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Sample records for sm-edtmp combinado con

  1. Acute toxicity of injection of 153Sm-EDTMP

    International Nuclear Information System (INIS)

    Chen Baiwei; Chai Xuehong

    2004-01-01

    Sm-153 has several distinct advantages as a radiopharmaceutical for the treat of patients with bone to skeletal metastasis. Sm-153 shows high skeletal uptake and rapid blood and nonosseous tissue clearance. Several paper have considered the toxicity of 153Sm-EDTMP. We report the acute toxicity in mice and rats after injection of 153Sm-EDTMP or unlabeled EDTMP. The EDTMP was injected to mice by 9.76, 7.8, 6.25, 5, 4 mg/Kg. The logarithmic dose of EDTMP were given to mice to determine LD50. The LD50 of EDTMP in mice is 7.1 mg/Kg. The decay of 153Sm-EDTMP for 4 months were injected to mice at dose of 225 mg/Kg. 153Sm-EDTMP were given at 4 difference dosage to rats by 74 MBq/Kg, 370 MBq/Kg, 1110 MBq/Kg, 1850 MBq/Kg. The LD50 of 153Sm-EDTMP in rats is more than 370 MBq/Kg. Although the cold EDTMP LD50 was low, chelated with Sm can decrease it's toxicity. The decay 153Sm-EDTMP can be safe at dose of 225 mg/Kg. The clinical dose will be used at 37 MBq/Kg. So there is no need to consider to acute toxicity in clinical used 153Sm-EDTMP in designated regimen because the safe range is wide enough to cover clinical used. (authors)

  2. Evaluation of Radioisotope Production Process of 153Sm and 153Sm-EDTMP Radiopharmaceuticals

    International Nuclear Information System (INIS)

    Kadarisman; Sri Hastini; Yayan Tahyan; Abidin; Dadang Hafid; Enny Lestari

    2007-01-01

    Experiments on the process of 153 Sm radioisotope and labeling of 153 Sm-EDTMP radiopharmaceuticals were carried out. This experiments included preparation of Sm 2 O 3 target, dissolution of post irradiation, determination of radioactivity concentration of 153 Sm radioisotope, radionuclide purity, EDTMP labeling, determination of radiochemical purity and pH. In these experiments the total radioactivity 153 Sm product is round about 2845.83 mCi to 36963.31 mCi, or with the radioactivity concentration between 474 mCi/ml to 6160.55 mCi/ml in the SmCl 3 solution form, each its volume is 6.0 ml, and the samarium content is 5.76 mg/ml, and the radionuclide purity of 153 Sm is 100 %. All of the 153 Sm- EDTMP radiopharmaceuticals product are fulfilled requirements the radioactivity concentration, Sm content, radiochemical purity and pH. The radioactivity concentration of 153 Sm-EDTMP radiopharmaceuticals is 37.50 mCi/ml (minimum) to 283.50 mCi/ml (highest). The pH 7.5 were 8 products, and the rest are pH 8.5. Radiochemical purity of 153 Sm-EDTMP are round about 90.00 % to 99.44 %. (author)

  3. Cytotoxic and genotoxic effects caused by {sup 153} Sm-EDTMP, combined with BrdU a thymidine analog; Efecto citotoxico y genotoxico causado por {sup 153} Sm-EDTMP, combinado con BrdU un analogo de timidina

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    Morales A, E; Ferro F, G; Morales R, P [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2006-07-01

    The ablation of the bone marrow previous to the transplant by means of radiation and chemical antineoplastics its affect indiscriminately to the healthy tissues and in particular those that are in proliferation. The objective of this work is to determine the effect of the incorporation from the BrdU to the DNA on the genotoxicity and cytotoxicity of the cells of the bone marrow caused by the radiopharmaceutical {sup 153}Sm-EDTMP. The genotoxicity was determined by the rate of erythrocytes polychromatic micro nucleates (EPC-MN) and the cytotoxicity by the frequency of EPC. Both parameters determined in peripheral blood after the BrdU administration and {sup 153}Sm-EDTMP. The combination of the BrdU and r1 radiopharmaceutical produced a bigger cytotoxicity that the radiation and the BrdU alone; on the other hand it produced a reduction of the EPC-MN produced by the radiation, suggesting that the cytotoxicity didn't allow the expression of the genotoxicity. (Author)

  4. Cytotoxic and genotoxic effects caused by {sup 153} Sm-EDTMP, combined with BrdU a thymidine analog; Efecto citotoxico y genotoxico causado por {sup 153} Sm-EDTMP, combinado con BrdU un analogo de timidina

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    Morales A, E.; Ferro F, G.; Morales R, P. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2006-07-01

    The ablation of the bone marrow previous to the transplant by means of radiation and chemical antineoplastics its affect indiscriminately to the healthy tissues and in particular those that are in proliferation. The objective of this work is to determine the effect of the incorporation from the BrdU to the DNA on the genotoxicity and cytotoxicity of the cells of the bone marrow caused by the radiopharmaceutical {sup 153}Sm-EDTMP. The genotoxicity was determined by the rate of erythrocytes polychromatic micro nucleates (EPC-MN) and the cytotoxicity by the frequency of EPC. Both parameters determined in peripheral blood after the BrdU administration and {sup 153}Sm-EDTMP. The combination of the BrdU and r1 radiopharmaceutical produced a bigger cytotoxicity that the radiation and the BrdU alone; on the other hand it produced a reduction of the EPC-MN produced by the radiation, suggesting that the cytotoxicity didn't allow the expression of the genotoxicity. (Author)

  5. In vivo and in vitro binding assay of 153Sm-EDTMP

    International Nuclear Information System (INIS)

    Chen Daming; Wang Yuqing; Jin Xiaohai; Fan Hongqiang; Bai Hongsheng; Jia Bin; Zhang Jingming

    1999-01-01

    With the waters ultra hydrogel TM 120 μm hplc column (7.7 mm x 300 mm), several experiments have been finished, including the in vitro binding assay of 153 Sm-EDTMP, 153 SmCl 3 with the Cys, BSA, mouse plasma; HPLC analysis of the urine and the extracting solution of liver homogenate after having injected the 153 Sm-EDTMP and 153 SmCl 3 2h; HPLC analysis of the production ( 153 Sm-EDTMP) radiation self-decomposition with large dose. For the HPLC analysis, the condition is the mobile phase of 0.85 mol/mL PBS (pH7.5), flow rate of 0.5 mL/min, sampling of 15 μL. The results are following: (1) The 153 SmCl 3 not only is able to bind with the mouse plasma in vitro, but also is able to be absorbed by liver in vivo; (2) 153 Sm-EDTMP is not bind with the mouse plasma, the Cys and BSA in vitro and vivo; 153 Sm-EDTMP is not found in the extracted solution of liver homogenate at n(EDTMP): n(Sm) ≥ 5:1; 153 Sm-EDTMP is not decomposed in the urine, 1 53 Sm-EDTMP is stable in vivo; (3) 153 Sm-EDTMP radiation self-decomposition is not detected with large dose in the term of validity (6 d), but two small degradation peaks have been found in the production solution after 60 d, the radiochemistry purity of production is always great than 98% during the period

  6. Cytogenetic effect of {sup 153} Sm-EDTMP in peripheral lymphocytes of patients with metastatic cancer; Efeito citogenetico do {sup 153} Sm-EDTMP em linfocitos perifericos de pacientes com cancer metastatico

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    Silva, Marcia Augusta da

    2001-07-01

    The {sup 153}Sm-EDTMP is a radiopharmaceutical used in nuclear medicine with promising results for the relief of metastatic pain. Therefore, there are few knowledge about the effects of {sup 153}Sm-EDTMP at cellular level. The present study was conduced with the aim of evaluating the cytogenetic effects of {sup 153}Sm-EDTMP in peripheral lymphocytes from patients with bone metastasis (with and without previous radio and/or chemotherapy) by the chromosome aberration technique, either in vivo or in vitro. For that, the blood samples were collected before and one hour after the endovenous administration of {sup 153}Sm-EDTMP (mean activity of 42.53+/-5.31 MBq/kg body weight), taking into account the rapid blood clearance. The principal types of structural chromosome aberrations found gaps and breaks, acentric fragments centric rings, double minutes and dicentrics. The statistical analysis showed that the group submitted to previous radio and chemotherapy before {sup 153}Sm-EDTMP administration showed significant difference in chromosome aberrations frequency one hour after the treatment. The analysis of the chromosome modal number and the kinetics of cellular cycle showed no statistical difference among the groups, suggesting that the treatment with {sup 153}Sm-EDTMP, did not influence these parameters. The carrier molecule, EDTMP, did not influence the induction of chromosome aberration. In relation to the in vitro assays, the obtained data of peripheral lymphocytes of healthy donors and patients with no previous treatment exposed to different radioactive concentration of {sup 153}Sm-EDTMP (0.046 - 1.110 MBq/mL) were better adjusted by linear regression model (Y=A+BX). The chromosome damage induced by {sup 153}Sm-EDTMP observed in vitro was about 2 fold higher than that found in vivo for the group of patients with no previous treatment. The obtained data showed that the therapy with {sup 153}Sm-EDTMP induced a few quantity of cytogenetic damages in peripheral

  7. Analysis of urine samples from metastatic bone cancer patients administered 153Sm-EDTMP

    International Nuclear Information System (INIS)

    Goeckeler, W.F.; Stoneburner, L.K.; Price, D.R.; Fordyce, W.A.

    1993-01-01

    153 Sm-EDTMP is currently undergoing clinical evaluation as a radiotherapeutic agent for the relief of pain associated with cancer metastatic to bone. These clinical studies have demonstrated biodistributions similar to those seen earlier in animals, namely, rapid clearance from blood, selective uptake in bone and in particular metastatic bone lesions. The radioactivity not deposited in bone is cleared through the kidneys into the urine. In this study, urine samples collected from 9 patients injected with 153 Sm-EDTMP underwent complexation analysis via Pharmacia SP-Sephadex C25 cation exchange chromatography. The results showed 96.9 ± 1.7% of the radioactivity in the urine to be present as a complex of 153 Sm. An HPLC method was developed and it was demonstrated that different complexes of 153 Sm could be separated. A non-radioactive analytical standard of the Sm-EDTMP chelate was synthesized, characterized and shown to have the same HPLC retention profile as the 153 -EDTMP drug product. HPLC analysis was performed on six urine samples and in each case a single radioactivity peak with an elution profile the same as that of a 153 Sm-EDTMP standard was observed. These results indicate that the 153 Sm-EDTMP chelate is excreted intact in the urine of patients. (Author)

  8. Cytogenetic effect of 153 Sm-EDTMP in peripheral lymphocytes of patients with metastatic cancer

    International Nuclear Information System (INIS)

    Silva, Marcia Augusta da

    2001-01-01

    The 153 Sm-EDTMP is a radiopharmaceutical used in nuclear medicine with promising results for the relief of metastatic pain. Therefore, there are few knowledge about the effects of 153 Sm-EDTMP at cellular level. The present study was conduced with the aim of evaluating the cytogenetic effects of 153 Sm-EDTMP in peripheral lymphocytes from patients with bone metastasis (with and without previous radio and/or chemotherapy) by the chromosome aberration technique, either in vivo or in vitro. For that, the blood samples were collected before and one hour after the endovenous administration of 153 Sm-EDTMP (mean activity of 42.53+/-5.31 MBq/kg body weight), taking into account the rapid blood clearance. The principal types of structural chromosome aberrations found gaps and breaks, acentric fragments centric rings, double minutes and dicentrics. The statistical analysis showed that the group submitted to previous radio and chemotherapy before 153 Sm-EDTMP administration showed significant difference in chromosome aberrations frequency one hour after the treatment. The analysis of the chromosome modal number and the kinetics of cellular cycle showed no statistical difference among the groups, suggesting that the treatment with 153 Sm-EDTMP, did not influence these parameters. The carrier molecule, EDTMP, did not influence the induction of chromosome aberration. In relation to the in vitro assays, the obtained data of peripheral lymphocytes of healthy donors and patients with no previous treatment exposed to different radioactive concentration of 153 Sm-EDTMP (0.046 - 1.110 MBq/mL) were better adjusted by linear regression model (Y=A+BX). The chromosome damage induced by 153 Sm-EDTMP observed in vitro was about 2 fold higher than that found in vivo for the group of patients with no previous treatment. The obtained data showed that the therapy with 153 Sm-EDTMP induced a few quantity of cytogenetic damages in peripheral lymphocytes on hour after its administration in

  9. Cytogenetic analysis of {sup 153} Sm-EDTMP in peripheral lymphocytes from patients with bone cancer metastasis; Analise citogenetica do {sup 153} Sm-EDTMP em linfocitos perifericos de pacientes com cancer osseo matastatico

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    Silva, M.A. da; Suzuki, M.F.; Rogero, J.R.; Okazaki, K. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil); Guimaraes, M.I.C.C.; Buchpiguel, C.A. [Sao Paulo Univ., SP (Brazil). Faculdade de Medicina. Centro de Medicina Nuclear

    2002-07-01

    The {sup 153} Sm-EDTMP is a radiopharmaceutical used in nuclear medicine with promising results for the relief of metastatic pain. Therefore, there are few knowledge about the effects of {sup 153} Sm-EDTMP at cellular level. The present study was conducted with the aim of evaluating the cytogenetic effects of {sup 153} Sm-EDTMP in peripheral lymphocytes from patients with bone metastasis (with and without previous radio and/or chemotherapy) by the chromosome aberration technique. For that, the blood samples were collected before and one hour after the endovenous administrations of {sup 153} Sm-EDTMP (mean activity of 42.53 {+-} 5.31 MBq/kg body weight), taking into account the rapid blood clearance. The principal types of structural chromosome aberrations found gaps and breaks, acentric fragments centric rings, double minutes and dicentrics. The statistical analysis showed that the group submitted to previous radio and chemotherapy before{sup 153} Sm-EDTMP administration showed significant difference in chromosome aberrations frequency one hour after the treatment. The analysis of the chromosome modal number and the kinetics of cellular cycle showed no statistical difference among the groups, suggesting that the treatment with {sup 153} Sm-EDTMP, did not influence these parameters. The obtained data showed that the therapy with {sup 153} Sm-EDTMP induced a few quantity of cytogenetic damages in peripheral lymphocytes one hour after its administration in patients, although, theoretically, a long term stochastic effect cannot be disregarded. (author)

  10. Multi-factor analysis on events related to hematological toxicity in 153Sm-EDTMP palliative therapy for skeletal metastases

    International Nuclear Information System (INIS)

    Zhan Hongwei; Yu Xiaoling; Ye Xiaojuan; Bao Chengkan; Sun Da; He Gangqiang

    2006-01-01

    Objective: To investigate the clinical factors related to hematological toxicity induced by intravenous samarium-153 ethylenediaminetetramethylene phosphonic acid ( 153 Sm-EDTMP) treatment. Methods A total of 206 patients with bony metastases treated with 153 Sm-EDTMP were retrospectively analyzed. Logistic regression (SPSS 10.0 for Windows) and correlation analysis were used to evaluate the factors concerned. Results: Age of the patient, number of bone metastatic lesion, chemotherapy before 153 Sm-EDTMP therapy, concurrent radiotherapy and repeat-times of 153 Sm-EDTMP treatments were found the individual factors related to hematological toxicity. Chemotherapy before 153 Sm-EDTMP, concurrent radiotherapy, medication for normal blood counting and repeat-times of 153 Sm-EDTMP treatments were the hematological toxicity factors in multi-factor analysis. Conclusion: In 153 Sm-EDTMP therapy, several factors were found related to hematological toxicity suggesting more attention be paid to the change of blood cell counting after the palliative therapy. (authors)

  11. Cytogenetic analysis of 153 Sm-EDTMP in peripheral lymphocytes from patients with bone cancer metastasis

    International Nuclear Information System (INIS)

    Silva, M.A. da; Suzuki, M.F.; Rogero, J.R.; Okazaki, K.; Guimaraes, M.I.C.C.; Buchpiguel, C.A.

    2002-01-01

    The 153 Sm-EDTMP is a radiopharmaceutical used in nuclear medicine with promising results for the relief of metastatic pain. Therefore, there are few knowledge about the effects of 153 Sm-EDTMP at cellular level. The present study was conducted with the aim of evaluating the cytogenetic effects of 153 Sm-EDTMP in peripheral lymphocytes from patients with bone metastasis (with and without previous radio and/or chemotherapy) by the chromosome aberration technique. For that, the blood samples were collected before and one hour after the endovenous administrations of 153 Sm-EDTMP (mean activity of 42.53 ± 5.31 MBq/kg body weight), taking into account the rapid blood clearance. The principal types of structural chromosome aberrations found gaps and breaks, acentric fragments centric rings, double minutes and dicentrics. The statistical analysis showed that the group submitted to previous radio and chemotherapy before 153 Sm-EDTMP administration showed significant difference in chromosome aberrations frequency one hour after the treatment. The analysis of the chromosome modal number and the kinetics of cellular cycle showed no statistical difference among the groups, suggesting that the treatment with 153 Sm-EDTMP, did not influence these parameters. The obtained data showed that the therapy with 153 Sm-EDTMP induced a few quantity of cytogenetic damages in peripheral lymphocytes one hour after its administration in patients, although, theoretically, a long term stochastic effect cannot be disregarded. (author)

  12. Fluorescence microscopic and microautoradiographic studies on apoptosis of bone tumor cells induced by 153Sm-EDTMP

    International Nuclear Information System (INIS)

    Zhu Shoupeng; Xiao Dong; Han Xiaofeng

    1997-09-01

    The apoptosis of bone tumor cells treated with internal irradiation by 153 Sm-EDTMP was studied. The morphological changes in bone tumor cells were observed by fluorescence microscopic and microautoradiographic observations. It was found that bone tumor cells internally irradiated with 153 Sm-EDTMP, displayed significant nuclear fragmentation and marked pyknosis as well as apoptotic bodies formation. The microautoradiographic study showed that 153 Sm-EDTMP could permeate through cell membrane and displayed membrane-seeking condensation in tumor cells. Soon afterwards 153 Sm-EDTMP could be phagocytized by the tumor cells and distributed in cytoplasm and nucleus in the form of phagosome. With the prolongation of observing time, the membrane-bounded apoptotic bodies was observed. With the lengthening of internal irradiation time by 153 Sm-EDTMP, the inhibition rate of proliferation of bone tumor cells increased progressively. (10 refs., 9 figs., 1 tab.)

  13. Targeted radiotherapy with Sm-153-EDTMP in nine cases of canine primary bone tumours

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    R.J. Milner

    1998-07-01

    Full Text Available Nine dogs with primary bone tumours were treated with Samarium-153-EDTMP (Sm-153- EDTMP. Conventional treatment protocols were precluded by the size of the dogs and the owners' refusal of limb amputation. All the tumours were of the appendicular skeleton; 4 were confirmed osteosarcomas. The other 5 tumours were radiologically suspect for osteosarcoma. Bone scans were performed on all dogs using Technetium-99m-methylene diphosphonate (Tc-99m-MDP before administration of Sm-153-EDTMP. Regions of interest were identified over the contralateral limb at the same site as the tumour and counts per pixel were recorded for the tumour and contralateral limb and expressed as a ratio. The dogs were given 1 injection of 37 MBq/kg (1 mCi/kg of Sm-153-EDTMP intravenously. Thoracic and primary tumour site radiographs were taken at monthly or 2-monthly intervals to monitor progression of the primary tumour and search for evidence of metastasis. Two dogs showed no response to treatment, with an increase in bone pain, and were euthanased within 1 month. In 1 dog, a tumour of the scapula underwent complete involution and the dog is considered free of disease at 20 months post Sm-153-EDTMP treatment. The overall tumourcidal effect of a single dose of Sm-153-EDTMP on primary bone tumours was difficult to evaluate in this group of dogs, as, with one exception, all the primary tumours progressed over time and the dogs were euthanased. Pain control, for which Sm-155-EDTMP is used in man, was not evident, except in the dog that responded completely to treatment.

  14. Development of a {sup 186}Re-HEDP formulation and radio pharmacokinetics comparison with {sup 153}Sm-EDTMP; Desarrollo de una formulacion de {sup 186}Re-HEDP y comparacion radiofarmacocinetica con el {sup 153}Sm-EDTMP

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    Bribiesca C, A I

    1998-12-01

    Because of the growing interest in the use of the beta emitters radiopharmaceuticals applied to therapy in different cancer cases, we developed a formulation of {sup 186} Re-HEDP (hydroxy ethylidene diphosphonate) as a pain palliative in osseous metastases. Besides serving like therapeutic agent, together with the {sup 153} Sm-EDTMP (ethylene diamine tetra methylene phosphonate), which has already been synthesized and proved, labels EHDP could be very useful like a diagnostic agent in the pursuit of the illness. The irradiation conditions for Rhenium-186 were established by ORIGIN 2 codes for TRIGA reactors. A pharmaceutical formulation was developed employing a factorial experimental design obtaining a complex with a radiochemical purity over 90 %. The complexes {sup 186} Re-HEDP {sup 153} Sm-EDTMP were intravenous administered in BALB-C mice sacrifying them in several intervals of time in order to determine the cumulated activity in each organ to perform absorbed dose calculation by MIRD methodology (Medical Internal Radiation Dose). Radio pharmacokinetic data demonstrated that both complexes follow a biexponential kinetic of first order behavior. In the case of the {sup 186} Re-HEDP the value of the {alpha} constant was 0.2789 and {beta} 0.0006 with an effective dose of 2.56 (mSv)/MBq , while for the complex {sup 153} Sm-EDTMP the values of {alpha} to and {beta} were 0.9012 and and 0.616 respectively and the effective dose was 0.262 (mSv)/MBq. In conclusion, radiopharmaceutical {sup 153} Sm-EDTMP, showed a greater bone uptake and a minor effective dose, for which it is a better radiopharmaceutical, respect to with the formulation of {sup 186} Re-HEDP. (Author)

  15. Trials to optimize dosimetry for 153Sm-EDTMP therapy to improve therapeutic effects

    International Nuclear Information System (INIS)

    Riccabona, G.; Moncayo-Naveda, R.; Oberlandstaetter, M.; Donnemiller, E.; Kendler, D.

    2001-01-01

    In a trial to improve results of therapy with 153 Sm-EDTMP for pain control in patients with disseminated bone metastases dosimetric studies were performed. Out of 30 treated patients 8 were selected for the study at random (5 breast Ca., 3 prostate Ca.). Whole body retention (WBR) of 99m Tc-DPD and 99m Tc-EDTMP was compared with WBR of 153 Sm-EDTMP. Volume of metastases and regional 99 m Tc-phosphonate uptake were assessed by SPECT and conjugated whole body scan data after phantom studies. Effective half-life was estimated also. Clinically results of pain control, side effects and changes of in vitro parameters were followed after therapy for up to 8 months. Therapy was performed in these patients with 55,5 MBq/kg body weight. Results showed an identical pattern of radioactivity distribution on 99 Tc-phosphonate and 153 Sm-EDTMP posttherapy scans, WBR of tracers and therapeutic agent was similar. Tumour volumes were 151-652 mL, count ratios metastases/normal bone 1,72-2,41, so that 6-50% of applied 153 Sm-EDTMP were concentrated in bone lesions. This gave dose estimates of 2,8-13,7 Gy in metastases. Evaluation of clinical results showed that the majority of very good results were observed in patients receiving > 10 Gy (n=3) while with lower doses only 1/4 responded very well. 1 patient was lost to follow-up due to death in the first month after therapy. Moderate and transient myelodepression (platelets) was seen in 3/7 patients without relation to Gy applied. As obviously 153 Sm concentration is not homogenous in bone metastases it can be assumed, that in border zones between tumour and bone 30-40 Gy can be delivered when 10 Gy are calculated for the whole lesion, which would explain the satisfactory therapeutic effect in our study. The dosimetric approach to 153 Sm-EDTMP therapy could necessitate the application of higher amounts of 153 Sm-EDTMP to reach adequate radiation doses in lesions without necessarily increasing risk of myelodepression and with even

  16. Kit preparation of 153Sm-EDTMP and factors affecting radiochemical purity and stability

    International Nuclear Information System (INIS)

    Ferro-Flores, G.; Tendilla, J.I.; Lopez-Gomez, M.A.; Aguilar-Hernandez, F.; Gonzalez-Zavala, M.A.; Parades-Gutierrez, L.; Avila-Ramirez, E.

    1996-01-01

    A fast kit method was developed for the production of 153 Sm-EDTMP in two steps avoiding the use of nitric acid, evaporation and sterilization of the final solution by autoclave. Methods of analysis for the determination of chemical and radiochemical purity in the radiopharmaceutical solution were established. Factors affecting radiochemical purity and stability of the complex as the molar ratio of EDTMP/Sm, concentration of phosphate buffer and neutralization of EDTMP prior kit preparation were also analyzed. The use of this radiopharmaceutical in rabbits and patients showed selective skeletal uptake. (author). 5 refs., 4 figs., 3 tabs

  17. Targeted radiotherapy of osteosarcoma using 153Sm-EDTMP. A new promising approach

    International Nuclear Information System (INIS)

    Bruland, Oe.S.; Skretting, A.; Solheim, Oe.P.; Aas, M.

    1996-01-01

    We report a case where targeted radionuclide therapy using 153 Sm-EDTMP gave substantial palliative effect. A 35-year-old male with a primary osteosarcoma located in the first lumbar vertebra relapsed with progressive back pain after conventional treatment modalities had failed. He became bedridden, and developed paraparesis and impaired bladder function. On a diagnostic bone-scan intense radioactivity was localized in the tumor. He therefore was given 153 Sm-EDTMP treatment twice, 8 weeks apart, 35 and 32 MBq/kg body weight respectively. After a few days the pain was significantly relieved and by the second radionuclide treatment the pareses subsided. For six months he was able to be up and about without any neurological signs or detectable metastases. Eventually, however, he experienced increasing local pain, developed paraparesis, was re-operated but died 4 months later. The dramatic transient improvement observed in this case warrants further exploration using 153 Sm-EDTMP as a boost technique, supplementary to conventiontal external radiotherapy. (orig.)

  18. Targeted radiotherapy of osteosarcoma using {sup 153}Sm-EDTMP. A new promising approach

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    Bruland, Oe.S. [Dept. of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Oslo (Norway); Skretting, A. [Dept. of Medical Physics and Technology, Norwegian Radium Hospital, Oslo (Norway); Solheim, Oe.P. [Dept. of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Oslo (Norway); Aas, M. [Dept. of Nuclear Medicine, Norwegian Radium Hospital, Oslo (Norway)

    1996-10-01

    We report a case where targeted radionuclide therapy using {sup 153}Sm-EDTMP gave substantial palliative effect. A 35-year-old male with a primary osteosarcoma located in the first lumbar vertebra relapsed with progressive back pain after conventional treatment modalities had failed. He became bedridden, and developed paraparesis and impaired bladder function. On a diagnostic bone-scan intense radioactivity was localized in the tumor. He therefore was given {sup 153}Sm-EDTMP treatment twice, 8 weeks apart, 35 and 32 MBq/kg body weight respectively. After a few days the pain was significantly relieved and by the second radionuclide treatment the pareses subsided. For six months he was able to be up and about without any neurological signs or detectable metastases. Eventually, however, he experienced increasing local pain, developed paraparesis, was re-operated but died 4 months later. The dramatic transient improvement observed in this case warrants further exploration using {sup 153}Sm-EDTMP as a boost technique, supplementary to conventiontal external radiotherapy. (orig.).

  19. Electron microscopic observations and DNA chain fragmentation studies on apoptosis in bone tumor cells induced by 153Sm-EDTMP

    International Nuclear Information System (INIS)

    Zhu Shoupeng; Xiao Dong; Han Xiaofeng

    1997-01-01

    The morphological changes observed by electron microscopy indicate that after internal irradiation with 153 Sm-EDTMP bone tumor cells displayed feature of apoptosis, such as margination of condensed chromatin, chromatin fragmentation, as well as the membrane bounded apoptotic bodies formation. The quantification analysis of fragmentation DNA for bone tumor cells induced by 153 Sm-EDTMP shows that the DNA fragmentation is enhanced with the prolongation of internally irradiated time. These characteristics suggest that 153 Sm-EDTMP internal irradiation could induce bone tumor cells to go to apoptosis

  20. Sm-153 EDTMP (ethylene diamine tetramethylene phosphonic acid) radiotherapeutic radiopharmaceutical

    International Nuclear Information System (INIS)

    Rehir Dahalan; Wan Anuar Wan Awang

    1999-01-01

    This work has utilized the technology used in the design of the diagnostic radiopharmaceuticals, which enabled optimum delivery of, the gamma emitting radionuclide to the target organs, enhancing the image of organ of interest. Optimal delivery of radiotherapeutic agents, minimizes the dose to the non target organs, whilst delivering destructive beta emitting radionuclide to target cancerous tissues with the hope of slowing down or completely ablating its growth. This work had been in establishing the parameters in the optimal production of Sm-153 using the MINT Research Reactor (MINTRR). This radionuclide, was then labeled to the ethylene diamine tetramethylene phosphoric acid (EDTMP) ligand, a bone-seeking complex. The results of this work have established the most suitable target form, the optimum labeling conditions and the necessary parameters to enhance the biodistribution of the Sm-153 EDTMP complex in the bone of the animal model, thus similarly in human. (author)

  1. Clinical benefit of bone-targeted radiometabolic therapy with 153Sm-EDTMP combined with chemotherapy in patients with metastatic hormone-refractory prostate cancer

    International Nuclear Information System (INIS)

    Ricci, Sergio; Pastina, Ilaria; Cianci, Claudia; Orlandini, Cinzia; Chioni, Aldo; Di Donato, Samantha; Boni, Giuseppe; Genovesi, Dario; Grosso, Mariano; AlSharif, Abedallatif; Mariani, Giuliano; Francesca, Francesco

    2007-01-01

    Bone metastases are responsible for most of the morbidity associated with hormone-refractory prostate cancer (HRPC). 153 Sm-ethylenediaminetetramethylene phosphonate ( 153 Sm-EDTMP) has been approved for palliation of painful skeletal metastases. We retrospectively investigated the possible synergistic effect on survival of 153 Sm-EDTMP (given to HRPC patients for bone pain palliation) and chemotherapy. Forty-five HRPC patients were evaluated, with a median age of 71 years. The number of metastatic bone sites was ≤10 in 25 patients and >10 in 20 patients. Median serum PSA was 224 ng/ml. Bone pain was mild in 6 patients, moderate in 16, severe in 22 and intolerable in 1. Fifteen patients were only treated with 153 Sm-EDTMP (group A), while 30 patients also received chemotherapy (estramustine phosphate or mitoxantrone plus prednisone) at variable times: between 3 and 5 months after 153 Sm-EDTMP (14 patients, group B) or within 1 month after 153 Sm-EDTMP (16 patients, group C). Haematological toxicities observed after either regimen were in general mild, consistent with common observations after either 153 Sm-EDTMP or chemotherapy, and without any additive adverse effects in the patients receiving both 153 Sm-EDTMP and chemotherapy. Bone pain palliation to some degree was induced by 153 Sm-EDTMP in 32/45 patients (71.1%), the proportion of patients with a favourable clinical response being significantly higher in group C than in group A (87.5% vs 53.3%, p = 0.0388). Also in terms of biochemical response (serum PSA levels), patients of group C performed significantly better than patients of group A (p = 0.0235). Overall median survival from the time of administration of 153 Sm-EDTMP was 15 months in the total cohort of 45 patients, and was significantly longer in group C than in either group B (30 months vs 11 months, p = 0.023) or group A (30 months vs 10 months, p = 0.008). The results of this study confirm that 153 Sm-EDTMP is effective in terms of pain relief and

  2. Effect of 153Sm-EDTMP on survival time in patients with nasopharyngeal carcinoma and multiple bone metastases

    International Nuclear Information System (INIS)

    Fan Wei; Zheng Zongyuan; Xu Guangpu

    2004-01-01

    Objective: To evaluate the effect on survival of Samarium-153-ethylene diamine tetramethylene phosphonate (153Sm-EDTMP) in patients with nasopharyngeal carcinoma (NPC) and multiple bone metastases. Methods: From 1993 to 1999, 160 patients (127 men, 33 women; median age 35 years) presented with NPC and multiple bone metastases. Of these, 40 patients had undergone chemotherapy, and 72 palliative radiotherapy. Patients were randomly divided into four groups: Group 1 (N = 20) received analgesics (control); Groups 2, 3 and 4 (N = 80, 40, and 20, respectively) received one, two or three courses, respectively, of 153Sm-EDTMP (77.7 MBq/kg/course; course interval, 4 wk). Results: Eight patients died of non-cancer-related causes, and 24 were lost to follow-up. The median survival time for Group 1 (7.8 months) was significantly less (p < 0.05) than that of Groups 2, 3 and 4 (11.6, 13.4 and 12.8 months, respectively). Patients given 153Sm-EDTMP who had had revious external radiation survived longer (p < 0.05) than those in the other treatment groups. Conclusions: Internal radiotherapy with 153Sm-EDTMP can extend survival time in patients with nasopharyngeal carcinoma and multiple bone metastases; when combined with external radiotherapy in appropriate patients, its effect on survival time is enhanced.. (authors)

  3. Preparation and examination of properties of samarium-153-EDTMP complex; Otrzymywanie chelatu kwasu etylenodiaminotetrametylenofosfonowego (EDTMP) z samarem-153 i badanie jego wlasciwosci

    Energy Technology Data Exchange (ETDEWEB)

    Nowak, M. [Institute of Atomic Energy, Otwock-Swierk (Poland); Garnuszek, P.; Lukasiewicz, A.; Wozniak, I.; Zulczyk, W. [Osrodek Badawczo-Rozwojowy Izotopow, Otwock-Swierk (Poland); Licinska, I. [Instytut Lekow, Warsaw (Poland)

    1995-12-31

    Preparation and properties of ethylenediaminetetramethylenephosphonic acid (EDTMP) as well as some properties of {sup 153}Sm-EDTMP chelate have been examined. The chelate formed by samarium-153 (46.3 h, {beta}{sup -}-decay) with EDTMP exhibits high bone uptake and can be used for treatment of disseminated, painful skeletal metastases. The purity and stability of solutions of {sup 153}Sm-EDTMP chelate were examined in a broad range of samarium concentration and {sup 153}Sm specific activity. The complex under study was examined by radio-TLC, -electrophoresis and radio-HPLC. The results obtained suggest the small size of molecules of {sup 153}Sm-EDTMP chelate as compared with molecules of ``free``EDTMP. The results of biodistribution of {sup 153}Sm-EDTMP determined in rats indicate the quick blood clearance, high deposition of radioactivity in bone and quick excretion of radioactivity into urine. No specific uptake of {sup 153}Sm-EDTMP in extra-skeletal organs was found. (author). 42 refs, 13 figs, 22 tabs.

  4. The effectiveness of samarium-153 (153Sm) lexidronam (EDTMP) in treatment of bone metastases

    International Nuclear Information System (INIS)

    Ma Yubo; Huang Gang; Liu Jianjun

    2004-01-01

    Objectives: To evaluate the effectiveness of samarium-153 (153Sm) lexidronam (EDTMP) in treatment of bone metastases. Methods: 380 patients with bone metastases were studied (221 men, 159 women; average age 65.3 y; ranged 27-91 y; average weight 59.3 kg, ranged 39-95 kg). The tumor types were prostate carcinoma (n=155), pulmonary carcinoma (n=92), breast cancer (n=57), gastric carcinoma (n=12), colorectal carcinoma (n=22), nasopharyngeal carcinoma (n=8), lymphoma (n=8), hepatic carcinoma (n=6), ovary carcinoma (n=4) and others (n=16). All patients were received 135Sm-EDTMP 0.8 or 1.0 mCi/kg during 1 to 7 course of treatment. Patients and physician evaluations were used to assess pain relief. Numbers of metastatic foci and activity of ROIs were used to observe post-therapy change in bone scanning. Results: In 380 patients, pain relief was observed in 257 patients (67.6%). Persistence of pain relief was seen through 2 to 24 weeks. The mean relief time is 5.8±3.4 weeks. KPS score was higher 10% than pre-therapy (71.2%±9.6% Vs 80.9%±10.3%, p<0.001). Numbers of metastatic foci (11.2+8.8 Vs 8.4±5.7, p<0.001) and activity of ROIs (3.28±2.04 Vs 2.15±0.94, p<0.01) were less than pre-therapy. Bone marrow suppression was mild and reversible (5.87±1.56 Vs 4.94±1.16 x 109/L). Conclusions: 153Sm-EDTMP provided relief of pain associated with bone metastases and inhibition of metastatic foci. As a relief drug of painful bone metastases, 153Sm-EDTMP is safe and effective. (authors)

  5. Development of a 186Re-HEDP formulation and radio pharmacokinetics comparison with 153Sm-EDTMP

    International Nuclear Information System (INIS)

    Bribiesca C, A.I.

    1998-01-01

    Because of the growing interest in the use of the beta emitters radiopharmaceuticals applied to therapy in different cancer cases, we developed a formulation of 186 Re-HEDP (hydroxy ethylidene diphosphonate) as a pain palliative in osseous metastases. Besides serving like therapeutic agent, together with the 153 Sm-EDTMP (ethylene diamine tetra methylene phosphonate), which has already been synthesized and proved, labels EHDP could be very useful like a diagnostic agent in the pursuit of the illness. The irradiation conditions for Rhenium-186 were established by ORIGIN 2 codes for TRIGA reactors. A pharmaceutical formulation was developed employing a factorial experimental design obtaining a complex with a radiochemical purity over 90 %. The complexes 186 Re-HEDP 153 Sm-EDTMP were intravenous administered in BALB-C mice sacrifying them in several intervals of time in order to determine the cumulated activity in each organ to perform absorbed dose calculation by MIRD methodology (Medical Internal Radiation Dose). Radio pharmacokinetic data demonstrated that both complexes follow a biexponential kinetic of first order behavior. In the case of the 186 Re-HEDP the value of the α constant was 0.2789 and β 0.0006 with an effective dose of 2.56 (mSv)/MBq , while for the complex 153 Sm-EDTMP the values of α to and β were 0.9012 and and 0.616 respectively and the effective dose was 0.262 (mSv)/MBq. In conclusion, radiopharmaceutical 153 Sm-EDTMP, showed a greater bone uptake and a minor effective dose, for which it is a better radiopharmaceutical, respect to with the formulation of 186 Re-HEDP. (Author)

  6. Preparation and examination of properties of samarium-153-EDTMP complex

    International Nuclear Information System (INIS)

    Nowak, M.; Garnuszek, P.; Lukasiewicz, A.; Wozniak, I.; Zulczyk, W.; Licinska, I.

    1995-01-01

    Preparation and properties of ethylenediaminetetramethylenephosphonic acid (EDTMP) as well as some properties of 153 Sm-EDTMP chelate have been examined. The chelate formed by samarium-153 (46.3 h, β - -decay) with EDTMP exhibits high bone uptake and can be used for treatment of disseminated, painful skeletal metastases. The purity and stability of solutions of 153 Sm-EDTMP chelate were examined in a broad range of samarium concentration and 153 Sm specific activity. The complex under study was examined by radio-TLC, -electrophoresis and radio-HPLC. The results obtained suggest the small size of molecules of 153 Sm-EDTMP chelate as compared with molecules of ''free''EDTMP. The results of biodistribution of 153 Sm-EDTMP determined in rats indicate the quick blood clearance, high deposition of radioactivity in bone and quick excretion of radioactivity into urine. No specific uptake of 153 Sm-EDTMP in extra-skeletal organs was found. (author). 42 refs, 13 figs, 22 tabs

  7. Clinical applications of 153Sm-EDTMP in treatment of multiple bone metastases in 78 patients with lung cancer

    International Nuclear Information System (INIS)

    Xiao Guoyou; Li Dangsheng; Liang Yihua; Yao Xinjuan

    2001-01-01

    Objective: To evaluate the effect of 153 Sm-EDTMP in treating patients with lung cancer and multiple bone metastases. Methods: A dose of 18.5-25.9 MBq/Kg 153 Sm-EDTMP was administered once a month to each patient through vein injection according to disease severity and body weight. 3 injections made up one therapy cycle. Results: Pain relieves were obtained in 65 patients, with an effective rate of 83.3%. Pain relief of grade I was observed in 19 patients (24.3%), grade II in 46 patients (59%) and grade III in 13 patients (16.7%), respectively. Lesions of bone metastases disappeared or shrunk in 9 patients, with a positive rate of 11.5%, which included 3 cases of grade I and 6 cases of grade II, respectively. Better effects were obtained in adenocarcinoma and squamous carcinoma than in small cell lung cancer. Conclusion: 153 Sm-EDTMP is safe and effective in treating patients with lung cancer and multiple bone metastases

  8. Evaluation of the radiosensitizing to treatment with {sup 153}Sm-EDTMP, of haematopoietic cells of the bone marrow by means of bromodeoxyuridine incorporation into DNA, in a murine model; Evaluacion de la radiosensibilizacion al tratamiento con {sup 153}Sm-EDTMP, de las celulas hemotopoyeticas de la medula osea mediante la incorporacion de bromodesoxiuridina (BrdU) en el ADN, en un modelo murino

    Energy Technology Data Exchange (ETDEWEB)

    Morales A, E.

    2008-07-01

    Bromodeoxyuridine (BrdU) has been shown to have a radiosensitizing effect, and its incorporation into DNA prior to administration of a bone-seeking radiopharmaceutical could increase the efficiency of bone marrow ablation, and even increase the specificity of radiation exposure for therapeutic purposes. The aim of the present study was to determine the effect of BrdU incorporation into DNA on the genotoxic and cytotoxic effects of samarium-153 ethylenediaminetetra-methylene phosphonate ({sup 153}Sm-EDTMP) in murine bone marrow cells. BALB/c male mice (N = 5 in each experiment) were treated with one of the following substances: a) BrdU (0.25 mg/g) b) {sup 153}-EDTMP (11.5 +- 3 MBq) c) BrdU (0.25 mg/g) plus {sup 153}Sm-EDTMP (11.5 +- MBq), there was also an untreated control. Cytotoxicity and genotoxicity were established by time-response and absorbed dose-response curves of polychromatic erythrocyte (PCE) and micro nucleated polychromatic erythrocyte (MN-PCE) frequencies, respectively, in murine peripheral blood samples in vivo. The significance of the differences between groups was determined by a variation of Dunett test for multiple groups and different-sized groups of a student test. Beta-absorbed dose fractions obtained from MNCP4B Monte Carlo computer code were used for mice bone marrow dosimetry calculations. At an average radiation absorbed dose of 0.38 Gy, 0.56 Gy and 0.82 Gy at 24, 40 and 72 h respectively, cells from animals treated with {sup 153}Sm-EDTMP showed a clear and significant induction of MN-PCE after 24 h, with the maximum response at 40 h, however, cells from group treated with BrdU plus {sup 153}Sm-EDTMP paradoxically showed MN-PCE frequencies only slightly higher than the control at the same absorbed dose. Treatment with {sup 153}Sm-EDTMP caused a slight reduction in PCE frequency, but exposure to BrdU or BrdU plus {sup 153}Sm-EDTMP induced a substantial and significant reduction in PCE frequency from 32 h to the end of the experiment (72 h

  9. Studies concerning the preparation of the 153Sm complex with EDTMP (ethylenediaminetetra methylenephosphonic acid) and other 153Sm complexes with other phosphonates, at room temperature

    International Nuclear Information System (INIS)

    Gasiglia, Haroldo Taurian

    2000-01-01

    This work presents a study on the preparation of the complexes 1 53S m - EDTMP, 153 Sm - HEDP, 153 Sm - NTMP, 153 Sm - DTPMP and 153 Sm - HDTMP at room temperature. The preparation of the complex 153 Sm - HDTMP, under heating (70 - 72 deg C), was also studied. Several factors affecting the 153 Sm - EDTMP complexing yields were studied, due to its importance for use in Nuclear Medicine. These factors were: the molar ratio [ligand] / [metal], the ligand concentration and the incubation time of the mixture ligand-metal. The preparation of this complex, in low molar ratios, was also investigated. A study of the 153 Sm - EDTMP concerning the 'in vitro' stability, when this complex was prepared in low radioactive concentrations was performed. A study on the temperature influence on its degradation, when this complex was obtained in higher radioactive concentrations, was also performed. The preparation of the complexes 153 Sm - HEDP, 153 Sm - NTMP, 153 Sm - DTPMP and 153 Sm - HDTMP was investigated by preparing the complexes in two situations: high molar ratio and ligand concentration and low molar ratio and ligand concentration. The 'in vitro' stability of each complex, obtained in low radioactive concentration was studied. In the specific case of the complex 153 Sm - HDTMP, its biological distribution in mice was performed. All the complexes were investigated by high performance liquid chromatography (HPLC) and its complexing yields were determined by other three chromatographic processes: ionic exchange, thin layer chromatography (TLC - SG) and paper chromatography. The chromatographic processes were performed by association with specific radiochemical techniques. This work also presents a comparative study on the chromatograms obtained by thin layer chromatography (TLC - SG) and paper chromatography, when evaluated by the technique of cutting the strips into pieces and the chromatograms performed directly on a radiochromatography. The shape of the chromatograms and R

  10. Samarium-153 EDTMP therapy of disseminated skeletal metastasis

    International Nuclear Information System (INIS)

    Turner, J.H.; Martindale, A.A.; Fleay, R.F.; Hoffman, R.F.; Claringbold, P.G.

    1989-01-01

    153 Sm-EDTMP (ethylenediaminetetramethylene phosphonate), prepared from a kit, was administered to 28 patients in a clinical trial of therapy for painful skeletal metastases unresponsive to all conventional treatment. The 103 keV gamma emission of 153 Sm was utilized for prospective individual estimation of beta radiation absorbed dose to red marrow to minimize myelotoxicity and provide optimum internal radiotherapy to skeletal metastases in each patient. Pain relief occurred within 14 days of administration of 153 Sm-EDTMP in 15 of 19 patients (79%) who could vie evaluated at 6 weeks, when clinical response was maximal. Duration of response ranged from 4 to 35 weeks. Recurrence of pain responded to retreatment with 153 Sm-EDTMP in five of eight cases. No dose-response relationship was apparent for pain relief but reversible myelotoxicity was frequently observed at radiation absorbed doses to bone marrow ≥270 cGy. Dosimetry calculation was based on pharmacokinetic studies of a tracer administration of 153 Sm-EDTMP in each patient. Assumptions inherent in this prospective method of predicting dose to bone marrow were validated experimentally. Biodistribution studies in rats demonstrated rapid skeletal uptake and long term retention of 153 Sm-EDTMP in bone over 5 days. Urinary clearance accounted for 40% of injected dose, and less than 0.5% of administered activity was retained in non osseous tissue. Microdensitometry of autoradiographs of sheep vertebra and femur confirmed surface uptake of 153 Sm-EDTMP in cortical bone and demonstrated relatively high trabecular bone activity which is the major component of radiation absorbed dose to bone marrow. Haematological studies in rabbits showed 153 Sm-EDTMP-induced myelotoxicity to be transient and no histopathological abnormalities were demonstrable with doses ten times greater than those administered to patients. (orig.)

  11. (153)Sm-EDTMP for pain relief of bone metastases from prostate and breast cancer and other malignancies.

    Science.gov (United States)

    Correa-González, Luis; Arteaga de Murphy, Consuelo; Pichardo-Romero, Pablo; Pedraza-López, Martha; Moreno-García, Claudia; Correa-Hernández, Luis

    2014-05-01

    Approximately 85% of patients with cancer suffer severe metastatic bone pain for which radionuclide therapy has been employed for pain palliation. We undertook this study to evaluate the pain relief effect of (153)Sm-EDTMP in Mexican patients with severe and painful bone metastases from mainly prostate, breast, and renal cancer and other malignancies. Patients (277) with intense sustained pain caused by bone metastases were referred to the Nuclear Medicine Department of the Oncology Hospital of the Mexican Social Security Institute. The patients had to have acceptable physical conditions, a previous positive (99m)Tc-MDP scan and blood values within normal range. (153)Sm-EDTMP was prepared at the Instituto Nacional de Investigaciones Nucleares (ININ) and 37 MBq/kg of body weight was injected intravenously. Pain palliation was evaluated with a visual analogue scale (VAS) and a verbal rating scale (VRS) before treatment and 3 and 12 weeks after treatment was started. The age interval of the patients was 24-92 years with a mean age of 64 ± 12 years. Mean values for hemoglobin, leukocyte and platelet counts did not statistically differ at zero time, 3 and 12 weeks after treatment. Pain intensity and relief assessment were statistically different: 9.1 ± 0.61 units initially; 4.2 ± 1.3 units 3 weeks later (54%) and after 12 weeks the pain diminished to 2.4 ± 1.4 units (74%) in the pain relief score scales. (153)Sm-EDTMP was readily available, safe and well tolerated. We conclude that (153)Sm-EDTMP was an adequate palliative agent and was the best option for our Mexican patients to relieve their severe metastatic bone pain. Copyright © 2014 IMSS. Published by Elsevier Inc. All rights reserved.

  12. Radiochemical and biological studies, including in non-human primates, towards indigenous development of 153Sm-EDTMP for metastatic bone pain palliation

    International Nuclear Information System (INIS)

    Saraswathy, P.; Mehra, K.S.; Ranganatha, D.K.; Das, M.K.; Balasubramanian, P.S.; Ananthakrishnan, M.; Ramamoorthy, N.; Gunasekaran, S.; Shanthly, N.; Retna Ponmalar, J.; Narasimhan, S.

    2001-01-01

    The combination of ease of formulation and superior biological features of 153 Sm-EDTMP in terms of safety and efficacy for metastatic bone pain palliation, together with the prospect of better logistics of production, has prompted extensive efforts by many groups world over for its preparation and evaluation. Our efforts have been directed towards exploring the feasibility for formulation of 153 Sm-EDTMP suitable for human use by neutron activation in medium flux reactors of the freely available and inexpensive natural samarium oxide target. The emphasis in biological studies was placed on tests in larger animals (monkeys) as a prelude to clinical evaluation. Feasibility to achieve reasonably high specific activity of 300-700 mCi/mg Sm at EOB with natural samarium has been adequately demonstrated. The radioeuropium contamination, estimated by γ-spectrometry to be 153 Sm-EDTMP from natural samarium at high radioactive concentrations of 40-50 mCi 153 Sm/mL, acceptable biolocalization, as revealed by both biodistribution studies in rats (femur uptake of 2-3% injected dose at 1h p.i. and retention up to 120 h p.i.) and gamma camera images in monkeys and adequate stability have been feasible. Excellent quality bone images of monkeys were recorded showing rapid clearance from blood, visualization of skeleton, clearance from kidneys within 2 hours and retention in skeleton up to 116 hours p.i. No significant activity in other soft tissues was noted. Comparative evaluation of the product prepared from enriched samarium as well as using in-house synthesized EDTMP has, likewise, revealed identical biolocalization features. EDTMP dose tolerance test in mice showed a safety factor of about 100 for a product made from natural samarium at an adult human dose of 50 mCi 153 Sm. Feasibility for production, reasonable safety and satisfactory biolocalisation of the indigenous product has been adequately established so as to warrant clinical trials in patients. (author)

  13. Evaluation of genotoxic and cytotoxic effects of {sup 153} Sm-EDTMP in peripheral blood lymphocytes of bone metastasis patients; Avaliacao dos efeitos genotoxico e citotoxico do {sup 153} Sm-EDTMP em linfocitos perifericos de pacientes com metastase ossea

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Miriam Fussae

    2003-07-01

    In this study the cellular damage in peripheral lymphocytes after exposure to {sup 153} Sm-EDTMP (Samarium-153 ethylene-diamine-tetramietylene-phosphonate) was determined using the technique of micronuclei analysis and differential coloration.{sup 153} Sm-EDTMP is a radiopharmaceutical used for pain relief in patients with bone metastases. The analysis of the frequency of micronuclei in patient blood samples obtained one hour after endovenous administration of radiopharmaceutical (41 MBq/kg) showed no statistical difference in relation to basal values in binucleated cells. However the analysis of damage distribution in mononucleated cells, showed that the patients without previous radiotherapy treatment presented a significant increase in the frequency of cells with one micronucleus and in those who had taken previous radiotherapy treatment, in cells with two or more micronuclei. The in vitro experiments conducted with the exposition of total blood to three radiation concentrations of {sup 153} Sm-EDTMP (0.370, 0.555 and 1.110 MBq/mL) during one hour showed an increase in the frequency of micronuclei and necrotic and apoptotic cells with increasing radiation dose. Dose-response curves for healthy donors and patients with bone metastasis without previous radiotherapy treatment were constructed. The comparison of the curves showed that patients presented higher radiosensitivity, either micronuclei or dead cell (necrotic or apoptotic) percentages, than healthy donors. (author)

  14. The development of Sm-153 EDTMP (ethylene diamine tetramethylene phosphonic acid), a bone seeking radiotherapeutic agent

    International Nuclear Information System (INIS)

    Rehir Dahalan; Wan Anuar Wan Awang; Shaaban Kassim

    1997-01-01

    Diagnostic radiopharmaceuticals have been the workhorse of nuclear medicine since it began in the early fifties, with the exception of radioiodine, which was also a therapeutic radiopharmaceutical. Over the years, significant advancement in the design of the diagnostic radiopharmaceuticals, have enabled optimum delivery of, the gamma emitting radionuclide to the target organs, whilst minimizing the dose to the non-target organs. This technology was utilized in this work, to deliver destructive beta emitting radionuclide to target cancerous tissues with the hope of slowing down or completely ablating its growth. This work had been in the production of Sm-153 using the MINT research reactor (MINTRR) and labeling it to the ethylene diamine tetramethylene phosphonic acid (EDTMP) ligand, a bone seeking complex. The results of this work have established the optimum labeling conditions and showed the biodistribution of the Sm-153 EDTMP complex in the rat

  15. Evaluation of genotoxic and cytotoxic effects of 153 Sm-EDTMP in peripheral blood lymphocytes of bone metastasis patients

    International Nuclear Information System (INIS)

    Suzuki, Miriam Fussae

    2003-01-01

    In this study the cellular damage in peripheral lymphocytes after exposure to 153 Sm-EDTMP (Samarium-153 ethylene-diamine-tetramietylene-phosphonate) was determined using the technique of micronuclei analysis and differential coloration. 153 Sm-EDTMP is a radiopharmaceutical used for pain relief in patients with bone metastases. The analysis of the frequency of micronuclei in patient blood samples obtained one hour after endovenous administration of radiopharmaceutical (41 MBq/kg) showed no statistical difference in relation to basal values in binucleated cells. However the analysis of damage distribution in mononucleated cells, showed that the patients without previous radiotherapy treatment presented a significant increase in the frequency of cells with one micronucleus and in those who had taken previous radiotherapy treatment, in cells with two or more micronuclei. The in vitro experiments conducted with the exposition of total blood to three radiation concentrations of 153 Sm-EDTMP (0.370, 0.555 and 1.110 MBq/mL) during one hour showed an increase in the frequency of micronuclei and necrotic and apoptotic cells with increasing radiation dose. Dose-response curves for healthy donors and patients with bone metastasis without previous radiotherapy treatment were constructed. The comparison of the curves showed that patients presented higher radiosensitivity, either micronuclei or dead cell (necrotic or apoptotic) percentages, than healthy donors. (author)

  16. Cuban experience in the obtaining of the 153Sm-EDTMP, a therapeutic agent for the relief of pain in bone metastases

    International Nuclear Information System (INIS)

    Lopez Rodriguez, M.; Hernandez Gonzalez, I.; Gamboa Marrero, R.

    1997-01-01

    The aim of this work was determine the parameters for 153S m-EDTMP preparation the labelling and the quality control methods (radiochemical and biological) for further routine production adaptability. Under the given condition of molar ratio of EDTMP:Sm 8:1, pH 7.5 and incubation at room temperature the radiochemical purity remained essentially unchanged (99%) for 8 days

  17. Cytotoxic and genotoxic effects caused by 153 Sm-EDTMP, combined with BrdU a thymidine analog

    International Nuclear Information System (INIS)

    Morales A, E.; Ferro F, G.; Morales R, P.

    2006-01-01

    The ablation of the bone marrow previous to the transplant by means of radiation and chemical antineoplastics its affect indiscriminately to the healthy tissues and in particular those that are in proliferation. The objective of this work is to determine the effect of the incorporation from the BrdU to the DNA on the genotoxicity and cytotoxicity of the cells of the bone marrow caused by the radiopharmaceutical 153 Sm-EDTMP. The genotoxicity was determined by the rate of erythrocytes polychromatic micro nucleates (EPC-MN) and the cytotoxicity by the frequency of EPC. Both parameters determined in peripheral blood after the BrdU administration and 153 Sm-EDTMP. The combination of the BrdU and r1 radiopharmaceutical produced a bigger cytotoxicity that the radiation and the BrdU alone; on the other hand it produced a reduction of the EPC-MN produced by the radiation, suggesting that the cytotoxicity didn't allow the expression of the genotoxicity. (Author)

  18. Evaluation of the radiosensitizing to treatment with 153Sm-EDTMP, of haematopoietic cells of the bone marrow by means of bromodeoxyuridine incorporation into DNA, in a murine model

    International Nuclear Information System (INIS)

    Morales A, E.

    2008-01-01

    Bromodeoxyuridine (BrdU) has been shown to have a radiosensitizing effect, and its incorporation into DNA prior to administration of a bone-seeking radiopharmaceutical could increase the efficiency of bone marrow ablation, and even increase the specificity of radiation exposure for therapeutic purposes. The aim of the present study was to determine the effect of BrdU incorporation into DNA on the genotoxic and cytotoxic effects of samarium-153 ethylenediaminetetra-methylene phosphonate ( 153 Sm-EDTMP) in murine bone marrow cells. BALB/c male mice (N = 5 in each experiment) were treated with one of the following substances: a) BrdU (0.25 mg/g) b) 153 -EDTMP (11.5 ± 3 MBq) c) BrdU (0.25 mg/g) plus 153 Sm-EDTMP (11.5 ± MBq), there was also an untreated control. Cytotoxicity and genotoxicity were established by time-response and absorbed dose-response curves of polychromatic erythrocyte (PCE) and micro nucleated polychromatic erythrocyte (MN-PCE) frequencies, respectively, in murine peripheral blood samples in vivo. The significance of the differences between groups was determined by a variation of Dunett test for multiple groups and different-sized groups of a student test. Beta-absorbed dose fractions obtained from MNCP4B Monte Carlo computer code were used for mice bone marrow dosimetry calculations. At an average radiation absorbed dose of 0.38 Gy, 0.56 Gy and 0.82 Gy at 24, 40 and 72 h respectively, cells from animals treated with 153 Sm-EDTMP showed a clear and significant induction of MN-PCE after 24 h, with the maximum response at 40 h, however, cells from group treated with BrdU plus 153 Sm-EDTMP paradoxically showed MN-PCE frequencies only slightly higher than the control at the same absorbed dose. Treatment with 153 Sm-EDTMP caused a slight reduction in PCE frequency, but exposure to BrdU or BrdU plus 153 Sm-EDTMP induced a substantial and significant reduction in PCE frequency from 32 h to the end of the experiment (72 h). The PCE frequencies in the Brd

  19. Some radiation protection problems connected with the use of 186Re-HEDP and 153Sm-EDTMP for palliative therapy of of bone metastases

    International Nuclear Information System (INIS)

    Husak, V.; Myslivecek, M.

    1995-01-01

    The aim of this paper was to assess whether the ambulatory (outpatient) therapy with 186 Re-HEDP and 153 Sm-EDTMP is possible in the Czech Republic. Physical characteristics, administered activity, biokinetics of radiopharmaceuticals, radiation protection characteristics, irradiation of patients relatives as well as comparison with limits for rhenium-186 and samarium-153 radiopharmaceuticals are given. The outpatient administration of 186 Re-HEDP and 153 Sm-EDTMP with the subsequent keeping the patient for 6 hours in a department of nuclear medicine appears to be in compliance with regulations proposed in the Czech Republic as well as ICRP Recommendations. (J.K.) 1 tab., 12 refs

  20. Some radiation protection problems connected with the use of 186Re-HEDP and 153Sm-EDTMP for palliative therapy of of bone metastases

    Energy Technology Data Exchange (ETDEWEB)

    Husak, V; Myslivecek, M [Univ. Hospital, Olomouc (Czech Republic). Department of Nuclear Medicine

    1996-12-31

    The aim of this paper was to assess whether the ambulatory (outpatient) therapy with {sup 186}Re-HEDP and {sup 153}Sm-EDTMP is possible in the Czech Republic. Physical characteristics, administered activity, biokinetics of radiopharmaceuticals, radiation protection characteristics, irradiation of patients relatives as well as comparison with limits for rhenium-186 and samarium-153 radiopharmaceuticals are given. The outpatient administration of {sup 186}Re-HEDP and {sup 153}Sm-EDTMP with the subsequent keeping the patient for 6 hours in a department of nuclear medicine appears to be in compliance with regulations proposed in the Czech Republic as well as ICRP Recommendations. (J.K.) 1 tab., 12 refs.

  1. The adsorption of 117Snm(IV)-EDTMP on collagen

    International Nuclear Information System (INIS)

    Yang Yuqing; Luo Shunzhong; Pu Manfei; Bing Wenzeng; He Jiaheng; Wang Guanquan

    2002-01-01

    The adsorption and desorption characteristics of 117 Sn m (IV)-EDTMP on collage are studied, and compared with that on HA. The results show that the effects of pH and temperature on adsorption of 117 Sn m (IV)-EDTMP on collagen are similar to those on HA, and that the adsorption equilibrium and adsorption model of 117 Sn m (IV)-EDTMP on collagen are completely different from those on HA; 117 Sm m -EDTMP absorbed on collagen are extremely stable and almost could not be desorbed with normal saline or EDTMP

  2. Random comparison study of the clinical response to 153Sm-EDTMP 1.0 mCi/kg and 1.5 mCi/kg

    International Nuclear Information System (INIS)

    Pan, Z.; Zhu, S.

    2001-01-01

    Sixty-seven patient with painful bone metastases were randomized to two groups. Group 1 (n=34) received 1.0 mCi/kg of 153 Sm-EDTMP and group II (n=33) received 1.5 mCi/kg. All of them met inclusion criteria and there was no significantly difference between the basic conditions of two groups. After receiving 153 Sm-EDTMP intravenously, all patients were kept in close follow-up weekly with blood counting, physician visiting and collecting patient's self-filling-in diary including pain score, Karnofsky performance scale and analgesic consumption. The follow-up duration was six weeks. The final overall condition assessed by physician were graded into no change (including worse), slight relief, significant relief and complete relief. Only significant relief and complete relief were considered as effectiveness for pain relief. Haematological toxicity grade was evaluated based on the nadir of WBC ad PLT counts. The results indicated that the higher dosage group had a higher effectiveness rate (75.76%) compared to the lower dosage group (67.65%), but without statistic significance (x 2 =0.5365, 0.25 153 Sm-EDTMP could be used for those patients with better haematological function and 1.0 mCi/kg used for those patients with poorer haematological function. (author)

  3. Evaluation of samarium-153 and holmium-166-EDTMP in the normal baboon model

    Energy Technology Data Exchange (ETDEWEB)

    Louw, W.K.A.; Dormehl, I.C.; Rensburg, A.J. van; Hugo, N.; Alberts, A.S.; Forsyth, O.E.; Beverley, G.; Sweetlove, M.A.; Marais, J.; Loetter, M.G.; Aswegen, A. van

    1996-11-01

    Bone-seeking radiopharmaceuticals such as ethylenediaminetetramethylene phosphonate (EDTMP) complexes of samarium-153 and holmium-166 are receiving considerable attention for therapeutic treatment of bone metastases. In this study, using the baboon experimental model, multicompartmental analysis revealed that with regard to pharmacokinetics, biodistribution, and skeletal localisation, {sup 166}Ho-EDTMP was significantly inferior to {sup 153}Sm-EDTMP and {sup 99m}Tc-MDP. A more suitable {sup 166}Ho-bone-seeking agent should thus be sought for closer similarity to {sup 153}Sm-EDTMP to exploit fully the therapeutic potential of its shorter half-life and more energetic beta radiation.

  4. Improving the dose-myelotoxicity correlation in radiometabolic therapy of bone metastases with {sup 153}Sm-EDTMP

    Energy Technology Data Exchange (ETDEWEB)

    Pacilio, Massimiliano; Basile, Chiara [Azienda Ospedaliera San Camillo Forlanini, Rome (Italy). Dept. of Medical Physics; Ventroni, Guido; Mango, Lucio [Azienda Ospedaliera San Camillo Forlanini, Rome (Italy). Dept. of Nuclear Medicine; Ialongo, Pasquale [Azienda Ospedaliera San Camillo Forlanini, Rome (Italy). Dept. of Radiology; Becci, Domenico [University of Rome, Health Physics Postgraduate School, Rome (Italy)

    2014-02-15

    {sup 153}Sm-ethylene diamine tetramethylene phosphonic acid ({sup 153}Sm-EDTMP) is widely used to palliate pain from bone metastases, and is being studied for combination therapy beyond palliation. Conceptually, red marrow (RM) dosimetry allows myelotoxicity to be predicted, but the correlation is poor due to dosimetric uncertainty, individual sensitivity and biological effects from previous treatments. According to EANM guidelines, basic dosimetric procedures have been studied to improve the correlation between dosimetry and myelotoxicity in {sup 153}Sm-EDTMP therapy. RM dosimetry for 33 treatments of bone metastases from breast, prostate and lung tumours was performed prospectively (with {sup 99m}Tc-MDP) and retrospectively, acquiring whole-body scans early and late after injection. The {sup 153}Sm-EDTMP activity was calculated by prospective dosimetry based on measured skeletal uptake and full physical retention, with the RM absorbed dose not exceeding 3.8 Gy. Patient-specific RM mass was evaluated by scaling in terms of body weight (BW), lean body mass (LBM) and trabecular volume (TV) estimated from CT scans of the L2-L4 vertebrae. Correlations with toxicity were determined in a selected subgroup of 27 patients, in which a better correlation between dosimetry and myelotoxicity was expected. Skeletal uptakes of {sup 99m}Tc and {sup 153}Sm (Tc{sub %} and Sm{sub %}) were well correlated. The median Sm{sub %} was higher in prostate cancer (75.3 %) than in lung (60.5 %, p = 0.005) or breast (60.8 %, p = 0.008). PLT and WBC nadirs were not correlated with administered activity, but were weakly correlated with uncorrected RM absorbed doses, and the correlation improved after rescaling in terms of BW, LBM and TV. Most patients showed transient toxicity (grade 1-3), which completely and spontaneously recovered over a few days. Using TV, RM absorbed dose was in the range 2-5 Gy, with a median of 312 cGy for PLT in patients with toxicity and 247 cGy in those with no

  5. The Level of Europium-154 Contaminating Samarium-153-EDTMP Activates the Radiation Alarm System at the US Homeland Security Checkpoints

    Directory of Open Access Journals (Sweden)

    Mohammed Najeeb Al Hallak

    2009-08-01

    Full Text Available 153Sm-EDTMP is a radiopharmaceutical composed of EDTMP (ethylenediamine-tetramethylenephosphonate and Samarium-153 [1]. 153Sm-EDTMP has an affinity for skeletal tissue and concentrates in areas with increased bone turnover; thus, it is successfully used in relieving pain related to diffuse bone metastases [1]. The manufacturing process of 153Sm-EDTMP leads to contamination with 154Eu (Europium-154 [2]. A previous study only alluded to the retention of 154Eu in the bones after receiving treatment with 153Sm-EDTMP [2]. Activation of the alarm at security checkpoints after 153Sm-EDTMP therapy has not been previously reported. Two out of 15 patients who received 153Sm-EDTMP at Roger Maris Cancer Center (Fargo, N. Dak., USA activated the radiation activity sensors while passing through checkpoints; one at a US airport and the other while crossing theAmerican-Canadian border. We assume that the 154Eu which remained in the patients’ bones activated the sensors. Methods: In order to investigate this hypothesis, we obtained the consent from 3 of our 15 patients who received 153Sm-EDTMP within the previous 4 months to 2 years, including the patient who had activated the radiation alarm at the airport. The patients were scanned with a handheld detector and a gamma camera for energies from 511 keV to 1.3 MeV. Results: All three patients exhibited identical spectral images, and further analysis showed that the observed spectra are the result of 154Eu emissions. Conclusion: Depending on the detection thresholds and windows used by local and federal authorities, the remaining activity of 154Eu retained in patients who received 153Sm-EDTMP could be sufficient enough to increase the count rates above background levels and activate the sensors. At Roger Maris Cancer Center, patients are now informed of the potential consequences of 153Sm-EDTMP therapy prior to initiating treatment. In addition, patients treated with 153Sm-EDTMP at Roger Maris Cancer Center

  6. 89Sr and 153Sm-EDTMP therapy of disseminated skeletal metastasis

    International Nuclear Information System (INIS)

    Zhang Junning; Hong Chengjiao; Zhu Shoupeng

    2001-01-01

    A retrospective analysis was performed on 72 patients with disseminated skeletal metastasis to evaluate the effect of strontium-89 or samarium-153 EDTMP therapy. There existed 87.88% of clinical response, 12.12% of no response in the group treated with strontium-89 as compared with 90.24% of clinical response, 9.76% no response in one treated with samarium-153 EDTMP; and there were no correlation between the treatment results and the amounts of isotopes administrated. The results suggest that strontium-89 or samarium-153 EDTMP therapy is a method of first choice in the palliative treatment for disseminated skeletal metastasis

  7. Preparation and quality control of {sup 153}Sm radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Swasono, R Tamat; Widyastuti, W; Purwadi, B; Laksmi, I [Radioisotope Production Center - BATAN, Jakarta (Indonesia)

    1998-10-01

    The paper summarizes the preparation and quality control of {sup 153}Sm-EDTMP and three {sup 153}Sm-radiosynovectomy agents. Natural and enriched Sm{sub 2}O{sub 3} (98.7% {sup 152}Sm) irradiated in RSG-GAS 30 MW reactor yielded pure and high specific activity {sup 153}Sm. Labeling of EDTMP with {sup 153}Sm was carried out by mixing {sup 153}SmCl{sub 3} solution of pH 4.0 to an EDTMP solution at room temperature then pH adjustment to 8. The {sup 153}Sm-EDTMP complex was separated from the free {sup 153}Sm{sup +3} on a Chelex 100 column. Radiochemical purity was determined by thin layer chromatography using Cellulose sheets and pyridine: ethanol: water (1: 2: 4) mixture as solvent. The {sup 153}Sm-EDTMP has been shown to be stable for two weeks. Three particulate preparations of {sup 153}Sm used for the irradiation of chronic synovitis have been studied. They are hydroxyapatite particles, human serum albumin microspheres and ferric hydroxide macroaggregates. The {sup 153}Sm-ferric hydroxide macroaggregates were prepared in a single step by coprecipitation of {sup 153}Sm in the formation of Fe(OH){sub 3}. Preparation of {sup 153}Sm-labelled hydroxyapatite particles and {sup 153}Sm-labelled albumin microspheres were carried out by {sup 153}Sm labelling of previously prepared particles. Radiolabelling efficiency were greater than 95% for hydroxyapatite particles and macroaggregates and was lower than 20% for albumin microspheres. The particle sizes were inspected using an optical microscope with a haemocytometer and micrometric ocular. (author)

  8. Synthesis and bio-evaluation of nano-hydroxyapatite trapped by 153Sm

    International Nuclear Information System (INIS)

    Bing Wenzeng; Luo Shunzhong; Wen Guanghua; Jiang Shubin; Xiong Xiaoling; Liu Guoping

    2006-03-01

    After nanoHA was synthesized, 153 Sm-EDTMP-nanoHA and 153 Sm-citrate-nanoHA were prepared and proved stable in vitro. ECT images of New Zealand rabbits injected with 153 Sm-EDTMP-nanoHA had better contrast, skeletal figure visible, liver and spleen clear. The images of 153 Sm-citrate-nanoHA showed a similar results but kidney invisible, which meant 153 Sm-citrate-nanoHA showed a similar results but kidney invisible, which meant 153 Sm-citrate-nanoHA was mainly excreted through liver and gall. 153 Sm-EDTMP-nanoHA's half effective inhibition concentrations to SMMC-7721 and MCF-7 cells were 1.98 g/L and 0.075 g/L respectively and 153 Sm-citrate-nanoHA's were 1.89 g/L and 0.094 g/L proportionally. 153 Sm-EDTMP-nanoHA and 153 Sm-citrate-nanoHA were worthy of a further research because their half effective inhibition concentrations were much lower than ones of the single nanoHA. (authors)

  9. Lutetium-177-EDTMP for pain palliation in bone metastases

    International Nuclear Information System (INIS)

    Rutty Sola, Gisela A.; Arguelles, Maria G.; Bottazzini, Debora L.; Furnari, Juan C.; Vera Ruiz, H.

    1999-01-01

    Experiences with the new palliative agent Lu-177 EDTMP are summarized. The production of primary 177 Lu by the 176 Lu(n,γ) 177 Lu reaction and the synthesis of the radioactive complex are described as well as the procedures used for the control of the radionuclidic and the radiochemical purity. The stability of the compound has been also studied. The in vivo essays with rats and the use of the radiopharmaceutical, after a careful dose evaluation, in a patient with bone metastases from a breast cancer, show that the behaviour of Lu-177 EDTMP is similar to that of the analogue Sm-153 EDTMP. (author)

  10. Study of toxicity of Samarium-153-EDTMP in the treatment of painful skeletal metastasis. Final report for the period 15 December 1996 - 14 December 1997

    International Nuclear Information System (INIS)

    Zhu Shoupeng

    1998-02-01

    Favourable characteristics of Sm-153 EDTMP make it an effective agent for use in the palliative treatment of metastatic bone pain. It has also been postulated that Sm-153 might have some tumoricidal effect. But until today its mechanism of action in the treatment of skeletal metastasis is not known. This experimental study has been designed to study the cellular and molecular changes occurring in the bone tumour cells (osteosarcoma of femur of wister rats) following irradiation with different doses of Sm-153 EDTMP. Experimental osteosarcorna tumour cells were harvested and treated with Sm-153 EDTMP over different periods of time ranging from 1-24 hours. Electron microscope, fluorescence microscope, MTI assay and 3 HTdR release assay studies were conducted to observe for effects of radiation. Sm-153 EDTMP irradiation of bone tumour cells resulted in significant nuclear fragmentation, margination of condensed chromatin, marked pyknosis and increased formation of membrane bounded apoptotic bodies formation. The quantification analysis of fragmented DNA for bone tumour cells induced by Sm-153 EDTMP showed that the DNA fragmentation was enhanced with prolongation of irradiation time. The inhibition rate of proliferation of bone tumour cells as well as DNA fragmentation in bone tumour cells after irradiation with Sm-153 EDTMP increased significantly and progressively with prolongation of irradiation time, reaching levels of 63% and 78% respectively by 24 hours. (author)

  11. Biodistribution study of 153Sm-EDTMP produced by irradiation of natural and enriched Samarium, in rats

    International Nuclear Information System (INIS)

    Meftahi, M.; Bahrami Samani, A.; Babaei, M. H.; Shamsaei Zafarghandi, M.; Ghannadi Maragheh, M.

    2010-01-01

    ''1 53 Sm-EDTMP is one of the well known radiopharmaceuticals for pain palliation of bone metastases. Despite that, it is used just in a few countries. It is due to some reasons like being costly enriched samarium that usually used as target for irradiation and short half-life of 153 Sm. In this investigation, certain amounts of radiopharmaceuticals prepared by irradiation of enriched and natural samarium were injected to some normal rats. Then, the rodents were sacrificed and some of their organs were removed. All of the mentioned stages were performed in order to consider the possibility of exploiting natural samarium instead of enriched samarium by study of biodistribution of both radiopharmaceuticals in various organs especially in bone as the target tissue. At the end, the acceptable results were obtained using natural samarium in comparison with the enriched samarium from the point of view of the biodistribution studies.

  12. Safety and feasibility of percutaneous vertebroplasty with radioactive {sup 153}Sm PMMA in an animal model

    Energy Technology Data Exchange (ETDEWEB)

    Lu Jun [Department of Radiotherapy, Xijing Hospital, Fourth Military Medical University, 15 West Changle Road, Xi' an 710032, Shaanxi Province (China); Deng Jinglan, E-mail: dengjinglan@gmail.com [Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, 15 West Changle Road, Xi' an 710032, Shaanxi Province (China); Zhao Haitao [Department of Radiology, Xijing Hospital, Fourth Military Medical University, 15 West Changle Road, Xi' an 710032, Shaanxi Province (China); Shi Mei [Department of Radiotherapy, Xijing Hospital, Fourth Military Medical University, 15 West Changle Road, Xi' an 710032, Shaanxi Province (China); Wang Jing [Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, 15 West Changle Road, Xi' an 710032, Shaanxi Province (China); Zhao Lina [Department of Radiotherapy, Xijing Hospital, Fourth Military Medical University, 15 West Changle Road, Xi' an 710032, Shaanxi Province (China)

    2011-05-15

    Purpose: We investigated the safety and feasibility of the combination of samarium-153-ethylenediamine tetramethylene phosphonate ({sup 153}Sm-EDTMP)-incorporated bone cement (BC) with percutaneous vertebroplasty (PVP) in dogs. Methods and materials: {sup 153}Sm-EDTMP-incorporated BC was prepared by combining solid {sup 153}Sm-EDTMP and polymethylmethacrylate (PMMA) immediately before PVP. It was then injected into the vertebrae of four healthy mongrel dogs (two males and two females) by PVP under CT guidance. Each dog was subjected to five PVP sessions at a {sup 153}Sm-EDTMP dose of 30-70 mCi. The suppressive effect of local injection of {sup 153}Sm-EDTMP on the hematopoietic system was evaluated through counting of peripheral blood cells. Distribution of {sup 153}Sm-EDTMP-incorporated BC and the status of tissues adjacent to injected vertebrae were evaluated with SPECT, CT and MRI. Histopathology was carried out to assess the influence of PVP on the vertebra and adjacent tissues at the microscopic level. Results: PVP was done successfully, and all dogs exhibited normal behavior and stable physical signs after procedures. {sup 153}Sm-EDTMP-incorporated BC was concentrated mainly in target vertebrae, and the peripheral blood cells remained within normal range. The spinal cord and tissues around BC did not exhibit signs of injury even when the dosage of {sup 153}Sm-EDTMP increased from 30 mCi to 70 mCi. Conclusion: A dose lower than 70 mCi of {sup 153}Sm is safe when it was injected into vertebrae. {sup 153}Sm-EDTMP-incorporated BC did not influence the effect of PVP. This means might strengthen anti-tumor activity locally for vertebra with osseous metastasis without damaging adjacent tissues.

  13. Urine management after treatment with ''153 Sm-EDTMP (QUADRAMET)

    International Nuclear Information System (INIS)

    Delgado, A.; Diaz, J. P.; Carrasco, J. L.; Jimenez-Hoyuela, J. M.; Rebollo, A. C.; Martinez del Valle, M. D.; Ortega, S. J.

    2004-01-01

    The main purpose was to establish and to evaluate a new protocol of individualized treatment of patient urine after ''153 Sm-EDTMP injection, with a more efficient management of the wastes. Excreted urine was collected in an appropriate container form which, previous to sealing it, an aliquot of 10 ml was obtained. Experimental half-life (t1/2) of the isotope was then determined by measuring the activity at different times, besides the minimum time necessary for disposing of the radioactive wastes as regular trash. The measured half-life adjusted well to the theoretical value of the isotope. The time of considered storage oscillated between 19 and 26 days, based on the activity excreted by each patient. The main idea is the consideration of the set container-urine as solid waste: the evaluation of the minimum storage time necessary to its elimination is made in terms of legal limitation of specific activity by mass unit. The immediate advantages ares: the elimination of disagreeable scents by the storage of urine, it is not necessary a liquid waste disposal to eliminate it, and a more accurate knowledge of the specific activity at the moment of the elimination (dilution factor is not used). (Author) 10 refs

  14. {sup 89}Sr and {sup 153}Sm-EDTMP therapy of disseminated skeletal metastasis

    Energy Technology Data Exchange (ETDEWEB)

    Junning, Zhang; Chengjiao, Hong; Shoupeng, Zhu [Suzhou Univ., Suzhou (China)

    2001-07-01

    A retrospective analysis was performed on 72 patients with disseminated skeletal metastasis to evaluate the effect of strontium-89 or samarium-153 EDTMP therapy. There existed 87.88% of clinical response, 12.12% of no response in the group treated with strontium-89 as compared with 90.24% of clinical response, 9.76% no response in one treated with samarium-153 EDTMP; and there were no correlation between the treatment results and the amounts of isotopes administrated. The results suggest that strontium-89 or samarium-153 EDTMP therapy is a method of first choice in the palliative treatment for disseminated skeletal metastasis.

  15. Therapy for bone pain palliation in skeletal metastases with Samarium -153 EDTMP (Indonesian experience)

    International Nuclear Information System (INIS)

    Purnomo, E.

    2007-01-01

    Full text: Radiopharmaceutical therapy may be used for the treatment of cases with painful skeletal metastases. We evaluate and want to share an experience with application and efficacy of Sm-153 EDTMP in palliative painful bone metastases therapy. Our aim was to determine the efficacy and toxicity of single-dose Sm- 153 EDTMP as a palliative treatment for painful skeletal metastases. Material and methods: we selected 18 patients (9 male, 9 female). The average age 35-65 years weight 40- 60 kg; with metastatic bone confirmed with bone scan examination. 6 with breast cancer, 5 with nasopharyngeal cancer, 5 with prostatic cancer, 2 with lung cancer were treated with 30 mCi ( 1110 MBq) Sm-153 EDTMP. All showed extensive metastatic bone disease. The patients were given intravenous injections of 30 mCi Sm-153 EDTMP, after reconditioning, hydration . We established intensity of pain, haematological parameters, scintigraphic, Karnofsky scale. Clinical assessment was performed one month later. Responses were classified in completed (good response), partial and absent taking into account symptoms and drugs reduction. The discontinuation or the reduction of analgesic drugs like opiate dosage was also considered as successful palliative results of the treatment. Result: pain relief was obtained in 16/18 patients, Sm-153 was effective in patients with reduced drug assumption. The response to Sm-153 was good in 14/18(77,7%) of the patients and partial in 3/18(16,6%) and no response in 1/18(0,5%). The application of Sm-153 in patients with painful disseminated bone metastases has a satisfactory pain alleviating effects. Sides effects were noted, decrease hemoglobin counts and white blood cell and platelets, which gradually returned to near normal after 6 weeks. Easy application and low cost and produced in own country are important factors. Conclusion: radiopharmaceutical therapy can be recommended because of the favorable palliation effect and the low cost of Sm-153, especially

  16. Improved conditions for labeling EDTMP with 188Re for bone pain palliation

    International Nuclear Information System (INIS)

    Faintuch, B.L.; Osso, J.A. Jr.; Muramoto, E.; Faintuch, S.

    2002-01-01

    Introduction: Ethilenediamine tetramethylene phosphonate (EDTMP) is a tetraphosphonate ligand which, when labeled with 188 Re, can be used for relief of metastatic bone pain. The preferential localization of phosphonate complexes in bone is attributed to their affinity for calcium, and tetraphosphonates may be equal or superior to diphosphonates in this regard. In the present study, it was aimed to determine optimal conditions for preparation of a kit of EDTMP to be labeled with 188 Re. Methods: EDTMP was dissolved in NaOH 1N, and alkalinity was reversed with HCl till pH 2, when SnCl 2 . 2H 2 0 and also ascorbic acid were introduced in the mixture, followed by Na 188 ReO 4 . The preparation was incubated in water bath for 30 minutes and after cooling radiochemical purity was assessed. Optimization of the process consisted in varying the values of EDTMP mass (20, 30, 40 mg) SnCl 2 .2H 2 0 concentration (0.5, 1.0, 2.0 and 3.0 mg/mL), and reaction time (15 and 30 minutes). Radiochemical purity and stability were ascertained in vitro and also in Swiss mice. Bone/muscle uptake ratio was calculated from %ID/g of these organs. Results: The best 188 Re-EDTMP complex was obtained with 40 mg of the ligand and 2 mg/mL of stannous chloride heated during 15 minutes, and the product was radiochemically stable during 24 hours. Kidney and bone uptake were very significant (respectively 4.5 ± 0.5% and 3.1 ± 0.3 %ID/g). Bone/muscle ratio observed four hours post-injection was also very adequate (28.5). Conclusions: A stable and biologically useful complex of 188 Re-EDTMP can be prepared with high concentration of EDTMP and considerable uptake by bone. It compares favorably with 153 Sm-EDTMP, as 188 Re has more advantageous radioisotopic properties than 153 Sm, and it can be recommended for further studies in conditions of painful bone metastases

  17. Biological evaluation of 153Sm-ethylenediaminetetra methylene phosphonate (EDTMP)

    International Nuclear Information System (INIS)

    Ranganatha, D.K.; Lal, Ramji

    1997-01-01

    Samarium-153 EDTMP has been studied in rats to establish bone localisation in normal bone tissue and the uptake in the soft tissue. Biodistribution results were highly promising with >3% of the injected dose localizing in the femurs and 15 days. (author). 4 refs., 2 tabs

  18. Estudio termodinámico de una planta de ciclo combinado con turbina de gas y pre-diseño del HRSG

    OpenAIRE

    Martín Díaz, Carlos Daniel

    2015-01-01

    Dentro del gran alcance que se puede dar a los estudios de plantas de ciclos combinados, el presente estudio se centra en analizar un ciclo combinado convencional con turbina de gas, y en condiciones de diseño. En concreto, se trata de realizar un análisis termodinámico de un ciclo combinado en configuración monoeje 1x1 con recalentamiento y tres niveles de presión, con turbina de gas refrigerada por sistema vapor-aire y posteriormente un análisis de transferencia de calor en los intercamb...

