WorldWideScience

Sample records for skb candidate area

  1. Alternative modelling of brittle structures in a sub-area of the SKB candidate area at Forsmark, eastern Sweden

    International Nuclear Information System (INIS)

    Askling, Per; Tiren, Sven A.; Beckholmen, Monica; Straeng, Thomas

    2008-11-01

    One way to test the confidence of a presented model is to construct an alternative model. Such work is cognitive process of skill acquisition and also a process of understanding data in the sense of sorting and classifying data. This is of particular interest for the Swedish Radiation Safety Authority (SSM) in their technical review of SKB's on-going site investigation programme for potential repository sites. In this study, an alternative brittle deformation model of a selected part of the SKB candidate area in eastern Sweden was constructed. The input data set was obtained from SKB's database SICADA and is a selected set of data from five cored boreholes drilled from two drill-sites and comprises geophysical borehole logs, geological core-logs, hydrological logs (PFL; Posiva Flow Log) and borehole deviation measurements. Statistical cluster analysis applied on the geophysical borehole data were used to obtain the locations of bedrock with contrasting physical characteristics similar to those of brittle deformation zones. The cluster analysis is an objective procedure, contrasting with SKB's more subjective approach to the single-hole interpretation. Thus some differences are expected which could illustrate the effect of methodology that includes subjective 'expert judgement.' and indicate the possibility of alternative interpretations. The information about brittle structures in the geological boreholes logs was sorted and classification was made according to character of the structures (all fractures, open fractures, partly open fractures, frequency, orientate on/identification of fracture sets, sections of crush rock, and alteration). A separate study was performed to relate rock alteration with structures. The resolution applied in the fracture statistics is one metre, i.e. all studied entities were expressed per metre borehole length. All clusters were structurally characterized by the fractures inside the clusters (orientation and density of fractures) and

  2. Alternative modelling of brittle structures in a sub-area of the SKB candidate area at Forsmark, eastern Sweden.

    Energy Technology Data Exchange (ETDEWEB)

    Askling, Per; Tiren, Sven A.; Beckholmen, Monica; Straeng, Thomas (Geosigma AB, Uppsala (Sweden))

    2008-11-15

    One way to test the confidence of a presented model is to construct an alternative model. Such work is cognitive process of skill acquisition and also a process of understanding data in the sense of sorting and classifying data. This is of particular interest for the Swedish Radiation Safety Authority (SSM) in their technical review of SKB's on-going site investigation programme for potential repository sites. In this study, an alternative brittle deformation model of a selected part of the SKB candidate area in eastern Sweden was constructed. The input data set was obtained from SKB's database SICADA and is a selected set of data from five cored boreholes drilled from two drill-sites and comprises geophysical borehole logs, geological core-logs, hydrological logs (PFL; Posiva Flow Log) and borehole deviation measurements. Statistical cluster analysis applied on the geophysical borehole data were used to obtain the locations of bedrock with contrasting physical characteristics similar to those of brittle deformation zones. The cluster analysis is an objective procedure, contrasting with SKB's more subjective approach to the single-hole interpretation. Thus some differences are expected which could illustrate the effect of methodology that includes subjective 'expert judgement.' and indicate the possibility of alternative interpretations. The information about brittle structures in the geological boreholes logs was sorted and classification was made according to character of the structures (all fractures, open fractures, partly open fractures, frequency, orientate on/identification of fracture sets, sections of crush rock, and alteration). A separate study was performed to relate rock alteration with structures. The resolution applied in the fracture statistics is one metre, i.e. all studied entities were expressed per metre borehole length. All clusters were structurally characterized by the fractures inside the clusters (orientation and

  3. SKB annual report 1992

    International Nuclear Information System (INIS)

    1993-05-01

    This is the annual report on the activities of the Swedish Nuclear Fuel and Waste Management Co, SKB. It contains in part 1 an overview of SKB activities in different fields. Part 2 gives a description of the research and development work on nuclear waste disposal performed during 1992. Lectures and publications during 1992 as well as reports issued in the SKB technical report series are listed in part 4. Part 5 contains the summaries of all technical reports issued during 1992. SKB is the owner of CLAB, the Central Facility for Interim Storage of Spent Nuclear Fuel, located at Oskarshamn. CLAB was taken into operation in July 1985 and to the end of 1992 in total 1684 tonnes of spent fuel (measured as uranium) has been received. Transportation from the nuclear site to CLAB is made by a special ship, M/S Sigyn. At Forsmark the final repository for Radioactive Waste -SFR- was taken in operation in April 1988. At the end of 1992 a total of 11000 m 3 of waste have been deposited in SFR. The total cost for R and D during 1992 was 192.3 MSEK of which 24.8 MSEK came from participants outside Sweden. Some of the main areas for SKB research are: groundwater movements, bedrock stability, groundwater chemistry and nuclide migration, method and instruments for in situ characterization of crystalline bedrock, characterization and leaching of spent nuclear fuel, properties of bentonite for buffer, backfilling and sealing, radionuclide transport in biosphere and dose evaluations, development of performance and safety assessment methodology and assessment models, construction of an underground research laboratory. Cost calculations for the total nuclear waste management system, including decommissioning of all reactors, are updated annually. The total cost is estimated to 55 billion SEK

  4. Long-term development of the super-regional area of Olkiluoto/Forsmark/Laxemar. Minutes from the Posiva and SKB workshop

    Energy Technology Data Exchange (ETDEWEB)

    Lindborg, Tobias; Rubio Lind, Lotta (eds.)

    2006-12-15

    The siting program for a repository of spent fuel currently collects large data sets from the surface ecosystem, as well from the geosphere. For Sweden, the program for the surface ecosystem is described in the reports SKB-R--00-19 and SKB-R--03-06, and the general siting program in SKB-TR--01-29. Correspondingly, for Finland the Posiva programme is described in POSIVA--03-02, POSIVA--03-05 and POSIVA--05-03. The collected data is used in different kinds of modelling, mainly for the safety assessment for the repository and for environmental impact assessment (EIA). Since, Posiva and SKB (the nuclear waste management companies of Finland and Sweden, resp.) are sharing the same super regional area in terms of historical and future development, it is of great importance to coordinate the descriptions of this area and its properties to avoid discrepancies and to make better use of the data collected at both sites/countries. In order to accomplish this collaboration, a consensus was attained on which properties/parameters/variables that were important to consider and it was decided which references, models and equations to be use in the site descriptions. Furthermore, possible gaps in the understanding of the site were identified and discussed. A plan on how to handle these gaps was made, i.e. do we need to initiate more research? Participants from the site investigation program, the analysis group, safety assessment and research from Posiva and SKB were invited to the workshop. Besides the major aim of the workshop, other important objectives were to enhance the communication between Posiva and SKB, increase the awareness of different issues handled at the sites/subject area, and to build a better understanding for the models. Additional it should be mentioned that this is only a record of initial discussions and there might be changes in the practical implementation due to e.g. change of focus with advances in the programmes. The workshop and this report of the

  5. SKB annual report 1988

    International Nuclear Information System (INIS)

    1989-12-01

    This is the annual report on the activities of the Swedish Nuclear Fuel and Waste Management Co, SKB. It contains in part 1 an overview of SKB activities in different fields. Part 2 gives a description of the research and development work on nuclear waste disposal performed during 1988. Lectures and publications during 1988 as well as reports issued in the SKB technical report series are listed in part 3. Part 4 contains the summaries of all technical reports issued during 1988. SKB is in charge of a comprehensive research and development program on geological disposal of nuclear waste. The total cost for R and D during 1988 was 123.4 MSEK of which 19.3 MSEK came from participants outside Sweden

  6. SKB Annual Report 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-05-01

    This is the annual report of the Swedish Nuclear Fuel and Waste Management Co (SKB). Part 1 of the report contains an overview of the SKB activities in different fields, and part 2 gives a description of the research and development work on nuclear waste disposal performed during 1996. Lectures and publications as well as reports issued during 1996 are listed in part 3, and summaries of the reports are listed in part 4. The task of SKB is to transport, store and dispose of the spent nuclear fuel and radioactive wastes from the nuclear power plants and to perform the research and development and other measures necessary for this work. SKB is the owner of CLAB, the Central Interim Storage Facility for spent fuel, located at Oskarshamn. CLAB was taken into operation in July 1985 and by the end of 1996 about 2500 tons of spent fuel have been received. At Forsmark the Final Repository for Radioactive Operational Waste (SFR) was taken into operation in April 1988. The repository is situated in crystalline rock under the Baltic Sea. SFR has currently a capacity of about 60000 m{sup 3} or waste. At the end of 1996 at total of 21000 m{sup 3} of waste has been deposited. Transportation from the reactor sites to CLAB and SFR is made by a specially designed ship, M/S Sigyn. The total cost for R,D and D during 1996 amounted to 124 MSEK (about 15 MUSD).

  7. SKB Annual Report 1996

    International Nuclear Information System (INIS)

    1997-05-01

    This is the annual report of the Swedish Nuclear Fuel and Waste Management Co (SKB). Part 1 of the report contains an overview of the SKB activities in different fields, and part 2 gives a description of the research and development work on nuclear waste disposal performed during 1996. Lectures and publications as well as reports issued during 1996 are listed in part 3, and summaries of the reports are listed in part 4. The task of SKB is to transport, store and dispose of the spent nuclear fuel and radioactive wastes from the nuclear power plants and to perform the research and development and other measures necessary for this work. SKB is the owner of CLAB, the Central Interim Storage Facility for spent fuel, located at Oskarshamn. CLAB was taken into operation in July 1985 and by the end of 1996 about 2500 tons of spent fuel have been received. At Forsmark the Final Repository for Radioactive Operational Waste (SFR) was taken into operation in April 1988. The repository is situated in crystalline rock under the Baltic Sea. SFR has currently a capacity of about 60000 m 3 or waste. At the end of 1996 at total of 21000 m 3 of waste has been deposited. Transportation from the reactor sites to CLAB and SFR is made by a specially designed ship, M/S Sigyn. The total cost for R,D and D during 1996 amounted to 124 MSEK (about 15 MUSD)

  8. SKB annual report 1987

    International Nuclear Information System (INIS)

    1988-05-01

    The annual report on the activities of the Swedish Nuclear Fuel and Waste Management contains in part I an overview of SKB activities in different fields. Part II gives a description of the research and development work on nuclear waste disposal performed during 1987. Lectures and publications during 1987 as well as reports issued in the SKB technical report series are listed in part III. Part IV contains the summaries of all technical reports issued during 1987. At Forsmark the first construction phase for the final repository for radioactive waste - SFR - is now completed. The repository is situated in crystalline rock under the Baltic Sea. The first construction phase includes rock caverns for 60 000 m 3 of waste. A second phase for additional 30 000 m 3 is planned to be built and commissioned around the year 2000. (orig./DG)

  9. Rock-block configuration in Uppland and the Aalands-hav basin, the regional surroundings of the SKB site in Forsmark, Sea and land areas, eastern Sweden

    International Nuclear Information System (INIS)

    Beckholmen, Monica; Tiren, Sven A.

    2010-12-01

    The Forsmark SKB site lies at the west-northwest trending shoreline in northern Uppland, sheltered from the sea by one of the larger islands in the Uppland archipelago, Graesoe. To assess the structures around Forsmark also in the sea area, the bottom structures of the Aalands-hav basin were investigated by means of depth readings from sea charts. Two rock-block maps with rock blocks at different scales were constructed and analysed for their top surface elevation. The topography in Uppland is more broken in the sea area east and northeast of Forsmark than it is on land. The major structure in the Aalands-hav basin is a westnorth- westerly line that passes southwest of Aaland, with a very steep gradient from the Aaland archipelago down to an exceptionally low sea-floor valley. On its southern side it rises in steps to a low flat basin divided into a deeper western half and a somewhat shallower eastern half. The deep west-north-westerly zone can be traced on-land past Oeregrund and Forsmark. West of Oeregrund however, the main trough swings into a north-northwesterly direction, just west of Graesoe. The southern border south of Oeregrund and Forsmark, shows a major drop in elevation northern side down. Forsmark thus lies on a ribbon with lower ground on both its southern and northern boundaries. This west-north-westerly belt is cut in two by a major north-south lineament that cuts through the archipelago between Aaland and Graesoe with a very deep canyon. This structure was seismically active in June 2006. The southern part of this line constitutes the western border of the low basin and has a steep gradient on its western side up to the Uppland mainland. The deep basin is filled with Jotnian metasediments. South of this basin, the Uppland mainland continues under water towards the east. South of Aaland an east-north-easterly ridge separates the low basin to the north from an east-west trending trough which is the eastern continuation of a major onland structure

  10. Geochemical Parameters Required from the SKB Site Characterisation Programme

    International Nuclear Information System (INIS)

