Huang, Pengxiang; Nedelcu, Daniel; Watanabe, Miyako; Jao, Cindy; Kim, Youngchang; Liu, Jing; Salic, Adrian
In vertebrates, sterols are necessary for Hedgehog signaling, a pathway critical in embryogenesis and cancer. Sterols activate the membrane protein Smoothened by binding its extracellular, cysteine-rich domain (CRD). Major unanswered questions concern the nature of the endogenous, activating sterol and the mechanism by which it regulates Smoothened. We report crystal structures of CRD complexed with sterols and alone, revealing that sterols induce a dramatic conformational change of the binding site, which is sufficient for Smoothened activation and is unique among CRD-containing receptors. We demonstrate that Hedgehog signaling requires sterol binding to Smoothened and define key residues for sterol recognition and activity. We also show that cholesterol itself binds and activates Smoothened. Furthermore, the effect of oxysterols is abolished in Smoothened mutants that retain activation by cholesterol and Hedgehog. We propose that the endogenous Smoothened activator is cholesterol, not oxysterols, and that vertebrate Hedgehog signaling controls Smoothened by regulating its access to cholesterol.
Full Text Available A variety of reference models such as CMMI, COBIT or ITIL support IT organizations to improve their processes. These process improvement reference models (IRMs cover different domains such as IT development, IT Services or IT Governance but also share some similarities. As there are organizations that address multiple domains and need to coordinate their processes in their improvement we present MoSaIC, an approach to support organizations to efficiently adopt and conform to multiple IRMs. Our solution realizes a semantic integration of IRMs based on common meta-models. The resulting IRM integration model enables organizations to efficiently implement and asses multiple IRMs and to benefit from synergy effects.
... adopted to want to know more about their birth history. Usually a big question is why the birth ... of people want to know about their health history. When people are curious about their birth family, it doesn't mean they don't ...
Jensen, Meiko; Schwenk, Jörg; Bohli, Jens Matthias
Clouds impose new security challenges, which are amongst the biggest obstacles when considering the usage of cloud services. This triggered a lot of research activities in this direction, resulting in a quantity of proposals targeting the various security threats. Besides the security issues coming...... with the cloud paradigm, it can also provide a new set of unique features which open the path towards novel security approaches, techniques and architectures. This paper initiates this discussion by contributing a concept which achieves security merits by making use of multiple distinct clouds at the same time....
Torosyan, Hayarpi; Parathaman, Pranavan; Irwin, John J.; Shoichet, Brian K.
The seven transmembrane protein Smoothened is required for Hedgehog signaling during embryonic development and adult tissue homeostasis. Inappropriate activation of the Hedgehog signalling pathway leads to cancers such as basal cell carcinoma and medulloblastoma, and Smoothened inhibitors are now available clinically to treat these diseases. However, resistance to these inhibitors rapidly develops thereby limiting their efficacy. The determination of Smoothened crystal structures enables structure-based discovery of new ligands with new chemotypes that will be critical to combat resistance. In this study, we docked 3.2 million available, lead-like molecules against Smoothened, looking for those with high physical complementarity to its structure; this represents the first such campaign against the class Frizzled G-protein coupled receptor family. Twenty-one high-ranking compounds were selected for experimental testing, and four, representing three different chemotypes, were identified to antagonize Smoothened with IC50 values better than 50 μM. A screen for analogs revealed another six molecules, with IC50 values in the low micromolar range. Importantly, one of the most active of the new antagonists continued to be efficacious at the D473H mutant of Smoothened, which confers clinical resistance to the antagonist vismodegib in cancer treatment. PMID:27490099
Peluso, Marisa O; Campbell, Veronica T; Harari, Joseph A; Tibbitts, Thomas T; Proctor, Jennifer L; Whitebread, Nigel; Conley, James M; White, Kerry F; Kutok, Jeffery L; Read, Margaret A; McGovern, Karen; Faia, Kerrie L
A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several Smo antagonists are being assessed clinically, one of which is approved for the treatment of advanced basal cell carcinoma. Recent reports demonstrate that various Smo antagonists differentially impact Smo localization to the PC while still exerting inhibitory activity. In contrast to other synthetic small molecule Smo antagonists, the natural product cyclopamine binds to and promotes ciliary accumulation of Smo and "primes" cells for Hh pathway hyper-responsiveness after compound withdrawal. We compared the properties of IPI-926, a semi-synthetic cyclopamine analog, to cyclopamine with regard to potency, ciliary Smo accumulation, and Hh pathway activity after compound withdrawal. Like cyclopamine, IPI-926 promoted accumulation of Smo to the PC. However, in contrast to cyclopamine, IPI-926 treatment did not prime cells for hyper-responsiveness to Shh stimulation after compound withdrawal, but instead demonstrated continuous inhibition of signaling. By comparing the levels of drug-induced ciliary Smo accumulation with the degree of Hh pathway activity after compound withdrawal, we propose that a critical threshold of ciliary Smo is necessary for "priming" activity to occur. This "priming" appears achievable with cyclopamine, but not IPI-926, and is cell-line dependent. Additionally, IPI-926 activity was evaluated in a murine tumor xenograft model and a pharmacokinetic/pharmacodynamic relationship was examined to assess for in vivo evidence of Hh pathway hyper-responsiveness. Plasma concentrations of IPI-926 correlated with the degree and duration of Hh pathway suppression, and pathway activity did not exceed baseline levels out to 96 hours post dose. The overall findings suggest that IPI-926 possesses unique biophysical
Pandit, Tanushree; Ogden, Stacey K.
The Sonic Hedgehog (Shh) signaling pathway is active during embryonic development in metazoans, and provides instructional cues necessary for proper tissue patterning. The pathway signal transducing component, Smoothened (Smo), is a G protein-coupled receptor (GPCR) that has been demonstrated to signal through at least two effector routes. The first is a G protein–independent canonical route that signals to Gli transcriptional effectors to establish transcriptional programs specifying cell fa...
Full Text Available Gingival recession related to periodontal disease or developmental problems can result in root sensitivity, root caries, and esthetically unacceptable root exposures. In the past, multiple surgical procedures have been proposed to obtain root coverage on exposed buccal root surfaces. There has been great interest in the treatment of gingival recession defects, especially with subepithelial connective-tissue grafting (SCTG. Recent advances have focused on SCTG by the tunnel technique. This article highlights the esthetic results obtained by adopting a modification of the tunnel technique using a single vertical incision along with autologous SCTG in the management of multiple adjacent Miller Class-II gingival recessions. A single vertical incision was used along with tunnel preparation for the facile placement of SCTG into the prepared tunnel. After 6 months of follow-up, the clinical condition was stable with satisfactory root coverage outcome. An excellent esthetical outcome was achieved and the patient was satisfied with the result.
Reshi, Bilal Ahmad; Kumar, Shyam; Kartha, Moses J.; Varma, Raghava
We have carried out a detailed study of the growth dynamics of the diamond film during initial time on diamond substrates. The diamond films are deposited using Microwave Plasma Chemical Vapor Deposition (MPCVD) method for different times. Surface morphology and its correlation with the number of hours of growth of thin films was invested using atomic force microscopy (AFM). Diamond films have smooth interface with average roughness of 48.6873nm. The initial growth dynamics of the thin film is investigated. Interestingly, it is found that there is a decrease in the surface roughness of the film. Thus a smoothening effect is observed in the grown films. The film enters into the growth regime in the later times. Our results also find application in building diamond detector.
Pandit, Tanushree; Ogden, Stacey K
The Sonic Hedgehog (Shh) signaling pathway is active during embryonic development in metazoans, and provides instructional cues necessary for proper tissue patterning. The pathway signal transducing component, Smoothened (Smo), is a G protein-coupled receptor (GPCR) that has been demonstrated to signal through at least two effector routes. The first is a G protein-independent canonical route that signals to Gli transcriptional effectors to establish transcriptional programs specifying cell fate during early embryonic development. The second, commonly referred to as the noncanonical Smo signal, induces rapid, transcription-independent responses that are essential for establishing and maintaining distinct cell behaviors during development. Herein, we discuss contributions of this noncanonical route during embryonic development. We also highlight important open questions regarding noncanonical Smo signal route selection during development, and consider implications of noncanonical signal corruption in disease.
Full Text Available The Sonic Hedgehog (Shh signaling pathway is active during embryonic development in metazoans, and provides instructional cues necessary for proper tissue patterning. The pathway signal transducing component, Smoothened (Smo, is a G protein-coupled receptor (GPCR that has been demonstrated to signal through at least two effector routes. The first is a G protein–independent canonical route that signals to Gli transcriptional effectors to establish transcriptional programs specifying cell fate during early embryonic development. The second, commonly referred to as the noncanonical Smo signal, induces rapid, transcription-independent responses that are essential for establishing and maintaining distinct cell behaviors during development. Herein, we discuss contributions of this noncanonical route during embryonic development. We also highlight important open questions regarding noncanonical Smo signal route selection during development, and consider implications of noncanonical signal corruption in disease.
Full Text Available Tara L Lin1, William Matsui21Division of Hematology/Oncology, Department of Internal Medicine, University of Kansas, Kansas City, MO, USA; 2Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USAAbstract: Emerging laboratory and clinical investigations demonstrate that Hedgehog signaling (Hh represents a novel therapeutic target in various human cancers. This conserved signaling pathway precisely regulates self-renewal and terminal differentiation in embryonic development, but is typically silenced in adult tissues, with reactivation usually only during tissue repair. Aberrant Hh pathway signaling has been implicated in the pathogenesis, self-renewal, and chemotherapy resistance of a growing number of solid and hematologic malignancies. Major components of the Hh pathway include the Hh ligands (Sonic, Desert, and Indian, the transmembrane receptor Patched, the signal transducer Smoothened (Smo, and transcription factors Gli1–3 which regulate the transcription of Hh target genes. Mutations in Hh pathway genes, increased Hh signaling in tumor stroma, and Hh overexpression in self-renewing cells (cancer stem cells have been described, and these different modes of Hh signaling have implications for the design of Hh pathway inhibitors and their integration into conventional treatment regimens. Discovery of a naturally-occurring Smo inhibitor, cyclopamine, and the identification of Hh pathway mutations and over expression in cancer cells prompted the development of several cyclopamine derivatives. Encouraging laboratory and in vivo data has resulted in Phase I and II clinical trials of Smo inhibitors. In this review, we will discuss the current understanding of Hh pathway signaling in malignancy and Smo antagonists in development. Recent data with these agents shows that they are well-tolerated and may be effective for subsets of patients. Challenges remain
Olstad, Dana Lee; Raine, Kim D; McCargar, Linda J
Recreational facilities are an important community resource for health promotion because they provide access to affordable physical activities. However, despite their health mandate, many have unhealthy food environments that may paradoxically increase the risk of childhood obesity. The Alberta Nutrition Guidelines for Children and Youth (ANGCY) are government-initiated, voluntary guidelines intended to facilitate children's access to healthy food and beverage choices in schools, childcare and recreational facilities, however few recreational facilities are using them. We used mixed methods within an exploratory multiple case study to examine factors that influenced adoption and implementation of the ANGCY and the nature of the food environment within three cases: an adopter, a semi-adopter and a non-adopter of the ANGCY. Diffusion of Innovations theory provided the theoretical platform for the study. Qualitative data were generated through interviews, observations, and document reviews, and were analysed using directed content analysis. Set theoretic logic was used to identify factors that differentiated adopters from the non-adopter. Quantitative sales data were also collected, and the quality of the food environment was scored using four complementary tools. The keys to adoption and implementation of nutrition guidelines in recreational facilities related to the managers' nutrition-related knowledge, beliefs and perceptions, as these shaped his decisions and actions. The manager, however, could not accomplish adoption and implementation alone. Intersectoral linkages with schools and formal, health promoting partnerships with industry were also important for adoption and implementation to occur. The food environment in facilities that had adopted the ANGCY did not appear to be superior to the food environment in facilities that had not adopted the ANGCY. ANGCY uptake may continue to falter under the current voluntary approach, as the environmental supports for
Burrow, Anthony L; Finley, Gordon E
Using a multimeasure approach, the current study investigated 12 indices of academic, familial, psychological, and health outcomes for 4 groups of transracial and same-race adopted adolescents. A secondary analysis of the National Longitudinal Study of Adolescent Health data showed that Asian adolescents adopted by White parents had both the highest grades and the highest levels of psychosomatic symptoms, whereas Black adolescents adopted by Black parents reported the highest levels of depression. Intriguingly, and by contrast, Black adoptees reported higher levels of self-worth than non-Black adoptees. The implications of the findings for future investigations of transracial adoption are discussed. ((c) 2004 APA, all rights reserved).
Du, J; Fan, Z; Ma, X; Wu, Y; Liu, S; Gao, Y; Shen, Y; Fan, M; Wang, S
Hedgehog (Hh) signaling plays many key roles in the development of Drosophila and vertebrate embryos including regulation of craniofacial development. The seven-transmembrane protein, smoothened (Smo) transduces the Hh signal across the plasma membrane as an essential receptor of PTCHED1/2. There are few studies that evaluate the detailed expression of Smo in mouse embryonic craniofacial development. We investigated the expression patterns of Smo during murine embryonic craniofacial development using in situ hybridization (ISH), studies of whole-mounts and sections, immunohistochemistry, quantitative real time PCR, and Western blot analysis. We found that Smo mRNA was expressed in the face of mouse embryos at 11 and 12.5 days post coitum (dpc). After 13.5 dpc, the expression decreased to a low level and was faintly detected after birth. Smo protein could be detected also in embryos at 11, 12.5, and 14.5 dpc. After 15.5 dpc, the expression was very faint and paralleled the gene expression studies. No expression was detected in whisker follicle during facial development and faint signal was detected in Meckel's cartilage. These findings concerning Smo expression should guide further investigation of sonic Hh signaling pathway gene function during maxillofacial development.
Full Text Available To cope with the severe masking of background cerebral activity in the electroencephalogram (EEG by ocular movement artefacts, we present a method which combines lower-order, short-term and higher-order, long-term statistics. The joint smoothened subspace estimator (JSSE calculates the joint information in both statistical models, subject to the constraint that the resulting estimated source should be sufficiently smooth in the time domain (i.e., has a large autocorrelation or self predictive power. It is shown that the JSSE is able to estimate a component from simulated data that is superior with respect to methodological artefact suppression to those of FastICA, SOBI, pSVD, or JADE/COM1 algorithms used for blind source separation (BSS. Interference and distortion suppression are of comparable order when compared with the above-mentioned methods. Results on patient data demonstrate that the method is able to suppress blinking and saccade artefacts in a fully automated way.
Bee, Weilin Tiger; Xie, Wensheng; Truong, Maggie; Will, Matthew; Turunen, Brandon; Zuercher, William J; McMillan, Lynette; Li, Hu; Hornberger, Keith R; Davenport, Elizabeth A; Ames, Robert S; Kallal, Lorena A
In this study, the development of an image-based high-content screening (HCS) binding assay for the seven-transmembrane (7TM) receptor Smoothened (Smo) is described. Using BacMam-based gene delivery of Smo, BODIPY-cyclopamine as a fluorescent probe, and a confocal imaging system, a robust 384-well assay that could be used for high-throughput compound profiling activities was developed. The statistically robust HCS binding assay was developed through optimization of multiple parameters, including cell transduction conditions, Smo expression levels, the image analysis algorithm, and staining procedures. Evaluation of structurally diverse compounds, including functional Smo activators, inhibitors, and related analogs, demonstrated good compound potency correlations between high-content imaging binding, membrane fluorescence polarization binding, and gene reporter assays. Statistical analysis of data from a screening test set of compounds at a single 10-µM concentration suggested that the high-content imaging Smo binding assay is amenable for use in hit identification. The 384-well HCS assay was rapidly developed and met statistical assay performance targets, thus demonstrating its utility as a fluorescent whole-cell binding assay suitable for compound screening and profiling.
Full Text Available Abstract Background Recreational facilities are an important community resource for health promotion because they provide access to affordable physical activities. However, despite their health mandate, many have unhealthy food environments that may paradoxically increase the risk of childhood obesity. The Alberta Nutrition Guidelines for Children and Youth (ANGCY are government-initiated, voluntary guidelines intended to facilitate children’s access to healthy food and beverage choices in schools, childcare and recreational facilities, however few recreational facilities are using them. Methods We used mixed methods within an exploratory multiple case study to examine factors that influenced adoption and implementation of the ANGCY and the nature of the food environment within three cases: an adopter, a semi-adopter and a non-adopter of the ANGCY. Diffusion of Innovations theory provided the theoretical platform for the study. Qualitative data were generated through interviews, observations, and document reviews, and were analysed using directed content analysis. Set theoretic logic was used to identify factors that differentiated adopters from the non-adopter. Quantitative sales data were also collected, and the quality of the food environment was scored using four complementary tools. Results The keys to adoption and implementation of nutrition guidelines in recreational facilities related to the managers’ nutrition-related knowledge, beliefs and perceptions, as these shaped his decisions and actions. The manager, however, could not accomplish adoption and implementation alone. Intersectoral linkages with schools and formal, health promoting partnerships with industry were also important for adoption and implementation to occur. The food environment in facilities that had adopted the ANGCY did not appear to be superior to the food environment in facilities that had not adopted the ANGCY. Conclusions ANGCY uptake may continue to falter
Lin, Tara L; Matsui, William
Emerging laboratory and clinical investigations demonstrate that Hedgehog signaling (Hh) represents a novel therapeutic target in various human cancers. This conserved signaling pathway precisely regulates self-renewal and terminal differentiation in embryonic development, but is typically silenced in adult tissues, with reactivation usually only during tissue repair. Aberrant Hh pathway signaling has been implicated in the pathogenesis, self-renewal, and chemotherapy resistance of a growing number of solid and hematologic malignancies. Major components of the Hh pathway include the Hh ligands (Sonic, Desert, and Indian), the transmembrane receptor Patched, the signal transducer Smoothened (Smo), and transcription factors Gli1-3 which regulate the transcription of Hh target genes. Mutations in Hh pathway genes, increased Hh signaling in tumor stroma, and Hh overexpression in self-renewing cells (cancer stem cells) have been described, and these different modes of Hh signaling have implications for the design of Hh pathway inhibitors and their integration into conventional treatment regimens. Discovery of a naturally-occurring Smo inhibitor, cyclopamine, and the identification of Hh pathway mutations and over expression in cancer cells prompted the development of several cyclopamine derivatives. Encouraging laboratory and in vivo data has resulted in Phase I and II clinical trials of Smo inhibitors. In this review, we will discuss the current understanding of Hh pathway signaling in malignancy and Smo antagonists in development. Recent data with these agents shows that they are well-tolerated and may be effective for subsets of patients. Challenges remain for appropriate patient selection and the optimal combination and sequence of these targeted therapies into current treatment paradigms.
Janet J Y Choi
Full Text Available Various studies suggest that Hedgehog (Hh signalling plays roles in human and zebrafish ocular development. Recent studies (Kerr et al., Invest Ophthalmol Vis Sci. 2012; 53, 3316-30 showed that conditionally activating Hh signals promotes murine lens epithelial cell proliferation and disrupts fibre differentiation. In this study we examined the expression of the Hh pathway and the requirement for the Smoothened gene in murine lens development. Expression of Hh pathway components in developing lens was examined by RT-PCR, immunofluorescence and in situ hybridisation. The requirement of Smo in lens development was determined by conditional loss-of-function mutations, using LeCre and MLR10 Cre transgenic mice. The phenotype of mutant mice was examined by immunofluorescence for various markers of cell cycle, lens and cornea differentiation. Hh pathway components (Ptch1, Smo, Gli2, Gli3 were detected in lens epithelium from E12.5. Gli2 was particularly localised to mitotic nuclei and, at E13.5, Gli3 exhibited a shift from cytosol to nucleus, suggesting distinct roles for these transcription factors. Conditional deletion of Smo, from ∼E12.5 (MLR10 Cre did not affect ocular development, whereas deletion from ∼E9.5 (LeCre resulted in lens and corneal defects from E14.5. Mutant lenses were smaller and showed normal expression of p57Kip2, c-Maf, E-cadherin and Pax6, reduced expression of FoxE3 and Ptch1 and decreased nuclear Hes1. There was normal G1-S phase but decreased G2-M phase transition at E16.5 and epithelial cell death from E14.5-E16.5. Mutant corneas were thicker due to aberrant migration of Nrp2+ cells from the extraocular mesenchyme, resulting in delayed corneal endothelial but normal epithelial differentiation. These results indicate the Hh pathway is required during a discrete period (E9.5-E12.5 in lens development to regulate lens epithelial cell proliferation, survival and FoxE3 expression. Defective corneal development occurs
Choi, Janet J Y; Ting, Chao-Tung; Trogrlic, Lidia; Milevski, Stefan V; Familari, Mary; Martinez, Gemma; de Iongh, Robb U
Various studies suggest that Hedgehog (Hh) signalling plays roles in human and zebrafish ocular development. Recent studies (Kerr et al., Invest Ophthalmol Vis Sci. 2012; 53, 3316-30) showed that conditionally activating Hh signals promotes murine lens epithelial cell proliferation and disrupts fibre differentiation. In this study we examined the expression of the Hh pathway and the requirement for the Smoothened gene in murine lens development. Expression of Hh pathway components in developing lens was examined by RT-PCR, immunofluorescence and in situ hybridisation. The requirement of Smo in lens development was determined by conditional loss-of-function mutations, using LeCre and MLR10 Cre transgenic mice. The phenotype of mutant mice was examined by immunofluorescence for various markers of cell cycle, lens and cornea differentiation. Hh pathway components (Ptch1, Smo, Gli2, Gli3) were detected in lens epithelium from E12.5. Gli2 was particularly localised to mitotic nuclei and, at E13.5, Gli3 exhibited a shift from cytosol to nucleus, suggesting distinct roles for these transcription factors. Conditional deletion of Smo, from ∼E12.5 (MLR10 Cre) did not affect ocular development, whereas deletion from ∼E9.5 (LeCre) resulted in lens and corneal defects from E14.5. Mutant lenses were smaller and showed normal expression of p57Kip2, c-Maf, E-cadherin and Pax6, reduced expression of FoxE3 and Ptch1 and decreased nuclear Hes1. There was normal G1-S phase but decreased G2-M phase transition at E16.5 and epithelial cell death from E14.5-E16.5. Mutant corneas were thicker due to aberrant migration of Nrp2+ cells from the extraocular mesenchyme, resulting in delayed corneal endothelial but normal epithelial differentiation. These results indicate the Hh pathway is required during a discrete period (E9.5-E12.5) in lens development to regulate lens epithelial cell proliferation, survival and FoxE3 expression. Defective corneal development occurs secondary to defects
Walker, Kathrin C.
The roles that program leaders establish in their relationships with youth structure how leaders are able to foster youth development. This article examines the complex roles program leaders create in youth programs and investigates how they balanced multiple roles to most effectively respond to the youth they serve. Analyses of qualitative data…
Jagmohan Singh; Vipin Bharti
Gingival recession related to periodontal disease or developmental problems can result in root sensitivity, root caries, and esthetically unacceptable root exposures. In the past, multiple surgical procedures have been proposed to obtain root coverage on exposed buccal root surfaces. There has been great interest in the treatment of gingival recession defects, especially with subepithelial connective-tissue grafting (SCTG). Recent advances have focused on SCTG by the tunnel technique. This ar...
Skvara, Hans; Kalthoff, Frank; Meingassner, Josef G.; Wolff-Winiski, Barbara; Aschauer, Heinrich; Kelleher, Joseph F.; Wu, Xu; Pan, Shifeng; Mickel, Lesanka; Schuster, Christopher; Stary, Georg; Jalili, Ahmad; David, Olivier J.; Emotte, Corinne; Antunes, Ana Monica Costa; Rose, Kristine; Decker, Jeremy; Carlson, Ilene; Gardner, Humphrey; Stuetz, Anton; Bertolino, Arthur P.; Stingl, Georg; de Rie, Menno A.
Basal cell carcinoma (BCC) is a distinctive manifestation in nevoid basal cell carcinoma syndrome (NBCCS) patients. Both inherited and acquired mutations of patched 1 (PTCH1), a tumor-suppressor gene controlling the activity of Smoothened (SMO), are the primary cause of the constitutive activation
Ochi, Haruki; Pearson, Bret J; Chuang, Pao-Tien; Hammerschmidt, Matthias; Westerfield, Monte
Sharp borders between cells with different developmental fates are important for patterning of invertebrates, but are not well understood in vertebrates. Zebrafish slow muscle cells develop from adaxial cells, a one-cell-diameter-thick pseudo-epithelium immediately adjacent to the notochord. Hedgehog (Hh) signals from notochord specify adaxial cells to form slow muscle cells. Cells next to adaxial cells form fast muscle. This suggests that Hh signaling is locally regulated to produce a sharp border that separates slow and fast muscle precursors. To understand how Hh activity is locally regulated, we characterized the dynamic roles of Hhip, a protein that binds Hedgehog at the cell surface. Hhip is strongly expressed by adaxial cells and, together with Patched, the Hedgehog receptor, limits transduction of the Hedgehog signaling by Smoothened to adaxial cells. Hhip protein lacking its membrane associated domain still suppresses Hh activity but no longer acts synergistically with Patched. Hhip and Smoothened colocalize at the cell surface and, in response to Hedgehog, internalize together. Knockdown of Hhip blocks Smoothened internalization while increasing Hedgehog signaling and slow muscle formation. These data support a model in which Hhip regulates muscle development both by sequestering Hedgehog and by modulating localization of Smoothened.
Éder Danilo Bezerra
Full Text Available The present paper has as its main goal to analyze, through a multiple case study, the impact caused by the adoption of new technologies in tourism businesses, which increasingly incorporate technology to their activities. For this, we conducted semi-structured interviews with managers of four bars and restaurants of Aracaju’s seafront (Sergipe/Brazil, supported by a survey that assessed how the adoption of electronic controls by these companies affects both their customers' perceptions regarding the quality of their services, as well as their employees' perception about the technology as a working tool. In this sense, this research is based on the theory of diffusion of innovations proposed by Rogers (1995, which points out five attributes perceived in innovation that influence the individual decision to either adopt or reject an innovation. As the results and implications of the study we can highlight the attempt of bridging dichotomous concepts in innovation, emphasizing the role of technology in the service sector, and providing a reflection on the convergence between the human and technological aspects that transform concepts and ideas deeply rooted in innovation studies and tourism, and also the discussion about the extent to which there is a need for such sector to increase the presence of technology in their activities, given the different perceptions of the involved parts about the role of the technological innovation in tourism.
Shyamala, Baragur V; Bhat, Krishna Moorthi
The transmembrane receptor Patched regulates several developmental processes in both invertebrates and vertebrates. In vertebrates, Patched also acts as a tumor suppressor. The Patched pathway normally operates by negatively regulating Smoothened, a G-protein-coupled receptor; binding of Hedgehog ligand to Patched relieves this negative interaction and allows signaling by Smoothened. We show that Ptc regulates Drosophila head development by promoting cell proliferation in the eye-antennal disc. During head morphogenesis, Patched positively interacts with Smoothened, which leads to the activation of Activin type I receptor Baboon and stimulation of cell proliferation in the eye-antennal disc. Thus, loss of Ptc or Smoothened activity affects cell proliferation in the eye-antennal disc and results in adult head capsule defects. Similarly, reducing the dose of smoothened in a patched background enhances the head defects. Consistent with these results, gain-of-function Hedgehog interferes with the activation of Baboon by Patched and Smoothened, leading to a similar head capsule defect. Expression of an activated form of Baboon in the patched domain in a patched mutant background completely rescues the head defects. These results provide insight into head morphogenesis, a process we know very little about, and reveal an unexpected non-canonical positive signaling pathway in which Patched and Smoothened function to promote cell proliferation as opposed to repressing it.
Tang, Mianzhi; Luo, Sarah X; Tang, Vivian; Huang, Eric J
Several studies have indicated that Sonic hedgehog (Shh) regulates the expansion of dopaminergic (DA) progenitors and the subsequent generation of mature DA neurons. This prevailing view has been based primarily on in vitro culture results, and the exact in vivo function of Shh signaling in the patterning and neurogenesis of the ventral midbrain (vMB) remains unclear. We characterized the transcriptional codes for the vMB progenitor domains, and correlated them with the expression patterns of Shh signaling effectors, including Shh, Smoothened, Patched, Gli1, Gli2 and Gli3. While Shh and its downstream effectors showed robust expression in the neurogenic niche for DA progenitors at embryonic day (E)8 to E8.5, their expression shifted to the lateral domains from E9.5 to E12.5. Consistent with this dynamic change, conditional mutants with region-specific removal of the Shh receptor Smoothened in the vMB progenitors (Shh-Cre;Smo(fl/fl)) showed a transient reduction in DA progenitors and DA neurons at E10.5, but had more profound defects in neurons derived from the more lateral domains, including those in the red nucleus, oculomotor nucleus, and raphe nuclei. Conversely, constitutive activation of Smoothened signaling in vMB (Shh-Cre;SmoM2) showed transient expansion of the same progenitor population. To further characterize the nature of Shh-Smoothened signaling in vMB, we examined the BAT-GAL reporter and the expression of Wnt1 in vMB, and found that the antagonistic effects of Shh and Wnt signaling critically regulate the development of DA progenitors and DA neurons. These results highlight previously unrecognized effects of Shh-Smoothened signaling in the region-specific neurogenesis within the vMB.
Purvins, Arturs; Papaioannou, Ioulia T.; Debarberis, Luigi
Highlights: ► Battery system application in demand smoothening in distribution grids is analysed. ► Five European countries are studied with and without high photovoltaic deployment. ► A sensitivity analysis for different battery system parameters is performed. ► A simple battery system management is sufficient for low demand smoothening. ► More elaborate management is required for high demand smoothening. - Abstract: This article analyses in technical terms the application of battery-based storage systems for household-demand smoothening in electricity-distribution grids. The analysis includes case studies of Denmark, Portugal, Greece, France and Italy. A high penetration of photovoltaic systems in distribution grids is considered as an additional scenario. A sensitivity analysis is performed in order to examine the smoothening effect of daily demand profiles for different configurations of the battery system. In general, battery-storage systems with low rated power and low battery capacity can smooth the demand sufficiently with the aid of a simple management process. For example, with 1 kW of peak demand, a 30–45% decrease in the variability of the daily demand profile can be achieved with a battery system of 0.1 kW rated power and up to 0.6 kW h battery capacity. However, further smoothening requires higher battery-system capacity and power. In this case, more elaborate management is also needed to use the battery system efficiently.
Wu, Chuanqing; Hu, Shaobo; Cheng, Ji; Wang, Guobin; Tao, Kaixiong
The sonic hedgehog (Shh) pathway has been proven to be involved in embryonic development and cancer growth. GDC-0449, an antagonist of the hedgehog signaling receptor Smoothened (Smo), was recently approved by the US Food and Drug Administration as a prescription for skin basal cell carcinoma. However, the efficacy of GDC-0449 in the treatment of colon cancer and other malignancies, such as basal cell carcinoma and pancreatic cancer, has remained to be proven. The present study assessed the e...
This study employs a multiple-case study method, identifies barriers to the adoption of low carbon production, and categorizes these barriers into four domains: structural, regulatory, cultural, and contextual. The two most frequently mentioned barriers were “lack of financial incentives to stimulate low carbon innovation” and “lack of a common definition of low carbon production”. The two least frequently mentioned barriers were “silos exist between planning and production” and “operational staff are often physically separated from planning staff, which isolates them from planning decisions”. Furthermore, contextual barriers were significantly related to structural and regulatory barriers, while regulatory barriers were significantly related to structural barriers. Larger firms tend to have a more structured organization and lower perceptions of the employment term barrier. However, larger structured organizations have been affected by a long history of a planning-oriented economy and hence tend to have inflexible hierarchical systems. In contrast, small firms have hierarchical systems with less effect on low carbon production than those of large enterprises. Another interesting trend is the direct size effect on cultural barriers, which is evident in a culture of risk aversion, as well as the lack of low carbon technology and the existence of silos between planning and production. - Highlights: • Barriers were categorized as structural, regulatory, cultural and contextual. • Contextual barriers were significantly related to structural and regulatory barriers. • Regulatory barriers were significantly related to structural barriers. • Firm size directly affected firm hierarchical systems and cultural barriers
Okubo, N.; Takeda, Y.; Amekura, H.; Zhao, J.P.; Gritsyna, V.T.; Kishimoto, N.
A dynamic mixing method has been developed to fabricate thick insulator films containing metal nanoparticles. The fabrication process consists of negative ion mixing/implantation and vacuum deposition of the matrix material. Negative Cu ions of 60 keV irradiated a silica substrate at a dose rate 5-30 μA/cm 2 and a simultaneous evaporation of silica glass, at an evaporation rate 0.2-0.4 nm/s, produced thick films up to 500 nm. The surface of the samples was greatly smoothened by the dynamic negative-ion mixing (DNIM) method, as compared to that of evaporated films without ion irradiation. The frequency of the Si-O-Si stretching vibration mode of the DNIM samples became smaller than that of the silica glass substrates. Optical absorbance of the samples, particularly around Cu plasmon resonance, was significantly dependent on the Cu dose rate. The results indicate that the ion co-irradiation induces not only surface smoothening but also a compact network of the SiO 2 matrix
Full Text Available Hung Q Doan,1 Sirunya Silapunt,1 Michael R Migden2,3 1Department of Dermatology, University of Texas, McGovern Medical School, 2Mohs Surgery Unit, Department of Dermatology, 3Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Abstract: Basal cell carcinoma (BCC is the most common nonmelanoma skin cancer. If left untreated, BCCs can become locally aggressive or even metastasize. Currently available treatments include local destruction, surgery, and radiation. Systemic options for advanced disease are limited. The Hedgehog (Hh pathway is aberrantly activated in a majority of BCCs and in other cancers. Hh pathway inhibitors are targeted agents that inhibit the aberrant activation of the Hh pathway, with smoothened being a targeted component. Sonidegib is a novel smoothened inhibitor that was recently approved by the US Food and Drug Administration. This review focuses on BCC pathogenesis and the clinical efficacy of sonidegib for the treatment of advanced BCC. Keywords: nonmelanoma skin cancer, Hedgehog pathway, clinical trials
Full Text Available One of the causes of permanent disability in chronic multiple sclerosis patients is the inability of oligodendrocyte progenitor cells (OPCs to terminate their maturation program at lesions. To identify key regulators of myelin gene expression acting at the last stages of OPC maturation we developed a drug repositioning strategy based on the mouse immortalized oligodendrocyte (OL cell line Oli-neu brought to the premyelination stage by stably expressing a key factor regulating the last stages of OL maturation. The Prestwick Chemical Library of 1,200 FDA-approved compound(s was repositioned at three dosages based on the induction of Myelin Basic Protein (MBP expression. Drug hits were further validated using dosage-dependent reproducibility tests and biochemical assays. The glucocorticoid class of compounds was the most highly represented and we found that they can be divided in three groups according to their efficacy on MBP up-regulation. Since target identification is crucial before bringing compounds to the clinic, we searched for common targets of the primary screen hits based on their known chemical-target interactomes, and the pathways predicted by top ranking compounds were validated using specific inhibitors. Two of the top ranking compounds, Halcinonide and Clobetasol, act as Smoothened (Smo agonists to up-regulate myelin gene expression in the Oli-neuM cell line. Further, RxRγ activation is required for MBP expression upon Halcinonide and Clobetasol treatment. These data indicate Clobetasol and Halcinonide as potential promyelinating drugs and also provide a mechanistic understanding of their mode of action in the pathway leading to myelination in OPCs. Furthermore, our classification of glucocorticoids with respect to MBP expression provides important novel insights into their effects in the CNS and a rational criteria for their choice in combinatorial therapies in de-myelinating diseases.
Oliveira, Bianca Daniela Velez
Mestrado em Marketing How Customer Relationship Management (CRM) is regarded has been changing over time, and is currently a phenomenon with considerable importance, not only for big organizations but also for Small and Medium Enterprises (SMEs), due to the competitiveness that presently exists. After the literature review about the theme, the research questions emerged were: Why do SMEs need to implement CRM? How is CRM implemented in SMEs? In this, we proposed a methodology for the adopt...
Hao, Yan-li; Hong, Le-peng; Chan, Sun-on; Dong, Wei-ren
To examine the change of Smoothened (Smo) expression in the retinofugal pathway and in the growth cones during the period of embryonic day 13 (E13) to E15. Smo expression in the chiasm and growth cones was observed by fluorescent immunostaining and retinal explant culture. On E13 and E14, Smo was expressed moderately in the retina and optic disc, and in the corner of the retina, Smo expression was especially dense. On E13, Smo expression was detected in the optic nerves and ventral diencephalon, but only in the superficial region of the optic tract on E14. Smo was also detected in the stem and filopodia of the growth cones in the retinal explant culture during this period. Smo expression changes in different developmental phases, suggesting that Smo might play a role in signal optic axon growth during the development of the retinofugal pathway.
Full Text Available Leslie A Fecher,1,3 William H Sharfman2 1Department of Internal Medicine and Dermatology, Indiana University Health Simon Cancer Center, Indianapolis, IN, USA; 2The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA, 3Department of Internal Medicine and Dermatology, University of Michigan, MI, USA Abstract: Cutaneous basal cell carcinoma (BCC is the most common human cancer and its incidence is rising worldwide. Ultraviolet radiation exposure, including tanning bed use, as well as host factors play a role in its development. The majority of cases are treated and cured with local therapies including surgery. Yet, the health care costs of diagnosis and treatment of BCCs in the US is substantial. In the United States, the cost of nonmelanoma skin cancer care in the Medicare population is estimated to be US$426 million per year. While rare, locally advanced BCCs that can no longer be controlled with surgery and/or radiation, and metastatic BCCs do occur and can be associated with significant morbidity and mortality. Vismodegib (GDC-0449, a smoothened inhibitor targeted at the hedgehog pathway, is the first US Food and Drug Association (FDA-approved agent in the treatment of locally advanced, unresectable, and metastatic BCCs. This class of agents appears to be changing the survival rates in advanced BCC patients, but appropriate patient selection and monitoring are important. Multidisciplinary assessments are essential for the optimal care and management of these patients. For some patients with locally advanced BCC, treatment with a hedgehog inhibitor may eliminate the need for an excessively disfiguring or morbid surgery. Keywords: basal cell carcinoma, hedgehog, smoothened, vismodegib, Gorlin, basal cell nevus syndrome
Grotevant, Harold D; Lo, Albert Yh
Challenges in adoptive parenting continue to emerge as adoption policies and practices evolve. We review three areas of research in adoptive parenting that reflect contemporary shifts in adoption. First, we highlight recent findings concerning openness in adoption contact arrangements, or contact between a child's families of birth and rearing. Second, we examine research regarding racial and cultural socialization in transracial and international adoptions. Finally, we review investigations of parenting experiences of lesbian and gay adoptive parents. Overall, parenting processes (e.g., supportive vs. problematic family interaction) are better predictors of child adjustment than are group differences (e.g., open vs. closed adoptions; adoption by heterosexual vs. same-sex parents). The distinctive needs of adopted children call for preparation of adoption-competent mental health, casework, education, and health care professionals. Copyright © 2017 Elsevier Ltd. All rights reserved.
Ketley, Ami; Warren, Anne; Holmes, Emily; Gering, Martin; Aboobaker, A Aziz; Brook, J David
The importance of microRNAs in development is now widely accepted. However, identifying the specific targets of individual microRNAs and understanding their biological significance remains a major challenge. We have used the zebrafish model system to evaluate the expression and function of microRNAs potentially involved in muscle development and study their interaction with predicted target genes. We altered expression of the miR-30 microRNA family and generated phenotypes that mimicked misregulation of the Hedgehog pathway. Inhibition of the miR-30 family increases activity of the pathway, resulting in elevated ptc1 expression and increased numbers of superficial slow-muscle fibres. We show that the transmembrane receptor smoothened is a target of this microRNA family. Our results indicate that fine coordination of smoothened activity by the miR-30 family allows the correct specification and differentiation of distinct muscle cell types during zebrafish embryonic development.
Full Text Available The importance of microRNAs in development is now widely accepted. However, identifying the specific targets of individual microRNAs and understanding their biological significance remains a major challenge. We have used the zebrafish model system to evaluate the expression and function of microRNAs potentially involved in muscle development and study their interaction with predicted target genes. We altered expression of the miR-30 microRNA family and generated phenotypes that mimicked misregulation of the Hedgehog pathway. Inhibition of the miR-30 family increases activity of the pathway, resulting in elevated ptc1 expression and increased numbers of superficial slow-muscle fibres. We show that the transmembrane receptor smoothened is a target of this microRNA family. Our results indicate that fine coordination of smoothened activity by the miR-30 family allows the correct specification and differentiation of distinct muscle cell types during zebrafish embryonic development.
Wu, Chuanqing; Hu, Shaobo; Cheng, Ji; Wang, Guobin; Tao, Kaixiong
The sonic hedgehog (Shh) pathway has been proven to be involved in embryonic development and cancer growth. GDC-0449, an antagonist of the hedgehog signaling receptor Smoothened (Smo), was recently approved by the US Food and Drug Administration as a prescription for skin basal cell carcinoma. However, the efficacy of GDC-0449 in the treatment of colon cancer and other malignancies, such as basal cell carcinoma and pancreatic cancer, has remained to be proven. The present study assessed the effect of GDC-0449 on the colon cancer cell lines Caco-2 and Ht-29. A Cell Counting Kit-8 assay was applied to assess the cell proliferation rate and apoptosis was tested by flow cytometry. Reverse-transcription quantitative PCR and western blot analysis were used for analyzing expression levels of target genes. Cell proliferation was inhibited, while apoptosis was increased by GDC-0449, whereas the expression of B-cell lymphoma 2 (Bcl-2), a downstream target of Shh signaling, was decreased. Consistent with the inhibition of Gli1 expression, the cancer stem cell markers CD44 and ALDH were decreased in the presence of GDC-0449. In conclusion, GDC-0449 was shown to inhibit the replication of colon cancer cells and trigger apoptosis through downregulating Bcl-2. This may also influence the stemness of cancer stem cells as indicated by the decreased stem cell surface markers.
