Detailed Measurements of Rayleigh-Taylor Mixing at Large and Small Atwood Numbers
International Nuclear Information System (INIS)
Malcolm, J.; Andrews, Ph.D.
2004-01-01
This project has two major tasks: Task 1. The construction of a new air/helium facility to collect detailed measurements of Rayleigh-Taylor (RT) mixing at high Atwood number, and the distribution of these data to LLNL, LANL, and Alliance members for code validation and design purposes. Task 2. The collection of initial condition data from the new Air/Helium facility, for use with validation of RT simulation codes at LLNL and LANL. Also, studies of multi-layer mixing with the existing water channel facility. Over the last twelve (12) months there has been excellent progress, detailed in this report, with both tasks. As of December 10, 2004, the air/helium facility is now complete and extensive testing and validation of diagnostics has been performed. Currently experiments with air/helium up to Atwood numbers of 0.25 (the maximum is 0.75, but the highest Reynolds numbers are at 0.25) are being performed. The progress matches the project plan, as does the budget, and we expect this to continue for 2005. With interest expressed from LLNL we have continued with initial condition studies using the water channel. This work has also progressed well, with one of the graduate Research Assistants (Mr. Nick Mueschke) visiting LLNL the past two summers to work with Dr. O. Schilling. Several journal papers are in preparation that describe the work. Two MSc.'s have been completed (Mr. Nick Mueschke, and Mr. Wayne Kraft, 12/1/03). Nick and Wayne are both pursuing Ph.D.s' funded by this DOE Alliances project. Presently three (3) Ph.D. graduate Research Assistants are supported on the project, and two (2) undergraduate Research Assistants. During the year two (2) journal papers and two (2) conference papers have been published, ten (10) presentations made at conferences, and three (3) invited presentations
Energy Technology Data Exchange (ETDEWEB)
Mueschke, N J; Andrews, M J; Schilling, O
2005-09-26
The initial multi-mode interfacial velocity and density perturbations present at the onset of a small Atwood number, incompressible, miscible, Rayleigh-Taylor instability-driven mixing layer have been quantified using a combination of experimental techniques. The streamwise interfacial and spanwise interfacial perturbations were measured using high-resolution thermocouples and planar laser-induced fluorescence (PLIF), respectively. The initial multi-mode streamwise velocity perturbations at the two-fluid density interface were measured using particle-image velocimetry (PIV). It was found that the measured initial conditions describe an initially anisotropic state, in which the perturbations in the streamwise and spanwise directions are independent of one another. The evolution of various fluctuating velocity and density statistics, together with velocity and density variance spectra, were measured using PIV and high-resolution thermocouple data. The evolution of the velocity and density statistics is used to investigate the early-time evolution and the onset of strongly-nonlinear, transitional dynamics within the mixing layer. The early-time evolution of the density and vertical velocity variance spectra indicate that velocity fluctuations are the dominant mechanism driving the instability development. The implications of the present experimental measurements on the initialization of Reynolds-averaged turbulent transport and mixing models and of direct and large-eddy simulations of Rayleigh-Taylor instability-induced turbulence are discussed.
International Nuclear Information System (INIS)
Malcolm J. Andrews
2006-01-01
This project had two major tasks: Task 1. The construction of a new air/helium facility to collect detailed measurements of Rayleigh-Taylor (RT) mixing at high Atwood number, and the distribution of these data to LLNL, LANL, and Alliance members for code validation and design purposes. Task 2. The collection of initial condition data from the new Air/Helium facility, for use with validation of RT simulation codes at LLNL and LANL. This report describes work done in the last twelve (12) months of the project, and also contains a summary of the complete work done over the three (3) life of the project. As of April 1, 2006, the air/helium facility (Task 1) is now complete and extensive testing and validation of diagnostics has been performed. Initial condition studies (Task 2) is also complete. Detailed experiments with air/helium with Atwood numbers up to 0.1 have been completed, and Atwood numbers of 0.25. Within the last three (3) months we have been able to successfully run the facility at Atwood numbers of 0.5. The progress matches the project plan, as does the budget. We have finished the initial condition studies using the water channel, and this work has been accepted for publication on the Journal of Fluid Mechanics (the top fluid mechanics journal). Mr. Nick Mueschke and Mr. Wayne Kraft are continuing with their studies to obtain PhDs in the same field, and will also continue their collaboration visits to LANL and LLNL. Over its three (3) year life the project has supported two(2) Ph.D.'s and three (3) MS's, and produced nine (9) international journal publications, twenty four (24) conference publications, and numerous other reports. The highlight of the project has been our close collaboration with LLNL (Dr. Oleg Schilling) and LANL (Drs. Dimonte, Ristorcelli, Gore, and Harlow)
Effects of Atwood number on shock focusing in shock-cylinder interaction
Ou, Junfeng; Ding, Juchun; Luo, Xisheng; Zhai, Zhigang
2018-02-01
The evolution of shock-accelerated heavy-gas cylinder surrounded by the air with different Atwood numbers (A_t=0.28, 0.50, 0.63) is investigated, concentrating on shock focusing and jet formation. Experimentally, a soap film technique is used to generate an ideal two-dimensional discontinuous gas cylinder with a clear surface, which can guarantee the observation of shock wave movements inside the cylinder. Different Atwood numbers are realized by different mixing ratios of SF_6 and air inside the cylinder. A high-speed schlieren system is adopted to capture the shock motions and jet morphology. Numerical simulations are also performed to provide more information. The results indicate that an inward jet is formed for low Atwood numbers, while an outward jet is generated for high Atwood numbers. Different Atwood numbers will lead to the differences in the relative velocities between the incident shock and the refraction shock, which ultimately results in the differences in shock competition near the downstream pole. The morphology and feature of the jet are closely associated with the position and intensity of shock focusing. The pressure and vorticity contours indicate that the jet formation should be attributed to the pressure pulsation caused by shock focusing, and the jet development is ascribed to the vorticity induction. Finally, a time ratio proposed in the previous work for determining the shock-focusing type is verified by experiments.
Miller, S.; Knauer, J. P.; Radha, P. B.; Goncharov, V. N.
2017-10-01
Performance degradation in direct-drive inertial confinement fusion implosions can be caused by several effects, one of which is Rayleigh-Taylor (RT) instability growth during the deceleration phase. In room-temperature plastic target implosions, this deceleration-phase RT growth is enhanced by the density discontinuity and finite Atwood numbers at the fuel-pusher interface. For the first time, an experimental campaign at the Omega Laser Facility systematically varied the ratio of deuterium-to-tritium (D-to-T) within the DT gas fill to change the Atwood number. The goal of the experiment was to understand the effects of Atwood number variation on observables like apparent ion temperature, yield, and variations in areal density and bulk fluid motion, which lead to broadening of neutron spectra along different lines of sight. Simulations by the hydrodynamic codes LILAC and DRACO were used to study growth rates for different D-to-T ratios and identify observable quantities effected by Atwood number variation. Results from simulations and the experiment are presented. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.
Stabilization of ablative Rayleigh-Taylor instability due to change of the Atwood number
International Nuclear Information System (INIS)
Ye Wenhua; He, X.T.; Zhang Weiyan
2002-01-01
Recent experiment [S.G. Glendinning et al., Phys. Rev. Lett. 78, 3318 (1997)] showed that the measured growth rate of laser ablative Rayleigh-Taylor (RT) instability with preheating is about 50% of the classic value and is reduced by about 18% compared with the simulated value obtained with the computer code LASNEX. By changing the temperature variation of the electron thermal conductivity at low temperatures, the density profile from the Bhatnagar-Gross-Krook approximation is recovered in the simulation, and the simulated RT growth rate is in good agreement with the experimental value from Glendinning et al. The preheated density profile on ablative RT stablization is studied numerically. A change of the Atwood number in the preheating case also leads to RT stabilization. The RT growth formula γ=√(Akg/(1+AkL))-2kV a agrees well with experiment and simulation, and is appropriate for the preheating case
Self-similarity in high Atwood number Rayleigh-Taylor experiments
Mikhaeil, Mark; Suchandra, Prasoon; Pathikonda, Gokul; Ranjan, Devesh
2017-11-01
Self-similarity is a critical concept in turbulent and mixing flows. In the Rayleigh-Taylor instability, theory and simulations have shown that the flow exhibits properties of self-similarity as the mixing Reynolds number exceeds 20000 and the flow enters the turbulent regime. Here, we present results from the first large Atwood number (0.7) Rayleigh-Taylor experimental campaign for mixing Reynolds number beyond 20000 in an effort to characterize the self-similar nature of the instability. Experiments are performed in a statistically steady gas tunnel facility, allowing for the evaluation of turbulence statistics. A visualization diagnostic is used to study the evolution of the mixing width as the instability grows. This allows for computation of the instability growth rate. For the first time in such a facility, stereoscopic particle image velocimetry is used to resolve three-component velocity information in a plane. Velocity means, fluctuations, and correlations are considered as well as their appropriate scaling. Probability density functions of velocity fields, energy spectra, and higher-order statistics are also presented. The energy budget of the flow is described, including the ratio of the kinetic energy to the released potential energy. This work was supported by the DOE-NNSA SSAA Grant DE-NA0002922.
International Nuclear Information System (INIS)
Liu, Wanhai; Yu, Changping; Li, Xinliang
2014-01-01
Nonlinear saturation amplitudes (NSAs) of the first two harmonics in classical Rayleigh-Taylor instability (RTI) in cylindrical geometry for arbitrary Atwood numbers have been analytically investigated considering nonlinear corrections up to the fourth-order. The NSA of the fundamental mode is defined as the linear (purely exponential) growth amplitude of the fundamental mode at the saturation time when the growth of the fundamental mode (first harmonic) is reduced by 10% in comparison to its corresponding linear growth, and the NSA of the second harmonic can be obtained in the same way. The analytic results indicate that the effects of the initial radius of the interface (r 0 ) and the Atwood number (A) play an important role in the NSAs of the first two harmonics in cylindrical RTI. On the one hand, the NSA of the fundamental mode first increases slightly and then decreases quickly with increasing A. For given A, the smaller the r 0 /λ (with λ perturbation wavelength) is, the larger the NSA of the fundamental mode is. When r 0 /λ is large enough (r 0 ≫λ), the NSA of the fundamental mode is reduced to the prediction of previous literatures within the framework of third-order perturbation theory [J. W. Jacobs and I. Catton, J. Fluid Mech. 187, 329 (1988); S. W. Haan, Phys. Fluids B 3, 2349 (1991)]. On the other hand, the NSA of the second harmonic first decreases quickly with increasing A, reaching a minimum, and then increases slowly. Furthermore, the r 0 can reduce the NSA of the second harmonic for arbitrary A at r 0 ≲2λ while increase it for A ≲ 0.6 at r 0 ≳2λ. Thus, it should be included in applications where the NSA has a role, such as inertial confinement fusion ignition target design
Atwood and Poggendorff: an insightful analogy
DEFF Research Database (Denmark)
Coelho, Ricardo; Borges, Paulo; Avelar Sotomaior Karam, Ricardo
2016-01-01
- librium provide us with the solution for a compound Atwood machine with the same bodies. This analogy is pedagogically useful because it illustrates a common strategy to transform a dynamic in a static situation improving stu- dents’ comprehension of Newton’s laws and equilibrium.......Atwood’s treatise, in which the Atwood machine appears, was published in 1784. About 70 years later, Poggendorff showed experimentally that the weight of an Atwood machine is reduced when it is brought to motion. In the present paper, a twofold connection between this experiment and the Atwood...... machine is established. Firstly, if the Poggendorff apparatus is taken as an ideal one, the equations of motion of the apparatus coincide with the equations of motion of the compound Atwood machine. Secondly, if the Poggendorff apparatus, which works as a lever, is rebalanced, the equations of this equi...
Atwood and Poggendorff: an insightful analogy
Coelho, R. L.; Borges, P. F.; Karam, R.
2016-11-01
Atwood’s treatise, in which the Atwood machine appears, was published in 1784. About 70 years later, Poggendorff showed experimentally that the weight of an Atwood machine is reduced when it is brought to motion. In the present paper, a twofold connection between this experiment and the Atwood machine is established. Firstly, if the Poggendorff apparatus is taken as an ideal one, the equations of motion of the apparatus coincide with the equations of motion of the compound Atwood machine. Secondly, if the Poggendorff apparatus, which works as a lever, is rebalanced, the equations of this equilibrium provide us with the solution for a compound Atwood machine with the same bodies. This analogy is pedagogically useful because it illustrates a common strategy to transform a dynamic in a static situation improving students’ comprehension of Newton’s laws and equilibrium.
Decomposition of the compound Atwood machine
Lopes Coelho, R.
2017-11-01
Non-standard solving strategies for the compound Atwood machine problem have been proposed. The present strategy is based on a very simple idea. Taking an Atwood machine and replacing one of its bodies by another Atwood machine, we have a compound machine. As this operation can be repeated, we can construct any compound Atwood machine. This rule of construction is transferred to a mathematical model, whereby the equations of motion are obtained. The only difference between the machine and its model is that instead of pulleys and bodies, we have reference frames that move solidarily with these objects. This model provides us with the accelerations in the non-inertial frames of the bodies, which we will use to obtain the equations of motion. This approach to the problem will be justified by the Lagrange method and exemplified by machines with six and eight bodies.
''Diagonalization'' of a compound Atwood machine
International Nuclear Information System (INIS)
Crawford, F.S.
1987-01-01
We consider a simple Atwood machine consisting of a massless frictionless pulley no. 0 supporting two masses m 1 and m 2 connected by a massless flexible string. We show that the string that supports massless pulley no. 0 ''thinks'' it is simply supporting a mass m 0 , with m 0 = 4m 1 m 2 /(m 1 +m 2 ). This result, together with Einstein's equivalence principle, allows us to solve easily those compound Atwood machines created by replacing one or both of m 1 and m 2 in machine no. 0 by an Atwood machine. We may then replacing the masses in these new machines by machines, etc. The complete solution can be written down immediately, without solving simultaneous equations. Finally we give the effective mass of an Atwood machine whose pulley has nonzero mass and moment of inertia
On Atwood's Machine with a Nonzero Mass String
Tarnopolski, Mariusz
2015-01-01
Let us consider a classical high school exercise concerning two weights on a pulley and a string, illustrated in Fig. 1(a). A system like this is called an Atwood's machine and was invented by George Atwood in 1784 as a laboratory experiment to verify the mechanical laws of motion with constant acceleration. Nowadays, Atwood's machine is used for…
Study of a variable mass Atwood's machine using a smartphone
Lopez, Dany; Caprile, Isidora; Corvacho, Fernando; Reyes, Orfa
2018-03-01
The Atwood machine was invented in 1784 by George Atwood and this system has been widely studied both theoretically and experimentally over the years. Nowadays, it is commonplace that many experimental physics courses include both Atwood's machine and variable mass to introduce more complex concepts in physics. To study the dynamics of the masses that compose the variable Atwood's machine, laboratories typically use a smart pulley. Now, the first work that introduced a smartphone as data acquisition equipment to study the acceleration in the Atwood's machine was the one by M. Monteiro et al. Since then, there has been no further information available on the usage of smartphones in variable mass systems. This prompted us to do a study of this kind of system by means of data obtained with a smartphone and to show the practicality of using smartphones in complex experimental situations.
Mohaghar, Mohammad; Carter, John; Pathikonda, Gokul; Ranjan, Devesh
2017-11-01
The current study experimentally investigates the influence of the initial Atwood ratio (At) on the evolution of Richtmyer-Meshkov instability at the Georgia Tech Shock Tube and Advanced Mixing Laboratory. Two Atwood numbers (At =0.22 and 0.67) are studied, which correspond to the gas combinations of nitrogen seeded with acetone vapor (light) over carbon dioxide (heavy) and same light gas over sulfur hexafluoride (heavy) respectively. A perturbed, multi-mode, inclined interface (with an amplitude to wavelength ratio of 0.088) is impulsively accelerated by the incident shock traveling vertically from light to heavy gas with a Mach number 1.55. The effect of Atwood ratio on turbulent mixing transition after reshock at the same non-dimensional times between the two cases is examined through ensemble-averaged turbulence statistics from simultaneous planar laser induced uorescence (PLIF) and particle image velocimetry (PIV) measurements. Preliminary studies over the smaller Atwood number indicates that turbulent mixing transition criteria can be satisfied after reshock. This work was supported by the National Science Foundation CAREER Award No. 1451994.
Small Numbers From Tunneling Between Brane Throats
Energy Technology Data Exchange (ETDEWEB)
Kachru, Shamit
2001-07-25
Generic classes of string compactifications include ''brane throats'' emanating from the compact dimensions and separated by effective potential barriers raised by the background gravitational fields. The interaction of observers inside different throats occurs via tunneling and is consequently weak. This provides a new mechanism for generating small numbers in Nature. We apply it to the hierarchy problem, where supersymmetry breaking near the unification scale causes TeV sparticle masses inside the standard model throat. We also design naturally long-lived cold dark matter which decays within a Hubble time to the approximate conformal matter of a long throat. This may soften structure formation at galactic scales and raises the possibility that much of the dark matter of the universe is conformal matter. Finally, the tunneling rate shows that the coupling between throats, mediated by bulk modes, is stronger than a naive application of holography suggests.
Small numbers from tunneling between brane throats
International Nuclear Information System (INIS)
Kaloper, Nemanja
2003-01-01
In generic string compactifications with branes, the regions of space in the vicinity of brane horizons, or brane throats, support effective potential barriers, raised by the back-ground gravitational fields. A familiar example is the AdS brane throats in the Randall-Sundrum model. The barriers obstruct the interaction of observers inside different throats, whose communication is effectively described by tunneling through the barriers. Consequently the interactions between different throats are exponentially weak. This provides for a new mechanism for explaining small numbers in Nature. We review the applications to the hierarchy problem where supersymmetry breaking scale is reduced by tunneling, long-lived cold dark matter particles which decay into hot CFT, and consider the implications for holography. We finally discuss the important interplay between the tunneling suppression and our recent conjecture that black holes stuck on a brane in AdS D+1 should be interpreted as duals of quantum-corrected D-dimensional black holes, rather than classical ones, of a CFT coupled to gravity. (author)
Small numbers in supersymmetric theories of nature
International Nuclear Information System (INIS)
Graesser, Michael L.
1999-01-01
of this dissertation is both the phenomenology and model-building opportunities that may lie behind the small numbers that appear in supersymmetric extensions of the Standard Model
Study of a Variable Mass Atwood's Machine Using a Smartphone
Lopez, Dany; Caprile, Isidora; Corvacho, Fernando; Reyes, Orfa
2018-01-01
The Atwood machine was invented in 1784 by George Atwood and this system has been widely studied both theoretically and experimentally over the years. Nowadays, it is commonplace that many experimental physics courses include both Atwood's machine and variable mass to introduce more complex concepts in physics. To study the dynamics of the masses…
Hierarchies in Quantum Gravity: Large Numbers, Small Numbers, and Axions
Stout, John Eldon
Our knowledge of the physical world is mediated by relatively simple, effective descriptions of complex processes. By their very nature, these effective theories obscure any phenomena outside their finite range of validity, discarding information crucial to understanding the full, quantum gravitational theory. However, we may gain enormous insight into the full theory by understanding how effective theories with extreme characteristics--for example, those which realize large-field inflation or have disparate hierarchies of scales--can be naturally realized in consistent theories of quantum gravity. The work in this dissertation focuses on understanding the quantum gravitational constraints on these "extreme" theories in well-controlled corners of string theory. Axion monodromy provides one mechanism for realizing large-field inflation in quantum gravity. These models spontaneously break an axion's discrete shift symmetry and, assuming that the corrections induced by this breaking remain small throughout the excursion, create a long, quasi-flat direction in field space. This weakly-broken shift symmetry has been used to construct a dynamical solution to the Higgs hierarchy problem, dubbed the "relaxion." We study this relaxion mechanism and show that--without major modifications--it can not be naturally embedded within string theory. In particular, we find corrections to the relaxion potential--due to the ten-dimensional backreaction of monodromy charge--that conflict with naive notions of technical naturalness and render the mechanism ineffective. The super-Planckian field displacements necessary for large-field inflation may also be realized via the collective motion of many aligned axions. However, it is not clear that string theory provides the structures necessary for this to occur. We search for these structures by explicitly constructing the leading order potential for C4 axions and computing the maximum possible field displacement in all compactifications of
Boundary induced nonlinearities at small Reynolds numbers
Sbragaglia, M.; Sugiyama, K.
2007-01-01
We investigate the importance of boundary slip at finite Reynolds numbers for mixed boundary conditions. Nonlinear effects are induced by the non-homogeneity of the boundary condition and change the symmetry properties of the flow with an overall mean flow reduction. To explain the observed drag
Normal solutions of the Boltzmann equation with small Knudsen number
International Nuclear Information System (INIS)
Ding, E.J.; Huang, Z.Q.
1986-01-01
A singular perturbation method is used to find the normal solutions of the Boltzmann equation with small Knudsen number. It is proved that the secular terms may be removed by improving the Hilbert expansion and the Enskog expansion
MARGARET ATWOOD'S NON-FICTION ABOUT FICTION: PAYBACK
Directory of Open Access Journals (Sweden)
Igor Maver
2015-10-01
Full Text Available Margaret Atwood's provocative recent book of non-fiction contains many literary references, which help to effectively highlight her points about such a topical matter as debt, debt as a philosophical, politico-economic, religious, and historical issue over the centuries. In the central chapters of the book she looks at the Protestant Reformation and the introduction of interest on loans and in this light analyzes the novels by Dickens, Irving, Thackeray and G. Eliot. Her final statement in the book is, however, about the ecological debt we all have to pay to Earth in order to ensure our existence.
Small-scale dynamo at low magnetic Prandtl numbers
Schober, Jennifer; Schleicher, Dominik; Bovino, Stefano; Klessen, Ralf S.
2012-12-01
The present-day Universe is highly magnetized, even though the first magnetic seed fields were most probably extremely weak. To explain the growth of the magnetic field strength over many orders of magnitude, fast amplification processes need to operate. The most efficient mechanism known today is the small-scale dynamo, which converts turbulent kinetic energy into magnetic energy leading to an exponential growth of the magnetic field. The efficiency of the dynamo depends on the type of turbulence indicated by the slope of the turbulence spectrum v(ℓ)∝ℓϑ, where v(ℓ) is the eddy velocity at a scale ℓ. We explore turbulent spectra ranging from incompressible Kolmogorov turbulence with ϑ=1/3 to highly compressible Burgers turbulence with ϑ=1/2. In this work, we analyze the properties of the small-scale dynamo for low magnetic Prandtl numbers Pm, which denotes the ratio of the magnetic Reynolds number, Rm, to the hydrodynamical one, Re. We solve the Kazantsev equation, which describes the evolution of the small-scale magnetic field, using the WKB approximation. In the limit of low magnetic Prandtl numbers, the growth rate is proportional to Rm(1-ϑ)/(1+ϑ). We furthermore discuss the critical magnetic Reynolds number Rmcrit, which is required for small-scale dynamo action. The value of Rmcrit is roughly 100 for Kolmogorov turbulence and 2700 for Burgers. Furthermore, we discuss that Rmcrit provides a stronger constraint in the limit of low Pm than it does for large Pm. We conclude that the small-scale dynamo can operate in the regime of low magnetic Prandtl numbers if the magnetic Reynolds number is large enough. Thus, the magnetic field amplification on small scales can take place in a broad range of physical environments and amplify week magnetic seed fields on short time scales.
Small-scale dynamo at low magnetic Prandtl numbers.
Schober, Jennifer; Schleicher, Dominik; Bovino, Stefano; Klessen, Ralf S
2012-12-01
The present-day Universe is highly magnetized, even though the first magnetic seed fields were most probably extremely weak. To explain the growth of the magnetic field strength over many orders of magnitude, fast amplification processes need to operate. The most efficient mechanism known today is the small-scale dynamo, which converts turbulent kinetic energy into magnetic energy leading to an exponential growth of the magnetic field. The efficiency of the dynamo depends on the type of turbulence indicated by the slope of the turbulence spectrum v(ℓ)∝ℓ^{ϑ}, where v(ℓ) is the eddy velocity at a scale ℓ. We explore turbulent spectra ranging from incompressible Kolmogorov turbulence with ϑ=1/3 to highly compressible Burgers turbulence with ϑ=1/2. In this work, we analyze the properties of the small-scale dynamo for low magnetic Prandtl numbers Pm, which denotes the ratio of the magnetic Reynolds number, Rm, to the hydrodynamical one, Re. We solve the Kazantsev equation, which describes the evolution of the small-scale magnetic field, using the WKB approximation. In the limit of low magnetic Prandtl numbers, the growth rate is proportional to Rm^{(1-ϑ)/(1+ϑ)}. We furthermore discuss the critical magnetic Reynolds number Rm_{crit}, which is required for small-scale dynamo action. The value of Rm_{crit} is roughly 100 for Kolmogorov turbulence and 2700 for Burgers. Furthermore, we discuss that Rm_{crit} provides a stronger constraint in the limit of low Pm than it does for large Pm. We conclude that the small-scale dynamo can operate in the regime of low magnetic Prandtl numbers if the magnetic Reynolds number is large enough. Thus, the magnetic field amplification on small scales can take place in a broad range of physical environments and amplify week magnetic seed fields on short time scales.
Confidence limits for small numbers of events in astrophysical data
Gehrels, N.
1986-01-01
The calculation of limits for small numbers of astronomical counts is based on standard equations derived from Poisson and binomial statistics; although the equations are straightforward, their direct use is cumbersome and involves both table-interpolations and several mathematical operations. Convenient tables and approximate formulae are here presented for confidence limits which are based on such Poisson and binomial statistics. The limits in the tables are given for all confidence levels commonly used in astrophysics.
Margaret Atwood: la sirena de géneros
Directory of Open Access Journals (Sweden)
Freire, Espido
2009-06-01
Full Text Available En la narrativa de Margaret Atwood la sorpresa, el uso poético del lenguaje y la reconstrucción constante de la identidad de los personajes guían al lector a traves de los distintos textos. Tanto en la reconstrucción de Los diarios de Susanna Moodie como en la traducción de emociones y sentimientos de la reina de Dinamarca en «La respuesta de Getrudis», la figura de las protagonistas femeninas fuertes e imprevisibles reinventan el misterio del eterno femenino. Las criadas y las señoras, desde sus peculiares puntos de vista, definen la sociedad con distancia y escepticismo, sabedoras de que son más de lo que el otro (el lector o los personajes pueden atisbar. En un acto lúdico constante, la literatura se convierte en un juego eterno, con las palabras como reglas.
Small numbers are sensed directly, high numbers constructed from size and density.
Zimmermann, Eckart
2018-04-01
Two theories compete to explain how we estimate the numerosity of visual object sets. The first suggests that the apparent numerosity is derived from an analysis of more low-level features like size and density of the set. The second theory suggests that numbers are sensed directly. Consistent with the latter claim is the existence of neurons in parietal cortex which are specialized for processing the numerosity of elements in the visual scene. However, recent evidence suggests that only low numbers can be sensed directly whereas the perception of high numbers is supported by the analysis of low-level features. Processing of low and high numbers, being located at different levels of the neural hierarchy should involve different receptive field sizes. Here, I tested this idea with visual adaptation. I measured the spatial spread of number adaptation for low and high numerosities. A focused adaptation spread of high numerosities suggested the involvement of early neural levels where receptive fields are comparably small and the broad spread for low numerosities was consistent with processing of number neurons which have larger receptive fields. These results provide evidence for the claim that different mechanism exist generating the perception of visual numerosity. Whereas low numbers are sensed directly as a primary visual attribute, the estimation of high numbers however likely depends on the area size over which the objects are spread. Copyright © 2017 Elsevier B.V. All rights reserved.
Ensembles of a small number of conformations with relative populations
Energy Technology Data Exchange (ETDEWEB)
Vammi, Vijay, E-mail: vsvammi@iastate.edu; Song, Guang, E-mail: gsong@iastate.edu [Iowa State University, Bioinformatics and Computational Biology Program, Department of Computer Science (United States)
2015-12-15
In our previous work, we proposed a new way to represent protein native states, using ensembles of a small number of conformations with relative Populations, or ESP in short. Using Ubiquitin as an example, we showed that using a small number of conformations could greatly reduce the potential of overfitting and assigning relative populations to protein ensembles could significantly improve their quality. To demonstrate that ESP indeed is an excellent alternative to represent protein native states, in this work we compare the quality of two ESP ensembles of Ubiquitin with several well-known regular ensembles or average structure representations. Extensive amount of significant experimental data are employed to achieve a thorough assessment. Our results demonstrate that ESP ensembles, though much smaller in size comparing to regular ensembles, perform equally or even better sometimes in all four different types of experimental data used in the assessment, namely, the residual dipolar couplings, residual chemical shift anisotropy, hydrogen exchange rates, and solution scattering profiles. This work further underlines the significance of having relative populations in describing the native states.
Human Activity Recognition by Combining a Small Number of Classifiers.
Nazabal, Alfredo; Garcia-Moreno, Pablo; Artes-Rodriguez, Antonio; Ghahramani, Zoubin
2016-09-01
We consider the problem of daily human activity recognition (HAR) using multiple wireless inertial sensors, and specifically, HAR systems with a very low number of sensors, each one providing an estimation of the performed activities. We propose new Bayesian models to combine the output of the sensors. The models are based on a soft outputs combination of individual classifiers to deal with the small number of sensors. We also incorporate the dynamic nature of human activities as a first-order homogeneous Markov chain. We develop both inductive and transductive inference methods for each model to be employed in supervised and semisupervised situations, respectively. Using different real HAR databases, we compare our classifiers combination models against a single classifier that employs all the signals from the sensors. Our models exhibit consistently a reduction of the error rate and an increase of robustness against sensor failures. Our models also outperform other classifiers combination models that do not consider soft outputs and an Markovian structure of the human activities.
Spectra of turbulently advected scalars that have small Schmidt number
Hill, Reginald J.
2017-09-01
Exact statistical equations are derived for turbulent advection of a passive scalar having diffusivity much larger than the kinematic viscosity, i.e., small Schmidt number. The equations contain all terms needed for precise direct numerical simulation (DNS) quantification. In the appropriate limit, the equations reduce to the classical theory for which the scalar spectrum is proportional to the energy spectrum multiplied by k-4, which, in turn, results in the inertial-diffusive range power law, k-17 /3. The classical theory was derived for the case of isotropic velocity and scalar fields. The exact equations are simplified for less restrictive cases: (1) locally isotropic scalar fluctuations at dissipation scales with no restriction on symmetry of the velocity field, (2) isotropic velocity field with averaging over all wave-vector directions with no restriction on the symmetry of the scalar, motivated by that average being used for DNS, and (3) isotropic velocity field with axisymmetric scalar fluctuations, motivated by the mean-scalar-gradient-source case. The equations are applied to recently published DNSs of passive scalars for the cases of a freely decaying scalar and a mean-scalar-gradient source. New terms in the exact equations are estimated for those cases and are found to be significant; those terms cause the deviations from the classical theory found by the DNS studies. A new formula for the mean-scalar-gradient case explains the variation of the scalar spectra for the DNS of the smallest Schmidt-number cases. Expansion in Legendre polynomials reveals the effect of axisymmetry. Inertial-diffusive-range formulas for both the zero- and second-order Legendre contributions are given. Exact statistical equations reveal what must be quantified using DNS to determine what causes deviations from asymptotic relationships.
Generating Small Numbers by Tunneling in Multi-Throat Compactifications
Energy Technology Data Exchange (ETDEWEB)
Silverstein, Eva M
2001-07-25
A generic F-theory compactification containing many D3 branes develops multiple brane throats. The interaction of observers residing inside different throats involves tunneling suppression and, as a result, is very weak. This suggests a new mechanism for generating small numbers in Nature. One application is to the hierarchy problem: large supersymmetry breaking near the unification scale inside a shallow throat causes TeV-scale SUSY-breaking inside the standard-model throat. Another application, inspired by nuclear-decay, is in designing naturally long-lived particles: a cold dark matter particle residing near the standard model brane decays to an approximate CFT-state of a longer throat within a Hubble time. This suggests that most of the mass of the universe today could consist of CFT-matter and may soften structure formation at sub-galactic scales. The tunneling calculation demonstrates that the coupling between two throats is dominated by higher dimensional modes and consequently is much larger than a naive application of holography might suggest.
Women's Oppressed and Disfigured Life in Margaret Atwood's the Handmaid's Tale
Zarrinjooee, Bahman; Kalantarian, Shirin
2017-01-01
The present study attempts to analyze Margaret Atwood's (1939-) "The Handmaid's Tale" (1985) based on theories of feminist thinker, Simone de Beauvoir (1908-1986) and applies her theories presented in "The Second Sex" (1949) that leads to better apprehension of sex and gender. Beauvoir's ideology focuses mainly on the cultural…
The Ramsey numbers of large cycles versus small wheels
Surahmat,; Baskoro, E.T.; Broersma, H.J.
2004-01-01
For two given graphs G and H, the Ramsey number R(G;H) is the smallest positive integer N such that for every graph F of order N the following holds: either F contains G as a subgraph or the complement of F contains H as a subgraph. In this paper, we determine the Ramsey number R(Cn;Wm) for m = 4
Connected size Ramsey number for matchings vs. small stars or ...
Indian Academy of Sciences (India)
2017-11-20
Nov 20, 2017 ... determine the connected size Ramsey number ˆrc(nK2, K1,3)forn ≥ 2 ... concerning the size Ramsey number for many pairs of graphs can be seen in [3]. ... Then, color all edges incident to x by red and the other edges of F by.
Energy transfers in dynamos with small magnetic Prandtl numbers
Kumar, Rohit; Verma, Mahendra K.; Samtaney, Ravi
2015-01-01
We perform numerical simulation of dynamo with magnetic Prandtl number Pm = 0.2 on 10243 grid, and compute the energy fluxes and the shell-to-shell energy transfers. These computations indicate that the magnetic energy growth takes place mainly due
Energy transfers in dynamos with small magnetic Prandtl numbers
Kumar, Rohit
2015-06-25
We perform numerical simulation of dynamo with magnetic Prandtl number Pm = 0.2 on 10243 grid, and compute the energy fluxes and the shell-to-shell energy transfers. These computations indicate that the magnetic energy growth takes place mainly due to the energy transfers from large-scale velocity field to large-scale magnetic field and that the magnetic energy flux is forward. The steady-state magnetic energy is much smaller than the kinetic energy, rather than equipartition; this is because the magnetic Reynolds number is near the dynamo transition regime. We also contrast our results with those for dynamo with Pm = 20 and decaying dynamo. © 2015 Taylor & Francis.
Android Used in The Learning Innovation Atwood Machines on Lagrange Mechanics Methods
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Shabrina Shabrina
2017-12-01
Full Text Available Android is one of the smartphone operating system platforms that is now widely developed in learning media. Android allows the learning process to be more flexible and not oriented to be teacher center, but it allows to be student center. The Atwood machines is an experimental tool that is often used to observe mechanical laws in constantly accelerated motion which can also be described by the Lagrange mechanics methods. As an innovative and alternative learning activity, Atwood Android-based learning apps are running for two experimental variations, which are variations in load in cart and load masses that are hung. The experiment of load-carrier mass variation found that the larger load mass in the cart, the smaller the acceleration experienced by the system. Meanwhile, the experiment on the variation of the loaded mass found that the larger the loaded mass, the greater the acceleration experienced by the system.
Directory of Open Access Journals (Sweden)
Thiago M. Moyano
2018-04-01
Full Text Available ABSTRACT: In the poststructuralist turn, a less unified and universalizing concept of space as merely a meaningless stage is proposed. Such notion, as Michel Foucault announced in the 1970s, will no longer be perceived by its fixity or a simply referential aspect, acquiring, among different forums of discussion in the Humanities, a dynamic character. In parallel fashion, studies concerning the constitution of subjectivity point towards its oscillating status, showing how the subject is the product of multiple discourses, which makes any demarcating of solid frontiers, a hard task. The present work aims at analyzing the novel Alias Grace (1996 by Margaret Atwood, under the light of spatial criticism, as well as Gender theory, deconstructing essentialisms around women. In this novel, Atwood gives voice to the historical figure Grace Marks, young Irish immigrant in the XIX century, which becomes mentor and accomplice of the murder of her employer, Thomas Kinnear, and his mistress and governess of the house, Nancy Montgomery. The author constructs a self-aware character-narrator who will know how to manipulate, through language, the many contexts in which she finds herself in, reversing the hierarchy of discourse, re-signifying her allegedly inferior position. Works by Philip Wegner and Neil Smith around the notion of space, Lorna McLean and Marilyn Barber about the Irish immigration in Canada, as well as Linda Hutcheon, Chris Weedon, and Jane Flax’s theories will be the theoretical apparatus of this investigation. KEYWORDS: Gender, Space, Post-colonialism, Margaret Atwood. __________________________________ RESUMO: A guinada Pós-estruturalista de meados do século XX propôs uma visão menos unificada e universalizante do conceito de espaço, este visto anteriormente como um mero cenário. Tal noção, conforme prenunciava Foucault nos anos 1970, não mais será compreendida por sua fixidez ou valor referencial, adquirindo, nos mais variados f
Taking It to the Classroom: Number Board Games as a Small Group Learning Activity
Ramani, Geetha B.; Siegler, Robert S.; Hitti, Aline
2012-01-01
We examined whether a theoretically based number board game could be translated into a practical classroom activity that improves Head Start children's numerical knowledge. Playing the number board game as a small group learning activity promoted low-income children's number line estimation, magnitude comparison, numeral identification, and…
Pseudorandom Recursions: Small and Fast Pseudorandom Number Generators for Embedded Applications
Directory of Open Access Journals (Sweden)
Petruska Gyorgy
2007-01-01
Full Text Available Many new small and fast pseudorandom number generators are presented, which pass the most common randomness tests. They perform only a few, nonmultiplicative operations for each generated number, use very little memory, therefore, they are ideal for embedded applications. We present general methods to ensure very long cycles and show, how to create super fast, very small ciphers and hash functions from them.
Pseudorandom Recursions: Small and Fast Pseudorandom Number Generators for Embedded Applications
Directory of Open Access Journals (Sweden)
Gyorgy Petruska
2007-02-01
Full Text Available Many new small and fast pseudorandom number generators are presented, which pass the most common randomness tests. They perform only a few, nonmultiplicative operations for each generated number, use very little memory, therefore, they are ideal for embedded applications. We present general methods to ensure very long cycles and show, how to create super fast, very small ciphers and hash functions from them.
The estimation of the catchment runoff using a small number of ...
African Journals Online (AJOL)
The estimation of the catchment runoff using a small number of rainfall stations in Burkina Faso. Youssouf Dembele, Jean Duchesne. Abstract. The objective of this study was to determine a suitable method to compute the runoff over a catchment with a few number of rainfall stations. Input hydrological variables were ...
Pictorial Cross-Currents between Hawthorne and Atwood: Negotiating with the Dead
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Patricia Simonson
2015-06-01
Full Text Available This paper analyzes the way in which a contemporary Canadian novelist, Margaret Atwood, uses the work of a canonical nineteenth-century American novelist, Nathaniel Hawthorne, to define her own position as a writer, while at the same time criticizing and transforming her precursor’s reflection on the writer’s task. I identify this process in Atwood’s 1996 novel, Alias Grace: it takes the form of a rewriting of Hawthorne’s most famous novel, The Scarlet Letter. An important connection between the two writers is their common use of visual art to pose, and potentially to resolve, the problems they encounter as artists in a hostile environment. Este artículo analiza cómo una novelista canadiense contemporánea, Margaret Atwood, utiliza la obra de un novelista norteamericano del siglo diecinueve, Nathaniel Hawthorne, para definir su propia posición como escritora, y también para criticar y transformar la reflexión de su predecesor. Este proceso se da en una novela de 1996, Alias Grace, en forma de una reescritura de la novela más famosa de Hawthorne, La letra escarlata. Una conexión importante entre los dos escritores es su uso del arte visual para plantear, y posiblemente resolver, los problemas que encuentran como artistas en un entorno hostil.
“I am a place”: Aletheia as aesthetic and political resistance in Margaret Atwood's Surfacing
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Joakim Wrethed
2015-07-01
Full Text Available The article investigates the aesthetic and political power of Margaret Atwood's 1972 novel Surfacing. It argues that the novel's perennial vitality is partly explained by Jacques Rancière's theory about the aesthetic regime of art that highlights the tension between art for art's sake and art as a political instrument. By means of phenomenological methodology and concepts, mainly derived from Martin Heidegger and Maurice Merleau-Ponty, the examination uncovers an experiential aesthetics intimately intertwined with the protagonist's perceptions throughout the narrative. These perceptions and impressions are permeated by a sense of semi-religious revelation. But here they are primarily seen from an epistemological perspective through the dominance of immediacy (denoted by the Greek aletheia over verificational dimensions (denoted by the Roman veritas. These predominantly sensory aspects of Surfacing make up the aesthetic nerve that is linked to the political impact of the work. Aletheia functions as a promise of emancipation since it transcends the political division of the sensory, that is, art for art's sake and art as life. But, Atwood's work also upholds this separation since aletheia is ultimately autonomous, which in turn sustains the autonomy of the novel. It is claimed that the persistent status of Surfacing—and thereby its sustained political impact—is ultimately due to its aesthetic integrity. The novel's more explicit political concerns of ecocriticism and feminism are secondary in relation to the force of aletheia.
Ratio dependence in small number discrimination is affected by the experimental procedure
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Christian eAgrillo
2015-10-01
Full Text Available Adults, infants and some non-human animals share an approximate number system (ANS to estimate numerical quantities, and are supposed to share a second, ‘object-tracking’, system (OTS that supports the precise representation of a small number of items (up to 3 or 4. In relative numerosity judgments, accuracy depends on the ratio of the two numerosities (Weber’s Law, for numerosities > 4 (the typical ANS range, while for numerosities ≤ 4 (OTS range there is usually no ratio effect. However, recent studies have found evidence for ratio effects for small numerosities, challenging the idea that the OTS might be involved for small number discrimination. Here we tested the hypothesis that the lack of ratio effect in the numbers 1-4 is largely dependent on the type of stimulus presentation.We investigated relative numerosity judgments in college students using three different procedures: a simultaneous presentation of intermingled and separate groups of dots in separate experiments, and a further experiment with sequential presentation. As predicted, in the large number range, ratio dependence was observed in all tasks. By contrast, in the small number range, ratio insensitivity was found in one task (sequential presentation. In a fourth experiment, we showed that the presence of intermingled distractors elicited a ratio effect, while easily distinguishable distractors did not. As the different ratio sensitivity for small and large numbers has been often interpreted in terms of the activation of the OTS and ANS, our results suggest that numbers 1-4 may be represented by both numerical systems and that the experimental context, such as the presence/absence of task-irrelevant items in the visual field, would determine which system is activated.
Impact on Dietary Intake of Removable Partial Dentures Replacing a Small Number of Teeth.
Inomata, Chisato; Ikebe, Kazunori; Okada, Tadashi; Takeshita, Hajime; Maeda, Yoshinobu
2015-01-01
The aim of this study was to clarify the impact of wearing removable partial dentures (RPDs) replacing a small number of teeth on dietary intake. Participants had at least 20 teeth and were classified as Eichner B1 or B2. The participants underwent dental and oral examinations, and their dietary intake was assessed. Analysis of covariance showed that RPD wearers consumed more vegetables, n-3 fatty acids, calcium, vitamin A, and dietary fiber than nonwearers after adjusting for possible confounding factors. It is concluded that RPDs are effective for improving dietary intake even in participants who have lost a small number of teeth.
Fuller, Nathaniel J.; Licata, Nicholas A.
2018-05-01
Obtaining a detailed understanding of the physical interactions between a cell and its environment often requires information about the flow of fluid surrounding the cell. Cells must be able to effectively absorb and discard material in order to survive. Strategies for nutrient acquisition and toxin disposal, which have been evolutionarily selected for their efficacy, should reflect knowledge of the physics underlying this mass transport problem. Motivated by these considerations, in this paper we discuss the results from an undergraduate research project on the advection-diffusion equation at small Reynolds number and large Péclet number. In particular, we consider the problem of mass transport for a Stokesian spherical swimmer. We approach the problem numerically and analytically through a rescaling of the concentration boundary layer. A biophysically motivated first-passage problem for the absorption of material by the swimming cell demonstrates quantitative agreement between the numerical and analytical approaches. We conclude by discussing the connections between our results and the design of smart toxin disposal systems.
van Leeuwen, E B; van der Veen, A Y; Hoekstra, D; Engberts, J B; Halie, M R; van der Meer, J; Ruiters, M H
OBJECTIVES: This study compared the efficiency of electroporation and synthetic amphiphiles. (SAINT-2pp/DOPE) in transfecting small numbers of human endothelial cells. METHODS AND RESULTS: Optimal transfection conditions were tested and appeared to be 400 V and 960 microF for electroporation and a
Runoff curve numbers for 10 small forested watersheds in the mountains of the eastern United States
Negussie H. Tedela; Steven C. McCutcheon; Todd C. Rasmussen; Richard H. Hawkins; Wayne T. Swank; John L. Campbell; Mary Beth Adams; C. Rhett Jackson; Ernest W. Tollner
2012-01-01
Engineers and hydrologists use the curve number method to estimate runoff from rainfall for different land use and soil conditions; however, large uncertainties occur for estimates from forested watersheds. This investigation evaluates the accuracy and consistency of the method using rainfall-runoff series from 10 small forested-mountainous watersheds in the eastern...
Gravitational sedimentation of cloud of solid spherical particles at small Reynolds numbers
Directory of Open Access Journals (Sweden)
Arkhipov Vladimir
2015-01-01
Full Text Available The experimental results of study of gravitational sedimentation of highly-concentrated systems of solid spherical particles at small Reynolds numbers Re<1 are presented. Empirical equation for drag coefficient of the particle assembly has been obtained. The influence of initial particle concentration in the cloud on its dynamics and velocity has been analysed.