    Bath, Adrian

    2002-01-01

    SKB has described its approach to site characterisation in a number of Technical Reports. One of the scientific topics in which specific information requirements and priorities are set out is geochemistry. This report for SKI examines critically whether the geochemical parameters identified in the SKB programme documents will be adequate for safety and regulatory requirements. It also examines some of the details of parameter requirements and interpretation tools that will be necessary to convert site investigation data into knowledge about chemical conditions and groundwater movements. The SKB strategy for geochemical data focuses on a small number of 'suitability indicators', primarily dissolved oxygen, pH and salinity. Their parameter requirements aim to assess those primary characteristics, as well as to acquire a wider range of data that will support those assessments and provide a broader understanding of candidate areas. An initial observation in this review that, though it is a primary suitability indicator, dissolved oxygen apparently will not be measured and instead will be inferred from other redox indicators. This raises a number of issues about sampling and monitoring measures, analytical data reliability and sensitivity, and the degree of confidence in geochemical understanding. A geochemical programme involves reconnaissance by desk study and acquisition of new data at levels of details that are appropriate to the stage of site investigations. As early as possible, a conceptual model of a candidate area should help to define the objectives of geochemical measurements on both rock and groundwater samples. It is recommended that parameters requirements should be defined and considered not only in terms of isolated measurements but more in terms of addressing broader objectives that relate to safety and also to geoscientific understanding. The safety priorities remain (e.g. dissolved oxygen) but will then be supported by an understanding of processes

  11. Geochemical Parameters Required from the SKB Site Characterisation Programme

    Energy Technology Data Exchange (ETDEWEB)

    Bath, Adrian [Intellisci Ltd., Loughborough (United Kingdom)

    2002-01-01

    SKB has described its approach to site characterisation in a number of Technical Reports. One of the scientific topics in which specific information requirements and priorities are set out is geochemistry. This report for SKI examines critically whether the geochemical parameters identified in the SKB programme documents will be adequate for safety and regulatory requirements. It also examines some of the details of parameter requirements and interpretation tools that will be necessary to convert site investigation data into knowledge about chemical conditions and groundwater movements. The SKB strategy for geochemical data focuses on a small number of 'suitability indicators', primarily dissolved oxygen, pH and salinity. Their parameter requirements aim to assess those primary characteristics, as well as to acquire a wider range of data that will support those assessments and provide a broader understanding of candidate areas. An initial observation in this review that, though it is a primary suitability indicator, dissolved oxygen apparently will not be measured and instead will be inferred from other redox indicators. This raises a number of issues about sampling and monitoring measures, analytical data reliability and sensitivity, and the degree of confidence in geochemical understanding. A geochemical programme involves reconnaissance by desk study and acquisition of new data at levels of details that are appropriate to the stage of site investigations. As early as possible, a conceptual model of a candidate area should help to define the objectives of geochemical measurements on both rock and groundwater samples. It is recommended that parameters requirements should be defined and considered not only in terms of isolated measurements but more in terms of addressing broader objectives that relate to safety and also to geoscientific understanding. The safety priorities remain (e.g. dissolved oxygen) but will then be supported by an understanding of

  12. Review of SKB's Work on Coupled THM Processes Within SR-Can. External review contribution in support of SKI's and SSI's review of SR-Can

    International Nuclear Information System (INIS)

    Rutqvist, Jonny; Tsang, Chin-Fu

    2008-03-01

    In this report, we scrutinize the work by the Swedish Nuclear Fuel and Waste Management Company (SKB) related to coupled thermal, hydrological and mechanical (THM) processes within the SR-Can project. SR-Can is SKB's preliminary assessment of long-term safety for a KBS-3 nuclear waste repository, and is a preparation stage for the SR-Site assessment, the report that will be used in SKB's application for a final repository. We scrutinize SKB's work related to THM processes through review and detailed analysis, using an independent modeling tool. The modeling tool is applied to analyze coupled THM processes at the two candidate sites, Forsmark and Laxemar, using data defined in SKB's site description models for respective sites. In this report, we first provide a brief overview of SKB's work related to analysis of the evolution of coupled THM processes as presented in SRCan, as well as supporting documents. In this overview we also identify issues and assumptions that we then analyze using our modeling tool. The overview and subsequent independent model analysis addresses issues related to near-field behavior, such as buffer resaturation and the evolution of the excavation-disturbed zone, as well as far-field behavior, such as stress induced changes in hydrologic properties. Based on the review and modeling conducted in this report, we conclude by identifying a number of areas of weaknesses, where we believe further work and clarifications are needed. Some of the most important ones are summarized below: 1) We found that SKB's calculation of peak temperature might not have been conducted for the most conservative case of extreme drying of the buffer under dry rock conditions and an unexpectedly high thermal diffusion coefficient. Our alternative analysis indicates that temperatures close to 100 might be achieved under unfavorable (and perhaps unexpected) conditions in which the buffer is dried to below 20% near the canister. We believe SKB should conduct further

  13. SKI's and SSI's review of SKB's safety report SR-Can

    International Nuclear Information System (INIS)

    Dverstorp, Bjoern; Stroemberg, Bo

    2008-03-01

    This report summarises SKI's and SSI's joint review of the Swedish Nuclear Fuel and Waste Management Co's (SKB) safety report SR-Can (SKB TR-06-09). SR-Can is the first assessment of post-closure safety for a KBS-3 spent nuclear fuel repository at the candidate sites Forsmark and Laxemar, respectively. The analysis builds on data from the initial stage of SKB's surface-based site investigations and on data from full-scale manufacturing and testing of buffer and copper canisters. SR-Can can be regarded as a preliminary version of the safety report that will be required in connection with SKB's planned licence application for a final repository in late 2009. The main purpose of the authorities' review is to provide feedback to SKB on their safety reporting as part of the pre-licensing consultation process. However, SR-Can is not part of the formal licensing process. In support of the authorities' review three international peer review teams were set up to make independent reviews of SR-Can from three perspectives, namely integration of site data, representation of the engineered barriers and safety assessment methodology, respectively. Further, several external experts and consultants have been engaged to review detailed technical and scientific issues in SR-Can. The municipalities of Oesthammar and Oskarshamn where SKB is conducting site investigations, as well NGOs involved in SKB's programme, have been invited to provide their views on SR-Can as input to the authorities' review. Finally, the authorities themselves, and with the help of consultants, have used independent models to reproduce part of SKB's calculations and to make complementary calculations. All supporting review documents are published in SKI's and SSI's report series. The main findings of the review are: -SKB's safety assessment methodology is overall in accordance with applicable regulations, but part of the methodology needs to be further developed for the licence application. -SKB's quality

  14. Review of SKB's Code Documentation and Testing

    International Nuclear Information System (INIS)

    Hicks, T.W.

    2005-01-01

    SKB is in the process of developing the SR-Can safety assessment for a KBS 3 repository. The assessment will be based on quantitative analyses using a range of computational codes aimed at developing an understanding of how the repository system will evolve. Clear and comprehensive code documentation and testing will engender confidence in the results of the safety assessment calculations. This report presents the results of a review undertaken on behalf of SKI aimed at providing an understanding of how codes used in the SR 97 safety assessment and those planned for use in the SR-Can safety assessment have been documented and tested. Having identified the codes us ed by SKB, several codes were selected for review. Consideration was given to codes used directly in SKB's safety assessment calculations as well as to some of the less visible codes that are important in quantifying the different repository barrier safety functions. SKB's documentation and testing of the following codes were reviewed: COMP23 - a near-field radionuclide transport model developed by SKB for use in safety assessment calculations. FARF31 - a far-field radionuclide transport model developed by SKB for use in safety assessment calculations. PROPER - SKB's harness for executing probabilistic radionuclide transport calculations using COMP23 and FARF31. The integrated analytical radionuclide transport model that SKB has developed to run in parallel with COMP23 and FARF31. CONNECTFLOW - a discrete fracture network model/continuum model developed by Serco Assurance (based on the coupling of NAMMU and NAPSAC), which SKB is using to combine hydrogeological modelling on the site and regional scales in place of the HYDRASTAR code. DarcyTools - a discrete fracture network model coupled to a continuum model, recently developed by SKB for hydrogeological modelling, also in place of HYDRASTAR. ABAQUS - a finite element material model developed by ABAQUS, Inc, which is used by SKB to model repository buffer

  15. The feasibility of Backfilling a Repository of Spent Fuel: An Assessment of Recent Developments by SKB

    International Nuclear Information System (INIS)

    Bennett, David

    2010-12-01

    In the Review Statement and Evaluation of SKB's RDandD programme 2007 (SKI Report 2008:48E), the former Swedish Nuclear Power Inspectorate (SKI) commented that considerable work remained to be done for knowledge of both practical management issues on backfilling and analysis of long-term backfill evolution to reach the same level as for the canister and the buffer. SKI considered that the backfill material had not been thoroughly reported in the RDandD programme. More concrete plans were also needed relating to large-scale demonstration experiments to investigate the performance of the backfill in as realistic conditions as possible. In the spring of 2009, noting that SKB had changed its concept for backfilling several times over the last few years, and after having visited SKB's most recent backfilling trials at Aespoe, both SSM and SSM's expert group BRITE had strong concerns regarding SKB's programme for backfilling the repository tunnels. Although the BRITE expert group has been keeping a watching brief over SKB's development work on backfilling, SSM has not undertaken a systematic assessment of SKB's work in this area since the SR-Can Safety Report was reviewed in 2006. Dr David Bennett, a member and secretary of the BRITE expert group, was asked to do such an assessment. This report describes the assessment results

  16. Review of SKB's Work on Coupled THM Processes Within SR-Can. External review contribution in support of SKI's and SSI's review of SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Rutqvist, Jonny; Chin-Fu Tsang (Lawrence Berkeley National Laboratory, Berkeley, CA (US))

    2008-03-15

    In this report, we scrutinize the work by the Swedish Nuclear Fuel and Waste Management Company (SKB) related to coupled thermal, hydrological and mechanical (THM) processes within the SR-Can project. SR-Can is SKB's preliminary assessment of long-term safety for a KBS-3 nuclear waste repository, and is a preparation stage for the SR-Site assessment, the report that will be used in SKB's application for a final repository. We scrutinize SKB's work related to THM processes through review and detailed analysis, using an independent modeling tool. The modeling tool is applied to analyze coupled THM processes at the two candidate sites, Forsmark and Laxemar, using data defined in SKB's site description models for respective sites. In this report, we first provide a brief overview of SKB's work related to analysis of the evolution of coupled THM processes as presented in SRCan, as well as supporting documents. In this overview we also identify issues and assumptions that we then analyze using our modeling tool. The overview and subsequent independent model analysis addresses issues related to near-field behavior, such as buffer resaturation and the evolution of the excavation-disturbed zone, as well as far-field behavior, such as stress induced changes in hydrologic properties. Based on the review and modeling conducted in this report, we conclude by identifying a number of areas of weaknesses, where we believe further work and clarifications are needed. Some of the most important ones are summarized below: 1) We found that SKB's calculation of peak temperature might not have been conducted for the most conservative case of extreme drying of the buffer under dry rock conditions and an unexpectedly high thermal diffusion coefficient. Our alternative analysis indicates that temperatures close to 100 might be achieved under unfavorable (and perhaps unexpected) conditions in which the buffer is dried to below 20% near the canister. We believe

  17. SKI's and SSI's joint review of SKB's safety assessment report, SR 97. Summary

    International Nuclear Information System (INIS)

    2001-01-01

    The Swedish Nuclear Fuel and Waste Management Co (SKB) has a programme for the siting of a repository for spent nuclear fuel in Swedish bedrock. In 1996, the Swedish Government decided that SKB must perform an assessment of the repository's long-term safety before undertaking the next step of the programme which entails drilling in a minimum of two municipalities (site investigations). SKB has presented such a safety assessment in SR 97 Post-closure Safety (henceforth referred to as SR 97). SR 97 is one of the documents in the comprehensive reporting that SKB must provide when it proposes sites for investigation. The Swedish Nuclear Power Inspectorate (SKI) and the Swedish Radiation Protection Institute (SSI) have evaluated SR 97 in terms of its purposes which are to demonstrate a methodology for safety assessment, to show that Swedish bedrock can provide a safe repository using SKB's method, to provide a basis for specifying the factors that are important for site selection and to derive preliminary requirements on the function of the engineered barriers. The authorities have reached the following conclusions: SR 97 does not indicate any conditions that would mean that geological final disposal in accordance with SKB's method would have significant deficiencies in relation to the safety and radiation protection requirements of the authorities. SR 97 contains the elements required for a comprehensive assessment of safety and radiation protection. SKB's safety assessment methodology has improved within several important areas, such as the documentation of processes and properties that can affect repository performance and the development of models for safety assessment calculations. The methodology used in SR 97 has some deficiencies, for example, the specification of future events to be described in the safety assessment. SR 97 has not, to an adequate extent, dealt with unfavourable conditions that can affect the future safety of a repository. SKB states that the

  18. SKB Annual Report 1994. Including summaries of technical reports issued during 1994

    International Nuclear Information System (INIS)

    1995-05-01

    The report gives an overview of SKB activities in different fields, and a description of R and D on nuclear waste disposal performed during 1994. SKB is in charge of a comprehensive program on geological disposal of nuclear waste. The total cost for R and D 1994 was 186 MSEK of which 59 MSEK were investments in the Aespoe Hard Rock Laboratory. Some of the main areas for SKB research are: Groundwater movements; Bedrock stability; Groundwater chemistry and nuclide migration; Methods and instruments for in situ characterization of crystalline bedrock; Characterization and leaching of spent fuel; Properties of bentonite for buffer, backfilling and sealing; Radionuclide transport in biosphere and dose evaluation; Development of performance and safety assessment methodology and assessment models; Construction of an underground research laboratory. 66 figs, 6 tabs

  19. SKB Annual Report 1994. Including summaries of technical reports issued during 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    The report gives an overview of SKB activities in different fields, and a description of R and D on nuclear waste disposal performed during 1994. SKB is in charge of a comprehensive program on geological disposal of nuclear waste. The total cost for R and D 1994 was 186 MSEK of which 59 MSEK were investments in the Aespoe Hard Rock Laboratory. Some of the main areas for SKB research are: Groundwater movements; Bedrock stability; Groundwater chemistry and nuclide migration; Methods and instruments for in situ characterization of crystalline bedrock; Characterization and leaching of spent fuel; Properties of bentonite for buffer, backfilling and sealing; Radionuclide transport in biosphere and dose evaluation; Development of performance and safety assessment methodology and assessment models; Construction of an underground research laboratory. 66 figs, 6 tabs.