Desch, P; Asslaber, D; Kern, D; Schnidar, H; Mangelberger, D; Alinger, B; Stoecher, M; Hofbauer, S W; Neureiter, D; Tinhofer, I; Aberger, F; Hartmann, T N; Greil, R
The Hedgehog (Hh) pathway regulates cell proliferation and survival and contributes to tumorigenesis. We investigated the expression and function of this pathway in B-cell chronic lymphocytic leukemia (CLL) cells and in healthy B lymphocytes. Profiling of cognate Hh pathway members revealed reduced expression of two key Hh signaling effectors, Smoothened (SMOH) and GLI, in CLL cells, whereas transcription levels of other investigated members resembled normal B-lymphocyte levels. Examining the functional role of SMOH and GLI in cell survival, we found that CLL cells were hardly sensitive toward specific SMOH inhibition, but showed an unspecific decline in cell viability in response to high concentrations of the SMOH antagonist cyclopamine. In contrast, treatment with the novel GLI antagonist GANT61 reduced expression of the target gene Patched and preferentially decreased the viability of malignant cells. Specific RNA interference knockdown experiments in a CLL-derived cell line confirmed the autonomous role of GLI in malignant cell survival. GANT61-induced apoptosis in primary leukemic cells was partly attenuated by protective stromal cells, but not soluble sonic hedgehog ligand. In summary, our data show a downregulation of the classical Hh pathway in CLL and suggest an intrinsic SMOH-independent role of GLI in the ex vivo survival of CLL cells.
Ma, Haikuo; Lu, Wenfeng; Sun, Zhijian; Luo, Lusong; Geng, Delong; Yang, Zhaohui; Li, Enqin; Zheng, Jiyue; Wang, Meiyu; Zhang, Hongjian; Yang, Shilin; Zhang, Xiaohu
The Smoothened (Smo) receptor is an important component of the hedgehog (Hh) signaling pathway, which plays a critical role during embryonic development. In adults, Hh signaling is curtailed and has limited functions such as stem cell maintenance and tissue repair. However, aberrant activity of the Hh signaling in adults has been linked to numerous human cancers. Inhibition of Smo leads to the blockade of Hh signaling, and therefore represents a promising approach toward novel anticancer therapy. Through scaffold morphing of a few known Smo antagonists, a series of novel tetrahydrothiazolopyridine derivatives were developed. Compounds from this new scaffold demonstrated excellent Hh signaling inhibition which was comparable to or better than that of Vismodegib. Further, compound 30 exhibited a lower melting point and a moderately improved solubility compared with those of Vismodegib; compounds 11 and 30 showed good pharmacokinetic profiles with 34% and 77% oral bioavailability in rat, respectively. Collectively, these results strongly support further optimization of this novel scaffold to develop better Smo antagonists. Copyright © 2014 Elsevier Masson SAS. All rights reserved.
Luchetti, Giovanni; Sircar, Ria; Kong, Jennifer H; Nachtergaele, Sigrid; Sagner, Andreas; Byrne, Eamon FX; Covey, Douglas F; Siebold, Christian; Rohatgi, Rajat
Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system in development. Cholesterol influences Hh signaling by directly activating Smoothened (SMO), an orphan GPCR that transmits the Hh signal across the membrane in all animals. Unlike many GPCRs, which are regulated by cholesterol through their heptahelical transmembrane domains, SMO is activated by cholesterol through its extracellular cysteine-rich domain (CRD). Residues shown to mediate cholesterol binding to the CRD in a recent structural analysis also dictate SMO activation, both in response to cholesterol and to native Hh ligands. Our results show that cholesterol can initiate signaling from the cell surface by engaging the extracellular domain of a GPCR and suggest that SMO activity may be regulated by local changes in cholesterol abundance or accessibility. DOI: http://dx.doi.org/10.7554/eLife.20304.001 PMID:27705744
Yang, Cuiping; Chen, Wenlin; Chen, Yongbin; Jiang, Jin
Hedgehog (Hh) signaling plays pivotal roles in embryonic development and adult tissue homeostasis in species ranging from Drosophila to mammals. The Hh signal is transduced by Smoothened (Smo), a seven-transmembrane protein related to G protein coupled receptors. Despite a conserved mechanism by which Hh activates Smo in Drosophila and mammals, how mammalian Hh signal is transduced from Smo to the Gli transcription factors is poorly understood. Here, we provide evidence that two ciliary proteins, Evc and Evc2, the products of human disease genes responsible for the Ellis-van Creveld syndrome, act downstream of Smo to transduce the Hh signal. We found that loss of Evc/Evc2 does not affect Sonic Hedgehog-induced Smo phosphorylation and ciliary localization but impedes Hh pathway activation mediated by constitutively active forms of Smo. Evc/Evc2 are dispensable for the constitutive Gli activity in Sufu(-/-) cells, suggesting that Evc/Evc2 act upstream of Sufu to promote Gli activation. Furthermore, we demonstrated that Hh stimulates binding of Evc/Evc2 to Smo depending on phosphorylation of the Smo C-terminal intracellular tail and that the binding is abolished in Kif3a(-/-) cilium-deficient cells. We propose that Hh activates Smo by inducing its phosphorylation, which recruits Evc/Evc2 to activate Gli proteins by antagonizing Sufu in the primary cilia.
Dorn, Karolin V.; Hughes, Casey E.; Rohatgi, Rajat
SUMMARY Vertebrate Hedgehog (Hh) signaling is initiated at primary cilia by the ligand-triggered accumulation of Smoothened (Smo) in the ciliary membrane. The underlying biochemical mechanisms remain unknown. We find that Hh agonists promote the association between Smo and Evc2, a ciliary protein that is defective in two human ciliopathies. The formation of the Smo-Evc2 complex is under strict spatial control, being restricted to a distinct ciliary compartment, the EvC zone. Mutant Evc2 proteins that localize in cilia but are displaced from the EvC zone are dominant inhibitors of Hh signaling. Disabling Evc2 function blocks Hh signaling at a specific step between Smo and the downstream regulators protein kinase A and Suppressor of Fused, preventing activation of the Gli transcription factors. Our data suggest that the Smo-Evc2 signaling complex at the EvC zone is required for Hh signal transmission and elucidate the molecular basis of two human ciliopathies. PMID:22981989
Han, Jin-bin; Hua, Yong-qiang; Chen, Lian-yu; Liu, Lu-ming
Smoothened (SMO) is a member of sonic hedgehog homology (SHH) signaling pathway. It plays a key role as a bridge between patched-1 (PTCH-1) and Gli. Aberrant SHH expression can be detected in various malignant tissues, and the expression in pancreatic cancer stem cells is higher apparently. SHH signals are closely associated with self-duplication of cancer stem cells, formation of tumor vessels as well as matrixes. SMO antagonists such as cyclopamine, GDC-0449 and so on show potential to inhibit activity of SHH signaling, and arrest the growth as well as metastases of tumors. Recently, a few of SMO antagonists have been studied in phase I clinical trials and some are in phase II, meanwhile, phase I or II trials of SMO antagonists to treat pancreatic cancer are performed currently. As the classical SMO antagonist, cyclopamine is extracted from a medicinal plant. Perhaps researchers may be able to determine more effective SMO-targeting drugs from herbal medicines in the future.
Tadas K. Rimkus
Full Text Available The sonic hedgehog (Shh signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma, malignant gliomas, medulloblastoma, leukemias, and cancers of the breast, lung, pancreas, and prostate. Tumorigenesis, tumor progression and therapeutic response have all been shown to be impacted by the Shh signaling pathway. Downstream effectors of the Shh pathway include smoothened (SMO and glioma-associated oncogene homolog (GLI family of zinc finger transcription factors. Both are regarded as important targets for cancer therapeutics. While most efforts have been devoted towards pharmacologically targeting SMO, developing GLI-targeted approach has its merit because of the fact that GLI proteins can be activated by both Shh ligand-dependent and -independent mechanisms. To date, two SMO inhibitors (LDE225/Sonidegib and GDC-0449/Vismodegib have received FDA approval for treating basal cell carcinoma while many clinical trials are being conducted to evaluate the efficacy of this exciting class of targeted therapy in a variety of cancers. In this review, we provide an overview of the biology of the Shh pathway and then detail the current landscape of the Shh-SMO-GLI pathway inhibitors including those in preclinical studies and clinical trials.
Fecher, Leslie A; Sharfman, William H
Cutaneous basal cell carcinoma (BCC) is the most common human cancer and its incidence is rising worldwide. Ultraviolet radiation exposure, including tanning bed use, as well as host factors play a role in its development. The majority of cases are treated and cured with local therapies including surgery. Yet, the health care costs of diagnosis and treatment of BCCs in the US is substantial. In the United States, the cost of nonmelanoma skin cancer care in the Medicare population is estimated to be US$426 million per year. While rare, locally advanced BCCs that can no longer be controlled with surgery and/or radiation, and metastatic BCCs do occur and can be associated with significant morbidity and mortality. Vismodegib (GDC-0449), a smoothened inhibitor targeted at the hedgehog pathway, is the first US Food and Drug Association (FDA)-approved agent in the treatment of locally advanced, unresectable, and metastatic BCCs. This class of agents appears to be changing the survival rates in advanced BCC patients, but appropriate patient selection and monitoring are important. Multidisciplinary assessments are essential for the optimal care and management of these patients. For some patients with locally advanced BCC, treatment with a hedgehog inhibitor may eliminate the need for an excessively disfiguring or morbid surgery. PMID:26604681
Full Text Available Abstract Background There is considerable scope to improve the delivery of practices that increase the physical activity of children in centre based childcare services. Few studies have reported the effectiveness of interventions to address this, particularly at a population level. The primary aim of this study was to describe the impact of an intervention to increase the adoption of multiple policies and practices to promote physical activity in centre based childcare services. Methods A quasi experimental study was conducted in centre based childcare services (n =228 in New South Wales (NSW, Australia and involved a three month intervention to increase the adoption of eight practices within childcare services that have been suggested to promote child physical activity. Intervention strategies to support the adoption of practices included staff training, resources, incentives, follow-up support and performance monitoring and feedback. Randomly selected childcare services in the remainder of NSW acted as a comparison group (n = 164 and did not receive the intervention but may have been exposed to a concurrent NSW government healthy eating and physical activity initiative. Self reported information on physical activity policies, fundamental movement skills sessions, structured physical activity opportunities, staff involvement in active play and provision of verbal prompts to encourage physical activity, small screen recreation opportunities, sedentary time, and staff trained in physical activity were collected by telephone survey with childcare service managers at baseline and 18 months later. Results Compared with the comparison area, the study found significantly greater increases in the prevalence of intervention services with a written physical activity policy, with policy referring to placing limits on small screen recreation, and with staff trained in physical activity. In addition, non-significant trends towards a greater increase in the
Campbell, Veronica T; Nadesan, Puviindran; Ali, S Amanda; Wang, Chang Ye Yale; Whetstone, Heather; Poon, Raymond; Wei, Qingxia; Keilty, John; Proctor, Jennifer; Wang, Lauren W; Apte, Suneel S; McGovern, Karen; Alman, Benjamin A; Wunder, Jay S
Hedgehog (Hh) pathway inhibition in cancer has been evaluated in both the ligand-independent and ligand-dependent settings, where Hh signaling occurs either directly within the cancer cells or within the nonmalignant cells of the tumor microenvironment. Chondrosarcoma is a malignant tumor of cartilage in which there is ligand-dependent activation of Hh signaling. IPI-926 is a potent, orally delivered small molecule that inhibits Hh pathway signaling by binding to Smoothened (SMO). Here, the impact of Hh pathway inhibition on primary chondrosarcoma xenografts was assessed. Mice bearing primary human chondrosarcoma xenografts were treated with IPI-926. The expression levels of known Hh pathway genes, in both the tumor and stroma, and endpoint tumor volumes were measured. Gene expression profiling of tumors from IPI-926-treated mice was conducted to identify potential novel Hh target genes. Hh target genes were studied to determine their contribution to the chondrosarcoma neoplastic phenotype. IPI-926 administration results in downmodulation of the Hh pathway in primary chondrosarcoma xenografts, as demonstrated by evaluation of the Hh target genes GLI1 and PTCH1, as well as inhibition of tumor growth. Chondrosarcomas exhibited autocrine and paracrine Hh signaling, and both were affected by IPI-926. Decreased tumor growth is accompanied by histopathologic changes, including calcification and loss of tumor cells. Gene profiling studies identified genes differentially expressed in chondrosarcomas following IPI-926 treatment, one of which, ADAMTSL1, regulates chondrosarcoma cell proliferation. These studies provide further insight into the role of the Hh pathway in chondrosarcoma and provide a scientific rationale for targeting the Hh pathway in chondrosarcoma.
Brown, Alexander S; Epstein, Douglas J
In mouse embryos lacking sonic hedgehog (Shh), dorsoventral polarity within the otic vesicle is disrupted. Consequently, ventral otic derivatives, including the cochlear duct and saccule, fail to form, and dorsal otic derivatives, including the semicircular canals, endolymphatic duct and utricle, are malformed or absent. Since inner ear patterning and morphogenesis are heavily dependent on extracellular signals derived from tissues that are also compromised by the loss of Shh, the extent to which Shh signaling acts directly on the inner ear for its development is unclear. To address this question, we generated embryos in which smoothened (Smo), an essential transducer of Hedgehog (Hh) signaling, was conditionally inactivated in the otic epithelium (Smo(ecko)). Ventral otic derivatives failed to form in Smo(ecko) embryos, whereas vestibular structures developed properly. Consistent with these findings, we demonstrate that ventral, but not dorsal, otic identity is directly dependent on Hh. The role of Hh in cochlear-vestibular ganglion (cvg) formation is more complex, as both direct and indirect signaling mechanisms are implicated. Our data suggest that the loss of cvg neurons in Shh(-/-) animals is due, in part, to an increase in Wnt responsiveness in the otic vesicle, resulting in the ectopic expression of Tbx1 in the neurogenic domain and subsequent repression of Ngn1 transcription. A mitogenic role for Shh in cvg progenitor proliferation was also revealed in our analysis of Smo(ecko) embryos. Taken together, these data contribute to a better understanding of the intrinsic and extrinsic signaling properties of Shh during inner ear development.
Martin, Jérôme; Sriramkumar, L.; Hazra, Dhiraj Kumar
Sharp shapes in the inflaton potentials often lead to short departures from slow roll which, in turn, result in deviations from scale invariance in the scalar power spectrum. Typically, in such situations, the scalar power spectrum exhibits a burst of features associated with modes that leave the Hubble radius either immediately before or during the epoch of fast roll. Moreover, one also finds that the power spectrum turns scale invariant at smaller scales corresponding to modes that leave the Hubble radius at later stages, when slow roll has been restored. In other words, the imprints of brief departures from slow roll, arising out of sharp shapes in the inflaton potential, are usually of a finite width in the scalar power spectrum. Intuitively, one may imagine that the scalar bi-spectrum too may exhibit a similar behavior, i.e. a restoration of scale invariance at small scales, when slow roll has been reestablished. However, in the case of the Starobinsky model (viz. the model described by a linear inflaton potential with a sudden change in its slope) involving the canonical scalar field, it has been found that, a rather sharp, though short, departure from slow roll can leave a lasting and significant imprint on the bi-spectrum. The bi-spectrum in this case is found to grow linearly with the wavenumber at small scales, a behavior which is clearly unphysical. In this work, we study the effects of smoothening the discontinuity in the Starobinsky model on the scalar bi-spectrum. Focusing on the equilateral limit, we analytically show that, for smoother potentials, the bi-spectrum indeed turns scale invariant at suitably large wavenumbers. We also confirm the analytical results numerically using our newly developed code BINGO. We conclude with a few comments on certain related points
Carnochan, Sarah; Moore, Megan; Austin, Michael J
While family reunification is the primary permanency objective for children who must be placed temporarily outside of their homes, reunification is not possible for all children. For those children who do not return to their parents and cannot find permanent homes with other family members, adoption is the favored outcome. This review examines the composite measure in the federal Child and Family Services Review that measures agency performance related to the timeliness of adoptions of foster children. It summarizes the multiple factors that research has found to be associated with increased risk for adoption delay and disruption. These include child characteristics, family of origin and adoptive family characteristics, and features of child welfare services and systems. Practices that have been broadly linked to adoption timeliness or address risk factors associated with delays in adoption are described, including social worker activities and agency or system-wide practice.
Lam, Winsome; Fowler, Cathrine; Dawson, Angela
In Hong Kong, the population is at risk of seasonal influenza infection twice a year. Seasonal influenza is significantly associated with the increased hospitalization of children. Maintaining personal hygiene and vaccination are the most effective measures to prevent influenza infection. Research demonstrates a positive relationship between the health practices applied by parents and the behaviour of their children highlighting the importance of parental heath education. However, there is minimal research that provides an understanding of how Hong Kong Chinese parents teach their children to prevent seasonal influenza. Mixed methods research was undertaken that employed a multiple-case study approach to gain an understanding of parental teaching practices regarding seasonal influenza prevention. Purposive intensity sampling was adopted to recruit twenty parents and their healthy children. A thematic analysis was employed to examine the qualitative interview data and the quantitative survey data were examined descriptively. These data were then integrated to provide a more rigorous understanding of parental teaching strategies. Comparisons were made across cases to reveal commonalities and differences. Five major themes were identified: processes parents used to teach personal hygiene; parent-child interaction during teaching; approaches to managing children's health behaviours; enhancing children's healthy practices; and parents' perspective of the role of the nurse in health promotion. This study provided valuable insight into the approach of Hong Kong Chinese parents in teaching their children to prevent seasonal influenza. The results indicate that parents can be better supported to develop effective strategies to teach their preschool children hygiene practices for seasonal influenza prevention. Partnerships with community nurses can play a role in building effective parent-child interactions to enhance children's learning and adoption of healthy practices.
Farias, Déborah de Araújo; Willardson, Jeffrey M; Paz, Gabriel A; Bezerra, Ewertton de S; Miranda, Humberto
Farias, DdA, Willardson, JM, Paz, GA, Bezerra, EdS, and Miranda, H. Maximal strength performance and muscle activation for the bench press and triceps extension exercises adopting dumbbell, barbell and machine modalities over multiple sets. J Strength Cond Res 31(7): 1879-1887, 2017-The purpose of this study was to investigate muscle activation, total repetitions, and training volume for 3 bench press (BP) exercise modes (Smith machine [SMBP], barbell [BBP], and dumbbell [DBP]) that were followed by a triceps extension (TE) exercise. Nineteen trained men performed 3 testing protocols in random order, which included: (P1) SMBP + TE; (P2) BBP + TE; and (P3) DBP + TE. Each protocol involved 4 sets with a 10-repetition maximum (RM) load, immediately followed by a TE exercise that was also performed for 4 sets with a 10RM load. A 2-minute rest interval was adopted between sets and exercises. Surface electromyographic activity was assessed for the pectoralis major (PM), anterior deltoid (AD), biceps brachii (BB), and triceps brachii (TB). The results indicated that significantly higher total repetitions were achieved for the DBP (31.2 ± 3.2) vs. the BBP (27.8 ± 4.8). For the TE, significantly greater volume was achieved when this exercise was performed after the BBP (1,204.4 ± 249.4 kg) and DBP (1,216.8 ± 287.5 kg) vs. the SMBP (1,097.5 ± 193 kg). The DBP elicited significantly greater PM activity vs. the BBP. The SMBP elicited significantly greater AD activity vs. the BBP and DBP. During the different BP modes, the SMBP and BBP elicited significantly greater TB activity vs. the DBP. However, the DBP elicited significantly greater BB activity vs. the SMBP and BBP, respectively. During the succeeding TE exercise, significantly greater activity of the TB was observed when this exercise was performed after the BBP vs. the SMBP and DBP. Therefore, it seems that the variation in BP modes does influence both repetition performance and muscle activation patterns during the
Paz, Gabriel Andrade; DeFreitas, Jason; de Freitas Maia, Marianna; Silva, Jurandir; Lima, Vicente; Miranda, Humberto
Crossover design. Excessive valgus and varus force which affected the knee joint during dynamic tasks has been often associated to lower extremity injuries. Strategies to increase the resistance against these asymmetries (eg, the use of a physioball between the knees or elastic bands around the knees) are often applied in rehabilitation and conditioning programs. The purpose of this study was to investigate the effect of performing leg press (LP) 45° using a physioball and elastic band over multiple sets with submaximal loads on electromyographic (EMG) amplitude and fatigue indices. 18 trained females volunteered (age: 24.4 ± 2.1 y; height: 168.1 ± 4 cm; body mass: 65.1 ± 4.4 kg) participated in this study. The 10 repetition maximum (RM) loads were determined for the LP. Then, 3 experimental protocols were followed in a randomized crossover design over 3 nonconsecutive days: control protocol-the participants performed 4 LP sets; physioball between knees-4 LP sets were performed with the physioball between the knees; elastic band-4 LP sets were performed with the elastic band involving the knees. Ten repetitions were performed during each set with 70% of 10-RM loads; EMG spectral indices (CRMS and Cf5) was collected from the biceps femoris (BF), vastus lateralis (VL), vastus medialis obliquus (VMO), and rectus femoris (RF) muscles. Higher levels of CRMS and Cf5 were noted for RF, VL, and VM muscles using the physioball and elastic band when compared with control protocol, respectively. CRMS index of BF muscle was significantly higher using physioball and elastic band protocol versus control condition, respectively. Therefore, both physioball and elastic band can be adopted during LP with the goal to reduce excessive varus and valgus forces, respectively, even performing consecutive sets with submaximal loads. Furthermore, this may be an interesting alternative to increasing quadriceps activation and improving the knee joint stabilization.
Zhang, Xianjun; Zhao, Fei; Wu, Yiran; Yang, Jun; Han, Gye Won; Zhao, Suwen; Ishchenko, Andrii; Ye, Lintao; Lin, Xi; Ding, Kang; Dharmarajan, Venkatasubramanian; Griffin, Patrick R.; Gati, Cornelius; Nelson, Garrett; Hunter, Mark S.; Hanson, Michael A.; Cherezov, Vadim; Stevens, Raymond C.; Tan, Wenfu; Tao, Houchao; Xu, Fei
The Smoothened receptor (SMO) belongs to the Class Frizzled of the G protein-coupled receptor (GPCR) superfamily, constituting a key component of the Hedgehog signalling pathway. Here we report the crystal structure of the multi-domain human SMO, bound and stabilized by a designed tool ligand TC114, using an X-ray free-electron laser source at 2.9 Å. The structure reveals a precise arrangement of three distinct domains: a seven-transmembrane helices domain (TMD), a hinge domain (HD) and an intact extracellular cysteine-rich domain (CRD). This architecture enables allosteric interactions between the domains that are important for ligand recognition and receptor activation. By combining the structural data, molecular dynamics simulation, and hydrogen-deuterium-exchange analysis, we demonstrate that transmembrane helix VI, extracellular loop 3 and the HD play a central role in transmitting the signal employing a unique GPCR activation mechanism, distinct from other multi-domain GPCRs.
Li, Chun-Lin; Toda, Katsumi; Saibara, Toshiji; Zhang, Ting; Ono, Masafumi; Iwasaki, Shinji; Maeda, Takashi; Okada, Teruhiko; Hayashi, Yoshihiro; Enzan, Hideaki; Shizuta, Yutaka; Onishi, Saburo
Aromatase is an essential enzyme for estrogen synthesis. We investigated the role of estrogen in thymocyte development using aromatase-deficient (ArKO) mice. Like its role as a regulator of bone metabolism through regulating osteoprotegerin (OPG) production, estrogen is involved in the processes of thymocyte development although aromatase mRNA was not detectable in the thymus. Thymic regression and reduced cellularity were evident in ArKO mice. The major difficulties in thymocyte development of ArKO mice were observed during the CD44+ CD25- stage at the cortico-medullary junction and during the CD44- CD25- stage at the subcapsular region where the estrogen receptor was expressed in the stromal cells. The proportion of thymocytes during the CD44+ CD25- stage was reduced. The progression of CD44- CD25+ cells to the CD44- CD25- stage was accelerated in ArKO mice possibly due to insufficient osteoprotegerin production in estrogen-deficiency. However, the expression of Smoothened of the Hedgehog signaling was enhanced in CD4- CD8- double negative cells. This enhancement may result in impaired progression of CD44- CD25- cells to the CD4+ CD8+ double positive stage and impaired proliferation of CD4+ CD8+ double positive cells since Smoothened (Smo) is known to arrest cells as non-proliferating cells. This could be the reason why the proportion of CD3+ TCRbeta(high) cells during the late phase of thymocyte maturation was reduced in ArKO mice. From these observations, we propose that estrogen supports thymocyte development and maturation at many stages through many regulatory pathways including the sonic hedgehog- and the osteoprotegerin ligand (OPGL)-mediated signaling.
Peng, Zhihui; Wong, John W; Hansen, Eric C; Puchlopek-Dermenci, Angela L A; Clarke, Hugh J
A concise, asymmetric synthesis of a smoothened receptor inhibitor (1) is described. The synthesis features an enzymatic transamination with concurrent dynamic kinetic resolution (DKR) of a 4-piperidone (4) to establish the two stereogenic centers required in a single step. This efficient reaction affords the desired anti amine (3) in >10:1 dr and >99% ee. The title compound is prepared in only five steps with 40% overall yield.
Virginia, 388 U.S. 1 (1967)(criminal statute prohibiting interracial marriages held unconstitutional violation of the Equal Protection and Due Process...such sentences does not violate the Constitution."°2 7 In effect , the double jeopardy protection from multiple punishments is coextensive with...unaware of what it accomplished . . . . In effect , the Blockburger test establishes a presumption of legislative intent: if each of two statutes
Full Text Available Hedgehog (Hh signaling controls embryonic development and adult tissue homeostasis through the G protein coupled receptor (GPCR-family protein Smoothened (Smo. Upon stimulation, Smo accumulates on the cell surface in Drosophila or primary cilia in vertebrates, which is thought to be essential for its activation and function, but the underlying mechanisms remain poorly understood. Here we show that Hh stimulates the binding of Smo to a plasma membrane-associated kinase Gilgamesh (Gish/CK1γ and that Gish fine-tunes Hh pathway activity by phosphorylating a Ser/Thr cluster (CL-II in the juxtamembrane region of Smo carboxyl-terminal intracellular tail (C-tail. We find that CL-II phosphorylation is promoted by protein kinase A (PKA-mediated phosphorylation of Smo C-tail and depends on cell surface localization of both Gish and Smo. Consistent with CL-II being critical for high-threshold Hh target gene expression, its phosphorylation appears to require higher levels of Hh or longer exposure to the same level of Hh than PKA-site phosphorylation on Smo. Furthermore, we find that vertebrate CK1γ is localized at the primary cilium to promote Smo phosphorylation and Sonic hedgehog (Shh pathway activation. Our study reveals a conserved mechanism whereby Hh induces a change in Smo subcellular localization to promote its association with and activation by a plasma membrane localized kinase, and provides new insight into how Hh morphogen progressively activates Smo.
Li, Shuangxi; Li, Shuang; Han, Yuhong; Tong, Chao; Wang, Bing; Chen, Yongbin; Jiang, Jin
Hedgehog (Hh) signaling controls embryonic development and adult tissue homeostasis through the G protein coupled receptor (GPCR)-family protein Smoothened (Smo). Upon stimulation, Smo accumulates on the cell surface in Drosophila or primary cilia in vertebrates, which is thought to be essential for its activation and function, but the underlying mechanisms remain poorly understood. Here we show that Hh stimulates the binding of Smo to a plasma membrane-associated kinase Gilgamesh (Gish)/CK1γ and that Gish fine-tunes Hh pathway activity by phosphorylating a Ser/Thr cluster (CL-II) in the juxtamembrane region of Smo carboxyl-terminal intracellular tail (C-tail). We find that CL-II phosphorylation is promoted by protein kinase A (PKA)-mediated phosphorylation of Smo C-tail and depends on cell surface localization of both Gish and Smo. Consistent with CL-II being critical for high-threshold Hh target gene expression, its phosphorylation appears to require higher levels of Hh or longer exposure to the same level of Hh than PKA-site phosphorylation on Smo. Furthermore, we find that vertebrate CK1γ is localized at the primary cilium to promote Smo phosphorylation and Sonic hedgehog (Shh) pathway activation. Our study reveals a conserved mechanism whereby Hh induces a change in Smo subcellular localization to promote its association with and activation by a plasma membrane localized kinase, and provides new insight into how Hh morphogen progressively activates Smo.
Tong, Chao; Wang, Bing; Chen, Yongbin; Jiang, Jin
Hedgehog (Hh) signaling controls embryonic development and adult tissue homeostasis through the G protein coupled receptor (GPCR)-family protein Smoothened (Smo). Upon stimulation, Smo accumulates on the cell surface in Drosophila or primary cilia in vertebrates, which is thought to be essential for its activation and function, but the underlying mechanisms remain poorly understood. Here we show that Hh stimulates the binding of Smo to a plasma membrane-associated kinase Gilgamesh (Gish)/CK1γ and that Gish fine-tunes Hh pathway activity by phosphorylating a Ser/Thr cluster (CL-II) in the juxtamembrane region of Smo carboxyl-terminal intracellular tail (C-tail). We find that CL-II phosphorylation is promoted by protein kinase A (PKA)-mediated phosphorylation of Smo C-tail and depends on cell surface localization of both Gish and Smo. Consistent with CL-II being critical for high-threshold Hh target gene expression, its phosphorylation appears to require higher levels of Hh or longer exposure to the same level of Hh than PKA-site phosphorylation on Smo. Furthermore, we find that vertebrate CK1γ is localized at the primary cilium to promote Smo phosphorylation and Sonic hedgehog (Shh) pathway activation. Our study reveals a conserved mechanism whereby Hh induces a change in Smo subcellular localization to promote its association with and activation by a plasma membrane localized kinase, and provides new insight into how Hh morphogen progressively activates Smo. PMID:27280464
Full Text Available Hedgehog (Hh signaling regulates embryonic development and adult tissue homeostasis through the GPCR-like protein Smoothened (Smo, but how vertebrate Smo is activated remains poorly understood. In Drosophila, Hh dependent phosphorylation activates Smo. Whether this is also the case in vertebrates is unclear, owing to the marked sequence divergence between vertebrate and Drosophila Smo (dSmo and the involvement of primary cilia in vertebrate Hh signaling. Here we demonstrate that mammalian Smo (mSmo is activated through multi-site phosphorylation of its carboxyl-terminal tail by CK1α and GRK2. Phosphorylation of mSmo induces its active conformation and simultaneously promotes its ciliary accumulation. We demonstrate that graded Hh signals induce increasing levels of mSmo phosphorylation that fine-tune its ciliary localization, conformation, and activity. We show that mSmo phosphorylation is induced by its agonists and oncogenic mutations but is blocked by its antagonist cyclopamine, and efficient mSmo phosphorylation depends on the kinesin-II ciliary motor. Furthermore, we provide evidence that Hh signaling recruits CK1α to initiate mSmo phosphorylation, and phosphorylation further increases the binding of CK1α and GRK2 to mSmo, forming a positive feedback loop that amplifies and/or sustains mSmo phosphorylation. Hence, despite divergence in their primary sequences and their subcellular trafficking, mSmo and dSmo employ analogous mechanisms for their activation.
Zhang, Jie; Li, Xiang-An; Evers, B. Mark; Zhu, Haining; Jia, Jianhang
In Hedgehog (Hh) signaling, binding of Hh to the Patched-Interference Hh (Ptc-Ihog) receptor complex relieves Ptc inhibition on Smoothened (Smo). A longstanding question is how Ptc inhibits Smo and how such inhibition is relieved by Hh stimulation. In this study, we found that Hh elevates production of phosphatidylinositol 4-phosphate (PI(4)P). Increased levels of PI(4)P promote, whereas decreased levels of PI(4)P inhibit, Hh signaling activity. We further found that PI(4)P directly binds Smo through an arginine motif, which then triggers Smo phosphorylation and activation. Moreover, we identified the pleckstrin homology (PH) domain of G protein-coupled receptor kinase 2 (Gprk2) as an essential component for enriching PI(4)P and facilitating Smo activation. PI(4)P also binds mouse Smo (mSmo) and promotes its phosphorylation and ciliary accumulation. Finally, Hh treatment increases the interaction between Smo and PI(4)P but decreases the interaction between Ptc and PI(4)P, indicating that, in addition to promoting PI(4)P production, Hh regulates the pool of PI(4)P associated with Ptc and Smo. PMID:26863604
Full Text Available Zach Radcliff, Allison Baylor, Bruce Rybarczyk Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA Abstract: Sleep is a critical component of healthy development for youth, with cascading effects on youth’s biological growth, psychological well-being, and overall functioning. Increased sleep difficulties are one of many disruptions that adopted youth may face throughout the adoption process. Sleep difficulties have been frequently cited as a major concern by adoptive parents and hypothesized in the literature as a problem that may affect multiple areas of development and functioning in adopted youth. However, there is limited research exploring this relationship. Using a biopsychosocial framework, this paper reviews the extant literature to explore the development, maintenance, and impact of sleep difficulties in adopted youth. Finally, implications for future research and clinical interventions are outlined. Keywords: adoption, sleep, youth
Kemp, Matthew W; Lazarus, Benjamin M; Perron, Gabriel G; Hanage, William P; Chapman, Elaine
The ability to form multiple learning relationships is a key element of the doctoral learning environment in the biomedical sciences. Of these relationships, that between student and supervisor has long been viewed as key. There are, however, limited data to describe the student perspective on what makes this relationship valuable. In the present study, we discuss the findings of semi-structured interviews with biomedical Ph.D. students from the United Kingdom and the United States to: i) determine if the learning relationships identified in an Australian biomedical Ph.D. cohort are also important in a larger international student cohort; and ii) improve our understanding of student perceptions of value in their supervisory relationships. 32 students from two research intensive universities, one in the United Kingdom (n = 17), and one in the United States (n = 15) were recruited to participate in a semi-structured interview. Verbatim transcripts were transcribed, validated and analysed using a Miles and Huberman method for thematic analysis. Students reported that relationships with other Ph.D. students, post-doctoral scientists and supervisors were all essential to their learning. Effective supervisory relationships were perceived as the primary source of high-level project guidance, intellectual support and confidence. Relationships with fellow students were viewed as essential for the provision of empathetic emotional support. Technical learning was facilitated, almost exclusively, by relationships with postdoctoral staff. These data make two important contributions to the scholarship of doctoral education in the biomedical sciences. Firstly, they provide further evidence for the importance of multiple learning relationships in the biomedical doctorate. Secondly, they clarify the form of a 'valued' supervisory relationship from a student perspective. We conclude that biomedical doctoral programs should be designed to contain a minimum level of formalised
Surgical site infections (SSI) are a common complication after surgical procedures. To reduce the incidence of SSIs, Oakville Trafalgar Memorial Hospital decided to institute a bundle of initiatives to change multiple factors simultaneously based on best available evidence and the understanding of infection pathophysiology. We used National Surgical Quality Improvement Program data on the incidence of SSIs in our targeted and essentials, general surgery and orthopedic surgery cases before and after the implementation of an SSI reduction bundle. This article discusses whether the use of intervention bundles may assist in the reduction of a variety of postoperative surgical complications.
... for Educators Search English Español Medical Issues in Adoption KidsHealth / For Parents / Medical Issues in Adoption What's ... child, before, during, and after the adoption. Open Adoptions If you have an open or semi-open ...
Vorechovský, I; Benediktsson, K P; Toftgård, R
The patched/hedgehog/smoothened signalling pathway has been implicated in the development of sporadic tumours associated with the naevoid basal cell carcinoma (Gorlin) syndrome (NBCCS). Mutations in sporadic basal cell carcinomas (BCCs) of the skin and medulloblastomas have been found in genes encoding all three proteins of the pathway. A substantial proportion of breast carcinomas has recently been suggested to contain missense mutations in the human patched (PTCH) and sonic hedgehog (SHH) homologues. However, an independent study showed that the implicated mutation in SHH (H133Y) was absent in a large number of BCCs, medulloblastomas, breast, ovary and colorectal tumours. We searched for the H133Y SHH mutation in 84 primary breast carcinomas, but did not detect this change in any sample. In addition, a subset of 45 primary breast tumours was analysed for mutations in the PTCH coding region and 48 samples in previously implicated exons of human smoothened, but no mutations were found. Although our results do not exclude the presence of clonal alterations of these genes in a small proportion of breast carcinomas, these data do not support the existence of frequent mutations in genes encoding major protein partners of this signalling pathway. The absence of nucleotide changes in PTCH may point to another linked gene in the chromosome region 9q22-q23, previously suggested to contain a breast cancer susceptibility gene.
... Español Text Size Email Print Share Thinking About Adoption: FAQs Page Content By: Elaine Schulte, MD, MPH, ... Network . Q: What are the different types of adoption? A: Children can be adopted through the national ...
... Children > Family Life > Family Dynamics > Adoption & Foster Care Adoption & Foster Care Article Body Each year, many children join families through adoption and foster care. These families may face unique ...
Chor, Ka Ho Brian; Wisdom, Jennifer P.; Olin, Su-Chin Serene; Hoagwood, Kimberly E.; Horwitz, Sarah M.
Building on a narrative synthesis of adoption theories by Wisdom et al. (2013), this review identifies 118 measures associated with the 27 adoption predictors in the synthesis. The distribution of measures is uneven across the predictors and predictors vary in modifiability. Multiple dimensions and definitions of predictors further complicate measurement efforts. For state policymakers and researchers, more effective and integrated measurement can advance the adoption of complex innovations such as evidence-based practices. PMID:24740175
Chor, Ka Ho Brian; Wisdom, Jennifer P; Olin, Su-Chin Serene; Hoagwood, Kimberly E; Horwitz, Sarah M
Building on a narrative synthesis of adoption theories by Wisdom et al. (2013), this review identifies 118 measures associated with the 27 adoption predictors in the synthesis. The distribution of measures is uneven across the predictors and predictors vary in modifiability. Multiple dimensions and definitions of predictors further complicate measurement efforts. For state policymakers and researchers, more effective and integrated measurement can advance the adoption of complex innovations such as evidence-based practices.
... Care > Adopted Children & Discipline Family Life Listen Español Text Size Email Print Share Adopted Children & Discipline Page Content Article Body Some parents are hesitant to discipline the child they have adopted. They may set fewer limits than they would for a birth child. They ...
McIlvenny, Paul; Raudaskoski, Pirkko Liisa
in transnational adoption practice and representation. We present the results of our analysis of how the experiences of adoptive parents are (re)mediated in a Danish television documentary series following five prospective adoptive couples, not all of whom succeed in their 'quest' to adopt from abroad. Furthermore......, while crossing linguistic, sociocultural, kinship, racial, class and national boundaries in the process. By combining this qualitative approach with studies of governmentality we map out a set of analytical tools to examine the practices and micropolitics of adoptive parents and families, especially...
Lee, Richard M.
The number of transracial adoptions in the United States, particularly international adoptions, is increasing annually. Counseling psychology as a profession, however, is a relatively silent voice in the research on and practice of transracial adoption. This article presents an overview of the history and research on transracial adoption to inform counseling psychologists of the set of racial and ethnic challenges and opportunities that transracial adoptive families face in everyday living. Particular attention is given to emergent theory and research on the cultural socialization process within these families. PMID:18458794
Petersen, Liselotte; Sørensen, Thorkild I A
The Danish Adoption Register was established in 1963-1964 to explore the genetic and environmental contribution to familial aggregation of schizophrenia. The register encompass information on all 14,425 non-familial adoptions of Danish children legally granted in Denmark 1924-1947. It includes name and date of birth of each adoptee and his or her biological and adoptive parents, date of transfer to adoptive parents and date of formal adoption. The linkage to biological and adoptive parents is close to complete, even biological fathers are registered for 91.4% of the adoptees. Adoption registers are a unique source allowing disentangling of genetic and familial environmental influences on traits, risk of diseases, and mortality.
Fields, Eve S; Meuchel, Jennifer M; Jaffe, Chiara J; Jha, Manish; Payne, Jennifer L
We sought to evaluate the prevalence rate and factors associated with post adoption depression. One hundred and twelve adoptive mothers of infants under 12 months of age were recruited from local and national adoption organizations. A modified Edinburgh Postnatal Depression Scale (EPDS) and a questionnaire collecting medical and psychiatric history, perceived stress, and demographics were administered retrospectively. The rates of significant depressive symptoms (defined as EPDS >or=12) were calculated at three time points post adoption, and associations with specific clinical variables (personal or family psychiatric history, stress, and adjustment difficulty) were assessed. Eighty-six mothers were included. Rates of significant depressive symptoms (EPDS >or=12) were found in 27.9% of subjects at 0-4 weeks, 25.6% at 5-12 weeks, and 12.8% at 13-52 weeks post adoption. Significant depressive symptoms were not associated with personal or family psychiatric history but were associated with stress (p = 0.0011) and adjustment difficulties (p = 0.042) post adoption. Significant depressive symptoms were relatively common in adoptive mothers within the first year after adoption and were associated with environmental stress. Prospective studies are needed to confirm the existence of post adoption depression and the factors associated with it.
Petersen, Liselotte; Sørensen, Thorkild I A
The Danish Adoption Register was established in 1963-1964 to explore the genetic and environmental contribution to familial aggregation of schizophrenia.......The Danish Adoption Register was established in 1963-1964 to explore the genetic and environmental contribution to familial aggregation of schizophrenia....
Silverman, Arnold R.
