologies. The political risk facing the economic functioning of nuclear in a number of countries has increased with the imposition of nuclear-specific taxes that in some cases have deprived operators of the economic incentive to continue to operate existing plants.

  17. Latest nuclear emulsion technology

    Science.gov (United States)

    Rokujo, Hiroki; Kawahara, Hiroaki; Komatani, Ryosuke; Morishita, Misaki; Nakano, Toshiyuki; Otsuka, Naoto; Yoshimoto, Masahiro

    2017-06-01

    Nuclear emulsion is a extremely high-resolution 3D tracking detector. Since the discovery of the pion by C.F. Powell et al. in 1946, experiments with nuclear emulsions have contributed to the development of particle physics. (e.g. the OPERA collaboration reported the discovery of νμ * ντ oscillations in appearance mode in 2015) The technology of nuclear emulsion still keeps making progress. Since 2010, we have introduced a system of nuclear emulsion gel production to our laboratory in Nagoya University, and have started self-development of the new gel, instead of from the photographic film companies. Moreover, a faster automated emulsion scanning system is developed. Its scanning speed reaches 4000 cm2/h, and the load for analyzing becomes more and more lighter. In this presentation, we report the status of nuclear emulsion technologies for cosmic ray experiments.

  18. World nuclear outlook 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-29

    As part of the EIA program to provide energy information, this analysis report presents the current status and projections through 2015 of nuclear capacity, generation, and fuel cycle requirements for all countries in the world using nuclear power to generate electricity for commercial use. It also contains information and forecasts of developments in the uranium market. Long-term projections of US nuclear capacity, generation, and spent fuel discharges for two different scenarios through 2040 are developed for the Department of Energy`s Office of Civilian Radioactive Waste Management (OCRWM). In turn, the OCRWM provides partial funding for preparation of this report. The projections of uranium requirements are provided to the Organization for Economic Cooperation and Development (OECD) for preparation of the Nuclear Energy Agency/OECD report, Summary of Nuclear Power and Fuel Cycle Data in OECD Member Countries.

  19. World nuclear outlook 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-01

    As part of the EIA program to provide energy information, this analysis report presents the current status and projections through 2010 of nuclear capacity, generation, and fuel cycle requirements for all countries in the world using nuclear power to generate electricity for commercial use. It also contains information and forecasts of developments in the uranium market. Long-term projections of US nuclear capacity, generation, and spent fuel discharges for three different scenarios through 2040 are developed for the Department of Energy`s Office of Civilian Radioactive Waste Management (OCRWM). In turn, the OCRWM provides partial funding for preparation of this report. The projections of uranium requirements are provided to the Organization for Economic Cooperation and Development (OECD) for preparation of the Nuclear Energy Agency/OECD report, Summary of Nuclear Power and Fuel Cycle Data in OECD Member Countries.

  20. Fundamentals of nuclear physics

    CERN Document Server

    Takigawa, Noboru

    2017-01-01

    This book introduces the current understanding of the fundamentals of nuclear physics by referring to key experimental data and by providing a theoretical understanding of principal nuclear properties. It primarily covers the structure of nuclei at low excitation in detail. It also examines nuclear forces and decay properties. In addition to fundamentals, the book treats several new research areas such as non-relativistic as well as relativistic Hartree–Fock calculations, the synthesis of super-heavy elements, the quantum chromodynamics phase diagram, and nucleosynthesis in stars, to convey to readers the flavor of current research frontiers in nuclear physics. The authors explain semi-classical arguments and derivation of its formulae. In these ways an intuitive understanding of complex nuclear phenomena is provided. The book is aimed at graduate school students as well as junior and senior undergraduate students and postdoctoral fellows. It is also useful for researchers to update their knowledge of diver...

  1. Comprehensive nuclear materials

    CERN Document Server

    Allen, Todd; Stoller, Roger; Yamanaka, Shinsuke

    2012-01-01

    Comprehensive Nuclear Materials encapsulates a panorama of fundamental information on the vast variety of materials employed in the broad field of nuclear technology. The work addresses, in five volumes, 3,400 pages and over 120 chapter-length articles, the full panorama of historical and contemporary international research in nuclear materials, from Actinides to Zirconium alloys, from the worlds' leading scientists and engineers. It synthesizes the most pertinent research to support the selection, assessment, validation and engineering of materials in extreme nuclear environments. The work discusses the major classes of materials suitable for usage in nuclear fission, fusion reactors and high power accelerators, and for diverse functions in fuels, cladding, moderator and control materials, structural, functional, and waste materials.

  2. Nuclear war, nuclear proliferation, and their consequences

    Energy Technology Data Exchange (ETDEWEB)

    Sanruddin, A.K.

    1986-01-01

    The proceedings of a colloquium convened by the Groupe de Bellerive offers the contributions of Carl Sagan, Gabriel Garcia Marquez, Kenneth Galbraith, Pierre Trudeau, Edward Kennedy, and other eminent scientists, politicians, and strategists on the subject of the proliferation of nuclear weaponry and its potential ramifications.

  3. Nuclear Powerplant Safety: Source Terms. Nuclear Energy.

    Science.gov (United States)

    Department of Energy, Washington, DC. Nuclear Energy Office.

    There has been increased public interest in the potential effects of nuclear powerplant accidents since the Soviet reactor accident at Chernobyl. People have begun to look for more information about the amount of radioactivity that might be released into the environment as a result of such an accident. When this issue is discussed by people…

  4. The nuclear pore complex and nuclear transport.

    Science.gov (United States)

    Wente, Susan R; Rout, Michael P

    2010-10-01

    Internal membrane bound structures sequester all genetic material in eukaryotic cells. The most prominent of these structures is the nucleus, which is bounded by a double membrane termed the nuclear envelope (NE). Though this NE separates the nucleoplasm and genetic material within the nucleus from the surrounding cytoplasm, it is studded throughout with portals called nuclear pore complexes (NPCs). The NPC is a highly selective, bidirectional transporter for a tremendous range of protein and ribonucleoprotein cargoes. All the while the NPC must prevent the passage of nonspecific macromolecules, yet allow the free diffusion of water, sugars, and ions. These many types of nuclear transport are regulated at multiple stages, and the NPC carries binding sites for many of the proteins that modulate and modify the cargoes as they pass across the NE. Assembly, maintenance, and repair of the NPC must somehow occur while maintaining the integrity of the NE. Finally, the NPC appears to be an anchor for localization of many nuclear processes, including gene activation and cell cycle regulation. All these requirements demonstrate the complex design of the NPC and the integral role it plays in key cellular processes.

  5. 77 FR 76541 - Entergy Nuclear Operations, Inc.; Pilgrim Nuclear Power Station

    Science.gov (United States)

    2012-12-28

    ... Nuclear Operations, Inc.; Pilgrim Nuclear Power Station AGENCY: Nuclear Regulatory Commission. ACTION... Nuclear Operations, Inc. (the licensee), for operation of the Pilgrim Nuclear Power Station (Pilgrim... Renewal of Nuclear Plants Regarding Pilgrim Nuclear Power Station, Final Report- Appendices,'' published...

  6. US nuclear weapons policy

    Energy Technology Data Exchange (ETDEWEB)

    May, M.

    1990-12-05

    We are closing chapter one'' of the nuclear age. Whatever happens to the Soviet Union and to Europe, some of the major determinants of nuclear policy will not be what they have been for the last forty-five years. Part of the task for US nuclear weapons policy is to adapt its nuclear forces and the oganizations managing them to the present, highly uncertain, but not urgently competitive situation between the US and the Soviet Union. Containment is no longer the appropriate watchword. Stabilization in the face of uncertainty, a more complicated and politically less readily communicable goal, may come closer. A second and more difficult part of the task is to deal with what may be the greatest potential source of danger to come out of the end of the cold war: the breakup of some of the cooperative institutions that managed the nuclear threat and were created by the cold war. These cooperative institutions, principally the North Atlantic Treaty Organization (NATO), the Warsaw Pact, the US-Japan alliance, were not created specifically to manage the nuclear threat, but manage it they did. A third task for nuclear weapons policy is that of dealing with nuclear proliferation under modern conditions when the technologies needed to field effective nuclear weapons systems and their command and control apparatus are ever more widely available, and the leverage over some potential proliferators, which stemmed from superpower military support, is likely to be on the wane. This paper will make some suggestions regarding these tasks, bearing in mind that the unsettled nature of that part of the world most likely to become involved in nuclear weapons decisions today must make any suggestions tentative and the allowance for surprise more than usually important.

  7. Asian primate species richness correlates with rainfall.

    Directory of Open Access Journals (Sweden)

    Yi-Chen Wang

    Full Text Available Previous studies of meta-analyses found significantly positive correlations between primate species richness and rainfall for Africa, Madagascar and the Neotropics, with the exception of Asia, leaving the open question whether that anomaly is the result of sampling bias, biogeography, or some other factor. This study re-examines the question using modelled data, with primate species richness data from the Southeast Asian Mammals Databank and rainfall data from the Climatic Research Unit. Data processing with Geographical Information Systems resulted in 390 sample points. Reduced major axis and ordinary least squares regressions were employed to examine the relationship for six regions, including the whole study area of Southeast Asia, and the subareas of Huxley West, Huxley East, Mainland Southeast Asia, Borneo, and Sumatra. The results showed a significant positive relationship between primate species richness and mean annual rainfall for Southeast Asia (r = 0.26, P<0.001. Comparing the results for the large islands and Mainland Southeast Asia showed that Sumatra had the highest correlation (r = 0.58; P<0.05. After controlling for the major biogeographic effect associated with Huxley's Line, our results showed that primate species richness is positively associated with mean annual rainfall in Southeast Asia. Our findings contrast to prior studies of meta-analyses that showed no relationship between rainfall and primate species richness in Asia, and thereby bring Asia into agreement with results showing significant positive correlations between rainfall and primate species richness everywhere else in the world. The inference is that previous anomalous results for Asia were result of sampling bias in the meta-analysis.

  8. Masses of exotic calcium isotopes pin down nuclear forces.

    Science.gov (United States)

    Wienholtz, F; Beck, D; Blaum, K; Borgmann, Ch; Breitenfeldt, M; Cakirli, R B; George, S; Herfurth, F; Holt, J D; Kowalska, M; Kreim, S; Lunney, D; Manea, V; Menéndez, J; Neidherr, D; Rosenbusch, M; Schweikhard, L; Schwenk, A; Simonis, J; Stanja, J; Wolf, R N; Zuber, K

    2013-06-20

    The properties of exotic nuclei on the verge of existence play a fundamental part in our understanding of nuclear interactions. Exceedingly neutron-rich nuclei become sensitive to new aspects of nuclear forces. Calcium, with its doubly magic isotopes (40)Ca and (48)Ca, is an ideal test for nuclear shell evolution, from the valley of stability to the limits of existence. With a closed proton shell, the calcium isotopes mark the frontier for calculations with three-nucleon forces from chiral effective field theory. Whereas predictions for the masses of (51)Ca and (52)Ca have been validated by direct measurements, it is an open question as to how nuclear masses evolve for heavier calcium isotopes. Here we report the mass determination of the exotic calcium isotopes (53)Ca and (54)Ca, using the multi-reflection time-of-flight mass spectrometer of ISOLTRAP at CERN. The measured masses unambiguously establish a prominent shell closure at neutron number N = 32, in excellent agreement with our theoretical calculations. These results increase our understanding of neutron-rich matter and pin down the subtle components of nuclear forces that are at the forefront of theoretical developments constrained by quantum chromodynamics.

  9. 77 FR 70847 - Entergy Nuclear Indian Point 2, LLC; Entergy Nuclear Operations, Inc., Indian Point Nuclear...

    Science.gov (United States)

    2012-11-27

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Indian Point 2, LLC; Entergy Nuclear Operations, Inc., Indian Point Nuclear Generating Unit No. 2, Request for Action AGENCY: Nuclear Regulatory Commission. ACTION: Request for Action...

  10. 77 FR 8904 - Entergy Nuclear Indian Point 3, LLC.; Entergy Nuclear Operations, Inc., Indian Point Nuclear...

    Science.gov (United States)

    2012-02-15

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Indian Point 3, LLC.; Entergy Nuclear Operations, Inc., Indian Point Nuclear Generating Unit 3; Exemption 1.0 Background Entergy Nuclear Operations, Inc. (Entergy or the licensee) is the...

  11. 75 FR 39057 - Entergy Nuclear Operations, Inc.; Entergy Nuclear Vermont Yankee, LLC; Vermont Yankee Nuclear...

    Science.gov (United States)

    2010-07-07

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Operations, Inc.; Entergy Nuclear Vermont Yankee, LLC; Vermont Yankee Nuclear... CFR), Section 2.206, ``Requests for Action under this Subpart,'' the U.S. Nuclear Regulatory...

  12. 76 FR 19148 - Entergy Nuclear Operations, Inc., Entergy Nuclear Vermont Yankee, LLC, Vermont Yankee Nuclear...

    Science.gov (United States)

    2011-04-06

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Operations, Inc., Entergy Nuclear Vermont Yankee, LLC, Vermont Yankee Nuclear... (10 CFR), Section 2.206, ``Requests for Action under this Subpart,'' the U.S. Nuclear Regulatory...

  13. Fast Photon Detection for COMPASS RICH1

    CERN Document Server

    Abbon, P; Angerer, H; Apollonio, M; Birsa, R; Bordalo, P; Bradamante, F; Bressan, A; Busso, L; Chiosso, M; Ciliberti, P; Colantoni, M L; Costa, S; Dibiase, N; Dafni, T; Dalla Torre, S; Diaz, V; Duic, v; Delagnes, E; Deschamps, H; Eyrich, W; Faso, D; Ferrero, A; Finger, M; Finger, M Jr; Fischer, H; Gerassimov, S; Giorgi, M; Gobbo, B; Hagemann, R; Von Harrach, D; Heinsius, F H; Joosten, R; Ketzer, B; Königsmann, K; Kolosov, V N; Konorov, I; Kramer, D; Kunne, F; Levorato, S; Maggiora, A; Magnon, A; Mann, A; Martin, A; Menon, G; Mutter, A; Nähle, O; Neyret, D; Nerling, F; Pagano, P; Paul, S; Panebianco, S; Panzieri, D; Pesaro, G; Pizzolotto, C; Polak, J; Rebourgeard, P; Rocco, E; Robinet, F; Schiavon, P; Schill, C; Schoenmeier, P; Silva, L; Slunecka, M; Steiger, L; Sozzi, F; Sulc, M; Svec, M; Tessarotto, F; Teufel, A; Wollny, H

    2006-01-01

    The new photon detection system for COMPASS RICH-1 has been designed to cope with the demanding requests of operation at high beam intensity and at high trigger rates. The detection technique in the central region of RICH-1 has been changed with a system based on multianode photomultipliers coupled to individual fused silica lens telescopes and to a fast, almost dead time free readout system based on the MAD-4 amplifier-discriminator and the F1 TDC-chip. The new photon detection system design and construction are described, as well as its first response in the experiment.

  14. Radiological Effects of Nuclear War.

    Science.gov (United States)

    Shapiro, Charles S.

    1988-01-01

    Described are the global effects of nuclear war. Discussed are radiation dosages, limited nuclear attacks, strategic arms reductions, and other results reported at the workshop on nuclear war issues in Moscow in March 1988. (CW)

  15. Your Radiologist Explains Nuclear Medicine

    Medline Plus

    Full Text Available ... by Image/Video Gallery Your Radiologist Explains Nuclear Medicine Transcript Welcome to Radiology Info dot org Hello! ... d like to talk to you about nuclear medicine. Nuclear medicine offers the potential to identify disease ...

  16. Your Radiologist Explains Nuclear Medicine

    Medline Plus

    Full Text Available ... Sponsored by Image/Video Gallery Your Radiologist Explains Nuclear Medicine Transcript Welcome to Radiology Info dot org ... I’d like to talk to you about nuclear medicine. Nuclear medicine offers the potential to identify ...

  17. Sigma: Web Retrieval Interface for Nuclear Reaction Data

    Energy Technology Data Exchange (ETDEWEB)

    Pritychenko,B.; Sonzogni, A.A.

    2008-06-24

    The authors present Sigma, a Web-rich application which provides user-friendly access in processing and plotting of the evaluated and experimental nuclear reaction data stored in the ENDF-6 and EXFOR formats. The main interface includes browsing using a periodic table and a directory tree, basic and advanced search capabilities, interactive plots of cross sections, angular distributions and spectra, comparisons between evaluated and experimental data, computations between different cross section sets. Interactive energy-angle, neutron cross section uncertainties plots and visualization of covariance matrices are under development. Sigma is publicly available at the National Nuclear Data Center website at www.nndc.bnl.gov/sigma.

  18. A comprehensive survey of nuclear reactions; Panorama des reactions nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Cugnon, J. [Liege Univ., IFPA, AGO Dept. (Belgium)

    2007-07-01

    The various mechanisms of nuclear reactions are surveyed and classified in different regimes, based on the notions of coherent mechanisms and hard versus soft processes. The emphasis is put on the concepts at the basis of the understanding of these regimes and on the elements of nuclear structure which are involved in these different regimes, as well as the on the possibility of extracting this information. Due to lack of space and for pedagogical reasons, the discussion is limited to nucleon-induced and light-ion-induced reactions. However, a few remarks are given concerning some specific probes, such as weakly bound projectiles or neutron-rich nuclei. (author)

  19. A G-rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing.

    Science.gov (United States)

    Fisette, Jean-François; Montagna, Daniel R; Mihailescu, Mihaela-Rita; Wolfe, Michael S

    2012-06-01

    β-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the transmembrane aspartyl protease that catalyzes the first cleavage step in the proteolysis of the APP to the amyloid β-protein (Aβ), a process involved in the pathogenesis of Alzheimer disease. BACE1 pre-mRNA undergoes complex alternative splicing, the regulation of which is not well understood. We identified a G-rich sequence within exon 3 of BACE1 involved in controlling splice site selection. Mutation of the G-rich sequence decreased use of the normal 5' splice site of exon 3, which leads to full-length and proteolytically active BACE1, and increased use of an alternative splice site, which leads to a shorter, essentially inactive isoform. Nuclease protection assays, nuclear magnetic resonance, and circular dichroism spectroscopy revealed that this sequence folds into a G-quadruplex structure. Several proteins were identified as capable of binding to the G-rich sequence, and one of these, heterogeneous nuclear ribonucleoprotein H, was found to regulate BACE1 exon 3 alternative splicing and in a manner dependent on the G-rich sequence. Knockdown of heterogeneous nuclear ribonucleoprotein H led to a decrease in the full-length BACE1 mRNA isoform as well as a decrease in Aβ production from APP, suggesting new possibilities for therapeutic approaches to Alzheimer's disease. © 2012 The Authors. Journal of Neurochemistry © 2012 International Society for Neurochemistry.

  20. Anti-fibrotic potential of aMatthiola arabicaisothiocyanates rich fraction: impact on oxidative stress, inflammatory and fibrosis markers.