  19. Estudio termoeconómico de diferentes configuraciones de ciclo combinado integrado con una planta solar

    Directory of Open Access Journals (Sweden)

    María Dolores Durán García

    2014-01-01

    Full Text Available Se presenta el análisis termoeconómico de una planta de ciclo combinado integrada con una planta solar de canal parabólico, considerada como una sección de la caldera de recuperación de calor, con el objetivo de conseguir un diseño óptimo al determinar los parámetros de diseño optimizados para ambos sistemas. Se aplica una metodología empleada en trabajos previos para la optimización de ciclos combinados, pero ahora con una planta solar. Como resultado, a partir de un análisis de sensibilidad, se obtiene el desempeño de varias configuraciones bajo diferentes condiciones de radiación solar.

  20. The importance of BMI in dosimetry of 153Sm-EDTMP bone pain palliation therapy: A Monte Carlo study

    International Nuclear Information System (INIS)

    Fallahpoor, Maryam; Abbasi, Mehrshad; Asghar Parach, Ali; Kalantari, Faraz

    2017-01-01

    Using digital phantoms as an atlas compared to acquiring CT data for internal radionuclide dosimetry decreases patient overall radiation dose and reduces the required analysis effort and time for organ segmentation. The drawback is that the phantom may not match exactly with the patient. We assessed the effect of varying BMIs on dosimetry results for a bone pain palliation agent, 153 Sm-EDTMP. The simulation was done using the GATE Monte Carlo code. Female XCAT phantoms with the following different BMIs were employed: 18.6, 20.8, 22.1, 26.8, 30.3 and 34.7 kg/m 2 . S-factors (mGy/MBq.s) and SAFs (kg −1 ) were calculated for the dosimetry of the radiation from major source organs including spine, ribs, kidney and bladder into different target organs as well as whole body dosimetry from spine. The differences in dose estimates from different phantoms compared to those from the phantom with BMI of 26.8 kg/m 2 as the reference, were calculated for both gamma and beta radiations. The relative differences (RD) of the S-factors or SAFs from the values of reference phantom were calculated. RDs greater than 10% and 100% were frequent in radiations to organs for photon and beta particles, respectively. The relative differences in whole body SAFs from the reference phantom were 15.4%, 7%, 4.2%, −9.8% and −1.4% for BMIs of 18.6, 20.8, 22.1, 30.3 and 34.7 kg/m 2 , respectively. The differences in whole body S-factors for the phantoms with BMIs of 18.6, 20.8, 22.1, 30.3 and 34.7 kg/m 2 were 39.5%, 19.4%, 8.8%, −7.9% and −4.3%, respectively. The dosimetry of the gamma photons and beta particles changes substantially with the use of phantoms with different BMIs. The change in S-factors is important for dose calculation and can change the prescribed therapeutic dose of 153 Sm-EDTMP. Thus a phantom with BMI better matched to the patient is suggested for therapeutic purposes where dose estimates closer to those in the actual patient are required. - Highlights: • Internal

  1. Samarium-153-EDTMP in the metastatic bone pain treatment

    International Nuclear Information System (INIS)

    Lins Filho, M.L.M.; Santos, A.O.; Nappi, A.P.B.; Meirelles, M.B.; Arouca, P.T.; Ramos, C.D.; Etchebehere, E.C.S.C.; Teixeira, L.C.; Netto Junior, N.R.; D'Ancona Cal; Camargo, E.E.

    1997-01-01

    Full text: Bone metastasis is the most reason of pain in prostate and mammary cancer patients. The Samarium-153-EDTMP has been showed as an alternative to the treatment of the metastasis bone pain. With the objective to evaluate the use of the Sm-153-EDTMP as a systemic therapy for the metastasis bone pain, 30 patients (19 male, 11 female, average age of 64,5 years) were studied. 19 patients with prostate cancer and 11 with mammary cancer. All the patients presented previous bone scintiscanning with multiple metastasis; interruption of the chemotherapy or radiotherapy for two or more weeks and leukocyte count higher than 2,000 leukocytes/mm 3 and platelets higher than 80,000/mm 3 . The patients were classified previously to the radioisotope therapy, as far the intensity of the pain in a scale from 0 to 10 is concerned. All the patients received 37 MBq/kg (1m Ci/kg) of weight of Sm-153-EDTMP by venous via. The evaluation 6 weeks after the therapy showed complete or partial pain relief in 22 patients (73,3%). Complete or partial pain relief has been obtained in 91,0% (10 in 11) of the patients with mammary cancer and in 62,2% (12 in 19) of the patients with prostate cancer. Transitory leukopenia (lower than 2,000 leukocytes/mm 3 ) and platelet count (lower than 80,000/mm 3 ) occurred in 33,3% of the patients. 8 patients (26,7%) did not responded to the therapy. The therapy with Samarium-153-EDTMP is a simple, safe and efficient method in the treatment of the bone pain caused by metastasis

  2. Chilean experience in production of therapeutic radiopharmaceuticals labelled with 153Sm and 166Ho

    International Nuclear Information System (INIS)

    Chandia, M.; Gil, M.G.; Tomicic, M.; Araya, G.; Olea, E.; Chong, G.

    1998-01-01

    153 Samarium ( 153 Sm) and 166 Holmium ( 166 Ho) were produced at the Nuclear Center of La Reina Research Reactor, Chilean Nuclear Energy Commission. 153 Sm-EDTMP (Ethylenediaminetetramethylene Phosphonate) used for clinical trial of therapy for painful skeletal metastases and labeled particles such as 166 Ho-FHMA (ferric hydroxide macroagregattes) and 153 Sm-HAP (hydroxiapatite particles) used for radiation synevectomy, were labeled. Radionuclide purity of both radionuclides was analyzed by gamma spectrometry using a multichannel gamma spectrometer. Radiochemical labeled reaction parameters of 153 Sm-EDTMP such as: Sm/EDTMP molar ratio, 153 Sm specific activity, labeled pH and temperature, were determined in order to get high radiolabeling yields. Radiochemical Quality Controls of 153 Sm-EDTMP using different chromatographic systems were carried out in order to determine labeling yields. Bodistribution studies were achieved in mice by dissection of animals and by autoradiography of histological slices in rats, after 2h post injection. 153 Sm-HAP and 166 Ho-FHMA labeled particles were prepared using the methods described. Radiochemical purity, in case of radiolabeled particles was carried out by centrifugation, measuring activity in the supernatant and in particles pellet. Physical parameters, such as particle size and range of the radiopharmaceuticals based on particles labeling were evaluated in order to determine the ideal conditions to obtain particles size range between 10 - 40μ. In vitro labeling stability for over seven days and wash out activity by incubation in human synovial fluid after 6 and 24h post labeling, was also studied. 153 Sm-EDTMP was easily labeled with a Radiochemical purity over 99.5% and stable for over 7 days. Biodistribution studies in mice give more than 50% of ID uptake in bone and less than 0,1% in liver this was correlated by autoradiographic image. 153 Sm-HAP and 166 Ho-FHMA were also labeling obtaining radiochemical purity over 95

  3. High-activity samarium-153-EDTMP therapy followed by autologous peripheral blood stem cell support in unresectable osteosarcoma

    International Nuclear Information System (INIS)

    Franzius, Ch.; Eckardt, J.; Sciuk, J.; Schober, O.; Bielack, S.; Flege, S.; Juergens, H.

    2001-01-01

    Purpose: Despite highly efficacious chemotherapy, patients with osteosarcomas still have a poor prognosis if adequate surgical control cannot be obtained. These patients may benefit from therapy with radiolabeled phosphonates. Patients and Methods: Six patients (three male, three female; seven to 41 years) with unresectable primary osteosarcoma (n = 3) or unresectable recurrent sites of osteosarcomas (n = 3) were treated with high-activity of Sm-153-EDTMP (150 MBq/kg BW). In all patients autologous peripheral blood stem cells had been collected before Sm-153-EDTMP therapy. Results: No immediate adverse reactions were observed in the patients. In one patient bone pain increased during the first 48 hrs after therapy. Three patients received pain relief. Autologous peripheral blood stem cell reinfusion was performed on day +12 to +27 in all patients to overcome potentially irreversible damage to the hematopoietic stem cells. In three patient external radiotherapy of the primary tumor site was performed after Sm-153-EDTMP therapy and in two of them polychemotherapy was continued. Thirty-six months later one of these patients is still free of progression. Two further patients are still alive. However, they have developed new metastases. The three patients who had no accompanying external radiotherapy, all died of disease progression five to 20 months after therapy. Conclusion: These preliminary results show that high-dose Sm-153-EDTMP therapy is feasible and warrants further evaluation of efficacy. The combination with external radiation and polychemotherapy seems to be most promising. Although osteosarcoma is believed to be relatively radioresistant, the total focal dose achieved may delay local progression or even achieve permanent local tumor control in patients with surgically inaccessible primary or relapsing tumors. (orig.)

  4. sup 8 sup 9 Sr and sup 1 sup 5 sup 3 Sm-EDTMP therapy of disseminated skeletal metastasis

    CERN Document Server

    Zhang Jun Ning; Zhu Shou Peng

    2001-01-01

    A retrospective analysis was performed on 72 patients with disseminated skeletal metastasis to evaluate the effect of strontium-89 or samarium-153 EDTMP therapy. There existed 87.88% of clinical response, 12.12% of no response in the group treated with strontium-89 as compared with 90.24% of clinical response, 9.76% no response in one treated with samarium-153 EDTMP; and there were no correlation between the treatment results and the amounts of isotopes administrated. The results suggest that strontium-89 or samarium-153 EDTMP therapy is a method of first choice in the palliative treatment for disseminated skeletal metastasis

  5. Efectos del ejercicio aeróbico interválico, combinado con entrenamiento de fuerza y de la restricción calórica, sobre la composición corporal de ratas obesas

    OpenAIRE

    I. Coll-Risco; D. Camiletti-Moirón; D.J. Tirado; E. Nebot; A. Andrade; R. Martínez; G. Kapravelou; J.M. Porres; P. Aranda; V.A. Aparicio

    2017-01-01

    Objetivo: Investigar los efectos de un programa de ejercicio aeróbico interválico, combinado con entrenamiento de fuerza, y de la restricción calórica, sobre el peso y la composición corporal de ratas genéticamente obesas. Método: Un total de 32 ratas genéticamente obesas fueron divididas aleatoriamente en dos grupos (n = 16) con o sin ejercicio aeróbico interválico combinado con entrenamiento de fuerza. A su vez, cada grupo, con o sin ejercicio aeróbico interválico combinado con entrenami...

  6. Efectos del ejercicio aeróbico interválico, combinado con entrenamiento de fuerza y de la restricción calórica, sobre la composición corporal de ratas obesas

    OpenAIRE

    Coll-Risco, I.; Camiletti-Moirón, D.; Tirado, D.J.; Nebot, E.; Andrade, A.; Martínez, R.; Kapravelou, G.; Porres, J.M.; Aranda, P.; Aparicio, V.A.

    2017-01-01

    Resumen Objetivo: Investigar los efectos de un programa de ejercicio aeróbico interválico, combinado con entrenamiento de fuerza, y de la restricción calórica, sobre el peso y la composición corporal de ratas genéticamente obesas. Método: Un total de 32 ratas genéticamente obesas fueron divididas aleatoriamente en dos grupos (n = 16) con o sin ejercicio aeróbico interválico combinado con entrenamiento de fuerza. A su vez, cada grupo, con o sin ejercicio aeróbico interválico combinado con en...

  7. Apparent partition coefficient in octanol-water and binding percentage to BSA of 153Sm(113,117Snm) complexes

    International Nuclear Information System (INIS)

    Yang Yuqing; Luo Shunzhong; Wang Guanquan; He Jiaheng; Bing Wenzeng; Pu Manfei; Wei Hongyuan; Wang Wenjin

    2004-01-01

    Apparent partition coefficient in octanol-water and binding percentage to BSA of 153 Sm-NTMP, 153 Sm-HEDTMP, 153 Sm-DCTMP, 153 Sm-EDTMP, 153 Sm-DTPMP, 113,117 Sn m -EDTMP, 113,117 Sn m -HEDTMP, 113,117 Sn m -DTPMP are measured. The results show that there is a linear relationship between the relative magnitude of the apparent partition coefficient in octanol-water and the relative magnitude of the binding percentage to BSA of these 153 Sm( 113,117 Sn m ) complexes. This linear relationship provides a new method for determination of the apparent partition coefficient in octanol-water of 153 Sm( 113,117 Sn m ) complexes of this kind. This linear relationship also implicates that hydrophobic force plays an important role in the binding of 153 Sm( 113,117 Sn m ) complexes to BSA

  8. An electrochemical approach for removal of radionuclidic contaminants of Eu from 153Sm for effective use in metastatic bone pain palliation.

    Science.gov (United States)

    Chakravarty, Rubel; Chakraborty, Sudipta; Khan, Mohammed Sahiralam; Ram, Ramu; Sarma, Haladhar Dev; Dash, Ashutosh

    2018-03-01

    Thermal neutron activation of 152 Sm [ 152 Sm(n,γ) 153 Sm] using natural or isotopically enriched (by 152 Sm) samarium target is the established route for production of 153 Sm used for preparation of 153 Sm-EDTMP for pain palliation in cancer patients with disseminated bone metastases. However, some long-lived radionuclidic contaminants of Eu, such as, 154 Eu (t ½ =8.6y) are also produced during the target activation process. This leads to detectable amount of Eu radionuclidic contaminants in patients' skeleton even years after administration with therapeutic doses of 153 Sm-EDTMP. Further, the presence of such contaminants in 153 Sm raises concerns related to radioactive waste management. The aim of the present study was to develop and demonstrate a viable method for large-scale purification of 153 Sm from radionuclidic contaminants of Eu. A radiochemical separation procedure adopting electroamalgamation approach has been critically evaluated. The influence of different experimental parameters for the quantitative removal radionuclidic contaminants of Eu from 153 Sm was investigated and optimized. The effectiveness of the method was demonstrated by purification of ~37 GBq of 153 Sm in several batches. As a proof of concept, 153 Sm-EDTMP was administered in normal Wistar rats and ex vivo γ-spectrometry of bone samples were carried out. After carrying out the electrolysis under the optimized conditions, the radionuclidic contaminants of Eu could not be detected in purified 153 Sm solution by γ-spectrometry. The overall yield of 153 Sm obtained after the purification process was >85%. The reliability of this approach was amply demonstrated in several batches, wherein the performance remained consistent. Ex vivo γ-spectrometry of bone samples of Wistar rats administered with 153 Sm-EDTMP (prepared using electrochemically purified 153 Sm) did not show photo peaks corresponding to radionuclidic contaminants of Eu. A viable electrochemical strategy for the large

  9. Comparative study of skeletal dosimetry methods in therapeutic schemes with Re186 HEDP and Sm153 EDTMP

    International Nuclear Information System (INIS)

    Papanikolos, G.; Lyra, M.; Kontogeorgakos, D.; Jordanou, J.; Vlahos, L.; Limouris, G.

    2005-01-01

    Full text: Optimum therapeutic management of patients suffering from metastatic bone pain, requires accurate calculations concerning absorbed dose by metastatic lesions and other critical organs, such as red marrow. Mean absorbed dose, which is the current parameter used to predict the efficacy of the treatment, can either overestimate or underestimate, actual doses delivered in these organs/tissues of interest (TOIs). This study presents differences in dosimetric calculations derived utilizing parameters from different sources (MIRDOSE3, MIRD Pamphlet No 11 and S values published by Bouchet et al.), in therapeutic schemes with Re186HEDP and Sm153EDTMP. A set of planar scintigraphic images for 2 groups of patients (1 for Re 186 patients and the other for Sm153 patients) were obtained in the following sequence: 2 during the first 24h post injection (the last of which at 24h post injection) and 2 more from 24h 7d post injection. Processing of the obtained images utilizing ROI quantitative methods, previously calibrated with waterphantom measurements, determine residence times and radionuclide uptakes not only by TOIs but by specific skeletal sites as well. Dosimetric calculations were performed using MIRDOSE3 computer code, S values from MIRD Pamphlet No 11 and site specific Re 186 and Sm 153 S values for several source target combinations within trabecular and cortical bone, reported by Bouchet et al. (J Nucl Med 2000; 41:189 212), along with cumulative site specific activities derived from values obtained by image processing. Skeletal averaged Re 186 and Sm 153 S values were also used from the aforementioned study by Bouchet et al. Time activity curves for various skeletal sites were generated for both groups of patients. Absorbed dose distributions along with time dose rate curves were derived for both red marrow and different regions of the skeleton. Comparisons are made between these parameters and mean absorbed doses calculated using skeletal averaged S values

  10. Efficacy and toxicity of Samarium-153-EDTMP locally produced in the treatment of painful skeletal metastases

    International Nuclear Information System (INIS)

    Olea, E.; Quintana, J.C.; Nagel, J.; Arenas, L.; Tomicic, M.; Gil, M.C.; Araya, G.

    2001-01-01

    Samarium-153 emits medium-energy beta particles an a gamma photon with a physical half-life of 46,3 hours. When chelated to ethylenediaminetetramethylenephosphonic acid (EDTMP), it is remarkably stable in vitro and in vivo. In this study we administered randomly 0,5 and 1,0 mCi/Kg body weight (two groups), to 30 patients with painful metastatic bone cancer. Slight and spontaneously reversible myelotoxicity was observed. A bigger leukocyte and platelet suppression was obtained with 1,0 mCi/kg than 0,5 mCi/Kg dose. Pain palliation was obtained in 66% of the treated patients. Our preliminary results indicate that 153 Sm-EDTMP is a promising radiotherapeutic agent for palliative treatment of metastatic bone cancer pain where a reactor is available and at a very affordable cost. (author)

  11. Radiochemical studies, pre-clinical investigation and preliminary clinical evaluation of "1"7"0Tm-EDTMP prepared using in-house freeze-dried EDTMP kit

    International Nuclear Information System (INIS)

    Das, Tapas; Shinto, Ajit; Kamaleshwaran, Koramadai K.; Sarma, Haladhar D.; Mohammed, Sahiralam Khan; Mitra, Arpit; Lad, Sangita; Rajan, M.G.R.; Banerjee, Sharmila

    2017-01-01

    The objective of the present work is to formulate "1"7"0Tm-EDTMP using an in-house freeze-dried EDTMP kit and evaluate its potential as a bone pain palliation agent. Patient dose of "1"7"0Tm-EDTMP was prepared with high radiochemical purity using the lyophilized kit at room temperature within 15 min. Pre-clinical evaluation in normal Wistar rats revealed selective skeletal accumulation with extended retention. Preliminary clinical investigation in 8 patients with disseminated skeletal metastases exhibited selective uptake in the bone and retention therein for a long duration. - Highlights: • Formulation of patient dose of "1"7"0Tm-EDTMP using freeze-dried EDTMP kit. • Radiochemical studies and pre-clinical evaluation of the agent in animal model. • Clinical evaluation in eight cancer patients with disseminated skeletal metastases.

  12. Anticonceptivos orales combinados: Guías Latinoamericanas

    Directory of Open Access Journals (Sweden)

    David Vásquez-Awad

    2014-09-01

    Full Text Available En los últimos años se han visto importantes avances en el desarrollo de nuevos anticonceptivos orales combinados (AOC incluyendo las transiciones de altas a bajas dosis de estrógenos y la introducción de nuevas progestinas; últimamente han salido al mercado AOC con estrógeno natural, estradiol, y en cuanto a las progestinas, su uso se enfoca al logro de efectos benéfi cos no contraceptivos específi camente en piel, cabello, peso corporal y síntomas relacionados al período menstrual. Por otra parte, también se han visto avances en cuanto a la introducción de píldoras de solo progestinas, inyectables de solo progestinas y combinados, implantes subdérmicos de progestinas y de largo lazo, parches transdérmicos combinados, anillos vaginales y dispositivos intrauterinos liberadores de levonorgestrel.

  13. The physical and chemical characteristics of 175Yb-EDTMP labelled compound

    International Nuclear Information System (INIS)

    Azmairit Aziz; Marlina; Muhammad Basit Febrian

    2010-01-01

    Bone pain is a common complication for patient with bone metastases from breasts, prostate and lung cancers. The derivative of phosphonate groups, i.e. diphosphonate as well as poly phosphonate ligands e.g. EDTMP have high affinity in bone matrix. The labeled compound of 175 Yb-EDTMP can be used as an alternative radiopharmaceutical for bone pain palliation. The compound of 175 Yb-EDTMP can be produced by labeling of ethylenediamine tetramethylene phosphonic acid (EDTMP) with itterbium-175 ( 175 YbCl 3 ). Before 175 Yb-EDTMP is used for bone pain palliation in nuclear medicine, the compound have to be characterized to full fill the criteria of the good radiopharmaceutical. The physical and chemical characteristics of 175 Yb-EDTMP had been studied. It consists of: pH, solution clearity, the radiochemical purity that was determined by paper chromatography and paper electrophoresis techniques, electricity charge was determined by paper electrophoresis, stability, lipophilicity of 175 Yb-EDTMP was obtained by determination of octanol-water partition and the plasma binding protein was in-vitro investigated with precipitation method using 5% of trichloroacetic acid solution, and the binding to hydroxyapatite. From the experiment, it was obtained that the 175 Yb-EDTMP solution has the pH of 7, clear, the radiochemical purity of 98.66 ± 0.53%, and the negative electric charge. The compound of 175 Yb-EDTMP has lipophilicity (P) of 0.0135 ± 0.003%, the human plasma binding protein of 8.94 ± 0.66%, and the hydroxyapatite binding of 94.78 ± 2.16%. Stability evaluation indicated that 175 Yb-EDTMP solution was still stable for nine days at room temperature with the radiochemical purity more than 95% (98.62 ± 0.83%). This study expects that 175 Yb-EDTMP compound can fulfill the requirement as radiopharmaceutical for use in palliative treatment of painful bone metastases and supports the development of nuclear medicine in Indonesia. (author)

  14. Determination of the biodistribution and biokinetics of radiopharmaca like 166Ho-ferric-hydroxide or 153Sm-EDTMP used for therapeutic treatment by energy dispersive measurements

    International Nuclear Information System (INIS)

    Fischer, H.; Poljanc, K.; Aiginger, H.; Pruefert, U.; Granegger, S.; Ofluoglu, S.; Pirich, Ch.; Sinzinger, H.; Dudczak, R.; Steger, F.

    2003-01-01

    The activity distribution of beta-emitting radionuclides in the human body and the respective therapeutic dose distribution in the target and the unwanted leakage in the other organs was determined by measurement of corresponding gamma-lines. The measurement was done by scanning in a whole-body counter in the General Hospital Vienna. It is possible to localize activity and dose distribution by means of the detected activity profiles of the four detectors. Two typical treatments are reported: the treatment of synovitis using radiation of 166 Ho-Ferric-Hydroxide (characteristic gamma-line: 81 keV) and radionuclide therapy focused at the palliative treatment of bone metastases with 153 Sm-EDTMP, a bone seeking beta-emitting radionuclide (characteristic gamma-line: 103 keV). For the determination of the applied dose, the leakage and the quality assurance spectroscopic data of a clinical whole-body counter can be a useful tool for controlling and monitoring in health care. (authors)

  15. Combined cycle simulator with gas turbine and steam turbine with one vaporization stage; Simulador de ciclo combinado con turbina de gas y de vapor con un nivel de vaporizacion

    Energy Technology Data Exchange (ETDEWEB)

    Del Valle Cardenas, B.; Lugo Leyte, R. [Universidad Autonoma Metropolitana, Depto de Ingenieria de Procesos e Hidraulica, Mexico, D. F. (Mexico); Toledo Velazquez, Miguel; Tolentino Eslava, G. [Seccion de Estudios de Posgrado e Investigacion, Laboratorio de Ingenieria Termica e Hidraulica Aplicada, ESIME-IPN-COFFA, Mexico, D. F. (Mexico)

    1998-12-31

    This paper shows the thermal analysis of a combined cycle with gas and steam turbines with one vaporization stage. The analysis is performed through a computer program, which allows the simulation of cycles with different operational conditions, obtaining this way a series of results that permits to know the way these cycles behave in effecting temperature and pressure changes; besides of being an excellent tool in thermodynamics for the user. The simulators were performed in Borland C++ and Builder C++ Versions 4.5 and 2.0 respectively, creating in this way a friendly ambient for the user. This tool offers the opportunity to all its users the ability to simulate combined cycles in a fast and easy way in order to obtain a wider understanding of its thermodynamic behavior. [Espanol] En el presente trabajo se muestra el analisis termico de un ciclo combinado con turbinas de gas y de vapor con un nivel de vaporizacion. El analisis se realiza a traves de un programa de computo, el cual permite simular los ciclos con diferentes condiciones de operacion, obteniendo con esto una serie de resultados que permiten conocer la forma en que trabajan estos ciclos al realizar cambios en temperaturas y presiones; ademas de que es una excelente herramienta para el usuario en termodinamica. Los simuladores fueron realizados en Borland C++ y Builder C++ Versiones 4.5 y 2.0 respectivamente, creandose asi un ambiente amigable para el usuario. Esta herramienta brinda la oportunidad a todos los usuarios de poder simular ciclos combinados de una manera rapida y sencilla con el fin de obtener una comprension mas amplia de su comportamiento termodinamico.

  16. Combined cycle simulator with gas turbine and steam turbine with one vaporization stage; Simulador de ciclo combinado con turbina de gas y de vapor con un nivel de vaporizacion

    Energy Technology Data Exchange (ETDEWEB)

    Del Valle Cardenas, B; Lugo Leyte, R [Universidad Autonoma Metropolitana, Depto de Ingenieria de Procesos e Hidraulica, Mexico, D. F. (Mexico); Toledo Velazquez, Miguel; Tolentino Eslava, G [Seccion de Estudios de Posgrado e Investigacion, Laboratorio de Ingenieria Termica e Hidraulica Aplicada, ESIME-IPN-COFFA, Mexico, D. F. (Mexico)

    1999-12-31

    This paper shows the thermal analysis of a combined cycle with gas and steam turbines with one vaporization stage. The analysis is performed through a computer program, which allows the simulation of cycles with different operational conditions, obtaining this way a series of results that permits to know the way these cycles behave in effecting temperature and pressure changes; besides of being an excellent tool in thermodynamics for the user. The simulators were performed in Borland C++ and Builder C++ Versions 4.5 and 2.0 respectively, creating in this way a friendly ambient for the user. This tool offers the opportunity to all its users the ability to simulate combined cycles in a fast and easy way in order to obtain a wider understanding of its thermodynamic behavior. [Espanol] En el presente trabajo se muestra el analisis termico de un ciclo combinado con turbinas de gas y de vapor con un nivel de vaporizacion. El analisis se realiza a traves de un programa de computo, el cual permite simular los ciclos con diferentes condiciones de operacion, obteniendo con esto una serie de resultados que permiten conocer la forma en que trabajan estos ciclos al realizar cambios en temperaturas y presiones; ademas de que es una excelente herramienta para el usuario en termodinamica. Los simuladores fueron realizados en Borland C++ y Builder C++ Versiones 4.5 y 2.0 respectivamente, creandose asi un ambiente amigable para el usuario. Esta herramienta brinda la oportunidad a todos los usuarios de poder simular ciclos combinados de una manera rapida y sencilla con el fin de obtener una comprension mas amplia de su comportamiento termodinamico.

  17. Radionuclide Treatment with 153Sm-EDTMP is Effective for the Palliation of Bone Pain in the Context of Extensive Bone Marrow Metastases: A Case Report

    International Nuclear Information System (INIS)

    Kairemo, Kalevi; Rasulova, Nigora; Suslaviciute, Justina; Alanko, Tuomo

    2014-01-01

    Radionuclide therapy is widely used as an effective modality in the management of bone pain. The main indication for this treatment is symptomatic bone metastases, confirmed by bone scintigraphy. We present a case of small cell lung cancer (SCLC) stage T 4 N 2 M 1b , with a good metabolic response to systemic therapy and radiotherapy of the primary tumor and locoregional disease, which became metabolically less active and remarkably smaller in size (reduction to 1/6 of the original volume). In spite of the good overall response, the patient developed a syndrome with severe bone pain and had progression in the bone marrow metastases, confirmed by 18 F-FDG PET/CT. The patient received 153 Sm-EDTMP treatment with a good clinical response. However, in the whole body bone scan with the therapeutic dose, there was no visual evidence of bone metastasis. Retrospectively, by drawing the region of interest, it was possible to identify one metastatic site. The possible mechanisms of the efficacy of this treatment modality, in this specific setting, are also discussed

  18. Labelling of ethylenediaminetetramethylene phosphonic acid (EDTMP) with 175Yb

    International Nuclear Information System (INIS)

    Azmairit Aziz

    2009-01-01

    Ytterbium-175 ( 175 Yb) is one of radioisotopes that can be used for therapy due to its β-particle emission (T 1/2 = 4.2 d, E β(max) = 480 keV). Beside that, this radioisotope also emits γ-rays of 113 keV (1.9%), 282 keV (3.1%) and 396 keV (6.5%) which are suitable energy for imaging as long as therapeutic applications. EDTMP could be labeled with radionuclide of 175 Yb as an alternative radiopharmaceutical for bone pain palliation due to bone metastases. Labeling of ethylenediaminetetramethylenephosphonic acid with 175 Yb has been studied. Various influential parameters in labeling conditions i.e. the amount of EDTMP ligand, the pH of labeling, incubation time and the amount of 175 Yb solution were studied in order to obtain high labeling efficiency of 175 Yb-EDTMP. The labeling efficiency was obtained by radiochemical purity that was determined by paper chromatography and paper electrophoresis techniques. The optimum labeling condition was obtained at pH 7, 4 mg of EDTMP ligand, 100 µL (105 µg; 0.6 µmol) of 175 Yb solution and 30 minutes incubation time at room temperature. The complex formed was gave maximum labeling efficiency of 98.81 ± 0.15%. Owing to the results, EDTMP ligand can be labeled with 175 Yb radionuclide with labeling efficiency more than 95%. (author)

  19. Resultados de un programa de ejercicio físico combinado con electroestimulación neuromuscular en pacientes en hemodiálisis

    Directory of Open Access Journals (Sweden)

    Anna Junque Jiménez

    Full Text Available Los pacientes en hemodiálisis presentan una importante disminución de la condición física y la capacidad funcional. Ampliamente son conocidos los numerosos beneficios del ejercicio físico en los pacientes con insuficiencia renal en éstos aspectos. Hasta la fecha, existe mínima experiencia con la electroestimulación neuromuscular en los pacientes en hemodiálisis. Objetivos: 1. Analizar el efecto de un programa de entrenamiento físico intradiálisis combinado con electroestimulación neuromuscular sobre la fuerza muscular y la capacidad funcional en nuestros pacientes en hemodiálisis. 2. Analizar la seguridad, eficacia y tolerancia de la electroestimulación neuromuscular en nuestros pacientes en hemodiálisis. Métodos: Los pacientes en hemodiálisis realizaron un programa completo de entrenamiento físico mediante balones medicinales, pesas, bandas elásticas y cicloergómetros combinado con electroestimulación neuromuscular en las primeras dos horas de hemodiálisis durante 12 semanas en un estudio prospectivo unicéntrico. La electroestimulación se realizó en ambos cuádriceps usando el Compex® Theta 500i. Principales datos analizados: 1. Fuerza extensión máxima cuádriceps (FEMQ y "handgrip" brazo dominante (HG. 2. Test funcionales:"Sit to stand to sit" (STS10 y "six-minutes walking test" (6MWT. 3. Escala Visual Analógica (EVA y cuestionario propio de electroestimulación neuromuscular (QE. Resultados: 11 pacientes incluidos (55% mujeres. Edad media 67.6 años y 62.3 meses en hemodiálisis. Se observó una mejoría significativa (*p<0.05 en la FEMQ*(13.7±8.1 vs 16.2±10.9kg, HG*(23.8±15.9 vs 25.1±15.9kg, STS10*(24.6±13.4 vs 20.1±10.1 seg y 6MWT*(21%,332.6 vs 402.7 m. No observamos dolor muscular, rampas, hormigueos o calambres musculares relevantes en el cuestionario propio de electroestimulación. El grado medio de satisfacción (EVA fue 9.4 puntos. Conclusiones: 1. El programa de entrenamiento físico intradi

  20. {sup 166} Ho-EDTMP in detecting bone metastases: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Achando, S.S.; Fernandes, L.; Herrerias, R.; Muramoto, E.; Almeida, M.A.T.; Pereira, N.S. de; Mengatti, J. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)

    1995-12-31

    Holmium-166-EDTMP (ethylene-dimine-tetra methylene phosphonic acid) due to its promising biological properties, has proved to be a palliating therapeutic agent for bone cancer in human beings. In a basic medium, {sup 166} Ho-EDTMP can be readily prepared with a complexing molar ratio EDTMP/Ho 4.34. The radiochemical purity of the complex was higher than 98%. The biodistribution in rats and mice, showed a high skeletal uptake, a fast blood clearance and a low soft tissue uptake and a lesion to normal bone ratio equal to 2. (author). 3 refs., 4 tabs.

  1. Study On Preparation Of 177Lu-EDTMP For Metastatic Bone Pain Palliation Treatment

    International Nuclear Information System (INIS)

    Nguyen Thanh Binh; Dang Ho Hong Quang; Duong Van Dong; Chu Van Khoa; Nguyen Thi Hien

    2011-01-01

    Ethylene diamine tetramethylene phosphonate (EDTMP) is one of the most widely used ligands which forms stable complexes with various radionuclides and all the complexes showed high bone uptake in biodistribution studies. EDTMP has a high affinity to skeleton and osteoblastic bone metastases and many EDTMP chelates posses a considerably high stability.This stimulated application of the ligand as the in-vivo carrier of various radionuclides, intended for both therapy and diagnosis of osteoblastic lesions.The present study intends to formulate EDTMP kits, label them with 177 Lu, quality control and in-vitro stability studies. This paper presents some research results on the optimal conditions for labeling EDTMP kit with Lu-177 of low specific activity that was produced on the IVV-9 reactor at the Nuclear Research Institute. (author)

  2. Use of 153Sm-EDTMP in the treatment of painful bone metastasis (Tunis experience about 80 cases)

    International Nuclear Information System (INIS)

    Mhiri, A.; Hassad, R.; Ben Slimene, M.F.; Sellem, A.; Hammami, H.; Mahersi, M.

    2006-01-01

    Metabolic radiotherapy is a good therapeutic alternative presently proposed for the treatment of disseminated painful bone metastasis. 153 Sm-EDTMP (Quadramet is the radiopharmaceutical used in Tunisia for this indication since October 2001. We are presenting here the results of a 40-month multicentric and retrospective study carried out on 80 patients receiving this new therapy for painful bone metastasis related with various primary carcinoma. All patients received a dose of thirty seven mega-becquerel per kilogram of weight and per treatment (37 MBq/kg/treatment). Our aim was to evaluate four parameters: therapeutic efficiency, factors influencing the response to the treatment, treatment toxicity and sources of treatment failure. A positive response on pain was obtained for 82.5% of cases. This response was complete for 33.9% of them. The average duration of the antalgic protection for each injection was three months, with limits varying from 3 weeks to 12 months. The response was not influenced by the primary type, nor by the number of metastatic lesions, the previously received therapy other than chemotherapy or the general state of the patient prior to treatment. The results obtained after multiple treatments show that the therapies could be repeated with comparable results to those of the first treatment. The only toxicity was of haematological order: It was often mild and reversible with an average complete recovery after 8 weeks. Conclusion: the therapeutic efficiency of Quadramet is at least equivalent to the other therapeutical means, with nearly no side effects. Its early introduction in the management of metastatic patients would allow them to better benefit from its efficiency, simplicity and low toxicity and therefore enjoy a better quality of life. The difficulties we are facing are mainly related to coordination logistic issues during the drug imports and incidentally a lack of awareness and information of the physicians in charge. (author)

  3. Studying on process for labeling of EDTMP with 90Y using for bone pain palliation

    International Nuclear Information System (INIS)

    Pham Ngoc Dien; Duong Van Dong; Dang Ho Hong Quang; Nguyen Thanh Binh; Bui Van Cuong; Nguyen Dang Khoa; Nguyen Thi Thu; Mai Phuoc Tho; Vo Cam Hoa

    2013-01-01

    This Study describes the method for preparation of labelling compound Ethylene diamine tetramethylene phosphonic acid (EDTMP) with 90 Y. Malignant cancer is one of the most important resulting in human death. Bone metastases in nearly 25% of all cancer patients; so it is useful to develop radiopharmaceuticals for the treatment of bone cancer. Yttrium-90 is high energy (2.3 MeV) beta emitter required with a physical haft life of 2.7 days which has limited bone-seeking properties. Its physical properties make it ideal for therapeutic application, the most energetic beta emission being able to penetrate to 1 cm from the site of deposition in soft tissue with an average range of approximately 4 mm. Theoretically, therefore, it can penetrate all marrow spaces in normal trabecular bone and conceivably even to the centre of large tumours where bone destruction may be extensive. Specific deposition of 90 Y into the skeleton demands its delivery in a chemical form with affinity for bone mineral alone. Compounds with these properties are the phosphonate analogues of polyaminocarboxylic acids, and one in particular EDTMP (ethylen diamine tetra methylene phosphonate) has already been used to target 153 Sm to bone mineral with success. Because of chemical similarities between 90 Y and the rare earths, EDTMP should form stable complexes with 90 Y and carry it specifically to the bone with comparable efficiency. Skeletal uptake of β - emitting radionuclides may be used for bone pain palliation or myeloablation. The physical characteristics of the β - particles required for the two conditions are, however, different, that is, higher energies are favorable for destruction of bone marrow. (author)

  4. Performance study of a combined cycle power plant with integral gasification; Estudio del desempeno de una planta de potencia de ciclo combinado con gasificacion integral

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Rocha, Jose Clemente

    2007-04-15

    con alto valor agregado, como la gasolina, turbosina o diesel, entre otros. Con la nueva reconfiguracion de las refineria mexicanas de Cd. Madero y Cadereyta y proximamente la terminacion de la reconfiguracion de la refineria de Minatitlan, Veracruz, grandes cantidades de coque se estaran produciendo, con la posibilidad de usarlo mediante la tecnologia de gasificacion para producir un gas sintetico limpio (gasl) con caracteristicas energeticas apropiadas para utilizarse como combustible en un ciclo combinado existente en Mexico. En Mexico se han estimado las posibilidades de generacion de energia electrica a partir del uso del coque de petroleo utilizado la tecnologia de gasificacion o usando generadores de vapor de lecho fluidizado, como es el caso de las planta de potencia TEG en Taquin, San Luis Potosi. Tal es el hecho, que actualmente PEMEX refinacion, tiene terminado el proyecto para construir en Tuxpan, Veracruz una refineria procesadora de crudo Maya con un alto contenido de azufre y junto a la termoelectrica de Tuxpan, contemplandose la posibilidad de aplicar el concepto de ciclo combinado con gasificacion integrada (CCGI); con esta infraestructura sera posible consumir el coque generado por las refinerias mexicanas. La generacion electrica esperada es de 500 MW, de los cuales 100 MW seran para consumo propio de la refineria y 400 MW libres para cubrir la demanda de energia electrica de la zona noreste y centro del pais. El coque de petroleo derivado de las refinerias del pais puede ser utilizado para la generacion limpia de electricidad mediante su gasificacion e integracion a una planta de ciclo combinado existente. La ubicacion estrategia del ciclo combinado Tula, el cual se encuentra adyacente a la refineria Miguel Hidalgo presenta la oportunidad de aplicar la tecnologia de gasificacion como una alternativa viable: primeramente, para la utilizacion de coque de petroleo que actualmente se esta produciendo en las refinerias de Mexico o la utilizacion del

  5. Comparison of carrier-added [99mTc] EDTMP and carrier-free preparations of [99mTc] EDTMP and [99mTc] DPD

    International Nuclear Information System (INIS)

    Krcal, A.; Kletter, K.; Dudczak, R.; Pirich, C.; Mitterhauser, M.

    2002-01-01

    Full text: High uptake of bone-seeking radiopharmaceuticals in malignant bone lesions is a prerequisite for adequate bone scanning. Visual image analysis is impaired due to high soft-tissue activity with currently available [ 99m Tc]-EDTMP-kits. This study aimed to compare carrier-added [ 99m Tc]-EDTMP with carrier-free [ 99m Tc]-EDTMP and [ 99m Tc]-DPD preparations in clinical routine. 15 μg and 150 μg perrhenic acid respectively were added to [ 99m Tc]-pertechnetate (>6 GBq in 3 ml phys. saline). The solution was then transferred into a vial, containing 1 mg of EDTMP, 3.6 mg stannous(II)chloride and 10 mg ascorbic acid under inert conditions. Under vigorous stirring the reaction mixture was heated to 45 o C for 10 min. After cooling down to room temperature the labelling mixture was sterile filtrated (millipore 0.22 μm). Quality control was performed using radio-ITLC (Whatman SG; acetone or ethanol: R f perrhenate/pertechnetate 0.87, colloid/product 0.05; phys. saline: R f colloid 0.00, perrhenate/pertechnetate and product 0.9) allowing rapid and efficient assessment of the product. Carrier free [ 99m Tc]-EDTMP and [ 99m Tc]-DPD were prepared according to instructions of the manufacturer. Clinical studies were performed in 29 patients according to a routine bone scanning protocol by injecting 700-800 MBq of the respective tracer and whole body imaging 3 h thereafter. Radiochemical purity and radiochemical yield relied on various parameters such as concentration of carrier and reducing agent and reaction conditions (pH, reaction time, temperature). Means of the labelling yield were 22 % for the preparation using 150 μg of carrier (5 preparations), 80 % for the preparation using 15 μpg of carrier (10 preparations) and 91 % for the carrier free products (5 preparations). Radiochemical purity was >96 % in all experiments. Colloid was formed in very low amounts, and was completely removed by sterile filtration. In clinical studies quantitative analysis

  6. Effects of increasing doses of samarium-153-ethylenediaminetetramethylene phosphonate on axial and appendicular skeletal growth in juvenile rabbits

    International Nuclear Information System (INIS)

    Essman, Stephanie C.; Lewis, Michael R.; Fox, Derek B.

    2008-01-01

    Introduction: Targeted radiotherapy using samarium-153-ethylenediaminetetramethylene phosphonate ( 153 Sm-EDTMP) is currently under investigation for treatment of osteosarcoma. Osteosarcoma often occurs in children, and previous studies on a juvenile rabbit model demonstrated that clinically significant damage to developing physeal cartilage may occur as a result of systemic 153 Sm-EDTMP therapy. The aim of this study was to evaluate the late effects of 153 Sm-EDTMP on skeletal structures during growth to maturity and to determine if there is a dose response of 153 Sm-EDTMP on growth of long bones. Methods: Female 8-week-old New Zealand white rabbits were divided into three treatment groups plus controls. Each rabbit was intravenously administered a predetermined dose of 153 Sm-EDTMP. Multiple bones of each rabbit were radiographed every 2 months until physeal closure, with subsequent measurements made to assess for abbreviated bone growth. Statistical analyses were performed to determine the differences in bone length between groups, with significance set at P 153 Sm-EDTMP. Further investigation regarding the effects of bone-seeking radiopharmaceuticals on bone growth and physeal cartilage is warranted

  7. Influences of the amount of ligand on the biochemical properties of 153Sm-HEDTMP

    International Nuclear Information System (INIS)

    Yang Yuqing; Luo Shunzhong; Wang Guanquan; He Jiaheng; Pu Manfei; Bing Wenzeng

    2002-01-01

    The Effect of the amount of ligand HEDTMP on biochemical properties of 153 Sm-HEDTMP is studied. The biochemical properties include partition coefficient of 153 Sm-HEDTMP in n-octanol-water which is measured by shake-flask method, combination characteristic with BSA (bovine serum albumin) which is measured through precipitation by TCA (trichloroacetic acid) and adsorption characteristic on HA (hydroxyapatite) which is measured with the same method used in 153 Sm-EDTMP. It is found that, with the increasing in the amount of ligand, partition coefficient of 153 Sm-HEDTMP. It is found that, with the increase in the amount of ligand, partition coefficient of 153 Sm-HEDTMP in n-octanol-water decreases, so does combination percentage with BSA, but the adsorption percentage on HA shows a little and unremarkable decrease. Considering the relationships between these three biochemical properties and in vivo metabolism of 153 Sm-HEDTMP this study supports the view that an appropriate high amount of ligand should be applied in practical use

  8. Synthesis of Ethylene diamine tetra methylene phosphonic acid EDTMP

    International Nuclear Information System (INIS)

    Assaad, Th.

    2009-06-01

    Ethylenediamine tetramethylene phosphonic acid (EDTMP) is one of the most widely used ligands which forms stable complexes with various radionuclides all of which have shown high bone affinity and other favorable pharmacological characteristics in biodistribution studies. The EDTMP is very important precursor in the preparation of radiopharmaceutical kits which is used in the applications for bone diagnosis and therapy was synthesized in one step with Mannich type reaction. The obtained product was fully characterized by its multi-nuclear NMR and IR spectroscopy. The purity of the product was confirmed by HPLC. (author)

  9. Efectos del ejercicio aeróbico interválico, combinado con entrenamiento de fuerza y de la restricción calórica, sobre la composición corporal de ratas obesas

    Directory of Open Access Journals (Sweden)

    I. Coll-Risco

    2017-03-01

    Conclusiones: Tanto el programa de ejercicio aeróbico interválico, combinado con entrenamiento de fuerza desarrollado, como la restricción calórica, fueron eficaces, mejorando la composición corporal de ratas obesas, pero el ejercicio lo hizo en mayor magnitud.

  10. New therapeutic agent for radiation synovectomy - preparation of 166Ho-EDTMP-HA particle

    International Nuclear Information System (INIS)

    Bai, H.; Jin, X.; Du, J.; Wang, F.; Chen, D.; Fan, H.; Cheng, Z.; Zhang, J.

    1997-01-01

    In order to prepare new therapeutical agent for radiation synovectomy, Hydroxyapatite (HA) was labelled with 166 Ho by EDTMP that had high affinity to HA particles. Radiolabelling of HA particles was divided into two steps, 166 Ho-EDTMP was prepared first; then mixed with HA particles completely and vibrated for 15 minutes on the micromixer at room temperature, washed 3 times with deionized water. Radiolabelling particle was separated from free 166 Ho via centrifugation to determine its radiolabelling efficiency. 166 Ho-EDTMP-HA and 166 Ho-EDTMP were injected into knee joint of normal rabbits respectively, every group was killed at different time postinjection, took out major organ and collected urine and blood, then weighted and determined their radio counts. HA particles, as a natural component of bone was known to have good compatibility with soft tissue and biodegrade into calcium and phosphate in vivo. It was readily prepared from common chemical and formed into particles of desired size range in a controlled process, it had high stability in vitro and vivo. Radiolabelling of HA particle with 166 Ho by EDTMP was simple to perform and provides an excellent labelling yield that was more than 95% under the optimal labelling condition. The optimal labelling condition at room temperature was pH 6.0-8.0 and vibration time 15 minutes. The absorbed capacity of HA particle was 5 mg Ho/g HA particle and size of radiolabelling particle was at range of 2-5,μm that is suitable for therapy of radiation synovectomy. 166 Ho-EDTMP-HA particle demonstrated high in vitro stability in either normal saline or 1% BSA solution, but instability under extremely acidic condition (pH 1-2). The control studies performed with 166 Ho-EDTMP not bound to HA particle provided information on the distribution of radioactivity that would occur upon leakage of the radiochemical compound from joint. Its short half-life, its extremely low leakage from the joint and its even distribution throughout

  11. External exposure in radionuclide therapy with 153 Sm

    Energy Technology Data Exchange (ETDEWEB)

    Rezio, M.T.; Vieira, M.R. [Instituto Portugues Oncologia de Francisco Gentil, CROL, Lisboa (Portugal)

    2006-07-01

    Full text of publication follows: Aim: The radiopharmaceutical 153 Sm is an beta emitter used in metastatic bone pain palliation. The prescribed activity is 37 MBq/kg body weight.. The aim of this study is to measure the dose rate of the patients during 4 to 6 hours after 153 Sm - E.D.T.M.P. administration in order to prevent external exposure of nursing staff, family members and general public. Material and Methods: Twelve patients were treated with 153 Sm in our department. External exposure rates( {mu}Sv/h) at different times and at one meter were measured, with a Geiger-Muller detector. Results: The mean dose rate at one meter was 12 {mu}Sv/h, one hour after injection and 3{mu} Sv/h, 6 hours after injection. Conclusion: The policy in our department is to keep the patient in the hospital 4-6 h, due to the risk of contamination. Based on our results, the external exposure of the nursing staff, family members and the general public is very low, in agreement with other studies. (authors)

  12. External exposure in radionuclide therapy with 153 Sm

    International Nuclear Information System (INIS)

    Rezio, M.T.; Vieira, M.R.

    2006-01-01

    Full text of publication follows: Aim: The radiopharmaceutical 153 Sm is an beta emitter used in metastatic bone pain palliation. The prescribed activity is 37 MBq/kg body weight.. The aim of this study is to measure the dose rate of the patients during 4 to 6 hours after 153 Sm - E.D.T.M.P. administration in order to prevent external exposure of nursing staff, family members and general public. Material and Methods: Twelve patients were treated with 153 Sm in our department. External exposure rates( μSv/h) at different times and at one meter were measured, with a Geiger-Muller detector. Results: The mean dose rate at one meter was 12 μSv/h, one hour after injection and 3μ Sv/h, 6 hours after injection. Conclusion: The policy in our department is to keep the patient in the hospital 4-6 h, due to the risk of contamination. Based on our results, the external exposure of the nursing staff, family members and the general public is very low, in agreement with other studies. (authors)

  13. Technical and environmental aspects of combined cycle power stations with integrated gasification (CCGI); Aspectos tecnicos y medioambientales de las centrales de ciclo combinado con gasificacion integrada (CCGI)

    Energy Technology Data Exchange (ETDEWEB)

    Beltran Mora, Hector Alejandro; Urias Romero, Francisco [Facultad de Ingenieria, Universidad Nacional Autonoma de Mexico, Mexico, D.F. (Mexico)

    2004-06-15

    A description is presented of the operation of the Combined Cycle Power Stations with Integrated Gasification (CCGI) where the use of solid fuels (coal, vacuum residues, petroleum coke, and biomass) or liquids is possible in a thermal power station with the efficiency and many of the own environmental benefits of the combined cycles. The gasification process is analyzed, that is a thermo-chemical process by means of which a fuel that is in solid state or liquid becomes to the gaseous state by means of a partial oxidation and the obtained gas of this process is called synthesis gas (syngas, by its abbreviations in English) that is used in Combined Cycle Power Stations as a substitute for the natural gas. Also the other components of this type of power stations are shown, such as the air separating unit, and some of the modifications that are due to make to adapt a gas turbine so that it uses syngas, and the considerations of their integration with the air separating unit to optimize the operation of the plant are detailed. A comparison of efficiency values of power stations CCGI with the conventional carbon-electric and the power stations of combined cycle that use natural gas is also shown. Finally the emissions of pollutants of SO{sub 2}, NO{sub x} and CO{sub 2} are analyzed. The possibility of using fuels like petroleum coke and vacuum tower residues that are produced in the Cadereyta refinery is studied for the possible construction of a CCGI power station in Mexico. [Spanish] Se presenta la descripcion del funcionamiento de las centrales ciclo combinado con gasificacion integrada (CCGI) donde es posible el uso de combustibles solidos (carbon, residuos de vacio, coque de petroleo, biomasa) o liquidos en una central termica con la eficiencia y muchos de los beneficios ambientales propios de los ciclos combinados. Se analiza el proceso de gasificacion, que es un proceso termoquimico mediante el cual se convierte un combustible que se encuentra en estado solido o

  14. New therapeutic agent for radiation synovectomy - preparation of {sup 166}Ho-EDTMP-HA particle

    Energy Technology Data Exchange (ETDEWEB)

    Bai, H.; Jin, X.; Du, J.; Wang, F.; Chen, D.; Fan, H.; Cheng, Z.; Zhang, J. [China Institute of Atomic Energy, Beijing (Switzerland). Isotope Department

    1997-10-01

    In order to prepare new therapeutical agent for radiation synovectomy, Hydroxyapatite (HA) was labelled with {sup 166}Ho by EDTMP that had high affinity to HA particles. Radiolabelling of HA particles was divided into two steps, {sup 166}Ho-EDTMP was prepared first; then mixed with HA particles completely and vibrated for 15 minutes on the micromixer at room temperature, washed 3 times with deionized water. Radiolabelling particle was separated from free {sup 166}Ho via centrifugation to determine its radiolabelling efficiency. {sup 166}Ho-EDTMP-HA and {sup 166}Ho-EDTMP were injected into knee joint of normal rabbits respectively, every group was killed at different time postinjection, took out major organ and collected urine and blood, then weighted and determined their radio counts. HA particles, as a natural component of bone was known to have good compatibility with soft tissue and biodegrade into calcium and phosphate in vivo. It was readily prepared from common chemical and formed into particles of desired size range in a controlled process, it had high stability in vitro and vivo. Radiolabelling of HA particle with {sup 166}Ho by EDTMP was simple to perform and provides an excellent labelling yield that was more than 95% under the optimal labelling condition. The optimal labelling condition at room temperature was pH 6.0-8.0 and vibration time 15 minutes. The absorbed capacity of HA particle was 5 mg Ho/g HA particle and size of radiolabelling particle was at range of 2-5,{mu}m that is suitable for therapy of radiation synovectomy. {sup 166}Ho-EDTMP-HA particle demonstrated high in vitro stability in either normal saline or 1% BSA solution, but instability under extremely acidic condition (pH 1-2). The control studies performed with {sup 166}Ho-EDTMP not bound to HA particle provided information on the distribution of radioactivity that would occur upon leakage of the radiochemical compound from joint. Its short half-life, its extremely low leakage from the

  15. Biodistribution of samarium-153-EDTMP in rats treated with docetaxel Biodistribuição de EDTMP-153-samário em ratos tratados com docetaxel

    Directory of Open Access Journals (Sweden)

    Arthur Villarim Neto

    2009-02-01

    Full Text Available PURPOSE: Many patients with metastatic bone disease have to use radiopharmaceuticals associated with chemotherapy to relieve bone pain. The aim of this study was to assess the influence of docetaxel on the biodistribution of samarium-153-EDTMP in bones and other organs of rats. METHODS: Wistar male rats were randomly allocated into 2 groups of 6 rats each. The DS (docetaxel/samarium group received docetaxel (15 mg/kg intraperitoneally in two cycles 11 days apart. The S (samarium/control group rats were not treated with docetaxel. Nine days after chemotherapy, all the rats were injected with 0.1ml of samarium-153-EDTMP via orbital plexus (25µCi. After 2 hours, the animals were killed and samples of the brain, thyroid, lung, heart, stomach, colon, liver, kidney and both femurs were removed. The percentage radioactivity of each sample (% ATI/g was determined in an automatic gamma-counter (Wizard-1470, Perkin-Elmer, Finland. RESULTS: On the 9th day after the administration of the 2nd chemotherapy cycle, the rats had a significant weight loss (314.50±22.09g compared (pOBJETIVO: Muitos pacientes com metástases ósseas são tratados com radiofármacos associados com quimioterapia para alívio da dor óssea. O objetivo do trabalho foi estudar a influência do docetaxel na biodistribuição do EDTMP-153-samário nos ossos e outros órgãos de ratos. MÉTODOS: Ratos Wistar foram aleatoriamente alocados em 2 grupos de 6 animais cada. O grupo DS (docetaxel/samário recebeu docetaxel (15 mg/kg intraperitoneal em dois ciclos com 11 dias de intervalo. Os ratos do grupo S (samário/controle não foram tratados com docetaxel. Nove dias após a quimioterapia, todos os animais receberam 0,1ml de EDTMP-153-samário via plexo orbital (25µCi. Após 2 horas, os animais foram mortos e feitas biópsias de cérebro, tireóide, pulmão, coração, estômago, cólon, fígado, rim e fêmures. O percentual de radioatividade por grama (%ATI/g de tecido de cada bi

  16. Retrospective evaluation of bone pain palliation after samarium-153-EDTMP therapy Avaliação retrospectiva do tratamento da dor óssea metastática com Samário-153-EDTMP

    Directory of Open Access Journals (Sweden)

    Marcelo Tatit Sapienza

    2004-01-01

    Full Text Available PURPOSE: The aim of this study was to evaluate the degree of metastatic bone pain palliation and medullar toxicity associated with samarium-153-EDTMP treatment. METHODS: Seventy-three patients with metastatic bone pain having previously undergone therapy with samarium-153-EDTMP (1 mCi/kg were retrospectively evaluated. Routine follow-up included pain evaluation and blood counts for 2 months after treatment. Pain was evaluated using a subjective scale (from 0 to 10 before and for 8 weeks after the treatment. Blood counts were obtained before treatment and once a week for 2 months during follow-up. Dosimetry, based upon the urinary excretion of the isotope, was estimated in 41 individuals, and the resulting radiation absorbed doses were correlated with hematological data. RESULTS: Reduction in pain scores of 75% to 100% was obtained in 36 patients (49%, with a decrease of 50% to 75%, 25% to 50%, and 0% to 25% in, respectively, 20 (27%, 10 (14%, and 7 (10% patients. There was no significant relationship between the pain response and location of the primary tumor (breast or prostate cancer. Mild to moderate myelosuppression was noted in 75.3% of patients, usually with hematological recovery at 8 weeks. The mean bone marrow dose was 347 ± 65 cGy, and only a weak correlation was found between absorbed dose and myelosuppression (Pearson coefficient = .4. CONCLUSIONS: Samarium-153-EDTMP is a valuable method for metastatic bone pain palliation. A mild to moderate and transitory myelosuppression is the main toxicity observed after samarium therapy, showing a weak correlation with dosimetric measures.OBJETIVO: O presente trabalho teve por objetivo avaliar o efeito paliativo da dor e a toxicidade medular associados ao tratamento com Samário-153-EDTMP em pacientes com metástases ósseas. MÉTODOS: O estudo foi realizado de forma retrospectiva, a partir do levantamento de prontuário de 178 pacientes submetidos a tratamento com 1mCi/kg de 153Sm-EDTMP

  17. Multispecies animal investigation on biodistribution, pharmacokinetics and toxicity of 177Lu-EDTMP, a potential bone pain palliation agent

    International Nuclear Information System (INIS)

    Mathe, Domokos; Balogh, Lajos; Polyak, Andras; Kiraly, Reka; Marian, Terez; Pawlak, Dariusz; Zaknun, John J.; Pillai, Maroor R.A.; Janoki, Gyozo A.

    2010-01-01

    Introduction: Radionuclide therapy (RNT) is an effective method for bone pain palliation in patients suffering from bone metastasis. Due to the long half-life, easy production and relatively low β- energy, 177 Lu [T 1/2 =6.73 days, E βmax =497 keV, E γ =113 keV (6.4%), 208 keV (11%)]-based radiopharmaceuticals offer logistical advantage for wider use. This paper reports the results of a multispecies biodistribution and toxicity studies of 177 Lu-EDTMP to collect preclinical data for starting human clinical trials. Methods: 177 Lu-EDTMP with radiochemical purity greater than 99% was formulated by using a lyophilized kit of EDTMP (35 mg of EDTMP, 5.72 g of CaO and 14.1 mg of NaOH). Biodistribution studies were conducted in mice and rabbits. Small animal imaging was performed using NanoSPECT/CT (Mediso, Ltd., Hungary) and digital autoradiography. Gamma camera imaging was done in rabbits and dogs. Four levels of activity (9.25 through 37 MBq/kg body weight) of 177 Lu-EDTMP were injected in four groups of three dogs each to study the toxicological effects. Results: 177 Lu-EDTMP accumulated almost exclusively in the skeletal system (peak ca. 41% of the injected activity in bone with terminal elimination half-life of 2130 and 1870 h in mice and rabbits, respectively) with a peak uptake during 1-3 h. Excretion of the radiopharmaceutical was through the urinary system. Imaging studies showed that all species (mouse, rat, rabbit and dog) take up the compound in regions of remodeling bone, while kidney retention is not visible after 1 day postinjection (pi). In dogs, the highest applied activity (37 MBq/kg body weight) led to a moderate decrease in platelet concentration (mean, 160 g/L) at 1 week pi with no toxicity. Conclusion: The protracted effective half-life of 177 Lu-EDTMP in bone supports that modifying the EDTMP molecule by introducing 177 Lu does not alter its biological behaviour as a specific bone-seeking tracer. Species-specific pharmacokinetic behavior

  18. Concepto de padres combinados

    Directory of Open Access Journals (Sweden)

    José de Jesús Gonzáles Núñez

    Full Text Available En el presente artículo se presenta el concepto de padres combinados que se refiere a la percepción indiferenciada del bebé acerca del coito parental, en donde el niño percibe que el padre está contenido en la madre, por lo que no reconoce las funciones y atributos del padre, ya que pertenecen a la madre. Se distingue la ubicación teórica del concepto que corresponde a la fase esquizoparanoide de Melanie Klein, los mecanismos de defensa utilizados, así como las manifestaciones clínicas. Se expone un caso que muestra que la persona que posee la fantasía de padres combinados manifiesta una percepción parcial de los objetos, así como una gran falla en la diferenciación de los mismos, que crea la fantasía en la persona de que él mismo los reúne y los combina, situación que le resulta angustiosa, experimentando envidia y anhelo hacia los padres combinados, así como temor a la retaliación por haber dirigido hacia ellos sus impulsos sádicos.

  19. Effects of increasing doses of samarium-153-ethylenediaminetetramethylene phosphonate on axial and appendicular skeletal growth in juvenile rabbits

    Energy Technology Data Exchange (ETDEWEB)

    Essman, Stephanie C. [Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, MO 65211 (United States)], E-mail: essmans@missouri.edu; Lewis, Michael R. [Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, MO 65211 (United States); Department of Radiology, University of Missouri-Columbia, Columbia, MO 65211 (United States); Nuclear Science and Engineering Institute, University of Missouri-Columbia, Columbia, MO 65211 (United States); Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201 (United States); Fox, Derek B. [Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, MO 65211 (United States)

    2008-02-15

    Introduction: Targeted radiotherapy using samarium-153-ethylenediaminetetramethylene phosphonate ({sup 153}Sm-EDTMP) is currently under investigation for treatment of osteosarcoma. Osteosarcoma often occurs in children, and previous studies on a juvenile rabbit model demonstrated that clinically significant damage to developing physeal cartilage may occur as a result of systemic {sup 153}Sm-EDTMP therapy. The aim of this study was to evaluate the late effects of {sup 153}Sm-EDTMP on skeletal structures during growth to maturity and to determine if there is a dose response of {sup 153}Sm-EDTMP on growth of long bones. Methods: Female 8-week-old New Zealand white rabbits were divided into three treatment groups plus controls. Each rabbit was intravenously administered a predetermined dose of {sup 153}Sm-EDTMP. Multiple bones of each rabbit were radiographed every 2 months until physeal closure, with subsequent measurements made to assess for abbreviated bone growth. Statistical analyses were performed to determine the differences in bone length between groups, with significance set at P<.05. Results: Significant differences in lengths of multiple bones were detected between the high-dose group and other treatment groups and controls at each time interval. A significant difference in lengths of the tibias was also noted in the medium-treatment group, compared to controls. Mean reduction of bone length was first detected at 4 months and did not increase significantly over time. Conclusions: These data suggest that clinically significant bone shortening may occur as a result of high-dosage administration of {sup 153}Sm-EDTMP. Further investigation regarding the effects of bone-seeking radiopharmaceuticals on bone growth and physeal cartilage is warranted.

  20. Ethylenediaminetetramethylene phosphate labelled with Indium-113 m (sup(113m)In-EDTMP) in bone scintigraphy

    International Nuclear Information System (INIS)

    Guzman Acevedo, C.

    1981-08-01

    Studies aimed at evaluating the utility of sup(113m)In-EDTMP as a bone imaging agent in regions of the world where supplies of sup(99m)Tc are difficult to ensure are reported. Preliminary studies were concerned with characterization of unlabelled EDTMP, its toxicity in rats, its labelling with sup(113m)In and the radiochemical purity of the labelled product. Dosimetric studies were carried out with the labelled product on 15 normal human volunteers after intravenous administration of the labelled material. Preliminary imaging studies were carried out on 5 normal human volunteers. Finally, clinical studies were carried out on 199 patients with various diseases involving bone. It is concluded that sup(113m)In-EDTMP is a appropriate agent to use for bone imaging where sup(99m)Tc is unavailable

  1. Clinical and clinicopathologic response of canine bone tumor patients to treatment with samarium-153-EDTMP

    International Nuclear Information System (INIS)

    Lattimer, J.C.; Corwin, L.A. Jr.; Stapleton, J.; Volkert, W.A.; Ehrhardt, G.J.; Ketring, A.R.; Anderson, S.K.; Simon, J.; Goeckeler, W.F.

    1990-01-01

    Forty dogs with spontaneous skeletal neoplasia were treated with 153Sm-EDTMP (ethylenediaminetetramethylene phosphonic acid). Both primary and metastatic lesions were treated. Two treatment regimes, a single (37 MBq (1.0 mCi)/kg dose or two 37 MBq (1.0 mCi)/kg doses separated by 1 wk) were tested. Response to treatment was varied. Large lesions with minimal tumor bone formation responded poorly, while primary lesions with substantial ossification usually exhibited a transient response. Small lesions with minimal lysis, metastatic lesions, and axial skeleton lesions generally responded well. The major adverse side effects of treatment were platelet and white blood cell count depression below baseline values for up to 4 wk (p less than 0.05). Minor depression of packed cell volume and transient elevation of serum alkaline phosphatase were also noted (p less than 0.05). No significant differences (p greater than 0.05) between the two treatment groups, either in treatment effect or undesirable side effects, were detected

  2. Multispecies animal investigation on biodistribution, pharmacokinetics and toxicity of {sup 177}Lu-EDTMP, a potential bone pain palliation agent

    Energy Technology Data Exchange (ETDEWEB)

    Mathe, Domokos [Department of Applied Radioisotopes and Animal Experimentation, National ' Frederic Joliot-Curie' Institute of Radiobiology and Radiohygiene, H-1221 Budapest (Hungary)], E-mail: mdomokos@hp.osski.hu; Balogh, Lajos; Polyak, Andras; Kiraly, Reka [Department of Applied Radioisotopes and Animal Experimentation, National ' Frederic Joliot-Curie' Institute of Radiobiology and Radiohygiene, H-1221 Budapest (Hungary); Marian, Terez [Institute of Nuclear Medicine, Debrecen University, Debrecen (Hungary); Pawlak, Dariusz [Institute of Atomic Energy, Radioisotope Centre POLATOM, Swierk-Otwock (Poland); Zaknun, John J.; Pillai, Maroor R.A. [International Atomic Energy Agency (IAEA), Vienna (Austria); Janoki, Gyozo A. [Department of Applied Radioisotopes and Animal Experimentation, National ' Frederic Joliot-Curie' Institute of Radiobiology and Radiohygiene, H-1221 Budapest (Hungary)

    2010-02-15

    Introduction: Radionuclide therapy (RNT) is an effective method for bone pain palliation in patients suffering from bone metastasis. Due to the long half-life, easy production and relatively low {beta}- energy, {sup 177}Lu [T{sub 1/2}=6.73 days, E{sub {beta}}{sub max}=497 keV, E{sub {gamma}}=113 keV (6.4%), 208 keV (11%)]-based radiopharmaceuticals offer logistical advantage for wider use. This paper reports the results of a multispecies biodistribution and toxicity studies of {sup 177}Lu-EDTMP to collect preclinical data for starting human clinical trials. Methods: {sup 177}Lu-EDTMP with radiochemical purity greater than 99% was formulated by using a lyophilized kit of EDTMP (35 mg of EDTMP, 5.72 g of CaO and 14.1 mg of NaOH). Biodistribution studies were conducted in mice and rabbits. Small animal imaging was performed using NanoSPECT/CT (Mediso, Ltd., Hungary) and digital autoradiography. Gamma camera imaging was done in rabbits and dogs. Four levels of activity (9.25 through 37 MBq/kg body weight) of {sup 177}Lu-EDTMP were injected in four groups of three dogs each to study the toxicological effects. Results: {sup 177}Lu-EDTMP accumulated almost exclusively in the skeletal system (peak ca. 41% of the injected activity in bone with terminal elimination half-life of 2130 and 1870 h in mice and rabbits, respectively) with a peak uptake during 1-3 h. Excretion of the radiopharmaceutical was through the urinary system. Imaging studies showed that all species (mouse, rat, rabbit and dog) take up the compound in regions of remodeling bone, while kidney retention is not visible after 1 day postinjection (pi). In dogs, the highest applied activity (37 MBq/kg body weight) led to a moderate decrease in platelet concentration (mean, 160 g/L) at 1 week pi with no toxicity. Conclusion: The protracted effective half-life of {sup 177}Lu-EDTMP in bone supports that modifying the EDTMP molecule by introducing {sup 177}Lu does not alter its biological behaviour as a specific bone

  3. Combined cycles, impacts of technological requirements; Ciclos combinados, impactos de requerimientos tecnologicos

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Santalo, Jose Miguel [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico)

    1999-07-01

    The fundamental growth of the Mexican electrical sector for the next ten years is planned on base of the installation of 20 thousand Mw plants of combined cycle. This article presents an analysis of the impact of these power stations finding out that the power stations of combined cycle are at the moment cheaper - from 600 to 700 dollars by installed kW- than the alternative coal options or fuel oil, that are in the range of 900 to 1200 dollars per kW, in addition to which the time required for their construction is shorter. [Spanish] El crecimiento fundamental del sector electrico mexicano para los proximos diez anos esta planeado con base en la instalacion de 20 mil Mw de plantas de ciclo combinado. Este articulo presenta un analisis del impacto de dichas centrales encontrando que las centrales de ciclo combinado actualmente resultan mas baratas - de 600 a 700 dolares por kW instalado - que las opciones alternativas de carbon o combustoleo que estan en el rango de 900 a 1200 dolares por kW, ademas de que los tiempos requeridos para su construccion son menores.

  4. Láser helio-neón combinado con clorhexidina al 0,2 %.: Efectos clínicos y microbiológicos en el tratamiento de la gingivitis crónica

    Directory of Open Access Journals (Sweden)

    Tatiana Peña Ruiz

    Full Text Available La gingivitis crónica constituye una de las formas más frecuentes de enfermedad periodontal, caracterizada por la inflamación crónica de la encías, tumefacción, enrojecimiento y sangramiento. Su principal factor de riesgo lo constituye la microbiota del surco gingival, que resulta necesario, pero no suficiente para desencadenarla. Se realizó un ensayo clínico-terapéutico fase II, controlado, aleatorizado y a simple ciegas, para evaluar los efectos clínicos y microbiológicos del tratamiento combinado de la radiación láser helio-neón (He-Ne con la clorhexidina al 0,2 %. Todos los pacientes recibieron tratamiento inicial; al mes de finalizado este, se distribuyeron aleatoriamente en 2 grupos: un grupo estudio que recibió la combinación láser-neón y clorhexidina al 0,2 % y otro grupo control que solo recibió clorhexidina al 0,2 %. Se realizó una evaluación a los 15, 30 y 45 días, con criterios de eficacia clínicos y microbiológicos. Los resultados clínicos fueron satisfactorios en el grupo estudio con predominio de los morfotipos I, caracterizados por cocos gramnegativos y positivos, compatibles con un periodonto sano. Los eventos adversos detectados con esta terapéutica fueron mínimos, todos relacionados con la somnolencia.

  5. 153Sm-lexidronam for augmentation of chemotherapy-based myeloablative regimes in patients with multiple myeloma and other haematological conditions undergoing bone marrow transplantation: a phase I dose-escalation trial

    International Nuclear Information System (INIS)

    Macfarlane, D.J.; Durrant, S.; Gillett, E.A.; Bartlett, M.; Allison, R.; Hicks, R.; Prince, M.

    1999-01-01

    Full text: Total body irradiation (TBI) is a useful conditioning regimen for bone marrow transplantation (BMT), but has unacceptable toxicity in some patients. High doses of bone-seeking radiopharmaceuticals may offer a useful alternative to TBI in BMT patients with marrow-based tumours. Nine patients (5 multiple myeloma [MM], 2 leukaemia, 1 lymphoma, I myelodysplasia) were enrolled in a dose escalation protocol based upon retained skeletal activity. Infused doses have ranged between 18 and 32 GBq of 153 Sm-EDTMP in six patients treated. No adverse effects related to the infusion have been seen. Peripheral blood counts fell from day 7 post-treatment, persisting to the start of cytotoxic conditioning regimen at days 11-14 post-treatment. Five patients have engrafted, with one allogeneic transplant patient dying from acute rejection. Pre-treatment dosimetry was performed by gamma camera and whole-body probe counts. Post-therapy activities were estimated by serial dose meter readings and gamma camera images. The pre-treatment skeletal retention by gamma camera was 1.7-2.4 times the values based on probe data. Retained post-treatment skeletal activity predicted by dosimetry was significantly greater than that actually measured, confirmed in one case by urinary collection. This latter fact is most likely due to the nature of the interaction of 153 Sm-EDTMP with bone at high doses

  6. Investigation of complexes with bone affinity using the In vivo generator system {sup 166} Dy/{sup 166} Ho; Investigacion de complejos con afinidad osea utilizando el Sistema de Generador in vivo {sup 166} Dy/{sup 166} Ho

    Energy Technology Data Exchange (ETDEWEB)

    Pedraza L, M

    2006-07-01

    The importance of this original research lies in the fact that it has proven that the [{sup 166}Dy]Dy/{sup 166}Ho-EDTMP in vivo generator system is a stable complex that can be used as a therapeutic radiopharmaceutical. Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. Bone-seeking radiopharmaceuticals such as {sup 166}Ho-DOTMP or {sup 153}Sm-DTMP, have been proposed for delivering ablative radiation doses to marrow in multiple myeloma and other hematological malignancies or have shown excellent results in palliative bone metastasis pain therapy, respectively. As lanthanides have similar chemical characteristics the phosphonate with bone affinity (EDTMP) labeled with Dy/Ho can be used for marrow ablation while causing minimal irradiation to normal organs. This in vivo generator system has not been previously reported. The aim of this research was to label EDTMP (ethylene diamine tetramethylene phosphonate) with {sup 166}Dy/{sup 166}Ho; to evaluate the in vitro and in vivo stability of both {sup 166}Dy-EDTMP and {sup 166}Ho-EDTMP complexes when the daughter {sup 166}Ho is formed as a dysprosium decay product; to determine the bone marrow cytotoxic and genotoxic effect in mice and to evaluate, by histopathology, the myeloablative potential of the [{sup 166}Dy]Dy/{sup 166}Ho-EDTMP in vivo generator system. {sup 166}Dy was obtained by neutron irradiation of enriched {sup 164}Dy{sub 2}O{sub 3} in a TRIGA Mark III reactor. Labeling was carried out in an aqueous phosphate medium at pH 8.0 by addition of {sup 166}DyCl{sub 3} to EDTMP at a molar ratio 1:1.75, with >99 % radiochemical purity, as determined by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). In vitro studies demonstrated that {sup 166}Dy/{sup 166}Ho-EDTMP is unstable after dilution in saline but stable in human serum with no translocation of the daughter nucleus

  7. Resistencia a antimicrobianos y evaluación del tratamiento combinado en la septicemia neonatal

    Directory of Open Access Journals (Sweden)

    María Espino Hernández

    2003-04-01

    Full Text Available OBJETIVOS: Estudiar la resistencia a los antibióticos de las cepas bacterianas aisladas de pacientes con septicemia neonatal en un hospital ginecobstétrico de La Habana, Cuba, en el período comprendido entre enero de 1994 y diciembre de 1998, y evaluar el valor predictivo del método del "tablero de damas" (checkerboard para seleccionar el tratamiento con combinaciones de antibióticos en pacientes graves. MÉTODOS: Se estudió a 229 neonatos, a quienes se les extrajo sangre para hemocultivo y estudios de sensibilidad a antimicrobianos. El estudio de la susceptibilidad de las cepas se realizó por el método de microdilución en caldo y se utilizó el tablero de damas en bandejas de caldo para evaluar la eficacia del tratamiento antimicrobiano combinado. RESULTADOS: Cincuenta por ciento de las cepas aisladas de Staphylococcus spp. coagulasa-negativas y 37% de las cepas de S. aureus, principales agentes causales de sepsis neonatal, fueron resistentes a la meticilina. De ellas, 94,5% resultaron resistentes a varios antibióticos. Cuatro cepas de Staphylococcus spp. coagulasa-negativas y una de Enterococcus faecium fueron resistentes a la vancomicina (concentración mínima inhibidora = 128 myg/mL. Se observó una alta probabilidad de eficacia clínica (P < 0,01 con combinaciones de antibióticos que mostraron un efecto sinérgico in vitro, mientras que las reacciones antagónicas se correspondieron con la probabilidad altamente significativa de fracaso terapéutico clínico. DISCUSIÓN: La principal causa de septicemia neonatal en la Unidad de Cuidados Intensivos del Hospital "América Arias" en La Habana, Cuba, está constituida por las cepas de estafilococo resistentes a la meticilina y a otros antibióticos. En pacientes graves (atendiendo a lo establecido en el programa de política de este centro, la primera línea de tratamiento la constituye la combinación de un antibiótico aminoglucósido con un betalactámico. Este estudio demostr

  8. Cytotoxic and genotoxic effect of the [166Dy]Dy/166Ho-EDTMP in vivo generator system in mice

    International Nuclear Information System (INIS)

    Pedraza-Lopez, Martha; Ferro-Flores, Guillermina; Arteaga de Murphy, Consuelo; Morales-Ramirez, Pedro; Piedras-Ross, Josefa; Murphy-Stack, Eduardo; Hernandez-Oviedo, Omar

    2004-01-01

    Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. [ 166 Dy]Dy/ 166 Ho-ethylenediaminetetramethylene phosphonate (EDTMP) forms a stable in vivo generator system with selective skeletal uptake in mice; therefore, it could work as a potential and improved agent for marrow ablation. Induced bone marrow cytotoxicity and genotoxicity are determined by the reduction of reticulocytes (RET) and elevation of micronucleated reticulocyte (MN-RET) in peripheral blood and ablation by bone marrow histological studies. The aim of this study was to determine the bone marrow cytotoxic and genotoxic effect of the [ 166 Dy]Dy/ 166 Ho-EDTMP in vivo generator system in mice and to evaluate by histopathology its myeloablative potential. Enriched 166 Dy 2 O 3 was irradiated and [ 166 Dy]DyCl 3 was added to EDTMP in phosphate buffer (pH 8.0) in a molar ratio of 1:1.75. QC was determined by TLC. Dy-EDTMP complex was prepared the same way with nonirradiated dysprosium oxide. A group of BALB/c mice were intraperitoneally injected with the radiopharmaceutical and two groups of control animals were injected with the cold complex and with 0.9% sodium chloride, respectively. A blood sample was taken at the beginning of the experiments and every 48 h for 12 days postinjection. The animals were sacrificed, organs of interest taken out and the radioactivity determined. The femur was used for histological studies. Flow cytometry analysis was used to quantify the frequency of RET and MN-RET in the blood samples. The MCNP4B Monte Carlo computer code was used for dosimetry calculations. Radiochemical purity was 99% and the mean specific activity was 1.3 MBq/mg. The RET and MN-RET frequency were statistically different in the treatment at the end of the 12-day period demonstrating cytotoxicity and genotoxicity induced by the in vivo generator system. The histology studies show that there was

  9. Investigation of complexes with bone affinity using the In vivo generator system {sup 166} Dy/{sup 166} Ho; Investigacion de complejos con afinidad osea utilizando el Sistema de Generador in vivo {sup 166} Dy/{sup 166} Ho

    Energy Technology Data Exchange (ETDEWEB)

    Pedraza L, M

    2006-07-01

    The importance of this original research lies in the fact that it has proven that the [{sup 166}Dy]Dy/{sup 166}Ho-EDTMP in vivo generator system is a stable complex that can be used as a therapeutic radiopharmaceutical. Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. Bone-seeking radiopharmaceuticals such as {sup 166}Ho-DOTMP or {sup 153}Sm-DTMP, have been proposed for delivering ablative radiation doses to marrow in multiple myeloma and other hematological malignancies or have shown excellent results in palliative bone metastasis pain therapy, respectively. As lanthanides have similar chemical characteristics the phosphonate with bone affinity (EDTMP) labeled with Dy/Ho can be used for marrow ablation while causing minimal irradiation to normal organs. This in vivo generator system has not been previously reported. The aim of this research was to label EDTMP (ethylene diamine tetramethylene phosphonate) with {sup 166}Dy/{sup 166}Ho; to evaluate the in vitro and in vivo stability of both {sup 166}Dy-EDTMP and {sup 166}Ho-EDTMP complexes when the daughter {sup 166}Ho is formed as a dysprosium decay product; to determine the bone marrow cytotoxic and genotoxic effect in mice and to evaluate, by histopathology, the myeloablative potential of the [{sup 166}Dy]Dy/{sup 166}Ho-EDTMP in vivo generator system. {sup 166}Dy was obtained by neutron irradiation of enriched {sup 164}Dy{sub 2}O{sub 3} in a TRIGA Mark III reactor. Labeling was carried out in an aqueous phosphate medium at pH 8.0 by addition of {sup 166}DyCl{sub 3} to EDTMP at a molar ratio 1:1.75, with >99 % radiochemical purity, as determined by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). In vitro studies demonstrated that {sup 166}Dy/{sup 166}Ho-EDTMP is unstable after dilution in saline but stable in human serum with no translocation of the daughter nucleus

  10. The use of absorption refrigeration systems in combined cycle power plants; Empleo de sistemas de refrigeracion por absorcion en plantas de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Romero Paredes, H.; Ambriz, J.J.; Vargas, M.; Godinez, M.; Gomez, F.; Valdez, L.; Pantoja, G. [Universidad Autonoma Metropolitana, Unidad Iztapalapa, Departamento de Ingenieria de Procesos e Hidraulica, Mexico D. F. (Mexico)

    1995-12-31

    Day after day the electric power generation tends to be done in the most efficient way in order to diminish the generation costs and the rate of environmental pollution per KWh generated. This paper discusses the application of absorption refrigeration systems for the cooling of the air entering the compressor of a gas turbine in a combined cycle, in order to increase the mass air flow and with it the turbine output. The flows with remanent energy content that are not used in a combined cycle can be used for the operation of the absorption refrigeration system. This way, the required thermal energy for the cooling system is free. With this system it is possible to raise the gas turbine generation output from 5% to 25%. [Espanol] La generacion electrica dia con dia pretende realizarse de la manera mas eficiente posible con el objeto de disminuir los costos de generacion y la tasa de contaminacion ambiental por Kwh generado. En el presente trabajo se introduce la aplicacion de sistemas de refrigeracion por absorcion para el enfriamiento del aire de entrada al compresor de la turbina de gas de un ciclo combinado, con el objeto de aumentar el flujo masico del aire y con ello la potencia de salida de la turbina. Las corrientes con contenido remanente de energia termica que no se usan en una planta de ciclo combinado pueden servir para operar el sistema de refrigeracion por absorcion. De esta manera, la energia termica requerida para el sistema de enfriamiento es gratuita. Con este sistema es posible incrementar la potencia de generacion de la turbina de gas de 5 a 25%.

  11. The use of absorption refrigeration systems in combined cycle power plants; Empleo de sistemas de refrigeracion por absorcion en plantas de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Romero Paredes, H; Ambriz, J J; Vargas, M; Godinez, M; Gomez, F; Valdez, L; Pantoja, G [Universidad Autonoma Metropolitana, Unidad Iztapalapa, Departamento de Ingenieria de Procesos e Hidraulica, Mexico D. F. (Mexico)

    1996-12-31

    Day after day the electric power generation tends to be done in the most efficient way in order to diminish the generation costs and the rate of environmental pollution per KWh generated. This paper discusses the application of absorption refrigeration systems for the cooling of the air entering the compressor of a gas turbine in a combined cycle, in order to increase the mass air flow and with it the turbine output. The flows with remanent energy content that are not used in a combined cycle can be used for the operation of the absorption refrigeration system. This way, the required thermal energy for the cooling system is free. With this system it is possible to raise the gas turbine generation output from 5% to 25%. [Espanol] La generacion electrica dia con dia pretende realizarse de la manera mas eficiente posible con el objeto de disminuir los costos de generacion y la tasa de contaminacion ambiental por Kwh generado. En el presente trabajo se introduce la aplicacion de sistemas de refrigeracion por absorcion para el enfriamiento del aire de entrada al compresor de la turbina de gas de un ciclo combinado, con el objeto de aumentar el flujo masico del aire y con ello la potencia de salida de la turbina. Las corrientes con contenido remanente de energia termica que no se usan en una planta de ciclo combinado pueden servir para operar el sistema de refrigeracion por absorcion. De esta manera, la energia termica requerida para el sistema de enfriamiento es gratuita. Con este sistema es posible incrementar la potencia de generacion de la turbina de gas de 5 a 25%.