Research on transracial adoption indicates that most minority children in transracial placement adjust very well to their mixed-race environments. Most transracial adoptees have a sense of identity with their racial heritage, but the strength of this identity depends, to a large degree, on the commitment of the adoptive parents to foster it.…
Jul 3, 1971 ... to consider their parenthood artificial and uncomfortable. Toussieng leads one to the conclusion that it is the adoptive parents' unresolved resistance to parenthood that con titutes the major factor in causing emotional disturb- ance in the adoptive child. In the course of treating emotionally disturbed young.
González-Gugel, Elena; Villa-Morales, María; Santos, Javier; Bueno, Maria José; Malumbres, Marcos; Rodríguez-Pinilla, Socorro María; Piris, Miguel Ángel; Fernández-Piqueras, José
Inappropriate activation of the GLI/hedgehog (GLI/Hh) signalling occurs in several human cancers, including haematological neoplasms. However, little is known about its relevance in precursor T-cell lymphoblastic lymphomas (T-LBL) development. Moreover, the mechanisms whereby GLI/Hh signalling is activated in haematological malignancies are not fully clear. Here, we show that the gene Smoothened (SMO), the only non-redundant gene of this pathway, is up-regulated in mouse and human T-LBL. Interestingly, down-regulation of micro-RNAs mmu-miR-30a and mmu-miR-141 as well as hsa-miR-193b clearly contributes to enhance the expression of this gene in mouse and human lymphomas and, subsequently, to activate the GLI/Hh signalling. Activation of the GLI/Hh signalling in T-LBL promotes cell survival and proliferation, since inhibition of the pathway using short-hairpin-RNA-mediated SMO knockdown, or cyclopamine as a specific antagonist, significantly reduces these cellular processes. These findings suggest that sustained SMO up-regulation may contribute to T-LBL development and advocate the use of specific SMO inhibitors or microRNAs-based therapies as an attractive possibility to treat an important subset of T-LBL.
U.S. Environmental Protection Agency — Adopt Your Watershed is a Website that encourages stewardship of the nation's water resources and serves as a national inventory of local watershed groups and...
Despite the numerous benefits of legume-based multiple cropping systems in soil fertility management, most smallholder sorghum farmers have not adopted them. The aim of this study was to examine socio-economic factors influencing adoption of legume-based multiple cropping systems among smallholder sorghum ...
Müller, Anders Riel
Som transnationalt adopteret vokser man ofte op med en fortælling om, at man er født i et fattigt land. Og at ens første forældre var fattige eller oplevede så store problemer, at de ikke så andre muligheder end at afgive en til adoption. Det er en historie, man bliver fortalt igen og igen. Og som...... man ender med at fortælle sig selv. Fattigdom er problemet. Adoption er løsningen. Eller er det?...
Agarwal, M.K.; Frambach, R.T.
Research on innovation adoption has suffered from a bias towards understanding the factors that affect the dichotomous adoption/non-adoption decision.Much less attention is devoted to the question why potential adopters fail to progress to the adoption stage from earlier stages in the decision
Bramlett, Matthew D.; Radel, Laura F.
Data from the 2011–2012 National Survey of Children’s Health and the 2013 National Survey of Children in Nonparental Care were used to fit a multinomial logistic model comparing three groups to those who never considered adoption: those who ever considered, but are not currently planning adoption; those planning adoption; and those who adopted. Adoption may be more likely when the caregiver is a nonkin foster parent, a foster care agency was involved, and/or financial assistance is available. Those with plans to adopt but who have not adopted may face adoption barriers such as extreme poverty, lower education and being unmarried. PMID:26949328
Rhea, Sally-Ann; Bricker, Josh B; Wadsworth, Sally J; Corley, Robin P
This paper describes the Colorado Adoption Project (CAP), an ongoing genetically informative longitudinal study of behavioral development. We describe the features of the adoption design used in CAP, and discuss how this type of design uses data from both parent-offspring and related- versus unrelated-sibling comparisons to estimate the importance of genetic and shared environmental influences for resemblance among family members. The paper provides an overview of CAP's history, how subjects were ascertained, recruited, and retained, and the domains of assessment that have been explored since the CAP's initiation in 1975. Findings from some representative papers that make use of data from CAP participants illustrate the study's multifaceted nature as a parent-offspring and sibling behavioral genetic study, a study that parallels a complimentary twin study, a longitudinal study of development, a source of subjects for molecular genetic investigation, and a study of the outcomes of the adoption process itself. As subjects assessed first at age 1 approach age 40, we hope the CAP will establish itself as the first prospective adoption study of lifespan development.
Descriptive statistics and multiple regression analysis were used to analyse the field data The identified cassava production technologies at different stages of adoption by the respondents are use of improved cassava cuttings, use of herbicides/pesticides, Alternate row/crop geometry in a cassava /maize/yam intercrop, ...
Adoption Of Improved Cassava Varieties Among Smallscale Farmers In Ikot Ekpene Agricultural Zone Of Akwa Ibom State, Nigeria. ... Global Approaches to Extension Practice: A Journal of Agricultural Extension. Journal Home ... Data were analyzed using descriptive statistics, and multiple regression analysis. Results ...
Siegel, Deborah H.
Unlike in the past, most adoption agencies today offer birth parents and adoptive parents the opportunity to share identifying information and have contact with each other. To understand the impacts of different open adoption arrangements, a qualitative descriptive study using a snowball sample of 44 adoptive parents throughout New England began…
Gritter, James L.
Building on previous books by the author, "Hospitious Adoption: How Hospitality Empowers Children and Transforms Adoption" examines the next step after open adoption. Gritter takes the approach that practicing goodwill, respect, and courage within the realm of adoption makes the process move smoother and enriches children's lives. Following a…
Müller, Anders Riel
Som transnationalt adopteret vokser man ofte op med en fortælling om, at man er født i et fattigt land. Og at ens første forældre var fattige eller oplevede så store problemer, at de ikke så andre muligheder end at afgive en til adoption. Det er en historie, man bliver fortalt igen og igen. Og so...
Aniebue, P N; Aniebue, U U
The study of the pattern and outcome of adoptions in Enugu, Nigeria in order to determine the challenges in the emerging adoption practice in the state. A retrospective analysis of adoption practices in Enugu Nigeria based on data from the National women's Commission. The National Women's Commission is the statutory body responsible for the documentation and follow-up of adoption in Enugu State. The characteristics of adopters and adoptees, types of adoption, prevalence and outcome of the adoptions between January 1991 and December 2001 were examined. Percentages were used for descriptive statistics and student's t-test for comparing means at 5% significance levels. There were sixty-one adoptions in the eleven-year period giving a prevalence of 5.5 adoptions per year. Eighteen (29.5%) kinship adoptions and 43 (70.5%) adoptions of abandoned babies and children were recorded. The mean age of the adoptees was 4.2 years and 33.3% of them were 5 years and above. All adopters were Nigerians but 32.0% of them resided overseas. The commonest age range at adoption was 4-49 years and the peak duration of marriage prior to adoption was 15-19 years. Most adopters (84.9%) had at least secondary school education. No adoption was annulled and there was no recorded death of adoptees. Post care monitoring was found to be incomprehensive. The growing practice of adoption in Enugu is laudable but post adoption care is poor. Emphasis on post adoption care is vital in developing countries where complex social and logistic factors militate against it. In infertility management early institution of counseling on adoption would allow couples ample time for decision making and preparation for adoption, as well as encourage adoption when couples are still young.
Montgomery, Scott R; Nargizyan, Taya; Meliton, Vicente; Nachtergaele, Sigrid; Rohatgi, Rajat; Stappenbeck, Frank; Jung, Michael E; Johnson, Jared S; Aghdasi, Bayan; Tian, Haijun; Weintraub, Gil; Inoue, Hirokazu; Atti, Elisa; Tetradis, Sotirios; Pereira, Renata C; Hokugo, Akishige; Alobaidaan, Raed; Tan, Yanlin; Hahn, Theodor J; Wang, Jeffrey C; Parhami, Farhad
Osteogenic factors are often used in orthopedics to promote bone growth, improve fracture healing, and induce spine fusion. Osteogenic oxysterols are naturally occurring molecules that were shown to induce osteogenic differentiation in vitro and promote spine fusion in vivo. The purpose of this study was to identify an osteogenic oxysterol more suitable for clinical development than those previously reported, and evaluate its ability to promote osteogenesis in vitro and spine fusion in rats in vivo. Among more than 100 oxysterol analogues synthesized, Oxy133 induced significant expression of osteogenic markers Runx2, osterix (OSX), alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteocalcin (OCN) in C3H10T1/2 mouse embryonic fibroblasts and in M2-10B4 mouse marrow stromal cells. Oxy133-induced activation of an 8X-Gli luciferase reporter, its direct binding to Smoothened, and the inhibition of Oxy133-induced osteogenic effects by the Hedgehog (Hh) pathway inhibitor, cyclopamine, demonstrated the role of Hh pathway in mediating osteogenic responses to Oxy133. Oxy133 did not stimulate osteogenesis via BMP or Wnt signaling. Oxy133 induced the expression of OSX, BSP, and OCN, and stimulated robust mineralization in primary human mesenchymal stem cells. In vivo, bilateral spine fusion occurred through endochondral ossification and was observed in animals treated with Oxy133 at the fusion site on X-ray after 4 weeks and confirmed with manual assessment, micro-CT (µCT), and histology after 8 weeks, with equal efficiency to recombinant human bone morphogenetic protein-2 (rhBMP-2). Unlike rhBMP-2, Oxy133 did not induce adipogenesis in the fusion mass and resulted in denser bone evidenced by greater bone volume/tissue volume (BV/TV) ratio and smaller trabecular separation. Findings here suggest that Oxy133 has significant potential as an osteogenic molecule with greater ease of synthesis and improved time to fusion compared to previously studied oxysterols. Small
Denne rapport er en systematisk forskningsoversigt over udenlandske erfaringer med adoption i forhold til anbringelse uden for hjemmet, fx familiepleje, institutionsanbringelse og hjemgivelse til de biologiske forældre. Konklusionerne i rapporten er overraskende entydige: Adopterede børn klarer sig...... barn adopteres, jo mere stabil og uproblematisk bliver relationen mellem barn og adoptivforældre. Samtidig peger undersøgelserne på, at adoptioner med høj grad af åbenhed og kontakt mellem barn, adoptivforældrene og de biologiske forældre fungerer bedst. Hermed rokkes ved en udbredt forestilling om...
Christoffersen, Mogens; Hammen, Ida; Raft Andersen, Karen
Denne rapport er en systematisk forskningsoversigt over udenlandske erfaringer med adoption i forhold til anbringelse uden for hjemmet, fx familiepleje, institutionsanbringelse og hjemgivelse til de biologiske forældre. Konklusionerne i rapporten er overraskende entydige: Adopterede børn klarer sig...... barn adopteres, jo mere stabil og uproblematisk bliver relationen mellem barn og adoptivforældre. Samtidig peger undersøgelserne på, at adoptioner med høj grad af åbenhed og kontakt mellem barn, adoptivforældrene og de biologiske forældre fungerer bedst. Hermed rokkes ved en udbredt forestilling om...
Maria Acciaiuoli Barbosa-Ducharne
Full Text Available Abstract Communication about adoption is a family interaction process which is more than the simple exchange of information. Adoption communication can be characterized in terms of the level of openness of family conversations regarding the child’s past and the degree of the family’s adoption social disclosure. The objective of this study is to explore the process of adoption communication openness in Portuguese adoptive families by identifying the impact of variables related to the adoption process, the adoptive parenting and the adoptee. One hundred twenty five parents of children aged 3 to 15, who were adopted on average 4 years ago, participated in this study. Data was collected during home visits using the Parents Adoption Process Interview. A cluster analysis identified three different groups of families according to the level of adoption communication openness within the family and outside. The findings also showed that the process of the adoption communication openness started when parents decided to adopt, developed in parent-child interaction and was susceptible to change under professional intervention. The relevance of training given to prospective adopters and of professional practice based on scientific evidence is highlighted.
Jenista, Jerri Ann
As international adoption has become more "mainstream," the issues recently addressed in domestic adoption have become more important in adoptions involving children originating in other countries. Certain groups of prospective adoptive parents, such as gay or lesbian couples, single parents, and parents with disabilities, have begun to apply to adopt in ever increasing numbers. Children who may have been considered unadoptable in the past are now routinely being offered to prospective adoptive parents. The numbers and ages of the children placed and the spacing between adoptions have come under scrutiny. The rates of adoption dissolutions and disruptions are being examined carefully by the receiving and sending countries. There is a pressing need for research into numerous social aspects of adoption.
Wang, Bill B; Wan, Thomas T H; Burke, Darrell E; Bazzoli, Gloria J; Lin, Blossom Y J
To study the number of health information systems (HISs), applicable to administrative, clinical, and executive decision support functionalities, adopted by acute care hospitals and to examine how hospital market, organizational, and financial factors influence HIS adoption. A cross-sectional analysis was performed with 1441 hospitals selected from metropolitan statistical areas in the United States. Multiple data sources were merged. Six hypotheses were empirically tested by multiple regression analysis. HIS adoption was influenced by the hospital market, organizational, and financial factors. Larger, system-affiliated, and for-profit hospitals with more preferred provider organization contracts are more likely to adopt managerial information systems than their counterparts. Operating revenue is positively associated with HIS adoption. The study concludes that hospital organizational and financial factors influence on hospitals' strategic adoption of clinical, administrative, and managerial information systems.
Anderson, Megan; Comrie, Rhonda
In 1999, the American Society of Anesthesiologists adopted preoperative fasting guidelines to enhance the quality and efficiency of patient care. Guidelines suggest that healthy, non-pregnant patients should fast six hours from solids and two hours from liquids. Although these guidelines are in place, studies suggest that providers are still using the blanket statement "NPO after midnight" without regard to patient characteristics, the procedure, or the time of the procedure. Using theory to help change provider's beliefs may help make change more successful. Rogers' Theory of Diffusion of Innovations can assist in changing long-time practice by laying the groundwork for an analysis of the benefits and disadvantages of proposed changes, such as changes to fasting orders, while helping initiate local protocols instead of additional national guidelines.
Grow, Lucille J.; Shapiro, Deborah
The purpose of this study was to examine the interaction of 38 pairs of white adoptive parents of black children and their social agencies, from the viewpoint of the parents and agency workers. A secondary study compared the characteristics of more recent transracial adopters with those of 125 families who had adopted transracially in the past.…
This research examines post-adoption behavior (discontinuance versus continuance) with the context of Intranet use. Multiple theories are used as theoretical frameworks to extend information communication technology research to the case of post-adoption behavior. Three research questions and six sets of hypotheses are formulated to distinguish…
This paper analyzes the synergies/tradeoffs involved in the adoption of improved varieties of multiple crops in the mixed crop-livestock production systems of the highlands of Ethiopia A multivariate probit (MVP) model involving a system of four equations for the adoption decision of improved varieties of barley, potatoes, ...
Simon, Rita J.; Alstein, Howard
Describes the rhetoric and goals of groups who have opposed and supported transracial adoption in the United States. Summarizes the current status of statutory and case law bearing on transracial adoption, and presents the results of a longitudinal study of families who adopted children of another race. (TJQ)
Technology adoption has played a key role in the global development and increase in agricultural productivity. However, the decision to adopt a new technology on farms is complex. While the factors that drive the adoption of new technologies have been well studied in agriculture, less attention has ...
Palabindala, Venkataraman; Pamarthy, Amaleswari; Jonnalagadda, Nageshwar Reddy
Electronic health records (EHR) are not a new idea in the U.S. medical system, but surprisingly there has been very slow adoption of fully integrated EHR systems in practice in both primary care settings and within hospitals. For those who have invested in EHR, physicians report high levels of satisfaction and confidence in the reliability of their system. There is also consensus that EHR can improve patient care, promote safe practice, and enhance communication between patients and multiple ...
This article develops a model of the innovation-adoption decision. The model allows the economic situation of a utility and its perception of uncertainty associated with an innovation to affect the probability of adopting it. This model is useful when uncertainties affecting decisions about adoption persist throughout the diffusion process, thereby making the usual adoption model implicit in rate-of-diffusion studies inappropriate. An empirical test of the model finds that firm size, power pool size, and selected aspects of uncertainty about the innovation are significant predictors of US utility companies' decisions on whether or not to adopt nuclear power generation. 17 references, 2 tables
Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations...
Sitorus, Hotna M.; Govindaraju, Rajesri; Wiratmadja, I. I.; Sudirman, Iman
The success of a new technology depends on how well it is accepted by its intended users. Many technologies face the problem of low adoption rate, despite the benefits. An understanding of what makes people accept or reject a new technology can help speed up the adoption rate. This paper presents a framework for technology adoption based on an interactive perspective, resulting from a literature study on technology adoption. In studying technology adoption, it is necessary to consider the interactions among elements involved in the system, for these interactions may generate new characteristics or new relationships. The interactions among elements in a system adoption have not received sufficient consideration in previous studies of technology adoption. Based on the proposed interaction perspective, technology adoption is elaborated by examining interactions among the individual (i.e. the user or prospective user), the technology, the task and the environment. The framework is formulated by adopting several theories, including Perceived Characteristics of Innovating, Diffusion of Innovation Theory, Technology Acceptance Model, Task-Technology Fit and usability theory. The proposed framework is illustrated in the context of mobile banking adoption. It is aimed to offer a better understanding of determinants of technology adoption in various contexts, including technology in manufacturing systems.
Zhang, Yuanting; Lee, Gary R.
The United States is one of the major baby-receiving countries in the world. Relatively little research has focused on why there is such a high demand for intercountry adoption. Using in-depth qualitative interviews with adoptive parents, the authors explored the reasons why Americans prefer to adopt foreign-born children instead of adopting…
Problemas multiplicativos envolvendo combinatória: estratégias de resolução empregadas por alunos do Ensino Fundamental público Multiplicative problems including combinatorics: solving strategies adopted by Public Elementary School students
Leny R. M. Teixeira
Full Text Available Neste trabalho apresentamos os dados de uma pesquisa que teve por objetivo verificar o desempenho de alunos do 6.° ao 9.° anos do Ensino Fundamental na resolução de oito problemas multiplicativos, envolvendo raciocínio combinatório. Os problemas diferiam em relação à quantidade de variáveis e à quantidade de algarismos utilizados nos fatores. Para tanto, por meio de uma entrevista clínica levantamos as principais estratégias e erros produzidos por 40 alunos de duas escolas públicas (A e B da cidade de Campo Grande-MS, as quais fizeram parte de uma pesquisa mais ampla realizada anteriormente. Os dados revelam que o desempenho foi melhor nos problemas com duas variáveis e com fatores de valores baixos, não havendo diferença de desempenho entre alunos do 6.° e do 9.° anos. De modo geral, as dificuldades que emergiram estavam relacionadas: 1 aos modelos intuitivos que os alunos têm a respeito da multiplicação (em especial o da soma repetida; 2 a estrutura semântica do problema; 3 as preferências numéricas quanto ao tamanho dos números, formas de representar o problema e interpretação do enunciado verbal. Por ser a multiplicação uma operação bastante complexa envolvendo, em sua resolução, processos cognitivos abstratos, acreditamos que o professor precisa conhecê-los para favorecer a aprendizagem dos alunos.This work presents data from a study which aimed at verifying the performance of Elementary School 6th and 9th graders when solving eight multiplicative problems involving combinatorial thinking. The problems were different concerning the amount of variables and the amount of numerical digits used in factors. Therefore, through a clinical interview, we listed the main strategies and mistakes produced by 40 graders from two public schools (A and B in the municipality of Campo Grande (Mato Grosso do Sul - MS - State which were part of a larger research developed before. The observations reveal that the performance
Offenberg, Joachim; Peng, Renkang; Nielsen, Mogens Gissel
Incipient ant colonies are often under fierce competition, making fast growth crucial for survival. To increase production, colonies can adopt multiple queens (pleometrosis), fuse with other colonies or rob brood from neighboring colonies. However, different adoption strategies might have different...
Norbayah BTE MOHD SUKI
Full Text Available Online shopping represents an innovation to be adopted or rejected by online consumersglobally. Previous experiences and knowledge of innovation are the main factors affectingpeopleâs willingness to adopt a new innovation. We explore how Internet use differsbetween academicians who are innovative adopters and other types of adopters.Academicians who are innovative adopters are hypothesized to: have more years of experience on online shopping, have greater frequency of purchase, and pay a higher price for items purchased online.Data were collected from 301 respondents. Results provide new perspective on innovativeadopters among Malaysian academicians; they have less experience than other adopters inshopping for products online, make fewer purchases online and pay small amount ofmoney in shopping for products online than other adopters. Directions for future research are also discussed.
Goldstein, Jesse A; Brown, Benjamin J; Mason, Patrick; Basci, Deniz; Hindenburg, Lora; Dufresne, Craig R; Baker, Stephen B
Standards of cleft care abroad differ from those in the United States, particularly in less developed countries, where international adoption rates are high. Children adopted from these countries present to plastic surgeons in the United States at various ages and states of repair. The operative and perioperative needs of these children are poorly understood. This study attempts to characterize the preadoption history, the postadoption course, and surgical outcomes of children adopted with cleft deformities. The authors performed a retrospective review of all adopted cleft lip-cleft palate patients presenting to an academic craniofacial referral center and compared outcomes among adopted children who were repaired abroad, adopted children who underwent repair performed by the two senior authors (C.R.D. and S.B.B.), and children born in the United States who underwent repair performed by one of the senior authors (S.B.B.) : Between May of 1993 and August of 2010, 83 adopted children with cleft deformities were evaluated in the authors' craniofacial center. Average age at adoption was 30.5 months (range, 5.0 to 95.0 months). Comparing outcomes among adopted children repaired abroad, adopted children repaired by the senior authors, and children born in the United States who underwent repair in the United States, the authors found no statistically significant differences in lip revision rates, fistula rates, or velopharyngeal insufficiency. Adopted cleft patients constitute a complex and variable population with high rates of revision and delayed presentation. Internationally adopted children with orofacial clefts fared no better or worse after undergoing primary cleft repair abroad or in the United States.
This study utilized a newly developed handset-based mobile end-user research platform and obtained data from 548 Finnish smartphone users in 2006. In addition to descriptive adoption statistics, a path analysis model is developed that explains mobile service adoption contingent on a set of explanatory variables. The paper finds that user intentions have a strong impact on consequent adoption of the service. What is more, perceived hedonic benefits from the service are the strongest factor dri...
The controversies in adoption have extended across a spectrum of policy and practice issues, and although the issues have become clear, resolution has not been achieved nor has consensus developed regarding a framework on which to improve the quality of adoption policy and practice. This book is the fourth in a series to use an ethics-based…
Scripcaru, G; Pirozynski, T; Pirozynski, M
The authors analyse child adoption and the problems of the adopted child through briefing the juridic (legal) regulations ot this institution as well as the many medical and psychologic aspects regarding the relationships that condition its success. At the same they present the semiological aspects induced by the failure of adoption investigated under the aspect of motivation and the manifestations of certain reactive psychosyndromes of the adopted child. The authors' intention and the aim of the paper is to institutionalize a certain medical and psychological delivery according to the knowledge of the many relational implications of child adoption and--without the tendency to 'psychiatrize'--in order to promote the success conveyed to the humanistic content of this institution.
This paper is based on a Norwegian study that addressed the importance of nurses understanding adoptive families' particular needs. The study aimed to provide a diverse picture of adoptive families' challenges and resources. It addressed adoptive families' experiences with welfare professions, particularly public health nurse services, and explored their need for support before and after adoption. This paper focuses particularly on challenges confronting 'transracial' families. The qualitative research interview was used as the methodological approach. Nine couples of adoptive parents, four adoptive mothers, three public health nurses and four adult adoptees were interviewed. The analysis process was an ad hoc generation of meaning, and the data were systematically reviewed and categorized through an intuitive analysis style. The study indicates that adoptive families manage their 'most common' challenges on their own, but the informants also spoke about a need for professional support and assistance in many cases. Recurring themes in the study were challenges linked to 'attachment difficulties', 'external categorization', 'grief' and 'the meaning of biological heritage and roots'. Findings indicate that there is a substantial demand for increased knowledge of adoptive families' special needs, not least in the public health nurse services; there is also limited knowledge within other welfare professions. Nurses particularly need to strengthen their understanding on how external categorization affects transracial adoptive families. The study recommendations call for improved follow-up after adoptions. This can be met by establishing a special programme for adoptive families at maternity and child health centres. In addition, public health nurses can support adoptees in their teenage years through individual consultations.
Martin, Nina A; Hulland, Kristyna R S; Dreibelbis, Robert; Sultana, Farhana; Winch, Peter J
To understand factors that influence sustained adoption of water, sanitation and hygiene (WASH) technologies or behaviours. Systematic review of the current literature. Articles were gathered from databases of peer-reviewed articles and grey literature, and screened for relevance. After exclusion, we created a descriptive map of 148 articles and analysed in-depth 44 articles that had an explicit focus on promoting or evaluating sustained adoption or programme sustainability. Twenty-two of these articles met our definition of measuring sustained adoption. Definitions of sustained adoption varied widely and were often inadequate, making comparison of sustained adoption across studies difficult. The time frame for measurements of sustained adoption is frequently inadequate for examination of longer-term behaviour change. Ideally, an evaluation should specify the project period and describe the context surrounding adoption, make measurements at multiple time points, diversify measurement methods and describe and measure a range of factors affecting sustained adoption. Additional consideration needs to be given to developing behaviour change models that emphasise factors related to sustained adoption, and how they differ from those related to initial adoption. © 2017 John Wiley & Sons Ltd.
Discusses areas of revision on the 1996 British Government's Draft Adoption Bill: aspects of the welfare principles; criteria for dispensing with parental consent; orders for stepparents; and the use of residence orders as an alternative to adoption. Concludes that resolving those issues would be an important step toward meeting the diverse needs…
Frandsen, Sanne; Morsing, Mette; Vallentin, Steen
Purpose – The purpose of this paper is to explore the relationship between sustainability adoption and internal legitimacy construction. Design/methodology/approach – The paper is designed as a critical inquiry into existing research and practice on sustainability adoption, illustrated by two cor...
Zuniga, Maria E.
Outlines the racial and cultural identity needs of minority group children adopted by white parents. Discusses the social worker's role in educating adoptive parents about these needs and how they can be met through the neighborhood, the school, the church, friendship systems, and recreational activities. Contains 29 references. (SV)
Supporters and opponents of transracial adoption agree that minority children have a right and a need to develop a sense of ethnic identity and a knowledge of their cultural heritage. Maintains that questionable social and psychiatric assumptions are used to justify this position and deny the legitimacy of transracial adoption. (MDM)
Despite the significant number of transracial Aboriginal adoptions that have taken place in Canada, little research is available that addresses the psychological and psychosocial ramifications for the children involved. The scant literature that does exist raises concerns about the psychological impact of this type of adoption. The present…
The author discusses the advantages and disadvantages of the adoption of black children by white parents. He concludes that until empirical studies are made, placements should not proceed as if it had already been ascertained that transracial adoption is beneficial. (Author/BW)
The number of international adoptions, many from developing countries, has doubled in the last 10 years. This podcast discusses ways adoptive families can protect their own health and the health of their new children. Created: 10/22/2007 by National Center for the Prevention, Detection and Control of Infectious Diseases (NCPDCID). Date Released: 10/24/2007.
Miller, Laurie C
Nearly 220,000 children have been adopted from other countries by American parents since 1986. Approximately 65,000 children have arrived from China and Russia, mostly in the past 6 years. Most of these children reside in orphanages before adoption, where they may experience malnutrition, environmental deprivation, neglect, and exposure to infectious diseases. After arrival to the United States, international adoptees should undergo specialized screening evaluation for infectious diseases and other conditions. Infectious conditions of special concern include hepatitis B and C, syphilis, human immunodeficiency virus infection, tuberculosis, and presence of intestinal parasites. Before the adoption occurs, the infectious disease consultant may be asked to assist the primary care provider and the adoptive family with advice about travel and review of preadoptive medical records. After the adoption, the infectious diseases consultant may be asked to assess the adequacy of the child's vaccination record from the birth country and to assist in screening, evaluation, and management of infectious diseases.
Rebane, Kaja L.; Barham, Bradford L.
Solar home systems (SHSs) are a promising electrification option for many households in the developing world. In most countries SHSs are at an early stage of dissemination, and thus face a hurdle common to many emerging alternative energy technologies: many people do not know enough about them to decide whether to adopt one or not. This study uses survey data collected in Nicaragua to investigate characteristics that predict the knowledge and adoption of SHSs among the rural population. First, a series of probit models is used to model the determinants of four measures of SHS knowledge. Next, a biprobit model with sample selection is employed to investigate the factors that predict SHS adoption, conditional on having sufficient knowledge to make an adoption decision. Comparison of the biprobit formulation to a standard probit model of adoption affirms its value. This study identifies multiple determinants of SHS knowledge and adoption, offers several practical recommendations to project planners, and provides an analytical framework for future work in this policy-relevant area. - Research highlights: → Solar home systems (SHSs) are a promising rural electrification option in the developing world. → As with many emerging renewable energy technologies, lack of knowledge may limit SHS adoption. → We use probit models to investigate the determinants of SHS knowledge in rural Nicaragua. → We also employ a biprobit model linking the determinants of knowledge and adoption. → We find that in analyzing SHS adoption, accounting for sample selection based on knowledge is key.
Stone, Gerald C.; And Others
Reports the results of an analysis of appearance characteristics of a sample of joint ownership newspapers, which yielded information about factors related to the adoption of modern newspaper design. (GT)
Full Text Available This paper addresses the adoption of the Euro currency in 2014, as estimated in the National Programme. Based on the convergence criteria analysis on the current national background, we can foresee an earlier monetary integration.
Raudaskoski, Pirkko Liisa
The paper discusses an empirical analysis which highlights the multimodal nature of identity construction. A documentary on transnational adoption provides real life incidents as research material. The incidents involve (or from them emerge) various kinds of multimodal resources and participants...
Ma, Zheng; Jørgensen, Bo Nørregaard; Asmussen, Alla
company and one electricity retailer, this paper investigates the factors that influence industrial consumers’ acceptance of smart grid solutions, and how the influential factors are relevant to the smart grid adoption phases. Eleven influential factors are identified that impact on four stages...... for industrial consumers’ adoption of smart grid solutions (inscription, translation, framing, and stabilization stages). The eleven influential factors are: awareness of multiple contexts, shared support, return-of-investment, ease of use, flexibility and dynamic pricing, liberalization and energy tariff...
Full Text Available There are many factors that can affect the process of adopting Agile methods during software developing. This paper illustrates the critical factors in Agile methods adoption in software organizations. To present the success and failure factors, an exploratory study is carried out among the critical factors of success and failure from existing studies. Dimensions and Factors are introduced utilizing success and failure dimensions. The mind map was used to clarify these factors.
G.O. Ofori-Dwumfuo; Betty A. Dankwah
This study looks at the benefits, challenges and barriers in adopting Internet banking at a major bank in Ghana. The development of the Internet is changing the way financial services are provided in Ghana. The Internet banking facility has resulted in new ways of delivering banking services. The research is a case study based on the staffs that has worked with the bank for more than three years. In evaluating benefits, challenges and barriers to the bank in adopting Internet banking, intervi...
EGBUNIKE Patrick Amaechi
Full Text Available Purpose of the article: The purpose of this paper is to consider why firms find it challenging to adopt environmental accounting. The authors argue that environmental accounting is one of the important vehicles corporate bodies utilize in communicating with the external world. With the increase in complexities of the business world, the role of environmental information has been gradually increasing for making economic decision. Methodology/methods: The research is exploratory in nature and only considers a small subset of Nigerian firms. However, several firms may be faced with varied challenges of adopting environmental accounting. The authors used four hundred (400 questionnaires and data obtained from the field survey was analyzed using t-values. Scientific aim: The paper examined the adoption challenges of environmental accounting among Nigerian firms. Findings: The study found that lack of environmental awareness by employees, shortage of environmental information and higher adaptation costs hinders environmental accounting adoption in Nigeria. Moreover, there are no clear-cut guidelines of environmental accounting on issues such as environmental costs, assets, liabilities, recognition and measurement of such costs. Conclusions: Government and accounting regulatory bodies should play more active role in the development of environmental accounting and reporting guidelines by making it reliable and relevant to users. As a matter of fact, there should be a deadline imposed on Nigerian companies to fully adopt and implement environmental reporting guidelines. In addition, employees should be trained on environmental reporting techniques.
Vermeulen, Walter J.V.; Hovens, Jeroen
An integrative model to explain potential adopters' decisions to adopt energy innovations was adapted and applied in the field of new office building construction. We tested the relative effects of competing theoretical explanations (derived from economics, innovation science and policy science) on the decision to adopt. The research covered 35 projects representing 9% of the total volume of new office construction in the Netherlands between 2000 and mid-2002. Two levels of explanations for adopting innovations were derived: (a) the potential adopter's weighed assessments of the innovations and his or her nature of decision making and (b) explanation of those first-level variables. Using multiple regression techniques, we determined the relative influence on innovation-adoption of variables covering economy and technology, government intervention, company characteristics, and influences from market and society. The decision to adopt 'mature' innovations, in contrast to 'young' innovations, is based more on routine procedures than project-specific considerations. Policies need to take this difference into consideration. We also show evidence that in promoting adoption of E-innovations for new office buildings the Dutch system of applying Energy Performance Standards and subsidies proofs to be effective
Westermeyer, Joseph; Yoon, Gihyun; Amundson, Carla; Warwick, Marion; Kuskowski, Michael A
The goal of this epidemiological study was to investigate lifetime history and odds ratios of personality disorders in adopted and non-adopted adults using a nationally representative sample. Data, drawn from the National Epidemiological Survey on Alcohol and Related Conditions (NESARC), were compared in adopted (n=378) versus non-adopted (n=42,503) adults to estimate the odds of seven personality disorders using logistic regression analyses. The seven personality disorders were histrionic, antisocial, avoidant, paranoid, schizoid, obsessive-compulsive, and dependent personality disorder. Adoptees had a 1.81-fold increase in the odds of any personality disorder compared with non-adoptees. Adoptees had increased odds of histrionic, antisocial, avoidant, paranoid, schizoid, and obsessive-compulsive personality disorder compared with non-adoptees. Two risk factors associated with lifetime history of a personality disorder in adoptees compared to non-adoptees were (1) being in the age cohort 18-29 years (but no difference in the age 30-44 cohort), using the age 45 or older cohort as the reference and (2) having 12 years of education (but no difference in higher education groups), using the 0-11 years of education as the reference. These findings support the higher rates of personality disorders among adoptees compared to non-adoptees. Published by Elsevier Ireland Ltd.
Raudaskoski, Pirkko; McIlvenny, Paul
In recent years, fields such as discursive psychology have paid attention to the social, instead of solely individual, character of emotions, bringing to the fore the interactional organisation of affect displays. In the same vein, other ‘inner’ processes, such as memory, are studied from...... of this research is to better understand the relationships between multimodality, embodiment, interaction and affect. We present the results of our analysis of how the experiences of adoptive parents are (re)mediated in a Danish television documentary series following five prospective adoptive couples, not all......). In this setting, the participants use language and other mediational means (eg. telephone, speakerphone, written details about the child, photograph, pen, paper) to accomplish the joint receipt of news about the child-to-be-adopted. In the analysis, we concentrate on how the parents’ affective displays...
Full Text Available Agile software development can be made successful, but there is no well-defined way how to achieve this. The problem is that the successful adoption of agile methods and practices is a complex process and this process should be customizable for a particular organization or a team. This research focuses on identification of agile methods and practices. Result of the research is the ranking of agile methods, practices and their usage trends. As some terms of agile software development are interpreted differently in different organizations and teams, terminology used is analyzed. Results of the research can be used as a reference material for those who are planning to adopt agile methods or are looking for the next agile practice to implement. Results will be used for the development of an expert system to support agile adoption.
Purpose - Proposes providing an insight about factors affecting business-to-business e-commerce adoption and implementation in small to medium-sized enterprises (SMEs), highlighting similarities and differences between Danish and Australian SMEs. Design/methodology/approach - The research...... is based on a wide literature review, focused on proposing a theoretical model of technological, environmental and organizational factors influencing e-commerce adoption and implementation. Subsequently, a questionnaire based on the research model has been developed and face-to-face interviews were...... conducted in Danish and Australian companies. Findings - The findings both corroborate previous results about significant factors affecting SMEs' b-to-b e-commerce adoption and implementation and provide new, interesting insights. The study also finds many similarities and differences between Denmark...
-, č. 414 (2010), s. 1-61 ISSN 1211-3298 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:MSM0021620846 Keywords : technology adoption * stagnation * economic integration * political fragmentation Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp414.pdf
Penjor, Sonam; Zander, Pär-Ola Mikael
This study investigates the significance of Rogers’ Diffusion of Innovations (DOI) theory with regard to the use of a Virtual Learning Environment (VLE) at the Royal University of Bhutan (RUB). The focus is on different adoption types and characteristics of users. Rogers’ DOI theory is applied...
Kruse, Clemens Scott; Kristof, Caitlin; Jones, Beau; Mitchell, Erica; Martinez, Angelica
Federal efforts and local initiatives to increase adoption and use of electronic health records (EHRs) continue, particularly since the enactment of the Health Information Technology for Economic and Clinical Health (HITECH) Act. Roughly one in four hospitals not adopted even a basic EHR system. A review of the barriers may help in understanding the factors deterring certain healthcare organizations from implementation. We wanted to assemble an updated and comprehensive list of adoption barriers of EHR systems in the United States. Authors searched CINAHL, MEDLINE, and Google Scholar, and accepted only articles relevant to our primary objective. Reviewers independently assessed the works highlighted by our search and selected several for review. Through multiple consensus meetings, authors tapered articles to a final selection most germane to the topic (n = 27). Each article was thoroughly examined by multiple authors in order to achieve greater validity. Authors identified 39 barriers to EHR adoption within the literature selected for the review. These barriers appeared 125 times in the literature; the most frequently mentioned barriers were regarding cost, technical concerns, technical support, and resistance to change. Despite federal and local incentives, the initial cost of adopting an EHR is a common existing barrier. The other most commonly mentioned barriers include technical support, technical concerns, and maintenance/ongoing costs. Policy makers should consider incentives that continue to reduce implementation cost, possibly aimed more directly at organizations that are known to have lower adoption rates, such as small hospitals in rural areas.
... Adoption Directory Search National Foster Care & Adoption Directory Search Many concerned individuals have expressed the desire to ... how to become a foster or adoptive parent. Search results for this category include contact information for: ...
... Birth parents can benefit from information about the advantages of open adoption for children. The number of ... mediator) are on the rise. In a 2012 survey of adoption agencies with infant adoption programs, agencies ...
Levey, Janet A
The purpose of the study was to examine the characteristics and relationships of nurse educators' teaching practices, knowledge, support, and willingness to adopt inclusive teaching strategies (WillAdITS). Adopting more inclusive teaching strategies based on universal design for instruction is an innovative way for educators to reach today's diverse student body. However, the pedagogy has not diffused into nursing education. Descriptive statistics and hierarchical multiple regression were used for analyzing data from 311 nurse educators in prelicensure and RN to BSN programs. The model explained 44.8 percent of the variance in WillAdITS. The best indicators for this pedagogy were knowledge of universal design for instruction, social system support for inclusive teaching strategies, multiple instructional formats, and years of teaching. Knowing factors influencing the adoption of inclusive teaching strategies can inform schools of nursing of areas needing further development in the preparation of novice to experienced educators to teach diverse learners.
Murphy, Natalie L
Americans have increasingly turned to international adoption (IA) as an alternative way to build a family. Unfortunately, IA families are often being developed under conditions of loss, and sometimes these families struggle to form healthy attachments to each other. Disordered attachment (the failure to form a reciprocal, loving bond between parent and child) can occur, and can have devastating consequences. In some instances, IA children have been relinquished into state foster care systems; other families simply struggle for years caring for a developmentally delayed child who appears to have no emotion for his/her adoptive family. Nurses are likely to have contact with IA families and can use their education about attachment and bonding to help facilitate attachment in these developing families. Swanson's caring theory provides a clinically useful guide to meet this need.
LaMarche, Janelle [Fraunhofer Center for Sustainable Energy Systems, Cambridge, MA (United States); Cheney, K. [Fraunhofer Center for Sustainable Energy Systems, Cambridge, MA (United States); Akers, C. [Fraunhofer Center for Sustainable Energy Systems, Cambridge, MA (United States); Roth, K. [Fraunhofer Center for Sustainable Energy Systems, Cambridge, MA (United States); Sachs, O. [Fraunhofer Center for Sustainable Energy Systems, Cambridge, MA (United States)
The focus of this project was to investigate the factors influencing consumer adoption of Home Energy Displays (HEDs) and to evaluate electricity consumption in households with basic HEDs versus enhanced feedback methods - web portals or alerts. The team hypothesized that providing flexible and relatable information to users, in addition to a basic HED, would make feedback more effective and achieve persistent energy savings. In Phase I, Fraunhofer conducted three user research studies and found preferences for aesthetically pleasing, easy to understand feedback that is accessible through multiple media and offered free of charge. The deployment of HEDs in 150 households planned for Phase II encountered major recruitment and HED field deployment problems. In light of these challenges, the team is pursuing a modified study investigating the energy savings of a web portal versus alert-based energy feedback instead of a physical HED.
... Education & Events Advocacy For Patients About ACOG Multiple Pregnancy Home For Patients Search FAQs Multiple Pregnancy Page ... Multiple Pregnancy FAQ188, July 2015 PDF Format Multiple Pregnancy Pregnancy How does multiple pregnancy occur? What are ...