    Science.gov (United States)

    Mohammed, E D; El-Naga, R N; Lotfy, R A; Al-Gendy, A A; El-Demerdash, E

    2017-10-01

    The present study is the first one to investigate the glucosinolates (GLS) profile and anti-fibrotic effect of isothiocyanates (ITCs) rich fraction of Matthiola arabica (Brassicaceae) using an experimental model of liver fibrosis in rats. Five GLS (ethyl glucosinolate, gluconapin, glucodehydroerucin, glucoerucin and glucoraphanin) were identified by gas liquid chromatography-mass spectrometric (GLC-MS) analysis of their hydrolysis products, produced by the natural autolysis and exogenous myrosinase hydrolysis using one and two units of the enzyme. Spectrophotometric determination of the total intact GLS revealed that content in the fresh sample was 1.8 times higher than in the dry one. ITCs rich fraction was prepared by natural autolysis of the fresh aerial part. Male albino rats were given carbon tetrachloride (CCl4) (0.5 ml/kg, twice a week) and/or ITCs -rich fraction (30 mg/ kg, three times a week) for six weeks. Liver function, different oxidative stress, inflammatory and fibrosis markers were investigated. Treatment of animals with ITCs rich fraction significantly counteracted the changes in liver function induced by CCl4. Histopathological examination under both light and electron microscope showed the anti-fibrotic effect of ITCs rich fraction. This finding was confirmed with the markedly improved liver fibrosis markers with ITCs rich fraction co-treatment. In elucidation of anti-fibrotic mechanisms of ITCs rich fraction, the significant glutathione depletion and lipid peroxidation caused by CCl4 intoxication was restored by ITCs rich fraction co-treatment. Besides, ITCs rich fraction showed an anti-inflammatory effect through its ability to counteract the significant increase in nuclear factor kappa B (NF-κB), cyclooxygenase-2 (COX-2) expression, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) levels in liver tissue that caused by CCl4 intoxication. These findings indicate that ITCs-rich fraction of M. arabica possesses a promising anti

  1. Nuclear Material Management Abstract

    Energy Technology Data Exchange (ETDEWEB)

    Jesse C. Schreiber

    2007-07-10

    Nevada Test Site (NTS) has transitioned from its historical and critical role of weapons testing to another critical role for the nation. This new role focuses on being a integral element in solving the multiple challenges facing the National Nuclear Security Administration (NNSA) with nuclear material management. NTS is positioned to be a solution for other NNSA sites challenged with safe nuclear materials storage and disposition. NNSA, with site involvement, is currently transforming the nuclear stockpile and supporting infrastructure to meet the 2030 vision. Efforts are under way to consolidate and modernize the production complex . With respect to the nuclear material stockpile, the NNSA sites are currently reducing the complex nuclear material inventory through disposition and consolidation. This includes moving material from other sites to NTS. State of the art nuclear material management and control practices at NTS are essential for NTS to ensure that assigned activities are accomplished in a safe, secure, efficient, and environmentally responsible manner. NTS activities and challenges will be addressed.

  2. Advances in nuclear physics

    CERN Document Server

    Vogt, Erich

    1975-01-01

    Review articles on three topics of considerable current interest make up the present volume. The first, on A-hypernuclei, was solicited by the editors in order to provide nuclear physicists with a general description of the most recent developments in a field which this audience has largely neglected or, perhaps, viewed as a novelty in which a bizarre nuclear system gave some information about the lambda-nuclear intersection. That view was never valid. The very recent developments reviewed here-particularly those pertaining to hypernuclear excitations and the strangeness exchange reactions-emphasize that this field provides important information about the models and central ideas of nuclear physics. The off-shell behavior of the nucleon-nucleon interaction is a topic which was at first received with some embarrassment, abuse, and neglect, but it has recently gained proper attention in many nuclear problems. Interest was first focused on it in nuclear many-body theory, but it threatened nuclear physicists'comf...

  3. Evaluated Nuclear Data

    Energy Technology Data Exchange (ETDEWEB)

    Oblozinsky, P.; Oblozinsky,P.; Herman,M.; Mughabghab,S.F.

    2010-10-01

    This chapter describes the current status of evaluated nuclear data for nuclear technology applications. We start with evaluation procedures for neutron-induced reactions focusing on incident energies from the thermal energy up to 20 MeV, though higher energies are also mentioned. This is followed by examining the status of evaluated neutron data for actinides that play dominant role in most of the applications, followed by coolants/moderators, structural materials and fission products. We then discuss neutron covariance data that characterize uncertainties and correlations. We explain how modern nuclear evaluated data libraries are validated against an extensive set of integral benchmark experiments. Afterwards, we briefly examine other data of importance for nuclear technology, including fission yields, thermal neutron scattering and decay data. A description of three major evaluated nuclear data libraries is provided, including the latest version of the US library ENDF/B-VII.0, European JEFF-3.1 and Japanese JENDL-3.3. A brief introduction is made to current web retrieval systems that allow easy access to a vast amount of up-to-date evaluated nuclear data for nuclear technology applications.

  4. Nuclear forensics: Soil content

    Energy Technology Data Exchange (ETDEWEB)

    Beebe, Merilyn Amy [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-08-31

    Nuclear Forensics is a growing field that is concerned with all stages of the process of creating and detonating a nuclear weapon. The main goal is to prevent nuclear attack by locating and securing nuclear material before it can be used in an aggressive manner. This stage of the process is mostly paperwork; laws, regulations, treaties, and declarations made by individual countries or by the UN Security Council. There is some preliminary leg work done in the form of field testing detection equipment and tracking down orphan materials; however, none of these have yielded any spectacular or useful results. In the event of a nuclear attack, the first step is to analyze the post detonation debris to aid in the identification of the responsible party. This aspect of the nuclear forensics process, while reactive in nature, is more scientific. A rock sample taken from the detonation site can be dissolved into liquid form and analyzed to determine its chemical composition. The chemical analysis of spent nuclear material can provide valuable information if properly processed and analyzed. In order to accurately evaluate the results, scientists require information on the natural occurring elements in the detonation zone. From this information, scientists can determine what percentage of the element originated in the bomb itself rather than the environment. To this end, element concentrations in soils from sixty-nine different cities are given, along with activity concentrations for uranium, thorium, potassium, and radium in various building materials. These data are used in the analysis program Python.

  5. Nuclear movement in fungi.

    Science.gov (United States)

    Xiang, Xin

    2017-12-11

    Nuclear movement within a cell occurs in a variety of eukaryotic organisms including yeasts and filamentous fungi. Fungal molecular genetic studies identified the minus-end-directed microtubule motor cytoplasmic dynein as a critical protein for nuclear movement or orientation of the mitotic spindle contained in the nucleus. Studies in the budding yeast first indicated that dynein anchored at the cortex via its anchoring protein Num1 exerts pulling force on an astral microtubule to orient the anaphase spindle across the mother-daughter axis before nuclear division. Prior to anaphase, myosin V interacts with the plus end of an astral microtubule via Kar9-Bim1/EB1 and pulls the plus end along the actin cables to move the nucleus/spindle close to the bud neck. In addition, pushing or pulling forces generated from cortex-linked polymerization or depolymerization of microtubules drive nuclear movements in yeasts and possibly also in filamentous fungi. In filamentous fungi, multiple nuclei within a hyphal segment undergo dynein-dependent back-and-forth movements and their positioning is also influenced by cytoplasmic streaming toward the hyphal tip. In addition, nuclear movement occurs at various stages of fungal development and fungal infection of plant tissues. This review discusses our current understanding on the mechanisms of nuclear movement in fungal organisms, the importance of nuclear positioning and the regulatory strategies that ensure the proper positioning of nucleus/spindle. Published by Elsevier Ltd.

  6. Virtual nuclear weapons

    Energy Technology Data Exchange (ETDEWEB)

    Pilat, J.F.

    1997-08-01

    The term virtual nuclear weapons proliferation and arsenals, as opposed to actual weapons and arsenals, has entered in recent years the American lexicon of nuclear strategy, arms control, and nonproliferation. While the term seems to have an intuitive appeal, largely due to its cyberspace imagery, its current use is still vague and loose. The author believes, however, that if the term is clearly delineated, it might offer a promising approach to conceptualizing certain current problems of proliferation. The first use is in a reference to an old problem that has resurfaced recently: the problem of growing availability of weapon-usable nuclear materials in civilian nuclear programs along with materials made `excess` to defense needs by current arms reduction and dismantlement. It is argued that the availability of these vast materials, either by declared nuclear-weapon states or by technologically advanced nonweapon states, makes it possible for those states to rapidly assemble and deploy nuclear weapons. The second use has quite a different set of connotations. It is derived conceptually from the imagery of computer-generated reality. In this use, one thinks of virtual proliferation and arsenals not in terms of the physical hardware required to make the bomb but rather in terms of the knowledge/experience required to design, assemble, and deploy the arsenal. Virtual weapons are a physics reality and cannot be ignored in a world where knowledge, experience, materials, and other requirements to make nuclear weapons are widespread, and where dramatic army reductions and, in some cases, disarmament are realities. These concepts are useful in defining a continuum of virtual capabilities, ranging from those at the low end that derive from general technology diffusion and the existence of nuclear energy programs to those at the high end that involve conscious decisions to develop or maintain militarily significant nuclear-weapon capabilities.

  7. Control of nuclear organization by F-actin binding proteins.

    Science.gov (United States)

    Pfisterer, Karin; Jayo, Asier; Parsons, Maddy

    2017-03-04

    The regulation of nuclear shape and deformability is a key factor in controlling diverse events from embryonic development to cancer cell metastasis, but the mechanisms governing this process are still unclear. Our recent study demonstrated an unexpected role for the F-actin bundling protein fascin in controlling nuclear plasticity through a direct interaction with Nesprin-2. Nesprin-2 is a component of the LINC complex that is known to couple the F-actin cytoskeleton to the nuclear envelope. We demonstrated that fascin, which is predominantly associated with peripheral F-actin rich filopodia, binds directly to Nesprin-2 at the nuclear envelope in a range of cell types. Depleting fascin or specifically blocking the fascin-Nesprin-2 complex leads to defects in nuclear polarization, movement and cell invasion. These studies reveal a novel role for an F-actin bundling protein in control of nuclear plasticity and underline the importance of defining nuclear-associated roles for F-actin binding proteins in future.

  8. Nuclear Physics Department annual report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    This annual report presents articles and abstracts published in foreign journals, covering the following subjects: nuclear structure, nuclear reactions, applied physics, instrumentation, nonlinear phenomena and high energy physics

  9. Nuclear manpower training

    Energy Technology Data Exchange (ETDEWEB)

    Suh, In Suk; Lee, H. Y.; Joe, B. J.; Lee, S. H.; Lee, E. J.; Yoo, B. H.; Seo, K. W.; Lee, W. K.; Jun, H. I.; Yang, K. N.; Kim, Y. J.; Kim, I. H.; Kim, M. Y.; Ju, Y. C.; Hyun, H. Y.; Choi, I. G.; Hong, C. S.; Won, J. Y.; Nam, J. Y.; Lee, H. J.

    1997-01-01

    This report describes the annual results of training courses. the scope and contents are as follows: 1. Regional and interregional training courses 2. Training courses assisted by foreign experts 3. Training courses for nuclear industry personnel 4. Training courses for internal staff-members 5. Training courses under the law. This Nuclear Training Center executed the open-door training courses for 2,400 engineers/scientists from the regulatory body, nuclear industries, research institutes and other related organizations by means of offering 51 training courses during the fiscal year 1996. (author). 23 refs.

  10. Nuclear Regulatory Commission issuances

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    This document is the March 1996 listing of NRC issuances. Included are: (1) NRC orders granting Cleveland Electric Illuminating Company`s petition for review of the ASLB order LBP-95-17, (2) NRC orders relating to the potential disqualification of two commissioners in the matter of the decommissioning of Yankee Nuclear Power Station, (3) ASLB orders pertaining to the Oncology Services Corporation, (4) ASLB orders pertaining to the Radiation Oncology Center, (5) ASLB orders pertaining to the Yankee Nuclear Power Station, and (6) Director`s decision pertaining to the Yankee Nuclear Power Station.

  11. Practical nuclear medicine

    CERN Document Server

    Gemmell, Howard G; Sharp, Peter F

    2006-01-01

    Nuclear medicine plays a crucial role in patient care, and this book is an essential guide for all practitioners to the many techniques that inform clinical management. The first part covers the scientific basis of nuclear medicine, the rest of the book deals with clinical applications. Diagnostic imaging has an increasingly important role in patient management and, despite advances in other modalities (functional MRI and spiral CT), nuclear medicine continues to make its unique contribution by its ability to demonstrate physiological function. This book is also expanded by covering areas of d

  12. Nuclear engineering vocabulary

    Energy Technology Data Exchange (ETDEWEB)

    Dumont, X. [FRAMATOME, Dept. Corporate R and D, 92 - Paris-La-Defence (France); Andrieux, C. [CEA Saclay, Direction des Technologies de l' Information, DTI, 91 - Gif sur Yvette (France)

    2001-07-01

    The members of the CSTNIN - the Special Commission for Nuclear Engineering Terminology and Neology - have just produced a Nuclear Engineering Vocabulary, published by SFEN. A 120-page document which, to date, includes 400 nuclear engineering terms or expressions. For each term or expression, this Glossary gives: the primary and secondary subject field in which it is applied, a possible abbreviation, its definition, a synonym if appropriate, any relevant comments, any associated word(s), the English equivalent, its status on the date of publication of the Glossary. (author)

  13. Nuclear shell theory

    CERN Document Server

    de-Shalit, Amos; Massey, H S W

    1963-01-01

    Nuclear Shell Theory is a comprehensive textbook dealing with modern methods of the nuclear shell model. This book deals with the mathematical theory of a system of Fermions in a central field. It is divided into three parts. Part I discusses the single particle shell model. The second part focuses on the tensor algebra, two-particle systems. The last part covers three or more particle systems. Chapters on wave functions in a central field, tensor fields, and the m-Scheme are also presented. Physicists, graduate students, and teachers of nuclear physics will find the book invaluable.

  14. Nuclear regulation and safety

    Energy Technology Data Exchange (ETDEWEB)

    Hendrie, J.M.

    1982-01-01

    Nuclear regulation and safety are discussed from the standpoint of a hypothetical country that is in the process of introducing a nuclear power industry and setting up a regulatory system. The national policy is assumed to be in favor of nuclear power. The regulators will have responsibility for economic, reliable electric production as well as for safety. Reactor safety is divided into three parts: shut it down, keep it covered, take out the afterheat. Emergency plans also have to be provided. Ways of keeping the core covered with water are discussed. (DLC)

  15. Mean nuclear volume

    DEFF Research Database (Denmark)

    Mogensen, O.; Sørensen, Flemming Brandt; Bichel, P.

    1999-01-01

    We evaluated the following nine parameters with respect to their prognostic value in females with endometrial cancer: four stereologic parameters [mean nuclear volume (MNV), nuclear volume fraction, nuclear index and mitotic index], the immunohistochemical expression of cancer antigen (CA125...... (range 5.0-8.4 years). Cox regression analysis (automatic forward selection) showed the MNV to be the most significant prognostic parameter followed by the P-stage. Patients who had localized tumors or tumors with small nuclei had a better probability of surviving than did women with advanced tumors...

  16. New nuclear power sources

    Science.gov (United States)

    Nuclear electric-power generation sources for the future include two viable candidates as viewed now: the fast breeder and the nuclear fusion reactors. Breeder reactors, which produce more radioactive fuels than they consume, are in the realm of existing technology. They are also categorized as potentially most harmful to the environment. Nuclear fusion reactors, on the other hand, will not be available in this century, based on current levels of development. However, they will be categorized as inherently much safer and thus potentially least harmful to the environment of all fueled electric-power generators.

  17. Nuclear expansion with excitation

    Energy Technology Data Exchange (ETDEWEB)

    De, J.N. [Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064 (India); Departament d' Estructura i Constituents de la Materia, Facultat de Fisica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona (Spain); Samaddar, S.K. [Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064 (India); Vinas, X. [Departament d' Estructura i Constituents de la Materia, Facultat de Fisica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona (Spain); Centelles, M. [Departament d' Estructura i Constituents de la Materia, Facultat de Fisica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona (Spain)]. E-mail: mario@ecm.ub.es

    2006-07-06

    The expansion of an isolated hot spherical nucleus with excitation energy and its caloric curve are studied in a thermodynamic model with the SkM{sup *} force as the nuclear effective two-body interaction. The calted results are shown to compare well with the recent experimental data from energetic nuclear collisions. The fluctuations in temperature and density are also studied. They are seen to build up very rapidly beyond an excitation energy of {approx}9 MeV/u. Volume-conserving quadrupole deformation in addition to expansion indicates, however, nuclear disassembly above an excitation energy of {approx}4 MeV/u.

  18. Monitoring international nuclear activity

    Energy Technology Data Exchange (ETDEWEB)

    Firestone, R.B.

    2006-05-19

    The LBNL Table of Isotopes website provides primary nuclearinformation to>150,000 different users annually. We have developedthe covert technology to identify users by IP address and country todetermine the kinds of nuclear information they are retrieving. Wepropose to develop pattern recognition software to provide an earlywarning system to identify Unusual nuclear activity by country or regionSpecific nuclear/radioactive material interests We have monitored nuclearinformation for over two years and provide this information to the FBIand LLNL. Intelligence is gleaned from the website log files. Thisproposal would expand our reporting capabilities.

  19. Theoretical nuclear physics

    CERN Document Server

    Blatt, John M

    1979-01-01

    A classic work by two leading physicists and scientific educators endures as an uncommonly clear and cogent investigation and correlation of key aspects of theoretical nuclear physics. It is probably the most widely adopted book on the subject. The authors approach the subject as ""the theoretical concepts, methods, and considerations which have been devised in order to interpret the experimental material and to advance our ability to predict and control nuclear phenomena.""The present volume does not pretend to cover all aspects of theoretical nuclear physics. Its coverage is restricted to

  20. Nuclear manpower training

    Energy Technology Data Exchange (ETDEWEB)

    Suh, In Suk; Lee, H. Y.; Lee, E. J.; Yang, K. N.; Jun, H. R.; Seo, K. W.; Lee, S. H.; Kim, Y. J.; Kim, I. H.; Joe, B. J.; Koh, Y. S.; Yoo, B. H.; Kim, M. Y.; Ju, Y. C.; Hyun, H. U.; Choi, I. K.; Hong, C. S.; Won, J. Y.; Nam, J. Y.; Lee, H. J

    1997-12-01

    This report describes the annual results of training courses. The scope and contents are as follows: 1. Education program development of nuclear field 2. International training courses for foreigners 3. Training courses for industry personnel 4. Training courses for R and D staff-members 5. Training courses under the law. The nuclear training center executed 65 training courses for 2,700 engineers/ scientists from the regulatory body, nuclear industries, research institutes and other related organizations during the fiscal year 1997. (author). 18 refs., 3 tabs.

  1. Nuclear physics of stars

    CERN Document Server

    Iliadis, Christian

    2015-01-01

    Most elements are synthesized, or ""cooked"", by thermonuclear reactions in stars. The newly formed elements are released into the interstellar medium during a star's lifetime, and are subsequently incorporated into a new generation of stars, into the planets that form around the stars, and into the life forms that originate on the planets. Moreover, the energy we depend on for life originates from nuclear reactions that occur at the center of the Sun. Synthesis of the elements and nuclear energy production in stars are the topics of nuclear astrophysics, which is the subject of this book

  2. Fictions of nuclear disaster

    Energy Technology Data Exchange (ETDEWEB)

    Dowling, D.

    1987-01-01

    This work is critical study of literary interpretations of the nuclear holocaust. The author examines more than 250 stories and novels dealing with the theme of nuclear power and its devastating potential implications. Addressing such topics as the scientist and Armageddon, the role of religion, future evolution and mutation, and the postnuclear society, the author assesses the response of Bradbury, Lessing, Malamud, Shute, Huxley, Vonnegut, Heinlein, and others to the threat of nuclear apocalypse, with in-depth analyses of Alter Miller's A canticle for Leibowitz and Russell Hoban's Riddley Walker.

  3. Spallation RI beam facility and heavy element nuclear chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Nagame, Yuichiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-11-01

    An outline of the spallation RI (Radioactive Ion) beam facility is presented. Neutron-rich nuclides are produced in the reaction of high intensity (10-1000 {mu}A) protons with energy of 1.5 GeV and an uranium carbide target. Produced nuclides are ionized in an isotope separator on-line (ISOL) and accelerated by the JAERI tandem and the booster linac. Current progress and a future project on the development of the RI beam facility are given. Studies of transactinide elements, including the synthesis of superheavy elements, nuclear structure far from stability, and RI-probed material science are planned with RI beams. An outlook of the transactinide nuclear chemistry studies using neutron-rich RI beams is described. (author)

  4. Technology-Rich Schools Up Close

    Science.gov (United States)

    Levin, Barbara B.; Schrum, Lynne

    2013-01-01

    This article observes that schools that use technology well have key commonalities, including a project-based curriculum and supportive, distributed leadership. The authors' research into tech-rich schools revealed that schools used three strategies to integrate technology successfully. They did so by establishing the vision and culture,…

  5. Novel Photon Detectors for RICH Applications

    Energy Technology Data Exchange (ETDEWEB)

    Va' vra, Jaroslav

    2003-01-08

    The paper describes recent developments in Photon Detectors useful for the Cherenkov Ring Imaging Applications (RICH). We discuss the Multi-anode PMTs, HPDs with PIN and APD diode readout, APDs working in a Geiger mode, and the gaseous multi-pattern detectors. The paper emphasizes their timing properties. We give equal chance to fragile, not yet entirely proven ideas.