Angular velocity of a spheroid log rolling in a simple shear at small Reynolds number
Meibohm, Jan; Candelier, Fabien; Rosen, Tomas; Einarsson, Jonas; Lundell, Fredrik; Mehlig, Bernhard
2016-11-01
We analyse the angular velocity of a small neutrally buoyant spheroid log rolling in a simple shear. When the effect of fluid inertia is negligible the angular velocity ω -> equals half the fluid vorticity. We compute by singular perturbation theory how weak fluid inertia reduces the angular velocity in an unbounded shear, and how this reduction depends upon the shape of the spheroid (on its aspect ratio). In addition we determine the angular velocity by direct numerical simulations. The results are in excellent agreement with the theory at small but not too small values of the shear Reynolds number, for all aspect ratios considered. For the special case of a sphere we find ω / s = - 1 / 2 + 0 . 0540Re 3 / 2 where s is the shear rate and Re is the shear Reynolds number. This result differs from that derived by Lin et al. who obtained a numerical coefficient roughly three times larger.
Separation and reattachment in flows over asymmetric cavities at small Reynolds numbers
International Nuclear Information System (INIS)
Tavoularis, S.; Goldman, A.; Floryan, J.M.
1985-01-01
Recent experimental and analytical studies of flows at extremely small Reynolds numbers have revealed rather complicated flow patterns, often beyond intuitive explanation. Such flows are common in biological systems as well as in industrial applications involving small particle suspensions. The present study was motivated by Nachtigall's observation that scales on certain butterfly and moth upper wing surfaces appear aerodynamically advantageous, since their removal results in decrease of the lift without an appreciable change of the drag. Since low Reynolds number flows are nearly reversible, it seems that geometrical asymmetry and not random roughness is responsible for this effect. Stokes flows (i.e. at 'zero' Reynolds number) are known to separate behind steps and obstacles, contrary to the expectation that the fluid motion would follow the boundary shape, if its inertia became negligible. (author)
Numerical Test of Analytical Theories for Perpendicular Diffusion in Small Kubo Number Turbulence
Energy Technology Data Exchange (ETDEWEB)
Heusen, M.; Shalchi, A., E-mail: husseinm@myumanitoba.ca, E-mail: andreasm4@yahoo.com [Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB R3T 2N2 (Canada)
2017-04-20
In the literature, one can find various analytical theories for perpendicular diffusion of energetic particles interacting with magnetic turbulence. Besides quasi-linear theory, there are different versions of the nonlinear guiding center (NLGC) theory and the unified nonlinear transport (UNLT) theory. For turbulence with high Kubo numbers, such as two-dimensional turbulence or noisy reduced magnetohydrodynamic turbulence, the aforementioned nonlinear theories provide similar results. For slab and small Kubo number turbulence, however, this is not the case. In the current paper, we compare different linear and nonlinear theories with each other and test-particle simulations for a noisy slab model corresponding to small Kubo number turbulence. We show that UNLT theory agrees very well with all performed test-particle simulations. In the limit of long parallel mean free paths, the perpendicular mean free path approaches asymptotically the quasi-linear limit as predicted by the UNLT theory. For short parallel mean free paths we find a Rechester and Rosenbluth type of scaling as predicted by UNLT theory as well. The original NLGC theory disagrees with all performed simulations regardless what the parallel mean free path is. The random ballistic interpretation of the NLGC theory agrees much better with the simulations, but compared to UNLT theory the agreement is inferior. We conclude that for this type of small Kubo number turbulence, only the latter theory allows for an accurate description of perpendicular diffusion.
Numerical Test of Analytical Theories for Perpendicular Diffusion in Small Kubo Number Turbulence
International Nuclear Information System (INIS)
Heusen, M.; Shalchi, A.
2017-01-01
In the literature, one can find various analytical theories for perpendicular diffusion of energetic particles interacting with magnetic turbulence. Besides quasi-linear theory, there are different versions of the nonlinear guiding center (NLGC) theory and the unified nonlinear transport (UNLT) theory. For turbulence with high Kubo numbers, such as two-dimensional turbulence or noisy reduced magnetohydrodynamic turbulence, the aforementioned nonlinear theories provide similar results. For slab and small Kubo number turbulence, however, this is not the case. In the current paper, we compare different linear and nonlinear theories with each other and test-particle simulations for a noisy slab model corresponding to small Kubo number turbulence. We show that UNLT theory agrees very well with all performed test-particle simulations. In the limit of long parallel mean free paths, the perpendicular mean free path approaches asymptotically the quasi-linear limit as predicted by the UNLT theory. For short parallel mean free paths we find a Rechester and Rosenbluth type of scaling as predicted by UNLT theory as well. The original NLGC theory disagrees with all performed simulations regardless what the parallel mean free path is. The random ballistic interpretation of the NLGC theory agrees much better with the simulations, but compared to UNLT theory the agreement is inferior. We conclude that for this type of small Kubo number turbulence, only the latter theory allows for an accurate description of perpendicular diffusion.
International Nuclear Information System (INIS)
Karger, C.P.; Hartmann, G.H.
2001-01-01
Background: Dose response experiments aim to determine the complication probability as a function of dose. Adjusting the parameters of the frequently used dose response model P(D)=1/[1+(D 50 /D) k ] to the experimental data, 2 intuitive quantities are obtained: The tolerance dose D 50 and the slope parameter k. For mathematical reasons, however, standard statistic software uses a different set of parameters. Therefore, the resulting fit parameters of the statistic software as well as their standard errors have to be transformed to obtain D 50 and k as well as their standard errors. Material and Methods: The influence of the number of dose levels on the uncertainty of the fit parameters is studied by a simulation for a fixed number of animals. For experiments with small animal numbers, statistical artifacts may prevent the determination of the standard errors of the fit parameters. Consequences on the design of dose response experiments are investigated. Results: Explicit formulas are presented, which allow to calculate the parameters D 50 and k as well as their standard errors from the output of standard statistic software. The simulation shows, that the standard errors of the resulting parameters are independent of the number of dose levels, as long as the total number of animals involved in the experiment, remains constant. Conclusion: Statistical artifacts in experiments containing small animal numbers may be prevented by an adequate design of the experiment. For this, it is suggested to select a higher number of dose levels, rather than using a higher number of animals per dose level. (orig.) [de
Sphalerons, small fluctuations, and baryon-number violation in electroweak theory
International Nuclear Information System (INIS)
Arnold, P.; McLerran, L.
1987-01-01
We study the formalism of the sphaleron approximation to baryon-number violation in the standard model at temperatures near 1 TeV. We investigate small fluctuations of the sphaleron, the competition of large-scale sphalerons with thermal fluctuations, and the damping of the transition rate in the plasma. We find a suppression of the rate due to Landau damping and due to factors arising from zero modes. Our approximations are valid in the regime 2M/sub W/(T) 2 . We find that the rate of baryon-number violation is still significantly larger than the expansion rate of the Universe
Neutrino masses, leptogenesis and dark matter from small lepton number violation?
Energy Technology Data Exchange (ETDEWEB)
Abada, Asmaa [CNRS, Univ. Paris-Sud, Univ. Paris-Saclay, Orsay (France). Lab. de Physique Theorique; Arcadi, Giorgio [Max Planck Institut fuer Kernphysik, Heidelberg (Germany); Domcke, Valerie [Paris Diderot Univ. (France). AstroParticule et Cosmologie (APC)/Paris Centre for Cosmological Physics (PCCP); Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Lucente, Michele [Univ. Catholique de Louvain, Louvain-la-Neuve (Belgium). Centre for Cosmology, Particle Physics and Phenomenology (CP3)
2017-09-05
We consider the possibility of simultaneously addressing the baryon asymmetry of the Universe, the dark matter problem and the neutrino mass generation in minimal extensions of the Standard Model via sterile fermions with (small) total lepton number violation. Within the framework of Inverse and Linear Seesaw models, the small lepton number violating parameters set the mass scale of the active neutrinos, the efficiency of leptogenesis through a small mass splitting between pairs of sterile fermions as well as the mass scale of a sterile neutrino dark matter candidate. We provide an improved parametrization of these seesaw models taking into account existing experimental constraints and derive a linearized system of Boltzmann equations to describe the leptogenesis process, which allows for an efficient investigation of the parameter space. This in particular enables us to perform a systematic study of the strong washout regime of leptogenesis. Our study reveals that one can have a successful leptogenesis at the temperature of the electroweak scale through oscillations between two sterile states with a natural origin of the (necessary) strong degeneracy in their mass spectrum. The minimal model however requires a non-standard cosmological history to account for the relic dark matter. Finally, we discuss the prospect for neutrinoless double beta decay and for testing, in future experiments, the values of mass and different active-sterile mixings required for successful leptogenesis.
Neutrino masses, leptogenesis and dark matter from small lepton number violation?
International Nuclear Information System (INIS)
Abada, Asmaa; Domcke, Valerie; Lucente, Michele
2017-01-01
We consider the possibility of simultaneously addressing the baryon asymmetry of the Universe, the dark matter problem and the neutrino mass generation in minimal extensions of the Standard Model via sterile fermions with (small) total lepton number violation. Within the framework of Inverse and Linear Seesaw models, the small lepton number violating parameters set the mass scale of the active neutrinos, the efficiency of leptogenesis through a small mass splitting between pairs of sterile fermions as well as the mass scale of a sterile neutrino dark matter candidate. We provide an improved parametrization of these seesaw models taking into account existing experimental constraints and derive a linearized system of Boltzmann equations to describe the leptogenesis process, which allows for an efficient investigation of the parameter space. This in particular enables us to perform a systematic study of the strong washout regime of leptogenesis. Our study reveals that one can have a successful leptogenesis at the temperature of the electroweak scale through oscillations between two sterile states with a natural origin of the (necessary) strong degeneracy in their mass spectrum. The minimal model however requires a non-standard cosmological history to account for the relic dark matter. Finally, we discuss the prospect for neutrinoless double beta decay and for testing, in future experiments, the values of mass and different active-sterile mixings required for successful leptogenesis.
Neutrino masses, leptogenesis and dark matter from small lepton number violation?
Abada, Asmaa; Arcadi, Giorgio; Domcke, Valerie; Lucente, Michele
2017-12-01
We consider the possibility of simultaneously addressing the baryon asymmetry of the Universe, the dark matter problem and the neutrino mass generation in minimal extensions of the Standard Model via sterile fermions with (small) total lepton number violation. Within the framework of Inverse and Linear Seesaw models, the small lepton number violating parameters set the mass scale of the active neutrinos, the efficiency of leptogenesis through a small mass splitting between pairs of sterile fermions as well as the mass scale of a sterile neutrino dark matter candidate. We provide an improved parametrization of these seesaw models taking into account existing experimental constraints and derive a linearized system of Boltzmann equations to describe the leptogenesis process, which allows for an efficient investigation of the parameter space. This in particular enables us to perform a systematic study of the strong washout regime of leptogenesis. Our study reveals that one can have a successful leptogenesis at the temperature of the electroweak scale through oscillations between two sterile states with a natural origin of the (necessary) strong degeneracy in their mass spectrum. The minimal model however requires a non-standard cosmological history to account for the relic dark matter. Finally, we discuss the prospect for neutrinoless double beta decay and for testing, in future experiments, the values of mass and different active-sterile mixings required for successful leptogenesis.
An analytical approach to estimate the number of small scatterers in 2D inverse scattering problems
International Nuclear Information System (INIS)
Fazli, Roohallah; Nakhkash, Mansor
2012-01-01
This paper presents an analytical method to estimate the location and number of actual small targets in 2D inverse scattering problems. This method is motivated from the exact maximum likelihood estimation of signal parameters in white Gaussian noise for the linear data model. In the first stage, the method uses the MUSIC algorithm to acquire all possible target locations and in the next stage, it employs an analytical formula that works as a spatial filter to determine which target locations are associated to the actual ones. The ability of the method is examined for both the Born and multiple scattering cases and for the cases of well-resolved and non-resolved targets. Many numerical simulations using both the coincident and non-coincident arrays demonstrate that the proposed method can detect the number of actual targets even in the case of very noisy data and when the targets are closely located. Using the experimental microwave data sets, we further show that this method is successful in specifying the number of small inclusions. (paper)
Diffusion of test particles in stochastic magnetic fields for small Kubo numbers
International Nuclear Information System (INIS)
Neuer, Marcus; Spatschek, Karl H.
2006-01-01
Motion of charged particles in a collisional plasma with stochastic magnetic field lines is investigated on the basis of the so-called A-Langevin equation. Compared to the previously used V-Langevin model, here finite Larmor radius effects are taken into account. The A-Langevin equation is solved under the assumption that the Lagrangian correlation function for the magnetic field fluctuations is related to the Eulerian correlation function (in Gaussian form) via the Corrsin approximation. The latter is justified for small Kubo numbers. The velocity correlation function, being averaged with respect to the stochastic variables including collisions, leads to an implicit differential equation for the mean square displacement. From the latter, different transport regimes, including the well-known Rechester-Rosenbluth diffusion coefficient, are derived. Finite Larmor radius contributions show a decrease of the diffusion coefficient compared to the guiding center limit. The case of small (or vanishing) mean fields is also discussed
Costa, Sofia R; Kerry, Brian R; Bardgett, Richard D; Davies, Keith G
2006-12-01
The Pasteuria group of endospore-forming bacteria has been studied as a biocontrol agent of plant-parasitic nematodes. Techniques have been developed for its detection and quantification in soil samples, and these mainly focus on observations of endospore attachment to nematodes. Characterization of Pasteuria populations has recently been performed with DNA-based techniques, which usually require the extraction of large numbers of spores. We describe a simple immunological method for the quantification and characterization of Pasteuria populations. Bayesian statistics were used to determine an extraction efficiency of 43% and a threshold of detection of 210 endospores g(-1) sand. This provided a robust means of estimating numbers of endospores in small-volume samples from a natural system. Based on visual assessment of endospore fluorescence, a quantitative method was developed to characterize endospore populations, which were shown to vary according to their host.
Determination of Curve Number for snowmelt-runoff floods in a small catchment
Directory of Open Access Journals (Sweden)
L. Hejduk
2015-06-01
Full Text Available One of the widely used methods for predicting flood runoff depth from ungauged catchments is the curve number (CN method, developed by Soil Conservation Service (SCS of US Department of Agriculture. The CN parameter can be computed directly from recorded rainfall depths and direct runoff volumes in case of existing data. In presented investigations, the CN parameter has been computed for snowmelt-runoff events based on snowmelt and rainfall measurements. All required data has been gathered for a small agricultural catchment (A = 23.4 km2 of Zagożdżonka river, located in Central Poland. The CN number received from 28 snowmelt-runoff events has been compared with CN computed from rainfall-runoff events for the same catchment. The CN parameter, estimated empirically varies from 64.0 to 94.8. The relation between CN and snowmelt depth was investigated in a similar procedure to relation between CN and rainfall depth.
Angular velocity of a sphere in a simple shear at small Reynolds number
Meibohm, J.; Candelier, F.; Rosén, T.; Einarsson, J.; Lundell, F.; Mehlig, B.
2016-12-01
We analyze the angular velocity of a small neutrally buoyant spheroid log rolling in a simple shear. When the effect of fluid inertia is negligible the angular velocity ω equals half the fluid vorticity. We compute by singular perturbation theory how weak fluid inertia reduces the angular velocity in an unbounded shear, and how this reduction depends upon the shape of the spheroid (on its aspect ratio). In addition we determine the angular velocity by direct numerical simulations. The results are in excellent agreement with the theory at small but not too small values of the shear Reynolds number Res, for all aspect ratios considered. For the special case of a sphere we find ω /s =-1 /2 +0.0540 Res3 /2 where s is the shear rate. The O (Res3 /2) correction differs from that derived by Lin et al. [J. Fluid Mech. 44, 1 (1970), 10.1017/S0022112070001659], who obtained a numerical coefficient roughly three times larger.
Small area estimation for estimating the number of infant mortality in West Java, Indonesia
Anggreyani, Arie; Indahwati, Kurnia, Anang
2016-02-01
Demographic and Health Survey Indonesia (DHSI) is a national designed survey to provide information regarding birth rate, mortality rate, family planning and health. DHSI was conducted by BPS in cooperation with National Population and Family Planning Institution (BKKBN), Indonesia Ministry of Health (KEMENKES) and USAID. Based on the publication of DHSI 2012, the infant mortality rate for a period of five years before survey conducted is 32 for 1000 birth lives. In this paper, Small Area Estimation (SAE) is used to estimate the number of infant mortality in districts of West Java. SAE is a special model of Generalized Linear Mixed Models (GLMM). In this case, the incidence of infant mortality is a Poisson distribution which has equdispersion assumption. The methods to handle overdispersion are binomial negative and quasi-likelihood model. Based on the results of analysis, quasi-likelihood model is the best model to overcome overdispersion problem. The basic model of the small area estimation used basic area level model. Mean square error (MSE) which based on resampling method is used to measure the accuracy of small area estimates.
Measuring gamma at LHCb with an Atwood-Dunietz-Soni Method
Patel, M
2006-01-01
The selection efficiencies and backgrounds for the two-body Atwood-Dunietz-Soni modes B+- -> D0bar/D0 K+-, where the D0bar/D0 decays to Kpi, KK or pipi, are determined from studies with LHCb's full GEANT based Monte Carlo simulation. These are used with a toy Monte Carlo, and assumptions about the D0bar/D0 -> Kpipipi decay modes, to estimate the precision with which LHCb will be able to measure the CKM angle gamma. For the majority of values of the unknown strong phases in the relevant D0bar/D0 decays, the fits to the toy Monte Carlo data converge and return the input values. Depending on the values of these phases, the precision on gamma from a nominal year of data (2fb-1 integrated luminosity) is in the range 2-6 degrees without the background, and 5-13 degrees with the considered background. In the latter case the background estimate is statistically limited and has a large uncertainty.
Oscillatory activity in the infant brain and the representation of small numbers
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Sumie eLeung
2016-02-01
Full Text Available Gamma-band oscillatory activity (GBA is an established neural signature of sustained occluded object representation in infants and adults. However, it is not yet known whether the magnitude of GBA in the infant brain reflects the quantity of occluded items held in memory. To examine this, we compared GBA of 6- to 8-month-old infants during occlusion periods after the representation of two objects versus that of one object. We found that maintaining a representation of two objects during occlusion resulted in significantly greater GBA relative to maintaining a single object. Further, this enhancement was located in the right occipital region, which is consistent with previous object representation research in adults and infants. We conclude that enhanced GBA reflects neural processes underlying infants’ representation of small numbers.
Oscillatory Activity in the Infant Brain and the Representation of Small Numbers.
Leung, Sumie; Mareschal, Denis; Rowsell, Renee; Simpson, David; Iaria, Leon; Grbic, Amanda; Kaufman, Jordy
2016-01-01
Gamma-band oscillatory activity (GBA) is an established neural signature of sustained occluded object representation in infants and adults. However, it is not yet known whether the magnitude of GBA in the infant brain reflects the quantity of occluded items held in memory. To examine this, we compared GBA of 6-8 month-old infants during occlusion periods after the representation of two objects vs. that of one object. We found that maintaining a representation of two objects during occlusion resulted in significantly greater GBA relative to maintaining a single object. Further, this enhancement was located in the right occipital region, which is consistent with previous object representation research in adults and infants. We conclude that enhanced GBA reflects neural processes underlying infants' representation of small numbers.
A small number of abnormal brain connections predicts adult autism spectrum disorder.
Yahata, Noriaki; Morimoto, Jun; Hashimoto, Ryuichiro; Lisi, Giuseppe; Shibata, Kazuhisa; Kawakubo, Yuki; Kuwabara, Hitoshi; Kuroda, Miho; Yamada, Takashi; Megumi, Fukuda; Imamizu, Hiroshi; Náñez, José E; Takahashi, Hidehiko; Okamoto, Yasumasa; Kasai, Kiyoto; Kato, Nobumasa; Sasaki, Yuka; Watanabe, Takeo; Kawato, Mitsuo
2016-04-14
Although autism spectrum disorder (ASD) is a serious lifelong condition, its underlying neural mechanism remains unclear. Recently, neuroimaging-based classifiers for ASD and typically developed (TD) individuals were developed to identify the abnormality of functional connections (FCs). Due to over-fitting and interferential effects of varying measurement conditions and demographic distributions, no classifiers have been strictly validated for independent cohorts. Here we overcome these difficulties by developing a novel machine-learning algorithm that identifies a small number of FCs that separates ASD versus TD. The classifier achieves high accuracy for a Japanese discovery cohort and demonstrates a remarkable degree of generalization for two independent validation cohorts in the USA and Japan. The developed ASD classifier does not distinguish individuals with major depressive disorder and attention-deficit hyperactivity disorder from their controls but moderately distinguishes patients with schizophrenia from their controls. The results leave open the viable possibility of exploring neuroimaging-based dimensions quantifying the multiple-disorder spectrum.
Curve Number Estimation for a Small Urban Catchment from Recorded Rainfall-Runoff Events
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Banasik Kazimierz
2014-12-01
Full Text Available Runoff estimation is a key component in various hydrological considerations. Estimation of storm runoff is especially important for the effective design of hydraulic and road structures, for the ﬂood ﬂow management, as well as for the analysis of land use changes, i.e. urbanization or low impact development of urban areas. The curve number (CN method, developed by Soil Conservation Service (SCS of the U.S. Department of Agriculture for predicting the ﬂood runoff depth from ungauged catchments, has been in continuous use for ca. 60 years. This method has not been extensively tested in Poland, especially in small urban catchments, because of lack of data. In this study, 39 rainfall-runoff events, collected during four years (2009–2012 in a small (A=28.7 km2, urban catchment of Służew Creek in southwest part of Warsaw were used, with the aim of determining the CNs and to check its applicability to ungauged urban areas. The parameters CN, estimated empirically, vary from 65.1 to 95.0, decreasing with rainfall size and, when sorted rainfall and runoff separately, reaching the value from 67 to 74 for large rainfall events.
On the continuum theory of the one-fluid solar wind for small Prandtl number
International Nuclear Information System (INIS)
Johnson, R.S.
1976-01-01
The continuum theory for a single-species gas expanding into a vacuum (or near vacuum) is considered. The gas is assumed compressible, viscous and heat conducting with a constant Prandtl number and viscosity proportional to (temperature) sup(ω), ω > 1. The gas is under the influence of a gravitational field centred on the Sun. For small Prandtl number (which is realistic for the one-fluid solar wind), the method of matched asymptotic expansions is used to construct a solution describing the complete flow field from the surface of the Sun to infinity. The first two regions correspond to those found by Roberts and Soward (Proc. R. Soc. Lond.; A328:185 (1972)) for large thermal conductivity; the next involves the viscous terms, and in the fourth the viscous terms dominate. It it shown from the fourth region that either the flow remains supersonic but terminates at a finite point, or the flow becomes subsonic through a diffuse shock layer and approaches a non-zero pressure at infinity. It is seen that the existence of a critical point (subsonic/supersonic transition) together with a known pressure at infinity can uniquely determine the complete solution. However, to correspond with typical results near the Sun and at the Earth's orbit the pressure at infinity is found to be very much larger than that generally accepted. (author)
Šimkanin, Ján; Kyselica, Juraj
2017-12-01
Numerical simulations of the geodynamo are becoming more realistic because of advances in computer technology. Here, the geodynamo model is investigated numerically at the extremely low Ekman and magnetic Prandtl numbers using the PARODY dynamo code. These parameters are more realistic than those used in previous numerical studies of the geodynamo. Our model is based on the Boussinesq approximation and the temperature gradient between upper and lower boundaries is a source of convection. This study attempts to answer the question how realistic the geodynamo models are. Numerical results show that our dynamo belongs to the strong-field dynamos. The generated magnetic field is dipolar and large-scale while convection is small-scale and sheet-like flows (plumes) are preferred to a columnar convection. Scales of magnetic and velocity fields are separated, which enables hydromagnetic dynamos to maintain the magnetic field at the low magnetic Prandtl numbers. The inner core rotation rate is lower than that in previous geodynamo models. On the other hand, dimensional magnitudes of velocity and magnetic fields and those of the magnetic and viscous dissipation are larger than those expected in the Earth's core due to our parameter range chosen.
Field emission characteristics of a small number of carbon fiber emitters
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Wilkin W. Tang
2016-09-01
Full Text Available This paper reports an experiment that studies the emission characteristics of small number of field emitters. The experiment consists of nine carbon fibers in a square configuration. Experimental results show that the emission characteristics depend strongly on the separation between each emitter, providing evidence of the electric field screening effects. Our results indicate that as the separation between the emitters decreases, the emission current for a given voltage also decreases. The authors compare the experimental results to four carbon fiber emitters in a linear and square configurations as well as to two carbon fiber emitters in a paired array. Voltage-current traces show that the turn-on voltage is always larger for the nine carbon fiber emitters as compared to the two and four emitters in linear configurations, and approximately identical to the four emitters in a square configuration. The observations and analysis reported here, based on Fowler-Nordheim field emission theory, suggest the electric field screening effect depends critically on the number of emitters, the separation between them, and their overall geometric configuration.
Celebi, M.
2006-01-01
An integrated seismic monitoring system with a total of 53 channels of accelerometers is now operating in and at the nearby free-field site of the 20-story steel-framed Atwood Building in highly seismic Anchorage, Alaska. The building has a single-story basement and a reinforced concrete foundation without piles. The monitoring system comprises a 32-channel structural array and a 21-channel site array. Accelerometers are deployed on 10 levels of the building to assess translational, torsional, and rocking motions, interstory drift (displacement) between selected pairs of adjacent floors, and average drift between floors. The site array, located approximately a city block from the building, comprises seven triaxial accelerometers, one at the surface and six in boreholes ranging in depths from 15 to 200 feet (???5-60 meters). The arrays have already recorded low-amplitude shaking responses of the building and the site caused by numerous earthquakes at distances ranging from tens to a couple of hundred kilometers. Data from an earthquake that occurred 186 km away traces the propagation of waves from the deepest borehole to the roof of the building in approximately 0.5 seconds. Fundamental structural frequencies [0.58 Hz (NS) and 0.47 Hz (EW)], low damping percentages (2-4%), mode coupling, and beating effects are identified. The fundamental site frequency at approximately 1.5 Hz is close to the second modal frequencies (1.83 Hz NS and 1.43 EW) of the building, which may cause resonance of the building. Additional earthquakes prove repeatability of these characteristics; however, stronger shaking may alter these conclusions. ?? 2006, Earthquake Engineering Research Institute.
Entropy Analyses of Droplet Combustion in Convective Environment with Small Reynolds Number
Institute of Scientific and Technical Information of China (English)
ZHANG Xiaobin; ZHANG Wei; ZHANG Xuejun
2013-01-01
This paper analyzes the entropy generation rate of simple pure droplet combustion in a temperature-elevated air convective environment based on the solutions of flow,and heat and mass transfer between the two phases.The flow-field calculations are carried out by solving the respective conservation equations for each phase,accounting for the droplet deformation with the axisymmetric model.The effects of the temperature,velocity and oxygen fraction of the free stream air on the total entropy generation rate in the process of the droplet combustion are investigated.Special attention is given to analyze the quantitative effects of droplet deformation.The results reveal that the entropy generation rate due to chemical reaction occupies a large fraction of the total entropy generated,as a result of the large areas covered by the flame.Although,the magnitude of the entropy generation rate per volume due to heat transfer and combined mass and heat transfer has a magnitude of one order greater than that due to chemical reaction,they cover a very limited area,leading to a small fraction of the total entropy generated.The entropy generation rate due to mass transfer is negligible.High temperature and high velocity of the free stream are advantageous to increase the exergy efficiency in the range of small Reynolds number (＜1) from the viewpoint of the second-law analysis over the droplet lifetime.The effect of droplet deformation on the total entropy generation is the modest.
Directory of Open Access Journals (Sweden)
Marion Hoehn
Full Text Available The effective population size (N(e is proportional to the loss of genetic diversity and the rate of inbreeding, and its accurate estimation is crucial for the monitoring of small populations. Here, we integrate temporal studies of the gecko Oedura reticulata, to compare genetic and demographic estimators of N(e. Because geckos have overlapping generations, our goal was to demographically estimate N(bI, the inbreeding effective number of breeders and to calculate the N(bI/N(a ratio (N(a =number of adults for four populations. Demographically estimated N(bI ranged from 1 to 65 individuals. The mean reduction in the effective number of breeders relative to census size (N(bI/N(a was 0.1 to 1.1. We identified the variance in reproductive success as the most important variable contributing to reduction of this ratio. We used four methods to estimate the genetic based inbreeding effective number of breeders N(bI(gen and the variance effective populations size N(eV(gen estimates from the genotype data. Two of these methods - a temporal moment-based (MBT and a likelihood-based approach (TM3 require at least two samples in time, while the other two were single-sample estimators - the linkage disequilibrium method with bias correction LDNe and the program ONeSAMP. The genetic based estimates were fairly similar across methods and also similar to the demographic estimates excluding those estimates, in which upper confidence interval boundaries were uninformative. For example, LDNe and ONeSAMP estimates ranged from 14-55 and 24-48 individuals, respectively. However, temporal methods suffered from a large variation in confidence intervals and concerns about the prior information. We conclude that the single-sample estimators are an acceptable short-cut to estimate N(bI for species such as geckos and will be of great importance for the monitoring of species in fragmented landscapes.
Analysis of gene expression in small numbers of purified hemopoietic progenitor cells by RT-PCR.
Ziegler, B L; Lamping, C P; Thoma, S J; Fliedner, T M
1995-05-01
Primitive hemopoietic stem cells represent the most probable targets for genetic alterations due to exposure to ionizing irradiation or chemical carcinogens. We have applied a two-step protocol for the purification of CD34+HLA-DR-/low hemopoietic progenitor cells from cord blood (CB). CD34+ cells were isolated by monoclonal antibody (mAb) against CD34 (My10) and immunomagnetic beads. Beads were cleaved off the CD34+ cells by enzymatic treatment with chymopapain. Due to chymopapain-resistance of epitopes recognized by the used mAbs purity control of CD34+ cells and separation into CD34+HLA-DR-/low and CD34+HLA-DR+ subsets could be performed by using flow cytometry. Two miniaturized procedures were applied to isolate poly(A)+ mRNA for the reverse transcription polymerase chain reaction (RT-PCR) from small numbers of CD34+HLA-DR-/low cells. In five experiments, the mean purity of immunomagnetically isolated CD34+ cells was 93.8% +/- 3.9. Flow cytometry sorting of CD34+ cells resulted in pure CD34+HLA-DR-/low populations (purity > 98.8%; range 98.8% to 99.9%; viability > 96%) with an average yield of 2600 +/- 800 cells/5 x 10(7) low density CB cells. By RT-PCR using both poly(A)+ mRNA isolation procedures, sequences corresponding to CD34 and beta 2-microglobulin were amplified from as few as 20 cells. Furthermore, a sequence-independent RT-PCR (SIP-RT-PCR) was applied to amplify the cDNA derived from five erythroblasts isolated from a burst-forming unit-erythroid (BFU-E). Upon hybridization, full-length c-fos message was detected in the SIP-RT-PCR amplified material. Our data demonstrate that gene expression can be detected at the transcriptional level in small numbers of hemopoietic progenitor cells. In addition, the SIP-RT-PCR may allow the amplification of unique mRNA species when subtractive hybridization procedures are performed. The presented data should be useful to analyze gene expression in rare subsets of radiation-exposed immature hemopoietic stem
CRISPR transcript processing: a mechanism for generating a large number of small interfering RNAs
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Djordjevic Marko
2012-07-01
Full Text Available Abstract Background CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated sequences is a recently discovered prokaryotic defense system against foreign DNA, including viruses and plasmids. CRISPR cassette is transcribed as a continuous transcript (pre-crRNA, which is processed by Cas proteins into small RNA molecules (crRNAs that are responsible for defense against invading viruses. Experiments in E. coli report that overexpression of cas genes generates a large number of crRNAs, from only few pre-crRNAs. Results We here develop a minimal model of CRISPR processing, which we parameterize based on available experimental data. From the model, we show that the system can generate a large amount of crRNAs, based on only a small decrease in the amount of pre-crRNAs. The relationship between the decrease of pre-crRNAs and the increase of crRNAs corresponds to strong linear amplification. Interestingly, this strong amplification crucially depends on fast non-specific degradation of pre-crRNA by an unidentified nuclease. We show that overexpression of cas genes above a certain level does not result in further increase of crRNA, but that this saturation can be relieved if the rate of CRISPR transcription is increased. We furthermore show that a small increase of CRISPR transcription rate can substantially decrease the extent of cas gene activation necessary to achieve a desired amount of crRNA. Conclusions The simple mathematical model developed here is able to explain existing experimental observations on CRISPR transcript processing in Escherichia coli. The model shows that a competition between specific pre-crRNA processing and non-specific degradation determines the steady-state levels of crRNA and is responsible for strong linear amplification of crRNAs when cas genes are overexpressed. The model further shows how disappearance of only a few pre-crRNA molecules normally present in the cell can lead to a large (two
Klonsky, Michael
A compelling body of research shows that when students are part of smaller and more intimate learning communities, they are more successful. The latest research demonstrates that small schools, particularly schools of choice, have a measurably positive impact on inner-city students, especially those from minority and low-income families. The…
Detection of small number of Giardia in biological materials prepared from stray dogs.
Esmailikia, Leila; Ebrahimzade, Elahe; Shayan, Parviz; Amininia, Narges
2017-12-20
Giardia lamblia is an intestinal protozoa with intermittent and low shedding especially in dogs, and the detection of Giardia is accompanied with problems such as sampling and diagnostic method. The objective of this study was to detection of Giardia in biological materials with low number of parasite using parasitological and molecular methods, and also to determine whether the examined stray dogs harbor known zoonotic genotype of Giardia. For this aim 85 fecal and duodenal samples were studied from which 1 was positive by Trichrome staining of stool, 4 were positive by staining of duodenal samples. The nested PCR analysis with primers derived from 18 SrRNA showed that the specific PCR product could be amplified in 4 stool and 4 duodenal samples. All positive samples in staining analysis were also positive in nested PCR. No amplification could be observed by nested PCR with primers derived from β giardin gene due to the single copy of gene. Interestingly, the extracted DNA from old fixed stained Giardia positive smears could be also amplified with primers derived from 18SrRNA gene. The sequence analysis of nested PCR products showed that they belong to the genotype D. In conclusion, it is to denote that the Trichrome or Giemsa methods were not suitable for the detection of small number of this parasite in stool and the nested PCR with primers derived from 18S rRNA gene can replace the traditional methods successfully. For detection of Giardia in stool, primers derived from β giardin will not be recommended.
Retention and Curve Number Variability in a Small Agricultural Catchment: The Probabilistic Approach
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Kazimierz Banasik
2014-04-01
Full Text Available The variability of the curve number (CN and the retention parameter (S of the Soil Conservation Service (SCS-CN method in a small agricultural, lowland watershed (23.4 km2 to the gauging station in central Poland has been assessed using the probabilistic approach: distribution fitting and confidence intervals (CIs. Empirical CNs and Ss were computed directly from recorded rainfall depths and direct runoff volumes. Two measures of the goodness of fit were used as selection criteria in the identification of the parent distribution function. The measures specified the generalized extreme value (GEV, normal and general logistic (GLO distributions for 100-CN and GLO, lognormal and GEV distributions for S. The characteristics estimated from theoretical distribution (median, quantiles were compared to the tabulated CN and to the antecedent runoff conditions of Hawkins and Hjelmfelt. The distribution fitting for the whole sample revealed a good agreement between the tabulated CN and the median and between the antecedent runoff conditions (ARCs of Hawkins and Hjelmfelt, which certified a good calibration of the model. However, the division of the CN sample due to heavy and moderate rainfall depths revealed a serious inconsistency between the parameters mentioned. This analysis proves that the application of the SCS-CN method should rely on deep insight into the probabilistic properties of CN and S.
Anderson, Eric C; Ng, Thomas C
2016-02-01
We develop a computational framework for addressing pedigree inference problems using small numbers (80-400) of single nucleotide polymorphisms (SNPs). Our approach relaxes the assumptions, which are commonly made, that sampling is complete with respect to the pedigree and that there is no genotyping error. It relies on representing the inferred pedigree as a factor graph and invoking the Sum-Product algorithm to compute and store quantities that allow the joint probability of the data to be rapidly computed under a large class of rearrangements of the pedigree structure. This allows efficient MCMC sampling over the space of pedigrees, and, hence, Bayesian inference of pedigree structure. In this paper we restrict ourselves to inference of pedigrees without loops using SNPs assumed to be unlinked. We present the methodology in general for multigenerational inference, and we illustrate the method by applying it to the inference of full sibling groups in a large sample (n=1157) of Chinook salmon typed at 95 SNPs. The results show that our method provides a better point estimate and estimate of uncertainty than the currently best-available maximum-likelihood sibling reconstruction method. Extensions of this work to more complex scenarios are briefly discussed. Published by Elsevier Inc.
Designing an array for performing Near-field Acoustic Holography with a small number of p-u probes
DEFF Research Database (Denmark)
Fernandez Comesaña, Daniel; Wen, Junjie; Fernandez Grande, Efren
2016-01-01
, such approaches usually require that a large number of transducers is spatially distributed over the area of interest. This paper describes some practical considerations for the design and optimization of a compact sensor array for performing NAH with a small number of sound intensity p-u probes. Two sensor...
Seeck, James K.; Lucas, John A.
In 1988, a survey was conducted to determine the feasibility of offering a new degree credit program in Small Business Management at William Rainey Harper College, in Illinois. All 3,170 former students who had taken a non-credit seminar in the Small Business Department in Continuing Education were surveyed regarding their interest in small…
International Nuclear Information System (INIS)
Hashemi, Jamileh; Fotouhi, Omid; Sulaiman, Luqman; Kjellman, Magnus; Höög, Anders; Zedenius, Jan; Larsson, Catharina
2013-01-01
Small intestinal neuroendocrine tumors (SI-NETs) are typically slow-growing tumors that have metastasized already at the time of diagnosis. The purpose of the present study was to further refine and define regions of recurrent copy number (CN) alterations (CNA) in SI-NETs. Genome-wide CNAs was determined by applying array CGH (a-CGH) on SI-NETs including 18 primary tumors and 12 metastases. Quantitative PCR analysis (qPCR) was used to confirm CNAs detected by a-CGH as well as to detect CNAs in an extended panel of SI-NETs. Unsupervised hierarchical clustering was used to detect tumor groups with similar patterns of chromosomal alterations based on recurrent regions of CN loss or gain. The log rank test was used to calculate overall survival. Mann–Whitney U test or Fisher’s exact test were used to evaluate associations between tumor groups and recurrent CNAs or clinical parameters. The most frequent abnormality was loss of chromosome 18 observed in 70% of the cases. CN losses were also frequently found of chromosomes 11 (23%), 16 (20%), and 9 (20%), with regions of recurrent CN loss identified in 11q23.1-qter, 16q12.2-qter, 9pter-p13.2 and 9p13.1-11.2. Gains were most frequently detected in chromosomes 14 (43%), 20 (37%), 4 (27%), and 5 (23%) with recurrent regions of CN gain located to 14q11.2, 14q32.2-32.31, 20pter-p11.21, 20q11.1-11.21, 20q12-qter, 4 and 5. qPCR analysis confirmed most CNAs detected by a-CGH as well as revealed CNAs in an extended panel of SI-NETs. Unsupervised hierarchical clustering of recurrent regions of CNAs revealed two separate tumor groups and 5 chromosomal clusters. Loss of chromosomes 18, 16 and 11 and again of chromosome 20 were found in both tumor groups. Tumor group II was enriched for alterations in chromosome cluster-d, including gain of chromosomes 4, 5, 7, 14 and gain of 20 in chromosome cluster-b. Gain in 20pter-p11.21 was associated with short survival. Statistically significant differences were observed between primary
Energy Technology Data Exchange (ETDEWEB)
Kupavskii, A B; Raigorodskii, A M [M. V. Lomonosov Moscow State University, Faculty of Mechanics and Mathematics, Moscow (Russian Federation)
2013-10-31
We investigate in detail some properties of distance graphs constructed on the integer lattice. Such graphs find wide applications in problems of combinatorial geometry, in particular, such graphs were employed to answer Borsuk's question in the negative and to obtain exponential estimates for the chromatic number of the space. This work is devoted to the study of the number of cliques and the chromatic number of such graphs under certain conditions. Constructions of sequences of distance graphs are given, in which the graphs have unit length edges and contain a large number of triangles that lie on a sphere of radius 1/√3 (which is the minimum possible). At the same time, the chromatic numbers of the graphs depend exponentially on their dimension. The results of this work strengthen and generalize some of the results obtained in a series of papers devoted to related issues. Bibliography: 29 titles.
Bose-Einstein condensation of photons from the thermodynamic limit to small photon numbers
Nyman, Robert A.; Walker, Benjamin T.
2018-03-01
Photons can come to thermal equilibrium at room temperature by scattering multiple times from a fluorescent dye. By confining the light and dye in a microcavity, a minimum energy is set and the photons can then show Bose-Einstein condensation. We present here the physical principles underlying photon thermalization and condensation, and review the literature on the subject. We then explore the 'small' regime where very few photons are needed for condensation. We compare thermal equilibrium results to a rate-equation model of microlasers, which includes spontaneous emission into the cavity, and we note that small systems result in ambiguity in the definition of threshold.
An improved method for setting upper limits with small numbers of events
International Nuclear Information System (INIS)
Swartz, M.L.
1990-01-01
We note that most experimental searches for rare phenomena actually measure the ratio of the number of event candidates to the number of some normalizing events. These measurements are most naturally interpreted within the framework of binomial or trinomial statistics. We present a general expression, based upon a classical treatment, that accounts for statistical normalization errors and incorporates expected background rates. The solutions of this expression converge to the standard Poisson values when the number of normalizing events is larger than a few hundred. (orig.)
Haan, J.C.; Buffart, T.E.; Eijk, P.P.; van de Wiel, M.A.; van Wieringen, W.N.; Howdle, P.D.; Mulder, C.J.J.; van de Velde, CJ; Quirke, P.; Nagtegaal, I.D.; van Grieken, N.C.T.; Grabsch, H.; Meijer, G.A.; Ylstra, B.
2012-01-01
Background: Small bowel adenocarcinoma (SBA) is a rare cancer and consequently, the options for clinical trials are limited. As they are treated according to either a colorectal or a gastric cancer regimen and the molecular biology of a tumor is a pivotal determinant for therapy response,
Haan, J.C.; Buffart, T.E.; Eijk, P.P.; Wiel, M.A. van de; Wieringen, W.N. van; Howdle, P.D.; Mulder, C.J.; Velde, C.J. van de; Quirke, P.; Nagtegaal, I.D.; Grieken, N.C. van; Grabsch, H.; Meijer, G.A.; Ylstra, B.
2012-01-01
BACKGROUND: Small bowel adenocarcinoma (SBA) is a rare cancer and consequently, the options for clinical trials are limited. As they are treated according to either a colorectal or a gastric cancer regimen and the molecular biology of a tumor is a pivotal determinant for therapy response,
International Nuclear Information System (INIS)
Robison, R. F.
2010-01-01
To date no objective scientific medical biography has been published on Howard Atwood Kelly, one of America's foremost radium pioneers. He had become internationally known since 1889 as the founding Chief of the Gynecology Service at Johns Hopkins, well before the discovery of radium. He was also later to maintain his own hospital in Baltimore. He was a multifaceted man and his biography provides some fascinating reading about the treatment of gynaecological cancer in the USA at the end of the 19 th century and well into the 20 th century. An Appendix is included which contains extracts from Curtis Bumam's 1936 Janeway Memorial Lecture on 'Early Experiences with Radium' which was published (without quoting any references) in the American Journal of Roentgenology (AJR). Bumam was probably the most important of Kelly's collaborators and he provides unique personal and scientific insights on Kelly and the trials (and) tribulations of obtaining and using radium in 1911. (author)
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Michael Ramscar
Full Text Available Although number words are common in everyday speech, learning their meanings is an arduous, drawn-out process for most children, and the source of this delay has long been the subject of inquiry. Children begin by identifying the few small numerosities that can be named without counting, and this has prompted further debate over whether there is a specific, capacity-limited system for representing these small sets, or whether smaller and larger sets are both represented by the same system. Here we present a formal, computational analysis of number learning that offers a possible solution to both puzzles. This analysis indicates that once the environment and the representational demands of the task of learning to identify sets are taken into consideration, a continuous system for learning, representing and discriminating set-sizes can give rise to effective discontinuities in processing. At the same time, our simulations illustrate how typical prenominal linguistic constructions ("there are three balls" structure information in a way that is largely unhelpful for discrimination learning, while suggesting that postnominal constructions ("balls, there are three" will facilitate such learning. A training-experiment with three-year olds confirms these predictions, demonstrating that rapid, significant gains in numerical understanding and competence are possible given appropriately structured postnominal input. Our simulations and results reveal how discrimination learning tunes children's systems for representing small sets, and how its capacity-limits result naturally out of a mixture of the learning environment and the increasingly complex task of discriminating and representing ever-larger number sets. They also explain why children benefit so little from the training that parents and educators usually provide. Given the efficacy of our intervention, the ease with which it can be implemented, and the large body of research showing how early
Prediction uncertainty of plume characteristics derived from a small number of measuring points
French, H. K.; van der Zee, S. E. A. T. M.; Leijnse, A.