Grunwald, I.Q.; Kuehn, A.L.; Backens, M.; Papanagiotou, P. [Universitaet des Saarlandes, Abteilung fuer Diagnostische und Interventionelle Neuroradiologie, Radiologische Klinik, Homburg/Saar (Germany); Shariat, K. [Universitaet des Saarlandes, Klinik fuer Neurochirurgie, Homburg/Saar (Germany); Kostopoulos, P. [Universitaet des Saarlandes, Klinik fuer Neurologie, Homburg/Saar (Germany)
Multiple sclerosis is the most common chronic inflammatory disease of myelin with interspersed lesions in the white matter of the central nervous system. Magnetic resonance imaging (MRI) plays a key role in the diagnosis and monitoring of white matter diseases. This article focuses on key findings in multiple sclerosis as detected by MRI. (orig.) [German] Die Multiple Sklerose (MS) ist die haeufigste chronisch-entzuendliche Erkrankung des Myelins mit eingesprengten Laesionen im Bereich der weissen Substanz des zentralen Nervensystems. Die Magnetresonanztomographie (MRT) hat bei der Diagnosestellung und Verlaufskontrolle eine Schluesselrolle. Dieser Artikel befasst sich mit Hauptcharakteristika der MR-Bildbebung. (orig.)
Miake-Lye, Isomi M; Chuang, Emmeline; Rodriguez, Hector P; Kominski, Gerald F; Yano, Elizabeth M; Shortell, Stephen M
Theories, models, and frameworks used by implementation science, including Diffusion of Innovations, tend to focus on the adoption of one innovation, when often organizations may be facing multiple simultaneous adoption decisions. For instance, despite evidence that care management practices (CMPs) are helpful in managing chronic illness, there is still uneven adoption by physician organizations. This exploratory paper leverages this natural variation in uptake to describe inter-organizational patterns in adoption of CMPs and to better understand how adoption choices may be related to one another. We assessed a cross section of national survey data from physician organizations reporting on the use of 20 CMPs (5 each for asthma, congestive heart failure, depression, and diabetes). Item response theory was used to explore patterns in adoption, first considering all 20 CMPs together and then by subsets according to disease focus or CMP type (e.g., registries, patient reminders). Mokken scale analysis explored whether adoption choices were linked by disease focus or CMP type and whether a consistent ordering of adoption choices was present. The Mokken scale for all 20 CMPs demonstrated medium scalability (H = 0.43), but no consistent ordering. Scales for subsets of CMPs sharing a disease focus had medium scalability (0.4 0.5). Scales for CMP type consistently ranked diabetes CMPs as most adoptable and depression CMPs as least adoptable. Within disease focus scales, patient reminders were ranked as the most adoptable CMP, while clinician feedback and patient education were ranked the least adoptable. Patterns of adoption indicate that innovation characteristics may influence adoption. CMP dissemination efforts may be strengthened by encouraging traditionally non-adopting organizations to focus on more adoptable practices first and then describing a pathway for the adoption of subsequent CMPs. Clarifying why certain CMPs are "less adoptable" may also provide
... Adoption Day by completing a foster care adoption and embracing a new member of their family. Driven by... eliminate discriminatory barriers that would separate foster children from a loving family. Adoptive... knowing the love and protection of a permanent family. During National Adoption Month, we give voice to...
Subhrendu K. Pattanayak; D. Evan Mercer; Erin Sills; Jui-Chen Yang
In light of the large number of empirical studies of agroforestry adoption published during the last decade, we believe it is time to take stock and identify general determinants of agroforestry adoption. In reviewing 120 articles on adoption of agricultural and forestry technology by small holders, we find five categories of factors that explain technology adoption...
... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Adoption rule. 341.6... SUBJECT TO SECTION 6 OF THE INTERSTATE COMMERCE ACT § 341.6 Adoption rule. (a) Change in name of carrier... such occurrence. The filing of adoption notices and adoption supplements requires no notice period. (c...
Pérouse de Montclos, M-O
Child psychiatry consultations specialised in filiation and international adoption help adopted children with psychological troubles and their adoptive parents. Regardless to this experience and to recent issues in the fields of attachment and narrativity, psychotraumatism and transcultural, some psychological risk factors for internationnally adopted children are described, requiring specialised psychological help. Copyright © 2011. Published by Elsevier SAS.
Notes that adoption agencies have developed few specific policies on the issue of lesbian and gay adoption. Provides an overview of key considerations about homosexual adopters, including beliefs and values of agency professionals, the legal and social ramifications of adoption into a relationship not based on marriage, and possible consequences…
Sergio Rodrigo Martinez
Full Text Available The legislature, with the enactment of the Statute of Children and Adolescents, now provides the named posthumous adoption, allowing the death of the adopter, in the course of the procedure does not generate the extinction pleaded adoption. Has the purpose to show that, notwithstanding the absence of such law, the construction of new adopters and adopted by families are recognized, since permeated the socially demonstrated affection, even in passing the death of the person occurs before you have to start legal formalization of the adoption petition, thus characterizing the figure of posthumous adoption without prior judicial manifestation.
Sodjinou, Epiphane; Henningsen, Arne
Community-based management (CBM) of village poultry aims to foster development and reduce poverty in Benin by disseminating five technologies for improving village poultry farming. We develop a theoretical model to analyze multiple technology adoption decisions that takes into account...... the interrelations between the technologies. Estimates from multivariate probit models indicate significant interrelations between the five adoption decisions. We show how the estimation results, and particularly the different types of marginal effects, can be utilized to deeply analyze the interrelations between...... adoption decisions. CBM successfully promoted the adoption of various technologies. Some adoption decisions indicate farmers’ general openness towards new technologies....
Cheung, Viola; Weitzman, Carol; Albers Prock, Lisa; Augustyn, Marilyn
Steven is an 11-year-old boy who was adopted from an orphanage in Eastern Europe 8 years ago, when he was 3 years old along with his biological sister who is 1 year older. You have cared for him in your practice since that time seeing them annually for well child care. His mother reports that the first 2 years after adoption were very difficult, and Steven has never really bonded with her or her husband. Currently, he is reported to steal possessions of family members and instigate arguments with his older sister and act defiantly. The parents have put locks on their bedroom door due to fears of violence, primarily by Steven's older sister. Steven's mother reports that she and her husband no longer attempt to "parent" the children and provide minimal supervision to avoid conflict. In school, Steven is reported to have symptoms of inattention and hyperactivity that improved with treatment with stimulant medication and some learning challenges, but otherwise he is described as a lovely boy who has good relationships with his teachers.They present to urgent care clinic when mom stated "We have had enough." That day both children were caught taking $10 from the mother's wallet. On further discussion, it was discovered that they had done this several times over the last month to buy ice cream for neighborhood friends to "welcome them" to the neighborhood. Steven's mother presents today stating that the family has exhausted therapy services and are experiencing financial hardship secondary to investing time and money into behavioral and psychiatric services for Steven and his sister. They want to dissolve the adoption and have the children removed from their home. They seek guidance on how to do this. What would be your initial approach with the parents?
Rodolfo Reinaldo Hermes Petter
Full Text Available This study aimed to identify factors categorical adoption of innovation in three main groups: in products, processes and administrative procedures in a group of micro and small enterprises in the furniture sector, located in the middle western state of Santa Catarina. In particular, the study sought to compare the data of a survey conducted by SEBRAE (2009 observed the same factors present innovation in micro and small businesses scattered throughout the Brazilian territory, in order to compare the national stage for the adoption of innovation in relation the scenario presented by the companies studied in this research. Data collection took place by means of a questionnaire consisting of multiple choice closed questions related to the three aforementioned groups of innovation, which was answered by managers of the constituent companies of the group studied. As a result of this research, it was found that the adoption of innovation in product development is the most important aspect in the surveyed companies. It was also found that they seek to adopt the innovation with the objective of entering new markets. However, the main difficulty in adopting innovation were identified lack of skilled labor, shortage and / or lack of access to technology and financial difficulties. Compared to general adoption of innovation by micro and small enterprises studied by SEBRAE (2009, the studied firms have a tendency to develop in the same direction.
Recent discussions of embryo adoption have sought to make sense of the teaching of the Congregation for the Doctrine of the Faith (CDF) document Dignitas personae which appeared to provide a negative judgment on such a practice. This article aims to provide a personalist account of the process of fertilization and implantation that might serve as the basis for the negative judgment of the CDF document. In doing so, it relies upon the idea that a person, including an embryo, is not to be considered in isolation, but always in relation to God and to others. This approach extends the substantialist conceptualizations commonly employed in discussions of this issue. More generally, the article seeks to highlight the value of a personalist re-framing for an understanding of the moral questions surrounding the beginning of life. Lay summary: This article seeks to make sense of what appears to be a clear-cut rejection, set out in the Congregation for the Doctrine of the Faith (CDF) document Dignitas personae, of the proposal for women to “adopt” surplus frozen embryos. It draws upon more recently developed modes of philosophical/theological reasoning to argue that, in human procreation, both fertilization and implantation represent constitutive dimensions of divine creative activity and so must be protected from manipulative technological intervention. Since embryo adoption requires this kind of technology, it makes sense for the Church document not to approve it. PMID:25698841
Information on adoption must be given to couples who seek treatment for medically-assisted procreation. But is adoption a real alternative? What are the chances for a couple who consults to see its desire for adoption be achieved according to its own situation, the characteristics of the child he wants, and the general situation of adoption? Can adoption, just like assisted procreation, often described by the couples as a "obstacle course", go parallel? Or should one try adoption once assisted reproduction failed? Is the couple willing to suffer the social and legal control of adoption after having supported the medical control of the ART? In all cases, the reality is that two out of three couples engaged in assisted reproduction will have a child whereas scarcely more than one candidate to adoption will be offered to adopt a child after three or four-years procedure. Copyright © 2010 Elsevier Masson SAS. All rights reserved.
Kim, Katherine K; Rudin, Robert S; Wilson, Machelle D
National and state initiatives to spur adoption of electronic health records (EHRs) and health information exchange (HIE) among providers in rural and underserved communities have been in place for 15 years. Our goal was to systematically assess the impact of these initiatives by quantifying the level of adoption and key factors associated with adoption among community health centers in California. Cross-sectional statewide survey. We conducted a telephone survey of all California primary care community health centers (CHCs) from August to September 2013. Multiple logistic regressions were fit to test for associations between various practice characteristics and adoption of EHRs, meaningful use-certified EHRs, and HIE. For the multivariable model, we included those variables which were significant at the P = .10 level in the univariate tests. We received responses from 194 CHCs (73.5% response rate). Adoption of any EHRs (80.3%) and meaningful use-certified EHRs (94.6% of those with an EHR) was very high. Adoption of HIE is substantial (48.7%) and took place within a few years (mean = 2.61 years; SD = 2.01). More than half (54.7%) of CHCs are able to receive data into the EHR indicating some level of interoperability. Patient engagement capacity is moderate, with 21.6% offering a PHR, and 55.2% electronic visit summaries. Rural location and belonging to a multi-site clinic organization both increase the odds of adoption of EHRs, HIE, and electronic visit summary, with the odds ratio ranging from 0.63 to 3.28 (all P values adoption of health information technology (IT) in rural areas may be the result of both federal and state investments. As CHCs lack access to capital for investments, continued support of technology infrastructure may be needed for them to further leverage health IT to improve healthcare.
Griffith, Richard; Tengnah, Cassam
The Government wants to see a large rise in the use of adoption as a means of giving children a secure, loving and permanent home. Guidance coming into effect from April calls for a more pragmatic approach to adoption placements, and calls for the active promotion of the adoption process by health and social care professionals. District nurses will encounter people interested in becoming prospective adopters, but who are unsure if their background or lifestyle makes them eligible. It is essential that district nurses have a working understanding of the guidance and provisions of the Adoption and Children Act 2002 to confidently advise others about adoption and clarify any issues raised.
This paper presents a duopoly model of e-business technology adoption. A leader and a follower benefit from a new e-business technology with uncertain quality depending on its innovation and adoption cost and both firmsâ€™ adoption timing. When innovation and adoption require large set-up costs, the leader favors quick adoption by the follower. The follower prefers either late or no adoption. This is due to a delayed first-mover benefit which stems from an innovatorsâ€™ capability to impose a...
Good, Gretchen A.
This systematic literature review is an exploration of issues for adoptive families throughout the adoption process and into the various phases of the life of the adoptive family. Although there has been much recent research related to adoption, in general, very little adoption literature addresses the often unspoken needs of families who want to…
Staykova, Kalina Stefanova; Damsgaard, Jan
Numerous mobile payment solutions, which rely on new disruptive technologies, have been launched on the payment market in recent years. But despite the growing number of mobile payment apps, very few solutions have turned to be successful as the majority of them fail to gain a critical mass...... of users. In this paper, we investigate successful platform adoption strategies by using the Reach and Range Framework for Multi-Sided Platforms as a strategic tool to which mobile payment providers can adhere in order to tackle some of the main challenges they face throughout the evolution...... of their platforms. The analysis indicates that successful mobile payment solutions tend to be launched as one-sided platforms and then gradually be expanded into being two-sided. Our study showcases that the success of mobile payment platforms lies with the ability of the platform to balance the reach (number...
... Español Text Size Email Print Share Inducing Lactation: Breastfeeding for Adoptive Moms Page Content Article Body A growing number of adoptive mothers are interested in breastfeeding their babies through induced lactation. Prescription Medications No ...
... small. National Adoption Day is a day of hope and happiness when courthouses finalize the adoptions of... permanent and caring family, as well as to support the families who care for them. IN WITNESS WHEREOF, I...
The objective of the Economic Impacts of Electric Vehicle Adoption research project was to : examine the predicted levels of electric vehicle (EV) adoption, to analyze the life cycle costs of : EVs compared to internal combustion engine vehicles and ...
Raghavan, Vijay V; Chinta, Ravi; Zhirkin, Nikita
While adoption rates for electronic health records (EHRs) have improved, the reasons for significant geographical differences in EHR adoption within the USA have remained unclear. To understand the reasons for these variations across states, we have compiled from secondary sources a profile of different states within the USA, based on macroeconomic and macro health-environment factors. Regression analyses were performed using these indicator factors on EHR adoption. The results showed that internet usage and literacy are significantly associated with certain measures of EHR adoption. Income level was not significantly associated with EHR adoption. Per capita patient days (a proxy for healthcare need intensity within a state) is negatively correlated with EHR adoption rate. Health insurance coverage is positively correlated with EHR adoption rate. Older physicians (>60 years) tend to adopt EHR systems less than their younger counterparts. These findings have policy implications on formulating regionally focused incentive programs.
Sharkey, Paulette Bochnig
Annotated bibliography covers children's and adolescent fiction and nonfiction on the topic of adoption published since 1988. Brief content descriptions and indications of age appropriateness are given for 35 books. Books dealing with transracial adoption are starred. (KRN)
Hockey, Athel; Bain, Jill
An approach combining social worker and geneticist expertise in adoption is outlined in the study involving 180 families. Genetic counseling has shown to be an essential safeguard to the preservation of the adoptive family unit. (Author/SW)
fungicides, pruning and fermentation were cocoa technologies adopted by farmers. The significant factors influencing adoption of cocoa technologies included age, educational level, household size, no of farm family assisting on the farm, ...
Ingle, William Kyle; Petroff, Ruth Ann
The concentration of broad-based merit aid adoption in the southeastern United States has been well noted in the literature. However, there are states that have adopted broad-based merit aid programs outside of the Southeast. Guided by multiple theoretical frameworks, including innovation diffusion theory (e.g., Gray, 1973, 1994; Rogers, 2003),…
Bogataj, Kristina; Pucihar, Andreja; Sudzina, Frantisek
The paper presents a proposed research framework for identification of business model elements impacting Cloud Computing Adoption. We provide a definition of main Cloud Computing characteristics, discuss previous findings on factors impacting Cloud Computing Adoption, and investigate technology...... adoption theories, such as Diffusion of Innovations, Technology Acceptance Model, Unified Theory of Acceptance and Use of Technology. Further on, at research model for identification of Cloud Computing Adoption factors from a business model perspective is presented. The following business model building...
... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Adoption notice. 221.160 Section 221.160... REGULATIONS TARIFFS Adoption Publications Required To Show Change in Carrier's Name or Transfer of Operating Control § 221.160 Adoption notice. (a) When the name of a carrier is changed or when its operating control...
... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Adoption. 1506.3 Section 1506.3 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY OTHER REQUIREMENTS OF NEPA § 1506.3 Adoption. (a) An agency may adopt a Federal draft or final environmental impact statement or portion thereof...
... 25 Indians 1 2010-04-01 2010-04-01 false Adoption. 75.18 Section 75.18 Indians BUREAU OF INDIAN... OF CHEROKEE INDIANS, NORTH CAROLINA § 75.18 Adoption. The Tribal Council of the Eastern Band of Cherokee Indians shall be empowered to enact ordinances governing the adoption of new members. [39 FR 43391...
... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Adoption. 230.21 Section 230.21 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE PROCEDURES FOR IMPLEMENTING NEPA § 230.21 Adoption. See 40 CFR 1506.3. A district commander will normally adopt...
... 47 Telecommunication 3 2010-10-01 2010-10-01 false Adoption notice. 61.171 Section 61.171 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) TARIFFS Adoption of Tariffs and Other Documents of Predecessor Carriers § 61.171 Adoption notice. When a carrier's...
Farrington, Jay A.; And Others
This paper presents three case studies of innovation, based on interviews with six adoption agents. Key episodes and incidents which illustrate important principles are drawn from the experiences of these adoption agents. The case studies offer examples of both success and failure--by both internal and external adoption agents. They also emphasize…
Hobaiter, Catherine; Schel, Anne Marijke; Langergraber, Kevin; Zuberbühler, Klaus
The adoption of unrelated orphaned infants is something chimpanzees and humans have in common. Providing parental care has fitness implications for both the adopter and orphan, and cases of adoption have thus been cited as evidence for a shared origin of an altruistic behaviour. We provide new data
Davidson, Jeanette R.; Davidson, Tim
Provides help for professionals working with families completing transracial adoptions, examining how to help white parents understand white privilege and its impact on their children and their transracial families. Highlights white parents who are adopting black or biracial children, discussing the controversy over transracial adoption, adoption…
Howard, Alicia; And Others
How does a cross section of the black community feel about white parents adopting black children? This study suggests that the majority of blacks do not support the militant position against transracial adoption and, in fact, favor such adoption when the alternative is institutionalization. (Author)
Laws regulating adoption are varied and complex in countries that offer children for international adoption (IA), while United States Immigration laws pose additional obstacles to Americans wishing to adopt foreign-born children. Declarations by the United Nations and the development of a convention on IA by the Hague Conference offer some hope…
Pryor, Christin; Pettinelli, J. Douglas
The international adoption entrance story is an unexplored topic in the adoption literature. The stories that families tell of beginning life with their new children has important implications for the development of an autobiographical narrative of an adopted child. A coherent autobiographical narrative is vital for healthy childhood development.…
van der Sijde, P.C.; de Boer, S.J.; McGowan, P.C.; Korteweg, B.
This paper explores technology adoption based on the ‘technology – organisation – environment’ framework to study radio frequency identification (RFID) adoption in South African industries. It operationalises the framework using innovation-adoption theory, ‘organisational capitals’, and ‘societal
Full Text Available The present study was undertaken to identify factors that influences biosecurity adoption on laying hen farmers in Sidrap district, South Sulawesi. This district was choosen because beside it was famous as the center of laying hen farms, it was also as one of districts in South Sulawesi which suffered from Avian influenza outbreak. Total samples were 60 respondents. The samples were choosen through stratified random sampling from two subdistricts which had the most populous of layer smallholders, namely Baranti and Maritengngae. Data were obtained through observations and interviews using a questionnaire. Data were analyzed using a score based on biosecurity status. Biosecurity status was obtained based on the adoption of biosecurity measures which consisted of 9 stages: farm inputs, traffic onto farms, distance from sources of pathogens to shed, exposure of farm, biosecurity at farm boundary, biosecurity between farm boundary and shed, biosecurity at the shed door, traffic into the shed and susceptibility of the flock. Multiple regression model was employed to analyze the data. The study revealed that the adoption biosecurity were associated with gender, age, education, farming experience, farm-income, family size and social capital. These variables contributed 20% variation in biosecurity adoption of laying hen farms. However, only farm income, family size and social capital were the major factors influencing to the adoption of biosecurity (P<0.05.
Wang, Lui; Izygon, Michel; Okron, Shira; Garner, Larry; Wagner, Howard
This paper describes the authors' experience in adopting Model Based System Engineering (MBSE) at the NASA/Johnson Space Center (JSC). Since 2009, NASA/JSC has been applying MBSE using the Systems Modeling Language (SysML) to a number of advanced projects. Models integrate views of the system from multiple perspectives, capturing the system design information for multiple stakeholders. This method has allowed engineers to better control changes, improve traceability from requirements to design and manage the numerous interactions between components. As the project progresses, the models become the official source of information and used by multiple stakeholders. Three major types of challenges that hamper the adoption of the MBSE technology are described. These challenges are addressed by a multipronged approach that includes educating the main stakeholders, implementing an organizational infrastructure that supports the adoption effort, defining a set of modeling guidelines to help engineers in their modeling effort, providing a toolset that support the generation of valuable products, and providing a library of reusable models. JSC project case studies are presented to illustrate how the proposed approach has been successfully applied.
McGuinness, Teena M; Robinson, Cheryl Broadus
American families will continue to adopt children from foreign countries; the desire to have a child transcends national boundaries. Sadly, not all adoptions have happy outcomes. A recent and well-reported incident involved an American mother, who, exasperated with her adopted son's severe behavioral problems, returned him to Russia, alone, on an aircraft. Other tragic reports involve internationally adopted children who have died at the hands of their American parents. This article provides an overview of the consequences of institutionalization as a risk factor for behavioral health of children; implications for nursing care of adoptive families follow. Copyright 2011, SLACK Incorporated.
Bennett, Linda Rae
When combined, primary and secondary infertility affects up to 21 percent of Indonesian couples. Based on ethnographic fieldwork with married heterosexual couples, I explore how intra-family adoption represents a culturally and religiously acceptable pathway to family formation for couples without access to assisted reproductive technologies. I examine how kinship is central to the negotiation of adoption, and to maintaining ethnic and religious continuity within adoptive families. I reveal how adoption can enable infertile women and birth mothers to achieve or escape the dominant expectations of heteronormativity, and discuss intra-family adoption by infertile couples in relation to reproductive stratification and leveling.
Adoption holds particular interest for attachment researchers. Although children adopted as babies experience almost continuous care by their adoptive parents, older placed children experience at least one major change of caregiver when they join their adoptive family. Moreover, in the majority of cases, older placed children have generally suffered a pre-adoption history of abuse, neglect and/or rejection. It is now being recognized that older placed children's attachment histories and internal working models (IWMs) established in relationship with their initial carers remain active in relationship with their new carers. Transactional models have helped both researchers and practitioners to understand the dynamics of parent-child relationships in cases where insecure children with histories of neglect, abuse and rejection find themselves in new caregiving environments. The present study examines the childhood experiences of adult adopted people and their current levels of contact with their adoptive mothers, and in cases where people had searched for and found a birth relative, current levels of contact with their birth mother. Although no information was collected on the adopted adult's pre-placement history, age at placement was used as a proxy measure to examine whether older placed children reported different adoption experiences and what their current levels of contact were with their adoptive and birth mothers. The findings show that age at placement was associated with adopted people's reported experiences of being adopted and current rates of contact with their adoptive and birth mothers, with those placed at older ages most likely to report that they (1) did not feel they belonged in their adoptive families while growing up, (2) did not feel loved by their adoptive mother, (3) were least likely to remain in high-frequency contact with their adoptive mother, and (4) were least likely to remain in high-frequency contact with their birth mother. An
LaMarche, J.; Cheney, K.; Akers, C.; Roth, K.; Sachs, O.
The focus of this project was to investigate the factors influencing consumer adoption of Home Energy Displays (HEDs) and to evaluate electricity consumption in households with basic HEDs versus enhanced feedback methods - web portals or alerts. We hypothesized that providing flexible and relatable information to users, in addition to a basic HED, would make feedback more effective and achieve persistent energy savings. In Phase I, we conducted three user research studies and found preferences for aesthetically pleasing, easy to understand feedback that is accessible through multiple media and offered free of charge. The deployment of HEDs in 150 households planned for Phase II encountered major recruitment and HED field deployment problems. First, after extensive outreach campaigns to apartment complexes with 760 units, only 8% of building's tenants elected to receive a free HED in their homes as part of the field study. Second, the HED used, a leading market model, had a spectrum of problems, including gateway miscommunications, failure to post to a data-hosting third party, and display malfunctions. In light of these challenges, we are pursuing a modified study investigating the energy savings of a web portal versus alert-based energy feedback instead of a physical HED.
This presentation describes the development of attachment between adopted children and their adoptive parents with a focus on the particular issues seen in international adoptions. The questions of settling in, trauma in the country of origin, and the motivations of the adoptive parents will be discussed. Diagnosis and various psychopathological manifestations will be examined, as will outpatient and inpatient modes of therapy. The treatment of children of various ages will be covered along with the necessity for intensive counseling and psychotherapy for the adoptive parents. This will enable the parents to work through early trauma, which will give them and their adopted child the basis for developing healthy attachment patterns. This in turn will enable the child to mature and integrate into society. Possibilities of prevention are discussed. Many of the approaches discussed here regarding attachment and adoption may be applied to foster children and their foster parents.
... Staying Safe Videos for Educators Search English Español Parenting Multiples KidsHealth / For Parents / Parenting Multiples What's in ... your ability to take care of your babies. Parenting Issues With Multiples It may be difficult to ...
The idea that policy diffusion can occur via two different mechanisms has gained attention in the realm of international accounting since the European Union’s adoption of International Financial Reporting Standards (IFRSs) in 2005. Proponents of classical economic approaches to policy adoption argue that countries adopting IFRS are motivated solely by the economic consequences of the standards from which they anticipate an improvement in information quality. Neo-institutional scholars argue, ...
Siti Aisyah Salim
Full Text Available The advent of cloud technology involving low subscription overheads cost has provided small and medium-sized enterprises (SMEs with the opportunity to adopt new cloud-based corporate-wide systems (i.e., cloud ERP. This technology, operating through subscription-based services, has now provided SMEs with a complete range of IT applications that were once restricted to larger organisations. As anecdotal evidences suggest, SMEs are increasingly adopting cloud-based ERP software. The selection of an ERP is a complex process involving multiple stages and stakeholders, suggesting the importance of closer examination of cloud ERP adoption in SMEs. Yet, prior studies have predominantly treated technology adoption as a single activity and largely ignored the issue of ERP adoption in SMEs. Understanding of the process nature of the adoption and the factors that are important in each stage of the adoption potentially may result in guiding SMEs to make well-informed decisions throughout the ERP selection process. Thus, our study proposes that the adoption of cloud ERP should be examined as a multi-stage process. Using the Theory of Planned Behaviour (TPB and Ettlie’s adoption stages, as well as employing data gathered from 162 owners of SMEs, our findings show that the factors that influence the intention to adopt cloud ERP vary significantly across adoptive stages.
Argys, Laura; Duncan, Brian
Every year, a large number of children in the United States enter the foster care system. Many of them are eventually reunited with their biological parents or quickly adopted. A significant number, however, face long-term foster care, and some of these children are eventually adopted by their foster parents. The decision by foster parents to adopt their foster child carries significant economic consequences, including for feiting foster care payments while also assuming responsibility for medical, legal, and educational expenses, to name a few. Since 1980, U.S. states have begun to offer adoption subsidies to offset some of these expenses, significantly lowering the cost of adopting a child who is in the foster care system. This article presents empirical evidence of the role that these economic incentives play in foster parents' decision of when, or if, to adopt their foster child. We find that adoption subsidies increase adoptions through two distinct price mechanisms: by lowering the absolute cost of adoption, and by lowering the relative cost of adoption versus long-term foster care.
Full Text Available This article addresses a contemporary issue for the Republic of Moldova concerning psychological implications of the adoption process for prospective adopters. This demand is due to the fact that the majority of couples or people passing through the decision making adoption process are facing a number of conlicting emotions and spiritual states. Thereby, is signiicant to understand the adoption multidimensionality of social and intrapersonal components. Adoptive parents can feel themselves as victims of „the process”. For them, the assessment of living conditions, the assessment of moral and social guarantees, inclusion or exclusion as eligible adoptive parents, represent a procedure part, which generates frustrations and anxieties. Some of them, often suffer from lack of supporting and understanding, as family members point of view, friends and known people. Also, in this context, parents may face some frustrations related to the matching procedure harmonisation with long cogitation process of the child.
Full Text Available This article addresses a contemporary issue for the Republic of Moldova concerning psychological implications of the adoption process for prospective adopters. This demand is due to the fact that the majority of couples or people passing through the decision making adoption process are facing a number of conflicting emotions and spiritual states. Thereby, is significant to understand the adoption multidimensionality of social and intrapersonal components. Adoptive parents can feel themselves as victims of „the process”. For them, the assessment of living conditions, the assessment of moral and social guarantees, inclusion or exclusion as eligible adoptive parents, represent a procedure part, which generates frustrations and anxieties. Some of them, often suffer from lack of supporting and understanding, as family members point of view, friends and known people. Also, in this context, parents may face some frustrations related to the matching procedure harmonisation with long cogitation process of the child.
Cascino, Stefano; Gassen, Joachim
The adoption of IFRS by many countries worldwide fuels the expectation that financial accounting might become more comparable across countries. This expectation is opposed to an alternative view that stresses the importance of incentives in shaping accounting information. We provide early evidence on this debate by investigating the effects of mandatory IFRS adoption on the comparability of financial accounting information around the world. Our results suggest that while mandatory adoption of...
Sisson, Gretchen; Ralph, Lauren; Gould, Heather; Foster, Diana Greene
Little is known about how adoption factors into pregnancy decision making, particularly when abortion is unavailable. We used data from the Turnaway Study, a longitudinal study of 956 women seeking abortion, including 231 women denied abortions owing to gestational limits. Through semiannual quantitative interviews, we assessed the frequency with which women denied abortion consider and choose adoption, and, among adoption participants, decision satisfaction. We compared differences in the demographic profiles of parenting and adoption participants using mixed effects regression models. We conducted in-depth interviews with 31 women who received or were denied wanted abortions, including 2 adoption participants, focused on understanding pregnancy decision making and feelings about their choice. Interviews were coded using inductive and deductive methods. Most women who received abortions were aware of but uninterested in adoption. A minority of women denied abortions (n = 231; 14%) were considering adoption at 1 week after denial. Of participants who gave birth (n = 161), most (91%) chose parenting. Parenting participants (n = 146) did not differ from adoption participants (n = 15) on measures of age, race, or poverty status, although adoption participants were somewhat less likely to be employed (20% vs. 43%; p = .1), and somewhat more likely to have completed high school (87% vs. 74%; p = .08). Although satisfaction with their decision was high among adoption participants, in-depth interviews revealed mixed emotions. Among women motivated to avoid parenthood, as evidenced by abortion seeking, adoption is considered or chosen infrequently. Political promotion of adoption as an alternative to abortion is likely not grounded in the reality of women's decision making. Copyright © 2016 Jacobs Institute of Women's Health. Published by Elsevier Inc. All rights reserved.
Why are new financial instruments created? This paper proposes the view that financial development arises as a response to the contractual needs of emerging technologies. Exogenous technological progress generates a demand for new financial instruments in order to share risk or overcome private information, for example. A model of the dynamics of technology adoption and the evolution of financial instruments that support such adoption is presented. Early adoption may be required for financial...
Maria Alipranti; Chrysovalantou Milliou; Emmanuel Petrakis
This paper explores how vertical relations influence the timing of new technology adoption. It shows that both the bargaining power distribution among the vertically related firms and the contract type through which vertical trading is conducted affect crucially the speed of adoption: the downstream firms can adopt later a new technology when the upstream bargaining power increases as well as when wholesale price contracts, instead of two-part tariffs, are employed. Importantly, it shows that...
Cervellati, Matteo; Naghavi, Alireza; Toubal, Farid
We study the role of trade liberalization, democratization and their interaction for technology adoption. A general equilibrium theory with heterogeneous skills predicts a complementarity between trade and political regimes. Openness should accelerate technology adoption if coupled with democratization but may lead to a slow down if these regime changes are imbalanced. We use panel data on technology adoption at the sectoral level for the period 1980-2000 by exploiting within country variatio...
van Effenterre, Aude; Harf, Aurélie; Skandrani, Sandra; Taïeb, Olivier; Moro, Marie Rose
In the context of international adoption, the question is raised of the links which the adoptive parents may or may not maintain with the culture of the child's birth country. The name which the adoptive parents choose reflects this questioning. A study was carried out into this subject with parents and children in order to gain a better understanding of the feelings of belonging, filiation and affiliation in these situations.
Boucekkine, Raouf; Martinez, Blanca
In this paper, we introduce adoption costs in a canonical vintage capital model. Adoption costs take the form of a direct loss in production during a fixed period of time. We explicitly characterize the optimal machine replacement policy as a function of the adoption period. Using an explicit numerical method, we study the dynamics of the model. In particular, we find that while an increase in the adoption costs lowers the long run level of output, it also rises the magnitude of short run flu...
van der Sijde, P.C.; van Reekum, R.; Jeurissen, W; Rosendaal, B.W.
Our focus is on the agenda-setting of a purchasing cooperative aiming to have their members consider the adoption of a new logistics information system based on RFID. Adding "technology trust", we used the UTAUT model to determine the adoption intention of associated book retailers. Using structural
Kline, Susan L; Chatterjee, Karishma; Karel, Amanda I
Given that the public uses the media to learn about adoption as a family form, this study analyzes U.S. television news coverage of adoption between 2001 and 2005 (N = 309 stories), to identify the types of news events covered about adoption. A majority of news stories covered fraud, crime, legal disputes, and negative international adoption cases. Adoptees as defective or unhealthy were depicted more in negative news event stories, birth parents appeared less overall, and adoptive parents were most likely to have healthy depictions in positively oriented adoption experience, big family, and reunion stories. Although three quarters of the stories used primary adoption participants as news sources, one-third of the negative event stories did not contain healthy depictions of adoption participants. The authors discuss ways journalists and researchers might improve adoption news coverage.
van Londen, W Monique; Juffer, Femmie; van Ijzendoorn, Marinus H
To examine infant attachment and developmental functioning shortly after international adoption. At 14 months, infant-mother attachment and mental (MDI) and psychomotor (PDI) development were assessed in 70 internationally adopted children. Mean age at arrival was 5.5 months, mean stay in the adoptive family 8.7 months. Adopted children's MDI and PDI did not deviate from normative scores. Also, their secure-insecure attachment distribution was comparable with that of normative groups. However, more adoptees were disorganized attached (36 vs. 15% in normative groups). Temporary residence in a foster home in the country of origin before adoption was related to higher MDI and PDI, whereas disorganized attachment in the adoptive family was related to lower MDI and PDI scores. The majority of internationally adopted children form secure attachment relationships and function at normative developmental levels shortly after adoption. Residence in a foster family before adoption may partly prevent developmental delays.
Full Text Available The present study was undertaken to identify factors that influences biosecurity adoption on layinghen farmers in Sidrap district, South Sulawesi. This district was choosen because beside it was famousas the center of laying hen farms, it was also as one of districts in South Sulawesi which suffered fromAvian influenza outbreak. Total samples were 60 respondents. The samples were choosen throughstratified random sampling from two subdistricts which had the most populous of layer smallholders,namely Baranti and Maritengngae. Data were obtained through observations and interviews using aquestionnaire. Data were analyzed using a score based on biosecurity status. Biosecurity status wasobtained based on the adoption of biosecurity measures which consisted of 9 stages: farm inputs, trafficonto farms, distance from sources of pathogens to shed, exposure of farm, biosecurity at farm boundary,biosecurity between farm boundary and shed, biosecurity at the shed door, traffic into the shed andsusceptibility of the flock. Multiple regression model was employed to analyze the data. The studyrevealed that the adoption biosecurity were associated with gender, age, education, farming experience,farm-income, family size and social capital. These variables contributed 20% variation in biosecurityadoption of laying hen farms. However, only farm income, family size and social capital were the majorfactors influencing to the adoption of biosecurity (P<0.05.
Siti Hajar Mohd Idris
Full Text Available Studies have shown that low adoption rate among citizens has been hindering the optimization of e-Government services especially in developing countries. Hence, one of the critical measures that has to be undertaken is to identify and overcome possible barriers to further facilitate a higher rate of adoption. A multistage stratified sampling was used in this study to collect data from 1000 respondents, both user and non-user residing in the state of Selangor, Malaysia. This state was chosen as to provide a better understanding of low adoption when issues of basic facilities have been successfully overcome. An exploratory factor analysis was performed to identify latent constructs and seven key factors were identified. A multiple regression model was subsequently used to analyze significant factors in determining the willingness to use e-Government services. The determinants are language barrier, educational level, secure, format, easy to use, enjoyable, reliable, visual appeal and infrastructure. The result shows significant variables that act as barriers to adoption are reliable, enjoyable, easy to use, secure, and language used. The constraints pointed out in the open ended questions mainly focus on the issue of accessibility, ease of use and awareness. Overcoming these obstacles is therefore crucial in order to enhance the usage of e-Government services which consequently will improve the quality of public administration in Malaysia.
Brooker, A.; Gonder, J.; Lopp, S.; Ward, J.
The Automotive Deployment Option Projection Tool (ADOPT) is a light-duty vehicle consumer choice and stock model supported by the U.S. Department of Energy’s Vehicle Technologies Office. It estimates technology improvement impacts on U.S. light-duty vehicles sales, petroleum use, and greenhouse gas emissions. ADOPT uses techniques from the multinomial logit method and the mixed logit method estimate sales. Specifically, it estimates sales based on the weighted value of key attributes including vehicle price, fuel cost, acceleration, range and usable volume. The average importance of several attributes changes nonlinearly across its range and changes with income. For several attributes, a distribution of importance around the average value is used to represent consumer heterogeneity. The majority of existing vehicle makes, models, and trims are included to fully represent the market. The Corporate Average Fuel Economy regulations are enforced. The sales feed into the ADOPT stock model. It captures key aspects for summing petroleum use and greenhouse gas emissions This includes capturing the change in vehicle miles traveled by vehicle age, the creation of new model options based on the success of existing vehicles, new vehicle option introduction rate limits, and survival rates by vehicle age. ADOPT has been extensively validated with historical sales data. It matches in key dimensions including sales by fuel economy, acceleration, price, vehicle size class, and powertrain across multiple years. A graphical user interface provides easy and efficient use. It manages the inputs, simulation, and results.
Sopha, Bertha Maya; Hertwich, Edgar G.; Kloeckner, Christian A.
The aim of the present paper is to understand the differences between adopters and non-adopters of wood pellet heating in Norwegian households by comparing the two groups with regard to key points of adoption. A mail survey of 669 adopters and 291 non-adopters of wood pellet heating was conducted in 2008. Results indicate that there are significant differences between groups with respect to socio-demographic factors, decision-related factors, heating systems adopted and reasons for shifting heating systems. The results also indicate that the adopter group shows characteristics of early adopters, whereas the non-adopter group has characteristics of late adopters. The results for levels of income and education contradict what would be predicted from theory, however. Both groups show no significant difference with respect to values, but the perception of which heating system is the most environmentally friendly differs significantly. The top three reasons cited by the adopter group for installing wood pellet heating are getting an environmentally friendly heating system, low operation costs and an anticipated increase in electricity prices. According to the non-adopter group, the main barriers to adoption are high installation costs, followed by the difficulties of refitting the house for wood pellet heating. A higher subsidy (i.e., an average of 64% of the total installation cost) rather than the current subsidy of up to 20% was required by the non-adopter group to switch to wood pellet heating. (author)
Diamond, Gary W; Senecky, Yehuda; Schurr, Daniel; Zuckerman, Jay; Inbar, Dov; Eidelman, Arthur; Cohen, Herbert J
The number of child adoptions from abroad is increasing, but the adverse living conditions of these children prior to the adoption raise questions on their medical and neurodevelopmental status, particularly since there are no guidelines for pre- or post-adoption medical evaluation. To describe the condition of a cohort of young children who were candidates for adoption in East European orphanages and foster homes, and to determine those attributes associated with a family's decision to adopt or refuse a particular child. Eighty-two young children, median age 11 months, were evaluated by Israeli pediatricians in Eastern Europe between 3 weeks and 6 months prior to their adoption. The evaluation consisted of comprehensive medical and neurodevelopmental testing on site using a battery of standardized assessment tools, and observation of free play and social interactive behaviors recorded on videotape. Laboratory tests included complete blood count, chemistries, serology screening, and metabolic and genetic testing. The children were growth-retarded. Medical problems were classified as resolved (pneumonia and diarrhea) in 32.8%; or ongoing, such as hepatitis B and C, failure to thrive, organomegaly, and visual and hearing disorders, in 14.8%. Neuromotor status was grossly abnormal in 13.4%. Twenty-two percent of the children were rejected for adoption by families in Israel. Factors associated with the adoption decision were performance skills on developmental testing (P = 0.0001), present medical status (P = 0.002), and weight (P = 0.016). Pre-placement comprehensive screening of children eligible for foreign adoption, which includes developmental screening, helps to identify a wide variety of strengths and impairments in a child's background before the adoption procedure is finalized. A family's decision to adopt or not was associated with the child's performance on Bayley Scales, weight, and current medical status, but not with language delays, serious past medical
Lopez, L.; Costal, D.; Ayala, C.P.; Haaland, K.; Glott, R.