  20. Review of the SKB SR-Can interim report: Evaluation by the Nuclear Inspectorate and the Radiation Protection Authority of SKB's updated methods for safety analysis; Granskning av SKB:s SR-Can interimsrapport: SKI:s och SSI:s bedoemning av SKB:s uppdaterade metoder foer saekerhetsanalys

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-03-01

    In this report the Nuclear Inspectorate and the Radiation Protection Authority comments on the present stage of the safety analysis for an encapsulation plant for spent nuclear fuels and a underground repository. According to the evaluation of the authorities, the SKB methods for safety analysis are well structured and logical and have good potentials as starting points for future safety analyses. However, important parts of the methods need further developments before they can be used for licensing applications. Important progress has been made in several areas compared to the latest safety analysis, SR97, for instance regarding the method for systematic identification and description of all the processes and conditions that need to be considered in the analysis. SKB has also produced improved methods for documentation of different types of expert evaluations and for selection of data for model calculations. Like the international group of experts we see shortcomings in the SKB method for identification and selection of scenarios. The authorities believe that SKB should show, in a systematic and traceable way, that all unfavourable processes, conditions et cetera that have been identified, and could be of importance for the scenario, have been thoroughly evaluated. The authorities see weaknesses in the quality assurance of the interimistic report, that complicates the evaluation of the methods for safety analysis. There are also ambiguities in how SKB plan to optimize/select the best technologies and the role of the safety analysis in this connection. Finally, the authorities give recommendation on how SKB should present the model and methods for analysis that are not yet developed.

  1. SKB annual report 1993. Including summaries of technical reports issued during 1993

    International Nuclear Information System (INIS)

    1994-05-01

    This is the annual report on the activities of the Swedish Nuclear and Waste Management Co., SKB. It contains in part I an overview of SKB activities in different fields. Part II gives a description of the research and development work on nuclear waste disposal performed during 1993. Lectures and publications during 1993 as well as reports issued in the SKB technical series are listed in part III. Part IV contains the summaries of all technical reports issued during 1993. SKB is the owner of CLAB, the Central Facility for Interim Storage of Spent Nuclear Fuel, located at Oskarshamn. CLAB was taken into operation in July 1985 and to the end of 1993 in total 1 885 tonnes of spent fuel (measured as uranium) have been received. Transportation from the nuclear sites to CLAB is made by a special ship, M/S Sigyn. At Forsmark the final repository for Radioactive Waste - SFR - was taken into operation in April 1988. The repository is situated in crystalline rock under the Baltic Sea. At the end of 1993 a total of 13 000 m 3 of waste have been deposited in SFR. SKB is in charge of a comprehensive research and development programme on geological disposal of nuclear waste. Some of the main areas for SKB research are: Groundwater movements; Bedrock stability; Groundwater chemistry and nuclide migration; Methods and instruments for in situ characterization of crystalline bedrock; Characterization and leaching of spent nuclear fuel; Properties of bentonite for buffer, backfilling and sealing; Radionuclide transport in biosphere and dose evaluations; Development of performance and safety assessment methodology and assessment models; Construction of an underground research laboratory

  2. SKI's and SSI's review of SKB's safety report SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Dverstorp, Bjoern; Stroemberg, Bo (and others)

    2008-03-15

    This report summarises SKI's and SSI's joint review of the Swedish Nuclear Fuel and Waste Management Co's (SKB) safety report SR-Can (SKB TR-06-09). SR-Can is the first assessment of post-closure safety for a KBS-3 spent nuclear fuel repository at the candidate sites Forsmark and Laxemar, respectively. The analysis builds on data from the initial stage of SKB's surface-based site investigations and on data from full-scale manufacturing and testing of buffer and copper canisters. SR-Can can be regarded as a preliminary version of the safety report that will be required in connection with SKB's planned licence application for a final repository in late 2009. The main purpose of the authorities' review is to provide feedback to SKB on their safety reporting as part of the pre-licensing consultation process. However, SR-Can is not part of the formal licensing process. In support of the authorities' review three international peer review teams were set up to make independent reviews of SR-Can from three perspectives, namely integration of site data, representation of the engineered barriers and safety assessment methodology, respectively. Further, several external experts and consultants have been engaged to review detailed technical and scientific issues in SR-Can. The municipalities of Oesthammar and Oskarshamn where SKB is conducting site investigations, as well NGOs involved in SKB's programme, have been invited to provide their views on SR-Can as input to the authorities' review. Finally, the authorities themselves, and with the help of consultants, have used independent models to reproduce part of SKB's calculations and to make complementary calculations. All supporting review documents are published in SKI's and SSI's report series. The main findings of the review are: -SKB's safety assessment methodology is overall in accordance with applicable regulations, but part of the methodology needs to be

  3. SKB studies of the periglacial environment - report from field studies in Kangerlussuaq, Greenland 2008 and 2010

    Energy Technology Data Exchange (ETDEWEB)

    Clarhaell, Anders

    2011-03-15

    In order to reduce uncertainties in safety assessments of the planned repository of spent nuclear fuel, SKB identified the need to increase the understanding of glacial and periglacial environments. In collaboration with Posiva OY (Finland) and NWMO (Canada), SKB started the Greenland Analogue Project (GAP) in order to study the effect of climate cooling and glaciation on repository safety. GAP chose an area northeast of Kangerlussuaq, West Greenland, to be studied as a present-day analogue of a future glacial environment in both Scandinavia and Canada. The GAP, planned to run from 2009 until 2012, conducts in situ investigations of some of the parameters and processes needed to achieve a realistic understanding of how an ice sheet may impact a deep repository. In addition, the GAP will provide measurements, observations and data that may significantly improve safety assessments and risk analyses of glaciation scenarios /SKB 2011/. Issues regarding the periglacial surface environment are not included in GAP's primary focus, which has led SKB to initiate parallel activities in the same area. This new project is named The Greenland Analogue Surface Project (GRASP), and will conduct conceptual and numerical modelling of ecosystems, hydrology and near surface hydrogeology. Choosing the same investigation area for the two projects will facilitate common usage of base-line data and logistics in the field. Information from the GRASP will be applied for a better understanding of ecological and hydrological processes in a future periglacial environment in Forsmark. Annual and long-term dynamics of the permafrost are of special interest, as well as the impact of taliks on the transport of matter from the bedrock up towards the surface. This report primarily describes findings from the field season of 2010, but does also report on field work conducted by SKB in 2008. The report provides some background information on the area, describes preliminary results and set-up for

  4. SKB studies of the periglacial environment - report from field studies in Kangerlussuaq, Greenland 2008 and 2010

    International Nuclear Information System (INIS)

    Clarhaell, Anders

    2011-03-01

    In order to reduce uncertainties in safety assessments of the planned repository of spent nuclear fuel, SKB identified the need to increase the understanding of glacial and periglacial environments. In collaboration with Posiva OY (Finland) and NWMO (Canada), SKB started the Greenland Analogue Project (GAP) in order to study the effect of climate cooling and glaciation on repository safety. GAP chose an area northeast of Kangerlussuaq, West Greenland, to be studied as a present-day analogue of a future glacial environment in both Scandinavia and Canada. The GAP, planned to run from 2009 until 2012, conducts in situ investigations of some of the parameters and processes needed to achieve a realistic understanding of how an ice sheet may impact a deep repository. In addition, the GAP will provide measurements, observations and data that may significantly improve safety assessments and risk analyses of glaciation scenarios /SKB 2011/. Issues regarding the periglacial surface environment are not included in GAP's primary focus, which has led SKB to initiate parallel activities in the same area. This new project is named The Greenland Analogue Surface Project (GRASP), and will conduct conceptual and numerical modelling of ecosystems, hydrology and near surface hydrogeology. Choosing the same investigation area for the two projects will facilitate common usage of base-line data and logistics in the field. Information from the GRASP will be applied for a better understanding of ecological and hydrological processes in a future periglacial environment in Forsmark. Annual and long-term dynamics of the permafrost are of special interest, as well as the impact of taliks on the transport of matter from the bedrock up towards the surface. This report primarily describes findings from the field season of 2010, but does also report on field work conducted by SKB in 2008. The report provides some background information on the area, describes preliminary results and set-up for

  5. SKB's program for societal research 2004-2011. An evaluation

    International Nuclear Information System (INIS)

    Soederberg, Olof

    2012-04-01

    This evaluation of the program of societal research that SKB conducted the years 2004-2011 has been performed on behalf of Swedish Nuclear Fuel and Waste Management Company (SKB). The review has focused on answers to a series of questions as follows: General questions - Why was a program started? - What was SKB's purpose with the program? - Does the result mean that the objective has been achieved? - Has the program had effects (positive or negative) that were not anticipated when the purpose was formulated? - Strengths and weaknesses of the program? Questions about the implementation - How did announcement and selection procedures work? - Which forms were used for reporting results from the research projects? Questions about the continued investment in societal research - Are there such needs? - In that case, is it in SKB's interest to contribute financially to such research? - What forms might be appropriate if SKB sees interest to contribute financially to such research?

  6. EnviroAtlas - Candidate Areas for Ecological Restoration for the Conterminous United States

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the candidate areas for ecological restoration, identified as close but geographically disjunct vegetated regions. Ecological...

  7. Review of SKB's reporting of SR 97

    International Nuclear Information System (INIS)

    Tiren, S.A.

    2000-01-01

    The task of the safety assessment is to show 'that the repository has been designed with sufficient margins to be safe in spite of the incomplete knowledge available'. SKB mentions 'confidence in the results' as an important aspect. For the layman, confidence in the information presented is of the greatest importance. This means that the presentation of the safety assessment should be of a high visual standard with respect to descriptions of processes and events. SKB presented the purpose of SR 97 as four points. From a geological-structural geological viewpoint, the following can be mentioned: 1. Methodology for evaluating the geometry of the structural patterns of the bedrock at a depth of 500 m exists in general, but there are also certain deficiencies. Examples include determining the position of the individual structures and obtaining information. The importance of the bedrock is not completely clear. What is related to the rock type and what is related to the geological environment (including the geological evolution)? A clearer and more systematic compilation of data used in the safety assessment is required. 2. Work involving alternative models and evaluations of how well the models explain the collected data would be appropriate. The geological and structural models for a site are included as the base data in calculations and other modelling conducted in connection with the characterization of a site. 3. SR 97 does not provide any detailed information on site investigations. 4. The function of the bedrock as an external barrier is shown. However, to a certain extent, information on how this barrier can be affected by aseismic creep movements along fracture structures and the impact of selective erosion along such structures is lacking. Furthermore, criteria for properties of the rock volumes where deposition drifts are planned should be expanded, such as by determining a minimum width and suitable length-width relations

  8. SKB/TVO ice age scenario

    International Nuclear Information System (INIS)

    Ahlbom, K.; Aeikaes, T.; Ericsson, L.O.

    1991-06-01

    Ice ages have repeatedly occurred throughout geological history, and it is likely that they will also occur in the time-span considered for the disposal of nuclear fuel. Based on the present status of knowledge, this report discusses when future ice ages will occur and the possible changes in the geosphere that might be of importance for repository performance. The report is intended to be used as a basis when developing scenarios for safety analysis of final repository for spent nuclear fuel. Both the ACLIN and Imbrie and Imbrie models suggest stadials (glaciations) at c. 20000, 60000 and 100000 years from now. The ACLIN model also suggests a glaciation period around 5000 years ahead. The next interglacial period will occur at c. 75000 years, according to the Imbrie and Imbrie model, while the ACLIN model suggests that interglacial conditions will not appear until 125000 years form now. Other models strongly support the 60000 year glaciation event. To some extent there is also support for the 20000 and 5000 year events. For the purpose of the SKB/TVO scenario it is suggested that smaller or large glaciations will occur at 5000, 20000 and 60000 years form now. Following the last glaciation, interglacial conditions will prevail at 75000 years. Thus after the first glaciation (5000 years) this is the earliest time when most part of Sweden and Finland will once again be resettled by man. (25 refs.)