A small number of measuring points may inflict a bias on the characterisation of flow and transport based on field experiments in the unsaturated zone. Simulation of pure advective transport of a Gaussian plume through a setup of 30 regularly placed measuring points revealed regular temporal fluctuations about the real spatial moments. An irregular setup predicted both irregular fluctuations and larger discrepancies from the real value. From these considerations, a regular setup is recommended. Spatial moments were sensitive to the plume size relative to the distance between individual measuring points. To reduce prediction errors of the variance, the distance between the measuring points should be less than twice the standard deviation of the examined plume. The total size of the setup should cover several standard deviations of the plume to avoid mass being lost from the monitored area. Numerical simulations of a dispersing plume (comparing calculations based on 9000 nodes with 30 measuring points) revealed that vertical and horizontal centres of mass were predicted well at all degrees of heterogeneity, and the same was the case for horizontal variances. Vertical variances were more susceptible to prediction errors, but estimates were of the same order of magnitude as the real values. Résumé Lorsque l'on cherche à caractériser l'écoulement et le transport à partir d'expériences de terrain dans la zone saturée, il arrive qu'un petit nombre de points introduisent un biais. La simulation d'un transport purement advectif d'un panache gaussien au travers d'un ensemble de 30 points de mesures espacés régulièrement fait apparaître des variations temporelles régulières autour des moments spatiaux réels. Un ensemble irrégulier conduit à prédire à la fois des variations irrégulières et de plus grandes divergences par rapport à la valeur réelle. A partir de ces constations, un ensemble régulier est recommandé. Les moments spatiaux sont apparus
Kim, Christopher; Bassig, Bryan A; Seow, Wei Jie; Hu, Wei; Purdue, Mark P; Huang, Wen-Yi; Liu, Chin-San; Cheng, Wen-Ling; Männistö, Satu; Vermeulen, Roel; Weinstein, Stephanie J; Lim, Unhee; Hosgood, H Dean; Bonner, Matthew R; Caporaso, Neil E; Albanes, Demetrius; Lan, Qing; Rothman, Nathaniel
BACKGROUND: Mitochondrial DNA copy number (mtDNA CN) may be modified by mitochondria in response to oxidative stress. Previously, mtDNA CN was associated with non-Hodgkin lymphoma (NHL) risk, particularly chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). We conducted a replication
Small-number statistics near the clustering transition in a compartementalized granular gas
Mikkelsen, René; van der Weele, Ko; van der Meer, Devaraj; van Hecke, Martin; Lohse, Detlef
2005-01-01
Statistical fluctuations are observed to profoundly influence the clustering behavior of granular material in a vibrated system consisting of two connected compartments. When the number of particles N is sufficiently large sN<300 is sufficientd, the clustering follows the lines of a standard
Andrew P. Kinziger; Rodney J. Nakamoto; Bret C. Harvey
2014-01-01
Given the general pattern of invasions with severe ecological consequences commonly resulting from multiple introductions of large numbers of individuals on the intercontinental scale, we explored an example of a highly successful, ecologically significant invader introduced over a short distance, possibly via minimal propagule pressure. The Sacramento pikeminnow (
Directory of Open Access Journals (Sweden)
Ilse Storch
2002-06-01
Full Text Available This paper explores the effects of spatial resolution on the performance and applicability of habitat models in wildlife management and conservation. A Habitat Suitability Index (HSI model for the Capercaillie (Tetrao urogallus in the Bavarian Alps, Germany, is presented. The model was exclusively built on non-spatial, small-scale variables of forest structure and without any consideration of landscape patterns. The main goal was to assess whether a HSI model developed from small-scale habitat preferences can explain differences in population abundance at larger scales. To validate the model, habitat variables and indirect sign of Capercaillie use (such as feathers or feces were mapped in six study areas based on a total of 2901 20 m radius (for habitat variables and 5 m radius sample plots (for Capercaillie sign. First, the model's representation of Capercaillie habitat preferences was assessed. Habitat selection, as expressed by Ivlev's electivity index, was closely related to HSI scores, increased from poor to excellent habitat suitability, and was consistent across all study areas. Then, habitat use was related to HSI scores at different spatial scales. Capercaillie use was best predicted from HSI scores at the small scale. Lowering the spatial resolution of the model stepwise to 36-ha, 100-ha, 400-ha, and 2000-ha areas and relating Capercaillie use to aggregated HSI scores resulted in a deterioration of fit at larger scales. Most importantly, there were pronounced differences in Capercaillie abundance at the scale of study areas, which could not be explained by the HSI model. The results illustrate that even if a habitat model correctly reflects a species' smaller scale habitat preferences, its potential to predict population abundance at larger scales may remain limited.
Determination of Curve Number for snowmelt-runoff floods in a small catchment
L. Hejduk; A. Hejduk; K. Banasik
2015-01-01
One of the widely used methods for predicting flood runoff depth from ungauged catchments is the curve number (CN) method, developed by Soil Conservation Service (SCS) of US Department of Agriculture. The CN parameter can be computed directly from recorded rainfall depths and direct runoff volumes in case of existing data. In presented investigations, the CN parameter has been computed for snowmelt-runoff events based on snowmelt and rainfall measurements. All required data ...
A novel micro-straw for cryopreservation of small number of human spermatozoon
Directory of Open Access Journals (Sweden)
Feng Liu
2017-01-01
Full Text Available Cryopreservation of few spermatozoa is still a major challenge for male fertility preservation. This study reports use a new micro-straw (LSL straw for freezing few spermatozoa for intracytoplasmic sperm injection (ICSI. Semen samples from 22 fertile donors were collected, and each semen sample was diluted and mixed with cryoprotectant in a ratio of 1:1, and then frozen using three different straws such as LSL straw (50-100 μl, traditional 0.25 ml and 0.5 ml straws. For freezing, all straws were fumigated with liquid nitrogen, with temperature directly reducing to −130-−140°C. Sperm concentration, progressive motility, morphology, acrosome integrity, and DNA fragmentation index were evaluated before and after freezing. After freezing-thawing, LSL straw group had significantly higher percentage of sperm motility than traditional 0.25 ml and 0.5 ml straw groups (38.5% vs 27.4% and 25.6%, P 0.05. As LSL straws were thinner and hold very small volume, the freezing rate of LSL straw was obviously faster than 0.25 ml straw and 0.5 ml straws. In conclusion, LSL micro-straws may be useful to store few motile spermatozoa with good recovery of motility for patients undergoing ICSI treatment.
International Nuclear Information System (INIS)
Kobayashi, Fujio; Yamaguchi, Shoichiro
1985-01-01
Fundamental studies have been made on the application of mathematical programming to the reconstruction of tomographic images from projections of a small number of views without requiring any circular symmetry nor periodicity. Linear programming and quadratic programming were applied to minimize the quadratic sum of the residue and to finally obtain optimized reconstruction images. The mathematical algorithms were verified by the method of computer simulation, and the relationship between the number of picture elements and the number of iterations necessary for convergence was also investigated. The methods of linear programming and quadratic programming require fairly simple mathematical procedures, and strict solutions can be obtained within a finite number of iterations. Their only draw back is the requirement of a large quantity of computer memory. But this problem will be desolved by the advent of large fast memory devices in the near future. (Aoki, K.)
Big Numbers about Small Children: Estimating the Economic Benefits of Addressing Undernutrition.
Alderman, Harold; Behrman, Jere R; Puett, Chloe
2017-02-01
Different approaches have been used to estimate the economic benefits of reducing undernutrition and to estimate the costs of investing in such programs on a global scale. While many of these studies are ultimately based on evidence from well-designed efficacy trials, all require a number of assumptions to project the impact of such trials to larger populations and to translate the value of the expected improvement in nutritional status into economic terms. This paper provides a short critique of some approaches to estimating the benefits of investments in child nutrition and then presents an alternative set of estimates based on different core data. These new estimates reinforce the basic conclusions of the existing literature: the economic value from reducing undernutrition in undernourished populations is likely to be substantial.
International Nuclear Information System (INIS)
Ijiri, K.; Potten, C.S.
1990-01-01
Survival curves were constructed from dose-incidence curves for apoptosis in the crypts of mouse small intestine, using the number of apoptotic cells after high doses (N M ) as maximum cell population size. The mean lethal doses (D 0 ) for the dose range 0-0.5 Gy were calculated for each time of day. A circadian rhythm in both D 0 and N M values was detected, indicating that both the number and sensitivity of radiation-induced apoptosis were changing throughout the day. (author)
Silva, Pedro; Vilar, Lu?s; Davids, Keith; Ara?jo, Duarte; Garganta, J?lio
2016-01-01
Small-sided and conditioned games (SSCGs) in sport have been modelled as complex adaptive systems. Research has shown that the relative space per player (RSP) formulated in SSCGs can impact on emergent tactical behaviours. In this study we adopted a systems orientation to analyse how different RSP values, obtained through manipulations of player numbers, influenced four measures of interpersonal coordination observed during performance in SSCGs. For this purpose we calculated positional data ...
Experimental Method for Plotting S-N Curve with a Small Number of Specimens
Directory of Open Access Journals (Sweden)
Strzelecki Przemysław
2016-12-01
Full Text Available The study presents two approaches to plotting an S-N curve based on the experimental results. The first approach is commonly used by researchers and presented in detail in many studies and standard documents. The model uses a linear regression whose parameters are estimated by using the least squares method. A staircase method is used for an unlimited fatigue life criterion. The second model combines the S-N curve defined as a straight line and the record of random occurrence of the fatigue limit. A maximum likelihood method is used to estimate the S-N curve parameters. Fatigue data for C45+C steel obtained in the torsional bending test were used to compare the estimated S-N curves. For pseudo-random numbers generated by using the Mersenne Twister algorithm, the estimated S-N curve for 10 experimental results plotted by using the second model, estimates the fatigue life in the scatter band of the factor 3. The result gives good approximation, especially regarding the time required to plot the S-N curve.
Baris, Engin
Distributed electric propulsion systems benefit from the inherent scale independence of electric propulsion. This property allows the designer to place multiple small electric motors along the wing of an aircraft instead of using a single or several internal combustion motors with gear boxes or other power train components. Aircraft operating at low Reynolds numbers are ideal candidates for benefiting from increased local flow velocities as provided by distributed propulsion systems. In this study, a distributed electric propulsion system made up of eight motor/propellers was integrated into the leading edge of a small fixed wing-body model to investigate the expected improvements on the aerodynamics available to small UAVs operating at low Reynolds numbers. Wind tunnel tests featuring a Design of Experiments (DOE) methodology were used for aerodynamic characterization. Experiments were performed in four modes: all-propellers-on, wing-tip-propellers-alone-on, wing-alone mode, and two-inboard-propellers-on-alone mode. In addition, the all-propeller-on, wing-alone, and a single-tractor configuration were analyzed using VSPAERO, a vortex lattice code, to make comparisons between these different configurations. Results show that the distributed propulsion system has higher normal force, endurance, and range features, despite a potential weight penalty.
Energy Technology Data Exchange (ETDEWEB)
Sato, Mai [Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902 (Japan); Kitaguchi, Tetsuya [Cell Signaling Group, Waseda Bioscience Research Institute in Singapore (WABOIS), Waseda University, 11 Biopolis Way, 05-01/02 Helios, Singapore 138667 (Singapore); Numano, Rika [The Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology, 1-1 Hibarigaoka, Tennpaku-cho, Toyohashi, Aichi 441-8580 (Japan); Ikematsu, Kazuya [Forensic Pathology and Science, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523 (Japan); Kakeyama, Masaki [Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033 (Japan); Murata, Masayuki; Sato, Ken [Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902 (Japan); Tsuboi, Takashi, E-mail: takatsuboi@bio.c.u-tokyo.ac.jp [Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902 (Japan)
2012-04-06
Highlights: Black-Right-Pointing-Pointer Regulation of exocytosis by Rho GTPase Cdc42. Black-Right-Pointing-Pointer Cdc42 increases the number of fusion events from newly recruited vesicles. Black-Right-Pointing-Pointer Cdc42 increases the number of exocytosis-competent dense-core vesicles. -- Abstract: Although the small GTPase Rho family Cdc42 has been shown to facilitate exocytosis through increasing the amount of hormones released, the precise mechanisms regulating the quantity of hormones released on exocytosis are not well understood. Here we show by live cell imaging analysis under TIRF microscope and immunocytochemical analysis under confocal microscope that Cdc42 modulated the number of fusion events and the number of dense-core vesicles produced in the cells. Overexpression of a wild-type or constitutively-active form of Cdc42 strongly facilitated high-KCl-induced exocytosis from the newly recruited plasma membrane vesicles in PC12 cells. By contrast, a dominant-negative form of Cdc42 inhibited exocytosis from both the newly recruited and previously docked plasma membrane vesicles. The number of intracellular dense-core vesicles was increased by the overexpression of both a wild-type and constitutively-active form of Cdc42. Consistently, activation of Cdc42 by overexpression of Tuba, a Golgi-associated guanine nucleotide exchange factor for Cdc42 increased the number of intracellular dense-core vesicles, whereas inhibition of Cdc42 by overexpression of the Cdc42/Rac interactive binding domain of neuronal Wiskott-Aldrich syndrome protein decreased the number of them. These findings suggest that Cdc42 facilitates exocytosis by modulating both the number of exocytosis-competent dense-core vesicles and the production of dense-core vesicles in PC12 cells.
International Nuclear Information System (INIS)
Sato, Mai; Kitaguchi, Tetsuya; Numano, Rika; Ikematsu, Kazuya; Kakeyama, Masaki; Murata, Masayuki; Sato, Ken; Tsuboi, Takashi
2012-01-01
Highlights: ► Regulation of exocytosis by Rho GTPase Cdc42. ► Cdc42 increases the number of fusion events from newly recruited vesicles. ► Cdc42 increases the number of exocytosis-competent dense-core vesicles. -- Abstract: Although the small GTPase Rho family Cdc42 has been shown to facilitate exocytosis through increasing the amount of hormones released, the precise mechanisms regulating the quantity of hormones released on exocytosis are not well understood. Here we show by live cell imaging analysis under TIRF microscope and immunocytochemical analysis under confocal microscope that Cdc42 modulated the number of fusion events and the number of dense-core vesicles produced in the cells. Overexpression of a wild-type or constitutively-active form of Cdc42 strongly facilitated high-KCl-induced exocytosis from the newly recruited plasma membrane vesicles in PC12 cells. By contrast, a dominant-negative form of Cdc42 inhibited exocytosis from both the newly recruited and previously docked plasma membrane vesicles. The number of intracellular dense-core vesicles was increased by the overexpression of both a wild-type and constitutively-active form of Cdc42. Consistently, activation of Cdc42 by overexpression of Tuba, a Golgi-associated guanine nucleotide exchange factor for Cdc42 increased the number of intracellular dense-core vesicles, whereas inhibition of Cdc42 by overexpression of the Cdc42/Rac interactive binding domain of neuronal Wiskott–Aldrich syndrome protein decreased the number of them. These findings suggest that Cdc42 facilitates exocytosis by modulating both the number of exocytosis-competent dense-core vesicles and the production of dense-core vesicles in PC12 cells.
Luo, Xian; Li, Liang
2017-11-07
In cellular metabolomics, it is desirable to carry out metabolomic profiling using a small number of cells in order to save time and cost. In some applications (e.g., working with circulating tumor cells in blood), only a limited number of cells are available for analysis. In this report, we describe a method based on high-performance chemical isotope labeling (CIL) nanoflow liquid chromatography mass spectrometry (nanoLC-MS) for high-coverage metabolomic analysis of small numbers of cells (i.e., ≤10000 cells). As an example, 12 C-/ 13 C-dansyl labeling of the metabolites in lysates of 100, 1000, and 10000 MCF-7 breast cancer cells was carried out using a new labeling protocol tailored to handle small amounts of metabolites. Chemical-vapor-assisted ionization in a captivespray interface was optimized for improving metabolite ionization and increasing robustness of nanoLC-MS. Compared to microflow LC-MS, the nanoflow system provided much improved metabolite detectability with a significantly reduced sample amount required for analysis. Experimental duplicate analyses of biological triplicates resulted in the detection of 1620 ± 148, 2091 ± 89 and 2402 ± 80 (n = 6) peak pairs or metabolites in the amine/phenol submetabolome from the 12 C-/ 13 C-dansyl labeled lysates of 100, 1000, and 10000 cells, respectively. About 63-69% of these peak pairs could be either identified using dansyl labeled standard library or mass-matched to chemical structures in human metabolome databases. We envisage the routine applications of this method for high-coverage quantitative cellular metabolomics using a starting material of 10000 cells. Even for analyzing 100 or 1000 cells, although the metabolomic coverage is reduced from the maximal coverage, this method can still detect thousands of metabolites, allowing the analysis of a large fraction of the metabolome and focused analysis of the detectable metabolites.
Directory of Open Access Journals (Sweden)
Barbara Miceli
2018-01-01
Full Text Available Il saggio è l’analisi di due romanzi di Margaret Atwood ambientati in due città/società con un funzionamento apparentemente perfetto che le rende sicure, pulite, prive di crimine e disciplinate. I romanzi, The Handmaid’s Tale (1985 e The Heart Goes Last (2015, sono ambientati nelle città fittizie di Gilead e Consilience, situate negli Stati Uniti. Tali società condividono alcune caratteristiche, e applicano i principi della prigione studiati da Foucault nel saggio Discipline and Punish, in particolare per ciò che riguarda il controllo sul corpo delle persone per renderle “docili” e utili, l’isolamento dal mondo esterno e le punizioni (torture ed esecuzioni che rendono le persone soggiogate al potere. L’apparente perfezione di Gilead e di Consilience nasconde elementi distopici che, secondo l’autrice, potrebbero rappresentare il futuro delle nostre città, e una misura estrema che suscita dibattiti e riflessioni su quanto una simile gestione della società possa essere peggiore di quella in cui viviamo.
Directory of Open Access Journals (Sweden)
Verena Jabs
Full Text Available Non-small cell lung cancer (NSCLC represents a genomically unstable cancer type with extensive copy number aberrations. The relationship of gene copy number alterations and subsequent mRNA levels has only fragmentarily been described. The aim of this study was to conduct a genome-wide analysis of gene copy number gains and corresponding gene expression levels in a clinically well annotated NSCLC patient cohort (n = 190 and their association with survival. While more than half of all analyzed gene copy number-gene expression pairs showed statistically significant correlations (10,296 of 18,756 genes, high correlations, with a correlation coefficient >0.7, were obtained only in a subset of 301 genes (1.6%, including KRAS, EGFR and MDM2. Higher correlation coefficients were associated with higher copy number and expression levels. Strong correlations were frequently based on few tumors with high copy number gains and correspondingly increased mRNA expression. Among the highly correlating genes, GO groups associated with posttranslational protein modifications were particularly frequent, including ubiquitination and neddylation. In a meta-analysis including 1,779 patients we found that survival associated genes were overrepresented among highly correlating genes (61 of the 301 highly correlating genes, FDR adjusted p<0.05. Among them are the chaperone CCT2, the core complex protein NUP107 and the ubiquitination and neddylation associated protein CAND1. In conclusion, in a comprehensive analysis we described a distinct set of highly correlating genes. These genes were found to be overrepresented among survival-associated genes based on gene expression in a large collection of publicly available datasets.
Bozorgzadeh, Nezam; Yanagimura, Yoko; Harrison, John P.
2017-12-01
The Hoek-Brown empirical strength criterion for intact rock is widely used as the basis for estimating the strength of rock masses. Estimations of the intact rock H-B parameters, namely the empirical constant m and the uniaxial compressive strength σc, are commonly obtained by fitting the criterion to triaxial strength data sets of small sample size. This paper investigates how such small sample sizes affect the uncertainty associated with the H-B parameter estimations. We use Monte Carlo (MC) simulation to generate data sets of different sizes and different combinations of H-B parameters, and then investigate the uncertainty in H-B parameters estimated from these limited data sets. We show that the uncertainties depend not only on the level of variability but also on the particular combination of parameters being investigated. As particular combinations of H-B parameters can informally be considered to represent specific rock types, we discuss that as the minimum number of required samples depends on rock type it should correspond to some acceptable level of uncertainty in the estimations. Also, a comparison of the results from our analysis with actual rock strength data shows that the probability of obtaining reliable strength parameter estimations using small samples may be very low. We further discuss the impact of this on ongoing implementation of reliability-based design protocols and conclude with suggestions for improvements in this respect.
Effect of the number of ball contacts within bouts of 4 vs. 4 small-sided soccer games.
Dellal, Alexandre; Lago-Penas, Carlos; Wong, Del P; Chamari, Karim
2011-09-01
The aim of this study was to examine the influence of the number of ball touches authorized per possession on the physical demands, technical performances and physiological responses throughout the bouts within 4 vs. 4 soccer small-sided games (SSGs). Twenty international soccer players (27.4 ± 1.5 y, 180.6 ± 2.3 cm, 79.2 ± 4.2 kg, body fat 12.7 ± 1.2%) performed three different 4 vs. 4 SSGs (4 × 4 min) in which the number of ball touches authorized per possession was manipulated (1 touch = 1T; 2 touches = 2T; Free Play = FP). The SSGs were divided in 4 bouts (B1, B2, B3 and B4) separated by 3 min of passive recovery. The physical performances, technical activities, heart rate responses, blood lactate and RPE were analyzed. The FP rule presented greater number of duels, induced the lowest decreases of the sprint and high-intensity performances, and affected less the technical actions (successful passes and number of ball losses) from B1 to B4 as compared with 1T and 2T forms. Moreover, the SSG played in 1T form led to reach higher solicitation of the high-intensity actions while players presented more difficulty to perform a correct technical action. The modification of the number of ball touches authorized per possession affects the soccer player activity from the first to the last bout of SSG, indicating that the determination of this rule has to be precisely planned by the coach according to the objectives of the training.
Silva, Pedro; Vilar, Luís; Davids, Keith; Araújo, Duarte; Garganta, Júlio
2016-01-01
Small-sided and conditioned games (SSCGs) in sport have been modelled as complex adaptive systems. Research has shown that the relative space per player (RSP) formulated in SSCGs can impact on emergent tactical behaviours. In this study we adopted a systems orientation to analyse how different RSP values, obtained through manipulations of player numbers, influenced four measures of interpersonal coordination observed during performance in SSCGs. For this purpose we calculated positional data (GPS 15 Hz) from ten U-15 football players performing in three SSCGs varying in player numbers (3v3, 4v4 and 5v5). Key measures of SSCG system behaviours included values of (1) players' dispersion, (2) teams' separateness, (3) coupling strength and time delays between participants' emerging movements, respectively. Results showed that values of participants' dispersion increased, but the teams' separateness remained identical across treatments. Coupling strength and time delay also showed consistent values across SSCGs. These results exemplified how complex adaptive systems, like football teams, can harness inherent degeneracy to maintain similar team spatial-temporal relations with opponents through changes in inter-individual coordination modes (i.e., players' dispersion). The results imply that different team behaviours might emerge at different ratios of field dimension/player numbers. Therefore, sport pedagogists should carefully evaluate the effects of changing RSP in SSCGs as a way of promoting increased or decreased pressure on players.
2010-01-22
... System (NPDES) general permit to placer mining operations in Idaho for small suction dredges (intake... ENVIRONMENTAL PROTECTION AGENCY [FRL-9104-3] Proposed Issuance of a General NPDES Permit for Small... significant economic impact on a substantial number of small entities.'' EPA has concluded that NPDES general...
Forman, Ruth; Bramhall, Michael; Logunova, Larisa; Svensson-Frej, Marcus; Cruickshank, Sheena M; Else, Kathryn J
2016-05-31
Eosinophils are innate immune cells present in the intestine during steady state conditions. An intestinal eosinophilia is a hallmark of many infections and an accumulation of eosinophils is also observed in the intestine during inflammatory disorders. Classically the function of eosinophils has been associated with tissue destruction, due to the release of cytotoxic granule contents. However, recent evidence has demonstrated that the eosinophil plays a more diverse role in the immune system than previously acknowledged, including shaping adaptive immune responses and providing plasma cell survival factors during the steady state. Importantly, it is known that there are regional differences in the underlying immunology of the small and large intestine, but whether there are differences in context of the intestinal eosinophil in the steady state or inflammation is not known. Our data demonstrates that there are fewer IgA(+) plasma cells in the small intestine of eosinophil-deficient ΔdblGATA-1 mice compared to eosinophil-sufficient wild-type mice, with the difference becoming significant post-infection with Toxoplasma gondii. Remarkably, and in complete contrast, the absence of eosinophils in the inflamed large intestine does not impact on IgA(+) cell numbers during steady state, and is associated with a significant increase in IgA(+) cells post-infection with Trichuris muris compared to wild-type mice. Thus, the intestinal eosinophil appears to be less important in sustaining the IgA(+) cell pool in the large intestine compared to the small intestine, and in fact, our data suggests eosinophils play an inhibitory role. The dichotomy in the influence of the eosinophil over small and large intestinal IgA(+) cells did not depend on differences in plasma cell growth factors, recruitment potential or proliferation within the different regions of the gastrointestinal tract (GIT). We demonstrate for the first time that there are regional differences in the requirement of
Chu, Julio; Luckring, James M.
1996-01-01
An experimental wind tunnel test of a 65 deg. delta wing model with interchangeable leading edges was conducted in the Langley National Transonic Facility (NTF). The objective was to investigate the effects of Reynolds and Mach numbers on slender-wing leading-edge vortex flows with four values of wing leading-edge bluntness. Experimentally obtained pressure data are presented without analysis in tabulated and graphical formats across a Reynolds number range of 6 x 10(exp 6) to 84 x 10(exp 6) at a Mach number of 0.85 and across a Mach number range of 0.4 to 0.9 at Reynolds numbers of 6 x 10(exp 6) and 60 x 10(exp 6). Normal-force and pitching-moment coefficient plots for these Reynolds number and Mach number ranges are also presented.
Felderhof, B. U.
2017-09-01
Translational and rotational swimming at small Reynolds numbers of a planar assembly of identical spheres immersed in an incompressible viscous fluid is studied on the basis of a set of equations of motion for the individual spheres. The motion of the spheres is caused by actuating forces and forces derived from a direct interaction potential, as well as hydrodynamic forces exerted by the fluid as frictional and added mass hydrodynamic interactions. The translational and rotational swimming velocities of the assembly are deduced from momentum and angular momentum balance equations. The mean power required during a period is calculated from an instantaneous power equation. Expressions are derived for the mean swimming velocities and the mean power, valid to second order in the amplitude of displacements from the relative equilibrium positions. Hence these quantities can be evaluated for prescribed periodic displacements. Explicit calculations are performed for three spheres interacting such that they form an equilateral triangle in the rest frame of the configuration.
DEFF Research Database (Denmark)
Sørensen, Karina; Andersen, Paal; Larsen, Lars
2008-01-01
The multiplex ligation-dependent probe amplification (MLPA) technique is a sensitive technique for relative quantification of up to 50 different nucleic acid sequences in a single reaction, and the technique is routinely used for copy number analysis in various syndromes and diseases. The aim...... of the study was to exploit the potential of MLPA when the DNA material is limited. The DNA concentration required in standard MLPA analysis is not attainable from dried blood spot samples (DBSS) often used in neonatal screening programs. A novel design of MLPA probes has been developed to permit for MLPA...... analysis on small amounts of DNA. Six patients with congenital adrenal hyperplasia (CAH) were used in this study. DNA was extracted from both whole blood and DBSS and subjected to MLPA analysis using normal and modified probes. Results were analyzed using GeneMarker and manual Excel analysis. A total...
Huang, Hening
2018-01-01
This paper is the second (Part II) in a series of two papers (Part I and Part II). Part I has quantitatively discussed the fundamental limitations of the t-interval method for uncertainty estimation with a small number of measurements. This paper (Part II) reveals that the t-interval is an ‘exact’ answer to a wrong question; it is actually misused in uncertainty estimation. This paper proposes a redefinition of uncertainty, based on the classical theory of errors and the theory of point estimation, and a modification of the conventional approach to estimating measurement uncertainty. It also presents an asymptotic procedure for estimating the z-interval. The proposed modification is to replace the t-based uncertainty with an uncertainty estimator (mean- or median-unbiased). The uncertainty estimator method is an approximate answer to the right question to uncertainty estimation. The modified approach provides realistic estimates of uncertainty, regardless of whether the population standard deviation is known or unknown, or if the sample size is small or large. As an application example of the modified approach, this paper presents a resolution to the Du-Yang paradox (i.e. Paradox 2), one of the three paradoxes caused by the misuse of the t-interval in uncertainty estimation.
Directory of Open Access Journals (Sweden)
Zacharko-Siembida Anna
2014-06-01
Full Text Available The quantities and distribution patterns of serotonin-immunoreactive (serotonin-IR enterochromaffin cells (EC were studied immunohistochemically in the small intestine of suckling piglets stimulated with red kidney bean lectin, and in nonstimulated, control animals. The co-expression patterns of serotonin with somatostatin (SOM or corticotropin releasing-factor (CRF were also studied. After the lectin treatment, the increased numbers of EC were noted in the duodenum of experimental animals. Lectin stimulation did not change the proportions of EC in the jejunum and ileum. In the duodenal epithelium of the lectin-stimulated piglets, the vast majority of serotonin-IR EC were distributed at the basis of crypts. After the lectin administration, the proportions of serotonin-IR/SOM-IR EC were statistically similar in all sections of the small intestine. No upregulation of CRF was found in duodenal, jejunal, and ileal EC of lectin-treated animals. The findings demonstrated that red kidney bean lectin increased the serotonin reservoir in the duodenum, and thus may be an effective stimulant of the gut maturation in suckling mammals.
Romano, N.; Petroselli, A.; Grimaldi, S.
2012-04-01
With the aim of combining the practical advantages of the Soil Conservation Service - Curve Number (SCS-CN) method and Green-Ampt (GA) infiltration model, we have developed a mixed procedure, which is referred to as CN4GA (Curve Number for Green-Ampt). The basic concept is that, for a given storm, the computed SCS-CN total net rainfall amount is used to calibrate the soil hydraulic conductivity parameter of the Green-Ampt model so as to distribute in time the information provided by the SCS-CN method. In a previous contribution, the proposed mixed procedure was evaluated on 100 observed events showing encouraging results. In this study, a sensitivity analysis is carried out to further explore the feasibility of applying the CN4GA tool in small ungauged catchments. The proposed mixed procedure constrains the GA model with boundary and initial conditions so that the GA soil hydraulic parameters are expected to be insensitive toward the net hyetograph peak. To verify and evaluate this behaviour, synthetic design hyetograph and synthetic rainfall time series are selected and used in a Monte Carlo analysis. The results are encouraging and confirm that the parameter variability makes the proposed method an appropriate tool for hydrologic predictions in ungauged catchments. Keywords: SCS-CN method, Green-Ampt method, rainfall excess, ungauged basins, design hydrograph, rainfall-runoff modelling.
Krahulcová, Anna; Trávnícek, Pavel; Krahulec, František; Rejmánek, Marcel
2017-04-01
Aesculus L. (horse chestnut, buckeye) is a genus of 12-19 extant woody species native to the temperate Northern Hemisphere. This genus is known for unusually large seeds among angiosperms. While chromosome counts are available for many Aesculus species, only one has had its genome size measured. The aim of this study is to provide more genome size data and analyse the relationship between genome size and seed mass in this genus. Chromosome numbers in root tip cuttings were confirmed for four species and reported for the first time for three additional species. Flow cytometric measurements of 2C nuclear DNA values were conducted on eight species, and mean seed mass values were estimated for the same taxa. The same chromosome number, 2 n = 40, was determined in all investigated taxa. Original measurements of 2C values for seven Aesculus species (eight taxa), added to just one reliable datum for A. hippocastanum , confirmed the notion that the genome size in this genus with relatively large seeds is surprisingly low, ranging from 0·955 pg 2C -1 in A. parviflora to 1·275 pg 2C -1 in A. glabra var. glabra. The chromosome number of 2 n = 40 seems to be conclusively the universal 2 n number for non-hybrid species in this genus. Aesculus genome sizes are relatively small, not only within its own family, Sapindaceae, but also within woody angiosperms. The genome sizes seem to be distinct and non-overlapping among the four major Aesculus clades. These results provide an extra support for the most recent reconstruction of Aesculus phylogeny. The correlation between the 2C values and seed masses in examined Aesculus species is slightly negative and not significant. However, when the four major clades are treated separately, there is consistent positive association between larger genome size and larger seed mass within individual lineages. © The Author 2017. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For
International Nuclear Information System (INIS)
Khisamutdinov, A I; Velker, N N
2014-01-01
The talk examines a system of pairwise interaction particles, which models a rarefied gas in accordance with the nonlinear Boltzmann equation, the master equations of Markov evolution of this system and corresponding numerical Monte Carlo methods. Selection of some optimal method for simulation of rarefied gas dynamics depends on the spatial size of the gas flow domain. For problems with the Knudsen number K n of order unity 'imitation', or 'continuous time', Monte Carlo methods ([2]) are quite adequate and competitive. However if K n ≤ 0.1 (the large sizes), excessive punctuality, namely, the need to see all the pairs of particles in the latter, leads to a significant increase in computational cost(complexity). We are interested in to construct the optimal methods for Boltzmann equation problems with large enough spatial sizes of the flow. Speaking of the optimal, we mean that we are talking about algorithms for parallel computation to be implemented on high-performance multi-processor computers. The characteristic property of large systems is the weak dependence of sub-parts of each other at a sufficiently small time intervals. This property is taken into account in the approximate methods using various splittings of operator of corresponding master equations. In the paper, we develop the approximate method based on the splitting of the operator of master equations system 'over groups of particles' ([7]). The essence of the method is that the system of particles is divided into spatial subparts which are modeled independently for small intervals of time, using the precise 'imitation' method. The type of splitting used is different from other well-known type 'over collisions and displacements', which is an attribute of the known Direct simulation Monte Carlo methods. The second attribute of the last ones is the grid of the 'interaction cells', which is completely absent in the imitation methods. The
Zhou, Bing-Rui; Feng, Hanqiao; Ghirlando, Rodolfo; Li, Shipeng; Schwieters, Charles D; Bai, Yawen
2016-10-09
Linker histones bind to the nucleosome and regulate the structure and function of chromatin. We have previously shown that the globular domains of chicken H5 and Drosophila H1 linker histones bind to the nucleosome with on- or off-dyad modes, respectively. To explore the determinant for the distinct binding modes, we investigated the binding of a mutant globular domain of H5 to the nucleosome. This mutant, termed GH5_pMut, includes substitutions of five globular domain residues of H5 with the corresponding residues in the globular domain of Drosophila H1. The residues at these five positions play important roles in nucleosome binding by either H5 or Drosophila H1. NMR and spin-labeling experiments showed that GH5_pMut bound to the nucleosome off the dyad. We further found that the nucleosome array condensed by either the GH5_pMut or the globular domain of Drosophila H1 displayed a similar sedimentation coefficient, whereas the same nucleosome array condensed by the wild-type globular domain of H5 showed a much larger sedimentation coefficient. Moreover, NMR and spin-labeling results from the study of the nucleosome in complex with the full-length human linker histone H1.0, whose globular domain shares high sequence conservation with the corresponding globular domain of H5, are consistent with an on-dyad binding mode. Taken together, our results suggest that a small number of residues in the globular domain of a linker histone can control its binding location on the nucleosome and higher-order chromatin structure. Copyright © 2016. Published by Elsevier Ltd.
Feng, Dai; Svetnik, Vladimir; Coimbra, Alexandre; Baumgartner, Richard
2014-01-01
The intraclass correlation coefficient (ICC) with fixed raters or, equivalently, the concordance correlation coefficient (CCC) for continuous outcomes is a widely accepted aggregate index of agreement in settings with small number of raters. Quantifying the precision of the CCC by constructing its confidence interval (CI) is important in early drug development applications, in particular in qualification of biomarker platforms. In recent years, there have been several new methods proposed for construction of CIs for the CCC, but their comprehensive comparison has not been attempted. The methods consisted of the delta method and jackknifing with and without Fisher's Z-transformation, respectively, and Bayesian methods with vague priors. In this study, we carried out a simulation study, with data simulated from multivariate normal as well as heavier tailed distribution (t-distribution with 5 degrees of freedom), to compare the state-of-the-art methods for assigning CI to the CCC. When the data are normally distributed, the jackknifing with Fisher's Z-transformation (JZ) tended to provide superior coverage and the difference between it and the closest competitor, the Bayesian method with the Jeffreys prior was in general minimal. For the nonnormal data, the jackknife methods, especially the JZ method, provided the coverage probabilities closest to the nominal in contrast to the others which yielded overly liberal coverage. Approaches based upon the delta method and Bayesian method with conjugate prior generally provided slightly narrower intervals and larger lower bounds than others, though this was offset by their poor coverage. Finally, we illustrated the utility of the CIs for the CCC in an example of a wake after sleep onset (WASO) biomarker, which is frequently used in clinical sleep studies of drugs for treatment of insomnia.
Bulf, Hermann; de Hevia, Maria Dolores; Macchi Cassia, Viola
2016-01-01
Numbers are represented as ordered magnitudes along a spatially oriented number line. While culture and formal education modulate the direction of this number-space mapping, it is a matter of debate whether its emergence is entirely driven by cultural experience. By registering 8-9-month-old infants' eye movements, this study shows that numerical…
Directory of Open Access Journals (Sweden)
Annelies CEULEMANS
2014-03-01
Full Text Available Many studies tested the association between numerical magnitude processing and mathematical achievement with conflicting findings reported for individuals with mathematical learning disorders. Some of the inconsistencies might be explained by the number of non-symbolic stimuli or dot collections used in studies. It has been hypothesized that there is an object-file system for ‘small’ and an analogue magnitude system for ‘large’ numbers. This two-system account has been supported by the set size limit of the object-file system (three items. A boundary was defined, accordingly, categorizing numbers below four as ‘small’ and from four and above as ‘large’. However, data on ‘small’ number processing and on the ‘boundary’ between small and large numbers are missing. In this contribution we provide data from infants discriminating between the number sets 4 vs. 8 and 1 vs. 4, both containing the number four combined with a small and a large number respectively. Participants were 25 and 26 full term 9-month-olds for 4 vs. 8 and 1 vs. 4 respectively. The stimuli (dots were controlled for continuous variables. Eye-tracking was combined with the habituation paradigm. The results showed that the infants were successful in discriminating 1 from 4, but failed to discriminate 4 from 8 dots. This finding supports the assumption of the number four as a ‘small’ number and enlarges the object-file system’s limit. This study might help to explain inconsistencies in studies. Moreover, the information may be useful in answering parent’s questions about challenges that vulnerable children with number processing problems, such as children with mathematical learning disorders, might encounter. In addition, the study might give some information on the stimuli that can be used to effectively foster children’s magnitude processing skills.
Rhodes, Jonathan R.; Lunney, Daniel; Callaghan, John; McAlpine, Clive A.
2014-01-01
Roads and vehicular traffic are among the most pervasive of threats to biodiversity because they fragmenting habitat, increasing mortality and opening up new areas for the exploitation of natural resources. However, the number of vehicles on roads is increasing rapidly and this is likely to continue into the future, putting increased pressure on wildlife populations. Consequently, a major challenge is the planning of road networks to accommodate increased numbers of vehicles, while minimising impacts on wildlife. Nonetheless, we currently have few principles for guiding decisions on road network planning to reduce impacts on wildlife in real landscapes. We addressed this issue by developing an approach for quantifying the impact on wildlife mortality of two alternative mechanisms for accommodating growth in vehicle numbers: (1) increasing the number of roads, and (2) increasing traffic volumes on existing roads. We applied this approach to a koala (Phascolarctos cinereus) population in eastern Australia and quantified the relative impact of each strategy on mortality. We show that, in most cases, accommodating growth in traffic through increases in volumes on existing roads has a lower impact than building new roads. An exception is where the existing road network has very low road density, but very high traffic volumes on each road. These findings have important implications for how we design road networks to reduce their impacts on biodiversity. PMID:24646891
Directory of Open Access Journals (Sweden)
Jonathan R Rhodes
Full Text Available Roads and vehicular traffic are among the most pervasive of threats to biodiversity because they fragmenting habitat, increasing mortality and opening up new areas for the exploitation of natural resources. However, the number of vehicles on roads is increasing rapidly and this is likely to continue into the future, putting increased pressure on wildlife populations. Consequently, a major challenge is the planning of road networks to accommodate increased numbers of vehicles, while minimising impacts on wildlife. Nonetheless, we currently have few principles for guiding decisions on road network planning to reduce impacts on wildlife in real landscapes. We addressed this issue by developing an approach for quantifying the impact on wildlife mortality of two alternative mechanisms for accommodating growth in vehicle numbers: (1 increasing the number of roads, and (2 increasing traffic volumes on existing roads. We applied this approach to a koala (Phascolarctos cinereus population in eastern Australia and quantified the relative impact of each strategy on mortality. We show that, in most cases, accommodating growth in traffic through increases in volumes on existing roads has a lower impact than building new roads. An exception is where the existing road network has very low road density, but very high traffic volumes on each road. These findings have important implications for how we design road networks to reduce their impacts on biodiversity.
Rhodes, Jonathan R; Lunney, Daniel; Callaghan, John; McAlpine, Clive A
2014-01-01
Roads and vehicular traffic are among the most pervasive of threats to biodiversity because they fragmenting habitat, increasing mortality and opening up new areas for the exploitation of natural resources. However, the number of vehicles on roads is increasing rapidly and this is likely to continue into the future, putting increased pressure on wildlife populations. Consequently, a major challenge is the planning of road networks to accommodate increased numbers of vehicles, while minimising impacts on wildlife. Nonetheless, we currently have few principles for guiding decisions on road network planning to reduce impacts on wildlife in real landscapes. We addressed this issue by developing an approach for quantifying the impact on wildlife mortality of two alternative mechanisms for accommodating growth in vehicle numbers: (1) increasing the number of roads, and (2) increasing traffic volumes on existing roads. We applied this approach to a koala (Phascolarctos cinereus) population in eastern Australia and quantified the relative impact of each strategy on mortality. We show that, in most cases, accommodating growth in traffic through increases in volumes on existing roads has a lower impact than building new roads. An exception is where the existing road network has very low road density, but very high traffic volumes on each road. These findings have important implications for how we design road networks to reduce their impacts on biodiversity.
Czech Academy of Sciences Publication Activity Database
Krahulcová, Anna; Trávníček, Pavel; Krahulec, František; Rejmánek, M.
2017-01-01
Roč. 119, č. 6 (2017), s. 957-964 ISSN 0305-7364 Institutional support: RVO:67985939 Keywords : Aesculus * chromosome number * genome size * phylogeny * seed mass Subject RIV: EF - Botanics OBOR OECD: Plant sciences, botany Impact factor: 4.041, year: 2016
International Nuclear Information System (INIS)
Pavelyev, D. G.; Vasilev, A. P.; Kozlov, V. A.; Koschurinov, Yu. I.; Obolenskaya, E. S.; Obolensky, S. V.; Ustinov, V. M.
2016-01-01
The electron transport in superlattices based on GaAs/AlAs heterostructures with a small number of periods (6 periods) is calculated by the Monte Carlo method. These superlattices are used in terahertz diodes for the frequency stabilization of quantum cascade lasers in the range up to 4.7 THz. The band structure of superlattices with different numbers of AlAs monolayers is considered and their current–voltage characteristics are calculated. The calculated current–voltage characteristics are compared with the experimental data. The possibility of the efficient application of these superlattices in the THz frequency range is established both theoretically and experimentally.
International Nuclear Information System (INIS)
Zhang, Hao; Wroblewski, Kristen; Pu, Yonglin
2012-01-01
Background: No study to test the feasibility and prognostic value of the number of primary tumors, the number of positive lymph nodes, and the total number of tumors in the whole body as tumor burden measurements on FDG PET/CT imaging has been reported. Purpose: To determine whether the number of tumors seen in 18F-FDG PET scans can be a prognostic factor in non-surgical patients with non-small cell lung cancer (NSCLC). Material and Methods: One hundred and forty patients with histologically proven NSCLC and baseline 18F-FDG PET scan before therapy were identified in this retrospective analysis. The total number of tumors (TTn) in the whole body, the number of primary tumors (Tn), positive lymph nodes (Nn), and distant metastases (Mn), along with the maximum standardized uptake values (SUVmax) of the tumors were measured. Inter-observer variability of the total number of tumors, counted by two radiologists, was assessed. Survival analyses were performed to determine the prognostic value of the number of tumors. Results: Concordance correlation coefficients for the TTn, Tn, Nn, and Mn were all greater than 0.85. TTn and Nn were strong prognostic factors of NSCLC patients' overall survival (OS). In univariate Cox regression models, gender, stage, TTn, Nn, and Mn were statistically significant factors (P = 0.016, 0.032, 4. Conclusion: Measuring the number of tumors on FDG PET imaging is easy to perform with minimal inter-observer variability. The total number of tumors and number of nodal metastases, as metabolic tumor burden measurements in 18F-FDG PET/CT, are prognostic markers independent of clinical stage, age, gender, and SUV measurement in non-surgical patients with NSCLC
Directory of Open Access Journals (Sweden)
Sučević Nikola
2017-01-01
Full Text Available In this paper the influence of a large number of small hydro power plants on the short-circuit currents is analysed, as well as the operation of the relay protection system within the real distribution network in Serbia. The necessary modification of the existing protection functions, as well as the implementation of the new proposed protection functions, are presented and discussed. Network modeling and analysis are performed using the program tool DIgSILENT PowerFactory.
Ulyanov, Sergey S.; Ulianova, Onega V.; Zaytsev, Sergey S.; Saltykov, Yury V.; Feodorova, Valentina A.
2018-04-01
The transformation mechanism for a nucleotide sequence of the Chlamydia trachomatis gene into a speckle pattern has been considered. The first and second-order statistics of gene-based speckles have been analyzed. It has been demonstrated that gene-based speckles do not obey Gaussian statistics and belong to the class of speckles with a small number of scatterers. It has been shown that gene polymorphism can be easily detected through analysis of the statistical characteristics of gene-based speckles.
Carranza, Emmanuel John M.; Laborte, Alice G.