  12. Genotoxic and cytotoxic damage by the therapeutic radiopharmaceutical [{sup 166}Dy]Dy/{sup 166}Ho-EDTMP as in vivo generator system; Dano genotoxico y citotoxico por el radiofarmaco terpeutico [{sup 166}Dy]Dy/{sup 166}Ho-EDTMP como sistema de generador in vivo

    Energy Technology Data Exchange (ETDEWEB)

    Pedraza L, M; Piedras R, J [Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubiran. Vasco. de Quiroga 15, 14000 Mexico D.F. (Mexico); Ferro F, G; Morales R, P [ININ, Km. 36.5 Carretera Mexico-Toluca, Ocoyoacac, 52045 Estado de Mexico (Mexico); Murphy S, E [Hospital Santaelena, Mexico D.F. (Mexico); Hernandez O, O [Escuela Superior de Fisica y Matematicas, IPN, Mexico D.F. (Mexico)

    2005-07-01

    In patients with leukemias and multiple myeloma, the cure can be obtained to inclination of a bone marrow transplant (m.o.), for that which one is used a combination of external radiotherapy and chemotherapy with the consequent toxicity to healthy organs. The complex [{sup 166}Dy]Dy/{sup 166}Ho-ethylenediaminetetramethylenephosphonate ([{sup 166}Dy]Dy/{sup 166}Ho-EDTMP) it forms a generator system in vivo stable with bony selective likeness in mice therefore, this it could work as a therapeutic radiopharmaceutical for bone marrow ablation. The objective of this original work was to determine the genotoxic and cytotoxic damage produced by the [{sup 166}Dy]Dy/{sup 166}Ho-EDTMP like a generator system in vivo by means of the reticulocytes reduction (RET) and micronucleus elevation in reticulocytes (RET-MN) in peripheral blood and to evaluate its myeloablative potential for histopathologic studies. It was irradiated {sup 166}Dy{sub 2}O{sub 3} enriched and it was add in form {sup 166}DyCI{sub 3} to the EDTMP in a softening media of phosphates (pH 8), the optimal molar relationship {sup 166}Dy: EDTMP was 1.7:1 and the radiochemical purity was evaluated by ITLC. The Dy:EDTMP complexes, non radioactive, its were prepared in the same way with non irradiated dysprosium oxide. A group of BALB/c mice was injected intraperitoneally with the radiopharmaceutical and two groups of control mice were injected with the non radioactive complex and with sodium chloride 0.9% respectively. Before injecting each one of the solutions it was take a basal sample of peripheral blood of the mouse tail and each 48 h post-injection during 12 d. The animals were sacrificed to obtain the organs of interest and to determine the radioactivity in each one. The femur was used for the histopathologic studies. The quantification of the frequency of RET and RET-MN was carried out by flow cytometry of the sanguine samples and the Monte Carlo code MCNP4B for the dosimetry calculations was used. The

  13. Genotoxic and cytotoxic damage by the therapeutic radiopharmaceutical [166Dy]Dy/166Ho-EDTMP as in vivo generator system

    International Nuclear Information System (INIS)

    Pedraza L, M.; Piedras R, J.; Ferro F, G.; Morales R, P.; Murphy S, E.; Hernandez O, O.

    2005-01-01

    In patients with leukemias and multiple myeloma, the cure can be obtained to inclination of a bone marrow transplant (m.o.), for that which one is used a combination of external radiotherapy and chemotherapy with the consequent toxicity to healthy organs. The complex [ 166 Dy]Dy/ 166 Ho-ethylenediaminetetramethylenephosphonate ([ 166 Dy]Dy/ 166 Ho-EDTMP) it forms a generator system in vivo stable with bony selective likeness in mice therefore, this it could work as a therapeutic radiopharmaceutical for bone marrow ablation. The objective of this original work was to determine the genotoxic and cytotoxic damage produced by the [ 166 Dy]Dy/ 166 Ho-EDTMP like a generator system in vivo by means of the reticulocytes reduction (RET) and micronucleus elevation in reticulocytes (RET-MN) in peripheral blood and to evaluate its myeloablative potential for histopathologic studies. It was irradiated 166 Dy 2 O 3 enriched and it was add in form 166 DyCI 3 to the EDTMP in a softening media of phosphates (pH 8), the optimal molar relationship 166 Dy: EDTMP was 1.7:1 and the radiochemical purity was evaluated by ITLC. The Dy:EDTMP complexes, non radioactive, its were prepared in the same way with non irradiated dysprosium oxide. A group of BALB/c mice was injected intraperitoneally with the radiopharmaceutical and two groups of control mice were injected with the non radioactive complex and with sodium chloride 0.9% respectively. Before injecting each one of the solutions it was take a basal sample of peripheral blood of the mouse tail and each 48 h post-injection during 12 d. The animals were sacrificed to obtain the organs of interest and to determine the radioactivity in each one. The femur was used for the histopathologic studies. The quantification of the frequency of RET and RET-MN was carried out by flow cytometry of the sanguine samples and the Monte Carlo code MCNP4B for the dosimetry calculations was used. The radiochemical purity was 99% and in average the specific

  14. Validation of the cleaning and sanitization method for radiopharmaceutical production facilities

    International Nuclear Information System (INIS)

    Robles, Anita; Morote, Mario; Moore, Mariel; Castro, Delcy; Paragulla, Wilson; Novoa, Carlos; Otero, Manuel; Miranda, Jesus; Herrera, Jorge; Gonzales, Luis

    2014-01-01

    A protocol for the cleaning and sanitization method for radiopharmaceutical production facilities has been designed and developed for the inner surface of the hot cells for the production of Sodium Pertechnetate Tc-99m and Sm-153 EDTMP, considering an extreme situation for each hot cell. Cleaning is performed with double-distilled water and sanitation with two disinfectant solutions, 70 % isopropyl alcohol and 3 % hydrogen peroxide in alternate weeks. Microbiological analysis of sanitized surfaces were made after 20 minutes and 48 hours for the hot cell of Tc-99m and 72 hours for the hot cell of EDTMP Sm-153 in 3 consecutive tests by the method of direct contact with plates containing culture medium, made for each sampling point (6 in the first and five in the second). The results showed that the microbial load on surfaces sanitized was below acceptable limits and that the lifetime of cleaning and sanitization is 48 hours for the hot cell of Tc-99m and 72 hours for the one of EDTMP-Sm-153. As a conclusion, the method of cleaning and sanitization is effective to reduce or eliminate microbial contamination therefore, the process is validated. (authors).

  15. Cytotoxic and genotoxic effect of the [{sup 166}Dy]Dy/{sup 166}Ho-EDTMP in vivo generator system in mice

    Energy Technology Data Exchange (ETDEWEB)

    Pedraza-Lopez, Martha [Departamento de Medicina Nuclear, Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubiran, Delegacion Tlalpan, Mexico DF 14000 (Mexico); Ferro-Flores, Guillermina [Instituto Nacional de Investigaciones Nucleares, Carretera Mexico-Toluca, Ocoyoacac, Estado de Mexico, CP 52045 (Mexico); Arteaga de Murphy, Consuelo [Departamento de Medicina Nuclear, Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubiran, Delegacion Tlalpan, Mexico DF 14000 (Mexico)]. E-mail: consuelo_murphy@yahoo.com.mx; Morales-Ramirez, Pedro [Instituto Nacional de Investigaciones Nucleares, Carretera Mexico-Toluca, Ocoyoacac, Estado de Mexico, CP 52045 (Mexico); Piedras-Ross, Josefa [Departamento de Medicina Nuclear, Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubiran, Delegacion Tlalpan, Mexico DF 14000 (Mexico); Murphy-Stack, Eduardo [Hospital Santaelena, Mexico DF (Mexico); Hernandez-Oviedo, Omar [Escuela Superior de Fisica y Matematicas, IPN, Mexico DF (Mexico)

    2004-11-01

    Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. [{sup 166}Dy]Dy/{sup 166}Ho-ethylenediaminetetramethylene phosphonate (EDTMP) forms a stable in vivo generator system with selective skeletal uptake in mice; therefore, it could work as a potential and improved agent for marrow ablation. Induced bone marrow cytotoxicity and genotoxicity are determined by the reduction of reticulocytes (RET) and elevation of micronucleated reticulocyte (MN-RET) in peripheral blood and ablation by bone marrow histological studies. The aim of this study was to determine the bone marrow cytotoxic and genotoxic effect of the [{sup 166}Dy]Dy/{sup 166}Ho-EDTMP in vivo generator system in mice and to evaluate by histopathology its myeloablative potential. Enriched {sup 166}Dy{sub 2}O{sub 3} was irradiated and [{sup 166}Dy]DyCl{sub 3} was added to EDTMP in phosphate buffer (pH 8.0) in a molar ratio of 1:1.75. QC was determined by TLC. Dy-EDTMP complex was prepared the same way with nonirradiated dysprosium oxide. A group of BALB/c mice were intraperitoneally injected with the radiopharmaceutical and two groups of control animals were injected with the cold complex and with 0.9% sodium chloride, respectively. A blood sample was taken at the beginning of the experiments and every 48 h for 12 days postinjection. The animals were sacrificed, organs of interest taken out and the radioactivity determined. The femur was used for histological studies. Flow cytometry analysis was used to quantify the frequency of RET and MN-RET in the blood samples. The MCNP4B Monte Carlo computer code was used for dosimetry calculations. Radiochemical purity was 99% and the mean specific activity was 1.3 MBq/mg. The RET and MN-RET frequency were statistically different in the treatment at the end of the 12-day period demonstrating cytotoxicity and genotoxicity induced by the in vivo generator system. The

  16. Trece tratamientos de la insuficiencia renal aguda secundaria a mieloma múltiple con filtros de high cut off

    Directory of Open Access Journals (Sweden)

    Ana Berni Wennekers

    2016-07-01

    Conclusiones: El tratamiento combinado con quimioterapia más diálisis largas con filtros de HCO resultó eficaz para reducir el nivel de CLLs y recuperar un nivel de función renal suficiente en el 77% de los casos. Con filtros de HCO se consigue un ahorro significativo, en contraposición a lo descrito previamente en la literatura.

  17. Trastorno Somatosensorial en niños con Trastornos por Déficit de Atención con Hiperactividad.

    OpenAIRE

    Romero Ayuso, Dulce María

    2016-01-01

    Introducción: El estudio de los trastornos por déficit de atención (ADHD) se ha centrado en la falta de control inhibitorio como déficit primario, aunque su fisiopatología también se ha relacionado con la corteza somatosensorial. El objetivo de este trabajo fue conocer si existe un trastorno para la discriminación sensorial táctil y praxis en los niños con ADHD y si éste es similar en los subtipos inatento (ADHD-I) y combinado (ADHD-C). Método: los participantes fueron 74 niños entre 7 y 11 a...

  18. Morteros acumuladores con parafinas microencapsuladas para el aprovechamiento de la energía solar en suelos radiantes

    OpenAIRE

    Zetola Vargas, Vicente Andrés

    2013-01-01

    Esta Tesis plantea la pregunta de si el uso de morteros con parafinas microencapsuladas combinado con colectores solares térmicos puede reducir el consumo de energías convencionales, en un sistema tradicional de suelo radiante. Se pretende contribuir al conocimiento acerca del efecto que produce en el edificio, el calor latente acumulado en suelos radiantes, utilizando morteros de cemento Portland con material de cambio de fase (PCM), en conjunto con la energía solar. Para cumplir con este pr...

  19. {sup 177}Lu-EDTMP for palliation of pain from bone metastases in patients with prostate and breast cancer: a phase II study

    Energy Technology Data Exchange (ETDEWEB)

    Agarwal, Krishan Kant; Singla, Suhas; Arora, Geetanjali; Bal, Chandrasekhar [All India Institute of Medical Sciences, Department of Nuclear Medicine, Ansari Nagar, New Delhi (India)

    2015-01-15

    The purpose of this study was to evaluate the efficacy and safety of {sup 177}Lu-EDTMP for pain palliation in patients with bone metastases from castration-resistant prostate and breast cancer. The secondary objective was to compare low-dose and high-dose {sup 177}Lu-EDTMP in bone pain palliation. Included in the study were 44 patients with documented breast carcinoma (12 patients; age 47 ± 13 years) or castration-resistant prostate carcinoma (32 patients; age 66 ± 9 years) and skeletal metastases. Patients were randomized into two equal groups treated with {sup 177}Lu-EDTMP intravenously at a dose of 1,295 MBq (group A) or 2,590 MBq (group B). Pain palliation was evaluated using a visual analogue score (VAS), analgesic score (AS) and Karnofsky performance score (KPS) up to 16 weeks. Toxicity was assessed in terms of haematological and renal parameters. The overall response rate (in all 44 patients) was 86 %. Complete, partial and minimal responses were seen in 6 patients (13 %), 21 patients (48 %) and 11 patients (25 %), respectively. A favourable response was seen in 27 patients (84 %) with prostate cancer and in 11 patients (92 %) with breast cancer. There was a progressive decrease in the VAS from baseline up to 4 weeks (p < 0.05). Also, AS decreased significantly from 1.8 ± 0.7 to 1.2 ± 0.9 (p < 0.0001). There was an improvement in quality of life of the patients as reflected by an increase in mean KPS from 56 ± 5 to 75 ± 7 (p < 0.0001). The overall response rate in group A was 77 % compared to 95 % in group B (p = 0.188). There was a significant decrease in VAS and AS accompanied by an increase in KPS in both groups. Nonserious haematological toxicity (grade I/II) was observed in 15 patients (34 %) and serious toxicity (grade III/IV) occurred in 10 patients (23 %). There was no statistically significant difference in haematological toxicity between the groups. {sup 177}Lu-EDTMP was found to be a safe and effective radiopharmaceutical for bone pain

  20. Empleo del método de secado convectivo combinado para la deshidratación de papaya (Carica papaya L.), variedad Maradol roja

    OpenAIRE

    Sahylin Muñiz Becerá; Antihus Hernández Gómez; Annia García Pereira; Lilia Méndez Lagunas

    2013-01-01

    La presente investigación tiene como objetivo evaluar el método de secado convectivo de papaya (Carica papaya L.) variedad Maradol roja, combinado con la aplicación de pretratamientos de osmosis (DOSC) y escaldado simple (ESSC), mediante el efecto de los factores tecnológi- cos del secador: temperatura (40 y 60oC) y velocidad del flujo de aire (2,5 y 1,5 m/s) sobre el comportamiento de las propiedades de calidad de la fruta deshidratada y la cinética del proceso. El pretratamiento de escaldad...

  1. Crecimiento de Casuarina equisetifolia (Casuarinaceae en suelo con diésel, y aplicación de bioestimulación y bioaumentación

    Directory of Open Access Journals (Sweden)

    María Esther Díaz-Martínez

    2013-09-01

    Full Text Available La fitorremediación es una biotecnología ecológicamente racional que está dirigida a la limpieza de suelos contaminados; sin embargo, el estudio de especies arbóreas para la fitorremediación de suelos con hidrocarburos del petróleo es limitado. Más aún, la combinación de la fitorremediación con procesos de bioaumentación y bioestimulación es también limitada. Por lo anterior, este estudio evaluó el efecto de la inoculación de Glomus intraradices, un consorcio bacteriano (M2BOS1-R2 y M2BOSI-F4 y Trichoderma viride en el crecimiento de plantas de Casuarina equisetifolia L. fertilizadas con Floranid® o Triple 17, en suelo contaminado con diésel (7 500mg/kg. El experimento factorial 2x5x3 incluyó 30 tratamientos y 10 repeticiones, distribuidos completamente al azar en invernadero, durante 120 días. El diésel disminuyó significativamente la altura, la biomasa total y el índice de calidad (ICP de planta. Glomus o las bacterias aumentaron significativamente la altura, la biomasa seca total y el ICP con respecto al tratamiento sin inocular o con la triple inoculación. El Floranid redujo el crecimiento vegetal y el ICP, en presencia de diésel. El Triple 17 combinado con los tres microorganismos produjo mayor crecimiento vegetal en ausencia de contaminación, pero en presencia de diésel, el Triple 17 combinado con bacterias o con Trichoderma, estimuló la biomasa seca total y el ICP. La colonización micorrízica fue inhibida por el diesel, especialmente con la fertilización del Floranid. El Triple 17 (bioestimulación combinado con los microorganismos (bioaumentación, favoreció el crecimiento de Casuarina en suelo contaminado con diésel.

  2. Efeito do treinamento combinado e aeróbio no controle glicêmico no diabetes tipo 2

    Directory of Open Access Journals (Sweden)

    Antônio Renato Pereira Moro

    Full Text Available INTRODUÇÃO: O diabetes tipo 2 é um grupo heterogêneo de doença metabólica causada por uma disfunção na secreção da insulina e/ou ação desta. OBJETIVOS: Comparar o efeito de duas modalidades de treinamento, o combinado (aeróbio e resistido e o aeróbio, no controle glicêmico no diabetes tipo 2. MATERIAIS E MÉTODOS: A pesquisa caracteriza-se por ser um estudo quase-experimental. Após aprovação do CEP, com registro 09.071.4.08. III, deu-se início ao programa de treinamento combinado e aeróbio. Foram selecionados 24 participantes, de ambos os gêneros, sedentários, com média de idade de 60,41 ± 7,87. Os participantes foram divididos aleatoriamente em dois grupos: treinamento combinado (n = 12 e treinamento aeróbio (n = 12; ambos foram avaliados no início e final do estudo. A concentração sérica de glicose foi determinada pelo sistema Vitros e a hemoglobina glicosilada foi determinada pelo método Cromatografia Líquida de Alta Performance. O treinamento foi realizado três vezes por semana, com duração total de 20 semanas. Os dados são expressos em média e desvio-padrão. Foi aplicado o teste t pareado (p < 0,05 para comparar a média basal e após 20 semanas de treinamento. RESULTADOS: A média da glicose em jejum do treinamento combinado reduziu significativamente, de 167,41 ± 38,13 para 119,83 ± 20,91, sendo que o mesmo ocorreu com o treinamento aeróbio de 189,83 ± 63,57 para 139,91 ± 34,04. Os valores da hemoglobina glicosilada no treinamento combinado e treinamento aeróbio reduziram significativamente, de 8,61 ± 1,17 para 7,25 ± 1,24 e de 9,52 ± 2,46 para 8,37 ± 1,50, respectivamente. CONCLUSÃO: O treinamento combinado foi mais eficaz em relação à hemoglobina glicosilada e o treinamento aeróbio, na glicose plasmática.

  3. Structure–function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the yeast Sm protein ring

    Science.gov (United States)

    Schwer, Beate; Kruchten, Joshua; Shuman, Stewart

    2016-01-01

    A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing. Using human snRNP structures to guide mutagenesis in Saccharomyces cerevisiae, we gained new insights into structure–function relationships of the SmG, SmE, and SmF subunits. An alanine scan of 19 conserved amino acids of these three proteins, comprising the Sm RNA binding sites or inter-subunit interfaces, revealed that, with the exception of Arg74 in SmF, none are essential for yeast growth. Yet, for SmG, SmE, and SmF, as for many components of the yeast spliceosome, the effects of perturbing protein–RNA and protein–protein interactions are masked by built-in functional redundancies of the splicing machine. For example, tests for genetic interactions with non-Sm splicing factors showed that many benign mutations of SmG, SmE, and SmF (and of SmB and SmD3) were synthetically lethal with null alleles of U2 snRNP subunits Lea1 and Msl1. Tests of pairwise combinations of SmG, SmE, SmF, SmB, and SmD3 alleles highlighted the inherent redundancies within the Sm ring, whereby simultaneous mutations of the RNA binding sites of any two of the Sm subunits are lethal. Our results suggest that six intact RNA binding sites in the Sm ring suffice for function but five sites may not. PMID:27417296

  4. Déficit en Habilidades Sociales en Niños con Trastorno por Déficit de Atención- Hiperactividad, Evaluados con la Escala BASC

    Directory of Open Access Journals (Sweden)

    PEDRO PUENTES ROZO

    2014-01-01

    Full Text Available Se analizaron las Habilidades Sociales ( HS de 159 niños de ambos sexos, escolarizados, con Trastorno por Déficit de Atención-Hiperactividad ( TDAH , entre los 6 y los 11 años de edad. La valo - ración de las HS se realizó con la escala Behavioral Assessment System for Children para padres y maestros. Los resultados mostraron que los niños con TDAH presentan puntajes más bajos en las dimensiones de habilidades sociales como escu - char, esperar turnos, reconocer señales sociales y tener capacidad de adaptabilidad. Sin embargo, en compañerismo, los participantes con TDAH combinado poseen habilidades semejantes a los no afectados. Esto replantea lo encontrado en la mayoría de los estudios en donde únicamente se evidencian deficiencias.

  5. Structure-function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the yeast Sm protein ring.

    Science.gov (United States)

    Schwer, Beate; Kruchten, Joshua; Shuman, Stewart

    2016-09-01

    A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing. Using human snRNP structures to guide mutagenesis in Saccharomyces cerevisiae, we gained new insights into structure-function relationships of the SmG, SmE, and SmF subunits. An alanine scan of 19 conserved amino acids of these three proteins, comprising the Sm RNA binding sites or inter-subunit interfaces, revealed that, with the exception of Arg74 in SmF, none are essential for yeast growth. Yet, for SmG, SmE, and SmF, as for many components of the yeast spliceosome, the effects of perturbing protein-RNA and protein-protein interactions are masked by built-in functional redundancies of the splicing machine. For example, tests for genetic interactions with non-Sm splicing factors showed that many benign mutations of SmG, SmE, and SmF (and of SmB and SmD3) were synthetically lethal with null alleles of U2 snRNP subunits Lea1 and Msl1. Tests of pairwise combinations of SmG, SmE, SmF, SmB, and SmD3 alleles highlighted the inherent redundancies within the Sm ring, whereby simultaneous mutations of the RNA binding sites of any two of the Sm subunits are lethal. Our results suggest that six intact RNA binding sites in the Sm ring suffice for function but five sites may not. © 2016 Schwer et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  6. Validez de un modelo reducido de ítems del DSM-IV según respuesta de padres y profesores en el diagnóstico del Trastorno por Déficit de Atención con Hiperactividad Combinado

    Directory of Open Access Journals (Sweden)

    José Antonio López-Villalobos

    2014-10-01

    Full Text Available Objetivo: Buscar un modelo reducido de síntomas del Trastorno por Déficit de Atención con Hiperactividad subtipo Combinado (TDAH-C, que presente adecuada validez de criterio para su diagnóstico. Metodología: Contexto de estudio epidemiológico. Muestra de 1095 casos entre 6 y 16 años [4.38 % TDAH-C]. Selección de casos con primera fase psicométrica de sospecha TDAH-C que requiere que ADHD RS-IV, implementado por padres (PA y profesores (PR, supere el PC 90. Segunda fase: Los casos seleccionados se evalúan mediante entrevista clínica modelo DISC-IV (DSM-IV para confirmar TDAH-C. Se implementa regresión logística para buscar modelo parsimonioso de ítems que permita predecir TDAH-C. Resultados: El modelo de ítems que permite predecir TDAH-C contiene 8 de los 36 ítems del ADHD RS-IV contestados por PA y PR. Considerando las odds ratio del modelo de regresión logística, los ítems del ADHD RS-IV seleccionados son los siguientes 15PR, 1PA, 16PR, 12PA, 17PA, 10PA, 14PA y 4PR. El modelo presenta validez de criterio para TDAH-C clínico (sensibilidad: 97.9 %. Especificidad: 93.8%. Razón de verosimilitud: 16.02. Conclusiones: Es posible reducir la lista de síntomas de TDAH-C con buena validez de criterio, manteniendo los que proporcionan mayor discriminación entre TDAH-C y población general.

  7. Problema de Localización y Ruteo con Restricciones de Capacidad: Revisión de la Literatura

    Directory of Open Access Journals (Sweden)

    John Willmer Escobar

    2015-05-01

    Full Text Available En este artículo se hace una revisión exhaustiva del estado del arte de las metodologías de solución existentes para el problema combinado de localización y ruteo con restricciones de capacidad (CLRP. El problema de CLRP tiene una gran cantidad de aplicaciones prácticas en temas relacionados con transporte. Se ha propuesto el siguiente esquema de clasificación de acuerdo al método de solución: (1 Algoritmos Heurísticos Constructivos, (2 Algoritmos Heurísticos Basados en Clústeres, (3 Algoritmos Heurísticos Basados en Trayectoria, (4 Algoritmos Heurísticos Basados en Población, (5 Algoritmos Heurísticos Combinados, (6 Métodos Exactos. Se hace especial énfasis en fortalezas y debilidades de cada metodología publicada, identificando oportunidades de investigación y desarrollo en el área, en el contexto de la aplicación práctica de la problemática.

  8. Producción de carbones ultralimpios usando flotación burbujeante y lixiviación con ácidos

    Directory of Open Access Journals (Sweden)

    Juan Barraza

    2009-01-01

    Full Text Available Los carbones ultralimpios representan una importante materia prima para la elaboración de productos de alto valor agregado tales como fibra de carbono, electrodos, espumas de carbón, entre otros. En este trabajo, carbones ultralimpios con concentraciones menores a 0,50% de ceniza (p/p, base seca, bs se obtuvieron usando flotación burbujeante en columna y lixiviación con ácidos fluorhídrico (HF y nítrico (HNO3. Los contenidos de ceniza se redujeron desde 19,60 % en los carbones alimentados hasta 8,70 % en los carbones flotados usando tres etapas en serie en una columna de flotación. Al usar lixiviación química con HF 7,53M y HNO3 2,3M, los carbones presentaron contenidos de 1,42% de ceniza, 0,86% de azufre y 2,00% de materia mineral, mientras que cuando se usó un proceso combinado de flotación seguido de lixiviación ácida con HF 19,2M y HNO3 8,12M se obtuvo un carbón con 0,48 % de ceniza 0,71 % de azufre y 0,96 % de materia mineral. Sin embargo, al usar carbón original (no flotado a las mismas concentraciones ácidas utilizadas en el proceso combinado se produjo un carbón ultralimpio de contenido de ceniza 0,33%.

  9. Diferencias en ansiedad estado-rasgo y en atención selectiva en Trastorno por Déficit de Atención con Hiperactividad (TDAH

    Directory of Open Access Journals (Sweden)

    Paloma González-Castro

    2015-01-01

    Full Text Available Uno de los trastornos que más afecta al rendimiento escolar es el Trastorno por Déficit de Atención con Hiperactividad (TDAH. El criterio establecido por el DSM diferencia tres subtipos: inatento, hiperactivo-impulsivo y combinado. Sin embargo, el perfil de este trastorno podría verse alterado por la asociación con otros como la ansiedad. El objetivo de esta investigación es determinar si hay diferentes patrones de atención (selectiva y sostenida y ansiedad (estado y rasgo en los tres subtipos de TDAH. Además, el objetivo es analizar cómo la ansiedad predice el rendimiento de los estudiantes con TDAH en una tarea de atención selectiva. La muestra estaba formada por 220 estudiantes (6-12 años: 56 en el grupo control, 54 con TDAH-Inatento, 53 con TDAH-Hiperactivo impulsivo y 56 con el subtipo combinado. Los resultados obtenidos mostraron que los cuatro grupos resultaban significativamente diferentes en las variables atencionales y en los niveles de ansiedad estado y rasgo. Al mismo tiempo, la ansiedad rasgo predijo el rendimiento en la variable de concentración analizada. Los resultados revelan un nuevo patrón de gran interés de cara a la evaluación diagnóstica objetiva y fiable en el TDAH.

  10. desenvolvimento desigual e combinado

    Directory of Open Access Journals (Sweden)

    Sonia Maria Rummert

    2013-01-01

    Full Text Available El propósito de este artículo es explicitar el efecto de sentido y el carácter funcional de la composición constituida hoy, en Brasil, por el expresivo conjunto de iniciativas dirigidas a la educación y formación de la clase trabajadora. Para alcanzar los fines del análisis propuesto, presentamos consideraciones respecto a los conceptos de capital- imperialismo y desarrollo desigual y combinado, así como de sus expresiones en Brasil y, particularmente, en la educación y formación de la clase trabajadora. De esa manera, seintenta evidenciar cómo se gestan, en el escenario del capital-imperialismo subalterno, nuevas formas de destitución del derecho al acceso universal al conocimiento científico y tecnológico. Finalmente, examinamos el conjunto de programas y acciones emprendidas por el gobierno federal, desde la década de 1990, y los presentamos reunidos de acuerdo a las características identificadas como portadoras de similitudes.

  11. Corrección de la clorosis férrica con quelato EDDHA en cultivos sembrados en suelo alcalino y calcáreo

    Directory of Open Access Journals (Sweden)

    Arturo Díaz Franco

    2018-01-01

    Full Text Available La deficiencia de hierro (Fe en los cultivos se manifiesta principalmente en regiones con suelos alcalinos y calcáreos. En el presente estudio se evaluó la efectividad del Fe3+ quelatado con EDDHA [ac. etilendiamino di-(o-hidroxifenilacetato] y la aspersión foliar de FeSO4 solos y combinados, en los cultivos de sorgo, soya, okra y frijol. El EDDHA-Fe (Ultraferro® se aplicó a dosis de 1% en la siembra sobre las semillas y para el FeSO4 se hicieron dos aplicaciones foliares al 1.5%. En los cuatro experimentos se determinó el índice de clorofila (SPAD en tres fechas (15 y 28 de marzo, 6 de abril, y a los 48-50 días después de la siembra se cuantificó la biomasa foliar y radical. Entre los cultivos, las plantas de soya y okra manifestaron la mayor intensidad de clorosis férrica, la cual fue visible entre los tratamientos. En ambos cultivos los mayores valores SPAD y de biomasa foliar y radical se obtuvieron con la aplicación de EDDHA-Fe solo o combinado con FeSO4. En frijol y sorgo, la clorosis fue menos visible, para las plantas de frijol el mayor índice de clorofila se registró con EDDHA-Fe y FeSO4 en las dos últimas fechas de evaluación (28 de marzo y 6 de abril y los tres tratamientos químicos superaron de forma similar al testigo, en la biomasa foliar y radical. Las plantas de sorgo registraron los mayores índices SPAD en la última fecha (6 de abril, mientras que no fueron significativas las diferencias en la biomasa foliar y radical. No se observó efecto aditivo en las variables con la combinación EDDHA-Fe y FeSO4. En general, los resultados indican que la aplicación de EDDHA-Fe solo o combinado con FeSO4 foliar en soya, okra y frijol, mostraron corrección de la clorosis férrica de manera efectiva.

  12. Síndrome metabólico y su relación con hipogonadismo tardío

    Directory of Open Access Journals (Sweden)

    Dra. A. Verónica Araya Q.

    2014-01-01

    Conclusiones: En todo paciente con un hipogonadismo demostrado se debe buscar elementos del SM pero, en los pacientes con SM o DM2, la medición de T se debe considerar sólo si hay otros elementos clínicos que orienten a una deficiencia de andrógenos. En cuanto a la indicación de terapia de reemplazo en los pacientes diabéticos o con SM, aún faltan estudios controlados, a largo plazo que evalúen los beneficios reales, metabólicos y cardiovasculares. Lo fundamental en estos pacientes es la prevención, promoviendo un estilo de vida saludable.

  13. UTILIDAD DEL PERÍMETRO ABDOMINAL COMO MÉTODO DE CRIBAJE DEL SÍNDROME METABÓLICO EN LAS PERSONAS CON HIPERTENSIÓN ARTERIAL

    Directory of Open Access Journals (Sweden)

    Roberto Genique Martínez

    2010-01-01

    Full Text Available Fundamento: Para el diagnóstico de Síndrome Metabólico (SM los criterios mas utilizados son los propuestos, por el ATP-III del NCEP de 2001, actualizados posteriormente en 2005. El perímetro de cintura es uno de los cinco criterios utilizados para su diagnóstico. Dada la elevada incidencia ajustada de enfermedad coronaria atribuible a este factor de riesgo, el objetivo de este trabajo es valorar la utilidad del perímetro de cintura como método de cribaje único de SM en la población con otros factores de riesgo muy prevalentes, como la HTA. Método: Estudio de casos (pacientes hipertensos con SM y controles (pacientes hipertensos sin SM. Mediante muestreo sistemático de la totalidad de individuos hipertensos de un cupo de Atención Primaria con resultados de al menos una analítica sanguínea desde el 1/07/2007 hasta 31/12/2007. El tamaño muestral fue de 137 individuos (casos = pacientes hipertensos con SM = 60 y controles = pacientes hipertensos sin SM=77. Se utilizó el test de regresión logística para el cálculo de la probabilidad de SM disponiendo únicamente del perímetro abdominal. Resultados: Los resultados para el objetivo principal fueron: Probabilidad de SM en población hipertensa=1/(1+2,718281828-(-10+ (perímetro x 0,097, Probabilidad de SM en mujeres hipertensas=1/ (1+2,718281828-(-10+ (perímetro x 0,099, Probabilidad de SM en varones hipertensos=1/(1+2,718281828-(-10+ (perímetro x 0,105. Conclusiones: Utilizando una calculadora podría predecirse la probabilidad de SM en personas hipertensas con el perímetro de cintura como única variable, priorizando mejor a los pacientes con más necesidad preventiva y mayor riesgo cardiovascular. Se propone una tabla con los cálculos ya realizados.

  14. SIMULACIÓN HORARIA DE UN SISTEMA DE REFRIGERACIÓN COMBINADO EYECTOR-COMPRESIÓN DE VAPOR ASISTIDO POR ENERGÍA SOLAR Y GAS NATURAL HOURLY SIMULATION OF A COMBINED EJECTOR-VAPOR COMPRESSION REFRIGERATION SYSTEM ASSISTED BY SOLAR ENERGY AND NATURAL GAS

    Directory of Open Access Journals (Sweden)

    Humberto Vidal

    2009-04-01

    Full Text Available Entre los sistemas de refrigeración movidos térmicamente asistidos por energía solar y gas natural, el sistema de refrigeración con eyector ha recibido especial atención. Este sistema se caracteriza por su simplicidad constructiva, ausencia de partes móviles, operación en bajas temperaturas y bajo costo operacional. Sin embargo, el ciclo de refrigeración por eyector tiene usualmente un bajo coeficiente de desempeño. Una alternativa de solución a este problema lo constituye el sistema de refrigeración con eyector combinado. La primera etapa está constituida por un ciclo de compresión mecánica de vapor convencional con R134a, mientras que la segunda etapa la constituye un ciclo termo-movido con eyector usando R141b como fluido de trabajo. Colectores de placa plana y un quemador de energía auxiliar entregan calor al ciclo de eyector. Este artículo describe la simulación en base horaria de un sistema de refrigeración combinado eyector-compresión de vapor asistido por energía solar y gas natural. El sistema de refrigeración solar combinado es modelado usando la herramienta de simulación TRNSYS-EES y los datos climáticos de un año típico de Florianópolis, Brasil. Los resultados obtenidos con la modelación computacional desarrollada para este sistema muestran la ventaja del ciclo de refrigeración combinado eyector-compresión de vapor por sobre el ciclo simple con eyector. Finalmente, el modelo computacional desarrollado en este artículo podría ser usado para realizar una optimización termo-económica del sistema en trabajos futuros.Among the thermally driven cooling systems assisted by solar energy and natural gas, the ejector cooling system has received special attention. This system is an interesting refrigeration technology due to its construction simplicity, absence of moving parts, operation at lower temperatures and a low operational cost. However, the coefficient of performance of ejector cycle is usually low. The

  15. New aspects of radionuclide therapy of bone and joint diseases

    International Nuclear Information System (INIS)

    Fischer, M.

    2001-01-01

    Whereas in developing countries P-32 is widely used for radionuclide therapy of painful bone metastases, in Europe three radionuclides or radiopharmaceutical agents are available for pain palliation: Sr-89, Sm-153-EDTMP, and Re-186-HEDP. Radionuclide therapy for pain palliation is indicated for bone pain due to metastatic malignancy that has involved multiple skeletal sites and has evoked an osteoblastic response on bone scintigraphy. Response rates of about 70-80% in patients with breast or prostate cancer is reported in the literature, less in metastatic lesions of other primary malignancies. Sm-153-EDTMP may also be used for curative treatment of primary bone tumours or their metastases. Radiosynovectomy as therapeutic procedure or rheumatoid arthritis, other inflammatory joint diseases, persistent synovial perfusion, and other joint diseases is widely used. Using Y-90 for the knee joint, Re-186 for middle sized joints, and Er-169 for small joints an improvement of symptoms may be observed in about 70-80%. (author)

  16. Radiopharmaceuticals developed at the University of Missouri research reactor

    International Nuclear Information System (INIS)

    Ketring, A.R.; Ehrhardt, G.J.; Day, D.E.

    1997-01-01

    The University of Missouri Research Reactor (MURR) has put a great deal of effort in the last two decades into development of radiotherapeutic beta emitters as nuclear medicine radiotherapeutics for malignancies. This paper describes the development of two of these drugs, 153 Sm ethylenediaminetetra-methylene phosphonic acid (EDTMP) (Quadramet trademark) and 90 Y glass microspheres (TheraSphere trademark). Samarium-153 EDTMP is a palliative used to treat the pain of metastatic bone cancer without the side effects of narcotic pain killers. Yttrium-90 glass microspheres are delivered via hepatic artery catheter to embolize the capillaries of liver tumors and deliver a large radiation dose for symptom palliation and life prolonging purposes

  17. Radiation damage in SmS, SmSsub(1-x)Psub(x) and SmB6

    International Nuclear Information System (INIS)

    Morillo, J.; Bordier, G.; de Novion, C.H.; Senateur, J.P.; Jun, J.

    1984-08-01

    Large conductivity increases under 21 K electron or neutron irradiations are observed in SmS and SmSsub(1-x)Psub(x). It is shown that they are related to Sm defects. A possible mechanism is 4f electron delocalization around radiation defects. In SmB 6 , the low temperature resistivity increase desappears under 21 K irradiation. The thermal stability of the defects is also investigated up to room temperature

  18. Propuestas para el entrenamiento combinado de fuerza y resistencia

    OpenAIRE

    López de Viñaspre, Pablo; Comellas, Josep

    2000-01-01

    Muchas especialidades deportivas requieren de un buen nivel de entrenamiento tanto en la capacidad de fuerza como en la de resistencia. Por este motivo, se incluye el entrenamiento combinado de estas dos cualidades en el programa de entrenamiento de muchos deportistas. Por otro lado, en el deporte recreativo, el concepto del Fitness es ya común entre la mayoría de la población y va tomando cada vez más importancia. Actualmente se busca el bienestar global (tendencia del Wellness) a través de ...

  19. Strategy for Bone Metastases Treatment in Patients with Impending Cord Compression or Vertebral Fractures: A Pilot Study

    International Nuclear Information System (INIS)

    Rasulova, N.; Lyubshin, V.; Djalalov, F.; Kim, K. H.; Nazirova, L.; Ormanov, N.; Arybzhanov, D.

    2011-01-01

    Impending spinal cord compression and vertebral fractures are considered contraindications for radionuclide bone pain palliation therapy. However, most of the patients with widespread bone metastases already have weakened vertebral segments that may be broken. Therefore, local field external-beam radiotherapy or percutaneous vertebroplasty (VP) should be considered to improve the patient's quality of life and to institute subsequent appropriate treatment, including radionuclide therapy for bone pain palliation. The objective of this study was to develop a strategy for an effective treatment of bone metastases in patients with widespread bone metastases and intolerable pain, associated with impending cord compression or vertebral fractures. Eleven patients (5 females and 6 males, aged 32-62 years; mean age 53.8 ± 2.7 years) with multiple skeletal metastases from carcinomas of prostate (n = 3), breast (n = 3) and lung (n = 5) were studied. Their mean pain score measured on a visual analogue scale of 10 was found to be 8.64 ± 0.15 (range 8-9) and the mean number of levels with impending cord compression or vertebral fracture was 2.64 ± 0.34 (range 1–4). All patients underwent vertebroplasty and after 3–7 days received Sm-153 ethylene diamine tetra methylene phosphonic acid (EDTMP) therapy. Sm-153 EDTMP was administered according to the recommended standard bone palliation dose of 37 MBq/kg body weight. Whole body (WB) bone scan, computed tomography and magnetic resonance imaging (MRI) were performed before and after treatment in all patients. Pain relief due to stabilization of vertebrae after VP occurred within the first 12 hours (mean 4.8 ± 1.2 hours; range 0.5–12 hours), and the mean pain score was reduced to 4.36 ± 0.39 (range 2–6). Subsequent to Sm-153 EDTMP treatment, further pain relief occurred after 3.91 ± 0.39 days (range 2-6 days) and the pain score decreased to 0.55 ± 0.21 (range 0–2). The responses to treatment were found to be

  20. Radiopharmaceuticals developed at the University of Missouri research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Ketring, A.R.; Ehrhardt, G.J. [Univ. of Missouri, Columbia, MO (United States); Day, D.E. [Univ. of Missouri, Rolla, MO (United States)

    1997-12-01

    The University of Missouri Research Reactor (MURR) has put a great deal of effort in the last two decades into development of radiotherapeutic beta emitters as nuclear medicine radiotherapeutics for malignancies. This paper describes the development of two of these drugs, {sup 153}Sm ethylenediaminetetra-methylene phosphonic acid (EDTMP) (Quadramet{trademark}) and {sup 90}Y glass microspheres (TheraSphere{trademark}). Samarium-153 EDTMP is a palliative used to treat the pain of metastatic bone cancer without the side effects of narcotic pain killers. Yttrium-90 glass microspheres are delivered via hepatic artery catheter to embolize the capillaries of liver tumors and deliver a large radiation dose for symptom palliation and life prolonging purposes.

  1. Control inhibitorio y monitorización en población infantil con TDAH

    Directory of Open Access Journals (Sweden)

    Carlos Ramos

    2017-02-01

    Full Text Available El trastorno por déficit de atención con hiperactividad (TDAH ha sido asociado a déficits de las funciones ejecutivas, sin embargo, aún no existe claridad respecto a cuál es el perfil cognitivo en el subtipo combinado (TDAH-C. Los objetivos de este estudio fueron comparar el control inhibitorio y la monitorización de estudiantes con y sin TDAH-C, y analizar la correlación entre tareas experimentales y escalas comportamentales de evaluación de las funciones ejecutivas mencionadas. El estudio tuvo 68 participantes, quienes conformaron un grupo experimental de 34 estudiantes con TDAH-C y un grupo control de 34 estudiantes con desarrollo típico. Los instrumentos de medición fueron las escalas comportamentales BRIEF, BIS 11-c y ADHD Rating Scale IV, y los experimentos Go/No-Go, Simon y Stroop Victoria. Se encontró que el grupo experimental con TDAH presenta déficits en las funciones ejecutivas evaluadas, y que las escalas comportamentales y los experimentos evalúan diferentes niveles del funcionamiento ejecutivo.

  2. Search for a SM Higgs boson in dilepton plus missing transverse ...

    Indian Academy of Sciences (India)

    2012-11-11

    Nov 11, 2012 ... Abstract. A search is presented for the Standard Model (SM) Higgs boson optimized in the decay channel H → W+W−. , where both W bosons decay leptonically. The final state considered con- tains dileptons and missing transverse energy from the neutrinos. A multivariate analysis is used to suppress the ...

  3. Investigation of complexes with bone affinity using the In vivo generator system 166 Dy/166 Ho

    International Nuclear Information System (INIS)

    Pedraza L, M.

    2006-01-01

    The importance of this original research lies in the fact that it has proven that the [ 166 Dy]Dy/ 166 Ho-EDTMP in vivo generator system is a stable complex that can be used as a therapeutic radiopharmaceutical. Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. Bone-seeking radiopharmaceuticals such as 166 Ho-DOTMP or 153 Sm-DTMP, have been proposed for delivering ablative radiation doses to marrow in multiple myeloma and other hematological malignancies or have shown excellent results in palliative bone metastasis pain therapy, respectively. As lanthanides have similar chemical characteristics the phosphonate with bone affinity (EDTMP) labeled with Dy/Ho can be used for marrow ablation while causing minimal irradiation to normal organs. This in vivo generator system has not been previously reported. The aim of this research was to label EDTMP (ethylene diamine tetramethylene phosphonate) with 166 Dy/ 166 Ho; to evaluate the in vitro and in vivo stability of both 166 Dy-EDTMP and 166 Ho-EDTMP complexes when the daughter 166 Ho is formed as a dysprosium decay product; to determine the bone marrow cytotoxic and genotoxic effect in mice and to evaluate, by histopathology, the myeloablative potential of the [ 166 Dy]Dy/ 166 Ho-EDTMP in vivo generator system. 166 Dy was obtained by neutron irradiation of enriched 164 Dy 2 O 3 in a TRIGA Mark III reactor. Labeling was carried out in an aqueous phosphate medium at pH 8.0 by addition of 166 DyCl 3 to EDTMP at a molar ratio 1:1.75, with >99 % radiochemical purity, as determined by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). In vitro studies demonstrated that 166 Dy/ 166 Ho-EDTMP is unstable after dilution in saline but stable in human serum with no translocation of the daughter nucleus subsequent to β decay of 166 Dy, which could release free 166 Ho 3+ . Biodistribution in mice

  4. Impact of educational strategies in positioning Samarium-153 EDTMP as a treatment for metastatic bone pain

    International Nuclear Information System (INIS)

    Seminario, C.; Morales, R.; Castro, M.; Cano, R.A.; Mendoza, G.

    2005-01-01

    To educate is a difficult task but its results make efforts worthwhile. Many patients in Peru suffer from intractable bone pain due to metastases. Since 1993 radionuclides were used to palliate bone pain due to metastases in Peru. First, with the help of the IAEA, Peru participated in a clinical trial using Phosphorus 32 and Strontium 89. Then, efforts were performed to produce Samarium 153 EDMTP locally, which was achieved in 1995. Nevertheless, years passed and Samarium use did not increase proportionally to the needs of people with cancer and bone pain, mainly the poor. Educational strategies have been proven useful for delivering solutions to many health problems in other diseases and also in cancer. Health education makes patients and their relatives assume responsible care of their problems. The purpose of this work was to increase Samarium EDTMP use as palliative treatment in patients with bone pain due to metastases, using educational strategies as means to change attitudes towards this health problem. In September 2003, a task group conducted studies in order to apply several methods to achieve the goal of increasing Samarium EDTMP use. Educational strategies employed were performed to provide verbal and written information to patients, physicians, medical students, residents, pain specialists, oncologists and neurologists, as well as general public. Verbal information included radio interviews, television spots and a phone number (in charge of two secretaries, prepared for answering and if not possible, a physician was in charge of attending patient consultation), e-mail and a web page for consultation. Written material was delivered to several newspapers, including clinical use of Samarium, possibilities of being elected for treatment, benefits and risks and a photography of the product. Politics of the institution producing Samarium changed, in order to achieve minimum cost of the product and it was delivered to all publics at the lowest cost for a year

  5. Control Neuronal Combinado para Generar Espectros de Oleajes

    Directory of Open Access Journals (Sweden)

    Luis P. Sánchez Fernández

    2013-10-01

    Full Text Available Resumen: Se presenta un método novedoso para controlar la obtención de espectros de energía de oleajes, de gran utilidad en los laboratorios de investigación y desarrollo de Hidráulica Marítima. El elemento final de control o manipulador es un motor eléctrico lineal conectado a un servo-control el cual es supervisado mediante una computadora. El algoritmo de control automático se realiza con un esquema neuronal combinado, compuesto por una red neuronal artificial “feed-forward” y un controlador proporcional integral. El sistema computacional implementado incluye características de autoaprendizaje, materializado en el re-entrenamiento en línea de la red neuronal lo cual hace posible adaptarse a cambios en los parámetros del “proceso controlado” y a perturbaciones, altamente influyentes en el espectro de energía que impacta una obra hidráulica objeto de estudio. Abstract: A novel method is presented to control the generation of wave energy spectrum, useful in research and development laboratories of Maritime Hydraulic. The final control element is a linear electric motor connected to a servo-control which is monitored by a computer. The automatic control algorithm is performed with a combined neural scheme. It consists of an artificial neural network “feed-forward” and a proportional integral controller. The computer system includes self-learning based on an online training of the neural network. It makes possible to adapt to changes in the parameters of the “controlled process” and disturbances that impact the studied hydraulic work. Palabras clave: Control, neuronal, oleaje, espectros, hidráulica, Keywords: Control, neural, wave, spectrums, hydraulic

  6. Optimal Timing of Bisphosphonate Administration in Combination with Samarium-153 Oxabifore in the Treatment of Painful Metastatic Bone Disease

    International Nuclear Information System (INIS)

    Rasulova, Nigora; Lyubshin, Vladimir; Arybzhanov, Dauranbek; Sagdullaev, Sh.; Krylov, Valery; Khodjibekov, Marat

    2013-01-01

    While bisphosphonates are indicated for prevention of skeletal-related events, radionuclide therapy is widely used for treatment of painful bone metastases. Combined radionuclide therapy with bisphosphonates has demonstrated improved effectiveness in achieving bone pain palliation in comparison to mono therapy with radionuclides or bisphosphonates alone. However, there are conflicting reports as to whether bisphosphonates adversely influence skeletal uptake of the bone-seeking radiotracers used for therapy. Recent studies analyzing influence of Zoledronic acid on total bone uptake of Samarium-153 EDTMP (Sm-153 EDTMP) by measuring cumulative urinary activity of Sm-153 on baseline study, as well as in combination with bisphosphonates (administrated 48 hours prior to Sm-153) did not provide any statistically significant difference in urinary excretion of Sm-153 between the two groups. It may be noted that the exact temporal sequence of bisphosphonate administration vis a vis radionuclide therapy has not yet been studied. One of the side effects of bisphosphonates is transient flare effect on bone pain. Radionuclide therapy may also have similar side effect. Keeping in view the above the current study was designed with the main objective of determining the exact timing of bisphosphonate administration in patients receiving combined therapy so as to achieve optimal efficacy of bone pain palliation. Ninety-three patients suffering from metastatic bone pain who received combination therapy with Sm-153 oxabifore (an analog of Sm-153 EDTMP) and Zoledronic acid were divided into three groups according to the timing of Zoledronic acid administration: Group I: 39 patients who received Zoledronic acid 7 or more days prior to Sm-153 oxabifore treatment; Group II: 32 patients who received Zoledronic acid 48-72 hours prior to Sm-153 oxabifore treatment and Group III: 22 patients who received Zoledronic acid 7 days after Sm-153 oxabifore treatment. Sm-153 oxabifore was administered

  7. Uso combinado de modelos de estresse no trabalho e a saúde auto-referida na enfermagem Uso combinado de modelos de estrés en el trabajo y la salud auto referida en la enfermería Combined use of job stress models and self-rated health in nursing

    Directory of Open Access Journals (Sweden)

    Rosane Härter Griep

    2011-02-01

    Full Text Available OBJETIVO: Identificar combinações de dois modelos do estresse psicossocial do trabalho em equipes de enfermagem e sua associação com a saúde auto-referida. MÉTODOS: Estudo transversal com trabalhadoras de três hospitais públicos do Município do Rio de Janeiro, RJ (N=1307. Foi aplicado questionário multidimensional que incluiu duas escalas de estresse no trabalho (modelo demanda-controle e desequilíbrio esforço-recompensa em 2006. Foram considerados o modelo demanda e controle parcial e completo (inclui apoio social no trabalho, assim como o esforço e recompensa parcial e completo (inclui excesso de comprometimento com o trabalho. Modelos de regressão múltipla foram utilizados para estimar razões de chances ajustadas e seus respectivos intervalos com 95% de confiança. RESULTADOS: As dimensões de ambos os modelos estiveram independentemente associadas à situação de saúde, com odds ratios entre 1,70 e 3,37. O modelo parcial demanda-controle mostrou-se menos associado à saúde (OR = 1,79; IC95% 1,26;2,53 quando comparado ao de desequilíbrio esforço-recompensa (OR=2,27; IC95% 1,57;3,30. A incorporação do apoio social e do excesso de comprometimento com o trabalho aumentou a força de associação dos modelos demanda-controle e desequilíbrio esforço-recompensa, respectivamente. Foi observado aumento na força de associação quando os dois modelos parciais foram combinados. CONCLUSÕES: Os resultados indicam melhor desempenho do modelo desequilíbrio esforço-recompensa para este grupo específico e para o desfecho avaliado e vantagem do uso de modelos completos ou do uso combinado em modelos parciais.OBJETIVO: Identificar combinaciones de dos modelos de estrés psicossocial del trabajo en equipos de enfermería y su asociación con la salud auto referida. MÉTODOS: Estudio transversal con trabajadoras de tres hospitales públicos del Municipio de Rio de Janeiro, Sureste de Brasil, (N=1307. Se aplicó cuestionario

  8. El Soporte Conductual Positivo y la comunicación como factores clave en la intervención educativa de los niños con TEA

    OpenAIRE

    Lizondo-Nieto, Elina Marcela

    2013-01-01

    En este trabajo, vamos a estudiar el Soporte Conductual Positivo aplicado a la Escuela (SCPE) como un método de intervención educativa que permite construir el aprendizaje de los niños con trastornos del espectro autista (TEA) a partir de las conductas problemáticas que estos manifiestan convirtiéndolas en habilidades, que, a su vez, van a ser reforzadas a través del sistema TEACCH, lo que combinado con un sistema alternativo y aumentativo de comunicación (SAAC), como el PECS, va ...

  9. Abordaje quirúrgico combinado como alternativa mínimamente invasiva en el tratamiento de la Gangrena de Fournier

    Directory of Open Access Journals (Sweden)

    Juan C. Larsson

    Full Text Available Introducción y Objetivo: La Gangrena de Fournier es una fascitis necrotizante del perineo y genitales externos que presenta una morbi-mortalidad elevada debido a su diagnóstico tardío y a las comorbilidades comúnmente asociadas en estos pacientes. Terapias adyuvantes como la presión negativa y los sustitutos dérmicos, han mostrado eficacia en el tratamiento de pacientes con defectos complejos de tejidos blandos y forman parte de nuestro protocolo de tratamiento actual. El objetivo de este estudio es describir la utilidad de nuestro abordaje quirúrgico combinado en la Gangrena de Fournier. Material y método. Presentamos un trabajo retrospectivo en el que describimos 3 pacientes varones tratados por defectos complejos de tejidos blandos secundarios a Gangrena de Fournier mediante nuestro protocolo de tratamiento quirúrgico que comprende: una primera etapa de control de la herida mediante desbridamientos agresivos y terapia de presión negativa, seguido de una etapa de contemporización que combina la utilización de matriz dérmica y terapia de presión negativa, y por último una etapa de reconstrucción para dar cobertura final al defecto. Resultados. Los 3 pacientes presentaron compromiso extenso de la región perineal y de las regiones adyacentes incluyendo genitales externos y miembros inferiores. Todos fueron tratados con éxito mediante el abordaje que describimos, sin secuelas funcionales y manteniendo el contorno a la región. Conclusiones. El abordaje utilizado en nuestros 3 casos representó una alternativa terapéutica eficaz. La combinación de terapia de presión negativa y matriz dérmica nos permitió un manejo simplificado de la herida y una reconstrucción con mayor seguridad y mínima morbilidad mediante cierre primario de las heridas y avance de colgajos locales.

  10. Distinguishing a SM-like MSSM Higgs boson from SM Higgs boson ...

    Indian Academy of Sciences (India)

    We explore the possibility of distinguishing the SM-like MSSM Higgs boson from the SM Higgs boson via Higgs boson pair production at future muon collider. We study the behavior of the production cross-section in SM and MSSM with Higgs boson mass for various MSSM parameters tan and A. We observe that at fixed ...

  11. New AMS method to measure the atom ratio {sup 146}Sm/{sup 147}Sm for a half-life determination of {sup 146}Sm

    Energy Technology Data Exchange (ETDEWEB)

    Kinoshita, N. [Tandem Accelerator Complex, Research Facility Center for Science and Technology, University of Tsukuba (Japan); Paul, M., E-mail: paul@vms.huji.ac.il [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel); Alcorta, M. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Bowers, M.; Collon, P. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556-5670 (United States); Deibel, C.M. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Joint Institute for Nuclear Astrophysics, Michigan State University, East Lansing, MI 46624 (United States); DiGiovine, B. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Goriely, S. [Universite Libre de Bruxelles, CP-226, Brussels 1050 (Belgium); Greene, J.P.; Henderson, D.J.; Jiang, C.L. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Kashiv, Y. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556-5670 (United States); Kay, B.P.; Lee, H.Y.; Marley, S.T. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Nakanishi, T. [Faculty of Chemistry, Institute of Science and Engineering, Kanazawa University (Japan); Pardo, R.C.; Patel, N.; Rehm, K.E. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Robertson, D. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556-5670 (United States); and others

    2013-01-15

    The extinct p-process nuclide {sup 146}Sm (t{sub 1/2} = 103 {+-} 5 Myr) is known to have been present in the Early-Solar System and has been proposed as an astrophysical chronometer. {sup 146}Sm is also intensely used to date meteorite and planetary differentiation processes, enhancing the importance of an accurate knowledge of the {sup 146}Sm half-life. We are engaged in a new determination of the {sup 146}Sm half-life in which the {sup 146}Sm/{sup 147}Sm atom ratio is determined by accelerator mass spectrometry at the ATLAS facility of Argonne National Laboratory. In order to reduce systematic errors in the AMS determination of the {sup 146}Sm/{sup 147}Sm ratios (in the range of 10{sup -7}-10{sup -9}), {sup 146}Sm and {sup 147}Sm ions were alternately counted in the same detector in the focal plane of a gas-filled magnet, respectively in continuous-wave and attenuated mode. Quantitative attenuation is obtained with the 12 MHz pulsed and ns-bunched ATLAS beam by chopping beam pulses with an RF sweeper in a ratio (digitally determined) down to 1:10{sup 6}. The experiments and preliminary results are discussed.

  12. Estabilidad de un producto dulce de tamarillo (Cyphomandra betacea conservado por métodos combinados

    Directory of Open Access Journals (Sweden)

    Xadeni Villegas-Ruíz

    2013-01-01

    Full Text Available El objetivo de este estudio fue aplicar la tecnología de métodos combinados para elaborar una base dulce (BDT de tamarillo (Cyphomandra betacea, así como evaluar su estabilidad durante el almacenamiento. La BDT fue preparada al pH natural de la fruta (3,72, con una actividad de agua (aw reducida (0,901 mediante la adición de sacarosa, y adicionada con benzoato de sodio (0,1% como antimicrobiano. La BDT se almacenó en refrigeración (4°C, protegida de la luz, y se evaluó cada tercer día durante 60 días determinando sus características fisicoquímicas (color, aw, pH y acidez titulable como ácido cítrico; antioxidantes (capacidad antioxidante, fenoles totales y antocianinas; y microbiológicas (bacterias mesófilas aerobias, mohos y levaduras. La BDT fue adicionada a yogurt natural para evaluar sensorialmente su aceptación general durante el almacenamiento; esta evaluación se llevó a cabo cada siete días durante 49 días. El tiempo de almacenamiento no tuvo efecto sobre la aw, el pH y la acidez de la BDT. Se observó un aumento en el cambio neto de color (de 0 a 4,9 y se registró disminución en los compuestos fenólicos totales (de 1,213 a 0,816 mg de ácido gálico/g BDT, en las antocianinas monoméricas totales (de 0,910 a 0,611 mg cianidina-3-glucósido/g de BDT y en la capacidad antioxidante (de 5,816 a 3,576 μmol Trolox/g BDT. Las cuentas de bacterias mesófilas aerobias, mohos y levaduras, aumentaron ligeramente durante el almacenamiento (de 0,05 durante el almacenamiento.

  13. Manifestaciones mucocutaneas en pacientes con lupus eritematoso sistemico

    Directory of Open Access Journals (Sweden)

    V. Saurit

    2003-08-01

    Full Text Available El objetivo fue estudiar en pacientes con lupus eritematoso sistémico (LES la prevalencia de las lesiones mucocutáneas. Se incluyeron 77 pacientes. Las lesiones mucocutáneas fueron clasificadas en específicas y no específicas. Se definió el fototipo, exposición solar y fotoprotección. Se relacionaron las lesiones con la serología y la actividad de la enfermedad. Las lesiones específicas encontradas fueron: agudas (67.5%, lupus subagudo (6.3% y lesiones crónicas (26.0%. Las lesiones no específicas fueron: alopecia difusa (59%, fotosensibilidad (57%, fenómeno de Raynaud (47%, úlceras orales (16% y livedo reticularis (12%. El fototipo 3 (35% fue predominante; la exposición a las radiaciones ultravioletas fue moderada en 74%. Sólo 47% utilizaron protectores solares. Los anticuerpos anti-Ro se relacionaron en forma significativa con eritema malar, fotosensibilidad, livedo reticularis y alopecia. Los anticuerpos anti-Sm se relacionaron con fenómeno de Raynaud. Todas estas lesiones se observaron con mayor frecuencia en pacientes con enfermedad activa. La prevalencia de las manifestaciones mucocutáneas fue ligeramente más elevada a la informada en otras series. Hubo mayor prevalencia de eritema malar, alopecia difusa, fotosensibilidad y livedo reticularis en pacientes con enfermedad activa y anti-Ro (+ y de fenómeno Raynaud con anti-Sm.(+.The objective was to analyze the prevalence of mucocutaneous lesions in patients with systemic lupus erythematosus (SLE. During a 3-year period, we analyzed 77 patients with a diagnosis of SLE. The mucocutaneous lesions were classified into specific and non-specific. We defined skin type, sunlight exposure and photoprotection and correlated these lesions with serology and disease activity. Acute specific lesions were found in 67.5% of the patients, subacute lupus in 6.5% and chronic lesions in 26.0%. The most prevalent non-specific lesions were alopecia (59.7%, photosensitivity (57.1%, Raynaud

  14. 24/7 SM slavery.

    Science.gov (United States)

    Dancer, Peter L; Kleinplatz, Peggy J; Moser, Charles

    2006-01-01

    This study describes the nature of 24/7 SM slavery as practiced within the SM (sadomasochistic) community. These SM participants, who attempt to live full-time in owner-slave roles, represent a small proportion of those with SM interests. SM slaves have not been studied systematically to determine if and how they differ from other SM practitioners. An online questionnaire was used to obtain responses from individuals who self-identified as slaves. A total of 146 respondents participated, 53% female and 47% male, ranging in age from 18 to 72. We explored the depth of their relationships, how well they approximated "slavery," and how their relationships were structured to maintain distinct roles. Data showed that in long-term SM slave relationships, a power differential exists which extends beyond time-limited SM or sexual interactions. Owners and slaves often use common, daily life experiences or situations, such as the completion of household chores, money management, and morning or evening routines, to distinguish and maintain their respective roles. In addition, contrary to the perception of total submission, results revealed that slaves exercise free will when it is in their best interests to do so. These relationships were long-lasting and satisfying to the respondents.

  15. Application of radioisotopes in the field of nuclear medicine

    International Nuclear Information System (INIS)

    Nayak, D.; Lahiri, S.

    1999-01-01

    A comprehensive review has been made to discuss the role of various radionuclides of lanthanide series elements in the field of nuclear medicine. The role of several pharmaceuticals labeled with radiolanthanides and used for investigative purposes like measurement of cerebral blood flow, bone density measurement, bone marrow imaging, etc., have been described. The role of lanthanide radionuclides in radiation synovectomy, radioimmunotherapy, etc., have also been discussed. Methods of preparation of some representative radiopharmaceuticals like 153 Sm-EDTMP, 153 Sm-HYP, have been presented. An outline on the production of carrier free radioisotopes of lanthanide series elements has been given. (author)

  16. Australian manufacture of QuadrametTM (Samarium-153 EDTMP)

    International Nuclear Information System (INIS)

    Wood, N.R.; Whitwell, J.

    1997-01-01

    Quadramet T (Samarium-153 EDTMP) has been shown overseas to be potentially useful in the palliation of painful osteoblastic skeletal metastases and has been approved this year for general marketing in the USA. Australian Radioisotopes (ARI) has licensed this product from the Australian patent holders, Dow Chemical. Within the facilities of ARI, a hot cell has been dedicated to this product and fitted out to manufacture it weekly on a cycle related to the operating cycle of the Australian reactor HIFAR. Due to neutron flux limitations of HIFAR, the local formulation has an elemental Samarium content up to 200μg/mL whereas the overseas formulation has a level of 20-46μg/mL. All other specifications of the two products are essentially the same. In 1995 and 1996 a small clinical trial with 19 patients was held which demonstrated that the pharmacokinetic behaviour was also essentially the same by measuring blood clearance rates and skeletal uptake dynamics. Soft tissue uptake was also qualitatively determined. The ARI version is now the subject of an application for general marketing within Australia. Some useful characteristics of this agent are: almost complete excretion or fixation in the skeleton within 6 hours, rapid onset of clinical effect, applicability in most cases where an abnormal diagnostic bone scan correlates with painful sites, dosage can be tailored to individual patient uptake due to easy dose measurement and retreatment is quite possible. The use of this class of agents in pain palliation continues to increase. Australian manufacture of Quadramet TM provides a further option in the management of these difficult cases

  17. Distinguishing a SM-like MSSM Higgs boson from SM Higgs boson at muon collider

    International Nuclear Information System (INIS)

    Singhal, Jai Kumar; Singh, Sardar; Nagawat, Ashok K.

    2007-01-01

    We explore the possibility of distinguishing the SM-like MSSM Higgs boson from the SM Higgs boson via Higgs boson pair production at future muon collider. We study the behavior of the production cross-section in SM and MSSM with Higgs boson mass for various MSSM parameters tanβ and m A . We observe that at fixed CM energy, in the SM, the total cross-section increases with the increase in Higgs boson mass whereas this trend is reversed for the MSSM. The changes that occur for the MSSM in comparison to the SM predictions are quantified in terms of the relative percentage deviation in cross-section. The observed deviations in cross-section for different choices of Higgs boson masses suggest that the measurements of the cross-section could possibly distinguish the SM-like MSSM Higgs boson from the SM Higgs boson. (author)

  18. Production planning in the Combinado Lácteo Santiago

    Directory of Open Access Journals (Sweden)

    Edith Carmen Fajardo-Alcolea

    2017-12-01

    Full Text Available A planning, programming and control of the production procedure is designed in this paper to consider all the technical and organizational aspects that are involved in planning, using the balance and normative method, and a variant of the General Algorithm for the Calculation of the Capacities. This procedure is supported by an innovative computer application designed to assist students, technicians and specialists in the planning stages. The procedure is applied in the company “Combinado Lácteo de Santiago de Cuba” to plan the production in 2016. As a result, an innovation of an organizational type is obtained that allows the Production Master Plan, disaggregated in the different time horizons, consider the real capacity of the plants. For its evaluation it was compared to the production plan prepared by the company and the actual production data of the first quarter of the year to determine the existing differences.

  19. Enfoque terapéutico en 154 pacientes con acromegalia

    Directory of Open Access Journals (Sweden)

    Marcos P. Manavela

    2010-08-01

    Full Text Available La acromegalia es una enfermedad poco frecuente producida en más del 95% de los casos por un tumor hipofisario secretor de hormona de crecimiento (GH. Las manifestaciones clínicas están asociadas a síntomas locales por crecimiento del tumor o a las consecuencias orgánicas y metabólicas secundarias a la hipersecreción de GH. Debido a la alta morbilidad y mortalidad asociadas a la acromegalia, un tratamiento individualizado y optimizado para cada paciente es fundamental. Informamos el enfoque terapéutico de nuestro servicio de endocrinología en la atención de 154 pacientes con acromegalia. Utilizando criterios bioquímicos estrictos, con la cirugía logramos un 32% de remisión global, tasa relativamente baja debido fundamentalmente a que la mayor parte de los pacientes presentaban macroadenomas con un alto porcentaje de invasividad local. Con radioterapia complementaria o como tratamiento inicial se logró la remisión en el 65.4% de los pacientes irradiados. El 14.0% de los pacientes controlaron la enfermedad utilizando agonistas dopaminérgicos solos o combinados con otra droga, mientras que aquellos que utilizaron análogos de la somatostatina normalizaron los parámetros bioquímicos en un 45.7% de los casos. En conclusión, con los diferentes tratamientos utilizados obtuvimos el control de la acromegalia en el 55.2% de los casos, esperando optimizar el tratamiento de estos pacientes en la medida en que contemos con y tengamos acceso a nuevas herramientas terapéuticas.

  20. Calorimetric investigation on the Pb-Sm and Sn-Sm alloys

    International Nuclear Information System (INIS)

    Berrada, A.-E.-A.; Claire, Y.; Chafik el Idrissi, M.; Castanet, R.

    1997-01-01

    The integral enthalpy of formation of the Sm-Pb and Sm-Sn melts at 1203 K, h f , was determined by direct reaction calorimetry (drop method) in the Pb and Sn rich sides with the help of a high-temperature Tian-Calvet calorimeter. The results can be fitted respectively with reference to the mole fraction of samarium, x, as follows: f /kJmol -1 =x(1-x)(-109.8 -372.0.7x) with 0 Sm f /kJmol -1 =x(1- x)(-277.0+105.4x) with 0 Sm -1 respectively. Such negative values suggest the existence of a strong short-range order in the liquid state. The stoichiometry and the thermal stability of these associations needs additional thermodynamic determinations concerning mainly the free enthalpy of formation. It will be determined by Knudsen-effusion combined with mass spetrometry in a further work. (orig.)

  1. Evaluation of the exothermicity of the chemi-ionization reaction Sm + O → SmO+ + e−

    International Nuclear Information System (INIS)

    Cox, Richard M; Kim, JungSoo; Armentrout, P. B.; Bartlett, Joshua; VanGundy, Robert A.; Heaven, Michael C.; Ard, Shaun G.; Shuman, Nicholas S.; Viggiano, Albert A.; Melko, Joshua J.

    2015-01-01

    The exothermicity of the chemi-ionization reaction Sm + O → SmO + + e − has been re-evaluated through the combination of several experimental methods. The thermal reactivity (300–650 K) of Sm + and SmO + with a range of species measured using a selected ion flow tube-mass spectrometer apparatus is reported and provides limits for the bond strength of SmO + , 5.661 eV ≤ D 0 (Sm + -O) ≤ 6.500 eV. A more precise value is measured to be 5.72 5 ± 0.07 eV, bracketed by the observed reactivity of Sm + and SmO + with several species using a guided ion beam tandem mass spectrometer (GIBMS). Combined with the established Sm ionization energy (IE), this value indicates an exothermicity of the title reaction of 0.08 ± 0.07 eV, ∼0.2 eV smaller than previous determinations. In addition, the ionization energy of SmO has been measured by resonantly enhanced two-photon ionization and pulsed-field ionization zero kinetic energy photoelectron spectroscopy to be 5.7427 ± 0.0006 eV, significantly higher than the literature value. Combined with literature bond energies of SmO, this value indicates an exothermicity of the title reaction of 0.14 ± 0.17 eV, independent from and in agreement with the GIBMS result presented here. The evaluated thermochemistry also suggests that D 0 (SmO) = 5.83 ± 0.07 eV, consistent with but more precise than the literature values. Implications of these results for interpretation of chemical release experiments in the thermosphere are discussed

  2. Paladar Hendido, Tratamiento quirúrgico, Injerto óseo combinado con plasma rico en plaquetas

    OpenAIRE

    Monserat Soto, Enrique R.; Ramos, Alexis; Tovar Mattar, Ricardo

    2006-01-01

    Hace unos años en las décadas 40 y 50 del siglo pasado se realizaron estudios, debido a que se observó hipodesarrollo del tercio medio de la cara como consecuencia del tratamiento quirúrgico en épocas tempranas de la vida del paciente con paladar fisurado. Cirujanos odontólogos comenzaron a utilizar el injerto óseo para conseguir la integridad anatómica del arco alveolar y así facilitar su desarrollo, la erupción dentaria y las funciones intermaxilares. Estas intervenciones son muy cruentas p...

  3. Strategisch management (SM)

    NARCIS (Netherlands)

    Nagel, A.P.; Vercouteren, W.J.J.C.; Hoek, van der N.; Lohman, T.A.M.; Vermeulen, N.

    1996-01-01

    Kernbegrippen die bij de discussie van strategisch management (SM) aan de orde komen, zijn productinnovatie op ondernemingsniveau (oftewel strategische productinnovatie, SPI) en technologiestrategie. In dit artikel wordt een raamwerk van SM geintroduceerd. Daartoe worden de verschillende fasen van

  4. Detection of antifungal properties in Lactobacillus paracasei subsp. paracasei SM20, SM29, and SM63 and molecular typing of the strains.

    Science.gov (United States)

    Schwenninger, Susanne Miescher; von Ah, Ueli; Niederer, Brigitte; Teuber, Michael; Meile, Leo

    2005-01-01

    Lactobacilli isolated from different food and feed samples such as raw milk, cheese, yoghurt, olives, sour dough, as well as corn and grass silage, were screened for their antifungal activities. Out of 1,424 isolates tested, 82 were shown to be inhibitory to different yeasts (Candida spp. and Zygosaccharomyces bailii) and a Penicillium sp., which were previously isolated from spoiled yoghurt and fruits. Carbohydrate fermentation patterns suggested that a substantial portion, 25%, belonged to the Lactobacillus casei group, including L. casei, L. paracasei, and L. rhamnosus. The isolates SM20 (DSM14514), SM29 (DSM14515), and SM63 (DSM14516) were classified by PCR using species-specific primers to target the corresponding type strains (L. casei, L. paracasei, and L. rhamnosus) as controls. Further molecular typing methods such as randomly amplified polymorphic DNA, pulsed-field gel electrophoresis, and sequencing analysis of the 16S rRNA gene allowed classifying strains SM20, SM29, and SM63 as L. paracasei subsp. paracasei in accordance with the new reclassification of the L. casei group proposed by Collins et al.

  5. Coercivity Recovery Effect of Sm-Fe-Cu-Al Alloy on Sm2Fe17N3 Magnet

    Science.gov (United States)

    Otogawa, Kohei; Asahi, Toru; Jinno, Miho; Yamaguchi, Wataru; Takagi, Kenta; Kwon, Hansang

    2018-03-01

    The potential of a Sm-Fe-Cu-Al binder for improvement of the magnetic properties of Sm2Fe17N3 was examined. Transmission electron microscope (TEM) observation of a Sm-Fe-Cu-Al alloy-bonded Sm2Fe17N3 magnet which showed high coercivity revealed that the Sm-Fe-Cu-Al alloy had an effect of removing the surface oxide layer of the Sm2 Fe17N3 grains. However, the Sm-Fe-Cu-Al binder was contaminated by carbon and nitrogen, which originated from the organic solvent used as the milling medium during pulverization. To prevent carbon and nitrogen contamination, the Sm-Fe- Cu-Al alloy was added directly on the surface of the Sm2Fe17N3 grains by sputtering. Comparing the recovered coercivity per unit amount of the added binder the uncontaminated binder-coated sample had a higher coercivity recovery effect than the milled binder-added sample. These results suggested that sufficient addition of the contamination-free Sm-Fe-Cu-Al binder has the possibility to reduce the amount of binder necessary to produce a high coercive Sm2Fe17N3 magnet.

  6. In vivo radiochemical properties of Tb-149: A new radiolanthanide for targeted cancer therapy

    International Nuclear Information System (INIS)

    Allen, B.J.; Beyer, G.J.; Morel, C.H.; Aleksandrova, Y.; Jahn, S.

    1996-01-01

    Full text: 149 Tb (4.15 h) decays by the emission of both 3.9 MeV alpha particles (17% branching) and positrons (4% branch), and uniquely combines both therapeutic and PET diagnostic properties. In this paper we report the production route, systemic studies of radio-lanthanides with ethylenediaminetetra methylene phosphonate (EDTMP) ligand, and the first 149 Tb phantom studies using PET. The radio-lanthanides used in this study were produced at the ISOLDE (isotope separator on-line) facility at CERN. They are produced carrier free, isotopically and chemically separated (isobaric separation using cation exchange chromatography) in a form suitable for protein labelling. Batches up to 20 mCi of 1 4 9T b are available. We have established relationships between biokinetics, EDTMP concentration, and the ionic radius of the radiolanthanide used. The tumour to liver ratio in mice reaches a maximum value at 1 mM 10 mM and decreases from 10 by almost two decades according to the ionic radius of the lanthanide. For Tb, a tumour to liver ratio of 5 can be obtained, similar to Gd. No significant differences in the uptake in bone for all lanthanides in the EDTMP system were observed. A fast blood clearance allows clear bone images to be obtained via PET at 60-90 min post-injection, as shown with rabbits using 142 Sm-EDTMP. The first phantom PET studies with 149 Tb are also reported. We conclude that the fast biokinetics and the alpha decay mode open up new possibilities for a more efficient endo-radionuclide therapy using EDTMP. The high purity of the 149T b (isotopically separated and carrier free) produced in this way makes it very suitable for the labelling of octretides

  7. Combinación de pronósticos y variables predictoras con error

    Directory of Open Access Journals (Sweden)

    Elkin Castaño V

    1994-07-01

    Full Text Available Éste documento discute algunos métodos para obtener pronósticos mejorados a partir de la combinación de las predicciones generadas por diferentes modelos. Además presenta un estudio de simulación para comparar en el corto, mediano y largo plazo, el comportamiento del pronostico combinado de un modelo econométrico y de un modelo arima con los pronósticos individuales de cada modelo, cuando los valores futuros de las predictoras del modelo econométrico contienen errores, el procedimiento de la mezcla de pronósticos generó predicciones más precisas en el corto, mediano y largo plazo.

  8. ELABORACIÓN E IMPLEMENTACIÓN DE UN SEMINARIO DE DIDÁCTICA DE LA BIOLOGÍA Y SU INTEGRACIÓN CON LAS TIC.

    Directory of Open Access Journals (Sweden)

    Maria Charrier Melillán

    2014-05-01

    Full Text Available La incorporación de las TIC a la educación abrió grandes posibilidades para mejorar los procesos de enseñanza y aprendizaje. No obstante, no alcanza con dotar a las escuelas de computadoras, hace falta un cambio en la organización de la misma y en las competencias digitales de los profesores. El presente seminario tuvo como objetivo que los profesores comprendan que el uso de los recursos didácticos combinados con las TIC promueven un cambio tanto conceptual como metodológico de la enseñanza de las ciencias el que deberá plasmarse en una actividad concreta de enseñanza.

  9. Entrenamiento cognitivo en memoria de trabajo para niños con TDAH: ensayo clínico aleatorizado

    OpenAIRE

    Bigorra Gualba, Aitana

    2017-01-01

    Objetivos: En el TDAH existen déficits en las Funciones Ejecutivas (FFEE) y en especial en la Memoria de trabajo (MT), que repercuten negativamente en el rendimiento académico, los síntomas clínicos, y la adaptación funcional. Los objetivos de este estudio fueron analizar la eficacia de un entrenamiento computarizado en MT sobre otras FFEE frías y calientes, aprendizajes, síntomas clínicos y adaptación funcional. Método: Se incluyeron 66 niños con TDAH tipo combinado entre 7 y 12 años de edad...

  10. Déficit en Habilidades Sociales en Niños con Trastorno por Déficit de Atención-Hiperactividad, Evaluados con la Escala basc/ Social Skills Deficits in Children Diagnosed With Attention Deficit Hyperactivity Disorder Evaluated With the BASC Escale/ Déficit em Habilidades Sociais em Crianças com Transtorno por Déficit de Atenção-Hiperatividade, Avaliados com a Escala BASC

    Directory of Open Access Journals (Sweden)

    Pedro Puentes Rozo

    2014-07-01

    Full Text Available Se analizaron las Habilidades Sociales (HS de 159 niños de ambos sexos, escolarizados, con Trastorno por Déficit de Atención-Hiperactividad (TDAH, entre los 6 y los 11 años de edad. La valoración de las HS se realizó con la escala Behavioral Assessment System for Children para padres y maestros. Los resultados mostraron que los niños con TDAH presentan puntajes más bajos en las dimensiones de habilidades sociales como escuchar, esperar turnos, reconocer señales sociales y tener capacidad de adaptabilidad. Sin embargo, en compañerismo, los participantes con TDAH combinado poseen habilidades semejantes a los no afectados. Esto replantea lo encontrado en la mayoría de los estudios en donde únicamente se evidencian deficiencias.

  11. Temperature dependence of spin and orbital magnetic moments of Sm 4f electrons in (Sm, Gd)Al2

    International Nuclear Information System (INIS)

    Qiao, S.; Kimura, A.; Adachi, H.; Iori, K.; Miyamoto, K.; Xie, T.; Namatame, H.; Taniguchi, M.; Tanaka, A.; Muro, T.; Imada, S.; Suga, S.

    2005-01-01

    X-ray magnetic circular dichroism studies were carried out on (Sm, Gd)Al 2 , a ferromagnet without net magnetization at a certain compensation temperature. For Sm 4f electrons, the following understandings were obtained: the magnitude of expectation value of orbital magnetic moment (m L Sm ) is always larger than that of spin one (m S Sm ), so the cancellation of total spin and orbital magnetic moments cannot be achieved only by Sm 4f electrons and the contributions from Gd ions and conduction electrons are important; when the temperature decreases, the magnitude of both m L Sm and m S Sm increases and the gross magnetic moment due to the Sm 4f electrons monotonically deviates from zero. These results tell us that the temperature dependence of magnetic moments related with the electrons other than Sm 4f ones may play important roles in the subtle adjustment of the total spin and orbital magnetic moments to the zero magnetization at the compensation temperature

  12. Tratamiento conservador en pacientes con retinoblastoma bilateral

    Directory of Open Access Journals (Sweden)

    Juan C. Suárez

    2008-11-01

    Full Text Available OBJETIVO: comparar el tratamiento convencional del retinoblastoma bilateral, usado hasta hace algunos años, consistente en radioterapia o enucleación bilateral, con el tratamiento conservador actual que incluye termoterapia transpupilar (TTT o TTT/quimioterapia al menos en un ojo, en niños con diagnóstico de retinoblastoma bilateral. DISEÑO: estudio retrospectivo descriptivo. MUESTRA: 20 pacientes con diagnóstico de retinoblastoma bilateral que consultaron al Hospital Universitario San Vicente de Paúl, de Medellín, Colombia, entre 1997 y 2007. MÉTODO: se hizo enucleación del ojo con el tumor de mayor tamaño. En el otro ojo se hizo tratamiento con TTT, con el láser diodo (810 nm, spot amplio, solo o combinado con otras terapias. RESULTADOS: se dividió a los pacientes en dos grupos: 16 pacientes (32 ojos en el grupo 1 tratados conservadoramente y 4 pacientes (8 ojos en el grupo 2 con tratamiento convencional. El rango de edad fue de 1-72 meses en el grupo 1 y de 1-12 meses en el grupo 2. El tiempo de seguimiento fue de 7-67 meses para el grupo 1 y de 13-73 meses para el grupo 2. En el grupo 1 se hizo enucleación de 16 ojos (50%, radioterapia externa de uno (3,1%, quimioterapia más termoterapia de 5 (15,6% y quimioterapia más termoterapia más crioterapia de 10 (31,3%. En todos los pacientes se logró preservar al menos un ojo. En el grupo 2, se enuclearon 7 ojos (87,5% y se hizo radioterapia externa más enucleación en un paciente (12.5%. Además, todos los pacientes recibieron quimioterapia. CONCLUSIÓN: la terapia conservadora actual consistente en tratamiento local (termoterapia, crioterapia o braquiterapia y quimiorreducción permite preservar al menos un ojo y en algunos casos de los dos, muchas veces con buena agudeza visual, en niños con retinoblastoma bilateral; se evitan así la enucleación bilateral y la radioterapia externa usada en el tratamiento convencional con todos sus efectos secundarios. La enucleación contin

  13. Dielectric spectroscopy of the SmQ* phase

    Science.gov (United States)

    Perkowski, P.; Bubnov, A.; Piecek, W.; Ogrodnik, K.; Hamplová, V.; Kašpar, M.

    2011-11-01

    Liquid crystal possessing two biphenyl moieties in the molecular core and lateral chlorine substitution far from the chiral chain has been studied by dielectric spectroscopy. On cooling from the isotropic phase, the material possesses the frustrated smectic Q* (SmQ*) and SmCA* phases. It has been confirmed by dielectric spectroscopy that the SmQ* phase can be related to the SmCA* anti-ferroelectric phase. However, only one relaxation process has been observed in the SmQ* phase, while in the SmCA*, two relaxations are clearly detectable. It seems that the mode found in the SmQ* can be connected with high-frequency anti-phase mode observed in the SmCA* phase. Its relaxation frequency is similar to PH relaxation frequency, but is weaker. The same relaxation has been observed even a few degrees above the SmQ*-Iso phase transition. Another explanation for the mode detected in SmQ* and isotropic phases can be molecular motions around short molecular axis.

  14. PRESENCIA DE SÍNDROME METABÓLICO EN PACIENTES CON VIH EN EL HOSPITAL DE SEGURIDAD SOCIAL DE IQUITOS, 2011

    Directory of Open Access Journals (Sweden)

    Ricardo Chávez Chacaltana

    2012-06-01

    Full Text Available Se ha descrito la presencia del síndrome metabólico (SM en pacientes con VIH que reciben terapia antiretroviral (TAR. La presencia del SM implica un mayor riesgo cardiovascular y la eventual modificación de la terapia antiretroviral. El objetivo del presente estudio fue determinar la prevalencia y las características del SM en pacientes con VIH que reciben TAR. La metodología fue descriptiva y transversal. Se evaluó a 78 pacientes entre junio a Setiembre del 2011. La evaluación fue clínica y de laboratorio (glicemia, colesterol, HDL y triglicéridos. Se encontró hipertrigliridemia (42.3%, colesterol HDL bajo (30.8%, hipertensión arterial (19.2%, obesidad abdominal (17.9%, e hiperglicemia en ayunas (12.8%. La prevalencia del síndrome metabólico fue de 19.2% (IC95% 17.4-21.0%; predomino en las mujeres (25.0% que en los hombres (17.7%, una mayor tendencia en mayores de 40 a más a años, con 6 a más años de TAR, y con esquema INTR + Lopinavir/ritonavir (28.0%, INTR+ Efavirenz (19.2% y INTR + Atazanavir (11.1%. El síndrome metabólico es prevalente en los pacientes con VIH, se recomienda considerar prioritario un oportuno un manejo integral e individualizado.

  15. Optical isotype shifts of 146Sm and 151Sm

    International Nuclear Information System (INIS)

    Eastham, D.A.; Walker, P.M.; Griffith, J.A.R.; Evans, D.E.; England, J.G.; Grant, I.S.

    1984-01-01

    We have measured the optical isotope shifts of 146 Sm and 151 Sm by laser resonance fluorescence. From these measurements the changes in the mean square nuclear radii are: delta 2 > (A=144 to 146)=0.266(10) fm 2 , and delta 2 > (A=151 to 152)=0.262(10) fm 2 . These results, together with those of the stable isotopes, show that the average nuclear expansion of samarium can be accounted for by the liquid drop model with deformations. (orig.)