  9. Variability and Uncertainties of Key Hydrochemical Parameters for SKB Sites

    Energy Technology Data Exchange (ETDEWEB)

    Bath, Adrian [Intellisci Ltd, Willoughby on the Wolds, Loughborough (United Kingdom); Hermansson, Hans-Peter [Studsvik Nuclear AB, Nykoeping (Sweden)

    2006-12-15

    The work described in this report is a development of SKI's capability for the review and evaluation of data that will constitute part of SKB's case for selection of a suitable site and application to construct a geological repository for spent nuclear fuel. The aim has been to integrate a number of different approaches to interpreting and evaluating hydrochemical data, especially with respect to the parameters that matter most in assessing the suitability of a site and in understanding the geochemistry and groundwater conditions at a site. It has been focused on taking an independent view of overall uncertainties in reported data, taking account of analytical, sampling and other random and systematic sources of error. This evaluation was carried out initially with a compilation and general inspection of data from the Simpevarp, Forsmark and Laxemar sites plus data from older 'historical' boreholes in the Aespoe area. That was followed by a more specific interpretation by means of geochemical calculations which test the robustness of certain parameters, namely pH and redox/Eh. Geochemical model calculations have been carried out with widely available computer software. Data sources and their handling were also considered, especially access to SKB's SICADA database. In preparation for the use of geochemical modelling programs and to establish comparability of model results with those reported by SKB, the underlying thermodynamic databases were compared with each other and with other generally accepted databases. Comparisons of log K data for selected solid phases and solution complexes from the different thermodynamic databases were made. In general, there is a large degree of comparability between the databases, but there are some significant, and in a few cases large, differences. The present situation is however adequate for present purposes. The interpretation of redox equilibria is dependent on identifying the relevant solid phases and

  10. Content Area Teacher Candidates' Self-Efficacy Beliefs of Teaching Writing Online

    Science.gov (United States)

    Saine, Paula; West, Jessica A.

    2017-01-01

    This article focuses on a research study of social studies candidates' self-efficacy beliefs in teaching writing. They coached high school writers online during their content-area literacy course in an effort to assist the high school students in revising their multigenre papers. Over a period of 6 weeks the candidates and the high school students…

  11. Quality Assurance Review of SKB's Copper Corrosion Experiments

    International Nuclear Information System (INIS)

    Baldwin, Tamara D.; Hicks, Timothy W.

    2010-06-01

    SKB is preparing a license application for the construction of a final repository for spent nuclear fuel in Sweden. This application will be supported by the safety assessment SR-Site for the post-closure phase. The assessment of long-term safety is based on a broad range of experimental results from laboratory scale, intermediate scale and up to full scale experiments. It is essential that there is a satisfactory level of assurance that experiments have been carried out with sufficient quality, so that results can be considered to be reliable within the context of their use in safety assessment. The former named authority, SKI, has initiated a series of reviews of SKB's methods of quality assurance and their implementation. This quality assurance review is focused on the work of copper corrosion being conducted in at SKB's Hard Rock Laboratory (HRL) in Aespoe, LOT and Miniature canister (Minican) experiments. In order for the reviewers to get a broad understanding of the issue of copper corrosion both SKB reports as well as the viewpoint of MKG was collected prior to commencement of the actual review task. The purpose of this project is to assess SKB's quality assurance with the view of providing input for the preparation of the SR-Site safety assessment. This has been achieved by examination of the corrosion part of the LOT and Minican experiments using a check list, visits to the relevant facilities, and meetings with contractors and a few members of the SKB staff. The same approach for quality assurance reviews has been used earlier in similar review tasks. During the quality review of the selected projects, several QA- related issues of different degree of severity was noted by the reviewers. The most significant finding was that SKB has chosen to present only selected real-time corrosion monitoring data in TR-09-20. This was surprising and SSM expect that SKB will analyse the reason for this thoroughly. The reviewers also made other observations which can be

  12. Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs.

    Science.gov (United States)

    Gilbreth, M; Yang, P; Bartholomeusz, G; Pimental, R A; Kansra, S; Gadiraju, R; Marcus, S

    1998-12-08

    We previously provided evidence that the protein encoded by the highly conserved skb1 gene is a putative regulator of Shk1, a p21(Cdc42/Rac)-activated kinase (PAK) homolog in the fission yeast Schizosaccharomyces pombe. skb1 null mutants are viable and competent for mating but less elongate than wild-type S. pombe cells, whereas cells that overexpress skb1 are hyperelongated. These phenotypes suggest a possible role for Skb1 as a mitotic inhibitor. Here we show genetic interactions of both skb1 and shk1 with genes encoding key mitotic regulators in S. pombe. Our results indicate that Skb1 negatively regulates mitosis by a mechanism that is independent of the Cdc2-activating phosphatase Cdc25 but that is at least partially dependent on Shk1 and the Cdc2 inhibitory kinase Wee1. We provide biochemical evidence for association of Skb1 and Shk1 with Cdc2 in S. pombe, suggesting that Skb1 and Shk1 inhibit mitosis through interaction with the Cdc2 complex, rather than by an indirect mechanism. These results provide evidence of a previously undescribed role for PAK-related protein kinases as mitotic inhibitors. We also describe the cloning of a human homolog of skb1, SKB1Hs, and show that it can functionally replace skb1 in S. pombe. Thus, the molecular functions of Skb1-related proteins have likely been substantially conserved through evolution.

  13. Review of data types for the SKB site investigation programme

    Energy Technology Data Exchange (ETDEWEB)

    Klos, Richard

    2002-11-01

    SKB is currently undertaking a detailed site investigation programme (SIP) to characterise the geology and surface ecosystems in areas around potential sites for a planned repository for spent nuclear fuel. This report reviews site specific and generic data types needed to characterise biosphere processes relevant to the evaluation of long-term radiological safety in the context of assessments of future impacts arising from the deep geologic disposal of spent nuclear fuel. Focus is on the types of data that make up the different elements of radiological assessment models and how the data used relate to site-specific characteristics. The relevance of the SIP to the development of assessment models for long-term assessment is addressed, including the representation of the geosphere-biosphere interface. Reference to SKB's programme is made in order to determine how well the current programme will meet the needs of assessment models that will be developed and used in the assessment of long-term safety. The review also provides SSI with a basis for the planning of further SSI R and D work. The process, by which site-specific information is converted into a form suitable for use in numerical assessment models, can be quite complex. An overview of assessment model concepts is provided and the links between these and real-word site information considered. Focusing on the needs of assessment models, the review provides a summary of the main types of analyses and site-specific models that are needed for safety evaluations. Review of the SIP indicates that information from the programme feeds into a set of detailed site description models. However there is a gap between the descriptive components and the detailed model descriptions needed to configure numerical assessment models. Details of system evolution are not clearly dealt with in the programme. The SIP focuses on a detailed description of the site the present day. However, radiological impacts are not expected to

  14. Review of Quality Assurance in SKB's Repository Research Experiments

    International Nuclear Information System (INIS)

    Hicks, T.W.

    2007-01-01

    SKB is preparing licence applications for a spent nuclear fuel encapsulation plant and repository which will be supported by the SR-Site safety report. A separate safety report, SR-Can, has been produced by SKB in preparation for the SR-Site report. SKI is in the process of reviewing the SR-Can safety report. In preparation for this review, and with a view to building confidence in SKB's research activities and understanding SKB's handling of data and other information, SKI has examined SKB's application of QA measures in the management and conduct of repository research and development projects that support the SR-Can safety assessment. These preliminary investigations will serve to support the preparation of more detailed quality and technical audits of SKB's repository safety assessment after the submission of a licence application. SKI's approach to this QA review is based on the consideration of quality-affecting aspects of a selection of SKB's research and development activities. As part of this review, SKI identified the need to examine quality-related aspects of some of the many experiments and investigations that form part of SKB's repository research programme. This report presents the findings of such a review, focusing on experiments concerned with the properties and performance of the engineered barrier system. First, in order to establish a broad understanding of QA requirements for repository scientific investigations, QA procedures implemented in the management of research and development activities for the low-level radioactive waste repository near Drigg in the UK and the Waste Isolation Pilot Plant and Yucca Mountain repository projects in the US were studied. The QA procedures for experiments and tests undertaken in these projects were compared with those implemented by SKB. Key findings are: QA programmes have been implemented for each repository development programme in response to regulatory requirements. The need for regular audits of the

  15. The EBS demonstration programme at SKB - some examples

    International Nuclear Information System (INIS)

    Gunnarsson, D.

    2007-01-01

    SKB has been conducting research in the area of nuclear waste disposal in underground environment since the early 1980's. The early tests were conducted in the Stripa mine and in the late 1990's the first full scale tests of EBS installations were carried out in Aspo HRL that was built for the purpose of performing repository research and EBS development. This article focuses on lessons learned concerning the practical aspect of the EBS installation procedures. Specific practical issues as well as how the gained knowledge can be used in the continued. EBS design and optimisation are addressed. The article focuses on the workshop topic 'Confirmation of industrial scale feasibility emplacement of EBS components' but also addresses the topics: - demonstrations of compliance with specifications for emplaced EBS components; - demonstrations/examples of the EBS optimisation process; - identification of remaining key issues and uncertainties to be addressed in the next design optimisation cycle in relation to the scope of the envisaged safety case; - need for (re)assessment of repository and EBS design at later stages of development. (author)

  16. Review of SKB's Safety Assessment SR-Can: Contributions in Support of SKI's and SSI's Review by External Consultants

    International Nuclear Information System (INIS)

    2008-03-01

    The Swedish Nuclear Fuel and Waste Management Co (SKB) plans to submit a license application for the construction of a repository for spent nuclear fuel in Sweden 2010. In support of this application SKB will present a safety report, SR-Site, on the repository's long-term safety and radiological consequences. As a preparation for SR-Site, SKB published the preliminary safety assessment SR-Can in November 2006. The purposes were to document a first evaluation of long-term safety for the two candidate sites at Forsmark and Laxemar and to provide feedback to SKB's future programme of work. An important objective of the authorities' review of SR-Can is to provide guidance to SKB on the complete safety reporting for the license application. The authorities have engaged external experts for independent modelling, analysis and review, with the aim to provide a range of expert opinions related to the sufficiency and appropriateness of various aspects of SR-Can. The conclusions and judgments in this report are those of the authors and may not necessarily coincide with those of SKI and SSI. The authorities own review will be published separately (SKI Report 2008:23, SSI Report 2008:04 E). This report compiles contributions from several specific research projects. The separate reviews cover topics regarding the engineered barrier system, the quality assurance, the climate evolution and its effects, and the ecosystems and environmental impacts. All contributions are in English apart from the review concerning ecosystems and environmental impacts, which is presented in Swedish

  17. Selection of Possible Candidate Area for Nuclear Power Plant in Johor, Malaysia

    International Nuclear Information System (INIS)

    Nor Afifah Basri; Ahmad Termizi Ramli

    2012-01-01

    Nuclear power is considered as one of the best option for future energy development in Malaysia. Since Malaysia has no experience in nuclear energy generation, commissioning the first nuclear power plant needs tremendous effort in various aspects. Site selection is one of important step in nuclear power plant commissioning process. This paper proposes candidate sites for nuclear power plant in Mersing, Kota Tinggi, Muar and Batu Pahat district in Johor, Malaysia. The candidate selection process uses the IAEA document and AELB guideline as main reference, supported by site selection procedure by various countries. MapInfo Professional software was used to simulate the selection process for candidate areas for the nuclear power plant. This paper concluded that Tenggaroh and Jemaluang area are the most suitable area for nuclear power plant facilities in Johor, Malaysia. (Author)

  18. Selection of possible candidate area for nuclear energy facility in Johor, Malaysia

    International Nuclear Information System (INIS)

    Nor Afifah Basri; Ahmad Termizi Ramli

    2012-01-01

    Nuclear power is considered as one of the best option for future energy development in Malaysia. Since Malaysia has no experience in nuclear energy generation, commissioning the first nuclear power plant needs tremendous effort in various aspects. Site selection is one of important step in nuclear power plant commissioning process. This paper proposes candidate sites for nuclear power plant in Mersing, Kota Tinggi, Muar and Batu Pahat district in Johor, Malaysia. The candidate selection process uses the IAEA document and AELB guideline as main reference, supported by site selection procedure by various countries. MapInfo Professional software was used to stimulate the selection process for candidate areas for the nuclear power plant. This paper concluded that Tenggaroh and Jemaluang area are the most suitable area for nuclear power plant facilities in Johor, Malaysia. (Author)

  19. SSI's review of SKB's RD and D programme 2001

    Energy Technology Data Exchange (ETDEWEB)

    Hedberg, Bjoern; Larsson, Carl-Magnus; Wiebert, Anders [and others

    2002-08-01

    In the report SSI's review of SKB's RD and D programme 2001 is presented. In the review SSI comments, among other things, the decision making process, the need for a strategy document, SKB's safety and system analysis and SKB's biosphere studies.

  20. An inventory of continental U.S. terrestrial candidate ecological restoration areas based on landscape context

    Science.gov (United States)

    Landscape context is an important factor in restoration ecology, but the use of landscape context for site prioritization has not been as fully developed. We used morphological image processing to identify candidate ecological restoration areas based on their proximity to existin...