  6. How countries become rich and reduce poverty

    DEFF Research Database (Denmark)

    Whitfield, Lindsay

    2012-01-01

    For the sake of less developed countries, it is time to adjust the discussion of international development assistance on poverty reduction. This article attempts to do so by reviewing new and old literature explaining why some countries are rich and others are poor. History has repeatedly shown...

  7. Origin of the latitudinal richness gradient

    DEFF Research Database (Denmark)

    Engemann, Kristine; Sandel, Brody Steven; Enquist, Brian J.

    2015-01-01

    Spatial variation in richness patterns must be due to variation in rates of speciation, extinction, immigration and emigration. Hotspots of diversity can occur either because they are hotspots of speciation (cradles) or cold spots of extinction (museums) – two major hypotheses that make contrasti...

  8. Species richness, area and climate correlates

    DEFF Research Database (Denmark)

    Nogues, David Bravo; Bastos Araujo, Miguel

    2006-01-01

    . The assumption is that variation in grid cell size accrued from working in a three-dimensional world is negligible. Here we provide a first test of this idea. We measure the surface area of c. 50 × 50 km and c. 220 × 220 km grid cells across western Europe. We then ask how variation in the area of grid cells...... affects: (1) the selection of climate variables entering a species richness model; and (2) the accuracy of models in predicting species richness in unsampled grid cells. Location Western Europe. Methods Models are developed for European plant, breeding bird, mammal and herptile species richness using...... seven climate variables. Generalized additive models are used to relate species richness, climate and area. Results We found that variation in the grid cell area was large (50 × 50 km: 8-3311 km2; 220 × 220: 193-55,100 km2), but this did not affect the selection of variables in the models. Similarly...

  9. First performances of COMPASS RICH-1

    CERN Document Server

    Albrecht, E; Bellunato, T F; Birsa, R; Bradamante, Franco; Bressan, A; Chapiro, A; Cicuttin, A; Colavita, A A; Costa, S; Crespo, M; Cristaudo, P; D'Ambrosio, C; Dalla Torre, S; Díaz, V; Duarte-Pinto, S; Duic, V; Fabro, M; Fauland, P; Finger, Miroslav H; Fratnik, F; Giorgi, M; Gobbo, B; Lamanna, M; Martin, A; Pagano, P; Piedigrossi, D; Schiavon, Paolo; Tessarotto, F

    2004-01-01

    COMPASS RICH-1, designed in 1996 for hadron identification at high momenta in the COMPASS large angle spectrometer, is based on the use of MWPCs with large size CsI photon detectors. This choice, dictated by technical and economical considerations, has imposed VUV requirements for mirror reflectance and radiator transparency. The detector is now fully operative and its preliminary performances are presented.

  10. Development of lichen-rich communities

    NARCIS (Netherlands)

    Ketner-Oostra, R.; Sparrius, L.B.; Sýkora, K.V.; Fanta, J.; Siepel, H.

    2010-01-01

    The pioneer vegetation of inland dunes is known for its lichen diversity. The development of lichen-rich vegetation may take several decades after the first pioneer stage with Corynephorus canescens and Polytrichum piliferum. The neophytic moss Campylopus introflexus and atmospheric nitrogen

  11. PREPARATION OF NOVOLACS USING PHENOLIC RICH ...

    African Journals Online (AJOL)

    Preferred Customer

    ABSTRACT. The possibility of using phenolic rich components (water insoluble fraction) from biomass pyrolysis oil as partial substitute of phenol in synthesis of high-ortho phenolic novolac under the catalyst of. HCl/Zn(AC)2 has been proved using differential scanning calorimetry (DSC) and Fourier transformed infrared.

  12. Why are Rich Countries more Politically Cohesive?

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Olsson, Ola

    We document empirically that rich countries are more politically cohesive than poorer countries. In order to explain this regularity, we provide a model where political cohesion is linked to the emergence of a fully  functioning market economy. Without market exchange, the welfare of inherently...

  13. Platelet-rich plasma in clinical practice

    African Journals Online (AJOL)

    their replacement.2 Platelet-rich plasma (PRP) is cell-free plasma with a concentrated level of .... relates to osteoarthritis of the knee. The data suggest ... Proliferation and chemotaxis of fibroblasts. Mitognenesis of mesenchymal stem cells and endothelial cells. Synthesis of extracellular matrix and hyaluronan production.

  14. Leukocyte activation by triglyceride-rich lipoproteins

    NARCIS (Netherlands)

    A. Alipour (Arash); A.J.H.H.M. van Oostrom; A. Izraeljan (Alisa); C. Verseyden; J.M. Collins (Jennifer); K.N. Frayn (Keith); T.W.M. Plokker (Thijs); J.W.F. Elte (Jan Willem); M. Castro Cabezas (Manuel)

    2008-01-01

    textabstractOBJECTIVE - Postprandial lipemia has been linked to atherosclerosis and inflammation. Because leukocyte activation is obligatory for atherogenesis, leukocyte activation by triglyceride-rich lipoproteins (TRLs) was investigated. METHODS AND RESULTS - The expression of CD11b and CD66b

  15. A Rich Metadata Filesystem for Scientific Data

    Science.gov (United States)

    Bui, Hoang

    2012-01-01

    As scientific research becomes more data intensive, there is an increasing need for scalable, reliable, and high performance storage systems. Such data repositories must provide both data archival services and rich metadata, and cleanly integrate with large scale computing resources. ROARS is a hybrid approach to distributed storage that provides…

  16. Leveraging data rich environments using marketing analytics

    NARCIS (Netherlands)

    Holtrop, Niels

    2017-01-01

    With the onset of what is popularly known as “big data”, increased attention is being paid to creating value from these data rich environments. Within the field of marketing, the analysis of customer and market data supported by models is known as marketing analytics. The goal of these analyses is

  17. The Use of Platelet-Rich Plasma for Storage of Surplus Harvested Skin Grafts.

    Science.gov (United States)

    Keskin, Ilknur; Ayturk, Nilufer; Sutcu, Mustafa; Keskin, Mustafa; Mudok, Tangul

    2017-02-01

    There is a need for improved methods and storage media to sustain the tissue viability of autologous skin grafts. To compare histological changes in human skin grafts stored in platelet-rich plasma (PRP) with those of grafts stored in saline. Eight circular, 3-mm full-thickness skin graft samples were harvested from the abdominal skin of each of 5 patients scheduled to undergo an abdominoplasty procedure. Four of these graft samples were stored in saline, and the other 4 were stored in saline mixed with PRP prepared from the patient's own venous blood. Histological assessment of the microscopic appearance of the samples was performed on days 5, 8, 11, and 14. The integrity of the epidermal-dermal junction, number of keratinocytes with perinuclear halos, collagen organization, and number of fibroblasts per field were assessed. The cellular apoptosis rate was also measured on these same days. On day 5, significant differences were observed microscopically between the PRP- and saline-stored grafts (P nuclear swelling with pleomorphism, as well as early nuclear halo formation. The cell viability rate of the PRP group was significantly higher than that of the saline-stored group on day 8 (P < .05). Platelet-rich plasma and its inherent growth factors supported longer graft survival; however, its effect lasted only until day 8. Platelet-rich plasma may be beneficial if grafts need to be stored for delayed application(s).

  18. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... may be placed into the bladder, which may cause temporary discomfort. It is important that your child ... images are being recorded. Though nuclear imaging itself causes no pain, children may experience some discomfort from ...

  19. Nuclear Fuel Reprocessing

    Energy Technology Data Exchange (ETDEWEB)

    Michael F. Simpson; Jack D. Law

    2010-02-01

    This is an a submission for the Encyclopedia of Sustainable Technology on the subject of Reprocessing Spent Nuclear Fuel. No formal abstract was required for the article. The full article will be attached.

  20. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... as well as a patient’s immediate response to therapeutic interventions. Children's (pediatric) nuclear medicine refers to imaging ... top of page Additional Information and Resources The Alliance for Radiation Safety in Pediatric Imaging's "Image Gently" ...

  1. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... variety of diseases, including many types of cancers, heart disease, gastrointestinal, endocrine, neurological disorders and other abnormalities ... and bladder. bones. liver and gallbladder. gastrointestinal tract. heart. lungs. brain. thyroid. Nuclear medicine scans are typically ...

  2. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... can be superimposed with computed tomography (CT) or magnetic resonance imaging (MRI) to produce special views, a ... In contrast, nuclear medicine procedures use a radioactive material, called a radiopharmaceutical or radiotracer, which is injected ...

  3. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... and still during imaging. Comfort items such as pacifiers, blankets and books are also very helpful. Often, ... illnesses or other medical conditions. Depending on the type of nuclear scan being performed, you will receive ...

  4. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... leaving the nuclear medicine facility. Through the natural process of radioactive decay, the small amount of radiotracer ... possible charges you will incur. Web page review process: This Web page is reviewed regularly by a ...

  5. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... stool. Your child should also drink plenty of water to help flush the radioactive material from his ... substantially shorten the procedure time. The resolution of structures of the body with nuclear medicine may not ...

  6. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... molecular information. In many centers, nuclear medicine images can be superimposed with computed tomography (CT) or magnetic ... small hand-held device resembling a microphone that can detect and measure the amount of the radiotracer ...

  7. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... including many types of cancers, heart disease, gastrointestinal, endocrine, neurological disorders and other abnormalities within the body. ... Physicians use nuclear medicine imaging to evaluate organ systems, including the: kidneys and bladder. bones. liver and ...

  8. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... endocrine, neurological disorders and other abnormalities within the body. Because nuclear medicine procedures are able to pinpoint molecular activity within the body, they offer the potential to identify disease in ...

  9. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... as well as a patient’s immediate response to therapeutic interventions. Children's (pediatric) nuclear medicine refers to imaging ... be needed for the duration of the exam. Oral: for some exams, the radiotracer is taken by ...

  10. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... used. Most nuclear medicine exams will involve an injection in a vein in your child’s arm or ... are noninvasive and, with the exception of intravenous injections, are usually painless medical tests that help physicians ...

  11. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... nuclear medicine imaging uses small amounts of radioactive materials called radiotracers, a special camera and a computer ... medical imaging that uses small amounts of radioactive material to diagnose and determine the severity of or ...

  12. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... differently than when breathing room air or holding his or her breath. With some exams, a catheter ... physician tells you otherwise, your child may resume his/her normal activities after the nuclear medicine scan. ...

  13. International Nuclear Security

    Energy Technology Data Exchange (ETDEWEB)

    Doyle, James E. [Los Alamos National Laboratory

    2012-08-14

    This presentation discusses: (1) Definitions of international nuclear security; (2) What degree of security do we have now; (3) Limitations of a nuclear security strategy focused on national lock-downs of fissile materials and weapons; (4) What do current trends say about the future; and (5) How can nuclear security be strengthened? Nuclear security can be strengthened by: (1) More accurate baseline inventories; (2) Better physical protection, control and accounting; (3) Effective personnel reliability programs; (4) Minimize weapons-usable materials and consolidate to fewer locations; (5) Consider local threat environment when siting facilities; (6) Implement pledges made in the NSS process; and (7) More robust interdiction, emergency response and special operations capabilities. International cooperation is desirable, but not always possible.

  14. Recapitalizing Nuclear Weapons

    National Research Council Canada - National Science Library

    Vaughan, Edgar M

    2007-01-01

    The US nuclear weapons stockpile is aging and undergoing an extensive and expensive life-extension program to ensure the continuing safety, security, and reliability of the legacy weapons well into the future...

  15. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... the procedure? How does the nuclear medicine procedure work? What does the equipment look like? How is the procedure performed? What will my child experience during and after the procedure? How should ...

  16. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... bladder. bones. liver and gallbladder. gastrointestinal tract. heart. lungs. brain. thyroid. Nuclear medicine scans are typically used ... gas via a mask, such as with a lung scan. Bladder: some exams require a catheter to ...

  17. Nuclear Waste and Ethics

    Energy Technology Data Exchange (ETDEWEB)

    Damveld, Herman [Groningen (Netherlands)

    2003-10-01

    In the past years in almost all conferences on storage of nuclear waste, ethics has been considered as an important theme. But what is ethics? We will first give a sketch of this branch of philosophy. We will then give a short explanation of the three principal ethical theories. In the discussion about storage of nuclear waste, the ethical theory of utilitarianism is often implicitly invoked. In this system future generations weigh less heavily than the present generation, so that people of the future are not considered as much as those now living. We reject this form of reasoning. The discussion about nuclear waste is also sometimes pursued from ethical points of departure such as equality and justice. But many loose ends remain in these arguments, which gives rise to the question of whether the production and storage of nuclear waste is responsible.

  18. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... Because the doses of radiotracer administered are small, diagnostic nuclear medicine procedures result in low radiation exposure, acceptable for diagnostic exams. Thus, the radiation risk is very low ...

  19. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... are some common uses of the procedure? Children's (pediatric) nuclear medicine imaging is performed to help diagnose childhood disorders that are congenital (present at birth) or that develop during childhood. ...

  20. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... or treat a variety of diseases, including many types of cancers, heart disease, gastrointestinal, endocrine, neurological disorders and other abnormalities within the body. Because nuclear medicine procedures are ...

  1. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... kidneys and bladder. bones. liver and gallbladder. gastrointestinal tract. heart. lungs. brain. thyroid. Nuclear medicine scans are typically used to help diagnose and evaluate: urinary blockage in the kidney. backflow of urine from ...

  2. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... of page How does the nuclear medicine procedure work? With ordinary x-ray examinations, an image is ... The exception to this is if the child’s mother is pregnant. When the examination is completed, your ...

  3. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... the radiotracer will be inhaled as a gas via a mask, such as with a lung scan. ... being recorded. Though nuclear imaging itself causes no pain, children may experience some discomfort from having to ...

  4. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... the procedure? Except for intravenous injections, most nuclear medicine procedures are painless and are rarely associated with significant discomfort or side effects. If the radiotracer is given intravenously, your child ...

  5. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... medications and allergies. Depending on the type of exam, your doctor will instruct you on what your ... sedation is to be used. Most nuclear medicine exams will involve an injection in a vein in ...

  6. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... a special camera or imaging device that produces pictures and provides molecular information. In many centers, nuclear ... and with the help of a computer, create pictures offering details on both the structure and function ...

  7. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... or that develop during childhood. Physicians use nuclear medicine imaging to evaluate organ systems, including the: kidneys and bladder. bones. liver and gallbladder. gastrointestinal tract. heart. lungs. brain. thyroid. ...

  8. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... in its earliest stages as well as a patient’s immediate response to therapeutic interventions. Children's (pediatric) nuclear medicine refers to imaging examinations done in ...

  9. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... done in babies, young children and teenagers. Nuclear medicine imaging procedures are noninvasive and, with the exception of intravenous injections, are usually painless medical tests that help physicians diagnose and evaluate medical conditions. ...

  10. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... are rarely associated with significant discomfort or side effects. If the radiotracer is given intravenously, your child ... diagnostic nuclear medicine procedures result in low radiation exposure, acceptable for diagnostic exams. Thus, the radiation risk ...

  11. Nuclear material operations manual

    Energy Technology Data Exchange (ETDEWEB)

    Tyler, R.P.

    1981-02-01

    This manual provides a concise and comprehensive documentation of the operating procedures currently practiced at Sandia National Laboratories with regard to the management, control, and accountability of nuclear materials. The manual is divided into chapters which are devoted to the separate functions performed in nuclear material operations-management, control, accountability, and safeguards, and the final two chapters comprise a document which is also issued separately to provide a summary of the information and operating procedures relevant to custodians and users of radioactive and nuclear materials. The manual also contains samples of the forms utilized in carrying out nuclear material activities. To enhance the clarity of presentation, operating procedures are presented in the form of playscripts in which the responsible organizations and necessary actions are clearly delineated in a chronological fashion from the initiation of a transaction to its completion.

  12. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... stool. Your child should also drink plenty of water to help flush the radioactive material from his ... radiation risk is very low compared with the potential benefits. Nuclear medicine diagnostic procedures have been used ...

  13. Living with nuclear weapons

    Energy Technology Data Exchange (ETDEWEB)

    Carnesale, A.; Doty, P.; Hoffmann, S.; Huntington, S.P.; Nye, J.S. Jr.; Sagan, S.D.

    1983-01-01

    At Harvard President Derek Bok's request, six Harvard professors explain nuclear arms issues to help citizens understand all sides of the national security debates. The goal is to encourage public participation in policy formulation. The book emphasizes that escapism will not improve security; that idealistic plans to eliminate nuclear weapons are a form of escapism. Learning to live with nuclear weapons, they suggest, requires an understanding of the current nuclear predicament and the implications of alternative weapons and policy choices. After reviewing these matters, they emphasize that informed persons will continue to disagree, but that knowledge will improve understanding and appreciation of their differences and improve the quality of policy debates. 54 references, 5 figures, 2 tables. (DCK)

  14. Desalting and Nuclear Energy

    Science.gov (United States)

    Burwell, Calvin C.

    1971-01-01

    Future use of nuclear energy to produce electricity and desalted water is outlined. Possible desalting processes are analyzed to show economic feasibility and the place in planning in world's economic growth. (DS)

  15. Nuclear Test Limitations Issues

    National Research Council Canada - National Science Library

    Mahoney, Rob

    2000-01-01

    .... It also summarizes public views concerning test limitations and the nuclear stockpile. The second portion of the paper appraises issues that developed during consideration of the CTBT that involve 1...

  16. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... top of page What are the benefits vs. risks? Benefits The information provided by nuclear medicine examinations ... diagnosis or to determine appropriate treatment, if any. Risks Because the doses of radiotracer administered are small, ...

  17. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... of page How does the nuclear medicine procedure work? With ordinary x-ray examinations, an image is ... such low-dose exposure. For more information about safety in pediatric radiology procedures, visit the Image Gently ...

  18. Modeling nuclear explosion

    Science.gov (United States)

    Redd, Jeremy; Panin, Alexander

    2012-10-01

    As a result of the Nuclear Test Ban Treaty, no nuclear explosion tests have been performed by the US since 1992. This appreciably limits valuable experimental data needed for improvement of existing weapons and development of new ones, as well as for use of nuclear devices in non-military applications (such as making underground oil reservoirs or compressed air energy storages). This in turn increases the value of numerical modeling of nuclear explosions and of their effects on the environment. We develop numerical codes simulating fission chain reactions in a supercritical U and Pu core and the dynamics of the subsequent expansion of generated hot plasma in order to better understand the impact of such explosions on their surroundings. The results of our simulations (of both above ground and underground explosions) of various energy yields are presented.

  19. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... determine appropriate treatment, if any. Risks Because the doses of radiotracer administered are small, diagnostic nuclear medicine procedures result in low radiation exposure, acceptable for diagnostic exams. Thus, the radiation ...

  20. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... used in children with cancer, epilepsy and back pain. top of page What does the equipment look ... being recorded. Though nuclear imaging itself causes no pain, children may experience some discomfort from having to ...

  1. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... computer, create pictures offering details on both the structure and function of organs and tissues in your ... substantially shorten the procedure time. The resolution of structures of the body with nuclear medicine may not ...

  2. Low temperature nuclear heat

    Energy Technology Data Exchange (ETDEWEB)

    Kotakorpi, J.; Tarjanne, R. (comps.)

    1977-08-01

    The meeting was concerned with the use of low grade nuclear heat for district heating, desalination, process heat, and agriculture and aquaculture. The sessions covered applications and demand, heat sources, and economics.

  3. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... organs and tissues in your body. Hybrid imaging techniques (PET/CT, SPECT/CT and PET/MR) are ... equipment look like? The special camera and imaging techniques used in nuclear medicine include the gamma camera ...

  4. The Nuclear Strategy Tripod

    DEFF Research Database (Denmark)

    Nellemann, Camilla

    In March 2011, the global nuclear industry was struck by the Fukushima accident which immediately and greatly affected the global business environment for nuclear power. I analyze how the industry-leader Toshiba adapted to the changing circumstances from the perspectives of the strategy tripod...... is that the company maintains its strategy for nuclear power because the management perceives the negative consequences of 3/11 as manageable........ However, I amend the tripod-framework by defining operationalizable variables based on my literature review of nuclear research to be able to apply it in my study. At the industry level, I identify coopetitive behavior as the most important variable, while the critical resources and capabilities...

  5. 2011 Japanese Nuclear Incident

    Science.gov (United States)

    EPA’s RadNet system monitored the environmental radiation levels in the United States and parts of the Pacific following the Japanese Nuclear Incident. Learn about EPA’s response and view historical laboratory data and news releases.