  16. SM18 Visits and Access

    CERN Multimedia

    2012-01-01

      VISITS The rules and conditions to be followed for visits in the SM18 Hall are laid out in the EDMS 1205328 document. No visit is allowed without prior reservation.   ACCESS Special access right is needed ONLY from 7 p.m. to 7 a.m. and during week-ends. From 1 December, the current SM18 access database will be closed and a new one “SM18-OWH outside normal hours” started from scratch. Requests, via EDH SM18-OWH, will have to be duly justified.   For further information, please contact Evelyne Delucinge.

  17. HDDR in Sm-Co alloys - a new method for magnetic hardening of Sm-Co permanent magnets

    Energy Technology Data Exchange (ETDEWEB)

    Kubis, M.; Handstein, A.; Gebel, B.; Mueller, K.-H.; Schultz, L. [Institut fuer Festkoerper- und Werkstofforschung Dresden e.V. (Germany). Inst. fuer Metallische Werkstoffe; Gutfleisch, O. [Institut fuer Festkoerper- und Werkstofforschung Dresden e.V. (Germany). Inst. fuer Metallische Werkstoffe]|[Birmingham Univ. (United Kingdom). School of Metallurgy and Materials

    1998-07-01

    Investigations on the hydrogen absorption behavior of different Sm-Co alloys with 1:5 and 2:17 structure by differential scanning calorimetry (DSC) at enhanced hydrogen pressures between 1 MPa and 7 MPa indicated different hydrogen absorption events. X-ray diffraction (XRD) studies and microstructural investigations showed clearly the disproportionation of the Sm-Co phases into Sm hydride and Co or Co-rich phases for hydrogen pressures above 0.5 MPa. The favourable effect of high hydrogen pressures can be explained in terms of a decrease of the free enthalpy of the samarium hydride for increasing hydrogen pressures. Additionally, Sm-Co alloys of both types were reactively milled under hydrogen at enhanced temperatures. The reactively milled powders showed again the products of the disproportionation reaction. A recombination of Sm-Co phases by removing the hydrogen in a second heat treatment was successful for both methods. Investigations of the magnetic properties showed coercivities {mu}{sub OJ}H{sub C} of up to 2.1 T for high pressure HDDR powders of SmCo{sub 5} material, demonstrating clearly the positive effect of the hydrogen treatment on the coercivity. The reactively milled powders showed for recombination temperatures {<=}700 C a remanence enhancement which could be attributed to the exchange coupling of the nanoscaled grains. A maximum coercivity {mu}{sub OJ}H{sub C} of 3.7 T was achieved for SmCo{sub 5} and a maximum energy product (BH){sub max} of 82 kJ/m{sup 3} was measured for an Sm-rich Sm{sub 2}Co{sub 17} sample. (orig.)

  18. HDDR in Sm-Co alloys - a new method for magnetic hardening of Sm-Co permanent magnets

    International Nuclear Information System (INIS)

    Kubis, M.; Handstein, A.; Gebel, B.; Mueller, K.-H.; Schultz, L.; Gutfleisch, O.; Birmingham Univ.

    1998-01-01

    Investigations on the hydrogen absorption behavior of different Sm-Co alloys with 1:5 and 2:17 structure by differential scanning calorimetry (DSC) at enhanced hydrogen pressures between 1 MPa and 7 MPa indicated different hydrogen absorption events. X-ray diffraction (XRD) studies and microstructural investigations showed clearly the disproportionation of the Sm-Co phases into Sm hydride and Co or Co-rich phases for hydrogen pressures above 0.5 MPa. The favourable effect of high hydrogen pressures can be explained in terms of a decrease of the free enthalpy of the samarium hydride for increasing hydrogen pressures. Additionally, Sm-Co alloys of both types were reactively milled under hydrogen at enhanced temperatures. The reactively milled powders showed again the products of the disproportionation reaction. A recombination of Sm-Co phases by removing the hydrogen in a second heat treatment was successful for both methods. Investigations of the magnetic properties showed coercivities μ OJ H C of up to 2.1 T for high pressure HDDR powders of SmCo 5 material, demonstrating clearly the positive effect of the hydrogen treatment on the coercivity. The reactively milled powders showed for recombination temperatures ≤700 C a remanence enhancement which could be attributed to the exchange coupling of the nanoscaled grains. A maximum coercivity μ OJ H C of 3.7 T was achieved for SmCo 5 and a maximum energy product (BH) max of 82 kJ/m 3 was measured for an Sm-rich Sm 2 Co 17 sample. (orig.)

  19. Láser helio-neón combinado con clorhexidina al 0,2 %.: Efectos clínicos y microbiológicos en el tratamiento de la gingivitis crónica Helium-neon laser combined with 0.2% chlorhexidine: Clinical and microbiological effects in the treatment of chronic gingivitis.

    Directory of Open Access Journals (Sweden)

    Tatiana Peña Ruiz

    2007-09-01

    Full Text Available La gingivitis crónica constituye una de las formas más frecuentes de enfermedad periodontal, caracterizada por la inflamación crónica de la encías, tumefacción, enrojecimiento y sangramiento. Su principal factor de riesgo lo constituye la microbiota del surco gingival, que resulta necesario, pero no suficiente para desencadenarla. Se realizó un ensayo clínico-terapéutico fase II, controlado, aleatorizado y a simple ciegas, para evaluar los efectos clínicos y microbiológicos del tratamiento combinado de la radiación láser helio-neón (He-Ne con la clorhexidina al 0,2 %. Todos los pacientes recibieron tratamiento inicial; al mes de finalizado este, se distribuyeron aleatoriamente en 2 grupos: un grupo estudio que recibió la combinación láser-neón y clorhexidina al 0,2 % y otro grupo control que solo recibió clorhexidina al 0,2 %. Se realizó una evaluación a los 15, 30 y 45 días, con criterios de eficacia clínicos y microbiológicos. Los resultados clínicos fueron satisfactorios en el grupo estudio con predominio de los morfotipos I, caracterizados por cocos gramnegativos y positivos, compatibles con un periodonto sano. Los eventos adversos detectados con esta terapéutica fueron mínimos, todos relacionados con la somnolencia.Chronic gingivitis is one of the most common periodontal diseases that is characterized by chronic inflammation, tumefaction, redness and bleeding. The main risk factor is gingival sulcus microbiota that is essential but not enough to unleash it. A phase II controlled randomized blind clinical/therapeutical assay was conducted to evaluate the clinical and microbiological effects of the combined treatment based on helium-neon laser (He-Ne with 0.2% chlorhexidine. All the patients were initially treated; after a month, they were randomly distributed into two groups, that is, the study group received a helium-neon laser plus 0.2% chlorhexidine combination and the control group was treated with 0

  20. The Protein Kinase SmSnRK2.6 Positively Regulates Phenolic Acid Biosynthesis in Salvia miltiorrhiza by Interacting with SmAREB1.

    Science.gov (United States)

    Jia, Yanyan; Bai, Zhenqing; Pei, Tianlin; Ding, Kai; Liang, Zongsuo; Gong, Yuehua

    2017-01-01

    Subclass III members of the sucrose non-fermenting-1-related protein kinase 2 (SnRK2) play essential roles in both the abscisic acid signaling and abiotic stress responses of plants by phosphorylating the downstream ABA-responsive element (ABRE)-binding proteins (AREB/ABFs). This comprehensive study investigated the function of new candidate genes, namely SmSnRK2.3 , SmSnRK2.6 , and SmAREB1 , with a view to breeding novel varieties of Salvia miltiorrhiza with improved stress tolerance stresses and more content of bioactive ingredients. Exogenous ABA strongly induced the expression of these genes. PlantCARE predicted several hormones and stress response cis -elements in their promoters. SmSnRK2.6 and SmAREB1 showed the highest expression levels in the leaves of S. miltiorrhiza seedlings, while SmSnRK2.3 exhibited a steady expression in their roots, stems, and leaves. A subcellular localization assay revealed that both SmSnRK2.3 and SmSnRK2.6 were located in the cell membrane, cytoplasm, and nucleus, whereas SmAREB1 was exclusive to the nucleus. Overexpressing SmSnRK2.3 did not significantly promote the accumulation of rosmarinic acid (RA) and salvianolic acid B (Sal B) in the transgenic S. miltiorrhiza hairy roots. However, overexpressing SmSnRK2.6 and SmAREB1 increased the contents of RA and Sal B, and regulated the expression levels of structural genes participating in the phenolic acid-branched and side-branched pathways, including SmPAL1 , SmC4H , Sm4CL1 , SmTAT , SmHPPR , SmRAS , SmCHS , SmCCR , SmCOMT , and SmHPPD . Furthermore, SmSnRK2.3 and SmSnRK2.6 interacted physically with SmAREB1. In summary, our results indicate that SmSnRK2.6 is involved in stress responses and can regulate structural gene transcripts to promote greater metabolic flux to the phenolic acid-branched pathway, via its interaction with SmAREB1 , a transcription factor. In this way, SmSnRK2.6 contributes to the positive regulation of phenolic acids in S. miltiorrhiza hairy roots.

  1. The Protein Kinase SmSnRK2.6 Positively Regulates Phenolic Acid Biosynthesis in Salvia miltiorrhiza by Interacting with SmAREB1

    Directory of Open Access Journals (Sweden)

    Yanyan Jia

    2017-08-01

    Full Text Available Subclass III members of the sucrose non-fermenting-1-related protein kinase 2 (SnRK2 play essential roles in both the abscisic acid signaling and abiotic stress responses of plants by phosphorylating the downstream ABA-responsive element (ABRE-binding proteins (AREB/ABFs. This comprehensive study investigated the function of new candidate genes, namely SmSnRK2.3, SmSnRK2.6, and SmAREB1, with a view to breeding novel varieties of Salvia miltiorrhiza with improved stress tolerance stresses and more content of bioactive ingredients. Exogenous ABA strongly induced the expression of these genes. PlantCARE predicted several hormones and stress response cis-elements in their promoters. SmSnRK2.6 and SmAREB1 showed the highest expression levels in the leaves of S. miltiorrhiza seedlings, while SmSnRK2.3 exhibited a steady expression in their roots, stems, and leaves. A subcellular localization assay revealed that both SmSnRK2.3 and SmSnRK2.6 were located in the cell membrane, cytoplasm, and nucleus, whereas SmAREB1 was exclusive to the nucleus. Overexpressing SmSnRK2.3 did not significantly promote the accumulation of rosmarinic acid (RA and salvianolic acid B (Sal B in the transgenic S. miltiorrhiza hairy roots. However, overexpressing SmSnRK2.6 and SmAREB1 increased the contents of RA and Sal B, and regulated the expression levels of structural genes participating in the phenolic acid-branched and side-branched pathways, including SmPAL1, SmC4H, Sm4CL1, SmTAT, SmHPPR, SmRAS, SmCHS, SmCCR, SmCOMT, and SmHPPD. Furthermore, SmSnRK2.3 and SmSnRK2.6 interacted physically with SmAREB1. In summary, our results indicate that SmSnRK2.6 is involved in stress responses and can regulate structural gene transcripts to promote greater metabolic flux to the phenolic acid-branched pathway, via its interaction with SmAREB1, a transcription factor. In this way, SmSnRK2.6 contributes to the positive regulation of phenolic acids in S. miltiorrhiza hairy roots.

  2. PRESENCIA DE SÍNDROME METABÓLICO EN PACIENTES CON VIH EN EL HOSPITAL DE SEGURIDAD SOCIAL DE IQUITOS, 2011

    Directory of Open Access Journals (Sweden)

    Ricardo Chávez Chacaltana

    2012-06-01

    Full Text Available Se ha descrito la presencia del síndrome metabólico (SM en pacientes con VIH que reciben terapia antiretroviral (TAR. La presencia del SM implica un mayor riesgo cardiovascular y la eventual modificación de la terapia antiretroviral. El objetivo del presente estudio fue determinar la prevalencia y las características del SM en pacientes con VIH que reciben TAR. La metodología fue descriptiva y transversal. Se evaluó a 78 pacientes entre Junio a Setiembre del 2011. La evaluación fue clínica y de laboratorio (glicemia, colesterol, HDL y triglicéridos. Se encontró hipertrigliridemia (42.3%, colesterol HDL bajo (30.8%, hipertensión arterial (19.2%, obesidad abdominal (17.9%, e hiperglicemia en ayunas (12.8%. La prevalencia del síndrome metabólico fue de 19.2% (IC95% 17.4-21.0%; predomino en la mujeres (25.0% que en los hombres (17.7%, una mayor tendencia en  mayores de 40 a más a años, con 6 a más años de TAR, y con esquema INTR + Lopinavir/ritonavir (28.0%, INTR+ Efavirenz (19.2% y INTR + Atazanavir (11.1%. El síndrome metabólico es prevalente en los pacientes con VIH, se recomienda considerar prioritario un oportuno un manejo integral e individualizado.

  3. SM-1420 computer conjugation with the ES-5017 magnetic tape storage device and the SM-6313 printer

    International Nuclear Information System (INIS)

    Zhurkin, V.V.; Safonov, A.A.; Troitskij, A.N.

    1987-01-01

    The flow sheets are given and the methods of the technical implementation of expansion units of SM 5002.4 controllers to connect NML ES-5017 and analogue-digital printer ATsPU SM-6818, respectively, to SM-1420 computer are described

  4. Småhuse: Indretning og funktion

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place; Sigbrand, Lone; Frandsen, Anne Kathrine

    Denne anvisning omhandler generelle krav og anbefalinger til indretning og funktion af nybyggede småhuse i henhold til bestemmelserne i Bygningsreglement 2010 (BR10). Småhuse - Indretning og funktionSmåhuse omfatter fritliggende og sammenbyggede enfamiliehuse med lodret lejlighedsskel i indtil...

  5. Excited states in 146Sm and 147Sm

    International Nuclear Information System (INIS)

    Kownacki, J.; Sujkowski, Z.; Hammaren, E.; Liukkonen, E.; Piiparinen, M.; Lindblad, Th.; Ryde, H.

    1979-10-01

    The sup(144,146)Nd(α,xn) and sup(146,148)Nd( 3 He,xn) reactions with Esub(α) = 20 - 43 MeV and E 3 sub(He) = 19 - 27 MeV are used to investigate excited states in the isotopes 146 Sm and 147 Sm. The experiments involve measurements of singles γ-ray spectra and conversion electron spectra, γ-ray angular distributions and three parameter (E sub(γ)E sub(γ) time) coincidences. From these experiments information is obtained for states with spin up to I = 13 + and I = 27/2 - , respectively, These states are interpeted within the framework of the cluster-vibration model (CVM) as well as the shell model. (author)

  6. Relación de cortisol sérico con los componentes del síndrome metabólico, ingesta alimentaria y trastorno de ansiedad en niños de 8 a 12 años con obesidad Relationship of serum cortisol and metabolic syndrome components, dietary intakes and anxiety disorder in children at 8 to 12 years of age with obesity

    OpenAIRE

    D.C. Treviño Villarreal; V. López Guevara; L.E. Ramírez López; A. Tijerina Sáenz

    2012-01-01

    Introducción: La obesidad es un trastorno que se asocia con ingesta alimentaria inadecuada y problemas psicológicos y predispone a complicaciones entre ellas el Síndrome Metabólico (SM), el cual ha sido relacionado con el estrés crónico debido a alteraciones en la actividad del eje Hipotálamo-Hipófisis-Adrenal (HHA) mediado por el hipercortisolismo. Objetivo: Determinar la relación del cortisol sérico con los componentes del SM, ingesta alimentaria y trastorno de ansiedad en niños de 8 a 12 a...

  7. Estratificación de riesgo en la insuficiencia aórtica grave asintomática: ¿cómo podemos identificar a los pacientes con evolución adversa?

    Directory of Open Access Journals (Sweden)

    Juan Krauss

    2007-01-01

    Full Text Available AntecedentesNo está determinado cómo se evalúa el riesgo en la insuficiencia aórtica (IA grave asintomática, dado que no hay consenso acerca de qué variables deben considerarse para predecir una evolución más adversa.ObjetivoEvaluar un score que incorpore variables clínicas y ecocardiográficas para identificar a pacientes con IA grave susceptibles de peor evolución.Material y métodosSe evaluaron 294 pacientes consecutivos con IA grave asintomáticos (edad media: 63 ± 7 años; 71% sexo masculino y fracción de eyección del VI [FEVI]: 64% ± 5%. Se elaboró un score basado sobre: l diámetro de fin de sístole > 24 mm/m2; 2 diámetro de fin de diástole > 36 mm/m2; 3 área del orificio regurgitante efectivo (AORE > 60 mm2; 4 diámetro de la raíz aórtica (DRA > 45 mm; 5 edad > 70 años y 6 cambio de la FEVI de reposo al ejercicio (ΔFEVI > 5%.Los puntos finales fueron: 1 sobrevida a largo plazo, 2 presencia de síntomas en el seguimiento, 3 caída de la FEVI > 5% y/o 4 cirugía valvular. El rango total del score fue de 6,5. El punto final primario fue combinado (muerte, síntomas y/o disfunción VI.ResultadosDurante un seguimiento promedio de 6,7 ± 4,2 años, 14 de 294 pacientes (4,8% fallecieron: 5 por muerte súbita, 5 por falla de bomba congestiva y 4 de causa no cardíaca. Durante el seguimiento, 88 pacientes (30% presentaron síntomas, 105 (36% disminución de la FEVI > 5% y 109 (37% fueron operados. Ciento doce (39% pacientes desarrollaron el punto final combinado.La tasa de eventos combinados (muerte, síntomas y/o caída de la FEVI con un score 3 fue del 73% ± 9%.La curva operador-receptor (ROC discriminó bien los eventos en relación con el score de riesgo: área bajo la curva de 0,93.A su vez, la tasa de cirugía valvular fue del 29% ±5% con score 3. La curva ROC discriminó bien la relación del score con la indicación de cirugía valvular: área bajo la curva de 0,96.ConclusiónEn pacientes con insuficiencia a

  8. Mass of the 158Sm

    International Nuclear Information System (INIS)

    Zhao Kui; Guo Jiyu; Lu Xiuqin; Cheng Yehao; Huang Xiaolin; Ma Yong; Li Shuyuan; Ruan Ming; Li Zhichang; Jiang Chenglie

    1997-01-01

    A preliminary result was reported for the experiment to determine the mass of the heavier neutron-rich nucleus 158 Sm using the 160 Gd( 18 O, 20 Ne) two proton transfer reaction in last progress report. The average Q-value of (4.046 +- 0.102) MeV for the 160 Gd( 18 O, 20 Ne) 158 Sm reaction is given. A mass excess for 158 Sm of (-65.738 +- 0.102) MeV was derived. This is the first experimentally measured value of the mass of 158 Sm which is about 450 keV higher than the evaluation value from systematic trends listed in the 1993 atomic mass table. The new prediction shows better agreement with the measured values and a significant improvement over the earlier FRDM (finite-range droplet model) value

  9. Biorremediación de un suelo agrícola impactado con aceite residual automotriz

    OpenAIRE

    Pasaye Anaya, Lizbeth

    2011-01-01

    El aceite residual automotriz (ARA) derivado del uso de automotores es una mezcla de hidrocarburos (HC) alifáticos, aromáticos y otros que en el suelo impide la actividad microbiana para el reciclaje de elementos esenciales para la vida. El objetivo de este trabajo fue analizar la biorremediación (BR) por bioestimulación (BS) de un suelo agrícola impactado con ARA. Para ello, el suelo contaminado con la mezcla de HC se biorremedió por BS con una solución mineral (SM), lombricomposta (LC) y ab...

  10. Studies on the preparation and stability of samarium-153 propylene diamine tetramethylene phosphonate (PDTMP) complex as a bone seeker

    International Nuclear Information System (INIS)

    Majali, M.A.; Mathakar, A.R.; Shimpi, H.H.; Banerjee, Sharmila; Samuel, Grace

    2000-01-01

    Propylene diamine tetra methylene phosphonate (PDTMP) was synthesised by modifying a method reported for the synthesis of EDTMP. Complexation of the synthesised phosphonate ligand with 153 Sm was carried out by varying the experimental parameters and the complex was radiochemically characterized. Biodistribution studies showed that the uptake by bone in rats was 2% per g of bone, which was retained up to 48 h. The uptake by other organs was insignificant, except by the liver which showed a slightly higher absorption

  11. Alternative analysis to increase the power in combined-cycle power plants; Analisis de alternativas para el incremento de potencia en plantas termoelectricas de Ciclo Combinado

    Energy Technology Data Exchange (ETDEWEB)

    Pacheco Cruz, Hector; Arriola Medellin, Alejandro M. [Gerencia de Procesos Termicos, Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)]. E-mail: hpacheco@iie.org.mx; aarriola@iie.org.mx

    2010-11-15

    The electricity industry traditionally had two thermodynamic cycles for power generation: conventional steam turbine (Rankine cycle) used to supply a base load during the day, and gas turbines (Brayton cycle), for its speed response, normally used to cover peak loads. However, to provide variable peak loads, the gas turbine, as a volumetric machine is affected by the change in air density by changing the combustion temperature. This paper shows the scheme of integration of both systems, that it's known as combined cycle and the different options that would have these power plants, to maintain or increase their power in variable ambient conditions. It analyzes different options, such as: 1. Supplementary fire in the stove. 2. Air cooling intake in the gas turbine (evaporation system or mechanical system). 3. Steam injection in the combustion chamber. [Spanish] La industria electrica tradicionalmente a contado con dos ciclos termodinamicos para generacion electrica: las turbinas convencionales de vapor (ciclo de Rankine) se utilizan para suministrar una carga base durante el dia, y las turbinas de gas (ciclo de Brayton), por su rapidez de respuesta, se utilizan normalmente para cubrir las cargas pico. Sin embargo, para suministrar las cargas variables pico, la turbina a gas, por ser una maquina volumetrica, se ve afectada por el cambio de la densidad del aire de combustion al cambiar la temperatura ambiente. En este trabajo se muestra el esquema de integracion de ambos sistemas, en lo que se conoce como ciclo combinado y las diferentes opciones que tendrian estas plantas de generacion electrica para mantener o incrementar su potencia en condiciones ambiente variable. Para ello se analizan diferentes opciones, tales como: 1.- Combustion suplementaria en el recuperador de calor. 2.- Enfriamiento del aire de admision a la turbina de gas (mediante un sistema de evaporacion o mediante un sistema mecanico). 3.- Inyeccion de vapor a la camara de combustion. Palabras

  12. Análisis de estabilidad para el rendimiento de híbridos de maíz (Zea mays en la Región Central del Litoral Ecuatoriano

    Directory of Open Access Journals (Sweden)

    Daniel Vera Aviles

    2013-01-01

    Full Text Available El objetivo de este estudio fue determinar la estabilidad de híbridos experimentales y comerciales de maíz en la Región Central del Litoral Ecuatoriano. Durante el periodo de diciembre de 2010 a abril de 2011 se evaluaron ensayos uniformes de rendimiento en cuatro localidades con ambientes contrastantes. El material genético estuvo constituido por cinco híbridos experimentales y tres comerciales. El diseño experimental utilizado fue bloques completo al azar con cuatro repeticiones, las parcelas experimentales consistieron en dos surcos de 5,0 m de largo, separados a 0,90 m. El análisis de varianza combinado propuesto por Eberhart y Russell, se encontró significancia estadística tanto como para genotipo e interacción. El rendimiento promedio mostró que entre los híbridos experimentales se destacaron el (SM45 x SSD08SV39 y (SM45 x SV15SV39 con promedios superiores a la 7,0 t ha-1, mientras que el híbrido comercial que sobresalió fue el AG-003 con rendimiento de 7,48 t ha-1. Los mejores rendimientos y los mejores índices ambientales, se registraron para las localidades de Quevedo y Vinces, los índices ambientales más bajos fueron para Balzar y Ventanas. En relación a las tendencias de respuesta de genotipos sobresalientes en los cuatro ambientes de evaluación, particularmente se observó que los genotipos son deseables, en virtud de los resultados sobresalientes tanto en los ambientes favorables como en los desfavorables.

  13. Radioisotopes and radiopharmaceuticals catalogue

    International Nuclear Information System (INIS)

    2002-01-01

    The Chilean Nuclear Energy Commission (CCHEN) presents its radioisotopes and radiopharmaceuticals 2002 catalogue. In it we found physical characteristics of 9 different reactor produced radioisotopes ( Tc-99m, I-131, Sm-153, Ir-192, P-32, Na-24, K-42, Cu-64, Rb-86 ), 7 radiopharmaceuticals ( MDP, DTPA, DMSA, Disida, Phitate, S-Coloid, Red Blood Cells In-Vivo, Red Blood Cells In-Vitro) and 4 labelled compounds ( DMSA-Tc99m, DTPA-Tc99m, MIBG-I131, EDTMP-Sm153 ). In the near future the number of items will be increased with new reactor and cyclotron products. Our production system will be certified by ISO 9000 on March 2003. CCHEN is interested in being a national and an international supplier of these products (RS)

  14. Orbitectomía en monobloque en un paciente con sarcoma neurogénico de la órbita

    Directory of Open Access Journals (Sweden)

    Franklyn Alain Abreu Perdomo

    Full Text Available El sarcoma neurogénico es un tumor maligno que se origina en las células de Schwann de la vaina del revestimiento de los nervios periféricos y son poco frecuentes en la órbita. Se presenta un paciente de 23 años de edad, masculino, blanco, con antecedentes de neurofibromatosis tipo I, con desplazamiento anteroinferior del globo ocular izquierdo, dolor intenso y pérdida de la visión de 4 meses de evolución. Al examen oftalmológico se constató proptosis severa con descenso del globo ocular izquierdo, oftalmoplejia total, quemosis severa, hiperemia, opacidad corneal y aumento de volumen del párpado superior. En los estudios imagenológicos se evidenció lesión tumoral que ocupaba la totalidad del compartimiento orbitario sin infiltración de sus paredes óseas y con desplazamiento del globo ocular por fuera del reborde orbitario. Se realizó un abordaje quirúrgico combinado, y se logró una orbitectomía en monobloque con resección total del tumor y reconstrucción con colgajo rotado de músculo temporal ipsilateral. El estudio histopatológico informó la presencia de un sarcoma neurogénico de la órbita y se complementó con tratamiento adyuvante con radioterapia. El paciente se mantuvo controlado durante un año y a partir de esta fecha comenzó la aparición secuencial de varias lesiones a distancia.

  15. Orange and reddish-orange light emitting phosphors: Sm{sup 3+} and Sm{sup 3+}/Eu{sup 3+} doped zinc phosphate glasses

    Energy Technology Data Exchange (ETDEWEB)

    Meza-Rocha, A.N., E-mail: ameza@fis.cinvestav.mx [Departamento de Física, Universidad Autónoma Metropolitana-Iztapalapa, P.O. Box 55-534, 09340 México D.F., México (Mexico); Speghini, A. [Dipartimento di Biotecnologie, Universita di Verona and INSTM, UdR Verona, Strada Le Grazie 15, I-37314 Verona (Italy); IFAC CNR, Nello Carrara Institute of Applied Physics, MDF Lab, I-50019 Sesto Fiorentino, FI (Italy); Bettinelli, M. [Dipartimento di Biotecnologie, Universita di Verona and INSTM, UdR Verona, Strada Le Grazie 15, I-37314 Verona (Italy); Caldiño, U. [Departamento de Física, Universidad Autónoma Metropolitana-Iztapalapa, P.O. Box 55-534, 09340 México D.F., México (Mexico)

    2015-11-15

    A spectroscopy study of Sm{sup 3+} and Sm{sup 3+}/Eu{sup 3+} doped zinc phosphate glasses is performed through photoluminescence spectra and decay time profile measurements. Under Sm{sup 3+} excitation at 344 nm, the Sm{sup 3+} singly doped glass shows an orange global emission with x=0.579 and y=0.414 CIE1931 chromaticity coordinates, whereas the Sm{sup 3+}/Eu{sup 3+} co-doped sample exhibits orange overall emissions (x=0.581 and y=0.398, and x=0.595 and y=0.387) and reddish-orange overall emission (x=0.634 and y=0.355) upon excitations at 344, 360 and 393 nm, respectively. Such luminescence from the co-doped sample is originated by the simultaneous emission of Sm{sup 3+} and Eu{sup 3+}. Under Sm{sup 3+} excitation at 344 and 360 nm, the Eu{sup 3+} emission is sensitized and enhanced by Sm{sup 3+} through a non-radiative energy transfer process. The non-radiative nature was inferred from the shortening of the Sm{sup 3+} lifetime observed in the Sm{sup 3+}/Eu{sup 3+} co-doped sample. An analysis of the Sm{sup 3+} emission decay time profiles using the Inokuti–Hirayama model suggests that an electric quadrupole–quadrupole interaction into Sm–Eu clusters might dominate the energy transfer process, with an efficiency of 0.17. - Highlights: • Zinc phosphate glasses are optically activated with Sm{sup 3+}/Eu{sup 3+} (ZPOSmEu). • Non-radiative energy transfer Sm{sup 3+}→Eu{sup 3+} takes place in ZPOSmEu. • ZPOSmEu overall emission can be modulated with the excitation wavelength. • ZPOSmEu might be useful as orange/reddish-orange phosphor for UV-white LEDs.

  16. Probing metastable Sm2+ and optically stimulated tunnelling emission in YPO4: Ce, Sm

    DEFF Research Database (Denmark)

    Prasad, Amit Kumar; Kook, Myung Ho; Jain, Mayank

    2017-01-01

    When the model dosimetry system YPO4: Ce3+, Sm3+ is exposed to X-rays, the charge state of the dopants changes, becoming Ce4+ and Sm2+ via hole and electron trapping, respectively which are metastable; the original charge states can be achieved through electron transfer back from Sm2+ to Ce4+ via......) and its temperature dependence to provide insights into thermal quenching, and c) the kinetics of localised recombination from Sm2+ to Ce4+ on nanoseconds to seconds time scales using sub-band-edge excitation....

  17. Impacto del síndrome metabólico en la resistencia a la recanalización arterial y en el pronóstico de los pacientes con oclusión aguda de la arteria cerebral media tratados con activador tisular del plasminógeno

    OpenAIRE

    Dorado Bouix, Laura

    2012-01-01

    La recanalización arterial precoz es un punto clave para alcanzar un buen pronóstico funcional tras un ictus isquémico. El síndrome metabólico (SM) podría jugar un papel en la evolución de los pacientes con ictus isquémico tratados con activador tisular del plasminógeno (tPA) por vía sistémica (a) por su asociación a un estado protrombótico que podría interferir en la recanalización arterial inducida por tPA y (b) porque varias de las alteraciones metabólicas que acompañan al SM podrían contr...

  18. Luminescence properties of the Sm-doped borate glasses

    International Nuclear Information System (INIS)

    Kindrat, I.I.; Padlyak, B.V.; Drzewiecki, A.

    2015-01-01

    The optical absorption and photoluminescence (emission and excitation) spectra as well as decay kinetics of a series of the Sm-doped glasses with Li 2 B 4 O 7 , LiKB 4 O 7 , CaB 4 O 7 , and LiCaBO 3 compositions were investigated and analysed. The Li 2 B 4 O 7 :Sm, LiKB 4 O 7 :Sm, CaB 4 O 7 :Sm, and LiCaBO 3 :Sm glasses of high optical quality have been obtained from the corresponding polycrystalline compounds in the air atmosphere, using a standard glass technology. On the basis of electron paramagnetic resonance (EPR) and optical spectra analysis it was shown that the samarium impurity is incorporated into the glass network as Sm 3+ (4f 5 , 6 H 5/2 ) ions, exclusively. All observed 4f – 4f transitions of the Sm 3+ centres in the optical absorption and luminescence spectra of the investigated glasses are identified. Most intense emission band of the Sm 3+ ions peaked about 598 nm ( 4 G 5/2 → 6 H 7/2 transition) is characterised by a single exponential decay with typical lifetime values, which depend on the basic glass composition as well as concentration and local structure of the Sm 3+ luminescence centres. The quantum efficiency has been evaluated for observed transitions of the Sm 3+ centres using obtained experimental lifetimes and radiative lifetimes calculated by Judd–Ofelt theory. The calculated high quantum efficiencies and measured quantum yields of luminescence show that the investigated borate glasses are perspective luminescence materials. Energy transfer from the Ce 3+ non-controlled impurity and intrinsic luminescence centres to the Sm 3+ centres has been observed. Peculiarities of the Sm 3+ local structure in the network of investigated glasses have been discussed based on the obtained spectroscopic results and structural data. - Highlights: • The Sm-doped Li 2 B 4 O 7 , LiKB 4 O 7 , CaB 4 O 7 , and LiCaBO 3 glasses of high quality were obtained. • EPR, optical absorption and luminescence spectra of Sm 3+ ions in obtained glasses were

  19. Cross-species prophylactic efficacy of Sm-p80-based vaccine and intracellular localization of Sm-p80/Sm-p80 ortholog proteins during development in Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium.

    Science.gov (United States)

    Molehin, Adebayo J; Sennoune, Souad R; Zhang, Weidong; Rojo, Juan U; Siddiqui, Arif J; Herrera, Karlie A; Johnson, Laura; Sudduth, Justin; May, Jordan; Siddiqui, Afzal A

    2017-11-01

    Schistosomiasis remains a major global health problem. Despite large-scale schistosomiasis control efforts, clear limitations such as possible emergence of drug resistance and reinfection rates highlight the need for an effective schistosomiasis vaccine. Schistosoma mansoni large subunit of calpain (Sm-p80)-based vaccine formulations have shown remarkable efficacy in protecting against S. mansoni challenge infections in mice and baboons. In this study, we evaluated the cross-species protective efficacy of Sm-p80 vaccine against S. japonicum and S. haematobium challenge infections in rodent models. We also elucidated the expression of Sm-p80 and Sm-p80 ortholog proteins in different developmental stages of S. mansoni, S. haematobium, and S. japonicum. Immunization with Sm-p80 vaccine reduced worm burden by 46.75% against S. japonicum challenge infection in mice. DNA prime/protein boost (1 + 1 dose administered on a single day) resulted in 26.95% reduction in worm burden in S. haematobium-hamster infection/challenge model. A balanced Th1 (IFN-γ, TNF-α, IL-2, and IL-12) and Th2 (IL-4, IgG1) type of responses were observed following vaccination in both S. japonicum and S. haematobium challenge trials and these are associated with the prophylactic efficacy of Sm-p80 vaccine. Immunohistochemistry demonstrated that Sm-p80/Sm-p80 ortholog proteins are expressed in different life cycle stages of the three major human species of schistosomes studied. The data presented in this study reinforce the potential of Sm-p80-based vaccine for both hepatic/intestinal and urogenital schistosomiasis occurring in different geographical areas of the world. Differential expression of Sm-p80/Sm-p80 protein orthologs in different life cycle makes this vaccine potentially useful in targeting different levels of infection, disease, and transmission.

  20. Desarrollo de técnicas combinadas de secado para la obtención de duraznos deshidratados con bajo contenido de sulfitos

    Directory of Open Access Journals (Sweden)

    URFALINO, D.P.

    2011-08-01

    Full Text Available En el deshidratado de durazno, la aplicación de dióxido de azufre (SO2 juega un importante rol por su efecto antioxidante y conservante. Sin embargo el SO2 y los sulfitos presentan efectos indeseados en la salud de los consumidores: reducen la asimilación de la vitamina B1 y pueden provocar dolores de cabeza crónicos, alteraciones en la memoria y constricciones bronquiales (mayormente en personas asmáticas. Los alimentos tratados con sulfitos son la principal fuente de ingesta del SO2, siendo difícil su reducción o sustitución por el consecuente cambio en las propiedades sensoriales de los mismos, sobre todo en color y sabor. Así, los consumidores podrían rechazar dichas alternativas, a pesar de que éstas pudieran considerarse más saludables. El presente trabajo tuvo por objetivo lograr un producto con bajos contenidos de SO2 a través deldesarrollo de nuevos métodos de procesado e inactivación enzimática sin perder de vista su calidad. Como primera alternativa se evaluó la aplicación de microondas y escaldado con agua caliente como métodos deinactivación de la polifenoloxidasa y la peroxidasa. Por otro lado, se evaluó el deshidratado osmótico combinado con secado convectivo, comparándolo con el secado convectivo tradicional. Como parámetros de calidad en los productos finales se utilizó la velocidad de deshidratado, el color y el contenido residual de sulfitos. Los métodos de inactivación enzimática ensayados no presentaron diferencias significativas, mientras que la combinación de deshidratado osmótico con secado convectivo presentó ventajas respecto al secado convectivo tradicional, logrando un producto con un contenido significativamente menor de sulfitos, excelentecolor y mejores características organolépticas que los productos tradicionales (mayor volumen, mejor palatabilidad. Si bien el secado tradicional presentó tiempos de proceso totales menores al secado combinado, la calidad del producto final

  1. Impacto de la asesoría sobre anticoncepción en la selección de métodos hormonales combinados en Colombia

    Directory of Open Access Journals (Sweden)

    Pío Gómez Sánchez

    2015-06-01

    Full Text Available OBJETIVO: Determinar el impacto de la asesoría anticonceptiva informada sobre la elección de método anticonceptivo. MÉTODOS: Estudio descriptivo multicéntrico de evaluación antes y después en nueve ciudades de Colombia. Se invitó a participar mujeres que consideraban usar métodos hormonales combinados de autoadministración al momento de la consulta. Se indagó sobre el uso y preferencia de método anticonceptivo, previa firma del consentimiento informado. En una etapa posterior, se brindó asesoría médica estandarizada en anticoncepción y, a continuación, se preguntó nuevamente por la preferencia de método anticonceptivo y las motivaciones para su elección. RESULTADOS: Ingresaron 858 mujeres al estudio. Al inicio del estudio, 538 (62,7% mujeres usaban píldora combinada y 281 (32,8% no utilizaban ningún método anticonceptivo. Antes de recibir asesoría, las mujeres mostraron una preferencia por la píldora (62,7%, seguida por el anillo intravaginal (28,4% y el parche transdérmico (14%. Luego de la asesoría, la preferencia fue la siguiente: píldora (40,8%, anillo intravaginal (31,5% y parche transdérmico (11,3%. También luego de la asesoría, 32,5 %, 26,8% y 7,5% de las que consideraban usar píldora, parche y anillo, respectivamente, cambiaron su intención de uso. La región de origen, el estatus laboral, el deseo de concebir un hijo en el futuro y tener una relación estable presentaron una relación estadística con la selección del método, pero la edad, el número de hijos o el grado de escolaridad no fueron factores determinantes. CONCLUSIONES: La asesoría médica tiene impacto en la selección del anticonceptivo hormonal combinado autoadministrado, lo que ayuda a las mujeres a utilizar el método de su preferencia y presentar una mejor adherencia al método acorde a sus condiciones particulares.

  2. Study of fuel element characteristic of SM and SMP (SM-PRIMA) fuel assemblies

    International Nuclear Information System (INIS)

    Klinov, A.V.; Kuprienko, V.A.; Lebedev, V.A.; Makhin, V.M.; Tuchnin, L.M.; Tsykanov, V.A.

    1999-01-01

    The paper discusses the techniques and results of reactor tests and post-reactor investigations of the SM reactor fuel elements and fuel elements developed in the process of designing the specialized PRIMA test reactor with the SM reactor fuel elements used as a prototype and which are referred to as the SMP fuel elements. The behavior of fuel elements under normal operating conditions and under deviation from normal operating conditions was studied to verify the calculation techniques, to check the calculation results during preparation of the SM reactor safety substantiation report and to estimate the possibility of using such fuel elements in other projects. During tests of fuel rods under deviation from normal operating conditions their advantages were shown over fuel elements, the components of which were produced using the Al-based alloys. (author)

  3. Análisis multifactorial de varianza del desempeño de un jobshop dinámico con due dates basado en regresión múltiple

    Directory of Open Access Journals (Sweden)

    Marcos Neira Rodriguez

    2008-04-01

    Full Text Available Se realiza un análisis de varianza mult1factorial del desempeño global de un sistema de producción tipo taller con centros de trabajo de multicapacidad (flexible jobshop , considerando los factores regla de despacho , balance de centros de trabajo y proporción de due dates fijados externamente . El desempeño del sistema, observado mediante simulación, se evalúa a través de una medida que pondera el atraso absoluto y el tiempo de flujo. Los due dates son fijados internamente a través de regresión lineal múltiple. Los resultados estadísticos muestran que los tres factores son significativos en el desempeño del sistema, y que en escenarios donde ambas medidas tienen igual ponderación, si los due dates son fijados internamente FIFO y SPT produ­ cen mejores resultados, mientras que en presencia de due dates fijados externamente . EDD combinado con FIFO (EDD combinado con TWKR es la mejor alternativa para el caso balan­ ceado (desbalanceado . A multifactorial analysis of variance of the performance of a jobshop like production system with multicapacity (flexiblejobshop is realized,by considering the factors dispatching rule, workstation capacity balance and proportion of due dates setting done externally. The system performance , observed by simulation, is evaluated by a measure that weight the absolute lateness and the flow time. Due dates setting is done intemally by multiple linear regression.The results shows that the three factors are significant with respect to the system performance, and in scenarios in which both measures are equally weighted, if the due dates setting is done intemally FIFO and SPT produces better results, while in presence of externally due date setting, EDD combined with FIFO (EDD combined with TWKR is the better alternative for the balanced (unbalanced case.

  4. Luminescence properties of the Sm-doped borate glasses

    Energy Technology Data Exchange (ETDEWEB)

    Kindrat, I.I. [University of Zielona Góra, Institute of Physics, Division of Spectroscopy of Functional Materials, 4a Szafrana Street, 65-516 Zielona Góra (Poland); Padlyak, B.V., E-mail: B.Padlyak@if.uz.zgora.pl [University of Zielona Góra, Institute of Physics, Division of Spectroscopy of Functional Materials, 4a Szafrana Street, 65-516 Zielona Góra (Poland); Vlokh Institute of Physical Optics, 23 Dragomanov Street, 79-005 Lviv (Ukraine); Drzewiecki, A. [University of Zielona Góra, Institute of Physics, Division of Spectroscopy of Functional Materials, 4a Szafrana Street, 65-516 Zielona Góra (Poland)

    2015-10-15

    The optical absorption and photoluminescence (emission and excitation) spectra as well as decay kinetics of a series of the Sm-doped glasses with Li{sub 2}B{sub 4}O{sub 7}, LiKB{sub 4}O{sub 7}, CaB{sub 4}O{sub 7}, and LiCaBO{sub 3} compositions were investigated and analysed. The Li{sub 2}B{sub 4}O{sub 7}:Sm, LiKB{sub 4}O{sub 7}:Sm, CaB{sub 4}O{sub 7}:Sm, and LiCaBO{sub 3}:Sm glasses of high optical quality have been obtained from the corresponding polycrystalline compounds in the air atmosphere, using a standard glass technology. On the basis of electron paramagnetic resonance (EPR) and optical spectra analysis it was shown that the samarium impurity is incorporated into the glass network as Sm{sup 3+} (4f{sup 5}, {sup 6}H{sub 5/2}) ions, exclusively. All observed 4f – 4f transitions of the Sm{sup 3+} centres in the optical absorption and luminescence spectra of the investigated glasses are identified. Most intense emission band of the Sm{sup 3+} ions peaked about 598 nm ({sup 4}G{sub 5/2} → {sup 6}H{sub 7/2} transition) is characterised by a single exponential decay with typical lifetime values, which depend on the basic glass composition as well as concentration and local structure of the Sm{sup 3+} luminescence centres. The quantum efficiency has been evaluated for observed transitions of the Sm{sup 3+} centres using obtained experimental lifetimes and radiative lifetimes calculated by Judd–Ofelt theory. The calculated high quantum efficiencies and measured quantum yields of luminescence show that the investigated borate glasses are perspective luminescence materials. Energy transfer from the Ce{sup 3+} non-controlled impurity and intrinsic luminescence centres to the Sm{sup 3+} centres has been observed. Peculiarities of the Sm{sup 3+} local structure in the network of investigated glasses have been discussed based on the obtained spectroscopic results and structural data. - Highlights: • The Sm-doped Li{sub 2}B{sub 4}O{sub 7}, LiKB{sub 4}O{sub 7}, Ca

  5. Multicentre trial on the efficacy and toxicity of single-dose samarium-153-ethylene diamine tetramethylene phosphonate as a palliative treatment for painful skeletal metastases in China

    International Nuclear Information System (INIS)

    Tian Jia-he; Zhang Jin-ming; He Yi-jie; Hou Qing-tian; Oyang Qiao-hong; Wang Jian-min; Chuan Ling

    1999-01-01

    A multicentre trial was organized in China as part of an international coordinated research project to study the efficacy and toxicity of single-dose samarium-153 ethylene diamine tetramethylene phosphonate (EDTMP) as a palliative treatment for painful skeletal metastases. One hundred and five patients with painful bone metastases from various primaries were treated with 153 Sm-EDTMP at a dose of 37 MBq/kg(group I) or 18.5 MBq/kg (group II). The effects were evaluated according to change in daily analgesic consumption, pain score, sum of effect product (SEP), Physician's Global Assessment (PGA), blood counts, and organ function tests conducted regularly for 16 weeks. Fifty-eight of 70 patients in group I and 30 of 35 in group II had a positive response, with SEPs of 22.29±14.47 and 20.13±13.90 respectively. Of 72 patients who had been receiving analgesics, 63 reduced their consumption. PGA showed that the Karnofsky score (KS) increased from 58.54±25.90 to 71.67±26.53, indicating improved general condition, but the difference was not significant. Among subgroups of patients, only those with breast cancer showed a significant change in the Karnofsky score after treatment. Inter-group differences were found for net change in KS between patients with lung and patients with breast cancer, and between patients with lung and patients with oesophageal cancer. Seventeen patients showed no response. No serious side-effects were noted, except for falls in the white blood cell (nadir 1.5 x 10 9 /l) and platelet (nadir 6.0 x 10 10 /l) counts in 44/105 and 34/105 cases, respectively. Ten patients had an abnormal liver function test. Response and side-effects were both independent of dose. In conclusion, 153 Sm-EDTMP provided effective palliation in 83.8% of patients with painful bone metastases; the major toxicity was temporary myelosuppression. Further studies are needed to identify better ways of determining the appropriate dose in the individual case and the efficacy of

  6. Kampen om det sibiriske smør

    DEFF Research Database (Denmark)

    Larsen, Inge Marie

    2001-01-01

    Afhandlingen følger opbygningen af og udviklingen i den vestsibiriske smørsektor og den internationale handel med sibirisk smør. Hvordan gik det til, at Rusland blev verdens næststørste smøreksportør? Indfaldsvinkelen er lokal sibirisk, national russisk og global, idet danske og engelske firmaers...

  7. Riesgo cardiovascular en población infantil con sobrepeso y obesidad

    Directory of Open Access Journals (Sweden)

    Jaime Pajuelo R.

    2013-07-01

    Full Text Available Introducción: El sobrepeso y la obesidad conducen a la aparición de comorbilidades como la diabetes mellitus tipo 2, hipertensión arterial, dislipidemias. Objetivos: Determinar la presencia de riesgo cardiovascular en niños y adolescentes con sobrepeso y obesidad, por género y grupos de edad. Diseño: Estudio descriptivo, transversal. Participantes: Niños y adolescentes, de ambos géneros, comprendidos entre los 5 a 18 años. Intervención: El diagnóstico de sobrepeso y obesidad se hizo de acuerdo a la clasificación de Must y col. con los siguientes criterios: de 85 a 95 para el sobrepeso y más de 95 percentil obesidad. En sangre se determinó el perfil lipídico, glucosa e insulina; con estas dos últimas se determinó el índice HOMA, para identificar resistencia a la insulina (RI, mediante la ecuación de Matthew, el síndrome metabólico (SM con la referencia de Cook y las dislipidemias (D con las sugerencias de Friedman y de Daniels. Principales medidas de resultados: Riesgo cardiovascular. Resultados: Los obesos presentan mayores riesgos cardiovasculares que los que tienen sobrepeso: RI 77,8%, SM 22,2%; D: colesterol total (CT 64,4%, C-HDL 33,3%, C-LDL 19,5% y triglicéridos (Tg 40%. El género masculino, independientemente de su estado nutricional, tuvo mayor riesgo que el femenino: RI 74,1%, SM 22,2%, D: CT 63%, C-HDL 37%, C-LDL 36% y Tg 40,7%. En cuanto a la edad, en los mayores de 10 años se ha encontrado RI en 78% y C-HDL 31,7%; los demás factores de riesgo fueron mayores en los menores de 10 años. Conclusiones: Los riesgos afectaron más a los obesos que a los que tenían sobrepeso, más al género masculino y, en cuanto a la edad, los mayores de 10 años presentaron mayor prevalencia de RI y de C-HDL bajo. A mayor IMC más riesgo cardiovascular, lo que compromete muy seriamente la salud y que se hace más preocupante porque su aparición es a temprana edad.

  8. Uso do bloqueio combinado raqui-peridural durante cirurgia de cólon em paciente de alto risco: relato de caso Uso del bloqueo combinado raquiepidural durante cirugía de colon en paciente de alto riesgo: relato de caso Combined spinal epidural anesthesia during colon surgery in a high-risk patient: case report

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo Imbelloni

    2009-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O bloqueio combinado raqui-peridural (BCRP oferece vantagens sobre a anestesia peridural ou subaracnóidea com injeção única. O objetivo deste relato foi apresentar um caso onde a anestesia subaracnóidea segmentar pode ser técnica efetiva para intervenção cirúrgica gastrintestinal com respiração espontânea. RELATO DO CASO: Paciente estado físico ASA III, diabetes mellitus tipo II, com hipertensão arterial sistêmica e doença pulmonar obstrutiva crônica, foi escalada para ressecção de tumor de cólon direito. O BCRP foi realizado no interespaço T5 - T6 e foram injetados 8 mg de bupivacaína a 0,5% isobárica acrescida de 50 µg de morfina no espaço subaracnóideo. O cateter peridural (20G foi introduzido quatro centímetros em direção cefálica. Foi obtida sedação com doses fracionadas de 1 mg de midazolam (total de 6 mg. Bupivacaína a 0,5% foi administrada em bolus de 25 mg através do cateter duas horas após a anestesia subaracnóidea. Não houve necessidade de vasopressor nem atropina. CONCLUSÕES: Este caso proporciona evidências de que a raquianestesia segmentar pode ser uma técnica anestésica para operação gastrintestinal com respiração espontânea.JUSTIFICATIVA Y OBJETIVOS: El bloqueo combinado raquiepidural (BCRE, tiene ventajas sobre la anestesia epidural o subaracnoidea con inyección única. El objetivo de este relato, fue presentar un caso donde la anestesia subaracnoidea segmentaria, puede ser una técnica efectiva para la intervención quirúrgica gastrointestinal con respiración espontánea. RELATO DEL CASO: Paciente estado físico ASA III, diabetes mellitus tipo II, con hipertensión arterial sistémica y enfermedad pulmonar obstructiva crónica, que fue indicada para la resección del tumor de colon derecho. El BCRE se realizó en el interespacio T5 - T6, y se inyectaron 8 mg de bupivacaína a 0,5% isobárica con 50 µg más de morfina en el espacio subaracnoideo. El cat

  9. Ciclo combinado Diesel-Vapor como repotenciación de una central termoeléctrica: caso de estudio; Combined Cycle Diesel-Steam as Power Plant Repowering: study case

    Directory of Open Access Journals (Sweden)

    Alberto Eduardo Calvo González

    2015-04-01

    Full Text Available La necesidad imperiosa de cubrir el déficit de generación eléctrica ampliando el potencial de generación con motores diesel a fuel oíl, cuya instalación requiere de muy poco tiempo, es una solución adecuada. La idea de aprovechar los nodos del sistema electro energético, como son las subestaciones y las centrales eléctricas, para instalar los grupos electrógenos es una solución apropiada. Pero en el caso de una central termoeléctrica, al montar estas instalaciones de forma independiente, no se aprovechan las posibilidades que la combinación de procesos ofrece como la disminución del consumo de combustible, y de la contaminación ambiental por unidad de energía producida. El presente trabajo explora la posibilidad de instalar plantas eléctricas diesel a fuel oil como ciclo combinado diesel-vapor. Se demuestra la conveniencia de instalar plantas eléctricas diesel a fuel oil como ciclo combinado diesel-vapor, aprovechando la sinergia que se logra por la combinación de los procesos térmicos.  The pressing need of covering generation deficit to satisfy the demand in the shorter possible time, by enlarging the generation potential with fuel oil fueled diesel motors, it’s an appropriate solution. The idea of taking advantage of electric grid existent nodes facilities to place the generating electricity diesel motors is a non-unwise solution. But in the case of the node of steam power station place these motors in an independent way, don't take advantage of the possibilities that the processes combination offers, as the combined cycle diesel vapor for example. The work presented herein explored and showed the possibility of installing the electric diesel plants as a repowering the existing steam power plant by combined cycle diesel-steam taking advantage of the synergy achieved by thermal processes combination.

  10. Ciclo combinado Diesel-Vapor como repotenciación de una central termoeléctrica: caso de estudio; Combined Cycle Diesel-Steam as Power Plant Repowering: study case

    Directory of Open Access Journals (Sweden)

    Alberto Eduardo Calvo González

    2014-06-01

    Full Text Available La necesidad imperiosa de cubrir el déficit de generación eléctrica ampliando el potencial de generación con motores diesel a fuel oíl, cuya instalación requiere de muy poco tiempo, es una solución adecuada. La idea de aprovechar los nodos del sistema electro energético, como son las subestaciones y las centrales eléctricas, para instalar los grupos electrógenos es una solución apropiada. Pero en el caso de una central termoeléctrica, al montar estas instalaciones de forma independiente, no se aprovechan las posibilidades que la combinación de procesos ofrece como la disminución del consumo de combustible, y de la contaminación ambiental por unidad de energía producida. El presente trabajo explora la posibilidad de instalar plantas eléctricas diesel a fuel oil como ciclo combinado diesel-vapor. Se demuestra la conveniencia de instalar plantas eléctricas diesel a fuel oil como ciclo combinado diesel-vapor, aprovechando la sinergia que se logra por la combinación de los procesos térmicos. The pressing need of covering generation deficit to satisfy the demand in the shorter possible time, by enlarging the generation potential with fuel oil fueled diesel motors, it’s an appropriate solution. The idea of taking advantage of electric grid existent nodes facilities to place the generating electricity diesel motors is a non-unwise solution. But in the case of the node of steam power station place these motors in an independent way, don't take advantage of the possibilities that the processes combination offers, as the combined cycle diesel vapor for example. The work presented herein explored and showed the possibility of installing the electric diesel plants as a repowering the existing steam power plant by combined cycle diesel-steam taking advantage of the synergy achieved by thermal processes combination.

  11. AVALIAÇÃO DO DESEMPENHO DOS SISTEMAS GPS E GLONASS NO POSICIONAMENTO POR PONTO PRECISO, COMBINADOS E INDIVIDUALMENTE.

    Directory of Open Access Journals (Sweden)

    Bruno Guimarães Ventorim

    Full Text Available Este trabalho visa avaliar o desempenho dos sistemas GLONASS (Global'naya Navigatsionnay Sputnikovaya Sistema, GPS (Global Positioning System e o uso combinado de ambos sistemas em diferentes latitudes, utilizando o serviço de Posicionamento por Ponto Preciso CSRS-PPP. Para isso foram selecionadas 16 estações da rede IGS (International GNSS Service, das quais foram utilizados os dados GNSS no formato RINEX do mês de agosto de 2014 e editados no TEQC (Translation, Editing, and Quality Check, obtendo arquivos com intervalos de 30 e 45 minutos, contendo apenas dados GPS, dados GLONASS e dados dos dois sistemas. As coordenadas estimadas no CSRS-PPP foram comparadas com as coordenadas de referência obtidas no sítio do ITRF (International Terrestrial Reference Frame, possibilitando o cálculo da acurácia do PPP com uso de dados GPS e GLONASS, separadamente e em conjunto. Após o cálculo das acurácias para cada dia de agosto, outliers foram detectados e eliminados utilizando o método boxplot com o uso do programa R. Verificou-se que o uso combinado do GPS e GLONASS, para todos as estações, proporcionou resultados mais acurados. Além disso, pode-se destacar a potencialidade do GLONASS, que apresentou desempenho superior ao do GPS na maioria das estações.

  12. Curie temperature rising by fluorination for Sm2Fe17

    Directory of Open Access Journals (Sweden)

    Matahiro Komuro

    2013-02-01

    Full Text Available Fluorine atoms can be introduced to Sm2Fe17 using XeF2 below 423 K. The resulting fluorinated Sm2Fe17 powders have ferromagnetic phases containing Sm2Fe17FY1(0Sm2Fe17FY2 (1Sm2Fe17, and α-Fe. The unit cell for Sm2Fe17 is elongated by the fluorination. The largest unit cell volume among the rhombohedral Sm2Fe17 compounds is 83.8 nm3, which is 5.8% larger than Sm2Fe17. The rhombohedral Sm2Fe17 with the largest unit cell volume is dissociated above 873 K, and fluorination increases Curie temperature from 403 K for Sm2Fe17 to 675 K. This increase can be explained by the magneto-volume effect.

  13. DNA Vaccine Encoding the Chimeric Form of Schistosoma mansoni Sm-TSP2 and Sm29 Confers Partial Protection against Challenge Infection.

    Directory of Open Access Journals (Sweden)

    Natan Raimundo Gonçalves de Assis

    Full Text Available Schistosomiasis is an important parasitic disease worldwide that affects more than 207 million people in 76 countries and causes approximately 250,000 deaths per year. The best long-term strategy to control schistosomiasis is through immunization combined with drug treatment. Due to the ability of DNA vaccines to generate humoral and cellular immune responses, such vaccines are considered a promising approach against schistosomiasis. Sm29 and tetraspanin-2 (Sm-TSP2 are two proteins that are located in the S. mansoni tegument of adult worms and schistosomula and induce high levels of protection through recombinant protein immunization. In this study, we transfected BHK-21 cells with plasmids encoding Sm29, Sm-TSP2 or a chimera containing both genes. Using RT-PCR analysis and western blot, we confirmed that the DNA vaccine constructs were transcribed and translated, respectively, in BHK-21 cells. After immunization of mice, we evaluated the reduction in worm burden. We observed worm burden reductions of 17-22%, 22%, 31-32% and 24-32% in animals immunized with the pUMVC3/Sm29, pUMVC3/SmTSP-2, pUMVC3/Chimera and pUMVC3/Sm29 + pUMVC3/SmTSP-2 plasmids, respectively. We evaluated the humoral response elicited by DNA vaccines, and animals immunized with pUMVC3/Sm29 and pUMVC3/Sm29 + pUMVC3/SmTSP-2 showed higher titers of anti-Sm29 antibodies. The cytokine profile produced by the spleen cells of immunized mice was then evaluated. We observed higher production of Th1 cytokines, such as TNF-α and IFN-γ, in vaccinated mice and no significant production of IL-4 and IL-5. The DNA vaccines tested in this study showed the ability to generate a protective immune response against schistosomiasis, probably through the production of Th1 cytokines. However, future strategies aiming to optimize the protective response induced by a chimeric DNA construct need to be developed.

  14. DNA Vaccine Encoding the Chimeric Form of Schistosoma mansoni Sm-TSP2 and Sm29 Confers Partial Protection against Challenge Infection

    Science.gov (United States)

    Gonçalves de Assis, Natan Raimundo; Batistoni de Morais, Suellen; Figueiredo, Bárbara Castro Pimentel; Ricci, Natasha Delaqua; de Almeida, Leonardo Augusto; da Silva Pinheiro, Carina; Martins, Vicente de Paulo; Oliveira, Sergio Costa

    2015-01-01

    Schistosomiasis is an important parasitic disease worldwide that affects more than 207 million people in 76 countries and causes approximately 250,000 deaths per year. The best long-term strategy to control schistosomiasis is through immunization combined with drug treatment. Due to the ability of DNA vaccines to generate humoral and cellular immune responses, such vaccines are considered a promising approach against schistosomiasis. Sm29 and tetraspanin-2 (Sm-TSP2) are two proteins that are located in the S. mansoni tegument of adult worms and schistosomula and induce high levels of protection through recombinant protein immunization. In this study, we transfected BHK-21 cells with plasmids encoding Sm29, Sm-TSP2 or a chimera containing both genes. Using RT-PCR analysis and western blot, we confirmed that the DNA vaccine constructs were transcribed and translated, respectively, in BHK-21 cells. After immunization of mice, we evaluated the reduction in worm burden. We observed worm burden reductions of 17-22%, 22%, 31-32% and 24-32% in animals immunized with the pUMVC3/Sm29, pUMVC3/SmTSP-2, pUMVC3/Chimera and pUMVC3/Sm29 + pUMVC3/SmTSP-2 plasmids, respectively. We evaluated the humoral response elicited by DNA vaccines, and animals immunized with pUMVC3/Sm29 and pUMVC3/Sm29 + pUMVC3/SmTSP-2 showed higher titers of anti-Sm29 antibodies. The cytokine profile produced by the spleen cells of immunized mice was then evaluated. We observed higher production of Th1 cytokines, such as TNF-α and IFN-γ, in vaccinated mice and no significant production of IL-4 and IL-5. The DNA vaccines tested in this study showed the ability to generate a protective immune response against schistosomiasis, probably through the production of Th1 cytokines. However, future strategies aiming to optimize the protective response induced by a chimeric DNA construct need to be developed. PMID:25942636

  15. Resultados de un análisis combinado en el Falsacionismo Metodológico

    Directory of Open Access Journals (Sweden)

    Enrique César Paz

    2013-11-01

    Full Text Available Existe un problema cuando cierta clase de sentencia judicial pecuniariamente condenatoria no se ejecuta luego de su dictado de manera inmediata sino que transcurre, como es normal, un largo tiempo, hasta que por fin logra ser cumplida. Durante ese período -que transcurre desde que la sentencia es dictada hasta que por fin la misma es cumplida- el poder adquisitivo de compra de bienes y servicios que representa el monto dinerario establecido al momento de dictar la sentencia sufre variaciones en más o en menos, según hablemos de deflación o inflación. Por lo tanto, no será lo mismo para ninguna de la partes (actor y demandado que la sentencia se cumpla al momento de ser dictada que luego de, por ejemplo, 5 años. Destaco las razones por las cuales debe garantizarse el mantenimiento incólume del contenido económico de la sentencia y lograrse, además, el reconocimiento de una rentabilidad real razonable a favor de la persona que fue privada de su capital (actor durante el período que medió entre el dictado de la sentencia y el cumplimiento de la misma. Con el fin de lograr cumplimentar dichos objetivos busco un mecanismo adecuado, valiéndome de las herramientas de la matemática financiera, formulando hipótesis y refutándolas, hasta hallar al mecanismo correcto, en el cual distingo la “constante” de la “variable”. Demuestro las falencias que reflejan los sistemas que se aplican en la actualidad, y creo diversos niveles de eficacia de dichas sentencias, entre otras conclusiones y propuestas que logro desarrollar. Abordo el trabajo utilizado el “falsacionismo metodológico”, y me baso en la elemental relación entre la matemática financiera y esta clase de sentencias judiciales, relación que justifica el análisis combinado desarrollado en el presente trabajo. 

  16. Simulador interativo de estabilidade de usinas termelÃtricas de ciclo combinado para projetos, pesquisa e treinamento

    OpenAIRE

    Gabriel Josà Alves dos Santos

    2012-01-01

    Neste trabalho foi desenvolvido o estudo e as aplicaÃÃes das condiÃÃes de estabilidade na operaÃÃo do sistema elÃtrico de potÃncia incorporado em um simulador interativo de usinas termelÃtricas de ciclo combinado, que permita melhorar os processos de treinamento e, consequentemente, o nÃvel de qualidade dos futuros operadores e mantenedores de usinas termelÃtricas, bem como manter atualizados os atuais operadores. Um pequeno conjunto de definiÃÃes e conceitos das Ãreas de âestabilidade, confi...

  17. Diffuse control of gas turbines in power stations of combined cycle; Contral difuso de turbinas de gas en centrales de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez P, Marino; Garduno R, Raul; De Lara J, Salvadror; Castelo C, Luis [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2001-07-01

    In this article the application of the technology of the fuzzy logic to the control of gas turbines is presented in order to evaluate it in one of the most difficult processes and with stricter control requirements that exist in the electrical generation industry. For being important for the generation electrical sector, given their use in Comision Federal de Electricidad (CFE), the first selected prototype was the gas turbines model W501 of Westinghouse, installed in the of combined cycle power stations of Dos Bocas, Veracruz, Gomez Palacio, Durango and Tula, Hidalgo, Mexico. The second selected prototype was the one of the turbo gas units type 5001 (that applies to the GE 5001 models and Westinghouse of series 191 and 251). Based on the analysis of the performance of the system of conventional control previously made, the controllers of speed and generation of electrical power were selected to be replaced by diffuse controllers. [Spanish] En este articulo se presenta la aplicacion de la tecnologia de la logica difusa al control de turbinas de gas con el proposito de evaluarla en uno de los procesos mas dificiles y con requerimientos mas estrictos de control que existen en la industria de generacion electrica. Por ser importantes para el sector electrico de generacion, dada su utilizacion en Comision Federal de Electricidad (CFE), el primer prototipo seleccionado fueron las turbinas de gas modelo W501 de Westinghouse, instaladas en la central de ciclo combinado de Dos Bocas, Veracruz, Gomez Palacio, Durango y Tula, Hidalgo, Mexico. El segundo prototipo seleccionado fue el de unidades turbogas tipo 5001 (que aplica a los modelos GE 5001 y Westinghouse de la serie 191 y 251). Basados en el analisis del desempeno del sistema de control convencional realizado previamente, los controladores de velocidad y de generacion de potencia electrica fueron seleccionados para ser sustituidos por controladores difusos.

  18. Magnetic properties of Sm-based filled skutterudite phosphides

    Energy Technology Data Exchange (ETDEWEB)

    Giri, R.; Sekine, C.; Shimaya, Y.; Shirotani, I.; Matsuhira, K.; Doi, Y.; Hinatsu, Y.; Yokoyama, M.; Amitsuka, H

    2003-05-01

    Filled skutterudites SmFe{sub 4}P{sub 12} and SmOs{sub 4}P{sub 12} have been prepared at high temperature and high pressure. The temperature dependence of electrical resistivity in both compounds shows metallic behavior. The magnetic susceptibility and specific heat measurements indicate that SmFe{sub 4}P{sub 12} shows a ferromagnetic ordering at 1.5 K, whereas SmOs{sub 4}P{sub 12} is an antiferromagnet with a T{sub N} of 4.6 K.

  19. Arterial injury promotes medial chondrogenesis in Sm22 knockout mice.

    Science.gov (United States)

    Shen, Jianbin; Yang, Maozhou; Jiang, Hong; Ju, Donghong; Zheng, Jian-Pu; Xu, Zhonghui; Liao, Tang-Dong; Li, Li

    2011-04-01

    Expression of SM22 (also known as SM22alpha and transgelin), a vascular smooth muscle cells (VSMCs) marker, is down-regulated in arterial diseases involving medial osteochondrogenesis. We investigated the effect of SM22 deficiency in a mouse artery injury model to determine the role of SM22 in arterial chondrogenesis. Sm22 knockout (Sm22(-/-)) mice developed prominent medial chondrogenesis 2 weeks after carotid denudation as evidenced by the enhanced expression of chondrogenic markers including type II collagen, aggrecan, osteopontin, bone morphogenetic protein 2, and SRY-box containing gene 9 (SOX9). This was concomitant with suppression of VSMC key transcription factor myocardin and of VSMC markers such as SM α-actin and myosin heavy chain. The conversion tendency from myogenesis to chondrogenesis was also observed in primary Sm22(-/-) VSMCs and in a VSMC line after Sm22 knockdown: SM22 deficiency altered VSMC morphology with compromised stress fibre formation and increased actin dynamics. Meanwhile, the expression level of Sox9 mRNA was up-regulated while the mRNA levels of myocardin and VSMC markers were down-regulated, indicating a pro-chondrogenic transcriptional switch in SM22-deficient VSMCs. Furthermore, the increased expression of SOX9 was mediated by enhanced reactive oxygen species production and nuclear factor-κB pathway activation. These findings suggest that disruption of SM22 alters the actin cytoskeleton and promotes chondrogenic conversion of VSMCs.

  20. Características sociodemográficas de mujeres peruanas con virus papiloma humano detectado por PCR-RFLP

    Directory of Open Access Journals (Sweden)

    Yasser Sullcahuaman-Allende

    Full Text Available Con el objetivo de determinar las características sociodemográficas del virus de pacientes con papiloma humano (VPH referidas al Instituto Nacional de Enfermedades Neoplásicas (INEN durante los años 2012-2014, se realizó la detección del VPH en células cervicales por reacción en cadena de la polimerasa (PCR. En 465 muestras cervicales se detectaron 151 (32,5% casos de VPH positivas. Los genotipos más frecuentes fueron VPH-16 (23,8% y VPH-6 (11,9%. La presencia de VPH fue mayor en mujeres de 17 a 29 años (OR 2,64, IC 95%:1,14-6,13 y solteras (OR 2,31, IC 95%: 1,37-3,91, la presencia de genotipos de VPH de alto riesgo fue mayor en solteras (OR 2,19, IC 95%: 1,04-4,62. En conclusión, mujeres jóvenes y solteras presentaron mayor frecuencia de casos VPH-positivos a quienes se debe enfatizar la participación en programas de tamizaje con métodos moleculares y citológicos combinados, a fin de detectar oportunamente el riesgo de desarrollar cáncer de cuello uterino

  1. MODELADO DE LA CINÉTICA DE SECADO DE MANGO PRE-TRATADAS CON DESHIDRATACIÓN OSMÓTICA Y MICROONDAS

    Directory of Open Access Journals (Sweden)

    MARIBEL GARCÍA-PATERNINA

    Full Text Available La aplicación de tecnologías complementarias como la deshidratación osmótica y microondas como pre-tratamientos al secado convencional contribuye al desarrollo de nuevos productos y favorece la disminución de los cambios físico-químicos y organolépticos en el mango. El objetivo del trabajo fue evaluar el efecto de la deshidratación osmótica con una solución a 65°Brix de 37 a 40°C por 60 min, tratamiento con microondas a 560 W por 7 min y combinado como pre-tratamientos al secado de hojuelas de mango a 70°C en una estufa tipo bandeja y al sol. Las muestras de mango con 11 a 14°Brix y humedad del 80% fueron dimensionadas a 1x1x0,4 cm. La pérdida de peso y el tiempo de secado en los pre-tratados presentaron diferencias significativas (p0,99 se ajustó para el secado sin pre-tratamiento y el modelo de Vermet et al. (R²>0,99 para los pre-tratados. La De ff para microondas y secado en estufa fue mayor. Las hojuelas de mango pre-tratadas con deshidratación osmótica fueron las que mejor conservaron la apariencia de las hojuelas de mango

  2. Calidad de melón cantaloupe ( Cucumis melo cubierto con una película comestible de alginato - hpmc - parafina

    Directory of Open Access Journals (Sweden)

    Ma Concepción Reyes-Avalos

    2017-01-01

    Full Text Available Introducción : El melón es un fruto que tiene un corto periodo de almacenamiento. Una alternativa para extender este periodo es el uso de películas comestibles. En el presente estudio se evaluó el efecto de la aplicación de una película comestible de alginato de sodio - hidroxipropilmetilcelulosa - parafina (ALG - HPMC - PAR, sobre la calidad de melón Cantaloupe durante dos tipos de almacenamiento. Método : Frutos de melón Cantaloupe se cubrieron con una película comestible de alginato - hidroxipropilmetil celulosa - parafina (ALG - HPMC - PAR, y no cubiertos (CONTROL. Los melones se almacenaron por 21 días a 5ºC y 95% de humedad relativa (Hr. Cada siete días, los frutos se sometieron a análisis de índice de daños por frío, pérdida de peso, textura, y concentración de CO 2 y etileno d e la atmósfera interna del fruto. Además, para simular manejo comercial, al término de cada periodo de siete días en refrigeración, una muestra de melones era extraída del frigorífico y expuesta a condiciones ambientales de temperatura y humedad relativa ( 25ºC y 21 - 25% respectivamente durante tres días (almacenamiento combinado, y medidos los parámetros anteriormente mencionados. Resultados : La aplicación de la película comestible provocó que los frutos cubiertos tuvieran una mayor concentración de CO 2 y menor concentración de etileno en la atmósfera interna del fruto, contribuyendo a que los melones cubiertos mantuvieron su calidad por un mayor tiempo de almacenamiento, manteniéndose más firmes, con menor pérdida de peso y sufrir menor índice de daños por frío con respecto los frutos control. Discusión : Los resultados demuestran la factibilidad de la aplicación de películas comestibles para mantener la calidad del melón Cantaloupe almacenado en refrigeración y en almacenamiento combinado.

  3. Assessment of microseeds biodegradability of Sm and Sm:Ba splenic implants in rabbits

    International Nuclear Information System (INIS)

    Siqueira, Savio Lana; Barroso, Thiago Vinicius Villar; Campos, Tarcisio P.R.

    2009-01-01

    The radioactive interstitial implants have applications in controlling neoplasm in several regions of the human body. Currently the permanent brachytherapy seeds implanted in the spleen and other organs are made of I-125 seeds. After the total emission of radiation, the metal encapsulated seed remains inert in the implanted area. Seeds of bioactive ceramics have been prepared with Sm-152 incorporation to be activated in Sm-153. This study aimed to develop surgical technique for implanting biodegradable micro-seeds in the spleen of the rabbit. Three micro-seeds were introduced by hypodermic needle in the spleen in eight rabbits by median laparotomy. Subsequently, there were clinical and functional reactions of the animal to the implanted foreign body. The other objective was to perform the animal monitoring by radiography, produced in time sequence, and pathological studies of a fragment of the spleens of rabbits. The results show the effectiveness of surgery, the identification of the implanted material by radiography in vivo, and the biocompatibility of micro-seeds most of Sm and Sm:Ba. These seeds of reduced volume, 0.3x 1.6 mm, could be monitored for radiological studies in 2 periods: early and later implant. On the later studies, radiography was taken at 60d post-implant. Biopsies were taken and radiographs of the samples were also performed for evidencing the degradation state of the seeds. The results of the two groups of four rabbits are presented. They show partial degradation of the seed verified by radiographic contrast which is related to the atomic number of the elements and mass density in the seed. The biopsy showed that the ceramic is clearly absorbed by the spleen tissue and form tissue-implant interface. The histological slides showed an inflammatory reaction with presence of fibrosis of the giant cell foreign body. In conclusion, the radiograph shows a suitable noninvasive technique for monitoring the degradation of micro-seed ceramics in vivo

  4. Assessment of microseeds biodegradability of Sm and Sm:Ba splenic implants in rabbits

    Energy Technology Data Exchange (ETDEWEB)

    Siqueira, Savio Lana; Barroso, Thiago Vinicius Villar [Faculdade de Ciencias Medicas de Minas Gerais, Belo Horizonte, MG (Brazil). Dept. de Anatomia; Campos, Tarcisio P.R., E-mail: campos@nuclear.ufmg.b [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Programa de Ciencias e Tecnicas Nucleares

    2009-07-01

    The radioactive interstitial implants have applications in controlling neoplasm in several regions of the human body. Currently the permanent brachytherapy seeds implanted in the spleen and other organs are made of I-125 seeds. After the total emission of radiation, the metal encapsulated seed remains inert in the implanted area. Seeds of bioactive ceramics have been prepared with Sm-152 incorporation to be activated in Sm-153. This study aimed to develop surgical technique for implanting biodegradable micro-seeds in the spleen of the rabbit. Three micro-seeds were introduced by hypodermic needle in the spleen in eight rabbits by median laparotomy. Subsequently, there were clinical and functional reactions of the animal to the implanted foreign body. The other objective was to perform the animal monitoring by radiography, produced in time sequence, and pathological studies of a fragment of the spleens of rabbits. The results show the effectiveness of surgery, the identification of the implanted material by radiography in vivo, and the biocompatibility of micro-seeds most of Sm and Sm:Ba. These seeds of reduced volume, 0.3x 1.6 mm, could be monitored for radiological studies in 2 periods: early and later implant. On the later studies, radiography was taken at 60d post-implant. Biopsies were taken and radiographs of the samples were also performed for evidencing the degradation state of the seeds. The results of the two groups of four rabbits are presented. They show partial degradation of the seed verified by radiographic contrast which is related to the atomic number of the elements and mass density in the seed. The biopsy showed that the ceramic is clearly absorbed by the spleen tissue and form tissue-implant interface. The histological slides showed an inflammatory reaction with presence of fibrosis of the giant cell foreign body. In conclusion, the radiograph shows a suitable noninvasive technique for monitoring the degradation of micro-seed ceramics in vivo

  5. CRECIMIENTO DE Cedrela odorata L. BIOFERTILIZADA CON Rhizophagus intraradices y Azospirillum brasilense EN VIVERO

    Directory of Open Access Journals (Sweden)

    Juan F. Aguirre-Medina

    2014-01-01

    Full Text Available Cedrela odorata L. es una especie que se distingue por la calidad de su madera. El cedro esta - blecido en campo debe adaptarse a cambios en disponibilidad de recursos; la sobrevivivencia es mayor cuando el sistema radical se asocia con microorganismos que mejoran la nutrición y crecimiento. El objetivo del presente trabajo fue evaluar el efecto de Rhizophagus intraradi - ces y Azospirillum brasilense sobre el crecimiento de C. odorata y la capacidad de absorción de nitrógeno (N y fósforo (P. Las semillas de cedro se sembraron en macetas de acuerdo con los siguientes trata - mientos: testigo, fertilización 15 N -15 P -15 K , R. intraradices , A. brasilense , R. intraradices + A. brasilense , y R. intraradices + A. brasilense + fertilización 15 N -15 P -15 K . Las variables morfológicas y fisiológicas de rendimiento y la colonización radical se registraron cada 28 días, y los contenidos de N y P, al final del experimento (140 días. En general, R. intraradices promovió mayor crecimiento vegetal ( P ≤ 0.05 de los componentes morfológicos y fisiológicos del rendimiento. La altura máxima (97 cm se registró en las plantas con R. intraradices + A. brasilense + fertilización 15 N -15 P -15 K , representando 40 % más altura que el testigo. El N y P incrementaron con la inoculación de los microorganismos solos y combinados.

  6. Marcadores inflamatórios e anticorpos anti-chlamydia em pacientes com síndrome metabólica Marcadores inflamatorios y anticuerpos anti-chlamydia en pacientes con síndrome metabólico Inflammatory markers and antichlamydial antibodies in patients with metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Rosecler Riethmuller Franco

    2011-02-01

    ão mostraram diferença significativa em pacientes com SM, com e sem eventos.FUNDAMENTO: El síndrome metabólico está asociado al aumento de riesgo de eventos cardiovasculares. Marcadores inflamatorios y anticuerpos anti-Chlamydia han sido relacionados al desarrollo y a la progresión de la aterosclerosis y de los eventos cardiovasculares. OBJETIVO: Evaluar los marcadores inflamatorios interleucina-6 (IL-6 y factor de necrosis tumoral-alfa (TNF-α y los anticuerpos anti-Chlamydia pneumoniae en pacientes con síndrome metabólico (SM, con y sin eventos cardiovasculares. MÉTODOS: Estudio transversal constituido por 147 individuos. De estos, 100 (68% con SM y sin eventos cardiovasculares; y 47 (32% con SM y con eventos cardiovasculares. De los individuos que habían sufrido eventos cardiovasculares, 13 (6,11% presentan infarto agudo de miocardio (IAM, y diez (4,7%, accidente cerebro vascular (ACV. El diagnóstico del SM fue determinado por los criterios del NCEP-ATPIII. RESULTADOS: La media de edad de los sujetos con eventos cardiovasculares fue de 61,26 ± 8,5 y de 59,32 ± 9,9 en los individuos sin esos eventos (p=0,279, habiendo predominio del sexo femenino. El grupo con SM y sin evento presentó mayor peso, altura, IMC y circunferencia abdominal. Para los individuos con eventos cardiovasculares (p=0,001, los marcadores inflamatorios IL-6 y TNF-α y la enfermedad vascular periférica fueron significativamente mayores. Se obtuvieron niveles elevados de anticuerpos IgG para Chlamydia pneumoniae en el grupo SM, sin eventos y de IgA en el grupo con eventos cuando fueron comparados los dos grupos. Con relación al IAM y al ACV, los anticuerpos anti-Chlamydia pneumoniae no demostraron significación estadística, comparados al grupo sin eventos cardiovasculares. Asociación fue observada con el uso de estatinas, hipoglicemiantes orales, inyectables y antiinflamatorios no esteroides en el grupo con esos eventos. CONCLUSIÓN: Marcadores inflamatorios se encuentran

  7. Degeneracy lifting due to thermal fluctuations around the frustration point between anticlinic antiferroelectric SmC(A)* and synclinic ferroelectric SmC*.

    Science.gov (United States)

    Sandhya, K L; Chandani, A D L; Fukuda, Atsuo; Vij, Jagdish K; Emelyanenko, A V; Ishikawa, Ken

    2013-01-01

    In the binary mixture phase diagram of MC881 and MC452, the borderline between anticlinic antiferroelectric SmC(A)(*) and synclinic ferroelectric SmC(*) becomes apparently parallel to the temperature ordinate axis at the critical concentration r(c). The free energy difference between SmC(A)(*) and SmC^{*} is extremely small in a wide temperature range near r(c). In such circumstances, by observing Bragg reflection spectra due to the director helical structure and electric-field-induced birefringence, we have observed the continuous change from SmC(A)(*) to SmC(*) for r/~r(c). These intriguing phenomena have been explained, successfully at least in the high-temperature region, by a thermal equilibrium between the synclinic and anticlinic orderings and the resulting Boltzmann distribution for the ratio between them; the thermal equilibrium is considered to be attained in a nonuniform defect-assisted way through solitary waves moving around dynamically. We have also discussed qualitatively an important role played by the effective long-range interlayer interactions in the low-temperature region.

  8. checkCIF/PLATON report Datablock: Sm

    Indian Academy of Sciences (India)

    Moiety formula C59 H45 N2 O6 Sm. Sm (C14 H12 N2) ... 4.0 Ratio. PLAT234_ALERT_4_C Large Hirshfeld Difference O4 -- C24 .. 0.16 Ang. ... outliers and unusual parameters, but every test has its limitations and alerts that are not important.

  9. Nanocrystallization in Cu-Zr-Al-Sm Bulk Metallic Glasses

    Science.gov (United States)

    Sikan, Fatih; Yasar, Bengisu; Kalay, Ilkay

    2018-04-01

    The effect of rare-earth element (Sm) microalloying on the thermal stability and crystallization kinetics of melt-spun ribbons and suction-cast rods of Zr48Cu38.4Al9.6Sm4 alloy were investigated using differential scanning calorimetry (DSC), X-ray diffraction (XRD), transmission electron microscopy (TEM), and atom probe tomography (APT). The XRD results of constant heating rate annealing indicated that amorphous Zr48Cu38.4Al9.6Sm4 melt-spun ribbons devitrifies into Cu2Sm at 673 K (400 °C). The sequence continues with the precipitation of Cu10Zr7 and then these two phases coexist. XRD and TEM studies on 1 mm diameter as suction-cast rods indicated the precipitation of 30-nm-mean size Cu2Sm crystals during solidification. TEM investigation of the isothermal crystallization sequence of melt-spun ribbons and 1-mm-diameter suction-cast rods revealed the precipitation of Cu2Sm nanocrystals at the onset of crystallization and the restriction of the growth of these nanocrystals up to 10 nm diameter with further annealing. APT analysis of 1-mm-diameter suction-cast rods showed that the limited growth of Cu2Sm nanocrystals is due to sluggish diffusion of Sm and Al-Zr pile up at the interface.

  10. Gasification integrated to combined cycles; Gasificacion integrada a ciclos combinados

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez M, Manuel F; Alcaraz C, Agustin M [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2001-07-01

    de metales. Finalmente, en los nuevos esquemas de refinacion del petroleo se preve utilizar la coquizacion para aprovechar mejor el ondo de barril. El residuo producto de este proceso, conocido como coque de refineria, tiene un bajo valor comercial, un poder calorifico elevado y un alto contenido de azufre y metales. La gasificacion ha sido desarrollada en las ultimas dos decadas, en los paises altamente industrializados, como una alternativa para la generacion eficiente y limpia de electricidad a partir de combustibles sucios, asi como para la obtencion de ciertos combustibles en lugares donde no se tiene acceso al petroleo, pero si al carbon. Esta tecnologia cumple los reglamentos mas estrictos del mundo en lo que a emisiones contaminantes se refiere y es la unica solucion, junto a los lechos fluidizados, para los problemas que presentan algunos combustibles que son dificiles de quemar con tecnologias convencionales, como el carbon mineral, el coque de petroleo e incluso los residuos liquidos de la refinacion. Con base en los anterior, es posible pensar en la integracion de esta tecnologia a una planta de ciclo combinado para la generacion de electricidad o a una refineria generando vapor, energia electrica, hidrogeno y otros insumos a un costo competitivo, de manera tal que se resuelven los problemas de manejo y almacenamiento de los residuos; por otro lado se maximiza el aprovechamiento de los recursos energeticos primarios en el pais.

  11. Simulación con Monte Carlo para dosimetría de 153Samario-HM en un modelo anatómico geométrico de rodilla humana

    Directory of Open Access Journals (Sweden)

    Hardy Pérez Alberto Ernesto

    2010-01-01

    Full Text Available El 153Sm-hm es una nueva opción para realizar sinovectomía por radiación, que actualmente se encuentra en valoración. Este trabajo tiene como objetivo calcular la dosis absorbida en tejidos articulares proporcionada por la administración de 153Sm-hm intraarticular, utilizando la simulación de Monte Carlo, en una propuesta de un modelo simplificado anatómico geométrico de la articulación de la rodilla. Esto con el propósito de aportar datos que apoyen la administración segura y eficaz del radiofármaco en estudio a pacientes con enfermedad reumática de la articulación de la rodilla. Se concluye que la actividad administrada de 153Sm-hm por vía intra-articular es de 370 MBq para conseguir una dosis absorbida en membrana sinovial de 110 Gy, considerada como la dosis de ablación de la mencionada membrana.