  1. Review of SKB's Quality Assurance Programme

    Energy Technology Data Exchange (ETDEWEB)

    Baldwin, Tamara D.; Hicks, Timothy W. (Galson Sciences LTD, Oakham, Rutland (United Kingdom))

    2009-06-15

    SKB is preparing a license application for the construction of a final repository for spent nuclear fuel in Sweden. This application will be supported by the safety assessment SR-Site for the post-closure phase. The assessment of long-term safety is based on a broad range of experimental results from laboratory scale, intermediate scale and up to full scale experiments. It is essential that there is a satisfactory level of assurance that experiments have been carried of with sufficient quality, so that results can be considered to be reliable within the context of their use in safety assessment. SSM has initiated a series of reviews of SKB's methods of quality assurance and their implementation. This project includes reviews of the quality assurance (QA) procedures and instructions that have been prepared for the SR-Site assessment as well as reviews of QA implementation at the canister and buffer/backfill laboratories in Oskarshamn, Sweden. The purpose of this project is to assess SKB's quality assurance with the view of providing a good basis for subsequent quality reviews in the context of future licensing. This has been achieved by examination of a number of SKB experiments using a check list, visits to the relevant facilities, and meetings with contractors and a few members of the SKB staff. Overall, the reviewed set of QA documents and instructions do provide reasonably comprehensive coverage of quality-affecting issues relating to the SR-Site safety assessment and, if implemented correctly, will generate confidence in the reliability of the safety assessment results. The results show that the efforts involving quality assurance are increasing within the SKB programme and in general appear to be satisfactory for ongoing experiments and measurements. However, progress in development of the QA documents and instructions has been relatively recent and it may be difficult for these to be fully implemented in the short period remaining before the planned

  2. Regional hydrogeological conceptual model of candidate Beishan area for high level radioactive waste disposal repository

    International Nuclear Information System (INIS)

    Wang Hailong; Guo Yonghai

    2014-01-01

    The numerical modeling of groundwater flow is an important aspect of hydrogeological assessment in siting of a high level radioactive waste disposal repository. Hydrogeological conceptual model is the basic and premise of numerical modeling of groundwater flow. Based on the hydrogeological analysis of candidate Beishan area, surface water system was created by using DEM data and the modeling area is determined. Three-dimensional hydrogeological structure model was created through GMS software. On the basis of analysis and description of boundary condition, flow field, groundwater budget and hydrogeological parameters, hydrogeological conceptual model was set up for the Beishan area. (authors)

  3. Review of SKB's interim report of SR-Can: SKI's and SSI's evaluation of SKB's up-dated methodology for safety assessment

    International Nuclear Information System (INIS)

    Dverstorp, Bjoern; Moberg, Leif; Wiebert, Anders; Xu Shulan; Stroemberg, Bo; Kautsky, Fritz; Lilja, Christina; Simic, Eva; Sundstroem, Benny; Toverud, Oeivind

    2005-07-01

    This report presents the findings of a review of the Swedish Nuclear Fuel and Waste Management Co.'s (SKB) interim report of the safety assessment SR-Can (SKB TR 04-11), conducted by the Swedish Radiation Protection Authority (SSI) and the Swedish Nuclear Power Inspectorate (SKI). SKB's interim report describes and exemplifies the safety assessment methodology that SKB plans to use in the oncoming licence applications for an encapsulation plant and a final repository for spent nuclear fuel. The authorities' review takes into account the findings of an international peer review of SKB's interim report. The authorities conclude that SKB has improved its safety assessment methodology in several aspects compared to earlier safety reports. Among other things the authorities commend SKB for giving a comprehensive account of relevant regulations and guidance, and for the systematic approach to identification and documentation of features, events and processes that need to be considered in the safety assessment. However, the authorities also conclude that important parts of SKB's method need to be further developed before they are mature enough to be used as a basis for a license application. The authorities' overall assessment is summarised in chapter 8 of this report

  4. Comments on 'SKB FUD-program 95' focused on canister integrity and corrosion

    International Nuclear Information System (INIS)

    Bowyer, W.H.; Hermansson, H.P.

    1995-03-01

    The work presented in this report is a result of reading the SKB program for R,D and D on safe storage of radioactive wastes. Our work, which is focused on the waste canisters, was commissioned by the Swedish Nuclear Power Inspectorate. We find the program very difficult to follow owing to the lack of detail in chapter seven. In our opinion this will make the work difficult to monitor by SKI or SKB. We also feel that the interpretation of information already available is overoptimistic. As a consequence the difficulties ahead are understated and the programme is converging too quickly. We believe that it should be possible to develop a satisfactory canister for disposal of high level nuclear waste according to the general method proposed by SKB and with the proposed capacity within the timescale of the overall programme. We do not believe, however, that all the difficulties have been recognised. As a consequence of this the results to date are interpreted optimistically. We believe that progress should be subjected to more professional review within SKB and that a higher level of metallurgical support is required. We disagree that suitable full size canisters have been created and that production technology is available for both canisters at full size. We also disagree that the long-time durability is ascertained. I.a. it is easy to find corrosion mechanisms for the canister system that have to be demonstrated not to be harmful. We feel there are many areas which need further evaluation, i.a. effects of non uniform loading and creep, effects of departure from circularity, welding, quality control, effects of radiolysis, corrosion properties, etc. We also feel that insufficient emphasis has been placed on the further development on high power electron beam welding, machining, casting of the insert, testing and overall handling. We consider that more information should be provided on the detail and timing of the development plan for the trial fabrication programme of

  5. Description of background data in the SKB database GEOTAB. Version 2

    International Nuclear Information System (INIS)

    Eriksson, E.; Sehlstedt, S.

    1991-03-01

    During the research and development program performed by SKB for the final disposal of spent nuclear fuel, a large quantity of geoscientific data was collected. Most of this data was stored in a database called Geotab. The data is organized into eight groups as follows: Background information; Geological data; Borehole geophysical measurements; Ground surface geophysical measurements; Hydrogeological and meteorological data; Hydrochemical data; Petrophysical measurements and Tracer tests. Except for the case of borehole geophysical data, ground surface geophysical data and petrophysical data, described in the same report, the data in each group is described in a separate SKB report. The present report describes data within the Background data group. This data provides information on the location of areas studied, borehole positions and also some drilling information. Data is normally collected on forms or as notes and this is then stored into the database. The background data group, called BACKGROUND, is divided into several subgroups: BGAREA area background data; BGDRILL drilling information; BGDRILLP drill penetration data; BGHOLE borehole information; BGTABLES number of rows in a table and BGTOLR data table tolerance. A method consist of one or several data tables. In each chapter a method and its data tables are described. (authors)

  6. SKB's program for societal research 2004-2011. An evaluation; SKB:s program foer samhaellsforskning 2004-2011. En utvaerdering

    Energy Technology Data Exchange (ETDEWEB)

    Soederberg, Olof [Energi- och miljoestrategi O. Soederberg, Solna (Sweden)

    2012-04-15

    This evaluation of the program of societal research that SKB conducted the years 2004-2011 has been performed on behalf of Swedish Nuclear Fuel and Waste Management Company (SKB). The review has focused on answers to a series of questions as follows: General questions - Why was a program started? - What was SKB's purpose with the program? - Does the result mean that the objective has been achieved? - Has the program had effects (positive or negative) that were not anticipated when the purpose was formulated? - Strengths and weaknesses of the program? Questions about the implementation - How did announcement and selection procedures work? - Which forms were used for reporting results from the research projects? Questions about the continued investment in societal research - Are there such needs? - In that case, is it in SKB's interest to contribute financially to such research? - What forms might be appropriate if SKB sees interest to contribute financially to such research?.

  7. 160 Adopting the Euro: A Long Path towards National Consensus within the Euro Area Candidate Countries

    Directory of Open Access Journals (Sweden)

    Adina Criste

    2015-06-01

    Full Text Available The global financial crisis outbreak after 2007 has profoundly changed the course of the history of relations in the world economy, creating a complicated framework of political relations between countries and economic regions. In this context, it is important to depict the economic convergence stage of Euro Area candidate countries and to what extent this crisis has or has not changed the euro adoption objective for these countries. The present paper aimed to shed a light on this issue by analyzing both the state of the convergence process and the public attitude regarding euro adoption in four Euro Area candidate countries which have the same monetary policy strategy (inflation targeting. The research results show the way in which the global financial crisis “deviates” the convergence trajectory of the nominal indicators, but also the political and public sentiment against the euro adoption in the selected countries. The results represent a valuable groundwork for analyzing the way in which National Central Banks candidate to the Eurosystem are implied into the processing for euro adoption during turbulence times

  8. SKB/TVO ice age scenario

    International Nuclear Information System (INIS)

    Ahlbom, K.; Aeikaes, T.; Ericsson, L.

    1991-10-01

    Ice ages have repeatedly occurred throughout geological history, and it is likely that they will also occur in the future. The report discusses the principal processes predicted to occur during future glaciations, and which are likely to be of importance for a repository. The report presents a synthesis of the results in a form of a scenario from two state-of-the-art reports, working meetings and a seminar. Based on the present status of knowledge the climate at Scandinavia will gradually become colder permitting the growth of an ice sheet at 5000 years in the mountainous area of Sweden. After a minor warmer period fully stadial conditions will occur around 20 000 years from now, and after interstadial with dry and cold climate again after 60000 years from now. During the latter glaciation ice thickness at Stockholm-Helsinki region is 2500 m. Interstadial conditions similar to the climate of northern Sweden/Finland will prevail after 75000 years from now. The main changes caused by ice sheet are the downwarping/uplift of the crust and changes in the sea level. In addition, changes in groundwater head and flux are foreseen. As a response from climatic changes tundra and permafrost will appear

  9. SKI's and SSI's joint review of the Swedish Nuclear Fuel and Waste Management Co's (SKB) safety report SR-Can; SKIs och SSIs gemensamma granskning av SKBs saekerhetsrapport SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Dverstorp, Bjoern; Stroemberg, Bo (and others)

    2008-03-15

    This report summarizes SKI's and SSI's joint review of the Swedish Nuclear Fuel and Waste Management Co's (SKB) safety report SR-Can (SKB TR-06-09). SR-Can is the first assessment of post-closure safety for a KBS-3 spent nuclear fuel repository at the candidate sites Forsmark and Laxemar, respectively. The analysis builds on data from the initial stage of SKB's surface-based site investigations and on data from full-scale manufacturing and testing of buffer and copper canisters. SR-Can can be regarded as a preliminary version of the safety report that will be required in connection with SKB's planned license application for a final repository in late 2009. The main purpose of the authorities' review is to provide feedback to SKB on their safety reporting as part of the pre-licensing consultation process. However, SR-Can is not part of the formal licensing process. In support of the authorities' review three international peer review teams were set up to make independent reviews of SR-Can from three perspectives, namely integration of site data, representation of the engineered barriers and safety assessment methodology, respectively. Further, several external experts and consultants have been engaged to review detailed technical and scientific issues in SR-Can. The municipalities of Oesthammar and Oskarshamn where SKB is conducting site investigations, as well NGOs involved in SKB's programme, have been invited to provide their views on SR-Can as input to the authorities' review. Finally, the authorities themselves, and with the help of consultants, have used independent models to reproduce part of SKB's calculations and to make complementary calculations. All supporting review documents are published in SKI's and SSI's report series. The main findings of the review are: SKB's safety assessment methodology is overall in accordance with applicable regulations, but part of the methodology needs to be

  10. Description of hydrogeological data in SKB's database GEOTAB

    International Nuclear Information System (INIS)

    Gentzschein, B.

    1986-12-01

    Since 1977 Swedish Nuclear Fuel and Waste Management Co., SKB has been performing a research and development programme for final disposal and spent nuclear fuel. The purpose of the programme is to acquire knowledge and data of radioactive waste. Measurement for the characterisation of geological, geophysical, hydrogeological and hydrochemical conditions are performed in specific site investigations as well as for geoscientific projects. A database, called GEOTAB, was investigated. It is based on a concept from Mimer Information System, and have been further developed by Ergo-Data. The hardware is a VAX 750 computer located at KRAB (Kraftverksbolagens Redovisningsavdelning AB) in Stockholm. (orig./DG)

  11. Review of SKB's Safety Assessment SR-Can: Contributions in Support of SKI's and SSI's Review by External Consultants

    Energy Technology Data Exchange (ETDEWEB)

    2008-03-15

    The Swedish Nuclear Fuel and Waste Management Co (SKB) plans to submit a license application for the construction of a repository for spent nuclear fuel in Sweden 2010. In support of this application SKB will present a safety report, SR-Site, on the repository's long-term safety and radiological consequences. As a preparation for SR-Site, SKB published the preliminary safety assessment SR-Can in November 2006. The purposes were to document a first evaluation of long-term safety for the two candidate sites at Forsmark and Laxemar and to provide feedback to SKB's future programme of work. An important objective of the authorities' review of SR-Can is to provide guidance to SKB on the complete safety reporting for the license application. The authorities have engaged external experts for independent modelling, analysis and review, with the aim to provide a range of expert opinions related to the sufficiency and appropriateness of various aspects of SR-Can. The conclusions and judgments in this report are those of the authors and may not necessarily coincide with those of SKI and SSI. The authorities own review will be published separately (SKI Report 2008:23, SSI Report 2008:04 E). This report compiles contributions from several specific research projects. The separate reviews cover topics regarding the engineered barrier system, the quality assurance, the climate evolution and its effects, and the ecosystems and environmental impacts. All contributions are in English apart from the review concerning ecosystems and environmental impacts, which is presented in Swedish

  12. SSI's review of the Swedish Nuclear Fuel and Waste Management Co's (SKB) report on large-scale groundwater flow modelling for eastern Smaaland in Sweden (SKB Report 06-64); SSI:s granskning av SKB:s storregionala grundvattenmodellering foer oestra Smaaland (SKB Rapport 06-64)

    Energy Technology Data Exchange (ETDEWEB)

    Dverstorp, Bjorrn

    2007-09-15

    This report presents SSI's review of the Swedish Nuclear Fuel and Waste Management Co's (SKB) report (SKB Report 06-64) on large-scale groundwater flow modelling for eastern Smaaland in Sweden. SSI review is supported by two external review documents (included as appendices). SSI's review is part of a government decided consultation process on SKB's site investigations aimed at finding a suitable site for a spent nuclear fuel repository. SSI considers that SKB has presented a comprehensive study that contributes to the scientific understanding of how different factors influence the regional groundwater flow pattern. However, in SSI's opinion, SKB's evaluation of the modelling results is not complete enough to support SKB's conclusion that super regional flow conditions can be dismissed as a siting factor. SSI therefore recommends SKB to supplement their study in that respect and also to discuss the implications of identified differences in radionuclide travel times and migration distances on the overall assessment of the repository's longterm protective capability. SSI also recommends SKB to revisit some of their modelling assumptions to ensure that the model is set up in a way that does not block out large groundwater circulation cells. SSI's recommendations in this review should be regarded as guidance to SKB. SSI will make a formal assessment of how SKB has taken into account different siting factors, in connection with the review of SKB's license application to be submitted in 2009.