  6. Nuclear data interface retrospective

    Energy Technology Data Exchange (ETDEWEB)

    Gray, Mark G [Los Alamos National Laboratory

    2008-01-01

    The Nuclear Data Interface (NDI) code library and data formats are the standards for multigroup nuclear data at Los Alamos National Laboratory. NDI's analysis, design, implementation, testing, integration, and maintenance required a ten person-year and ongoing effort by the Nuclear Data Team. Their efforts provide a unique, contemporary experience in producing a standard component library. In reflection upon that experience at NDI's decennial, we have identified several factors critical to NDI's success: it addressed real problems with appropriate simplicity, it fully supported all users, it added extra value through the code to the raw nuclear data, and its team went the distance from analysis through maintenance. In this report we review these critical success factors and discuss their implications for future standardization projects.

  7. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... when breathing room air or holding his or her breath. With some exams, a catheter may be ... tells you otherwise, your child may resume his/her normal activities after the nuclear medicine scan. If ...

  8. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... of the thyroid gland. top of page How does the nuclear medicine procedure work? With ordinary x- ... epilepsy and back pain. top of page What does the equipment look like? The special camera and ...

  9. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... the procedure. top of page Who interprets the results and how do we get them? A radiologist ... radiotracer administered are small, diagnostic nuclear medicine procedures result in low radiation exposure, acceptable for diagnostic exams. ...

  10. Western Nuclear Science Alliance

    Energy Technology Data Exchange (ETDEWEB)

    Steve Reese; George Miller; Stephen Frantz; Denis Beller; Denis Beller; Ed Morse; Melinda Krahenbuhl; Bob Flocchini; Jim Elliston

    2010-12-07

    The primary objective of the INIE program is to strengthen nuclear science and engineering programs at the member institutions and to address the long term goal of the University Reactor Infrastructure and Education Assistance Program.

  11. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... earliest stages as well as a patient’s immediate response to therapeutic interventions. Children's (pediatric) nuclear medicine refers ... Contact Us | FAQ | Privacy | Terms of Use | Links | Site Map Copyright © 2018 Radiological Society of North America, ...

  12. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... information you were looking for? Yes No Please type your comment or suggestion into the following text box: Comment: ... Images related to Children's (Pediatric) Nuclear Medicine Videos ...

  13. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... is performed to help diagnose childhood disorders that are congenital (present at birth) or that develop during childhood. Physicians use nuclear medicine imaging to evaluate organ systems, including the: kidneys and bladder. bones. liver and ...

  14. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... radiation exposure, acceptable for diagnostic exams. Thus, the radiation risk is very low compared with the potential benefits. Nuclear medicine diagnostic procedures have been used for more than ...

  15. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... of page How does the nuclear medicine procedure work? With ordinary x-ray examinations, an image is ... your child or the camera will stay in one position and your child will be asked to ...

  16. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... body. jaundice in newborns and older children. epilepsy . location, anatomy and function of the thyroid gland. top ... to be followed after leaving the nuclear medicine facility. Through the natural process of radioactive decay, the ...

  17. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... both imaging exams at the same time. An emerging imaging technology, but not readily available at this ... top of page What are the benefits vs. risks? Benefits The information provided by nuclear medicine examinations ...

  18. Nuclear Mechanics in Disease

    Science.gov (United States)

    Zwerger, Monika; Ho, Chin Yee; Lammerding, Jan

    2015-01-01

    Over the past two decades, the biomechanical properties of cells have emerged as key players in a broad range of cellular functions, including migration, proliferation, and differentiation. Although much of the attention has focused on the cytoskeletal networks and the cell’s microenvironment, relatively little is known about the contribution of the cell nucleus. Here, we present an overview of the structural elements that determine the physical properties of the nucleus and discuss how changes in the expression of nuclear components or mutations in nuclear proteins can affect not only nuclear mechanics but also modulate cytoskeletal organization and diverse cellular functions. These findings illustrate that the nucleus is tightly integrated into the surrounding cellular structure. Consequently, changes in nuclear structure and composition are highly relevant to normal development and physiology and can contribute to many human diseases, such as muscular dystrophy, dilated cardiomyopathy, (premature) aging, and cancer. PMID:21756143

  19. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... small amount of energy in the form of gamma rays. Special cameras detect this energy, and with ... imaging techniques used in nuclear medicine include the gamma camera and single-photon emission-computed tomography (SPECT). ...

  20. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... until the nuclear physician checks the images in case additional images are needed. top of page What ... will lose its radioactivity over time. In many cases, the radioactivity will dissipate over the first 24 ...

  1. Evolution of nuclear spectroscopy at Saha Institute of Nuclear Physics

    Indian Academy of Sciences (India)

    physics pp. 5–9. Evolution of nuclear spectroscopy at Saha Institute of Nuclear Physics. P MUKHERJEE. Formerly of Saha Institute of Nuclear Physics, Kolkata 700 064, India. Present Address: 85 Block A, Bangur Avenue, Kolkata 700 055, India. Abstract. Experimental studies of nuclear excitations have been an important ...

  2. Restructuring nuclear regulations.

    OpenAIRE

    Mossman, Kenneth L

    2003-01-01

    Nuclear regulations are a subset of social regulations (laws to control activities that may negatively impact the environment, health, and safety) that concern control of ionizing radiation from radiation-producing equipment and from radioactive materials. The impressive safety record among nuclear technologies is due, in no small part, to the work of radiation safety professionals and to a protection system that has kept pace with the rapid technologic advancements in electric power generati...

  3. Nuclear Plant Inspection

    Science.gov (United States)

    1983-01-01

    Engineers from the Power Authority of the State of New York use a Crack Growth Analysis Program supplied by COSMIC (Computer Software Management and Information Center) in one stage of nuclear plant inspection. Welds of the nuclear steam supply system are checked for cracks; radiographs, dye penetration and visual inspections are performed to locate cracks in the metal structure and welds. The software package includes three separate crack growth analysis models and enables necessary repairs to be planned before serious problems develop.

  4. JPRS Report, Nuclear Developments

    Science.gov (United States)

    1991-04-23

    version of anti-aircraft, shoulder -fired apparent reason being her full readiness in nuclear and missile system to be known with Pakistani designation of...its being a shoulder -fired capability like the Stinger, a credible "nuclear deterrent" to avoid the dangers of Sam-7 and RBS-20". war permanently in the...balance. A readaptation launched group of European NATO nations and made it clear that with much fanfare last year with the publication of a Europe

  5. Pakistans Nuclear Weapons

    Science.gov (United States)

    2016-02-12

    intensity conflict or proxy war in Kashmir , while effectively deterring India at the strategic level. 96 In any case, Pakistani statements suggest that the ...Furthermore, continued Indian and Pakistani nuclear weapons development could jeopardize strategic stability between the two countries. For a...context where these broader tensions and conflicts are present. 1 Pakistani efforts to improve the security of its nuclear weapons have been ongoing

  6. Superpower nuclear minimalism

    Energy Technology Data Exchange (ETDEWEB)

    Graben, E.K.

    1992-01-01

    During the Cold War, the United States and the Soviet Union competed in building weapons -- now it seems like America and Russia are competing to get rid of them the fastest. The lengthy process of formal arms control has been replaced by exchanges of unilateral force reductions and proposals for reciprocal reductions not necessarily codified by treaty. Should superpower nuclear strategies change along with force postures President Bush has yet to make a formal pronouncement on post-Cold War American nuclear strategy, and it is uncertain if the Soviet/Russian doctrine of reasonable sufficiency formulated in the Gorbachev era actually heralds a change in strategy. Some of the provisions in the most recent round of unilateral proposals put forth by Presidents Bush and Yeltsin in January 1992 are compatible with a change in strategy. Whether such a change has actually occurred remains to be seen. With the end of the Cold War and the breakup of the Soviet Union, the strategic environment has fundamentally changed, so it would seem logical to reexamine strategy as well. There are two main schools of nuclear strategic thought: a maximalist school, mutual assured destruction (MAD) which emphasizes counterforce superiority and nuclear war- fighting capability, and a MAD-plus school, which emphasizes survivability of an assured destruction capability along with the ability to deliver small, limited nuclear attacks in the event that conflict occurs. The MAD-plus strategy is based on an attempt to conventionalize nuclear weapons which is unrealistic.

  7. Plant nuclear photorelocation movement.

    Science.gov (United States)

    Higa, Takeshi; Suetsugu, Noriyuki; Wada, Masamitsu

    2014-06-01

    Organelle movement and positioning are essential for proper cellular function. A nucleus moves dynamically during cell division and differentiation and in response to environmental changes in animal, fungal, and plant cells. Nuclear movement is well-studied and the mechanisms have been mostly elucidated in animal and fungal cells, but not in plant cells. In prothallial cells of the fern Adiantum capillus-veneris and leaf cells of the flowering plant Arabidopsis thaliana, light induces nuclear movement and nuclei change their position according to wavelength, intensity, and direction of light. This nuclear photorelocation movement shows some common features with the photorelocation movement of chloroplasts, which is one of the best-characterized plant organelle movements. This review summarizes nuclear movement and positioning in plant cells, especially plant-specific nuclear photorelocation movement and discusses the relationship between nuclear photorelocation movement and chloroplast photorelocation movement. © The Author 2013. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  8. Nuclear Energy's Renaissance

    Science.gov (United States)

    Kadak, Andrew C.

    2006-10-01

    Nuclear energy is about to enter its renaissance. After almost 30 years of new plant construction dormancy, utilities are seriously preparing for ordering new plants in the next two years. This resurgence in interest is based on improved plant performance, new Nuclear Regulatory Commission licensing processes, significant incentives introduced by Congress in the Energy Policy Act of 2005 to encourage new orders, and new technologies that are competitive, simpler to operate and safer. These new evolutionary light water reactors will pave the way to more advanced high temperature gas reactors such as the pebble bed or prismatic reactors that will provide improved efficiency and safety leading to more process heat applications in oil extraction or hydrogen production. The Next Generation Nuclear Plant (NGNP) also authorized by the Energy Policy act will provide the fundamental technical basis for the future of these technologies. Progress continues on the Yucca Mountain nuclear waste disposal site enabling this expansion. When coupled with the long term strategy of waste minimization through reprocessing and actinide destruction as proposed in the Global Nuclear Energy Partnership, the future of nuclear energy as part of this nation's energy mix appears to be assured.

  9. SURFACE SYMMETRY ENERGY OF NUCLEAR ENERGY DENSITY FUNCTIONALS

    Energy Technology Data Exchange (ETDEWEB)

    Nikolov, N; Schunck, N; Nazarewicz, W; Bender, M; Pei, J

    2010-12-20

    We study the bulk deformation properties of the Skyrme nuclear energy density functionals. Following simple arguments based on the leptodermous expansion and liquid drop model, we apply the nuclear density functional theory to assess the role of the surface symmetry energy in nuclei. To this end, we validate the commonly used functional parametrizations against the data on excitation energies of superdeformed band-heads in Hg and Pb isotopes, and fission isomers in actinide nuclei. After subtracting shell effects, the results of our self-consistent calculations are consistent with macroscopic arguments and indicate that experimental data on strongly deformed configurations in neutron-rich nuclei are essential for optimizing future nuclear energy density functionals. The resulting survey provides a useful benchmark for further theoretical improvements. Unlike in nuclei close to the stability valley, whose macroscopic deformability hangs on the balance of surface and Coulomb terms, the deformability of neutron-rich nuclei strongly depends on the surface-symmetry energy; hence, its proper determination is crucial for the stability of deformed phases of the neutron-rich matter and description of fission rates for r-process nucleosynthesis.

  10. Sulphate in Liquid Nuclear Waste: from Production to Containment

    Energy Technology Data Exchange (ETDEWEB)

    Lenoir, M.; Grandjean, A.; Ledieu, A.; Dussossoy, J.L.; Cau Dit Coumes, C.; Barre, Y.; Tronche, E. [CEA Marcoule, DEN/DTCD/SECM/LDMC, Batiment 208 BP17171, Bagnols sur Ceze, 30207 (France)

    2009-06-15

    Nuclear industry produces a wide range of low and intermediate level liquid radioactive wastes which can include different radionuclides such as {sup 90}Sr. In La Hague reprocessing plant and in the nuclear research centers of CEA (Commissariat a l'Energie Atomique), the coprecipitation of strontium with barium sulphate is the technique used to treat selectively these contaminated streams with the best efficiency. After the decontamination process, low and intermediate level activity wastes incorporating significant quantities of sulphate are obtained. The challenge is to find a matrix easy to form and with a good chemical durability which is able to confine this kind of nuclear waste. The current process used to contain sulphate-rich nuclear wastes is bituminization. However, in order to improve properties of containment matrices and simplify the process, CEA has chosen to supervise researches on other materials such as cements or glasses. Indeed, cements are widely used for the immobilization of a variety of wastes (low and intermediate level wastes) and they may be an alternative matrix to bitumen. Even if Portland cement, which is extensively used in the nuclear industry, presents some disadvantages for the containment of sulphate-rich nuclear wastes (risk of swelling and cracking due to delayed ettringite formation), other cement systems, such as calcium sulfo-aluminate binders, may be valuable candidates. Another matrix to confine sulphate-rich waste could be the glass. One of the advantages of this material is that it could also immobilize sulphate containing high level nuclear waste which is present in some countries. This waste comes from the use of ferrous sulfamate as a reducing agent for the conversion of Pu{sup 4+} to Pu{sup 3+} in the partitioning stage of the actinides during reprocessing. Sulphate solubility in borosilicate glasses has already been studied in CEA at laboratory and pilot scales. At a pilot scale, low level liquid waste has been

  11. Calcium-aluminum-rich inclusions with fractionation and unknown nuclear effects (FUN CAIs)

    DEFF Research Database (Denmark)

    Krot, Alexander N.; Nagashima, Kazuhide; Wasserburg, Gerald J.

    2014-01-01

    and gas-melt oxygen-isotope exchange in a 16O-poor gaseous reservoir that resulted in crystallization of 16O-depleted fassaite, melilite and plagioclase. The final oxygen isotopic compositions of melilite and plagioclase in the CV FUN CAIs may have been established on the CV parent asteroid as a result...

  12. Micro-IL and micro-PIXE studies of rich diamond meteorites at Legnaro nuclear microprobe

    Energy Technology Data Exchange (ETDEWEB)

    Lo Giudice, A. E-mail: logiudice@ph.unito.it; Pratesi, G.; Olivero, P.; Paolini, C.; Vittone, E.; Manfredotti, C.; Sammiceli, F.; Rigato, V

    2003-09-01

    A combination of micro-ionoluminescence (micro-IL) and micro-PIXE was used to characterize diamond grains inside a type of meteorites known as ureilites. Ureilites are a group of achondrites unique in containing relatively large amounts of carbon occurring as diamond, graphite or lonsdaleite. A shock origin for ureilitic diamonds has been widely accepted though an exact knowledge of the conditions during high-pressure graphite conversion is not yet achieved. Micro-IL is a very powerful technique for material investigation and particularly for diamond analysis. Using this technique we were able to identify the occurrence of the diamond phase inside carbon meteoritic inclusions and to perform micro-PIXE analysis on single diamond grains. In fact, IL in low nitrogen content diamonds is dominated by A-band emission (centered at about 2.9 eV) and so, considering only IL monochromatic map at such a spectral band, it was possible to identify them. By making measurements directly on the meteorites, contamination during chemical extraction processes was avoided and it was possible to study not only the diamond phase, but also its distribution inside carbon inclusions.

  13. Nuclear magnetic resonance and sound velocity measurements of chalk saturated with magnesium rich brine

    DEFF Research Database (Denmark)

    Katika, Konstantina; Alam, Mohammad Monzurul; Fabricius, Ida Lykke

    2013-01-01

    composition. In this study we relate NMR data to changes in P-wave velocity and electrical resistivity. Core plugs from outcrop Stevns chalk, of 44% porosity, were divided into groups of three and saturated with deionized water, calcite equilibrated water, as well as sodium chloride and magnesium chloride...

  14. Identification and functional characterization of a novel bipartite nuclear localization sequence in ARID1A

    Energy Technology Data Exchange (ETDEWEB)

    Bateman, Nicholas W. [Women' s Health Integrated Research Center at Inova Health System, Gynecologic Cancer Center of Excellence, Annandale 22003, VA (United States); The John P. Murtha Cancer Center, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda 20889, MD (United States); Shoji, Yutaka [Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids 49503, MI (United States); Conrads, Kelly A.; Stroop, Kevin D. [Women' s Health Integrated Research Center at Inova Health System, Gynecologic Cancer Center of Excellence, Annandale 22003, VA (United States); Hamilton, Chad A. [Women' s Health Integrated Research Center at Inova Health System, Gynecologic Cancer Center of Excellence, Annandale 22003, VA (United States); The John P. Murtha Cancer Center, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda 20889, MD (United States); Gynecologic Oncology Service, Department of Obstetrics and Gynecology, Walter Reed National Military Medical Center, 8901 Wisconsin Ave, MD, Bethesda, 20889 (United States); Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda 20814, MD (United States); Darcy, Kathleen M. [Women' s Health Integrated Research Center at Inova Health System, Gynecologic Cancer Center of Excellence, Annandale 22003, VA (United States); The John P. Murtha Cancer Center, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda 20889, MD (United States); Maxwell, George L. [Department of Obstetrics and Gynecology, Inova Fairfax Hospital, Falls Church, VA 22042 (United States); Risinger, John I. [Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids 49503, MI (United States); and others

    2016-01-01

    AT-rich interactive domain-containing protein 1A (ARID1A) is a recently identified nuclear tumor suppressor frequently altered in solid tumor malignancies. We have identified a bipartite-like nuclear localization sequence (NLS) that contributes to nuclear import of ARID1A not previously described. We functionally confirm activity using GFP constructs fused with wild-type or mutant NLS sequences. We further show that cyto-nuclear localized, bipartite NLS mutant ARID1A exhibits greater stability than nuclear-localized, wild-type ARID1A. Identification of this undescribed functional NLS within ARID1A contributes vital insights to rationalize the impact of ARID1A missense mutations observed in patient tumors. - Highlights: • We have identified a bipartite nuclear localization sequence (NLS) in ARID1A. • Confirmation of the NLS was performed using GFP constructs. • NLS mutant ARID1A exhibits greater stability than wild-type ARID1A.

  15. Special AT-rich sequence binding protein 1 promotes tumor growth and metastasis of esophageal squamous cell carcinoma.

    Science.gov (United States)

    Ma, Jun; Wu, Kaiming; Zhao, Zhenxian; Miao, Rong; Xu, Zhe

    2017-03-01

    Esophageal squamous cell carcinoma is one of the most aggressive malignancies worldwide. Special AT-rich sequence binding protein 1 is a nuclear matrix attachment region binding protein which participates in higher order chromatin organization and tissue-specific gene expression. However, the role of special AT-rich sequence binding protein 1 in esophageal squamous cell carcinoma remains unknown. In this study, western blot and quantitative real-time polymerase chain reaction analysis were performed to identify differentially expressed special AT-rich sequence binding protein 1 in a series of esophageal squamous cell carcinoma tissue samples. The effects of special AT-rich sequence binding protein 1 silencing by two short-hairpin RNAs on cell proliferation, migration, and invasion were assessed by the CCK-8 assay and transwell assays in esophageal squamous cell carcinoma in vitro. Special AT-rich sequence binding protein 1 was significantly upregulated in esophageal squamous cell carcinoma tissue samples and cell lines. Silencing of special AT-rich sequence binding protein 1 inhibited the proliferation of KYSE450 and EC9706 cells which have a relatively high level of special AT-rich sequence binding protein 1, and the ability of migration and invasion of KYSE450 and EC9706 cells was distinctly suppressed. Special AT-rich sequence binding protein 1 could be a potential target for the treatment of esophageal squamous cell carcinoma and inhibition of special AT-rich sequence binding protein 1 may provide a new strategy for the prevention of esophageal squamous cell carcinoma invasion and metastasis.