  12. Gamma ray irradiation characteristics of SM fibers

    International Nuclear Information System (INIS)

    Ito, Ryuichi; Okano, Hiroaki; Hashiba, Keichi; Nakai, Hisanori

    1987-01-01

    1.3 μm range single mode (SM) optical fibers have been used for wide application of mainly long distance communication. At present, in order to realize the larger capacity and longer distance between relay points, the development of 1.5 μm range SM fibers of low dispersion and small loss has been actively promoted. As for the radiation withstanding property of SM fibers, report is scarce. The authors reported on the gamma ray irradiation characteristics of 1.3 μm range SM fibers, but since 1.5 μm range SM fibers are designed with the different structure from that of 1.3 μm fibers, it is necessary to evaluate from new viewpoint. In this report, mainly on the structure having triangular distribution, the effect that the manufacturing condition and the structural defects of glass exert on the gamma ray irradiation characteristics is described. The specimens were mainly dispersion shift type fibers (DSF), and for comparison, single window, double window and 1.3 μm SM fibers were examined. Co-60 gamma ray was irradiated, and the optical loss and electron spin resonance were measured. By low temperature and low speed drawing, the good result in the optical loss was obtained. The presence of oxygen at the time of sintering materials had no effect. The dependence of the ESR on the drawing condition was not very remarkable. (Kako, I.)

  13. Technological tendencies for the development and implementation of fault tolerant active controls in combined cycle power plants; Tendencias tecnologicas para el desarrollo e implantacion de controles activos tolerantes a fallas en centrales de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez P, Marino; Verde R, Cristina [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2006-07-01

    This document proposes a methodology that reunites support tools for the operator of a Combined Cycle Generating Power Station allowing him to identify and to classify gas turbine faults, it also reunites some tools for the generation of action advices in the decision making on the operation maneuvers necessary to counteract the effects caused by faults. We are talking about a system implemented in a power station with the reconfiguration of processes and fault arrangement capacities. For this purpose, the line of exhibition delimits first the existing knowledge on automatic control and operations supervision systems in a CCPP and immediately emphasizes the cracks of the system to let pass to the fault tolerant active control system that will detect faults of the gas and steam turbo-generators of a Combined Cycle Generating Power Plant. [Spanish] El presente documento propone una metodologia que reuna herramientas de ayuda al operador de una Central Generadora de Electricidad de Ciclo Combinado para permitirle la identificacion y clasificacion de fallas en las turbinas de gas, asi como herramientas para la generacion de consejos de accion en la toma de decisiones sobre las maniobras de operacion necesarias para contrarrestar los efectos provocados por fallas. Se trata principalmente de un sistema implantado en una central con las capacidades de re-configuracion de procesos y acomodo de fallas. Para esto, la linea de exposicion delimita primero el conocimiento existente sobre sistemas automaticos de control y supervision de operacion en una CGCC y resalta enseguida las grietas del sistema para darle paso al sistema de control activo tolerante a fallas que detectara fallas de los turbogeneradores de gas y vapor de una Central Generadora de Electricidad de Ciclo Combinado.

  14. 178. Linfoma cardíaco. Una neoplasia infrecuente

    Directory of Open Access Journals (Sweden)

    E. Sandoval

    2010-01-01

    Conclusiones: Los linfomas cardíacos son de alto grado de agresividad. La localización principal es la aurícula derecha, con clínica inespecífica y variable. No existe claro consenso sobre el tratamiento de elección, pero parece haber mayor supervivencia con tratamiento combinado con quimioterapia con antraciclínicos y radioterapia.

  15. La brecha digital de género en España y Europa: medición con indicadores compuestos

    Directory of Open Access Journals (Sweden)

    Cecilia Castaño

    2011-01-01

    Full Text Available En esta nota de investigación se presenta un sistema de indicadores compuestos diseñado para describir la brecha digital de género. Esta herramienta, denominada Sistema de Indicadores de Género y TIC (SIGTIC, entendemos que supone un avance en la medición y análisis de la situación diferenciada de mujeres y hombres en la Sociedad de la Información. Su aplicación permite: a hacer comparaciones inter-género, determinadas por el grado de e-igualdad; b realizar análisis intra-género, en función del grado de e-inclusión de cada sexo; y c contextualizar los resultados obtenidos con los correspondientes a 31 países europeos. Además, esa perspectiva analítica transnacional se concreta en unos rankings de países y su clasificación en cinco categorías en función del nivel de uso de TIC, combinado con el grado de igualdad de género existente.

  16. Exercício físico aeróbio, resistido e combinado: efeitos na pressão arterial em indivíduos hipertensos

    Directory of Open Access Journals (Sweden)

    Julia Spanhol da Silva

    2014-07-01

    Full Text Available Objetivo: analisar possíveis efeitos na pressão arterial de três sujeitos hipertensos, a partir da aplicação de três tipos de exercícios: aeróbio, resistido e combinado. Método: o estudo de caso utilizou, como instrumento, equipamento manual de verificação de pressão arterial, monitor de frequência cardíaca Polar, ficha de anotações da pressão arterial e frequência cardíaca. Os sujeitos analisados realizaram as atividades em academia do município de Passo Fundo-RS. Resultados e considerações finais: na PAS e na PAD, o exercício que obteve efeito hipotensor foi o resistido e na FC, o treinamento que obteve melhor resposta hipotensora foi também o treino resistido, seguido do treinamento combinado, em que o treinamento aeróbio apenas diminuiu seus valores de desvio padrão. Para tanto, conclui-se que, para estes indivíduos participantes do estudo, o melhor treinamento e os melhores resultados foram alcançados pelo treinamento resistido.

  17. Terapia de bioestimulación con plasma rico en plaquetas para el envejecimiento cutáneo Bioestimulation technique with rich plasma in platelets for skin aging

    OpenAIRE

    HM Escobar

    2012-01-01

    La bioestimulación con plasma rico en plaquetas es una técnica ambulatoria para la prevención y manejo del envejecimiento cutáneo, se basa en la fisiología de la piel y funciona muy bien sola o dentro de un plan terapéutico combinado. El derivado de sangre autóloga estimula la producción de colágeno, elastina y tejido epidérmico, lo que se traduce en piel más tersa, luminosa y de mejor calidad. Son mínimos los riesgos de formación de hematomas, infección, transmisión de enfermedades o reaccio...

  18. Structural and Magnetic Properties of Sm Implanted GaN

    International Nuclear Information System (INIS)

    Li-Juan, Jiang; Xiao-Liang, Wang; Hong-Ling, Xiao; Zhan-Guo, Wang; Chun, Feng; Ming-Lan, Zhang; Jian, Tang

    2009-01-01

    The structural and magnetic properties of Sm ion-implanted GaN with different Sm concentrations are investigated. XRD results do not show any peaks associated with second phase formation. Magnetic investigations performed by superconducting quantum interference device reveal ferromagnetic behavior with an ordering temperature above room temperature in all the implanted samples, while the effective magnetic moment per Sm obtained from saturation magnetization gives a much higher value than the atomic moment of Sm. These results could be explained by the phenomenological model proposed by Dhar et al. [Phys. Rev. Lett. 94(2005)037205, Phys. Rev. B 72(2005)245203] in terms of a long-range spin polarization of the GaN matrix by the Sm atoms. (condensed matter: electronicstructure, electrical, magnetic, and opticalproperties)

  19. Caracterización experimental y modelización de una enfriadora de absorción de simple/doble efecto de h2o-libr con accionamiento a dos temperaturas para climatización de edificios

    OpenAIRE

    Figueredo, Gustavo Raúl

    2012-01-01

    Durante la última década se produjo un enorme crecimiento de la implantación de la climatización de edificios, motivada por el aumento de los requerimientos de confort y de productividad de la población, entre otras causas. Los equipos de climatización más difundidos se accionan mediante energía eléctrica, lo que combinado con la gran simultaneidad de la demanda de climatización y su elevado consumo, provocan puntas de demanda de electricidad que sobrecargan las redes y frecuentement...

  20. Emission properties of Sm(III) complex having ten-coordination structure

    International Nuclear Information System (INIS)

    Hasegawa, Yasuchika; Tsuruoka, Shin-ichi; Yoshida, Takahiko; Kawai, Hideki; Kawai, Tsuyoshi

    2008-01-01

    Sammarium(III) complex having ten-coordination structure, bis-(1,10-phenanthroline)tris-(hexafluoroacetylacetonato)samarium(III) (Sm(hfa) 3 (phen) 2 ) was prepared by chelation of tris-(hexafluoroacetylacetonato) samarium(III) (Sm(hfa) 3 (H 2 O) 2 ) with 1,10-phenantroline (phen). The characteristic ten-coordination structure of Sm(hfa) 3 (phen) 2 was determined by 1 H NMR and elemental analyses. Strong deep-red emission (λ max =643 nm) and narrow emission band (FWHM=5 nm) of Sm(hfa) 3 (phen) 2 originated from electronic allowed transition from characteristics ten coordinate structure. The emission quantum yields Sm(hfa) 3 (phen) 2 excited at absorption bands of ligands and Sm(III) ion were found to be 0.36 and 1.4%, respectively

  1. EFEITOS DO TREINAMENTO COMBINADO SOBRE A FORÇA, RESISTÊNCIA E POTÊNCIA AERÓBICA EM IDOSAS

    OpenAIRE

    Guedes, Janesca Mansur; Bortoluzzi, Marília Guedes; Matte, Luciana Pauline; Andrade, Ciele Maria de; Zulpo, Nilciane Coppatti; Sebben, Vanessa; Tourinho Filho, Hugo

    2016-01-01

    RESUMO Introdução: O envelhecimento traz várias modificações, entre as quais o declínio progressivo das funções fisiológicas do organismo. Tanto o treino de força quanto um programa de resistência aeróbica são importantes para evitar o declínio funcional associado à idade. Objetivo: Avaliar os efeitos de um programa de treinamento combinado de força e resistência aeróbica sobre a força de preensão manual, a massa muscular, a resistência e potência aeróbica de idosas. Métodos: Trinta e cinc...

  2. Phase formation and crystallization behavior of melt spun Sm-Fe-based alloys

    International Nuclear Information System (INIS)

    Shield, J.E.

    1999-01-01

    The phase formation and microstructures of Sm-Fe alloys have been investigated at Sm levels of 11 and 17 atomic percent and with alloying additions of Ti and C. At lower Sm content, virtually phase pure SmFe 7 formed, while higher Sm content resulted in the formation of SmFe 7 , SmFe 2 and amorphous phases. The addition of Ti and C resulted in greater stability and a larger volume fraction of the amorphous phase. The binary Sm-Fe alloys at both Sm levels had tremendously variable microstructures, with large discrepancies in grain size and phase distribution from region to region. The addition of Ti and C tended to result in a more homogeneous microstructure, as well as a refinement in the microstructural scale. (orig.)

  3. Edad, escolarización y tareas de Fluencia Verbal para el screening de pacientes con Enfermedad de Alzheimer

    Directory of Open Access Journals (Sweden)

    Adriana Goñi Sarriés

    2015-10-01

    Full Text Available Introducción: Las pruebas de Fluencia Verbal (FV Semántica (FVS y Fonológica (FVF son muy empleadas en la práctica clínica. Disponer de diferentes pruebas alternativas que además tengan en cuenta el efecto de variables sociodemográficas mejorarían su uso como tests de cribado, permitiendo diferenciar a personas con y sin Enfermedad de Alzheimer (EA. Objetivos. Comparar la capacidad discriminativa de las tareas de FVS "cosas en una casa" y "alimentos" frente a la tarea "animales" entre pacientes con EA (n = 50 y sujetos sanos (n = 50; comparar el uso de los fonemas "P"-"M"-"R" como tarea alternativa y/o paralela a los fonemas "F"-"A"-"S"; y valorar el uso combinado de ambos tipos de tareas junto con el de variables sociodemográficas para la discriminación de pacientes con EA y sujetos sanos. Resultados: Tanto la categoría semántica como fonológica muestran resultados semejantes, una alta correlación, mantienen la validez de criterio y permiten su utilización de forma paralela. El modelo de predicción que logra discriminar correctamente al 91% de los sujetos evaluados es el que incluye las tareas "cosas en una casa", los fonemas "A" -"S" y las variables edad y años de escolarización. Conclusiones: La utilización paralela de pruebas de FVS y FVF, junto con variables sociodemográficas mejora la capacidad discriminativa de las pruebas de FV.

  4. FRECUENCIA DE HIPERTENSIÓN ARTERIAL SISTÉMICA EN PERROS CON SOBREPESO U OBESIDAD Y SUS PATOLOGÍAS ASOCIADAS

    OpenAIRE

    Pérez Sánchez, Alicia Pamela

    2014-01-01

    La obesidad es una enfermedad relacionada con diferentes alteraciones metabólicas como la dislipidemia (hipercolesterolemia e hipertrigliceridemia), resistencia a la insulina e hipertensión arterial sistémica (HTA). El humano con obesidad y la presencia de dos de estas alteraciones, es denominado como un caso de síndrome metabólico (SM) en el que cobra interés el mecanismo fisiopatológico del proceso obesidad-hipertensión. En medicina veterinaria estas alteraciones metabólicas ...

  5. ¿Psicoterapia, farmacoterapia o tratamiento combinado? Influencia de diferentes variables clínicas en la elección del tratamiento

    OpenAIRE

    Vanessa Ferreres; Josep Pena-Garijo; María Ballester Gil de Pareja; Silvia Edo; Iria Sanjurjo; Luisa Ysern

    2012-01-01

    Introducción: Se pretenden investigar las principales variables que influyen en la elección de las diferentes intervenciones terapéuticas en una Unidad de Salud Mental Pública Método: Estudio descriptivo sobre las historias clínicas de aquellos pacientes que iniciaron tratamiento durante el año 2008 en una USM de Castellón (N=413). Resultados: El tratamiento psicofarmacológico fue el más frecuentemente utilizado. La psicoterapia sola y el tratamiento combinado se utilizaron más frecuentemente...

  6. Composites con refuerzos naturales para aplicaciones en automoción y construcción

    Directory of Open Access Journals (Sweden)

    Gurmendi, U.

    2010-12-01

    Full Text Available The assumption of the future exhaustion of the crude reserves world-wide and the increasing environmental concerns is leading to consider, more and more insistently, the use of regenerable raw materials for the design and development of new vehicle components. The main objective of this project consists on the evaluation of pine powder and corn powder as reinforcement for different PP resins. A compatilibization study has been defined and set-up in order to combine these two reinforcements with three different resins based on PP. A final material selection has been carried out to produce an automotive prototype part.

    La evidencia del agotamiento de las reservas de crudo a nivel mundial junto con el cumplimiento de exigencias medioambientales, cada vez más estrictas, llevan a considerar, cada vez en mayor escala, la necesidad de la utilización de materias primas renovables para el diseño y fabricación de nuevos componentes del vehículo. El objetivo principal de este trabajo se centra en la evaluación de materiales, como la harina de pino y la harina de maíz, para ser utilizados como elementos de refuerzo y ser combinados con diferentes matrices termoplásticas de polipropileno. La definición y puesta a punto de un proceso de compatibilización ha hecho posible la formulación de estas harinas con tres matrices comerciales de base PP. Una posterior selección de material se ha llevada a cabo con el fin de determinar los materiales para la fabricación de una pieza prototipo.

  7. High coercivity Sm-Co thin films from elemental Sm/Co multilayer deposition and their microstructural aspects

    Energy Technology Data Exchange (ETDEWEB)

    Krishnan, M. [Surface Engineering Division, CSIR-National Aerospace Laboratories, Bangalore 560 017 (India); Department of Physics, National Institute of Technology Calicut, Calicut 673601 (India); Predeep, P. [Department of Physics, National Institute of Technology Calicut, Calicut 673601 (India); Sridhara Rao, D.V. [Defence Metallurgical Research Laboratories, Hyderabad 500058 (India); Prajapat, C.L.; Singh, M.R. [Technical Physics Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Barshilia, Harish C. [Surface Engineering Division, CSIR-National Aerospace Laboratories, Bangalore 560 017 (India); Chowdhury, P., E-mail: pchowdhury@nal.res.in [Surface Engineering Division, CSIR-National Aerospace Laboratories, Bangalore 560 017 (India)

    2017-05-15

    Hard magnetic thin films with high coercivity were fabricated by magnetron sputtering on MgO(100) and quartz substrates. The films were grown by depositing sequentially Sm and Co layers at an elevated substrate temperature of 500 °C. Subsequent post-annealing was carried out at various temperatures in range of 500–700 °C to form Sm-Co hard magnetic thin films. X-ray diffraction studies revealed the formation of randomly oriented SmCo{sub 5} crystallites on quartz substrate, whereas, a textured growth of Sm{sub 2}Co{sub 7} with strong (110) crystalline phases was observed on MgO substrate. Microstructural analyses were carried out using Transmission Electron Microscopy (TEM) for samples grown on MgO substrate at 650 °C and inferred the presence of high density planar defects along with large grain boundaries. Further microdiffraction studies confirmed the presence of SmCo{sub 3} as an impurity phase in the films. Magnetic hysteresis measurements indicate the square hysteresis behaviors with high coercivity value of 3.1 T and 2.7 T for 650 °C annealed samples on both MgO and quartz substrates, respectively. The origin of such high coercivity value was then correlated with pinning type of spin reversal mechanism as confirmed through the analyses of demagnetization curves. The magnetic force microscopy images for films on MgO substrate, annealed at 650 °C, revealed the presence of magnetic domains with size higher than 1 µm. The formed magnetic domains lacked well defined boundaries indicating an enhanced exchange coupling between the grain clusters. - Highlights: • Ewald technique in micromagnetic simulations with periodic boundary conditions. • Effect of micromagnetic parameters on hysteresis in exchange spring magnets. • Importance of the interface exchange coupling for hard-soft nanocomposites. • Geometry dependence of the optimal soft phase size in exchange spring magnets.

  8. Sm29, but not Sm22.6 retains its ability to induce a protective immune response in mice previously exposed to a Schistosoma mansoni infection.

    Directory of Open Access Journals (Sweden)

    Clarice Carvalho Alves

    2015-02-01

    Full Text Available BACKGROUND: A vaccine against schistosomiasis would have a great impact in disease elimination. Sm29 and Sm22.6 are two parasite tegument proteins which represent promising antigens to compose a vaccine. These antigens have been associated with resistance to infection and reinfection in individuals living in endemic area for the disease and induced partial protection when evaluated in immunization trials using naïve mice. METHODOLOGY/PRINCIPALS FINDINGS: In this study we evaluated rSm29 and rSm22.6 ability to induce protection in Balb/c mice that had been previously infected with S. mansoni and further treated with Praziquantel. Our results demonstrate that three doses of the vaccine containing rSm29 were necessary to elicit significant protection (26%-48%. Immunization of mice with rSm29 induced a significant production of IL-2, IFN-γ, IL-17, IL-4; significant production of specific antibodies; increased percentage of CD4+ central memory cells in comparison with infected and treated saline group and increased percentage of CD4+ effector memory cells in comparison with naïve Balb/c mice immunized with rSm29. On the other hand, although immunization with Sm22.6 induced a robust immune response, it failed to induce protection. CONCLUSION/SIGNIFICANCE: Our results demonstrate that rSm29 retains its ability to induce protection in previously infected animals, reinforcing its potential as a vaccine candidate.

  9. Efecto del entrenamiento combinado de pliometría y electroestimulación en salto vertical. (Effect of combined plyometric and electrostimulation training on vertical jump.

    Directory of Open Access Journals (Sweden)

    Elisa Benito Martínez

    2010-10-01

    Full Text Available Resumen En este estudio se han analizado los efectos del entrenamiento combinado de pliometría y electroestimulación en un entrenamiento de fuerza muscular de los miembros inferiores. El estudio incluyó tres grupos experimentales, que trabajaron ambos métodos en orden diferente y de forma simultánea, y uno de control. Participaron 78 atletas, 40 mujeres y 38 hombres, de disciplinas de velocidad (100 y 200 m lisos y 100 y 110 m vallas, con una edad de 17,94 ± 1,44 años y una masa de 58,53 ± 8,05 kg. El programa incluyó dos días / sem de entrenamiento pliométrico y dos sesiones utilizando un electroestimulador Megasonic 313-P4. Tras dos meses de entrenamiento, se midió con plataforma de contacto ORGANISER PSION 2 la altura de salto vertical y potencia del tren inferior en test de Abalakov y Drop Jump. Las mayores diferencias pre/post test (p Abstract This paper analyses the effects of combined electrostimulation and plyometric training on lower body strength training. The training programme was applied to three experimental groups and one control group. The experimental groups used both methods simultaneously but in different order. The participants were 78 sprinters (100m and 200m, and 100m and 110m hurdles, 38 male and 40 female. Their average age was 15,9 ± 1,4 years and their average weight was 58,53 ± 8,05kg. The training programme consisted in two days a week of plyometric training and two sessions with a Megasonic 313-P4 electrostimulation unit. After two months training, vertical jump height and lower body power were measured in Abalakov test and Drop Jump test with PSION ORGANISER II. The most significant pre- and post-test (p

  10. Hydrogen-induced amorphization of SmFe{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Kubis, M.; Handstein, A.; Gebel, B.; Gutfleisch, O.; Mueller, K.-H.; Schultz, L. [Institut fuer Festkoerper- und Werkstofforschung Dresden e.V. (Germany). Inst. fuer Metallische Werkstoffe

    2000-07-01

    The hydrogen absorption behavior of SmFe{sub 3} (PuNi{sub 3}-type structure) was observed in the range from 0.05 to 4 MPa by differential scanning calorimetry. The structural changes were observed by X-ray diffraction measurements. For pressures below 0.8 MPa two exothermic reactions were found which are attributed (i) to the interstitial absorption and (ii) to the disproportionation into SmH{sub 2} and {alpha}-Fe. For higher hydrogen pressures, the second exothermic peak occured at significantly lower temperatures and splitted into two peaks. The first one was identified as the exothermic signal of the hydrogen-induced amorphization of the SmFe{sub 3} hydride. The second peak is caused by the precipitation of SmH{sub 2} and {alpha}-Fe from the amorphous material. (orig.)

  11. Preferential removal of Sm by evaporation from Nd-Sm mixture and its application in direct burn-up determination of spent nuclear fuel

    International Nuclear Information System (INIS)

    Sajimol, R.; Bera, S.; Nalini, S.; Sivaraman, N.; Joseph, M.; Kumar, T.

    2016-01-01

    Rate of evaporation of Sm and Nd from their mixture was studied based on their ion intensities using thermal ionization mass spectrometry. Because of the comparatively larger evaporation rate of Sm, it was found possible to get the isotopic composition of Nd (fission product monitor) free from isobaric interference of Sm isotopes. The decrease in ion intensity of Sm was studied as a function of time and filament temperature. Based on this study, an easy and time effective method for the determination of burn-up of spent nuclear fuel was examined and the results are compared with that obtained by the conventional method. Typical burn-up value obtained for a pressurized heavy water reactor fuel dissolver solution using the direct method by preferential evaporation of Sm is: 0.84 at.%, whereas the one obtained by the use of conventional method is 0.82 at.%. In both the cases, Nd was employed as the fission product monitor. (author)

  12. Estudios de laboratorio para el control de Ceratitis capitata (Wiedmann (Diptera: Tephritidae (Mosca del Mediterráneo con Beauveria bassiana

    Directory of Open Access Journals (Sweden)

    Luis Porras

    2008-01-01

    Full Text Available Con el objetivo de seleccionar cepas promisorias de Beauveria bassiana para el control de Ceratitis capitata, se realizó, en condiciones de laboratorio, una serie de ensayos empleando la mosca adulta como estado vulnerable al parasitismo por el hongo entomopatógeno. Para la selección se utilizó una concentración de 5x109 CV.m-2 del hongo. Se determinó la CL90, la sobrevivencia media (SM, la compatibilidad con insecticidas, además de ensayos de producción con el hongo. Así como la compatibilidad de los insecticidas Mercaptotion 100% CE (Lupara® y Dimetoato 40% CE (Sistémico Icona con las cepas seleccionadas. Se cuantificó la viabilidad de los conidios en platos de Petri pos-tratamiento, a 50, 100 y 200% de la dosis comercial del insecticida. A partir de 7 cepas evaluadas (mortalidad 97-14% fueron seleccionadas la Bb 26, la Bb 259, la Bb 132, y la Bb 238. Los valores de CL90 estuvieron entre 1x109 y 3,8 x1011 CV.m-2 (Bb 238 y Bb 26, respectivamente. La SM de las cepas varió de 7-12 días (Bb 238 y Bb 26, respectivamente. La mayor producción fue de 7x109 UFC.mg-1 y 20,7 g.conidios.kg-1 de arroz (Bb 26. Todas las cepas fueron compatibles con Mercaptotion y la Bb 132 presentó la mayor compatibilidad con el Dimetoato. En conclusión, los ensayos en el laboratorio permitieron seleccionar cepas de B. bassiana con potencial para controlar C. capitata.

  13. High spin states in 143Sm

    International Nuclear Information System (INIS)

    Raut, R.; Ganguly, S.; Kshetri, R.; Banerjee, P.; Bhattacharya, S.; Dasmahapatra, B.; Mukherjee, A.; Mukherjee, G.; Sarkar, M. Saha; Goswami, A.; Gangopadhyay, G.; Mukhopadhyay, S.; Krishichayan,; Chakraborty, A.; Ghughre, S. S.; Bhattacharjee, T.; Basu, S. K.

    2006-01-01

    The high spin states of 143 Sm have been studied by in-beam γ-spectroscopy following the reaction 130 Te( 20 Ne,7n) 143 Sm at E lab =137 MeV, using a Clover detector array. More than 50 new gamma transitions have been placed above the previously known J π =23/2 - , 30 ms isomer at 2795 keV. The level scheme of 143 Sm has been extended up to 12 MeV and spin-parity assignments have been made to most of the newly proposed level. Theoretical calculation with the relativistic mean field approach using blocked BCS method, has been performed. A sequence of levels connected by M1 transitions have been observed at an excitation energy ∼8.6 MeV. The sequence appears to be a magnetic rotational band from systematics

  14. Chemical methods for Sm-Nd separation and its application in isotopic geological dating

    International Nuclear Information System (INIS)

    Guo Qifeng.

    1990-01-01

    Three chemical methods for Sm-Nd separation are mainly desribed: low chromatography of butamone-ammonium thiocyanate for hight concentration Sm and Nd separation, P 240 column chromatography for medium concentration Sm-Nd separation, and pressure ion exchange for low concentration Sm-Nd. The first Sm-Nd synchrone obtained in China with Sm-Nd methods is introduced and Sm-Nd isotopic geological dating in Early Archaean rocks in eastern Hebei has been determined

  15. Smáčivost povrchových úprav DPS

    OpenAIRE

    Minář, Jan

    2016-01-01

    Tato bakalářská práce se zabývá měřením smáčecích charakteristik pomocí metody smáčecích vah u vzorků různých povrchových úprav od firmy Gatema. Věnuje se vlivu izotermálního stárnutí a přetavovacích procesů na smáčecí charakteristiky povrchových úprav ENIG, bezolovnatý HAL a imerzní cín. U povrchové úpravy imerzním cínem je sledován vliv intermetalické vrstvy na celkovou smáčivost. Dále se zabývá smáčivostí vrstvy niklu, po odstripování zlata, u povrchové úpravy ENIG. This bachelor’s thes...

  16. VUV light induced valence degeneration in Sm over-layer on HOPG

    International Nuclear Information System (INIS)

    Kutluk, G; Nakatake, M; Arita, M; Namatame, H; Taniguchi, M; Ishitobi, Y; Sumida, H

    2013-01-01

    Systematic investigation of the influence of vacuum ultraviolet (VUV) irradiation on the valence degeneration in a Sm over-layer on a HOPG substrate was performed using in-situ photoemission spectroscopy (XPS, UPS, and ARPES) for the Sm coverage regime of 0.05-3.6 Å. This investigation confirmed that VUV irradiation-induced degeneration of divalent Sm exerts a more profound effect than Sm contamination during photoemission spectroscopy even under UHV. We found that the charge transfer occurs mainly from divalent Sm to the HOPG surface.

  17. Desempeño lector en niños con diagnóstico de TDAH (Trastorno de Déficit de Atención con Hiperactividad/ Reading performance in children with ADHD (Attention-Deficit/Hyperactivity Disorder

    Directory of Open Access Journals (Sweden)

    María Alexandra Cardona Tangarife

    2017-04-01

    Full Text Available Con el objetivo de determinar la relación entre la edad, el subtipo clínico, el carácter de la institución y las variables neuropsicológicas en pruebas de lectura en niños diagnosticados con Trastorno por Déficit de Atención Hiperactividad-TDAH (n= 36, inatento; n= 52 y un grupo control (n=88, se estudiaron 176 niños provenientes de escuelas públicas y privadas de la ciudad de Manizales-Caldas, con edades entre los 6 y 13 años. A estos niños se les evaluó desempeño lector, atención, habilidades construccionales, memoria, lenguaje y funciones ejecutivas, por medio de la Evaluación Neuropsicológica Infantil (ENI. Los resultados en el análisis por subgrupos (combinado, inatento y control evidencian diferencias significativas. El grupo control puntuó en general más alto que ambos subtipos de TDAH. En cuantoal tipo de institución, los niños que asisten a escuelas de carácter privado, arrojaron valores superiores en comparación a los niños que asisten a instituciones educativas de carácter oficial, pero esta diferencia disminuyó a medida que avanzó la escolaridad. En relación a las variables neuropsicológicas,se halló que las variables atencionales pueden predecir la velocidad de lectura.Se concluyó que las variables escolares, la edad y el subgrupo permiten diferenciar el desempeño lector. Los resultados se discutieron y compararon con nuevos trabajos sobre la misma línea.

  18. β-decay spectroscopy of neutron-rich 160,161,162Sm isotopes

    Directory of Open Access Journals (Sweden)

    Patel Z.

    2016-01-01

    Full Text Available Neutron-rich 160,161,162Sm isotopes have been populated at the RIBF, RIKEN via β first time. β-coincident γ rays were observed in all three isotopes including γ rays from the isomeric decay of 160Sm and 162Sm. The isomers in 160Sm and 162Sm have previously been observed but have been populated via β decay for the first time. The isomeric state in 162Sm is assigned a 4−v72+[ 633 ]⊗v12−[ 521 ]${4^ - }v{{7 \\over 2}^ + }\\left[ {633} \\right] \\otimes v{{1 \\over 2}^ - }\\left[ {521} \\right]$ configuration based on the decay pattern. The level schemes of 160Sm and 162Sm are presented. The ground states in the parent nuclei 160Pm and 162Pm are both assigned a 6−v72+[633]⊗π52−[532]${6^ - }v{{7 \\over 2}^ + }\\left[ {633} \\right] \\otimes \\pi {{5 \\over 2}^ - }\\left[ {532} \\right]$ configuration based on the population of states in the daughter nuclei. Blocked BCS calculations were performed to further investigate the spin-parities of the ground states in 160Pm, 161Pm, and 162Pm, and the isomeric state in 162Sm

  19. Higher-order scalar interactions and SM vacuum stability

    Energy Technology Data Exchange (ETDEWEB)

    Lalak, Zygmunt; Lewicki, Marek; Olszewski, Paweł [Institute of Theoretical Physics, Faculty of Physics, University of Warsawul. Hoża 69, Warsaw (Poland)

    2014-05-26

    Investigation of the structure of the Standard Model effective potential at very large field strengths opens a window towards new phenomena and can reveal properties of the UV completion of the SM. The map of the lifetimes of the vacua of the SM enhanced by nonrenormalizable scalar couplings has been compiled to show how new interactions modify stability of the electroweak vacuum. Whereas it is possible to stabilize the SM by adding Planck scale suppressed interactions and taking into account running of the new couplings, the generic effect is shortening the lifetime and hence further destabilisation of the SM electroweak vacuum. These findings have been illustrated with phase diagrams of modified SM-like models. It has been demonstrated that stabilisation can be achieved by lowering the suppression scale of higher order operators while picking up such combinations of new couplings, which do not deepen the new minima of the potential. Our results show the dependence of the lifetime of the electroweak minimum on the magnitude of the new couplings, including cases with very small couplings (which means very large effective suppression scale) and couplings vastly different in magnitude (which corresponds to two different suppression scales)

  20. Synthesis and magnetic properties of SmOOH crystals

    Energy Technology Data Exchange (ETDEWEB)

    Samata, Hiroaki, E-mail: samata@maritime.kobe-u.ac.jp [Graduate School of Maritime Sciences, Kobe University, Fukaeminami, Higashinada, Kobe, Hyogo 658-0022 (Japan); Hanioka, Masashi [Graduate School of Maritime Sciences, Kobe University, Fukaeminami, Higashinada, Kobe, Hyogo 658-0022 (Japan); Ozawa, Tadashi C. [Materials Development Group, Superconducting Properties Unit, National Institute for Materials Science, Sengen, Tsukuba, Ibaraki 305-0047 (Japan)

    2016-01-15

    Samarium oxyhydroxide (SmOOH) crystals were synthesized using a flux method. The as-grown crystals were yellowish, transparent, and elongated with a maximum length of approximately 1.0 mm. SmOOH adopts a monoclinic structure in the space group P2{sub 1}/m with a=0.4356 nm, b=0.3766 nm, c=0.6139 nm, and β=108.464°. The magnetic susceptibility of the SmOOH crystals exhibited typical Van Vleck paramagnetism, and the experimental data at temperatures above 200 K were in close agreement with the calculated results using a spin-orbit coupling constant λ=443 K (308 cm{sup −1}). - Highlights: • SmOOH crystals were synthesized via flux method and characterized. • Magnetic susceptibilities above 200 K agreed with theoretical Van Vleck values. • Discrepancies were observed at lower temperatures based on the crystalline field.

  1. La CEDAW y el Estado de Chile: viejas y nuevas deudas con la igualdad de género

    Directory of Open Access Journals (Sweden)

    Teresa Valdés Echenique

    2013-06-01

    Full Text Available Este artículo plantea a la CEDAW como un programa de acción pública destinado a eliminar la discriminación hacia las mujeres y lograr la igualdad formal y sustantiva entre mujeres y hombres, lo que, sin duda, resulta ambicioso y desafía las estructuras socioculturales de los países. En octubre de 2012, el Estado de Chile presentó al Comité para la Eliminación de todas las formas de Discriminación contra la Mujer el quinto y sexto informe periódico Combinado sobre el cumplimiento de la CEDAW. Las observaciones y recomendaciones del Comité de expertas al Estado de Chile, que consideró un informe presentado por el Instituto Nacional de Derechos Humanos y diversos informes sombra preparados por organizaciones de la sociedad civil, expresan antiguas y nuevas deudas de Chile en relación a la CEDAW y muestran un país marcado por desigualdades sociales y discriminaciones porgénero, con una democracia deficitaria en participación y representación, con enclaves conservadores y autoritarios que aún no reconocen los objetivos de la Convención.

  2. Sm2, a paralog of the Trichoderma cerato-platanin elicitor Sm1, is also highly important for plant protection conferred by the fungal-root interaction of Trichoderma with maize.

    Science.gov (United States)

    Gaderer, Romana; Lamdan, Netta L; Frischmann, Alexa; Sulyok, Michael; Krska, Rudolf; Horwitz, Benjamin A; Seidl-Seiboth, Verena

    2015-01-16

    The proteins Sm1 and Sm2 from the biocontrol fungus Trichoderma virens belong to the cerato-platanin protein family. Members of this family are small, secreted proteins that are abundantly produced by filamentous fungi with all types of life-styles. Some species of the fungal genus Trichoderma are considered as biocontrol fungi because they are mycoparasites and are also able to directly interact with plants, thereby stimulating plant defense responses. It was previously shown that the cerato-platanin protein Sm1 from T. virens - and to a lesser extent its homologue Epl1 from Trichoderma atroviride - induce plant defense responses. The plant protection potential of other members of the cerato-platanin protein family in Trichoderma, however, has not yet been investigated. In order to analyze the function of the cerato-platanin protein Sm2, sm1 and sm2 knockout strains were generated and characterized. The effect of the lack of Sm1 and Sm2 in T. virens on inducing systemic resistance in maize seedlings, challenged with the plant pathogen Cochliobolus heterostrophus, was tested. These plant experiments were also performed with T. atroviride epl1 and epl2 knockout strains. In our plant-pathogen system T. virens was a more effective plant protectant than T. atroviride and the results with both Trichoderma species showed concordantly that the level of plant protection was more strongly reduced in plants treated with the sm2/epl2 knockout strains than with sm1/epl1 knockout strains. Although the cerato-platanin genes sm1/epl1 are more abundantly expressed than sm2/epl2 during fungal growth, Sm2/Epl2 are, interestingly, more important than Sm1/Epl1 for the promotion of plant protection conferred by Trichoderma in the maize-C. heterostrophus pathosystem.

  3. The ternary systems Sc-Sm(Dy)-Si at 870 K

    International Nuclear Information System (INIS)

    Kotur, B.Ya.; Mokra, I.Ya.; Toporinskij, A.Ya.

    1991-01-01

    Isothermal cross sections of the ternary systems Sc-Sm-Si and Sc-Dy-Si at 870 K have been plotted. Investigation of scandium and disprosium in ternary systems have been examined by X-ray diffraction and microstructure analysis. Besides literary data on binary systems Sc-Si, Sm-Si, Dy-Si have been used. Formation of limited (Sc-Sm-Si, Sc-Dy-Si) and continuous (Sc-Dy-Si) solid solutions based on bisilicides of Sc and Sm(Dy) is discovered. Two and five ternary compounds in Sc-Sm-Si and Sc-Dy-Si systems have been determined and their crystal structure has been established. When investigating of Sc-(rare earth element)-Si ternary systems and should take into account the specific interaction of scandium and samarium with REE

  4. Efeito do treinamento físico na pressão arterial de adolescentes com obesidade Efecto del entrenamiento físico en la presión arterial de adolescentes con obesidad Effect of physical training on the blood pressure of adolescents with obesity

    Directory of Open Access Journals (Sweden)

    Breno Quintella Farah

    2012-12-01

    Full Text Available OBJETIVO: Descrever, por meio de uma revisão sistemática, os efeitos do treinamento físico sobre a pressão arterial em adolescentes com obesidade. FONTES DE DADOS: Recorreu-se à revisão sistemática de ensaios clínicos randomizados que analisaram o efeito do treinamento físico sobre a pressão arterial de adolescentes obesos, publicados em periódicos indexados nas bases de dados PubMed/Medline, Lilacs, SciELO e ISI Web of KnowledgeSM. Foram incluídos os estudos que avaliaram adolescentes publicados até 2010, e que possuíam Grupo Controle. SÍNTESE DOS DADOS: Oito estudos atenderam aos critérios de inclusão. Dois deles utilizaram exercícios de força combinados com aeróbios, enquanto seis empregaram apenas os aeróbios. Cinco estudos utilizaram intervenções complementares, sendo a nutricional a mais frequente. Quatro estudos observaram redução da pressão arterial sistólica no Grupo Exercício comparado ao Controle. Nesses quatro estudos, além da redução da pressão arterial, notou-se diminuição da massa corpórea. Todos aqueles que verificaram redução da pressão arterial utilizaram 12 a 24 semanas de exercícios aeróbios, três a seis sessões semanais, com duração de 50 a 90 minutos e intensidade entre 55 e 75% da frequência cardíaca máxima. CONCLUSÕES: O efeito do treinamento físico na pressão arterial de adolescentes obesos é controverso. A redução da pressão arterial parece ocorrer com programas de treinamento aeróbios que promovam também a redução da massa corpórea.OBJETIVO: Describir, mediante una revisión sistemática, los efectos del entrenamiento físico sobre la presión arterial en adolescentes con obesidad. FUENTES DE DATOS: Se recurrió a la revisión sistemática de ensayos clínicos aleatorios que analizaron el efecto del entrenamiento físico sobre la presión arterial de adolescentes obesos, publicados en periódicos indexados en las bases de datos PubMed/MedLine, LILACS, SciELO e

  5. Klimaforsøg med fravænnede smågrise

    DEFF Research Database (Denmark)

    Feenstra, A.

    Publikationen belyser betydningen af luftfugtighed og ventilationsluftmængder for smågrise. Undersøgelsen var led i bestræbelserne på at nedbringe energiforbruget i smågrisestalde, og resultaterne viser at ventilationsmængden kan formindskes uden skadelige virkninger for dyrene.......Publikationen belyser betydningen af luftfugtighed og ventilationsluftmængder for smågrise. Undersøgelsen var led i bestræbelserne på at nedbringe energiforbruget i smågrisestalde, og resultaterne viser at ventilationsmængden kan formindskes uden skadelige virkninger for dyrene....

  6. Purification of the spliced leader ribonucleoprotein particle from Leptomonas collosoma revealed the existence of an Sm protein in trypanosomes. Cloning the SmE homologue.

    Science.gov (United States)

    Goncharov, I; Palfi, Z; Bindereif, A; Michaeli, S

    1999-04-30

    Trans-splicing in trypanosomes involves the addition of a common spliced leader (SL) sequence, which is derived from a small RNA, the SL RNA, to all mRNA precursors. The SL RNA is present in the cell in the form of a ribonucleoprotein, the SL RNP. Using conventional chromatography and affinity selection with 2'-O-methylated RNA oligonucleotides at high ionic strength, five proteins of 70, 16, 13, 12, and 8 kDa were co-selected with the SL RNA from Leptomonas collosoma, representing the SL RNP core particle. Under conditions of lower ionic strength, additional proteins of 28 and 20 kDa were revealed. On the basis of peptide sequences, the gene coding for a protein with a predicted molecular weight of 11.9 kDa was cloned and identified as homologue of the cis-spliceosomal SmE. The protein carries the Sm motifs 1 and 2 characteristic of Sm antigens that bind to all known cis-spliceosomal uridylic acid-rich small nuclear RNAs (U snRNAs), suggesting the existence of Sm proteins in trypanosomes. This finding is of special interest because trypanosome snRNPs are the only snRNPs examined to date that are not recognized by anti-Sm antibodies. Because of the early divergence of trypanosomes from the eukaryotic lineage, the trypanosome SmE protein represents one of the primordial Sm proteins in nature.

  7. Solid-solid synthesis and structural phase transition process of SmF3

    Science.gov (United States)

    Yan, Qi-Cao; Guo, Xing-Min

    2018-04-01

    Mazes of contradictory conclusions have been obtained by previous researches about structural phase transition process of SmF3. In this paper, the single crystals of SmF3 (hexagonal and orthorhombic) were prepared by solid-solid synthesis, which have shown gradual changes in crystal growth modes with the increase temperature and holding time. Furthermore, we propose the phase transition process of in SmF3. Hexagonal symmetry of SmF3 (space group Pnma) was prepared firstly by heating Sm2O3 and NH4HF2 over 40 min at 270 °C. And then orthorhombic symmetry of SmF3 (space group P63mc) was obtained by heating hexagonal symmetry over 10 h at 650 °C. The reaction of SmF3 (hexagonal) = SmF3 (orthorhombic) is extremely sluggish at a low temperature (less than 650 °C), which was seen as a Mixed Grown Region.

  8. Synthesis and photoluminescence properties of Sm3+-doped CaWO4 nanoparticles

    International Nuclear Information System (INIS)

    Xiao Qi; Zhou Qitao; Li Ming

    2010-01-01

    The Sm 3+ -doped CaWO 4 nanoparticles were synthesized by hydrothermal method. The room temperature photoluminescence (PL) spectra of Sm 3+ -doped CaWO 4 nanoparticles doped with different Sm 3+ concentrations under 405 nm excitation have been investigated. The PL spectra showed four strong emission peaks at 460, 571, 609, and 653 nm. The first emission peak at 460 nm could be due to a structural defect of the lattice, an oxygen-deficient WO 3 complex. The other three emissions at 571, 609, and 653 nm were due to the f-f forbidden transitions of the 4f electrons of Sm 3+ , corresponding to 4 G 5/2 → 6 H 5/2 (571 nm), 6 H 7/2 (609 nm), and 6 H 9/2 (653 nm), respectively. In addition, the optimum Sm 3+ concentration in CaWO 4 nanoparticles for optical emission was determined to be 1.0%. The Sm 3+4 G 5/2 → 6 H 7/2 (609 nm) emission intensity of Sm 3+ -doped CaWO 4 nanoparticles significantly increased with the increase of Sm 3+ concentration, and showed a maximum when Sm 3+ doping content was 1.0%. If Sm 3+ concentration continued to increase, namely more than 1.0%, the Sm 3+4 G 5/2 → 6 H 7/2 emission intensity would decrease. The present materials might be a promising phosphor for white-light LED applications.

  9. Sorption of samarium in soils: influence of soil properties and Sm concentration

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez-Guinart, Oriol; Salaberria, Aitor; Rigol, Anna; Vidal, Miquel [Analytical Chemistry department, Faculty of Chemistry, University of Barcelona, Marti i Franques 1-11, 08028, Barcelona (Spain)

    2014-07-01

    Due to the fact that barriers of Deep Geological Repositories (DGR) may lose efficiency before the radioisotopes present in the High Level Radioactive Waste (HLRW) completely decay, it is possible that, in the long-term, radioactive leachates may escape from the DGR and reach the soil and water compartments in the biosphere. Therefore, it is required to examine the interaction and mobility of radionuclides present in the HLRW, or their chemical analogues, to predict the impact of their eventual incorporation in the biosphere and to assess the derived risk. Although relevant data have been recently obtained for a few radionuclides in soils, there are still some important gaps for some radionuclides, such us for samarium (Sm). Sm is a lanthanide that, besides being considered as a natural analogue of actinides, may also be present in HLRW in the form of the radioactive isotope {sup 151}Sm. The main objective of this work was to obtain sorption data (K{sub d}) of {sup 151}Sm gathered from a set of soil samples physicochemical fully-characterized (pH, texture, cationic exchange capacity, soil solution cationic composition, organic matter, carbonate and metallic oxides content, etc.). Additionally, as an alternative for testing sorption capacity of radionuclides in soils is the use of the corresponding stable isotope or a chemical analogue, the influence of Sm concentration was also checked. To evaluate {sup 151}Sm sorption, batch assays were carried out for each soil sample, which consisted in a pre-equilibration step of 2 g of each soil with 50 ml of double deionised water, and a subsequent equilibration step with the same solution, but labelled with {sup 151}Sm. The activity of {sup 151}Sm in initial and final solutions was measured by liquid scintillation and K{sub d} ({sup 151}Sm) data were calculated. The reversibly sorbed fraction was estimated by the application of a single extraction test, with double deionised water, to soil residues coming from the previous

  10. Determination of the {sup 151}Sm half-life

    Energy Technology Data Exchange (ETDEWEB)

    Be, Marie-Martine; Cassette, Philippe [CEA, LIST, Gif sur Yvette (France). LNE-Laboratoire National Henri Becquerel; Isnard, Helene [CEA-LANIE, Gif sur Yvette (France); and others

    2015-07-01

    New measurements have been undertaken to determine the half-life of {sup 151}Sm. A pure {sup 151}Sm solution was obtained after chemical separation from a samarium solution resulting from the dissolution of an irradiated samarium sample. The concentration of {sup 151}Sm in the solution was measured by mass spectrometry, combined with the isotope dilution technique. The activity of the solution was measured by liquid scintillation counting by six European laboratories as part of an international comparison. These combined results lead to a half-life of T{sub 1/2} = 94.6(6)a.

  11. Anti-skin-aging benefits of exopolymers from Aureobasidium pullulans SM2001.

    Science.gov (United States)

    Kim, Kyung Hu; Park, Soo Jin; Lee, Ji Eun; Lee, Young Joon; Song, Chang Hyun; Choi, Seong Hun; Ku, Sae Kwang; Kang, Su Jin

    2014-01-01

    There have been many attempts to search for affordable and effective functional cosmetic ingredients, especially from natural sources. As research into developing a functional cosmetic ingredient, we investigated whether exopolymers from Aureobasidium pullulans SM2001 (E-AP-SM2001) exert antioxidant, antiwrinkle, whitening, and skin moisturizing effects. Antioxidant effects of E-AP-SM2001 were determined by measuring free radical scavenging capacity and superoxide dismutase (SOD)-like activity. Antiwrinkle effects were assessed through the inhibition of hyaluronidase, elastase, collagenase, and matrix metalloproteinase (MMP)-1. Whitening effects were measured by tyrosinase inhibition assay, and by melanin formation test in B16/F10 melanoma cells. Skin moisturizing effects were detected by mouse skin water content test. E-AP-SM2001 showed potent DPPH radical scavenging activity and SOD-like effects. Additionally, hyaluronidase, elastase, collagenase, and MMP-1 activities were significantly inhibited by E-AP-SM2001. We also observed that E-AP-SM2001 effectively reduced melanin production by B16/F10 melanoma cells and mushroom tyrosinase activities. Furthermore, significant increases in skin water content were detected in E-AP-SM2001- treated mouse skin, as compared with vehicle-treated control skin. Notably, a mask pack containing E-AP-SM2001 showed a >twofold more extensive moisturizing effect compared with one containing Saccharomycopsis ferment filtrate. Our results suggest that E-AP-SM2001 has adequate antiaging, antiwrinkle, and whitening benefits and skin moisturizing effect. These effects involve reducing hyaluronidase, elastase, collagenase, and MMP-1 activities, as well as inhibition of melanin production and tyrosinase activities. Therefore, the antioxidant E-AP-SM2001 may serve as a predictable functional ingredient.

  12. Robust velocity and load control of a steam turbine in a combined cycle thermoelectric power station; Control robusto de velocidad y carga de una turbina de vapor en una central termoelectrica de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Reyes Archundia, Enrique

    1998-12-31

    of the computation, the programming languages and the numerical methods allow to develop mathematical models that simulate in an approximate manner the processes to control, as it is the case of the combined cycle thermoelectric power station and in this way making the evaluation of algorithms of modern control possible. In chapter I a functional description of the steam turbine process is given. Since this belongs to a combined cycle thermoelectric power station, it is begun with the description of this power station, later to emphasize the subsystem of the steam turbine and emphasize each one of the elements that comprise this last one. [Espanol] Este trabajo de investigacion esta orientado a disenar, desarrollar y validar un algoritmo de control moderno, que permita la obtencion de mejores desempenos en el control de velocidad de una turbina de vapor perteneciente a una central termoelectrica de ciclo combinado, en todo el intervalo de operacion, asi como la obtencion de mejores desempenos en el control de la cantidad de megawatts generados por la misma cuando esta acoplada a un generador electrico, comparando el desempeno con el obtenido mediante el controlador convencional existente. Los cambios en la referencia de velocidad o carga, son a solicitud del operador y se dan siempre en forma de rampa, indicando la rapidez con la que se desea efectuar el cambio de valor en la referencia. Esta es la razon por la cual el objetivo principal del control a disenar es realizar un buen seguimiento a referencias del tipo rampa. En el subsistema de la turbina de vapor existente el inconveniente de que las valvulas que regulan el flujo de vapor hacia la turbina, presentan un acoplamiento con la valvula del bypass que permite derivar el flujo de vapor hacia el condensador principal sin tener que pasar por la turbina. Es por esto que se propone un control multivariable que contemple la interaccion que se presenta entre las valvulas antes mencionadas, partiendo de un diseno

  13. Electrochemical preparation of Al–Sm intermetallic compound whisker in LiCl–KCl Eutectic Melts

    International Nuclear Information System (INIS)

    Ji, De−Bin; Yan, Yong−De; Zhang, Mi−Lin; Li, Xing; Jing, Xiao−Yan; Han, Wei; Xue, Yun; Zhang, Zhi−Jian; Hartmann, Thomas

    2015-01-01

    Highlights: • The reduction process of Sm(III) was investigated in LiCl–KCl melt on an aluminum electrode at 773 K. • Al–Sm alloy with different phase structure (Al 2 Sm and Al 3 Sm) was prepared by potentiostatic electrolysis on an aluminum electrode with the change of electrolytic potentials and time in LiCl–KCl–SmCl 3 melts. • Al − Sm alloy containing whiskers (Al 4 Sm) was obtained by potentiostatic electrolysis (−2.10 V) on an aluminum electrode for 7 hours with the change of electrolytic temperature and cooling rate in LiCl–KCl–SmCl 3 (16.5 wt. %) melts. The results from micro–hardness test and potentiodynamic polarization test show the micro hardness and corrosion property are remarkably improved with the help of Al–Sm intermetallic compound whiskers. - Abstract: This work presents the electrochemical study of Sm(III) on an aluminum electrode in LiCl–KCl melts at 773 K by different electrochemical methods. Three electrochemical signals in cyclic voltammetry, square wave voltammetry, open circuit chronopotentiometry, and cathode polarization curve are attributed to different kinds of Al–Sm intermetallic compounds, Al 2 Sm, Al 3 Sm, and Al 4 Sm, respectively. Al–Sm alloy with different phase structure (Al 2 Sm and Al 3 Sm) could be obtained by the potentiostatic electrolysis with the change of electrolytic potentials and time. Al–Sm alloy containing whiskers (Al 4 Sm) was obtained by potentiostatic electrolysis (−2.10 V) on an aluminum electrode for 7 hours with the change of electrolytic temperature and cooling rate in LiCl–KCl–SmCl 3 (16.5 wt. %) melts. The XRD and SEM&EDS were employed to investigate the phase composition and microstructure of Al–Sm alloy. SEM analysis shows that lots of needle−like precipitates formed in Al–Sm alloy, and their ratios of length to diameter are found to be greater than 10 to 1. The TEM and electron diffraction pattern were performed to investigate the crystal structure of the

  14. Estudio del efecto de los ácidos grasos poliinsaturados, polifenoles e iminociclitoles sobre marcadores relacionados con el síndrome metabólico

    OpenAIRE

    Molinar Toribio, Eunice María

    2015-01-01

    La prevalencia del denominado Síndrome Metabólico (SM) está aumentando rápidamente en todo el mundo a tal punto que se está convirtiendo en un problema de salud global. Se conoce como SM a un conjunto de factores de riesgo para la salud, que incluyen la obesidad (obesidad central), resistencia a la insulina (RI), dislipidemia, hígado graso no alcohólico y la hipertensión. Estas alteraciones se han relacionado con un alto riesgo de desarrollar diabetes tipo 2 (DM2) y enfermedades cardiovascula...

  15. Estudio del efecto de los ácidos grasos poliinsaturados, polifenoles e iminociclitoles sobre marcadores relacionados con el síndrome metabólico

    OpenAIRE

    Molinar Toribio, Eunice María

    2015-01-01

    [spa] La prevalencia del denominado Síndrome Metabólico (SM) está aumentando rápidamente en todo el mundo a tal punto que se está convirtiendo en un problema de salud global. Se conoce como SM a un conjunto de factores de riesgo para la salud, que incluyen la obesidad (obesidad central), resistencia a la insulina (RI), dislipidemia, hígado graso no alcohólico y la hipertensión. Estas alteraciones se han relacionado con un alto riesgo de desarrollar diabetes tipo 2 (DM2) y enfermedades cardiov...

  16. Isotope shifts and hyperfine splittings in 144-154Sm I

    International Nuclear Information System (INIS)

    England, J.G.; Grant, I.S.; Newton, G.W.A.; Walker, P.M.

    1990-01-01

    The isotope shifts and hyperfine splittings have been measured in 144-154 Sm I using the crossed-beam laser fluorescence method. Transitions at 598.98 nm and 570.68 nm were investigated for all isotopes except 146 Sm and 153 Sm, in which measurements were only obtained at 570.68 nm. Laser-induced fluorescence has not previously been reported for 145 Sm. The magnetic dipole and electric quadrupole moments of the odd isotopes and the changes in mean square radii of the even ones are shown to be consistent with the information obtained from nuclear spectroscopy. (author)

  17. Efectos combinados de la ampliación de la atención primaria de salud y de las transferencias condicionadas de dinero en efectivo sobre la mortalidad infantil en Brasil, 1998–2010*

    Science.gov (United States)

    Guanais, Frederico C.

    2015-01-01

    Objetivos. Examiné los efectos combinados del acceso a la atención primaria mediante el Programa de Salud Familiar (PSF) y las transferencias condicionadas de dinero en efectivo del Programa Bolsa Familia (PBF) sobre la mortalidad infantil posneonatal (MIPN) en Brasil. Métodos. Empleé un análisis ecológico longitudinal usando datos en panel de 4 583 municipios brasileños de 1998 al 2010, con 54 253 observaciones en total. Estimé modelos de regresión de efectos fijos por mínimos cuadrados ordinarios, con la tasa de MIPN como la variable dependiente y el PSF, el PBF y sus interacciones como las principales variables independientes de interés. Resultados. La asociación de una mayor cobertura del PSF con una menor tasa de MIPN se volvió más fuerte conforme aumentaba la cobertura del PBF. En los promedios de todas las demás variables, cuando la cobertura de PBF era 25%, la MIPN predicha fue 5,24 (intervalo de confianza [IC] de 95% = 4,95, 5,53) para una cobertura del PSF de 0%, y de 3,54 (IC de 95% = 2,77, 4,31) para una cobertura del PSF de 100%. Cuando la cobertura del PBF era de 60%, la MIPN predicha fue 4,65 (IC de 95% = 4,36, 4,94) para una cobertura del PSF de 0%, y de 1,38 (IC de 95% = 0,88, 1,89) para una cobertura del PSF de 100%. Conclusiones. El efecto del PSF depende de la ampliación del PBF. Para las poblaciones empobrecidas y subatendidas, la combinación de intervenciones tanto del lado de la oferta como del lado de la demanda podría ser necesaria para mejorar los resultados en salud.

  18. Guided ion beam and theoretical studies of the bond energy of SmS+

    Science.gov (United States)

    Armentrout, P. B.; Demireva, Maria; Peterson, Kirk A.

    2017-12-01

    Previous work has shown that atomic samarium cations react with carbonyl sulfide to form SmS+ + CO in an exothermic and barrierless process. To characterize this reaction further, the bond energy of SmS+ is determined in the present study using guided ion beam tandem mass spectrometry. Reactions of SmS+ with Xe, CO, and O2 are examined. Results for collision-induced dissociation processes with all three molecules along with the endothermicity of the SmS+ + CO → Sm+ + COS exchange reaction are combined to yield D0(Sm+-S) = 3.37 ± 0.20 eV. The CO and O2 reactions also yield a SmSO+ product, with measured endothermicities that indicate D0(SSm+-O) = 3.73 ± 0.16 eV and D0(OSm+-S) = 1.38 ± 0.27 eV. The SmS+ bond energy is compared with theoretical values characterized at several levels of theory, including CCSD(T) complete basis set extrapolations using all-electron basis sets. Multireference configuration interaction calculations with explicit spin-orbit calculations along with composite thermochemistry using the Feller-Peterson-Dixon method and all-electron basis sets were also explored for SmS+, and for comparison, SmO, SmO+, and EuO.

  19. Evaluación de la eficacia in vitro e in vivo del tratamiento antimicrobiano combinado por el tablero de damas Effectiveness of a combined antimicrobial treatment by means of the draughtboard. In vitro and in vivo assessment

    Directory of Open Access Journals (Sweden)

    María Espino Hernández

    2009-08-01

    Full Text Available El presente trabajo tuvo como objetivo, evaluar la eficacia clínica del tratamiento antimicrobiano combinado mediante pruebas de sinergismo in vitro y determinar la eficacia del procedimiento empleado para orientar la aplicación de estas formas de tratamiento en el paciente con sepsis por bacterias con resistencia variada. Se evaluó el tratamiento aplicado a 163 recién nacidos con sepsis corroborada por hemocultivo positivo en el Hospital Ginecobstétrico Universitario "América Arias", durante el periodo de enero de 1993 a diciembre de 2000, por el método tablero de damas (checkerboard en placas de microtitulación. Las combinaciones de fármacos sinérgicas in vitro presentaron una alta probabilidad de eficacia clínica, independiente del patrón de susceptibilidad del microorganismo aun frente a cepas resistentes a los 2 antimicrobianos utilizados en el tratamiento. Todos los resultados antagónicos in vitro se correspondieron con un fallo clínico terapéutico. El procedimiento utilizado puede constituir una valiosa herramienta para orientar la terapéutica en pacientes con sepsis por microorganismos resistentes.The aim of present paper was to evaluate clinical effectiveness of combined antimicrobial treatment by means of in vitro synergism tests and to determine effectiveness of used procedure to direct applications of these treatment strategies in patient presenting with sepsis from varied resistance bacteria. Treatment applied was assessed in 163 newborn patients presenting with sepsis from positive hemoculture in "America Arias" University Gynecology-Obstetrics Hospital from January 1993 to December 2000, by checkerboard method in microtritate plates. In vitro synergic drug combinations showed a high probability of clinical effectiveness, independently of susceptibility pattern of microorganism event versus resistant strains to both antimicrobials used in treatment. All in vitro antagonistic results correspond both with a

  20. Prediction of the new efficient permanent magnet SmCoNiFe3

    Science.gov (United States)

    Söderlind, P.; Landa, A.; Locht, I. L. M.; Åberg, D.; Kvashnin, Y.; Pereiro, M.; Däne, M.; Turchi, P. E. A.; Antropov, V. P.; Eriksson, O.

    2017-09-01

    We propose a new efficient permanent magnet, SmCoNiFe3, which is a development of the well-known SmCo5 prototype. More modern neodymium magnets of the Nd-Fe-B type have an advantage over SmCo5 because of their greater maximum energy products due to their iron-rich stoichiometry. Our new magnet, however, removes most of this disadvantage of SmCo5 while preserving its superior high-temperature efficiency over the neodymium magnets. We show by means of first-principles electronic-structure calculations that SmCoNiFe3 has very favorable magnetic properties and could therefore potentially replace SmCo5 or Nd-Fe-B types in various applications.

  1. EXERCÍCIO FÍSICO AERÓBIO, RESISTIDO E COMBINADO: efeitos na pressão arterial em indivíduos hipertensos

    OpenAIRE

    da Silva, Julia Spanhol; Bona, Cleiton Chiamonti

    2014-01-01

    Objetivo: analisar possíveis efeitos na pressão arterial de três sujeitos hipertensos, a partir da aplicação de três tipos de exercícios: aeróbio, resistido e combinado. Método: o estudo de caso utilizou, como instrumento, equipamento manual de verificação de pressão arterial, monitor de frequência cardíaca Polar, ficha de anotações da pressão arterial e frequência cardíaca. Os sujeitos analisados realizaram as atividades em academia do município de Passo Fundo-RS. Resultados e considerações ...

  2. Superconductivity in Sm-doped CaFe2As2 single crystals

    Science.gov (United States)

    Dong-Yun, Chen; Bin-Bin, Ruan; Jia, Yu; Qi, Guo; Xiao-Chuan, Wang; Qing-Ge, Mu; Bo-Jin, Pan; Tong, Liu; Gen-Fu, Chen; Zhi-An, Ren

    2016-06-01

    In this article, the Sm-doping single crystals Ca1 - x Sm x Fe2As2 (x = 0 ˜ 0.2) were prepared by the CaAs flux method, and followed by a rapid quenching treatment after the high temperature growth. The samples were characterized by structural, resistive, and magnetic measurements. The successful Sm-substitution was revealed by the reduction of the lattice parameter c, due to the smaller ionic radius of Sm3+ than Ca2+. Superconductivity was observed in all samples with onset T c varying from 27 K to 44 K upon Sm-doping. The coexistence of a collapsed phase transition and the superconducting transition was found for the lower Sm-doping samples. Zero resistivity and substantial superconducting volume fraction only happen in higher Sm-doping crystals with the nominal x > 0.10. The doping dependences of the c-axis length and onset T c were summarized. The high-T c observed in these quenched crystals may be attributed to simultaneous tuning of electron carriers doping and strain effect caused by lattice reduction of Sm-substitution. Project supported by the National Natural Science Foundation of China (Grant No. 11474339), the National Basic Research Program of China (Grant Nos. 2010CB923000 and 2011CBA00100), and the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB07020100).

  3. Evaluation the homogenisation behaviour of Sm-Fe-Nb materials by Moessbauer spectroscopy

    International Nuclear Information System (INIS)

    Sinan, S. A.; Muryaed, Y.; Alhweg, F. A.

    2004-01-01

    The microstructure of cast and annealed Sm-Fe-Nb materials were investigated by Moessbauer spectroscopy. The aim of the present work is to study the effect of Nb additions upon the microstructure of Sm 2 Fe 17 material and evaluation the homogenisation behaviour of different Sm-Fe-Nb materials. The niobium free cast material consisting of the Sm 2 Fe 17 phase and significant amounts of the free iron (α -Fe). Therefore, the homogenisation process is necessary to eliminate the free iron and produce a single Sm 2 Fe 17 phase material. This process takes long annealing time, up to seven days. The Sm 9 .5 Fe 8 7.5 Nb 3 alloy contains the lowest amount of α-Fe among, the Sm-Fe-Nb materials. Thus the homogenisation step was carried out with treatment time (12 hours) smaller than the reported annealing time of Nb-free material (Sm 2 Fe 17 ). Therefore, the addition of at 3% Nb reduces the manufacturing cost of the Sm 2 Fe 17 and makes this based material for permanent magnets, more industrially desirable, due to elimination the free iron with lowest treatment time. Also it was found that the existence of the paramagnetic NbFe 2 phase becomes higher after the homogenisation process, which can be explained due to the diffusion of Nb from Sm 2 Fe 17 phase to paramagnetic NbFe 2 phase, during the annealing process. (authors)

  4. The SM and MIR reactors operation experience

    International Nuclear Information System (INIS)

    Kuprienko, V.A.; Klinov, A.V.; Svyatkin, M.N.; Shamardin, V.K.

    1995-01-01

    The SM and MIR operation experience show that continuous work on the problem of ageing, in all its aspects, allows for prolongation of the research plant life cycle by several folds as compared to the initial project. The redesigned SM-3 reactor will operate for another 20 years. The similar result is expected from the MIR planned reconstruction which scope will be the topic of future presentations. (orig.)

  5. Aligned, plasma sprayed SmCo5 deposits

    International Nuclear Information System (INIS)

    Kumar, K.; Das, D.

    1986-01-01

    Highly aligned SmCo 5 deposits were produced using plasma spraying. c-axis alignment, normal to the plane of the deposit, was achieved by depositing the Sm-Co alloys on steel substrates maintained at high temperatures. The substrates were heated by the plasma flame to obtain the high temperatures. The attainment of a range of substrate temperatures was made possible through control over the geometry of the substrate

  6. The electrodeposition of 149Sm targets for (n,α) studies

    International Nuclear Information System (INIS)

    Ingelbrecht, C.; Ambeck-Madsen, J.; Teipel, K.; Robouch, P.; Arana, G.; Pomme, S.

    1999-01-01

    A method of electrodeposition from ethanol was developed for the production of 149 Sm targets of area 50x60 mm 2 to be used for (n,α) experiments. Targets of 60 μg cm -2 Sm were obtained with a Sm yield of 50% and a Sm mass fraction of 35% after calcination of the layers at 450 deg. C. Target substrates were 20 μm aluminium foils mounted on brass frames. A water cooling jig was constructed to protect the glue used for mounting during the calcination process. The layers were characterized by inductively coupled plasma source mass spectrometry (ICP-MS) and by neutron activation analysis (NAA)

  7. Role of SM22 in the differential regulation of phasic vs. tonic smooth muscle

    Science.gov (United States)

    Ali, Mehboob

    2015-01-01

    Preliminary proteomics studies between tonic vs. phasic smooth muscles identified three distinct protein spots identified to be those of transgelin (SM22). The latter was found to be distinctly downregulated in the internal anal sphincter (IAS) vs. rectal smooth muscle (RSM) SMC. The major focus of the present studies was to examine the differential molecular control mechanisms by SM22 in the functionality of truly tonic smooth muscle of the IAS vs. the adjoining phasic smooth muscle of the RSM. We monitored SMC lengths before and after incubation with pFLAG-SM22 (for SM22 overexpression), and SM22 small-interfering RNA. pFLAG-SM22 caused concentration-dependent and significantly greater relaxation in the IAS vs. the RSM SMCs. Conversely, temporary silencing of SM22 caused contraction in both types of the SMCs. Further studies revealed a significant reverse relationship between the levels of SM22 phosphorylation and the amount of SM22-actin binding in the IAS and RSM SMC. Data showed higher phospho-SM22 levels and decreased SM22-actin binding in the IAS, and reverse to be the case in the RSM SMCs. Experiments determining the mechanism for SM22 phosphorylation in these smooth muscles revealed that Y-27632 (Rho kinase inhibitor) but not Gö-6850 (protein kinase C inhibitor) caused concentration-dependent decreased phosphorylation of SM22. We speculate that SM22 plays an important role in the regulation of basal tone via Rho kinase-induced phosphorylation of SM22. PMID:25617350

  8. A metastable Mg11Sm phase obtained by rapid solidification

    International Nuclear Information System (INIS)

    Budurov, S.

    1993-01-01

    Molten Mg-Sm alloys with a Sm concentration of 4.93, 6.86, and 8.35 at.% were rapidly soldified with the aid of a shock wave gun device. Investigations of the obtained splats were performed with the aid of DSC, X-ray analysis, and metallography. Rapid soldification of the eutectic MgSm 8.35 alloy forms a new Im3m-type phase. (orig.)

  9. Low temperature preparation and superconductivity of F-doped SmFeAsO

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y.L.; Cui, Y.J. [Key Laboratory of Magnetic Levitation Technologies and Maglev Trains (Ministry of Education of China), Superconductivity R and D Center (SRDC), Mail Stop 165, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China); Cheng, C.H. [School of Materials Science and Engineering, University of New South Wales, Sydney, 2052 NSW (Australia); Yang, Y.; Wang, L.; Li, Y.C.; Zhang, Y. [Key Laboratory of Magnetic Levitation Technologies and Maglev Trains (Ministry of Education of China), Superconductivity R and D Center (SRDC), Mail Stop 165, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China); Zhao, Y., E-mail: yzhao@swjtu.edu.c [Key Laboratory of Magnetic Levitation Technologies and Maglev Trains (Ministry of Education of China), Superconductivity R and D Center (SRDC), Mail Stop 165, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China); School of Materials Science and Engineering, University of New South Wales, Sydney, 2052 NSW (Australia)

    2010-11-01

    A low temperature (1100 deg. C) process of preparing F-doped SmFeAsO samples has been developed using SmF{sub 3} with nanometer scale as the source of fluorine. A series of the SmFeAsO{sub 1-x}F{sub x} (x = 0, 0.05, 0.1, 0.15, 0.2, 0.25, 0.3) samples have been prepared using the present method. Compared with previous reports, the present SmF{sub 3} is more effective to introduce F into SmFeAsO system in which a transition temperature of 39 K can be observed when x = 0.05. The superconductivity is definitely enhanced with the increasing F-doping level. All the samples presented to be layered structure and the crystal particle size is about three times larger with sintering time increasing from 36 h to 48 h. Except for the nanometer scale of SmF{sub 3}, the flux effect of SmF{sub 3} is recognized to be another reason for the decrease of the sintering temperature. Further more, a relatively large amount of SmF{sub 3} was also employed in the raw materials to introduce excessive F and this has induced higher T{sub c} (55 K) in SmFeAsO{sub 0.8}F{sub 0.2+{delta}}system.

  10. Current utilization of research reactor on radioisotopes production in China

    International Nuclear Information System (INIS)

    Liu Yishu

    2000-01-01

    The main technical parameters of the four research reactors and their current utilization status in radioisotope manufacture and labeling compounds preparation are described. The radioisotopes, such as Co-60 sealed source, Ir-192 sealed source, γ-knife source, I-131, I-125, Sm-153, P-32 series products, In-113m generator, Tc-99m gel generator, Re-188 gel generator, C-14, Ba-131, Sr-89, 90 Y, etc., and their labeling compounds prepared from the reactor produced radionuclides, such as I-131-MIBG, I-131-Hippure, I-131-capsul, Sm-153-EDTMP, Re-186-HEDP, Re-186-HA, C-14-urea, and radioimmunoassay kits etc. are presented as well. Future development plan of radioisotopes and labeling compounds in China is also given. Simultaneously, the possibility and methods of bilateral or multilateral co-operation in utilization of research reactor, personnel and technology exchange of radioisotope production and labeling compounds is also discussed. (author)

  11. Present status of OAP radioisotope production

    International Nuclear Information System (INIS)

    Charoen, Sakda

    2006-01-01

    Radioisotope Production Program (RP), Office of Atoms for Peace (OAP) is a non-profit government organization which responsible for research development and service of radioisotopes. Several research works on radioisotope production have been carried on at OAP. The radioisotope products of successful R and D have been routinely produced to supply for medical, agriculture and research application. The main products are 131 I (solution and capsule), 131 I-MIBG, 131 I-Hippuran, 153 Sm-EDTMP, 153 Sm-HA, and 99m Tc-radiopharmaceutical kits to serve local users. Radioisotopes are very beneficial for science and human welfare so as almost of our products and services are mainly utilized for medical purpose for both diagnosis and therapy. OAP has a policy to serve and response to that community by providing radioisotopes and services with high quality but reasonable price. This policy will give the opportunity to the community to utilize these radioisotopes for their healthcare. (author)

  12. Current utilization of research reactor on radioisotopes production in China

    Energy Technology Data Exchange (ETDEWEB)

    Liu Yishu [Nuclear Power Institute of China, Chengdu (China)

    2000-10-01

    The main technical parameters of the four research reactors and their current utilization status in radioisotope manufacture and labeling compounds preparation are described. The radioisotopes, such as Co-60 sealed source, Ir-192 sealed source, {gamma}-knife source, I-131, I-125, Sm-153, P-32 series products, In-113m generator, Tc-99m gel generator, Re-188 gel generator, C-14, Ba-131, Sr-89, {sup 90}Y, etc., and their labeling compounds prepared from the reactor produced radionuclides, such as I-131-MIBG, I-131-Hippure, I-131-capsul, Sm-153-EDTMP, Re-186-HEDP, Re-186-HA, C-14-urea, and radioimmunoassay kits etc. are presented as well. Future development plan of radioisotopes and labeling compounds in China is also given. Simultaneously, the possibility and methods of bilateral or multilateral co-operation in utilization of research reactor, personnel and technology exchange of radioisotope production and labeling compounds is also discussed. (author)

  13. The glomerular parietal epithelial cell's responses are influenced by SM22 alpha levels.

    Science.gov (United States)

    Naito, Shokichi; Pippin, Jeffrey W; Shankland, Stuart J

    2014-11-06

    Studies have shown in several diseases initially affecting podocytes, that the neighboring glomerular parietal epithelial cells (PECs) are secondarily involved. The PEC response might be reparative under certain circumstances, yet injurious under others. The factors governing these are not well understood. We have shown that SM22α, an actin-binding protein considered a marker of smooth muscle differentiation, is upregulated in podocytes and PECs in several models of podocyte disease. However, the impact of SM22α levels on PECs is not known. Experimental glomerular disease, characterized by primary podocyte injury, was induced in aged-matched SM22α+/+ and SM22α-/-mice by intraperitoneal injection of sheep anti-rabbit glomeruli antibody. Immunostaining methods were employed on days 7 and 14 of disease. The number of PEC transition cells, defined as cells co-expressing a PEC protein (PAX2) and podocyte protein (Synaptopodin) was higher in diseased SM22α-/-mice compared with SM22α+/+mice. WT1 staining along Bowman's capsule is higher in diseased SM22α-/-mice. This was accompanied by increased PEC proliferation (measured by ki-67 staining), and an increase in immunostaining for the progenitor marker NCAM, in a subpopulation of PECs in diseased SM22α-/-mice. In addition, immunostaining for vimentin and alpha smooth muscle actin, markers of epithelial-to-mesenchymal transition (EMT), was lower in diseased SM22α-/-mice compared to diseased SM22α+/+mice. SM22α levels may impact how PECs respond following a primary podocyte injury in experimental glomerular disease. Absent/lower levels favor an increase in PEC transition cells and PECs expressing a progenitor marker, and a lower EMT rate compared to SM22α+/+mice, where SM22 levels are markedly increased in PECs.

  14. Factores que controlan las propiedades texturales de arcillas intercaladas con disoluciones de circonio y aluminio

    Directory of Open Access Journals (Sweden)

    Gil, A.

    2000-08-01

    Full Text Available The texture development of a saponite and a montmorillonite, intercalated with zirconium and aluminium oligomers, after calcination at 500 ºC has been studied. Remarkable differences were observed among samples, depending on the source of the intercalating polycations and the parent material. On calcining, the alumina pillared clays suffered noticeable specific surface area and micropore volume losses, which have been related to the interlayer and interpillar distances of the samples. On the contrary, the zirconia pillared clays showed a slight surface area increase, which affected both micropores and mesopores and could be due to the combined effect of the thermal decomposition of the zirconium oligomers and the possible presence of mesoporous ZrO2 particles.

    En este trabajo se ha estudiado la evolución de las propiedades texturales de una saponita y una montmorillonita intercaladas con disoluciones de circonio y aluminio tras calcinación a 500 ºC. Los sólidos presentaron un diferente comportamiento en función de la naturaleza de la disolución de intercalación y de la arcilla empleada. Tras calcinación, la superficie específica y el volumen microporoso de las arcillas intercaladas con disoluciones de aluminio disminuyeron de manera importante, lo cual se ha relacionado con las distancias interlaminar e interpilar que presentaron los materiales intercalados. Por contra, las superficies específicas de las arcillas intercaladas con disoluciones de circonio aumentaron, probablemente gracias al efecto combinado de la descomposición térmica de los ligandos orgánicos unidos al circonio en los policationes y la posible presencia de partículas mesoporosas de ZrO2 sobre la superficie de los sólidos.

  15. Thermogravimetric and Magnetic Studies of the Oxidation and Reduction Reaction of SmCoO3 to Nanostructured Sm2O3 and Co

    Science.gov (United States)

    Kelly, Brian; Cichocki, Ronald; Poirier, Gerald; Unruh, Karl

    The SmCoO3 to nanostructured Sm2O3 and Co oxidation and reduction reaction has been studied by thermogravimetric analysis (TGA) measurements in forming gas (FG) and inert N2 atmospheres, x-ray diffraction (XRD) and vibrating sample magnetometry (VSM). The TGA measurements showed two clearly resolvable reduction processes when heating in FG, from the initial SmCoO3 phase through an intermediate nanostructured mixture of Sm2O3 and CoO when heated to 330°C for several minutes, and then the conversion of CoO to metallic Co when heated above 500°C. These phases were confirmed by XRD and VSM. Similar measurements in N2 yielded little mass change below 900°C and coupled reduction processes at higher temperatures. Isoconversional measurements of the CoO to Co reduction reaction in FG yielded activation energies above 2eV/atom in the nanostructured system. This value is several times larger than those reported in the literature or obtained by similar measurements of bulk mixtures of Sm2O3 and CoO, suggesting the nanostructuring was the source of the large increase in activation energy.

  16. Synthesis and physicochemical analysis of Sm (II, III) acetylacetone chelate complexes

    International Nuclear Information System (INIS)

    Kostyuk, N.N.; Dik, T.A.; Trebnikov, A.G.

    2004-01-01

    Sm (II, III) acetylacetone chelate complexes were synthesized by electrochemical method. It was shown that anode dissolution of the metal samarium over acetylacetone leads to formation of the Sm (II, III) chelate complexes: xSm(acac)2 · ySm(acac)3 · zH(acac). Factors x, y and z depend on quantity of the electricity, which flew through the electrolysis cell. The compositions of the obtained substances were confirmed by the physicochemical analysis (ultimate analysis, IR-, mass spectroscopy and thermal analysis (thermogravimetric, isothermal warming-up and differential scanning colorimetry). (Authors)

  17. Propuesta de un material metodológico sobre la enseñanza de los elementos técnicos del boxeo en los combinados deportivos del municipio Pinar del Río

    Directory of Open Access Journals (Sweden)

    Porfirio Pérez Fuentes

    2007-12-01

    Full Text Available Al impartir los programas de Boxeo en nuestra Facultad nos llamó la atención que al evaluar los contenidos relacionados con metodología de la enseñanza de los elementos técnicos de este deporte se presentaban frecuentes dificultades que, sin dudas, constituyen obstáculos para la correcta aplicación del proceso de enseñanza. Dentro de los alumnos se incluían muchos que pertenecían al curso de trabajadores, es decir, ya entrenadores de varios municipios, esto nos hizo comprender el carácter generalizado de dichas deficiencias y la necesidad de un documento que abordara ell tema mencionado sobre el cual no se disponía bibliografía especializada. Para confirmarlo fue aplicada una encuesta a entrenadores de los combinados del municipio Pinar de Río por lo que surge la propuesta de este material con el que los entrenadores y futuros especialistas del referido deporte pueden recibir una orientación precisa y objetiva en cuanto a cómo enseñar, pues para la elaboración del mismo se tomaron planteamientos generales de varios autores sobre métodos y procedimientos en el entrenamiento deportivo en lo relativo a la forma de aplicación de los pasos metodológicos de cada elemento a enseñar. Este material ya está siendo utilizado en nuestra Facultad y su contenido fue solicitado por la Academia Provincial para impartir la preparación metodológica de habilitados y entrenadores dada la importancia que le concedieron.

  18. Study on cellular survival adaptive response induced by low dose irradiation of 153Sm

    International Nuclear Information System (INIS)

    Zhu Shoupeng; Xiao Dong

    1999-01-01

    The present study engages in determining whether low dose irradiation of 153 Sm could cut down the responsiveness of cellular survival to subsequent high dose exposure of 153 Sm so as to make an inquiry into approach the protective action of adaptive response by second irradiation of 153 Sm. Experimental results indicate that for inductive low dose of radionuclide 153 Sm 3.7 kBq/ml irradiated beforehand to cells has obvious resistant effect in succession after high dose irradiation of 153 Sm 3.7 x 10 2 kBq/ml was observed. Cells exposed to low dose irradiation of 153 Sm become adapted and therefore the subsequent cellular survival rate induced by high dose of 153 Sm is sufficiently higher than high dose of 153 Sm merely. It is evident that cellular survival adaptive response could be induced by pure low dose irradiation of 153 Sm only

  19. PVD Ti coatings on Sm-Co magnets

    International Nuclear Information System (INIS)

    Bovda, O.M.; Bovda, V.O.; Garkusha, I.E.; Leonov, S.O.; Onishchenko, L.V.; Tereshin, V.I.; Totrika, O.S.; Chen, C.H.

    2008-01-01

    The combination of conventional ion-plasma deposition (PVD) and pulsed plasma technologies (PPT) has been applied for rare-earth Sm-Co based magnets, to provide them with enhanced corrosion resistance. The influence of pulsed plasma treatment on Sm-Co magnets with deposited titanium PVD coatings has been investigated. It was revealed that thickness of modified layer significantly depends on the thickness of initial titanium film and plasma treatment regimes. As a result of plasma treatment with energy density of 30 J/cm 2 and pulse duration of ∼ 5 μs fine-grained layer with the thickness of 70 microns has been formed on the Sm-Co magnet with pure titanium film of 50 micron. According to SEM analyses considerable diffusion of titanium to the bulk of the magnet, on the depth of 20 microns, took place. Such reaction enhances strong bonding between the coating and the magnet

  20. Magnetic anisotropies in SmCo thin films

    International Nuclear Information System (INIS)

    Chen, K.

    1993-01-01

    A systemic study of the deposition processes and magnetic properties for the Sm-Co film system has been carried out. Films of Sm-Co system with various magnetic anisotropies have been synthesized through sputter deposition in both crystalline and amorphous phases. The origins of various anisotropies have been studied. Thermalized sputter deposition process control was used to synthesize Fe enriched Sm-Co films with rhombohedral Th 2 Zn 17 type structure. The film exhibited unusually strong textures with the crystallographic c axes of the crystallites aligned in the film plane. A large anisotropy was resulted with easy axis in the film plane. A well defined and large in-the-film-plane anisotropy of exceptionally high value of 3.3 x 10 6 erg/cm 3 has been obtained in the amorphous SmCo films by applying a magnetic field in the film plane during deposition. It was found that the in-the-film-plane anisotropy depended essentially on the applied field and Sm concentration. For films not synthesized through thermallized sputtering, the easy axis of the film could reoriented. A perpendicular anisotropy was also presented in the film synthesized through thermallized sputtering deposition. A large in-plane anisotropy was obtained in films deposited above ambient temperatures. It was concluded that the surface induced short range ordering was the origin of the in-the-film-phase anisotropy observed in amorphous film deposited in the presence of a magnetic field. The formation mechanism was different from that of the short range ordering induced by field annealing. The perpendicular anisotropy was shown to be growth induced. Large in-plane anisotropy in amorphous films was resulted form partial crystallization in the film. Both the formation of growth induced structure and partial crystallization in the film prevented the formation of the pair ordering and decreased in-the-film-plane anisotropy

  1. Riesgo de tromboembolismo venoso en mujeres consumidoras de anticonceptivos hormonales combinados

    OpenAIRE

    Nápoles Méndez, Danilo; Couto Núñez, Dayana

    2016-01-01

    Desde la introducción en los años 60 de las tabletas anticonceptivas, se han ido produciendo modificaciones en sus componentes, con el objetivo de mejorar su seguridad y tolerancia sin perder su eficacia. Las principales novedades están relacionadas con la introducción de nuevos progestágenos con menores efectos secundarios y mayores beneficios adicionales, así como también con la aparición de un preparado con estrógeno natural y la utilización de nuevas pautas de inicio y de régimen de inter...