Increasing adoption of Open Source Software (OSS) in information system engineering has led to the emergence of different OSS business strategies that affect and shape organizations’ business models. In this context, organizational modeling needs to reconcile efficiently OSS adoption strategies with
Lee, Jaegoo; Crolley-Simic, Josie; Vonk, M. Elizabeth
This study explored the attitudes of MSW students ("N"?=?147) toward transracial adoption and included an investigation of the students' personal experiences that may affect their attitudes. Statistical analyses revealed that although the majority of students supported the practice of transracial adoption, a number of students gave…
Van Horne, Sam; Murniati, Cecilia Titiek
Although post-secondary educational institutions are incorporating more active learning classrooms (ALCs) that support collaborative learning, researchers have less often examined the cultural obstacles to adoption of those environments. In this qualitative research study, we adopted the conceptual framework of activity theory to examine the…
Variety Characteristics And Cassava Adoption Among Rural Households In Imo State. DO Onu, DO Ohajianya. Abstract. This study investigated the factors contributing to low levels of adoption of improved cassava varieties in Imo State. A sample of 120 respondents was randomly selected for the study and interviewed ...
Over the last several years, state and local governments have increased the privatization of a range of services that historically have been provided by government agencies, including adoption services. This issue brief of the Child Welfare League of America provides adoption professionals with information on the privatization of adoption…
This article involves a qualitative study of factors impacting the adoption of ICT solutions in the Danish facility management supply chain. The results show that there are a number of drivers and barriers that influence the adoption of ICT solutions in this service sector. These have been groupe...
This paper investigates the question what attributes of countries influence the differential speed at which they adopt new communication technologies. On the basis of empirical data, it concludes that besides GNP per capita, cultural variables predict the speed of technology adoption. In particular,
The author strongly argues for transracial adoption considering it as an effective way to eradicate various problems facing black children. She answers various objections raised against transracial adoption. The important issue, the author maintains, is to provide psychological care to many black children who need it badly. (SE)
Courtney, Mark E.
Argues the transracial adoption debate has focused on the impact on children adopted rather than on efforts to improve the lives of children of color. Suggests society focus on conditions that bring the children to the attention of child protection authorities and solve problems in the child welfare system. (Author/SD)
Scarr, Sandra; And Others
Intelligence tests were administered twice to 426 members of 93 transracial adoptive families, once when the adopted children's ages averaged 7 years and again when they averaged 17 years. Correlations suggest that influences on intellectual development in this sample of black and interracial adoptees reared in white families are similar to those…
Singer, Leslie M.; And Others
No differences were found in mother-infant attachment between nonadopted and intraracial adopted subjects or between intraracial and interracial adopted subjects. Suggests that the higher incidence of psychological problems found among adoptees in middle childhood and adolescence cannot be explained in terms of insecure attachment relationships…
include among others: pedestals, armour layers and tree moulds which lead to the destruction of many ... soil management practices adopted by the farmers on the eroded lands as well as the laboratory analyses of the ... observation of the soil management practices adopted by the farmers. In the administration of the.
Findings from the study revealed that the awareness level on cassava production technologies was low (36.9%) and adoption level was also low (21.6%). The study identified 5 important constraints to the adoption of cassava production technologies. These are: inadequate fund, high cost of technologies, inadequate land ...
Nickman, Steven L; Rosenfeld, Alvin A; Fine, Paul; Macintyre, James C; Pilowsky, Daniel J; Howe, Ruth-Arlene; Derdeyn, Andre; Gonzales, Mayu Bonoan; Forsythe, Linda; Sveda, Sally A
To summarize the past 10 years of published research concerning the 2% of American children younger than 18 years old who are adoptees. Review recent literature on developmental influences, placement outcome, psychopathology, and treatment. Adoption carries developmental opportunities and risks. Many adoptees have remarkably good outcomes, but some subgroups have difficulties. Traditional infant, international, and transracial adoptions may complicate adoptees' identity formation. Those placed after infancy may have developmental delays, attachment disturbances, and posttraumatic stress disorder. Useful interventions include preventive counseling to foster attachment, postadoption supports, focused groups for parents and adoptees, and psychotherapy. Variables specific to adoption affect an adopted child's developmental trajectory. Externalizing, internalizing, attachment, and posttraumatic stress disorder symptoms may arise. Child and adolescent psychiatrists can assist both adoptive parents and children.
Lee, Jinhyung; Park, Young-Taek
The objective of this study was to create a new measure for clinical information technology (IT) adoption as a proxy variable of clinical IT use. Healthcare Information and Management Systems Society (HIMSS) data for 2004 were used. The 18 clinical IT applications were analyzed across 3,637 acute care hospitals in the United States. After factor analysis was conducted, the clinical IT adoption score was created and evaluated. Basic clinical IT systems, such as laboratory, order communication/results, pharmacy, radiology, and surgery information systems had different adoption patterns from advanced IT systems, such as cardiology, radio picture archiving, and communication, as well as computerized practitioner order-entry. This clinical IT score varied across hospital characteristics. Different IT applications have different adoption patterns. In creating a measure of IT use among various IT components in hospitals, the characteristics of each type of system should be reflected. Aggregated IT adoption should be used to explain technology acquisition and utilization in hospitals.
Full Text Available Building Information Modeling is modeling technology and associated set of processes to produce, communicate and analyze digital information models for construction life cycle. Although many benefits can gain by the implementation of BIM, the pace adoption of BIM in Malaysia is still slow. There is an abundance of theories and models purporting to describe the drivers and mechanisms of how new technologies are adopted or diffused into a particular section of society or by individuals or stake players. In addition, many acceptance theories, which imply the adoption of new technologies and can be applied in every sector. This paper aims to present a review of the existing literature of BIM adoption and diffusion theory/model/framework in Malaysia. Researcher revealed the list of driven factors of Holistic BIM Adoption. In addition, it will deal with how to work effectively with groups that initially are relatively
Nielsen, Jørn Flohr
it connects the change motors. The analysis questions the assumption that participation always helps in overcoming resistance to change. Participation often leads to tensions and conflicts, especially when multiple motors and different change efforts are operating simultaneously. Practically, this application......This article illustrates how advanced theories of change are useful in understanding the actual adoption of emergent Internet technologies drawing on surveys of Nordic banks. The point of departure is Van de Ven and Poole's identification of four basic types of theories of change: life cycle......, teleological (including planned change), dialectical, and evolutionary theories. These theories are shown to provide a useful framework for examining the adoption and implementation of Internet technology at different stages. Especially, it is shown how participation can be included in the models and how...
Calabrese, Edward J
The historical foundations of cancer risk assessment were based on the discovery of X-ray-induced gene mutations by Hermann J. Muller, its transformation into the linear nonthreshold (LNT) single-hit theory, the recommendation of the model by the US National Academy of Sciences, Biological Effects of Atomic Radiation I, Genetics Panel in 1956, and subsequent widespread adoption by regulatory agencies worldwide. This article summarizes substantial recent historical revelations of this history, which profoundly challenge the standard and widely acceptable history of cancer risk assessment, showing multiple significant scientific errors and incorrect interpretations, mixed with deliberate misrepresentation of the scientific record by leading ideologically motivated radiation geneticists. These novel historical findings demonstrate that the scientific foundations of the LNT single-hit model were seriously flawed and should not have been adopted for cancer risk assessment.
Korff, Lynn Von; Grotevant, Harold D.
The present study examined adoption-related family conversation as a mediator of the association between adoptive parents’ facilitation of contact with birth relatives and adolescent adoptive identity formation. The sample consisted of 184 adoptive families. Data were collected in two waves from adoptive mothers and fathers, and adoptees (M = 15.68 years at adolescence; M = 24.95 years at emerging adulthood) using semistructured interviews and questionnaires. Structural equation models showed a good fit to sample data, and analyses supported the hypothesized mediation model. Contact with birth relatives is associated with more frequent adoption-related family conversation, which in turn is associated with the development of adoptive identity. These results highlight the importance of supporting activities such as contact that lead to adoption-related family conversation. PMID:21517175
Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the ... attacks healthy cells in your body by mistake. Multiple sclerosis affects women more than men. It often begins ...
In ANOVA we are mainly based on inter-treatment comparisons. Another common problems arising in biometric studies (especially in biomedical studies) is that of comparing two groups of patients (treatment and a control group) based on multiple response (called multiple endpoints). In this paper we present the continuos and discrete approaches to multiple endpoints. In the case of continuous multiple endpoints we have common assumption in that the covariance matrices in group ...
Bjørn, Pernille; Hertzum, Morten
Whiteboards are highly important to the work in emergency departments (EDs). As a collaborative technology ED whiteboards are usually placed in the dynamic centre of the ED, and all ED staff will approach the whiteboard regularly to organize their individual yet interdependent work. Currently, di...... this characteristic of heterogeneous artefacts; namely artefactual multiplicity. Artefactual multiplicity identifies not only the multiple functions of heterogeneous artefacts but also the intricate relations between these multiple functionalities....
Multiplication facts are difficult to teach. Therefore many researchers have put a great deal of effort into finding multiplication strategies. Sherin and Fuson (2005) provided a good survey paper on the multiplication strategies research area. Kolpas (2002), Rendtorff (1908), Dabell (2001), Musser (1966) and Markarian (2009) proposed the finger…
The socioeconomic and sanitary conditions in many countries make it necessary to weigh as precisely as possible the uncertainties which might affect the health of internationally adopted children, which is one of the key drivers to adoption decision. Indeed, health troubles are more and more frequent among children proposed by countries, at a time when there are fewer children to be adopted. Hence the institutions and the actors in the field of international adoption are compelled to frequently update their professional practices, so as to cope both with the declining offer for adoptable children and with the increasing pressure from the birth countries of children to make host countries adopt children with high age or with special needs. It also requires from the administrations the will to provide better initial information and to implement the demand for an agreement. Meanwhile, in spite of those growing constraints, adopting families have been more and more risk adverse during the latest decades, this being a common trend in our developed countries.
Staat, Dana D; Klepser, Michael E
International adoptions have become increasingly common in the United States. Children awaiting international adoption and families traveling to adopt these children can be exposed to a variety of infectious diseases. Compared with the United States, foreign countries often have different immunization practices and methods of diagnosing, treating, and monitoring disease. Reporting of medical conditions can also differ from that of the United States. The prevalence of infectious diseases varies from country to country and may or may not be common among adopted children. The transmission of tuberculosis, hepatitis B, and measles from adopted children to family members has been documented. Furthermore, infectious organisms (e.g., intestinal parasites), bacterial pathogens (e.g., Bordetella pertussis and Treponema pallidum), and viruses (e.g., human immunodeficiency virus and hepatitis viruses) may cause clinically significant morbidity and mortality among infected children. Diseases such as severe acute respiratory syndrome or avian influenza have not been reported among international adoptees, but transmission is possible if infection is present. Family members may be infected by others during travel or by their adopted child after returning home. Families preparing to adopt a child from abroad should pay special attention to the infectious diseases they may encounter and to the precautions they should take on returning home.
Quiroz, Pamela Anne
The discursive practices of adoptive parents in two online transnational adoption forums (2006-2008) and observations of five international adoption workshops suggest that what Heather Jacobson described as "culture keeping", the cultural socialization of children that retains a sense of native group identity, is more aptly characterized as…
Beaupre, Adam J.; Reichwald, Reed; Zhou, Xiang; Raleigh, Elizabeth; Lee, Richard M.
Adopted Korean adolescents face the task of grappling with their identity as Koreans and coming to terms with their adoptive status. In order to explore these dual identities, the authors conducted a person-centered study of the identity profiles of 189 adopted Korean American adolescents. Using cluster analytic procedures, the study examined…
Barth, Richard P.
While adoption is a goal for welfare services when children cannot remain at home, adoption should not become a goal unless family reunification cannot occur. Recent initiatives take an oversimplified approach to agency standards, creating misunderstanding of programs. Adoption rates of agencies should be rewarded only after estimating pool of…
Vonk, M. Elizabeth; Angaran, Ruth
This study sought to determine aspects of training provided to transracial adoptive parents by public and private U.S. adoption agencies. Responses to a survey of a random sample of public and private agencies indicated that about half of the agencies that facilitate transracial adoption provide relevant training. Findings pose implications for…
Siegel, Deborah H.
Conducted qualitative study of adoptive parents' (n=21 couples) reactions to recent open adoptions of their infants. Findings indicated overwhelmingly positive feelings about open adoption. Respondents often noted that issue of openness was eclipsed by other concerns: coping with infertility, finding a baby, dealing with personnel, and dealing…
Matthews, John D.; Cramer, Elizabeth P.
Gays and lesbians, both single and coupled, are increasingly turning to adoption to create or expand their families. This manuscript specifically addresses the continuing needs of adoptees and adoptive parents by exploring key issues in the life course of gays and lesbians and their adopted children, and identifying potential parallel development…
Kebebe, E G; Oosting, S J; Baltenweck, I; Duncan, A J
While there is a general consensus that using dairy technologies, such as improved breeds of dairy cows, can substantially increase farm productivity and income, adoption of such technologies has been generally low in developing countries. The underlying reasons for non-adoption of beneficial technologies in the dairy sector are not fully understood. In this study, we characterised adopters and non-adopters of dairy technologies in Ethiopia and Kenya based on farmers' resources ownership in order to identify why many farmers in Ethiopia and Kenya have not adopted improved dairy technologies. As compared to non-adopters, farmers who adopt dairy technology own relatively more farm resources. The result signals that differences in resource endowments could lead to divergent technology adoption scenarios. Results show that a higher proportion of sample smallholders in Kenya have adopted dairy technologies than those in Ethiopia. Except for the use of veterinary services, fewer than 10% of sample farmers in Ethiopia have adopted dairy technologies-less than half the number of adopters in Kenya. The higher level of dairy technology adoption in Kenya can be ascribed partly to the long history of dairy development, including improvements in the value chain for the delivery of inputs, services and fluid milk marketing. Interventions that deal with the constraints related to access to farm resources and input and output markets could facilitate uptake of dairy technology in developing countries.
Moezzi, Mithra [Portland State Univ., Portland, OR (United States); Ingle, Aaron [Portland State Univ., Portland, OR (United States); Lutzenhiser, Loren [Portland State Univ., Portland, OR (United States); Sigrin, Benjamin O. [National Renewable Energy Laboratory (NREL), Golden, CO (United States)
Although U.S. deployment of residential rooftop solar photovoltaic (PV) systems has accelerated in recent years, PV is still installed on less than 1 percent of single-family homes. Most research on household PV adoption focuses on scaling initial markets and modeling predicted growth rather than considering more broadly why adoption occurs. Among the studies that have investigated the characteristics of PV adoption, most collected data from adopters, sometimes with additional non-adopter data, and rarely from people who considered but did not adopt PV. Yet the vast majority of Americans are non-adopters, and they are a diverse group - understanding their ways of evaluating PV adoption is important. Similarly, PV is a unique consumer product, which makes it difficult to apply findings from studies of other technologies to PV. In addition, little research addresses the experience of households after they install PV. This report helps fill some of these gaps in the existing literature. The results inform a more detailed understanding of residential PV adoption, while helping ensure that adoption is sufficiently beneficial to adopters and even non-adopters.
Scholtens, B.; Dam, L.
We analyze the performance of banks that adopted the Equator Principles. The Equator Principles are designed to assure sustainable development in project finance. The social, ethical, and environmental policies of the adopters differ significantly from those of banks that did not adopt the Equator
Rosu Anca Maria
Full Text Available E-banking, or banking via the Internet, is revolutionising the business, having multiple benefits both for the financial institutions and for clients. E-bankers offer better customer service, creating opportunities for customers and providing added value. They treat customers as individuals, making masss customisation possible and creating customer loyalty. E-banking is an opportunity for banks to leverage their strenghts and create a totally new banking experience. The present paper investigates and analyses the adoption and evolution of electronic banking in Romania, and the appropriate strategies for development of online banking services in the Romanian context.
Geist, William H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
This set of slides begins by giving background and a review of neutron counting; three attributes of a verification item are discussed: 240Pueff mass; α, the ratio of (α,n) neutrons to spontaneous fission neutrons; and leakage multiplication. It then takes up neutron detector systems – theory & concepts (coincidence counting, moderation, die-away time); detector systems – some important details (deadtime, corrections); introduction to multiplicity counting; multiplicity electronics and example distributions; singles, doubles, and triples from measured multiplicity distributions; and the point model: multiplicity mathematics.
A. A. Bosov
Full Text Available Purpose. The development of complicated techniques of production and management processes, information systems, computer science, applied objects of systems theory and others requires improvement of mathematical methods, new approaches for researches of application systems. And the variety and diversity of subject systems makes necessary the development of a model that generalizes the classical sets and their development – sets of sets. Multiple objects unlike sets are constructed by multiple structures and represented by the structure and content. The aim of the work is the analysis of multiple structures, generating multiple objects, the further development of operations on these objects in application systems. Methodology. To achieve the objectives of the researches, the structure of multiple objects represents as constructive trio, consisting of media, signatures and axiomatic. Multiple object is determined by the structure and content, as well as represented by hybrid superposition, composed of sets, multi-sets, ordered sets (lists and heterogeneous sets (sequences, corteges. Findings. In this paper we study the properties and characteristics of the components of hybrid multiple objects of complex systems, proposed assessments of their complexity, shown the rules of internal and external operations on objects of implementation. We introduce the relation of arbitrary order over multiple objects, we define the description of functions and display on objects of multiple structures. Originality.In this paper we consider the development of multiple structures, generating multiple objects.Practical value. The transition from the abstract to the subject of multiple structures requires the transformation of the system and multiple objects. Transformation involves three successive stages: specification (binding to the domain, interpretation (multiple sites and particularization (goals. The proposed describe systems approach based on hybrid sets
Saiz, Stephen G.
This paper looks at three parties impacted by adoption: the adoptive parents, the adopted child, and the adoptive family. When working with adoptive parents, counselors should respect the strength of the couple, their commitment to parenthood, and the closeness that may develop from weathering the issue of childlessness. Adoptive parents are…
... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Proof of adoption. 843.404 Section 843... Proof of adoption. (a) An adopted child is— (1) A child adopted by the employee or retiree before the... petition for adoption was filed by the employee or retiree and who is adopted by the current spouse of the...
Roby, Jini L.; White, Holly
There is a growing practice of adoption services on the Internet with varying degrees of regulation, depending on whether it is domestic infant adoption, public foster care adoption, or international adoption. Regulation is particularly lacking in domestic infant adoptions, with Web sites connecting prospective birth and adoptive parents,…
Helwig, Andrew A.; Ruthven, Dorothy H.
Examines adoption issues including family member loss, infertility, transracial adoptions, special-needs adoptions, older child adoption, inherited traits, adoptive family, biological parents, and open adoption. Suggests specific therapeutic interventions including redefinition, use of paradox, family therapy approaches, group therapy, and…
Zamostny, Kathy P.; O'Brien, Karen M.; Baden, Amanda L.; Wiley, Mary O'Leary
This article presents an overview of the practice of adoption to counseling psychologists to promote clinical understanding of the adoption experience and to stimulate research on adoption. The article includes definitions of adoption terminology, important historical and legal developments for adoption, a summary of adoption statistics,…
Full Text Available Green IT has emerged as an important research topic in information systems and in other areas, such as business sustainability management. Some progress has been made in our understandings of green IT in a wide area of research topics, ranging from the green IT definition to the motivation for adopting green IT by organizations. This paper provides a holistic review and explanation of why organizations adopt green IT. Based on an extensive review of extant studies and a broad theoretical foundation, the paper presents a theoretical framework on organizational green IT adoption (OGITA. For researchers, the study provides a comprehensive review of previous green IT adoption studies and a roadmap for future research. For practitioners, the study provides managers and policy makers a systematic analytical framework in guiding their business decisions.
IT is operationally critical and strategic to an enterprise's success. Implementing best professional management practices should be a management imperative. ITIL and COBIT are two of the most widely adopted frameworks for supporting IT governance and management improvement initiatives.
... additional children? Keep in mind: There are no “right” or “wrong” responses to these questions, and you may not know the answers right now . Selecting an Agency or Independent Adoption If ...
Jones, Edmond D.
Transracial adoptions have been encouraged widely as a way to meet the needs of many black children. This practice and the agency philosophy behind it are challenged in the light of today's social realities. (Editor)
Canton, E.J.F.; de Groot, H.L.F.; Nahuis, R.
Employed technologies differ vastly across countries. Within countries many technologies that would obviously improve firms’ efficiency are not adopted. This paper explains these observations by emphasizing that a new technology positively affects workers by lowering prices and increasing their real
... their child's feelings, sensing that he might be hurt at finding out he was adopted. They might ... example, he may understand that he has "two mothers" and "two fathers," but the social customs and ...
Gagnon, Pieter; Sigrin, Ben
NREL has used its dSolar (distributed solar) model to generate low-medium-high estimates of distributed PV adoption in Maine through 2021. This presentation gives a high-level overview of the model and modeling results.
Practitioners can over-estimate the incidence of problems in adopted children and adults because they do not see those who make good psychological and social adjustments. Research into adoption outcomes can be hard to interpret without information about differing pre-adoption histories. Examples are given of research into three types of adoption: domestic infant adoption, adoptions from public care of maltreated children and international adoption of ex-orphanage children. Although negative outcomes are indisputably evident for some, recovery from adversity is more common than many would predict. It is important to recognize that subsequent nurturing in consistent and stimulating environments can build a platform for effective adaptations to challenges in the future. However, a proper understanding of the consequences of adoption has been limited by the fact that follow-up studies have rarely extended beyond adolescence and early adulthood. The British Chinese Adoption Study is a 50 year follow-up of orphanage girls internationally adopted into the United Kingdom, and is given as an example of good outcomes despite early years of adversity. Scores on mental health assessments were equivalent to the non-adopted, age-matched comparison group of UK women. Most of the women were rated as "good functioning" and educational achievements were many times higher than the comparison women. Life-long adverse effects are not inevitable following early adversity. Improved circumstances can promote recovery and good adult adjustment. Practice and research implications are discussed.
Revi Nair; Babu P. George
This paper explores issues and challenges in the adoption of e-learning in hospitality education, with special reference to Singapore. Hospitality being a ‘high-touch’ profession and many hospitality related skills being largely intangible, there has been significant industry resistance in technology adoption. There has been concerns from multiple stakeholder groups as to how effectively can technologies compensate for the loss of social context of traditional hands-on learning. However, in S...
Osorio-Gallego, Carlos; Londoño-Metaute, John; López-Zapata, Esteban
Purpose: The objective of this article is to analyze the factors that influence the adoption of Information and Communication Technologies (ICT) by SMEs in Colombia. Design/methodology: To prove empirically these hypotheses, we administered a questionnaire to a sample of 474 SMEs in Colombia regarding the adoption of ICT and independent variables identified in the literature. Then, we conducted a series of multiple regression models using the data we obtained. Findings: We developed a m...
Stefano Cascino; Joachim Gassen
The mandatory adoption of IFRS by many countries worldwide fuels the expectation that financial accounting information might become more comparable across countries. This expectation is opposed to an alternative view that stresses the importance of incentives in shaping accounting information. We provide early evidence on this debate by investigating the effects of mandatory IFRS adoption on the comparability of financial accounting information around the world. Using two comparability proxie...
This master thesis is an empirical investigation project that has been carried out in cooperation with Trustweaver AB. The purpose is to identify the key factors that influence the adoption of electronic invoicing in Chinese enterprises. A background study on global e-invoicing adoption and current e-invoicing development in China is conducted. A research model integrated by the diffusion of innovation theory, the technology, organization, and environment framework and Iacovou et al. (1995) m...
Rahman, Md Motiar
Building Information Modelling (BIM) is getting increased attention day-by-day due to its many benefits, including clash detection, collaboration between contract parties, visualization future structure, optimized schedule and project control, waste control, design documentation, and harmonized facilities management. As such, many countries have already adopted BIM, and many other countries are exploring the potential of adopting it. However, it is still relatively new and unknown to some other countries like Brunei. This study was therefore undertaken to generate and/or gauge the awareness of Brunei construction industry participants, targeting adoption of BIM, through a structured questionnaire survey. Responses from 90 industry participants reveal that Brunei Construction industry is not well aware of BIM, lack the required technical knowledge and application in construction, and cost involvement. They are unsure about the potential benefits and barriers to implementing BIM. However, respondents are hopeful that BIM can bring the required changes in construction, willing to adopt BIM, expects cliental support with initial investment for its adoption, and believe that BIM is the future of construction project information management. On the whole, private sector was seen to be more aware on BIM than public sector. The study outcomes are expected to provide the policy makers a first-hand information on the industry awareness on BIM, which in turn help them for further exploration / examination and to design any action plan and guidelines for BIM adoption.
Full Text Available The adoption of unrelated orphaned infants is something chimpanzees and humans have in common. Providing parental care has fitness implications for both the adopter and orphan, and cases of adoption have thus been cited as evidence for a shared origin of an altruistic behaviour. We provide new data on adoptions in the free-living Sonso chimpanzee community in Uganda, together with an analysis of published data from other long-term field sites. As a default pattern, we find that orphan chimpanzees do not become adopted by adult group members but wherever possible associate with each other, usually as maternal sibling pairs. This occurs even if both partners are still immature, with older individuals effectively becoming 'child household heads'. Adoption of orphans by unrelated individuals does occur but usually only if no maternal siblings or other relatives are present and only after significant delays. In conclusion, following the loss of their mother, orphaned chimpanzees preferentially associate along pre-existing social bonds, which are typically strongest amongst maternal siblings.
Full Text Available To date, silage adoption has been low in the tropics, particularly under smallholder conditions. Innovation and adoption processes of silage technologies were promoted in drought-constrained areas of Honduras using a flexible, site-specific and participatory research and extension approach. A total of about 250 farmers participated in training workshops and field days conducted in 13 locations. Smallholders successfully ensiled maize, sorghum and/or Pennisetum spp., mainly in heap and earth silos, while adoption of little bag silage (LBS was low. LBS proved useful as a demonstration, experimentation and learning tool. A ‘silage boom’ occurred in 5 locations, where favorable adoption conditions included the presence of demonstration farms and involvement of key innovators, lack of alternative dry season feeds, perceived benefits of silage feeding, a favorable milk market and both extension continuity and intensity. The lack of chopping equipment was the main reason for non-adoption by poor smallholders. The study showed that, when targeting production system needs and farmer demands, silage promotion can lead to significant adoption, including at smallholder level, in the tropics. This experience could contribute to an increase in effectiveness and sustainability of silage extension in similar situations elsewhere.
Mason, Patrick; Narad, Christine
Adoptions from international countries have become an option for many US families, with over 150,000 children adopted in the past 14 years. Typically, internationally adopted children present with a host of medical and developmental concerns. Issues such as growth stunting, abnormal behaviors, and significant delays in motor, speech, and language development are likely directly related to the prenatal and early postnatal environment experienced prior to adoption. The new family and its health-care team must quickly work to identify and address these issues to aid the child's integration into his or her new family. This article will examine potential issues seen in children who are being adopted, including the impact of early environment on subsequent development. We will summarize early and long-term medical issues and review the extent of developmental delays seen in children adopted internationally. Finally, we will discuss possible mechanisms leading to the observed delays, including the impact of stress on subsequent development. By understanding the extent of expected delays and the mechanisms likely causing the issues, the health-care team will be in a good position to quickly identify and develop intervention protocols that will foster the child's assimilation into his or her new family.
Bergenholtz, Carsten; Bjerregaard, Toke
The present study investigates how a high-tech-small-firm (HTSF) can carry out an inter-organizational search of actors located at universities. Responding to calls to study how firms navigate multiple institutional norms, this research examines the different strategies used by a HTSF to balance...... adopted academic norm-sets, commercial imperatives and formal regulations to support formation of networks and collaborations with universities. The findings show how the significance of weak and strong ties for the formation of collaborations and networks with universities is relative...
Hayes, Kathryn J; Eljiz, Kathy; Dadich, Ann; Fitzgerald, Janna-Anneke; Sloan, Terry
The purpose of this paper is to provide a retrospective analysis of computer simulation's role in accelerating individual innovation adoption decisions. The process innovation examined is Lean Systems Thinking, and the organizational context is the imaging department of an Australian public hospital. Intrinsic case study methods including observation, interviews with radiology and emergency personnel about scheduling procedures, mapping patient appointment processes and document analysis were used over three years and then complemented with retrospective interviews with key hospital staff. The multiple data sources and methods were combined in a pragmatic and reflexive manner to explore an extreme case that provides potential to act as an instructive template for effective change. Computer simulation of process change ideas offered by staff to improve patient-flow accelerated the adoption of the process changes, largely because animated computer simulation permitted experimentation (trialability), provided observable predictions of change results (observability) and minimized perceived risk. The difficulty of making accurate comparisons between time periods in a health care setting is acknowledged. This work has implications for policy, practice and theory, particularly for inducing the rapid diffusion of process innovations to address challenges facing health service organizations and national health systems. Originality/value - The research demonstrates the value of animated computer simulation in presenting the need for change, identifying options, and predicting change outcomes and is the first work to indicate the importance of trialability, observability and risk reduction in individual adoption decisions in health services.
Asano, Hiroshi; Nishio, Ken-ichiro; Imanaka, Takeo; Imamura, Ei-ichi
This paper presents the modeling of customer adoption of distributed generation (DG) in industrial and residential sectors in Japan. We classified the DG market into an existing industrial DG market that is based on conventional prime movers (steam turbines, diesel engines, gas turbines, and gas engines) and a new residential DG market that is based on micro gas engines and fuel cell technology. Customers adopt self-generation considering the different prime movers and thermally activated equipment, fuel choice, growth of industrial output, and energy demand. The trend of the installed capacity of each prime mover shows different diffusion patterns. We conducted regression analysis of time-series data of self-generating facilities for the period from 1983 to 2001. We also modeled residential customer adoption of polymer electrolyte fuel cells and micro engine cogeneration systems (CGSs) until 2020. The feature of this model is the dynamic choice of multiple technologies such as gas CGSs and heat-pump water heaters. Sensitivity analysis of energy efficiency and the initial cost of energy systems for technology diffusion reveal alternative penetration paths and impacts on energy consumption and CO2 emission. (Author)
Bernedo Muñoz, Isabel María; Fuentes Rebollo, María Jesús; Fernández-Molina, M; Bersabé Morán, Rosa
Although parental socialization styles have been investigated in recent years, little research has been carried out on the issue of parental styles in adoptive families. The aim of this research is to analyse parental styles both from the point of view of the parents and of adopted and non-adopted adolescents, taking as covariables the adolescents' sex and age. The sample was made up of 55 adopted adolescents (20 boys and 35 girls with an age range of 11-17 years) and their 55 adoptive parents, and 402 non-adopted adolescents (200 boys and 202 girls with an age range of 11-17 years), and their 258 parents. Two scales evaluated parental styles: the Affect Scale and the Rules and Demands Scale. The results showed that, both from the point of view of the parents and of the adolescents, adoptive families are more affective, communicative and inductive, and less critical and indulgent than non-adoptive families. No differences were found between adopted and non-adopted adolescents on the Parents' Rigidity Scale.
Hellerstedt, Wendy L; Madsen, Nikki J; Gunnar, Megan R; Grotevant, Harold D; Lee, Richard M; Johnson, Dana E
To conduct the first population-based surveillance in the United States of parents who adopted children from countries outside of the United States. A 556-item survey was mailed to 2,977 parents who finalized an international adoption in Minnesota between January 1990 and December 1998; 1,834 (62%) parents returned a survey. Eighty-eight percent of the parents reported transracial adoptions (97% of the parents were white); 57% of the adopted children were Asian; 60% were female; and on average, the children were 18 months-old at the time of placement. Only 15% of the parents reported household annual incomes less than $50,000 and 71% reported they had college educations. Sixty-one percent traveled to their child's country of birth prior to the adoption. Almost three-quarters involved their children in experiences related to their birth countries and 98% would recommend international adoption. Three-quarters of the parents believe that parental leave was an issue for them as they adopted. This is the first population-based survey of U.S. parents who have adopted internationally. The adoptive parents were socioeconomically different than birth parents in Minnesota and their families are most likely to be transracial. Because international adoption has become more prevalent, it is important to understand the strengths and needs of families that are created through this unique form of migration.
Feyerabend e a máxima do "Tudo Vale": A necessidade de se adotar múltiplas possibilidades de metodologia na construção de teorias científicas Feyerabend and the Aphorism "anything goes", the need to adopt multiple possibilities of the methodology in the construction of scientific theories
Luis Flávio Couto
Full Text Available O objetivo deste ensaio é apresentar uma visão geral da crítica de Paul Feyerabend da metodologia científica e, mais precisamente, sobre a exigência da adoção de uma postura flexível frente à construção e à afirmação de veracidade de hipóteses científicas. A máxima que deve regê-las deve ser "tudo vale". O ensaio aponta as razões históricas que justificam, em certa medida e tomando-se cuidado frente a tal voluntarismo teórico, a adoção dessa abertura a novos pressupostos em ciência. No ensaio, defende-se o pressuposto de que não existem condições que limitem indefinidamente a pesquisa. Afirma-se também que não há uma única teoria capaz de apreender o objeto em seu todo, da mesma forma como o próprio processo de investigação é inesgotável.The objective of this essay is to give an overview of Paul Feyerabend’s review of scientific methodology, and more precisely, the requiriment of the adoption of a more flexible attitude towards the construction and the statement of the veracity of scientific hypotheses. The ruling principle is "anything goes". This essay points to the historical reasons that left, to an extent and taking the due care with such theoretical voluntarism, the adoption of this opening to new presuppositions in science. It is proposed that there are not conditions which limit research indefinitely. There is not a single theory able to capture the object in its entirety in the same way that the investigation process itself is inexhaustible.
Full Text Available Explanatory models of e-Government adoption are based on the premise that user behavior results from users’ intentions, which derive from users’ beliefs and attitudes. According to such models, citizens’ high intentions to use e-Government tools should have led to the widespread adoption of these tools. Yet this has not occurred. Therefore, existing models fail to explain the adoption of e-Government. These models must be complemented to explain the cause of citizens’ failure to adopt e-Government. Attempts to build a satisfactory model include the design of dual models (jointly analyzing facilitators and inhibitors and integrating models (jointly analyzing the interaction between intention and habit in prompting behavior. This study identified several inhibitors of e-Government adoption. Organizational support, self-efficacy, benefits, loss aversion, regret aversion, control, transition costs, sunk costs/switching costs, uncertainty, habit, resistance, and inertia were found to inhibit citizens’ adoption of e-Government.
Renata Nogueira Braga
Full Text Available ABSTRACT This study investigates the association between mandatory International Financial Reporting Standards (IFRS adoption and corporate tax avoidance. In this study, tax avoidance is defined as a reduction in the effective corporate income tax rate through tax planning activities, whether these are legal, questionable, or even illegal. Three measures of tax avoidance are used and factors at the country and firm level (that have already been associated with tax avoidance in prior research are controlled. Using samples that range from 9,389 to 15,423 publicly-traded companies from 35 countries, covering 1999 to 2014, it is found that IFRS adoption is associated with higher levels of corporate tax avoidance, even when the level of book-tax conformity required in the countries and the volume of accruals are controlled, both of which are considered potential determinants of this relationship. Furthermore, the results suggest that after IFRS adoption, firms in higher book-tax conformity environments engage more in tax avoidance than firms in lower book-tax conformity environments. It is also identified that engagement in tax avoidance after IFRS adoption derives not only from accruals management, but also from practices that do not involve accruals. The main conclusion is that companies engage more in tax avoidance after mandatory IFRS adoption.
Fernández-Mayoralas, Daniel Martín; Fernández-Perrone, Ana L; López-Arribas, Sonia; Pelaz-Antolín, Antonio; Fernández-Jaén, Alberto
The term adoption or adoptive filiation is understood as referring to the legal act by which family ties are created between two persons such that a relationship of fatherhood or motherhood is established between them. AIMS. The purpose of this study is to outline the problems derived from prenatal exposure to alcohol and other risk factors, from hypostimulation during the 'critical period' in institutionalised patients (especially those adopted from eastern European countries) and their relation with attention deficit hyperactivity disorder (ADHD). This work also seeks to take a deeper look into the diagnosis, prevention and treatment of these problems. These children have problems in terms of psychosocial relationships, behavioural problems, delayed language or reading development and, above all, ADHD. In practice it is extremely difficult to separate the two factors during the assessment of children adopted from eastern European countries in neuropaediatric consultations. Exactly how all these factors are interrelated is not well understood. There is a close relationship between prenatal exposure to alcohol and the consequences of adoption. There is a need for placebo-controlled randomised studies, with larger population samples, that test the benefits and profile of side effects, both with psychostimulants and with atomoxetine in this group of patients.
This presentation discussed drivers and incentives for the widespread adoption of electric vehicles (EVs) as well as the potential impacts on electric utility customers. For many drivers, the adoption of EVs will result in fuel cost savings of $1200 per year. Approximately 73 per cent of Canada's population is concentrated in urban areas. Ninety-five per cent of car trips are less than 30 km in distance. Canada's federal and provincial governments support the adoption of EVs. British Columbia (BC) currently has the most attractive combination of low electricity prices and high fuel costs in North America. Provincial sales tax rebates of up to $2000 are available for EV adopters, while carbon taxes are now being applied to fossil fuel users. New homes in Vancouver are required to provide dedicated charging circuits for EVs. The use of EVs will create new demands for customer service from fuel retailers, developers, fleets and consumer services. BC is expected to have one of the highest EV adoption rates in North America. Unconstrained EV charging is expected to impact the electricity grid by 2015. tabs., figs.
Diane L. Whitaker-Worth, MD
Full Text Available Over 200,000 children have been adopted into United States (US families from abroad since the year 2000. Health care providers who care for children adopted internationally should be aware of the spectrum of illnesses seen in this population, and should be prepared to encounter potentially unusual situations. An appreciation for the unique pre-adoption exposures and vulnerabilities inherent in international adoption is critical for proper diagnosis and treatment of this heterogeneous group of children. It is important to consider the impact of potential early childhood stressors such as nutritional, sensory, and emotional deprivation, trauma and abuse, as well as prenatal exposures to drugs, alcohol, and infectious diseases. Providers must also take into account international variation in health care practices, including immunization, treatment, surgical, and hygiene standards. The differential diagnosis for cutaneous eruptions in children adopted internationally is broad and must encompass endemic systemic illnesses with skin manifestations, such as measles, tuberculosis, leprosy, and congenital syphilis, and primary dermatologic diseases such as scabies and bacterial and fungal infections. The importance of maintaining a broad differential and open mind when addressing the dermatologic needs of these children cannot be overemphasized.
This chapter discusses the relationship between health insurance and hospitals' decisions to adopt medical technologies. I focus on both how the extent of insurance coverage can increase incentives to adopt new treatments, and how the parameters of the insurance contract can impact the types of treatments adopted. I provide a review of the previous theoretical and empirical literature and highlight evidence on this relationship from previous expansions of Medicaid eligibility to low-income pregnant women. While health insurance has important effects on individual-level choices of health care consumption, increases in the fraction of the population covered by insurance has also been found to have broader supply side effects as hospitals respond to changes in demand by changing the type of care offered. Furthermore, hospitals respond to the design of insurance contracts and adopt more or less cost-effective technologies depending on the incentive system. Understanding how insurance changes supply side incentives is important as we consider future changes in the insurance landscape. ORIGINALITY/VALUE OF PAPER: With these previous findings in mind, I conclude with a discussion of how the Affordable Care Act may alter hospital technology adoption incentives by both expanding coverage and changing payment schemes.
Grunwald, I.Q.; Kuehn, A.L.; Backens, M.; Papanagiotou, P.; Shariat, K.; Kostopoulos, P.
Multiple sclerosis is the most common chronic inflammatory disease of myelin with interspersed lesions in the white matter of the central nervous system. Magnetic resonance imaging (MRI) plays a key role in the diagnosis and monitoring of white matter diseases. This article focuses on key findings in multiple sclerosis as detected by MRI. (orig.) [de
Full Text Available This paper explores the major factors impacting upon the ecological adoption of solar water heaters in Mauritius. The paper applies data reduction technique by using exploratory factor analysis on a sample of 228 respondents and condenses a set of 32 attributes into a list of 8 comprehensible factors impacting upon the sustained adoption of solar water heater in Mauritius. Multiple regression analysis was also conducted to investigate upon the most predictive factor influencing the adoption of solar water heaters in Mauritius. The empirical estimates of the regression analysis have also depicted that the most determining factor pertaining to the ‘government incentives for solar water heaters’ impacts upon the adoption of solar water heaters. These results can be related to sustainable adoption of green energy whereby targeted incentive mechanisms can be formulated with the aim to accelerate and cascade solar energy adoption in emerging economies. A novel conceptual model was also proposed in this paper, whereby, ecological stakeholders in the sustainable arena could use the model as a reference to pave the way to encourage adoption of solar water heating energy. This research represents a different way of understanding ecological customers by developing an expanding on an original scale development for the survey on the ecological adoption of solar water heaters.
Full Text Available This study tried to describe the behavior intention factors related to adopt the innovative bidet toilet seats in the households. The increase of the middle class population in Indonesia creates a new demand for adopting innovative products to enhance lifestyles. There were many electronic home appliance products have been easily adopted in Jakarta households, however there has been low adoption for electronic bidet toilet seats in household bathrooms. This study aims to identify and analyse the critical factors involved in adopting these seats in households and to explore the relative significance of each of these factors. It reports the results of empirical tests conducted regarding the non users’ adoption of these seats, based on the extended Theory of Planned Behavior. This study was administrated to 115 participants in Jakarta. Descriptive statistic, correlation analysis and multiple regressions were performed to determine the important factors. The results indicate that intention, voluntariness, observability, water usage and age are positively influence the adoption of the seats in urban households in Jakarta. Keywords: behavior adoption, electronic bidet toilet seats, urban households, jakarta
Leighton, Kimberly J
An increasing number of children are adopted in the United States from countries where both medical care and environmental conditions are extremely poor. In response to worries about the accuracy of medical histories, prospective adoptive parents increasingly request genetic testing of children prior to adoption. Though a general consensus on the ethics of pre-adoption genetic testing (PAGT) argues against permitting genetic testing on children available for adoption that is not also permitted for children in general, a view gaining traction argues for expanding the tests permitted. The reasoning behind this view is that the State has a duty to provide a child with parents who are the best "match," and thus all information that advances this end should be obtained. While the matching argument aims to promote the best interests of children, I show how it rests on the claim that what is in the best interests of children available for adoption is for prospective adoptive parents to have their genetic preferences satisfied such that the "genetics" of the children they end up adopting accurately reflects those preferences. Instead of protecting a vulnerable population, I conclude, PAGT contributes to the risks of harm such children face as it encourages people with strong genetic preferences to adopt children whose genetic backgrounds will always be uncertain.