  16. Delayed Particle Study of Neutron Rich Lithium Isotopes

    CERN Multimedia

    Marechal, F; Perrot, F

    2002-01-01

    We propose to make a systematic complete coincidence study of $\\beta$-delayed particles from the decay of neutron-rich lithium isotopes. The lithium isotopes with A=9,10,11 have proven to contain a vast information on nuclear structure and especially on the formation of halo nuclei. A mapping of the $\\beta$-strength at high energies in the daughter nucleus will make possible a detailed test of our understanding of their structure. An essential step is the comparison of $\\beta$-strength patterns in $^{11}$Li and the core nucleus $^{9}$Li, another is the full characterization of the break-up processes following the $\\beta$-decay. To enable such a measurement of the full decay process we will use a highly segmented detection system where energy and emission angles of both charged and neutral particles are detected in coincidence and with high efficiency and accuracy. We ask for a total of 30 shifts (21 shifts for $^{11}$Li, 9 shifts $^{9}$Li adding 5 shifts for setting up with stable beam) using a Ta-foil target...

  17. Transition probabilities in neutron-rich Se,8684

    Science.gov (United States)

    Litzinger, J.; Blazhev, A.; Dewald, A.; Didierjean, F.; Duchêne, G.; Fransen, C.; Lozeva, R.; Sieja, K.; Verney, D.; de Angelis, G.; Bazzacco, D.; Birkenbach, B.; Bottoni, S.; Bracco, A.; Braunroth, T.; Cederwall, B.; Corradi, L.; Crespi, F. C. L.; Désesquelles, P.; Eberth, J.; Ellinger, E.; Farnea, E.; Fioretto, E.; Gernhäuser, R.; Goasduff, A.; Görgen, A.; Gottardo, A.; Grebosz, J.; Hackstein, M.; Hess, H.; Ibrahim, F.; Jolie, J.; Jungclaus, A.; Kolos, K.; Korten, W.; Leoni, S.; Lunardi, S.; Maj, A.; Menegazzo, R.; Mengoni, D.; Michelagnoli, C.; Mijatovic, T.; Million, B.; Möller, O.; Modamio, V.; Montagnoli, G.; Montanari, D.; Morales, A. I.; Napoli, D. R.; Niikura, M.; Pollarolo, G.; Pullia, A.; Quintana, B.; Recchia, F.; Reiter, P.; Rosso, D.; Sahin, E.; Salsac, M. D.; Scarlassara, F.; Söderström, P.-A.; Stefanini, A. M.; Stezowski, O.; Szilner, S.; Theisen, Ch.; Valiente Dobón, J. J.; Vandone, V.; Vogt, A.

    2015-12-01

    Reduced quadrupole transition probabilities for low-lying transitions in neutron-rich Se,8684 are investigated with a recoil distance Doppler shift (RDDS) experiment. The experiment was performed at the Istituto Nazionale di Fisica Nucleare (INFN) Laboratori Nazionali di Legnaro using the Cologne Plunger device for the RDDS technique and the AGATA Demonstrator array for the γ -ray detection coupled to the PRISMA magnetic spectrometer for an event-by-event particle identification. In 86Se the level lifetime of the yrast 21+ state and an upper limit for the lifetime of the 41+ state are determined for the first time. The results of 86Se are in agreement with previously reported predictions of large-scale shell-model calculations using Ni78-I and Ni78-II effective interactions. In addition, intrinsic shape parameters of lowest yrast states in 86Se are calculated. In semimagic 84Se level lifetimes of the yrast 41+ and 61+ states are determined for the first time. Large-scale shell-model calculations using effective interactions Ni78-II, JUN45, jj4b, and jj4pna are performed. The calculations describe B (E 2 ;21+→01+) and B (E 2 ;61+→41+) fairly well and point out problems in reproducing the experimental B (E 2 ;41+→21+) .

  18. New routes for production of proton-rich Tc isotopes

    Science.gov (United States)

    Maiti, Moumita; Lahiri, Susanta

    2010-02-01

    Proton-rich Tc radionuclides have been identified as potential candidates for specific clinical and biological applications in the last decade. So far, these radionuclides have been produced either by proton-induced reaction on Mo targets or α-particle-induced reaction on Nb targets. This article lightens two heavy-ion-induced production routes of Tc93,94,95,96 radionuclides through Li7+natZr and Be9+natY reactions and provides important cross-sectional information in the projectile energy ranges 37-45 MeV and 30-48 MeV, respectively. Excitation functions of those reactions have been measured using the stacked-foil technique followed by the off-line γ-spectrometric studies. Measured cross-sectional data have been interpreted comparing theoretical predictions of the two nuclear reaction model codes PACE-II and ALICE91. Experimental cross sections agreed with the theory. Measured production cross sections of Tc94,95 have been compared with those produced from the α+93Nb reaction.

  19. Weighted species richness outperforms species richness as predictor of biotic resistance.

    Science.gov (United States)

    Henriksson, Anna; Yu, Jun; Wardle, David A; Trygg, Johan; Englund, Göran

    2016-01-01

    The species richness hypothesis, which predicts that species-rich communities should be better at resisting invasions than species-poor communities, has been empirically tested many times and is often poorly supported. In this study, we contrast the species richness hypothesis with four alternative hypotheses with the aim of finding better descriptors of invasion resistance. These alternative hypotheses state that resistance to invasions is determined by abiotic conditions, community saturation (i.e., the number of resident species relative to the maximum number of species that can be supported), presence/absence of key species, or weighted species richness. Weighted species richness is a weighted sum of the number of species, where each species' weight describes its contribution to resistance. We tested these hypotheses using data on the success of 571 introductions of four freshwater fish species into lakes throughout Sweden, i.e., Arctic char (Salvelinus alpinus), tench (Tinca tinca), zander (Sander lucioperca), and whitefish (Coregonus lavaretus). We found that weighted species richness best predicted invasion success. The weights describing the contribution of each resident species to community resistance varied considerably in both strength and sign. Positive resistance weights, which indicate that species repel invaders, were as common as negative resistance weights, which indicate facilitative interactions. This result can be contrasted with the implicit assumption of the original species richness hypothesis, that all resident species have negative effects on invader success. We argue that this assumption is unlikely to be true in natural communities, and thus that we expect that weighted species richness is a better predictor of invader success than the actual number of resident species.

  20. Revascularization of Immature Necrotic Teeth: Platelet rich Fibrin an Edge over Platelet rich Plasma

    OpenAIRE

    Neelam Mittal; Isha Narang

    2012-01-01

    Introduction: Revascularization is one such entity that has found its clinical application in the field of endodontics for the manage-ment of immature permanent necrotic teeth. The protocols for revascularization of such teeth focus especially on delivery of stem cells and scaffolds in a nonsurgical manner rather than concentrated growth micro molecules.The hypothesis: This article proposes the role of platelet concentrates such as platelet rich fibrin (PRF) and platelet rich plasma (PRP) in ...

  1. RICH upgrade: Current status and future perspectives

    CERN Document Server

    Pistone, A

    2016-01-01

    The LHCb experiment is dedicated to precision measurements of CP violation and rare decays of B hadrons at the Large Hadron Collider (LHC) at CERN (Geneva). The second long shutdown of the LHC is currently scheduled to begin in 2018. During this period the LHCb experiment with all its sub-detectors will be upgraded in order to run at an instantaneous luminosity of 2×10$^{33}$ cm$^{−2}$s$^{−1}$ and to read out data at a rate of 40MHz into a flexible software-based trigger. The Ring Imaging CHerenkov (RICH) system will require new photon detectors and modifications of the optics of the upstream detector. Tests of the prototype of the smallest constituent of the new RICH system have been performed during testbeam sessions at the Test Beam Facility SPS North Area (CERN) in Autumn 2014.

  2. Development of the RICH detectors in LHCb

    CERN Document Server

    Easo, S

    2003-01-01

    For particle identification, LHCb plans to use two RICH detectors, one covering the charged particle momentum range 1-65 GeV/c using aerogel and C//4F//1//0 radiators and the other covering up to 150 Ge V/c using CF//4 radiator. Hybrid photo diodes (HPD) with 80 mm photocathode diameter are being developed to detect the Cherenkov photons in the wavelength range 200-600 nm. The HPDs encapsulate silicon pixel anodes bump bonded to binary readout chips processed using 0.25 mum CMOS technology. Results obtained with prototype radiators and HPDs in test beams will be presented and the design and development of these RICH detectors will be reviewed.

  3. Die Usability von Rich Internet Applications

    Science.gov (United States)

    Linder, Jörg

    Interaktiven Services, die dem Themenkreis Web 2.0 zugeordnet werden, haftet unter anderem das Attribut an, besonders leicht bedienbar zu sein. Flickr, Youtube und Wikipedia gelten als Erfolgsprojekte dieser neuen Art von interaktiven Websites. Wodurch zeichnet sich nun eine Usability 2.0 (so es sie überhaupt geben sollte) aus? Was ist zu beachten, wenn so genannte Rich Internet Applications gestaltet werden?

  4. Nuclear Propulsion for Space (Rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Corliss, William R; Schwenk, Francis C

    1971-01-01

    The operation of nuclear rockets and a description of the development of nuclear rockets in the U.S. is given. Early developments and Project Rover, Project Pluto, and the NERVA (Nuclear Engine for Rocket Vehicle Application) Program are detailed. The Nuclear Rocket Development Station facilities in Nevada are described. The possibilities and advantages of using nuclear rockets for missions beginning from an earth orbit and moving outward toward higher earth orbits, the moon, and the planets are discussed.

  5. Let us learn nuclear power

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Wan Sang

    2006-08-15

    This book teach us nuclear power through nine chapters with recommendation and a prolog. The contents of this book are how did Formi become a scientist? what does atom look like? discover of neutron, what is an isotope?, power in the nuclear, various radiation, artificial nuclear transformation, nuclear fission and clinging atomic nucleus. It also has an appendix on SF story ; an atom bomb war. It explains basic nuclear physic in easy way with pictures.

  6. NUCLEAR CHEMISTRY ANNUAL REPORT 1970

    Energy Technology Data Exchange (ETDEWEB)

    Authors, Various

    1971-05-01

    Papers are presented for the following topics: (1) Nuclear Structure and Nuclear Properties - (a) Nuclear Spectroscopy and Radioactivity; (b) Nuclear Reactions and Scattering; (c) Nuclear Theory; and (d) Fission. (2) Chemical and Atomic Physics - (a) Atomic and Molecular Spectroscopy; and (b) Hyperfine Interactions. (3) Physical, Inorganic, and Analytical Chemistry - (a) X-Ray Crystallography; (b) Physical and Inorganic Chemistry; (c) Radiation Chemistry; and (d) Chemical Engineering. (4) Instrumentation and Systems Development.

  7. The COMPASS RICH-1 detector upgrade

    CERN Document Server

    Abbon, P; Angerer, H; Apollonio, M; Birsa, R; Bordalo, P; Bradamante, F; Bressan, A; Busso, L; Chiosso, M; Ciliberti, P; Colantoni, M L; Costa, S; Dalla Torre, S; Dafni, T; Delagnes, E; Deschamps, H; Díaz, V; Dibiase, N; Duic, V; Eyrich, W; Faso, D; Ferrero, A; Finger, M; Finger, M Jr; Fischer, H; Gerassimov, S; Giorgi, M; Gobbo, B; Hagemann, R; Von Harrach, D; Heinsius, F H; Joosten, R; Ketzer, B; Königsmann, K C; Kolosov, V N; Konorov, I; Kramer, Daniel; Kunne, F; Lehmann, A; Levorato, S; Maggiora, A; Magnon, A; Mann, A; Martin, A; Menon, G; Mutter, A; Nähle, O; Nerling, F; Neyret, D; Pagano, P; Panebianco, S; Panzieri, D; Paul, S; Pesaro, G; Polak, J; Rebourgeard, P; Robinet, F; Rocco, E; Schiavon, P; Schill, C; Schröder, W; Silva, L; Slunecka, M; Sozzi, F; Steiger, L; Sulc, M; Svec, M; Tessarotto, F; Teufel, A; Wollny, H

    2008-01-01

    The COMPASS experiment at CERN provides hadron identification in a wide momentum range employing a large size gaseous Ring Imaging CHerenkov detector (RICH). The presence of large uncorrelated background in the COMPASS environment was limiting the efficiency of COMPASS RICH-1 in the very forward regime. A major upgrade of RICH-1 required a new technique for Cherenkov photon detection at count rates of several 10$^{6}$/s per channel in the central detector part, and a read-out system allowing for trigger rates of up to 100 kHz. To cope with these requirements, the photon detectors of the central region have been replaced with a fast photon detection system described here, while, in the peripheral regions, the existing multi-wire proportional chambers with CsI photo-cathodes have been equipped with a new read-out system based on APV preamplifiers and flash ADC chips. The new system consists of multi-anode photomultiplier tubes (MAPMTs) coupled to individual fused silica lens telescopes, and fast read-out electr...

  8. Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Han; Sun, Yan Ping; Li, Yang [Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003 (China); Liu, Wen Wu [Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433 (China); Xiang, Hong Gang [Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003 (China); Fan, Lie Ying [Department of Clinical Laboratory, Shanghai East Hospital, Tong Ji University, Shanghai 200120 (China); Sun, Qiang [Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433 (China); Xu, Xin Yun [Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003 (China); Cai, Jian Mei [Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433 (China); Ruan, Can Ping; Su, Ning; Yan, Rong Lin [Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003 (China); Sun, Xue Jun, E-mail: sunxjk@hotmail.com [Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433 (China); Wang, Qiang, E-mail: wang2929@hotmail.com [Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003 (China)

    2010-03-05

    Molecular hydrogen, which reacts with the hydroxyl radical, has been considered as a novel antioxidant. Here, we evaluated the protective effects of hydrogen-rich saline on the L-arginine (L-Arg)-induced acute pancreatitis (AP). AP was induced in Sprague-Dawley rats by giving two intraperitoneal injections of L-Arg, each at concentrations of 250 mg/100 g body weight, with an interval of 1 h. Hydrogen-rich saline (>0.6 mM, 6 ml/kg) or saline (6 ml/kg) was administered, respectively, via tail vein 15 min after each L-Arg administration. Severity of AP was assessed by analysis of serum amylase activity, pancreatic water content and histology. Samples of pancreas were taken for measuring malondialdehyde and myeloperoxidase. Apoptosis in pancreatic acinar cell was determined with terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling technique (TUNEL). Expression of proliferating cell nuclear antigen (PCNA) and nuclear factor kappa B (NF-{kappa}B) were detected with immunohistochemistry. Hydrogen-rich saline treatment significantly attenuated the severity of L-Arg-induced AP by ameliorating the increased serum amylase activity, inhibiting neutrophil infiltration, lipid oxidation and pancreatic tissue edema. Moreover, hydrogen-rich saline treatment could promote acinar cell proliferation, inhibit apoptosis and NF-{kappa}B activation. These results indicate that hydrogen treatment has a protective effect against AP, and the effect is possibly due to its ability to inhibit oxidative stress, apoptosis, NF-{kappa}B activation and to promote acinar cell proliferation.

  9. Nuclear fundamentals remain

    Directory of Open Access Journals (Sweden)

    Stošić Zoran V.

    2012-01-01

    Full Text Available For Japan, the situation has become extremely difficult since counter-measures to deal with the nuclear accident had to be carried out along with dealing with the broader disaster caused by earthquake and the tsunami. In terms of damage, the Tohoku earthquake and the tsunami have caused the most fatalities and the largest economic loss ever from an earthquake and/or tsunami. The impact of this natural disaster is present not only in Japan but world-wide. The state of affairs in the global energy sector is affected by the consequences which may be lasting for decades. These effects are subject of this article dealing not with the nuclear accident at Fukushima Daiichi NPPs itself, but rather with the world-wide consequences and after effect on nuclear energy development. This includes: environmental damages, socio-economic effects, actions of safety authorities, extended protective measures against external events, the impact on global nuclear energy, triggered nuclear phase-outs and changes in new build plans as well as the sustainability of energy mix itself and an outlook.

  10. Nuclear multifragmentation: Basic concepts

    Indian Academy of Sciences (India)

    2014-05-02

    May 2, 2014 ... Application of the projectile fragmentation model for calculating average number of intermediate mass fragments and the average size of the largest cluster at different bound, differential charge distribution and cross-section of neutron-rich nuclei of different projectile fragmentation reactions at different ...

  11. History and Perspectives of Nuclear Medicine in Bangladesh

    Science.gov (United States)

    Hussain, Raihan

    2016-01-01

    Bangladesh is one of the smaller states in Asia. But it has a long and rich history of nuclear medicine for over sixty years. The progress in science and technology is always challenging in a developing country. In 1958, work for the first Nuclear Medicine facility was commenced in Dhaka in a tin-shed known as ‘Radioisotope Centre’ and was officially inaugurated in 1962. Since the late 50s of the last century nuclear medicine in Bangladesh has significantly progressed through the years in its course of development, but still the facilities are inadequate. At present there are 20 nuclear medicine establishments with 3 PET-CTs, 42 gamma camera/SPECTs with 95 physicians, 20 physicists, 10 radiochemists and 150 technologists. The Society of Nuclear Medicine, Bangladesh (SNMB) was formed in 1993 and publishing its official journal since 1997. Bangladesh also has close relationships with many international organizations like IAEA, ARCCNM, AOFNMB, ASNM, WFNMB and WARMTH. The history and the present scenario of the status of nuclear medicine in Bangladesh are being described here. PMID:27904875

  12. History and Perspectives of Nuclear Medicine in Bangladesh

    Directory of Open Access Journals (Sweden)

    Raihan Hussain

    2016-01-01

    Full Text Available Bangladesh is one of the smaller states in Asia. But it has a long and rich history of nuclear medicine for over sixty years. The progress in science and technology is always challenging in a developing country. In 1958, work for the first Nuclear Medicine facility was commenced in Dhaka in a tin-shed known as ‘Radioisotope Centre’ and was officially inaugurated in 1962. Since the late 50s of the last century nuclear medicine in Bangladesh has significantly progressed through the years in its course of development, but still the facilities are inadequate. At present there are 20 nuclear medicine establishments with 3 PET-CTs, 42 gamma camera/SPECTs with 95 physicians, 20 physicists, 10 radiochemists and 150 technologists. The Society of Nuclear Medicine, Bangladesh (SNMB was formed in 1993 and publishing its official journal since 1997. Bangladesh also has close relationships with many international organizations like IAEA, ARCCNM, AOFNMB, ASNM, WFNMB and WARMTH. The history and the present scenario of the status of nuclear medicine in Bangladesh are being described here.

  13. Model Action Plan for Nuclear Forensics and Nuclear Attribution

    Energy Technology Data Exchange (ETDEWEB)

    Dudder, G B; Niemeyer, S; Smith, D K; Kristo, M J

    2004-03-01

    Nuclear forensics and nuclear attribution have become increasingly important tools in the fight against illegal trafficking in nuclear and radiological materials. This technical report documents the field of nuclear forensics and nuclear attribution in a comprehensive manner, summarizing tools and procedures that have heretofore been described independently in the scientific literature. This report also provides national policy-makers, decision-makers, and technical managers with guidance for responding to incidents involving the interdiction of nuclear and radiological materials. However, due to the significant capital costs of the equipment and the specialized expertise of the personnel, work in the field of nuclear forensics has been restricted so far to a handful of national and international laboratories. In fact, there are a limited number of specialists who have experience working with interdicted nuclear materials and affiliated evidence. Most of the laboratories that have the requisite equipment, personnel, and experience to perform nuclear forensic analysis are participants in the Nuclear Smuggling International Technical Working Group or ITWG (see Section 1.8). Consequently, there is a need to disseminate information on an appropriate response to incidents of nuclear smuggling, including a comprehensive approach to gathering evidence that meets appropriate legal standards and to developing insights into the source and routes of nuclear and radiological contraband. Appendix A presents a ''Menu of Options'' for other Member States to request assistance from the ITWG Nuclear Forensics Laboratories (INFL) on nuclear forensic cases.

  14. Exotic octupole deformation in proton-rich Z=N nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Takami, Satoshi; Yabana, K. [Niigata Univ. (Japan); Matsuo, M.