  13. Early developability screen of therapeutic antibody candidates using Taylor dispersion analysis and UV area imaging detection.

    Science.gov (United States)

    Lavoisier, Alexandra; Schlaeppi, Jean-Marc

    2015-01-01

    Therapeutic antibodies represent one of the fastest growing segments in the pharmaceutical market. They are used in a broad range of disease fields, such as autoimmune diseases, cancer, inflammation and infectious diseases. The growth of the segment has necessitated development of new analytical platforms for faster and better antibody selection and characterization. Early quality control and risk assessment of biophysical parameters help prevent failure in later stages of antibody development, and thus can reduce costs and save time. Critical parameters such as aggregation, conformational stability, colloidal stability and hydrophilicity, are measured during the early phase of antibody generation and guide the selection process of the best lead candidates in terms of technical developability. We report on the use of a novel instrument (ActiPix/Viscosizer) for measuring both the hydrodynamic radius and the absolute viscosity of antibodies based on Taylor dispersion analysis and UV area imaging. The looped microcapillary-based method combines low sample consumption, fast throughput and high precision compared to other conventional methods. From a random panel of 130 antibodies in the early selection process, we identified some with large hydrodynamic radius outside the normal distribution and others with non-Gaussian Taylor dispersion profiles. The antibodies with such abnormal properties were confirmed later in the selection process to show poor developability profiles. Moreover, combining these results with those of the viscosity measurements at high antibody concentrations allows screening, with limited amounts of materials, candidates with potential issues in pre-formulation development.

  14. SSI's review of SKB's RDandD programme 2001; SSI's granskning av SKB's FUD-program 2001

    Energy Technology Data Exchange (ETDEWEB)

    Hedberg, B.; Larsson, Carl-Magnus; Wiebert, A.; Dverstorp, B.; Jensen, Mikael; Norden, M.; Loefgren, T.; Brewitz, E.; Lindhe, J.C.; Pensjoe, Aa

    2002-02-01

    In the report SSI's review of SKB's RDandD programme 2001 is presented. In the review SSI comments, among other things, the decision making process, the need of a strategy document, SKB's safety and system analysis and SKB's biosphere studies.

  15. The Swedish Nuclear Power Inspectorate's evaluation of SKB's RD and D Program 98. Summary and conclusions

    International Nuclear Information System (INIS)

    1999-04-01

    Compared to previous programmes, RD and D Programme 98 is focused to a greater extent on method and site selection and on issues relating to the decision-making process. This is natural, since the programme is now approaching the stage where vital decisions will have to be made. The RD and D Programme 98 report is supplemented by a background report 'Detailed Programme for Research and Development 1999-2004' as well as a number of main references 'System Reporting', 'Alternative methods', 'Criteria for Site Evaluation' and the 'North-South/Coast-Interior' report. In addition, a number of references are available in the form of county-specific general siting studies, feasibility studies etc. SKI has distributed RD and D Programme 98 to sixty-three reviewing bodies for comment. The reviewing bodies include universities and institutes of technology, local safety committees, municipalities hosting nuclear facilities and municipalities participating in feasibility studies as well as many authorities. The comments of the reviewing bodies mainly focused on the decision-making process, including issues relating to method selection and site selection and, in particular, on the selection of sites for site investigation. Several reviewing bodies, particularly universities and institutes of technology, have also submitted comments of a more technical-scientific nature. SKI's evaluation has focused on determining whether SKB's programme can be considered to fulfil the requirements stipulated in the Act on Nuclear Activities that such a programme should be able to result in the implementation of solutions for the final disposal of the spent nuclear fuel from the Swedish nuclear power programme. Furthermore, SKI's evaluation has also focused on the conditions that SKI considers should apply to SKB's future work. Specific comments are made for the following areas: Decision-making process, Method selection and system analysis, Siting, Technical development, Safety assessments

  16. SSI's review of the Swedish Nuclear Fuel and Waste Management Co's (SKB) report on large-scale groundwater flow modelling for eastern Smaaland in Sweden (SKB Report 06-64)

    International Nuclear Information System (INIS)

    Dverstorp, Bjorrn

    2007-09-01

    This report presents SSI's review of the Swedish Nuclear Fuel and Waste Management Co's (SKB) report (SKB Report 06-64) on large-scale groundwater flow modelling for eastern Smaaland in Sweden. SSI review is supported by two external review documents (included as appendices). SSI's review is part of a government decided consultation process on SKB's site investigations aimed at finding a suitable site for a spent nuclear fuel repository. SSI considers that SKB has presented a comprehensive study that contributes to the scientific understanding of how different factors influence the regional groundwater flow pattern. However, in SSI's opinion, SKB's evaluation of the modelling results is not complete enough to support SKB's conclusion that super regional flow conditions can be dismissed as a siting factor. SSI therefore recommends SKB to supplement their study in that respect and also to discuss the implications of identified differences in radionuclide travel times and migration distances on the overall assessment of the repository's longterm protective capability. SSI also recommends SKB to revisit some of their modelling assumptions to ensure that the model is set up in a way that does not block out large groundwater circulation cells. SSI's recommendations in this review should be regarded as guidance to SKB. SSI will make a formal assessment of how SKB has taken into account different siting factors, in connection with the review of SKB's license application to be submitted in 2009

  17. Analysis of SKB MiniCan - Experiment 3

    Energy Technology Data Exchange (ETDEWEB)

    Smart, Nick; Rance, Andy; Reddy, Bharti; Fennell, Paul [AMEC (UK); Winsley, Robert [NDA (Country unknown/Code not available)

    2012-11-15

    To ensure the safe encapsulation of spent nuclear fuel rods for geological disposal, SKB of Sweden is planning to use a system that consists of an outer copper canister and a cast iron insert (the KBS-3 concept). In 2007 Serco1 completed the set up of five model canister experiments at SKB's Aespoe laboratory and monitoring has continued since. The original aim of the model canister experiments was to examine how corrosion of the cast iron insert inside a copper canister would evolve with time, if water ingress through a small defect in the copper canister were to occur. Serco arranged manufacture and installation of five miniature copper canisters containing cast iron inserts, with 1 mm defects deliberately machined into the copper shell. The experiments use five small-scale model canisters (300 mm long x 150 mm diameter) that simulate the main features of the SKB canister design (hence the project name, 'MiniCan'). The main aim of the work is to examine how corrosion of the cast iron insert will evolve if a leak is present in the outer copper canister The experiments also included electrochemical equipment to monitor the corrosion behaviour of the model canisters in situ. In 2011 one of the experiments, Experiment 3, was removed f analysis. This report presents details of the procedures that were applied and the findings that were obtained from the analysis that was carried out on Experiment 3. To minimise exposure to air and to keep the contents of the experiment wet until the analysis was carried out, Experiment 3 was extracted from its borehole in August 2011 directly into a transfer tank that was filled with deaerated groundwater and placed in a purpose-built, water-filled and deoxygenated transfer flask. The transfer flask was then transported to the UK for dismantling and examination in a purpose-built anoxic glovebox that contained the appropriate lifting and cutting equipment for handling and sectioning the copper canister and the cast iron

  18. Analysis of SKB MiniCan-Experiment 3

    International Nuclear Information System (INIS)

    Smart, Nick; Rance, Andy; Reddy, Bharti; Fennell, Paul; Winsley, Robert

    2012-11-01

    To ensure the safe encapsulation of spent nuclear fuel rods for geological disposal, SKB of Sweden is planning to use a system that consists of an outer copper canister and a cast iron insert (the KBS-3 concept). In 2007 Serco1 completed the set up of five model canister experiments at SKB's Aespoe laboratory and monitoring has continued since. The original aim of the model canister experiments was to examine how corrosion of the cast iron insert inside a copper canister would evolve with time, if water ingress through a small defect in the copper canister were to occur. Serco arranged manufacture and installation of five miniature copper canisters containing cast iron inserts, with 1 mm defects deliberately machined into the copper shell. The experiments use five small-scale model canisters (300 mm long x 150 mm diameter) that simulate the main features of the SKB canister design (hence the project name, 'MiniCan'). The main aim of the work is to examine how corrosion of the cast iron insert will evolve if a leak is present in the outer copper canister The experiments also included electrochemical equipment to monitor the corrosion behaviour of the model canisters in situ. In 2011 one of the experiments, Experiment 3, was removed f analysis. This report presents details of the procedures that were applied and the findings that were obtained from the analysis that was carried out on Experiment 3. To minimise exposure to air and to keep the contents of the experiment wet until the analysis was carried out, Experiment 3 was extracted from its borehole in August 2011 directly into a transfer tank that was filled with deaerated groundwater and placed in a purpose-built, water-filled and deoxygenated transfer flask. The transfer flask was then transported to the UK for dismantling and examination in a purpose-built anoxic glovebox that contained the appropriate lifting and cutting equipment for handling and sectioning the copper canister and the cast iron insert. The

  19. Development of the KBS-3 method. Survey of SKB's research programs and safety assessments, reviews by Government authorities and SKB's international research cooperation; Utvecklingen av KBS-3-metoden. Genomgaang av forskningsprogram, saekerhetsanalyser, myndighetsgranskningar samt SKB:s internationella forskningssamarbete

    Energy Technology Data Exchange (ETDEWEB)

    2010-11-15

    The purpose of this report is to outline the origin and development over the past 30 years (up to 2009) of the KBS-3 method proposed by the Swedish Nuclear Fuel and Waste Management Co (SKB) for final disposal of spent nuclear fuel. The KBS-3 method is based on three protective barriers. The spent nuclear fuel is encapsulated in impermeable copper canisters. The canisters are placed in crystalline basement rock at a depth of 400-700 metres, embedded in bentonite clay. After disposal the tunnels and rock caverns are sealed. The account does not claim to cover all parts of the extensive technical and scientific research and development work conducted by SKB in form of collecting data, refining methods and increasing process understanding. The report forms part of the background material which SKB has gathered as a basis for future applications regarding permits under the Environmental Code and the Nuclear Activities Act to build and operate facilities for encapsulation and final disposal of spent nuclear fuel. A prominent feature of the industrial development work on the final disposal of spent nuclear fuel has been an openness for a constant input of ideas and opinions from society and public bodies (the Government, national authorities, universities and other institutes of higher education, municipalities and various non-governmental organizations). The presentation sheds light on developments in a number of areas that are of central importance for safety in a KBS-3 repository. In SKB's RDandD Programme 2007, these areas go under the headings rock line, buffer line, canister line, backfilling line and closure line. Furthermore, attention has been given to issues related to the possible retrieval of deposited canisters, variants of KBS-3, deposition technology and safety assessment, as well as a number of interdisciplinary issues. The development of methods for the safety assessment has been an important part of the development of the KBS-3 method. The work

  20. Review of SKB's preliminary safety evaluations for Forsmark and Laxemar; Myndigheternas granskning av SKB:s preliminaera saekerhetsbedoemningar foer Forsmark och Laxemar

    Energy Technology Data Exchange (ETDEWEB)

    Norden, Maria; Wallberg, Petra; Wiebert, Anders; Dverstorp, Bjoern; Shulan Xu (Swedish Radiation Protection Authority, Stockholm (Sweden)); Toverud, Oeivind; Stroemberg, Bo; Kautsky, Fritz; Simic, Eva (Swedish Nuclear Power Inspectorate, Stockholm (Sweden))