  2. Aplicación del método de factores combinados a la conservación de frutillas : características textuales

    OpenAIRE

    Vidales, Susana Leontina

    1997-01-01

    El objetivo de esta Tesis fue el estudio de las características texturales de frutillas mínimamente procesadas. Las frutas fueron preservadas por aplicación de la tecnología de factores combinados. Los obstáculos utilizados incluyen: una leve disminución de la actividad de agua (aw) dentro del rango de valores 0,93-0,97, el control de pH (≈ 3,0-3,1) y la adición de preservativos y agentes antimicrobianos (sorbato de potasio, 1000 ppm; ácido ascórbico, 400 ppm; bisulfito de sodio, 150 ppm) y u...

  3. Mixed Messages from Garnet Lu-Hf and Sm-Nd Geochronology

    Science.gov (United States)

    Vervoort, J. D.; Wang, D.; Johnson, T. A.

    2017-12-01

    Garnet geochronology provides important information on the timing and conditions of metamorphism. As a major indicator mineral formed during metamorphism, its direct dating can not only help establish the timing of metamorphism, provide the "t" for P-T-t paths, but also, if the dated garnet can be placed in a textural context, can provide information on the timing of deformational features. With advances in chemistry and mass spectrometry, garnet Lu-Hf and Sm-Nd geochronology has become an important geochronological tool and we can now reliably (if not routinely) date a wide variety of garnet compositions formed under diverse conditions. In the course of dating a variety of lithologies using both Lu-Hf and Sm-Nd isotope systems, however, some intriguing results have emerged. Although there are many examples where the Lu-Hf and Sm-Nd systems give the same date within uncertainty, there are also many cases where these systems yield significantly different dates, and the differences between these dates can be considerable—many 10's of Ma of and even 100's of Ma. For example, in garnet-bearing Mesoproterozoic gneisses from across the Blue Ridge Province in Virginia, both Lu-Hf and Sm-Nd analyses (determined on the same solutions) define narrow time spans, but with the Sm-Nd dates systematically younger (for orthogneisses Lu-Hf dates are 1032 to 1019 Ma whereas Sm-Nd dates are 965 to 949 Ma—a difference of 67 to 80 Ma). There are many other examples of systematically younger Sm-Nd garnet dates in both the literature and with our ongoing research. Potential explanations for these differences include: 1) strong partitioning of Lu into garnet during growth yielding ages weighted toward the beginning of growth; 2) faster Lu diffusion from high Lu regions after garnet formation, potentially leading to isochron rotation and anomalously old Lu-Hf dates; and 3) differences in closure temperatures of the two isotope systems. We will review several examples of divergent Lu

  4. Crystal growth of Sm0.3Tb0.7FeO3 and spin reorientation transition in Sm1−xTbxFeO3 orthoferrite

    International Nuclear Information System (INIS)

    Wu, Anhua; Wang, Bo; Zhao, Xiangyang; Xie, Tao; Man, Peiwen; Su, Liangbi; Kalashnikova, A.M.; Pisarev, R.V.

    2017-01-01

    In this work, Sm 0.3 Tb 0.7 FeO 3 single crystal was successfully grown by optical floating zone method. Sm 0.3 Tb 0.7 FeO 3 samples with a-, b-, and c-orientation were manufactured by means of Laue photograph. Magnetic properties of Sm 0.3 Tb 0.7 FeO 3 single crystals are studied over a wide temperature range from 2 to 400 K. Spin reorientation transition from Γ 2 to Γ 4 are observed by means of the temperature dependence of magnetization It indicated the reorientation transition temperature of Sm 1−x Tb x FeO 3 single crystals is lowered with the contents of Tb contents rising based on this work and our previous works, thus the spin reorientation transition temperature can be adjusted through changing the compound in orthoferrites materials, which means that we can get orthoferrites single crystals with high magnetism property in various temperature through material design. - Highlights: • Sm 0.3 Tb 0.7 FeO 3 single crystals with various compounds were successfully grown by optical floating zone method. • The relation between SRT temperature and composition in Sm 1−x Tb x FeO 3 orthoferrite was indicated. • The spin reorientation transition temperature of Sm 1−x Tb x FeO 3 single crystals can be adjusted through changing the compound in orthoferrites materials.

  5. Low temperature features of the local structure of Sm1-xYxS

    International Nuclear Information System (INIS)

    Menushenkov, A. P.; Chernikov, R. V.; Sidorov, V. V.; Klementiev, K. V.; Alekseev, P. A.; Rybina, A. V.

    2007-01-01

    The particular features of the local electronic and local crystal structures of the mixed-valence compound Sm 1-x Y x S are studied by the XAFS spectroscopy methods in the temperature range 20-300 K for the yttrium concentration x = 0.17, 0.25, 0.33, and 0.45. The temperature behavior of the valence of Sm, as well as of the lengths and the Debye-Waller factors of the bonds Sm-S, Sm-Sm(Y), Y-S, and Y-Sm(Y), has been determined. The violation of the Vegard law has been observed. A model for the estimation of the energy width of the 4f level and of its position with respect to the Fermi level is proposed

  6. Efectos de la suplementación de omega-3 y entrenamiento de intervalos de alta intensidad en el rendimiento físico, presión arterial y composición corporal en individuos sedentarios con sobrepeso

    OpenAIRE

    Peñailillo Escarate, Luis; Mackay Phillips, Karen; Serrano Duarte, Natalia; Canales Espinoza, Pablo; Miranda Herrera, Pamela; Zbinden-Foncea, Hermann

    2016-01-01

    Introducción: el entrenamiento de intervalos de alta intensidad (HIIT) y el consumo de ácidos grasos omega-3 (O3) ha demostrado cada uno por separado aumentar la capacidad aeróbica, el metabolismo oxidativo y la función cardiovascular. Objetivo: examinar el efecto combinado de HIIT más suplementación de O3 en el rendimiento físico, presión arterial y composición corporal en jóvenes sedentarios. Métodos: 28 jóvenes sedentarios con sobrepeso (edad = 22 ± 4 años; IMC = 25,8 ± 2,4 kg·m-2) fueron ...

  7. Conceptual Design Plan SM-43 Replacement Project

    Energy Technology Data Exchange (ETDEWEB)

    University of California, Los Alamos National Laboratory, SCC Project Office

    2000-11-01

    The Los Alamos National Laboratory Conceptual Design Plan for the SM-43 Replacement Project outlines plans for replacing the SM-43 Administration Building. Topics include the reasons that replacement is considered a necessity; the roles of the various project sponsors; and descriptions of the proposed site and facilities. Also covered in this proposal is preliminary information on the project schedule, cost estimates, acquisition strategy, risk assessment, NEPA strategy, safety strategy, and safeguards and security. Spreadsheets provide further detail on space requirements, project schedules, and cost estimates.

  8. Color tunability of Sm{sup 3+} doped antimony–phosphate glass phosphors showing broadband fluorescence

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, P. [School of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034 (China); Zhang, J.J., E-mail: zhangjj@dlpu.edu.cn [School of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034 (China); Shen, L.F. [Department of Electronic Engineering and State Key Laboratory of Millimeter Waves, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (China); Wang, Z.Q. [School of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034 (China); Pun, E.Y.B. [Department of Electronic Engineering and State Key Laboratory of Millimeter Waves, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (China); Lin, H., E-mail: lhai8686@yahoo.com [School of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034 (China); Department of Electronic Engineering and State Key Laboratory of Millimeter Waves, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (China)

    2016-10-15

    Sm{sup 3+} doped multicomponent antimony phosphate (MSP) luminescent glasses were prepared and tunable white fluorescence has been investigated. Broad visible emission depending on excitation wavelength is validated to be dominated by discrepant Sb{sup 3+} emitting centers. Group of narrow emissions from Sm{sup 3+} is beneficial to adding yellow and red components in Sm{sup 3+} doped MSP glasses, which is strengthened by effective energy transfer from Sb{sup 3+} to Sm{sup 3+}. Excitation wavelength selection and Sm{sup 3+} concentration adjustment are two feasible routes to optimize luminescence color in Sm{sup 3+} doped MSP glasses and the color tunability of fluorescence indicates that amorphous Sm{sup 3+} doped MSP glass phosphors possess potential for ideal white light devices.

  9. Structural and magnetic properties of Fe{sub 2-x}CoSm{sub x}O{sub 4}-nanoparticles and Fe{sub 2-x}CoSm{sub x}O{sub 4}-PDMS magnetoelastomers as a function of Sm content

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz, Mariano M.; Mietta, Jose L.; Soledad Antonel, P. [Instituto de Quimica Fisica de Materiales, Ambiente y Energia (INQUIMAE), Departamento de Quimica Inorganica, Analitica y Quimica Fisica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Av. Cantilo s/n (1428), Buenos Aires (Argentina); Perez, Oscar E. [Departamento de Industrias, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Av. Cantilo s/n (1428), Buenos Aires (Argentina); Martin Negri, R. [Instituto de Quimica Fisica de Materiales, Ambiente y Energia (INQUIMAE), Departamento de Quimica Inorganica, Analitica y Quimica Fisica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Av. Cantilo s/n (1428), Buenos Aires (Argentina); Jorge, Guillermo, E-mail: gjorge@df.uba.ar [Instituto de Fisica de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Av. Cantilo s/n (1428), Buenos Aires (Argentina); Instituto de Ciencias, Universidad Nacional de General Sarmiento, J.M. Gutierrez 1150 (1613), Los Polvorines, Buenos Aires (Argentina)

    2013-02-15

    We have synthesized magnetic Fe{sub 2-x}CoSm{sub x}O{sub 4} nanoparticles (NPs) by means of the coprecipitation method, varying Sm content from x=0 to x=0.5. Energy-dispersive X-ray spectroscopy showed agreement between the metal proportion of the obtained nanoparticles and the stoichiometric mixture of cations used for the synthesis. Part of the particles were heated at 800 Degree-Sign C, and both were characterized by X-ray diffraction, scanning electron microscope imaging and magnetization measurements. Physical and magnetic properties were analyzed as a function of Sm content, before and after the heating treatment. A phase segregation is found for the calcined nanoparticles with large Sm content. The magnetic remanence, saturation and coercive field were investigated as a function of Sm content for both heated and unheated (as-prepared) particles. Polydimethylsiloxane-NPs magnetoelastomers were prepared and cured under an external uniform magnetic field, obtaining structured anisotropic composites, in which inorganic needles (columnar micrometric structures) oriented in the direction of the magnetic field are formed. Young modulus and remanent magnetic moment were measured and magnetization time relaxation experiments were performed in the directions parallel and perpendicular to the needles in order to determine the magnetic and elastic anisotropy of the composites. The elastic modulus measured parallel to the needles resulted almost twice in magnitude with respect to the perpendicular modulus. The measured magnetic anisotropy of the composites is probably due to the enhanced interparticle interaction within a needle and the freezing of an preferred easy axis distribution among the particles at the curing process. - Highlights: Black-Right-Pointing-Pointer We study magnetic and physical properties of Sm-substituted Fe{sub 2}CoO{sub 4} nanoparticles. Black-Right-Pointing-Pointer Magnetic nanoparticles were synthesized by the coprecipitation method. Black

  10. The effect of Sm-doping on optical properties of LaB6 nanoparticles

    International Nuclear Information System (INIS)

    Chao, Luomeng; Bao, Lihong; Shi, Junjie; Wei, Wei; Tegus, O.; Zhang, Zhidong

    2015-01-01

    Highlights: • Nanoparticles of Sm-doped LaB 6 have been prepared by solid state reaction. • All samples exhibit high absorbance in NIR range and UV range. • The increase of Sm-doping amount shifts the position of minimum absorptance value. • The optical properties of Sm-doped LaB 6 were interpreted by DFT theory. - Abstract: Nanocrystalline particles of LaB 6 , SmB 6 and Sm-doped LaB 6 have been prepared by a solid-state reaction in order to investigate the optical properties of ternary rare-earth hexaborides. The sizes of prepared nanoparticles range from dozens to more than 200 nm, as confirmed by XRD, SEM and TEM examinations. The optical property concerning the absorption spectra was tested with ultraviolet-visible-near infrared (UV-vis-NIR) absorption spectrum. All samples exhibit high absorbance in NIR range and UV range. The increase of Sm-doping amount shifts the position of minimum absorptance value of LaB 6 to the long-wave direction. Density functional theory (DFT) is employed to interpret the optical properties of Sm-doped LaB 6 , and results indicate that Sm 4f states change the DOS at near Fermi surface of LaB 6 after Sm doping and the reduced number of conduction electrons results into the change of absorption spectra

  11. Electrospinning fabrication and luminescent properties of SrMoO4:Sm3+ nanofibers

    International Nuclear Information System (INIS)

    Du Pingfan; Song Lixin; Xiong Jie; Cao Houbao; Xi Zhenqiang; Guo Shaoyi; Wang Naiyan; Chen Jianjun

    2012-01-01

    Highlights: ► SrMoO 4 :Sm 3+ fluorescent nanofibers were fabricated by electrospinning. ► The properties of the SrMoO 4 :Sm 3+ nanofibers were investigated. ► The obtained nanofibers exhibit a fine orange-red fluorescent property. ► The PL intensity of the nanofibers is superior to the nanoparticles counterpart. ► The optimum doping concentration of Sm 3+ in the host lattice is 2 at.%. - Abstract: Samarium ions doped strontium molybdate (SrMoO 4 :Sm 3+ ) nanofibers (NFs) were fabricated by a simple electrospinning process. The obtained SrMoO 4 :Sm 3+ NFs are composed of scheelite-type tetragonal SrMoO 4 phase, and the NFs have an average diameter of ca. 90 nm. Under 275 nm ultraviolet (UV) excitation, the NFs show an orange-red fluorescent property symbolized by a characteristic emission (606 nm) resulting from the 4 G 5/2 → 6 H 7/2 energy level transition of Sm 3+ . And the photoluminescence (PL) emissi on intensity of the SrMoO 4 :Sm 3+ NFs is superior to that of the nanoparticles (NPs) counterpart under the same doping concentrations. The effect of Sm 3+ concentrations on the 4 G 5/2 → 6 H 7/2 emission intensity was also investigated. The result reveals that the concentration quenching will occur when the Sm 3+ content exceeds 2 at.%. In other words, the SrMoO 4 :Sm 3+ NFs have an optimal luminescent performance under such a doping concentration.

  12. Surface coating and magnetic properties of Sm2Fe17Nx materials

    International Nuclear Information System (INIS)

    Noguchi, K.; Machida, K.; Nishimura, M.; Adachi, G.

    1998-01-01

    Surface coating for finely ground Sm 2 Fe 17 N x (x=-3) powders (diameter 2 Fe 17 N x and (Zn,In)/Cu/Sm 2 Fe 17 N x , showed good oxidation-resistivity and thermal stability compared with the samples prepared without the Cu metal pre-coating, Zn/Sm 2 Fe 17 N x . The epoxy resin- or In metal-bonded magnets produced from the above coated powders, Zn/Cu/Sm 2 Fe 17 N x and (Zn,In)/Cu/Sm 2 Fe 17 N x , under warm molding conditions provided a flux loss of around -15% after standing in air at 120 C for 1000 h, but 30-40% for the conventional injection-type resin-bonded magnets prepared from Nd-Fe-B powders. (orig.)

  13. Riesgo de tromboembolismo venoso en mujeres consumidoras de anticonceptivos hormonales combinados

    Directory of Open Access Journals (Sweden)

    Danilo Nápoles Méndez

    Full Text Available Desde la introducción en los años 60 de las tabletas anticonceptivas, se han ido produciendo modificaciones en sus componentes, con el objetivo de mejorar su seguridad y tolerancia sin perder su eficacia. Las principales novedades están relacionadas con la introducción de nuevos progestágenos con menores efectos secundarios y mayores beneficios adicionales, así como también con la aparición de un preparado con estrógeno natural y la utilización de nuevas pautas de inicio y de régimen de intervalo libre de hormona. Teniendo en cuenta lo anterior se realizó una actualización sobre el riesgo de tromboembolismo venoso en quienes lo consumen estos medicamentos

  14. Transcription Factor SmWRKY1 Positively Promotes the Biosynthesis of Tanshinones in Salvia miltiorrhiza

    Directory of Open Access Journals (Sweden)

    Wenzhi Cao

    2018-04-01

    Full Text Available Tanshinones, one group of bioactive diterpenes, were widely used in the treatment of cardiovascular diseases. WRKYs play important roles in plant metabolism, but their regulation mechanism in Salvia miltiorrhiza remains elusive. In this study, one WRKY transcription factor SmWRKY1 was isolated and functionally characterized from S. miltiorrhiza. Multiple sequence alignment and phylogenetic tree analysis showed SmWRKY1 shared high homology with other plant WRKYs such as CrWRKY1. SmWRKY1 was found predominantly expressed in leaves and stems, and was responsive to salicylic acid (SA, methyl jasmonate (MeJA, and nitric oxide (NO treatment. Subcellular localization analysis found that SmWRKY1 was localized in the nucleus. Over-expression of SmWRKY1 significantly elevated the transcripts of genes coding for enzymes in the MEP pathway especially 1-deoxy-D-xylulose-5-phosphate synthase (SmDXS and 1-deoxy-D-xylulose-5-phosphate reductoisomerase (SmDXR, resulted in over fivefold increase in tanshinones production in transgenic lines (up to 13.7 mg/g DW compared with the control lines. A dual-luciferase (Dual-LUC assay showed that SmWRKY1 can positively regulate SmDXR expression by binding to its promoter. Our work revealed that SmWRKY1 participated in the regulation of tanshinones biosynthesis and acted as a positive regulator through activating SmDXR in the MEP pathway, thus provided a new insight to further explore the regulation mechanism of tanshinones biosynthesis.

  15. Uso de las Nuevas Tecnologías de la Información y Comunicación para la Enseñanza de las Matemáticas a Alumnos con Minusvalía Visual

    Directory of Open Access Journals (Sweden)

    José Eduardo Badilla Mora

    2011-05-01

    Full Text Available En este artículo se pretende llevar a cabo una presentación de las herramientas tecnológicas que podemos utilizar en nuestra labor docente cotidiana como elemento integrador de aquellos alumnos que poseen minusvalía visual, de modo que como profesionales podamos atender la necesidad educativa de éstos, a la vez que garantizamos un apropiado aprendizaje de los contenidosmatemáticos establecidos por el currículo. Se presentará de manera explícita el abordaje de aquellos contenidos que involucran representaciones gráficas, tales como los relacionados con la estadística, geometría, funciones o trigonometría. Se expone información sobre el uso del software Quick Tac 4.0 versión beta combinado con Quick Tac 3.1, Math Trax, Vozme, y la impresión de documento en braille mediante las máquinas de impresión Juliet Pro 60, o Book Maker entre otras.

  16. Investigation of the oxidative processes in intermetallic Sm Co5 powder during heat treatment

    International Nuclear Information System (INIS)

    Talijan, Nadezda M.; Milutinovic-Nikolic, Aleksandra; Stajic-Trosic, Jasna T.; Jovanovic, Zarko D.

    1996-01-01

    Understanding of the thermal stability of intermetallic Sm Co 5 powder is essential for designing the working atmosphere in all phases of the technological procedure in the production of sintered Sm Co 5 magnets to obtain maximal magnetic properties. The thermal stability of the Sm Co 5 powder with defined chemical composition and particle size was investigated in the interval from 20 to 900 deg C. Commercial Sm Co 5 powder was used in this experiment. The powder was milled in anhydrous toluene in an agate mortar to fine powder of quality used in the production of sintered magnets. All the experiments were carried out with powder of an average particle size of 7.23μm, established by SEM. THe thermal stability of the Sm Co 5 powder in static air atmosphere was investigated by thermogravimetric analysis (TGA) using a DuPont Thermal Analyzer. Investigation of the behaviour of Sm Co 5 powder during heating was carried out using new samples of Sm Co 5 powder for each of the investigated temperature cycles. It was found by TGA that up to 200 deg C, the oxidation of Sm Co 5 was negligible. X-ray diffraction of the thermogravimetric experimental residue of the Sm Co 5 powder, heated at 240 deg C, yielded only the presence of the Sm Co 5 phase. By X-ray diffraction different crystal forms were identified depending on the maximal heating temperature. The following phases were identified: Sm 2 O 3 , Co, Co O, Co 3 O 4 and Sm Co O 3 . According to TG and X-ray results, for each of the investigated temperatures, the corresponding chemical reactions were established. The experimental data from both the thermal and X-ray investigations confirm that the phases of pressing and aligning the Sm Co 5 powder, in the process of producing sintered Sm Co 5 magnets, may be performed without a protective atmosphere. (author)

  17. The biodistribution and kinetics of the 153Sm labelled avidin, streptavidin and biotin

    International Nuclear Information System (INIS)

    Li Guiping; Zhu Chengmo; Jiang Xufeng; Feng Guowei; Zhang Shengguo

    1999-01-01

    Due to the high affinity of biotin to Av or SA. The authors labelled a biotin derivative (DTPA-biotin) with 153 Sm and then bound this 153 Sm labelled DTPA-biotin to Av or SA. The in vivo kinetics and biodistribution of 153 Sm labelled Av, SA and DTPA-biotin were studied in the rat and mice. The results demonstrated that 153 Sm-Av cleared from the blood rapidly with high liver and renal uptake; 153 Sm-SA cleared from blood slowly with high retention in liver, spleen and kidney, whereas 153 Sm metabolize more fast, and excreted mainly through the kidney. Thereby, the biodistribution difference of SA and Av mentioned above provided an experimental basis for the selection of different components of A-V system in pre-targeting radio-immuno imaging and radioimmunotherapy

  18. Características del trastorno por déficit de atención e hiperactividad en escolares mexicanos de acuerdo con la percepción de los padres

    Directory of Open Access Journals (Sweden)

    Omar Barrios

    2016-07-01

    Full Text Available El trastorno por déficit de atención e hiperactividad (TDAH es uno de los trastornos del neurodesarrollo que más se detectan en la infancia. El objetivo del presente estudio fue estimar la prevalencia del TDAH en una muestra de niños mexicanos de edad escolar. Se estudiaron 6639 alumnos de escuelas públicas de Guadalajara, Jalisco, México, a los que se les levantó una encuesta con el informe de los padres en un cuestionario diseñado bajo los criterios que el DSM-IV considera para el diagnóstico de TDAH. Se recuperaron y analizaron 4399 cuestionarios. De acuerdo con el informe de los padres, el 8.9% de los niños tienen un perfil de conductas compatibles con los criterios del DSM-IV para el diagnóstico de TDAH. La proporción masculino:femenino fue de 2:1. La distribución por subtipos fue: 147 escolares con tipo combinado, 132 inatento y 114 del tipo hiperactivo-impulsivo. La prevalencia fue mayor del primero al tercer grado que del cuarto al sexto. La prevalencia de TDAH calculada se encuentra dentro del rango informado en otros países. Los estudios realizados en grandes muestras son útiles para diseñar estrategias de intervención acordes a la población en cuestión.

  19. The microwave absorbing properties of SmCo attached single wall carbon nanotube/epoxy composites

    International Nuclear Information System (INIS)

    Yu, Liming; Li, Bo; Sheng, Leimei; An, Kang; Zhao, Xinluo

    2013-01-01

    Highlights: •The SmCo nanoparticles attached SWCNTs were prepared by dc arc discharge method. •The nano-composite prepared by a rare earth permanent magnet Sm 2 Co 17 as catalyst. •The SmCo attached SWCNT/epoxy composites have an excellent electromagnetic matching characteristics. •The reflection loss and bandwidth below −20 dB of the composite can reach −23.7 dB, 6.2 GHz, respectively. -- Abstract: The SmCo nanoparticles attached single wall carbon nanotubes (SmCo attached SWCNTs) were prepared by hydrogen dc arc discharge method using 2:17 type SmCo permanent powder as catalyst. The SmCo attached SWCNT/epoxy composites with different doping ratios were investigated in the frequency region of 2–18 GHz. The complex permittivity and permeability of the SmCo attached SWCNT/epoxy composites were calculated. The reflection loss properties were simulated by transmission line theory and the microwave absorptive mechanisms were discussed. The results indicate that, due to the better interfacial polarization absorption mechanism of SmCo attached SWCNTs and the electromagnetic (EM) matching of magnetic loss and dielectric loss, the microwave absorption properties of SmCo attached SWCNT/epoxy are evidently improved. When the SmCo attached SWCNTs is doped by 1 wt%, the composite display a larger and wider absorption peak, and the bandwidth of the reflection loss below −20 dB is larger than 6 GHz with the thickness of 3.3 mm. It is expected that the new SmCo attached SWCNT/epoxy composites will be a good microwave absorbing material for the applications in X band, Ku band, or even K band

  20. Sm 3+-doped polymer optical waveguide amplifiers

    Science.gov (United States)

    Huang, Lihui; Tsang, Kwokchu; Pun, Edwin Yue-Bun; Xu, Shiqing

    2010-04-01

    Trivalent samarium ion (Sm 3+) doped SU8 polymer materials were synthesized and characterized. Intense red emission at 645 nm was observed under UV laser light excitation. Spectroscopic investigations show that the doped materials are suitable for realizing planar optical waveguide amplifiers. About 100 μm wide multimode Sm 3+-doped SU8 channel waveguides were fabricated using a simple UV exposure process. At 250 mW, 351 nm UV pump power, a signal enhancement of ˜7.4 dB at 645 nm was obtained for a 15 mm long channel waveguide.

  1. Germinal Center Kinases SmKIN3 and SmKIN24 Are Associated with the Sordaria macrospora Striatin-Interacting Phosphatase and Kinase (STRIPAK) Complex.

    Science.gov (United States)

    Frey, Stefan; Reschka, Eva J; Pöggeler, Stefanie

    2015-01-01

    The striatin-interacting phosphatase and kinase (STRIPAK) complex is composed of striatin, protein phosphatase PP2A and protein kinases that regulate development in animals and fungi. In the filamentous ascomycete Sordaria macrospora, it is required for fruiting-body development and cell fusion. Here, we report on the presence and function of STRIPAK-associated kinases in ascomycetes. Using the mammalian germinal center kinases (GCKs) MST4, STK24, STK25 and MINK1 as query, we identified the two putative homologs SmKIN3 and SmKIN24 in S. macrospora. A BLASTP search revealed that both kinases are conserved among filamentous ascomycetes. The physical interaction of the striatin homolog PRO11 with SmKIN3 and SmKIN24 were verified by yeast two-hybrid (Y2H) interaction studies and for SmKIN3 by co-Immunoprecipitation (co-IP). In vivo localization found that both kinases were present at the septa and deletion of both Smkin3 and Smkin24 led to abnormal septum distribution. While deletion of Smkin3 caused larger distances between adjacent septa and increased aerial hyphae, deletion of Smkin24 led to closer spacing of septa and to sterility. Although phenotypically distinct, both kinases appear to function independently because the double-knockout strain ΔSmkin3/ΔSmkin24 displayed the combined phenotypes of each single-deletion strain.

  2. Germinal Center Kinases SmKIN3 and SmKIN24 Are Associated with the Sordaria macrospora Striatin-Interacting Phosphatase and Kinase (STRIPAK Complex.

    Directory of Open Access Journals (Sweden)

    Stefan Frey

    Full Text Available The striatin-interacting phosphatase and kinase (STRIPAK complex is composed of striatin, protein phosphatase PP2A and protein kinases that regulate development in animals and fungi. In the filamentous ascomycete Sordaria macrospora, it is required for fruiting-body development and cell fusion. Here, we report on the presence and function of STRIPAK-associated kinases in ascomycetes. Using the mammalian germinal center kinases (GCKs MST4, STK24, STK25 and MINK1 as query, we identified the two putative homologs SmKIN3 and SmKIN24 in S. macrospora. A BLASTP search revealed that both kinases are conserved among filamentous ascomycetes. The physical interaction of the striatin homolog PRO11 with SmKIN3 and SmKIN24 were verified by yeast two-hybrid (Y2H interaction studies and for SmKIN3 by co-Immunoprecipitation (co-IP. In vivo localization found that both kinases were present at the septa and deletion of both Smkin3 and Smkin24 led to abnormal septum distribution. While deletion of Smkin3 caused larger distances between adjacent septa and increased aerial hyphae, deletion of Smkin24 led to closer spacing of septa and to sterility. Although phenotypically distinct, both kinases appear to function independently because the double-knockout strain ΔSmkin3/ΔSmkin24 displayed the combined phenotypes of each single-deletion strain.

  3. Interaction mode between methylene blue-Sm(III) complex and ...

    African Journals Online (AJOL)

    Spectroscopic and viscosity methods were applied to investigate the interaction between methylene blue (MB)-Sm(III) complex and herring sperm DNA by using acridine orange as a spectral probe in Tris-HCl buffer (pH 7.40). By means of molar ratio method, the binding ratios between MB-Sm(III)and DNA were determined ...

  4. Coilin phosphorylation mediates interaction with SMN and SmB′

    Science.gov (United States)

    Toyota, Cory G.; Davis, Misty D.; Cosman, Angela M.; Hebert, Michael D.

    2010-01-01

    Cajal bodies (CBs) are subnuclear domains that participate in spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesis and play a part in the assembly of the spliceosomal complex. The CB marker protein, coilin, interacts with survival of motor neuron (SMN) and Sm proteins. Several coilin phosphoresidues have been identified by mass spectrometric analysis. Phosphorylation of coilin affects its self-interaction and localization in the nucleus. We hypothesize that coilin phosphorylation also impacts its binding to SMN and Sm proteins. In vitro binding studies with a C-terminal fragment of coilin and corresponding phosphomimics show that SMN binds preferentially to dephosphorylated analogs and that SmB′ binds preferentially to phosphomimetic constructs. Bacterially expressed full-length coilin binds more SMN and SmB′ than does the C-terminal fragment. Co-immunoprecipitation and phosphatase experiments show that SMN also binds dephosphorylated coilin in vivo. These data show that phosphorylation of coilin influences interaction with its target proteins and, thus, may be significant in managing the flow of snRNPs through the CB. PMID:19997741

  5. Coilin phosphorylation mediates interaction with SMN and SmB'.

    Science.gov (United States)

    Toyota, Cory G; Davis, Misty D; Cosman, Angela M; Hebert, Michael D

    2010-04-01

    Cajal bodies (CBs) are subnuclear domains that participate in spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesis and play a part in the assembly of the spliceosomal complex. The CB marker protein, coilin, interacts with survival of motor neuron (SMN) and Sm proteins. Several coilin phosphoresidues have been identified by mass spectrometric analysis. Phosphorylation of coilin affects its self-interaction and localization in the nucleus. We hypothesize that coilin phosphorylation also impacts its binding to SMN and Sm proteins. In vitro binding studies with a C-terminal fragment of coilin and corresponding phosphomimics show that SMN binds preferentially to dephosphorylated analogs and that SmB' binds preferentially to phosphomimetic constructs. Bacterially expressed full-length coilin binds more SMN and SmB' than does the C-terminal fragment. Co-immunoprecipitation and phosphatase experiments show that SMN also binds dephosphorylated coilin in vivo. These data show that phosphorylation of coilin influences interaction with its target proteins and, thus, may be significant in managing the flow of snRNPs through the CB.

  6. Origen étnico y estructura genética de tres poblaciones colombianas con ascendencia africana: estudio combinado de microsatélites y marcadores bialélicos del cromosoma Y

    Directory of Open Access Journals (Sweden)

    Julián Oliverio Mora Oberlaender

    2004-07-01

    África occidental y central, acorde con los datos históricos acerca de la procedencia de los esclavos traídos a América durante los siglos XVI-XIX. Tanto para marcadores bialélicos como microsatelitales, se observó una cercanía de Palenque con poblaciones nativas de Gambia, y de Quibdó con otros grupos del norte de Camerún, de afiliación Bantú.

  7. Dilatometric and dielectric behaviour of Sm modified PCT ceramics

    International Nuclear Information System (INIS)

    Singh, Sarabjit; Thakur, O.P.; Prakash, Chandra; Raina, K.K.

    2005-01-01

    Samarium modified PCT ceramics with composition (Pb 0.76-x Sm x Ca 0.24 )(Ti 0.98 Mn 0.02 )O 3 ; x=0-0.08 in steps of 0.02 were prepared by conventional mixed-oxide method. Detailed dilatometric studies were carried out for green specimens in order to study sintering behaviour. Change in the dilatometric behaviour is correlated with the XRD results of powders calcined at different temperatures. Dielectric constant was observed to increase with increasing Sm concentration, which has been attributed to reduced tetragonality and better densification on Sm substitution. SEM micrographs have revealed the grain size of the samples. Ferroelectric hysteresis behaviour was studied for all the compositions

  8. Angle-resolved photoemission investigation of SmB{sub 6}

    Energy Technology Data Exchange (ETDEWEB)

    Hlawenka, Peter; Rader, Oliver; Siemensmeyer, Konrad; Weschke, Eugen; Varykhalov, Andrei; Rienks, Emile [Helmholtz-Zentrum Berlin (Germany); Shitsevalova, Natalya [Institute for Problems of Material Science, Kiev (Ukraine); Gabani, Slavomir; Flachbart, Karol [IEP, Slovak Academy of Science, Kosice (Slovakia)

    2015-07-01

    Recently the mixed valence compound SmB{sub 6} has drawn great attention. Theoretically predicted surface states, which should result from a hybridisation of localised f-bands with conduction electrons and a band inversion, would make SmB{sub 6} the first realisation of a so called topological Kondo insulator. Conductivity and transport measurements, as well as spin-resolved photoemission spectroscopy seem to fortify the scenario of a topological nature of the conductive surface. We investigate the surface electronic structure of SmB{sub 6} by means of high resolution angle-resolved photoemission spectroscopy measurements below 1 K. We will present new insights into the surface states that determine the low temperature conductivity of this material.

  9. Labelling of MoAb with 153SmH1ETA: Preliminary results

    International Nuclear Information System (INIS)

    Ferro-Flores, G.; De, F.; Ramirez, M.; Pedraza-Lopez, M.; Tendilla, J.I.; Melendez-Alafort, L.; Murphy, C.A.

    2001-01-01

    A method to label MoAb with Sm-153 using 1,5,9,13-tetraazacyclohexadecane N,N',N'',N''' tetraacetic acid (H 4 ETA) as a bifunctional chelator was developed. H 4 ETA and SmH 1 ETA were synthesized in our laboratory and characterized by IR spectroscopy, TGA (thermogravimetric analysis), SEM (Scattering Electronic Microscopy), EDAX (Elemental Dispersion Analysis by X-rays) and EPR (Electron Paramagnetic Resonance) at 6 K. The 153 SmH 1 ETAMoAb was prepared by a simple incubation of the MoAb ior cea1, and the 153 SmH 1 ETA complex at neutral pH and at room temperature for 24 h. The specific activity of the labelled antibody was 111 MBq/mg (3 mCi/mg). Sm-153(III) is commercially available with specific activities up to 318.2 GBq/mg. Therefore, under the conditions described above 153 SmH 1 ETA labelled MoAb could be obtained with specific activity up to 1.14 GBq/mg (30.7 mCi/mg). (author)

  10. Symmetries for SM Alignment in multi-Higgs Doublet Models

    CERN Document Server

    Pilaftsis, Apostolos

    2016-01-01

    We derive the complete set of maximal symmetries for Standard Model (SM) alignment that may occur in the tree-level scalar potential of multi-Higgs Doublet Models, with $n > 2$ Higgs doublets. Our results generalize the symmetries of SM alignment, without decoupling of large mass scales or fine-tuning, previously obtained in the context of two-Higgs Doublet Models.

  11. Colaboración atención primaria-salud mental en la asistencia a pacientes con depresión: evaluación de una experiencia piloto

    OpenAIRE

    Carlos Calderón; Laura Balagué; Álvaro Iruin; Ander Retolaza; Jon Belaunzaran; Javier Basterrechea; Isabel Mosquera

    2016-01-01

    Objetivo: Implementar y evaluar una experiencia colaborativa entre Atención Primaria (AP) y Salud Mental (SM) para mejorar la asistencia a los pacientes con depresión. Diseño: Proyecto colaborativo piloto con enfoque de investigación acción participativa (IAP) durante 2013. Emplazamiento: : País Vasco. Osakidetza (Servicio Vasco de Salud). Bizkaia y Gipuzkoa. Participantes: Doscientos siete profesionales de medicina de familia, enfermería, psiquiatría, enfermería psiquiátrica, psicol...

  12. Development and implementation of an interface control-process and of additional models in the simulator of combined cycle units; Desarrollo e implantacion de una interfaz control-proceso y de modelos adicionales en el simulador de unidades de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Martinez R, Rogelio E; Ramirez G, Miguel; Melgar G, Jose L; Codero C, Juan C; Romero J, Guillermo [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2001-07-01

    In this article are described the design and implementation of an interface control-process and the formulation of the process models for the simulation of the vibration amplitudes of the steam and gas turbines and of the monitoring system of gas discharges, which comprise a simulator of total reach of combined cycle units. These three systems had to be developed and implemented in the simulator of combined cycle units, that the Instituto de Investigaciones Electricas (IIE) developed for the Comision Federal de Electricidad (CFE), with the purpose of solving different problematic caused by the use of a platform of commercial software for the construction of simulators. The problematic presented by the platform of software is briefly described, as well as the solutions contributed with respect to the interconnection of signals control-process, and to the lack of models of the mechanical part of the steam and gas turbines, and of the monitoring system of polluting emissions. [Spanish] En este articulo se describen el diseno e implantacion de una interfaz control-proceso y la formulacion de los modelos de proceso para la simulacion de las amplitudes de vibracion de las turbinas de gas y de vapor y del sistema de monitoreo de emisiones de gases, los cuales forman parte de un simulador de alcance total de unidades de ciclo combinado. Estos tres sistemas tuvieron que ser desarrollados e implementados en el simulador de unidades de ciclo combinado, que el Instituto de Investigaciones electricas (IIE) desarrollo para la Comision Federal de Electricidad (CFE), con el fin de resolver diferentes problematicas ocasionadas por la utilizacion de una plataforma de software comercial para la construccion de simuladores. Se describen brevemente las problematicas presentadas por la plataforma de software, asi como las soluciones aportadas en lo relativo a la interconexion de senales control-proceso, y a la falta de modelos de la parte mecanica de las turbinas de gas y de vapor, y

  13. The constitution of alloys in the Al-rich corner of the Al-Si-Sm ternary system

    International Nuclear Information System (INIS)

    Markoli, B.; Spaic, S.; Zupanic, F.

    2001-01-01

    The constitution of alloys and the liquidus surface in the Al-rich corner of the Al-Si-Sm ternary system were determined by the examination of controlled heated and cooled specimens, as well as heat-treated specimens by means of optical and scanning electron microscopy, energy-dispersive X-ray spectroscopy, differential thermal analysis and X-ray diffraction. The Al-rich corner of the Al-Si-Sm ternary system comprises five regions of primary crystallisation (α Al , β Si , Al 3 Sm, Al 2 Si 2 Sm and AlSiSm) with following characteristic invariant reaction sequences: ternary eutectic reaction L → α Al + β Si + Al 2 Si 2 Sm, and two liquidus transition reactions, i. e., L + Al 3 Sm → α Al + AlSiSm, and L + AlSiSm → α Al + Al 2 Si 2 Sm. Along with the position of ternary eutectic and both interstitial points in the Al-rich corner of the Al-Si-Sm ternary system, the temperatures for each reaction were determined. (orig.)

  14. Facile synthesis of Sm-doped BiFeO{sub 3} nanoparticles for enhanced visible light photocatalytic performance

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Zijun; Chen, Da, E-mail: dchen_80@hotmail.com; Wang, Sen; Zhang, Ning; Qin, Laishun, E-mail: qinlaishun@cjlu.edu.cn; Huang, Yuexiang

    2017-06-15

    Highlights: • Effective Sm doping into BiFeO{sub 3} nanoparticles was obtained by a facile sol-gel route. • Band gap of Sm-doped BiFeO{sub 3} nanoparticles was regulated by the dopant concentration. • Sm-doped BiFeO{sub 3} nanoparticles exhibited superior photocatalytic activities. • The possible photocatalytic mechanism of Sm-doped BiFeO{sub 3} nanospheres was discussed. - Abstract: In this work, the effect of Sm doping on the structural and photocatalytic properties of BiFeO{sub 3} (BFO) was investigated. A series of Sm doped BFO nanoparticles containing different Sm dopant contents (Bi{sub (1−x)}Sm{sub x}FeO{sub 3}, x = 0.00, 0.01, 0.03, 0.05, 0.07, 0.10) were synthesized via a simple sol-gel route. It was revealed that Sm{sup 3+} ions were successfully doped into BFO nanoparticles, and the band gap value was gradually decreased when increasing Sm dopant concentration. The photocatalytic activity of Sm-doped BFO photocatalyst was significantly affected by the Sm doping content. Compared to pure BFO, the Sm-doped BFO samples exhibited much higher photocatalytic activity. The improved photocatalytic activity of Sm-doped BFO could be attributed to the enhanced visible light absorption and the efficient separation of photogenerated electrons and holes derived from Sm dopant trapping level in the Sm-doped BFO samples. In addition, the possible photocatalytic mechanism of Sm-doped BFO photocatalyst was also proposed.

  15. Lifetime measurements of the excited states in {sup 145} Sm

    Energy Technology Data Exchange (ETDEWEB)

    El-Badry, A M; Abdel Samie, Sh; Ahmad, A A [Depatment of Physics, Faculty of Science, ElMinia University, ElMinia, (Egypt); Kuroyanagi, T; Odahara, A; Gono, Y; Morinobu, S [Tandem Accelerator Laboratory, Department of Physics, Kyushu University, (Japan)

    1997-12-31

    Lifetime of the excited levels in {sup 145} Sm has been measured through the {sup 139} La ({sup 10} B, 4 n){sup 145} Sm nuclear reaction. The optimal beam energy of 49 MeV was determined from the measurements of the excitation function and Cascade program. With the possibility of studying lifetime of this nucleus a conventional plunger system have been designed and constructed at kyushu University tandem accelerator laboratory. A La target of 0.22 mg/cm{sup 2} thickness which was evaporated onto a Au foil of 2 mg/cm{sup 2} thickness was used. Since the recoil velocity was estimated to be 1.76 mm/ns (beta 0.00585), the measurable time range resulted in the range from 5 Ps to 5 ns. The single spectra measurements were performed at the 20 plunger positions in the range from 10 {mu} to 10 mm. Analyses of the data were carried using hypermet and/or GF2 program to obtain the lifetimes. A new list of lifetimes for 12 excited states up to 3.922 MeV excitations for {sup 145} Sm were determined for the first time. Decay curves of the these transitions are discussed. The new lifetimes of excited states in {sup 145} Sm enabled us to understand the electromagnetic properties. The deduced transition probabilities were established and compared with that of N = 83 isotones and the closed shell nucleus {sup 144} Sm. In addition, a nuclear structure of {sup 145} Sm have been discussed and proposed in framework of the shell model. 4 figs., 1 tab.

  16. SM*A*S*H (Standard Model*Axion*Seesaw*Higgs portal inflation)

    International Nuclear Information System (INIS)

    Ringwald, Andreas

    2016-10-01

    We present a minimal model for particle physics and cosmology. The Standard Model (SM) particle content is extended by three right-handed SM-singlet neutrinos N_i and a vector-like quark Q, all of them being charged under a global lepton number and Peccei-Quinn (PQ) U(1) symmetry which is spontaneously broken by the vacuum expectation value υ_σ∝10"1"1 GeV of a SM-singlet complex scalar field σ. Five fundamental problems - neutrino oscillations, baryogenesis, dark matter, inflation, strong CP problem - are solved at one stroke in this model, dubbed ''SM*A*S*H'' (Standard Model*Axion*Seesaw*Higgs portal inflation). It can be probed decisively by upcoming cosmic microwave background and axion dark matter experiments.

  17. Tuning the Magnetic Properties and Structural Stabilities of the 2-17-3 Magnets Sm2Fe17X3 (X =C , N) by Substituting La or Ce for Sm

    Science.gov (United States)

    Pandey, Tribhuwan; Du, Mao-Hua; Parker, David S.

    2018-03-01

    Designing a permanent magnet with reduced critical rare-earth content is of paramount importance in the development of cost-effective modern technologies. By performing comprehensive first-principles calculations, we investigate the potential avenues for reducing the critical rare-earth content in Sm2Fe17N3 and Sm2Fe17C3 by making a La or Ce substitution for Sm. The calculated magnetic properties of base compounds are in good agreement with the previous low-temperature (4.2-K) experimental measurements, and they show a large axial anisotropy. Although La or Ce substitution results in a slight reduction of magnetic anisotropy, the magnetic moments of Fe atoms mostly remain unchanged. Specifically, large axial anisotropies of 7.2 and 4.1 MJ /m3 are obtained for SmCeFe17 N3 and SmLaFe17 N3 , respectively. These values of anisotropies are comparable to the state-of-the-art permanent magnet Nd2 Fe14 B . The foremost limitation of Sm2 Fe17X3 magnets for practical application is the formation nitrogen or carbon vacancies at high temperatures. By calculating the N- (C)- vacancy formation energy, we show that La or Ce substitution enhances the vacancy formation energy. This enhanced vacancy formation energy will likely improve the thermodynamic stability of these alloys at high temperatures. Therefore, La- or Ce-substituted Sm2Fe17C3 and Sm2Fe17N3 compounds are promising candidates for high-performance permanent magnets with substantially reduced rare-earth content.

  18. Mastocitosis sistémica con afectación de piel versus mastocitosis indolente

    OpenAIRE

    Tiberio, G.; Berasategui, J.I.; Redondo, M.; Gorraiz, B.; Cascante, L.; García Bragado, F.

    2001-01-01

    El objetivo de trabajo es la presentación de los datos clínicos, analíticos, radiológicos, terapéuticos y de evolución de un caso de matocitosis sistémica (MS) con afectación de piel. Revisando la literatura ya que la mastocitosis sigue siendo una enfermedad de difídicl diagnóstico, sobre todo en los casos que no existen alteraciones cutáneas. We have analyzed the clinical, analytical, radiolodic, therapeutic an evolutive of cases of systemic mastocytosis (SM) skin lesions. The diagnostic ...

  19. EVALUACIÓN DEL MANEJO TUBULAR DEL POTASIO EN PACIENTES CIRRÓTICOS TRATADOS CON COMBINACIÓN DE FUROSEMIDA + ESPIRONOLACTONA

    Directory of Open Access Journals (Sweden)

    Algranati L

    2011-01-01

    Full Text Available Los cirróticos desarrollan hiperaldosteronismo secundario en estadios avanzados de su enfermedad, requiriendo tratamiento con furosemida + espironolactona. El manejo tubular del potasio (K en estos pacientes bajo dicho esquema diurético combinado (antagónico no ha sido aun estudiado, por lo cual decidimos describir el valor de la excreción fraccional (EF de potasio y del gradiente transtubular de potasio (GTTK en esta población bajo dichos diuréticos. Material y Método: Se evaluó prospectivamente la EF de sodio (Na, EFK y GTTK en 18 pacientes (11 hombres, edad promedio 56 años, normokalémicos, cirróticos (Ci compensados estadios Child Pugh A, B y C, MELD medio 22, portadores de filtrado glomerular, sedimento urinario y ecografía renal normales, tratados con furosemida + espironolactona y dieta hiposódica. Grupo control: 10 voluntarios sanos bajo igual dieta (S. Análisis estadístico: Wilcoxon. Resultados: Kalemia (mmol/l: 4 ± 0.5 (Ci vs. 4 ± 0.3 (S, p=NS; EFNa (%: 0.8 ± 0.4 (Ci vs. 0.5 ± 0.3 (S p=NS; EFK (%: 9.1 ±3 (Ci vs. 10±2 (S, p=NS; GGTK: 6 ±2 (Ci vs. 4 ±1 (S, p=0.04. Conclusión: Observamos que en cirróticos tratados con furosemida + espironolactona, existe un incremento significativo de la excreción urinaria de potasio, sólo evidenciable por el GTTK.

  20. Insulino resistencia y síndrome metabólico en pacientes con enfermedad coronaria definida por angiografía Insulin-resistance and metabolic syndrome in patients with coronary heart disease defined by angiography

    Directory of Open Access Journals (Sweden)

    Silvia Benozzi

    2009-04-01

    Full Text Available Se examinó la frecuencia de insulino-resistencia (IR y síndrome metabólico (SM en pacientes coronarios empleando diferentes criterios de definición y se analizó cuáles mostraban mejor asociación con la presencia y gravedad de la afección. Fue un estudio casos-controles en 100 pacientes con edades entre 40 y 70 años que concurrieron a un centro hospitalario para realizarse una angiografía. IR fue definido por insulina >15 mU/l, el modelo hemostático de insulino-resistencia (HOMA-IR >3.1 y la combinación del índice de masa corporal (IMC >27.5 kg/m² con HOMA-IR >3.6. SM fue definido según International Diabetes Federation y American Heart Association / National Heart, Lung, and Blood. Insulina >15 mU/l y HOMA-IR >3.1 tuvieron la misma sensibilidad, (60.3%, y se asociaron significativamente con la extensión de la enfermedad coronaria, p = 0.001 y p = 0.009 respectivamente. En cambio, IMC >27.5 kg/m² con HOMA-IR >3.6 mostró menor sensibilidad, (43.1%, y menor asociación con la gravedad, (p = 0.028. Los odds ratio (OR para enfermedad coronaria fueron respectivamente: 3.16 (IC 95% 1.28-7.79, p = 0.012; 2.93 (IC 95% 1.20-7.19 p = 0.019; 2.86 (IC 95% 1.10-7.41, P = 0.031. La frecuencia de SM definida según American Heart Association / National Heart, Lung, and Blood fue mayor en coronarios versus controles (62.1% versus 33.3%, p = 0.003, se asoció con la enfermedad en uno o en múltiples vasos (p = 0.011 y fue su predictor, OR = 4.22 (IC 95% 1.65-10.83 p = 0.003. Sin embargo, SM definido según International Diabetes Federation no se asoció con la presencia ni con la gravedad de la enfermedad.The frequency of insulin-resistance (IR and metabolic syndrome (MS were examined in coronary patients using different criteria of definition. It was also analyzed which of them indicated a strong association with the presence and severity of the disease. This was a case-control study on 100 patients between 40 and 70 years old, assisted in a

  1. Propagation of Nd magnetic phases in Nd/Sm(001) superlattices

    International Nuclear Information System (INIS)

    Soriano, S; Dufour, C; Dumesnil, K; Stunault, A

    2006-01-01

    The propagation of Nd long range magnetic order in the hexagonal and cubic sublattices has been investigated in double hexagonal compact Nd/Sm(001) superlattices by resonant x-ray magnetic scattering at the Nd L 2 absorption edge. For a superlattice with 3.7 nm thick Sm layers, the magnetic structure of the hexagonal sublattice propagates coherently through several bilayers, whereas the order in the cubic sublattice remains confined to single Nd blocks. For a superlattice with 1.4 nm thick Sm layers, the magnetic structures of both sublattices appear to propagate coherently through the superlattice. This is the first observation (i) of the long range coherent propagation of Nd order on the cubic sites between Nd blocks and (ii) of a different thickness dependence of the propagation of the Nd magnetic phases associated with the hexagonal and cubic sublattices. The propagation of the Nd magnetic order through Sm is interpreted in terms of generalized susceptibility of the Nd conduction electrons

  2. The simultaneous mass and energy evaporation (SM2E) model.

    Science.gov (United States)

    Choudhary, Rehan; Klauda, Jeffery B

    2016-01-01

    In this article, the Simultaneous Mass and Energy Evaporation (SM2E) model is presented. The SM2E model is based on theoretical models for mass and energy transfer. The theoretical models systematically under or over predicted at various flow conditions: laminar, transition, and turbulent. These models were harmonized with experimental measurements to eliminate systematic under or over predictions; a total of 113 measured evaporation rates were used. The SM2E model can be used to estimate evaporation rates for pure liquids as well as liquid mixtures at laminar, transition, and turbulent flow conditions. However, due to limited availability of evaporation data, the model has so far only been tested against data for pure liquids and binary mixtures. The model can take evaporative cooling into account and when the temperature of the evaporating liquid or liquid mixture is known (e.g., isothermal evaporation), the SM2E model reduces to a mass transfer-only model.

  3. X-ray induced Sm{sup 3+} to Sm{sup 2+} conversion in fluorophosphate and fluoroaluminate glasses for the monitoring of high-doses in microbeam radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Vahedi, Shahrzad; Okada, Go; Morrell, Brian; Muzar, Edward; Koughia, Cyril; Kasap, Safa [Department of Electrical and Computer Engineering, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A9 (Canada); Edgar, Andy; Varoy, Chris [School of Chemical and Physical Sciences and MacDiarmid Institute, Victoria University of Wellington, Kelburn Parade (New Zealand); Belev, George; Wysokinski, Tomasz [Canadian Light Source, Inc., University of Saskatchewan, Saskatoon, Saskatchewan S7N 0X4 (Canada); Chapman, Dean [Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5 (Canada)

    2012-10-01

    Fluorophosphate and fluoroaluminate glasses doped with trivalent samarium were evaluated as sensors of x-ray radiation for microbeam radiation therapy at the Canadian Light Source using the conversion of trivalent Sm{sup 3+} to the divalent form Sm{sup 2+}. Both types of glasses show similar conversion rates and may be used as a linear sensor up to {approx}150 Gy and as a nonlinear sensor up to {approx}2400 Gy, where saturation is reached. Experiments with a multi-slit collimator show high spatial resolution of the conversion pattern; the pattern was acquired by a confocal fluorescence microscopy technique. The effects of previous x-ray exposure may be erased by annealing at temperatures exceeding the glass transition temperature T{sub g} while annealing at T{sub A} < T{sub g} enhances the Sm conversion. This enhancement is explained by a thermally stimulated relaxation of host glass ionic matrix surrounding x-ray induced Sm{sup 2+} ions. In addition, some of the Sm{sup 3+}-doped glasses were codoped with Eu{sup 2+}-ions but the results show that there is no marked improvement in the conversion efficiency by the introduction of Eu{sup 2+}.

  4. The constitution of alloys in the Al-rich corner of the Al-Si-Sm ternary system

    Energy Technology Data Exchange (ETDEWEB)

    Markoli, B.; Spaic, S. [Ljubljana Univ. (Slovenia). Faculty of Natural Science and Engineering; Zupanic, F. [Maribor Univ. (Slovenia). Faculty of Mechanical Engineering

    2001-09-01

    The constitution of alloys and the liquidus surface in the Al-rich corner of the Al-Si-Sm ternary system were determined by the examination of controlled heated and cooled specimens, as well as heat-treated specimens by means of optical and scanning electron microscopy, energy-dispersive X-ray spectroscopy, differential thermal analysis and X-ray diffraction. The Al-rich corner of the Al-Si-Sm ternary system comprises five regions of primary crystallisation ({alpha}{sub Al}, {beta}{sub Si}, Al{sub 3}Sm, Al{sub 2}Si{sub 2}Sm and AlSiSm) with following characteristic invariant reaction sequences: ternary eutectic reaction L {yields} {alpha}{sub Al} + {beta}{sub Si} + Al{sub 2}Si{sub 2}Sm, and two liquidus transition reactions, i. e., L + Al{sub 3}Sm {yields} {alpha}{sub Al} + AlSiSm, and L + AlSiSm {yields} {alpha}{sub Al} + Al{sub 2}Si{sub 2}Sm. Along with the position of ternary eutectic and both interstitial points in the Al-rich corner of the Al-Si-Sm ternary system, the temperatures for each reaction were determined. (orig.)

  5. In vivo efficacy of SM-8668 (Sch 39304), a new oral triazole antifungal agent.

    Science.gov (United States)

    Tanio, T; Ichise, K; Nakajima, T; Okuda, T

    1990-06-01

    SM-8668 (Sch 39304) is a new oral antifungal agent which we evaluated in comparison with fluconazole in various fungal infection models. The prophylactic effect of SM-8668 was excellent against systemic candidiasis, aspergillosis, and cryptococcosis in mice. The 50% effective dose for SM-8668 was assessed at 10 days after infection and was 0.18, 3.7, and 5.9 mg/kg (body weight), respectively, for the above-mentioned fungal diseases. Fluconazole was about four times less effective than SM-8668 against systemic candidiasis and was only slightly effective at doses of 80 and 25 mg/kg against systemic aspergilosis and cryptococcosis, respectively. SM-8668 was also about four to eight times more active than fluconazole against vaginal candidiasis in rats and against dermatophytic infection in guinea pigs. In addition, topical SM-8668 was as effective as topical miconazole or tioconazole against skin mycosis in guinea pigs. After oral administration, SM-8668 showed a maximum concentration in serum similar to that of fluconazole in both mice and rats, but the elimination half-life and area under the serum concentration-time curve for SM-8668 were twice those for fluconazole.

  6. Combustion synthesis of micron-sized Sm2Co17 particles via mechanochemical processing

    International Nuclear Information System (INIS)

    Liu, W.; McCormick, P.G.

    1998-01-01

    Full text: The spontaneous formation of Sm 2 Co 17 micron-sized particles via a mechanically induced combustion reaction has been investigated. Sm 2 Co 17 alloy particles of 0.1--2 μm in size embedded in a CaO matrix formed directly via a combustion reaction induced by milling the powder mixture of Sm 2 O 3 , CoO, CaO and Ca over a critical time. The micron-sized Sm 2 Co 17 particles were found to have the TbCu 7 -type structure and characterized by a coercivity value of 7.8 kOe while embedded in the CaO matrix. The effect of subsequent heat treatment on the structure and magnetic properties of as-milled samples was also investigated. Removal of the CaO by a carefully controlled washing process yielded micron-sized Sm 2 Co 17 particles without significant oxidation of the particles. These fine Sm 2 Co 17 particles can be used to produce anisotropic bulk or bonded magnets

  7. Structural and magnetic properties of SmCo-based magnetic films grown by electron-beam evaporation

    Energy Technology Data Exchange (ETDEWEB)

    Saravanan, P., E-mail: psdrdo@gmail.com [Defence Metallurgical Research Laboratory, Hyderabad 500058 (India); Vinod, V.T.P.; Černík, Miroslav [Institute for Nanomaterials, Advanced Technologies and Innovation, Department of Natural Sciences, Technical University of Liberec, Studentská 1402/2, Liberec 1, 461 17 (Czech Republic); Vishnuraj, R.; Arout Chelvane, J.; Kamat, S.V. [Defence Metallurgical Research Laboratory, Hyderabad 500058 (India); Hsu, Jen-Hwa, E-mail: jhhsu@phys.ntu.edu.tw [Department of Physics, National Taiwan University, Taipei 106, Taiwan (China)

    2015-07-01

    Sub-micron thick Sm–Co films (200 and 300 nm) with selective phase composition are grown on Si (100) substrates by electron-beam evaporation using Sm-lean alloy targets such as Sm{sub 4}Co{sub 96} and Sm{sub 8}Co{sub 92}. The structural and magnetic properties of Sm–Co films are characterized by x-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM) and super-conducting quantum interference device (SQUID) magnetometer. The Sm–Co films obtained with the Sm{sub 4}Co{sub 96} target exhibit Sm{sub 2}Co{sub 17} as a prominent phase; while the films produced with the Sm{sub 8}Co{sub 92} target show Sm{sub 2}Co{sub 7} as a major phase. Both the Sm–Co films reveal granular morphology; however, the estimated grain size values are slightly lower in the case of Sm{sub 2}Co{sub 7} films, irrespective of their thicknesses. Coercivity (H{sub c}) values of 1.48 and 0.9 kOe are achieved for the as-grown 200-nm thick Sm{sub 2}Co{sub 17} and Sm{sub 2}Co{sub 7}-films. Temperature-dependent magnetization studies confirm that the demagnetization behaviors of these films are consistent with respect to the identified phase composition. Upon rapid thermal annealing, maximum H{sub c} value of 8.4 kOe is achieved for the 200 nm thick Sm{sub 2}Co{sub 17}-films. As far as e-beam evaporated Sm–Co films are concerned, this H{sub c} value is one of the best values reported so far. - Highlights: • Electron-beam evaporation was exploited to grow sub-μm thick Sm–Co films. • Sm{sub 2}Co{sub 7} and Sm{sub 2}Co{sub 17} magnetic phases were crystallized using Sm-lean alloy targets. • Both 200 and 300-nm thick Sm–Co films revealed distinct granular morphology. • Sm–Co films of lower thickness exhibited high H{sub c} and low M{sub s} and vice-versa. • Coercivity value of 8.4 kOe achieved for the 200-nm thick Sm{sub 2}Co{sub 17}-films after RTA.

  8. Uso combinado de radiación UV-C y biorecubrimiento de quitosán con aceites esenciales para el control de hongos en papaya Maradol

    Directory of Open Access Journals (Sweden)

    Alfredo Vázquez-Ovando

    2018-05-01

    Full Text Available Resumen La antracnosis y pudrición blanda en frutos de papaya provocan deterioro de la calidad, así como grandes pérdidas durante el manejo postcosecha. El uso de estrategias individuales para el control de enfermedades resulta poco eficiente. Por lo anterior, en el presente estudio se evaluó el efecto sinérgico de varias estrategias de control sobre la incidencia de enfermedad causada por la inoculación de esporas de los hongos Colletotrichum gloeosporioides (Penz. y Rhizopus stolonifer (Ehrenb. en papaya var. Maradol. Se evaluaron tratamientos resultantes de la combinación del uso de biorecubrimientos compuestos elaborados con quitosán (15 g L-1 adicionadas con aceites esenciales (AE de clavo, tomillo y/o lima (5 ó 10 mL L-1 de cada AE y tres dosis de irradiación UV-C (0.97 kJ·m-2, 2 kJ·m-2 y 2.88 kJ·m-2, aplicados a las 12, 24 y 48 h post-inoculación de esporas de los fitopatógenos. El tratamiento donde se combinó el biorecubrimiento adicionado con 10 mL L-1 de AE de clavo y 10 mL L-1 de AE de tomillo y una dosis de irradiación UV-C de 2.88 kJ m-2 (B1T92 aplicado a las 24 h post-inoculación de esporas, logró mantener la incidencia de enfermedad (para ambos hongos evaluados a valores menores de 25% durante nueve días de almacenamiento a temperatura de 28 ± 3 °C y 80% de HR. Este mismo tratamiento redujo la velocidad específica de la enfermedad, con valores de 0.549 y 0.029 d-1 para C. gloeosporioidesy R. stolonifer, respectivamente. Otros tratamientos (B2T62, B1T34, B1T34, B1T94 presentaron actividad antifúngica (valores promedio de incidencia de 35% durante todo el almacenamiento para R. stolonifer. Los resultados de este trabajo demuestran que el efecto sinérgico del uso de biorecubrimientos de quitosán con aceites esenciales y energía UV-C controla el desarrollo de hongos causantes de antracnosis y pudrición blanda en frutos de papaya Maradol.

  9. Blue-green and red photoluminescence in CaTiO3:Sm

    International Nuclear Information System (INIS)

    Figueiredo, Alberthmeiry T. de; Longo, Valeria M.; Lazaro, Sergio de; Mastelaro, Valmor R.; De Vicente, Fabio S.; Hernandes, Antonio C.; Siu Li, Maximo; Varela, Jose A.; Longo, Elson

    2007-01-01

    Blue-green and red photoluminescence (PL) emission in structurally disordered CaTiO 3 :Sm (CT:Sm) powders was observed at room temperature with laser excitation at 350.7 nm. The perovskite-like titanate CT:Sm powders prepared by a soft chemical processing at different temperatures of annealing were structurally characterized by X-ray diffraction (XRD) and X-ray absorption near-edge structure (XANES). The results indicate that the generation of the broad PL band is related to order-disorder degree in the perovskite-like structure

  10. O efeito do treinamento combinado sobre a percepção subjetiva do esforço e sensação de prazer/desprazer em mulheres obesas

    Directory of Open Access Journals (Sweden)

    Ragami Chaves Alves

    2017-12-01

    Full Text Available As intensidades autosselecionadas observadas tanto na caminhada como no treinamento resistido em obesos são inferiores as recomendações do ACSM, (2011 as quais, promovem melhora na aptidão cardiorrespiratória e força muscular. A partir disso, surge a hipótese de combinar os exercícios, aeróbio e resistido em uma única sessão com o intuito de aumentar o volume de treinamento otimizando os ajustes fisiológicos tentando preservar baixos níveis de percepção subjetiva do esforço (PSE e sensações prazerosas (SPD observadas nessa intensidade. Desta maneira, o presente estudo teve três objetivos: 1 verificar ao longo de uma sessão de treinamento combinado a PSE e a SPD em mulheres obesas; 2 analisar se ocorrerá alteração na PSE e SPD entre os diferentes exercícios resistidos; 3 investigar se existe correlação entre a PSE e SPD. Participaram doze mulheres obesas não praticantes de exercício físico com idades de 39.2±11.1 anos e IMC: 33.6±1.2 kg.m-2 as quais, foram submetidas a uma sessão de treinamento combinado com duração total de 60 minutos. Ao longo da sessão foram reportadas a PSE e SPD. Para analisar os dados foi utilizado uma ANOVA de medidas repetidas seguido de um Post Hock de Bonferroni. Os resultados demonstram que o volume aumentado produziu baixos valores de PSE (~3 e sensações prazerosas (~3 ao longo da sessão. Não foi encontrado diferença significativa da PSE e SPD entre os exercícios resistidos e foi evidenciada uma relação negativa moderada significativa (r= -0.624; p= 0.001 com 95% IC: -0.710; -0.280 entre a PSE e SPD. Sendo assim, o treinamento combinado pode ser prescrito para mulheres obesas, pois, produz baixa percepção de esforço e sensações prazerosas.

  11. Enhancing Sm{sup 3+} red emission via energy transfer from Bi{sup 3+}→Sm{sup 3+} based on terbium bridge mechanism in Ca{sub 2}Al{sub 2}SiO{sub 7} phosphors

    Energy Technology Data Exchange (ETDEWEB)

    Li, Minhong; Wang, LiLi; Ran, Weiguang; Ren, Chunyan; Song, Zeling; Shi, Jinsheng, E-mail: jsshiqn@aliyun.com

    2017-04-15

    Currently, the key change for white-LED is to improve the luminescence efficiency of red phosphor. Sm{sup 3+} activated phosphor was considered due to suitable emission position of red light. However, the luminescence intensity in the red region is weak. For enhancing red-emitting of Sm{sup 3+}, Bi{sup 3+} and Tb{sup 3+} ions were introduced into Ca{sub 2}Al{sub 2}SiO{sub 7}:Sm{sup 3+} phosphors based on the concept of energy transfer. For Ca{sub 2}Al{sub 2}SiO{sub 7}:Bi{sup 3+}, Sm{sup 3+} samples, it can be observed that the energy transfer process was blocked. Hence, Tb{sup 3+} was introduced into Ca{sub 2}Al{sub 2}SiO{sub 7}:Bi{sup 3+}, Sm{sup 3+} samples to increase Sm{sup 3+} luminescence intensity based on Bi{sup 3+}→Tb{sup 3+}→Sm{sup 3+} energy transfer process. Compared with Sm{sup 3+} single-doped Ca{sub 2}Al{sub 2}SiO{sub 7} phosphor, the luminescence intensity of Sm{sup 3+} was enhanced by 2.6 times. It can be found that Tb{sup 3+} ions play a role of storing the energy or transfer bridge from Bi{sup 3+}→ Sm{sup 3+} by investigating the Ca{sub 2}Al{sub 2}SiO{sub 7}:Bi{sup 3+}, Tb{sup 3+} and Ca{sub 2}Al{sub 2}SiO{sub 7}:Tb{sup 3+}, Sm{sup 3+} energy transfer mechanism. All these results suggest that terbium branch mechanism plays an important role on enhancing activators luminescence intensity.

  12. Determinación de los parámetros de corrosión y desgaste del par acero/aluminio en presencia de líquidos iónicos

    OpenAIRE

    Jerez Mesa, Ramón

    2008-01-01

    El presente proyecto presenta resultados obtenidos en ensayos utilizando LI combinados con aluminio 2011 y acero F-1310, tanto en ensayos de corrosión como de tribología. Escuela Técnica Superior de Ingeniería Industrial

  13. Structure of smAKAP and its regulation by PKA-mediated phosphorylation

    Science.gov (United States)

    Burgers, Pepijn P.; Bruystens, Jessica; Burnley, Rebecca J.; Nikolaev, Viacheslav O.; Keshwani, Malik; Wu, Jian; Janssen, Bert J. C.; Taylor, Susan S.; Heck, Albert J. R.; Scholten, Arjen

    2016-01-01

    The A-kinase anchoring protein (AKAP) smAKAP has three extraordinary features; it is very small, it is anchored directly to membranes by acyl motifs, and it interacts almost exclusively with the type I regulatory subunits (RI) of cAMP-dependent kinase (PKA). Here, we determined the crystal structure of smAKAP’s A-kinase binding domain (smAKAP-AKB) in complex with the dimerization/docking (D/D) domain of RIα which reveals an extended hydrophobic interface with unique interaction pockets that drive smAKAP’s high specificity for RI subunits. We also identify a conserved PKA phosphorylation site at Ser66 in the AKB domain which we predict would cause steric clashes and disrupt binding. This correlates with in vivo colocalization and fluorescence polarization studies, where Ser66 AKB phosphorylation ablates RI binding. Hydrogen/deuterium exchange studies confirm that the AKB helix is accessible and dynamic. Furthermore, full-length smAKAP as well as the unbound AKB is predicted to contain a break at the phosphorylation site, and circular dichroism measurements confirm that the AKB domain loses its helicity following phosphorylation. As the active site of PKA’s catalytic subunit does not accommodate α-helices, we predict that the inherent flexibility of the AKB domain enables its phosphorylation by PKA. This represents a novel mechanism, whereby activation of anchored PKA can terminate its binding to smAKAP affecting the regulation of localized cAMP signaling events. PMID:27028580

  14. Hydrogen stability of SmCo5 permanent magnet

    International Nuclear Information System (INIS)

    Lukin, A.; Rabinovich, Y.; Bala, H.

    2001-01-01

    The present work has been performed with purpose to determine the level of hydrogen stability of sintered SmCo 5 permanent magnets by means of accelerated tests, to study the effect of hydrogen on the magnetic and mechanical properties of the permanent magnets and to establish the criteria of hydrogenation level and the activation energy of this process. In addition, the effect of hydrogen on the properties of sintered SmCo 5 permanent magnets in specific conditions of exploitation and storage durability of instruments was studied

  15. Thermal analysis of the heat recuperator of a combined cycle thermoelectric central; Analisis termico del recuperador de calor de una central termoelectrica de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Romero Paredes, Hernando; Sanchez, I; Lazcano, L C; Ambriz, Juan Jose; Alvarez, M [Universidad Autonoma Metropolitana-Iztapalapa, Mexico, D. F. (Mexico); Gonzalez, O [Comision Federal de Electricidad, Tula (Mexico)

    1997-12-31

    The thermoelectric centrals of the combined cycle type (Brayton Cycle and Rankine Cycle) present a series of opportunities to increase the efficiency of the combined cycle or of the generated power. This paper shows the methodology for the performance of energy balances in a heat recuperator (H. R.), typically employed in the combined cycle stations operating in Mexico, for the assessment of the energy harnessing in the different sections conforming a H. R. The effect of the installation of evaporative coolers and/or an absorption cooling system at the gas turbine compressor intake on the steam generation in the heat recuperator, is evaluated. This extra generation of steam is quantified for its potential use in the same absorption refrigeration system. From the assessment, it follows up that the steam generation in the H.R. is inversely proportional to the ambient temperature and that, although the increased amount of steam generated can not be harnessed in total by the steam turbine, the remaining fraction is good enough to cover the heat demand for the operation of the refrigeration system. [Espanol] Las centrales termoelectricas del tipo ciclo combinado (ciclo Brayton y ciclo Rankine) presentan un conjunto de oportunidades para incrementar la eficiencia del ciclo combinado o bien la potencia generada. En el presente trabajo se expone la metodologia para realizar los balances de energia en un recuperador de calor (R.C.) tipicamente utilizado en las Centrales de Ciclo Combinado (CCC) que operan en Mexico, para evaluar el aprovechamiento de la energia en las diferentes secciones que conforman un R.C. Se evalua el efecto que tiene la instalacion de enfriadores evaporativos y/o un sistema de enfriamiento por absorcion en la succion del compresor de la turbina de gas sobre la generacion de vapor en el recuperador de calor. Se cuantifica esta generacion extra de vapor para su posible utilizacion en el mismo sistema de refrigeracion por absorcion. De la evaluacion se

  16. Thermal analysis of the heat recuperator of a combined cycle thermoelectric central; Analisis termico del recuperador de calor de una central termoelectrica de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Romero Paredes, Hernando; Sanchez, I.; Lazcano, L. C.; Ambriz, Juan Jose; Alvarez, M. [Universidad Autonoma Metropolitana-Iztapalapa, Mexico, D. F. (Mexico); Gonzalez, O. [Comision Federal de Electricidad, Tula (Mexico)

    1996-12-31

    The thermoelectric centrals of the combined cycle type (Brayton Cycle and Rankine Cycle) present a series of opportunities to increase the efficiency of the combined cycle or of the generated power. This paper shows the methodology for the performance of energy balances in a heat recuperator (H. R.), typically employed in the combined cycle stations operating in Mexico, for the assessment of the energy harnessing in the different sections conforming a H. R. The effect of the installation of evaporative coolers and/or an absorption cooling system at the gas turbine compressor intake on the steam generation in the heat recuperator, is evaluated. This extra generation of steam is quantified for its potential use in the same absorption refrigeration system. From the assessment, it follows up that the steam generation in the H.R. is inversely proportional to the ambient temperature and that, although the increased amount of steam generated can not be harnessed in total by the steam turbine, the remaining fraction is good enough to cover the heat demand for the operation of the refrigeration system. [Espanol] Las centrales termoelectricas del tipo ciclo combinado (ciclo Brayton y ciclo Rankine) presentan un conjunto de oportunidades para incrementar la eficiencia del ciclo combinado o bien la potencia generada. En el presente trabajo se expone la metodologia para realizar los balances de energia en un recuperador de calor (R.C.) tipicamente utilizado en las Centrales de Ciclo Combinado (CCC) que operan en Mexico, para evaluar el aprovechamiento de la energia en las diferentes secciones que conforman un R.C. Se evalua el efecto que tiene la instalacion de enfriadores evaporativos y/o un sistema de enfriamiento por absorcion en la succion del compresor de la turbina de gas sobre la generacion de vapor en el recuperador de calor. Se cuantifica esta generacion extra de vapor para su posible utilizacion en el mismo sistema de refrigeracion por absorcion. De la evaluacion se

  17. Effects of Biofertilizers Combined with Different Soil Amendments on Potted Rice Plants Efecto de Biofertilizantes Combinado con Enmiendas del Suelo sobre Plantas de Arroz en Macetas

    Directory of Open Access Journals (Sweden)

    Arshad Javaid

    2011-03-01

    Full Text Available This pot study investigated the effect of the combined application of two commercial biofertilizers viz. Biopower and EM (Effective Microorganisms on rice (Oryza sativa L. growth and yield in soils amended with farmyard manure, green manure, and NPK fertilizers. Biopower is a product of the Nuclear Institute for Biotechnology and Genetic Engineering (NIBGE, Pakistan, which contains species of associative and endophytic diazotrophs. EM (effective microorganisms, a product developed by Japanese scientists, consists of co-existing beneficial microorganisms, mainly species of photosynthetic and lactic acid bacteria, as well as yeast. Applying Biopower adversely affected plant growth and yield in NPK fertilizer amendment. Conversely, this biofertilizer markedly enhanced plant growth and yield in green manure amended soil while its effect was not significant in farmyard manure amendment. In green manure amendment, applying EM enhanced grain yield by 46%. Co-inoculation of Biopower and EM evidently improved root and shoot growth in farmyard manure amended soil. This study concludes that the two biofertilizers clearly enhanced shoot biomass and grain yield in green manure amended soils.El presente estudio en macetas fue realizado para investigar el efecto de la aplicación combinada de dos biofertilizantes comerciales, Biopower y EM (Effective Microorganisms, en el crecimiento y producción de arroz (Oryza sativa L. en suelos enmendados con estiércol de granja, abono verde y fertilizantes NPK. Biopower es un producto del Nuclear Institute for Biotechnology and Genetic Engineering (NIBGE, Pakistán, que contiene especies de diazótrofos asociativos y endofíticos. Effective Microorganisms es un producto desarrollado por científicos japoneses que consiste en microorganismos benéficos co-existentes, principalmente especies de bacterias fotosintéticas y ácido lácticas, y levadura. La aplicación de Biopower afectó adversamente el crecimiento y

  18. Structural and electrical properties of Sm{sup 3+} substituted PZT ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Pandey, S.K. [Solid State Physics Laboratory, Timarpur, Delhi 110 054 (India)], E-mail: 628@ssplnet.org; Thakur, O.P.; Bhattacharya, D.K. [Solid State Physics Laboratory, Timarpur, Delhi 110 054 (India); Prakash, Chandra [DRDO Bhawan, DHQ, New Delhi 110 011 (India); Chatterjee, Ratnamala [Department of Physics, Indian Institute of Technology, New Delhi 110 016 (India)

    2009-01-22

    Samarium modified lead zirconate titanate (PSZT: Pb{sub 1-x}Sm{sub x}(Zr{sub 0.65}Ti{sub 0.35})O{sub 3}: x = 0, 0.02, 0.04, 0.06) ceramics were synthesized by solid state ceramic route. XRD shows single-phase formation with rhombohedral structure up to x = 0.04. With Sm-substitution, the grain size first increases up to x = 0.02 and then decreases. A metal/ferroelectric/metal (MFM) structure was made by depositing gold electrode on the flat surfaces for electrical measurements. All samples show normal ferroelectric behaviour, however, a squareness of P-E loop (polarization vs. electric field) was observed to increase with Sm content. Higher electromechanical coupling coefficients (K{sub p} and K{sub t}) have been achieved for the PZT with 6 mol% Sm substitution and having fine grain size.

  19. Simplified syntheses of the water-soluble chiral shift reagents Sm-(R)-pdta and Sm-(S)-pdta

    Czech Academy of Sciences Publication Activity Database

    Hrubá, L.; Buděšínský, Miloš; Pícha, Jan; Jiráček, Jiří; Vaněk, Václav

    2013-01-01

    Roč. 54, č. 47 (2013), s. 6296-6297 ISSN 0040-4039 Institutional support: RVO:61388963 Keywords : NMR * chiral shift reagents * Sm-pdta * PDTA * samarium * 1,2-diaminopropane Subject RIV: CC - Organic Chemistry Impact factor: 2.391, year: 2013

  20. Standard enthalpy of formation of Sm6UO12 acid dissolution calorimetry

    International Nuclear Information System (INIS)

    Venkata Krishnan, R.; Jogeswararao, G.; Ananthasivan, K.

    2016-01-01

    The standard molar enthalpies of formation of Δ f (298 K) of Sm 6 UO 12 have been determined by using an indigenously developed isoperibol acid solution calorimeter. The water equivalent of this calorimeter was determined by electrical calibration. The accuracy of measurement were determined by using standard materials KCl and tris(hydroxyl methyl) amino-methane (TRIS) and was found to be within ±2%. The enthalpies of solution at 298 K of Sm 2 O 3 , UO 3 and Sm 6 UO 12 were measured by using this calorimeter. From these experimental results the enthalpies of formation of Sm 6 UO 12 at 298 K were computed by using Hess's law of summation. (author)

  1. Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2.

    Directory of Open Access Journals (Sweden)

    Mark S Pearson

    Full Text Available The large extracellular loop of the Schistosoma mansoni tetraspanin, Sm-TSP-2, when fused to a thioredoxin partner and formulated with Freund's adjuvants, has been shown to be an efficacious vaccine against murine schistosomiasis. Moreover, Sm-TSP-2 is uniquely recognised by IgG(1 and IgG(3 from putatively resistant individuals resident in S. mansoni endemic areas in Brazil. In the present study, we expressed Sm-TSP-2 at high yield and in soluble form in E. coli without the need for a solubility enhancing fusion partner. We also expressed in E. coli a chimera called Sm-TSP-2/5B, which consisted of Sm-TSP-2 fused to the immunogenic 5B region of the hookworm aspartic protease and vaccine antigen, Na-APR-1. Sm-TSP-2 formulated with alum/CpG showed significant reductions in adult worm and liver egg burdens in two separate murine schistosomiasis challenge studies. Sm-TSP-2/5B afforded significantly greater protection than Sm-TSP-2 alone when both antigens were formulated with alum/CpG. The enhanced protection obtained with the chimeric fusion protein was associated with increased production of anti-Sm-TSP-2 antibodies and IL-4, IL-10 and IFN-γ from spleen cells of vaccinated animals. Sera from 666 individuals from Brazil who were infected with S. mansoni were screened for potentially deleterious IgE responses to Sm-TSP-2. Anti-Sm-TSP-2 IgE to this protein was not detected (also shown previously for Na-APR-1, suggesting that the chimeric antigen Sm-TSP-2/5B could be used to safely and effectively vaccinate people in areas where schistosomes and hookworms are endemic.

  2. Brillouin spectroscopy with surface acoustic waves on intermediate valent, doped SmS

    International Nuclear Information System (INIS)

    Schaerer, U.; Jung, A.; Wachter, P.

    1998-01-01

    Brillouin scattering on surface acoustic waves is a very powerful tool to determine the elastic constants of intermediate valent crystals, since the method is non-destructive and no mechanical contact is needed. A strong evidence for intermediate valence is a negative value of Poisson's ratio, which describes the behavior of the volume under uniaxial pressure. SmS by itself makes a semiconductor-metal transition at a pressure of more than 6.5 kbar. When substituting the divalent Sm by a trivalent cation, like Y, La or Tm, SmS can become - depending on the doping concentration - intermediate valent without any applied, external pressure. In this work, we will present measurements of the velocities of the surface acoustic waves and the calculation of the elastic constants of La- and Tm-doped SmS compounds. We found a clear dependence of Poisson's ratio on the doping concentration and on the valence of the materials. Furthermore, we will discuss the mechanism leading to intermediate valence when substituting Sm. Besides the internal, chemical pressure, which is produced by the built in trivalent cations with their smaller ionic radii, we have clear evidence, that the free electrons in the 5d band, induced by the substituting atoms, also play an important role in making doped SmS intermediate valent. (orig.)

  3. Efectos del parto prematuro y retraso en el crecimiento fetal sobre los factores de riesgo cardiovascular durante el curso de la vida entre niños y adolescentes de escuelas oficiales de Bogotá, Colombia: Estudio FUPRECOL

    OpenAIRE

    Becerra Narváez, Ibelice Rocio

    2017-01-01

    Antecedentes. Tanto la restricción del crecimiento fetal y el parto pretérmino han sido asociados con el riesgo cardiometabólico en jóvenes y adultos. Sin embargo, sus efectos combinados sobre la salud cardiometabólica en niños y jóvenes son escasos. Objetivos. Este estudio tuvo como objetivo evaluar los efectos del peso al nacer y la edad gestacional combinados sobre los factores de riesgo cardiovascular durante el curso de la vida y la obesidad entre niños y jóvenes de edad escolar de C...

  4. Isolated centres versus defect associates in Sm3+-doped CeO2: a spectroscopic investigation

    International Nuclear Information System (INIS)

    Tiseanu, Carmen; Avram, Daniel; Cojocaru, Bogdan; Parvulescu, Vasile I; Vela-Gonzalez, Andrea V; Sanchez-Dominguez, Margarita

    2013-01-01

    The interactions between Sm 3+ and oxygen vacancies in CeO 2 are probed by the use of tuneable laser excited time-resolved photoluminescence and Raman spectroscopies. It is found that Sm 3+ (with doping concentrations of 0.1, 0.3, 1 and 5 wt%) substitutes largely for Ce 4+ in sites with cubic symmetry and the corresponding emission is sensitized via the Ce 4+ –O 2− charge-transfer band of CeO 2 . It is established from the photoluminescence spectra measured at long delay after the laser pulse that the local environment around cubic Sm 3+ centres is not changed with concentration and ceria size. In addition to cubic symmetry Sm 3+ centres, low-symmetry Sm 3+ centres tentatively assigned to the Sm 3+ –oxygen vacancy associates of nearest-neighbour type are also observed. Their emission is preferentially excited via the weak f–f absorption transitions of Sm 3+ . A relatively strong concentration-induced quenching of Sm 3+ emission was inferred from the decrease in the average emission lifetimes from 2.1 ms (0.1 wt%) to 0.87 ms (5 wt%). The local environments of Sm 3+ and Eu 3+ in CeO 2 are also compared on the basis of their emission spectra and decays. (paper)

  5. Real-time observation of growth and orientation of Sm-Ba-Cu-O phases on a Sm-211 whisker substrate by high-temperature optical microscopy

    Czech Academy of Sciences Publication Activity Database

    Sun, J.L.; Huang, Y.B.; Cheng, L.; Yao, X.; Lai, Y.J.; Jirsa, Miloš

    2009-01-01

    Roč. 9, č. 2 (2009), 898-902 ISSN 1528-7483 R&D Projects: GA ČR GA202/08/0722 Institutional research plan: CEZ:AV0Z10100520 Keywords : high-temperature optical microscopy * growth and orientation of Sm-Ba-Cu-O phases * Sm-211 whisker substrate Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 4.162, year: 2009

  6. Coercive force changes in Sm(CoFeCuZr)z during step-like heat treatments

    International Nuclear Information System (INIS)

    Puzanova, T.Z.; Shchegoleva, N.N.; Sakhnova, L.V.; Majkov, V.G.; Shur, Ya.S.; Nikolaeva, N.V.

    1987-01-01

    Sm(Co 0.67 Fe 0.22 Cu 0.08 Zr 0.03 ) 8.35 alloy, contaning two homogeneous solid solutions SmM 6.85 and SmM 7.75 (M=Co, Fe, Cu, Zr) after high-temperature treatment, is investigated. It is shown, that after isothermal tempering at 800 deg C, SmM 6.85 and SmM 7.75 are close by microstructure and their coercive forces change in a different way during step-like cooling within 700-400 deg C interval. Possibility of producing material, single-phase in magnetic relation, is discussed

  7. SmShb, the SH2-Containing Adaptor Protein B of Schistosoma mansoni Regulates Venus Kinase Receptor Signaling Pathways.