    1998-03-01

    We study static non-axial octupole deformations in proton-rich Z=N nuclei, {sup 64}Ge, {sup 68}Se, {sup 72}Kr, {sup 76}Sr, {sup 80}Zr and {sup 84}Mo, by using the Skyrme Hartree-Fock plus BCS method with no restrictions on the nuclear shape. The calculation predicts that the oblate ground state in {sup 68}Se is extremely soft for the Y{sub 33} triangular deformation, and that in {sup 80}Zr the low-lying local minimum state coexisting with the prolate ground state has the Y{sub 32} tetrahedral deformation. (author)

  15. Optical polarization of neutron-rich sodium isotopes and $\\beta$-NMR measurements of quadrupole moments

    CERN Document Server

    Keim, M; Klein, A; Neugart, R; Neuroth, M; Wilbert, S; Lievens, P; Vermeeren, L

    1995-01-01

    The nuclear quadrupole moments of neutron-rich sodium isotopes are being investigated with the help of in-beam polarization by optical pumping in combination with $\\beta$-NMR techniques. First measurements have yielded the quadrupole splittings of NMR signals in the lattice of LiNbO$_{3}$ for the isotopes $^{26}$Na, $^{27}$Na and $^{28}$Na. Interaction constants and ratios of the electric quadrupole moments are derived. In view of future experiments, $\\beta$-decay asymmetries for the sequence of isotopes up to the $N$=20 neutron shell closure, $^{26-31}$Na, have been measured.

  16. Liquid-gas Coexistence Phase in Nuclear Matter

    Science.gov (United States)

    Salcedo, Alan; Lopez, Jorge; Terrazas, Sergio; Gaytan, Adrian

    2017-09-01

    Nuclear matter at low temperatures (T CMD). In this study, we present data obtained from CMD simulations and a method to determine a 3-dimensional phase diagram using these results, interpolation techniques, and Maxwell constructions. We performed more than 300 simulations of nuclear matter for settings of 2000 nucleons with isospin content X (Z/A) = 0.3, 0.35, 0.4, 0.45, 0.5 at temperatures of T = 1-5 MeV and T = 10-15 MeV, with densities between 0.02 fm-3 and 0.18 fm-3. Our results of pressure per nucleon for each system were stored and analyzed to construct a phase diagram. From this study, we aim to extract the boundaries and shape of the liquid-gas coexistence region for neutron-rich nuclear matter, thus determining its intrinsic physical conditions.

  17. Nuclear lattice simulations using symmetry-sign extrapolation

    Energy Technology Data Exchange (ETDEWEB)

    Laehde, Timo A.; Luu, Thomas [Forschungszentrum Juelich, Institute for Advanced Simulation, Institut fuer Kernphysik, and Juelich Center for Hadron Physics, Juelich (Germany); Lee, Dean [North Carolina State University, Department of Physics, Raleigh, NC (United States); Meissner, Ulf G. [Universitaet Bonn, Helmholtz-Institut fuer Strahlen- und Kernphysik and Bethe Center for Theoretical Physics, Bonn (Germany); Forschungszentrum Juelich, Institute for Advanced Simulation, Institut fuer Kernphysik, and Juelich Center for Hadron Physics, Juelich (Germany); Forschungszentrum Juelich, JARA - High Performance Computing, Juelich (Germany); Epelbaum, Evgeny; Krebs, Hermann [Ruhr-Universitaet Bochum, Institut fuer Theoretische Physik II, Bochum (Germany); Rupak, Gautam [Mississippi State University, Department of Physics and Astronomy, Mississippi State, MS (United States)

    2015-07-15

    Projection Monte Carlo calculations of lattice Chiral Effective Field Theory suffer from sign oscillations to a varying degree dependent on the number of protons and neutrons. Hence, such studies have hitherto been concentrated on nuclei with equal numbers of protons and neutrons, and especially on the alpha nuclei where the sign oscillations are smallest. Here, we introduce the ''symmetry-sign extrapolation'' method, which allows us to use the approximate Wigner SU(4) symmetry of the nuclear interaction to systematically extend the Projection Monte Carlo calculations to nuclear systems where the sign problem is severe. We benchmark this method by calculating the ground-state energies of the {sup 12}C, {sup 6}He and {sup 6}Be nuclei, and discuss its potential for studies of neutron-rich halo nuclei and asymmetric nuclear matter. (orig.)

  18. Atlas of Nuclear Isomers

    Science.gov (United States)

    Jain, Ashok Kumar; Maheshwari, Bhoomika; Garg, Swati; Patial, Monika; Singh, Balraj

    2015-09-01

    We present an atlas of nuclear isomers containing the experimental data for the isomers with a half-life ≥ 10 ns together with their various properties such as excitation-energy, half-life, decay mode(s), spin-parity, energies and multipolarities of emitted gamma transitions, etc. The ENSDF database complemented by the XUNDL database has been extensively used in extracting the relevant data. Recent literature from primary nuclear physics journals, and the NSR bibliographic database have been searched to ensure that the compiled data Table is as complete and current as possible. The data from NUBASE-12 have also been checked for completeness, but as far as possible original references have been cited. Many interesting systematic features of nuclear isomers emerge, some of them new; these are discussed and presented in various graphs and figures. The cutoff date for the extraction of data from the literature is August 15, 2015.

  19. Pediatric nuclear medicine

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    This symposium presented the latest techniques and approaches to the proper medical application of radionuclides in pediatrics. An expert faculty, comprised of specialists in the field of pediatric nuclear medicine, discussed the major indications as well as the advantages and potential hazards of nuclear medicine procedures compared to other diagnostic modalities. In recent years, newer radiopharmaceuticals labeled with technetium-99m and other short-lived radionuclides with relatively favorable radiation characteristics have permitted a variety of diagnostic studies that are very useful clinically and carry a substantially lower radiation burden then many comparable X-ray studies. This new battery of nuclear medicine procedures is now widely available for diagnosis and management of pediatric patients. Many recent research studies in children have yielded data concerning the effacacy of these procedures, and current recommendations will be presented by those involved in conducting such studies. Individual papers are processed separately for the Energy Data Base.

  20. Nuclear cosmo-chronology

    CERN Document Server

    Berkès, I

    2001-01-01

    The nuclear cosmo-chronology is based on radioactive dating which makes use of isotope or element pairs. In this paper we investigate the galaxy age estimations which can be deduced from meteorite analysis and solar or certain old stars light absorption spectra. These evaluations are based on theoretical models different then those implied in cosmology. They imply the calculation of heavy nuclei production in r process. The most significant difficulty of this calculation arises from the necessity of simultaneous evaluation of the production of a large number of nuclei what implies the difficult application of the microscopic nuclear models. Since the solar system is young as compared to the age of galaxy the evaluation based on element abundances (deduced from sun absorption spectra or meteorite analyses) requires a chemical evolution model of the galaxy. So far such an evaluation based on all the pairs of nuclear chronometers was not possible with a single set of parameters. Recent progress in estimating the...

  1. Atlas of Nuclear Isomers

    Energy Technology Data Exchange (ETDEWEB)

    Jain, Ashok Kumar, E-mail: ajainfph@iitr.ac.in [Department of Physics, Indian Institute of Technology, Roorkee-247667 (India); Maheshwari, Bhoomika; Garg, Swati; Patial, Monika [Department of Physics, Indian Institute of Technology, Roorkee-247667 (India); Singh, Balraj [Department of Physics and Astronomy, McMaster University, Hamilton, Ontario-L8S 4M1 (Canada)

    2015-09-15

    We present an atlas of nuclear isomers containing the experimental data for the isomers with a half-life ≥ 10 ns together with their various properties such as excitation-energy, half-life, decay mode(s), spin-parity, energies and multipolarities of emitted gamma transitions, etc. The ENSDF database complemented by the XUNDL database has been extensively used in extracting the relevant data. Recent literature from primary nuclear physics journals, and the NSR bibliographic database have been searched to ensure that the compiled data Table is as complete and current as possible. The data from NUBASE-12 have also been checked for completeness, but as far as possible original references have been cited. Many interesting systematic features of nuclear isomers emerge, some of them new; these are discussed and presented in various graphs and figures. The cutoff date for the extraction of data from the literature is August 15, 2015.

  2. Exotic nuclear excitations

    CERN Document Server

    Pancholi, S C

    2011-01-01

    By providing the reader with a foundational background in high spin nuclear structure physics and exploring exciting current discoveries in the field, this book presents new phenomena in a clear and compelling way. The quest for achieving the highest spin states has resulted in some remarkable successes which this monograph will address in comprehensive detail. The text covers an array of pertinent subject matter, including the rotational alignment and bandcrossings, magnetic rotation, triaxial strong deformation and wobbling motion and chirality in nuclei. Dr. Pancholi offers his readers a clearly-written and up-to-date treatment of the topics covered. The prerequisites for a proper appreciation are courses in nuclear physics and nuclear models and measurement techniques of observables like gamma-ray energies, intensities, multi-fold coincidences, angular correlations or distributions, linear polarization, internal conversion coefficients, short lifetime (pico-second range) of excited states etc. and instrum...

  3. Nuclear reactor neutron shielding

    Science.gov (United States)

    Speaker, Daniel P; Neeley, Gary W; Inman, James B

    2017-09-12

    A nuclear reactor includes a reactor pressure vessel and a nuclear reactor core comprising fissile material disposed in a lower portion of the reactor pressure vessel. The lower portion of the reactor pressure vessel is disposed in a reactor cavity. An annular neutron stop is located at an elevation above the uppermost elevation of the nuclear reactor core. The annular neutron stop comprises neutron absorbing material filling an annular gap between the reactor pressure vessel and the wall of the reactor cavity. The annular neutron stop may comprise an outer neutron stop ring attached to the wall of the reactor cavity, and an inner neutron stop ring attached to the reactor pressure vessel. An excore instrument guide tube penetrates through the annular neutron stop, and a neutron plug comprising neutron absorbing material is disposed in the tube at the penetration through the neutron stop.

  4. Reporting nuclear cardiology

    DEFF Research Database (Denmark)

    Trägårdh, Elin; Hesse, Birger; Knuuti, Juhani

    2015-01-01

    The report of an imaging procedure is a critical component of an examination, being the final and often the only communication from the interpreting physician to the referring or treating physician. Very limited evidence and few recommendations or guidelines on reporting imaging studies...... are available; therefore, an European position statement on how to report nuclear cardiology might be useful. The current paper combines the limited existing evidence with expert consensus, previously published recommendations as well as current clinical practices. For all the applications discussed......, and conclusion of the report. The statement also discusses recommended terminology in nuclear cardiology, image display, and preliminary reports. It is hoped that this statement may lead to more attention to create well-written and standardized nuclear cardiology reports and eventually lead to improved clinical...

  5. The Richness Dependence of Galaxy Cluster Correlations: Results From A Redshift Survey Of Rich APM Clusters

    Science.gov (United States)

    Croft, R. A. C.; Dalton, G. B.; Efstathiou, G.; Sutherland, W. J.; Maddox, S. J.

    1997-01-01

    We analyze the spatial clustering properties of a new catalog of very rich galaxy clusters selected from the APM Galaxy Survey. These clusters are of comparable richness and space density to Abell Richness Class greater than or equal to 1 clusters, but selected using an objective algorithm from a catalog demonstrably free of artificial inhomogeneities. Evaluation of the two-point correlation function xi(sub cc)(r) for the full sample and for richer subsamples reveals that the correlation amplitude is consistent with that measured for lower richness APM clusters and X-ray selected clusters. We apply a maximum likelihood estimator to find the best fitting slope and amplitude of a power law fit to x(sub cc)(r), and to estimate the correlation length r(sub 0) (the value of r at which xi(sub cc)(r) is equal to unity). For clusters with a mean space density of 1.6 x 10(exp -6) h(exp 3) MpC(exp -3) (equivalent to the space density of Abell Richness greater than or equal to 2 clusters), we find r(sub 0) = 21.3(+11.1/-9.3) h(exp -1) Mpc (95% confidence limits). This is consistent with the weak richness dependence of xi(sub cc)(r) expected in Gaussian models of structure formation. In particular, the amplitude of xi(sub cc)(r) at all richnesses matches that of xi(sub cc)(r) for clusters selected in N-Body simulations of a low density Cold Dark Matter model.

  6. Accidents in nuclear ships

    Energy Technology Data Exchange (ETDEWEB)

    Oelgaard, P.L. [Risoe National Lab., Roskilde (Denmark)]|[Technical Univ. of Denmark, Lyngby (Denmark)

    1996-12-01

    This report starts with a discussion of the types of nuclear vessels accidents, in particular accidents which involve the nuclear propulsion systems. Next available information on 61 reported nuclear ship events in considered. Of these 6 deals with U.S. ships, 54 with USSR ships and 1 with a French ship. The ships are in almost all cases nuclear submarines. Only events that involve the sinking of vessels, the nuclear propulsion plants, radiation exposures, fires/explosions, sea-water leaks into the submarines and sinking of vessels are considered. For each event a summary of available information is presented, and comments are added. In some cases the available information is not credible, and these events are neglected. This reduces the number of events to 5 U.S. events, 35 USSR/Russian events and 1 French event. A comparison is made between the reported Soviet accidents and information available on dumped and damaged Soviet naval reactors. It seems possible to obtain good correlation between the two types of events. An analysis is made of the accident and estimates are made of the accident probabilities which are found to be of the order of 10{sup -3} per ship reactor years. It if finally pointed out that the consequences of nuclear ship accidents are fairly local and does in no way not approach the magnitude of the Chernobyl accident. It is emphasized that some of the information on which this report is based, may not be correct. Consequently some of the results of the assessments made may not be correct. (au).

  7. Swedish nuclear waste efforts

    Energy Technology Data Exchange (ETDEWEB)

    Rydberg, J.

    1981-09-01

    After the introduction of a law prohibiting the start-up of any new nuclear power plant until the utility had shown that the waste produced by the plant could be taken care of in an absolutely safe way, the Swedish nuclear utilities in December 1976 embarked on the Nuclear Fuel Safety Project, which in November 1977 presented a first report, Handling of Spent Nuclear Fuel and Final Storage of Vitrified Waste (KBS-I), and in November 1978 a second report, Handling and Final Storage of Unreprocessed Spent Nuclear Fuel (KBS II). These summary reports were supported by 120 technical reports prepared by 450 experts. The project engaged 70 private and governmental institutions at a total cost of US $15 million. The KBS-I and KBS-II reports are summarized in this document, as are also continued waste research efforts carried out by KBS, SKBF, PRAV, ASEA and other Swedish organizations. The KBS reports describe all steps (except reprocessing) in handling chain from removal from a reactor of spent fuel elements until their radioactive waste products are finally disposed of, in canisters, in an underground granite depository. The KBS concept relies on engineered multibarrier systems in combination with final storage in thoroughly investigated stable geologic formations. This report also briefly describes other activities carried out by the nuclear industry, namely, the construction of a central storage facility for spent fuel elements (to be in operation by 1985), a repository for reactor waste (to be in operation by 1988), and an intermediate storage facility for vitrified high-level waste (to be in operation by 1990). The R and D activities are updated to September 1981.

  8. Nuclear War Survival Skills

    Energy Technology Data Exchange (ETDEWEB)

    Kearny, C.H.

    2002-06-24

    The purpose of this book is to provide Americans with information and instructions that will significantly increase their chances of surviving a possible nuclear attack. It brings together field-tested instructions that, if followed by a large fraction of Americans during a crisis that preceded an attack, could save millions of lives. The author is convinced that the vulnerability of our country to nuclear threat or attack must be reduced and that the wide dissemination of the information contained in this book would help achieve that objective of our overall defense strategy.

  9. Translational Molecular Nuclear Cardiology.

    Science.gov (United States)

    Thackeray, James T; Bengel, Frank M

    2016-02-01

    Increased rollout and availability of preclinical imaging provides a foundation for development of novel molecular nuclear imaging agents. The current armamentarium of radiotracers available for nuclear cardiology allows for the interrogation of critical molecular processes involved in a myriad of cardiovascular disorders, including altered metabolism, ventricular remodeling, sympathetic neuronal activation, and systemic inflammation. Effective translational molecular imaging requires coordination of clinical need with tracer development and molecular biology, leading to the identification of ideal translational imaging compounds. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Nuclear reactor effluent monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Minns, J.L.; Essig, T.H. [Nuclear Regulatory Commission, Washington, DC (United States)

    1993-12-31

    Radiological environmental monitoring and effluent monitoring at nuclear power plants is important both for normal operations, as well as in the event of an accident. During normal operations, environmental monitoring verifies the effectiveness of in-plant measures for controlling the release of radioactive materials in the plant. Following an accident, it would be an additional mechanism for estimating doses to members of the general public. This paper identifies the U.S. Nuclear Regulatory Commission (NRC) regulatory basis for requiring radiological environmental and effluent monitoring, licensee conditions for effluent and environmental monitoring, NRC independent oversight activities, and NRC`s program results.

  11. Nuclear Innovation Workshops Report

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, John Howard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Allen, Todd Randall [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hildebrandt, Philip Clay [Idaho National Lab. (INL), Idaho Falls, ID (United States); Baker, Suzanne Hobbs [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    The Nuclear Innovation Workshops were held at six locations across the United States on March 3-5, 2015. The data collected during these workshops has been analyzed and sorted to bring out consistent themes toward enhancing innovation in nuclear energy. These themes include development of a test bed and demonstration platform, improved regulatory processes, improved communications, and increased public-private partnerships. This report contains a discussion of the workshops and resulting themes. Actionable steps are suggested at the end of the report. This revision has a small amount of the data in Appendix C removed in order to avoid potential confusion.

  12. Nuclear war effects studied

    Science.gov (United States)

    Widespread starvation resulting from changes in climate in the aftermath of a large-scale nuclear war could kill far more people than would the bombs themselves. That prediction was made in a recent study by the Scientific Committee on Problems of the Environment (SCOPE), an a rm of the International Council of Scientific Unions (ICSU). “Noncombatant and combatant countries alike” would risk mass starvation; SCOPE predicted that all told, 2.5 billion people could die as a result of crop failures and breakdowns in food distribution after a nuclear war.

  13. Nuclear structure database

    Energy Technology Data Exchange (ETDEWEB)

    Firestone, R.B.; Browne, E.

    1980-06-01

    A nuclear structure database has been created from the Table of Isotopes level-scheme file. This database contains evaluated data (through 1977) on level and deexcitation properties for all known isotopes from radioactive decay and nuclear reaction studies. The data are organized in simple array formats to enable rapid searches for specific level or decay information. Examples of the use of this database to study the properties of first excited J/sup ..pi../ = 2/sup +/ states in even-even nuclei and Weisskopf enhancements of delayed ..gamma..-ray transitions are shown. 6 figures, 3 tables.

  14. Nuclear Chemistry and Services

    Energy Technology Data Exchange (ETDEWEB)

    Vandevelde, L

    2002-04-01

    The objectives, the programme, and the achievements of R and D at the Belgian Nuclear Research Centre SCK-CEN in the field of nuclear chemistry and analytical techniques are summarized. Major achievement in 2001 included the completion of a project on the measurement of critical radionuclides in reactor waste fluxes (the ARIANE project), the radiochemical characterisation of beryllium material originating from the second matrix of the BR2 reactor as well as to a the organisation of a workshop on the analysis of thorium and its isotopes in workplace materials.

  15. Physics in nuclear medicine

    CERN Document Server

    Cherry, Simon R; Phelps, Michael E

    2012-01-01

    Physics in Nuclear Medicine - by Drs. Simon R. Cherry, James A. Sorenson, and Michael E. Phelps - provides current, comprehensive guidance on the physics underlying modern nuclear medicine and imaging using radioactively labeled tracers. This revised and updated fourth edition features a new full-color layout, as well as the latest information on instrumentation and technology. Stay current on crucial developments in hybrid imaging (PET/CT and SPECT/CT), and small animal imaging, and benefit from the new section on tracer kinetic modeling in neuroreceptor imaging.

  16. Friction in nuclear dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Swiatecki, W.J.

    1985-03-01

    The problem of dissipation in nuclear dynamics is related to the breaking down of nuclear symmetries and the transition from ordered to chaotic nucleonic motions. In the two extreme idealizations of the perfectly Ordered Regime and the fully Chaotic Regime, the nucleus should behave as an elastic solid or an overdamped fluid, respectively. In the intermediate regime a complicated visco-elastic behaviour is expected. The discussion is illustrated by a simple estimate of the frequency of the giant quadrupole resonance in the Ordered Regime and by applications of the wall and window dissipation formulae in the Chaotic Regime. 51 refs.

  17. Particle and nuclear physics

    CERN Document Server

    Faessler, Amand

    1971-01-01

    Progress in Particle and Nuclear Physics, Volume 26 covers the significant advances in understanding the fundamentals of particle and nuclear physics. This volume is divided into four chapters, and begins with a brief overview of the various possible ideas beyond the standard model, the problem they address and their experimental tests. The next chapter deals with the basic physics of neutrino mass based on from a gauge theoretic point of view. This chapter considers the various extensions of the standard electroweak theory, along with their implications for neutrino physics. The discussio

  18. Nuclear order in copper

    DEFF Research Database (Denmark)

    Annila, A.J.; Clausen, K.N.; Lindgård, P-A.