Goldberg, Abbie E; Smith, JuliAnna Z
Using a sample of 125 lesbian, gay, and heterosexual adoptive parent couples with young children (M = 6.32 years), this study examined predictors of direct socialization (preparation for adoptism, racism, and heterosexism) and indirect socialization (modeling interactions by responding to outsiders' inquiries about their child's adoptive status, racial background, or family structure). In terms of direct socialization, parents of older children tended to engage in more socialization around adoptism and heterosexism, and parents of daughters tended to engage in more socialization around racism and heterosexism. Greater perceived child interest in adoption was related to more direct socialization around adoptism. Parents of color reported more direct socialization around racism. Having a child of color was related to more direct socialization around heterosexism. Regarding indirect socialization, sexual minority parents reported more socialization around adoption and race. Greater perceived child interest in adoption was related to more indirect adoption socialization. Being more "out" was related to more indirect socialization around parent sexual orientation. (c) 2016 APA, all rights reserved).
Aalbers, Rob [Netherlands Bureau for Economic Policy Analysis, P.O. Box 80510, 2508 GM The Hague (Netherlands); Van der Heijden, Eline; Potters, Jan [CentER and Department of Economics, Tilburg University, P.O. Box 90153, 5000 LE Tilburg (Netherlands); Van Soest, Daan [Department of Spatial Economics/IVM, VU University, De Boelelaan 1105, 1081 HV Amsterdam (Netherlands); Vollebergh, Herman [Tinbergen Institute, Erasmus University Rotterdam and Netherlands Environmental Assessment Agency, P.O. Box 303, 3720 AH Bilthoven (Netherlands)
We evaluate the impact of technology adoption subsidies on investment behavior in an individual choice experiment. In a laboratory setting professional managers are confronted with an intertemporal decision problem in which they have to decide whether or not to search for, and possibly adopt, a new technology. Technologies differ in the per-period benefits they yield, and their purchase price increases with the per-period benefits provided. We introduce a subsidy on the more expensive technologies (that also yield larger per-period benefits), and find that the subsidy scheme induces agents to search for and adopt these more expensive technologies even though the subsidy itself is too small to render these technologies profitable. We speculate that the result is driven by the positive connotation (affect) that the concept 'subsidy' invokes. (author)
Bryan, Stirling; Mitton, Craig; Donaldson, Cam
A major driver of cost growth in health care is the rapid increase in the utilisation of existing technology and not simply the adoption of new technology. Health economists and their health technology assessment colleagues have become obsessed by technology adoption questions and have largely ignored 'technology management' questions. Technology management would include the life-cycle assessment of technologies in use, to assess their real-world performance; and monitoring of technology indication creep. A rebalancing of focus might serve to encourage a more self-critical and learning culture amongst those involved in technology evaluation analysis. Further, health economists and health technology assessment analysts could make a more significant contribution to system efficiency through rebalancing their efforts away from technology adoption questions towards technology management issues. Copyright © 2014 John Wiley & Sons, Ltd.
Bunker, Deborah; Kautz, Karlheinz; Nguyen, Anne Luu Thanh
Compatibility has been recognised as an important element in the adoption of IT innovations in organisations but as a concept it has been generally limited to technical or functional factors. Compatibility is also significant, however, with regard to value compatibility between the organisation......, and the adopted IT innovation. We propose a framework to determine value compatibility analysing the organisation's and information system's structure, practices and culture, and explore the value compatibility of an organisation with its adopted self-service computer-based information system. A case study...... was conducted to determine the congruence of an organisation's value and IT value compatibility. This study found that there was a high correspondence in the organisational structure and practice dimensions; however, there were organisational culture disparities. The cultural disparities reflected the self...
Aalbers, Rob; Van der Heijden, Eline; Potters, Jan; Van Soest, Daan; Vollebergh, Herman
We evaluate the impact of technology adoption subsidies on investment behavior in an individual choice experiment. In a laboratory setting professional managers are confronted with an intertemporal decision problem in which they have to decide whether or not to search for, and possibly adopt, a new technology. Technologies differ in the per-period benefits they yield, and their purchase price increases with the per-period benefits provided. We introduce a subsidy on the more expensive technologies (that also yield larger per-period benefits), and find that the subsidy scheme induces agents to search for and adopt these more expensive technologies even though the subsidy itself is too small to render these technologies profitable. We speculate that the result is driven by the positive connotation (affect) that the concept 'subsidy' invokes. (author)
This chapter presents the results of a study on factors affecting adoption of e-commerce in small and medium size enterprises in Australia. The Tornatsky and Fleischer (1990) model is used in the investigation therefore the main group of factors taken into consideration are environmental, organiz......This chapter presents the results of a study on factors affecting adoption of e-commerce in small and medium size enterprises in Australia. The Tornatsky and Fleischer (1990) model is used in the investigation therefore the main group of factors taken into consideration are environmental......, organizational and technological. Top managers employed in five companies located in the area of Brisbane, Queensland have been interviewed. The results are partially in line with similar studies on e-commerce adoption in SMEs. However many differences are also found. For example this study found...
Murphy, Timothy F
Anja Karnein has suggested that because of the importance of respect for persons, law and policy should require some human embryos created in vitro to be available for adoption for a period of time. If no one comes forward to adopt the embryos during that time, they may be destroyed (in the case of embryos left over from fertility medicine) or used in research (in the case of embryos created for that purpose or left over from fertility medicine). This adoption option would increase the number of embryos available for couples looking for help in having children, but that effect is less important--Karnein argues--than the observance of respect for human persons. As possible persons, she holds that embryos ought to be treated, as if they will become children, if only for a while. If enacted as a matter of law and policy, an 'adoption option' would wrongly interfere with the dispositional rights women and men ought to have over embryos they create in the course of trying to have children. Karnein's proposal would also deprive researchers of certainty that the embryos they create for research would actually be available that way, leading to increased burdens of time and money and maybe even to more embryos than would otherwise be produced. Karnein's analysis does not show, moreover, that any duty of rescue applies to embryos. No woman is required to adopt any embryo, which significantly undercuts the justification for an obligatory adoption period. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Pedersen, Søren Marcus; Fountas, S.; Blackmore, S.
to demonstrate continuous yield improvements from Variable Rate Technology applications. The cost of gathering information, time consumption and incompatibility are barriers to adoption. Given teh uncertainty due to temporal variability, real time canopy management with N-sensors and weed detection is suggested......The adoption of precision farming (PF)in Denmark has been studied through two mail surveys, personal interviews and focus groups with farmers and other stakeholders. Farmers are in general optimistic about PF but it is difficult to verify the economic and environmental gains. It has been difficult...
Cunha-e-Sa, Maria A.; Balcao Reis, Ana; Roseta-Palma, Catarina
Technological change has played an important role in models of nonrenewable resource management, since its presence mitigates the depletion effect on extraction costs over time. We formalize the problem of a competitive nonrenewable resource extracting firm faced with the possibility of technology adoption. Based on a quadratic extraction cost function, our results show that the expected net benefits from adoption increase both with the size of the resource stock and with prices. A boundary that separates the region where expected net benefits are positive from the one where they are negative is derived. (author)
Tjørnehøj, Gitte; Mathiassen, Lars
firm, SmallSoft, over a 10-year period (1996–2005). We found that micro-level and macro-level improvisations interacted, often in uncoordinated ways, to shape SPI technology adoption at SmallSoft. The improvisations enhanced employee creativity, motivation and empowerment, created momentum......Most software firms struggle to take advantage of the potential benefits of software process improvement (SPI) as they adopt this technology into the complex and dynamic realities of their day-to-day operation. Such efforts are therefore typically fluctuating between management's attempt to control...
McGuinness, Teena M; Dyer, Janyce G
International adoption research has been called a natural experiment by many child development researchers. How do studies of severe early deprivation inform us about risk factors experienced by many of these children and their impact on developmental outcomes? Three longitudinal studies conducted by British and American researchers in the 1990s are reviewed. Each year, over 20,000 children are adopted from overseas, and a significant number are now entering adolescence; the impact of their prenatal risk factors, early institutionalization, and ameliorative postadoptive environments is also reviewed. The feasibility of generalizing findings to other children in foster care is also addressed.
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Relationship resulting from legal adoption... RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Child § 222.33 Relationship resulting from legal adoption... applicable State law. Legal adoption differs from equitable adoption in that in the case of legal adoption...
Ayu Intan Sari
longer experience, and higher level of active searching information seemed to have higher probability to become the early adopter. The farmers having higher perception of innovation characteristics, relative advantage and observability, and lower perception of complexity innovation characteristic tended to be early adopter. (Key words: Adopter category, Adoption, Herbal feed additive
Brown, Suzanne; Groza, Victor
The Hague Convention on the Protection of Children suggests that intercountry adoption be considered as a permanent care option only after other solutions within the child's country of origin have been exhausted. Data from the Child Behavior Checklist (CBCL) were examined for 478 Indian children ages 4-18 adopted domestically, adopted to Norway, and adopted to the United States. The CBCL has a reported reliability of .9 (Achenbach, 1991; Achenbach & Edelbrock, 1983) and contains five subscales assessing internalizing problems plus a summative Internalizing Scale, and three subscales assessing externalizing problems plus a summative Externalizing Scale. Perceptions of Norwegian, American, and Indian adoptive parents regarding their child's functioning were compared. Children adopted to Norway and the United States were perceived by their parents to be functioning significantly better behaviorally than children adopted within country, while controlling for age of child and gender of adoptive parent completing the CBCL. Policymakers should examine the evidence prioritizing within country adoption over intercountry adoption.
Nykiforuk, Candace I J; Campbell, Elizabeth J; Macridis, Soultana; McKennitt, Daniel; Atkey, Kayla; Raine, Kim D
Healthy public policy is an important tool for creating environments that support human health and wellbeing. At the local level, municipal policies, such as zoning bylaws, provide an opportunity for governments to regulate building location and the type of services offered. Across North America, there has been a recent proliferation of municipal bylaws banning fast food drive-through services. Research on the utilization of this policy strategy, including bylaw adopters and adopter characteristics, is limited within the Canadian context. The aim of this study was to identify and characterize Canadian municipalities based on level of policy innovation and nature of their adopted bylaw banning fast food drive-through services. A multiple case history methodology was utilized to identify and analyse eligible municipal bylaws, and included development of a chronological timeline and map of adopter municipalities within Canada. Grey literature and policy databases were searched for potential adopters of municipal fast food drive-through service bylaws. Adopters were confirmed through evidence of current municipal bylaws. Geographic diffusion and diffusion of innovations theories provided a contextual framework for analysis of bylaw documents. Analysis included assignment of adopter-types, extent and purpose of bans, and policy learning activities of each adopter municipality. From 2002 to 2016, 27 municipalities were identified as adopters: six innovators and twenty-one early adopters. Mapping revealed parallel geographic diffusion patterns in western and eastern Canada. Twenty-two municipalities adopted a partial ban and five adopted a full ban. Rationales for the drive-through bans included health promotion, environmental concerns from idling, community character and aesthetics, traffic concerns, and walkability. Policy learning, including research and consultation with other municipalities, was performed by nine early adopters. This study detailed the adoption of
Collins, Conor D
Advances in the imaging and treatment of multiple myeloma have occurred over the past decade. This article summarises the current status and highlights how an understanding of both is necessary for optimum management.
... read or download the National Academies/Institute of Medicine report, go to: " Multiple Sclerosis: Current Status and Strategies for the Future ." Information from the National Library of Medicine’s MedlinePlus ...
Reppold, Caroline Tozzi; Hutz, Claudio Simon
Since the decade of 1980, the model of stress and coping proposed for the assessment of vulnerability of adoptive families emphasizes that the emotional adjustment of those adopted is moderated by variables such as institutionalization, the manner and age at which the adoption was revealed, the change of first name, and the contact with the biological family. The objective of this study was to investigate the relationship of these variables to the perceived parenting style, mood, and self-esteem of the adopted adolescents. Participants in the study were 68 adolescents, between the ages of 14 and 15, adopted during infancy through judicial channels. The adolescents responded to a questionnaire about the history of adoption and to scales of Parenting Styles, Depression and Self-esteem. The main results indicated that the late revelation of adoption and the change of the first name are connected to higher levels of depression and low self-esteem and to more frequent perceptions of negligent or authoritarian parenting style. The contact with the biological family was frequently mentioned among those who perceived their parents as authoritative and presented the best indicator of mood and self-esteem. These findings were discussed in light of the necessity for multidisciplinary actions which can improve the psychological adaptation of the adopting families.
Matthews, John D.; Cramer, Elizabeth P.
Although a growing number of child placement agencies are serving lesbians and gay men, a dearth of literature exists for adoption agency policies and practices related to working with this population. This article explores the unique characteristics and strengths of prospective gay and lesbian adoptive parents throughout each of the three phases…
Until recently there has been little formal guidance on procedures for adopting new methods in water microbiology. However, the European Union Drinking Water Directive of 1998 specified methods that were to be used for the microbiological parameters, most being ISO methods, but allowed the use of alternative methods ...
This study examines the International Financial Accounting Reporting Standards adoption practices around the world and the way these practices are reflected in the financial statements of companies in different countries. It also examines the incentives/ motivations for the variations in the type of International Financial ...
Prof. Adipala Ekwamu
Saharan Africa. A new technology known as imazapyr-resistant maize (IRM) has proven to be effective in controlling it. This study examined the status of IRM adoption in western Kenya. A cross sectional survey that included 600 households, ...
This Paper centres on the factors influencing the adoption of white egg shelled layers among poultry farmers in Ogun State, Nigeria. It relied on the primary data collected from 96 randomly selected poultry farmers from five local government areas of Ogun state, Nigeria. The analytical techniques used are descriptive ...
Soil erosion is a serious constraint for agriculture and rural development in developing countries. Many efforts are made to promote soil and water conservation (SWC) among farm households. However, adoption of SWC practices is often disappointing. This thesis analyses the benefits of terraces and
The value of successful adoption of Model Based System Engineering (MBSE) practices is hard to quantify. Most engineers and project managers look at the success in terms of cost. But there are other ways to quantify the value of MBSE and the steps necessary to achieve adoption. The Glenn Research Center (GRC) has been doing Model-Based Engineering (design, structural, etc.) for years, but the system engineering side has not. Since 2010, GRC has been moving from documents centric to MBSE/SysML. Project adoption of MBSE has been slow, but is steadily increasing in both MBSE usage and complexity of generated products. Sharing of knowledge of lessons learned in the implementation of MBSE/SysML is key for others who want to be successful. Along with GRC's implementation, NASA is working hard to increase the successful implementation of MBSE across all the other centers by developing guidelines, templates and libraries for projects to utilize. This presentation will provide insight into recent GRC and NASA adoption efforts, lessons learned and best practices.
Afendulis, Christopher C; Caudry, Daryl J; O'Malley, A James; Kemper, Peter; Grabowski, David C
To evaluate the impact of the Green House (GH) model on nursing home resident-level quality of care measures. Resident-level minimum data set (MDS) assessments merged with Medicare inpatient claims for the period 2005 through 2010. Using a difference-in-differences framework, we compared changes in care quality and outcomes in 15 nursing homes that adopted the GH model relative to changes over the same time period in 223 matched nursing homes that had not adopted the GH model. For individuals residing in GH homes, adoption of the model lowered readmissions and several MDS measures of poor quality, including bedfast residents, catheter use, and pressure ulcers, but these results were not present across the entire GH organization, suggesting possible offsetting effects for residents of non-GH "legacy" units within the GH organization. GH adoption led to improvement in rehospitalizations and certain nursing home quality measures for individuals residing in a GH home. The absence of evidence of a decline in other clinical quality measures in GH nursing homes should reassure anyone concerned that GH might have sacrificed clinical quality for improved quality of life. © Health Research and Educational Trust.
The study analyzed the strategies adopted by rural women associations in community development activities in Sagbama Local Government Area of the Niger Delta, Nigeria. Data for the study were obtained through a structured and validated interview schedule administered to a sample size of 60 respondents from 15 ...
The study was on the adoption of selected agricultural technologies of Anambra State Agricultural Development programme by small scale farmers in Anambra State. Data were collected from purposively sampled 120 farmers in the state using structured interview schedule. The data were analyzed using percentages and ...
May 2, 2008 ... The study determined farmers' adoption of improved agricultural technologies disseminated via radio ... questions and get feed back from the radio presenter and language used in presenting the programme. The study recommends ... attitude, knowledge, skills and aspiration of the receivers. In Nigeria ...
Leonard-Barton, Dorothy; Rogers, Everett M.
In spring 1977, just as California was emerging from one of the worst droughts in its history, 215 Palo Alto homeowners were interviewed about their views on energy and water conservation, and about the extent to which they had adopted 11 energy-conserving practices (ECP) in the home. The objective was to discover variables both important to…
Tjørnehøj, Gitte; Mathiassen, Lars
Most software firms struggle to take advantage of the potential benefits of software process improvement (SPI) as they adopt this technology into the complex and dynamic realities of their day-to-day operation. Such efforts are therefore typically fluctuating between management's attempt to contr...
Florman, Jean C.
This chapter introduces a University of Iowa effort to enhance and support active learning pedagogies in technology-enhanced (TILE) classrooms and three elements that proved essential to the campus-wide adoption of those pedagogies. It then describes the impact of those professional development efforts on the curricula and cultures of three…
The study examined the integrated rural development strategies adopted by communities in rural development in. Delta State. The concept of rural development was put forward and the basic idea was that it is a development process embracing the efforts of individuals, self help groups, non-governmental and governmental ...
This study assessed the level of adoption of recommended agrochemical practices among crop farmers in Kaduna and Ondo States of Nigeria. It measured the perception of farmers on pesticides and their knowledge on the harmful effects of pesticides. A total of 260 crop farmers who have sustained the use of ...
Griffith, E E; Duby, J L
This article places the controversy over transracial adoption (TRA) in its historical context and analyzes recent developments in the law governing TRA policy. Because unfounded "authority" from the field of mental health infuses current debate, the authors alert psychiatrists to two powerful forces that improperly influence today's legal arena: community preference for same-race families and biased professional norms of mental health professionals.
Levin, Michael; And Others
Michael Levin argues that data from the study are consistent with a black/white IQ difference that is significantly genetic. Richard Lynn maintains that adoption by middle-class, white families has no effect on intelligence. Waldman, Weinberg, and Scarr respond to these criticisms and support the original conclusions. (SLD)
Vonk, M. Elizabeth
Provides a clear conceptual definition of cultural competence for transracial-cultural adoptive (TRA) parents based on an extensive review of the literature and feedback from experts and parents. A three part definition of cultural competence for TRA parents includes: racial awareness, multicultural planning, and survival skills. Implications for…
The study ascertained the factors militating against adoption of improved oilpalm production technologies. A multi-stage sampling technique was used to collect data from 92 randomly selected oilpalm growers. Data were analysed using descriptive statistics and regression analysis. The results revealed that a large ...
The study determined the poultry Farmers technology adoption potentials in Abia State Nigeria. Multi-stage random sampling technique was used in the selection of local government areas, blocks, circles and respondents. Instrument of data collection was via a structured and pre-tested questionnaire. The data were ...
This paper presents an analysis of an environmental justice (EJ) program adopted by the South Coast Air Quality Management District (SCAQMD) as a part of its regulation to phase out a toxic chemical used by dry cleaners. SCAQMD provided financial incentives to switch early and gave establishments in EJ neighborhoods priority in applying for…
Abstract. This study assessed the factors influencing adoption of recommended rice production practices by women farmers in Nasarawa State. A total of 203 women rice farmers were selected for the study using multi- stage sampling procedure. Data were collected using structured interview schedule. Descriptive statistics ...
This study examined the institutional factors influencing adoption of recommended agrochemical practices (RAPs) among crop farmers in Nigeria. A total of 260 crop farmers who have sustained the use of agrochemicals for at least five years were selected for the study using multi-stage sampling technique. Data were ...
The study focused on farmers under the fadama project scheme in Edo State, Nigeria with emphasis on the relationship between farmers\\' characteristics and adoption of recommended technologies. Analyses of data obtained from a random sample of 80 respondents reveals that fadama farming was dominated by females ...
Petersen, Michael Nebeling; Myong, Lene
Rosa Morena tells a story about kinship in which a white homosexual Danish man adopts a child born to a black poor Brazilian woman. Using a theoretical framework of biopolitics and affective labour the article highlights how the male homosexual figure is being cast as heteronormative and white...
Mirza, J. S.
Discusses the adoption of online instruction for distance education in the context of the Open University of Hong Kong. Academic and non-academic services that can be offered online are described. The importance and benefits of instituting electronic tutorials are addressed, including time savings, peer interactivity, and student/tutor…
Jones, Nazarine T; Seckman, Charlotte
Best practice recommends the integration of clinical documentation into the hospital electronic health record to support safe, efficient, and timely patient care. A major barrier to successful adoption and optimization of computerized documentation systems is user satisfaction. The purpose of this descriptive, performance improvement initiative was to implement and evaluate user satisfaction with an electronic documentation system to facilitate successful adoption. The Clinical Procedure Flowsheets application was implemented in a geriatric extended care unit of a large healthcare system. Rogers' Diffusion of Innovation and Davis' Technology Acceptance Model were used to guide system adoption and improve user experience of the innovation. The Perceived Usefulness and Perceived Ease of Use questionnaire was distributed to 24 nursing staff working in the unit 9 weeks after implementation. Results indicated that respondents perceived the Clinical Procedure Flowsheets as easy to use and useful in accomplishing their documentation tasks. The overall mean satisfaction score of 72.17 (SD, 12.13) implied a strong level of user acceptance. The positive perception of the nursing staff in the geriatric extended care unit suggests a high probability of system use that can enhance the documentation of patient care. Further research is recommended to evaluate factors related to system adoption and user satisfaction.
The findings showed that the area has young, experienced, good level of education and high social participation amongst members, which is an advantage for innovation adoption and transfer. Majority inherited their cassava farms and financed them mainly through personal savings. The result showed that extension ...
The study was undertaken to determine factors influencing adoption of cocoa technologies disseminated by Olam organization to cocoa farmers in Ondo State, Nigeria. Data for the study were collected from thirty cocoa farmers (Olam's model farmers) through the use of structured interview schedule. Data were analyzed ...
Nigeria is going to adopt International Financial Reporting Standard (IFRS) from 1st January 2012. Globalization and Information and Communication Technology (ICT) has reduced the world to a global village. This has given rise to the continuous integration of the world economy and capital markets which has in turn ...
Carlin, Bruce; Olafsson, Arna; Pagel, Michaela
This paper analyzes how better access to financial information via new technology changes use of consumer credit and affects financial fitness. We exploit the introduction of a smartphone application for personal financial management as a source of exogenous variation. FinTech adoption reduces...
Rochat, Tamsen; Richter, Linda
International adoption is on the rise in the United States and is not without controversy. Reasons for the increase include higher rates of infertility in couples who have delayed parenthood; increased numbers of children who are relinquished, abandoned, or orphaned around the world; and the influence of third party agencies. Internationally…
Roby, Jini L.; Shaw, Stacey A.
The plight of Africa's AIDS orphans has reached crisis proportions, and the international community is beginning to mobilize at the family, community, national, and international levels. Despite these encouraging efforts, the response is inadequate, and increased attention and action are needed. The authors suggest that international adoption,…
Gagnon, Pieter; Sigrin, Ben
NREL staff used the dSolar (distributed solar) model to forecast the adoption of distributed, behind-the-meter PV through the year 2050 for 9 different scenarios. The scenarios varied in their assumptions about a carbon tax, the cost of PV systems in the future, and what credit would be given for excess generation once current net metering policies expire.
Lyytinen, Kalle; Damsgaard, Jan
In this article we propose a new complementary approach to investigate Inter-Organizational Information Systems (IOIS) adoption called configuration analysis. We motivate the need for a new approach by the common observation that the structure and the strategy of an IOIS are interdependent...
Miller, Laurie; Chan, Wilma; Tirella, Linda; Perrin, Ellen
Behavioral problems are frequent among post-institutionalized Eastern European adoptees. However, risk factors related to outcomes have not been fully delineated. We evaluated 50 Eastern European adoptees, age 8-10 years, with their adoptive families for more than five years. Cognitive and behavioral outcomes and parenting stress were evaluated in…
Tengvard, Maria; Palm, Jenny (Linkoeping Univ., Dept. of Technology and Social Change, Linkoeping (Sweden)). e-mail: email@example.com
In Sweden in 2008, a 'new' concept for small-scale electricity production attracted massive media attention. This was mainly due to the efforts of Swedish company Egen El, which is marketing small-scale photovoltaics (PVs) and wind turbines to households, both homeowners and tenants. Their main selling point is simplicity: their products are so easy to install that everyone can do it. Autumn 2008 also saw IKEA announce that within three years it would market solar panels. How, then, do households perceive these products? Why would households choose to buy them? How do households think about producing their own electricity? Analysis of material based on in-depth interviews with members of 20 households reveals that environmental concerns supply the main motive for adopting PVs or micro wind power generation. In some cases, the adopting households have an extensively ecological lifestyle and such adoption represents a way to take action in the energy area. For some, this investment is symbolic: a way of displaying environmental consciousness or setting an example to others. For still others, the adoption is a protest against 'the system' with its large dominant actors or is a way to become self-sufficient. These microgeneration installations are rejected mainly on economic grounds; other motives are respect for neighbours and difficulties finding a place to install a wind turbine.
Etsub [ ETSUB
ADOPTION OF IMPROVED TECHNOLOGY IN ETHIOPIA. By. Assefa Admassie and Gezahegn Ayele1. Abstract. One of the means by which farm level productivity can be increased is through the introduction and dissemination of improved agricultural technologies to farmers. This is possible if and only if, information on the ...
Full Text Available The Irish-American adoptions were a revolutionary way of dealing with Ireland’s ‘problem of the illegitimate child’. Ireland had long been promoted as a Catholic, and thus, a morally pure country. Having a child out of wedlock often resulted in the mother and child being shunned by their family and community and having little choice but to seek the help of church-run institutions. These institutions began facilitating illegal extraterritorial adoptions in 1947 to relieve the mounting pressures as those seeking their help continued to grow annually. These adoptions were heavily concerned with protecting the religious faith of the child, and this often took prominence over the quality of home. The adoptions were facilitated exclusively by these church-run institutions, allowing for complete control over the selection of prospective parents. The standards of these adoptions fell well below what was expected on the U.S. domestic scale, with no visits to the homes of prospective parents occurring, and crucially, there was no way to facilitate the reversal of an adoption. During the early life of the Irish-American adoptions, the Department of External Affairs had little involvement, only issuing passports for children that had been adopted. This changed however in 1951, as the ‘Jane Russell Case’ attracted front page media attention. The Russell case highlighted the lackadaisical approach of many of those within the Department to the exporting of some of Ireland’s youngest citizens. Undue publicity continued in the early 1950s, notably with the German newspaper, 8 Uhr Blatt. It is this media attention that forced the Department to finally address the glaring issues that severely hindered the success of the Irish-American adoptions. The Department was powerless to do anything once the child had been passed into the care of the adoptive parents. The Adoption Act 1952, marked a major turning point in the care of illegitimate children in
Kendler, K. S.; Lönn, S. Larsson; Morris, N. A.; Sundquist, J.; Långström, N.; Sundquist, K.
Background To clarify the role of genetic and environmental factors in criminal behavior (CB), we examined all CB and violent and non-violent subtypes (VCB and NVCB, respectively) in a Swedish national sample of adoptees and their relatives. Method CB was defined by a conviction in the Swedish Crime Register with standard definitions for VCB and NVCB subtypes. We examined adoptees born 1950–1991 (n=18070) and their biological (n=79206) and adoptive (n=47311) relatives. Results The risk for all CB was significantly elevated in the adopted-away offspring of biological parents of which at least one had CB [odds ratio (OR) 1.5, 95% confidence interval (CI) 1.4–1.6] and in the biological full and half-siblings of CB adoptees (OR 1.4, 95% CI 1.2–1.6 and OR 1.3, 95% CI 1.2–1.3, respectively). A genetic risk index (including biological parental/sibling history of CB and alcohol abuse) and an environmental risk index (including adoptive parental and sibling CB and a history of adoptive parental divorce, death, and medical illness) both strongly predicted probability of CB. These genetic and environmental risk indices acted additively on adoptee risk for CB. Moderate specificity was seen in the transmission of genetic risk for VCB and NVCB between biological parents and siblings and adoptees. Conclusions CB is etiologically complex and influenced by a range of genetic risk factors including a specific liability to CB and a vulnerability to broader externalizing behaviors, and by features of the adoptive environment including parental CB, divorce and death. Genetic risk factors for VCB and NVCB may be at least partially distinct. PMID:24180693
Full Text Available Application of internet by banking sector in India has changed the definition of banking completely. The management of different banks has been making concrete efforts to facilitate the acceptance of i-banking by bringing out its benefits to the customers. This paper identifies the active factors that influence customers intention regarding use of internet banking in Himachal Pradesh Data was collected from a sample of 120 respondents through a well structured questionnaire. The data was collected from Government employees of Shimla district of Himachal Pradesh by asking close ended questions regarding their attitude towards i-banking and their future intention about its use . For analysing and interpreting data in the present study, basic statistical tools, chi-square test (test of independence and logistical regression analysis was used with the help of SPSS 16.0 version. Out of seven factors i.e., perceived risk, perceived usefulness, perceived quality of service, Perceived cost, Perceived ease of use, trust and awareness, three significant factors i.e., perceived risk, perceived usefulness and perceived quality of service have been identified that actively influence future adoption intention to adopt internet banking . Further the study exhibited that perceived usefulness and perceived quality of service positively influence the intention to adopt i-banking while perceived risk negatively affect the future adoption intention of i-banking. This model has the overall predictability of classifying 76.7 % cases correctly and exhibited that 87.2 % customers are classified for adopting i-banking service whereas 57.1 % customers for not having intention to use it in future
Barros, P P; Pinto, C G; Machado, A
Technology adoption has been identified as one of the main elements behind the growth of health care expenditures. It has been argued that the health insurance arrangements in the US justify, to a certain extent, the technology-driven rise in costs. Moreover, it eases the adoption of less cost-effective procedures and devices. This paper presents an additional argument by which excessive technology investments may occur: providers of care invest in technology as a way to "signal" their intrinsic (and unobservable) quality. Providers face the option of adopting a new technology. The decision of adoption in itself may convey information about his/her quality: for example, patients conjecture that providers who display newer technology are of higher quality. Providers, being aware of this, may invest in technology to reveal themselves as high quality. Thus, technology adoption could result only from the desire to attract patients. The investment is self-defeating in the sense that if all providers invest, no information about quality is transmitted to patients. We evaluate the argument in a context of demand for health care services where patients have initially no information about the quality of different providers. We show that an incentive to invest as a way to signal quality may or may not lead to overinvestment. It is also possible that only some providers invest. They reveal themselves as high quality providers. The analysis suggests that the argument is more important for some services than for others. Overall, an additional argument for overinvestment in technology in some circumstances is provided.
-adopters. ... give a good results and also a threat to food security. Keywords: ..... government instead of planting. Table 2: Institutional factors that affect adoption of improved rice varieties. Variables. Categories Numbers. Fast. Adopters. Slow.
Nurkaliza Bt Khalid
Electronic materials such as e-book have become increasingly accepted as learning tools in the classroom nowadays. This study investigated the relationships between the big five personality traits: conscientiousness, agreeableness, neuroticism, openness to experience, and extroversion with e-book adoption among college students. Pearson Product Moment Correlation and Multiple Regressions were conducted to analyze the data. Results revealed statistically significant relatio...
Hajisoteriou, Christina; Angelides, Panayiotis
Globalisation has heavily influenced the terrain of intercultural education policy development and implementation in multiple countries around the world. To this end, in this article, we seek to introduce a broader focus of analysis encompassing not only the development of globalised policies of intercultural education, but also the adoption,…
Coughlan, Peter; Dew, Nicholas; Gates, William
.... To better understand DOD's technology adoption challenges, we review the technology diffusion literature to identify factors associated with successful and unsuccessful technology adoption processes...
Harf, Aurélie; Skandrani, Sara; Sibeoni, Jordan; Pontvert, Caroline; Revah-Levy, Anne; Moro, Marie Rose
Approximately 30 000 children are adopted across national borders each year. A review of the literature on the cultural belonging of these internationally adopted children shows substantial differences between the literature from English-speaking countries and that from France and Europe in general. The objective of this study is to start from the discourse of French adoptive parents to explore their representations of their child's cultural belonging and their positions (their thoughts and representations) concerning connections with the child's country of birth and its culture. The study includes 51 French parents who adopted one or more children internationally. Each parent participated in a semi-structured interview, focused on the adoption procedure and their current associations with the child's birth country. The interviews were analyzed according to a qualitative phenomenological method, Interpretative Phenomenological Analysis. The principal themes that emerged from our analysis of the interviews made it possible to classify the parents into three different groups. The first group maintained no association with the child's country of birth and refused any multiplicity of cultural identities. The second group actively maintained regular associations with the child's country of birth and culture and affirmed that their family was multicultural. Finally, the third group adapted their associations with the child's birth country and its culture according to the child's questions and interests. Exploring parental representations of the adopted child enables professionals involved in adoption to provide better support to these families and to do preventive work at the level of family interactions.
Harf, Aurélie; Skandrani, Sara; Sibeoni, Jordan; Pontvert, Caroline; Revah-Levy, Anne; Moro, Marie Rose
Approximately 30 000 children are adopted across national borders each year. A review of the literature on the cultural belonging of these internationally adopted children shows substantial differences between the literature from English-speaking countries and that from France and Europe in general. The objective of this study is to start from the discourse of French adoptive parents to explore their representations of their child's cultural belonging and their positions (their thoughts and representations) concerning connections with the child's country of birth and its culture. The study includes 51 French parents who adopted one or more children internationally. Each parent participated in a semi-structured interview, focused on the adoption procedure and their current associations with the child's birth country. The interviews were analyzed according to a qualitative phenomenological method, Interpretative Phenomenological Analysis. The principal themes that emerged from our analysis of the interviews made it possible to classify the parents into three different groups. The first group maintained no association with the child's country of birth and refused any multiplicity of cultural identities. The second group actively maintained regular associations with the child's country of birth and culture and affirmed that their family was multicultural. Finally, the third group adapted their associations with the child's birth country and its culture according to the child's questions and interests. Exploring parental representations of the adopted child enables professionals involved in adoption to provide better support to these families and to do preventive work at the level of family interactions. PMID:25775255
Barcons-Castel, Natalia; Fornieles-Deu, Albert; Costas-Moragas, Carme
Research on adjustment of internationally adopted children indicates that, although they have adequate development, more emotional and behavioral problems are detected compared with nonadopted children. In this research, emotional and behavioral characteristics of a sample of 52 internationally adopted minors were examined with the BASC (Parent Rating Scales and Self-Report of Personality), comparing the outcomes with 44 nonadopted minors, all of them of ages between 6 and 11 years (mean age = 8.01 years). Results indicate differences between adopted and nonadopted children related to somatization, adopted minors are those that obtain lower scores in the scale, and in the adaptability scale, where nonadopted minors obtain higher scores. Significant differences were found in the adaptive abilities scales, suggesting that nonadopted boys show better abilities than adopted ones, and no differences were found among girls. In general, boys present higher scores in externalizing symptomatology and depression than girls. Among adopted children, time spent in an institution is a variable that has negative impact on the onset of externalizing and internalizing problems. Minors coming from Eastern Europe display more attentional problems, poorer adaptive abilities and poorer interpersonal relations than the rest of the minors. According to the age at placement, attentional problems appear in minors adopted after the age of 3 years.
Pace, C S; Zavattini, G C
This study examined the attachment patterns of late-adopted children (aged 4-7) and their adoptive mothers during the first 7- to 8-month period after adoption and aimed to evaluate the effect of adoptive mothers' attachment security on the revision of the attachment patterns of their late-adopted children. We assessed attachment patterns in 20 adoptive dyads and 12 genetically related dyads at two different times: T1 (time 1) within 2 months of adoption and T2 (time 2) 6 months after T1. The children's behavioural attachment patterns were assessed using the Separation-Reunion Procedure and the children's representational (verbal) attachment patterns using the Manchester Child Attachment Story Task. The attachment models of the adoptive mothers were classified using the Adult Attachment Interview. We found that there was a significant enhancement of the late-adopted children's attachment security across the time period considered (P= 0.008). Moreover, all the late-adopted children who showed a change from insecurity to security had adoptive mothers with secure attachment models (P= 0.044). However, the matching between maternal attachment models and late-adopted children's attachment patterns (behaviours and representations) was not significant. Our data suggest that revision of the attachment patterns in the late-adopted children is possible but gradual, and that the adoptive mothers' attachment security makes it more likely to occur. © 2010 Blackwell Publishing Ltd.
H. Noppers, E.; Keizer, K.; Bockarjova, M.; Steg, L.
We investigated motivations of potential earlier and later adopters for adopting sustainable innovations. A large questionnaire study revealed that potential earlier adopters of innovative cars evaluated the symbolic attributes of electric cars, but not the instrumental and environmental attributes,
Carlson, Cathy L
Over the past 30 years, postoperative pain relief has been shown to be inadequate. To provide optimal postoperative pain relief, it is imperative for nurses to use evidence-based postoperative pain assessment practices. This correlational descriptive study was conducted to identify factors, termed prior conditions, that influenced nurses' decisions to adopt three evidence-based postoperative pain assessment practices. A convenience sample of nurses who cared for adult postoperative patients in two Midwestern hospitals were surveyed, and 443 (46.9%) nurses responded. The previous practice and innovativeness of nurses were supportive of adoption of the three practices. Nurses felt that patients received adequate pain relief, which is unsupportive of adoption of the three practices because there is no impetus to change. Nurses who perceived the prior conditions as being supportive of adoption of pain management practices used multiple sources to identify solutions to clinical practice problems, and those who read professional nursing journals were more likely to have adopted the three practices and were more innovative. The number of sources used to identify solutions to clinical practice problems, previous practices, and innovativeness were predictive of nurses' adoption of the three evidence-based postoperative pain assessment practices. Nurses need to be encouraged to use multiple sources, including professional nursing journals, to identify solutions to clinical practice problems. Innovative nurses may be considered to be opinion leaders and need to be identified to promote the adoption of evidence-based postoperative pain assessment practices. Further exploration of the large unexplained variance in adoption of evidence-based postoperative pain assessment practices is needed. Copyright © 2010 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.
Chunga, Richard M; Ensink, Jeroen H J; Jenkins, Marion W; Brown, Joe
This paper presents the results of a mixed-methods study examining adaptation strategies that property owners in low-income, rapidly urbanizing areas in Malawi adopt to address the limitations of pit latrines, the most common method of disposing human excreta. A particular challenge is lack of space for constructing new latrines as population density increases: traditional practice has been to cap full pits and simply move to a new site, but increasing demands on space require new approaches to extend the service life of latrines. In this context, we collected data on sanitation technology choices from January to September 2013 through 48 in-depth interviews and a stated preference survey targeting 1,300 property owners from 27 low-income urban areas. Results showed that property owners with concern about space for replacing pit latrines were 1.8 times more likely to select pit emptying service over the construction of new pit latrines with a slab floor (p = 0.02) but there was no significant association between concern about space for replacing pit latrines and intention to adopt locally promoted, novel sanitation technology known as ecological sanitation (ecosan). Property owners preferred to adapt existing, known technology by constructing replacement pit latrines on old pit latrine locations, reducing the frequency of replacing pit latrines, or via emptying pit latrines when full. This study highlights potential challenges to adoption of wholly new sanitation technologies, even when they present clear advantages to end users. To scale, alternative sanitation technologies for rapidly urbanising cities should offer clear advantages, be affordable, be easy to use when shared among multiple households, and their design should be informed by existing adaptation strategies and local knowledge.
Richard M Chunga
Full Text Available This paper presents the results of a mixed-methods study examining adaptation strategies that property owners in low-income, rapidly urbanizing areas in Malawi adopt to address the limitations of pit latrines, the most common method of disposing human excreta. A particular challenge is lack of space for constructing new latrines as population density increases: traditional practice has been to cap full pits and simply move to a new site, but increasing demands on space require new approaches to extend the service life of latrines. In this context, we collected data on sanitation technology choices from January to September 2013 through 48 in-depth interviews and a stated preference survey targeting 1,300 property owners from 27 low-income urban areas. Results showed that property owners with concern about space for replacing pit latrines were 1.8 times more likely to select pit emptying service over the construction of new pit latrines with a slab floor (p = 0.02 but there was no significant association between concern about space for replacing pit latrines and intention to adopt locally promoted, novel sanitation technology known as ecological sanitation (ecosan. Property owners preferred to adapt existing, known technology by constructing replacement pit latrines on old pit latrine locations, reducing the frequency of replacing pit latrines, or via emptying pit latrines when full. This study highlights potential challenges to adoption of wholly new sanitation technologies, even when they present clear advantages to end users. To scale, alternative sanitation technologies for rapidly urbanising cities should offer clear advantages, be affordable, be easy to use when shared among multiple households, and their design should be informed by existing adaptation strategies and local knowledge.