    Directory of Open Access Journals (Sweden)

    Marion Morel

    Full Text Available Venus kinase receptors (VKRs are invertebrate receptor tyrosine kinases (RTKs formed by an extracellular Venus Fly Trap (VFT ligand binding domain associated via a transmembrane domain with an intracellular tyrosine kinase (TK domain. Schistosoma mansoni VKRs, SmVKR1 and SmVKR2, are both implicated in reproductive activities of the parasite. In this work, we show that the SH2 domain-containing protein SmShb is a partner of the phosphorylated form of SmVKR1. Expression of these proteins in Xenopus oocytes allowed us to demonstrate that the SH2 domain of SmShb interacts with the phosphotyrosine residue (pY979 located in the juxtamembrane region of SmVKR1. This interaction leads to phosphorylation of SmShb on tyrosines and promotes SmVKR1 signaling towards the JNK pathway. SmShb transcripts are expressed in all parasite stages and they were found in ovary and testes of adult worms, suggesting a possible colocalization of SmShb and SmVKR1 proteins. Silencing of SmShb in adult S. mansoni resulted in an accumulation of mature sperm in testes, indicating a possible role of SmShb in gametogenesis.

  8. SmShb, the SH2-Containing Adaptor Protein B of Schistosoma mansoni Regulates Venus Kinase Receptor Signaling Pathways.

    Science.gov (United States)

    Morel, Marion; Vanderstraete, Mathieu; Cailliau, Katia; Hahnel, Steffen; Grevelding, Christoph G; Dissous, Colette

    2016-01-01

    Venus kinase receptors (VKRs) are invertebrate receptor tyrosine kinases (RTKs) formed by an extracellular Venus Fly Trap (VFT) ligand binding domain associated via a transmembrane domain with an intracellular tyrosine kinase (TK) domain. Schistosoma mansoni VKRs, SmVKR1 and SmVKR2, are both implicated in reproductive activities of the parasite. In this work, we show that the SH2 domain-containing protein SmShb is a partner of the phosphorylated form of SmVKR1. Expression of these proteins in Xenopus oocytes allowed us to demonstrate that the SH2 domain of SmShb interacts with the phosphotyrosine residue (pY979) located in the juxtamembrane region of SmVKR1. This interaction leads to phosphorylation of SmShb on tyrosines and promotes SmVKR1 signaling towards the JNK pathway. SmShb transcripts are expressed in all parasite stages and they were found in ovary and testes of adult worms, suggesting a possible colocalization of SmShb and SmVKR1 proteins. Silencing of SmShb in adult S. mansoni resulted in an accumulation of mature sperm in testes, indicating a possible role of SmShb in gametogenesis.

  9. Synthesis, characterization and antimicrobial activity of some nitrilotriacetic acid−V(III, −Sn(II, −Sm(II and −Sm(III complexes

    Directory of Open Access Journals (Sweden)

    Mohsen S. Asker

    2011-04-01

    Full Text Available Four new complexes [V(NTA(H2O 2]•H2O (1, H[Sn(NTA] (2, H[Sm(NTA]•H2O (3, and [Sm(NTA(H2O 2]•H2O (4 were obtained during the reactions of metal salts (VCl3, SnCl2•2H2O, SnCl4, Sm(NO32•6H2O and SmCl3•6H2O with nitrilotriacetic acid, H3NTA. The infrared and 1H-NMR spectra of the solid complexes have been obtained and assigned. Thermogravimetric analyses were also carried out. The data obtained agree with the proposed structures and show that the complexes decomposed to the corresponding metal oxide. The ligand and their metal complexes were screened for their antimicrobial activities by the agar-well diffusion technique using DMSO as a solvent against the following bacterial species: Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Aspergillus niger, Aspergillus flavus, Saccharomyces cerevisiae and Candida albicans. The obtained results were compared with some types of known antibiotics. The minimum inhibitory concentration (MIC values were calculated at 30 °C for 24−48 h. The activity data show that the complexes are more potent antimicrobials than the parent ligand.

  10. Luminescence and energy transfer of Sm3+ and Eu3+ in Ca2PO4Cl

    International Nuclear Information System (INIS)

    Wang, Zhijun; Li, Panlai; Yang, Zhiping; Guo, Qinglin

    2014-01-01

    Sm 3+ , Eu 3+ , and Sm 3+ –Eu 3+ doped Ca 2 PO 4 Cl phosphors are synthesized by a solid-state method. Ca 2 PO 4 Cl:Sm 3+ can produce red emission under the 400 nm radiation excitation, and the emission peak is located at 601 nm, which is assigned to the 4 G 5/2 → 6 H 7/2 transition of Sm 3+ . Ca 2 PO 4 Cl:Eu 3+ can create red emission under the 392 nm radiation excitation, and the strongest peak is located at 620 nm, which is attributed to the 5 D 0 → 7 F 2 transition of Eu 3+ . The energy transfer from Sm 3+ to Eu 3+ in Ca 2 PO 4 Cl has been validated and the critical distance (R c ) of Sm 3+ to Eu 3+ in Ca 2 PO 4 Cl is calculated to be 1.14 nm. With increasing Eu 3+ doping concentration, the energy transfer efficiency (Sm 3+ →Eu 3+ ) gradually increases to 53.7%. The luminescence property of Ca 2 PO 4 Cl:Sm 3+ , Eu 3+ can be tuned by properly tuning the relative ratio of Sm 3+ –Eu 3+ , and the emission intensity of Ca 2 PO 4 Cl:Eu 3+ can be greatly enhanced by codoped Sm 3+ . - Highlights: • Ca 2 PO 4 Cl:Sm 3+ , Eu 3+ can produce red emission under the 400 nm radiation excitation. • The energy transfer from Sm 3+ to Eu 3+ in Ca 2 PO 4 Cl has been validated. • The critical distance of Sm 3+ to Eu 3+ in Ca 2 PO 4 Cl is calculated to be 1.14 nm

  11. Synthesis and DNA interaction of a Sm(III) complex of a Schiff base ...

    African Journals Online (AJOL)

    The interaction between the Sm(III) complex of an ionic Schiff base [HL]-, derived from vanillin and L-tryptophan, and herring sperm DNA at physiological pH (7.40) has been studied by UV-Vis absorption, fluorescence and viscosity methods. The binding ratios nSm(III) : nK[HL] = 1:1 and nSm(III)L: nDNA =5:1 were confirmed ...

  12. Nuclear translocation of the cytoskeleton-associated protein, smALP, upon induction of skeletal muscle differentiation

    International Nuclear Information System (INIS)

    Cambier, Linda; Pomies, Pascal

    2011-01-01

    Highlights: → The cytoskeleton-associated protein, smALP, is expressed in differentiated skeletal muscle. → smALP is translocated from the cytoplasm to the nucleus of C2C12 myoblasts upon induction of myogenesis. → The differentiation-dependent nuclear translocation of smALP occurs in parallel with the nuclear accumulation of myogenin. → The LIM domain of smALP is essential for the nuclear accumulation of the protein. → smALP might act in the nucleus to control some critical aspect of the muscle differentiation process. -- Abstract: The skALP isoform has been shown to play a critical role in actin organization and anchorage within the Z-discs of skeletal muscles, but no data is available on the function of the smALP isoform in skeletal muscle cells. Here, we show that upon induction of differentiation a nuclear translocation of smALP from the cytoplasm to the nucleus of C2C12 myoblasts, concomitant to an up-regulation of the protein expression, occurs in parallel with the nuclear accumulation of myogenin. Moreover, we demonstrate that the LIM domain of smALP is essential for the nuclear translocation of the protein.

  13. Standard Missile-6 (SM-6)

    Science.gov (United States)

    2016-12-01

    attack or Anti-Ship Cruise Missiles in flight. The SM-6 ERAM program is an evolutionary, capabilities based acquisition program that will use spiral ...Prior SAR Total O&S Estimates - Dec 2014 SAR 460.3 Programmatic/Planning Factors 0.0 Cost Estimating Methodology 0.0 Cost Data Update 0.0 Labor Rate

  14. Modernization of the subsystem man-machine interface for operation of the combined cycle central of Gomez Palacio; Modernizacion del subsistema de interfaz hombre-maquina para operacion de la central de ciclo combinado de Gomez Palacio

    Energy Technology Data Exchange (ETDEWEB)

    Rivas S, Alfonso; Uribe B, Carlos E; Alvarez C, Victor [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2002-07-01

    In order to take care of the modernization of the Combined Cycle Central of Gomez Palacio (CCCGP) of the Comision Federal de Electricidad (CFE), the Instituto de Investigaciones Electricas (IIE), through the Management of Supervision of Processes (GSP) developed the subsystem of Interface Man-Machine (IMM), to replace the workstations that are deteriorated and obsolete by personal computers, maintaining the same functions of the IMM of the present system, including the management and processing functions that at the present time another system makes. Also, to replace the equipment of the concentrators of communications by a PC with greater capacity, than allows improving in general the flexibility and robustness of the system. Among the main functions integrated in the IMM subsystem there are: the communications master with the controllers (equipment SAC), redundancy of servers, database, historical registry storage, alarm management, tabulations, tendency graphs in real time and historical, process diagrams and Control Panels. [Spanish] Con el objeto de atender las necesidades de modernizacion de la Central de Ciclo Combinado Gomez Palacio (CCCGP) de la Comision Federal de Electricidad (CFE), el Instituto de Investigaciones Electricas (IIE), a traves de la Gerencia de Supervision de Procesos (GSP) desarrollo el subsistema de Interfaz Hmbre-Maquina (IHM), para reemplazar las estaciones de trabajo que se encuentran deterioradas y obsoletas por computadoras personales, manteniendo las mismas funciones de la IHM del sistema actual, incluyendo las funciones de administracion y procesamiento que en la actualidad realiza otro sistema. Asimismo, para reemplazar los equipos de los concentradores de comunicaciones por PC con mayor capacidad, que permitan mejorar la flexibilidad y robustez del sistema en general. Entre las principales funciones integradas en el subsistema de IHM se encuentran: el Maestro de comunicaciones con los controladores (equipo SAC), redundancia de

  15. Afrontamiento, salud mental y felicidad bajo huelga y ocupación universitaria

    Directory of Open Access Journals (Sweden)

    Emilio Moyano-Díaz

    2017-01-01

    Full Text Available Se identificó la relación entre estrategias de enfrentamiento, salud mental (SM y felicidad en trabajadores de una universidad en huelga y ocupación estudiantil, de acuerdo con status laboral - académico o administrativo-, grado de concordancia con el movimiento estudiantil y sexo. Ciento sesenta y dos participantes respondieron a la Escala de felicidad subjetiva y estrategias de enfrentamiento, y a la Escala de Goldberg (GHQ12. Obtuvimos y discutimos: 1 el uso del humor está asociado con SM y la felicidad y ésta, a la reevaluación cognitiva, enfrentamiento religioso y bajo enfrentamiento de evitación, 2 mayor malestar por la ocupación peor SM, 3 no tener acceso a el espacio de trabajo está asociado con peor SM, más con iguales niveles de felicidad que los que tuvieron acceso, 4 el enfrentamiento varía de acuerdo con el status de académico o administrativo y con el sexo, 5 SM y felicidad no varían de acuerdo con el status académico, 6 aquellos que son pro-movimiento estudiantil presentan mejor SM que aquellos que no lo son.

  16. Avaliação do tratamento combinado de lixiviado de aterro sanitário e esgoto sanitário em sistema de lodos ativados

    OpenAIRE

    Edilincon Martins de Albuquerque

    2012-01-01

    Um dos principais resíduos gerados nos aterros é o lixiviado, que possui elevada concentração de matéria orgânica biodegradável e refratária e de matéria inorgânica, como nitrogênio amoniacal e metais pesados. O tratamento combinado de lixiviado com esgoto sanitário tem sido utilizado em algumas estações de tratamento de esgoto (ETE) brasileiras. No entanto, o processo ainda sofre vários questionamentos e incertezas, especialmente sobre os efeitos da adição do lixiviado sobre o sistema de tra...

  17. Preparation and Luminescent Properties of the antibacterial materials of the La3+ Doped Sm3+-Hydroxyapatite

    Science.gov (United States)

    Lv, Yuguang; Shi, Qi; Jin, Yuling; Ren, Hengxin; Qin, Yushan; Wang, Bo; Song, Shanshan

    2018-03-01

    In this paper, the La3+-doped Sm3+ hydroxyapatite (La/Sm/HAP) complexes were prepared by a precipitation method. The sample was defined by IR spectra, fluorescence spectra and X ray diffraction analysis et al. The structure of complexes were discussed. The emission wavelength of heat treatment of Sm3+ do not change, but will affect the intensity of the peak Sm3+ luminescence properties and the occupy hydroxyapatite in the lattice Ca( II )and Ca( I ) loci with Sm3+ doped concentration and the proportion of the sintering temperature change and change: The nano hydroxyapatite complex of the La3+ doped samarium obtain the good fluorescence intensity, by La3+ doping content of Sm3+ were hydroxyapatite 6% (La3+, Sm3+ mole ratio) device. The complex of La3+ doped samarium HAP have Stable chemical property, fluorescence property and excellent biological activity. The ligand HAP absorbs energy or captures an electron-hole pair and then transfers it to the lanthanide ions. The catalytic activity influence of the La3+-doped Sm3+hydroxyapatite was discussed, the La/Sm/HAP had excellent antibacterial property, which used as potential biological antibacterial material.

  18. Three-loop SM beta-functions for matrix Yukawa couplings

    Directory of Open Access Journals (Sweden)

    A.V. Bednyakov

    2014-10-01

    Full Text Available We present the extension of our previous results for three-loop Yukawa coupling beta-functions to the case of complex Yukawa matrices describing the flavour structure of the SM. The calculation is carried out in the context of unbroken phase of the SM with the help of the MINCER program in a general linear gauge and cross-checked by means of MATAD/BAMBA codes. In addition, ambiguities in Yukawa matrix beta-functions are studied.

  19. Optical imaging of the transport properties of S-Sm-S junctions

    International Nuclear Information System (INIS)

    Tsumura, K; Nomura, S; Akazaki, T; Takayanagi, H

    2009-01-01

    We study the optical effects on superconductor-normal metal superconductor (S-Sm-S) junctions composed of two-dimensional electron gas (2DEG) in a GaAs/AlGaAs heterostructure and NbN superconducting electrodes. When the whole junction area was illuminated at λ = 800 nm, we observe a reduction in the normal resistance due to an increase in the sheet carrier density of the 2DEG, and the enhancement of the Andreev reflection probability. To reveal its origin, we performed scanning photo-voltage measurement by employing an optical microscope. The obtained image plots show maxima and minima of the photo-voltage change along the S-Sm interfaces. Those structures are considered to reflect the modulation of the barrier height at S-Sm interface and the increase in the scattering by photo-generated carriers. It is demonstrated that the scanning photo-voltage measurement is one of the most powerful tools as a local probe of the transport properties of S-Sm-S junctions.

  20. The direct limit on the Higgs Mass and the SM Fit

    International Nuclear Information System (INIS)

    Chanowitz, Michael S.

    2003-01-01

    Because of two 3σ anomalies, the Standard Model (SM) fit of the precision electroweak data has a poor confidence level, CL = 0.02. Since both anomalies involve challenging systematic issues, it might appear that the SM could still be valid if the anomalies resulted from underestimated systematic error. Indeed the CL of the global fit could then increase to 0.71, but that fit predicts a small Higgs boson mass, m H = 45 GeV, that is inconsistent at 95% CL with the lower limit, m H > 114 GeV, established by direct searches. The data then favor new physics whether the anomalous measurements are excluded from the fit or not, and the Higgs boson mass cannot be predicted until the new physics is understood. Some measure of statistical fluctuation would be needed to maintain the validity of the SM. New physics is favored, but the SM is not definitively excluded

  1. Subcoulomb fusion of 16O in odd Sm isotopes

    International Nuclear Information System (INIS)

    Pacheco, A.J.

    1989-01-01

    Cross sections for the formation of evaporation residues were measured for the reaction of 16 O with the odd 147 Sm and 149 Sm nuclei at near barrier energies. The results are well described by statistical model calculations. Fusion cross sections as a function of energy do not show any unusual behaviour that could be attributed to the presence of unpaired nucleons. An analysis based on a one-dimensional penetration model that includes the effect of permanent quadrupolar deformations shows that the extracted values of the parameter β 2 follow the systematics established by the rest of the even samarium isotopes. The dependence of β 2 on the mass of the target nucleus indicates that the influence exerted by collective aspects upon the subbarrier fusion process increases rapidly as a function of the number of neutrons added to the spherical semimagic 144 Sm nucleus. (Author) [es

  2. Modified chemical synthesis of porous α-Sm{sub 2}S{sub 3} thin films

    Energy Technology Data Exchange (ETDEWEB)

    Kumbhar, V.S.; Jagadale, A.D. [Thin Film Physics Laboratory, Department of Physics, Shivaji University, Kolhapur, (M.S.) 416004 (India); Gaikwad, N.S. [Rayat Shikshan Sanstha, Satara, (M.S.) 415 001 (India); Lokhande, C.D., E-mail: l_chandrakant@yahoo.com [Thin Film Physics Laboratory, Department of Physics, Shivaji University, Kolhapur, (M.S.) 416004 (India)

    2014-08-15

    Highlights: • A novel chemical route to prepare α-Sm{sub 2}S{sub 3} thin films. • A porous honeycomb like morphology of the α-Sm{sub 2}S{sub 3} thin film. • An application of α-Sm{sub 2}S{sub 3} thin film toward its supercapacitive behaviour. - Abstract: The paper reports synthesis of porous α-Sm{sub 2}S{sub 3} thin films using modified chemical synthesis, also known as successive ionic layer adsorption and reaction (SILAR) method. The X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), atomic force microscopy (AFM), wettability and ultraviolet–visible spectroscopy (UV–vis) techniques are used for the study of structural, elemental, morphological and optical properties of α-Sm{sub 2}S{sub 3} films. An orthorhombic crystal structure of α-Sm{sub 2}S{sub 3} is resulted from XRD study. The SEM and AFM observations showed highly porous α-Sm{sub 2}S{sub 3} film surface. An optical band gap of 2.50 eV is estimated from optical absorption spectrum. The porous α-Sm{sub 2}S{sub 3} thin film tuned for supercapacitive behaviour using cyclic voltammetry and galvanostatic charge discharge showed a specific capacitance and energy density of 294 Fg{sup –1} and 48.9 kW kg{sup –1}, respectively in 1 M LiClO{sub 4}–propylene carbonate electrolyte.

  3. Formation of SmFe5(0001) ordered alloy thin films on Cu(111) single-crystal underlayers

    International Nuclear Information System (INIS)

    Yabuhara, Osamu; Ohtake, Mitsuru; Nukaga, Yuri; Futamoto, Masaaki; Kirino, Fumiyoshi

    2010-01-01

    SmFe 5 (0001) single-crystal thin films are prepared by molecular beam epitaxy employing Cu(111) single-crystal underlayers on MgO(111) substrates. The Cu atoms diffuse into the Sm-Fe layer and substitute the Fe sites in SmFe 5 structure forming an alloy compound of Sm(Fe,Cu) 5 . The Sm(Fe,Cu) 5 film is more Cu enriched with increasing the substrate temperature. The Cu underlayer plays an important role in assisting the formation of the ordered phase.

  4. First measurement of 153Sm in the SIR

    International Nuclear Information System (INIS)

    Michotte, C.; Ratel, G.; Lucas, L.

    1999-01-01

    In June 1998, the NIST sent to the International Reference System (SIR) a solution of 153 Sm standardized in a 4π ionization chamber. As this radionuclide had not previously been measured in the SIR, the resulting equivalent activity A e,NIST is compared with the value calculated from the efficiency curve of the SIR. However, problems occurred owing to the presence of 154 Eu and 156 Eu impurities in the solution. The manner in which the final equivalent activity value for this solution of 153 Sm has been deduced is described in this report. (authors)

  5. The neutron EDM in the SM: a review

    International Nuclear Information System (INIS)

    Dar, Shahida

    2000-08-01

    We review the status of the electric dipole moment (EDM) of neutron in the Standard Model (SM). The contributions of the strong and electroweak interactions are discussed separately. In each case the structure of Lagrangian and the sources of CP violation are specified, and subsequently calculational details are given. These two contributions to the neutron EDM exist in any extension of the SM including supersymmetry, two-doublet models as well as models with more than three generations of fermions. We briefly discuss the status of the neutron EDM in such extensions and give the relevant literature. (author)

  6. EFECTIVIDAD Y EFICIENCIA DE LOS ANTIVIRUS GRATUITOS COMBINADOS FRENTE AL MALWARE

    Directory of Open Access Journals (Sweden)

    Marlon Renné Navia Mendoza

    2015-06-01

    Full Text Available El estudio consistió en evaluar cuatro antivirus gratuitos con el objetivo de observar su rendimiento y carga de trabajo producida, tanto de forma individual como de forma combinada, al momento de proteger un computador contra el malware, para determinar qué tan conveniente es utilizar más de un antivirus a la vez. Para este proceso, se utilizó computadores con S.O. Windows 7 Profesional de 64 bits con varios programas utilitarios de uso común. Los aspectos considerados en la evaluación fueron: la carga de trabajo en el sistema, la protección ante amenazas y la utilidad en general. Se emplearon utilidades adicionales, como AppTimer o BootRacer para medir los parámetros de funcionamiento del software instalado en el computador. Los resultados obtenidos han permitido inferir la eficiencia de los antivirus tanto de forma individual y combinada, con la diferencia que la segunda modalidad requiere más recursos.

  7. Caracterización del sacrificio de corderos de pelo a partir de cruces con razas criollas colombianas

    Directory of Open Access Journals (Sweden)

    William Albarracín H.

    2013-03-01

    Full Text Available Objetivo. Evaluar el efecto genético del cruce de corderos Dorper con razas criollas colombianas, tiempo de ayuno y aturdimiento sobre los rendimientos del sacrificio; niveles de glucosa como medida de estrés y pH como calidad de la canal. Materiales y métodos. Se emplearon 60 corderos raza Dorper X criollo criados en pastoreo y semi-estabulación con 10 semanas de edad. Se aplicaron 3 tiempos de ayuno (6, 12 y 18 horas y 2 métodos de aturdimiento (electronarcosis y perno cautivo penetrante, evaluando los rendimientos de canal por pesaje de canales; glucosa en muestras antemortem y postmortem. Resultados. Los resultados obtenidos mostraron que el efecto combinado de ayuno y sistema de cría influencian los rendimientos de canal y subproductos. A tiempos prolongados de ayuno se aumenta la concentración de glucosa en sangre, aunque el tiempo de ayuno incide sobre el pH último. El efecto del aturdimiento, solo se presenta en el cambio de pH durante 24 horas, siendo un efecto de estimulación eléctrica por parte de la electronarcosis. Los animales de raza Dorper x criollo criados en sistema de pastoreo, presentaron mejores rendimientos en canal, pero menores porcentajes de vísceras blancas y rojas. Conclusiones. El porcentaje medio de rendimiento en canal es similar a los presentados en razas puras Dorper siendo viable y comparable este tipo de cruce.

  8. Sm-Nd isotope system of oldest granulites of Anabar Shield

    International Nuclear Information System (INIS)

    Spiridonov, V.G.; Sukhanov, M.K.; Karpenko, S.F.; Lyalikov, A.V.; AN SSSR, Moscow

    1991-01-01

    The first results of applying Sm-Nd method for dating the oldest basic and ultrabasic rocks of the Anabar Shield are presented. The content and isotopic composition of Sm and Nd were determined by the methods of mass-spectroscopy with isotopic dilution. The obtained values of metamorphic ages (3063 ± 80 million years) are in good agreement with U-Pb method data for zircon

  9. Microstructure and corrosion resistance of Sm-containing Al-Mn-Si-Fe-Cu alloy

    Directory of Open Access Journals (Sweden)

    Han Yuyin

    2017-12-01

    Full Text Available Optimizing alloy composition is an effective way to improve physical and chemical properties of automobile heat exchanger materials.A Sm-containing Al-Mn-Si-Fe-Cu alloy was investigated through transmission electron microscopy,scanning electron microscopy,and electrochemical measurement.Experimental results indicated that main phases distributed in the alloy wereα-Al(Mn,FeSi,Al2Sm and Al10Cu7Sm2.Alloying with Sm element could refine the precipitated α-Al(Mn,FeSi phase.Polarization testing results indicated that the corrosion surfacewas mainly composed of pitting pits and corrosion products.Sea water acetic acid test(SWAAT showed that corrosion loss increased first and then slowed downwith increase of the corrosion time.

  10. Formation of hydroxyl radical (sm-bulletOH) in illuminated surface waters contaminated with acidic mine drainage

    International Nuclear Information System (INIS)

    Allen, J.M.; Lucas, S.; Allen, S.K.

    1996-01-01

    Formation rates and steady-state concentrations of hydroxyl radical ( sm-bullet OH) in illuminated surface water samples collected in west-central Indiana that receive acidic mine drainage runoff are reported. Formation rates for sm-bullet OH in samples were measured by the addition of 1 x 10 -3 M benzene prior to illuminate in order to effectively scavenge all of the sm-bullet OH formed, thereby yielding phenol. The sm-bullet OH formation rates were calculated from the measured phenol formation rates. Steady-state concentrations of sm-bullet OH were measured by the addition of 5 x 10 -7 M nitrobenzene to the samples prior to illumination. Estimated sunlight sm-bullet OH formation rates range from 16 microM h -1 to 265 microM h -1 . Estimated sunlight steady-state sm-bullet OH concentrations range from 6.7 x 10 -15 to 4.0 x 10 -12 M. Both the formation rates and steady-state concentrations for sm-bullet OH are thus two to three orders of magnitude higher than values reported in the literature for other sunlit surface water samples. Due to the very high rates of formation and steady-state concentrations for sm-bullet OH in these samples, the authors conclude that aqueous-phase reactions involving sm-bullet OH represent a significant pathway by which organic pollutants in illuminated surface waters receiving acidic mine drainage runoff may be consumed

  11. Preparation of Sm3H7 nanoparticles and their application in ammonia synthesis

    International Nuclear Information System (INIS)

    Liu Tong; Zhang Yaohua; Li Xingguo

    2006-01-01

    Sm 3 H 7 nanoparticles have been successfully produced by hydrogen plasma-metal reaction (HPMR) method, and then used to synthesize ammonia at 298 K and 1 atm. The morphologies of the Sm 3 H 7 nanoparticles before and after reaction were investigated by transmission electron microscopy, and the crystal structures at different steps by X-ray diffraction. Nessler's test was adopted to detect ammonia. It was found that the passivated Sm 3 H 7 nanoparticles possess polyhedron shape and smooth surface, with the average size of about 50 nm and the specific surface area 11.2 m 2 g -1 . It was proposed that Sm 3 H 7 nanoparticles react with oxygen and nitrogen to form ammonia, but ammonia production is not observable in the case of coarse particles. After ammonia synthesis, the morphology of Sm 3 H 7 nanoparticles changes into spongy surface and the mean particle size and specific surface area increase to 100 nm and 28.6 m 2 g -1 , respectively, due to the release of hydrogen. The hydrogen conversion percentage from samarium hydride is estimated to be 1.5%. Without O 2 , Sm 3 H 7 nanoparticles cannot react with N 2 or N 2 + H 2 at 298 K and 1 atm

  12. Exopolysaccharides play a role in the swarming of the benthic bacterium Pseudoalteromonas sp. SM9913

    Directory of Open Access Journals (Sweden)

    Ang eLiu

    2016-04-01

    Full Text Available Most marine bacteria secrete exopolysaccharide (EPS, which is important for bacterial survival in the marine environment. However, it is still unclear whether the self-secreted EPS is involved in marine bacterial motility. Here we studied the role of EPS in the lateral flagella-driven swarming motility of benthic bacterium Pseudoalteromonas sp. SM9913 (SM9913 by a comparison of wild SM9913 and ΔepsT, an EPS synthesis defective mutant. Reduction of EPS production in ΔepsT did not affect the growth rate or the swimming motility, but significantly decreased the swarming motility on a swarming plate, suggesting that the EPS may play a role in SM9913 swarming. However, the expression and assembly of lateral flagella in ΔepsT were not affected. Instead, ΔepsT had a different swarming behavior from wild SM9913. The swarming of ΔepsT did not have an obvious rapid swarming period, and its rate became much lower than that of wild SM9913 after 35 h incubation. An addition of surfactin or SM9913 EPS on the surface of the swarming plate could rescue the swarming level. These results indicate that the self-secreted EPS is required for the swarming of SM9913. This study widens our understanding of the function of the EPS of benthic bacteria.

  13. Los cementos de ionómero vítreo de alta viscosidad para el éxito del tratamiento restaurador atraumático.

    OpenAIRE

    Brain Lascano, Laura C.

    2016-01-01

    Objetivo: Evaluar mediante un estudio in vitro las propiedades: Resistencia Compresiva (RC), Resistencia Flexural (RF), Resistencia al Desgaste (RD), Rugosidad Superficial (RS), Dureza Vickers (HV) y Remineralizacion de los Tejidos Adyacentes (RTA), de diversos CIV de alta viscosidad usados en el TRA con diversos materiales de recubrimiento superficial. Materiales y Métodos: Se analizaron 5 CIV: EQUIA FIL, Fuji IX, Ketac Molar Easymix, Ionofil Molar, Vitremer, combinados con diferen...

  14. Functional organization of the Sm core in the crystal structure of human U1 snRNP.

    Science.gov (United States)

    Weber, Gert; Trowitzsch, Simon; Kastner, Berthold; Lührmann, Reinhard; Wahl, Markus C

    2010-12-15

    U1 small nuclear ribonucleoprotein (snRNP) recognizes the 5'-splice site early during spliceosome assembly. It represents a prototype spliceosomal subunit containing a paradigmatic Sm core RNP. The crystal structure of human U1 snRNP obtained from natively purified material by in situ limited proteolysis at 4.4 Å resolution reveals how the seven Sm proteins, each recognize one nucleotide of the Sm site RNA using their Sm1 and Sm2 motifs. Proteins D1 and D2 guide the snRNA into and out of the Sm ring, and proteins F and E mediate a direct interaction between the Sm site termini. Terminal extensions of proteins D1, D2 and B/B', and extended internal loops in D2 and B/B' support a four-way RNA junction and a 3'-terminal stem-loop on opposite sides of the Sm core RNP, respectively. On a higher organizational level, the core RNP presents multiple attachment sites for the U1-specific 70K protein. The intricate, multi-layered interplay of proteins and RNA rationalizes the hierarchical assembly of U snRNPs in vitro and in vivo.

  15. Síndrome metabólico y factores de riesgo asociados con el estilo de vida de adolescentes de una ciudad de Argentina, 2005 Metabolic syndrome and risk factors associated with life style among adolescents in a city in Argentina, 2005

    Directory of Open Access Journals (Sweden)

    Williams Pedrozo

    2008-09-01

    Full Text Available OBJETIVOS: Determinar la prevalencia de síndrome metabólico (SM en adolescentes de una ciudad argentina y establecer su asociación con algunos factores de riesgo vinculados con el estilo de vida. MÉTODOS: Estudio descriptivo transversal en una muestra representativa de 532 estudiantes de enseñanza secundaria de 11 a 20 años (promedio: 15,3 años; mujeres: 60,0% de la ciudad de Posadas, Misiones, Argentina, entre julio y octubre de 2005. Se realizaron encuestas personales y sobre hábitos alimentarios, mediciones antropométricas, pruebas de sedentarismo, mediciones de la tensión arterial y pruebas de laboratorio. Se diagnosticó SM si se presentaban tres o más de las siguientes condiciones: glucemia > 110 mg/dL, triglicéridos > 110 mg/dL, colesterol de HDL percentil 90 y circunferencia de la cintura > percentil 90. RESULTADOS: La prevalencia de SM fue de 4,5%; significativamente mayor en varones que en mujeres (7,5% frente a 2,5%; P = 0,006 y en el grupo de 15 a 20 años que en el de 11 a 14 años (6,3% frente a 2,5%; P = 0,037. De los adolescentes, 44,7% tenía uno o más componentes del SM. El riesgo de los adolescentes con obesidad de padecer SM fue elevado (OR = 119,73; IC95%: 27,6 a 519,41. Los hábitos alimentarios y la frecuencia de consumo de alimentos fueron similares en los estudiantes con SM y sin SM, pero los primeros consumían alimentos obesogénicos con mayor frecuencia. Del total de adolescentes de la muestra, 84,8% eran sedentarios (100% de los que tenían SM. CONCLUSIONES: En Posadas, unos 1 400 estudiantes padecerían de SM y alrededor de 13 000 tendrían al menos un componente del SM. Se necesitan programas conjuntos del Estado y la comunidad para modificar los hábitos alimentarios y aumentar la actividad física, principalmente en varones, el grupo de 15-20 años y los obesos, para revertir esta situación y reducir la morbimortalidad derivada del SM.OBJECTIVES: To determine the prevalence of metabolic syndrome

  16. Negative pressure driven phase transformation in Sr doped SmCoO₃.

    Science.gov (United States)

    Arshad Farhan, M; Javed Akhtar, M

    2010-02-24

    Atomistic computer simulation techniques based on energy minimization procedures are utilized for the structural investigation of perovskite-type SmCoO(3). A reliable potential model is derived which reproduces both cubic as well as orthorhombic phases of SmCoO(3). We observe a negative chemical pressure induced structural phase transformation from distorted perovskite (orthorhombic) to perfect perovskite (cubic) due to the substitution of Sr(2 + ) at the Sm(3 + ) sites. However, external hydrostatic pressure shows isotropic compression and no pressure-induced structural transformation is observed up to 100 GPa. To maintain the electroneutrality of the system, charge compensation is through oxygen vacancies which results in the brownmillerite-type structure. A defect model is proposed, which is consistent with experimental results. The solution energies for divalent and trivalent cations are also calculated. These results show that the cations having ionic radii less than 0.75 Å will occupy the Co sites and those with ionic radii larger than 0.75 Å will substitute at the Sm sites.

  17. ANÁLISIS DE ESTABILIDAD DE HÍBRIDOS EXPERIMENTALES DE MAÍZ CON ALTA CALIDAD DE PROTEÍNA EN COSTA RICA

    Directory of Open Access Journals (Sweden)

    Nevio Bonilla-Morales

    2012-01-01

    Full Text Available El objetivo de este trabajo fue determinar la adaptación de híbridos experimentales de maíz en Costa Rica. Se evaluaron veinticuatro híbridos experimentales de grano blanco en las condiciones agroecológicas de bosque tropical húmedo, durante el período 2009-2011, en las localidades de Concepción, Guagaral, Chánguena, El Águila, Veracruz, Los Chiles y Upala, con temperaturas entre 26 y 35°C y una precipitación entre los 2700-3200 mm, esto con el fin de obtener el rendimiento y respuesta a los principales factores abióticos y bióticos. Se empleó un diseño de alfa látice con tres repeticiones. Los híbridos fueron evaluados en dos ciclos de siembra por localidad y por año. Los resultados del análisis combinado indicaron diferencias significativas al 0,05 entre genotipos y el gráfico del AMMI-biplot evidenció que los materiales con mayor estabilidad fueron: CLQRCWQ121/CLQRCWQ122//CML491 (QPM; CML494/CML495 (Normal; (CLQRCWQ121/CLQRCWQ26//CML491 (QPM; (CLQRCWQ121/CML502//CML491 (QPM con rendimientos promedio de 9,3; 9,0; 8,7 y 8,8 t/ha, respectivamente. Las localidades donde se obtuvo mayor rendimiento fueron El Águila y Guagaral, 9,8 y 8,5 t/ha, respectivamente. En cuanto a la interacción de localidades y genotipos el AMMI biplot mostró que El Águila y Guagaral tuvieron condiciones agroclimáticas más favorables para la expresión del potencial de los híbridos evaluados. Por su parte, Veracruz y Concepción presentaron condiciones agroclimáticas menos favorables para el desempeño de los materiales. La interacción genotipo x ambiente tuvo un valor de 62,1% en la prueba de Gollob.

  18. Multiple magnetic transitions in SmCoAsO

    Directory of Open Access Journals (Sweden)

    Yongliang Chen

    2011-12-01

    Full Text Available The magnetic properties of SmCoAsO have been investigated. Our results differ from early observations. Complicated magnetism consists of antiferromagnetic, ferromagnetic, ferrimagnetic and paramagnetic, even diamagnetism at low field has been observed. A metamagnetic transition was observed, resulting from a canting of the spins. The interaction between two Co sublattices with canted-structure might take responsibility for the multiple magnetic transitions. Electrical resistivity data indicate that SmCoAsO is metallic conductor with room temperature resistivity of 0.51669 mΩ-cm. Negative magnetoresistance effect suggests a significant suppression of spin-flip scattering by the applied magnetic field. The magnetic phase diagram has been established.

  19. Complexation of 188Re-phosphonates: in vitro and in vivo studies

    International Nuclear Information System (INIS)

    Faintuch, B.L.; Muramoto, E.; Faintuch, S.

    2003-01-01

    MDP (methylenediphosphonate) and HEDP (hydroxyethylidene diphosphonate), both disphosphonates, and EDTMP (ethylenediamine tetramethylene phosphonic acid), a tetraphosphonate ligand, have been previously labeled with 188 Re for use in metastatic bone-pain palliation. The aim of this study was a comparison between the three complexes 188 Re-MDP, 188 Re-HEDP and 188 Re-EDTMP concerning the complexation conditions, in order to achieve maximum yield, stability and bone uptake. Methods: MDP was dissolved in water and HEDP and EDTMP were dissolved in NaOH 1 N followed by reduction of pH with HCl 1 N. To all mixtures stannous chloride and 188 ReO 4 - were added in a nitrogen atmosphere. The preparations were heated in boiling water bath for 15 min. Yield as well as radiochemical stability was estimated by ITLC. Different concentrations of phosphonates and stannous chloride were evaluated. Biodistribution studies in Swiss mice were done for the three 188 Re-phosphonates that presented the best radiochemical yield. The optimal ligand concentration for maximum complexation was 85.2 mM for MDP, 72.8 mM for HEDP and 45.8 mM for EDTMP. The best amount of SnCl 2 .2H 2 O was 1.5 mg/mL for 188 Re-HEDP and 1 mg/mL for both 188 Re-MDP and 188 Re-EDTMP. In these conditions the three complexes showed a complexation rate above 95%. Reasonable radiochemical stability for 24 hours was achieved by 188 Re-EDTMP when employing ascorbic acid. All products showed a great uptake by the kidneys. 188 Re-EDTMP had the greatest uptake by femur (3.1 ± 0.2% ID/g) followed by 188 Re-MDP (1.2 ± 0.1% ID/g) and 188 Re-HEDP (1.0 ± 0.1% ID/g), 4 hours post injection. 188 Re-EDTMP displayed a femur bone/muscle ratio of 28.5, 188 Re-MDP 4.9 and 188 Re-HEDP 4.9. In conclusion 188 Re-EDTMP demonstrated the best potential as a radiopharmaceutical for bone cancer pain relief, encouraging further dosimetric studies and clinical trials. (orig.)

  20. Autophagic kinases SmVPS34 and SmVPS15 are required for viability in the filamentous ascomycete Sordaria macrospora.

    Science.gov (United States)

    Voigt, Oliver; Herzog, Britta; Jakobshagen, Antonia; Pöggeler, Stefanie

    2014-01-01

    Autophagy is a tightly controlled degradation process of all eukaryotes. It includes the sequestration of cytoplasmic contents and organelles within a double-membraned autophagosome. Autophagy involves core autophagy related (atg) genes as well as genes regulating vesicle trafficking. Previously, we analyzed the impact of proteins of the core autophagic machinery SmATG7, SmATG8 and SmATG4 on the sexual and vegetative development of the filamentous ascomycete Sordaria macrospora. While deletion of Smatg8 and Smatg4 abolished fruiting-body formation and impaired vegetative growth, Smatg7 is required for viability. In yeast, the phosphatidylinositol 3-kinase vacuolar protein sorting 34 (Vps34) and its myristoylated membrane targeting unit, the protein kinase Vps15 have been shown to be important regulators of autophagy and vacuolar protein sorting. However, their exact role in filamentous ascomycetes remains elusive. To determine the function of Smvps34 and Smvps15 we isolated genes with high sequence similarity to Saccharomyces cerevisiae VPS34 and VPS15. For both genes we were not able to generate a homokaryotic knockout mutant in S. macrospora, suggesting that Smvps34 and Smvps15 are required for viability. Furthermore, we analyzed the repertoire of vps genes encoded by S. macrospora and could identify putative homologs of nearly all of the 61 VPS genes of S. cerevisiae. Copyright © 2013 Elsevier GmbH. All rights reserved.

  1. Enfoque terapéutico en 154 pacientes con acromegalia Therapeutic management in 154 acromegalic patients

    Directory of Open Access Journals (Sweden)

    Marcos P. Manavela

    2010-08-01

    Full Text Available La acromegalia es una enfermedad poco frecuente producida en más del 95% de los casos por un tumor hipofisario secretor de hormona de crecimiento (GH. Las manifestaciones clínicas están asociadas a síntomas locales por crecimiento del tumor o a las consecuencias orgánicas y metabólicas secundarias a la hipersecreción de GH. Debido a la alta morbilidad y mortalidad asociadas a la acromegalia, un tratamiento individualizado y optimizado para cada paciente es fundamental. Informamos el enfoque terapéutico de nuestro servicio de endocrinología en la atención de 154 pacientes con acromegalia. Utilizando criterios bioquímicos estrictos, con la cirugía logramos un 32% de remisión global, tasa relativamente baja debido fundamentalmente a que la mayor parte de los pacientes presentaban macroadenomas con un alto porcentaje de invasividad local. Con radioterapia complementaria o como tratamiento inicial se logró la remisión en el 65.4% de los pacientes irradiados. El 14.0% de los pacientes controlaron la enfermedad utilizando agonistas dopaminérgicos solos o combinados con otra droga, mientras que aquellos que utilizaron análogos de la somatostatina normalizaron los parámetros bioquímicos en un 45.7% de los casos. En conclusión, con los diferentes tratamientos utilizados obtuvimos el control de la acromegalia en el 55.2% de los casos, esperando optimizar el tratamiento de estos pacientes en la medida en que contemos con y tengamos acceso a nuevas herramientas terapéuticas.Acromegaly is a chronic, invalidating disease due in over 95% of cases to a growth hormone (GH secreting pituitary adenoma. Its clinical manifestations are associated to local complications related to the tumor growth and/or to the metabolic consequences of GH excess. We report here our experience on 154 acromegalic patients. Surgical remission rate using stringent biochemical criteria was 32%, a figure relatively low due to the great number of patients bearing

  2. Giant magnetic coercivity in YNi{sub 4}B-type SmNi{sub 3}TB (T=Mn–Cu) solid solutions

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Jinlei; Yan, Chang [Research Center for Solid State Physics and Materials, School of Mathematics and Physics, Suzhou University of Science and Technology, Suzhou 215009 (China); Yapaskurt, V.O. [Department of Petrology, Geological Faculty Moscow State University, Leninskie Gory, Moscow 119992 (Russian Federation); Morozkin, A.V., E-mail: morozkin@tech.chem.msu.ru [Department of Chemistry, Moscow State University, Leninskie Gory, House 1, Building 3, GSP-2, Moscow 119992 (Russian Federation)

    2016-12-01

    The effects of transition metal substitution for Ni on the magnetic properties of the YNi{sub 4}B-type SmNi{sub 4}B via SmNi{sub 3}TB (T=Mn, Fe, Co, Cu) solid solutions have been investigated. SmNi{sub 4}B, SmNi{sub 3}MnB, SmNi{sub 3}FeB, SmNi{sub 3}CoB and SmNi{sub 3}CuB show ferromagnetic ordering at 40 K, 210 K, 322 K, 90 K and 57 K and field sensitive metamagnetic-like transitions at 15 K, 100 K, 185 K, 55 K and 15 K in a magnetic field of 10 kOe, respectively. The magnetocaloric effects of SmNi{sub 3}TB (T=Mn–Cu) were calculated in terms of isothermal magnetic entropy change (ΔS{sub m}). The magnetic entropy ΔS{sub m} reaches value of –0.94 J/kg K at 40 K for SmNi{sub 4}B, –1.5 J/kg K at 205 K for SmNi{sub 3}MnB, –0.54 J/kg K at 320 K for SmNi{sub 3}FeB, –0.49 J/kg K at 90 K for SmNi{sub 3}CoB and –0.54 J/kg K at 60 K for SmNi{sub 3}CuB in field change of 0–50 kOe around the Curie temperature. They show positive ΔS{sub m} of +0.71 J/kg K at ~10 K for SmNi{sub 4}B, +1.69 J/kg K at 30 K for SmNi{sub 3}MnB, +0.89 J/kg K at 110 K for SmNi{sub 3}FeB, +1.08 J/kg K at 25 K for SmNi{sub 3}CoB and +1.12 J/kg K at 10 K for SmNi{sub 3}CuB in field change of 0–50 kOe around the low temperature metamagnetic-like transition. Below the field induced transition temperature (change of magnetic structure), SmNi{sub 3}TB (T=Mn–Cu) exhibits giant magnetic coercivity of 74 kOe at 5 K for SmNi{sub 4}B, 69 kOe at 20 K (90 kOe at 10 K) for SmNi{sub 3}MnB, 77 kOe at 60 K for SmNi{sub 3}FeB, 88 kOe at 20 K for SmNi{sub 3}CoB and 52 kOe at 5 K for SmNi{sub 3}CuB. - Highlights: • YNi{sub 4}B-type SmNi{sub 3}{Mn, Fe, Co, Ni, Cu}B exhibit the Curie points at 39–322 K. • SmNi{sub 3}{Mn, Fe, Co, Ni, Cu}B show field induced transition at 15–185 K. • SmNi{sub 3}MnB shows huge magnetic hysteresis with coercive field of 69 kOe at 20 K. • SmNi{sub 3}FeB shows huge magnetic hysteresis with coercive field of 77 kOe at 60 K. • SmNi{sub 3}CoB shows giant coercive

  3. Complexes of Sm(III) and Dy(III) with piperazines

    Energy Technology Data Exchange (ETDEWEB)

    Manhas, B S; Trikha, A K [Punjabi Univ., Patiala (India). Dept. of Chemistry; Singh, M [Guru Nanak Dev Univ., Amritsar (India). Dept. of Chemistry

    1981-09-01

    Complexes of SmCl/sub 3/, DyCl/sub 3/, Sm(NO/sub 3/)/sub 3/ and Dy(NO/sub 3/) with piperazine, N-methylpiperazine, 2-methylpiperazine, N-phenyl-piperazine and N, N'-dimethyl-piperazine have been prepared and characterized on the basis of elemental analyses, IR and electronic reflectance spectra and magnetic susceptibility measurements. IR data indicate that the ligands are coordinated in the chair conformation giving polymeric bridged complexes and that the nitrate group is bidentate. Coordination numbers from 6 to 12 are proposed for the lanthanide ions.

  4. Tratamiento con azlocillin y amikacina en sepsis neonatal por staphylococcus haemolyticus multirresistente

    Directory of Open Access Journals (Sweden)

    María Espino Hernández

    2000-03-01

    Full Text Available El estafilococo coagulasa negativa es actualmente un importante patógeno nosocomial y agente causal de infección en el neonato. Cepas multirresistentes comúnmente aisladas de recién nacidos sometidos a cuidados intensivos dificultan la terapéutica, por lo que se hace necesario el empleo de combinaciones antibióticas que garanticen un efecto antibacteriano más eficiente. Se presentan los resultados obtenidos en un paciente con bronconeumonía adquirida por Staphylococcus haemolyticus multirresistente y que fue sometido a tratamiento combinado de azlocillin y amikacina. Se estudió el patrón de resistencia de la cepa para 30 antibióticos por métodos de difusión y dilución, así como la efectividad in vitro de la combinación antibiótica aplicada por el método del «tablero de ajedrez». Se observó en los resultados in vitro una marcada potencialización de la actividad aminoglucosídica por la presencia del antibiótico beta-lactámico, resultado que se correspondió con una excelente respuesta in vivo.Negative-coagulase Staphyloccocus, is at present time an important nosocomial pathogen and a causal agent of neonatal infection. Multirresistant strains commonly isolated from newborn under intensive care, make difficult treatment, so it is necessary use of antibiotic combination to assure a more efficient antibacterial effect. We present results obtained in a patient presenting with acquired bronchopneumonia from multirresistant Staphylococcus haemolyticus who received a combination of Azlocillin and Amikacin. Resistance pattern to this strain was studied by diffusion and dilution methods, as well as in vitro effectiveness of antibiotic combination, applied by "Chequerboard" method. In in vitro results, we found a significant potentiation of aminoglucoside activity by presence of Beta-lactamic antibiotic, result corresponding to an in vivo excellent response.

  5. Bioactivity assays and application of 125I labeled human mouse chimeric anti-CD22 monoclonal antibody SM03

    International Nuclear Information System (INIS)

    Lu Pingping; Meng Zhiyun; Dou Guifang; Wu Yingliang; Wang Minwei

    2008-01-01

    To investigate the bioactivity and application of 125 I labeled human mouse chimeric monoclonal SM03, SM03 was labeled with 125 I using Indogen method. The labeled mixture was purified by Sephacryl S-300 HR separation chromospectry. The purity and concentration of separated fractions were determined by HPLC and Protein Assay Kit, respectively. Competitive binding method and ELISA method were used for bioactivity assays. 125 I-SM03 was applied to screen cell lines which express the most abundant CD22 antigen. The purity and recovery of 125 I-SM03 were >99% and >47%, respectively. The bioactivity of 125 I- SM03 and SM03 hasn't significant difference in statistics. Ramos cell line had the strongest special radioactivity when 125 I-SM03 bound with in Raji, Daudi and Ramos cell lines. Indogen method is a good way to label Human mouse chimeric anti-CD22 monoclonal antibody SM03 and the label will not affect the activity of SM03. The 125 I-SM03 not only can be used for detect agent, but also may be put into market for NHL therapy. (authors)

  6. Phase evolution and its effects on the magnetic performance of nanocrystalline SmCo7 alloy

    International Nuclear Information System (INIS)

    Zhang Zhexu; Song Xiaoyan; Xu Wenwu

    2011-01-01

    The evolution of the phase constitution and the microstructure, as well as their effects on magnetic performance, were investigated systematically using a prepared nanocrystalline single-phase SmCo 7 alloy as the starting material for a series of annealing processes. The SmCo 7 (1:7 H) phase was discovered to have a good single-phase stability from room temperature up to 600 deg. C. The destabilization of the SmCo 7 phase results in the formation of the Sm 2 Co 17 (2:17 R) and SmCo 5 (1:5 H) phases, which exist as phase-transformation twins and particulate precipitates, respectively, with a completely coherent relationship with the 1:7 H parent phase. For the first time the formation mechanism of the 2:17 R phase-transformation twins has been proposed, in which the ordered substitution of 1/3 of the Sm atoms by Co-Co dumbbell pairs along two particular crystal directions was demonstrated. The characteristic width values of the 2:17 R phase-transformation twins, as deduced from this model of the mechanism, were unambiguously verified by the experimental results. Among the SmCo 7 alloys with various phase constitutions and microstructures, the best magnetic properties were obtained in the nanocrystalline 1:7 H single-phase alloys. The present work may promote a new understanding of nanoscale-stabilized single-phase SmCo 7 and its potential applications as unique high-temperature permanent magnets.

  7. Falla cardiaca, tratamiento: diuréticos, inhibidores de la ECA y nitratos

    OpenAIRE

    Guillermo Trout Guardiola

    2013-01-01

    En los pasados 15 años grandes ensayos clínicos randomizados, controlados, han revolucionado el manejo de pacientes con falla cardiaca. Aunque es claro que algunas drogas mejoran los síntomas, otras presentan beneficios pronósticos y sintomáticos, el manejo de falla cardiaca se debe centralizar en mejorar la calidad de vida y la sobrevida. Los diuréticos y los inhibidores de la enzima convertidora de la angiotensina, combinados con medidas no farmacologicas, permanecen como el tratamiento con...

  8. Study on irradiation conditions of producing 153Sm with natural abundance samarium target

    International Nuclear Information System (INIS)

    Du Jin; Jin Xiaohai; Bai Hongsheng; Liu Yuemin; Chen Daming; Wang Fan

    1998-01-01

    Irradiation conditions of natural abundance 152 Sm targets in different forms are studied in the heavy water reactor and the light water swimming pool reactor at the China Institute of Atomic Energy. The result shows that the specific activity of 153 Sm in liquid form target irradiated in the light water swimming pool reactor is two times greater than that in solid form target. The radionuclide purity of 153 Sm is more than 99%, which can meet the needs of clinical application

  9. Enhanced Photoluminescence of Sm3+/Bi3+ Co-Doped La2O3 Nanophosphors by Combustion Synthesis

    Science.gov (United States)

    Zhang, Ying; Wu, Muying; Zhang, W. F.

    Nanosized La2O3:Sm3+ and La2O3:Sm3+, Bi3+ phosphor powders were prepared via combustion synthesis. The structures and morphology were examined using powder X-ray diffraction and transmission electron microscope, respectively. The photoluminescence spectra were investigated at different doping concentrations of Sm3+ and Bi3+ ions. The results indicate that La2O3:Sm3+ (Bi3+) exhibited good crystallinity and spherical-like particles. All phosphors give emission bands centered at 564, 608 and 650 nm corresponding to 4G5/2→6HJ (J=5/2, 7/2 and 9/2) transitions of Sm3+ ions, respectively. Interestingly, the emission intensity of Sm3+ ions is significantly enhanced with the addition of Bi3+ ions to La2O3:Sm3+ and the maximum occurs at a Bi3+ concentration of 0.8 mol%. The La2O3:Sm3+, Bi3+ phosphor with highly enhanced luminescence is very encouraging for applications in display and tunable solid lasers.

  10. Photoluminescence properties of a new orange-red-emitting Sm(3+)-La3SbO7 phosphor.

    Science.gov (United States)

    Li, Zeng-Mei; Deng, Li-Gang; Zhao, Shan-Cang; Zhang, Shu-Qiu; Guo, Chang-Ying; Liang, Jing-Yun; Yue, Hui; Wan, Chun-Yan

    2016-03-01

    The antimonate compound La3SbO7 has high chemical stability, lattice stiffness and thermal stability. Orange-red-emitting antimonate-based phosphors La3SbO7:xSm(3+) (x = 0.02, 0.05, 0.08, 0.10, 0.15, 0.20 and 0.25) were synthesized. The phase structure and photoluminescence properties of these phosphors were investigated. The emission spectrum obtained on excitation at 407 nm contained exclusively the characteristic emissions of Sm(3+) at 568, 608, 654 and 716 nm, which correspond to the transitions from (4)G5/2 to (6)H5/2, (6)H7/2, (6)H9/2 and (6)H11/2 of Sm(3+), respectively. The strongest emission was located at 608 nm due to the (4)G5/2→(6)H7/2 transition of Sm(3+), generating bright orange-red light. The critical quenching concentration of Sm(3+) in La3SbO7:Sm(3+) phosphor was determined as 10% and the energy transfer between Sm(3+) was found to be through an exchange interaction. The International Commission on Illumination chromaticity coordinates of the La3SbO7:0.10Sm(3+) phosphors are located in the orange-red region. The La3SbO7:Sm(3+) phosphors may be potentially used as red phosphors for white light-emitting diodes. Copyright © 2015 John Wiley & Sons, Ltd.

  11. Experimental cross section for the {sup 152}Sm(n, γ){sup 153}Sm reaction at 0.0334 eV

    Energy Technology Data Exchange (ETDEWEB)

    Uddin, M. Shuza; Datta, Tapash Kumar; Hossain, Syed Mohammod; Zakaria, A.K.M.; Islam, Mohammad Amirul; Naher, Kamrun; Shariff, M. Asad; Yunus, S.M. [Atomic Energy Research Establishment, Dhaka (Bangladesh). Inst. of Nuclear Science and Technology; Afroze, Nasmin [Atomic Energy Research Establishment, Dhaka (Bangladesh). Inst. of Nuclear Science and Technology; Jahangirnagar Univ., Dhaka (Bangladesh). Dept. of Physics; Islam, S.M. Ajharul [Jahangirnagar Univ., Dhaka (Bangladesh). Dept. of Physics

    2014-10-01

    The neutron capture cross section for the {sup 152}Sm(n, γ){sup 153}Sm reaction at an energy of 0.0334 eV was measured for the first time using monochromatic neutrons of a powder diffractometer at the TRIGA Mark II nuclear reactor at Dhaka, Bangladesh. The {sup 197}Au(n, γ){sup 198}Au reaction was used to monitor the neutron beam intensity. The radioactivity of the products was determined via high resolution γ-ray spectrometry. The obtained cross section value is 184 ± 22b, which is consistent with both the ENDF/B-VII and TENDL-2012 data libraries. The measured value at 0.0334 eV and the previous data at 0.0536 eV confirm the reliability of the data in the above libraries. (orig.)

  12. INTERACTION MODE BETWEEN METHYLENE BLUE-Sm(III ...

    African Journals Online (AJOL)

    Preferred Customer

    between methylene blue (MB)-Sm(III) complex and herring sperm DNA by using acridine orange .... the complex was recorded as KBr pellets on Spectrum One FTIR system (PE Company, USA), ..... mechanism of drugs and drug design.

  13. Formation of SmFe{sub 5}(0001) ordered alloy thin films on Cu(111) single-crystal underlayers

    Energy Technology Data Exchange (ETDEWEB)

    Yabuhara, Osamu; Ohtake, Mitsuru; Nukaga, Yuri; Futamoto, Masaaki [Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551 (Japan); Kirino, Fumiyoshi, E-mail: yabuhara@futamoto.elect.chuo-u.ac.j [Graduate School of Fine Arts, Tokyo National University of Fine Arts and Music, 12-8 Ueno-koen, Taito-ku, Tokyo 110-8714 (Japan)

    2010-01-01

    SmFe{sub 5}(0001) single-crystal thin films are prepared by molecular beam epitaxy employing Cu(111) single-crystal underlayers on MgO(111) substrates. The Cu atoms diffuse into the Sm-Fe layer and substitute the Fe sites in SmFe{sub 5} structure forming an alloy compound of Sm(Fe,Cu){sub 5}. The Sm(Fe,Cu){sub 5} film is more Cu enriched with increasing the substrate temperature. The Cu underlayer plays an important role in assisting the formation of the ordered phase.

  14. Investigations on optical properties of Sm3+ ion doped boro-phosphate glasses

    Science.gov (United States)

    Vijayakumar, R.; Suthanthirakumar, P.; Karthikeyan, P.; Marimuthu, K.

    2015-06-01

    The Sm3+ doped Boro-phosphate glasses with the chemical composition 60H3BO3+20Li2CO3+10ZnO+(10-x) H6NO4P+xSm2O3 (where x= 0.1, 0.5, 1 and 2 in wt%) have been prepared by melt quenching technique. The prepared glasses were characterized through optical absorption and luminescence spectral measurements. The band gap energies corresponding to the direct and indirect allowed transitions and the Urbach's energy values were estimated from the absorption spectra. Judd-Ofelt intensity parameters have been derived to predict the radiative properties of the various emission transitions. In order to identify the emission color of the prepared glasses, the emission intensities were analyzed using CIE 1931 color chromaticity diagram. The energy transfer process takes place between Sm3+-Sm3+ ions through cross-relaxation mechanism have also been investigated and the results were discussed and reported.

  15. Crystal structure of Sm(NO3)3x6H2O

    International Nuclear Information System (INIS)

    Espenbetov, A.A.; Gerr, R.G.; Struchkov, Yu.T.; Sal'nikova, N.A.; Akimov, V.M.; Odinets, Z.K.

    1985-01-01

    X-ray diffraction study of a salt, prepared when mixing concentrated nitric acid solutions of NaNO 3 and Sm(NO 3 ) 3 , has been carried out. It is established, that the salt is a concretion of two crystals: NaNO 3 and Sm(NO 3 ) 3 x6H 2 O (1). X-ray diffraction study of 1 is carried out (lambda Mo, diffractometer, 1511 reflections, the method of heavy atom, the least square method in anisotropic approximation up to R=0.0348). The crystals of 1 are triclinic: a=6.755, b=9.168, c=11.684 A, α=69.93, β=88.86, γ=69.28, Z=2, Fedorov group P anti 1. Symmetery of 10-vertex coordination polyhedron (CP) of Sm atom is close to Csub(s). Sm atom coordination can be described as 4;5:1. Four H 2 O molecules are included into CP, at the expense of two remaining H 2 O molecules CP are bound with each other

  16. Late gadolinium enhancement by magnetic resonance explains adverse cardiac events in individuals with ventricular arrhythmia; Realce tardío con gadolinio por resonancia magnética explica eventos cardíacos adversos en individuos con arritmia ventricular

    Energy Technology Data Exchange (ETDEWEB)

    Courtis, J.; Vasallo, J.; Arabia, L. [Departamento de Imágenes, Cardiología Intervencionista y Electrofisiología Instituto Oulton, Córdoba (Argentina); Dimitroff, M.; Gonzalez, A. [Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Códoba (Argentina); Tibaldi, M., E-mail: javiercourtis@oulton.com.ar [Técnicas no Invasivas y Arritmias, Instituto Modelo de Cardiología, Córdoba (Argentina)

    2012-07-01

    ) predice eventos cardíacos adversos en pacientes con arritmia ventricular. Métodos: se seleccionaron 74 pacientes consecutivos con arritmia ventricular sintomática (extrasístoles ventriculares y taquicardia ventricular) y fracción de eyección del ventrículo izquierdo (FEVI) >55% enviados a RMC para evaluación de cardiopatía estructural no detectada previamente por otros métodos complementarios. Se analizó el RTG, la función sistólica y los volúmenes de ambos ventrículos. En el seguimiento se evaluó un punto final combinado: hospitalización por arritmia ventricular, descarga apropiada de cardiodesfibrilador implantable y muerte cardíaca. Resultados: durante una mediana de seguimiento de 575 días (rango intercuartil 24-1120 días) y al analizar la población según tuvieran (n=9, 12%) o no (n=65, 88%) RTG se observó que el grupo con Gd positivo presentaba una FEVI menor (58% vs. 66% respectivamente, p=0.01) y volúmenes mayores (VTD: 185 ml vs. 123 ml respectivamente, p=0.01 y VTS: 81 ml vs. 42 ml respectivamente, p=0.01) que el otro grupo. Dos (22%) pacientes del grupo RTG positivo vs. 1 (4%) de aquellos sin RTG presentaron el punto final combinado (p=0.01) y al realizar un análisis de regresión logística se halló que el RTG es predictor de los eventos cardíacos adversos analizados (p=0.029). Conclusiones: en esta serie consecutiva de pacientes con arritmia ventricular demostramos una fuerte asociación entre el RTG miocárdico y eventos cardíacos adversos; esto soporta la hipótesis que la fibrosis miocárdica es un importante sustrato arritmogénico. Además, casi la totalidad de los individuos sin RTG estuvieron libres de eventos en el seguimiento sugiriendo que es posible identificar a través de la RMC sujetos de bajo riesgo los cuales pueden ser tratados conservadoramente. (autores)

  17. Coordinated control of a combined cycle thermoelectric central; Control coordinado de una central termoelectrica de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez Parra, Marino; Castelo Cuevas, Luis [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1998-03-01

    In this paper the coordinated control (CC) of the Distributed Control System (Sistema de Control Distribuido) (SICODI) of the Combined Cycle Central of Gomez Palacio, Durango, is presented. The description of the control scheme and its realization in software is made. From the scheme the operation strategies and automation, supervision and control are described in detail. The software components of the programming are described, the program structure and control data and its implementation in working stations VAX 3100 under the operating system VMS (Virtual Memory System), are described. [Espanol] En este articulo se presenta el control coordinado (CC) del Sistema de Control Distribuido (Sicodi) de la central de ciclo combinado Gomez Palacio, Durango. Se describe el esquema de control y su realizacion en software. Del esquema se detallan las estrategias de operacion y automatizacion, supervision y control. Del software se describen los componentes de la programacion, la estructura de programas y datos del control y su implementacion en estaciones de trabajo VAX 3100 bajo el sistema operativo VMS (Virtual Memory System).

  18. Origin of perpendicular magnetic anisotropy of SmCo5 thin films with Cu underlayer

    International Nuclear Information System (INIS)

    Sayama, Junichi; Mizutani, Kazuki; Asahi, Toru; Ariake, Jun; Ouchi, Kazuhiro; Osaka, Tetsuya

    2006-01-01

    Effects of the Cu underlayer thickness and the addition of Cu to a Sm-Co layer on magnetic properties and microstructure of SmCo 5 thin films exhibiting perpendicular magnetic anisotropy were studied. The origin of the perpendicular magnetic anisotropy was discussed from these experimental results. A thick Cu underlayer of more than 100 nm brought about high perpendicular magnetic anisotropy leading to the squareness ratio equal to unity. The Cu addition enhanced the perpendicular magnetic anisotropy and reduced the Cu underlayer thickness required to obtain the squareness ratio of unity. X-ray diffractometry showed that the crystalline orientation of the Sm-Co layer did not correlate with that of the Cu underlayer. Auger electron spectroscopy revealed that Cu atoms were diffused up to the Sm-Co layer from the Cu underlayer. From the results, Cu atoms existing in the Sm-Co layer were suggested to be strongly related with an appearance of the perpendicular magnetic anisotropy by introducing the Cu underlayer

  19. Recycling of SmCo5 magnets by HD process

    Science.gov (United States)

    Eldosouky, Anas; Škulj, Irena

    2018-05-01

    Hydrogen decrepitation process has been applied for the first time for the direct recycling of SmCo5 magnets. Industrially produced sintered SmCo5 magnets were decrepitated by hydrogen gas at a pressure of 1 bar to 9.5 bar at room temperature in a planetary rotating jar. After decrepitation, the starting sintered magnets were reduced to a powder with a particle size of less than 200 μm. The produced powder was used for the preparation of recycled SmCo5 magnets. Scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction studies and magnetic measurements were used to follow the decrepitation and the sintering processes. The measured remanence and maximum energy product of the recycled magnet are 0.94 T and 171.1 kJ/m3, respectively, in comparison with 0.91 T and 156.8 kJ/m3, respectively for the original magnet before recycling. It was also observed that, there is refinement in the microstructure after recycling in comparison to the original magnet.

  20. New NaSrPO4:Sm phosphor as orange-red emitting material

    Indian Academy of Sciences (India)

    Because NaSr1−xPO4:xSm3+ phosphor features a high colour-rendering index and chemical stability, it is potentially ... use blue LED chips (GaN or InGaN) with a yellow phosphor ... excitation by doping Sm3+ rare earth ions into a suitable.

  1. The Material Supply Adjustment Process in RAMF-SM, Step 2

    Science.gov (United States)

    2016-06-01

    I N S T I T U T E F O R D E F E N S E A N A L Y S E S The Material Supply Adjustment Process in RAMF-SM, Step 2 Eleanor L. Schwartz James S...5564 The Material Supply Adjustment Process in RAMF-SM, Step 2 Eleanor L. Schwartz James S. Thomason, Project Leader This page is intentionally blank...9 1. Inputs and Outputs .......................................................................................10 2. Specific Steps of the PEAP

  2. Polarized spectral properties of Sm3+:LiYF4 crystal

    International Nuclear Information System (INIS)

    Wang, G.Q.; Lin, Y.F.; Gong, X.H.; Chen, Y.J.; Huang, J.H.; Luo, Z.D.; Huang, Y.D.

    2014-01-01

    A trivalent samarium-doped LiYF 4 single crystal was grown by the vertical Bridgman technique. Its polarized absorption and fluorescence spectra and fluorescence decay curves were recorded at room temperature. On the basis of the Judd–Ofelt theory, the spectral parameters of the Sm 3+ :LiYF 4 crystal were calculated. The emission cross sections for the 4 G 5/2 → 6 H J (J=5/2, 7/2. 9/2, and 11/2) transitions of special interest for visible laser application were obtained by the Fuchtbauer–Ladenburg formula. -- Highlights: • Polarized spectral properties of Sm 3+ :LiYF 4 crystal at room temperature were analyzed in detail. • The emission cross sections for the transitions of special interest for visible laser application are calculated. • Sm 3+ :LiYF 4 is a promising laser material for 401 nm GaN LD pumped 605 nm visible laser

  3. Observation of dipole bands in 144Sm

    International Nuclear Information System (INIS)

    Raut, R.; Ganguly, S.; Kshetri, R.; Banerjee, P.; Bhattacharya, S.; Dasmahapatra, B.; Mukherjee, A.; Sahasarkar, M.; Goswami, A.; Basu, S.K.; Bhattacharjee, T.; Mukherjee, G.; Chakraborty, A.; Ghughre, S.S.; Krishichayan; Mukhopadhyay, S.; Gangopadhyay, G.; Singh, A.K.

    2007-01-01

    The nucleus 144 Sm (Z=62, N=82), with its proximity to the shell closure and possibilities of particles and holes occupying high j orbitals, following appropriate excitations, is a suitable system for observation of dipole (MR) bands

  4. Sm/Ti co-substituted bismuth ferrite multiferroics: reciprocity between tetragonality and piezoelectricity.

    Science.gov (United States)

    Jha, Pardeep K; Jha, Priyanka A; Singh, Prabhakar; Ranjan, Rajeev; Dwivedi, R K

    2017-10-04

    BiFeO 3 (BFO) systems co-modified with Ti, Sm and Sm-Ti have been investigated for piezoelectricity together with dielectric and multiferroic properties. Structural studies revealed the coexistence of orthorhombic and rhombohedral (R3c) phases for x > 0.12. Impurity phases were shown to have hardly any effect on the remanent magnetization, which rather depends on the Fe-O-Fe bond angle. The dielectric loss was reduced considerably by substitution. A correlation between the piezoelectric coefficient and tetragonality was observed in these samples. BFO co-substituted with Sm-Ti exhibited a high piezoelectric coefficient with better ferroic properties, which revealed a unique combination of green piezoelectricity and multiferroicity.

  5. Evaluation of the biological and scanning distribution of hydroxyapatite-153Sm radiotherapeutic agent

    International Nuclear Information System (INIS)

    Herrera, J.; Paredes, N.; Portilla, A.; Miranda, J.; Carrillo, D.

    1999-01-01

    Fixation of 153 Sm labeled hydroxyapatite (HA) in the synovial capsule and extra articular localization were evaluated by means of biological distribution tests and gamma scanning studies. These were carried out using HA- 153 Sm with particle size ranging between 5 and μm, and radiochemical purity above 99%. Animal models used were wistar rats and new zealand rabbits. Rabbits were injected with 7,4 MBq of HA- 153 Sm while rats received between 1,85 and 92,6 MBq of HA- 153 Sm. In both cases injection was given in the intra articular area. After injection, scanning images were obtained in rabbits on the 1 st , 3 rd and 7 st day and in rats on the 2 nd and 7 th day. Biological distribution studies are conducted in the 2 hours to 9 days range in rats and one the 7 th day in rabbits. No extra articular localization of HA- 153 Sm was found in scanning conducted on rabbits by the 1 st , 3 rd and 7 st day after injection, neither on rats by the 2 nd and 7 th day. Biological distributions for rabbits and rats show localization above 99% in the intra articular area, during the evaluated periods of time. The evaluations of the biological distribution and the scintigraphic images show that fixation of HA- 153 Sm in the synovial capsule up to the 9 th day is very high

  6. CDCC calculations of fusion of 6Li with targets 144Sm and 154Sm: effect of resonance states

    Science.gov (United States)

    Gómez Camacho, A.; Lubian, J.; Zhang, H. Q.; Zhou, Shan-Gui

    2017-12-01

    Continuum Discretized Coupled-Channel (CDCC) model calculations of total, complete and incomplete fusion cross sections for reactions of the weakly bound 6Li with 144,154Sm targets at energies around the Coulomb barrier are presented. In the cluster structure frame of 6Li→α+d, short-range absorption potentials are considered for the interactions between the ground state of the projectile 6Li and α-d fragments with the target. In order to separately calculate complete and incomplete fusion and to reduce double-counting, the corresponding absorption potentials are chosen to be of different range. Couplings to low-lying excited states 2+, 3- of 144Sm and 2+, 4+ of 154Sm are included. So, the effect on total fusion from the excited states of the target is investigated. Similarly, the effect on fusion due to couplings to resonance breakup states of 6Li, namely, l=2, J π =3+,2+,1+ is also calculated. The latter effect is determined by using two approaches, (a) by considering only resonance state couplings and (b) by omitting these states from the full discretized energy space. Among other things, it is found that both resonance and non-resonance continuum breakup couplings produce fusion suppression at all the energies considered. A. Gómez Camacho from CONACYT, México, J. Lubian from CNPq, FAPERJ, Pronex, Brazil. S.G.Z was partly supported by the NSF of China (11120101005, 11275248, 11525524, 11621131001, 11647601, 11711540016), 973 Program of China (2013CB834400) and the Key Research Program of Frontier Sciences of CAS. H.Q.Z. from NSF China (11375266)

  7. Epitelización inducida por células troncales derivadas del tejido adiposo

    OpenAIRE

    M. Meruane; S. Benítez; M. Rojas; A. Sagredo; K. Marcelain; B. Villalobos

    2014-01-01

    El tratamiento de lesiones con pérdida de tejido cutáneo ha mejorado notablemente con el advenimiento de la bioingeniería tisular. Una alternativa en desarrollo es la utilización de sustitutos dérmicos combinados con células troncales derivadas del tejido adiposo autólogo. Estudios previos nos muestran que con esta técnica es posible optimizar la angiogénesis y la síntesis de colágeno, sin embargo potenciar la epitelización es un tema pendiente por resolver. En el presente estudio evaluamos l...

  8. Estudios sobre la función de las células dendríticas y su aplicación en inmunoterapia del cáncer

    OpenAIRE

    Suarez, N. (Natalia); Gonzalez, A. (Álvaro); Melero, I. (Ignacio)

    2013-01-01

    Se ha realizado un ensayo clínico en fase II con vacunas de células dendríticas (CD)comprobando que el tratamiento combinado basado en la vacunación con CD (obtenidas a partir de la diferenciación de monocitos de sangre periférica y pulsadas con lisado tumoral autólogo) y la administración de ciclofosfamida, reduce la población de linfocitos T reguladores, las células endoteliales y las células tumorales en sangre periférica en algunos pacientes con cáncer avanzado. Las CD-tipo 1 obtenidas pr...

  9. Plasmon-enhanced luminescence of Sm complex using silver nanoparticles in Polyvinyl Alcohol

    Energy Technology Data Exchange (ETDEWEB)

    Kaur, Gagandeep; Verma, R.K.; Rai, D.K. [Laser and Spectroscopy Laboratory, Department of Physics, Banaras Hindu University, India 221005 (India); Rai, S.B., E-mail: sbrai49@yahoo.co.in [Laser and Spectroscopy Laboratory, Department of Physics, Banaras Hindu University, India 221005 (India)

    2012-07-15

    Silver (Ag) nanoparticles (NPs) were prepared by laser ablation in water with an aim to enhance the luminescence of rare earth coordinated complex in polymer host. A fixed concentration of the complex containing Samarium (Sm), Salicylic acid (Sal) and 1, 10-phenanthroline (Phen) were combined with different concentrations of silver NPs in PolyVinyl Alcohol at room temperature. Absorption spectrum and XRD patterns of the sample show that the Sm(Sal){sub 3}Phen complex is accompanied by Ag NPs. The luminescence from the complex was recorded in the presence and absence of Ag NPs using two different excitation wavelengths viz. 400 and 355 nm. Of these, 400 nm radiation falls in the surface plasmon resonance of Ag NPs. It was found that the Ag NPs led to a significant enhancement in luminescence of the complex. Surprisingly, a high concentration of Ag NPs tends to quench the luminescence. - Highlights: Black-Right-Pointing-Pointer Sm complex with Ag nanoparticles in PVA was prepared at room temperature. Black-Right-Pointing-Pointer UV-vis absorption and XRD confirms the presence of Sm complex and Ag NPs. Black-Right-Pointing-Pointer Enhancement in luminescence of complex was observed with Ag NPs. Black-Right-Pointing-Pointer Coupling between radiative transitions of Sm and SPR of NPs enhances the emission. Black-Right-Pointing-Pointer The higher concentration of Ag NPs quenches the luminescence of the complex.

  10. Sm isotope composition and Sm/Eu ratio determination in an irradiated 153Eu sample by ion exchange chromatography-quadrupole inductively coupled plasma mass spectrometry combined with double spike isotope dilution technique

    International Nuclear Information System (INIS)

    Bourgeois, M.; Isnard, H.; Gourgiotis, A.; Stadelmann, G.; Gautier, C.; Mialle, S.; Nonell, A.; Chartier, F.

    2011-01-01

    Within the framework of the research undertaken by the French Atomic Energy Commission on transmutation of long-lived radionuclides, targets of highly enriched actinides and fission products were irradiated in the fast neutron reactor Phenix. Precise and accurate measurements of the isotopic and elemental composition of the enriched elements are therefore required. In order to obtain the uncertainties of several per mil and to reduce handling time and exposure to analyst on radioactive material, the on-line coupling of ion exchange chromatography with quadrupole inductively coupled plasma mass spectrometry has been associated with the technique of the double spike isotope dilution. We present in this paper the results obtained on an irradiated sample of Europium oxide powder (enriched at 99.13% in 153 Eu). After irradiation of around 5 mg of Eu 2 O 3 powder the theoretical calculations predict the formation of several micrograms of gadolinium and samarium isotopes. In relation to the very high activity of the sample after irradiation and the very low quantity of Sm formed, the on-line ion exchange chromatography separation of Gd, Sm and Eu before Sm isotope ratio measurements has been developed for the quantification of the 152 Sm/ 153 Eu ratio. These on-line measurements were associated with the double spike isotope dilution technique after calibration of a 147 Sm/ 151 Eu spike solution. The external reproducibility of Sm isotopic ratios was determined to be around 0.5% (2 σ) resulting in a final uncertainty on the 152 Sm/ 153 Eu ratio of around 1% (2 σ). These on-line measurements present therefore a robust and high-throughput alternative to the thermal-ionisation mass spectrometry technique used so far in combination with off-line chromatographic separation, particularly in nuclear applications where characterisation of high activity sample solutions is required. (authors)

  11. Octupole excitations in 146Sm

    International Nuclear Information System (INIS)

    Bizzeti, P.G.; Bizzetti-Sona, A.M.

    1998-01-01

    The mean lives of the lowest 9 - and 12 + states of 146 Sm have been measured by means of the RDM. Their (preliminary) values are r m (9 - )=0.97±0.05 ns and r m (12 + )=15±2 ps, respectively. The strengths of the collective E3 transitions of the 12 + →9 - →6 6 cascade are compared with the corresponding ones in 148 Gd

  12. Catalytic properties of oxygen adsorbed on NiO-Sm/sub 2/O/sub 3/ binary oxides

    Energy Technology Data Exchange (ETDEWEB)

    Tadasu, Y.; Niwa, H.; Matsuda, Y.

    1978-02-01

    Various rare earths were screened as promoters for a nickel oxidation catalyst, and samarium (Sm) was selected for further studies. The activity of a physical mixture of NiO/Sm/sub 2/O/sub 3/ and SiC for the oxidation of 500 ppm nitric oxide with 5% oxygen in nitrogen to nitrogen dioxide at 320/sup 0/C went through a maximum with increasing Sm/sub 2/O/sub 3/ content of the catalyst. The most active catalyst, which contained 3.75% Sm/sub 2/O/sub 3/, was 3.7 times as active as pure nickel oxide. Temperature-programed desorption of oxygen from the catalysts revealed three peaks, ..cap alpha.. at 220/sup 0/-230/sup 0/C ..beta.. at 370/sup 0/-380/sup 0/C, and ..gamma.. at 530/sup 0/-540/sup 0/C, for all catalysts except pure Sm/sub 2/O/sub 3/. The amount of adsorbed oxygen increased with increasing Sm/sub 2/O/sub 3/ content to 3.75%, and then decreased with further Sm/sub 2/O/sub 3/ increases. The catalytic activity was correlated to oxygen in the ..beta..-state. Graphs, spectra, and table.

  13. Maintenance of T1 response as induced during PEG-IFNalpha plus ribavirin therapy controls viral replication in genotype-1 patients with chronic hepatitis C La respuesta inmune T1 inducida durante el tratamiento con PEG-IFNα mαs ribavirina controla la replicaciσn viral en pacientes con hepatitis crónica C

    Directory of Open Access Journals (Sweden)

    M. Trapero

    2005-07-01

    Full Text Available Objectives: to analyze the T1/T2 cytokine profile in CD8 T cells from peripheral blood mononuclear cells from patients with genotype-1 CHC during treatment with pegylated interferon (Peg-IFN α2a plus ribavirin (RBV. To correlate Th1/Th2 balance with virological response. Patients and methods: in this prospective longitudinal study, a total of 28 naïve genotype-1 CHC patients received Peg-IFNα2a (180 µg/week plus RBV (1-1.2 g/day for 48 weeks. All patients (mean age 45 ± 8 years completed treatment and follow-up: 12 (43% achieved a sustained virological response (SVR, 13 relapsed after end of treatment (47%, and only 3 (10% were non-responders. Sixteen healthy controls were also analyzed (mean age 39 ± 17 years. The production of IL-4, IIFNγ, and TTNFα by CD8 T cells was measured by intracytoplasmic detection using flow cytometry in both resting and stimulated cells with a phorbol ester. Statistics: Student's t test for independent values, χ2 test, and ANOVA test were used; relapsers and non-responders were joined to achieve a higher statistical power. Results: at third month during treatment, phorbol ester-stimulated-IL-4 levels tend to be lower in patients who presented with SVR versus those who did not (0.97 vs 2.58; p = 0.1. No statistically significant differences were found in IIFNγ and TTNFα levels at month 3. At EOT, the stimulated-IIFNγ production was significantly higher in patients with SVR (20 vs. 8; p Objetivos: analizar el perfil de citocinas T1/T2 producidas por los linfocitos T CD8+ de sangre periférica en pacientes con hepatitis crónica C (HCC y genotipo 1 durante el tratamiento con interferón pegilado (Peg-IFN α2a y ribavirina (RBV y compararlos con controles sanos. Correlacionar el balance T1/T2 con la respuesta virológica al tratamiento combinado. Pacientes y métodos: en este estudio prospectivo longitudinal se incluyeron 28 pacientes naïve con HCC genotipo 1 tratados con Peg-IFNα2a (180 µg/semana más RBV

  14. Proyecto Energético Palmdale; Decisión del Permiso Final

    Science.gov (United States)

    Proyecto Energético Palmdale: EPA Región 9 por el presente emite aviso de su decisión final, el cumplimiento con la Ley Federal de Aire Limpio, para la construcción de una planta generadora de electricidad de ciclo combinado y alimentada por gas natural

  15. Preparation and structure characterization of SmCo5(0001) epitaxial thin films grown on Cu(111) underlayers

    International Nuclear Information System (INIS)

    Ohtake, Mitsuru; Nukaga, Yuri; Futamoto, Masaaki; Kirino, Fumiyoshi

    2009-01-01

    SmCo 5 (0001) epitaxial films were prepared on Cu(111) single-crystal underlayers formed on Al 2 O 3 (0001) substrates at 500 deg. C. The nucleation and growth mechanism of (0001)-oriented SmCo 5 crystal on Cu(111) underlayer is investigated and a method to control the nucleation is proposed. The SmCo 5 epitaxial thin film formed directly on Cu underlayer consists of two types of domains whose orientations are rotated around the film normal by 30 deg. each other. By introducing a thin Co seed layer on the Cu underlayer, a SmCo 5 (0001) single-crystal thin film is successfully obtained. Nucleation of SmCo 5 crystal on Cu underlayer seems controllable by varying the interaction between the Cu underlayer and the SmCo 5 layer

  16. Radioisotope production in Malaysia

    Energy Technology Data Exchange (ETDEWEB)

    Wan Awang, Wan Anuar [Medical Technology Div., Malaysian Inst. for Nuclear Technology Research (MINT) (Malaysia)

    1998-10-01

    Production of Mo-99 by neutron activation of Mo-99 in Malaysia began as early as 1984. Regular supply of the Tc-99m extracted from it to the hospitals began in early 1988 after going through formal registration with the Malaysian Ministry of Health. Initially, the weekly demand was about 1.2 Ci of Mo-99 which catered the needs of 3 nuclear medicine centres. Sensitive to the increasing demand of Tc-99m, we have producing our own Tc-99m generator from imported TeO{sub 2} because irradiation TeO{sub 2} with our reactor give low yield of I-131. We have established the production of radioisotope for industrial use. By next year, Sm-153 EDTMP will be produce after we have license from our competent authority. (author)

  17. Sierra/SM theory manual.

    Energy Technology Data Exchange (ETDEWEB)

    Crane, Nathan Karl

    2013-07-01

    Presented in this document are the theoretical aspects of capabilities contained in the Sierra/SM code. This manuscript serves as an ideal starting point for understanding the theoretical foundations of the code. For a comprehensive study of these capabilities, the reader is encouraged to explore the many references to scientific articles and textbooks contained in this manual. It is important to point out that some capabilities are still in development and may not be presented in this document. Further updates to this manuscript will be made as these capabilites come closer to production level.

  18. The QCD/SM Working Group: Summary Report

    International Nuclear Information System (INIS)

    Dobbs, M.