2015-01-01
Machine learning methods that have been used in data-driven predictive modeling of mineral prospectivity (e.g., artificial neural networks) invariably require large number of training prospect/locations and are unable to handle missing values in certain evidential data. The Random Forests (RF) algorithm, which is a machine learning method, has recently been applied to data-driven predictive mapping of mineral prospectivity, and so it is instructive to further study its efficacy in this particular field. This case study, carried out using data from Abra (Philippines), examines (a) if RF modeling can be used for data-driven modeling of mineral prospectivity in areas with a few (i.e., individual layers of evidential data. Furthermore, RF modeling can handle missing values in evidential data through an RF-based imputation technique whereas in WofE modeling values are simply represented by zero weights. Therefore, the RF algorithm is potentially more useful than existing methods that are currently used for data-driven predictive mapping of mineral prospectivity. In particular, it is not a purely black-box method like artificial neural networks in the context of data-driven predictive modeling of mineral prospectivity. However, further testing of the method in other areas with a few mineral occurrences is needed to fully investigate its usefulness in data-driven predictive modeling of mineral prospectivity.
International Nuclear Information System (INIS)
Vazquez, Rafael; Ganan-Calvo, Alfonso M
2010-01-01
A systematic operational calculus framework that characterizes droplet/bubble size distributions resulting from turbulent breakup of an immiscible fluid into a carrier one is presented. The proposed formulation is derived from dynamical arguments; a finite-difference formulation of the integro-differential continuous coagulation and fragmentation equation is shown to exhibit the same structure as a discrete sequence of Mellin convolutions between the probability distribution of the evolving dispersed phase and a generic kernel. This kernel may have its physical correspondence with the probability distribution resulting from a single breakup event, e.g. a liquid ligament breakup in a ligament-mediated spray formation. The number of convolution steps in the sequence can be reduced to a single parameter. As an illustration, this procedure is applied to the exponential and the gamma distributions, obtaining as a result the Frechet distribution earlier used by Rosin and Rammler (1934 Kolloid-Zeitschrift 67 16-26), and by Nukiyama and Tanasawa (1939 Trans. Soc. Mech. Eng. Japan 5 62-7). Thus, the framework introduced in this work provides a physical foundation for the success of the Frechet distribution in accurately fitting experimentally measured droplet size distributions in sprays and emulsions.
Energy Technology Data Exchange (ETDEWEB)
Vazquez, Rafael; Ganan-Calvo, Alfonso M, E-mail: amgc@us.e [Departamento de IngenierIa Aeroespacial y Mecanica de Fluidos, Universidad de Sevilla, e-41092 Sevilla (Spain)
2010-05-07
A systematic operational calculus framework that characterizes droplet/bubble size distributions resulting from turbulent breakup of an immiscible fluid into a carrier one is presented. The proposed formulation is derived from dynamical arguments; a finite-difference formulation of the integro-differential continuous coagulation and fragmentation equation is shown to exhibit the same structure as a discrete sequence of Mellin convolutions between the probability distribution of the evolving dispersed phase and a generic kernel. This kernel may have its physical correspondence with the probability distribution resulting from a single breakup event, e.g. a liquid ligament breakup in a ligament-mediated spray formation. The number of convolution steps in the sequence can be reduced to a single parameter. As an illustration, this procedure is applied to the exponential and the gamma distributions, obtaining as a result the Frechet distribution earlier used by Rosin and Rammler (1934 Kolloid-Zeitschrift 67 16-26), and by Nukiyama and Tanasawa (1939 Trans. Soc. Mech. Eng. Japan 5 62-7). Thus, the framework introduced in this work provides a physical foundation for the success of the Frechet distribution in accurately fitting experimentally measured droplet size distributions in sprays and emulsions.
International Nuclear Information System (INIS)
Dai, Fuqiang; Liu, Lunxu; Che, Guowei; Yu, Nanbin; Pu, Qiang; Zhang, Shangfu; Ma, Junliang; Ma, Lin; You, Zongbing
2010-01-01
Tumor microenvironment is composed of tumor cells, fibroblasts, endothelial cells, and infiltrating immune cells. Tumor-associated immune cells may inhibit or promote tumor growth and progression. This study was conducted to determine whether the number and microlocalization of macrophages, mature dendritic cells and cytotoxic T cells in non-small cell lung cancer are associated with patient's survival time. Ninety-nine patients with non-small cell lung cancer (NSCLC) were included in this retrospective study. Paraffin-embedded NSCLC specimens and their clinicopathological data including up to 8-year follow-up information were used. Immunohistochemical staining for CD68 (marker for macrophages), CD83 (marker for mature dendritic cells), and CD8 (marker for cytotoxic T cells) was performed and evaluated in a blinded fashion. The numbers of immune cells in tumor islets and stroma, tumor islets, or tumor stroma were counted under a microscope. Correlation of the cell numbers and patient's survival time was analyzed using the Statistical Package for the Social Sciences (version 13.0). The numbers of macrophages, mature dendritic cells and cytotoxic T cells were significantly more in the tumor stroma than in the tumor islets. The number of macrophages in the tumor islets was positively associated with patient's survival time, whereas the number of macrophages in the tumor stroma was negatively associated with patient's survival time in both univariate and multivariate analyses. The number of mature dendritic cells in the tumor islets and stroma, tumor islets only, or tumor stroma only was positively associated with patient's survival time in a univariate analysis but not in a multivariate analysis. The number of cytotoxic T cells in the tumor islets and stroma was positively associated with patient's survival time in a univariate analysis but not in a multivariate analysis. The number of cytotoxic T cells in the tumor islets only or stroma
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Masahiro Sato
2017-08-01
Full Text Available In vivo inoculation of cells such as tumor cells and induced pluripotent stem (iPS/embryonic stem (ES cells into immunocompromised mice has been considered as a powerful technique to evaluate their potential to proliferate or differentiate into various cell types originating from three germ cell layers. Subcutaneous grafting and grafting under the kidney capsule have been widely used for this purpose, but there are some demerits such as the requirement of a large number of tumor cells for inoculation and frequent failure of tumorigenesis. Therefore, grafting into other sites has been explored, including intratesticular or intramuscular grafting as well as grafting into the cochleae, liver, or salivary glands. In this study, we found that intrapancreatic parenchymal injection of cells is useful for allowing a small number of cells (~15 × 103 cells or ~30 cell clumps μL−1·site−1 to proliferate and sometimes differentiate into various types of cells. It requires only surgical exposure of the pancreas over the dorsal skin and subsequent injection of cells towards the pancreatic parenchyma under dissecting microscope-based observation using a mouthpiece-controlled glass micropipette. We now name this technology “intrapancreatic parenchymal cell transplantation (IPPCT”, which will be useful, especially when only a small number of cells or colonies are available.
Finding Safety in Small Numbers.
McPartland, James; Jordan, Will; Legters, Nettie; Balfanz, Robert
1997-01-01
A large Baltimore high school has shown how personalizing relationships and focusing the curriculum can turn around an unsafe school and create a climate conducive to learning. The school adopted the Talent Development model, which created six smaller units or academies. Instead of suspending or transferring ill-behaved students, Patterson…
Rokicki, Slawa; Cohen, Jessica; Fink, Günther; Salomon, Joshua A; Landrum, Mary Beth
2018-01-01
Difference-in-differences (DID) estimation has become increasingly popular as an approach to evaluate the effect of a group-level policy on individual-level outcomes. Several statistical methodologies have been proposed to correct for the within-group correlation of model errors resulting from the clustering of data. Little is known about how well these corrections perform with the often small number of groups observed in health research using longitudinal data. First, we review the most commonly used modeling solutions in DID estimation for panel data, including generalized estimating equations (GEE), permutation tests, clustered standard errors (CSE), wild cluster bootstrapping, and aggregation. Second, we compare the empirical coverage rates and power of these methods using a Monte Carlo simulation study in scenarios in which we vary the degree of error correlation, the group size balance, and the proportion of treated groups. Third, we provide an empirical example using the Survey of Health, Ageing, and Retirement in Europe. When the number of groups is small, CSE are systematically biased downwards in scenarios when data are unbalanced or when there is a low proportion of treated groups. This can result in over-rejection of the null even when data are composed of up to 50 groups. Aggregation, permutation tests, bias-adjusted GEE, and wild cluster bootstrap produce coverage rates close to the nominal rate for almost all scenarios, though GEE may suffer from low power. In DID estimation with a small number of groups, analysis using aggregation, permutation tests, wild cluster bootstrap, or bias-adjusted GEE is recommended.
DEFF Research Database (Denmark)
Buslje, C.M.; Santos, J.; Delfino, J.M.
2009-01-01
Motivation: Mutual information (MI) theory is often applied to predict positional correlations in a multiple sequence alignment (MSA) to make possible the analysis of those positions structurally or functionally important in a given fold or protein family. Accurate identification of coevolving......-weighting techniques to reduce sequence redundancy and low-count corrections to account for small number of observations in limited size sequence families, can significantly improve the predictability of MI. The evaluation is made on large sets of both in silico-generated alignments as well as on biological sequence...
Grimaldi, S.; Petroselli, A.; Romano, N.
2012-04-01
The Soil Conservation Service - Curve Number (SCS-CN) method is a popular rainfall-runoff model that is widely used to estimate direct runoff from small and ungauged basins. The SCS-CN is a simple and valuable approach to estimate the total stream-flow volume generated by a storm rainfall, but it was developed to be used with daily rainfall data. To overcome this drawback, we propose to include the Green-Ampt (GA) infiltration model into a mixed procedure, which is referred to as CN4GA (Curve Number for Green-Ampt), aiming to distribute in time the information provided by the SCS-CN method so as to provide estimation of sub-daily incremental rainfall excess. For a given storm, the computed SCS-CN total net rainfall amount is used to calibrate the soil hydraulic conductivity parameter of the Green-Ampt model. The proposed procedure was evaluated by analyzing 100 rainfall-runoff events observed in four small catchments of varying size. CN4GA appears an encouraging tool for predicting the net rainfall peak and duration values and has shown, at least for the test cases considered in this study, a better agreement with observed hydrographs than that of the classic SCS-CN method.
Raghavan, Shreya; Ward, Maria R; Rowley, Katelyn R; Wold, Rachel M; Takayama, Shuichi; Buckanovich, Ronald J; Mehta, Geeta
2015-07-01
Ovarian cancer grows and metastasizes from multicellular spheroidal aggregates within the ascites fluid. Multicellular tumor spheroids are therefore physiologically significant 3D in vitro models for ovarian cancer research. Conventional hanging drop cultures require high starting cell numbers, and are tedious for long-term maintenance. In this study, we generate stable, uniform multicellular spheroids using very small number of ovarian cancer cells in a novel 384 well hanging drop array platform. We used novel tumor spheroid platform and two ovarian cancer cell lines (A2780 and OVCAR3) to demonstrate the stable incorporation of as few as 10 cells into a single spheroid. Spheroids had uniform geometry, with projected areas (42.60×10(3)μm-475.22×10(3)μm(2) for A2780 spheroids and 37.24×10(3)μm(2)-281.01×10(3)μm(2) for OVCAR3 spheroids) that varied as a function of the initial cell seeding density. Phalloidin and nuclear stains indicated cells formed tightly packed spheroids with demarcated boundaries and cell-cell interaction within spheroids. Cells within spheroids demonstrated over 85% viability. 3D tumor spheroids demonstrated greater resistance (70-80% viability) to cisplatin chemotherapy compared to 2D cultures (30-50% viability). Ovarian cancer spheroids can be generated from limited cell numbers in high throughput 384 well plates with high viability. Spheroids demonstrate therapeutic resistance relative to cells in traditional 2D culture. Stable incorporation of low cell numbers is advantageous when translating this research to rare patient-derived cells. This system can be used to understand ovarian cancer spheroid biology, as well as carry out preclinical drug sensitivity assays. Copyright © 2015 Elsevier Inc. All rights reserved.
Pailler, Emma; Oulhen, Marianne; Borget, Isabelle; Remon, Jordi; Ross, Kirsty; Auger, Nathalie; Billiot, Fanny; Ngo Camus, Maud; Commo, Frédéric; Lindsay, Colin R; Planchard, David; Soria, Jean-Charles; Besse, Benjamin; Farace, Françoise
2017-05-01
The duration and magnitude of clinical response are unpredictable in ALK -rearranged non-small cell lung cancer (NSCLC) patients treated with crizotinib, although all patients invariably develop resistance. Here, we evaluated whether circulating tumor cells (CTC) with aberrant ALK -FISH patterns [ ALK -rearrangement, ALK -copy number gain ( ALK -CNG)] monitored on crizotinib could predict progression-free survival (PFS) in a cohort of ALK -rearranged patients. Thirty-nine ALK -rearranged NSCLC patients treated with crizotinib as first ALK inhibitor were recruited prospectively. Blood samples were collected at baseline and at an early time-point (2 months) on crizotinib. Aberrant ALK -FISH patterns were examined in CTCs using immunofluorescence staining combined with filter-adapted FISH after filtration enrichment. CTCs were classified into distinct subsets according to the presence of ALK -rearrangement and/or ALK -CNG signals. No significant association between baseline numbers of ALK -rearranged or ALK -CNG CTCs and PFS was observed. However, we observed a significant association between the decrease in CTC number with ALK -CNG on crizotinib and a longer PFS (likelihood ratio test, P = 0.025). In multivariate analysis, the dynamic change of CTC with ALK -CNG was the strongest factor associated with PFS (HR, 4.485; 95% confidence interval, 1.543-13.030, P = 0.006). Although not dominant, ALK -CNG has been reported to be one of the mechanisms of acquired resistance to crizotinib in tumor biopsies. Our results suggest that the dynamic change in the numbers of CTCs with ALK -CNG may be a predictive biomarker for crizotinib efficacy in ALK -rearranged NSCLC patients. Serial molecular analysis of CTC shows promise for real-time patient monitoring and clinical outcome prediction in this population. Cancer Res; 77(9); 2222-30. ©2017 AACR . ©2017 American Association for Cancer Research.
Energy Technology Data Exchange (ETDEWEB)
Szymusiak, Magdalena; Kalkowski, Joseph; Luo, Hanying; Donovan, Alexander J.; Zhang, Pin; Liu, Chang; Shang, Weifeng; Irving, Thomas; Herrera-Alonso, Margarita; Liu, Ying (JHU); (IIT); (UIC)
2017-08-31
A large group of functional nanomaterials employed in biomedical applications, including targeted drug delivery, relies on amphiphilic polymers to encapsulate therapeutic payloads via self-assembly processes. Knowledge of the micelle structures will provide critical insights into design of polymeric drug delivery systems. Core–shell micelles composed of linear diblock copolymers poly(ethylene glycol)-b-poly(caprolactone) (PEG-b-PCL), poly(ethylene oxide)-b-poly(lactic acid) (PEG-b-PLA), as well as a heterografted brush consisting of a poly(glycidyl methacrylate) backbone with PEG and PLA branches (PGMA-g-PEG/PLA) were characterized by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS) measurements to gain structural information regarding the particle morphology, core–shell size, and aggregation number. The structural information at this quasi-equilibrium state can also be used as a reference when studying the kinetics of polymer micellization.
Energy Technology Data Exchange (ETDEWEB)
Szymusiak, Magdalena [Department; Kalkowski, Joseph [Department; Luo, Hanying [Department; Donovan, Alexander J. [Department; Zhang, Pin [Department; Liu, Chang [Department; Shang, Weifeng [Department; Irving, Thomas [Department; Herrera-Alonso, Margarita [Department; Liu, Ying [Department; Department
2017-08-16
A large group of functional nanomaterials employed in biomedical applications, including targeted drug delivery, relies on amphiphilic polymers to encapsulate therapeutic payloads via self-assembly processes. Knowledge of the micelle structures will provide critical insights into design of polymeric drug delivery systems. Core–shell micelles composed of linear diblock copolymers poly(ethylene glycol)-b-poly(caprolactone) (PEG-b-PCL), poly(ethylene oxide)-b-poly(lactic acid) (PEG-b-PLA), as well as a heterografted brush consisting of a poly(glycidyl methacrylate) backbone with PEG and PLA branches (PGMA-g-PEG/PLA) were characterized by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS) measurements to gain structural information regarding the particle morphology, core–shell size, and aggregation number. The structural information at this quasi-equilibrium state can also be used as a reference when studying the kinetics of polymer micellization.
Energy Technology Data Exchange (ETDEWEB)
Katoh, K [Ibaraki Pref. Univ. Health Sci., (Japan)
1997-12-31
A problem of estimating stochastic characteristics of a population from a small number of samples is solved as an inverse problem, from view point of information theory and with the Bayesian statistics. For both Poisson-process and Bernoulli-process, the most probable values of the characteristics of the mother population and their accuracies and degrees of confidence are successfully obtained. Mathematical expressions are given to the general case where a limit amount of information and/or knowledge with the stochastic characteristics are available and a special case where no a priori information nor knowledge are available. Mathematical properties of the solutions obtained, practical appreciation to the problem to radiation measurement are also discussed.
Atibalentja, N; Noel, G R; Ciancio, A
2004-03-01
For many years the taxonomy of the genus Pasteuria has been marred with confusion because the bacterium could not be cultured in vitro and, therefore, descriptions were based solely on morphological, developmental, and pathological characteristics. The current study sought to devise a simple method for PCR-amplification, cloning, and sequencing of Pasteuria 16S rDNA from small numbers of endospores, with no need for prior DNA purification. Results show that DNA extracts from plain glass bead-beating of crude suspensions containing 10,000 endospores at 0.2 x 10 endospores ml(-1) were sufficient for PCR-amplification of Pasteuria 16S rDNA, when used in conjunction with specific primers. These results imply that for P. penetrans and P. nishizawae only one parasitized female of Meloidogyne spp. and Heterodera glycines, respectively, should be sufficient, and as few as eight cadavers of Belonolaimus longicaudatus with an average number of 1,250 endospores of "Candidatus Pasteuria usgae" are needed for PCR-amplification of Pasteuria 16S rDNA. The method described in this paper should facilitate the sequencing of the 16S rDNA of the many Pasteuria isolates that have been reported on nematodes and, consequently, expedite the classification of those isolates through comparative sequence analysis.
Ma, Fei; Su, Jing; Yao, Bing
2018-05-01
The problem of determining and calculating the number of spanning trees of any finite graph (model) is a great challenge, and has been studied in various fields, such as discrete applied mathematics, theoretical computer science, physics, chemistry and the like. In this paper, firstly, thank to lots of real-life systems and artificial networks built by all kinds of functions and combinations among some simpler and smaller elements (components), we discuss some helpful network-operation, including link-operation and merge-operation, to design more realistic and complicated network models. Secondly, we present a method for computing the total number of spanning trees. As an accessible example, we apply this method to space of trees and cycles respectively, and our results suggest that it is indeed a better one for such models. In order to reflect more widely practical applications and potentially theoretical significance, we study the enumerating method in some existing scale-free network models. On the other hand, we set up a class of new models displaying scale-free feature, that is to say, following P(k) k-γ, where γ is the degree exponent. Based on detailed calculation, the degree exponent γ of our deterministic scale-free models satisfies γ > 3. In the rest of our discussions, we not only calculate analytically the solutions of average path length, which indicates our models have small-world property being prevailing in amounts of complex systems, but also derive the number of spanning trees by means of the recursive method described in this paper, which clarifies our method is convenient to research these models.
Directory of Open Access Journals (Sweden)
Jan Bělka
2016-12-01
Full Text Available Background: Effective training depends on knowledge of a sport's requirements. Small-sided games (SSG are a spontaneous form of specific training, where exercise intensity can be manipulated mainly by modifying external factors. In SSG the players develop technical and tactical skills in the similar situations, such as during a match and can also develop their physical skills. Objective: The purpose of this study was to examine the distance covered and physiological response of altering the number of youth male players during small-sided team handball games with modified rules. Methods: The subjects consisted of 12 male youth team handball players (age 16.6 ± 0.5 years playing the first league for youth male players in the Czech Republic. The study was conducted during six weeks (one training session per week. Only three SSG were played in each training session. The SSG were played, first with five players on each side (5 vs. 5, then four (4 vs. 4, then three (3 vs. 3. Each game was four minutes long, followed by three minutes of passive rest. Results: The players covered the greatest distance (520.6 ± 61.4 m in the SSG 3 vs. 3. There was a difference in the distance covered between players in the 3 vs. 3 SSG and the other SSG (4 vs. 4 and 5 vs. 5 (p = .041 and p = .043, respectively. In individual speed zones a difference occurred only in the first and third speed zone and always among the 3 vs. 3 and 5 vs. 5 SSG (p = .034 and p = .044, respectively. The highest average intensity (87.9 ± 4.8% HRmax was in 3 vs. 3 SSG. Loading of the players in 5 vs. 5 was lower compared to 4 vs. 4 (p = .035 and 3 vs. 3 (p < .001. There was a difference in zone load intensity (> 90% HRmax between 3 vs. 3 and 5 vs. 5 SSG (p = .041. Conclusions: These results indicate that changing the number of players during SSG with modified rules in youth team handball may be used to manipulate the physiological response
Kujawski, Joseph T.; Gliese, Ulrik B.; Cao, N. T.; Zeuch, M. A.; White, D.; Chornay, D. J; Lobell, J. V.; Avanov, L. A.; Barrie, A. C.; Mariano, A. J.;
2015-01-01
Each half of the Dual Electron Spectrometer (DES) of the Fast Plasma Investigation (FPI) on NASA's Magnetospheric MultiScale (MMS) mission utilizes a microchannel plate Chevron stack feeding 16 separate detection channels each with a dedicated anode and amplifier/discriminator chip. The desire to detect events on a single channel with a temporal spacing of 100 ns and a fixed dead-time drove our decision to use an amplifier/discriminator with a very fast (GHz class) front end. Since the inherent frequency response of each pulse in the output of the DES microchannel plate system also has frequency components above a GHz, this produced a number of design constraints not normally expected in electronic systems operating at peak speeds of 10 MHz. Additional constraints are imposed by the geometry of the instrument requiring all 16 channels along with each anode and amplifier/discriminator to be packaged in a relatively small space. We developed an electrical model for board level interactions between the detector channels to allow us to design a board topology which gave us the best detection sensitivity and lowest channel to channel crosstalk. The amplifier/discriminator output was designed to prevent the outputs from one channel from producing triggers on the inputs of other channels. A number of Radio Frequency design techniques were then applied to prevent signals from other subsystems (e.g. the high voltage power supply, command and data handling board, and Ultraviolet stimulation for the MCP) from generating false events. These techniques enabled us to operate the board at its highest sensitivity when operated in isolation and at very high sensitivity when placed into the overall system.
Effect of Number of Touches and Exercise Duration on the Kinematic Profile and Heart Rate Response During Small-Sided Games in Soccer
Directory of Open Access Journals (Sweden)
Casamichana David
2014-07-01
Full Text Available This study aimed to examine the effect of exercise duration and the number of touches allowed during possession on time-motion characteristics and the physiological responses of soccer players in 6 vs. 6 small-sided games (SSGs lasting 12 minutes. The analysis divided each game into two 6-min periods and we compared two formats: free play (SSGfp vs. a maximum of two touches per individual possession (SSG 2T. Participants were 12 semi-professional players (age: 22.7±4.3 years; body height: 177.5+4.9 cm; body mass: 74.9±6.3 kg and the following variables were measured by means of heart rate monitors and GPS devices: mean heart rate (HRmean, time spent in each exercise intensity zone, total distance covered, total distance covered in different speed zones, number of accelerations at different intensities, maximum speed reached, player load, and the work-to-rest ratio. The results showed that in SSGFP there was a decrease in the intensity of physical parameters during the second 6-min period (6-12 min, whereas this decrease was not observed when a maximum of two touches per individual possession was allowed. During the second period (6-12 min of SSG2T there was an increase in HRmean and in the time spent in high exercise intensity zones, but these differences were not observed in SSGFP. The value of these findings for soccer coaches is that they illustrate how different technical, tactical or conditioning objectives could be addressed by altering the length and format of the SSG used in training.
Waage, Astrid S.; Vardund, Traute; Lund, Vidar; Kapperud, Georg
1999-01-01
A rapid and sensitive assay was developed for detection of small numbers of Campylobacter jejuni and Campylobacter coli cells in environmental water, sewage, and food samples. Water and sewage samples were filtered, and the filters were enriched overnight in a nonselective medium. The enrichment cultures were prepared for PCR by a rapid and simple procedure consisting of centrifugation, proteinase K treatment, and boiling. A seminested PCR based on specific amplification of the intergenic sequence between the two Campylobacter flagellin genes, flaA and flaB, was performed, and the PCR products were visualized by agarose gel electrophoresis. The assay allowed us to detect 3 to 15 CFU of C. jejuni per 100 ml in water samples containing a background flora consisting of up to 8,700 heterotrophic organisms per ml and 10,000 CFU of coliform bacteria per 100 ml. Dilution of the enriched cultures 1:10 with sterile broth prior to the PCR was sometimes necessary to obtain positive results. The assay was also conducted with food samples analyzed with or without overnight enrichment. As few as ≤3 CFU per g of food could be detected with samples subjected to overnight enrichment, while variable results were obtained for samples analyzed without prior enrichment. This rapid and sensitive nested PCR assay provides a useful tool for specific detection of C. jejuni or C. coli in drinking water, as well as environmental water, sewage, and food samples containing high levels of background organisms. PMID:10103261
Bishop, Cecily V.; Xu, Fuhua; Xu, Jing; Ting, Alison Y.; Galbreath, Etienne; McGee, Whitney K.; Zelinski, Mary B.; Hennebold, Jon D.; Cameron, Judy L.; Stouffer, Richard L.
2015-01-01
Objective To examine the small antral follicle (SAF) cohort in ovaries of adult rhesus monkeys following consumption of a western-style diet (WSD), with or without chronically elevated androgen levels since before puberty. Design Cholesterol or testosterone (T; n=6/group) implants were placed subcutaneously in female rhesus macaques beginning at 1 yr of age (pre-pubertal), with addition of a WSD (high fat/fructose) at 5.5 yrs (menarche ~2.6 yrs). Ovaries were collected at 7 yrs of age. One ovary/female was embedded in paraffin for morphological and immunohistochemical analyses. The SAFs (Ovaries of adult monkeys consuming a standard macaque diet (low in fats and sugars) were obtained at similar stages of the menstrual cycle and used as controls for all analyses. Setting National primate research center Animals Adult, female rhesus monkeys (Macaca mulatta) Interventions None Main outcome measures Histological analyses, SAF counts and morphology, protein localization and abundance in SAFs, transcriptome in SAFs (mRNAs) Results Compared to controls, consumption of a WSD, with and without T treatment, increased the numbers of SAFs per ovary, due to the presence of more atretic follicles. Numbers of granulosa cells expressing cellular proliferation markers (pRb and pH3) was greater in healthy SAFs, while numbers of cells expressing the cell cycle inhibitor (p21) was higher in atretic SAFs. Intense CYP17A1 staining was observed in the theca cells of SAFs from WSD+/− T groups, compared to controls. Microarray analyses of the transcriptome in SAFs isolated from WSD and WSD+T treated females and controls consuming a standard diet, identified 1944 genes whose mRNA levels changed ≥2-fold among the three groups. Further analyses identified several gene pathways altered by WSD and/or WSD+T associated with steroid, carbohydrate and lipid metabolism, plus ovarian processes. Alterations in levels of several SAF mRNAs are similar to those observed in follicular cells from women
Koizumi, Nobuo; Izumiya, Hidemasa; Mu, Jung-Jung; Arent, Zbigniew; Okano, Shou; Nakajima, Chie; Suzuki, Yasuhiko; Mizutani Muto, Maki; Tanikawa, Tsutomu; Taylor, Kyle R; Komatsu, Noriyuki; Yoshimatsu, Kumiko; Thi Thu Ha, Hoang; Ohnishi, Makoto
2015-12-01
Leptospira spp. are the causative agents of a worldwide zoonosis, leptospirosis, maintained by various mammals. Each Leptospira serovar is frequently associated with a particular maintenance host, and recently, Leptospira genotype-host association has also been suggested to limit serovars to restricted areas. We investigated the molecular characteristics of L. interrogans and L. borgpetersenii which were isolated from small feral and wild animals in four East Asian states using multiple-locus variable-number tandem repeat analysis (MLVA). MLVA using 11 loci was performed on 110 L. interrogans serogroups from Japan (79 strains of 5 serogroups from 3 animal species), Philippines (21; 3; 2), Taiwan (7; 2; 3), and Vietnam (3; 1; 1). A MLVA method using 4 loci for L. borgpetersenii was established and performed on 52 isolates from Japan (26; 3; 7), Philippines (13; 1; 2), and Taiwan (13; 1; 3). In L. interrogans, serogroups Autumnalis and Hebdomadis appeared more genetically diverse than serogroups Bataviae, Grippotyphosa, Icterohaemorrhagiae, Pomona, or Pyrogenes. The former serogroup strains with the exception of one Hebdomadis strain were isolated from Apodemus speciosus while all the latter serogroup strains with the exception of Grippotyphosa were isolated from Rattus norvegicus. L. borgpetersenii was isolated from at least 11 animal species while L. interrogans was isolated from five species, which might suggest a wider host range for L. borgpetersenii. Broad host preference in a single genotype was also observed, which colonized not only different species of the same genera but also multiple animal genera. This study demonstrates that there may be variability in the range of genetic diversity among different Leptospira serogroups, which may be attributed to maintenance host animals and environmental factors. Copyright © 2015. Published by Elsevier B.V.
Boivin, Vincent; Deschamps-Francoeur, Gabrielle; Couture, Sonia; Nottingham, Ryan M; Bouchard-Bourelle, Philia; Lambowitz, Alan M; Scott, Michelle S; Abou-Elela, Sherif
2018-07-01
Comparing the abundance of one RNA molecule to another is crucial for understanding cellular functions but most sequencing techniques can target only specific subsets of RNA. In this study, we used a new fragmented ribodepleted TGIRT sequencing method that uses a thermostable group II intron reverse transcriptase (TGIRT) to generate a portrait of the human transcriptome depicting the quantitative relationship of all classes of nonribosomal RNA longer than 60 nt. Comparison between different sequencing methods indicated that FRT is more accurate in ranking both mRNA and noncoding RNA than viral reverse transcriptase-based sequencing methods, even those that specifically target these species. Measurements of RNA abundance in different cell lines using this method correlate with biochemical estimates, confirming tRNA as the most abundant nonribosomal RNA biotype. However, the single most abundant transcript is 7SL RNA, a component of the signal recognition particle. S tructured n on c oding RNAs (sncRNAs) associated with the same biological process are expressed at similar levels, with the exception of RNAs with multiple functions like U1 snRNA. In general, sncRNAs forming RNPs are hundreds to thousands of times more abundant than their mRNA counterparts. Surprisingly, only 50 sncRNA genes produce half of the non-rRNA transcripts detected in two different cell lines. Together the results indicate that the human transcriptome is dominated by a small number of highly expressed sncRNAs specializing in functions related to translation and splicing. © 2018 Boivin et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.
Kunstler, Breanne E; Cook, Jill L; Freene, Nicole; Finch, Caroline F; Kemp, Joanne L; O'Halloran, Paul D; Gaida, James E
2018-06-01
Physiotherapists promote physical activity as part of their practice. This study reviewed the behaviour change techniques physiotherapists use when promoting physical activity in experimental and observational studies. Systematic review of experimental and observational studies. Twelve databases were searched using terms related to physiotherapy and physical activity. We included experimental studies evaluating the efficacy of physiotherapist-led physical activity interventions delivered to adults in clinic-based private practice and outpatient settings to individuals with, or at risk of, non-communicable diseases. Observational studies reporting the techniques physiotherapists use when promoting physical activity were also included. The behaviour change techniques used in all studies were identified using the Behaviour Change Technique Taxonomy. The behaviour change techniques appearing in efficacious and inefficacious experimental interventions were compared using a narrative approach. Twelve studies (nine experimental and three observational) were retained from the initial search yield of 4141. Risk of bias ranged from low to high. Physiotherapists used seven behaviour change techniques in the observational studies, compared to 30 behaviour change techniques in the experimental studies. Social support (unspecified) was the most frequently identified behaviour change technique across both settings. Efficacious experimental interventions used more behaviour change techniques (n=29) and functioned in more ways (n=6) than did inefficacious experimental interventions (behaviour change techniques=10 and functions=1). Physiotherapists use a small number of behaviour change techniques. Less behaviour change techniques were identified in observational studies compared to experimental studies, suggesting physiotherapists use less BCTs clinically than experimentally. Copyright © 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.
Kang, Sung-Sik; Ofuji, Sosuke; Imai, Kei; Huang, Weiping; Koyama, Keisuke; Yanagawa, Yojiro; Takahashi, Yoshiyuki; Nagano, Masashi
2015-06-01
The aim of the present study was to clarify the efficacy of the well of the well (WOW) culture system for a small number of embryos and the effect of number of adjacent embryos in a WOW dish on blastocyst development. In conventional droplet culture, embryos in the small-number group (5-6 embryos/droplet) showed low blastocyst development compared with a control group (25-26 embryos/droplet). However, small and large numbers of embryos (5-6 and 25 embryos, respectively) in a WOW dish showed no significant differences in cleavage, blastocyst rates, and mean cell number in blastocysts compared with the control group (25-30 embryos/droplet). In addition, the number of adjacent embryos in a WOW dish did not affect the development to blastocysts and cell number in blastocysts. In conclusion, a WOW dish can provide high and stable blastocyst development in small group culture wherever embryos are placed in microwells of the WOW dish.
International Nuclear Information System (INIS)
Amiri-Jaghargh, Ali; Roohi, Ehsan; Niazmand, Hamid; Stefanov, Stefan
2012-01-01
The aim of this study is to extend the validity of the simplified Bernoulli-trials (SBT)/dual grid algorithm, newly proposed by Stefanov, as a suitable alternative of the standard collision scheme in the direct simulation Monte Carlo (DSMC) method, for solving low speed/low Knudsen number rarefied micro/nano flows. The main advantage of the SBT algorithm is to provide accurate calculations using much smaller number of particles per cell, i.e., ≈ 1. Compared to the original development of SBT [1], we extend the application of the SBT scheme to the near continuum rarefied flows, i.e., Kn = 0.005, where NTC scheme requires a relatively large sample size. Comparing the results of the SBT/dual grid scheme with NTC, it is shown that the SBT/dual grid scheme could successfully predict the thermal pattern and hydrodynamics field as well as surface parameters such as velocity slip and temperature jump. Nonlinear flux-corrected transport algorithm (FCT) is also employed as a filter to extract the smooth solution from the noisy DSMC calculation for low-speed/low-Knudsen number DSMC calculations. The results indicate that combination of SBT/dual grid and FTC filtering can decrease the total sample size needed to reach smooth solution without losing significant accuracy.
International Nuclear Information System (INIS)
Michel, A.
1971-01-01
The loops in operation at our Brussels Laboratory installed in Brussels University Applied Mechanics Hall have a maximum capacity of 400 l and a maximum operating temperature of 600 °C. They are equipped with electromagnetic pumps permitting a maximum flow rate of 15 m 3 /h approximately. They are designed for experiments in direct support of our fuel element design group that is e.g. simulation of fuel bundles for temperature distribution measurement, simulation of unloading under argon, etc. In the same lab, BELGONUCLEAIRE also has small sodium test facilities such as under sodium friction test tank. The operational safety of such loops can be described in two parts: design features and operational rules
Webb, S. J.; Manzi, M. S.; Scheiber-Enslin, S. E.; Durrheim, R. J.; Nyblade, A.
2016-12-01
The geophysics program at Wits University has few students in its Honours program, making it difficult to run a fully-fledged field school. However, there is a dire need for field training both at Wits and throughout Africa. The solution is to expand the number of participants by taking additional students from Africa and the US. This has been sponsored by the Society of Exploration Geophysicists (SEG) and more recently UNESCO, and a variety of US NSF programs. More students make it efficient to acquire data using a variety of methods and provides for important networking and skills development. Expanding the number of participants means that more staff members are needed. In Africa, it is difficult to recruit corporate participants as volunteering for three weeks is simply too long to take off from work. Thus university academic staff must commit on an ongoing basis and this can lead to burnout. The timing of the field school is during prime research field time and the results are difficult to publish. The solution has been to use graduate students as instructors. This has turned out to be a valuable experience for graduate students; one or two graduate students are assigned to each method and they take on the responsibility of preparing lectures, equipment, software and computers. Thus the program has developed into a two tier training program, whereby Honours students participate as students with the objective of collecting data and writing a company style report and graduate students participate as instructors. Graduate students participate for one or two years and the payment is mitigated as they are required to work a number of hours for the department. This has led to the establishment of a vibrant network of young geophysicists throughout Africa and the US.
DEFF Research Database (Denmark)
Jakobsen, Janus S; Bagger, Frederik O; Hasemann, Marie S
2015-01-01
BACKGROUND: Chromatin-Immunoprecipitation coupled with deep sequencing (ChIP-seq) is used to map transcription factor occupancy and generate epigenetic profiles genome-wide. The requirement of nano-scale ChIP DNA for generation of sequencing libraries has impeded ChIP-seq on in vivo tissues of low...... transcription factor (CEBPA) and histone mark (H3K4me3) ChIP. We further demonstrate that genomic profiles are highly resilient to changes in carrier DNA to ChIP DNA ratios. CONCLUSIONS: This represents a significant advance compared to existing technologies, which involve either complex steps of pre...... cell numbers. RESULTS: We describe a robust, simple and scalable methodology for ChIP-seq of low-abundant cell populations, verified down to 10,000 cells. By employing non-mammalian genome mapping bacterial carrier DNA during amplification, we reliably amplify down to 50 pg of ChIP DNA from...
DEFF Research Database (Denmark)
Suetens, Sigrid; Galbo-Jørgensen, Claus B.; Tyran, Jean-Robert Karl
2016-01-01
We investigate the ‘law of small numbers’ using a data set on lotto gambling that allows us to measure players’ reactions to draws. While most players pick the same set of numbers week after week, we find that those who do change react on average as predicted by the law of small numbers...... as formalized in recent behavioral theory. In particular, players tend to bet less on numbers that have been drawn in the preceding week, as suggested by the ‘gambler’s fallacy’, and bet more on a number if it was frequently drawn in the recent past, consistent with the ‘hot-hand fallacy’....
Neutrino number of the universe
International Nuclear Information System (INIS)
Kolb, E.W.
1981-01-01
The influence of grand unified theories on the lepton number of the universe is reviewed. A scenario is presented for the generation of a large (>> 1) lepton number and a small (<< 1) baryon number. 15 references
Small Business Procurement Event
2014-08-13
Small Business Procurement Event 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK...NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Department of the Navy,Office of Small Business Programs,720 Kennon...distribution unlimited 13. SUPPLEMENTARY NOTES NDIA 27th Navy Gold Coast Small Business Procurement Event, 12-13 Aug 2014, San Diego, CA. 14. ABSTRACT
Bennett, Ruth, Ed.; And Others
An introduction to the Hupa number system is provided in this workbook, one in a series of numerous materials developed to promote the use of the Hupa language. The book is written in English with Hupa terms used only for the names of numbers. The opening pages present the numbers from 1-10, giving the numeral, the Hupa word, the English word, and…
Indian Academy of Sciences (India)
Admin
Triangular number, figurate num- ber, rangoli, Brahmagupta–Pell equation, Jacobi triple product identity. Figure 1. The first four triangular numbers. Left: Anuradha S Garge completed her PhD from. Pune University in 2008 under the supervision of Prof. S A Katre. Her research interests include K-theory and number theory.
Directory of Open Access Journals (Sweden)
Schwarzweller Christoph
2015-02-01
Full Text Available In this article we introduce Proth numbers and prove two theorems on such numbers being prime [3]. We also give revised versions of Pocklington’s theorem and of the Legendre symbol. Finally, we prove Pepin’s theorem and that the fifth Fermat number is not prime.
Mendonça, J. Ricardo G.
2012-01-01
We define a new class of numbers based on the first occurrence of certain patterns of zeros and ones in the expansion of irracional numbers in a given basis and call them Sagan numbers, since they were first mentioned, in a special case, by the North-american astronomer Carl E. Sagan in his science-fiction novel "Contact." Sagan numbers hold connections with a wealth of mathematical ideas. We describe some properties of the newly defined numbers and indicate directions for further amusement.
DEFF Research Database (Denmark)
Jørgensen, Claus Bjørn; Suetens, Sigrid; Tyran, Jean-Robert
numbers based on recent drawings. While most players pick the same set of numbers week after week without regards of numbers drawn or anything else, we find that those who do change, act on average in the way predicted by the law of small numbers as formalized in recent behavioral theory. In particular......We investigate the “law of small numbers” using a unique panel data set on lotto gambling. Because we can track individual players over time, we can measure how they react to outcomes of recent lotto drawings. We can therefore test whether they behave as if they believe they can predict lotto......, on average they move away from numbers that have recently been drawn, as suggested by the “gambler’s fallacy”, and move toward numbers that are on streak, i.e. have been drawn several weeks in a row, consistent with the “hot hand fallacy”....
Petersen, T Kyle
2015-01-01
This text presents the Eulerian numbers in the context of modern enumerative, algebraic, and geometric combinatorics. The book first studies Eulerian numbers from a purely combinatorial point of view, then embarks on a tour of how these numbers arise in the study of hyperplane arrangements, polytopes, and simplicial complexes. Some topics include a thorough discussion of gamma-nonnegativity and real-rootedness for Eulerian polynomials, as well as the weak order and the shard intersection order of the symmetric group. The book also includes a parallel story of Catalan combinatorics, wherein the Eulerian numbers are replaced with Narayana numbers. Again there is a progression from combinatorics to geometry, including discussion of the associahedron and the lattice of noncrossing partitions. The final chapters discuss how both the Eulerian and Narayana numbers have analogues in any finite Coxeter group, with many of the same enumerative and geometric properties. There are four supplemental chapters throughout, ...
Indian Academy of Sciences (India)
Transfinite Numbers. What is Infinity? S M Srivastava. In a series of revolutionary articles written during the last quarter of the nineteenth century, the great Ger- man mathematician Georg Cantor removed the age-old mistrust of infinity and created an exceptionally beau- tiful and useful theory of transfinite numbers. This is.
Ji, Caleb; Khovanova, Tanya; Park, Robin; Song, Angela
2015-01-01
In this paper, we consider a game played on a rectangular $m \\times n$ gridded chocolate bar. Each move, a player breaks the bar along a grid line. Each move after that consists of taking any piece of chocolate and breaking it again along existing grid lines, until just $mn$ individual squares remain. This paper enumerates the number of ways to break an $m \\times n$ bar, which we call chocolate numbers, and introduces four new sequences related to these numbers. Using various techniques, we p...
Andrews, George E
1994-01-01
Although mathematics majors are usually conversant with number theory by the time they have completed a course in abstract algebra, other undergraduates, especially those in education and the liberal arts, often need a more basic introduction to the topic.In this book the author solves the problem of maintaining the interest of students at both levels by offering a combinatorial approach to elementary number theory. In studying number theory from such a perspective, mathematics majors are spared repetition and provided with new insights, while other students benefit from the consequent simpl
Directory of Open Access Journals (Sweden)
Ellen McCarthy
2009-10-01
Full Text Available Cet article explore comment Margaret Atwood, dans La Voleuse d’hommes (The Robber Bride, 1993, élargit l’éventail des possibilités existantes pour concevoir l’identité nationale anglo-canadienne. Il se concentre sur la façon dont le roman réaborde et reformule certaines des questions sur l’identité canadienne qui sont posées avec insistance dans les premiers récits de fiction et essais critiques d’Atwood. L’article s’intéresse, en particulier, à la manière dont les récits d’évolution personnelle s’entrecroisent avec les discours sur l’identité féminine et canadienne dans La Voleuse d’hommes. Il s’agit d’examiner comment les trajectoires d’évolution personnelle explorées dans le roman attirent l’attention sur la relation complexe entre narration et identité, et d’expliquer comment progrès et évolution, dans les romans, sont influencés ou déterminés par un positionnement politique identitaire nationaliste spécifiquement féministe et canadien.
Barnes, John
2016-01-01
In this intriguing book, John Barnes takes us on a journey through aspects of numbers much as he took us on a geometrical journey in Gems of Geometry. Similarly originating from a series of lectures for adult students at Reading and Oxford University, this book touches a variety of amusing and fascinating topics regarding numbers and their uses both ancient and modern. The author intrigues and challenges his audience with both fundamental number topics such as prime numbers and cryptography, and themes of daily needs and pleasures such as counting one's assets, keeping track of time, and enjoying music. Puzzles and exercises at the end of each lecture offer additional inspiration, and numerous illustrations accompany the reader. Furthermore, a number of appendices provides in-depth insights into diverse topics such as Pascal’s triangle, the Rubik cube, Mersenne’s curious keyboards, and many others. A theme running through is the thought of what is our favourite number. Written in an engaging and witty sty...
International Nuclear Information System (INIS)
Todorov, T.D.
1980-01-01
The set of asymptotic numbers A as a system of generalized numbers including the system of real numbers R, as well as infinitely small (infinitesimals) and infinitely large numbers, is introduced. The detailed algebraic properties of A, which are unusual as compared with the known algebraic structures, are studied. It is proved that the set of asymptotic numbers A cannot be isomorphically embedded as a subspace in any group, ring or field, but some particular subsets of asymptotic numbers are shown to be groups, rings, and fields. The algebraic operation, additive and multiplicative forms, and the algebraic properties are constructed in an appropriate way. It is shown that the asymptotic numbers give rise to a new type of generalized functions quite analogous to the distributions of Schwartz allowing, however, the operation multiplication. A possible application of these functions to quantum theory is discussed
Number names and number understanding
DEFF Research Database (Denmark)
Ejersbo, Lisser Rye; Misfeldt, Morten
2014-01-01
This paper concerns the results from the first year of a three-year research project involving the relationship between Danish number names and their corresponding digits in the canonical base 10 system. The project aims to develop a system to help the students’ understanding of the base 10 syste...... the Danish number names are more complicated than in other languages. Keywords: A research project in grade 0 and 1th in a Danish school, Base-10 system, two-digit number names, semiotic, cognitive perspectives....