    1990-01-01

    A new ordering vector k=(2π/a)(0, 2/3, 2/3) for fcc antiferromagnets has been found by neutron-diffraction experiments at nanokelvin temperatures in the nuclear-spin system of a 65Cu single crystal. The corresponding reflection together with the previously observed (100) Bragg peak show the prese......A new ordering vector k=(2π/a)(0, 2/3, 2/3) for fcc antiferromagnets has been found by neutron-diffraction experiments at nanokelvin temperatures in the nuclear-spin system of a 65Cu single crystal. The corresponding reflection together with the previously observed (100) Bragg peak show...

  19. Nuclear order in copper

    DEFF Research Database (Denmark)

    Annila, A.J.; Clausen, K.N.; Lindgård, P.-A.

    1990-01-01

    The new antiferromagnetic reflection (02/32/3) has been found by neutron diffraction experiments at nanokelvin temperatures in the nuclear spin system of a 65CU single crystal. The corresponding three-sublattice structure has not been observed previously in any fcc antiferromagnet.......The new antiferromagnetic reflection (02/32/3) has been found by neutron diffraction experiments at nanokelvin temperatures in the nuclear spin system of a 65CU single crystal. The corresponding three-sublattice structure has not been observed previously in any fcc antiferromagnet....

  20. Nuclear safety in perspective

    DEFF Research Database (Denmark)

    Andersson, K.; Sjöberg, B.M.D.; Lauridsen, Kurt

    2003-01-01

    The aim of the NKS/SOS-1 project has been to enhance common understanding about requirements for nuclear safety by finding improved means of communicat-ing on the subject in society. The project, which has been built around a number of seminars, wassupported by limited research in three sub......-projects: Risk assessment Safety analysis Strategies for safety management The report describes an industry in change due to societal factors. The concepts of risk and safety, safety management and systems forregulatory oversight are de-scribed in the nuclear area and also, to widen the perspective, for other...

  1. Security culture for nuclear facilities

    Science.gov (United States)

    Gupta, Deeksha; Bajramovic, Edita

    2017-01-01

    Natural radioactive elements are part of our environment and radioactivity is a natural phenomenon. There are numerous beneficial applications of radioactive elements (radioisotopes) and radiation, starting from power generation to usages in medical, industrial and agriculture applications. But the risk of radiation exposure is always attached to operational workers, the public and the environment. Hence, this risk has to be assessed and controlled. The main goal of safety and security measures is to protect human life, health, and the environment. Currently, nuclear security considerations became essential along with nuclear safety as nuclear facilities are facing rapidly increase in cybersecurity risks. Therefore, prevention and adequate protection of nuclear facilities from cyberattacks is the major task. Historically, nuclear safety is well defined by IAEA guidelines while nuclear security is just gradually being addressed by some new guidance, especially the IAEA Nuclear Security Series (NSS), IEC 62645 and some national regulations. At the overall level, IAEA NSS 7 describes nuclear security as deterrence and detection of, and response to, theft, sabotage, unauthorized access, illegal transfer or other malicious acts involving nuclear, other radioactive substances and their associated facilities. Nuclear security should be included throughout nuclear facilities. Proper implementation of a nuclear security culture leads to staff vigilance and a high level of security posture. Nuclear security also depends on policy makers, regulators, managers, individual employees and members of public. Therefore, proper education and security awareness are essential in keeping nuclear facilities safe and secure.

  2. The Potato Nucleotide-binding Leucine-rich Repeat (NLR) Immune Receptor Rx1 Is a Pathogen-dependent DNA-deforming Protein

    NARCIS (Netherlands)

    Fenyk, S.; Townsend, P.D.; Dixon, C.H.; Spies, G.B.; de San Eustaquio Campillo, A.; Slootweg, E.J.; Westerhof, L.B.; Gawehns, F.K.K.; Knight, M.R.; Sharples, G.J.; Goverse, A.; Pålsson, L.O.; Takken, F.L.W.; Cann, M.J.

    2015-01-01

    Plant nucleotide-binding leucine-rich repeat (NLR) proteins enable cells to respond to pathogen attack. Several NLRs act in the nucleus; however, conserved nuclear targets that support their role in immunity are unknown. Previously, we noted a structural homology between the nucleotide-binding

  3. A protein binding AT-rich sequence in the soybean leghemoglobin c3 promoter is a general cis element that requires proximal DNA elements to stimulate transcription

    DEFF Research Database (Denmark)

    Laursen, N B; Larsen, K; Knudsen, J Y

    1994-01-01

    A nodule nuclear factor, NAT2, interacts with two AT-rich binding sites (NAT2 BS1 and NAT2 BS2) in the soybean leghemoglobin (lb) c3 promoter. In transgenic Lotus corniculatus nodules, an oligonucleotide containing NAT2 BS1 activated an inactive -159 lbc3 promoter when placed immediately upstream...

  4. Identification of a putative nuclear export signal motif in human NANOG homeobox domain

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sung-Won; Do, Hyun-Jin; Huh, Sun-Hyung; Sung, Boreum [Department of Biomedical Science, College of Life Science, CHA University, Seongnam-si, Gyeonggi-Do (Korea, Republic of); Uhm, Sang-Jun [Department of Animal Science and Biotechnology, Sangji Youngseo College, Wonju, Gwangwon-Do (Korea, Republic of); Song, Hyuk [Department of Animal and Food Bioscience, College of Natural Science, Konkuk University, ChungJu, Chungbuk (Korea, Republic of); Kim, Nam-Hyung [Department of Animal Sciences, Chungbuk National University, Cheongju, Chungbuk (Korea, Republic of); Kim, Jae-Hwan, E-mail: jaehwan_k@cha.ac.kr [Department of Biomedical Science, College of Life Science, CHA University, Seongnam-si, Gyeonggi-Do (Korea, Republic of)

    2012-05-11

    Highlights: Black-Right-Pointing-Pointer We found the putative nuclear export signal motif within human NANOG homeodomain. Black-Right-Pointing-Pointer Leucine-rich residues are important for human NANOG homeodomain nuclear export. Black-Right-Pointing-Pointer CRM1-specific inhibitor LMB blocked the potent human NANOG NES-mediated nuclear export. -- Abstract: NANOG is a homeobox-containing transcription factor that plays an important role in pluripotent stem cells and tumorigenic cells. To understand how nuclear localization of human NANOG is regulated, the NANOG sequence was examined and a leucine-rich nuclear export signal (NES) motif ({sup 125}MQELSNILNL{sup 134}) was found in the homeodomain (HD). To functionally validate the putative NES motif, deletion and site-directed mutants were fused to an EGFP expression vector and transfected into COS-7 cells, and the localization of the proteins was examined. While hNANOG HD exclusively localized to the nucleus, a mutant with both NLSs deleted and only the putative NES motif contained (hNANOG HD-{Delta}NLSs) was predominantly cytoplasmic, as observed by nucleo/cytoplasmic fractionation and Western blot analysis as well as confocal microscopy. Furthermore, site-directed mutagenesis of the putative NES motif in a partial hNANOG HD only containing either one of the two NLS motifs led to localization in the nucleus, suggesting that the NES motif may play a functional role in nuclear export. Furthermore, CRM1-specific nuclear export inhibitor LMB blocked the hNANOG potent NES-mediated export, suggesting that the leucine-rich motif may function in CRM1-mediated nuclear export of hNANOG. Collectively, a NES motif is present in the hNANOG HD and may be functionally involved in CRM1-mediated nuclear export pathway.

  5. Nuclear science and technology

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-07-01

    The Program on Nuclear Science and Technology comprehends Nuclear and Condensed Matter Physics, Neutron Activation Analysis, Radiation Metrology, Radioprotection and Radioactive Waste Management. These activities are developed at the Research Reactor Center, the Radiation Metrology Center and the Radioactive Waste Management Laboratory. The Radioprotection activities are developed at all radioactive and nuclear facilities of IPEN-CNEN/SP. The Research Reactor Center at IPEN-CNEN/SP is responsible for the operation and maintenance of the Research Reactor IEA-R1 and has a three-fold mission: promoting basic and applied research in nuclear and neutron related sciences, providing educational opportunities for students in these fields and providing services and applications resulting from the reactor utilization. Specific research programs include nuclear structure study from beta and gamma decay of radioactive nuclei and nuclear reactions, nuclear and neutron metrology, neutron diffraction and neutron multiple-diffraction study for crystalline and magnetic structure determination, perturbed -angular correlation (PAC) using radioactive nuclear probes to study the nuclear hyperfine interactions in solids and instrumental neutron activation analysis, with comparative or ko standardization applied to the fields of health, agriculture, environment, archaeology, reference material production, geology and industry. The research in the areas of applied physics includes neutron radiography, scientific computation and nuclear instrumentation. During the last several years a special effort was made to refurbish the old components and systems of the reactor, particularly those related with the reactor safety improvement, in order to upgrade the reactor power. The primary objective was to modernize the IEA-R1 reactor for safe and sustainable operation to produce primary radioisotopes, such as {sup 99}Mo and {sup 131}I, among several others, used in nuclear medicine, by operating

  6. Aluminum Rich Epoxy Primer for Ground and Air Vehicles

    Science.gov (United States)

    2017-03-01

    UNCLASSIFIED DOCUMENT Aluminum Rich Epoxy Primer for Ground and Air Vehicles Monthly Technical Report for the Period: January 20, 2017...Objective: To further develop the Aluminum Rich Epoxy Primer systems for Air and Ground Vehicles while addressing the objective requirements

  7. Reconstruction and calibration strategies for the LHCb RICH detector

    CERN Multimedia

    2006-01-01

    - LHCb particle identification - LHCb ring pattern recognition algorithm requirements - RICH pattern recognition - Cherenkov angle reconstruction online - Online PID - Hough transform - Metropolis- Hastings Markov chains - PID online: physics performances - Rich PID Callibration

  8. Alert status of nuclear weapons

    Science.gov (United States)

    Kristensen, Hans M.

    2017-11-01

    Nuclear Alert Forces. Four nuclear-armed states deploy nuclear warheads on alert, ready to be used on relatively short notice: United States, Russia, France and Britain. Combined, the four countries deploy an estimated 1,869 nuclear alert warheads. Russia and the United States deploy 1,749 alert warheads combined, or 94% of all alert warheads. Despite some debate about possible need to increase readiness of nuclear forces (China, Pakistan), the five other nuclear-armed states (China, Pakistan, India, Israel and North Korea) are thought to store their warheads separate from launchers under normal circumstances. The overall number of alert warheads has remained relatively stable during the past five years.

  9. Nuclear power renaissance or demise?

    Energy Technology Data Exchange (ETDEWEB)

    Dossani, Umair

    2010-09-15

    Nuclear power is going through a renaissance or demise is widely debated around the world keeping in mind the facts that there are risks related to nuclear technology and at the same time that is it environmentally friendly. My part of the argument is that there is no better alternative than Nuclear power. Firstly Nuclear Power in comparison to all other alternative fuels is environmentally sustainable. Second Nuclear power at present is at the dawn of a new era with new designs and technologies. Third part of the debate is renovation in the nuclear fuel production, reprocessing and disposal.

  10. Nuclear astrophysics with radioactive ions at FAIR

    Science.gov (United States)

    Reifarth, R.; Altstadt, S.; Göbel, K.; Heftrich, T.; Heil, M.; Koloczek, A.; Langer, C.; Plag, R.; Pohl, M.; Sonnabend, K.; Weigand, M.; Adachi, T.; Aksouh, F.; Al-Khalili, J.; AlGarawi, M.; AlGhamdi, S.; Alkhazov, G.; Alkhomashi, N.; Alvarez-Pol, H.; Alvarez-Rodriguez, R.; Andreev, V.; Andrei, B.; Atar, L.; Aumann, T.; Avdeichikov, V.; Bacri, C.; Bagchi, S.; Barbieri, C.; Beceiro, S.; Beck, C.; Beinrucker, C.; Belier, G.; Bemmerer, D.; Bendel, M.; Benlliure, J.; Benzoni, G.; Berjillos, R.; Bertini, D.; Bertulani, C.; Bishop, S.; Blasi, N.; Bloch, T.; Blumenfeld, Y.; Bonaccorso, A.; Boretzky, K.; Botvina, A.; Boudard, A.; Boutachkov, P.; Boztosun, I.; Bracco, A.; Brambilla, S.; Briz Monago, J.; Caamano, M.; Caesar, C.; Camera, F.; Casarejos, E.; Catford, W.; Cederkall, J.; Cederwall, B.; Chartier, M.; Chatillon, A.; Cherciu, M.; Chulkov, L.; Coleman-Smith, P.; Cortina-Gil, D.; Crespi, F.; Crespo, R.; Cresswell, J.; Csatlós, M.; Déchery, F.; Davids, B.; Davinson, T.; Derya, V.; Detistov, P.; Diaz Fernandez, P.; DiJulio, D.; Dmitry, S.; Doré, D.; Dueñas, J.; Dupont, E.; Egelhof, P.; Egorova, I.; Elekes, Z.; Enders, J.; Endres, J.; Ershov, S.; Ershova, O.; Fernandez-Dominguez, B.; Fetisov, A.; Fiori, E.; Fomichev, A.; Fonseca, M.; Fraile, L.; Freer, M.; Friese, J.; Borge, M. G.; Galaviz Redondo, D.; Gannon, S.; Garg, U.; Gasparic, I.; Gasques, L.; Gastineau, B.; Geissel, H.; Gernhäuser, R.; Ghosh, T.; Gilbert, M.; Glorius, J.; Golubev, P.; Gorshkov, A.; Gourishetty, A.; Grigorenko, L.; Gulyas, J.; Haiduc, M.; Hammache, F.; Harakeh, M.; Hass, M.; Heine, M.; Hennig, A.; Henriques, A.; Herzberg, R.; Holl, M.; Ignatov, A.; Ignatyuk, A.; Ilieva, S.; Ivanov, M.; Iwasa, N.; Jakobsson, B.; Johansson, H.; Jonson, B.; Joshi, P.; Junghans, A.; Jurado, B.; Körner, G.; Kalantar, N.; Kanungo, R.; Kelic-Heil, A.; Kezzar, K.; Khan, E.; Khanzadeev, A.; Kiselev, O.; Kogimtzis, M.; Körper, D.; Kräckmann, S.; Kröll, T.; Krücken, R.; Krasznahorkay, A.; Kratz, J.; Kresan, D.; Krings, T.; Krumbholz, A.; Krupko, S.; Kulessa, R.; Kumar, S.; Kurz, N.; Kuzmin, E.; Labiche, M.; Langanke, K.; Lazarus, I.; Le Bleis, T.; Lederer, C.; Lemasson, A.; Lemmon, R.; Liberati, V.; Litvinov, Y.; Löher, B.; Lopez Herraiz, J.; Münzenberg, G.; Machado, J.; Maev, E.; Mahata, K.; Mancusi, D.; Marganiec, J.; Martinez Perez, M.; Marusov, V.; Mengoni, D.; Million, B.; Morcelle, V.; Moreno, O.; Movsesyan, A.; Nacher, E.; Najafi, M.; Nakamura, T.; Naqvi, F.; Nikolski, E.; Nilsson, T.; Nociforo, C.; Nolan, P.; Novatsky, B.; Nyman, G.; Ornelas, A.; Palit, R.; Pandit, S.; Panin, V.; Paradela, C.; Parkar, V.; Paschalis, S.; Pawłowski, P.; Perea, A.; Pereira, J.; Petrache, C.; Petri, M.; Pickstone, S.; Pietralla, N.; Pietri, S.; Pivovarov, Y.; Potlog, P.; Prokofiev, A.; Rastrepina, G.; Rauscher, T.; Ribeiro, G.; Ricciardi, M.; Richter, A.; Rigollet, C.; Riisager, K.; Rios, A.; Ritter, C.; Rodriguez Frutos, T.; Rodriguez Vignote, J.; Röder, M.; Romig, C.; Rossi, D.; Roussel-Chomaz, P.; Rout, P.; Roy, S.; Söderström, P.; Saha Sarkar, M.; Sakuta, S.; Salsac, M.; Sampson, J.; Sanchez, J.; Rio Saez, del; Sanchez Rosado, J.; Sanjari, S.; Sarriguren, P.; Sauerwein, A.; Savran, D.; Scheidenberger, C.; Scheit, H.; Schmidt, S.; Schmitt, C.; Schnorrenberger, L.; Schrock, P.; Schwengner, R.; Seddon, D.; Sherrill, B.; Shrivastava, A.; Sidorchuk, S.; Silva, J.; Simon, H.; Simpson, E.; Singh, P.; Slobodan, D.; Sohler, D.; Spieker, M.; Stach, D.; Stan, E.; Stanoiu, M.; Stepantsov, S.; Stevenson, P.; Strieder, F.; Stuhl, L.; Suda, T.; Sümmerer, K.; Streicher, B.; Taieb, J.; Takechi, M.; Tanihata, I.; Taylor, J.; Tengblad, O.; Ter-Akopian, G.; Terashima, S.; Teubig, P.; Thies, R.; Thoennessen, M.; Thomas, T.; Thornhill, J.; Thungstrom, G.; Timar, J.; Togano, Y.; Tomohiro, U.; Tornyi, T.; Tostevin, J.; Townsley, C.; Trautmann, W.; Trivedi, T.; Typel, S.; Uberseder, E.; Udias, J.; Uesaka, T.; Uvarov, L.; Vajta, Z.; Velho, P.; Vikhrov, V.; Volknandt, M.; Volkov, V.; von Neumann-Cosel, P.; von Schmid, M.; Wagner, A.; Wamers, F.; Weick, H.; Wells, D.; Westerberg, L.; Wieland, O.; Wiescher, M.; Wimmer, C.; Wimmer, K.; Winfield, J. S.; Winkel, M.; Woods, P.; Wyss, R.; Yakorev, D.; Yavor, M.; Zamora Cardona, J.; Zartova, I.; Zerguerras, T.; Zgura, M.; Zhdanov, A.; Zhukov, M.; Zieblinski, M.; Zilges, A.; Zuber, K.

    2016-01-01

    The nucleosynthesis of elements beyond iron is dominated by neutron captures in the s and r processes. However, 32 stable, proton-rich isotopes cannot be formed during those processes, because they are shielded from the s-process flow and r-process, β-decay chains. These nuclei are attributed to the p and rp process. For all those processes, current research in nuclear astrophysics addresses the need for more precise reaction data involving radioactive isotopes. Depending on the particular reaction, direct or inverse kinematics, forward or time-reversed direction are investigated to determine or at least to constrain the desired reaction cross sections. The Facility for Antiproton and Ion Research (FAIR) will offer unique, unprecedented opportunities to investigate many of the important reactions. The high yield of radioactive isotopes, even far away from the valley of stability, allows the investigation of isotopes involved in processes as exotic as the r or rp processes.

  11. Key issues in space nuclear power

    Science.gov (United States)

    Brandhorst, Henry W.

    1991-01-01

    The future appears rich in missions that will extend the frontiers of knowledge, human presence in space, and opportunities for profitable commerce. Key to the success of these ventures is the availability of plentiful, cost effective electric power and assured, low cost access to space. While forecasts of space power needs are problematic, an assessment of future needs based on terrestrial experience has been made. These needs fall into three broad categories: survival, self sufficiency, and industrialization. The cost of delivering payloads to orbital locations from LEO to Mars has been determined and future launch cost reductions projected. From these factors, then, projections of the performance necessary for future solar and nuclear space power options has been made. These goals are largely dependent upon orbital location and energy storage needs. Finally the cost of present space power systems has been determined and projections made for future systems.

  12. Nuclear envelope and nuclear matrix: interactions and dynamics.

    Science.gov (United States)

    Vlcek, S; Dechat, T; Foisner, R

    2001-11-01

    The peripheral nuclear lamina is located near the nuclear inner membrane and consists of lamin filaments and integral membrane proteins, including the lamin B receptor and various isoforms of lamina-associated polypeptides (LAP) 1 and 2. Several nuclear membrane proteins also interact with chromatin proteins BAF and Hp1. Lamins in the nuclear interior associate with at least one soluble (non-membrane-bound) LAP2 isoform named LAP2alpha. The internal lamins, together with Tpr-based filaments that connect to nuclear pore complexes, are proposed to be major structural elements of the internal nuclear matrix. We describe the structural links between the peripheral lamina and the internal nuclear matrix that are thought to be mediated by LAP2 family members, filament protein Tpr and nucleoporin Nup153. These findings are discussed in relation to human diseases that arise from mutations in nuclear lamina proteins.