    2008-01-15

    This report presents SKI's and SSI's review of SKB's preliminary safety evaluations for Forsmark and Laxemar. The purpose of the review is to assess if the extent of SKB's initial site investigations are sufficient and if they are performed with adequate quality and also if they comprise the data that is needed for future safety analysis. To meet the request from the municipalities where site investigations are performed the authorities have also attempted to elucidate if a site has such obvious weakness that it probably will not comply with authority regulations. The target groups for the review are the municipalities in Oskarshamn and Oesthammar, and SKB

  1. SKI review of SKB research programs 1992. Compilation of scientific reports

    International Nuclear Information System (INIS)

    1993-03-01

    Swedish Nuclear Power Inspectorate (SKI) has reviewed the research programs 1992 of the Swedish Nuclear Fuel and Waste Management Co (SKB). This report presents the examination of the individual programs

  2. SKI's evaluation of SKB's Supplement to RD and D Programme 92

    International Nuclear Information System (INIS)

    1995-05-01

    On December 16, 1993, the Government decided (M93/2525/6), with regard to the 1992 Programme for Research, Development, Demonstration and Other Measures (RD and D Programme 92), compiled by the Swedish Nuclear Fuel and Waste Management Co (SKB) in accordance with Section 12 of the Act on Nuclear Activities, that RD and D Programme 92 should be supplemented by SKB in the manner specified in the decision. On August 19, 1992, SKB submitted the requested supplement to the Swedish Nuclear Power Inspectorate (SKI). SKI has examined the supplement and has requested and obtained comments from a large number of reviewing bodies. SKI hereby submits the documents on the matter along with its own review report. The review report contains an evaluation of SKB's supplement in relation to the government decision and certain recommendations for the structuring of the licensing procedure for planned facilities. These recommendations have taken into account the statements of the reviewing bodies

  3. Developing the Sufficiency Perception Scale in the Area of Accompaniment with Piano for Candidate Music Teachers

    OpenAIRE

    PİJİ, Duygu

    2013-01-01

    The music teacher’s accompanying the songs by piano in music education at schoolappears to be important regarding the development of melody, rhythm and harmony feelingsof the students. The music teacher candidates receive their knowledge and skill in the areaof piano accompaniment through the Accompaniment lesson within the Music TeachingLicense Program. In this research, with the purpose of defining the perception of sufficiencyregarding the accompaniment levels of music teacher candidates a...

  4. The role of international cooperation regarding safety assessment development in the SKB research program

    International Nuclear Information System (INIS)

    Eng, T.; Ahlstrom, P.

    1989-01-01

    Cooperation and exchange of information with organizations in foreign countries regarding nuclear waste management constitutes an important part of the overall research and development activities of SKB. In the safety assessment of a repository for spent nuclear fuel natural phenomena have to be described with different kinds of models based on both general and site specific data. The international cooperation efforts to achieve models and methods for this type of descriptions, and where SKB are largely part, is summarized in this paper

  5. SKB's safety case for a final repository license application

    International Nuclear Information System (INIS)

    Hedin, Allan; Andersson, Johan

    2014-01-01

    The safety assessment SR-Site is a main component in SKB's license application, submitted in March 2011, to construct and operate a final repository for spent nuclear fuel at Forsmark in the municipality of Oesthammar, Sweden. Its role in the application is to demonstrate long-term safety for a repository at Forsmark. The assessment relates to the KBS-3 disposal concept in which copper canisters with a cast iron insert containing spent nuclear fuel are surrounded by bentonite clay and deposited at approximately 500 m depth in saturated, granitic rock. The principal regulatory acceptance criterion, issued by the Swedish Radiation Safety Authority (SSM), requires that the annual risk of harmful effects after closure not exceed 10 -6 for a representative individual in the group exposed to the greatest risk. SSM's regulations also imply that the assessment time for a repository of this type is one million years after closure. The licence applied for is one in a stepwise series of permits, each requiring a safety report. The next step concerns a permit to start excavation of the repository and requires a preliminary safety assessment report (PSAR) covering both operational and post-closure safety. Later steps include permission to commence trial operation, to commence regular operation and to close the final repository. (authors)

  6. Dealing with the current permissibility application for constructing a spent fuel DGR in Sweden. SKB's license applications for a spent fuel repository

    International Nuclear Information System (INIS)

    Olsson, Olle

    2014-01-01

    The nuclear power utilities in Sweden were in 1976 obliged to demonstrate a safe method for final disposal of spent fuel in order to start operation of new reactors. This initiated a comprehensive research, development and demonstration programme and the development of the KBS-method for final disposal. A new Nuclear Activities Act in 1984 gave the reactor owners full technical and financial responsibility for the waste. They gave in turn SKB the responsibility for all nuclear waste management. Reprocessing was no longer required and direct disposal of the spent fuel has, since then, been the main alternative. Alternative methods for final disposal have been evaluated and compared to the KBS-3-method but it has remained the preferred alternative. A comprehensive research, development and demonstration programme to strengthen the scientific basis and to refine the KBS-3-method has been operated by SKB since then. The site selection process for the final repository for spent nuclear fuel was initiated in 1992. The work included general siting studies at the national and the municipal level and in 2002, SKB initiated site investigations for siting of a final repository on two sites: the Simpevarp and Laxemar areas and the Forsmark area. At the same time, the work on preparing license applications to construct and operate an encapsulation plant and a final repository for spent fuel was started. In June 2009, SKB announced Forsmark as the selected site for the final repository. This paper reviews the applicable legislation and describes the license application, the licensing review and the preparations for implementation

  7. Review of Quality Assurance in SKB's Repository Research Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Hicks, T.W. [Galson Sciences Ltd, 5 Grosvenor House, Melton Road, Oakham(United Kingdom)

    2007-01-15

    SKB is preparing licence applications for a spent nuclear fuel encapsulation plant and repository which will be supported by the SR-Site safety report. A separate safety report, SR-Can, has been produced by SKB in preparation for the SR-Site report. SKI is in the process of reviewing the SR-Can safety report. In preparation for this review, and with a view to building confidence in SKB's research activities and understanding SKB's handling of data and other information, SKI has examined SKB's application of QA measures in the management and conduct of repository research and development projects that support the SR-Can safety assessment. These preliminary investigations will serve to support the preparation of more detailed quality and technical audits of SKB's repository safety assessment after the submission of a licence application. SKI's approach to this QA review is based on the consideration of quality-affecting aspects of a selection of SKB's research and development activities. As part of this review, SKI identified the need to examine quality-related aspects of some of the many experiments and investigations that form part of SKB's repository research programme. This report presents the findings of such a review, focusing on experiments concerned with the properties and performance of the engineered barrier system. First, in order to establish a broad understanding of QA requirements for repository scientific investigations, QA procedures implemented in the management of research and development activities for the low-level radioactive waste repository near Drigg in the UK and the Waste Isolation Pilot Plant and Yucca Mountain repository projects in the US were studied. The QA procedures for experiments and tests undertaken in these projects were compared with those implemented by SKB. Key findings are: QA programmes have been implemented for each repository development programme in response to regulatory requirements

  8. Nuclear waste - research and technique development. KASAMS's Review of the Swedish Nuclear Fuel and Waste Management Co's (SKB's) RD and D Programme 2001

    International Nuclear Information System (INIS)

    2002-01-01

    This report is KASAM's review statement to the Government on the Swedish Nuclear Fuel and Waste Management Co's (SKB's) RD and D Programme 2001. KASAM's review was primarily conducted through work by KASAM's members, special adviser, experts and secretary. In KASAM's opinion, the reactor owners, through RD and D Programme 2001, have complied with the requirements of paragraph 12 of the Act on Nuclear Activities. In KASAM's opinion, SKB's research and development programme shows great merit. This applies to both what SKB has done and what it intends to do. The report is well-structured and clear. RD and D Programme 2001 shows that there is still a considerable need for development work in a number of important technical areas. This applies, for example, to the fabrication and sealing of canisters as well as control methods for these activities. Within other areas, for example, geology, chemistry, hydrology, biology and rock mechanics, there is also a great need for further research and development work, and for practical demonstrations of technical applications. In KASAM's opinion, humanities and social science issues, that are of importance for the disposal of nuclear waste, should be accorded greater attention. In Chapter 14, KASAM has presented a proposal for how research in these areas can be organised and financed. KASAM emphasizes that future RD and D programmes should have a broad scientific basis in order to comply with the requirements of the Act on Nuclear Activities regarding comprehensiveness. In their review statements on RD and D Programme 2001, the Swedish Nuclear Power Inspectorate (SKI) and the Swedish Radiation Protection Authority (SSI) have proposed that SKB should be required to present a strategy document which should be kept updated. In KASAM's opinion, such a report of current strategic issues should be made available to the public and other parties concerned. KASAM also believes that such a documentation of strategy issues should be

  9. Workshop on spent fuel performance, radionuclide chemistry and geosphere transport parameters, Lidingoe 2008: Overview and evaluation of recent SKB procedures

    International Nuclear Information System (INIS)

    Meinrath, Guenther; Stenhouse, Mike; Brown, Paul; Ekberg, Christian; Jegou, Christophe; Nitsche, Heino

    2009-08-01

    The safety assessment for disposal of spent nuclear fuel canister in the Swedish bedrock should thoroughly address the time period after a containment failure. Such a failure could be expected as a result of corrosion damage or mechanical failure due to rock movement. This report mainly covers some issues connected to parameters used for radionuclide transport calculations in the areas of spent fuel performance (for fuel in contact with groundwater), radionuclide chemistry, and sorption and geosphere transport parameters. Some examples of topics that are elaborated in some detail include statistical treatment of measurement data (for sorption measurements), handling of uncertainties in speciation calculations, use of triangular distributions in safety assessment and physical processes in connection with spent fuel aging. The results emerged from discussions among international experts at a workshop in May 2008. The purpose of this work is providing an overview of ongoing work within the Swedish Nuclear Fuel and Waste Management Co. (SKB), to provide ideas and suggestions for methodology development and to develop review capability within the SSM. The authors conclude that SKB's treatment of uncertainty in speciation calculations has improved, but that additional efforts in the area of error propagation are recommended. In efforts to condense the scope of utilised thermodynamic databases, the authors recommend that exclusion criteria should be explicitly stated. In the area of sorption, there is a need for more thorough analysis of errors in order to establish uncertainty ranges. The most essential improvements concern dose-limiting nuclides (e.g. Ra-226). Triangular distributions are often featured in SKB safety assessment, but it is not clear that the use of such distributions is based on a firm understanding of its properties. Regarding fuel performance, while safety assessment parameters are supported by measurement data there is still a need for better

  10. Workshop on spent fuel performance, radionuclide chemistry and geosphere transport parameters, Lidingoe 2008: Overview and evaluation of recent SKB procedures

    Energy Technology Data Exchange (ETDEWEB)

    Meinrath, Guenther; Stenhouse, Mike; Brown, Paul; Ekberg, Christian; Jegou, Christophe; Nitsche, Heino

    2009-08-15

    The safety assessment for disposal of spent nuclear fuel canister in the Swedish bedrock should thoroughly address the time period after a containment failure. Such a failure could be expected as a result of corrosion damage or mechanical failure due to rock movement. This report mainly covers some issues connected to parameters used for radionuclide transport calculations in the areas of spent fuel performance (for fuel in contact with groundwater), radionuclide chemistry, and sorption and geosphere transport parameters. Some examples of topics that are elaborated in some detail include statistical treatment of measurement data (for sorption measurements), handling of uncertainties in speciation calculations, use of triangular distributions in safety assessment and physical processes in connection with spent fuel aging. The results emerged from discussions among international experts at a workshop in May 2008. The purpose of this work is providing an overview of ongoing work within the Swedish Nuclear Fuel and Waste Management Co. (SKB), to provide ideas and suggestions for methodology development and to develop review capability within the SSM. The authors conclude that SKB's treatment of uncertainty in speciation calculations has improved, but that additional efforts in the area of error propagation are recommended. In efforts to condense the scope of utilised thermodynamic databases, the authors recommend that exclusion criteria should be explicitly stated. In the area of sorption, there is a need for more thorough analysis of errors in order to establish uncertainty ranges. The most essential improvements concern dose-limiting nuclides (e.g. Ra-226). Triangular distributions are often featured in SKB safety assessment, but it is not clear that the use of such distributions is based on a firm understanding of its properties. Regarding fuel performance, while safety assessment parameters are supported by measurement data there is still a need for better

  11. Review of SKB's interim report of SR-Can: SKI's and SSI's evaluation of SKB's up-dated methodology for safety assessment

    Energy Technology Data Exchange (ETDEWEB)

    Dverstorp, Bjoern; Moberg, Leif; Wiebert, Anders; Xu Shulan [Swedish Radiation Protection Authority, Stockholm (Sweden); Stroemberg, Bo; Kautsky, Fritz; Lilja, Christina; Simic, Eva; Sundstroem, Benny; Toverud, Oeivind [Swedish Nuclear Power Inspectorate, Stockholm (Sweden)

    2005-07-01

    This report presents the findings of a review of the Swedish Nuclear Fuel and Waste Management Co.'s (SKB) interim report of the safety assessment SR-Can (SKB TR 04-11), conducted by the Swedish Radiation Protection Authority (SSI) and the Swedish Nuclear Power Inspectorate (SKI). SKB's interim report describes and exemplifies the safety assessment methodology that SKB plans to use in the oncoming licence applications for an encapsulation plant and a final repository for spent nuclear fuel. The authorities' review takes into account the findings of an international peer review of SKB's interim report. The authorities conclude that SKB has improved its safety assessment methodology in several aspects compared to earlier safety reports. Among other things the authorities commend SKB for giving a comprehensive account of relevant regulations and guidance, and for the systematic approach to identification and documentation of features, events and processes that need to be considered in the safety assessment. However, the authorities also conclude that important parts of SKB's method need to be further developed before they are mature enough to be used as a basis for a license application. The authorities' overall assessment is summarised in chapter 8 of this report.