    2004-01-01

    Among the many physics processes at TeV hadron colliders, we look most eagerly for those that display signs of the Higgs boson or of new physics. We do so however amid an abundance of processes that proceed via Standard Model (SM) and in particular Quantum Chromodynamics (QCD) interactions, and that are interesting in their own right. Good knowledge of these processes is required to help us distinguish the new from the known. Their theoretical and experimental study teaches us at the same time more about QCD/SM dynamics, and thereby enables us to further improve such distinctions. This is important because it is becoming increasingly clear that the success of finding and exploring Higgs boson physics or other New Physics at the Tevatron and LHC will depend significantly on precise understanding of QCD/SM effects for many observables. To improve predictions and deepen the study of QCD/SM signals and backgrounds was therefore the ambition for our QCD/SM working group at this Les Houches workshop. Members of the working group made significant progress towards this on a number of fronts. A variety of tools were further developed, from methods to perform higher order perturbative calculations or various types of resummation, to improvements in the modeling of underlying events and parton showers. Furthermore, various precise studies of important specific processes were conducted. A significant part of the activities in Les Houches revolved around Monte Carlo simulation of collision events. A number of contributions in this report reflect the progress made in this area. At present a large number of Monte Carlo programs exist, each written with a different purpose and employing different techniques. Discussions in Les Houches revealed the need for an accessible primer on Monte Carlo programs, featuring a listing of various codes, each with a short description, but also providing a low-level explanation of the underlying methods. This primer has now been compiled and a

  19. Generalized conventional and intelligent supervisory control system for combined cycle generation power plants; Sistema de control supervisorio generalizado convencional e inteligente para centrales de generacion de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Martinez Morales, Miguel Angel

    2004-12-15

    (conventional or intelligent) is possible to get more power generation than if we use the automatic methods based on feedback MW control. Consequently, the financial benefit due to the MW generated along a period of 2 months, is equivalent to return the investment required if the CCPP would had been repowered. Test also showed that with the fuzzy based SGC is possible to get a 'little more' power generation than if we use the PID based SGC. The development and implementation of the SGC was made in three phases: First Phase: Upgrading of the simulation dynamic mathematical model and implementation in a new software platform based on LabWindows/CVI. Second Phase: Design, implementation and testing of the PID based SGC. Third Phase: Design and implementation and testing of the Intelligent SGC, based in fuzzy logic. [Spanish] El programa de obras de generacion de la Comision Federal de Electricidad (CFE) del ano 2004 al ano 2008 esta caracterizado por el dominio del proceso de ciclo combinado para la expansion de generacion de energia en Mexico [CFE, 2000]. De acuerdo con los datos presentados por esta fuente, el incremento estimado en la capacidad de generacion de potencia electrica es de 12876 MW, de los cuales las centrales de ciclo combinado aportaran 10655 MW, lo que representa el 82.75%. Bajo estas expectativas de expansion de generacion de energia en Mexico, en este trabajo de tesis se desarrollo un sistema de control supervisorio generalizado (CSG) convencional (PID) e inteligente (logica difusa) para una central de generacion de ciclo combinado, el cual permite lograr la operacion optima de la planta a traves del arranque automatico de las unidades generadoras y obtener la maxima cantidad posible de potencia electrica en forma automatica y segura. Para el desarrollo del CSG se implanto un lazo de control por temperatura para el sistema de turbina de gas (TG) y un lazo de control por presion estrangulada para la turbina de vapor (TV). El diseno de estos sistemas

  20. Correlation between the nanocrystalline Sm(Fe,Mo){sub 12} and its out of equilibrium phase Sm(Fe,Mo){sub 10}

    Energy Technology Data Exchange (ETDEWEB)

    Khazzan, S. [CMTR, ICMPE, UMR7182, CNRS - Université Paris Est, 2-8 rue Henri Dunant, F-94320 Thiais (France); Laboratoire Matériaux Organisation et Propriétés, Faculté des Sciences de Tunis, Université de Tunis El Manar, 2092 Tunis (Tunisia); Bessais, L., E-mail: bessais@glvt.cnrs.fr [CMTR, ICMPE, UMR7182, CNRS - Université Paris Est, 2-8 rue Henri Dunant, F-94320 Thiais (France); Van Tendeloo, G. [EMAT, University of Antwerp, B-2020 Antwerp (Belgium); Mliki, N. [Laboratoire Matériaux Organisation et Propriétés, Faculté des Sciences de Tunis, Université de Tunis El Manar, 2092 Tunis (Tunisia)

    2014-08-01

    Nanostructured Sm–Fe–Mo semi-hard magnetic material exhibiting enhanced magnetic properties can be produced by ball milling followed by recrystallization. Milled samples were annealed for 30 min in a vacuum at different temperatures (T{sub A}) between 700 and 1190 °C. The effects of heat treatment and Mo content on structural and magnetic property changes have been investigated by means of X-ray diffraction using the Rietveld method, transmission electron microscopy and magnetic measurements. For samples annealed at T{sub A}>900°C the tetragonal ThMn{sub 12}-type structure is identified, while for 700Sm(Fe{sub 1−x}Mo{sub x}){sub 10}, correlated with structural transformation towards its equilibrium derivative I4/mmm Sm(Fe{sub 1−x}Mo{sub x}){sub 12}. A maximum of the coercive field H{sub C} (H{sub C}>5kOe) has been observed for the new hexagonal P6/mmm phase suggesting that nanocrystalline Sm(Fe,Mo){sub 10}, is a semi-hard material, and is potential candidate for magnetic recording. - Highlights: • A study of the structure and magnetic properties of SmFeMo compound. • A new out of equilibrium P6/mmm-type structure was found. • Correlation between the 1/12 phase and its out of equilibrium 1/10 phase.

  1. RETOS DEL APRENDIZAJE BASADO EN PROBLEMAS

    OpenAIRE

    Carlos Antonio Poot-Delgado

    2013-01-01

    Se realiza una breve descripción de la viabilidad y retos de llevar a la práctica docente el aprendizaje basado en problemas, con una estructura organizada, donde se plasman ideas bien fundamentadas con claridad y precisión. Asimismo, se plantean reflexiones pertinentes, mediante ejercicios alusivos y ubicados en la práctica docente. Es decir, una forma de trabajo que puede ser usada por el edu- cador en una parte de su curso, combinado con otras técnicas didácticas y de- limitando los objeti...

  2. Migración y remesas: ¿están afectando la sustentabilidad de la agricultura y la soberanía alimentaria en Chiapas?

    Directory of Open Access Journals (Sweden)

    Helda Morales

    2015-01-01

    Full Text Available Con este artículo se pretende contribuir al debate sobre el impacto de la migración internacional y de las remesas en la agricultura. Presentamos los resultados de una encuesta realizada en 2011 sobre agricultura, combinados con muestreos de agrobiodiversidad en parcelas de familias con y sin migrantes de cuatro comunidades campesinas de Chiapas. En contra de lo esperado, los resultados sugieren que la migración no está provocando ni abandono de la agricultura, ni cambios sustanciales en el tipo de cultivos de las zonas estudiadas.

  3. Level Lifetime Measurements in ^150Sm

    Science.gov (United States)

    Barton, C. J.; Krücken, R.; Beausang, C. W.; Caprio, M. A.; Casten, R. F.; Cooper, J. R.; Hecht, A. A.; Newman, H.; Novak, J. R.; Pietralla, N.; Wolf, A.; Zyromski, K. E.; Zamfir, N. V.; Börner, H. G.

    2000-10-01

    Shape/phase coexistence and the evolution of structure in the region around ^152Sm have recently been of great interest. Experiments performed at WNSL, Yale University, measured the lifetime of low spin states in a target of ^150Sm with the recoil distance method (RDM) and the Doppler-shift attenuation method (DSAM). The low spin states, both yrast and non-yrast, were populated via Coulomb excitation with a beam of ^16O. The experiments were performed with the NYPD plunger in conjunction with the SPEEDY γ-ray array. The SCARY array of solar cells was used to detect backward scattered projectiles, selecting forward flying Coulomb excited target nuclei. The measured lifetimes yield, for example, B(E2) values for transitions such as the 2^+2 arrow 2^+1 and the 2^+3 arrow 0^+_1. Data from the RDM measurment and the DSAM experiment will be presented. This work was supported by the US DOE under grants DE-FG02-91ER-40609 and DE-FG02-88ER-40417.

  4. Schistosome tegumental ecto-apyrase (SmATPDase1 degrades exogenous pro-inflammatory and pro-thrombotic nucleotides

    Directory of Open Access Journals (Sweden)

    Akram A. Da’dara

    2014-03-01

    Full Text Available Schistosomes are parasitic worms that can survive in the hostile environment of the human bloodstream where they appear refractory to both immune elimination and thrombus formation. We hypothesize that parasite migration in the bloodstream can stress the vascular endothelium causing this tissue to release chemicals alerting responsive host cells to the stress. Such chemicals are called damage associated molecular patterns (DAMPs and among the most potent is the proinflammatory mediator, adenosine triphosphate (ATP. Furthermore, the ATP derivative ADP is a pro-thrombotic molecule that acts as a strong activator of platelets. Schistosomes are reported to possess at their host interactive tegumental surface a series of enzymes that could, like their homologs in mammals, degrade extracellular ATP and ADP. These are alkaline phosphatase (SmAP, phosphodiesterase (SmNPP-5 and ATP diphosphohydrolase (SmATPDase1. In this work we employ RNAi to knock down expression of the genes encoding these enzymes in the intravascular life stages of the parasite. We then compare the abilities of these parasites to degrade exogenously added ATP and ADP. We find that only SmATPDase1-suppressed parasites are significantly impaired in their ability to degrade these nucleotides. Suppression of SmAP or SmNPP-5 does not appreciably affect the worms’ ability to catabolize ATP or ADP. These findings are confirmed by the functional characterization of the enzymatically active, full-length recombinant SmATPDase1 expressed in CHO-S cells. The enzyme is a true apyrase; SmATPDase1 degrades ATP and ADP in a cation dependent manner. Optimal activity is seen at alkaline pH. The Km of SmATPDase1 for ATP is 0.4 ± 0.02 mM and for ADP, 0.252 ± 0.02 mM. The results confirm the role of tegumental SmATPDase1 in the degradation of the exogenous pro-inflammatory and pro-thrombotic nucleotides ATP and ADP by live intravascular stages of the parasite. By degrading host inflammatory signals

  5. Conventional and intelligent generalized supervisory control for combined cycle generating power stations.; Control supervisiorio generalizado convencional e inteligente para centrales de generacion de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Martinez M, Miguel A; Sanchez P, Marino [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Gonzalez Rubio S, Jose L [Cento Nacional de Investigacion y Desarrollo Tecnologico (Cenidet), Cuernavaca, Morelos (Mexico)

    2005-07-01

    Under the expectations of expansion of electric power generation in Mexico, this work exposes the development of a conventional and intelligent generalized supervisory control (CSG) for a combined cycle generation power plant. This one allows to obtain the optimal operation of the power plant through the automatic starting of the generating units and to obtain the maximum possible amount of electrical power in automatic and safe form. For the development of the CSG a control loop by temperature was implemented for the gas turbine system and a control loop by strangled pressure for the gas turbine and a control loop by strangled pressure for the steam turbine. The design of these supervisory systems was made with base in the critical limits on the involved variables of the process: blading average temperature, for the gas turbine (GT) and strangled pressure for the steam turbine (ST) [Spanish] Bajo estas expectativas de expansion de generacion de energia en Mexico, este trabajo expone el desarrollo de un control supervisorio generalizado (CSG) para una central generacion de ciclo combinado. Este permite lograr la operacion optima de la planta a traves del arranque automatico de las unidades generadoras y obtener la maxima cantidad posible de potencia electrica en forma automatica y segura. Para el desarrollo del CSG se implanto un lazo de control por temperatura para el sistema de turbina de gas y un lazo de control por presion estrangulada para la turbina de gas y un lazo de control por presion estrangulada para la turbina de vapor. El diseno de estos sistemas supervisorio se realizo con base en los limites criticos de las variables del proceso involucradas: temperatura promedio de empaletado para la turbina de gas (TG) y presion estrangulada para la turbina de vapor (TV)

  6. Microstructural changes during the slow-cooling annealing of nanocrystalline SmCo 2:17 type magnets

    International Nuclear Information System (INIS)

    Romero, S.A.; Campos, M.F. de; Castro, J.A. de; Moreira, A.J.; Landgraf, F.J.G.

    2013-01-01

    Highlights: ► Use of the Stoner-Wohlfarth Callen Liu Cullen model in 2:17 type magnets. ► Data suggest exchange coupling between Sm2(CoFe)17 and Sm(CoCu)5 phases. ► It is given structural data for phase Sm0.33Zr0.67TM3, with TM=Co,Fe,Cu. ► The beneficial effect of the slow cooling treatment is explained. - Abstract: The microstructure and magnetic properties of 2:17 type isotropic magnets were investigated. The slow cooling heat treatment (cooling at 1 °C/min from 820 to 400 °C, and isothermal treatment during 24 h) was interrupted after the temperatures of 820, 700, 600 and 500 °C and their hysteresis were measured with fields up to 9 T. The fully heat treated sample presented coercivity (μ 0 H) of 3.32 T, after 24 h at 400 °C. The microstructure was investigated with SEM–FEG (Scanning Electron Microscope with Field Emission Gun) and X-ray Diffraction Rietveld analysis. The application of the Stoner–Wohlfarth–Callen–Liu–Cullen (SW–CLC) model points out exchange coupling between ferromagnetic Sm 2 (CoFe) 17 nanocells and ferromagnetic Sm(CoCu) 5 present at the cell boundary phase. The results are interpreted with the double shell model: first-a cobalt-rich ferromagnetic Sm(CoCu) 5 shell originates exchange coupling and second-a copper-rich paramagnetic Sm(CuCo) 5 shell produces magnetic decoupling. This double shell helps to maximize coercivity and remanence. The anisotropy field of the Sm 2 (CoFe) 17 cell phase was estimated in 7 T with the SW–CLC model.

  7. Recycled Sm-Co bonded magnet filaments for 3D printing of magnets

    Science.gov (United States)

    Khazdozian, Helena A.; Manzano, J. Sebastián; Gandha, Kinjal; Slowing, Igor I.; Nlebedim, Ikenna C.

    2018-05-01

    Recycling of rare earth elements, such as Sm and Nd, is one technique towards mitigating long-term supply and cost concerns for materials and devices that depend on these elements. In this work recycled Sm-Co powder recovered from industrial grinding swarfs, or waste material from magnet processing, was investigated for use in preparation of filament for 3D printing of bonded magnets. Recycled Sm-Co powder recovered from swarfs was blended into polylactic acid (PLA). Up to 20 vol.% of the recycled Sm-Co in PLA was extruded at 160°C to produce a filament. It was demonstrated that no degradation of magnetic properties occurred due to the preparation or extrusion of the bonded magnet material. Good uniformity of the magnetic properties is exhibited throughout the filament, with the material first extruded being the exception. The material does exhibit some magnetic anisotropy, allowing for the possibility of the development of anisotropic filaments. This work provides a path forward for producing recycled magnetic filament for 3D printing of permanent magnets.

  8. Magneto-optical imaging of iron-oxypnictide SmFeAsO1-xFx and SmFeAsO1-y

    International Nuclear Information System (INIS)

    Tamegai, T.; Nakajima, Y.; Tsuchiya, Y.; Iyo, A.; Miyazawa, K.; Shirage, P.M.; Kito, H.; Eisaki, H.

    2009-01-01

    We have prepared iron-oxypnictide SmFeAsO 1-x F x by ambient-pressure technique and SmFeAsO 1-y by high-pressure technique, and characterized their bulk and local magnetic properties by using SQUID magnetometer and magneto-optical imaging. While the high-pressure samples have densities close to the theoretical value, the ambient-pressure samples have several small voids. Despite these structural differences between the two kinds of samples, they both have superconducting transition temperature above 50 K. In addition, magneto-optical images for both samples show similar kinds of inhomogeneities with large current concentrated in several grains and with small intergranular current. The estimated intragranular currents for both samples are over 10 5 A/cm 2 at low temperatures and low fields.

  9. Efeitos de um tratamento combinado (vitamina C pré-exercício e alongamento FNP, tratamento com ultrassom pós-exercício sobre marcadores de dano muscular induzido por exercício

    Directory of Open Access Journals (Sweden)

    Ali Jalalvand

    2012-10-01

    Full Text Available CONTEXTO: Várias estratégias de recuperação têm sido utilizadas na tentativa de minimizar os sintomas da dor muscular de início tardio (DMIT. Contudo, evidências científicas que apoiem este efeito profilático (pré-exercício e terapêutico (pós-exercício de um tratamento combinado (FNP e vitamina C, ultrassom no dano muscular são inexistentes. OBJETIVO: Investigar os efeitos de um tratamento combinado (FNP e vitamina C, ultrassom nos marcadores bioquímicos (níveis enzimáticos e funcionais (ângulo do cotovelo, circunferência de braço, taxa de dor de dano muscular induzido por exercício. MÉTODO: Amostra randomizada controlada. LOCAL: Laboratório da Universidade. PARTICIPANTES: Alunos universitários masculinos participaram voluntariamente do estudo, o qual não reportou nenhuma dor muscular de início tardio por no mínimo seis meses antes do estudo. Posteriormente, os sujeitos foram agrupados aleatoriamente em subgrupos com mão controle e mão experimental. INTERVENÇÃO(ÕES: Programa de exercício para indução de dano muscular induzido por exercício envolvendo o teste de bíceps Scott (contração excêntrica com duas mãos. PROCEDIMENTO(S PRINCIPAL(IS: Circunferência de braço relaxado, circunferência de braço flexionado, ângulo de cotovelo em descanso, circunferência de antebraço, amplitude de movimento de cotovelo flexionado, amplitude de movimento de cotovelo estendido, dano muscular induzido por exercício, força máxima voluntária isométrica e isocinética foram registrados basal, imediatamente após exercício e 24, 48, 72 e 96 horas após exercício. RESULTADOS: O subgrupo experimental manifestou redução de sintomas de DMIT em menor amplitude de movimento de cotovelo flexionado e amplitude de movimento de cotovelo estendido, menor perda de força isométrica e isocinética voluntária máxima (P 0,05. CONCLUSÃO: Este tratamento combinado foi eficiente em contração máxima voluntária isom

  10. The dynamics of the laser-induced metal-semiconductor phase transition of samarium sulfide (SmS)

    International Nuclear Information System (INIS)

    Kaempfer, Tino

    2009-01-01

    The present thesis is dedicated to the experimental study of the metal-semiconductor phase transition of samarium sulfide (SmS): Temperature- and time-resolved experiments on the characterization of the phase transition of mixed-valence SmS samples (M-SmS) are presented. The measurement of the dynamics of the laser-induced phase transition pursues via time-resolved ultrashort-time microscopy and by X-ray diffraction with sub-picosecond time resolution. The electronic and structural processes, which follow an excitation of M-SmS with infrared femtosecond laser pulses, are physically interpreted on the base of the results obtained in this thesis and model imaginations. [de

  11. Effect of the addition of Sm2O3 on the microstructure of laser cladding alloy coating layers

    Science.gov (United States)

    Zhang, Shi Hong; Li, Ming Xi; Cho, Tong Yul; Yoon, Jae Hong; Fang, Wei; Joo, Yun Kon; Kang, Jin Ho; Lee, Chan Gyu

    2008-06-01

    The effects on the microstructures and phases of coating layers by the addition of micron-sized (m) and nano-sized (n) (m&n) Sm2O3 powders were investigated. The coating materials, which were prepared by means of 2.0 kW CO2 laser cladding, consist of a powder mixture of m Ni-based alloy (NBA) powders comprising 1.5 wt.% m Sm2O3 and 3.0% n Sm2O3 powders. The results indicate that γ-Ni, Cr23C6 and Ni3B are the primary phases of the NBA coatings. The Fe7Sm and Ni3Si phases are highlighted by the addition of m&n Sm2O3 powders. From the substrate, planar crystal layers are first grown in all NBA and m&n Sm2O3/NBA coatings. The dendrite growth then occurs as a result of the addition of the m Sm2O3 powder, and the equiaxed dendrite growth occurs as a result of the addition of the n Sm2O3. With the addition of a rare earth oxide such as Sm2O3 powder, the width of the planar crystal becomes smaller than that of the NBA coating.

  12. Optic and electro-optic investigations on SmQ, SmCA* and L phases in highly chiral compounds

    International Nuclear Information System (INIS)

    Manai, M.; Gharbi, A.; Marcerou, J.P.; Nguyen, H.T.; Rouillon, J.C.

    2005-01-01

    Chiral molecules give rise to a large variety of mesophases. Well-known examples are cholesteric or ferroelectric smectic phases where the chirality tends to favor a macroscopic twist. Furthermore, the molecular core length (l) plays an important role on the range of the mesophases and on the temperature (T NI ) for the onset of orientational order. The tendency for T NI is to increase (going over 200 - bar C for some compounds) with increasing l. We report in this paper on a selection of compounds which have been designed in order to favor an anticlinic smectic ordering together with high chirality. As a common feature, they have a long rigid core with four benzene rings and a chiral chain (usually the same) at each end. They display a locally anisotropic liquid phase referred to as ''L phase'' in a large temperature range between T NI and the low temperature SmQ or SmC A * phase. Optical rotatory power (ORP), birefringence and electro-optic studies have been performed with these compounds

  13. Anmeldelse af: Bruner og de små børns læring

    DEFF Research Database (Denmark)

    Christensen, Bodil

    2013-01-01

    Anmeldelse af: Bruner og de små børns læring - en introduktion af Sandra Smidt, Hans Reitzels Forlag, 2013.......Anmeldelse af: Bruner og de små børns læring - en introduktion af Sandra Smidt, Hans Reitzels Forlag, 2013....

  14. Síndrome metabólico. Asociación entre GLP-1 y factores de riesgo cardiovascular

    OpenAIRE

    Pérez-Durillo, Francsco Tomás

    2017-01-01

    [ES] Objetivos: Determinar la variación de niveles plasmáticos de péptido similar al glucagón (GLP-1) y de actividad dipeptidil peptidasa 4 (DPP4) en pacientes con síndrome metabólico (SM). Diseño: Estudio descriptivo transversal. 46 sujetos (entre 50-65 años) distribuidos en grupo SM y grupo sin SM. Resultados: Los niveles postprandiales de GLP-1 fueron superiores en hombres con SM respecto a las mujeres y en mujeres sin SM respecto a los hombres. Los pacientes diagnosticados de SM de ...

  15. Analysis of the magnetic anisotropy in SmCo5 and GdCo5

    International Nuclear Information System (INIS)

    Zhao, T.; Jin, H.; Groessinger, R.; Kou, X.; Kirchmayr, H.R.

    1991-01-01

    The temperature dependence of the magnetic anisotropy constant K 1 for SmCo 5 and GdCo 5 is well reproduced by calculations based on a single-ion model taking into account the anisotropies of the R--Co exchange interaction and the Co-sublattice magnetic moment. The anisotropy of the R--Co exchange interaction plays an important role in reproducing the experimental K 1 (T) for SmCo 5 and GdCo 5 . It is found that the absolute value of the second order crystalline electric field parameter A 0 2 in SmCo 5 decreases monotonically with increasing temperature

  16. Fabrication and properties of SmFe2-PZT magnetoelectric thin films

    KAUST Repository

    Giouroudi, Ioanna

    2013-05-17

    Magnetoelectric (ME) thin film composites are attracting a continually increasing interest due to their unique features and potential applications in multifunctional microdevices and integrated units such as sensors, actuators and energy harvesting modules. By combining piezoelectric and highly magnetostrictive thin films, the potentialities of these materials increase. In this paper we report the fabrication of SmFe2 and PZT thin films and the investigation of their properties. First of all, a ~ 400 nm thin SmFe film was deposited on top of Si/SiO2 substrate by magnetron sputter deposition. Afterwards, a 140 nm Pt bottom electrode was sputtered on top of the SmFe film forming a bottom electrode. Spin coating was employed for the deposition of the 150 nm thin PZT layer. A PZT solution with 10 %Pb excess was utilized for this fabrication step. Finally, circular Pt top electrodes were sputtered as top electrodes. This paper focuses on the microstructure of the individual films characterized by X-Ray diffractometer (XRD) and scanning electron microscopy (SEM). A piezoelectric evaluation system, aixPES, with TF2000E analyzer component was used for the electric hysteresis measurements of PZT thin films and a vibrating sample magnetometer (VSM) was employed for the magnetic characterization of the SmFe. The developed thin films and the fabricated double layer SmFe-PZT exhibit both good ferromagnetic and piezoelectric responses which predict a promising ME composite structure. The quantitative chemical composition of the samples was confirmed by energy dispersive spectroscopy (EDX). © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

  17. Fabrication and properties of SmFe2-PZT magnetoelectric thin films

    KAUST Repository

    Giouroudi, Ioanna; Alnassar, Mohammed; Kosel, Jü rgen

    2013-01-01

    Magnetoelectric (ME) thin film composites are attracting a continually increasing interest due to their unique features and potential applications in multifunctional microdevices and integrated units such as sensors, actuators and energy harvesting modules. By combining piezoelectric and highly magnetostrictive thin films, the potentialities of these materials increase. In this paper we report the fabrication of SmFe2 and PZT thin films and the investigation of their properties. First of all, a ~ 400 nm thin SmFe film was deposited on top of Si/SiO2 substrate by magnetron sputter deposition. Afterwards, a 140 nm Pt bottom electrode was sputtered on top of the SmFe film forming a bottom electrode. Spin coating was employed for the deposition of the 150 nm thin PZT layer. A PZT solution with 10 %Pb excess was utilized for this fabrication step. Finally, circular Pt top electrodes were sputtered as top electrodes. This paper focuses on the microstructure of the individual films characterized by X-Ray diffractometer (XRD) and scanning electron microscopy (SEM). A piezoelectric evaluation system, aixPES, with TF2000E analyzer component was used for the electric hysteresis measurements of PZT thin films and a vibrating sample magnetometer (VSM) was employed for the magnetic characterization of the SmFe. The developed thin films and the fabricated double layer SmFe-PZT exhibit both good ferromagnetic and piezoelectric responses which predict a promising ME composite structure. The quantitative chemical composition of the samples was confirmed by energy dispersive spectroscopy (EDX). © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

  18. Effects of substrate temperature and Cu underlayer thickness on the formation of SmCo5(0001) epitaxial thin films

    International Nuclear Information System (INIS)

    Ohtake, Mitsuru; Nukaga, Yuri; Futamoto, Masaaki; Kirino, Fumiyoshi

    2010-01-01

    SmCo 5 (0001) epitaxial thin films were prepared on Cu(111) underlayers heteroepitaxially grown on Al 2 O 3 (0001) single-crystal substrates by molecular beam epitaxy. The effects of substrate temperature and Cu underlayer thickness on the crystallographic properties of SmCo 5 (0001) epitaxial films were investigated. The Cu atoms of underlayer diffuse into the SmCo 5 film and substitute the Co sites in SmCo 5 structure forming an alloy compound of Sm(Co,Cu) 5 . The ordered phase formation is enhanced with increasing the substrate temperature and with increasing the Cu underlayer thickness. The Cu atom diffusion into the SmCo 5 film is assisting the formation of Sm(Co,Cu) 5 ordered phase.

  19. Absorption Spectra of BaF2 Sm2O3, Sm, Gd, and Ho Plasmas

    Science.gov (United States)

    Martin, Michael; Bastiani-Ceccotti, Serena

    2009-11-01

    Knowledge of the opacities of high Z element plasmas is important in indirect drive ICF and the study of stellar evolution. There are few experimental measurements of this quantity, and its theoretical determination is difficult due to the number of possible bound electron configurations. This study aims to better the theoretical understanding of this parameter by looking at the 3d-4f transitions of BaF2, Sm2O3, Sm, Gd, and Ho plasmas at the LULI2000 facility. The plasmas are produced by radiative heating and are cold, 15 -- 40 eV, and relatively dense, ˜ .01gm/cm^3 A plasma is produced by a .5 ns laser pulse irradiating a gold hohlraum and then probed by an x-ray source created by a gold foil irradiated by a 10 ps laser pulse. The transmission is found with simultaneous source and absorption measurements by an x-ray spectrometer in the 8 - 20 å range We will compare the results with statistical atomic structure codes. From this experiment we will gain further insight into the spectral broadening of neighboring Z elements due to changing plasma temperature and into mixture thermodynamics. This is a first step towards an experimental study of astrophysical domains.

  20. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni.

    Directory of Open Access Journals (Sweden)

    Jan Dvorák

    2009-06-01

    Full Text Available Blood flukes of the genus Schistosoma are platyhelminth parasites that infect 200 million people worldwide. Digestion of nutrients from the host bloodstream is essential for parasite development and reproduction. A network of proteolytic enzymes (proteases facilitates hydrolysis of host hemoglobin and serum proteins.We identified a new cathepsin L termed SmCL3 using PCR strategies based on S. mansoni EST sequence data. An ortholog is present in Schistosoma japonicum. SmCL3 was heterologously expressed as an active enzyme in the yeast, Pichia pastoris. Recombinant SmCL3 has a broad pH activity range against peptidyl substrates and is inhibited by Clan CA protease inhibitors. Consistent with a function in degrading host proteins, SmCL3 hydrolyzes serum albumin and hemoglobin, is localized to the adult gastrodermis, and is expressed mainly in those life stages infecting the mammalian host. The predominant form of SmCL3 in the parasite exists as a zymogen, which is unusual for proteases. This zymogen includes an unusually long prodomain with alpha helical secondary structure motifs. The striking specificity of SmCL3 for amino acids with large aromatic side chains (Trp and Tyr at the P2 substrate position, as determined with positional scanning-synthetic combinatorial library, is consistent with a molecular model that shows a large and deep S2 pocket. A sequence similarity network (SSN view clusters SmCL3 and other cathepsins L in accordance with previous large-scale phylogenetic analyses that identify six super kingdoms.SmCL3 is a gut-associated cathepsin L that may contribute to the network of proteases involved in degrading host blood proteins as nutrients. Furthermore, this enzyme exhibits some unusual sequence and biophysical features that may result in additional functions. The visualization of network inter-relationships among cathepsins L suggests that these enzymes are suitable 'marker sequences' for inclusion in future phylogenetic analyses.

  1. Decay spectroscopy of 160Sm: The lightest four-quasiparticle K isomer

    Directory of Open Access Journals (Sweden)

    Z. Patel

    2016-02-01

    Full Text Available The decay of a new four-quasiparticle isomeric state in 160Sm has been observed using γ-ray spectroscopy at the RIBF, RIKEN. The four-quasiparticle state is assigned a 2π⊗2ν π52−[532], π52+[413], ν52−[523], ν72+[633] configuration. The half-life of this (11+ state is measured to be 1.8(4 μs. The (11+ isomer decays into a rotational band structure, based on a (6− ν52−[523]⊗ν72+[633] bandhead, consistent with the gK−gR values. This decays to a (5− two-proton quasiparticle state, which in turn decays to the ground state band. Potential energy surface and blocked-BCS calculations were performed in the deformed midshell region around 160Sm. They reveal a significant influence from β6 deformation and that 160Sm is the best candidate for the lightest four-quasiparticle K isomer to exist in this region. The relationship between reduced hindrance and isomer excitation energy for E1 transitions from multiquasiparticle states is considered with the new data from 160Sm. The E1 data are found to agree with the existing relationship for E2 transitions.

  2. Photoluminescence characteristics of reddish-orange Eu{sup 3+} or Sm{sup 3+} singly-doped and Eu{sup 3+} and Sm{sup 3+} co-doped KZnGd(PO{sub 4}){sub 2} phosphors

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Jun Ho; Bandi, Vengala Rao; Grandhe, Bhaskar Kumar; Jang, Ki Wan; Lee, Ho Sueb [Changwon National University, Changwon (Korea, Republic of); Yi, Soung Soo [Silla University, Busan (Korea, Republic of); Jeong, Jung Hyun [Pukyong National University, Busan (Korea, Republic of)

    2011-02-15

    Eu{sup 3+} or Sm{sup 3+} singly-doped and Eu{sup 3+} and Sm{sup 3+} co-doped KZnGd(PO{sub 4}){sub 2} phosphors were synthesized by using a conventional solid state reaction method at 750 .deg. C. The emission spectra of KZnGd{sub 1-x}(PO{sub 4}){sub 2}:Eu{sup 3+}{sub x} with {lambda}{sub ex} = 395 nm and KZnGd{sub 1-y}(PO{sub 4}){sub 2}:Sm{sup 3+}{sub y} with {lambda}{sub ex} = 403 nm phosphors showed intense {sup 5}D{sub 0} {yields} {sup 7}F{sub 1}, {sup 4}G{sub 5/2} {yields} {sup 6}H{sub 7/2} emission transitions at 595 nm and 599 nm, respectively. The optimum relative intensity of the KZnGd{sub 1-x-y}(PO{sub 4}){sub 2}:Eu{sup 3+}{sub x} , Sm{sup 3+}{sub y} phosphor was obtained for the doping concentrations of (x = 0.09, y = 0.01). In addition, the temperature dependent luminescence intensity of the synthesized phosphors was investigated and the thermal stability of the KZnGd(PO{sub 4}){sub 2}:Eu{sup 3+} phosphor was found to be higher than that of standard YAG:Ce{sup 3+} and KZnGd{sub 1-x-y}(PO{sub 4}){sub 2}:Eu{sup 3+}{sub x} Sm{sup 3+}{sub y} under near ultra-violet (NUV) light emitting diode excitation (LED). Therefore, we suggest that Eu{sup 3+} or Sm{sup 3+} singly-doped and Eu{sup 3+} and Sm{sup 3+} co-doped KZnGd(PO{sub 4}){sub 2} phosphors should be efficient for different red-color-emitting display device applications and NUV-LED-based white-light-emitting diodes.

  3. Modelo de implantação da estratégia através do uso combinado do método Hoshin Kanri e do gerenciamento de projetos

    OpenAIRE

    Rafael Pavão

    2013-01-01

    Esta dissertação propõe um modelo de implantação da estratégia através do método Hoshin Kanri, combinado ao gerenciamento de projetos, para organizar os processos do desdobramento das diretrizes e iniciativas, aumentando, desta forma, o sucesso na execução da estratégia empresarial. Elaborar a estratégia é um passo importante, contudo não basta ter um bom plano, é preciso executá-lo com sucesso, desenvolvendo as iniciativas certas, dentro do prazo e no custo necessário para atingir os objetiv...

  4. Mushrooms preserved by the combined effect of refrigeration and gamma irradiation; Champinones conservados por el efecto combinado de refrigeracion e irradiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Domenech, A M; Bauza de Faliti, M; Bocklet, M F

    1991-12-31

    In this work, the combined effect of refrigeration and gamma irradiation on diverse physical parameters to be measured in mushrooms was studied. Mushrooms (Agaricus Campestris), `bisporus` variety, of closed cap, were used. From the treatments tested, it was concluded that 0.5 KGy is the most suitable dosis to delay elongation, cap opening, stem length and surface moss growth. (Author). [Espanol] En este trabajo se ha estudiado el efecto combinado de la refrigeracion y la irradiacion gamma sobre los diversos parametros fisicos medibles en el champinon. Se utilizaron hongos del genero Agaricus Campestris, variedad bisporus, de sombrero cerrado. De los tratamientos ensayados, se ha demostrado tener efecto util la dosis de 0,5 KGy ya que se logro retardar crecimiento, apertura del sombrero, largo del pie y desarrollo de mohos en superficie. (Autor).

  5. Petri nets SM-cover-based on heuristic coloring algorithm

    Science.gov (United States)

    Tkacz, Jacek; Doligalski, Michał

    2015-09-01

    In the paper, coloring heuristic algorithm of interpreted Petri nets is presented. Coloring is used to determine the State Machines (SM) subnets. The present algorithm reduces the Petri net in order to reduce the computational complexity and finds one of its possible State Machines cover. The proposed algorithm uses elements of interpretation of Petri nets. The obtained result may not be the best, but it is sufficient for use in rapid prototyping of logic controllers. Found SM-cover will be also used in the development of algorithms for decomposition, and modular synthesis and implementation of parallel logic controllers. Correctness developed heuristic algorithm was verified using Gentzen formal reasoning system.

  6. Electron back scattered diffraction study of SmCo magnets

    International Nuclear Information System (INIS)

    Yonamine, T.; Fukuhara, M.; Machado, R.; Missell, F.P.

    2008-01-01

    The remanence and energy product of permanent magnets is a strong function of their crystallographic texture. Electron back scattered diffraction (EBSD) is a tool for texture analysis providing information about the atomic layers up to 50 nm below the surface of the material. This paper discusses experimental requirements for performing EBSD measurements on rare-earth permanent magnets and presents results on commercial SmCo magnet material. EBSD measurements proved to be very sensitive to misaligned grains and were sensitive to texture in good agreement with information provided by X-ray diffraction scans. Results for nanostructured Sm(CoFeCuZr) z magnets are also discussed

  7. Isomer decay spectroscopy of 164Sm and 166Gd: midshell collectivity around N=100.

    Science.gov (United States)

    Patel, Z; Söderström, P-A; Podolyák, Zs; Regan, P H; Walker, P M; Watanabe, H; Ideguchi, E; Simpson, G S; Liu, H L; Nishimura, S; Wu, Q; Xu, F R; Browne, F; Doornenbal, P; Lorusso, G; Rice, S; Sinclair, L; Sumikama, T; Wu, J; Xu, Z Y; Aoi, N; Baba, H; Bello Garrote, F L; Benzoni, G; Daido, R; Fang, Y; Fukuda, N; Gey, G; Go, S; Gottardo, A; Inabe, N; Isobe, T; Kameda, D; Kobayashi, K; Kobayashi, M; Komatsubara, T; Kojouharov, I; Kubo, T; Kurz, N; Kuti, I; Li, Z; Matsushita, M; Michimasa, S; Moon, C-B; Nishibata, H; Nishizuka, I; Odahara, A; Şahin, E; Sakurai, H; Schaffner, H; Suzuki, H; Takeda, H; Tanaka, M; Taprogge, J; Vajta, Zs; Yagi, A; Yokoyama, R

    2014-12-31

    Excited states in the N=102 isotones 166Gd and 164Sm have been observed following isomeric decay for the first time at RIBF, RIKEN. The half-lives of the isomeric states have been measured to be 950(60) and 600(140) ns for 166Gd and 164Sm, respectively. Based on the decay patterns and potential energy surface calculations, including β6 deformation, a spin and parity of 6- has been assigned to the isomeric states in both nuclei. Collective observables are discussed in light of the systematics of the region, giving insight into nuclear shape evolution. The decrease in the ground-band energies of 166Gd and 164Sm (N=102) compared to 164Gd and 162Sm (N=100), respectively, presents evidence for the predicted deformed shell closure at N=100.

  8. Isomer Decay Spectroscopy of Sm 164 and Gd 166 : Midshell Collectivity Around N =100

    Science.gov (United States)

    Patel, Z.; Söderström, P.-A.; Podolyák, Zs.; Regan, P. H.; Walker, P. M.; Watanabe, H.; Ideguchi, E.; Simpson, G. S.; Liu, H. L.; Nishimura, S.; Wu, Q.; Xu, F. R.; Browne, F.; Doornenbal, P.; Lorusso, G.; Rice, S.; Sinclair, L.; Sumikama, T.; Wu, J.; Xu, Z. Y.; Aoi, N.; Baba, H.; Bello Garrote, F. L.; Benzoni, G.; Daido, R.; Fang, Y.; Fukuda, N.; Gey, G.; Go, S.; Gottardo, A.; Inabe, N.; Isobe, T.; Kameda, D.; Kobayashi, K.; Kobayashi, M.; Komatsubara, T.; Kojouharov, I.; Kubo, T.; Kurz, N.; Kuti, I.; Li, Z.; Matsushita, M.; Michimasa, S.; Moon, C.-B.; Nishibata, H.; Nishizuka, I.; Odahara, A.; Şahin, E.; Sakurai, H.; Schaffner, H.; Suzuki, H.; Takeda, H.; Tanaka, M.; Taprogge, J.; Vajta, Zs.; Yagi, A.; Yokoyama, R.

    2014-12-01

    Excited states in the N =102 isotones Gd 166 and Sm 164 have been observed following isomeric decay for the first time at RIBF, RIKEN. The half-lives of the isomeric states have been measured to be 950(60) and 600(140) ns for Gd 166 and Sm 164 , respectively. Based on the decay patterns and potential energy surface calculations, including β6 deformation, a spin and parity of 6- has been assigned to the isomeric states in both nuclei. Collective observables are discussed in light of the systematics of the region, giving insight into nuclear shape evolution. The decrease in the ground-band energies of Gd 166 and Sm 164 (N =102 ) compared to Gd 164 and Sm 162 (N =100 ), respectively, presents evidence for the predicted deformed shell closure at N =100 .

  9. Evidentiation of Paramyosin (Sm-97 as a Modulating Antigen on Granulomatous Hypersensitivity to Schistosoma mansoni Eggs

    Directory of Open Access Journals (Sweden)

    Hirsch Cristine

    1997-01-01

    Full Text Available A Schistosoma mansoni adult worm anionic fraction (PIII has previously been shown to protect mice against challenge infection and to reduce pulmonary and hepatic granulomatous hypersensitivity. Serum from PIII-immunized rabbit was used to screen a lgt11 cDNA library from S. mansoni adult worm in order to identify antigens capable of modulating granulomatous hypersensitivity. We obtained four clones with 400 (Sm-III.11, 900 (Sm-III.16, 1100 (Sm-III.10 and 1300 (Sm-III.12 bp of length. All clone-specific antibodies were able to recognize most of the PIII components. The sequence analysis showed that these clones presented high homology with S. mansoni paramyosin (Sm-97. These findings ascribe a new function to this antigen with an important role in modulation of granulomatous hypersensitivity to S. mansoni eggs

  10. Synthesis, characterization and thermal expansion studies on ThO2-SmO1.5 solid solutions

    International Nuclear Information System (INIS)

    Panneerselvam, G.; Antony, M.P.

    2008-01-01

    Full text: A highly homogeneous Th 1-x Sm x O 2 ; 0 ≤ x ≤ 0.8 solid solutions were synthesized by co-precipitation technique and the co-precipitated samples were sintered at 1473 K. Compositions of the solid solutions were characterized by standard wet-chemical analysis. X-ray diffraction measurements were performed in the sintered pellets for structural analysis, lattice parameter calculation and determination of solid solubility of SmO 1.5 in ThO 2 matrix. Bulk and theoretical densities of solid solutions were also determined. A fluorite structure was observed for ThO 2 -SmO 1.5 solid solutions with 0-55.2 mol % SmO 1.5 . Their thermal expansion coefficients were measured using high temperature X-ray diffraction technique. The mean linear thermal expansivity, αm for ThO 2 -SmO 1.5 solid solutions containing 17.9, 41.7 and 52.0 mole percent of SmO 1.5 were determined in the temperature range 298 to 2000 K for the first time. The mean linear thermal expansion coefficients for ThO 2 -SmO 1.5 solid solutions are 10.47x10 -6 K -1 , 11.16x10 -6 K -1 and 11.45x10 -6 K -1 , respectively. The percentage linear thermal expansion in this temperature range, for ThO 2 -SmO 1.5 solid solutions containing 17.9, 41.7 and 52.0 mol % SmO 1.5 are 1.82,1.94 and 1.99 respectively. It is suggested that the solid solutions are stable up to 2000 K. It is also suggested that the effect and nature of the dopant are the important parameters influenced in the thermal expansion of the ThO 2

  11. Luminescence studies of Sm(III) and Cm(III) complexes in NaSCN/DHDECMP extraction systems

    CERN Document Server

    Chung, D Y; Kimura, T

    1999-01-01

    Laser-induced fluorescence (LIF) studies of Sm(III) and Cm(III) complexes in the NaSCN/DHDECMP solvent extraction system were carried out. Luminescence lifetimes were measured to determine the number of water molecules coordinated to Sm(III), Tb(III), Dy(III), and Cm(III) in the sodium thiocyanate solution and in the DHDECMP phase. The hydration number of Sm(III), Tb(III), Dy(III), and Cm(III) in the sodium thiocyanate solution decreased linearly with increasing sodium thiocyanate concentration. The hydration numbers of Sm(III), Dy(III), and Cm(III) in the DHDECMP phase decreased with increasing sodium thiocyanate concentration. The water molecules in the inner coordination sphere of Sm(III) and Dy(III) extracted into the DHDECMP were not completely removed at low sodium thiocyanate concentration but decreased with increasing sodium thiocyanate concentration. However, in the case of Cm(III) extracted into the DHDECMP phase from the sodium thiocyanate solution, there was no water in the inner coordination sphe...

  12. Radiological site assessment at sun rose claim utilizing ScanPlot{sup SM} technology

    Energy Technology Data Exchange (ETDEWEB)

    Downey, H., E-mail: heath.downey@amecfw.com [Amec Foster Wheeler, Portland, ME (United States)

    2015-07-01

    ScanPlot{sup SM} gamma spectroscopy land survey system was utilized for the overland survey of uranium at the Sun Rose Claim in the Northwest Territories. The Sun Rose Claim is a former uranium exploration site and previous investigations had identified uranium ore and waste rock. ScanPlot{sup SM} radiological scan surveys were performed utilizing a backpack system. ScanPlot{sup SM} platform utilized spectroscopy grade sodium iodide detectors configured for optimal spatial coverage and radiation detection. Survey locations were recorded using an on-board global positioning system (GPS). The radiological spectral data from the radiation detectors is automatically logged and linked with the GPS coordinates to an on-board computer to create isocontour figures using a color scale to represent radioactivity levels. The advantage of utilizing the ScanPlot{sup SM} system for this assessment is that the nature and extent of uranium is provided without having to collect and assay a large number of samples. (author)

  13. Cobertura radicular mediante la utilización de un injerto subepitelial de tejido conectivo combinado con un colgajo pediculado avanzado coronalmente

    Directory of Open Access Journals (Sweden)

    Antonio Díaz Caballero

    2010-01-01

    Full Text Available Las recesiones gingivales son un hallazgo clínico muy frecuente que ocasionan problemas estéticos, hipersensibilidad dentaria y dificultad para llevar a cabo una correcta higiene oral en los pacientes. Uno de los objetivos de la terapia periodontal es corregir quirúrgicamente las recesiones; se han descrito una variedad de enfoques quirúrgicos como métodos efectivos para cubrir las superficies radiculares expuestas, siendo el injerto libre de tejido conectivo una de las técnicas que hoy en día ofrece un buen porcentaje de éxito y predecibilidad. Se presenta el caso de un paciente con retracción del margen gingival en el maxilar superior derecho; se describe el procedimiento quirúrgico usando una técnica bilaminar empleando un injerto subepitelial de tejido conectivo bajo un colgajo de espesor parcial posicionado coronalmente, y se obtienen buenos resultados estéticos y cobertura radicular.

  14. Effects of Sm addition on microstructure and mechanical properties of a Mg-10Y alloy

    Directory of Open Access Journals (Sweden)

    Li Quanan

    2014-01-01

    Full Text Available To further increase the mechanical properties, 0.5wt.% Sm was introduced to a Mg-10Y alloy in this study. The effects of Sm addition on the microstructures and mechanical properties of the Mg-10Y alloy, especially the aged Mg-10Y alloy, were investigated. The microstructure observation and tensile tests were performed by using an optical microscopy, a scanning electron microscopy and a universal material testing machine, respectively. The phase analysis was performed using X-ray diffractometer. The results show that the 0.5wt.% Sm addition can not only promote the formation of fine and dispersed Mg24Y5 phases, but also improve their morphology and distribution; it also increases the thermal stability of Mg24Y5 phases. Sm addition is seen to increase the ultimate tensile strength of Mg-10Y alloy at elevated temperatures (200, 250, 300 and 350 ℃, while decrease the elongation. But the elongation is still up to 7.5% even at 350 ℃. In the range of 250 ℃ to 300℃, the ultimate tensile strength of the alloy reaches its maximum (with a range average of 235 MPa and is not sensitive to the temperature change, which is very useful to the application of heat-resistant magnesium alloys. Even at 350 ℃, the ultimate tensile strength of Mg-10Y-0.5Sm is still up to 155 MPa. Considering both of the ultimate tensile strength and elongation, the maximum application temperature of the Mg-10Y-0.5Sm alloy can be up to 300 ℃. The strengthening mechanisms of Mg-10Y-0.5Sm alloy are mainly attributed to dispersion strengthening of Mg24Y5 phase particles with a certain solubility of Sm and grain refinement strengthening of α-Mg matrix.

  15. Preparation, microstructure and magnetic properties of Sm(Co,Hf){sub 7}/Co nanocomposite particles by polyol method

    Energy Technology Data Exchange (ETDEWEB)

    Bu, Shao-Jing; Duan, Xiu-Li; Han, Xu-Hao; Sun, Ji-Bing, E-mail: hbgdsjb@126.com; Chi, Xiang; Cui, Chun-Xiang

    2017-02-01

    Hard/soft Sm-Co/Co nanocomposite particles were prepared by reducing CoCl{sub 2}·6H{sub 2}O in the solution containing ball-milled Sm(Co, Hf){sub 7} particles by a simple polyol method with ethylene glycol as the solvent. Phase composition, microstructure and magnetic properties of the particles were analyzed by XRD, TEM (HRTEM) and VSM, respectively. It has been found that Sm-Co/Co core/shell structure is formed in which the Co shell is 3–5 nm in thickness and mainly exists in hcp-Co phase. At the same time, fcc-Co tends to nucleate and grow independently between Sm-Co particles. The formation mechanism of Sm-Co/Co composite particles is discussed and corresponding model is established. Sm-Co/Co composite particles perform obvious remanence enhancement effects especially after being heated at 450 °C for 15 min.

  16. Crystal structure and magnetic properties of a nitrogenated melt-spun Sm[sub 2]Fe[sub 17] compound

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Choong-Jin [Electromagnetic Materials Laboratory, Research Institute of Industrial Science and Technology, P.O. Box 135, 790-330 Pohang (Korea, Republic of); Lee, Woo-Young [Electromagnetic Materials Laboratory, Research Institute of Industrial Science and Technology, P.O. Box 135, 790-330 Pohang (Korea, Republic of); Choi, Seung-Duck [Electromagnetic Materials Laboratory, Research Institute of Industrial Science and Technology, P.O. Box 135, 790-330 Pohang (Korea, Republic of)

    1994-05-15

    Sm[sub 2]Fe[sub 17]N[sub 2.9] compound powders were prepared from parent alloys of Sm[sub 2]Fe[sub 17] which were made by both arc melting and rapid solidification processes. The cast Sm[sub 2]Fe[sub 17] contained mixed phases of SmFe[sub 3] and [alpha]-Fe, and correspondingly formed less Sm[sub 2]Fe[sub 17]N[sub x] with a rather large amount of residual [alpha]-Fe after nitrogenation. The melt-spun Sm[sub 2]Fe[sub 17] compound, however, was single phase and exhibited a negligible amount of residual [alpha]+Fe after nitrogenation. The residual amount of free iron was found to increase as a function of milling time and to impede the development of promising permanent magnetic properties. The melt-spun Sm[sub 2]Fe[sub 17]N[sub x] compound powders exhibited a coercivity value [sub i]H[sub c] of 5 kOe, which is double that of the as-cast Sm[sub 2]Fe[sub 17]N[sub x] powders and a high remanence B[sub r]=60 e.m.u. g[sup -1]. The average magnetic moment of Fe atoms in the crystal is estimated to be 2.29 [mu][sub B] and the Fe atom in the 6c site exhibits the highest magnetic moment of 2.65 [mu][sub B]. The expansion in the c axial direction of the nitrogenated crystal was found to be mainly due to extension of Sm(6c)-Fe(c) and Fe(18f)-Fe(18f) distances. ((orig.))

  17. Aplicaciones terrestres de bajo volumen con abamectin y spinosad para el control químico del minador de los cítricos en limoneros Abamectin and spinosad low volume applications to control citrus leafminer on lemon trees

    Directory of Open Access Journals (Sweden)

    Hernán Salas

    2008-07-01

    Full Text Available El minador de los cítricos, Phyllocnistis citrella, produce daños directos al afectar los brotes nuevos de las plantas jóvenes, e indirectos al permitir la entrada de la bacteria responsable de la cancrosis de los cítricos, a través de las heridas que producen las larvas en las hojas. Este daño indirecto motivó a los productores citrícolas a controlar las poblaciones del minador también en plantas adultas. El objetivo del presente trabajo fue evaluar el control de P. citrella mediante aplicaciones con bajo volumen de abamectin y spinosad, combinados con aceite mineral emulsionable. Las aplicaciones de bajo volumen se hicieron durante tres campañas consecutivas sobre plantas de limonero de siete años de edad al momento de iniciar las experiencias, usando 2 l de caldo formulado por planta. Los tratamientos evaluados fueron: abamectin (1,8 g i.a./ha, spinosad (24 g i.a./ha, ambos combinados con aceite mineral, y un testigo sin tratar. Se hicieron dos aplicaciones por campaña cada 15 días. Se extrajeron muestras semanalmente para evaluar el porcentaje de hojas con larvas vivas. Al final de la experiencia se estimó el daño foliar en brotes previamente marcados. Tanto abamectin como spinosad controlaron la plaga durante 14 días y el porcentaje de área foliar dañada fue menor a 3,5%. El control obtenido con ambos tratamientos, nos permite disponer de dos opciones de activos para el control del minador con el fin de rotar los productos y evitar posibles problemas de resistencia.The citrus leafminer, Phyllocnistis citrella, produces direct damages affecting new flushes of young trees, and indirect ones, since the wounds produced on the leaves by the leafminer represent an entry way for the bacterium responsible for citrus canker. This indirect damage has motivated citrus farmers to control leafminer on adult trees. The aim of this work was to evaluate leafminer control using low volume applications of abamectin and spinosad with mineral

  18. The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis.

    Directory of Open Access Journals (Sweden)

    Svenja Beckmann

    2010-02-01

    Full Text Available The signal transduction protein SmTK4 from Schistosoma mansoni belongs to the family of Syk kinases. In vertebrates, Syk kinases are known to play specialized roles in signaling pathways in cells of the hematopoietic system. Although Syk kinases were identified in some invertebrates, their role in this group of animals has not yet been elucidated. Since SmTK4 is the first Syk kinase from a parasitic helminth, shown to be predominantly expressed in the testes and ovary of adult worms, we investigated its function. To unravel signaling cascades in which SmTK4 is involved, yeast two-/three-hybrid library screenings were performed with either the tandem SH2-domain, or with the linker region including the tyrosine kinase domain of SmTK4. Besides the Src kinase SmTK3 we identified a new Src kinase (SmTK6 acting upstream of SmTK4 and a MAPK-activating protein, as well as mapmodulin acting downstream. Their identities and colocalization studies pointed to a role of SmTK4 in a signaling cascade regulating the proliferation and/or differentiation of cells in the gonads of schistosomes. To confirm this decisive role we performed biochemical and molecular approaches to knock down SmTK4 combined with a novel protocol for confocal laser scanning microscopy for morphological analyses. Using the Syk kinase-specific inhibitor Piceatannol or by RNAi treatment of adult schistosomes in vitro, corresponding phenotypes were detected in the testes and ovary. In the Xenopus oocyte system it was finally confirmed that Piceatannol suppressed the activity of the catalytic kinase domain of SmTK4. Our findings demonstrate a pivotal role of SmTK4 in gametogenesis, a new function for Syk kinases in eukaryotes.

  19. Effect of temperature on the luminescence of Sm{sup 3+} ions in YAM crystals

    Energy Technology Data Exchange (ETDEWEB)

    Kaczkan, M. [Institute of Microelectronics and Optoelectronics PW, ul. Koszykowa 75, 00-662 Warsaw (Poland); Boruc, Z., E-mail: z.boruc@stud.elka.pw.edu.pl [Institute of Microelectronics and Optoelectronics PW, ul. Koszykowa 75, 00-662 Warsaw (Poland); Turczyński, S. [Institute of Electronic Materials Technology, ul. Wólczyńska 133, 01-919 Warsaw (Poland); Malinowski, M. [Institute of Microelectronics and Optoelectronics PW, ul. Koszykowa 75, 00-662 Warsaw (Poland)

    2014-11-05

    Highlights: • Different concentration Sm{sup 3+}-doped Y{sub 4}Al{sub 2}O{sub 9} crystals are fabricated by μ-pulling down method. • Thermally activated {sup 4}F{sub 3/2} → {sup 6}H{sub 5/2} emission of Sm{sup 3+} in YAM is studied. • Temperature dependent quenching mechanism of the {sup 4}G{sub 5/2} luminescence is proposed. - Abstract: The spectroscopic features of samarium Sm{sup 3+} activated Y{sub 4}Al{sub 2}O{sub 9} (YAM) crystals are presented and discussed. Temperature sensing properties of Sm{sup 3+}:YAM phosphor was demonstrated over the 300–1200 K range. Temperature dependent luminescence spectra and decay curves for the {sup 4}G{sub 5/2} level of Sm{sup 3+} in YAM were measured. Ratio of the fluorescence intensities arising from the two close lying {sup 4}F{sub 3/2} and {sup 4}G{sub 5/2} levels (with energy separation of ΔE ∼ 1000 cm{sup −1}) followed a straight line pattern, which confirms the Boltzmann distribution of the population, and can be used to measure temperature. The lifetime for the {sup 4}G{sub 5/2} level in 1% Sm doped sample decreases from 1.65 to 0.08 ms with heating from room temperature to 1200 K. This behavior of decays is discussed in terms of radiative and multiphonon decays as well as cross-relaxation dependence on temperature.

  20. Photoluminescence characteristics of Sm{sup 3+}-doped Ba{sub 2}CaWO{sub 6} as new orange–red emitting phosphors

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Ruiijn [College of Science, Northwest A and F University, Yangling, Shaanxi 712100 (China); Department of Physics, Pukyong National University, Busan 608-737 (Korea, Republic of); Department of Physics, Changwon National University, Changwon 641-773 (Korea, Republic of); Mi Noh, Hyeon; Kee Moon, Byung; Chun Choi, Byung [Department of Physics, Pukyong National University, Busan 608-737 (Korea, Republic of); Hyun Jeong, Jung, E-mail: jhjeong@pknu.ac.kr [Department of Physics, Pukyong National University, Busan 608-737 (Korea, Republic of); Sueb Lee, Ho [Department of Physics, Changwon National University, Changwon 641-773 (Korea, Republic of); Jang, Kiwan, E-mail: kwjang@changwon.ac.kr [Department of Physics, Changwon National University, Changwon 641-773 (Korea, Republic of); Soo Yi, Soung [Department of Electronic Material Engineering, Silla University, Busan 617-736 (Korea, Republic of)

    2014-08-01

    The orange–red emitting Ba{sub 2}CaWO{sub 6}:xSm{sup 3+} (0.01≤x≤0.25) phosphors were synthesized via solid state reaction process. The crystal structure of the phosphor was characterized by XRD. The photoluminescence excitation and emission spectra, concentration effect were investigated. The results show an efficient energy transfer from WO{sub 6}{sup 6−} group to Sm{sup 3+} occurs. The emission spectra of the Ba{sub 2}CaWO{sub 6}:Sm{sup 3+} phosphors consisted of some sharp emission peaks of Sm{sup 3+} ions centre at 579 nm, 618 nm, 625 nm, and 675 nm. The strongest one is located at 610 nm due to {sup 4}G{sub 5/2}→{sup 6}H{sub 7/2} transition of Sm{sup 3+}, generating bright orange–red light. The optimum dopant concentration of Sm{sup 3+} ions in Ba{sub 2}CaWO{sub 6}:xSm{sup 3+} is around 5 mol% and the critical transfer distance of Sm{sup 3+} is calculated as 18 Å. The fluorescence lifetime of Sm{sup 3+} in Ba{sub 2}CaWO{sub 6}:0.05Sm{sup 3+} is 2.36 ms. The Ba{sub 2}CaWO{sub 6}:Sm{sup 3+} phosphors may be potentially used as orange–red phosphors for white light-emitting diodes. - Highlights: • A new host-sensitized Sm{sup 3+}-doped Ba{sub 2}CaWO{sub 6} phosphor was firstly synthesized. • Its structure, luminescent properties are well studied and characterized. • There exists an efficient energy transfer from WO{sub 6}{sup 6−} group to Sm{sup 3+}. • The thermal quenching properties of Ba{sub 2}CaWO{sub 6}:Sm{sup 3+} was firstly evaluated.

  1. Effects of Sm addition on electromagnetic interference shielding property of Mg-Zn-Zr alloys

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Chubin [Chongqing University, College of Materials Science and Engineering, National Engineering Research Center for Magnesium Alloy, Chongqing (China); Gannan Normal University, Jiangxi Provincial Engineering Research Center for Magnesium Alloy, Ganzhou (China); Pan, Fusheng; Chen, Xianhua [Chongqing University, College of Materials Science and Engineering, National Engineering Research Center for Magnesium Alloy, Chongqing (China); Luo, Ning [Gannan Normal University, Jiangxi Provincial Engineering Research Center for Magnesium Alloy, Ganzhou (China)

    2017-06-15

    The electromagnetic interference (EMI) shielding of Sm-containing magnesium alloys in the 30-1500 MHz testing frequency range was investigated by coaxial cable method. The results demonstrated that Mg-3Zn alloys displayed the best electromagnetic shielding property. When 0.5 wt% of Zr was added for crystal grain refinement, the shielding effectiveness (SE) was apparently reduced. The addition of the rare earth element Sm in ZK magnesium alloys can improve the electromagnetic interference shielding of magnesium alloys. The main reason for the differences in electromagnetic interference shielding of magnesium alloys was the change in conductivity. The addition of Zr in Mg-Zn alloys can refine the grains and consequently improve the grain boundary area significantly. Therefore, the number of irregularly arranged atoms at the grain boundaries increased, decreasing the conductivity of magnesium alloys and leading to a decrease in the electromagnetic interference shielding. Following the Sm addition, the Mg-Zn-Sm phase was precipitated at the grain boundaries and in cores. The precipitation of Sm-containing rare earth phases could consume the solid-soluted Zn atoms within the Mg, resulting in an increase in electrical conductivity and electromagnetic interference shielding improvement. (orig.)

  2. Estimación de la prevalencia del trastorno por déficit de atención con o sin hiperactividad (TDAH en población escolar de la Comunidad Autónoma de Canarias

    Directory of Open Access Journals (Sweden)

    Juan E. Jiménez

    2012-06-01

    Full Text Available Este estudio ha tenido por finalidad determinar la prevalencia del Trastorno por Déficit de Atención con o sin Hiperactividad (TDAH en la Comunidad Autónoma de Canarias, en la población de 6 a 12 años. Para ello, el muestreo utilizado fue polietápico estratificado y proporcional por conglomerados. Los estratos fueron el tipo de colegio, la y el nivel educativo, y los conglomerados fueron los colegios. A partir de una muestra de estudio de 118.467 alumnos escolarizados en centros ordinarios, se obtuvo una muestra al azar de 2.395 alumnos. Se utilizaron las escalas Attention-Deficit/Hiperactivity Disorder Rating Scales IV (ADHD RS-IV modificadas para padres y maestros. Se encontró una tasa global de prevalencia del 4.9%, de los cuales el 3.1% fueron del subtipo inatento, el 1.1% hiperactivo, y el 0.7% combinado. Solo se encontraron diferencias significativas en función del sexo, donde la incidencia fue superior en varones. Las implicaciones educativas y socio sanitarias de los hallazgos encontrados nos sugieren la importancia de llevar a cabo una identificación, diagnóstico y tratamiento temprano, lo que ayudará a que los niños identificados con TDAH puedan desarrollar todo su potencial, y con ello una reducción importante del gasto público.

  3. Relación entre adherencia al tratamiento antirretroviral y subpoblaciones linfocitarias en niños con HIV/Sida

    Directory of Open Access Journals (Sweden)

    Jeannette Balbaryski

    2013-08-01

    Full Text Available El curso de la infección por HIV se caracteriza principalmente por una depleción grave de los linfocitos TCD4+ y una activación inmune marcada, hallazgos centrales que conducen a variaciones numéricas y fenotípicas de las poblaciones linfocitarias TCD4+. El tratamiento antirretroviral (TARV combinado ha modificado sustancialmente el curso de la infección por HIV, y la correcta adherencia al mismo resulta en una disminución de la carga viral a niveles indetectables, y a un incremento significativo en la repoblación de los linfocitos T periféricos. En este trabajo se evaluó en 28 niños HIV (+ la relación entre los cambios en los niveles de las poblaciones linfocitarias y la adherencia al TARV, luego de 9 meses en promedio de iniciado el mismo. El grupo de 18 niños con buena adherencia, superior al 95%, presentó un aumento significativo en los porcentajes de células naive CD4+CD45RA+CD62L+ y un descenso en las células de memoria central CD4+CD45RA-CD62L+, entre ambos momentos del seguimiento. Por el contrario, los 10 niños con fallas en la adherencia no mostraron diferencias significativas en los niveles de tales poblaciones. La buena adherencia al TARV produce el rápido y significativo descenso de la replicación viral lo cual se asocia a la progresiva reconstitución cuantitativa y funcional del sistema inmune.

  4. Småföretagarnas Bootstrapping : en kvantitativ studie om hur småföretagens bootstrappinganvändning förklaras utifrån företagens livscykel

    OpenAIRE

    Karlsson, Anton; Nilsson, Pontus

    2017-01-01

    Arbetslösheten i Sverige uppgick under 2017 års första månad till 7,3 procent. En aktuell faktor för att minska arbetslösheten är entreprenörskap. Entreprenörskap är en viktig del i utvecklingen för att driva småföretag. Småföretagen svarar för en betydande del av Sveriges sysselsättning, men lider av låg överlevnadsgrad. För att öka sannolikheten för överlevnad använder många småföretag olika bootstrappingmetoder. Syftet med bootstrapping är att finna lösningar på resursbehov och kan därför ...

  5. Thermal decomposition of the Fe17 Sm2 N3 phase

    International Nuclear Information System (INIS)

    Cabral, F.A.O.; Gama, S.; Morais, E. de; Sanjurjo, N.L.; Ribeiro, C.A.

    1996-01-01

    We studied the high temperature decomposition mechanism for the Fe 17 Sm 2 N 3 phase using several different experimental techniques, as thermomagnetic and thermogravimetric analyses. Our results slow that the decomposition occurs in a two step scheme. In the first reaction we have the formation of Sm N and a solid solution of nitrogen in iron. In the second step, this solid solution degases, and we observe the evolution of nitrogen over a broad temperature range. (author)

  6. Production of SmCo5 alloy by calciothermic reduction of samarium oxide

    International Nuclear Information System (INIS)

    Krishnan, T.S.; Gupta, C.K.

    1988-01-01

    Among the established permanent magnets, SmCo 5 magnet occupies the foremost position as it offers a unique combination of high energy product, coercivity and curie temperature. The SmCo 5 magnets are thus extensively used for high field applications. These are also best suited for use in environments where high demagnetizing field and high temperature are operative. Also, for applications where high performance and miniaturization are the over-riding considerations, the choice again falls on SmCo 5 magnets. The main deterrent to the widespread use of SmCo 5 magnet is its high cost. Both samarium and cobalt metals are high priced, and the magnets prepared from their directly melted alloy are thus naturally very expensive. An alternate process involving calcium reduction of their oxide intermediates has, therefore, been studied and the alloy prepared by this process has been evaluated and found satisfactory for magnet production. The process essentially involves compaction of the charge mix containing samarium oxide, cobalt oxide (or metal) and calcium metal and reduction of the charge compact at 1000-1300 degrees C in hydrogen atmosphere, followed by water and acid leaching, drying and classification

  7. Surface properties of SmB{sub 6} from X-ray photoemission spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Heming, Nadine; Treske, Uwe; Knupfer, Martin; Koitzsch, Andreas [Institute for Solid State Research, IFW Dresden (Germany); Buechner, Bernd [Institute for Solid State Research, IFW Dresden (Germany); Institut fuer Festkoerperphysik, TU Dresden (Germany); Inosov, Dmytro [Institut fuer Festkoerperphysik, TU Dresden (Germany); Shitsevalova, Natalya Y.; Filipov, Volodymyr B. [Institute for Problems of Material Science, Kiev (Ukraine); Kraus, Stephan [BESSY II, Berlin (Germany)

    2015-07-01

    The mixed valence compound SmB{sub 6} has been well known for its anomalous low temperature resistivity behavior for decades: At temperatures below 50 K, SmB{sub 6} transmutes from a metal to an insulator but shows residual resistivity for temperatures less than 5 K. Renewed interest in this material comes from theoretical proposals, predicting topological protected surface states making this compound the prime candidate for the new material class of ''Topological Kondo Insulators''. Indeed, elaborate transport experiments have evidenced that the residual conductivity occurs only at the surface. However, it is generally well known that the surface of f-systems undergoes valence changes and reconstructions, which may also influence the surface properties of this material. Applying surface sensitive soft X-ray photoemission spectroscopy, we have investigated the surface properties of freshly cleaved SmB{sub 6} single crystals at 15 K monitoring the Sm valance, the chemical state of boron as well as the surface stoichiometry, and also the development of these over time and with increased temperature: We have found that the surface shows an unexpected complexity stemming from both intrinsic and extrinsic changes.

  8. Effect of samarium (Sm) addition on the microstructures and mechanical properties of Al–7Si–0.7Mg alloys

    International Nuclear Information System (INIS)

    Qiu, Hongxu; Yan, Hong; Hu, Zhi

    2013-01-01

    Highlights: •Sm affected the secondary dendrite arm spacing of Al–7Si–0.7Mg alloy. •The coarse plate-like eutectic silicon was fully modified into a fine branched and particle structure when 0.6 wt.% Sm added. •The tensile properties were enhanced by the addition of Sm. •Sm has marked effects on eutectic temperature and the latent heat ΔH R on remelting behavior. •The morphology and chemical composition of Sm-rich intermetallics were studied. -- Abstract: The effects of samarium (Sm) additions (0–0.9 wt.%) on the microstructures and mechanical properties of Al–7Si–0.7Mg alloys have been studied in this article. The microstructures of the as-cast samples were examined by optical microscopy (OM) and scanning electron microscopy (SEM). The experimental results indicated that the rare earth Sm affected the secondary dendrite arm spacing (SDAS) of Al–7Si–0.7Mg alloy. And it was found that Sm had great modification effects on the microstructures of eutectic silicon. When 0.6 wt.% Sm was added to the alloy, the coarse plate-like eutectic silicon was fully modified into a fine fibrous structure; the dendrites of Al–7Si–0.7Mg alloy was best refined. The mechanical properties were investigated by tensile test. The findings indicate that the tensile properties and elongation were improved by the addition of Sm. And a good combination of ultimate tensile strength (215 MPa) and elongation (3.3%) was obtained when the Sm addition was up to 0.6 wt.%. Furthermore the results of thermal analysis reveal that Sm addition had marked effects on eutectic temperature and the latent heat ΔH R on remelting behavior

  9. Bone uptake by di and tetraphosphonates labeled with Rhenium-188

    International Nuclear Information System (INIS)

    Faintuch, B.L.; Osso, J.A. Jr.; Muramoto, E.; Faintuch, S.

    2002-01-01

    MDP (methylenediphosphonate) and HEDP (hydroxyethylidenediphosphonate), both diphosphonates, and EDTMP (ethylenediamine tetramethylene phosphonic acid) a tetraphosphonate ligand, have been labeled with 188 Re for use in metastatic bone-pain palliation. The aim of this study was a comparison between the three complexes 188 Re-MDP, 188 Re-HEDP and 188 Re-EDTMP concerning the complexation conditions, in order to achieve maximum yield, stability and bone uptake. Methods: MDP was dissolved in water and HEDP and EDTMP were dissolved in NaOH 1N followed by decreasing pH with HCl 1N. To all mixtures stannous chloride and 188 ReO 4 were added in a nitrogen atmosphere. The preparations were heated in a boiling water bath for 15 min. The yields as well as the radiochemical stability were estimated by ITLC. Different concentrations of phosphonates and stannous chloride were evaluated. Biodistribution studies in swiss mice were done for the three 188 Re-phosphonates that presented the best radiochemical yield. Results: For 188 Re-MDP and 188 Re-HEDP the optimal ligand concentration for maximum complexation was 30 mg whereas for 188 Re-EDTMP, it was 40 mg. The best amount of SnCl 2 .2H 2 O was 2 mg/mL for MDP, 3 mg/mL for HEDP and 1 mg/mL for EDTMP. In these conditions the three complexes showed a complexation yield above 95%. All of them presented 4-hour radiochemical stability without the need for ascorbic acid solution, but for 24 hours this stability existed only in the presence of that substance otherwise re-oxidation of 188 Re occurred. All products showed a great uptake by the kidneys. 188 Re-EDTMP had the greatest uptake by the bone (3.13 ± 0.18% ID/g) followed by 188 Re-MDP (1.18 ± 0.05%ID/g) and 188 Re-HEDP (1.03 ± 0.12 %ID/g), 4 hour postinjection. 188 Re-EDTMP displayed a bone/muscle ratio of 28.5, 188 Re-MDP 4.9 and 188 Re-HEDP 4.9. Conclusion: 188 Re-EDTMP demonstrated the best potential as a radiopharmaceutical for bone cancer pain relief, encouraging further

  10. Soil Moisture Active Passive Mission L4_SM Data Product Assessment (Version 2 Validated Release)

    Science.gov (United States)

    Reichle, Rolf Helmut; De Lannoy, Gabrielle J. M.; Liu, Qing; Ardizzone, Joseph V.; Chen, Fan; Colliander, Andreas; Conaty, Austin; Crow, Wade; Jackson, Thomas; Kimball, John; hide

    2016-01-01

    During the post-launch SMAP calibration and validation (Cal/Val) phase there are two objectives for each science data product team: 1) calibrate, verify, and improve the performance of the science algorithm, and 2) validate the accuracy of the science data product as specified in the science requirements and according to the Cal/Val schedule. This report provides an assessment of the SMAP Level 4 Surface and Root Zone Soil Moisture Passive (L4_SM) product specifically for the product's public Version 2 validated release scheduled for 29 April 2016. The assessment of the Version 2 L4_SM data product includes comparisons of SMAP L4_SM soil moisture estimates with in situ soil moisture observations from core validation sites and sparse networks. The assessment further includes a global evaluation of the internal diagnostics from the ensemble-based data assimilation system that is used to generate the L4_SM product. This evaluation focuses on the statistics of the observation-minus-forecast (O-F) residuals and the analysis increments. Together, the core validation site comparisons and the statistics of the assimilation diagnostics are considered primary validation methodologies for the L4_SM product. Comparisons against in situ measurements from regional-scale sparse networks are considered a secondary validation methodology because such in situ measurements are subject to up-scaling errors from the point-scale to the grid cell scale of the data product. Based on the limited set of core validation sites, the wide geographic range of the sparse network sites, and the global assessment of the assimilation diagnostics, the assessment presented here meets the criteria established by the Committee on Earth Observing Satellites for Stage 2 validation and supports the validated release of the data. An analysis of the time average surface and root zone soil moisture shows that the global pattern of arid and humid regions are captured by the L4_SM estimates. Results from the

  11. CCSDS SM and C Mission Operations Interoperability Prototype

    Science.gov (United States)

    Lucord, Steven A.

    2010-01-01

    This slide presentation reviews the prototype of the Spacecraft Monitor and Control (SM&C) Operations for interoperability among other space agencies. This particular prototype uses the German Space Agency (DLR) to test the ideas for interagency coordination.

  12. Influence of annealing and nitrogenation on structure and magnetic properties of mechanically alloyed Sm-Fe powders

    International Nuclear Information System (INIS)

    Teresiak, A.; Kubis, M.; Mattern, N.; Wolf, M.; Mueller, K.-H.

    1998-01-01

    Sm-Fe-N compounds were prepared by mechanical alloying, subsequent annealing and nitrogenation. For crystal structure investigations of the non-equilibrium phases Sm 2 Fe 17+x and Sm 2 Fe 17+x N y , respectively, formed at the various annealing temperatures T A , XRD with following Rietveld analysis was used. For T A between 600 C and 750 C a modified hexagonal TbCu 7 structure (space group P6/mmm) was found in which the Fe(2c) site is replaced by the partially (1/3) and randomly occupied Fe(61) site. The approximated composition is SmFe 8.8-9.0 . The nitrogenated alloys crystallize in the same structure for 600 C A A ≤ 900 C a disordered modified Th 2 Zn 17 structure (space group R anti 3m) was found that is formed by introducing additional Fe (6c) and Sm(3a) positions. The degree of order of the Sm- and Fe-atoms in c-direction increases with increasing annealing temperature. The completely ordered stoichiometric Sm 2 Fe 17 structure could not be reached by annealing the ball milled elemental powders. The nitrided alloys already form this intermediate structure at T A = 750 C. The interstitial nitrogen occupies the 9e site. The estimated nitrogen content is higher in the hexagonal phases than in the rhombohedral phase. Optimum magnetic properties, in particular a coercitivity μ 01 H C = 3.7 T and a good squareness of the demagnetization curve, were obtained for T A = 750 C. Here we found a nitrogen content of y = 3 for Sm 2 Fe 17+x N y . (orig.)

  13. Contribución al tratamiento psicológico y farmacológico en el TDAH: su relevancia neuropsicológica

    OpenAIRE

    Russo Prada, Ana Raquel

    2016-01-01

    [ES] Este estudio se realizó en una muestra constituida por 38 niños con Trastorno por Déficit de Atención con Hiperactividad (TDAH), combinado e inatento, y trastornos comórbidos añadidos, con una media de 8.61± 1.50 años. También han participado 26 padres y 38 madres, con una media, respectivamente, de 43.19± 6.55 y de 38.47± 6.55 años. Tomándose como objetivos determinar la eficacia de los tratamientos e, identificar las variables predictoras de la respuesta terapéutica, se evaluaron a los...

  14. Study of 148-152Sm nuclei employing γ - derived from B(E2) values and level energies

    International Nuclear Information System (INIS)

    Sharma, Aparna; Varshney, A.K.; Singh, M.; Gupta, D.K.; Singh, Yuvraj; Gupta, K.K.; Bihari, Chhail; Varshney, Mani

    2011-01-01

    The study of samarium nuclei has been a challenging theoretical problem, since they lie in the range from near spherical to well deformed shapes. 148 Sm was believed to be basically spherical while 154 Sm is thought to be well deformed nucleus and 150-15 '2Sm are transitional nuclei

  15. 153Sm-HM for arthritic knee pain. Estimated dosimetry

    International Nuclear Information System (INIS)

    Hardy-Pérez, Alberto E.; Torres-García, Eugenio; Mitsoura, Eleni; Jiménez-Mancilla, Nallely P.; Arteaga-de-Murphy, Consuelo; Pedraza-López, Martha

    2012-01-01

    Osteoarthritis is the most common type of arthropathy and after cardiovascular diseases is the most disabling disease in developing countries. The dosimetry for the clinical application of 153-samarium-hydroxymacroaggregates ( 153 Sm-HM) for radiation synovectomy (RSV) and palliative treatment for arthritic pain, as far as we know, has not been reported. The aim of this research was to estimate the radiation dose necessary for synovial ablation and pain palliation with minimum risk to the patient. 153 Sm-HM (370 MBq) was administered intra-articularly in a patient with severe knee pain and hindered motility. Regions of interest drawn on sequential, conjugated, anterior and posterior scintigraphy images were used to obtain the respective activity. The data was entered into a knee joint histological-geometric model designed with micrometric dimensions to represent the synovial cell layers. The Monte Carlo code was used to calculate the absorbed dose in each of the 12 model-cells representing the distance from the synovial liquid to the cartilage or bone. The absorbed dose in the synovial cavity was 114 Gy which is sufficient energy for RSV. The treated patient referred little pain and higher motility with no adverse reactions. 153 Sm-HM is a potentially valid radiopharmaceutical for RSV, which effectively palliates knee pain.

  16. First-order-reversal-curve analysis of exchange-coupled SmCo/NdFeB nanocomposite alloys

    International Nuclear Information System (INIS)

    Pan, Mingxiang; Zhang, Pengyue; Ge, Hongliang; Yu, Nengjun; Wu, Qiong

    2014-01-01

    Exchange-coupled SmCo 5 /Nd 2 Fe 14 B nanocomposite magnets have been fabricated by ball milling of the micrometer sized SmCo 5 and Nd 2 Fe 14 B powders. The influence of Nd 2 Fe 14 B content on the microstructure and magnetic properties of these hybrid alloys was investigated. The alloys that show strong intergrain exchange-coupling behavior with (BH) max =2.95 MGOe was obtained when the two hard phases are well coupled. A first-order-reversal-curve (FORC) analysis was performed for both SmCo 5 single-phase magnet and SmCo 5 /Nd 2 Fe 14 B hybrid magnet; the FORC diagrams results show two major peaks for the hybrid magnets. In both cases, the magnetization reversal behaviors for these alloys were discussed in detail and are consistent with the results of δM plots. - Highlights: • Exchange-coupled SmCo 5 /Nd 2 Fe 14 B nanocomposite magnets were studied. • Magnetization reversal behaviors of the hybrid magnet were discussed. • The FORCs analysis is taken to identify the optimal conditions for hybrid magnet

  17. Model SM-1 ballast density gauge

    International Nuclear Information System (INIS)

    Gao Weixiang; Fang Jidong; Zhang Xuejuan; Zhang Reilin; Gao Wanshan

    1990-05-01

    The ballast density is one of the principal parameters for roadbed operating state. It greatly affects the railroad stability, the accumulation of railroad residual deformation and the amount of work for railroad maintenance. SM-1 ballast density gauge is designed to determine the density of ballast by using the effect of γ-ray passed through the ballast. Its fundamentals, construction, specifications, application and economic profit are described

  18. Molecular Characterization of the Schistosoma mansoni Zinc Finger Protein SmZF1 as a Transcription Factor

    Science.gov (United States)

    D'Astolfo, Diego S.; Cardoso, Fernanda C.; Rajão, Matheus A.; Mourão, Marina M.; Gava, Elisandra; Oliveira, Sérgio C.; Macedo, Andréa M.; Machado, Carlos R.; Pena, Sérgio D. J.; Kitten, Gregory T.; Franco, Glória R.

    2009-01-01

    Background During its development, the parasite Schistosoma mansoni is exposed to different environments and undergoes many morphological and physiological transformations as a result of profound changes in gene expression. Characterization of proteins involved in the regulation of these processes is of importance for the understanding of schistosome biology. Proteins containing zinc finger motifs usually participate in regulatory processes and are considered the major class of transcription factors in eukaryotes. It has already been shown, by EMSA (Eletrophoretic Mobility Shift Assay), that SmZF1, a S. mansoni zinc finger (ZF) protein, specifically binds both DNA and RNA oligonucleotides. This suggests that this protein might act as a transcription factor in the parasite. Methodology/Principal Findings In this study we extended the characterization of SmZF1 by determining its subcellular localization and by verifying its ability to regulate gene transcription. We performed immunohistochemistry assays using adult male and female worms, cercariae and schistosomula to analyze the distribution pattern of SmZF1 and verified that the protein is mainly detected in the cells nuclei of all tested life cycle stages except for adult female worms. Also, SmZF1 was heterologously expressed in mammalian COS-7 cells to produce the recombinant protein YFP-SmZF1, which was mainly detected in the nucleus of the cells by confocal microscopy and Western blot assays. To evaluate the ability of this protein to regulate gene transcription, cells expressing YFP-SmZF1 were tested in a luciferase reporter system. In this system, the luciferase gene is downstream of a minimal promoter, upstream of which a DNA region containing four copies of the SmZF1 putative best binding site (D1-3DNA) was inserted. SmZF1 increased the reporter gene transcription by two fold (p≤0.003) only when its specific binding site was present. Conclusion Taken together, these results strongly support the hypothesis

  19. Investigations on optical properties of Sm{sup 3+} ion doped boro-phosphate glasses

    Energy Technology Data Exchange (ETDEWEB)

    Vijayakumar, R.; Suthanthirakumar, P.; Karthikeyan, P.; Marimuthu, K., E-mail: mari-ram2000@yahoo.com [Department of Physics, Gandhigram Rural Institute – Deemed University, Gandhigram – 624302 (India)

    2015-06-24

    The Sm{sup 3+} doped Boro-phosphate glasses with the chemical composition 60H{sub 3}BO{sub 3}+20Li{sub 2}CO{sub 3}+10ZnO+(10−x) H{sub 6}NO{sub 4}P+xSm{sub 2}O{sub 3} (where x= 0.1, 0.5, 1 and 2 in wt%) have been prepared by melt quenching technique. The prepared glasses were characterized through optical absorption and luminescence spectral measurements. The band gap energies corresponding to the direct and indirect allowed transitions and the Urbach’s energy values were estimated from the absorption spectra. Judd-Ofelt intensity parameters have been derived to predict the radiative properties of the various emission transitions. In order to identify the emission color of the prepared glasses, the emission intensities were analyzed using CIE 1931 color chromaticity diagram. The energy transfer process takes place between Sm{sup 3+}−Sm{sup 3+} ions through cross-relaxation mechanism have also been investigated and the results were discussed and reported.

  20. Magnetic leverage effects in amorphous SmCo/CoAlZr heterostructures

    International Nuclear Information System (INIS)

    Procter, R. A.; Hase, T. P. A.; Magnus, F.; Andersson, G.; Hjörvarsson, B.; Sánchez-Hanke, C.

    2015-01-01

    Although magnetic heterostructures are the basis of many magnetic technologies, the mechanisms involved in magnetization reversals in such structures are not fully understood, especially in amorphous multilayers. Here, we report on the SmCo/CoAlZr system and exploit resonant magnetic x-ray scattering to probe the element specific magnetization reversals. When combined into a tri-layer structure, two different switching fields and reversal mechanisms are observed for the Sm and Co sub-lattices. We argue that the decoupling of the sub-lattices arises from the local distribution of atomic species within the amorphous matrix leading to a strong magnetic leverage effect and exchange pinning. The decoupling arises due to strong interactions between regions of high Co density which span the interface. The relatively sparse interactions between Sm and Co induce a localized pinning of the Co-rich areas, resulting in an exchange bias in minor loops and an enhanced coercivity