Yoo, Seol Bong; Lee, Hyun Ju; Park, Jung Ok; Choe, Gheeyoung; Chung, Doo Hyun; Seo, Jeong-Wook; Chung, Jin-Haeng
2010-03-01
Fluorescence in situ hybridization (FISH) has been known to be the most representative and standardized test for assessing gene amplification. However, FISH requires a fluorescence microscope, the signals are labile and rapidly fade over time. Recently, chromogenic in situ hybridization (CISH) has emerged as a potential alternative to FISH. The aim of this study is to test the reliability of CISH technique for the detection of epidermal growth factor receptor (EGFR) gene amplification in non-small-cell lung carcinomas (NSCLC), to compare CISH results with FISH. A total of 277 formalin-fixed and paraffin embedded NSCLC tissue samples were retrieved from the surgical pathology archives at Seoul National University Bundang Hospital. CISH and FISH examinations were performed to test EGFR gene amplification status. There was high concordance in the assessment of EGFR gene copy number between CISH and FISH tests (Kappa coefficient=0.83). Excellent concordance was shown between two observers on the interpretation of the CISH results (Kappa coefficient=0.90). In conclusion, CISH result is highly reproducible, accurate and practical method to determine EGFR gene amplification in NSCLC. In addition, CISH allows a concurrent analysis of histological features of the tumors and gene copy numbers.
Directory of Open Access Journals (Sweden)
Theodore M. Porter
2012-12-01
Full Text Available The struggle over cure rate measures in nineteenth-century asylums provides an exemplary instance of how, when used for official assessments of institutions, these numbers become sites of contestation. The evasion of goals and corruption of measures tends to make these numbers “funny” in the sense of becoming dis-honest, while the mismatch between boring, technical appearances and cunning backstage manipulations supplies dark humor. The dangers are evident in recent efforts to decentralize the functions of governments and corporations using incen-tives based on quantified targets.
Murty, M Ram
2014-01-01
This book provides an introduction to the topic of transcendental numbers for upper-level undergraduate and graduate students. The text is constructed to support a full course on the subject, including descriptions of both relevant theorems and their applications. While the first part of the book focuses on introducing key concepts, the second part presents more complex material, including applications of Baker’s theorem, Schanuel’s conjecture, and Schneider’s theorem. These later chapters may be of interest to researchers interested in examining the relationship between transcendence and L-functions. Readers of this text should possess basic knowledge of complex analysis and elementary algebraic number theory.
Gaber, Rania; Watermann, Iris; Kugler, Christian; Vollmer, Ekkehard; Perner, Sven; Reck, Martin; Goldmann, Torsten
2017-01-01
Targeting epidermal growth factor receptor (EGFR) in patients with non-small-cell lung cancer (NSCLC) having EGFR mutations is associated with an improved overall survival. The aim of this study is to verify, if EGFR mutations detected by immunohistochemistry (IHC) is a convincing way to preselect patients for DNA-sequencing and to figure out, the statistical association between EGFR mutation, wild-type EGFR overexpression, gene copy number gain, which are the main factors inducing EGFR tumorigenic activity and the clinicopathological data. Two hundred sixteen tumor tissue samples of primarily chemotherapeutic naïve NSCLC patients were analyzed for EGFR mutations E746-A750del and L858R and correlated with DNA-sequencing. Two hundred six of which were assessed by IHC, using 6B6 and 43B2 specific antibodies followed by DNA-sequencing of positive cases and 10 already genotyped tumor tissues were also included to investigate debugging accuracy of IHC. In addition, EGFR wild-type overexpression was IHC evaluated and EGFR gene copy number determination was performed by fluorescence in situ hybridization (FISH). Forty-one÷206 (19.9%) cases were positive for mutated EGFR by IHC. Eight of them had EGFR mutations of exons 18-21 by DNA-sequencing. Hit rate of 10 already genotyped NSCLC mutated cases was 90% by IHC. Positive association was found between EGFR mutations determined by IHC and both EGFR overexpression and increased gene copy number (p=0.002 and p<0.001, respectively). Additionally, positive association was detected between EGFR mutations, high tumor grade and clinical stage (p<0.001). IHC staining with mutation specific antibodies was demonstrated as a possible useful screening test to preselect patients for DNA-sequencing.
Indian Academy of Sciences (India)
this is a characteristic difference between finite and infinite sets and created an immensely useful branch of mathematics based on this idea which had a great impact on the whole of mathe- matics. For example, the question of what is a number (finite or infinite) is almost a philosophical one. However Cantor's work turned it ...
Directory of Open Access Journals (Sweden)
Terrenato Irene
2010-09-01
Full Text Available Abstract Background Several studies demonstrated that epidermal growth factor receptor (EGFR gene copy number (GCN correlates to the response to tyrosine kinase inhibitors in non small cell lung cancer (NSCLC and to anti-EGFR monoclonal antibodies (MoAbs in metastatic colorectal cancer (CRC. In the presence of lung nodules, cytology is often the only possible diagnostic approach. Chromogenic in situ hybridization (CISH is an alternative technique to fluorescence in situ hybridization (FISH, but its feasibility in detecting EGFR GCN in cell blocks from fine-needle aspiration cytology (FNAC of lung nodules has not yet been established. Methods We evaluated the feasibility of CISH on 33 FNAC from 20 primary NSCLC (5 squamous carcinomas, 8 large cell carcinomas and 7 adenocarcinomas and 13 lung metastases from CRC. Results Of the 33 FNAC analyzed by CISH, 27 (82% presented a balanced increase in EGFR gene and chromosome 7 number: 10 cases (30% showed a low polysomy, 15 (45% a high polysomy and 2 (6% NSCLC were amplified. No significant differences between NSCLC and CRC lung metastases were found in relation to disomic or polysomic status. In addition, no correlation between EGFR GCN and EGFR immunohistochemical overexpression was found. Furthermore, we compared CISH results with those obtained by FISH on the same samples and we found 97% overall agreement between the two assays (k = 0.78, p Conclusions Our study shows that CISH is a valid method to detect EGFR GCN in cell blocks from FNAC of primary NSCLC or metastatic CRC to the lung.
Würschum, Tobias; Langer, Simon M; Longin, C Friedrich H; Tucker, Matthew R; Leiser, Willmar L
2018-06-01
The broad adaptability of heading time has contributed to the global success of wheat in a diverse array of climatic conditions. Here, we investigated the genetic architecture underlying heading time in a large panel of 1,110 winter wheat cultivars of worldwide origin. Genome-wide association mapping, in combination with the analysis of major phenology loci, revealed a three-component system that facilitates the adaptation of heading time in winter wheat. The photoperiod sensitivity locus Ppd-D1 was found to account for almost half of the genotypic variance in this panel and can advance or delay heading by many days. In addition, copy number variation at Ppd-B1 was the second most important source of variation in heading, explaining 8.3% of the genotypic variance. Results from association mapping and genomic prediction indicated that the remaining variation is attributed to numerous small-effect quantitative trait loci that facilitate fine-tuning of heading to the local climatic conditions. Collectively, our results underpin the importance of the two Ppd-1 loci for the adaptation of heading time in winter wheat and illustrate how the three components have been exploited for wheat breeding globally. © 2018 John Wiley & Sons Ltd.
Murakami, Kentaro; Livingstone, M Barbara E
2016-01-28
Evidence of associations between meal frequency (MF) and snack frequency (SF) and diet and obesity in young populations is limited. This cross-sectional study examined MF and SF in relation to dietary intake and adiposity measures in British children aged 4-10 years (n 818) and adolescents aged 11-18 years (n 818). Based on data from a 7-d weighed dietary record, all eating occasions were divided into meals or snacks on the basis of contribution to energy intake (≥15 or total sugar, lower intakes of cereals, fish, meat, protein, PUFA, starch and dietary fibre, and a lower diet quality (assessed by the Mediterranean diet score, except for SF based on energy contribution in adolescents). MF based on time, but not based on energy contribution, was associated with higher intakes of confectionery and total sugar, lower intakes of fish, protein, PUFA and starch, and, only in children, a lower diet quality. All measures of MF and SF showed no association with adiposity measures. In conclusion, this cross-sectional study in British children and adolescents suggests that decreasing the number of small eating occasions (total energy intake) regardless of the time of day may be important to improve diet quality but not adiposity.
78 FR 48537 - Small Business Innovation Research and Small Business Technology Transfer Programs...
2013-08-08
... SMALL BUSINESS ADMINISTRATION [Docket Number: 2013-0008] Small Business Innovation Research and Small Business Technology Transfer Programs Commercialization Benchmark AGENCY: Small Business Administration. ACTION: Notice. SUMMARY: The Small Business Administration (SBA) is publishing the Small Business...
Schwartz, Richard Evan
2014-01-01
In the American Mathematical Society's first-ever book for kids (and kids at heart), mathematician and author Richard Evan Schwartz leads math lovers of all ages on an innovative and strikingly illustrated journey through the infinite number system. By means of engaging, imaginative visuals and endearing narration, Schwartz manages the monumental task of presenting the complex concept of Big Numbers in fresh and relatable ways. The book begins with small, easily observable numbers before building up to truly gigantic ones, like a nonillion, a tredecillion, a googol, and even ones too huge for names! Any person, regardless of age, can benefit from reading this book. Readers will find themselves returning to its pages for a very long time, perpetually learning from and growing with the narrative as their knowledge deepens. Really Big Numbers is a wonderful enrichment for any math education program and is enthusiastically recommended to every teacher, parent and grandparent, student, child, or other individual i...
Earthquake number forecasts testing
Kagan, Yan Y.
2017-10-01
We study the distributions of earthquake numbers in two global earthquake catalogues: Global Centroid-Moment Tensor and Preliminary Determinations of Epicenters. The properties of these distributions are especially required to develop the number test for our forecasts of future seismic activity rate, tested by the Collaboratory for Study of Earthquake Predictability (CSEP). A common assumption, as used in the CSEP tests, is that the numbers are described by the Poisson distribution. It is clear, however, that the Poisson assumption for the earthquake number distribution is incorrect, especially for the catalogues with a lower magnitude threshold. In contrast to the one-parameter Poisson distribution so widely used to describe earthquake occurrences, the negative-binomial distribution (NBD) has two parameters. The second parameter can be used to characterize the clustering or overdispersion of a process. We also introduce and study a more complex three-parameter beta negative-binomial distribution. We investigate the dependence of parameters for both Poisson and NBD distributions on the catalogue magnitude threshold and on temporal subdivision of catalogue duration. First, we study whether the Poisson law can be statistically rejected for various catalogue subdivisions. We find that for most cases of interest, the Poisson distribution can be shown to be rejected statistically at a high significance level in favour of the NBD. Thereafter, we investigate whether these distributions fit the observed distributions of seismicity. For this purpose, we study upper statistical moments of earthquake numbers (skewness and kurtosis) and compare them to the theoretical values for both distributions. Empirical values for the skewness and the kurtosis increase for the smaller magnitude threshold and increase with even greater intensity for small temporal subdivision of catalogues. The Poisson distribution for large rate values approaches the Gaussian law, therefore its skewness
DEFF Research Database (Denmark)
Holgersen, Sven-Erik; Bruun, Peter; Tjagvad, Mette
2018-01-01
the study: What expectations do the class teacher and the professional musicians have to the creative practice, i.e. to the collaboration and to the musical outcome? To which extent do the collaborating partners share a common understanding of the aim, content and method of the workshop? How do the roles......The present chapter discusses roles and responsibilities of the collaborating partners in a creative music workshop called Small Composers. The aim is to be attentive to a number of potential alterations implicated by the collaborating partners’ different backgrounds. The following questions guided...... and responsibilities of the collaborating partners become visible through the practice? How do the professional identities of the teacher and the musicians become visible and what are the implications for the workshop as a musical community of practice?...
78 FR 59410 - Small Business Innovation Research and Small Business Technology Transfer Programs...
2013-09-26
... SMALL BUSINESS ADMINISTRATION [Docket Number: 2013-0008] Small Business Innovation Research and Small Business Technology Transfer Programs Commercialization Benchmark AGENCY: Small Business... Business Administration (SBA) is reopening the comment period for the Small Business Innovation Research...
Directory of Open Access Journals (Sweden)
Abhijit Paul
2016-09-01
Full Text Available Present article illustrates a computational study of three-dimensional steady state heat transfer and high turbulent flow characteristics through a rectangular duct with constant heat fluxed upper wall and single rectangular cross-sectioned baffle insertion at different angles. RNG k–ɛ model along with standard wall function based computations has been accomplished applying the finite volume method, and SIMPLE algorithm has been executed for solving the governing equations. For a Reynolds number, Re of 10,000 to 50,000, Prandtl Number, Pr of 0.707 and baffle angle, α of 30°, 60°, 90°, 120°, 150°, computational studies are executed, centred onto the hydraulic diameter, Dh, test section and hydrodynamic entry length of the duct. Flow field has been solved using Ansys Fluent 14.0 software. Study exposes that baffled rectangular duct has a higher average Nusselt number, Nu and Darcy friction factor, f compared to a smooth rectangular duct. Nu as well as f are found to be maximum at 90° baffle angle. Results illustrate that both α and Re play a significant role in heat transfer as well as flow characteristics and also effects TEF. The correctness of the results attained in this study is corroborated by comparing the results with those existing in the literature for smooth rectangular duct within a precision of ±2% for f and ±4% for Nu.
Number Sense on the Number Line
Woods, Dawn Marie; Ketterlin Geller, Leanne; Basaraba, Deni
2018-01-01
A strong foundation in early number concepts is critical for students' future success in mathematics. Research suggests that visual representations, like a number line, support students' development of number sense by helping them create a mental representation of the order and magnitude of numbers. In addition, explicitly sequencing instruction…
S. Pemberton (Steven)
2014-01-01
htmlabstractThe term “Open Data” often goes hand in hand with the term “Big Data”, where large data sets get released allowing for analysis, but the Cinderella of the Open Data ball is Small Data, small amounts of data, nonetheless possibly essential, that are too small to be put in some database or
Richardson, Thomas M.
2014-01-01
We introduce the super Patalan numbers, a generalization of the super Catalan numbers in the sense of Gessel, and prove a number of properties analagous to those of the super Catalan numbers. The super Patalan numbers generalize the super Catalan numbers similarly to how the Patalan numbers generalize the Catalan numbers.
Visuospatial Priming of the Mental Number Line
Stoianov, Ivilin; Kramer, Peter; Umilta, Carlo; Zorzi, Marco
2008-01-01
It has been argued that numbers are spatially organized along a "mental number line" that facilitates left-hand responses to small numbers, and right-hand responses to large numbers. We hypothesized that whenever the representations of visual and numerical space are concurrently activated, interactions can occur between them, before response…
Gu, Yuanlong; Lv, Huimin; Zhao, Juan; Li, Qi; Mu, Guannan; Li, Jiade; Wuyang, Jiazi; Lou, Ge; Wang, Ruitao; Zhang, Yanqiao; Huang, Xiaoyi
2017-09-01
Cytokine-induced killer (CIK) cells have important therapeutic effects in adoptive cell transfer (ACT) for the treatment of various malignancies. In this study, we focused on in vitro expansion of CIK cells and their clinical efficacy in combination with chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC). A total of 64 patients with NSCLC (enrolled from 2011 to 2012), including 32 patients who received chemotherapy alone or with sequential radiotherapy (conventional treatment, control group) and 32 patients who received conventional treatment and sequential CIK infusion (study group), were retrospectively analyzed. The time to progression (TTP), overall survival (OS) and adverse effects were analyzed and the phenotype of lymphocytes in CIK population was also determined by flow cytometry. After in vitro expansion, the average percentage of CIK cells was 26.35%. During the 54-month follow up, the median OS and TTP were significantly longer in the study group than in the control group (P=0.0189 and P=0.0129, respectively). The median OS of the ACT≥4cycles subgroup was significantly longer than that of the ACTcells in patients who received ≥4cycles of ACT was higher than that in patients treated with cells were difficult to expand in vitro in some patients after the first ACT cycle but became much easier as the treatment cycles increased monthly. Longer treatment interval negatively impacted the expansion of CIK cells. Systematic immune levels can be increasingly boosted by reinfusion of ACT. Conventional treatment plus CIK cells is an effective therapeutic strategy to prevent progression and prolong survival of patients with advanced NSCLC. Copyright © 2017. Published by Elsevier B.V.
Pemberton, Steven
2014-01-01
htmlabstractThe term “Open Data” often goes hand in hand with the term “Big Data”, where large data sets get released allowing for analysis, but the Cinderella of the Open Data ball is Small Data, small amounts of data, nonetheless possibly essential, that are too small to be put in some database or online dataset to be put to use. RDFa is a technology that allows Cinderella to go to the ball.
International Nuclear Information System (INIS)
Bennett, K.; Tung, T.
1995-01-01
A small hydro plant in Canada is defined as any project between 1 MW and 15 MW but the international standard is 10 MW. The global market for small hydro development was considered good. There are some 1000 to 2000 MW of generating capacity being added each year. In Canada, growth potential is considered small, primarily in remote areas, but significant growth is anticipated in Eastern Europe, Africa and Asia. Canada with its expertise in engineering, manufacturing and development is considered to have a good chance to take advantage of these growing markets
Number words and number symbols a cultural history of numbers
Menninger, Karl
1992-01-01
Classic study discusses number sequence and language and explores written numerals and computations in many cultures. "The historian of mathematics will find much to interest him here both in the contents and viewpoint, while the casual reader is likely to be intrigued by the author's superior narrative ability.
Alternative analysis: the prime numbers theory and an extension of the real numbers set
Sukhotin A.; Zvyagin M.
2016-01-01
Here we consider the theory of prime numbers at a new methodology. The theory of prime numbers is one of the most ancient mathematical branches. We found an estimate of the all prime numbers sum using the notions of infinite lager numbers and infinitely small numbers, farther we estimated the value of the maximal prime number. We proved that Hardy–Littlewood Hypothesis has the positive decision too. The infinite small numbers define a new methodology of the well–known function o(x) applicatio...
Number to finger mapping is topological.
Plaisier, M.A.; Smeets, J.B.J.
2011-01-01
It has been shown that humans associate fingers with numbers because finger counting strategies interact with numerical judgements. At the same time, there is evidence that there is a relation between number magnitude and space as small to large numbers seem to be represented from left to right. In
Laws of small numbers extremes and rare events
Falk, Michael; Hüsler, Jürg
2004-01-01
Since the publication of the first edition of this seminar book in 1994, the theory and applications of extremes and rare events have enjoyed an enormous and still increasing interest. The intention of the book is to give a mathematically oriented development of the theory of rare events underlying various applications. This characteristic of the book was strengthened in the second edition by incorporating various new results on about 130 additional pages. Part II, which has been added in the second edition, discusses recent developments in multivariate extreme value theory. Particularly notable is a new spectral decomposition of multivariate distributions in univariate ones which makes multivariate questions more accessible in theory and practice. One of the most innovative and fruitful topics during the last decades was the introduction of generalized Pareto distributions in the univariate extreme value theory. Such a statistical modelling of extremes is now systematically developed in the multivariate fram...
Simulation and study of small numbers of random events
Shelton, R. D.
1986-01-01
Random events were simulated by computer and subjected to various statistical methods to extract important parameters. Various forms of curve fitting were explored, such as least squares, least distance from a line, maximum likelihood. Problems considered were dead time, exponential decay, and spectrum extraction from cosmic ray data using binned data and data from individual events. Computer programs, mostly of an iterative nature, were developed to do these simulations and extractions and are partially listed as appendices. The mathematical basis for the compuer programs is given.
Cardinal Equivalence of Small Number in Young Children.
Kingma, J.; Roelinga, U.
1982-01-01
Children completed three types of equivalent cardination tasks which assessed the influence of different stimulus configurations (linear, linear-nonlinear, and nonlinear), and density of object spacing. Prior results reported by Siegel, Brainerd, and Gelman and Gallistel were not replicated. Implications for understanding cardination concept…
Laws of small numbers extremes and rare events
Falk, Michael; Reiss, Rolf-Dieter
2011-01-01
Since the publication of the first edition of this seminar book in 1994, the theory and applications of extremes and rare events have enjoyed an enormous and still increasing interest. The intention of the book is to give a mathematically oriented development of the theory of rare events underlying various applications. This characteristic of the book was strengthened in the second edition by incorporating various new results. In this third edition, the dramatic change of focus of extreme value theory has been taken into account: from concentrating on maxima of observations it has shifted to l
Directory of Open Access Journals (Sweden)
T. Pathinathan
2015-01-01
Full Text Available In this paper we define diamond fuzzy number with the help of triangular fuzzy number. We include basic arithmetic operations like addition, subtraction of diamond fuzzy numbers with examples. We define diamond fuzzy matrix with some matrix properties. We have defined Nested diamond fuzzy number and Linked diamond fuzzy number. We have further classified Right Linked Diamond Fuzzy number and Left Linked Diamond Fuzzy number. Finally we have verified the arithmetic operations for the above mentioned types of Diamond Fuzzy Numbers.
Koninck, Jean-Marie De
2009-01-01
Who would have thought that listing the positive integers along with their most remarkable properties could end up being such an engaging and stimulating adventure? The author uses this approach to explore elementary and advanced topics in classical number theory. A large variety of numbers are contemplated: Fermat numbers, Mersenne primes, powerful numbers, sublime numbers, Wieferich primes, insolite numbers, Sastry numbers, voracious numbers, to name only a few. The author also presents short proofs of miscellaneous results and constantly challenges the reader with a variety of old and new n
Radiotherapy in small countries.
Barton, Michael B; Zubizarreta, Eduardo H; Polo Rubio, J Alfredo
2017-10-01
To examine the availability of radiotherapy in small countries. A small country was defined as a country with a population less than one million persons. The economic status of each country was defined using the World Bank Classification. The number of cancers in each country was obtained from GLOBOCAN 2012. The number of cancer cases with an indication or radiotherapy was calculated using the CCORE model. There were 41 countries with a population of under 1 million; 15 were classified as High Income, 15 Upper Middle Income, 10 Lower Middle Income and one Low Income. 28 countries were islands. Populations ranged from 799 (Holy See) to 886450 (Fiji) and the total number of cancer cases occurring in small countries was 21,043 (range by country from 4 to 2476). Overall the total number of radiotherapy cases in small countries was 10982 (range by country from 2 to 1239). Radiotherapy was available in all HIC islands with 80 or more new cases of cancer in 2012 but was not available in any LMIC island. Fiji was the only LMIC island with a large radiotherapy caseload. Similar caseloads in non-island LMIC all had radiotherapy services. Most non-island HIC did not have radiotherapy services presumably because of the easy access to radiotherapy in neighbouring countries. There are no radiotherapy services in any LMIC islands. Copyright © 2017. Published by Elsevier Ltd.
Lepton family number violation
International Nuclear Information System (INIS)
Herczeg, P.
1999-01-01
At present there is evidence from neutrino oscillation searches that the neutrinos are in fact massive particles and that they mix. If confirmed, this would imply that the conservation of LFN is not exact. Lepton family number violation (LFNV) has been searched for with impressive sensitivities in many processes involving charged leptons. The present experimental limits on some of them (those which the author shall consider here) are shown in Table 1. These stringent limits are not inconsistent with the neutrino oscillation results since, given the experimental bounds on the masses of the known neutrinos and the neutrino mass squared differences required by the oscillation results, the effects of LFNV from neutrino mixing would be too small to be seen elsewhere (see Section 2). The purpose of experiments searching for LFNV involving the charged leptons is to probe the existence of other sources of LFNV. Such sources are present in many extensions of the SM. In this lecture the author shall discuss some of the possibilities, focusing on processes that require muon beams. Other LFNV processes, such as the decays of the kaons and of the τ, provide complementary information. In the next Section he shall consider some sources of LFNV that do not require an extension of the gauge group of the SM (the added leptons or Higgs bosons may of course originate from models with extended gauge groups). In Section 3 he discusses LFNV in left-right symmetric models. In Section 4 he considers LFNV in supersymmetric models, first in R-parity conserving supersymmetric grand unified models, and then in the minimal supersymmetric standard model with R-parity violation. The last section is a brief summary of the author's conclusions
Burkhart, Jerry
2009-01-01
Prime numbers are often described as the "building blocks" of natural numbers. This article shows how the author and his students took this idea literally by using prime factorizations to build numbers with blocks. In this activity, students explore many concepts of number theory, including the relationship between greatest common factors and…
Vazzana, Anthony; Garth, David
2007-01-01
One of the oldest branches of mathematics, number theory is a vast field devoted to studying the properties of whole numbers. Offering a flexible format for a one- or two-semester course, Introduction to Number Theory uses worked examples, numerous exercises, and two popular software packages to describe a diverse array of number theory topics.
On the number of special numbers
Indian Academy of Sciences (India)
without loss of any generality to be the first k primes), then the equation a + b = c has .... This is an elementary exercise in partial summation (see [12]). Thus ... This is easily done by inserting a stronger form of the prime number theorem into the.
Dimensionless numbers in additive manufacturing
Mukherjee, T.; Manvatkar, V.; De, A.; DebRoy, T.
2017-02-01
The effects of many process variables and alloy properties on the structure and properties of additively manufactured parts are examined using four dimensionless numbers. The structure and properties of components made from 316 Stainless steel, Ti-6Al-4V, and Inconel 718 powders for various dimensionless heat inputs, Peclet numbers, Marangoni numbers, and Fourier numbers are studied. Temperature fields, cooling rates, solidification parameters, lack of fusion defects, and thermal strains are examined using a well-tested three-dimensional transient heat transfer and fluid flow model. The results show that lack of fusion defects in the fabricated parts can be minimized by strengthening interlayer bonding using high values of dimensionless heat input. The formation of harmful intermetallics such as laves phases in Inconel 718 can be suppressed using low heat input that results in a small molten pool, a steep temperature gradient, and a fast cooling rate. Improved interlayer bonding can be achieved at high Marangoni numbers, which results in vigorous circulation of liquid metal, larger pool dimensions, and greater depth of penetration. A high Fourier number ensures rapid cooling, low thermal distortion, and a high ratio of temperature gradient to the solidification growth rate with a greater tendency of plane front solidification.
Grešak, Rozalija
2015-01-01
The field of real numbers is usually constructed using Dedekind cuts. In these thesis we focus on the construction of the field of real numbers using metric completion of rational numbers using Cauchy sequences. In a similar manner we construct the field of p-adic numbers, describe some of their basic and topological properties. We follow by a construction of complex p-adic numbers and we compare them with the ordinary complex numbers. We conclude the thesis by giving a motivation for the int...
On the number of special numbers
Indian Academy of Sciences (India)
We now apply the theory of the Thue equation to obtain an effective bound on m. Indeed, by Lemma 3.2, we can write m2 = ba3 and m2 − 4 = cd3 with b, c cubefree. By the above, both b, c are bounded since they are cubefree and all their prime factors are less than e63727. Now we have a finite number of. Thue equations:.
International Nuclear Information System (INIS)
Kaneko, K.
1987-01-01
A relationship between the number projection and the shell model methods is investigated in the case of a single-j shell. We can find a one-to-one correspondence between the number projected and the shell model states
Gallistel, C R
2017-12-01
The representation of discrete and continuous quantities appears to be ancient and pervasive in animal brains. Because numbers are the natural carriers of these representations, we may discover that in brains, it's numbers all the way down.
DEFF Research Database (Denmark)
Andersen, Torben
2014-01-01
had a marked singular and an unmarked plural. Synchronically, however, the singular is arguably the basic member of the number category as revealed by the use of the two numbers. In addition, some nouns have a collective form, which is grammatically singular. Number also plays a role...
DEFF Research Database (Denmark)
Elvik, Rune; Bjørnskau, Torkel
2017-01-01
Highlights •26 studies of the safety-in-numbers effect are reviewed. •The existence of a safety-in-numbers effect is confirmed. •Results are consistent. •Causes of the safety-in-numbers effect are incompletely known....
de Mestre, Neville
2008-01-01
Prime numbers are important as the building blocks for the set of all natural numbers, because prime factorisation is an important and useful property of all natural numbers. Students can discover them by using the method known as the Sieve of Eratosthenes, named after the Greek geographer and astronomer who lived from c. 276-194 BC. Eratosthenes…
Niederreiter, Harald
2015-01-01
This textbook effectively builds a bridge from basic number theory to recent advances in applied number theory. It presents the first unified account of the four major areas of application where number theory plays a fundamental role, namely cryptography, coding theory, quasi-Monte Carlo methods, and pseudorandom number generation, allowing the authors to delineate the manifold links and interrelations between these areas. Number theory, which Carl-Friedrich Gauss famously dubbed the queen of mathematics, has always been considered a very beautiful field of mathematics, producing lovely results and elegant proofs. While only very few real-life applications were known in the past, today number theory can be found in everyday life: in supermarket bar code scanners, in our cars’ GPS systems, in online banking, etc. Starting with a brief introductory course on number theory in Chapter 1, which makes the book more accessible for undergraduates, the authors describe the four main application areas in Chapters...
Understanding the statistics of small risks
International Nuclear Information System (INIS)
Siddall, E.
1983-10-01
Monte Carlo analyses are used to show what inferences can and cannot be drawn when either a very small number of accidents result from a considerable exposure or where a very small number of people, down to a single individual, are exposed to small added risks. The distinction between relative and absolute uncertainty is illustrated. No new statistical principles are involved
Ore, Oystein
2017-01-01
Number theory is the branch of mathematics concerned with the counting numbers, 1, 2, 3, … and their multiples and factors. Of particular importance are odd and even numbers, squares and cubes, and prime numbers. But in spite of their simplicity, you will meet a multitude of topics in this book: magic squares, cryptarithms, finding the day of the week for a given date, constructing regular polygons, pythagorean triples, and many more. In this revised edition, John Watkins and Robin Wilson have updated the text to bring it in line with contemporary developments. They have added new material on Fermat's Last Theorem, the role of computers in number theory, and the use of number theory in cryptography, and have made numerous minor changes in the presentation and layout of the text and the exercises.
Douhou, S.; Magnus, J.R.; van Soest, A.H.O.
2011-01-01
In this paper we measure perceptions of incorrect behavior or ‘small crime’, based on a questionnaire administered to a large representative sample from the Dutch population. In the questionnaire we ask the respondents to rate the severity or justifiability of a number of small crimes. We present
Benthic invertebrate fauna, small streams
J. Bruce Wallace; S.L. Eggert
2009-01-01
Small streams (first- through third-order streams) make up >98% of the total number of stream segments and >86% of stream length in many drainage networks. Small streams occur over a wide array of climates, geology, and biomes, which influence temperature, hydrologic regimes, water chemistry, light, substrate, stream permanence, a basin's terrestrial plant...
Small circuits for cryptography.
Energy Technology Data Exchange (ETDEWEB)
Torgerson, Mark Dolan; Draelos, Timothy John; Schroeppel, Richard Crabtree; Miller, Russell D.; Anderson, William Erik
2005-10-01
This report examines a number of hardware circuit design issues associated with implementing certain functions in FPGA and ASIC technologies. Here we show circuit designs for AES and SHA-1 that have an extremely small hardware footprint, yet show reasonably good performance characteristics as compared to the state of the art designs found in the literature. Our AES performance numbers are fueled by an optimized composite field S-box design for the Stratix chipset. Our SHA-1 designs use register packing and feedback functionalities of the Stratix LE, which reduce the logic element usage by as much as 72% as compared to other SHA-1 designs.
Godefroy, Gilles
2004-01-01
Numbers are fascinating. The fascination begins in childhood, when we first learn to count. It continues as we learn arithmetic, algebra, geometry, and so on. Eventually, we learn that numbers not only help us to measure the world, but also to understand it and, to some extent, to control it. In The Adventure of Numbers, Gilles Godefroy follows the thread of our expanding understanding of numbers to lead us through the history of mathematics. His goal is to share the joy of discovering and understanding this great adventure of the mind. The development of mathematics has been punctuated by a n
Diamond, Harold G; Cheung, Man Ping
2016-01-01
"Generalized numbers" is a multiplicative structure introduced by A. Beurling to study how independent prime number theory is from the additivity of the natural numbers. The results and techniques of this theory apply to other systems having the character of prime numbers and integers; for example, it is used in the study of the prime number theorem (PNT) for ideals of algebraic number fields. Using both analytic and elementary methods, this book presents many old and new theorems, including several of the authors' results, and many examples of extremal behavior of g-number systems. Also, the authors give detailed accounts of the L^2 PNT theorem of J. P. Kahane and of the example created with H. L. Montgomery, showing that additive structure is needed for proving the Riemann hypothesis. Other interesting topics discussed are propositions "equivalent" to the PNT, the role of multiplicative convolution and Chebyshev's prime number formula for g-numbers, and how Beurling theory provides an interpretation of the ...
Intuitive numbers guide decisions
Directory of Open Access Journals (Sweden)
Ellen Peters
2008-12-01
Full Text Available Measuring reaction times to number comparisons is thought to reveal a processing stage in elementary numerical cognition linked to internal, imprecise representations of number magnitudes. These intuitive representations of the mental number line have been demonstrated across species and human development but have been little explored in decision making. This paper develops and tests hypotheses about the influence of such evolutionarily ancient, intuitive numbers on human decisions. We demonstrate that individuals with more precise mental-number-line representations are higher in numeracy (number skills consistent with previous research with children. Individuals with more precise representations (compared to those with less precise representations also were more likely to choose larger, later amounts over smaller, immediate amounts, particularly with a larger proportional difference between the two monetary outcomes. In addition, they were more likely to choose an option with a larger proportional but smaller absolute difference compared to those with less precise representations. These results are consistent with intuitive number representations underlying: a perceived differences between numbers, b the extent to which proportional differences are weighed in decisions, and, ultimately, c the valuation of decision options. Human decision processes involving numbers important to health and financial matters may be rooted in elementary, biological processes shared with other species.
Hirst, Keith
1994-01-01
Number and geometry are the foundations upon which mathematics has been built over some 3000 years. This book is concerned with the logical foundations of number systems from integers to complex numbers. The author has chosen to develop the ideas by illustrating the techniques used throughout mathematics rather than using a self-contained logical treatise. The idea of proof has been emphasised, as has the illustration of concepts from a graphical, numerical and algebraic point of view. Having laid the foundations of the number system, the author has then turned to the analysis of infinite proc
Large number discrimination by mosquitofish.
Directory of Open Access Journals (Sweden)
Christian Agrillo
Full Text Available BACKGROUND: Recent studies have demonstrated that fish display rudimentary numerical abilities similar to those observed in mammals and birds. The mechanisms underlying the discrimination of small quantities (<4 were recently investigated while, to date, no study has examined the discrimination of large numerosities in fish. METHODOLOGY/PRINCIPAL FINDINGS: Subjects were trained to discriminate between two sets of small geometric figures using social reinforcement. In the first experiment mosquitofish were required to discriminate 4 from 8 objects with or without experimental control of the continuous variables that co-vary with number (area, space, density, total luminance. Results showed that fish can use the sole numerical information to compare quantities but that they preferentially use cumulative surface area as a proxy of the number when this information is available. A second experiment investigated the influence of the total number of elements to discriminate large quantities. Fish proved to be able to discriminate up to 100 vs. 200 objects, without showing any significant decrease in accuracy compared with the 4 vs. 8 discrimination. The third experiment investigated the influence of the ratio between the numerosities. Performance was found to decrease when decreasing the numerical distance. Fish were able to discriminate numbers when ratios were 1:2 or 2:3 but not when the ratio was 3:4. The performance of a sample of undergraduate students, tested non-verbally using the same sets of stimuli, largely overlapped that of fish. CONCLUSIONS/SIGNIFICANCE: Fish are able to use pure numerical information when discriminating between quantities larger than 4 units. As observed in human and non-human primates, the numerical system of fish appears to have virtually no upper limit while the numerical ratio has a clear effect on performance. These similarities further reinforce the view of a common origin of non-verbal numerical systems in all
Templates, Numbers & Watercolors.
Clemesha, David J.
1990-01-01
Describes how a second-grade class used large templates to draw and paint five-digit numbers. The lesson integrated artistic knowledge and vocabulary with their mathematics lesson in place value. Students learned how draftspeople use templates, and they studied number paintings by Charles Demuth and Jasper Johns. (KM)
Directory of Open Access Journals (Sweden)
Ryszard Przybylski
2016-12-01
Full Text Available The poem Small talk conjures up a communicative situation in which the main character, a newcomer from Poland, answers conventional questions related to their country. Bearing in mind the fact that this poem is set during a military dictatorship, superficial interest in his homeland may trigger a feeling of impatience. This is at least the impression formed if we adopt the perspective defined within the romantic tradition, and when taking into account the conventional poetry of martial law in Poland. Nevertheless, Barańczak retains an ironic distance towards such communicative situations and, as a consequence, does not create poetry that meets most readersʼ expectations. His poetic imperative for verbal art to be the expression of mistrust remains valid.
Rayleigh-Taylor instability in the presence of a density transition layer
International Nuclear Information System (INIS)
Tavakoli, A.; Tskhakaya, D.D.; Tsintsadze, N.L.
1999-01-01
A new type of symmetry for the Rayleigh equation is found. For small Atwood number an analytic solution is obtained for a smoothly varying density profile. The spectra of unstable modes are defined. It is shown that a transition layer with finite width can undergo stratification, and velocity shear between new-formed sublayers forms. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)
Small white matter lesion detection in cerebral small vessel disease
Ghafoorian, Mohsen; Karssemeijer, Nico; van Uden, Inge; de Leeuw, Frank E.; Heskes, Tom; Marchiori, Elena; Platel, Bram
2015-03-01
Cerebral small vessel disease (SVD) is a common finding on magnetic resonance images of elderly people. White matter lesions (WML) are important markers for not only the small vessel disease, but also neuro-degenerative diseases including multiple sclerosis, Alzheimer's disease and vascular dementia. Volumetric measurements such as the "total lesion load", have been studied and related to these diseases. With respect to SVD we conjecture that small lesions are important, as they have been observed to grow over time and they form the majority of lesions in number. To study these small lesions they need to be annotated, which is a complex and time-consuming task. Existing (semi) automatic methods have been aimed at volumetric measurements and large lesions, and are not suitable for the detection of small lesions. In this research we established a supervised voxel classification CAD system, optimized and trained to exclusively detect small WMLs. To achieve this, several preprocessing steps were taken, which included a robust standardization of subject intensities to reduce inter-subject intensity variability as much as possible. A number of features that were found to be well identifying small lesions were calculated including multimodal intensities, tissue probabilities, several features for accurate location description, a number of second order derivative features as well as multi-scale annular filter for blobness detection. Only small lesions were used to learn the target concept via Adaboost using random forests as its basic classifiers. Finally the results were evaluated using Free-response receiver operating characteristic.
International Nuclear Information System (INIS)
Coveyou, R.R.
1974-01-01
The subject of random number generation is currently controversial. Differing opinions on this subject seem to stem from implicit or explicit differences in philosophy; in particular, from differing ideas concerning the role of probability in the real world of physical processes, electronic computers, and Monte Carlo calculations. An attempt is made here to reconcile these views. The role of stochastic ideas in mathematical models is discussed. In illustration of these ideas, a mathematical model of the use of random number generators in Monte Carlo calculations is constructed. This model is used to set up criteria for the comparison and evaluation of random number generators. (U.S.)
Weiss, Edwin
1998-01-01
Careful organization and clear, detailed proofs characterize this methodical, self-contained exposition of basic results of classical algebraic number theory from a relatively modem point of view. This volume presents most of the number-theoretic prerequisites for a study of either class field theory (as formulated by Artin and Tate) or the contemporary treatment of analytical questions (as found, for example, in Tate's thesis).Although concerned exclusively with algebraic number fields, this treatment features axiomatic formulations with a considerable range of applications. Modem abstract te
Cohn, Harvey
1980-01-01
""A very stimulating book ... in a class by itself."" - American Mathematical MonthlyAdvanced students, mathematicians and number theorists will welcome this stimulating treatment of advanced number theory, which approaches the complex topic of algebraic number theory from a historical standpoint, taking pains to show the reader how concepts, definitions and theories have evolved during the last two centuries. Moreover, the book abounds with numerical examples and more concrete, specific theorems than are found in most contemporary treatments of the subject.The book is divided into three parts
Crossley, John N
1987-01-01
This book presents detailed studies of the development of three kinds of number. In the first part the development of the natural numbers from Stone-Age times right up to the present day is examined not only from the point of view of pure history but also taking into account archaeological, anthropological and linguistic evidence. The dramatic change caused by the introduction of logical theories of number in the 19th century is also treated and this part ends with a non-technical account of the very latest developments in the area of Gödel's theorem. The second part is concerned with the deve
Professor Stewart's incredible numbers
Stewart, Ian
2015-01-01
Ian Stewart explores the astonishing properties of numbers from 1 to10 to zero and infinity, including one figure that, if you wrote it out, would span the universe. He looks at every kind of number you can think of - real, imaginary, rational, irrational, positive and negative - along with several you might have thought you couldn't think of. He explains the insights of the ancient mathematicians, shows how numbers have evolved through the ages, and reveals the way numerical theory enables everyday life. Under Professor Stewart's guidance you will discover the mathematics of codes,
LeVeque, William J
1996-01-01
This excellent textbook introduces the basics of number theory, incorporating the language of abstract algebra. A knowledge of such algebraic concepts as group, ring, field, and domain is not assumed, however; all terms are defined and examples are given - making the book self-contained in this respect.The author begins with an introductory chapter on number theory and its early history. Subsequent chapters deal with unique factorization and the GCD, quadratic residues, number-theoretic functions and the distribution of primes, sums of squares, quadratic equations and quadratic fields, diopha
Kneusel, Ronald T
2015-01-01
This is a book about numbers and how those numbers are represented in and operated on by computers. It is crucial that developers understand this area because the numerical operations allowed by computers, and the limitations of those operations, especially in the area of floating point math, affect virtually everything people try to do with computers. This book aims to fill this gap by exploring, in sufficient but not overwhelming detail, just what it is that computers do with numbers. Divided into two parts, the first deals with standard representations of integers and floating point numb
Sierpinski, Waclaw
1988-01-01
Since the publication of the first edition of this work, considerable progress has been made in many of the questions examined. This edition has been updated and enlarged, and the bibliography has been revised.The variety of topics covered here includes divisibility, diophantine equations, prime numbers (especially Mersenne and Fermat primes), the basic arithmetic functions, congruences, the quadratic reciprocity law, expansion of real numbers into decimal fractions, decomposition of integers into sums of powers, some other problems of the additive theory of numbers and the theory of Gaussian
Directory of Open Access Journals (Sweden)
R. A. Mollin
1986-01-01
Full Text Available A powerful number is a positive integer n satisfying the property that p2 divides n whenever the prime p divides n; i.e., in the canonical prime decomposition of n, no prime appears with exponent 1. In [1], S.W. Golomb introduced and studied such numbers. In particular, he asked whether (25,27 is the only pair of consecutive odd powerful numbers. This question was settled in [2] by W.A. Sentance who gave necessary and sufficient conditions for the existence of such pairs. The first result of this paper is to provide a generalization of Sentance's result by giving necessary and sufficient conditions for the existence of pairs of powerful numbers spaced evenly apart. This result leads us naturally to consider integers which are representable as a proper difference of two powerful numbers, i.e. n=p1−p2 where p1 and p2 are powerful numbers with g.c.d. (p1,p2=1. Golomb (op.cit. conjectured that 6 is not a proper difference of two powerful numbers, and that there are infinitely many numbers which cannot be represented as a proper difference of two powerful numbers. The antithesis of this conjecture was proved by W.L. McDaniel [3] who verified that every non-zero integer is in fact a proper difference of two powerful numbers in infinitely many ways. McDaniel's proof is essentially an existence proof. The second result of this paper is a simpler proof of McDaniel's result as well as an effective algorithm (in the proof for explicitly determining infinitely many such representations. However, in both our proof and McDaniel's proof one of the powerful numbers is almost always a perfect square (namely one is always a perfect square when n≢2(mod4. We provide in §2 a proof that all even integers are representable in infinitely many ways as a proper nonsquare difference; i.e., proper difference of two powerful numbers neither of which is a perfect square. This, in conjunction with the odd case in [4], shows that every integer is representable in
Corry, Leo
2015-01-01
The world around us is saturated with numbers. They are a fundamental pillar of our modern society, and accepted and used with hardly a second thought. But how did this state of affairs come to be? In this book, Leo Corry tells the story behind the idea of number from the early days of the Pythagoreans, up until the turn of the twentieth century. He presents an overview of how numbers were handled and conceived in classical Greek mathematics, in the mathematics of Islam, in European mathematics of the middle ages and the Renaissance, during the scientific revolution, all the way through to the
Dudley, Underwood
2008-01-01
Ideal for a first course in number theory, this lively, engaging text requires only a familiarity with elementary algebra and the properties of real numbers. Author Underwood Dudley, who has written a series of popular mathematics books, maintains that the best way to learn mathematics is by solving problems. In keeping with this philosophy, the text includes nearly 1,000 exercises and problems-some computational and some classical, many original, and some with complete solutions. The opening chapters offer sound explanations of the basics of elementary number theory and develop the fundamenta
African Journals Online (AJOL)
OLUWOLE
with large succulent leaves while the male plants produce leaves that are scrawny, small and less attractive. Farmers therefore prefer the females to the males. Unfortunately, it is very difficult to differentiate the males from the females until the plants begin to flower. At this stage of development, the male plants begin to show.
African Journals Online (AJOL)
OLUWOLE
the villages by a variety of small scale methods into many different products that cater for the local preferences and for industrial use. The popular form in which cassava is eaten in West Africa is in a ... weighed using analytical weighing balance and added to 10 ml of sterile distilled water in a test tube. The content was then ...
Small Hydropower - The comeback of small hydropower stations
International Nuclear Information System (INIS)
Niederhaeusern, A.