Pace, Cecilia S; Di Folco, Simona; Guerriero, Viviana; Santona, Alessandra; Terrone, Grazia
Recent literature has shown that the good outcome of adoption would mostly depend on the quality of adoptive parenting, which is strongly associated with the security of parental internal working models (IWMs) of attachment. Specifically, attachment states-of-mind of adoptive mothers classified as free and autonomous and without lack of resolution of loss or trauma could represent a good protective factor for adopted children, previously maltreated and neglected. While most research on adoptive families focused on pre-school and school-aged children, the aim of this study was to assess the concordance of IWMs of attachment in adoptive dyads during adolescence. Our pilot-study involved 76 participants: 30 adoptive mothers (mean age = 51.5 ± 4.3), and their 46 late-adopted adolescents (mean age = 13.9 ± 1.6), who were all aged 4-9 years old at time of adoption (mean age = 6.3 ± 1.5). Attachment representations of adopted adolescents were assessed by the Friend and Family Interview (FFI), while adoptive mothers' state-of-mind with respect to attachment was classified by the Adult Attachment Interview (AAI). Adolescents' verbal intelligence was controlled for. Late-adopted adolescents were classified as follows: 67% secure, 26% dismissing, and 7% preoccupied in the FFI, while their adoptive mothers' AAI classifications were 70% free-autonomous, 7% dismissing, and 23% unresolved. We found a significant concordance of 70% (32 dyads) between the secure-insecure FFI and AAI classifications. Specifically adoptive mothers with high coherence of transcript and low unresolved loss tend to have late-adopted children with high secure attachment, even if the adolescents' verbal intelligence made a significant contribution to this prediction. Our results provides an empirical contribution to the literature concerning the concordance of attachment in adoptive dyads, highlighting the beneficial impact of highly coherent states-of-mind of adoptive mothers on the attachment
Moroz, K J
This article describes the conceptualization and development of the Saturday Club for Adopted Kids (a four-session, multiage, bookwriting group for adopted children and young people) and the benefits of offering such a project-oriented group in which adoptees can tell their stories and share their experiences in an environment that supports their recovery from early trauma and offers them a way to transform the meaning of their personal losses into social action to help others. Club participants produced a book, Kids Speak Out on Adoption, based on their experiences, perceptions, and feelings.
Full Text Available The interdisciplinary study of information technology adoption has developed rapidly over the last 30 years. Various theoretical models have been developed and applied such as: the Technology Acceptance Model (TAM, Innovation Diffusion Theory (IDT, Theory of Planned Behavior (TPB, etc. The result of these many years of research is thousands of contributions to the field, which, however, remain highly fragmented. This paper develops a theoretical model of technology adoption by integrating major theories in the field: primarily IDT, TAM, and TPB. To do so while avoiding mess, an approach that goes back to basics in independent variable type’s development is proposed; emphasizing: 1 the logic of classification, and 2 psychological mechanisms behind variable types. Once developed these types are then populated with variables originating in empirical research. Conclusions are developed on which types are underpopulated and present potential for future research. I end with a set of methodological recommendations for future application of the model.
Yulia F. Lakhvich
Full Text Available To become a mother … To be a mother … What does it mean for a woman? And what else changes her life so irreversibly, allows to see the world in a different way and discovers new, earlier unknown features? Probably, nothing does. However, there is also a question how a woman bearing a child and carrying out motherhood responsibilities and a woman who has not given life to a child, but carrying out the same responsibilities, goes through the process of motherhood. It is one of the questions that was studied in a comparative research of the adaptation process in the Belarusian adoptive and biological families in case of a child appearing in the family. The study involved 64 adoptive and 62 biological mothers.
Colitti, Lorenzo; Gunderson, Steinar H.; Kline, Erik; Refice, Tiziana
As IPv4 address space approaches exhaustion, large networks are deploying IPv6 or preparing for deployment. However, there is little data available about the quantity and quality of IPv6 connectivity. We describe a methodology to measure IPv6 adoption from the perspective of a Web site operator and to evaluate the impact that adding IPv6 to a Web site will have on its users. We apply our methodology to the Google Web site and present results collected over the last year. Our data show that IPv6 adoption, while growing significantly, is still low, varies considerably by country, and is heavily influenced by a small number of large deployments. We find that native IPv6 latency is comparable to IPv4 and provide statistics on IPv6 transition mechanisms used.
National security, poverty alleviation, and refugees are global issues which all urgently need to be addressed. However, no major issue will be resolved until the population problem is solved. Humankind needs to find a way to live in harmony with the earth and its natural environment. The 1994 International Conference on Population and Development (ICPD) adopted a program of action outlining practical measures to be taken with regard to population and development. The concepts of reproductive health and women's empowerment were also adopted. The ICPD was in many ways an historic conference which set the future direction for the issues of population and development. The conference program of action must be fully implemented to ensure a healthy future for humankind and the earth. Elected officials must do their best to ensure that the ICPD program of action is successfully implemented.
Adriana Florina POPA
Full Text Available Accounting globalization follows the transformation of the accounting system into an economic and financial model, able to inform more correctly and rapidly the users of the accounting information, amongst which the investors and the creditors are clearly delimited. Within this context, the need of a harmonized and well oriented accounting system has become imperative. The adoption of a set of international accounting standards in Europe is intended to provide uniform and high quality financial information on the financial markets which would consolidate the global market efficiency, reducing the cost of capital accessing for European companies. There are numerous opinions according to which the IFRS adoption could be an element of abolishing the discrepancies between the accounting systems, offering at the same time a high level of transparency of the financial information. Our objective is to analyze the opportunity of implementing the IAS/IFRS referential by the Romanian companies, as well as their instant reaction within this context.
Gimpel, Gregory; Sudzina, Frantisek; Petrovcikova, Katarina
Despite the rapid global diffusion of the smartphone, some countries have experienced much slower uptake of the technology. The low smartphone penetration within Slovakia provides the opportunity to explore what drives smartphone use in late majority countries. Slovakia is a central European nation...... and part of the Eurozone. It has advanced telecommunications infrastructure and is subject to the same telecommunications regulations as other EU members. While neighbours have high smartphone penetration, Slovakia is a late majority adopter. This study uses Triandis’ theory of interpersonal behavior...... to investigate the question: What drives the use of smartphones in late majority countries? By studying the differences between current and potential smartphone users, the study revisits Karahanna et al.’s research question: Do potential adopters and users of IT hold the same behavioral and normative beliefs...
Stenager, Egon; Stenager, E N; Knudsen, Lone
In a cross-sectional study of 117 randomly selected patients (52 men, 65 women) with definite multiple sclerosis, it was found that 76 percent were married or cohabitant, 8 percent divorced. Social contacts remained unchanged for 70 percent, but outgoing social contacts were reduced for 45 percent......, need for structural changes in home and need for pension became greater with increasing physical handicap. No significant differences between gender were found. It is concluded that patients and relatives are under increased social strain, when multiple sclerosis progresses to a moderate handicap...
de Vet, Emely; de Nooijer, Jascha; Oenema, Anke; de Vries, Nanne K; Brug, Johannes
To explore psychosocial correlates and predictors of stage transitions in the precaution adoption process model (PAPM) for fruit intake. A cohort completed three electronic questionnaires, at baseline (time 0), 35 days later (time 1), and another 32 days later (time 2). Secured Internet Web site. A cohort of 735 adults was formed from a random sample of an existing Internet panel. The mean age was 37.5 years, 51% were women, and 90% were of Dutch origin. Most respondents (48%) had a medium level of education. Precaution adoption process model stage, risk perception, perception of own fruit intake level, attitude, pros, cons, subjective norms, social support, modeling, self-efficacy, and fruit intake (assessed using a food frequency questionnaire). Cross-sectional differences in psychosocial variables and fruit intake across PAPM stages at baseline were analyzed using analysis of variance with Tukey multiple comparisons tests. Predictors of PAPM stage transitions between time 0 and time 1 and between time 1 and time 2 were analyzed using logistic regression analysis. Factors related to attitude and social influences may be important if one is to decide to act, whereas strong self-efficacy may also be required for acting on the decision to act. Although the results should be replicated in a larger and more representative sample, the PAPM seems a good framework for studying fruit intake.
Full Text Available The participation of industrial consumers in smart grid transition is important due to their consumption footprint, heavy energy use and complexity in the implementation of smart energy technologies. Active involvement of industrial consumers in the development of smart grid solutions is important to ensure the energy system transformation. Despite the importance of industrial consumers has been identified, the empirical studies on the smart grid still mainly address residential and commercial consumers. Therefore, based on four case studies with two industrial consumers, one energy consulting company and one electricity retailer, this paper investigates the factors that influence industrial consumers’ acceptance of smart grid solutions, and how the influential factors are relevant to the smart grid adoption phases. Eleven influential factors are identified that impact on four stages for industrial consumers’ adoption of smart grid solutions (inscription, translation, framing, and stabilization stages. The eleven influential factors are: awareness of multiple contexts, shared support, return-of-investment, ease of use, flexibility and dynamic pricing, liberalization and energy tariff structure, customer focus, solution integration, process improvement, service quality, and company’s green image.
Ciganek, Andrew Paul; (Dave) Haseman, William; Ramamurthy, K.
Organisations desire timeliness. Timeliness facilitates a better responsiveness to changes in an organisation's external environment to either attain or maintain competitiveness. Despite its importance, decision timeliness has not been explicitly examined. Decision timeliness is measured in this study as the time taken to commit to a decision. The research objective is to identify the drivers of decision timeliness in the context of adopting service-oriented architecture (SOA), an innovation for enterprise computing. A research model rooted in the technology-organisation-environment (TOE) framework is proposed and tested with data collected in a large-scale study. The research variables have been examined before in the context of adoption, but their applicability to the timeliness of innovation decision-making has not received much attention and their salience is unclear. The results support multiple hypothesised relationships, including the finding that a risk-oriented organisational culture as well as normative and coercive pressures accelerates decision timeliness. Top management support as well as the traditional innovation attributes (compatibility, relative advantage and complexity/ease-of-use) were not found to be significant when examining their influence on decision timeliness, which appears inconsistent with generally accepted knowledge and deserves further examination.
Veronica S. Lestari; Sitti Nurani Sirajuddin; Aslina Asnawi
The aim of this study was to know biosecurity adoption on beef cattle farms. This research was conducted for a month at Barru regency, South Sulawesi province, which famous asone of beef cattle breeding villages in Indonesia. Sample was choosed through random sampling. Total sampel was 30 beef cattle farmers. Data were collected through observation and interview. Biosecurity measures consisted of 35 indicators which was grouped into 4 namely: management practice, sanitation, disease and disea...
Christensen, Dane T [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Kemper, Emily [CLEAResult
This presentation on connected homes was presented at the 11th Rocky Mountain Utility Efficiency Exchange on September 28, 2017. The discussion covered the integration of energy efficiency measures and practices with Internet of Things (IoT) awareness and adoption of smart technologies and services via WiFi/ Bluetooth enabled home and office equipment. The presentation also describes the benefits to the home and business and benefits/challenges for the utility/implementer.
Full Text Available The purpose of the present paper is to analyze the export strategies adopted by Romanian small and medium sized enterprises, strategies based mainly on market niches. The paper applies a conceptual approach combined with analyses of statistics and secondary material and presents the importance of focusing on quality, branding strategies, innovation. The government has also an important role in supporting these companies to approach international markets.
Dill, Gerald M; Cajacob, Claire A; Padgette, Stephen R
Glyphosate-resistant crops (GRCs) were first introduced in the United States in soybeans in 1996. Adoption has been very rapid in soybeans and cotton since introduction and has grown significantly in maize in recent years. GRCs have grown to over 74 million hectares in five crop species in 13 countries. The intent of this paper is to update the hectares planted and the use patterns of GRC globally, and to discuss briefly future applications and uses of the technology. The largest land areas of GRCs are occupied by soybean (54.2 million ha), maize (13.2 million ha), cotton (5.1 million ha), canola (2.3 million ha) and alfalfa (0.1 million ha). Currently, the USA, Argentina, Brazil and Canada have the largest plantings of GRCs. Herbicide use patterns would indicate that over 50% of glyphosate-resistant (GR) maize hectares and 70% of GR cotton hectares receive alternative mode-of-action treatments, while approximately 25% of GR soybeans receive such a treatment in the USA. Alternative herbicide use is likely driven by both agronomic need and herbicide resistance limitations in certain GR crops such as current GR cotton. Tillage practices in the USA indicate that > 65% of GR maize hectares, 70% of GR cotton hectares and 50% of GR soybean hectares received some tillage in the production system. Tillage was likely used for multiple purposes ranging from seed-bed preparation to weed management. GRCs represent one of the more rapidly adopted weed management technologies in recent history. Current use patterns would indicate that GRCs will likely continue to be a popular weed management choice that may also include the use of other herbicides to complement glyphosate. Stacking with other biotechnology traits will also give farmers the benefits and convenience of multiple pest control and quality trait technologies within a single seed. Copyright (c) 2007 Society of Chemical Industry.
Stenager, E; Knudsen, L; Jensen, K
In a cross-sectional investigation of 116 patients with multiple sclerosis, the social and sparetime activities of the patient were assessed by both patient and his/her family. The assessments were correlated to physical disability which showed that particularly those who were moderately disabled...
The results of the use of melphalan in 52 patients with multiple myeloma have been analysed. The median survival of the whole group of patients was 30 months, and of those w:th renal insufficiency only 12,5 months. Bence-lones proteinuria was also a poor prognostic finding,. but only because of its association with renal ...
Plummer, Nancy; Michael, Nancy, Ed.
This module on multiple sclerosis is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. The module goal and objectives are then…
Stenager, E; Jensen, K
Forty-two (12%) of a total of 366 patients with multiple sclerosis (MS) had psychiatric admissions. Of these, 34 (81%) had their first psychiatric admission in conjunction with or after the onset of MS. Classification by psychiatric diagnosis showed that there was a significant positive correlati...
Stenager, E; Jensen, K
An investigation on the correlation between ability to read TV subtitles and the duration of visual evoked potential (VEP) latency in 14 patients with definite multiple sclerosis (MS), indicated that VEP latency in patients unable to read the TV subtitles was significantly delayed in comparison...
Perry, Cassandra L; Henry, Martha J
Genetic counselors and other health professionals may encounter adoption during any counseling session. They must be skilled in using appropriate language and understand how to approach and discuss this topic with clients. A thorough knowledge of adoption as an option for clients facing a prenatal or postnatal diagnosis is necessary when presenting individuals with non-biased information needed for informed decision-making. However, three preliminary studies have demonstrated an absence of graduate education and lack of a professional knowledge base regarding this option (Mates 2008; Oksala 2007; Perry 2003). We discuss the impact of medical professionals' preconceptions on client decision-making, increasing early identification of fetal anomalies, deficiency of adoption knowledge and resources, and the resulting need for genetic counselors and other health professionals to develop their skills in discussing adoption with clients.
Adoção da estratégia modular por empresas do setor automotivo e as implicações relativas à transferência de atividades no desenvolvimento de produto: um estudo de casos múltiplos Adoption of the modular strategy for companies in the automotive sector and the implications regarding the transfer of new product development activities: a multiple case study
Full Text Available A modularidade aplicada ao desenvolvimento de novos produtos, acompanhada da terceirização das atividades de produção, tem sido uma estratégia adotada pelas montadoras automotivas. O desenvolvimento de produto no contexto da estratégia modular implica em uma redistribuição das atividades inerentes a este processo, baseando-se na decomposição e na divisão das tarefas entre as montadoras e seus fornecedores. Nesse contexto, este estudo investiga as implicações da estratégia modular no processo de capacitação e na transferência de atividades de desenvolvimento de produto entre os fornecedores de primeiro e segundo nível da cadeia de suprimentos automotiva. O trabalho é desenvolvido por meio de uma abordagem metodológica de múltiplos casos. As empresas investigadas foram posicionadas em níveis distintos de competências modulares - "embrionária", "em desenvolvimento" e "madura"-, de acordo com as evidências empíricas levantadas. Evidenciou-se uma relação entre o estágio de maturidade de competências e as principais atividades de desenvolvimento de produto.Modularity applied to new product development together with the externalisation of production has been a strategy adopted by automotive companies. New product development in the context of modular strategy implies a redistribution of inherent activities of production. This is based on a work division among assemblers and their suppliers. In this context, this study investigates the implications of modular strategies in the process of transferring value-added activities in new product development between first and second tier suppliers. The study is developed based on a multiple case study approach. The investigated companies were positioned in distinct levels of modular competencies ('embrionary', 'in development', and 'mature', according to empirical evidence. A relationship between the stage of maturity and major new product development practices was identified.
Wilbarger, Julia; Gunnar, Megan; Schneider, Mary; Pollak, Seth
Background/Methods: Sensory processing capacities of 8-12-year-old internationally adopted (IA) children who experienced prolonged institutional care (greater than 12 months with 75% of pre-adoption lives in institutional care) prior to adoption into family environments (PI) were compared to a group of IA children who were adopted early (less than…
... adoption. 222.34 Section 222.34 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE... equitable adoption. In many States, where a legal adoption proceeding was defective under State law or where a contemplated legal adoption was not completed, a claimant may be considered to be an equitably...
... 7 Agriculture 12 2010-01-01 2010-01-01 false Adoption of an EA. 1794.71 Section 1794.71... AGRICULTURE (CONTINUED) ENVIRONMENTAL POLICIES AND PROCEDURES Adoption of Environmental Documents § 1794.71 Adoption of an EA. RUS may adopt a Federal EA or EIS or a portion thereof as its EA. RUS shall make the EA...
The study analysed the determinants of adoption of improved cassava varieties by farmers in Umunneochi LGA of Abia State, estimated the level of adoption of the improved varieties and compared the yield and income among adopters and non-adopters of improved cassava varieties. A multistage sampling technique was ...
Smith, Ellen M.
Domestic transracial adoption has sparked more controversy than any other type of adoption. For the purposes of this study domestic transracial adoption is defined as European American parents adopting African American children. Many of the studies completed are contradictory and fail to control for variables that affect the outcome such as age of…
Grow, Lucille J.; Shapiro, Deborah
This study was designed to provide information about the outcomes of transracial adoptions in response to a growing trend among adoption agencies to place children across racial lines. The study focused on 125 adopted black children and their white adoptive families. The children ranged in age from 5 to 19 years (median of age=8.8 years) and had…
National Committee for Adoption, Inc., Washington, DC.
This document is designed to fill major information voids in the field of adoption and to provide prospective adoptive parents with reliable data on which to base decisions. The factbook contains four major types of new information: (1) a frank discussion of the issues concerning adoption -- including costs; tax regulations; transracial adoption;…
Straub, Evan T.
How and why individuals adopt innovations has motivated a great deal of research. This article examines individuals' computing adoption processes through the lenses of three adoption theories: Rogers's innovation diffusion theory, the Concerns-Based Adoption Model, the Technology Acceptance Model, and the United Theory of Acceptance and Use of…
Cecilia Serena ePace
Full Text Available Introduction. Recent literature has shown that the good outcome of adoption would mostly depend on the quality of adoptive parenting, which is strongly associated with the security of parental internal working models (IWMs of attachment. Specifically, attachment states-of-mind of adoptive mothers classified as free and autonomous and without lack of resolution of loss or trauma could represent a good protective factor for adopted children previously maltreated and neglected. While most research on adoptive families has focused on pre-school and school-aged children, the aim of this study was to assess the concordance of IWMs of attachment in adoptive dyads during adolescence.Method. Our pilot-study involved 76 participants: 30 adoptive mothers (mean age=51.5±4.3, and their 46 late-adopted adolescents (mean age = 13.9 ± 1.6, who were all aged four to nine years old at time of adoption (M = 6.3 ± 1.5. Attachment representations of adopted adolescents were assessed by the Friend and Family Interview (FFI, while adoptive mothers’ state-of-mind with respect to attachment was classified by the Adult Attachment Interview (AAI. Adolescents’ verbal intelligence was controlled.Results. Late-adopted adolescents were classified as follows: 67% secure, 26% dismissing and 7% preoccupied in the FFI, while their adoptive mothers’ AAI classifications were 70% free-autonomous, 7% dismissing, and 23% unresolved. We found a significant concordance of 70% (32 dyads between the secure-insecure FFI and AAI classifications. Specifically adoptive mothers with high coherence of transcript and low unresolved loss tend to have late-adopted children with high secure attachment, even if the adolescents’ verbal intelligence made a significant contribution to this prediction.Discussion. Our results provides an empirical contribution to the literature concerning the concordance of attachment in adoptive dyads, highlighting the beneficial impact of highly coherent
Grotevant, Harold D; McDermott, Jennifer M
Children join adoptive families through domestic adoption from the public child welfare system, infant adoption through private agencies, and international adoption. Each pathway presents distinctive developmental opportunities and challenges. Adopted children are at higher risk than the general population for problems with adaptation, especially externalizing, internalizing, and attention problems. This review moves beyond the field's emphasis on adoptee-nonadoptee differences to highlight biological and social processes that affect adaptation of adoptees across time. The experience of stress, whether prenatal, postnatal/preadoption, or during the adoption transition, can have significant impacts on the developing neuroendocrine system. These effects can contribute to problems with physical growth, brain development, and sleep, activating cascading effects on social, emotional, and cognitive development. Family processes involving contact between adoptive and birth family members, co-parenting in gay and lesbian adoptive families, and racial socialization in transracially adoptive families affect social development of adopted children into adulthood.
An important channel through which globalization affects poverty is introducing new technologies to developing countries. Adoption of new technologies can be hindered by uncertainties about their efficiency. This paper studies the role of information exchange between adopters and others about a new technology and about each other’s likelihood of adoption. We show that information about the technology can reduce adoption at the beginning of the diffusion process and increase adoption later. In...
My thesis, "Love and Violence in Transracial/national Adoption," examines a New York Times special transracial adoption blog series, "Relative Choices," to critically interrogate how love and violence operate in adoption discourse. In doing so, it explores two main questions: How have transracial/national adoptions been posited in the past and how does that inform current articulations? Second, how would a global/historical framework help rethink transracial/national adoptions beyond one base...
Dias, Paulo Cezar; Gramstrup, Erik Frederico
With the modification of the family concept in human history, now considered the site of important value, aimed at personal fulfillment of its members, in line with the Federal Constitution of 1988 was enshrined in the principles of human dignity, affection, equal affiliations and plurality of family entities, recognizing the socio-affective parenting, founded in the state of emotional child, and biological, originally from consanguinity ties, arises multiple parenting in response to the full...
Vreeman, Daniel J; Chiaravalloti, Maria Teresa; Hook, John; McDonald, Clement J
Interoperable health information exchange depends on adoption of terminology standards, but international use of such standards can be challenging because of language differences between local concept names and the standard terminology. To address this important barrier, we describe the evolution of an efficient process for constructing translations of LOINC terms names, the foreign language functions in RELMA, and the current state of translations in LOINC. We also present the development of the Italian translation to illustrate how translation is enabling adoption in international contexts. We built a tool that finds the unique list of LOINC Parts that make up a given set of LOINC terms. This list enables translation of smaller pieces like the core component "hepatitis c virus" separately from all the suffixes that could appear with it, such "Ab.IgG", "DNA", and "RNA". We built another tool that generates a translation of a full LOINC name from all of these atomic pieces. As of version 2.36 (June 2011), LOINC terms have been translated into nine languages from 15 linguistic variants other than its native English. The five largest linguistic variants have all used the Part-based translation mechanism. However, even with efficient tools and processes, translation of standard terminology is a complex undertaking. Two of the prominent linguistic challenges that translators have faced include: the approach to handling acronyms and abbreviations, and the differences in linguistic syntax (e.g. word order) between languages. LOINC's open and customizable approach has enabled many different groups to create translations that met their needs and matched their resources. Distributing the standard and its many language translations at no cost worldwide accelerates LOINC adoption globally, and is an important enabler of interoperable health information exchange. Copyright © 2012 Elsevier Inc. All rights reserved.
Vreeman, Daniel J.; Chiaravalloti, Maria Teresa; Hook, John; McDonald, Clement J.
Interoperable health information exchange depends on adoption of terminology standards, but international use of such standards can be challenging because of language differences between local concept names and the standard terminology. To address this important barrier, we describe the evolution of an efficient process for constructing translations of LOINC terms names, the foreign language functions in RELMA, and the current state of translations in LOINC. We also present the development of the Italian translation to illustrate how translation is enabling adoption in international contexts. We built a tool that finds the unique list of LOINC Parts that make up a given set of LOINC terms. This list enables translation of smaller pieces like the core component “hepatitis c virus” separately from all the suffixes that could appear with it, such “Ab.IgG”, “DNA”, and “RNA”. We built another tool that generates a translation of a full LOINC name from all of these atomic pieces. As of version 2.36 (June 2011), LOINC terms have been translated into 9 languages from 15 linguistic variants other than its native English. The five largest linguistic variants have all used the Part-based translation mechanism. However, even with efficient tools and processes, translation of standard terminology is a complex undertaking. Two of the prominent linguistic challenges that translators have faced include: the approach to handling acronyms and abbreviations, and the differences in linguistic syntax (e.g. word order) between languages. LOINC’s open and customizable approach has enabled many different groups to create translations that met their needs and matched their resources. Distributing the standard and its many language translations at no cost worldwide accelerates LOINC adoption globally, and is an important enabler of interoperable health information exchange PMID:22285984
Thompson, Alan J; Baranzini, Sergio E; Geurts, Jeroen; Hemmer, Bernhard; Ciccarelli, Olga
Multiple sclerosis continues to be a challenging and disabling condition but there is now greater understanding of the underlying genetic and environmental factors that drive the condition, including low vitamin D levels, cigarette smoking, and obesity. Early and accurate diagnosis is crucial and is supported by diagnostic criteria, incorporating imaging and spinal fluid abnormalities for those presenting with a clinically isolated syndrome. Importantly, there is an extensive therapeutic armamentarium, both oral and by infusion, for those with the relapsing remitting form of the disease. Careful consideration is required when choosing the correct treatment, balancing the side-effect profile with efficacy and escalating as clinically appropriate. This move towards more personalised medicine is supported by a clinical guideline published in 2018. Finally, a comprehensive management programme is strongly recommended for all patients with multiple sclerosis, enhancing health-related quality of life through advocating wellness, addressing aggravating factors, and managing comorbidities. The greatest remaining challenge for multiple sclerosis is the development of treatments incorporating neuroprotection and remyelination to treat and ultimately prevent the disabling, progressive forms of the condition. Copyright © 2018 Elsevier Ltd. All rights reserved.
Sadashima, Hiromichi; Kusaka, Hirofumi; Imai, Terukuni; Takahashi, Ryosuke; Matsumoto, Sadayuki; Yamamoto, Toru; Yamasaki, Masahiro; Maya, Kiyomi
Eleven patients with a definite diagnosis of multiple sclerosis were examined in terms of correlations between the clinical features and the results of cranial computed tomography (CT), and magnetic resonance imaging (MRI). Results: In 5 of the 11 patients, both CT and MRI demonstrated lesions consistent with a finding of multiple sclerosis. In 3 patients, only MRI demonstrated lesions. In the remaining 3 patients, neither CT nor MRI revealed any lesion in the brain. All 5 patients who showed abnormal findings on both CT and MRI had clinical signs either of cerebral or brainstem - cerebellar lesions. On the other hand, two of the 3 patients with normal CT and MRI findings had optic-nerve and spinal-cord signs. Therefore, our results suggested relatively good correlations between the clinical features, CT, and MRI. MRI revealed cerebral lesions in two of the four patients with clinical signs of only optic-nerve and spinal-cord lesions. MRI demonstrated sclerotic lesions in 3 of the 6 patients whose plaques were not detected by CT. In conclusion, MRI proved to be more helpful in the demonstration of lesions attributable to chronic multiple sclerosis. (author)
Zailani, Suhaiza; Govindan, Kannan; Iranmanesh, Mohammad
generators of industrial waste that affect the quality of the natural environment. This study aims to investigate the determinants of green innovation adoption and its effect on firm performance. Data were gathered by surveying 153 firms in the Malaysian automotive supply chain industry. Data were analyzed...... using the partial least squares technique. Environmental regulations, market demand, and firm internal initiatives have a positive effect on green innovation initiatives (GII), while GIIs have a positive effect on the three categories of sustainable performance (i.e., environmental, social, and economic...
Neumann, Paul E
Exceptions to the anatomical nomenclature rule that names must be in proper Latin include a few terms that contain borrowed Greek adjectives that are not declined like Latin words. Adoption of these adjectives into Latin would change about a half-dozen terms, e.g., vena azyga, vena hemiazyga, and fascia darta. The anatomical nomenclature rules apply only to the Latin terms, so there is no requirement to alter the way azygos, hemiazygos, and dartos are used in equivalent terms in other languages. Clin. Anat. 30:450-451, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.
Full Text Available This paper presents managerial attempts at implementing telehealthcare. Our longitudinal, ethnographic case studies document both successful and failed implementations across five health and social care organisations in England. We draw on theories of organisational identity, sensemaking and sensegiving to highlight how managerial organisational identities can inhibit the uptake of digital health technologies. Managers who strongly identified with their current role at work felt threatened by the intended change; a telehealthcare mode of care delivery. When a strongly identified workforce agrees with this assessment, managerial and employee sensemaking and sensegiving coalesce, forming a united front of resistance that prevents further adoption of the innovation.
Nelson-Erichsen, Jean; Erichsen, Heino R.
Many potential adoptive parents seeking international adoption find the process to be extremely complex. This guide details the international adoption process, including organizing a home study and fulfilling state requirements as well as selecting a country from which to adopt, working through emigration and immigration agencies, and traveling…
Shelley-Sireci, Lynn M.; Ciano-Boyce, Claudia
Two studies were conducted to evaluate newly developed measures of attitudes about adoption. The Attitudes toward Adoption Scale was developed, based on research literature, to investigate the attitudes of people with and without experience with adoption toward adoption. Eighty-six college students completed this scale and made open-ended comments…
Chapman, Nicola H; Lazar, Steven P; Fry, Margaret; Lassere, Marissa N; Chong, Beng H
Venous Thromboembolism (VTE) is a cause of hospital mortality and managing its morbidity is associated with significant expenditure. Uptake of evidenced based guideline recommendations intended to prevent VTE in hospital settings is sub-optimal. This study was conducted to explore clinicians' attitudes and the clinical environment in which they work to understand their reluctance to adopt VTE prophylaxis guidelines. Between February and November 2009, 40 hospital employed doctors from 2 Australian metropolitan hospitals were interviewed in depth. Qualitative data were analysed according to thematic methodology. Analysis of interviews revealed that barriers to evidence based practice include i) the fragmented system of care delivery where multiple members of teams and multiple teams are responsible for each patient's care, and in the case of VTE, where everyone shares responsibility and no-one in particular is responsible; ii) the culture of practice where team practice is tailored to that of the team head, and where medicine is considered an 'art' in which guidelines should be adapted to each patient rather than applied universally. Interviewees recommend clear allocation of responsibility and reminders to counteract VTE risk assessment being overlooked. Senior clinicians are the key enablers for practice change. They will need to be convinced that guideline compliance adds value to their patient care. Then with the support of systems in the organisation designed to minimize the effects of care fragmentation, they will drive practice changes in their teams. We believe that evidence based practice is only possible with a coordinated program that addresses individual, cultural and organisational constraints.
Schulman, Joshua M; Oh, Dennis H; Sanborn, J Zachary; Pincus, Laura; McCalmont, Timothy H; Cho, Raymond J
Multiple hereditary infundibulocystic basal cell carcinoma syndrome (MHIBCC) is a rare genodermatosis in which numerous indolent, well-differentiated basal cell carcinomas develop primarily on the face and genitals, without other features characteristic of basal cell nevus syndrome. The cause is unknown. The purpose of the study was to identify a genetic basis for the syndrome and a mechanism by which the associated tumors develop. Whole-exome sequencing of 5 tumors and a normal buccal mucosal sample from a patient with MHIBCC was performed. A conserved splice-site mutation in 1 copy of the suppressor of fused gene (SUFU) was identified in all tumor and normal tissue samples. Additional distinct deletions of the trans SUFU allele were identified in all tumor samples, none of which were present in the normal sample. A germline SUFU mutation was present in a patient with MHIBCC, and additional acquired SUFU mutations underlie the development of infundibulocystic basal cell carcinomas. The downstream location of the SUFU gene within the sonic hedgehog pathway may explain why its loss is associated with relatively well-differentiated tumors and suggests that MHIBCC will not respond to therapeutic strategies, such as smoothened inhibitors, that target upstream components of this pathway.
Nurkaliza Bt Khalid
Full Text Available Electronic materials such as e-book have become increasingly accepted as learning tools in the classroom nowadays. This study investigated the relationships between the big five personality traits: conscientiousness, agreeableness, neuroticism, openness to experience, and extroversion with e-book adoption among college students. Pearson Product Moment Correlation and Multiple Regressions were conducted to analyze the data. Results revealed statistically significant relationships between the personality traits (conscientiousness, agreeableness, openness to experience, extraversion and e-book adoption. Implications of the findings are also discussed.
Full Text Available This paper explores issues and challenges in the adoption of e-learning in hospitality education, with special reference to Singapore. Hospitality being a ‘high-touch’ profession and many hospitality related skills being largely intangible, there has been significant industry resistance in technology adoption. There has been concerns from multiple stakeholder groups as to how effectively can technologies compensate for the loss of social context of traditional hands-on learning. However, in Singapore, some polytechnic based schools have practically demonstrated the ways by which technology could be meaningfully integrated into hospitality education.
Afzaal H. Seyal
Full Text Available The study examines the 250 CEOs’ leadership style in adoption of electronic commerce (EC among Bruneian SMEs. The study uses Bolman and Deals’ instrument to measure the leadership frames and found that majority (70% of the leadersare practicing all four frames and considered as effective leaders. Both human and symbolic (paired frames of leadership remains dominant.In addition, structural, human resource and symbolic frames are ranked highest among the multiple (three frames used. However, paired leadership frames (human and symbolic were found to be significan't predictor of EC adoption among Bruneian SMEs. Based upon the analysis and conclusion some recommendations were made for the relevant authorities.
Baker, Michael K; Kennedy, David J; Bohle, Philip L; Campbell, Deena; Wiltshire, James H; Singh, Maria A Fiatarone
Progressive resistance training (PRT) counteracts sarcopenia and has been demonstrated to improve physical function and quality of life in older adults. Despite the clear benefits of PRT, participation remains low. The core self-evaluation (CSE) construct is theoretically antecedent to four personality traits: locus of control, self-esteem, neuroticism (emotional stability), and generalized self-efficacy. We have examined the association of CSE with exercise adoption among older adults invited to participate in a PRT trial. We hypothesized that CSE would positively predict adoption of PRT. All residents of two retirement communities were invited to complete questionnaires with items on demographics, physical activity, CSE, and general health. Following completion of questionnaires, residents were invited to take part in an on-site, 10-week randomized controlled trial of a PRT-based exercise trial. Thirty-eight of 358 residents (63.2% women; 76.6±6.1 year; range 58-92) enrolled and 118 residents completed the questionnaires. Multiple regression analysis predicting PRT adoption indicated that the demographic variables accounted for 38% of the variance. Inclusion of CSE (β=.405) accounted for an additional 10% of the variance in PRT adoption. CSE was predictive of PRT adoption in this cohort, adding significantly to the predictive efficacy of known demographic predictors. This is the first study to show that CSE may influence adoption of PRT in any cohort. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Sierzchula, William; Bakker, Sjoerd; Maat, Kees; Wee, Bert van
Electric vehicles represent an innovation with the potential to lower greenhouse gas emissions and help mitigate the causes of climate change. However, externalities including the appropriability of knowledge and pollution abatement result in societal/economic benefits that are not incorporated in electric vehicle prices. In order to address resulting market failures, governments have employed a number of policies. We seek to determine the relationship of one such policy instrument (consumer financial incentives) to electric vehicle adoption. Based on existing literature, we identified several additional socio-economic factors that are expected to be influential in determining electric vehicle adoption rates. Using multiple linear regression analysis, we examined the relationship between those variables and 30 national electric vehicle market shares for the year 2012. The model found financial incentives, charging infrastructure, and local presence of production facilities to be significant and positively correlated to a country's electric vehicle market share. Results suggest that of those factors, charging infrastructure was most strongly related to electric vehicle adoption. However, descriptive analysis suggests that neither financial incentives nor charging infrastructure ensure high electric vehicle adoption rates. - Highlights: • This research analyzes electric vehicle adoption of 30 countries in 2012. • Financial incentives and charging infrastructure were statistically significant factors. • Country-specific factors help to explain diversity in national adoption rates. • Socio-demographic variables e.g., income and education level were not significant
Andreia Carpes Dani
Full Text Available Several changes in the legislation governing accounting practices of construction sector companies boosted the internationalization of information on revenues of customer contracts in accounting. Brazil has stood out for early voluntary adoption of IFRS15 standard. Thus, the study aims to determine the relationship between the quality of accounting information and the early adoption of IFRS 15 by Brazilian construction companies listed on BM &FBovespa. The study is characterized as descriptive, conducted through document analysis and quantitative approach. The sample consists of 23 companies in the construction sector. Were analyzed quarterly data from 2013 to 2015. For the data analysis was made using multiple linear regression with panel data, on the basis of accounting information for quality measurement model of value relevance proposed by Ohlson (1995. The survey results suggest that early adoption of IFRS15 helps to reduce the bias of non-comparability and inconsistencies that could exist previously, due to the adoption of different criteria for accounting of revenues on construction contracts. In addition, organizations that voluntarily adopt the rule in an attempt to account for and properly recognize customer contracts revenue, have greater informational relevance and meet market expectations. Thus, it can be said that the early adoption of information on revenue from construction contracts have relevance to the capital market, impacting the stock price after the publication of financial reports.
Bergek, Anna; Mignon, Ingrid
The diffusion of renewable electricity technologies (RETs) has to speed up for countries to reach their, often ambitious, targets for renewable energy generation. This requires a large number of actors – including individuals, companies and other organizations – to adopt RETs. Policies will most likely be needed to induce adoption, but there is limited knowledge about what motivates RET adoption. The purpose of this paper is to complement and expand the available empirical evidence regarding motives to adopt RETs through a survey to over 600 RET adopters in Sweden. The main finding of the study is that there are many different motives to adopt RETs and that RET adopters are a heterogeneous group with regard to motives. Although environmental concerns, interest in the technology, access to an RE resource and prospects to generate economic revenues are important motives in general, adopters differ with regard to how large importance they attach to the same motive and each adopter can also have several different motives to adopt. There are also differences in motives between adopter categories (especially independent power producers vs. individuals and diversified companies) and between RETs (especially wind power vs. solar power). This implies that a variety of policy instruments might be needed to induce further adoption of a variety of RETs by a variety of adopter categories. - Highlights: • There are many different motives to adopt renewable electricity technologies (RETs). • Adopters attach different levels of importance to the same motive. • Adopters can have several different motives to adopt a particular RET. • Motives to adopt RETs differ between wind power, solar PV and small-scale hydro. • Motives to adopt RETs differ between IPPs, individuals and diversified companies.
Willis, Ken; Scarpa, Riccardo; Gilroy, Rose; Hamza, Neveen
Many countries are endeavouring to supply more of their energy from renewable resources. Such countries are also experiencing an aging population with a greater proportion of people aged ≥65 years. This demographic shift may reduce the uptake of renewable energy, if older person households are less inclined to accept change and adopt new technologies. This paper assesses whether such households have different behavioural responses to energy efficiency compared to the rest of society and investigates whether micro-generation renewable energy technologies are less likely to be adopted by these households. It uses conditional logit and mixed logit models to investigate the impact of age of household on primary heating adoption, and also to assess the impact of older households on the installation of discretionary micro-generation technologies (solar thermal, solar voltaic, and wind power) to supplement existing heating and lighting systems. Results indicate that primary heating choice is not affected but that older person households are less inclined to adopt micro-generation technologies. - Highlights: → Heterogeneity exists in decisions on micro-generation technology installation. → Older person households are less inclined to adopt micro-generation technologies. → Micro-generation technologies fail a social cost-benefit analysis test.
Electrically-powered aircraft can enable dramatic increases in efficiency and reliability, reduced emissions, and reduced noise as compared to today's combustion-powered aircraft. This paper describes a novel flight demonstration concept that will enable the benefits of electric propulsion, while keeping the extraordinary convenience and utility of common fuels available at today's airports. A critical gap in airborne electric propulsion research is addressed by accommodating adoption at the integrated aircraft-airport systems level, using a confluence of innovative but proven concepts and technologies in power generation and electricity storage that need to reside only on the airframe. Technical discriminators of this demonstrator concept include (1) a novel, high-efficiency power system that utilizes advanced solid oxide fuel cells originally developed for ultra-long-endurance aircraft, coupled with (2) a high-efficiency, high-power electric propulsion system selected from mature products to reduce technical risk, assembled into (3) a modern, high-performance demonstration platform to provide useful and compelling data, both for the targeted early adopters and the eventual commercial market.
Lamiraud, Karine; Lhuillery, Stephane
Despite the claim that technology has been one of the most important drivers of healthcare spending growth over the past decades, technology variables are rarely introduced explicitly in cost equations. Furthermore, technology is often considered exogenous. Using 1996-2007 panel data on Swiss geographical areas, we assessed the impact of technology availability on per capita healthcare spending covered by basic health insurance whilst controlling for the endogeneity of health technology availability variables. Our results suggest that medical research, patent intensity and the density of employees working in the medical device industry are influential factors for the adoption of technology and can be used as instruments for technology availability variables in the cost equation. These results are similar to previous findings: CT and PET scanner adoption is associated with increased healthcare spending, whilst increased availability of percutaneous transluminal coronary angioplasty facilities is associated with reductions in per capita spending. However, our results suggest that the magnitude of these relationships is much greater in absolute value than that suggested by previous studies that did not control for the possible endogeneity of the availability of technologies. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.