  13. COMPASS mirror wall of RICH 1

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    The COMPASS experiment uses ring imaging Cherenkov (RICH) counters to identify particles produced in high-energy muon collisions, to better understand the spin structure of the nucleon. Charged particles moving faster than the speed of light in the medium through which they are travelling emit a cone of Cherenkov radiation in the direction of their motion. The light in this cone is reflected from these mirrors onto a photo detector so that the size of the cone can be measured, which gives the energy of the particle.

  14. HTML5 Designing Rich Internet Applications

    CERN Document Server

    David, Matthew

    2010-01-01

    Implement the powerful new multimedia and interactive capabilities offered by HTML5, including style control tools, illustration tools, video, audio, and rich media solutions. Understand how HTML5 is changing the Web development game with this full-color, project-based treatment that shows you-not just tells you-what HTML5 can do for your Web sites. Reinforce your practical understanding of the new standard with demo applications and tutorials, so that execution is one short step away. The companion website, visualizetheweb.com, is packed full of extra information, online code libraries, and

  15. Platelet-rich plasma in regenerative medicine

    Directory of Open Access Journals (Sweden)

    Guhta Ra Hara and Thaha Basu

    2014-01-01

    Full Text Available Platelet-rich plasma (PRP contains at least seven growth factors including epidermal, plateletderived, transforming, vascular endothelial, fibroblast, insulin-like and keratinocyte growth factor. The therapeutic effect of PRP occurs because of the high concentration of these growth factors compared with those found in normal plasma. In recent years, PRP is widely used across many clinical fields, especially in regenerative medicine. This review aimed at presenting an overview of the applications of PRP in regenerative medicine. The mechanisms of PRP effects on healing are also stated in this review. [Biomed Res Ther 2014; 1(1.000: 25-31

  16. Computing support for information-rich laparoscopy.

    Science.gov (United States)

    Seales, W Brent; Clarke, Duncan

    2005-12-01

    Developments in the architecture and organization of high-performance general-purpose computer systems are largely ignored by the technology infrastructure of the modern laparoscopic surgical suite. The current state of technology for laparoscopy is a camera and monitor linked via a controller that distributes analog or digital video signals without regard to their content. This article discusses the opportunities that will be created by inserting general-purpose high-performance computing into the information stream between camera and display. We envision that the use of this technology will radically transform laparoscopy from its current state as ;;surgery by pictures'' into an entirely new, information-rich surgical environment.

  17. Development of a Rich Picture editor

    DEFF Research Database (Denmark)

    Valente, Andrea; Marchetti, Emanuela

    2010-01-01

    This paper describes the development of a software tool to support rich pictures creation for object-oriented analysis. This software should be useful both as an e-learning tool for bachelor-level students, as well as for practitioners working with agile methodologies. The transposition of manual...... us in the design of the tool next version. At a more general level we realized that modern object-oriented development methodologies, such as agile methods, are informed by design, hence they sometimes assume design skills that programmers do not have or do not value....

  18. Mars: A water-rich planet

    Science.gov (United States)

    Carr, Michael H.

    1987-01-01

    Good geomorphic evidence is presented for a planet that was once water rich, and that a lower limit on the amount of water available for a given Martian watershed may be estimated by assuming that the volume of material eroded was equal to the volume of water available. This estimate, coupled with high latitude water estimates of 50 to 100 m gives a global inventory of about 500 m total water in the subsurface. It was emphasized that this is a lower limit as considerable water may be bound in weathered debris and in primary minerals.

  19. A Water Rich Mars Surface Mission Scenario

    Science.gov (United States)

    Hoffman, Stephen J.; Andrews, Alida; Joosten, B. Kent; Watts, Kevin

    2017-01-01

    In an on-going effort to make human Mars missions more affordable and sustainable, NASA continues to investigate the innovative leveraging of technological advances in conjunction with the use of accessible Martian resources directly applicable to these missions. One of the resources with the broadest utility for human missions is water. Many past studies of human Mars missions assumed a complete lack of water derivable from local sources. However, recent advances in our understanding of the Martian environment provides growing evidence that Mars may be more "water rich" than previously suspected. This is based on data indicating that substantial quantities of water are mixed with surface regolith, bound in minerals located at or near the surface, and buried in large glacier-like forms. This paper describes an assessment of what could be done in a "water rich" human Mars mission scenario. A description of what is meant by "water rich" in this context is provided, including a quantification of the water that would be used by crews in this scenario. The different types of potential feedstock that could be used to generate these quantities of water are described, drawing on the most recently available assessments of data being returned from Mars. This paper specifically focuses on sources that appear to be buried quantities of water ice. (An assessment of other potential feedstock materials is documented in another paper.) Technologies and processes currently used in terrestrial Polar Regions are reviewed. One process with a long history of use on Earth and with potential application on Mars - the Rodriguez Well - is described and results of an analysis simulating the performance of such a well on Mars are presented. These results indicate that a Rodriguez Well capable of producing the quantities of water identified for a "water rich" human mission are within the capabilities assumed to be available on the Martian surface, as envisioned in other comparable Evolvable

  20. Modeling a neutron rich nuclei source

    Energy Technology Data Exchange (ETDEWEB)

    Mirea, M.; Bajeat, O.; Clapier, F.; Ibrahim, F.; Mueller, A.C.; Pauwels, N.; Proust, J. [Institut de Physique Nucleaire, IN2P3/CNRS, 91 - Orsay (France); Mirea, M. [Institute of Physics and Nuclear Engineering, Tandem Lab., Bucharest (Romania)

    2000-07-01

    The deuteron break-up process in a suitable converter gives rise to intense neutron beams. A source of neutron rich nuclei based on the neutron induced fission can be realised using these beams. A theoretical optimization of such a facility as a function of the incident deuteron energy is reported. The model used to determine the fission products takes into account the excitation energy of the target nucleus and the evaporation of prompt neutrons. Results are presented in connection with a converter-target specific geometry. (author000.

  1. Un contenu riche et diversifié

    Directory of Open Access Journals (Sweden)

    Esther Cloutier

    2010-05-01

    Full Text Available Bonjour,Nous sommes très heureux de vous convier à lire ce nouveau numéro de notre revue. Son contenu est riche et diversifié. Plusieurs thèmes sont abordés : la santé et la sécurité du travail dans les petites entreprises, l’autoévaluation du stress au travail, une démarche ergonomique de transformation du contexte d’intervention, les risques routiers professionnels des conducteurs de travaux, un outil de gestion du sommeil, ainsi que les facteurs socioculturels et TMS. En premier lieu, un a...

  2. Nuclear Security Futures Scenarios.

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Elizabeth James Kistin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Warren, Drake Edward [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hayden, Nancy Kay [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Passell, Howard D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Malczynski, Leonard A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Backus, George A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-01-01

    This report provides an overview of the scenarios used in strategic futures workshops conducted at Sandia on September 21 and 29, 2016. The workshops, designed and facilitated by analysts in Center 100, used scenarios to enable thought leaders to think collectively about the changing aspects of global nuclear security and the potential implications for the US Government and Sandia National Laboratories.

  3. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... centers, nuclear medicine images can be superimposed with computed tomography (CT) or magnetic resonance imaging (MRI) to produce ... addition, manufacturers are now making single photon emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/ ...

  4. Beloyarsk Nuclear Power Plant

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    The Beloyarsk Nuclear Power Plant (BNPP) is located in Zarechny, approximately 60 km east of Ekaterinberg along the Trans-Siberian Highway. Zarechny, a small city of approximately 30,000 residents, was built to support BNPP operations. It is a closed city to unescorted visitors. Residents must show identification for entry. BNPP is one of the first and oldest commercial nuclear power plants in Russia and began operations in 1964. As for most nuclear power plants in the Russian Federation, BNPP is operated by Rosenergoatom, which is subordinated to the Ministry of Atomic Energy of the Russian Federation (Minatom). BNPP is the site of three nuclear reactors, Units 1, 2, and 3. Units 1 and 2, which have been shut-down and defueled, were graphite moderated reactors. The units were shut-down in 1981 and 1989. Unit 3, a BN-600 reactor, is a 600 MW(electric) sodium-cooled fast breeder reactor. Unit 3 went on-line in April 1980 and produces electric power which is fed into a distribution grid and thermal power which provides heat to Zarechny. The paper also discusses the SF NIKIET, the Sverdiovsk Branch of NIKIET, Moscow, which is the research and development branch of the parent NIKEIT and is primarily a design institute responsible for reactor design. Central to its operations is a 15 megawatt IVV research reactor. The paper discusses general security and fissile material control and accountability at these two facilities.

  5. Subcritical nuclear assembly

    Energy Technology Data Exchange (ETDEWEB)

    Vega C, H. R., E-mail: fermineutron@yahoo.com [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)

    2014-08-15

    A Subcritical Nuclear Assembly is a device where the nuclear-fission chain reaction is initiated and maintained using an external neutron source. It is a valuable educational and research tool where in a safe way many reactor parameters can be measured. Here, we have used the Wigner-Seitz method in the six-factor formula to calculate the effective multiplication factor of a subcritical nuclear reactor Nuclear Chicago model 9000. This reactor has approximately 2500 kg of natural uranium heterogeneously distributed in slugs. The reactor uses a {sup 239}PuBe neutron source that is located in the center of an hexagonal array. Using Monte Carlo methods, with the MCNP5 code, a three-dimensional model of the subcritical reactor was designed to estimate the effective multiplication factor, the neutron spectra, the total and thermal neutron fluences along the radial and axial axis. With the neutron spectra in two locations outside the reactor the ambient dose equivalent were estimated. (Author)

  6. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... your child’s recent illnesses, medical conditions, medications and allergies. Depending on the type of exam, your doctor will instruct you on ... supplements and if he or she has any allergies. Also inform your doctor of any recent ... on the type of nuclear scan being performed, you will receive ...

  7. Nuclear Reactors and Technology

    Energy Technology Data Exchange (ETDEWEB)

    Cason, D.L.; Hicks, S.C. [eds.

    1992-01-01

    This publication Nuclear Reactors and Technology (NRT) announces on a monthly basis the current worldwide information available from the open literature on nuclear reactors and technology, including all aspects of power reactors, components and accessories, fuel elements, control systems, and materials. This publication contains the abstracts of DOE reports, journal articles, conference papers, patents, theses, and monographs added to the Energy Science and Technology Database during the past month. Also included are US information obtained through acquisition programs or interagency agreements and international information obtained through the International Energy Agency`s Energy Technology Data Exchange or government-to-government agreements. The digests in NRT and other citations to information on nuclear reactors back to 1948 are available for online searching and retrieval on the Energy Science and Technology Database and Nuclear Science Abstracts (NSA) database. Current information, added daily to the Energy Science and Technology Database, is available to DOE and its contractors through the DOE Integrated Technical Information System. Customized profiles can be developed to provide current information to meet each user`s needs.

  8. Nuclear Fuel Cycle; (USA)

    Energy Technology Data Exchange (ETDEWEB)

    Cason, D.L.; Hicks, S.C. (eds.)

    1991-01-01

    Nuclear Fuel Cycle (NFC) announces on a monthly basis the current worldwide information available from the open literature on all aspects of the fuel cycle except in-reactor properties and performance of fuels. More information related to radioactive waste and to the transport and storage of spent fuel is included in the current awareness publication, Radioactive Waste Management. This publication contains the abstracts of DOE reports, journal articles, conference papers, patents, theses, and monographs added to the Energy Science and Technology Database (EDB) during the past month. Also included are other US information obtained through acquisition programs or interagency agreements and international information obtained through the International Energy Agency's Technology Data Exchange, the International Atomic Energy Agency's International Nuclear Information System, or government-to-government agreements. The digests in NFC on nuclear fuel back to 1948 are available for online searching and retrieval in EDB and Nuclear Science Abstracts (NSA) database. Current information, added daily to EDB, is available to DOE and its contractors through the DOE Integrated Technical Information System. Customized profiles can be developed to provide current information to meet each user's needs.

  9. Nuclear Spin Relaxation

    Indian Academy of Sciences (India)

    IAS Admin

    and almost completely destroyed by the chaotic thermal environ- ment. Fortunately, the havoc wreaked by thermal molecular motion is not complete. The tiny residual nuclear magnetism (of the order of 10–5), which is established through spin–lattice relaxation, is the basis of almost all NMR and MRI experiments. [1].

  10. Nuclear Magnetic Resonance

    Indian Academy of Sciences (India)

    IAS Admin

    This article summarizes the early history of nuclear magnetic resonance (NMR) during the first 25–30 years. The method- ology went through vigorous growth and development during this time, laying the theoretical basis for understanding a wide array of applications. The stage was set for the breath- taking advances the ...

  11. Preserving Nuclear Grade Knowledge

    Energy Technology Data Exchange (ETDEWEB)

    Lange, Bob

    2008-02-05

    When people think of the government they think of the President, or Congress, or the Internal Revenue Service (IRS), but there are thousands of people in government-related jobs doing things most don’t really notice everyday. You can find them everywhere, from the space science folks at NASA, to the Federal Bureau of Investigations (FBI) watching out for the bad guys. There are Rangers, and Social Workers, Nurses and Agricultural Managers. They are people working to keep the many facets of the USA rolling. One very diverse bunch is The Department of Energy (DOE) , a group who is expanding the ways we make and save energy to power our cars, homes, and businesses. Tucked away under the DOE is the National Nuclear Security Administration, the NNSA is an agency that maintains the safety, security, and reliability of the U.S. nuclear weapons stockpile. It works to reduce global danger from weapons of mass destruction. It provides the U.S. Navy with safe nuclear propulsion, and it responds to nuclear and radiological emergencies in the United States and abroad, and it supports efforts in science and technology*. (* DOE/NNSA/KCP website info)

  12. Second Nuclear Era

    Energy Technology Data Exchange (ETDEWEB)

    Weinberg, A.M.; Spiewak, I.; Barkenbus, J.N.; Livingston, R.S.; Phung, D.L.

    1984-03-01

    The Institute for Energy Analysis with support from The Andrew W. Mellon Foundation has studied the decline of the present nuclear era in the United States and the characteristics of a Second Nuclear Era which might be instrumental in restoring nuclear power to an appropriate place in the energy options of our country. The study has determined that reactors operating today are much safer than they were at the time of the TMI accident. A number of concepts for a supersafe reactor were reviewed and at least two were found that show considerable promise, the PIUS, a Swedish pressurized water design, and a gas-cooled modular design of German and US origin. Although new, safer, incrementally improved, conventional reactors are under study by the nuclear industry, the complete lack of new orders in the United States will slow their introduction and they are likely to be more expensive than present designs. The study recommends that supersafe reactors be taken seriously and that federal and private funds both be used to design and, if feasible, to build a prototype reactor of substantial size. 146 references, 8 figures, 2 tables.

  13. Lasers with nuclear pumping

    CERN Document Server

    Melnikov, S P; Sizov, A N; Miley, George H

    2015-01-01

    This book covers the history of lasers with nuclear pumping (Nuclear Pumped Lasers, NPLs). This book showcases the most important results and stages of NPL development in The Russian Federal Nuclear Center (VNIIEF) as well as other Russian and international laboratories, including laboratories in the United States. The basic science and technology behind NPLs along with potential applications are covered throughout the book. As such, this book: ·         Contains a historical overview of the extensive information developed over the past 40 years of work on NPLs ·         Covers the most important results and stages of NPL development, not just in the Russian Federal Nuclear Center, VNIIEF, but also in other laboratories in Russia, the United States , and some other scattered international laboratories ·         Systematizes the fragmented information accumulated over these years of very active research and development As the first comprehensive discussion of NPLs, students, research...

  14. Children's (Pediatric) Nuclear Medicine

    Medline Plus

    Full Text Available ... be followed after leaving the nuclear medicine facility. Through the natural process of radioactive decay, the small amount of radiotracer in your child’s body will lose its radioactivity over time. In many cases, the radioactivity will dissipate over ...

  15. Solitons in nuclear matter

    Energy Technology Data Exchange (ETDEWEB)

    Kurilkin, N.N.; Mishustin, I.N.; Khodel' , V.A.

    1979-10-05

    The propagation of finite-amplitude waves in cold nuclear matter is investigated. It is shown that by taking into account the nonlinear terms in the equations for the Fermi-liquid theory, we obtain elongated wave-soliton-type solutions.

  16. Nuclear waste solutions

    Science.gov (United States)

    Walker, Darrel D.; Ebra, Martha A.

    1987-01-01

    High efficiency removal of technetium values from a nuclear waste stream is achieved by addition to the waste stream of a precipitant contributing tetraphenylphosphonium cation, such that a substantial portion of the technetium values are precipitated as an insoluble pertechnetate salt.

  17. Nuclear testing: Executive summary

    Energy Technology Data Exchange (ETDEWEB)

    Drell, S.; Cornwall, J.; Dyson, F. [and others

    1995-08-01

    The authors have examined the experimental and analytic bases for understanding the performance of each of the weapon types that are currently planned to remain in the US enduring nuclear stockpile. They have also examined whether continued underground tests at various nuclear yield thresholds would add significantly to the confidence in this stockpile in the years ahead. The starting point for this examination was a detailed review of past experience in developing and testing modern nuclear weapons, their certification and recertification processes, their performance margins, and evidence of aging or other trends over time for each weapon type in the enduring stockpile. The findings, as summarized in Conclusions 1 through 6, are consistent with US agreement to enter into a Comprehensive Test Ban Treaty (CTBT) of unending duration, that includes a standard ``supreme national interest`` clause. Recognizing that the challenge of maintaining an effective nuclear stockpile for an indefinite period without benefit of underground tests is an important and also a new one, the US should affirm its readiness to invoke the supreme national interest clause should the need arise as a result of unanticipated technical problems in the enduring stockpile.

  18. Space Nuclear Reactor Engineering

    Energy Technology Data Exchange (ETDEWEB)

    Poston, David Irvin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-03-06

    We needed to find a space reactor concept that could be attractive to NASA for flight and proven with a rapid turnaround, low-cost nuclear test. Heat-pipe-cooled reactors coupled to Stirling engines long identified as the easiest path to near-term, low-cost concept.

  19. Topics in nuclear power

    Science.gov (United States)

    Budnitz, Robert J.

    2015-03-01

    The 101 nuclear plants operating in the US today are far safer than they were 20-30 years ago. For example, there's been about a 100-fold reduction in the occurrence of "significant events" since the late 1970s. Although the youngest of currently operating US plants was designed in the 1970s, all have been significantly modified over the years. Key contributors to the safety gains are a vigilant culture, much improved equipment reliability, greatly improved training of operators and maintenance workers, worldwide sharing of experience, and the effective use of probabilistic risk assessment. Several manufacturers have submitted high quality new designs for large reactors to the U.S. Nuclear Regulatory Commission (NRC) for design approval, and several companies are vigorously working on designs for smaller, modular reactors. Although the Fukushima reactor accident in March 2011 in Japan has been an almost unmitigated disaster for the local population due to their being displaced from their homes and workplaces and also due to the land contamination, its "lessons learned" have been important for the broader nuclear industry, and will surely result in safer nuclear plants worldwide - indeed, have already done so, with more safety improvements to come.

  20. Nuclear rocket engine reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lanin, Anatoly

    2013-07-01

    Covers a new technology of nuclear reactors and the related materials aspects. Integrates physics, materials science and engineering Serves as a basic book for nuclear engineers and nuclear physicists. The development of a nuclear rocket engine reactor (NRER) is presented in this book. The working capacity of an active zone NRER under mechanical and thermal load, intensive neutron fluxes, high energy generation (up to 30 MBT/l) in a working medium (hydrogen) at temperatures up to 3100 K is displayed. Design principles and bearing capacity of reactors area discussed on the basis of simulation experiments and test data of a prototype reactor. Property data of dense constructional, porous thermal insulating and fuel materials like carbide and uranium carbide compounds in the temperatures interval 300 - 3000 K are presented. Technological aspects of strength and thermal strength resistance of materials are considered. The design procedure of possible emergency processes in the NRER is developed and risks for their origination are evaluated. Prospects of the NRER development for pilotless space devices and piloted interplanetary ships are viewed.