2008-01-01
This issue of the 'Erneuerbare Energien' (renewable energies) magazine published by the Swiss Solar Energy Society takes a look at small hydropower projects in Switzerland. In a number of interviews and articles, various topics concerning small hydropower are dealt with. First of all, an interview with Bruno Guggisberg, previously responsible for small hydro at the Swiss Federal Office of Energy, examines the potential of small hydro and the various political, technical and economic influences on such projects. Further articles provide an overview of the various types of small hydro schemes, including power generation using height differences in drinking-water and wastewater installations. As far as the components of small hydro schemes are concerned, various types of turbines and further system components that are needed are examined. A further article takes a look at the small hydro market and the market players involved. Ecological aspects and research activities are discussed in further articles. In a second interview with Martin Boelli, presently responsible for small hydropower at the Swiss Federal Office of Energy, the unused potential for the use of hydropower in Switzerland is discussed. Examples of small-scale hydro schemes are examined and the support offered by the Small Hydropower Program is discussed. Finally the question is asked, if the small hydro market in Switzerland is overheated as a result of promotion schemes such as cost-covering remuneration for electricity from renewable energy sources.
African Journals Online (AJOL)
OLUWOLE
Agro-Science Journal of Tropical Agriculture, Food, Environment and Extension. Volume 9 Number 1 ... of persistent dumping of cheap subsidized food imports from developed ... independence of the inefficiency effects in the two estimation ...
High Reynolds Number Turbulence
National Research Council Canada - National Science Library
Smits, Alexander J
2007-01-01
The objectives of the grant were to provide a systematic study to fill the gap between existing research on low Reynolds number turbulent flows to the kinds of turbulent flows encountered on full-scale vehicles...
International Development Research Centre (IDRC) Digital Library (Canada)
Operating a Demographic Surveillance System (DSS) like this one requires a blend of high-tech number-crunching ability and .... views follow a standardized format that takes several ... general levels of health and to the use of health services.
Quantum random number generator
Pooser, Raphael C.
2016-05-10
A quantum random number generator (QRNG) and a photon generator for a QRNG are provided. The photon generator may be operated in a spontaneous mode below a lasing threshold to emit photons. Photons emitted from the photon generator may have at least one random characteristic, which may be monitored by the QRNG to generate a random number. In one embodiment, the photon generator may include a photon emitter and an amplifier coupled to the photon emitter. The amplifier may enable the photon generator to be used in the QRNG without introducing significant bias in the random number and may enable multiplexing of multiple random numbers. The amplifier may also desensitize the photon generator to fluctuations in power supplied thereto while operating in the spontaneous mode. In one embodiment, the photon emitter and amplifier may be a tapered diode amplifier.
Solar Indices - Sunspot Numbers
National Oceanic and Atmospheric Administration, Department of Commerce — Collection includes a variety of indices related to solar activity contributed by a number of national and private solar observatories located worldwide. This...
Interaction between numbers and size during visual search
Krause, Florian; Bekkering, Harold; Pratt, Jay; Lindemann, Oliver
2016-01-01
The current study investigates an interaction between numbers and physical size (i.e. size congruity) in visual search. In three experiments, participants had to detect a physically large (or small) target item among physically small (or large) distractors in a search task comprising single-digit numbers. The relative numerical size of the digits was varied, such that the target item was either among the numerically large or small numbers in the search display and the relation between numeric...
Indian Academy of Sciences (India)
One could endlessly churn out congruent numbers following the method in Box 1 without being certain when a given number n (or n x m 2, for some integer m) will ap- pear on the list. Continuing in this way ·would exhaust one's computing resources, not to mention one's patience! Also, this procedure is of no avail if n is not ...
DEFF Research Database (Denmark)
Korsby, Trine Mygind
2017-01-01
Taking a point of departure in negotiations for access to a phone number for a brothel abroad, the article demonstrates how a group of pimps in Eastern Romania attempt to extend their local business into the rest of the EU. The article shows how the phone number works as a micro-infrastructure in......Taking a point of departure in negotiations for access to a phone number for a brothel abroad, the article demonstrates how a group of pimps in Eastern Romania attempt to extend their local business into the rest of the EU. The article shows how the phone number works as a micro...... in turn cultivate and maximize uncertainty about themselves in others. When making the move to go abroad into unknown terrains, accessing the infrastructure generated by the phone number can provide certainty and consolidate one’s position within criminal networks abroad. However, at the same time......, mishandling the phone number can be dangerous and in that sense produce new doubts and uncertainties....
Energy Technology Data Exchange (ETDEWEB)
Nelson, R.N. (ed.)
1985-05-01
This publication lists all report number codes processed by the Office of Scientific and Technical Information. The report codes are substantially based on the American National Standards Institute, Standard Technical Report Number (STRN)-Format and Creation Z39.23-1983. The Standard Technical Report Number (STRN) provides one of the primary methods of identifying a specific technical report. The STRN consists of two parts: The report code and the sequential number. The report code identifies the issuing organization, a specific program, or a type of document. The sequential number, which is assigned in sequence by each report issuing entity, is not included in this publication. Part I of this compilation is alphabetized by report codes followed by issuing installations. Part II lists the issuing organization followed by the assigned report code(s). In both Parts I and II, the names of issuing organizations appear for the most part in the form used at the time the reports were issued. However, for some of the more prolific installations which have had name changes, all entries have been merged under the current name.
International Nuclear Information System (INIS)
Nelson, R.N.
1985-05-01
This publication lists all report number codes processed by the Office of Scientific and Technical Information. The report codes are substantially based on the American National Standards Institute, Standard Technical Report Number (STRN)-Format and Creation Z39.23-1983. The Standard Technical Report Number (STRN) provides one of the primary methods of identifying a specific technical report. The STRN consists of two parts: The report code and the sequential number. The report code identifies the issuing organization, a specific program, or a type of document. The sequential number, which is assigned in sequence by each report issuing entity, is not included in this publication. Part I of this compilation is alphabetized by report codes followed by issuing installations. Part II lists the issuing organization followed by the assigned report code(s). In both Parts I and II, the names of issuing organizations appear for the most part in the form used at the time the reports were issued. However, for some of the more prolific installations which have had name changes, all entries have been merged under the current name
Gerlovina, Inna; van der Laan, Mark J; Hubbard, Alan
2017-05-20
Multiple comparisons and small sample size, common characteristics of many types of "Big Data" including those that are produced by genomic studies, present specific challenges that affect reliability of inference. Use of multiple testing procedures necessitates calculation of very small tail probabilities of a test statistic distribution. Results based on large deviation theory provide a formal condition that is necessary to guarantee error rate control given practical sample sizes, linking the number of tests and the sample size; this condition, however, is rarely satisfied. Using methods that are based on Edgeworth expansions (relying especially on the work of Peter Hall), we explore the impact of departures of sampling distributions from typical assumptions on actual error rates. Our investigation illustrates how far the actual error rates can be from the declared nominal levels, suggesting potentially wide-spread problems with error rate control, specifically excessive false positives. This is an important factor that contributes to "reproducibility crisis". We also review some other commonly used methods (such as permutation and methods based on finite sampling inequalities) in their application to multiple testing/small sample data. We point out that Edgeworth expansions, providing higher order approximations to the sampling distribution, offer a promising direction for data analysis that could improve reliability of studies relying on large numbers of comparisons with modest sample sizes.
DEFF Research Database (Denmark)
Levin, Bruce R; McCall, Ingrid C.; Perrot, Veronique
2017-01-01
We postulate that the inhibition of growth and low rates of mortality of bacteria exposed to ribosome-binding antibiotics deemed bacteriostatic can be attributed almost uniquely to these drugs reducing the number of ribosomes contributing to protein synthesis, i.e., the number of effective......-targeting bacteriostatic antibiotics, the time before these bacteria start to grow again when the drugs are removed, referred to as the post-antibiotic effect (PAE), is markedly greater for constructs with fewer rrn operons than for those with more rrn operons. We interpret the results of these other experiments reported...... here as support for the hypothesis that the reduction in the effective number of ribosomes due to binding to these structures provides a sufficient explanation for the action of bacteriostatic antibiotics that target these structures....
Quantum random number generator
Soubusta, Jan; Haderka, Ondrej; Hendrych, Martin
2001-03-01
Since reflection or transmission of a quantum particle on a beamsplitter is inherently random quantum process, a device built on this principle does not suffer from drawbacks of neither pseudo-random computer generators or classical noise sources. Nevertheless, a number of physical conditions necessary for high quality random numbers generation must be satisfied. Luckily, in quantum optics realization they can be well controlled. We present an easy random number generator based on the division of weak light pulses on a beamsplitter. The randomness of the generated bit stream is supported by passing the data through series of 15 statistical test. The device generates at a rate of 109.7 kbit/s.
Alizée Dauvergne
2010-01-01
What makes the LHC the biggest particle accelerator in the world? Here are some of the numbers that characterise the LHC, and their equivalents in terms that are easier for us to imagine. Feature Number Equivalent Circumference ~ 27 km Distance covered by beam in 10 hours ~ 10 billion km a round trip to Neptune Number of times a single proton travels around the ring each second 11 245 Speed of protons first entering the LHC 299 732 500 m/s 99.9998 % of the speed of light Speed of protons when they collide 299 789 760 m/s 99.9999991 % of the speed of light Collision temperature ~ 1016 °C ove...
Samuel, Pierre
2008-01-01
Algebraic number theory introduces students not only to new algebraic notions but also to related concepts: groups, rings, fields, ideals, quotient rings and quotient fields, homomorphisms and isomorphisms, modules, and vector spaces. Author Pierre Samuel notes that students benefit from their studies of algebraic number theory by encountering many concepts fundamental to other branches of mathematics - algebraic geometry, in particular.This book assumes a knowledge of basic algebra but supplements its teachings with brief, clear explanations of integrality, algebraic extensions of fields, Gal
Iwaniec, Henryk
2004-01-01
Analytic Number Theory distinguishes itself by the variety of tools it uses to establish results, many of which belong to the mainstream of arithmetic. One of the main attractions of analytic number theory is the vast diversity of concepts and methods it includes. The main goal of the book is to show the scope of the theory, both in classical and modern directions, and to exhibit its wealth and prospects, its beautiful theorems and powerful techniques. The book is written with graduate students in mind, and the authors tried to balance between clarity, completeness, and generality. The exercis
CONFUSION WITH TELEPHONE NUMBERS
Telecom Service
2002-01-01
he area code is now required for all telephone calls within Switzerland. Unfortunately this is causing some confusion. CERN has received complaints that incoming calls intended for CERN mobile phones are being directed to private subscribers. This is caused by mistakenly dialing the WRONG code (e.g. 022) in front of the mobile number. In order to avoid these problems, please inform your correspondents that the correct numbers are: 079 201 XXXX from Switzerland; 0041 79 201 XXXX from other countries. Telecom Service
CONFUSION WITH TELEPHONE NUMBERS
Telecom Service
2002-01-01
The area code is now required for all telephone calls within Switzerland. Unfortunately this is causing some confusion. CERN has received complaints that incoming calls intended for CERN mobile phones are being directed to private subscribers. This is caused by mistakenly dialing the WRONG code (e.g. 022) in front of the mobile number. In order to avoid these problems, please inform your correspondents that the correct numbers are: 079 201 XXXX from Switzerland; 0041 79 201 XXXX from other countries. Telecom Service
Wetherell, Chris
2017-01-01
This is an edited extract from the keynote address given by Dr. Chris Wetherell at the 26th Biennial Conference of the Australian Association of Mathematics Teachers Inc. The author investigates the surprisingly rich structure that exists within a simple arrangement of numbers: the times tables.
Bell, Eric Temple
1991-01-01
From one of the foremost interpreters for lay readers of the history and meaning of mathematics: a stimulating account of the origins of mathematical thought and the development of numerical theory. It probes the work of Pythagoras, Galileo, Berkeley, Einstein, and others, exploring how ""number magic"" has influenced religion, philosophy, science, and mathematics
International Nuclear Information System (INIS)
Khan, T.A.; Baum, J.W.; Beckman, M.C.
1993-10-01
This document contains information dealing with the lessons learned from the experience of nuclear plants. In this issue the authors tried to avoid the 'tyranny' of numbers and concentrated on the main lessons learned. Topics include: filtration devices for air pollution abatement, crack repair and inspection, and remote handling equipment
Uniform random number generators
Farr, W. R.
1971-01-01
Methods are presented for the generation of random numbers with uniform and normal distributions. Subprogram listings of Fortran generators for the Univac 1108, SDS 930, and CDC 3200 digital computers are also included. The generators are of the mixed multiplicative type, and the mathematical method employed is that of Marsaglia and Bray.
International Nuclear Information System (INIS)
1994-01-01
The key numbers of energy give statistical data related to production, consumption, and to foreign trade of each energy in the World and in France. A chapter is dedicated to environment and brings quantitative elements on pollutant emissions connected to energy uses
Directory of Open Access Journals (Sweden)
Oli Brown
2008-10-01
Full Text Available Estimates of the potential number of ‘climate changemigrants’ vary hugely. In order to persuade policymakers ofthe need to act and to provide a sound basis for appropriateresponses, there is an urgent need for better analysis, betterdata and better predictions.
Trudgian, Timothy
2009-01-01
One of the difficulties in any teaching of mathematics is to bridge the divide between the abstract and the intuitive. Throughout school one encounters increasingly abstract notions, which are more and more difficult to relate to everyday experiences. This article examines a familiar approach to thinking about negative numbers, that is an…
Indian Academy of Sciences (India)
First page Back Continue Last page Overview Graphics. Typical Complexity Numbers. Say. 1000 tones,; 100 Users,; Transmission every 10 msec. Full Crosstalk cancellation would require. Full cancellation requires a matrix multiplication of order 100*100 for all the tones. 1000*100*100*100 operations every second for the ...
Indian Academy of Sciences (India)
IAS Admin
improved by Selberg [4] in 1941 who showed that a pos- ... be seen by entries of his first letter to G H Hardy in ... tary in the technical sense of the word, employed com- ..... III: On the expression of a number as a sum of primes, Acta Math.,.
International Nuclear Information System (INIS)
Wicke, Peter
1998-01-01
The government in Peru has decided to utilise its gas reserves and restrict hydro to relatively small schemes. A number of reasons for the decision are given. In 1997, the Shell-Mobile-Bechtel-COSAPI consortium was formed and agreements were signed regarding exploiting Gas de Camisea. The country's energy needs to 2010 are being assessed. It is likely that by 2001 the whole of south Peru will be receiving gas from Camisea. The Peru situation is discussed under the headings of (i) existing capacity, (ii) growing demands, (iii) a history of hydro in Peru, (iv) electrification and SHP and (v) outlook. The future for Peru's electric energy development is bright. While most of its new power capacity will come from natural gas, the small hydros also have a part to play. A stronger commitment of national and regional political authorities to consider supplies outside the big cities is said to be needed. (UK)
The Body of Hurt in Margaret Atwood's Novel Bodily Harm
Directory of Open Access Journals (Sweden)
Avital Gad Cykman
2015-01-01
This article analyses Margaret Atwood’s novel BODILY HARM (1981 in regard to its exploration of the link between corporeality and contextuality, focusing on the relation between the historical and socio-cultural context in which identity is constructed and the female character’s perception of body and self. The character’s retrospective journey serves as a ground for a deconstruction of the character’s values, behavior, relationships, and discomfort with the body in order to reveal the power relations and social causes behind her present situation. The study focuses on the literary articulation of the problems of being female, the exploration of the relation between the biological body and the cultural concept of the body, and the criticism of social representations of women.
International Nuclear Information System (INIS)
Metcalfe, N.; Shanks, T.; Fong, R.; Jones, L.R.
1991-01-01
Using the Prime Focus CCD Camera at the Isaac Newton Telescope we have determined the form of the B and R galaxy number-magnitude count relations in 12 independent fields for 21 m ccd m and 19 m ccd m 5. The average galaxy count relations lie in the middle of the wide range previously encompassed by photographic data. The field-to-field variation of the counts is small enough to define the faint (B m 5) galaxy count to ±10 per cent and this variation is consistent with that expected from galaxy clustering considerations. Our new data confirm that the B, and also the R, galaxy counts show evidence for strong galaxy luminosity evolution, and that the majority of the evolving galaxies are of moderately blue colour. (author)
1985-02-01
of the blade. The Darrieus VAWT has more complex aerodynamics. This type of wind turbine produces power as a result of the tangential thrust as...Horizontal Axis Propeller-Type b) Verticle Axis Darrieus -Type Figure 78. Wind Turbine Configurations 0 6 Q K [_ 2 -, C 4 UJ UJ...Sailplanes 23 5.2 Wind Turbines 23 6. CONCLUDING REMARKS 24 7. RECOMMENDATIONS FOR FUTURE RESEARCH 24 REFERENCES 25 FIGURES 32 yv/ LOW REYNOLDS NUMBER
Cortical areas involved in Arabic number reading.
Roux, F-E; Lubrano, V; Lauwers-Cances, V; Giussani, C; Démonet, J-F
2008-01-15
Distinct functional pathways for processing words and numbers have been hypothesized from the observation of dissociated impairments of these categories in brain-damaged patients. We aimed to identify the cortical areas involved in Arabic number reading process in patients operated on for various brain lesions. Direct cortical electrostimulation was prospectively used in 60 brain mappings. We used object naming and two reading tasks: alphabetic script (sentences and number words) and Arabic number reading. Cortical areas involved in Arabic number reading were identified according to location, type of interference, and distinctness from areas associated with other language tasks. Arabic number reading was sustained by small cortical areas, often extremely well localized (area (Brodmann area 45), the anterior part of the dominant supramarginal gyrus (Brodmann area 40; p area (Brodmann area 37; p areas.
Stellarator fields with small PS current at small rotational transform
International Nuclear Information System (INIS)
Herrnegger, F.
2001-01-01
One aspect of the optimization concept of stellarators is the reduction of the normalized Pfirsch-Schlueter current density p arallel 2 / j p erpendikular 2 > 1/2 to a reasonable level but obeying other side conditions, e.g., concerning small bootstrap currents, good stability properties, reasonable aspect ratio, etc. This problem is addressed in the present work. Various stellarator vacuum field are given analytically for M 2, 3, 5, 10, 12 (M is the number of field period around the torus) where the PS-current density is reduced by more than a factor of ten to rather small values around 0.3 even at small i-values
DEFF Research Database (Denmark)
Simonsen, Karina T; Gallego, Sandra F; Færgeman, Nils J.
2012-01-01
alterations on the transcriptional and translational levels. Early on, researchers took advantage of the possibility to conduct large-scale investigations of the C. elegans immune response. Multiple studies demonstrated that C. elegans does indeed mount a protective response against invading pathogens, thus...... rendering this small nematode a very useful and simple host model for the study of innate immunity and host-pathogen interactions. Here, we provide an overview of key aspects of innate immunity in C. elegans revealed by recent whole-genome transcriptomics and proteomics studies of the global response of C......For more than ten years the nematode Caenorhabditis elegans has proven to be a valuable model for studies of the host response to various bacterial and fungal pathogens. When exposed to a pathogenic organism, a clear response is elicited in the nematode, which is characterized by specific...
Small Business Development Center
Small Business Administration — Small Business Development Centers (SBDCs) provide assistance to small businesses and aspiring entrepreneurs throughout the United States and its territories. SBDCs...
LeVeque, William J
2002-01-01
Classic two-part work now available in a single volume assumes no prior theoretical knowledge on reader's part and develops the subject fully. Volume I is a suitable first course text for advanced undergraduate and beginning graduate students. Volume II requires a much higher level of mathematical maturity, including a working knowledge of the theory of analytic functions. Contents range from chapters on binary quadratic forms to the Thue-Siegel-Roth Theorem and the Prime Number Theorem. Includes numerous problems and hints for their solutions. 1956 edition. Supplementary Reading. List of Symb
DEFF Research Database (Denmark)
Wanscher, Jørgen Bundgaard; Sørensen, Majken Vildrik
2006-01-01
Random numbers are used for a great variety of applications in almost any field of computer and economic sciences today. Examples ranges from stock market forecasting in economics, through stochastic traffic modelling in operations research to photon and ray tracing in graphics. The construction...... distributions into others with most of the required characteristics. In essence, a uniform sequence which is transformed into a new sequence with the required distribution. The subject of this article is to consider the well known highly uniform Halton sequence and modifications to it. The intent is to generate...
Interaction of Number Magnitude and Auditory Localization.
Golob, Edward J; Lewald, Jörg; Jungilligens, Johannes; Getzmann, Stephan
2016-01-01
The interplay of perception and memory is very evident when we perceive and then recognize familiar stimuli. Conversely, information in long-term memory may also influence how a stimulus is perceived. Prior work on number cognition in the visual modality has shown that in Western number systems long-term memory for the magnitude of smaller numbers can influence performance involving the left side of space, while larger numbers have an influence toward the right. Here, we investigated in the auditory modality whether a related effect may bias the perception of sound location. Subjects (n = 28) used a swivel pointer to localize noise bursts presented from various azimuth positions. The noise bursts were preceded by a spoken number (1-9) or, as a nonsemantic control condition, numbers that were played in reverse. The relative constant error in noise localization (forward minus reversed speech) indicated a systematic shift in localization toward more central locations when the number was smaller and toward more peripheral positions when the preceding number magnitude was larger. These findings do not support the traditional left-right number mapping. Instead, the results may reflect an overlap between codes for number magnitude and codes for sound location as implemented by two channel models of sound localization, or possibly a categorical mapping stage of small versus large magnitudes. © The Author(s) 2015.
Relativistic theory of surficial Love numbers
Landry, Philippe; Poisson, Eric
2014-06-01
A relativistic theory of surficial Love numbers, which characterize the surface deformation of a body subjected to tidal forces, was initiated by Damour and Nagar. We revisit this effort in order to extend it, clarify some of its aspects, and simplify its computational implementation. First, we refine the definition of surficial Love numbers proposed by Damour and Nagar and formulate it directly in terms of the deformed curvature of the body's surface, a meaningful geometrical quantity. Second, we develop a unified theory of surficial Love numbers that applies equally well to material bodies and black holes. Third, we derive a compactness-dependent relation between the surficial and (electric-type) gravitational Love numbers of a perfect-fluid body and show that it reduces to the familiar Newtonian relation when the compactness is small. And fourth, we simplify the tasks associated with the practical computation of the surficial and gravitational Love numbers for a material body.
Directory of Open Access Journals (Sweden)
ABR Thomson
1996-01-01
Full Text Available Major scientific advances have been made over the past few years in the areas of small bowel physiology, pathology, microbiology and clinical sciences. Over 1000 papers have been reviewed and a selective number are considered here. Wherever possible, the clinical relevance of these advances have been identified. There have been a number of important and/or interesting developments in the past year that have clinical significance.
Random numbers spring from alpha decay
International Nuclear Information System (INIS)
Frigerio, N.A.; Sanathanan, L.P.; Morley, M.; Clark, N.A.; Tyler, S.A.
1980-05-01
Congruential random number generators, which are widely used in Monte Carlo simulations, are deficient in that the number they generate are concentrated in a relatively small number of hyperplanes. While this deficiency may not be a limitation in small Monte Carlo studies involving a few variables, it introduces a significant bias in large simulations requiring high resolution. This bias was recognized and assessed during preparations for an accident analysis study of nuclear power plants. This report describes a random number device based on the radioactive decay of alpha particles from a 235 U source in a high-resolution gas proportional counter. The signals were fed to a 4096-channel analyzer and for each channel the frequency of signals registered in a 20,000-microsecond interval was recorded. The parity bits of these frequency counts (0 for an even count and 1 for an odd count) were then assembled in sequence to form 31-bit binary random numbers and transcribed to a magnetic tape. This cycle was repeated as many times as were necessary to create 3 million random numbers. The frequency distribution of counts from the present device conforms to the Brockwell-Moyal distribution, which takes into account the dead time of the counter (both the dead time and decay constant of the underlying Poisson process were estimated). Analysis of the count data and tests of randomness on a sample set of the 31-bit binary numbers indicate that this random number device is a highly reliable source of truly random numbers. Its use is, therefore, recommended in Monte Carlo simulations for which the congruential pseudorandom number generators are found to be inadequate. 6 figures, 5 tables
Direct Numerical Simulations of Rayleigh-Taylor instability
International Nuclear Information System (INIS)
Livescu, D; Wei, T; Petersen, M R
2011-01-01
The development of the Rayleigh-Taylor mixing layer is studied using data from an extensive new set of Direct Numerical Simulations (DNS), performed on the 0.5 Petaflops, 150k compute cores BG/L Dawn supercomputer at Lawrence Livermore National Laboratory. This includes a suite of simulations with grid size of 1024 2 × 4608 and Atwood number ranging from 0.04 to 0.9, in order to examine small departures from the Boussinesq approximation as well as large Atwood number effects, and a high resolution simulation of grid size 4096 2 × 4032 and Atwood number of 0.75. After the layer width had developed substantially, additional branched simulations have been run under reversed and zero gravity conditions. While the bulk of the results will be published elsewhere, here we present preliminary results on: 1) the long-standing open question regarding the discrepancy between the numerically and experimentally measured mixing layer growth rates and 2) mixing characteristics.
van Gijn, J
2000-01-01
The round figure for the current year has stirred people's minds in anticipation. Numbers have acquired great significance also in today's medical science. The Paris physician Pierre Charles Alexandre Louis (1787-1872) is considered the founding father of the numerical method in medicine. At first the principle of aggregating data from different individuals aroused much resistance and even disgust: Claude Bernard was a leading figure among those who warned that one will never find a mean in nature, and that grouping findings together obscures the true relationship between biological phenomena. True enough, statistical significance is not a characteristic of nature itself. Significant differences or risk reductions do not necessarily imply clinical relevance, and results obtained in a group of patients are rarely applicable to an individual patient in the consultation room. Likewise, the health of a human being cannot be captured in biochemical, radiological or other technical measures, nor in disease-specific scales that reduce well-being to one or two digits. The editors of this journal will remain keen on publishing numerical studies that contribute to evidence-based medicine, but at the same time they will continue to foster the art of reporting illness from the point of view of the sick person.
Straight flavor of Binary Number in Decimal Number System
MD. Abdul Awal Ansary; Sushanta Acharjee
2012-01-01
Different number systems are available on the basis of their base numbers. For instance, decimal number system is of base 10, hexadecimal number system which base is 16 and, Binary number system which base is 2 etc. Some numbers systems are easy to understand by the human being and some are easy to understand by electronics machine for instance digital computers. Computers only can understand data and instructions that are stored in binary form, though we input the data and instruction in dec...
Directory of Open Access Journals (Sweden)
Christian Agrillo
Full Text Available BACKGROUND: Research on human infants, mammals, birds and fish has demonstrated that rudimentary numerical abilities pre-date the evolution of human language. Yet there is controversy as to whether animals represent numbers mentally or rather base their judgments on non-numerical perceptual variables that co-vary with numerosity. To date, mental representation of number has been convincingly documented only for a few mammals. METHODOLOGY/PRINCIPAL FINDINGS: Here we used a training procedure to investigate whether mosquitofish could learn to discriminate between two and three objects even when denied access to non-numerical information. In the first experiment, fish were trained to discriminate between two sets of geometric figures. These varied in shape, size, brightness and distance, but no control for non-numerical variables was made. Subjects were then re-tested while controlling for one non-numerical variable at a time. Total luminance of the stimuli and the sum of perimeter of figures appeared irrelevant, but performance dropped to chance level when stimuli were matched for the cumulative surface area or for the overall space occupied by the arrays, indicating that these latter cues had been spontaneously used by the fish during the learning process. In a second experiment, where the task consisted of discriminating 2 vs 3 elements with all non-numerical variables simultaneously controlled for, all subjects proved able to learn the discrimination, and interestingly they did not make more errors than the fish in Experiment 1 that could access non-numerical information in order to accomplish the task. CONCLUSIONS/SIGNIFICANCE: Mosquitofish can learn to discriminate small quantities, even when non-numerical indicators of quantity are unavailable, hence providing the first evidence that fish, like primates, can use numbers. As in humans and non-human primates, genuine counting appears to be a 'last resort' strategy in fish, when no other
Number Line Estimation in Children with Developmental Dyscalculia
Sella, Francesco; Berteletti, Ilaria; Martina, Brazzolotto; Lucangeli, Daniela; Zorzi, Marco
2013-01-01
In the number to position task, several studies have shown that typically developing children shift from a biased (logarithmic) to an accurate (linear) mapping of symbolic digits onto a spatial position on a line. The initial pattern of overestimation of small numbers and the underestimation of larger numbers is compensated by means of age and…
Some Remarks on Iterated Maps of Natural Numbers
Indian Academy of Sciences (India)
IAS Admin
happy numbers, Fibonacci Quart., Vol.41, 2003, No.4, pp.301–306,. 2003. [7]. H G Grundman and E A Teeple, Sequences of generalized happy numbers with small bases, J. Integer Seq., Vol.10, No.1, Article 07.1.8,. 6, 2007. [8]. H G Grundman and E A Teeple, Sequences of consecutive happy numbers, Rocky Mountain J.
Business Opportunities for Small Reactors
International Nuclear Information System (INIS)
Minato, Akio; Nishimura, Satoshi; Brown, Neil W.
2007-01-01
This report assesses the market potential and identifies a number of potential paths for developing the small nuclear reactor business. There are several potential opportunities identified and evaluated. Selecting a specific approach for the business development requires additional information related to a specific market and sources of capital to support the investment. If and how a market for small nuclear plants may develop is difficult to predict because of the complexity of the economic and institutional factors that will influence such development. Key factors are; economics, safety, proliferation resistance and investment risk. The economic and political interest of any of the identified markets is also dependent on successful demonstration of the safety and reliability of small nuclear reactor. Obtaining a US-NRC Standard Design approval would be an important development step toward establishing a market for small reactors. (authors)
Cancer - lung - small cell; Small cell lung cancer; SCLC ... About 15% of all lung cancer cases are SCLC. Small cell lung cancer is slightly more common in men than women. Almost all cases of SCLC are ...
International Development Research Centre (IDRC) Digital Library (Canada)
consumption of small millets, mainly due to limited productivity, high ... for effective integration of small millets in the ... replicated in other cities. ... to micro-, small- and medium-entrepreneurs producing millet-based ... and Activities Network,.
Catalin Mihail BARBU; Radu Florin OGARCA; Mihai Razvan Constantin BARBU
2010-01-01
In this paper we analyzed the branding in small business. Using a desk research on Internet and the press we have identified the practices small businesses use to enhance their brand and the brand dynamics in small business. Our main contribution is that we tried to figure out the strategy of branding in small business. This need further to be investigated in order to understand how branding works in small business and to better capture the role of branding in small business.
Small Business Management. Getting a Small Business Management Education Program Started.
Minnesota Univ., St. Paul. Dept. of Agricultural Education.
This set of materials was developed to assist with the dissemination of the Minnesota model for small business management education, five sections of information are presented. The first of five sections is on small business management needs assessment and describes a method of determining the number of small businesses that would constitute a…
Small Business Administration — Certain government programs, such as SBA loan programs and contracting opportunities, are reserved for small business concerns. In order to qualify, businesses must...
[Intel random number generator-based true random number generator].
Huang, Feng; Shen, Hong
2004-09-01
To establish a true random number generator on the basis of certain Intel chips. The random numbers were acquired by programming using Microsoft Visual C++ 6.0 via register reading from the random number generator (RNG) unit of an Intel 815 chipset-based computer with Intel Security Driver (ISD). We tested the generator with 500 random numbers in NIST FIPS 140-1 and X(2) R-Squared test, and the result showed that the random number it generated satisfied the demand of independence and uniform distribution. We also compared the random numbers generated by Intel RNG-based true random number generator and those from the random number table statistically, by using the same amount of 7500 random numbers in the same value domain, which showed that the SD, SE and CV of Intel RNG-based random number generator were less than those of the random number table. The result of u test of two CVs revealed no significant difference between the two methods. Intel RNG-based random number generator can produce high-quality random numbers with good independence and uniform distribution, and solves some problems with random number table in acquisition of the random numbers.
Mastering Microsoft Windows Small Business Server 2008
Johnson, Steven
2010-01-01
A complete, winning approach to the number one small business solution. Do you have 75 or fewer users or devices on your small-business network? Find out how to integrate everything you need for your mini-enterprise with Microsoft's new Windows Server 2008 Small Business Server, a custom collection of server and management technologies designed to help small operations run smoothly without a giant IT department. This comprehensive guide shows you how to master all SBS components as well as handle integration with other Microsoft technologies.: Focuses on Windows Server 2008 Small Business Serv
Small silencing RNAs: an expanding universe.
Ghildiyal, Megha; Zamore, Phillip D
2009-02-01
Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). These classes differ in their biogenesis, their modes of target regulation and in the biological pathways they regulate. There is a growing realization that, despite their differences, these distinct small RNA pathways are interconnected, and that small RNA pathways compete and collaborate as they regulate genes and protect the genome from external and internal threats.
Purchasing cooperatives for small employers.
Mallozzi, J
1997-12-01
Despite a booming economy, the number of uninsured Americans is rising. It hit nearly 42 million in 1996. Many of the uninsured work at businesses with fewer than 50 employees. Because small firms have traditionally found it difficult to provide health benefits, purchasing cooperatives have grown in scope and size across the country in recent years. By bringing small businesses together to buy insurance as a group, these organizations can help employers provide greater choice to their workers at a lower cost. However, to operate well in the insurance market, purchasing cooperatives must be well-designed and provided with adequate legal protections.
Small Wind Turbine Technology Assessment
International Nuclear Information System (INIS)
Avia Aranda, F.; Cruz Cruz, I.
1999-01-01
The result of the study carried out under the scope of the ATYCA project Test Plant of Wind Systems for Isolated Applications, about the state of art of the small wind turbine technology (wind turbines with swept area smaller than 40 m 2 ) is presented. The study analyzes the collected information on 60 models of wind turbines from 23 manufacturers in the worldwide market. Data from Chinese manufacturers, that have a large participation in the total number of small wind turbines in operation, are not included, due to the unavailability of the technical information. (Author) 15 refs
Small Proteins Can No Longer Be Ignored
Storz, Gisela; Wolf, Yuri I.; Ramamurthi, Kumaran S.
2014-01-01
Small proteins, here defined as proteins of 50 amino acids or less in the absence of processing, have traditionally been overlooked due to challenges in their annotation and biochemical detection. In the past several years however, increasing numbers of small proteins have been identified either through the realization that mutations in “intergenic” regions actually are within unannotated small protein genes, or through the discovery that some small, regulatory RNAs (sRNAs) encode small proteins. These insights together with comparative sequence analysis indicate that tens if not hundreds of small proteins are synthesized in a given organism. This review will summarize what has been learned about the functions of several of these bacterial small proteins, most of which act at the membrane, illustrating the astonishing range of processes in which the small proteins act and pointing to several general conclusions. Important questions for future studies of these overlooked proteins also will be discussed. PMID:24606146
Bell numbers, determinants and series
Indian Academy of Sciences (India)
In this article, we study Bell numbers and Uppuluri Carpenter numbers. We obtain various expressions and relations between them. These include polynomial recurrences and expressions as determinants of certain matrices of binomial coefficients. Keywords. p-adic series; Bell numbers. 1. Introduction. Bell numbers, Bn [2] ...
Cosmic numbers the numbers that define our universe
Stein, James D
2011-01-01
Our fascination with numbers begins when we are children and continues throughout our lives. We start counting our fingers and toes and end up balancing checkbooks and calculating risk. So powerful is the appeal of numbers that many people ascribe to them a mystical significance. Other numbers go beyond the supernatural, working to explain our universe and how it behaves. In Cosmic Numbers , mathematics professor James D. Stein traces the discovery, evolution, and interrelationships of the numbers that define our world. Everyone knows about the speed of light and absolute zero, but numbers lik
Fermion number in supersymmetric models
International Nuclear Information System (INIS)
Mainland, G.B.; Tanaka, K.
1975-01-01
The two known methods for introducing a conserved fermion number into supersymmetric models are discussed. While the introduction of a conserved fermion number often requires that the Lagrangian be massless or that bosons carry fermion number, a model is discussed in which masses can be introduced via spontaneous symmetry breaking and fermion number is conserved at all stages without assigning fermion number to bosons. (U.S.)
The Influence of Investor Number on a Microscopic Market Model
Hellthaler, T.
The stock market model of Levy, Persky, Solomon is simulated for much larger numbers of investors. While small markets can lead to realistically looking prices, the resulting prices of large markets oscillate smoothly in a semi-regular fashion.
Directory of Open Access Journals (Sweden)
Konstantinos ePriftis
2012-02-01
Full Text Available Behavioral, neuropsychological, and neuroimaging data support the idea that numbers are represented along a mental number line (MNL, an analogical, visuo-spatial representation of number magnitude. The MNL is left-to-right oriented, with small numbers on the left and larger numbers on the right. Left neglect patients are impaired in processing the left side of the MNL and show a rightward deviation in the mental bisection of numerical intervals. In the present study we investigated the effects of optokinetic stimulation (OKS -a technique inducing spatial attention shifts by means of activation of the optokinetic nystagmus- on mental number interval bisection. One patient with left neglect following right hemisphere stroke (BG and four control patients with right hemisphere damage, but without neglect, performed the mental number interval bisection task in three experimental conditions of OKS: static, leftward, and rightward. In the static condition, BG misbisected to the right of the true midpoint. BG misbisected to the left following leftward OKS, but again to the right of the midpoint following rightward OKS. In contrast, the performance of controls was not significantly affected by the direction of OKS. We argue that shifts of visuospatial attention, induced by OKS, may affect the mental number interval bisection, suggesting the presence of an interaction between the processing of number magnitude and the processing of the perceptual space, in patients with neglect for the mental number space.
Priftis, Konstantinos; Pitteri, Marco; Meneghello, Francesca; Umiltà, Carlo; Zorzi, Marco
2012-01-01
Behavioral, neuropsychological, and neuroimaging data support the idea that numbers are represented along a mental number line (MNL), an analogical, visuospatial representation of number magnitude. The MNL is left-to-right oriented in Western cultures, with small numbers on the left and larger numbers on the right. Left neglect patients are impaired in the mental bisection of numerical intervals, with a bias toward larger numbers that are relatively to the right on the MNL. In the present study we investigated the effects of optokinetic stimulation (OKS) – a technique inducing visuospatial attention shifts by means of activation of the optokinetic nystagmus – on number interval bisection. One patient with left neglect following right-hemisphere stroke (BG) and four control patients with right-hemisphere damage, but without neglect, performed the number interval bisection task in three conditions of OKS: static, leftward, and rightward. In the static condition, BG misbisected to the right of the true midpoint. BG misbisected to the left following leftward OKS, and again to the right of the midpoint following rightward OKS. Moreover, the variability of BG’s performance was smaller following both leftward and rightward OKS, suggesting that the attentional bias induced by OKS reduced the “indifference zone” that is thought to underlie the length effect reported in bisection tasks. We argue that shifts of visuospatial attention, induced by OKS, may affect number interval bisection, thereby revealing an interaction between the processing of the perceptual space and the processing of the number space. PMID:22363280
The Mental Number Line in Dyscalculia: Impaired Number Sense or Access from Symbolic Numbers?
Lafay, Anne; St-Pierre, Marie-Catherine; Macoir, Joël
2017-01-01
Numbers may be manipulated and represented mentally over a compressible number line oriented from left to right. According to numerous studies, one of the primary reasons for dyscalculia is related to improper understanding of the mental number line. Children with dyscalculia usually show difficulty when they have to place Arabic numbers on a…
77 FR 28419 - Hawaii Disaster Number HI-00026
2012-05-14
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13065 and 13066] Hawaii Disaster Number HI-00026 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Hawaii...
75 FR 32821 - Minnesota Disaster Number MN-00024
2010-06-09
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12132 and 12133] Minnesota Disaster Number MN-00024 AGENCY: Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Minnesota (FEMA-1900...
75 FR 39059 - Minnesota Disaster Number MN-00024
2010-07-07
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12132 and 12133] Minnesota Disaster Number MN-00024 AGENCY: U.S. Small Business Administration. ACTION: Amendment 4. SUMMARY: This is an amendment of... (FEMA-1900-DR), dated 04/19/2010. Incident: Flooding. Incident Period: 03/01/2010 through 04/26/2010...
75 FR 26814 - Minnesota Disaster Number MN-00024
2010-05-12
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12132 and 12133] Minnesota Disaster Number MN-00024 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of... (FEMA-1900-DR), dated 04/19/2010. Incident: Flooding. Incident Period: 03/01/2010 and continuing...
75 FR 29590 - Minnesota Disaster Number MN-00024
2010-05-26
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12132 and 12133] Minnesota Disaster Number MN-00024 AGENCY: Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Minnesota (FEMA-1900...
75 FR 65390 - Iowa Disaster Number IA-00024
2010-10-22
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12279 and 12280] Iowa Disaster Number IA-00024 AGENCY: U.S. Small Business Administration. ACTION: Amendment 5. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Iowa (FEMA--1930--DR), dated 08/14/ 2010...
75 FR 51506 - Iowa Disaster Number IA-00026
2010-08-20
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12258 and 12259] Iowa Disaster Number IA-00026 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA- 1930-DR...
75 FR 62897 - Iowa Disaster Number IA-00024
2010-10-13
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12279 and 12280] Iowa Disaster Number IA-00024 AGENCY: U.S. Small Business Administration. ACTION: Amendment 4. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of IOWA (FEMA-1930-DR), dated 08/14/2010. Incident...
78 FR 53492 - Iowa Disaster Number IA-00053
2013-08-29
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13699 and 13700] Iowa Disaster Number IA-00053 AGENCY: U.S. Small Business Administration. Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA- 4135-DR...
75 FR 52048 - Iowa Disaster Number IA-00024
2010-08-24
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12279 and 12280] Iowa Disaster Number IA-00024 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Iowa (FEMA-1930-DR), dated 08/14/2010. Incident...
76 FR 80446 - Iowa Disaster Number IA-00033
2011-12-23
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12895 and 12896] Iowa Disaster Number IA-00033 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Iowa (FEMA-1998-DR), dated 10/18/2011. Incident...
75 FR 59750 - Iowa Disaster Number IA-00026
2010-09-28
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12258 and 12259] Iowa Disaster Number IA-00026 AGENCY: U.S. Small Business Administration. ACTION: Amendment 5. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA- 1930-DR...
75 FR 57996 - Iowa Disaster Number IA-00026
2010-09-23
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12258 and 12259] Iowa Disaster Number IA-00026 AGENCY: U.S. Small Business Administration. ACTION: Amendment 4. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA- 1930-DR...
75 FR 17178 - Iowa Disaster Number IA-00023
2010-04-05
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12062 and 12063] Iowa Disaster Number IA-00023 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA- 1880-DR...
75 FR 57088 - Iowa Disaster Number IA-00026
2010-09-17
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12258 and 12259] Iowa Disaster Number IA-00026 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA- 1930-DR...
75 FR 57997 - Iowa Disaster Number IA-00024
2010-09-23
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12279 and 12280] Iowa Disaster Number IA-00024 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Iowa (FEMA-1930-DR), dated 08/14/2010. Incident...
75 FR 58451 - Iowa Disaster Number IA-00024
2010-09-24
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12279 and 12280] Iowa Disaster Number IA-00024 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Iowa (FEMA-1930-DR), dated 08/14/2010. Incident...
78 FR 38781 - Iowa Disaster Number IA-00052
2013-06-27
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13605 and 13606] Iowa Disaster Number IA-00052 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA- 4119-DR...
76 FR 56863 - Iowa Disaster Number IA-00036
2011-09-14
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12754 and 12755] Iowa Disaster Number IA-00036 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA- 1998-DR...
78 FR 51262 - Iowa Disaster Number IA-00054
2013-08-20
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13645 and 13646] Iowa Disaster Number IA-00054 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA-- 4126--DR...
76 FR 47286 - Puerto Rico Disaster Number PR-00013
2011-08-04
... SMALL BUSINESS ADMINISTRATION Disaster Declaration 12699 and 12700 Puerto Rico Disaster Number PR-00013 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Puerto...
76 FR 67244 - Puerto Rico Disaster Number PR-00014
2011-10-31
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12768 and 12769] Puerto Rico Disaster Number PR-00014 AGENCY: U.S. Small Business Administration. ACTION: Amendment 5. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the Commonwealth of Puerto Rico (FEMA-4017...
76 FR 59179 - Puerto Rico Disaster Number PR-00014
2011-09-23
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12768 and 12769] Puerto Rico Disaster Number PR-00014 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the Commonwealth of Puerto Rico (FEMA-4017...
76 FR 59178 - Puerto Rico Disaster Number PR-00015
2011-09-23
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12770 and 12771] Puerto Rico Disaster Number PR-00015 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the...
76 FR 63699 - Puerto Rico Disaster Number PR-00015
2011-10-13
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12770 and 12771] Puerto Rico Disaster Number PR-00015 AGENCY: U.S. Small Business Administration. ACTION: Amendment 4. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the...
75 FR 76517 - Puerto Rico Disaster Number PR-00012
2010-12-08
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12368 and 12369] Puerto Rico Disaster Number PR-00012 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the...
76 FR 56858 - Puerto Rico Disaster Number PR-00014
2011-09-14
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12768 and 12769] Puerto Rico Disaster Number PR-00014 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the Commonwealth of Puerto Rico (FEMA-4017...
76 FR 62133 - Puerto Rico Disaster Number PR-00015
2011-10-06
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12770 and 12771] Puerto Rico Disaster Number PR-00015 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance only for the...
76 FR 56861 - Puerto Rico Disaster Number PR-00015
2011-09-14
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12770 and 12771] Puerto Rico Disaster Number PR-00015 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the...
75 FR 10845 - Arkansas Disaster Number AR-00042
2010-03-09
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12034 and 12035] Arkansas Disaster Number AR-00042 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...
76 FR 35937 - Arkansas Disaster Number AR-00048
2011-06-20
... U.S. SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 6. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR...
76 FR 36953 - Arkansas Disaster Number AR-00048
2011-06-23
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 7. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), dated 05/02...
76 FR 36952 - Arkansas Disaster Number AR-00049
2011-06-23
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 5. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...