The Department of Energy (DOE), like other Federal agencies, is under increasing pressure to use information technology to improve efficiency in mission accomplishment as well as delivery of services to the public. Because users and systems have become interdependent, DOE has enterprise wide needs for common application architectures, communication networks, databases, security, and management capabilities. Users need open systems that provide interoperability of products and portability of people, data, and applications that are distributed throughout heterogeneous computing environments. The level of interoperability necessary requires the adoption of DOE wide standards, protocols, and best practices. The Department has developed an information architecture and a related standards adoption and retirement process to assist users in developing strategies and plans for acquiring information technology products and services based upon open systems standards that support application software interoperability, portability, and scalability. This set of Departmental Information Architecture standards represents guidance for achieving higher degrees of interoperability within the greater DOE community, business partners, and stakeholders. While these standards are not mandatory, particular and due consideration of their applications in contractual matters and use in technology implementations Department wide are goals of the Chief Information Officer.
Parris, Stuart; Cochrane, Gavin; Marjanovic, Sonja; Ling, Tom; Chataway, Joanna
Abstract The Department of Health and the Wellcome Trust, in co-operation with NHS England, asked RAND Europe to conduct a limited consultation with key stakeholders about the practicality of measures and incentives proposed as part of the NHS Accelerated Access Review (AAR), which aims to assess the pathways for the development, assessment, and adoption of innovative medicines and medical technology. Through a focused engagement exercise with key healthcare stakeholders this project explored the implications of selected interim AAR propositions and feasibility of implementation for key actors, in primary and secondary care as well as commissioners and academia. Specifically, the project investigated the feasibility of implementation of three specific propositions including: a new earmarked fund to encourage AHSNs and other key innovation actors to re-design systems to embrace innovation; mobilising the influence of clinical system leaders to champion change; and encouraging secondary care organisations to take on “innovation champion” roles linked to financial incentives and a new emphasis on accountable care organisations. Data was collected on the feasibility of the three AAR propositions from a workshop with AHSN CEOs and Commercial Directors and interviews with senior NHS staff in three AHSN regions (South West, University College London Partners, and North East, North Cumbria). The study concludes with reflections on the feasibility of each recommendation and identifies factors expected to facilitate or challenge their implementation, as well as considering the wider cross cutting issues that may influence the adoption and diffusion of innovation in the NHS. PMID:28083436
A supplement to the national marriage law was adopted by the 3rd session of the 4th People's Congress of the Ningxia Hui Autonomous Region which ended here today. The supplement includes a number of areas. With regard to marriage age it says no marriage shall be contracted before the man has reached 20 years of age and the woman 18. Both these figures are 2 years earlier than the national age specified by the national law. Legal marriage registration must not be replaced by religious ceremonies. With regard to Moslems, those who want religious wedding ceremonies can do so only after obtaining their marriage certificates. Freedom of marriage of widows is protected against any interference under any pretext. Marriage between Hui people and other nationalities, of their own free will, must not be interfered with. The nationality of any children shall be decided by the parents and children may reexamine the decision themselves when they grow up. The supplement has been adopted in accordance with the national marriage law's article 36 which says "The people's congresses and their standing committees in national autonomous areas may enact certain modifications or supplementary articles in keeping with the principles of this law and in conformity with the actual conditions prevailing among the minority nationalities of the locality in regard to marriage and family relations." The congress, held from June 9-June 14, reviewed the implementation of the Communist Party's policies on nationalities and development of economy, culture, education and public health. full text
Obringer, Emily; Walsh, Linda
Children who are adopted internationally have an increased risk of infectious diseases due to endemic conditions and variable access to preventive health care, such as vaccines, in their country of origin. Pediatricians and other providers who care for children should be familiar with the recommended screening for newly arrived international adoptees. Testing for gastrointestinal pathogens, tuberculosis, hepatitis, syphilis, and HIV should be routinely performed. Other endemic diseases and common skin infections may need to be assessed. Evaluation of the child's immunization record is also important, as nearly all international adoptees will require catch-up vaccines. The provider may also be asked to review medical records prior to adoption, provide travel advice, and ensure that parents and other close contacts are up-to-date on immunizations prior to the arrival of the newest family member. The pediatrician serves a unique role in facilitating the evaluation, treatment, and prevention of infectious diseases in international adoptees. [Pediatr Ann. 2017;46(2):e56-e60.]. Copyright 2017, SLACK Incorporated.
Full Text Available More and more organisations, from private to public sectors, are pursuing higher levels of customer satisfaction, loyalty and retention. With this intent, higher education institutions (HEI have adopted CRM – Customer Relationship Management. In order to analyse some of the interesting aspects of this phenomenon n, we conducted an action research in a European Institute. The main research question we answered is “how to adopt a CRM strategy in a Higher Education Institution?” Some of the main findings of this study are (1 even though HEI’s main customer is the student, there are others stakeholders that a CRM project must consider; (2 universities can use their internal resources to implement a CRM project successfully; and (3 using Agile software methodology is an effective way to define clearer, more objective and more assertive technical requirements which result in a CRM software that meet send user’s expectations and organizational strategic goals. These findings can help other HEIs
Stenager, Egon; Stenager, E N; Knudsen, Lone
In a cross-sectional study of 117 randomly selected patients (52 men, 65 women) with definite multiple sclerosis, it was found that 76 percent were married or cohabitant, 8 percent divorced. Social contacts remained unchanged for 70 percent, but outgoing social contacts were reduced for 45 percent....... Ninety-five percent lived in own house or flat and 70 percent received disablement pension. More than half of the patients (56.4 percent) were dependent on help from close relatives, most frequently spouse. The need for help, the risk of divorce, loss of contact with relatives, difficulty in going out...
Rushton, Alan; Grant, Margaret; Feast, Julia; Simmonds, John
While studies of ex-orphanage care show adverse effects on development, the longer-term impact on mid-life psychosocial functioning and physical health has not been established. Orphanage records provided baseline data on a sample of 100 Hong Kong Chinese girls who were subsequently adopted into the UK. A mid-life follow-up using standardised questionnaires and face-to-face interviews assessed current circumstances, life satisfaction and mental and physical health outcomes. Comparisons were made with age-matched UK-born adopted and nonadopted women. Half the group spent between 1 and 2 years in orphanages, average age at adoptive placement was 23 months and 72% participated in the follow-up. Despite this poor early start, mid-life outcomes were commensurate with the comparison groups in terms of mental and physical health measures. Serious psychiatric and social difficulties were largely absent. Although the timing and extent of exposure to orphanage care did not influence outcome, participants' reports of poorer quality adoptive family experience and a negative view of their adoption were significantly associated with poorer mental health outcomes (difference in means = 0.76, 95% CI 1.33-0.19, p = .01; difference in means = 1.2, 95% CI 0.68-1.73, p = .01, respectively). Moderately depriving orphanage care did not predict enduring adverse consequences in mid-life but subsequent poor adoption experience was associated with outcome. © 2013 The Authors. Journal of Child Psychology and Psychiatry © 2013 Association for Child and Adolescent Mental Health.
Abe, Masahiro; Miki, Hirokazu; Nakamura, Shingen
Owing to the positive clinical benefits obtained with new agents, complete remission (CR) can be used as a surrogate for overall survival, and should be achieved. Although multiple myeloma is a heterogeneous disease in terms of myeloma cell- and patient-related risk factors, patients should receive the most effective combination therapy based on proteasome inhibitors and/or immunomodulatory drugs (IMiDs) as backbone medication irrespective of the risks encountered in the setting of induction therapy ("one-size-fits-all" therapy), followed by consolidation/maintenance therapy to achieve CR with the ultimate goal of extended survival. Myeloma-defining biomarkers have been established to identify high-risk smoldering myeloma requiring treatment. The development of salvage treatments yielding better outcomes for relapsed/refractory myeloma is urgently needed. Upcoming novel molecular targeting agents with different modes of action and immunotherapeutic agents will be integrated into myeloma treatment regimens with a great therapeutic impact, and further evolution of the treatment paradigm for multiple myeloma is eagerly anticipated.
The Theory of Inflation, namely, that at some point the entropy content of the universe was greatly increased, has much promise. It may solve the puzzles of homogeneity and the creation of structure. However, no particle physics model has yet been found that can successfully drive inflation. The difficulty in satisfying the constraint that the isotropy of the microwave background places on the effective potential of prospective models is immense. In this work we have codified the requirements of such models in a most general form. We have carefully calculated the amounts of inflation the various problems of the Standard Model need for their solution. We have derived a completely model independent upper bond on the inflationary Hubble parameter. We have developed a general notation with which to probe the possibilities of Multiple Inflation. We have shown that only in very unlikely circumstances will any evidence of an earlier inflation, survive the de Sitter period of its successor. In particular, it is demonstrated that it is most unlikely that two bouts of inflation will yield high amplitudes of density perturbations on small scales and low amplitudes on large. We conclude that, while multiple inflation will be of great theoretical interest, it is unlikely to have any observational impact
Full Text Available Harnessing the immune system to recognize and destroy tumor cells has been the central goal of anti-cancer immunotherapy. In recent years, there has been an increased interest in optimizing this technology in order to make it a clinically feasible treatment. One of the main treatment modalities within cancer immunotherapy has been adoptive T cell therapy (ACT. Using this approach, tumor-specific cytotoxic T cells are infused into cancer patients with the goal of recognizing, targeting, and destroying tumor cells. In the current review, we revisit some of the major successes of ACT, the major hurdles that have been overcome to optimize ACT, the remaining challenges, and future approaches to make ACT widely available.
For about a decade, the electric utility industry has deemphasized the role of marketing and stressed instead management of natural resources and conservation. This has caused a lack of two-way commnication between customers and utilities, and has encouraged growing customer dissatisfaction, resentment, and disillusionment. Although these problems have been recognized for several years, it's only during the past 1 1/2 to 2 years that they have been looked into in depth. Now, under the auspices of the Edison Electric Institute, a two-pronged national marketing strategy for investor-owned utilities has been developed and adopted--one that will accommodate company situations that may be significantly dissimilar in character and regulatory climate.
Su-may Sheih Chen
Full Text Available To enhance the quality of library and information service, libraries have borrowed from business theory and practice in planning and evaluating library services. However, an area of business theory that has received relatively little attention in library science is organizational innovation. Reports in the business literature provide evidence that innovation is essential for both development and survival. In increasingly unstable times of rapidly changing information technology, libraries must use the literature of innovation as well as that of planning and evaluation to shape better libraries. This paper explores key issues related to innovation in libraries including the nature, the barriers, and the ways to adopt and implement innovative strategies successfully. [Article content in Chinese
Wood, Lloyd; Ivancic, William; da Silva Curiel, Alex; Jackson, Chris; Stewart, Dave; Shell, Dave; Hodgson, Dave
After a year of testing and demonstrating a Cisco mobile access router intended for terrestrial use onboard the low-Earth-orbiting UK-DMC satellite as part of a larger merged ground/space IP-based internetwork, we reflect on and discuss the benefits and drawbacks of integration and standards reuse for small satellite missions. Benefits include ease of operation and the ability to leverage existing systems and infrastructure designed for general use, as well as reuse of existing, known, and well-understood security and operational models. Drawbacks include cases where integration work was needed to bridge the gaps in assumptions between different systems, and where performance considerations outweighed the benefits of reuse of pre-existing file transfer protocols. We find similarities with the terrestrial IP networks whose technologies we have adopted and also some significant differences in operational models and assumptions that must be considered.
Yildiz, Ozkan; Demirörs, Onur
In this study, we investigated the adoptability of software quality measures for healthcare process measurement. Quality measures of ISO/IEC 9126 are redefined from a process perspective to build a generic healthcare process quality measurement model. Case study research method is used, and the model is applied to a public hospital's Entry to Care process. After the application, weak and strong aspects of the process can be easily observed. Access audibility, fault removal, completeness of documentation, and machine utilization are weak aspects and these aspects are the candidates for process improvement. On the other hand, functional completeness, fault ratio, input validity checking, response time, and throughput time are the strong aspects of the process.
Full Text Available This article introduces the opportunities for innovation adoption in art galleries. It provides systematised information on innovation processes and innovations used in business models of art galleries. The empirical research conducted has revealed the attitude of art galleries towards innovations, as well as the benefits and opportunities to realise them. The first part of the article distinguishes the stages of innovation process and management. The following part describes the factors that influence the management of innovation process. The final part of the article analyses the application of innovations for the improvement of a business model, with Business Model Canvas by Alexander Osterwalder and Yves Pigneur selected as the starting point for analysis and, finally, the outcomes of empirical research are provided.
Alexander, G Caleb; O'Connor, Alec B; Stafford, Randall S
The adoption and use of a new drug would ideally be guided by its innovation and cost-effectiveness. However, information about the relative efficacy and safety of a drug is typically incomplete even well after market entry, and various other forces create a marketplace in which most new drugs are little better than their older counterparts. Five proposed mechanisms are considered for promoting innovation and reducing the use of therapies ultimately found to offer poor value or have unacceptable risks. These changes range from increasing the evidence required for U.S. Food and Drug Administration approval to modifying the structure of drug reimbursement. Despite the challenges of policy implementation, the United States has a long history of successfully improving the societal value and safe use of prescription medicines.
Full Text Available The economic conditions and market competition create pressures on companies to adopt new technologies that can provide more efficient information and can support decision-making better. The purpose of the research is to investigate the decision support information systems in order to apprise and enhance the capacity of the entities to apply the new knowledge that BI produces for organizational success and competitiveness. The importance of the conducted research consists in identifying solutions to improve reporting and stimulate the entities to start using business intelligence (BI technologies, which facilitate obtaining new information, in order to ensure flexibility, resilience and provide answers to questions that go beyond what the pre-defined reports can do to support decision-making. The estimated result is a technical and operational overview of the large companies in Romania, drawing future directions for an improved competitive behaviour and strategic awareness, and identifying the significant factors for optimizing the decision-making process.
This lecture specifies all the dispositions which have been taken by EDF Nuclear and Fossil Generation Department - according to the fact that availability and safety largely depend on the quality of the procedures and their easy handling - in order to develop, adopt and adapt the operating procedures. The following points are treated: General organization of procedures for plant operation during normal and abnormal conditions; Personnel and extend of responsibility involved into the development of procedures (research center, training center, specialized services, nuclear station, etc.); Validation of the procedures by means of full-scope simulators; Modifications of the procedures taking into account operation experience in material and human fields; Development of simulation softs in order to perform the procedures in abnormal situations; Evolution of operating technics and future skills. (orig.)
Mengiste, Shegaw Anagaw; Nielsen, Jeppe
Diffusion and adoption of IT innovations (such as mobile IT) in health care organizations is a dynamic process of change involving multiple stakeholders with competing interests, varying commitments and values. Reporting from a case study of a mobile-based IT innovation in the field of elderly home...... with important aspects of home care practices creating resistance among the health care personal. Extant literature on mobile IT diffusion and adoption in health care has predominantly taken a factor-orientated perspective and with little emphasis on the environment in which organizations are embedded. Instead......, we propose the social worlds approach as a promising theoretical lens to accommodate the tensions, conflicts, and negotiations involved in the process of diffusing and adopting IT innovations in health care settings....
Stenager, E; Knudsen, L; Jensen, K
a significant correlation between results of an attention and perceptual motor speed test i.e. Symbol Digit Modalities test and the ability to read TV-subtitles, but no correlation was found with another attention and perceptual motor speed test, or verbal or visual memory. No correlation between the use......In a cross-sectional study of 94 patients (42 males, 52 females) with definite multiple sclerosis (MS) in the age range 25-55 years, the correlation of neuropsychological tests with the ability to read TV-subtitles and with the use of sedatives is examined. A logistic regression analysis reveals...... of sedatives and results on neuropsychological tests was found. Anxiety was not correlated with the ability to read TV-subtitles. It is concluded that visual deficits but not the use of sedatives may be a confounding factor in neuropsychological testing in MS....
Multiple apheresis makes it possible to obtain at least two labile blood components from a single donor using a cell separator. It can be either multicomponent apheresis leading to the preparation of at least two different blood component types or red blood cell apheresis providing two identical red blood cell concentrates. These techniques available in addition to whole blood donation, are modifying collection strategies in many Etablissements Français du Sang and will contribute to improve stock logistics in the future. In areas with insufficient stock, these procedures will help achieve blood component self-sufficiency. The author first describes the principle underlying different--current or future--techniques as well as their advantages and drawbacks. He finally addresses the potential impact of these processes on the evolution of blood collection and the advantages to be gained.
Learning Activity Management System (LAMS) has been trialled and used by users from many countries around the globe, but despite the positive attitude towards its potential benefits to pedagogical processes its adoption in practice has been uneven, reflecting how difficult it is to make a new technology based concept an integral part of the…
Rushton, Alan; Grant, Margaret; Feast, Julia; Simmonds, John
Background: While studies of ex-orphanage care show adverse effects on development, the longer-term impact on mid-life psychosocial functioning and physical health has not been established. Methods: Orphanage records provided baseline data on a sample of 100 Hong Kong Chinese girls who were subsequently adopted into the UK. A mid-life follow-up…
To provide an update and overview of infectious disease issues in children of international adoption. International adoption by US families has decreased since 2004. Countries from where children are adopted have changed by 2011, with Ethiopia the second largest contributor of international adoptees after China. Since 2003, international adoptees are older, as fewer young children (<1 year of age) have been available for adoption. Although children are declared healthy in their home countries, medical disorders are often missed or become apparent after adoption. Comprehensive evaluations by providers in the USA after adoption frequently identify unsuspected medical disorders, infections, as well as delayed or incomplete vaccination in these recently adopted children. Early identification of infections allows treatment of potential communicable diseases and updating of immunizations. All international adoptees on arrival in the USA should be evaluated by a health practitioner knowledgeable in adoption medicine to identify medical problems, especially infections.
=80. Table 2: Distribution of respondents according to sex and adoption of maize varieties. Sex. Adoption. Replanted hybrid Local varieties Recommended hybrid. Total n. % n. % n. % n ... other sources of technology. Better-educated farmers ...
Habets, M.J.M.; van der Sijde, Peter; Voordijk, Johannes T.
This research examines how the construction industry adopts alternative transport technologies. This paper presents the general characteristics of the adopter and what his perceptions are towards innovative transport technologies. The study focused on four rates of innovation, related tot
Kim, W J
In contrast to the controversial transracial adoption of African American children by Caucasian families in the U.S., international, transracial adoption of Asian children has not received much scientific or societal attention. There has been a steady increase in this unnoticed minority group, made up largely of Korean children. This paper reviews the developmental characteristics of post-adoption adjustments among Korean adoptees and discusses the dynamics of their positive adjustments. Sociopolitical issues of international adoptions are also addressed.
Pedersen, Per E.; Nysveen, Herbjørn; Thorbjørnsen, Helge
To pay back the investments made in telecommunication infrastructure, new mobile services must be developed, distributed and adopted. A requirement for developing the right services for the right user segments is an understanding of the users' adoption behavior. Applying a re-specified model of ICT-adoption, we study the adoption of text messaging, contact services, mobile payment services and mobile gaming in four individual surveys. Survey results are integrated and used to investigate how ...
Evangelos Katsamakas; Mingdi Xin
The emergence of open source and Linux has burdened IT managers with the challenge of whether, when, and in what applications to adopt open source software in their firms. We characterize the conditions under which enterprises adopt open source software. We show that adoption depends crucially on network effects, the fit of software with the range of applications used by each firm, and the IT capabilities of a firm. Our model predicts that most firms will adopt a heterogeneous IT architecture...
Jordi Suriñach; Corinne Autant-Bernard; Fabio Manca; Nadine Massard; Rosina Moreno
The main aim of the present study is to analyze the drivers of innovation adoption by (i) developing proper measures able to proxy for innovation adoption and internal market regulations, (ii) identifying the channels through which innovation adoption takes place and (iii) assessing the main determinants of this adoption process within the internal market. An original model is derived from the theoretical literature on innovation diffusion. Results show that the impact of the transmission cha...
Van Biljon, J
Full Text Available intentions are indirectly affected. This supports our argument that social and cultural factors should be represented in a technology adoption model. Several studies have applied TAM to research mobile phone technology adoption, notably Kwon..., affect mobile phone adoption and usage. It included a discussion on the structured interviews conducted to form an understanding of the factors that influence mobile adoption and usage, the pilot survey to test the questionnaire that was based...
Ricardo Andrade Coitinho Filho
Full Text Available This paper analyzes the legal treatment given to adoption in the courts of Rio de Janeiro in the context when the adoption requests are done by homosexual couples. The main purpose is to understand, through the analysis of eight legal adoption documents required by homosexuals, in which way the conceptions about family, parenthood and sexualities are produced by the legal practitioners responsible for conducting adoption applications in the period between 2000 untill 2013.
Mott, Sarah L.; Schiller, Crystal Edler; Richards, Jenny Gringer; O’Hara, Michael W.; Stuart, Scott
Similar to biological mothers during the postpartum period, women who adopt children experience increased stress and life changes that may put them at risk for developing depression and anxiety. The purpose of the current study was to compare levels of depression and anxiety symptoms between postpartum and adoptive women and, among adoptive women, to examine associations between specific stressors and depressive symptoms. Data from adoptive mothers (n=147), recruited from Holt International, ...
Kornhaber, Mindy L.
This article draws on research conducted over a 10-year period in an attempt to answer three central questions about the widespread adoption of Gardner's theory of multiple intelligences (MI): Why do educators adopt MI? Once MI is adopted, does anything really change in practice? When educators claim MI is working, what is happening in practice?
Lin, Chihung; Lin, I-Chun; Roan, Jinsheng
Prior research on technology usage had largely overlooked the issue of user resistance or barriers to technology acceptance. Prior research on the Electronic Medical Records had largely focused on technical issues but rarely on managerial issues. Such oversight prevented a better understanding of users' resistance to new technologies and the antecedents of technology rejection. Incorporating the enablers and the inhibitors of technology usage intention, this study explores physicians' reactions towards the electronic medical record. The main focus is on the barriers, perceived threat and perceived inequity. 115 physicians from 6 hospitals participated in the questionnaire survey. Structural Equation Modeling was employed to verify the measurement scale and research hypotheses. According to the results, perceived threat shows a direct and negative effect on perceived usefulness and behavioral intentions, as well as an indirect effect on behavioral intentions via perceived usefulness. Perceived inequity reveals a direct and positive effect on perceived threat, and it also shows a direct and negative effect on perceived usefulness. Besides, perceived inequity reveals an indirect effect on behavioral intentions via perceived usefulness with perceived threat as the inhibitor. The research finding presents a better insight into physicians' rejection and the antecedents of such outcome. For the healthcare industry understanding the factors contributing to physicians' technology acceptance is important as to ensure a smooth implementation of any new technology. The results of this study can also provide change managers reference to a smooth IT introduction into an organization. In addition, our proposed measurement scale can be applied as a diagnostic tool for them to better understand the status quo within their organizations and users' reactions to technology acceptance. By doing so, barriers to physicians' acceptance can be identified earlier and more effectively before leading to technology rejection.
Geller, Alan C; Zwirn, Jodie; Rutsch, Linda; Gorham, Sue A; Viswanath, Vish; Emmons, Karen M
To understand the factors that may influence sun protection policy development if the Centers for Disease Control and Prevention guidelines are to be realized. Qualitative research methodology incorporating a socioecological framework using individual or small-group interviews, surveys, and environmental assessments with school superintendents, elementary school principals, elementary school nurses, and parent-teacher organization presidents and co-chairs as well as coding of school documents. Elementary schools in Massachusetts. Nine school superintendents, 18 elementary school principals, 18 elementary school nurses, and 16 parent-teacher organization presidents or co-chairs. Presence of school sun protection policies, sun protection curriculum, and communication portals for sun protection information to parents. None of the schools in the 9 districts had a sun protection policy, and only 1 had any type of sun protection curriculum. However, nearly all principals were receptive to developing sun protection policies and to making structural changes to increase the amount of accessible shade if funding were available. The schools' communication infrastructure could provide a key portal for disseminating sun protection information to parents. Although there are other resources that could be brought to bear, many challenges must be surmounted to develop effective sun protection policies.
Nielsen, Jeppe Agger; Mengiste, Shegaw Anagaw
The diffusion and adoption of information technology innovations (e.g. mobile information technology) in healthcare organizations involves a dynamic process of change with multiple stakeholders with competing interests, varying commitments, and conflicting values. Nevertheless, the extant literature on mobile information technology diffusion and adoption has predominantly focused on organizations and individuals as the unit of analysis, with little emphasis on the environment in which healthcare organizations are embedded. We propose the social worlds approach as a promising theoretical lens for dealing with this limitation together with reports from a case study of a mobile information technology innovation in elderly home care in Denmark including both the sociopolitical and organizational levels in the analysis. Using the notions of social worlds, trajectories, and boundary objects enables us to show how mobile information technology innovation in Danish home care can facilitate negotiation and collaboration across different social worlds in one setting while becoming a source of tension and conflicts in others. The trajectory of mobile information technology adoption was shaped by influential stakeholders in the Danish home care sector. Boundary objects across multiple social worlds legitimized the adoption, but the use arrangement afforded by the new technology interfered with important aspects of home care practices, creating resistance among the healthcare personnel.
Gelovani, Juri G.
The overall objective of this application is to develop novel technologies for non-invasive imaging of adoptive stem cell-based therapies with positron emission tomography (PET) that would be applicable to human patients. To achieve this objective, stem cells will be genetically labeled with a PET-reporter gene and repetitively imaged to assess their distribution, migration, differentiation, and persistence using a radiolabeled reporter probe. This new imaging technology will be tested in adoptive progenitor cell-based therapy models in animals, including: delivery pro-apoptotic genes to tumors, and T-cell reconstitution for immunostimulatory therapy during allogeneic bone marrow progenitor cell transplantation. Technical and Scientific Merits. Non-invasive whole body imaging would significantly aid in the development and clinical implementation of various adoptive progenitor cell-based therapies by providing the means for non-invasive monitoring of the fate of injected progenitor cells over a long period of observation. The proposed imaging approaches could help to address several questions related to stem cell migration and homing, their long-term viability, and their subsequent differentiation. The ability to image these processes non-invasively in 3D and repetitively over a long period of time is very important and will help the development and clinical application of various strategies to control and direct stem cell migration and differentiation. Approach to accomplish the work. Stem cells will be genetically with a reporter gene which will allow for repetitive non-invasive 'tracking' of the migration and localization of genetically labeled stem cells and their progeny. This is a radically new approach that is being developed for future human applications and should allow for a long term (many years) repetitive imaging of the fate of tissues that develop from the transplanted stem cells. Why the approach is appropriate. The novel approach to stem cell imaging
Gelovani, Juri G.
Objectives. The overall objective of this application is to develop novel technologies for non-invasive imaging of adoptive stem cell-based therapies with positron emission tomography (PET) that would be applicable to human patients. To achieve this objective, stem cells will be genetically labeled with a PET-reporter gene and repetitively imaged to assess their distribution, migration, differentiation, and persistence using a radiolabeled reporter probe. This new imaging technology will be tested in adoptive progenitor cell-based therapy models in animals, including: delivery pro-apoptotic genes to tumors, and T-cell reconstitution for immunostimulatory therapy during allogeneic bone marrow progenitor cell transplantation. Technical and Scientific Merits. Non-invasive whole body imaging would significantly aid in the development and clinical implementation of various adoptive progenitor cell-based therapies by providing the means for non-invasive monitoring of the fate of injected progenitor cells over a long period of observation. The proposed imaging approaches could help to address several questions related to stem cell migration and homing, their long-term viability, and their subsequent differentiation. The ability to image these processes non-invasively in 3D and repetitively over a long period of time is very important and will help the development and clinical application of various strategies to control and direct stem cell migration and differentiation. Approach to accomplish the work. Stem cells will be genetically with a reporter gene which will allow for repetitive non-invasive “tracking” of the migration and localization of genetically labeled stem cells and their progeny. This is a radically new approach that is being developed for future human applications and should allow for a long term (many years) repetitive imaging of the fate of tissues that develop from the transplanted stem cells. Why the approach is appropriate. The novel approach to
Conclusions Imminent adopters of EHRs differed from users and non-users. Financial considerations appear to play a major role in adoption decisions. Knowledge of these differences may assist policymakers and healthcare leaders as they work to increase EHR adoption rates.
...-29413] Adoption of Updated EDGAR Filer Manual AGENCY: Securities and Exchange Commission. ACTION: Final... history of Filer Manual rules, please see the cites therein. In support of the adoption of new rule 30b1-7... disseminated. Along with adoption of the Filer Manual, we are amending Rule 301 of Regulation S-T to provide...
... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Receiver shall file adoption notices. 221... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Adoption Publications Required To Show Change in Carrier's Name or Transfer of Operating Control § 221.162 Receiver shall file adoption notices. A receiver...
... 45 Public Welfare 4 2010-10-01 2010-10-01 false Nonrecurring expenses of adoption. 1356.41 Section..., FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.41 Nonrecurring expenses of adoption. (a) The amount of the payment made for...
... adoption. 401.24 Section 401.24 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Water Resources Program § 401.24 Preparation and adoption. The Water Resources Program will be prepared and considered by the Commission for adoption annually...
... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Adoption of predecessor's..., DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF DISTILLED SPIRITS Formulas § 5.28 Adoption of predecessor's formulas. The adoption by a successor of approved Forms 5110.38 (27-B Supplemental) shall be in...
... 32 National Defense 6 2010-07-01 2010-07-01 false Cooperation and adoption. 989.9 Section 989.9... ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.9 Cooperation and adoption. (a) Lead and cooperating agency... resolves disputes concerning which agency is the lead agency. (b) Adoption of EA or EIS. The Air Force...
van der Veen, M.
Explaining e-business adoptionThis dissertation deals with the explanation of e-business adoption in Dutch small and medium sized enterprises. The adoption of e-business plays an important part in making existing business more efficient and effective. Moreover, it is a tool for business development
Children adopted when they are older come with histories, fully formed personalities, and intense anger over what they have lost. Drawing on stories of families who have adopted older children, as well as research, interviews with professionals, and opinions of adults who were adopted as children, this book explores the joys and challenges of…
Resource implications of adopting a restrictive neonatal blood transfusion policy. ... Objective. To determine whether adopting a restrictive BTF policy results in fewer transfusions. Methods. Data were retrospectively collected on all infants who received BTFs in the GSH nursery over a 6-month period following adoption of a ...
Schiller, Crystal Edler; Richards, Jenny Gringer; O’Hara, Michael W.; Stuart, Scott
Similar to biological mothers during the postpartum period, women who adopt children experience increased stress and life changes that may put them at risk for developing depression and anxiety. The purpose of the current study was to compare levels of depression and anxiety symptoms between postpartum and adoptive women and, among adoptive women, to examine associations between specific stressors and depressive symptoms. Data from adoptive mothers (n=147), recruited from Holt International, were compared to existing data from postpartum women (n=147). Differences in the level of depression and anxiety symptoms as measured by the Inventory of Depression and Anxiety Symptoms among postpartum and adoptive women were examined. Associations between specific stressors and depressive symptoms were examined among adoptive mothers. Postpartum and adoptive women had comparable levels of depressive symptoms, but adoptive women reported greater well-being and less anxiety than postpartum women. Stressors (e.g., sleep deprivation, history of infertility, past psychological disorder, and less marital satisfaction) were all significantly associated with depressive symptoms among adoptive women. The level of depressive symptoms was not significantly different between the two groups. In contrast, adoptive women experienced significantly fewer symptoms of anxiety and experienced greater well-being. Additionally, adoptive mothers experienced more depressive symptoms during the year following adoption when the stressors were present. Thus, women with these characteristics should be routinely screened for depression and anxiety. PMID:21725836
In this study, factors that influence adoption and extent of adoption of natural resource conservation activities were identified using two case studies: Bubaare and Bufundi Innovation Platforms in Uganda. The drivers of adoption of community natural resource management strategies are analysed using an Ordered Logit ...
farmers on adoption of new technologies in pig production has positive influence on output of improved pig produced in Obubra Local Government Area of Cross River State. KEY WORDS: Adoption, New technologies, Pig Production, Agricultural Extension Visit. INTRODUCTION. Adoption of agricultural research findings.
Tanellari, Eftila; Kostandini, Genti; Bonabana-Wabbi, Jackline
This paper examines the effects of gender on the adoption of new technologies of peanut production in Eastern Uganda. The findings suggest that females adopt improved varieties at a lower rate compared to males. In addition, females in female-headed households are less likely to adopt.
The study of the pattern and outcome of adoptions in Enugu, Nigeria in order to determine the challenges in the emerging adoption practice in the state. Aretrospective analysis of adoption practices in Enugu Nigeria based on data from the National women\\'s Commission. The NationalWomen\\'s Commission is the statutory ...
This study determined farmers' adoption levels of the cassava varieties and value adding technologies introduced under the project. Data for the study were collected from 260 randomly selected respondents using interview schedule. Farmers' adoption indices were used to summarize information on adoption levels, while ...
Parsons, Sue Christian; Fuxa, Robin; Kander, Faryl; Hardy, Dana
In this critical content analysis of thirty-seven contemporary realistic fiction books about adoption, the authors examine how adoption and adoptive families are depicted in young adult (YA) literature. The critical literacy theoretical frame brings into focus significant social implications of these depictions as the researchers illuminate and…
Zastrow, Charles H.
This dissertation aims to identify the specific satisfactions derived and difficulties encountered by white parents who adopted a preschool-aged Black child, and to assess the overall outcome of white couples-black children adoptions. Two groups; a group of 82 white parents who adopted a Black child, and a matched comparison group of white parents…
Lancaster, Mary K.
Transracial adoption, especially the adoption of black children by whites, is a deep and divisive social issue. Critics note the untapped potential for black families to adopt black children and the unaddressed conditions that bring black children to higher incidence of foster care placement. They emphasize the inability of white parents to…
Vidal de Haymes, Maria; Simon, Shirley
The gap between the number of children of color in care and the recruitment of minority foster and adoptive homes has triggered growing support for transracial adoption. This study explored a number of transracial placements and adoptions, with the goal of identifying, from the perspective of the families interviewed, potential services that would…
Massatti, Richard R.; Vonk, M. Elizabeth; Gregoire, Thomas K.
The present study provides information on the reliability and validity of the Transracial Adoption Parenting Scale (TAPS), a multidimensional 36-item Likert-type scale that measures cultural competence among transracial adoptive (TRA) parents. The TAPS was theoretically developed and refined through feedback from experts in TRA adoption. A…
Hollingsworth, Leslie Doty
Argues that transracial adoption is not necessary to ensure that children of color are adopted in a timely manner. Presents alternative arguments around six issues. A brief history of the transracial adoption controversy is presented and discussed. Summarizes positions of several social work organizations. Makes recommendations for education,…
Samarina, Anna; Sturm, Jan-Egbert
This paper examines how the analysis of inflation targeting (IT) adoption is affected by allowing for a structural change after adoption, using panel probit models for 60 countries over the period 1985-2008. Our findings suggest that there is a structural change after IT adoption. Including the
The influence of respondents' socio-economic characteristics on adoption was investigated along with other factors influencing adoption of the Small-Scale ... be geared towards extension service delivery with specific emphasis to recommended palm oil processing technologies adoption; credit scheme should be made
The study employed adoption index, logit model and stochastic frontier model to assess the adoption status, its determinants and impact on farmers' productivity respectively. The results show that farmers have responded appreciably to intervention programme that promote the use of improved rice varieties with an adoption ...
analysed using descriptive statistics and estimation of empirical model to determine the factors affecting adoption of RWH ... The models used in evaluating adoption should also consider the time element, Secondly, since the main constraints to adoption is ..... high that tanners tail to control it. R eprod u ced by Sabin et G.
This study was conducted with an objective of determining the correlates of adoption of tissue culture banana technology and its impacts on household incomes in Kenya. The results show that while some households have opted not to adopt tissue culture banana biotechnology, almost all the adopters are growing tissue ...
The study explores the developmental consequences for children who have been adopted. The comparison group is comprised of their non- adopted siblings or children in foster homes or group care. A search in scientific databases resulted in more than 3,300 hits about adoption. Among these, 56...
The adoption of proven soil management practices by rural women in Imo State was assessed. The objectives of the study included to determine the soil management practices adopted by the women and to analyse the relationship between the adoption and the rural women's socio-economic characteristics.
The paper examines emerging trends in child fostering and adoption practices among the Igbo in time perspective. It discusses traditional practices that served as alternatives to child adoption in the pre-colonial period, child adoption practice which is one of the legacies of British colonial administration and the various ...
In recent years, the concept of post-adoption depression--with both parallels and differences from postpartum depression--has emerged as a salient descriptor of the experience of a significant minority of newly adoptive parents. This article offers a clinical perspective on post-adoption depression through the stories of several families seen in…
Huizingh, K.R.E.; Brand, M.J.
Most innovation researchers tend to consider innovation adoption as a binary process, implying that companies have either adopted an innovation or not. In this paper we focus on e-commerce as an innovation that can be adopted stepwise. We distinguish between two levels of e-commerce, basic and
The first study of this thesis (Chapter 2) showed that the majority of the internationally adopted children are well adjusted, although a relatively large minority of adopted children had behavior problems of clinical significance or were referred to mental health services compared with non-adopted
Mott, Sarah L; Schiller, Crystal Edler; Richards, Jenny Gringer; O'Hara, Michael W; Stuart, Scott
Similar to biological mothers during the postpartum period, women who adopt children experience increased stress and life changes that may put them at risk for developing depression and anxiety. The purpose of the current study was to compare levels of depression and anxiety symptoms between postpartum and adoptive women and, among adoptive women, to examine associations between specific stressors and depressive symptoms. Data from adoptive mothers (n = 147), recruited from Holt International, were compared to existing data from postpartum women (n = 147). Differences in the level of depression and anxiety symptoms as measured by the Inventory of Depression and Anxiety Symptoms among postpartum and adoptive women were examined. Associations between specific stressors and depressive symptoms were examined among adoptive mothers. Postpartum and adoptive women had comparable levels of depressive symptoms, but adoptive women reported greater well-being and less anxiety than postpartum women. Stressors (e.g., sleep deprivation, history of infertility, past psychological disorder, and less marital satisfaction) were all significantly associated with depressive symptoms among adoptive women. The level of depressive symptoms was not significantly different between the two groups. In contrast, adoptive women experienced significantly fewer symptoms of anxiety and experienced greater well-being. Additionally, adoptive mothers experienced more depressive symptoms during the year following adoption when the stressors were present. Thus, women with these characteristics should be routinely screened for depression and anxiety.
The farmers commonly adopt fertilizers, minimum tillage and bush fallow practices. The truncated negative binomial Count Data model was used to identify factors influencing adoption of the practices. Factors identified as determinants of their adoption of soil conservation practices include: farm size, land tenure, extension ...
Hussain Ahmed Liton
Full Text Available Cultural assimilation and intercultural awareness has been an important hub of modern language and communication studies, underlining a shift that reflects a greater significance of the inseparability of language and culture, and the need to prepare students for effective intercultural communication to thrive in a global work environment. A thriving global workplace requires effective communication skill across cultures in this era of globalization and mass migration. Under the tutelage of such backdrop, this article addresses the terrain of adopting intercultural awareness in EFL classroom teaching/learning and aims at linking culture with language in pursuit of excellence in borderless effective communication. The study, in other words, investigated the linguistic aspects that could be affected by certain cultural dimensions (e.g., beliefs, traditions, taboo words, habits, and norms, religion, social factors, etc. in intercultural communication. This paper uses a questionnaire device to receive some university teachers’ self-reported feedback. This article maintains qualitative and quantitative research methodology. The analytical research result shows that in teaching English, it is necessary to incorporate and develop aspects of cross-cultural awareness as a part of course curriculum to immerse students in effective intercultural communicative competence (ICC.
Tempera, Italo; Klichinsky, Michael; Lieberman, Paul M.
Epstein-Barr Virus (EBV) can establish latent infections with distinct gene expression patterns referred to as latency types. These different latency types are epigenetically stable and correspond to different promoter utilization. Here we explore the three-dimensional conformations of the EBV genome in different latency types. We employed Chromosome Conformation Capture (3C) assay to investigate chromatin loop formation between the OriP enhancer and the promoters that determine type I (Qp) or type III (Cp) gene expression. We show that OriP is in close physical proximity to Qp in type I latency, and to Cp in type III latency. The cellular chromatin insulator and boundary factor CTCF was implicated in EBV chromatin loop formation. Combining 3C and ChIP assays we found that CTCF is physically associated with OriP-Qp loop formation in type I and OriP-Cp loop formation in type III latency. Mutations in the CTCF binding site located at Qp disrupt loop formation between Qp and OriP, and lead to the activation of Cp transcription. Mutation of the CTCF binding site at Cp, as well as siRNA depletion of CTCF eliminates both OriP-associated loops, indicating that CTCF plays an integral role in loop formation. These data indicate that epigenetically stable EBV latency types adopt distinct chromatin architectures that depend on CTCF and mediate alternative promoter targeting by the OriP enhancer. PMID:21829357
Full Text Available Epstein-Barr Virus (EBV can establish latent infections with distinct gene expression patterns referred to as latency types. These different latency types are epigenetically stable and correspond to different promoter utilization. Here we explore the three-dimensional conformations of the EBV genome in different latency types. We employed Chromosome Conformation Capture (3C assay to investigate chromatin loop formation between the OriP enhancer and the promoters that determine type I (Qp or type III (Cp gene expression. We show that OriP is in close physical proximity to Qp in type I latency, and to Cp in type III latency. The cellular chromatin insulator and boundary factor CTCF was implicated in EBV chromatin loop formation. Combining 3C and ChIP assays we found that CTCF is physically associated with OriP-Qp loop formation in type I and OriP-Cp loop formation in type III latency. Mutations in the CTCF binding site located at Qp disrupt loop formation between Qp and OriP, and lead to the activation of Cp transcription. Mutation of the CTCF binding site at Cp, as well as siRNA depletion of CTCF eliminates both OriP-associated loops, indicating that CTCF plays an integral role in loop formation. These data indicate that epigenetically stable EBV latency types adopt distinct chromatin architectures that depend on CTCF and mediate alternative promoter targeting by the OriP enhancer.