76 FR 29284 - Arkansas Disaster Number AR-00049
2011-05-20
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...
76 FR 33394 - Arkansas Disaster Number AR-00048
2011-06-08
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 4. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), dated 05/02...
76 FR 33807 - Arkansas Disaster Number AR-00049
2011-06-09
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...
76 FR 35262 - Arkansas Disaster Number AR-00048
2011-06-16
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 5. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), dated 05/02...
78 FR 13742 - Arkansas Disaster Number AR-00061
2013-02-28
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13473 and 13474] Arkansas Disaster Number AR-00061 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of ARKANSAS...
76 FR 30226 - Arkansas Disaster Number AR-00048
2011-05-24
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), dated 05/02...
76 FR 35262 - Arkansas Disaster Number AR-00049
2011-06-16
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 4. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...
76 FR 36954 - Arkansas Disaster Number AR-00049
2011-06-23
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 6. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...
76 FR 41553 - Arkansas Disaster Number AR-00049
2011-07-14
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 7. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...
76 FR 28842 - Arkansas Disaster Number AR-00048
2011-05-18
... SMALL BUSINESS ADMINISTRATION Disaster Declaration 12560 and 12561 Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), 05/02/2011...
76 FR 30227 - Arkansas Disaster Number AR-00049
2011-05-24
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...
76 FR 28843 - Arkansas Disaster Number AR-00048
2011-05-18
... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), dated 05/02...
76 FR 38717 - Arkansas Disaster Number AR-00048
2011-07-01
... U.S. SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 8. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR...
Interaction between numbers and size during visual search
Krause, F.; Bekkering, H.; Pratt, J.; Lindemann, O.
2017-01-01
The current study investigates an interaction between numbers and physical size (i.e. size congruity) in visual search. In three experiments, participants had to detect a physically large (or small) target item among physically small (or large) distractors in a search task comprising single-digit
Low Nephron Number and Its Clinical Consequences
Directory of Open Access Journals (Sweden)
Valerie A. Luyckx
2011-10-01
Full Text Available decades ago, that developmental programming of the kidney impacts an individual’s risk for hypertension and renal disease in later life. Low birth weight is the strongest current clinical surrogate marker for an adverse intrauterine environment and, based on animal and human studies, is associated with a low nephron number. Other clinical correlates of low nephron number include female gender, short adult stature, small kidney size, and prematurity. Low nephron number in Caucasian and Australian Aboriginal subjects has been shown to be associated with higher blood pressures, and, conversely, hypertension is less prevalent in individuals with higher nephron numbers. In addition to nephron number, other programmed factors associated with the increased risk of hypertension include salt sensitivity, altered expression of renal sodium transporters, altered vascular reactivity, and sympathetic nervous system overactivity. Glomerular volume is universally found to vary inversely with nephron number, suggesting a degree of compensatory hypertrophy and hyperfunction in the setting of a low nephron number. This adaptation may become overwhelmed in the setting of superimposed renal insults, e.g. diabetes mellitus or rapid catch-up growth, leading to the vicious cycle of on-going hyperfiltration, proteinuria, nephron loss and progressive renal functional decline. Many millions of babies are born with low birth weight every year, and hypertension and renal disease prevalences are increasing around the globe. At present, little can be done clinically to augment nephron number; therefore adequate prenatal care and careful postnatal nutrition are crucial to optimize an individual’s nephron number during development and potentially to stem the tide of the growing cardiovascular and renal disease epidemics worldwide.
Directory of Open Access Journals (Sweden)
V. V. Zelentsov
2015-01-01
Full Text Available During the exploration of outer space (as of 1/1 2011 6853 was launched spacecraft (SC are successful 6264, representing 95% of the total number of starts. The most intensively exploited space Russia (USSR (3701 starts, 94% successful, USA (2774 starts, 90% successful, China (234 starts, 96% successful and India (89 starts, 90% successful. A small part of running the spacecraft returned to Earth (manned spacecraft and transport, and the rest remained in orbit. Some of them are descended from orbit and burned up in the atmosphere, the rest remained in the OCP and turned into space debris (SD.The composition of the Cabinet is diverse: finish the job spacecraft; boosters and the last stage of launch vehicles left in orbit after SC injection; technological waste arising during the opening drop-down structures and fragments of the destroyed spacecraft. The resulting explosion orbital SD forms ellipsoidal region which orbits blasted object. Then, as a result of precession, is the distribution of objects in orbit explosion exploding spacecraft.The whole Cabinet is divided into two factions: the observed (larger than 100 mm and not observed (less than 100 mm. Observed debris katalogalizirovan and 0.2% of the total number of SD, there was no SD is the bulk - 99.8%.SC meeting working with a fragment observed SD predictable and due to changes in altitude spacecraft avoids a possible meeting. Contact spacecraft with large fragment lead to disaster (which took place at a meeting of the Russian communications satellite "Cosmos-2251" and the American machine "Iridium". Meeting with small SD is not predictable, especially if it was formed by an explosion or collision fragments together. Orbit that KM is not predictable, and the speed can be up to 10 km / s. Meeting with small particle SD no less dangerous for the spacecraft. The impact speed of spacecraft with space debris particles can reach up to 10 ... 15 km / s at such speeds the breakdown probability thin
Allosteric small-molecule kinase inhibitors
DEFF Research Database (Denmark)
Wu, Peng; Clausen, Mads Hartvig; Nielsen, Thomas E.
2015-01-01
current barriers of kinase inhibitors, including poor selectivity and emergence of drug resistance. In spite of the small number of identified allosteric inhibitors in comparison with that of inhibitors targeting the ATP pocket, encouraging results, such as the FDA-approval of the first small...
THE RELATIONSHIP BETWEEN NUMBER NAMES AND NUMBER CONCEPTS
DEFF Research Database (Denmark)
Ejersbo, Lisser Rye; Misfeldt, Morten
Different countries have different names for numbers. These names are often related in a regular way to the base-10 place value system used for writing numbers as digits. However, in several languages, this regularity breaks down (e.g., between 10 and 20), and there is limited knowledge of how th......, a second, regular set of number names is introduced in primary school. The study’s findings suggest that the regularity of number names influences the development of number concepts and creates a positive impact on the understanding of the base-10 system....
Preghenella, Roberto
2018-02-01
In these proceedings, I report on a selection of recent LHC results in small systems from ALICE [1], ATLAS [2] and CMS [3] experiments. Due to the fact that the investigation of QCD in small systems at high multiplicity is becoming an increasingly large subject, interesting the heavy-ion community and more in general the high-energy physics community, not all the related topics can be discussed in this paper. The focus will be given to some of the measurements addressing the physics of collective phenomena in small systems and to the recent results on strangeness enhancement in proton-proton collisions. The reader must be informed that a large number of interesting results did not find space in the discussion reported here.
FACTORS CRISIS OF SMALL BUSINESS DEVELOPMENT
Directory of Open Access Journals (Sweden)
A. I. Khorev
2015-01-01
Full Text Available Today it became clear that Russia needs not only economic growth, but also economic growth of a certain quality. Re¬gions are not an exception, since they are the most vulnerable to changes in market conditions resource exports. The main economic indicators for larger regions of the country should become entrepreneurs. The main economic indicators for larger regions of the country should become entrepreneurs. Not accidentally retrospective analysis of the evolutionary development of small business shows that the most important role in the economic development of Europe and America have played and continue to play a small business. Results of activity of small businesses are generally positive; the country saw an increase in the main indicators: the number of small enterprises, the average number of employees in small enterprises, turnover of small businesses and investments in fixed assets. The statistics of recent years show a decline of interest in the business population. Number of small businesses created in the last few years there has been a downward trend, while the proportion of surviving for three years after their registration is low. The greatest negative impact on the business affairs of the factors of regulatory and administrative regulation of small business, corruption and bribery of officials and the activities of control and inspection bodies. Addressing these challenges will require proper coordination of regional and local resources in building infrastructure, forming investment mechanisms to support small enterprises, the development of the entrepreneurial potential of the population.
Closing small open economy models
Schmitt-Grohe, Stephanie; Uribe, Martín
2001-01-01
The small open economy model with incomplete asset markets features a steady state that depends on initial conditions and equilibrium dynamics that possess a random walk component. A number of modifications to the standard model have been proposed to induce stationarity. This paper presents a quantitative comparison of these alternative approaches. Five different specifications are considered: (1) A model with an endogenous discount factor (Uzawa-type preferences); (2) A model with a debt-ela...
The theory of algebraic numbers
Pollard, Harry
1998-01-01
An excellent introduction to the basics of algebraic number theory, this concise, well-written volume examines Gaussian primes; polynomials over a field; algebraic number fields; and algebraic integers and integral bases. After establishing a firm introductory foundation, the text explores the uses of arithmetic in algebraic number fields; the fundamental theorem of ideal theory and its consequences; ideal classes and class numbers; and the Fermat conjecture. 1975 edition. References. List of Symbols. Index.
Elementary number theory with programming
Lewinter, Marty
2015-01-01
A successful presentation of the fundamental concepts of number theory and computer programming Bridging an existing gap between mathematics and programming, Elementary Number Theory with Programming provides a unique introduction to elementary number theory with fundamental coverage of computer programming. Written by highly-qualified experts in the fields of computer science and mathematics, the book features accessible coverage for readers with various levels of experience and explores number theory in the context of programming without relying on advanced prerequisite knowledge and con
Distribution theory of algebraic numbers
Yang, Chung-Chun
2008-01-01
The book timely surveys new research results and related developments in Diophantine approximation, a division of number theory which deals with the approximation of real numbers by rational numbers. The book is appended with a list of challenging open problems and a comprehensive list of references. From the contents: Field extensions Algebraic numbers Algebraic geometry Height functions The abc-conjecture Roth''s theorem Subspace theorems Vojta''s conjectures L-functions.
On the Relation Between Grammatical Number and Cardinal Numbers in Development
Directory of Open Access Journals (Sweden)
Barbara W Sarnecka
2014-10-01
Full Text Available This mini-review focuses on the question of how the grammatical number system of a child’s language may help the child learn the meanings of cardinal number words (e.g., ‘one’ and ‘two’. Evidence from young children learning English, Russian, Japanese, Mandarin, Slovenian or Saudi Arabic suggests that trajectories of number-word learning differ for children learning different languages. Children learning English, which distinguishes between singular and plural, seem to learn the meaning of the cardinal number ‘one’ earlier than children learning Japanese or Mandarin, which have very little singular/plural marking. Similarly, children whose languages have a singular/dual/plural system (Slovenian and Saudi Arabic learn the meaning of ‘two’ earlier than English-speaking children. This relation between grammatical and cardinal number may shed light on how humans acquire cardinal-number concepts. There is an ongoing debate about whether mental symbols for small cardinalities (concepts for ‘oneness,’ ‘twoness,’ etc. are innate or learned. Although an effect of grammatical number on number-word learning does not rule out nativist accounts, it seems more consistent with constructivist accounts, which portray the number-learning process as one that requires significant conceptual change.
On the relation between grammatical number and cardinal numbers in development.
Sarnecka, Barbara W
2014-01-01
This mini-review focuses on the question of how the grammatical number system of a child's language may help the child learn the meanings of cardinal number words (e.g., "one" and "two"). Evidence from young children learning English, Russian, Japanese, Mandarin, Slovenian, or Saudi Arabic suggests that trajectories of number-word learning differ for children learning different languages. Children learning English, which distinguishes between singular and plural, seem to learn the meaning of the cardinal number "one" earlier than children learning Japanese or Mandarin, which have very little singular/plural marking. Similarly, children whose languages have a singular/dual/plural system (Slovenian and Saudi Arabic) learn the meaning of "two" earlier than English-speaking children. This relation between grammatical and cardinal number may shed light on how humans acquire cardinal-number concepts. There is an ongoing debate about whether mental symbols for small cardinalities (concepts for "oneness," "twoness," etc.) are innate or learned. Although an effect of grammatical number on number-word learning does not rule out nativist accounts, it seems more consistent with constructivist accounts, which portray the number-learning process as one that requires significant conceptual change.
Random Numbers and Quantum Computers
McCartney, Mark; Glass, David
2002-01-01
The topic of random numbers is investigated in such a way as to illustrate links between mathematics, physics and computer science. First, the generation of random numbers by a classical computer using the linear congruential generator and logistic map is considered. It is noted that these procedures yield only pseudo-random numbers since…
Ghersi, Dario; Parakh, Abhishek; Mezei, Mihaly
2017-12-05
Four pseudorandom number generators were compared with a physical, quantum-based random number generator using the NIST suite of statistical tests, which only the quantum-based random number generator could successfully pass. We then measured the effect of the five random number generators on various calculated properties in different Markov-chain Monte Carlo simulations. Two types of systems were tested: conformational sampling of a small molecule in aqueous solution and liquid methanol under constant temperature and pressure. The results show that poor quality pseudorandom number generators produce results that deviate significantly from those obtained with the quantum-based random number generator, particularly in the case of the small molecule in aqueous solution setup. In contrast, the widely used Mersenne Twister pseudorandom generator and a 64-bit Linear Congruential Generator with a scrambler produce results that are statistically indistinguishable from those obtained with the quantum-based random number generator. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.
SMALL ENTERPRENEURSHIP IN HOSPITALITY: CROATIAN EXPERIENCES
Directory of Open Access Journals (Sweden)
Slobodan Ivanovic
2013-03-01
Full Text Available After introductory explanations regarding the selection problems of small enterprises in the Croatian hotel industry, the author provides a number of key indicators of their role in improving the competitiveness of the Croatian hotel industry in the global tourism market. In developed tourism countries, small enterprises have a dominant share in the structure of the hotel industry, and their importance is growing even in the former socialist countries of Europe. Small hotels in Italy accounted for more than 50%, and in Austria with more than 70% of lodging facilities and represent a generator of hotel business in a large number of European tourism countries, and great attention is given to the small enterpreneurs stimulating their growth with different measures of tourist and general economy politics. The author reflects on the Croatian experience of the small businesses in the hospitality through research of development of small family hotels and their importance for the improvement of the supply of the Croatian hotel industry which future is built on personal approach to guests and present trends in the tourism market. States that the role of the National Association of family and small hotels, which represents the specific interests of small hoteliers and enables the continuous improvement of the quality of their offerings, as well as measures to encourage small business development at the macro level. Based on the made analysis the measures of increasing the efficiency of small businesses in the Croatian hospitality are given.
Generalized Bernoulli-Hurwitz numbers and the universal Bernoulli numbers
International Nuclear Information System (INIS)
Ônishi, Yoshihiro
2011-01-01
The three fundamental properties of the Bernoulli numbers, namely, the von Staudt-Clausen theorem, von Staudt's second theorem, and Kummer's original congruence, are generalized to new numbers that we call generalized Bernoulli-Hurwitz numbers. These are coefficients in the power series expansion of a higher-genus algebraic function with respect to a suitable variable. Our generalization differs strongly from previous works. Indeed, the order of the power of the modulus prime in our Kummer-type congruences is exactly the same as in the trigonometric function case (namely, Kummer's own congruence for the original Bernoulli numbers), and as in the elliptic function case (namely, H. Lang's extension for the Hurwitz numbers). However, in other past results on higher-genus algebraic functions, the modulus was at most half of its value in these classical cases. This contrast is clarified by investigating the analogue of the three properties above for the universal Bernoulli numbers. Bibliography: 34 titles.
2016 Gainesville Number Theory Conference
Garvan, Frank
2017-01-01
Gathered from the 2016 Gainesville Number Theory Conference honoring Krishna Alladi on his 60th birthday, these proceedings present recent research in number theory. Extensive and detailed, this volume features 40 articles by leading researchers on topics in analytic number theory, probabilistic number theory, irrationality and transcendence, Diophantine analysis, partitions, basic hypergeometric series, and modular forms. Readers will also find detailed discussions of several aspects of the path-breaking work of Srinivasa Ramanujan and its influence on current research. Many of the papers were motivated by Alladi's own research on partitions and q-series as well as his earlier work in number theory. Alladi is well known for his contributions in number theory and mathematics. His research interests include combinatorics, discrete mathematics, sieve methods, probabilistic and analytic number theory, Diophantine approximations, partitions and q-series identities. Graduate students and researchers will find th...
Exposition regarding small windmills
International Nuclear Information System (INIS)
1992-12-01
Emphasis is laid on the elucidation of the current situation of small windmills in Denmark by estimating the industry's strengths and weaknesses and evaluating the technical status and user economy relevant to these wind turbines, in addition to their technical and marketing potentials within the next 3-5 years. It is also attempted to survey and forecast their situation within a competitive market which includes marketing and sales potential outside Denmark, often by way of development projects financed by DANIDA (Danish International Development Agency, a department under the Danish Foreign Ministry that takes responsibility for Danish aid to developing countries, often by direct agreement). It is noted that it is difficult to make predictions in the light of currently rapidly changing global political aspects, but it is suggested that sales of smaller Danish windmills within the country could amount to 300-700 wind turbines by the year 2000. Regarding sales abroad, it is concluded that the current number will not increase unless great efforts are made within the export market and the instigation of close cooperation with foreign companies which use an international sales network and have access to local distribution channels. (AB) (15 refs.)
International Nuclear Information System (INIS)
1991-01-01
The technical reports contained in this collection of papers on research using small tokamaks fall into four main categories, i.e., (i) experimental work (heating, stability, plasma radial profiles, fluctuations and transport, confinement, ultra-low-q tokamaks, wall physics, a.o.), (ii) diagnostics (beam probes, laser scattering, X-ray tomography, laser interferometry, electron-cyclotron absorption and emission systems), (iii) theory (strong turbulence, effects of heating on stability, plasma beta limits, wave absorption, macrostability, low-q tokamak configurations and bootstrap currents, turbulent heating, stability of vortex flows, nonlinear islands growth, plasma-drift-induced anomalous transport, ergodic divertor design, a.o.), and (iv) new technical facilities (varistors applied to establish constant current and loop voltage in HT-6M), lower-hybrid-current-drive systems for HT-6B and HT-6M, radio-frequency systems for HT-6M ICR heating experimentation, and applications of fiber optics for visible and vacuum ultraviolet radiation detection as applied to tokamaks and reversed-field pinches. A total number of 51 papers are included in the collection. Refs, figs and tabs
Photon number projection using non-number-resolving detectors
International Nuclear Information System (INIS)
Rohde, Peter P; Webb, James G; Huntington, Elanor H; Ralph, Timothy C
2007-01-01
Number-resolving photo-detection is necessary for many quantum optics experiments, especially in the application of entangled state preparation. Several schemes have been proposed for approximating number-resolving photo-detection using non-number-resolving detectors. Such techniques include multi-port detection and time-division multiplexing. We provide a detailed analysis and comparison of different number-resolving detection schemes, with a view to creating a useful reference for experimentalists. We show that the ideal architecture for projective measurements is a function of the detector's dark count and efficiency parameters. We also describe a process for selecting an appropriate topology given actual experimental component parameters
Small angle spectrometers: Summary
International Nuclear Information System (INIS)
Courant, E.; Foley, K.J.; Schlein, P.E.
1986-01-01
Aspects of experiments at small angles at the Superconducting Super Collider are considered. Topics summarized include a small angle spectrometer, a high contingency spectrometer, dipole and toroid spectrometers, and magnet choices
Small Community Training & Education
Operators Small Systems Small Community Training & Education education, training and professional implement the 1996 Amendments to the Safe Drinking Water Act (SDWA). Â EPA Environmental Education Center
Number density structures in the inner heliosphere
Stansby, D.; Horbury, T. S.
2018-06-01
Aims: The origins and generation mechanisms of the slow solar wind are still unclear. Part of the slow solar wind is populated by number density structures, discrete patches of increased number density that are frozen in to and move with the bulk solar wind. In this paper we aimed to provide the first in-situ statistical study of number density structures in the inner heliosphere. Methods: We reprocessed in-situ ion distribution functions measured by Helios in the inner heliosphere to provide a new reliable set of proton plasma moments for the entire mission. From this new data set we looked for number density structures measured within 0.5 AU of the Sun and studied their properties. Results: We identified 140 discrete areas of enhanced number density. The structures occurred exclusively in the slow solar wind and spanned a wide range of length scales from 50 Mm to 2000 Mm, which includes smaller scales than have been previously observed. They were also consistently denser and hotter that the surrounding plasma, but had lower magnetic field strengths, and therefore remained in pressure balance. Conclusions: Our observations show that these structures are present in the slow solar wind at a wide range of scales, some of which are too small to be detected by remote sensing instruments. These structures are rare, accounting for only 1% of the slow solar wind measured by Helios, and are not a significant contribution to the mass flux of the solar wind.
Programming by Numbers -- A Programming Method for Complete Novices
Glaser, Hugh; Hartel, Pieter H.
2000-01-01
Students often have difficulty with the minutiae of program construction. We introduce the idea of `Programming by Numbers', which breaks some of the programming process down into smaller steps, giving such students a way into the process of Programming in the Small. Programming by Numbers does not
A twin-case study of developmental number sense impairment
Davidse, Neeltje J.; de Jong, Maria T.; Shaul, Shelley; Bus, Adriana G
2014-01-01
The current study reports on 9-year-old monozygotic twin girls who fail to make any progress in learning basic mathematics in primary education. We tested the hypothesis that the twins' core maths problems were deficits in number sense that manifested as impairments in approximate and small number
Gender Segregation Small Firms
Kenneth R Troske; William J Carrington
1992-01-01
This paper studies interfirm gender segregation in a unique sample of small employers. We focus on small firms because previous research on interfirm segregation has studied only large firms and because it is easier to link the demographic characteristics of employers and employees in small firms. This latter feature permits an assessment of the role of employer discrimination in creating gender segregation. Our first finding is that interfirm segregation is prevalent among small employers. I...
Small Business Commitment | NREL
Small Business Commitment Small Business Commitment Central to NREL's mission is our commitment to small business through a comprehensive and mature outreach program that combines proven techniques with the latest technology and best business practices. For More Information Contact Us Please email Rexann
Bernoulli numbers and zeta functions
Arakawa, Tsuneo; Kaneko, Masanobu
2014-01-01
Two major subjects are treated in this book. The main one is the theory of Bernoulli numbers and the other is the theory of zeta functions. Historically, Bernoulli numbers were introduced to give formulas for the sums of powers of consecutive integers. The real reason that they are indispensable for number theory, however, lies in the fact that special values of the Riemann zeta function can be written by using Bernoulli numbers. This leads to more advanced topics, a number of which are treated in this book: Historical remarks on Bernoulli numbers and the formula for the sum of powers of consecutive integers; a formula for Bernoulli numbers by Stirling numbers; the Clausen–von Staudt theorem on the denominators of Bernoulli numbers; Kummer's congruence between Bernoulli numbers and a related theory of p-adic measures; the Euler–Maclaurin summation formula; the functional equation of the Riemann zeta function and the Dirichlet L functions, and their special values at suitable integers; various formulas of ...
Compendium of Experimental Cetane Numbers
Energy Technology Data Exchange (ETDEWEB)
Yanowitz, Janet [Ecoengineering, Sharonville, OH (United States); Ratcliff, Matthew A. [National Renewable Energy Lab. (NREL), Golden, CO (United States); McCormick, Robert L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Taylor, J. D. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Murphy, M. J. [Battelle, Columbus, OH (United States)
2017-02-22
This report is an updated version of the 2014 Compendium of Experimental Cetane Number Data and presents a compilation of measured cetane numbers for pure chemical compounds. It includes all available single-compound cetane number data found in the scientific literature up until December 2016 as well as a number of previously unpublished values, most measured over the past decade at the National Renewable Energy Laboratory. This version of the compendium contains cetane values for 496 pure compounds, including 204 hydrocarbons and 292 oxygenates. 176 individual measurements are new to this version of the compendium, all of them collected using ASTM Method D6890, which utilizes an Ignition Quality Tester (IQT) a type of constant-volume combustion chamber. For many compounds, numerous measurements are included, often collected by different researchers using different methods. The text of this document is unchanged from the 2014 version, except for the numbers of compounds in Section 3.1, the Appendices, Table 1. Primary Cetane Number Data Sources and Table 2. Number of Measurements Included in Compendium. Cetane number is a relative ranking of a fuel's autoignition characteristics for use in compression ignition engines. It is based on the amount of time between fuel injection and ignition, also known as ignition delay. The cetane number is typically measured either in a single-cylinder engine or a constant-volume combustion chamber. Values in the previous compendium derived from octane numbers have been removed and replaced with a brief analysis of the correlation between cetane numbers and octane numbers. The discussion on the accuracy and precision of the most commonly used methods for measuring cetane number has been expanded, and the data have been annotated extensively to provide additional information that will help the reader judge the relative reliability of individual results.
Enumeration of small collections violates Weber's law.
Choo, H; Franconeri, S L
2014-02-01
In a phenomenon called subitizing, we can immediately generate exact counts of small collections (one to three objects), in contrast to larger collections, for which we must either create rough estimates or serially count. A parsimonious explanation for this advantage for small collections is that noisy representations of small collections are more tolerable, due to the larger relative differences between consecutive numbers (e.g., 2 vs. 3 is a 50 % increase, but 10 vs. 11 is only a 10 % increase). In contrast, the advantage could stem from the fact that small-collection enumeration is more precise, relying on a unique mechanism. Here, we present two experiments that conclusively showed that the enumeration of small collections is indeed "superprecise." Participants compared numerosity within either small or large visual collections in conditions in which the relative differences were controlled (e.g., performance for 2 vs. 3 was compared with performance for 20 vs. 30). Small-number comparison was still faster and more accurate, across both "more-fewer" judgments (Exp. 1), and "same-different" judgments (Exp. 2). We then reviewed the remaining potential mechanisms that might underlie this superprecision for small collections, including the greater diagnostic value of visual features that correlate with number and a limited capacity for visually individuating objects.
Vegetable oil and fat viscosity forecast models based on iodine number and saponification number
International Nuclear Information System (INIS)
Toscano, G.; Riva, G.; Foppa Pedretti, E.; Duca, D.
2012-01-01
Vegetable oil and fats can be considered as an important renewable source for the energy production. There are many applications where these biofuels are used directly in engines. However, the use of pure vegetable oils causes some problems as consequence of its chemical and physical characteristic. Viscosity is one of the most important parameters affecting several physical and mechanical processes of the operation of the engine. The determination of this parameter at different tis important to determine the behavior of the vegetable oil and fats. In this work we investigated the effects of two analytical chemical parameters (iodine number and saponification number) and forecasting models have been proposed. -- Highlights: ► Vegetable oil and fat viscosity is predicted by mathematical model based on saponification number and iodine number. ► Unsaturated vegetable oils with small size molecules of fatty acids have a lower viscosity values. ► The models proposed show an average error lower than 12%
Small hepatocellular carcinoma versus small cavernous hemangioma
International Nuclear Information System (INIS)
Choi, B.I.; Park, H.W.; Kim, S.H.; Han, M.C.; Kim, C.W.
1989-01-01
To determine the optimal pulse sequence for detection and differential diagnosis of small hepatocellular carcinomas and cavernous hemangiomas less than 5 cm in diameter, the authors have analyzed spin-echo (SE) images of 15 small hepatocellular carcinomas and 31 small cavernous hemangiomas obtained at 2.0 T. Pulse sequences used included repetition times (TRs) of 500 and 2,000 msec and echo times (TEs) of 30,60,90,120,150, and 180 msec. Mean tumor-liver contrast-to-noise ratios on the SE 2,000/60 (TR msec/TE msec) sequence were 23.90 ± 16.33 and 62.10 ± 25.94 for small hepatocellular carcinomas and hemangiomas, respectively, and were significantly greater than for all other pulse sequences. Mean tumor-liver signal intensity ratios on the SE 2,000/150 sequence were 2.34 ± 1.72 and 6.04 ± 2.72 for small hepatocellular carcinomas and hemangiomas, respectively, and were significantly greater than for all other pulse sequences in hemangiomas
Elementary number theory an algebraic approach
Bolker, Ethan D
2007-01-01
This text uses the concepts usually taught in the first semester of a modern abstract algebra course to illuminate classical number theory: theorems on primitive roots, quadratic Diophantine equations, and the Fermat conjecture for exponents three and four. The text contains abundant numerical examples and a particularly helpful collection of exercises, many of which are small research problems requiring substantial study or outside reading. Some problems call for new proofs for theorems already covered or for inductive explorations and proofs of theorems found in later chapters.Ethan D. Bolke
Improving the quark number susceptibilities for staggered fermions
International Nuclear Information System (INIS)
Gavai, Rajiv V.
2003-01-01
Quark number susceptibilities approach their ideal gas limit at sufficiently high temperatures. As in the case of other thermodynamic quantities, this limit itself is altered substantially on lattices with small temporal extent, N t = 4-8, making it thus difficult to check the validity of perturbation theory. Unlike other observables, improving susceptibilities or number densities is subject to constraints of current conservation and absence of chemical potential (μ) dependent divergences. We construct such an improved number density and susceptibility for staggered fermions and show that they approximate the continuum ideal gas limit better on small temporal lattices
Dynamic Virtual Credit Card Numbers
Molloy, Ian; Li, Jiangtao; Li, Ninghui
Theft of stored credit card information is an increasing threat to e-commerce. We propose a dynamic virtual credit card number scheme that reduces the damage caused by stolen credit card numbers. A user can use an existing credit card account to generate multiple virtual credit card numbers that are either usable for a single transaction or are tied with a particular merchant. We call the scheme dynamic because the virtual credit card numbers can be generated without online contact with the credit card issuers. These numbers can be processed without changing any of the infrastructure currently in place; the only changes will be at the end points, namely, the card users and the card issuers. We analyze the security requirements for dynamic virtual credit card numbers, discuss the design space, propose a scheme using HMAC, and prove its security under the assumption the underlying function is a PRF.
Number-unconstrained quantum sensing
Mitchell, Morgan W.
2017-12-01
Quantum sensing is commonly described as a constrained optimization problem: maximize the information gained about an unknown quantity using a limited number of particles. Important sensors including gravitational wave interferometers and some atomic sensors do not appear to fit this description, because there is no external constraint on particle number. Here, we develop the theory of particle-number-unconstrained quantum sensing, and describe how optimal particle numbers emerge from the competition of particle-environment and particle-particle interactions. We apply the theory to optical probing of an atomic medium modeled as a resonant, saturable absorber, and observe the emergence of well-defined finite optima without external constraints. The results contradict some expectations from number-constrained quantum sensing and show that probing with squeezed beams can give a large sensitivity advantage over classical strategies when each is optimized for particle number.
Schmidt number for quantum operations
International Nuclear Information System (INIS)
Huang Siendong
2006-01-01
To understand how entangled states behave under local quantum operations is an open problem in quantum-information theory. The Jamiolkowski isomorphism provides a natural way to study this problem in terms of quantum states. We introduce the Schmidt number for quantum operations by this duality and clarify how the Schmidt number of a quantum state changes under a local quantum operation. Some characterizations of quantum operations with Schmidt number k are also provided
Random number generation and creativity.
Bains, William
2008-01-01
A previous paper suggested that humans can generate genuinely random numbers. I tested this hypothesis by repeating the experiment with a larger number of highly numerate subjects, asking them to call out a sequence of digits selected from 0 through 9. The resulting sequences were substantially non-random, with an excess of sequential pairs of numbers and a deficit of repeats of the same number, in line with previous literature. However, the previous literature suggests that humans generate random numbers with substantial conscious effort, and distractions which reduce that effort reduce the randomness of the numbers. I reduced my subjects' concentration by asking them to call out in another language, and with alcohol - neither affected the randomness of their responses. This suggests that the ability to generate random numbers is a 'basic' function of the human mind, even if those numbers are not mathematically 'random'. I hypothesise that there is a 'creativity' mechanism, while not truly random, provides novelty as part of the mind's defence against closed programming loops, and that testing for the effects seen here in people more or less familiar with numbers or with spontaneous creativity could identify more features of this process. It is possible that training to perform better at simple random generation tasks could help to increase creativity, through training people to reduce the conscious mind's suppression of the 'spontaneous', creative response to new questions.
Unsolved problems in number theory
Guy, Richard K
1994-01-01
Unsolved Problems in Number Theory contains discussions of hundreds of open questions, organized into 185 different topics. They represent numerous aspects of number theory and are organized into six categories: prime numbers, divisibility, additive number theory, Diophantine equations, sequences of integers, and miscellaneous. To prevent repetition of earlier efforts or duplication of previously known results, an extensive and up-to-date collection of references follows each problem. In the second edition, not only extensive new material has been added, but corrections and additions have been included throughout the book.
Complex numbers in n dimensions
Olariu, Silviu
2002-01-01
Two distinct systems of hypercomplex numbers in n dimensions are introduced in this book, for which the multiplication is associative and commutative, and which are rich enough in properties such that exponential and trigonometric forms exist and the concepts of analytic n-complex function, contour integration and residue can be defined. The first type of hypercomplex numbers, called polar hypercomplex numbers, is characterized by the presence in an even number of dimensions greater or equal to 4 of two polar axes, and by the presence in an odd number of dimensions of one polar axis. The other type of hypercomplex numbers exists as a distinct entity only when the number of dimensions n of the space is even, and since the position of a point is specified with the aid of n/2-1 planar angles, these numbers have been called planar hypercomplex numbers. The development of the concept of analytic functions of hypercomplex variables was rendered possible by the existence of an exponential form of the n-complex numbe...
Directory of Open Access Journals (Sweden)
J. Y. Kang
2013-01-01
Full Text Available Recently, many mathematicians have studied different kinds of the Euler, Bernoulli, and Genocchi numbers and polynomials. In this paper, we give another definition of polynomials Ũn(x. We observe an interesting phenomenon of “scattering” of the zeros of the polynomials Ũn(x in complex plane. We find out some identities and properties related to polynomials Ũn(x. Finally, we also derive interesting relations between polynomials Ũn(x, Stirling numbers, central factorial numbers, and Euler numbers.
BKP and projective Hurwitz numbers
Natanzon, Sergey M.; Orlov, Aleksandr Yu.
2017-06-01
We consider d-fold branched coverings of the projective plane RP^2 and show that the hypergeometric tau function of the BKP hierarchy of Kac and van de Leur is the generating function for weighted sums of the related Hurwitz numbers. In particular, we get the RP^2 analogues of the CP^1 generating functions proposed by Okounkov and by Goulden and Jackson. Other examples are Hurwitz numbers weighted by the Hall-Littlewood and by the Macdonald polynomials. We also consider integrals of tau functions which generate Hurwitz numbers related to base surfaces with arbitrary Euler characteristics sc {e}, in particular projective Hurwitz numbers sc {e}=1.
Prandtl number of toroidal plasmas
International Nuclear Information System (INIS)
Itoh, K.; Itoh, S.; Fukuyama, A.; Yagi, M.; Azumi, M.
1993-06-01
Theory of the L-mode confinement in toroidal plasmas is developed. The Prandtl number, the ratio between the ion viscosity and the thermal conductivity is obtained for the anomalous transport process which is caused by the self-sustained turbulence in the toroidal plasma. It is found that the Prandtl number is of order unity both for the ballooning mode turbulence in tokamaks and for the interchange mode turbulence in helical system. The influence on the anomalous transport and fluctuation level is evaluated. Hartmann number and magnetic Prandtl number are also discussed. (author)
Industry Research and Recommendations for Small Buildings and Small Portfolios
Energy Technology Data Exchange (ETDEWEB)
Langner, Rois [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hendron, Bob [National Renewable Energy Lab. (NREL), Golden, CO (United States); Pless, Shanti [National Renewable Energy Lab. (NREL), Golden, CO (United States); Huppert, Mark [National Trust for Historic Preservation, Washington, DC (United States); Cochrane, Ric [National Trust for Historic Preservation, Washington, DC (United States)
2013-12-01
Small buildings have been left behind in the energy efficiency marketplace because financial and technical resources have flowed to larger commercial buildings. DOE's Building Technologies Office works with the commercial building industry to accelerate the uptake of energy efficiency technologies and techniques in existing and new commercial buildings (DOE 2013). BTO recognizes the SBSP sector'spotential for significant energy savings and the need for investments in resources that are tailored to this sector's unique needs. The industry research and recommendations described in this report identify potential approaches and strategic priorities that BTO could explore over the next 3-5 years that will support the implementation of high-potential energy efficiency opportunities for thisimportant sector. DOE is uniquely positioned to provide national leadership, objective information, and innovative tools, technologies, and services to support cost-effective energy savings in the fragmented and complex SBSP sector. Properly deployed, the DOE effort could enhance and complement current energy efficiency approaches. Small portfolios are loosely and qualitatively defined asportfolios of buildings that include only a small number of small buildings. This distinction is important because the report targets portfolio owners and managers who generally do not have staff and other resources to track energy use and pursue energy efficiency solutions.
Variation of curve number with storm depth
Banasik, K.; Hejduk, L.
2012-04-01
The NRCS Curve Number (known also as SCS-CN) method is well known as a tool in predicting flood runoff depth from small ungauged catchment. The traditional way of determination the CNs, based on soil characteristics, land use and hydrological conditions, seemed to have tendency to overpredict the floods in some cases. Over 30 year rainfall-runoff data, collected in two small (A=23.4 & 82.4 km2), lowland, agricultural catchments in Center of Poland (Banasik & Woodward 2010), were used to determine runoff Curve Number and to check a tendency of changing. The observed CN declines with increasing storm size, which according recent views of Hawkins (1993) could be classified as a standard response of watershed. The analysis concluded, that using CN value according to the procedure described in USDA-SCS Handbook one receives representative value for estimating storm runoff from high rainfall depths in the analyzes catchments. This has been confirmed by applying "asymptotic approach" for estimating the watershed curve number from the rainfall-runoff data. Furthermore, the analysis indicated that CN, estimated from mean retention parameter S of recorded events with rainfall depth higher than initial abstraction, is also approaching the theoretical CN. The observed CN, ranging from 59.8 to 97.1 and from 52.3 to 95.5, in the smaller and the larger catchment respectively, declines with increasing storm size, which has been classified as a standard response of watershed. The investigation demonstrated also changeability of the CN during a year, with much lower values during the vegetation season. Banasik K. & D.E. Woodward (2010). "Empirical determination of curve number for a small agricultural watrshed in Poland". 2nd Joint Federal Interagency Conference, Las Vegas, NV, June 27 - July 1, 2010 (http://acwi.gov/sos/pubs/2ndJFIC/Contents/10E_Banasik_ 28_02_10. pdf). Hawkins R. H. (1993). "Asymptotic determination of curve numbers from data". Journal of Irrigation and Drainage
Indian Academy of Sciences (India)
016-0309-0. Generalized r-Lah numbers. MARK SHATTUCK. Department of ...... of Dowling lattices, Discrete Math. 312. (2012) 2337–2348. [7] Hsu L C and Shiue P J-S, A unified approach to generalized Stirling numbers, Adv. Appl. Math.
Ore, Oystein
1988-01-01
A prominent mathematician presents the principal ideas and methods of number theory within a historical and cultural framework. Oystein Ore's fascinating, accessible treatment requires only a basic knowledge of algebra. Topics include prime numbers, the Aliquot parts, linear indeterminate problems, congruences, Euler's theorem, classical construction problems, and many other subjects.
Investigating the Randomness of Numbers
Pendleton, Kenn L.
2009-01-01
The use of random numbers is pervasive in today's world. Random numbers have practical applications in such far-flung arenas as computer simulations, cryptography, gambling, the legal system, statistical sampling, and even the war on terrorism. Evaluating the randomness of extremely large samples is a complex, intricate process. However, the…
Fractions, Number Lines, Third Graders
Cramer, Kathleen; Ahrendt, Sue; Monson, Debra; Wyberg, Terry; Colum, Karen
2017-01-01
The Common Core State Standards for Mathematics (CCSSM) (CCSSI 2010) outlines ambitious goals for fraction learning, starting in third grade, that include the use of the number line model. Understanding and constructing fractions on a number line are particularly complex tasks. The current work of the authors centers on ways to successfully…
Pseudo-Random Number Generators
Howell, L. W.; Rheinfurth, M. H.
1984-01-01
Package features comprehensive selection of probabilistic distributions. Monte Carlo simulations resorted to whenever systems studied not amenable to deterministic analyses or when direct experimentation not feasible. Random numbers having certain specified distribution characteristic integral part of simulations. Package consists of collector of "pseudorandom" number generators for use in Monte Carlo simulations.
On Counting the Rational Numbers
Almada, Carlos
2010-01-01
In this study, we show how to construct a function from the set N of natural numbers that explicitly counts the set Q[superscript +] of all positive rational numbers using a very intuitive approach. The function has the appeal of Cantor's function and it has the advantage that any high school student can understand the main idea at a glance…
Core Knowledge, Language, and Number
Spelke, Elizabeth S.
2017-01-01
The natural numbers may be our simplest, most useful, and best-studied abstract concepts, but their origins are debated. I consider this debate in the context of the proposal, by Gallistel and Gelman, that natural number system is a product of cognitive evolution and the proposal, by Carey, that it is a product of human cultural history. I offer a…
The Algebra of Complex Numbers.
LePage, Wilbur R.
This programed text is an introduction to the algebra of complex numbers for engineering students, particularly because of its relevance to important problems of applications in electrical engineering. It is designed for a person who is well experienced with the algebra of real numbers and calculus, but who has no experience with complex number…
Salman, M.; Broersma, Haitze J.
2003-01-01
For two given graphs $G$ and $H$, the Ramsey number $R(G,H)$ is the smallest positive integer $p$ such that for every graph $F$ on $p$ vertices the following holds: either $F$ contains $G$ as a subgraph or the complement of $F$ contains $H$ as a subgraph. In this paper, we study the Ramsey numbers
Salman, M.; Broersma, Haitze J.
For two given graphs $F$ and $H$, the Ramsey number $R(F,H)$ is the smallest positive integer $p$ such that for every graph $G$ on $p$ vertices the following holds: either $G$ contains $F$ as a subgraph or the complement of $G$ contains $H$ as a subgraph. In this paper, we study the Ramsey numbers
Salman, M.; Broersma, Haitze J.
2007-01-01
For two given graphs $F$ and $H$, the Ramsey number $R(F,H)$ is the smallest positive integer $p$ such that for every graph $G$ on $p$ vertices the following holds: either $G$ contains $F$ as a subgraph or the complement of $G$ contains $H$ as a subgraph. In this paper, we study the Ramsey numbers
Small cell glioblastoma or small cell carcinoma
DEFF Research Database (Denmark)
Hilbrandt, Christine; Sathyadas, Sathya; Dahlrot, Rikke H
2013-01-01
was admitted to the hospital with left-sided loss of motor function. A MRI revealed a 6 cm tumor in the right temporoparietal area. The histology was consistent with both glioblastoma multiforme (GBM) and small cell lung carcinoma (SCLC) but IHC was suggestive of a SCLC metastasis. PET-CT revealed...
From natural numbers to quaternions
Kramer, Jürg
2017-01-01
This textbook offers an invitation to modern algebra through number systems of increasing complexity, beginning with the natural numbers and culminating with Hamilton's quaternions. Along the way, the authors carefully develop the necessary concepts and methods from abstract algebra: monoids, groups, rings, fields, and skew fields. Each chapter ends with an appendix discussing related topics from algebra and number theory, including recent developments reflecting the relevance of the material to current research. The present volume is intended for undergraduate courses in abstract algebra or elementary number theory. The inclusion of exercises with solutions also makes it suitable for self-study and accessible to anyone with an interest in modern algebra and number theory.
Technological transfer. 2. Through developing small businesses
Energy Technology Data Exchange (ETDEWEB)
Berrie, T W; Leslie, D
1978-12-01
The transfer of small businesses to developing countries is proposed as the most effective way to build upon existing capabilities and small resources while benefiting the largest number of people. Labor-intensive small businesses require little capital investment and can bring immediate progress to both urban and rural areas. One drawback to this approach is the need for organizational effort by the government, although the Civil Service in India has been able to fill this function. Small businesses can be promoted through tax exemptions or benefits, the restriction of some manufacturing to small-scale industries, and government support of equipment research. This approach is less disruptive of social patterns and lifestyles than urbanization and its associated costs while still providing the opportunity for an improved standard of living. Electrification can be handled at the village level with diesel generators or by central power plants, although consumer cooperatives have worked better than the small business concept in this area.
International Nuclear Information System (INIS)
1991-05-01
The technical reports in this document were presented at the IAEA Technical Committee Meeting ''Research on Small Tokamaks'', September 1990, in three sessions, viz., (1) Plasma Modes, Control, and Internal Phenomena, (2) Edge Phenomena, and (3) Advanced Configurations and New Facilities. In Section (1) experiments at controlling low mode number modes, feedback control using external coils, lower-hybrid current drive for the stabilization of sawtooth activity and continuous (1,1) mode, and unmodulated and fast modulated ECRH mode stabilization experiments were reported, as well as the relation to disruptions and transport of low m,n modes and magnetic island growth; static magnetic perturbations by helical windings causing mode locking and sawtooth suppression; island widths and frequency of the m=2 tearing mode; ultra-fast cooling due to pellet injection; and, finally, some papers on advanced diagnostics, i.e., lithium-beam activated charge-exchange spectroscopy, and detection through laser scattering of discrete Alfven waves. In Section (2), experimental edge physics results from a number of machines were presented (positive biasing on HYBTOK II enhancing the radial electric field and improving confinement; lower hybrid current drive on CASTOR improving global particle confinement, good current drive efficiency in HT-6B showing stabilization of sawteeth and Mirnov oscillations), as well as diagnostic developments (multi-chord time resolved soft and ultra-soft X-ray plasma radiation detection on MT-1; measurements on electron capture cross sections in multi-charged ion-atom collisions; development of a diagnostic neutral beam on Phaedrus-T). Theoretical papers discussed the influence of sheared flow and/or active feedback on edge microstability, large edge electric fields, and two-fluid modelling of non-ambipolar scrape-off layers. Section (3) contained (i) a proposal to construct a spherical tokamak ''Proto-Eta'', (ii) an analysis of ultra-low-q and runaway
Generalized Bernoulli-Hurwitz numbers and the universal Bernoulli numbers
Energy Technology Data Exchange (ETDEWEB)
Onishi, Yoshihiro [Faculty of Education Human Sciences, University of Yamanashi, Takeda, Kofu (Japan)
2011-10-31
The three fundamental properties of the Bernoulli numbers, namely, the von Staudt-Clausen theorem, von Staudt's second theorem, and Kummer's original congruence, are generalized to new numbers that we call generalized Bernoulli-Hurwitz numbers. These are coefficients in the power series expansion of a higher-genus algebraic function with respect to a suitable variable. Our generalization differs strongly from previous works. Indeed, the order of the power of the modulus prime in our Kummer-type congruences is exactly the same as in the trigonometric function case (namely, Kummer's own congruence for the original Bernoulli numbers), and as in the elliptic function case (namely, H. Lang's extension for the Hurwitz numbers). However, in other past results on higher-genus algebraic functions, the modulus was at most half of its value in these classical cases. This contrast is clarified by investigating the analogue of the three properties above for the universal Bernoulli numbers. Bibliography: 34 titles.
International Nuclear Information System (INIS)
Donald, R.L.
1994-01-01
This paper compares the advantages and disadvantages between large and small gas utility companies. It discusses areas of construction, gaining markets, technology advances, pricing, and customer service. The paper includes discussions from four chairmen of small utility companies whom describe their perceived position among the larger companies. It also describes methods which small companies use to unite for state and nationally significant issues to voice their opinions
International Nuclear Information System (INIS)
Landshoff, P.V.
1994-01-01
Nonperturbative pomeron exchange at high energy includes minijet production. Minijets are jets whose transverse momentum is so small that they are difficult, or even impossible, to detect experimentally. At moderate Q 2 it is responsible for the small-x behaviour of νW 2 . Hence minijet production should be a feature of deep inelastic scattering at small x. (author). 9 refs., 7 figs
Low energy fermion number violation
International Nuclear Information System (INIS)
Peccei, R.D.
1989-01-01
After a brief aside on charge quantization in the standard electroweak theory, I concentrate on various aspects of anomaly induced fermion number violation in the standard model. A critical analysis of the role of sphalerons for the universe's baryon asymmetry is presented and the importance of calculating directly fermion number violating Green's functions is stressed. A physical interpretation of the recent observation of Ringwald, that coherent effects in the electroweak theory lead to catastrophic fermion number violation at 100 TeV, is discussed. Possible quantum effects which might spoil this semi-classical picture are examined
Gallistel, C R
2017-02-19
After listing functional constraints on what numbers in the brain must do, I sketch the two's complement fixed-point representation of numbers because it has stood the test of time and because it illustrates the non-obvious ways in which an effective coding scheme may operate. I briefly consider its neurobiological implementation. It is easier to imagine its implementation at the cell-intrinsic molecular level, with thermodynamically stable, volumetrically minimal polynucleotides encoding the remembered numbers, than at the circuit level, with plastic synapses encoding them.This article is part of a discussion meeting issue 'The origins of numerical abilities'. © 2017 The Author(s).
Fundamental number theory with applications
Mollin, Richard A
2008-01-01
An update of the most accessible introductory number theory text available, Fundamental Number Theory with Applications, Second Edition presents a mathematically rigorous yet easy-to-follow treatment of the fundamentals and applications of the subject. The substantial amount of reorganizing makes this edition clearer and more elementary in its coverage. New to the Second Edition Removal of all advanced material to be even more accessible in scope New fundamental material, including partition theory, generating functions, and combinatorial number theory Expa
International Nuclear Information System (INIS)
Moorhouse, E.
2010-01-01
This PowerPoint presentation discussed initiatives and strategies adopted by the Canadian Wind Energy Association (CanWEA) to support the development of Canada's small wind market. The general public has shown a significant interest in small wind projects of 300 kW. Studies have demonstrated that familiarity and comfort with small wind projects can help to ensure the successful implementation of larger wind projects. Small wind markets include residential, farming and commercial, and remote community applications. The results of CanWEA market survey show that the small wind market grew by 78 percent in 2008 over 2007, and again in 2009 by 32 percent over 2008. The average turbine size is 1 kW. A total of 11,000 turbines were purchased in 2007 and 2008. Global small wind market growth increased by 110 percent in 2008, and the average turbine size was 2.4 kW. Eighty-seven percent of the turbines made by Canadian mid-size wind turbine manufacturers are exported, and there is now a significant risk that Canada will lose its competitive advantage in small wind manufacturing as financial incentives have not been implemented. American and Canadian-based small wind manufacturers were listed, and small wind policies were reviewed. The presentation concluded with a set of recommendations for future incentives, educational programs and legislation. tabs., figs.
... disease Crohn's disease Infections Intestinal cancer Intestinal obstruction Irritable bowel syndrome Ulcers, such as peptic ulcer Treatment of disorders of the small intestine depends on the cause.
Classical theory of algebraic numbers
Ribenboim, Paulo
2001-01-01
Gauss created the theory of binary quadratic forms in "Disquisitiones Arithmeticae" and Kummer invented ideals and the theory of cyclotomic fields in his attempt to prove Fermat's Last Theorem These were the starting points for the theory of algebraic numbers, developed in the classical papers of Dedekind, Dirichlet, Eisenstein, Hermite and many others This theory, enriched with more recent contributions, is of basic importance in the study of diophantine equations and arithmetic algebraic geometry, including methods in cryptography This book has a clear and thorough exposition of the classical theory of algebraic numbers, and contains a large number of exercises as well as worked out numerical examples The Introduction is a recapitulation of results about principal ideal domains, unique factorization domains and commutative fields Part One is devoted to residue classes and quadratic residues In Part Two one finds the study of algebraic integers, ideals, units, class numbers, the theory of decomposition, iner...
Microcomputer Unit: Generating Random Numbers.
Haigh, William E.
1986-01-01
Presents an activity, suitable for students in grades 6-12, on generating random numbers. Objectives, equipment needed, list of prerequisite experiences, instructional strategies, and ready-to-copy student worksheets are included. (JN)
Number theory via Representation theory
Indian Academy of Sciences (India)
2014-11-09
Number theory via Representation theory. Eknath Ghate. November 9, 2014. Eightieth Annual Meeting, Chennai. Indian Academy of Sciences1. 1. This is a non-technical 20 minute talk intended for a general Academy audience.
Department of Homeland Security — SEVIS by the Numbers is a quarterly report that highlights nonimmigrant student and exchange visitor trends, values and information using data from the Student and...
Department of Homeland Security — SEVIS by the Numbers is a quarterly report that highlights nonimmigrant student and exchange visitor trends, values and information using data from the Student and...
Additive theory of prime numbers
Hua, L K
2009-01-01
Loo-Keng Hua was a master mathematician, best known for his work using analytic methods in number theory. In particular, Hua is remembered for his contributions to Waring's Problem and his estimates of trigonometric sums. Additive Theory of Prime Numbers is an exposition of the classic methods as well as Hua's own techniques, many of which have now also become classic. An essential starting point is Vinogradov's mean-value theorem for trigonometric sums, which Hua usefully rephrases and improves. Hua states a generalized version of the Waring-Goldbach problem and gives asymptotic formulas for the number of solutions in Waring's Problem when the monomial x^k is replaced by an arbitrary polynomial of degree k. The book is an excellent entry point for readers interested in additive number theory. It will also be of value to those interested in the development of the now classic methods of the subject.
Advanced number theory with applications
Mollin, Richard A
2009-01-01
Algebraic Number Theory and Quadratic Fields Algebraic Number Fields The Gaussian Field Euclidean Quadratic Fields Applications of Unique Factorization Ideals The Arithmetic of Ideals in Quadratic Fields Dedekind Domains Application to Factoring Binary Quadratic Forms Basics Composition and the Form Class Group Applications via Ambiguity Genus Representation Equivalence Modulo p Diophantine Approximation Algebraic and Transcendental Numbers Transcendence Minkowski's Convex Body Theorem Arithmetic Functions The Euler-Maclaurin Summation Formula Average Orders The Riemann zeta-functionIntroduction to p-Adic AnalysisSolving Modulo pn Introduction to Valuations Non-Archimedean vs. Archimedean Valuations Representation of p-Adic NumbersDirichlet: Characters, Density, and Primes in Progression Dirichlet Characters Dirichlet's L-Function and Theorem Dirichlet DensityApplications to Diophantine Equations Lucas-Lehmer Theory Generalized Ramanujan-Nagell Equations Bachet's Equation The Fermat Equation Catalan and the A...
Integral Presentations of Catalan Numbers
Dana-Picard, Thierry
2010-01-01
We compute in three different ways the same definite parametric integral. By-products are the derivation of a combinatorial identity and two integral presentations of Catalan numbers. One of them leads to a presentation using the [gamma] function.
Numbers their history and meaning
Flegg, Graham
2003-01-01
Readable, jargon-free book examines the earliest endeavors to count and record numbers, initial attempts to solve problems by using equations, and origins of infinite cardinal arithmetic. "Surprisingly exciting." - Choice.
Poison control center - emergency number
For a POISON EMERGENCY call: 1-800-222-1222 ANYWHERE IN THE UNITED STATES This national hotline number will let you ... is a free and confidential service. All local poison control centers in the United States use this ...
Women In Numbers - Europe workshop
Bucur, Alina; Feigon, Brooke; Schneps, Leila
2015-01-01
Covering topics in graph theory, L-functions, p-adic geometry, Galois representations, elliptic fibrations, genus 3 curves and bad reduction, harmonic analysis, symplectic groups and mould combinatorics, this volume presents a collection of papers covering a wide swath of number theory emerging from the third iteration of the international Women in Numbers conference, “Women in Numbers - Europe” (WINE), held on October 14–18, 2013 at the CIRM-Luminy mathematical conference center in France. While containing contributions covering a wide range of cutting-edge topics in number theory, the volume emphasizes those concrete approaches that make it possible for graduate students and postdocs to begin work immediately on research problems even in highly complex subjects.
Digital random-number generator
Brocker, D. H.
1973-01-01
For binary digit array of N bits, use N noise sources to feed N nonlinear operators; each flip-flop in digit array is set by nonlinear operator to reflect whether amplitude of generator which feeds it is above or below mean value of generated noise. Fixed-point uniform distribution random number generation method can also be used to generate random numbers with other than uniform distribution.
Random numbers from vacuum fluctuations
International Nuclear Information System (INIS)
Shi, Yicheng; Kurtsiefer, Christian; Chng, Brenda
2016-01-01
We implement a quantum random number generator based on a balanced homodyne measurement of vacuum fluctuations of the electromagnetic field. The digitized signal is directly processed with a fast randomness extraction scheme based on a linear feedback shift register. The random bit stream is continuously read in a computer at a rate of about 480 Mbit/s and passes an extended test suite for random numbers.
Numbers for reducible cubic scrolls
Directory of Open Access Journals (Sweden)
Israel Vainsencher
2004-12-01
Full Text Available We show how to compute the number of reducible cubic scrolls of codimension 2 in (math blackboard symbol Pn incident to the appropriate number of linear spaces.Mostramos como calcular o número de rolos cúbicos redutíveis de codimensão 2 em (math blackboard symbol Pn incidentes a espaços lineares apropriados.
Random numbers from vacuum fluctuations
Energy Technology Data Exchange (ETDEWEB)
Shi, Yicheng; Kurtsiefer, Christian, E-mail: christian.kurtsiefer@gmail.com [Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542 (Singapore); Center for Quantum Technologies, National University of Singapore, 3 Science Drive 2, Singapore 117543 (Singapore); Chng, Brenda [Center for Quantum Technologies, National University of Singapore, 3 Science Drive 2, Singapore 117543 (Singapore)
2016-07-25
We implement a quantum random number generator based on a balanced homodyne measurement of vacuum fluctuations of the electromagnetic field. The digitized signal is directly processed with a fast randomness extraction scheme based on a linear feedback shift register. The random bit stream is continuously read in a computer at a rate of about 480 Mbit/s and passes an extended test suite for random numbers.
Banner prints social security numbers
Robbins RA
2014-01-01
No abstract available. Article truncated at 150 words. The Monday edition of the Arizona Republic contained a story with potential interest to our readers. On the most recent address labels of Banner Health's magazine, Smart & Healthy, the addressee's Social Security or Medicare identification numbers, which are often identical to their Social Security numbers (1). The magazine was mailed to more than 50,000 recipients in Arizona late last week. The recipients are members of the Medicare Pion...
Lepton number violation in theories with a large number of standard model copies
International Nuclear Information System (INIS)
Kovalenko, Sergey; Schmidt, Ivan; Paes, Heinrich
2011-01-01
We examine lepton number violation (LNV) in theories with a saturated black hole bound on a large number of species. Such theories have been advocated recently as a possible solution to the hierarchy problem and an explanation of the smallness of neutrino masses. On the other hand, the violation of the lepton number can be a potential phenomenological problem of this N-copy extension of the standard model as due to the low quantum gravity scale black holes may induce TeV scale LNV operators generating unacceptably large rates of LNV processes. We show, however, that this issue can be avoided by introducing a spontaneously broken U 1(B-L) . Then, due to the existence of a specific compensation mechanism between contributions of different Majorana neutrino states, LNV processes in the standard model copy become extremely suppressed with rates far beyond experimental reach.
Directory of Open Access Journals (Sweden)
Saveliev Peter
2005-01-01
Full Text Available Suppose , are manifolds, are maps. The well-known coincidence problem studies the coincidence set . The number is called the codimension of the problem. More general is the preimage problem. For a map and a submanifold of , it studies the preimage set , and the codimension is . In case of codimension , the classical Nielsen number is a lower estimate of the number of points in changing under homotopies of , and for an arbitrary codimension, of the number of components of . We extend this theory to take into account other topological characteristics of . The goal is to find a "lower estimate" of the bordism group of . The answer is the Nielsen group defined as follows. In the classical definition, the Nielsen equivalence of points of based on paths is replaced with an equivalence of singular submanifolds of based on bordisms. We let , then the Nielsen group of order is the part of preserved under homotopies of . The Nielsen number of order is the rank of this group (then . These numbers are new obstructions to removability of coincidences and preimages. Some examples and computations are provided.
Grammatical typology and frequency analysis: number availability and number use
Directory of Open Access Journals (Sweden)
Dunstan Brown
2013-12-01
Full Text Available The Smith-Stark hierarchy, a version of the Animacy Hierarchy, offers a typology of the cross-linguistic availability of number. The hierarchy predicts that the availability of number is not arbitrary. For any language, if the expression of plural is available to a noun, it is available to any noun of a semantic category further to the left of the hierarchy. In this article we move one step further by showing that the structure of the hierarchy can be observed in a statistical model of number use in Russian. We also investigate three co-variates: plural preference, pluralia tantum and irregularity effects; these account for an item's behaviour being different than that solely expected from its animacy position.
Directory of Open Access Journals (Sweden)
Carroll E. Bronson
2013-05-01
Full Text Available This qualitative ethnographic case study explored the evolution of a public urban high school in its 3rd year of small school reform. The study focused on how the high school proceeded from its initial concept, moving to a small school program, and emerging as a new small high school. Data collection included interviews, observations, and document review to develop a case study of one small high school sharing a multiplex building. The first key finding, “Too Many Pieces, Not Enough Glue,” revealed that the school had too many new programs starting at once and they lacked a clear understanding of their concept and vision for their new small school, training on the Montessori philosophies, teaching and learning in small schools, and how to operate within a teacher-cooperative model. The second key finding, “A Continuous Struggle,” revealed that the shared building space presented problems for teachers and students. District policies remain unchanged, resulting in staff and students resorting to activist approaches to get things done. These findings offer small school reform leaders suggestions for developing and sustaining a small school culture and cohesion despite the pressures to revert back to top-down, comprehensive high school norms.
Sensitive Small Area Photometer
Levenson, M. D.
1970-01-01
Describes a simple photometer capable of measuring small light intensities over small areas. The inexpensive, easy-to- construct instrument is intended for use in a student laboratory to measure the light intensities in a diffraction experiment from single or multiple slits. Typical experimental results are presented along with the theoretical…
Industrial Education. "Small Engines".
Parma City School District, OH.
Part of a series of curriculum guides dealing with industrial education in junior high schools, this guide provides the student with information and manipulative experiences on small gasoline engines. Included are sections on shop adjustment, safety, small engines, internal combustion, engine construction, four stroke engines, two stroke engines,…
DEFF Research Database (Denmark)
This book offers an accessible, coherent and informative analysis of contemporary and future foreign policy challenges facing small states in Europe.......This book offers an accessible, coherent and informative analysis of contemporary and future foreign policy challenges facing small states in Europe....
International Nuclear Information System (INIS)
Kwiecinski, J.
1993-01-01
The QCD expectations concerning the small x limit of parton distributions where x is the Bjorken scaling variable are reviewed. This includes discussion of the evolutions equations in the small x region, the Lipatov equation which sums the leading powers of ln(1/x) and the shadowing effects. Phenomenological implantations of the theoretical expectations for the deep inelastic lepton-hadron scattering in the small x region which will be accessible at the HERA ep collider are described. We give predictions for structure functions F 2 and F L and discuss specific processes sensitive to the small x physics such as heavy quark production, deep inelastic diffraction and jet production in deep inelastic lepton scattering. A brief review of nuclear shadowing in the inelastic lepton nucleus scattering at small x is also presented. (author). 86 refs, 29 figs
From Natural Numbers to Numbers and Curves in Nature - II
Indian Academy of Sciences (India)
line grows from C towards both left and right. Suppose ... Let there be n steps of growth to the left, and n-l to the right. Then n .... right-hand spirals is 8 and that of left-hand .... [4] I Stewart, Nature's Numbers - Discovering Order and Pattern in the.
Number Meaning and Number Grammar in English and Spanish
Bock, Kathryn; Carreiras, Manuel; Meseguer, Enrique
2012-01-01
Grammatical agreement makes different demands on speakers of different languages. Being widespread in the languages of the world, the features of agreement systems offer valuable tests of how language affects deep-seated domains of human cognition and categorization. Number agreement is one such domain, with intriguing evidence that typological…
2014-06-01
to race, color, religion , sex, national origin, age, protected veteran status, or disability status. Lockheed Martin Operations Research analysts...Global Vision Center, Arlington, VA LSS PICK Chart Pay-Off Im pl em en ta tio n Possible Implement Challenge Kill E as y H ar d Small Big Figure...hardly noticed by the younger members of the staff. Liz Marriott, our millennial Direc- tor of Member Services, says, “Tele- commuting is very
Small polaron hopping in magnetic semiconductors
International Nuclear Information System (INIS)
Emin, D.; Liu, N.L.H.
1978-01-01
In a number of magnetic insulators it has been hypothesized that the charge carriers form small polarons. The transfer of an electron between magnetic sites and how the magnetic nature of the material affects the rate which characterizes small-polaron hops between magnetic sites were studied. The basic transfer processes are addressed from a many-electron point in which the itinerant electron is treated as indistinguishable from those which contribute unpaired spins at the magnetic sites
Source-Independent Quantum Random Number Generation
Cao, Zhu; Zhou, Hongyi; Yuan, Xiao; Ma, Xiongfeng
2016-01-01
Quantum random number generators can provide genuine randomness by appealing to the fundamental principles of quantum mechanics. In general, a physical generator contains two parts—a randomness source and its readout. The source is essential to the quality of the resulting random numbers; hence, it needs to be carefully calibrated and modeled to achieve information-theoretical provable randomness. However, in practice, the source is a complicated physical system, such as a light source or an atomic ensemble, and any deviations in the real-life implementation from the theoretical model may affect the randomness of the output. To close this gap, we propose a source-independent scheme for quantum random number generation in which output randomness can be certified, even when the source is uncharacterized and untrusted. In our randomness analysis, we make no assumptions about the dimension of the source. For instance, multiphoton emissions are allowed in optical implementations. Our analysis takes into account the finite-key effect with the composable security definition. In the limit of large data size, the length of the input random seed is exponentially small compared to that of the output random bit. In addition, by modifying a quantum key distribution system, we experimentally demonstrate our scheme and achieve a randomness generation rate of over 5 ×103 bit /s .
Theoretical perspective for baryon number violation
International Nuclear Information System (INIS)
Langacker, P.
1982-01-01
In this talk I describe the theoretical predictions for proton decay and other baryon number violating processes, emphasizing that there are many models and theories involving baryon number violation and that it is an experimental problem to distinguish between them. I first review the the theoretical predictions for the unification mass M/sub X/ and for the weak angle sin 2 theta/sub W/. It will be seen that the class of models involving an Su 3 x SU 2 x U 1 invariant desert between M/sub W/ and M/sub X/ are strongly favored. I then turn to baryon number violation. The proton lifetime and branching ratio predictions for the SU 5 and other 3-2-1 desert models are reviewed, with emphasis on distinguishing between models and on the implications of the small value of the QCD parameter lambda/sub anti MS/ that seems to be favored by the data. I then discuss the consequences of low energy supersymmetry for proton decay, nuclear effects, and models with low mass scales. Finally, I mention possible implications of the anomalously large flux of cosmic ray antiprotons that has recently been reported
Source-Independent Quantum Random Number Generation
Directory of Open Access Journals (Sweden)
Zhu Cao
2016-02-01
Full Text Available Quantum random number generators can provide genuine randomness by appealing to the fundamental principles of quantum mechanics. In general, a physical generator contains two parts—a randomness source and its readout. The source is essential to the quality of the resulting random numbers; hence, it needs to be carefully calibrated and modeled to achieve information-theoretical provable randomness. However, in practice, the source is a complicated physical system, such as a light source or an atomic ensemble, and any deviations in the real-life implementation from the theoretical model may affect the randomness of the output. To close this gap, we propose a source-independent scheme for quantum random number generation in which output randomness can be certified, even when the source is uncharacterized and untrusted. In our randomness analysis, we make no assumptions about the dimension of the source. For instance, multiphoton emissions are allowed in optical implementations. Our analysis takes into account the finite-key effect with the composable security definition. In the limit of large data size, the length of the input random seed is exponentially small compared to that of the output random bit. In addition, by modifying a quantum key distribution system, we experimentally demonstrate our scheme and achieve a randomness generation rate of over 5×10^{3} bit/s.
The MIXMAX random number generator
Savvidy, Konstantin G.
2015-11-01
In this paper, we study the randomness properties of unimodular matrix random number generators. Under well-known conditions, these discrete-time dynamical systems have the highly desirable K-mixing properties which guarantee high quality random numbers. It is found that some widely used random number generators have poor Kolmogorov entropy and consequently fail in empirical tests of randomness. These tests show that the lowest acceptable value of the Kolmogorov entropy is around 50. Next, we provide a solution to the problem of determining the maximal period of unimodular matrix generators of pseudo-random numbers. We formulate the necessary and sufficient condition to attain the maximum period and present a family of specific generators in the MIXMAX family with superior performance and excellent statistical properties. Finally, we construct three efficient algorithms for operations with the MIXMAX matrix which is a multi-dimensional generalization of the famous cat-map. First, allowing to compute the multiplication by the MIXMAX matrix with O(N) operations. Second, to recursively compute its characteristic polynomial with O(N2) operations, and third, to apply skips of large number of steps S to the sequence in O(N2 log(S)) operations.
Development of fuel number reader by ultrasonic imaging techniques
International Nuclear Information System (INIS)
Omote, T.; Yoshida, T.
1991-01-01
This paper reports on a spent fuel ID number reader using ultrasonic imaging techniques that has been developed to realize efficient and automatic verification of fuel numbers, thereby to reduce mental load and radiation exposure for operators engaged in the verification task. The ultrasonic imaging techniques for automatic fuel number recognition are described. High-speed and high reliability imaging of the spent fuel ID number are obtained by using linear array type ultrasonic probe. The ultrasonic wave is scanned by switching array probe in vertical direction, and scanned mechanically in horizontal direction. Time for imaging of spent fuel ID number on assembly was confirmed less than three seconds by these techniques. And it can recognize spent fuel ID number even if spent fuel ID number can not be visualized by an optical method because of depositing fuel number regions by soft card. In order to recognize spent fuel ID number more rapidly and more reliably, coded fuel number expressed by plural separate recesses form is developed. Every coded fuel number consists of six small holes (about 1 mm dia.) and can be marked adjacent to the existing fuel number expressed by letters and numbers
Experimental determination of Ramsey numbers.
Bian, Zhengbing; Chudak, Fabian; Macready, William G; Clark, Lane; Gaitan, Frank
2013-09-27
Ramsey theory is a highly active research area in mathematics that studies the emergence of order in large disordered structures. Ramsey numbers mark the threshold at which order first appears and are extremely difficult to calculate due to their explosive rate of growth. Recently, an algorithm that can be implemented using adiabatic quantum evolution has been proposed that calculates the two-color Ramsey numbers R(m,n). Here we present results of an experimental implementation of this algorithm and show that it correctly determines the Ramsey numbers R(3,3) and R(m,2) for 4≤m≤8. The R(8,2) computation used 84 qubits of which 28 were computational qubits. This computation is the largest experimental implementation of a scientifically meaningful adiabatic evolution algorithm that has been done to date.
Stream ciphers and number theory
Cusick, Thomas W; Renvall, Ari R
2004-01-01
This is the unique book on cross-fertilisations between stream ciphers and number theory. It systematically and comprehensively covers known connections between the two areas that are available only in research papers. Some parts of this book consist of new research results that are not available elsewhere. In addition to exercises, over thirty research problems are presented in this book. In this revised edition almost every chapter was updated, and some chapters were completely rewritten. It is useful as a textbook for a graduate course on the subject, as well as a reference book for researchers in related fields. · Unique book on interactions of stream ciphers and number theory. · Research monograph with many results not available elsewhere. · A revised edition with the most recent advances in this subject. · Over thirty research problems for stimulating interactions between the two areas. · Written by leading researchers in stream ciphers and number theory.
Sequences, groups, and number theory
Rigo, Michel
2018-01-01
This collaborative book presents recent trends on the study of sequences, including combinatorics on words and symbolic dynamics, and new interdisciplinary links to group theory and number theory. Other chapters branch out from those areas into subfields of theoretical computer science, such as complexity theory and theory of automata. The book is built around four general themes: number theory and sequences, word combinatorics, normal numbers, and group theory. Those topics are rounded out by investigations into automatic and regular sequences, tilings and theory of computation, discrete dynamical systems, ergodic theory, numeration systems, automaton semigroups, and amenable groups. This volume is intended for use by graduate students or research mathematicians, as well as computer scientists who are working in automata theory and formal language theory. With its organization around unified themes, it would also be appropriate as a supplemental text for graduate level courses.
Negative numbers and antimatter particles
International Nuclear Information System (INIS)
Tsan, Ung Chan
2012-01-01
Dirac's equation states that an electron implies the existence of an antielectron with the same mass (more generally same arithmetic properties) and opposite charge (more generally opposite algebraic properties). Subsequent observation of antielectron validated this concept. This statement can be extended to all matter particles; observation of antiproton, antineutron, antideuton … is in complete agreement with this view. Recently antihypertriton was observed and 38 atoms of antihydrogen were trapped. This opens the path for use in precise testing of nature's fundamental symmetries. The symmetric properties of a matter particle and its mirror antimatter particle seem to be well established. Interactions operate on matter particles and antimatter particles as well. Conservation of matter parallels addition operating on positive and negative numbers. Without antimatter particles, interactions of the Standard Model (electromagnetism, strong interaction and weak interaction) cannot have the structure of group. Antimatter particles are characterized by negative baryonic number A or/and negative leptonic number L. Materialization and annihilation obey conservation of A and L (associated to all known interactions), explaining why from pure energy (A = 0, L = 0) one can only obtain a pair of matter particle antimatter particle — electron antielectron, proton and antiproton — via materialization where the mass of a pair of particle antiparticle gives back to pure energy with annihilation. These two mechanisms cannot change the difference in the number of matter particles and antimatter particles. Thus from pure energy only a perfectly symmetric (in number) universe could be generated as proposed by Dirac but observation showed that our universe is not symmetric, it is a matter universe which is nevertheless neutral. Fall of reflection symmetries shattered the prejudice that there is no way to define in an absolute way right and left or matter and antimatter
Generation of photon number states
International Nuclear Information System (INIS)
Waks, Edo; Diamanti, Eleni; Yamamoto, Yoshihisa
2006-01-01
The visible light photon counter (VLPC) has the capability to discriminate photon number states, in contrast to conventional photon counters which can only detect the presence or absence of photons. We use this capability, along with the process of parametric down-conversion, to generate photon number states. We experimentally demonstrate generation of states containing 1, 2, 3 and 4 photons with high fidelity. We then explore the effect the detection efficiency of the VLPC has on the generation rate and fidelity of the created states
A necessary and sufficient condition for a real quadratic extension to have class number one
International Nuclear Information System (INIS)
Alemu, Y.
1990-02-01
We give a necessary and sufficient condition for a real quadratic extension to have class number one and discuss the applicability of the result to find the class number one fields with small discriminant. 9 refs, 3 tabs
Petropulos, Dolores; Bittner, David; Murawski, Robert; Golden, Bert
2015-01-01
The SmallSat has an unrealized potential in both the private industry and in the federal government. Currently over 70 companies, 50 universities and 17 governmental agencies are involved in SmallSat research and development. In 1994, the U.S. Army Missile and Defense mapped the moon using smallSat imagery. Since then Smart Phones have introduced this imagery to the people of the world as diverse industries watched this trend. The deployment cost of smallSats is also greatly reduced compared to traditional satellites due to the fact that multiple units can be deployed in a single mission. Imaging payloads have become more sophisticated, smaller and lighter. In addition, the growth of small technology obtained from private industries has led to the more widespread use of smallSats. This includes greater revisit rates in imagery, significantly lower costs, the ability to update technology more frequently and the ability to decrease vulnerability of enemy attacks. The popularity of smallSats show a changing mentality in this fast paced world of tomorrow. What impact has this created on the NASA communication networks now and in future years? In this project, we are developing the SmallSat Relational Database which can support a simulation of smallSats within the NASA SCaN Compatability Environment for Networks and Integrated Communications (SCENIC) Modeling and Simulation Lab. The NASA Space Communications and Networks (SCaN) Program can use this modeling to project required network support needs in the next 10 to 15 years. The SmallSat Rational Database could model smallSats just as the other SCaN databases model the more traditional larger satellites, with a few exceptions. One being that the smallSat Database is designed to be built-to-order. The SmallSat database holds various hardware configurations that can be used to model a smallSat. It will require significant effort to develop as the research material can only be populated by hand to obtain the unique data
International Nuclear Information System (INIS)
Vries, E. de
2005-01-01
The small wind sector (0.5-100 kW) is often overlooked but could provide decentralised energy systems. Small wind turbines have been used for homes, farms and small businesses for over 80 years (e.g. in the USA and the Netherlands), receiving a boost in the 1970s and 1980s following the 1973 oil crisis when a new generation of turbines entered the European and US markets. Bergey Windpower and Southwest Windpower from the USA are the market leaders in this sector in terms of sales volume but are still classed as medium-sized enterprises. Small turbines have the disadvantage of higher costs compared with large turbines due to higher manufacturing costs, technical factors associated with the tendency to use small turbines on relatively short towers, small production runs and a failure to keep up with the latest design developments such as cost-effective state-of-the-art frequency converters. Most small turbines are horizontal axis turbines, though vertical axis turbines are produced by some manufacturers. Examples of the systems available from European suppliers are described
Energy Technology Data Exchange (ETDEWEB)
Bożek, Piotr, E-mail: piotr.bozek@fis.agh.edu.pl
2016-12-15
The scenario assuming a collective expansion stage in collisions of small systems, p-A, d-Au, and {sup 3}He-Au is discussed. A review of the observables predicted in relativistic hydrodynamic models in comparison with experimental data is presented, with arguments indicating the presence of collective expansion. The limits of applicability of the hydrodynamic model are addressed. We briefly indicate possible applications of the collective flow in small systems to study the space-time dynamics at very small scales in relativistic collisions.
Yupapin, Preecha
2013-01-01
The behavior of light in small scale optics or nano/micro optical devices has shown promising results, which can be used for basic and applied research, especially in nanoelectronics. Small Scale Optics presents the use of optical nonlinear behaviors for spins, antennae, and whispering gallery modes within micro/nano devices and circuits, which can be used in many applications. This book proposes a new design for a small scale optical device-a microring resonator device. Most chapters are based on the proposed device, which uses a configuration know as a PANDA ring resonator. Analytical and nu
World Epidemiology Review, Number 105.
1978-09-13
respectively last year. Not Siberian The official stated that the Soviet virus is not related to the famous pathogenic agent which appeared in the Siberian...numbers of aphids are due to appear on the alfalfa in the near future. The infestation has approached and even exceeded the extent at which serious
Counting problems for number rings
Brakenhoff, Johannes Franciscus
2009-01-01
In this thesis we look at three counting problems connected to orders in number fields. First we study the probability that for a random polynomial f in Z[X] the ring Z[X]/f is the maximal order in Q[X]/f. Connected to this is the probability that a random polynomial has a squarefree
Linking numbers and variational method
International Nuclear Information System (INIS)
Oda, I.; Yahikozawa, S.
1989-09-01
The ordinary and generalized linking numbers for two surfaces of dimension p and n-p-1 in an n dimensional manifold are derived. We use a variational method based on the properties of topological quantum field theory in order to derive them. (author). 13 refs, 2 figs
From Calculus to Number Theory
Indian Academy of Sciences (India)
A. Raghuram
2016-11-04
Nov 4, 2016 ... diverges to infinity. This means given any number M, however large, we can add sufficiently many terms in the above series to make the sum larger than M. This was first proved by Nicole Oresme (1323-1382), a brilliant. French philosopher of his times.
RELATIONSHIP BETWEEN SLUDGE DEWATERABILITY NUMBER ...
African Journals Online (AJOL)
A representative of a sludge sample collected from the same source was filtered under the same environmental condition and the result analysed with two different concepts. One method of analysis uses Sludge Dewaterability Number, while the second employed the Carman's Specific resistance concept in sludge ...
Materiales, 1995
1995-01-01
Four booklets present articles on Spanish language and culture aimed at teachers of Spanish in the United States for student use in their classes. Number 17, "Los Jovenes Espanoles" (Spanish Youth), includes articles on Spanish youth sports, music, gangs, thoughts, and t-shirt slogans: (1) "Young Spanish Athletes"; (2)…
Materiales, 1997
1997-01-01
These three journals of contemporary cultural, historical, and social interest contain activities designed to enhance the awareness of students of Spanish as a foreign language regarding the entire panorama of daily life in Spain. Number 21 focuses on the role of modern Spanish women; their career status; female authors; and the changing place of…
On badly approximable complex numbers
DEFF Research Database (Denmark)
Esdahl-Schou, Rune; Kristensen, S.
We show that the set of complex numbers which are badly approximable by ratios of elements of , where has maximal Hausdorff dimension. In addition, the intersection of these sets is shown to have maximal dimension. The results remain true when the sets in question are intersected with a suitably...
Models for Rational Number Bases
Pedersen, Jean J.; Armbruster, Frank O.
1975-01-01
This article extends number bases to negative integers, then to positive rationals and finally to negative rationals. Methods and rules for operations in positive and negative rational bases greater than one or less than negative one are summarized in tables. Sample problems are explained and illustrated. (KM)
Residual number processing in dyscalculia.
Cappelletti, Marinella; Price, Cathy J
2014-01-01
Developmental dyscalculia - a congenital learning disability in understanding numerical concepts - is typically associated with parietal lobe abnormality. However, people with dyscalculia often retain some residual numerical abilities, reported in studies that otherwise focused on abnormalities in the dyscalculic brain. Here we took a different perspective by focusing on brain regions that support residual number processing in dyscalculia. All participants accurately performed semantic and categorical colour-decision tasks with numerical and non-numerical stimuli, with adults with dyscalculia performing slower than controls in the number semantic tasks only. Structural imaging showed less grey-matter volume in the right parietal cortex in people with dyscalculia relative to controls. Functional MRI showed that accurate number semantic judgements were maintained by parietal and inferior frontal activations that were common to adults with dyscalculia and controls, with higher activation for participants with dyscalculia than controls in the right superior frontal cortex and the left inferior frontal sulcus. Enhanced activation in these frontal areas was driven by people with dyscalculia who made faster rather than slower numerical decisions; however, activation could not be accounted for by response times per se, because it was greater for fast relative to slow dyscalculics but not greater for fast controls relative to slow dyscalculics. In conclusion, our results reveal two frontal brain regions that support efficient number processing in dyscalculia.
Residual number processing in dyscalculia
Directory of Open Access Journals (Sweden)
Marinella Cappelletti
2014-01-01
Full Text Available Developmental dyscalculia – a congenital learning disability in understanding numerical concepts – is typically associated with parietal lobe abnormality. However, people with dyscalculia often retain some residual numerical abilities, reported in studies that otherwise focused on abnormalities in the dyscalculic brain. Here we took a different perspective by focusing on brain regions that support residual number processing in dyscalculia. All participants accurately performed semantic and categorical colour-decision tasks with numerical and non-numerical stimuli, with adults with dyscalculia performing slower than controls in the number semantic tasks only. Structural imaging showed less grey-matter volume in the right parietal cortex in people with dyscalculia relative to controls. Functional MRI showed that accurate number semantic judgements were maintained by parietal and inferior frontal activations that were common to adults with dyscalculia and controls, with higher activation for participants with dyscalculia than controls in the right superior frontal cortex and the left inferior frontal sulcus. Enhanced activation in these frontal areas was driven by people with dyscalculia who made faster rather than slower numerical decisions; however, activation could not be accounted for by response times per se, because it was greater for fast relative to slow dyscalculics but not greater for fast controls relative to slow dyscalculics. In conclusion, our results reveal two frontal brain regions that support efficient number processing in dyscalculia.
Residual number processing in dyscalculia☆
Cappelletti, Marinella; Price, Cathy J.
2013-01-01
Developmental dyscalculia – a congenital learning disability in understanding numerical concepts – is typically associated with parietal lobe abnormality. However, people with dyscalculia often retain some residual numerical abilities, reported in studies that otherwise focused on abnormalities in the dyscalculic brain. Here we took a different perspective by focusing on brain regions that support residual number processing in dyscalculia. All participants accurately performed semantic and categorical colour-decision tasks with numerical and non-numerical stimuli, with adults with dyscalculia performing slower than controls in the number semantic tasks only. Structural imaging showed less grey-matter volume in the right parietal cortex in people with dyscalculia relative to controls. Functional MRI showed that accurate number semantic judgements were maintained by parietal and inferior frontal activations that were common to adults with dyscalculia and controls, with higher activation for participants with dyscalculia than controls in the right superior frontal cortex and the left inferior frontal sulcus. Enhanced activation in these frontal areas was driven by people with dyscalculia who made faster rather than slower numerical decisions; however, activation could not be accounted for by response times per se, because it was greater for fast relative to slow dyscalculics but not greater for fast controls relative to slow dyscalculics. In conclusion, our results reveal two frontal brain regions that support efficient number processing in dyscalculia. PMID:24266008
Learning Potentials in Number Blocks
DEFF Research Database (Denmark)
Majgaard, Gunver; Misfeldt, Morten; Nielsen, Jacob
2012-01-01
This paper describes an initial exploration of how an interactive cubic user-configurable modular robotic system can be used to support learning about numbers and how they are pronounced. The development is done in collaboration with a class of 7-8 year old children and their mathematics teacher....
An introduction to Catalan numbers
Roman, Steven
2015-01-01
This textbook provides an introduction to the Catalan numbers and their remarkable properties, along with their various applications in combinatorics. Intended to be accessible to students new to the subject, the book begins with more elementary topics before progressing to more mathematically sophisticated topics. Each chapter focuses on a specific combinatorial object counted by these numbers, including paths, trees, tilings of a staircase, null sums in Zn+1, interval structures, partitions, permutations, semiorders, and more. Exercises are included at the end of book, along with hints and solutions, to help students obtain a better grasp of the material. The text is ideal for undergraduate students studying combinatorics, but will also appeal to anyone with a mathematical background who has an interest in learning about the Catalan numbers. “Roman does an admirable job of providing an introduction to Catalan numbers of a different nature from the previous ones. He has made an excellent choice o...
Strouhal number for free swimming
Saadat, Mehdi; van Buren, Tyler; Floryan, Daniel; Smits, Alexander; Haj-Hariri, Hossein
2015-11-01
In this work, we present experimental results to explore the implications of free swimming for Strouhal number (as an outcome) in the context of a simple model for a fish that consists of a 2D virtual body (source of drag) and a 2D pitching foil (source of thrust) representing cruising with thunniform locomotion. The results validate the findings of Saadat and Haj-Hariri (2012): for pitching foils thrust coefficient is a function of Strouhal number for all gaits having amplitude less than a certain critical value. Equivalently, given the balance of thrust and drag forces at cruise, Strouhal number is only a function of the shape, i.e. drag coefficient and area, and essentially a constant for high enough swimming speeds for which the mild dependence of drag coefficient on the speed vanishes. Furthermore, a dimensional analysis generalizes the findings. A scaling analysis shows that the variation of Strouhal number with cruising speed is functionally related to the variation of body drag coefficient with speed. Supported by ONR MURI Grant N00014-14-1-0533.
Laser interrogation of latent vehicle registration number
Energy Technology Data Exchange (ETDEWEB)
Russo, R.E. [Lawrence Berkeley Lab., CA (United States). Energy and Environment Div.]|[Lawrence Livermore National Lab., CA (United States). Forensic Science Center; Pelkey, G.E. [City of Livermore Police Dept., CA (United States); Grant, P.; Whipple, R.E.; Andresen, B.D. [Lawrence Livermore National Lab., CA (United States). Forensic Science Center
1994-09-01
A recent investigation involved automobile registration numbers as important evidentiary specimens. In California, as in most states, small, thin metallic decals are issued to owners of vehicles each year as the registration is renewed. The decals are applied directly to the license plate of the vehicle and typically on top of the previous year`s expired decal. To afford some degree of security, the individual registration decals have been designed to tear easily; they cannot be separated from each other, but can be carefully removed intact from the metal license plate by using a razor blade. In September 1993, the City of Livermore Police Department obtained a blue 1993 California decal that had been placed over an orange 1992 decal. The two decals were being investigated as possible evidence in a case involving vehicle registration fraud. To confirm the suspicion and implicate a suspect, the department needed to known the registration number on the bottom (completely covered) 1992 decal. The authors attempted to use intense and directed light to interrogate the colored stickers. Optical illumination using a filtered white-light source partially identified the latent number. However, the most successful technique used a tunable dye laser pumped by a pulsed Nd:YAG laser. By selectively tuning the wavelength and intensity of the dye laser, backlit illumination of the decals permitted visualization of the underlying registration number through the surface of the top sticker. With optimally-tuned wavelength and intensity, 100% accuracy was obtained in identifying the sequence of latent characters. The advantage of optical techniques is their completely nondestructive nature, thus preserving the evidence for further interrogation or courtroom presentation.
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education; Volume 20; Issue 12. The Power of Small: Championing the Underdogs of Modern Medicine. Suvasini Ramaswamy Anirban Mitra. General Article Volume 20 Issue 12 December 2015 pp 1136-1153 ...
Small Intestine Cancer Treatment
... barium (a silver-white metallic compound ). The liquid coats the esophagus, stomach, and small bowel. X-rays ... made by the body or made in a laboratory are used to boost, direct, or restore the ...
International Nuclear Information System (INIS)
Frisch, W.; Hofmann, K.
1979-01-01
Problems associated with 'small leaks' are described and requirements are derived for experimental facilities and computer codes. Based on these requirements, a valuation of the existing experimental facilities and codes is presented. Facilities for integral tests in relatively large scale (ex. LOFT) are suitable for small leak test in principle, however minor changes (instrumentation, secondary side) are necessary for the evaluation of certain phenomena. The 'advanced blowdown codes' are capable of describing most of the phenomena occurring during small leak events, however a substantial amount of code development and verification is still needed. In addition, the use of transient codes in small leak analysis is demonstrated. There are some areas (neutronics feedback, influence of control system) in which the use of transient codes is possible and advantageous. (orig.) 891 HP/orig. 892 BRE [de
Prokofiev, D; Kreutzer, N; Kress, A; Wissing, F; Pfeifer, H; Stolzenburg, J-U; Dietel, A; Schwalenberg, T; Do, M; Truß, M C
2012-10-01
The frequent application of ultrasound and radiological imaging for non-urological indications in recent years has resulted in an increase in the diagnosis of small renal masses. The treatment options for patients with a small renal mass include active surveillance, surgery (both open and minimally invasive) as well as ablative techniques. As there is a risk for metastatic spread even in small renal masses surgical extirpation remains the treatment of choice in most patients. Ablative procedures, such as cryoablation and radiofrequency ablation are appropriate for old and multi-morbid patients who require active treatment of a small renal mass. Active surveillance is an alternative for high-risk patients. Meticulous patient selection by the urologist and patient preference will determine the choice of treatment option in the future.
... pouchings in the wall of the colon), or cancer. Upper GI (esophagus, stomach, or duodenum) bleeding is most often due ... begins transmitting images of the inside of the esophagus, stomach, and small bowel to a ... Bowel Disease Irritable Bowel Syndrome ...
Small bowel bacterial overgrowth
... Surgical procedures that create a loop of small intestine where excess bacteria can grow. An example is a Billroth II type of stomach removal ( gastrectomy ). Some cases of irritable bowel syndrome (IBS).
UNDERSTANDING SMALL BUSINESS SCAMS
MICHAEL T. SCHAPER; PAUL WEBER
2012-01-01
This paper provides an overview of the current state of knowledge about small business scams. A scam is a form of dishonest action, based upon an invitation to participate in an activity. Victims are encouraged, mislead or induced to voluntarily interact with the perpetrator, and ultimately to willingly surrender over money, information or other valuable resources. Common forms of scams directed towards small business include phishing, false business valuations and sales, fake overpayments, f...