  12. Comments on 'SKB RD and D-Programme 98'. Focused on canister integrity and corrosion

    International Nuclear Information System (INIS)

    Bowyer, W.H.; Hermansson, H.P.

    1999-04-01

    According to the Act on Nuclear Activities the nuclear utilities are requested to submit a comprehensive programme for research and development every third year, aiming at the safe storage of radioactive waste produced by the nuclear power plants. The latest was published by SKB in September 1998 and is called the 'RDandD Programme 98'. The work presented in the present report was commissioned by SKI and is a result of reading the 'RDandD Programme 98' and related reports with focus on canister production, integrity and corrosion. We find that those parts of the programme often are difficult to follow owing to the lack of detail in the Programme and in one of the supporting reports. In our opinion this will make the work difficult to monitor by SKI and SKB. We also feel that the interpretation of information already available often is overoptimistic. As a consequence the difficulties ahead are understated and the programme is allowed to converge too quickly. We agree that the materials choices for both the inner and outer canisters are appropriate providing they both can be produced commercially and in a satisfactory metallurgical condition, that they can be quality assured and that no further unforeseen difficulties arise. We also agree that alternative technologies merit consideration for production of the outer canister and that alternative joining processes should be studied. We are actually concerned that greater prominence is not given to the alternatives in the programme. We believe that it should be possible to develop a satisfactory canister for disposal of high level nuclear waste according to the general method proposed by SKB and with the proposed capacity within the time-scale of the overall programme. We do not believe, however, that all the difficulties have been recognised. As a consequence of this the results to date are interpreted optimistically. We believe that progress should be subjected to more professional review within SKB and that a higher

  13. Final Disposal of Nuclear Waste. The Swedish National Council for Nuclear Waste's Review of the Swedish Nuclear Fuel and Waste Management Co's (SKB's) RDandD Programme 2007

    International Nuclear Information System (INIS)

    2009-01-01

    and operation and providing guidelines for technology development and research. An important purpose of a systems analysis is to describe and explain which parameters can or should be kept open for modification and improvement, and when decisions must be made to finalize these parameters. The Council finds that systems analysis methodology is valuable as part of a learning process that is controlled by the stakeholders and that involves analysis from new angles and adjustment of the system boundary in a dialogue with the central actors. A coherent and clarifying account should be given of alternative methods for the final disposal of spent nuclear fuel. SKB should present such an account not later than in conjunction with the company's permit applications. The Council believes that SKB should in this account clearly explain its positions on the deep borehole concept. In this context, SKB should also explain its plans for KBS-3 with horizontal deposition. Regarding the Canister: The material and casting process for the nodular iron insert must be optimized so that specified requirements can be met. Otherwise some other type of material must be used. In order to guarantee reliability during canister fabrication and final disposal, quality requirements must be developed with respect to fabrication defects in all parts of the canister, including welds. Continued corrosion studies are required in different areas: accelerated long-term stress corrosion cracking experiments, general corrosion in -chloride- and sulphide-containing water with bentonite, and microbial corrosion, as well as possible corrosion in oxygen-free water. General studies should be conducted regarding what effect existing and altered rock stresses may have on hydraulic conductivity in fractures in different directions and the consequences for the detailed design of the repository. Additional RandD on grouting for sealing of fractures is necessary. A better account should be given of the extent and

  14. Geomorphologic characteristic of low-intermediate level radioactive waste disposal land candidate at Lemahabang area

    International Nuclear Information System (INIS)

    Sucipta

    1998-01-01

    Geomorphological aspect is a factor should be considered on land evaluation for radioactive wastes disposal purpose. The aspect is important because geomorphological factors contribute on hydrological and erosion condition of the land. The objective of the study is to characterize the geomorphological condition of the land, i.e. land form, geomorphological processes, rock type, soil, surface water, ground water, vegetation and land use. The study was conducted by descriptive analyses from literature study and field geomorphological method, with evaluation as well as developed for terrain analyses. The study area can be divided industry for land from units, I.e. tuff undulating unit (land use: plantation), coastal deposits plain unit, silty sand fluvial plain unit (land use: wet rice field) and unconsolidated sand beach deposits plain unit (opened land without vegetation). Hydrologically, the study area can be divided indus tri three small river stream area (RSA). Detailed description of geomorfological condition is showed by table and geomorphological map. (author)

  15. SKB's Project SAFE for the SFR 1 Repository. A Review by Consultants to SKI

    International Nuclear Information System (INIS)

    Chapman, N.A.; Maul, P.R.; Robinson, P.C.; Savage, D.

    2002-06-01

    The SFR 1 repository used for final disposal of low- and intermediate level radioactive waste produced by the Swedish nuclear power programme, industry, medicine and research. In 1992 it was granted a full-scale operating permit following additional reporting on long-term safety aspects by SKB, including the first in-depth safety assessment in 1991. It was stipulated as part of the full-scale licence for SFR 1 that a revised safety assessment should be carried out by SKB at least every ten years during the continued operation of the facility. The first 10-year SKB re-evaluation, called 'Project SAFE', was submitted to the regulators in 2001. The review of Project SAFE presented in this report is the culmination of several years' work with SKI including: 1. The extension and application of SKI's 'systems' approach to set up a description of the SFR 1 repository using Process Influence Diagrams (PIDs). 2. Participation in the development of a flexible Performance Assessment (PA) software tool (the AMBER code) that enables time-dependent analyses to be made of system behaviour. 3. Use of the PID database to explore, from first principles, issues that are likely to be important in the safety performance of SFR 1 and thereby to identify topics to be explored by PA modelling. 4. Peer review of the main SKB Project SAFE supporting documentation to evaluate quality, completeness and the implications of the results. 5. An independent PA exercise, using the AMBER code. 6. A review of an English translation of Section 5 of SKB's Project SAFE Final Safety Report. The present report covers only items 3 to 6, and a separate report provides a more detailed description of item 5. As a result of this review, the key issues that the regulatory authorities will need to address when reviewing SKB's safety case for SFR 1 have been identified as: 1. There is no clear statement of SKB's overall safety concept for SFR 1. It is therefore difficult to judge the results of the PA against

  16. International Collaborations on Engineered Barrier Systems: Brief Overview of SKB-EBS Activities.

    Energy Technology Data Exchange (ETDEWEB)

    Jove-Colon, Carlos F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    Research collaborations with international partners on the behavior and performance of engineered barrier systems (EBS) are an important aspect of the DOE-NE Used Fuel Disposition Campaign strategy in the evaluation of disposal design concepts. These international partnerships are a cost-effective way of engaging in key R&D activities with common goals resulting in effective scientific knowledge exchanges thus enhancing existing and future research programs in the USA. This report provides a brief description of the activities covered by the Swedish Nuclear Fuel and Waste Management Company (SKB) EBS Task Force (TF) (referred hereafter as SKB EBS TF) and potential future directions for engagement of the DOE-NE UFDC program in relevant R&D activities. Emphasis is given to SKB EBS TF activities that are still ongoing and aligned to the UFDC R&D program. This include utilization of data collected in the bentonite rock interaction experiment (BRIE) and data sets from benchmark experiments produced by the chemistry or “C” part of the SKB EBS TF. Potential applications of information generated by this program include comparisons/tests between model and data (e.g., reactive diffusion), development and implementation of coupled-process models (e.g., HM), and code/model benchmarking.

  17. SKB annual report 1991. Including summaries of technical reports issued during 1991

    International Nuclear Information System (INIS)

    1992-05-01

    This is the annual report on the activities of the Swedish Nuclear Fuel and Waste Management Co., SKB. SKB is the owner of CLAB, the central facility for interim storage of spent nuclear fuel, located at Oskarshamn. CLAB was taken into operation in July 1985 and to the end of 1991 in total 1514 tonnes of spent fuel (measured as uranium) have been received. Transportation from the nuclear sites to CLAB is made by a special ship, M/S Sigyn. At Forsmark the final repository for Radioactive Waste (SFR) was taken into operation in April 1988. The repository is situated in crystalline rock under the Baltic Sea. The first construction phase includes rock caverns for 60000 m 3 of waste. A second phase for additional 30000 m 3 is planned to be built and commissioned around the year 2000. At the end of 1991 a total of 7900 m 3 of waste have been deposited in SFR. SKB is in charge of a comprehensive research and development programme on geological disposal of nuclear waste. The total cost for R and D during 1991 was 182.7 MSEK of which 15.9 MSEK came from participants outside Sweden. Geological site-investigations are a substantial part of the programme. SKB is also the managing participant of the international Stripa-project under OECD/NEA. Cost calculations for the total nuclear waste management system, including decommissioning of all reactors, are updated annually. The total cost is estimated to 55 billion SEK. SKB also handles matters pertaining to prospecting and enrichment as well as stockpiling of uranium as strategic reserves for the Swedish nuclear power industry. Consulting service from SKB and associated expert groups are available on a commercial basis. Information activities are an integrated and important part of the Swedish radioactive waste management system. During 1991 successful public information activities have been carried out using mobile exhibitions in a tailor-made trailer and on the SKB ship M/S Sigyn. (au)

  18. Preliminary geological study in kabupaten Pamekasan area to support the selection of candidate site of nuclear desalination plant

    International Nuclear Information System (INIS)

    Ngadenin; Lilik Subiantoro; Kurnia Setiawan Widana

    2014-01-01

    The area around the southern coast Pamekasan is one of the candidates for the alternatives location of nuclear desalination plant site. In 1949 around Sampang Madura ever tectonic earthquake measuring 5 on the Richter scale with its epicenter on land. Tectonic earthquake with epicenter on land is likely related to the presence of active faults on the Madura island. Location prospective nuclear desalination plant site should be away or free of active faults. The study aimed to obtain geological information and find out the characteristics of tectonics including active fault to support site studies of nuclear desalination plant on the island of Madura. The method used is the geological mapping scale, 1 : 50,000. Lithology in the area along the south coast district Pamekasan is alluvium Holocene age and conglomerate units of Pleistocene age. There were no indications of active faults in the region. Candidates site at this location is less attractive in terms of geotechnical foundation as can be ascertained bedrock will be found sufficient in that building construction will require expensive. (author)

  19. Exchange processes at geosphere-biosphere interface. Current SKB approach and example of coupled hydrological-ecological approach

    International Nuclear Information System (INIS)

    Woerman, Anders

    2003-09-01

    The design of the repository for final disposal of spent nuclear fuel proposed by SKB is based on a multi-barrier system, in which the geosphere and biosphere are the utmost barrier surrounding the engineer barriers. This report briefly reviews the current approach taken by SKB to account for hydrological and ecological processes at the geosphere-biosphere interface (GBI) and their future plans in this area. A simple analysis was performed to shift the focus of performance assessment involving geosphere-biosphere interface modelling from the very simplistic assumption that the quaternary sediments are bypassed to one in which a more detailed model for sub-surface flows is included. This study indicated that, for many assumed ecosystem descriptions, the presence of the GBI leads to lower maximum doses to individual humans compared to a case when the GBI is neglected. This effect is due to the additional 'barrier' offered by the GBI. The main exposure pathways were assumed to occur through the food web. However, particularly the leakage on land through the stream-network and lakes can lead to higher doses due to ecosystem interaction with arable land. A scenario that gives particularly long duration of doses occurs due to land rise and with the transformation of the former bay and lake bed sediments into agricultural land. This effect is due to the significant retention or accumulation in aquatic sediment, which causes high activities to build up with time. Particularly, in combination with changing conditions in climate, humans life-style or geographic conditions (land rise, deforestation,etc.) doses to individual humans can be large

  20. Exchange processes at geosphere-biosphere interface. Current SKB approach and example of coupled hydrological-ecological approach

    Energy Technology Data Exchange (ETDEWEB)

    Woerman, Anders [Swedish Univ. of Agricultural Sciences, Uppsala (Sweden). Dept. of Biometry and Technology

    2003-09-01

    The design of the repository for final disposal of spent nuclear fuel proposed by SKB is based on a multi-barrier system, in which the geosphere and biosphere are the utmost barrier surrounding the engineer barriers. This report briefly reviews the current approach taken by SKB to account for hydrological and ecological processes at the geosphere-biosphere interface (GBI) and their future plans in this area. A simple analysis was performed to shift the focus of performance assessment involving geosphere-biosphere interface modelling from the very simplistic assumption that the quaternary sediments are bypassed to one in which a more detailed model for sub-surface flows is included. This study indicated that, for many assumed ecosystem descriptions, the presence of the GBI leads to lower maximum doses to individual humans compared to a case when the GBI is neglected. This effect is due to the additional 'barrier' offered by the GBI. The main exposure pathways were assumed to occur through the food web. However, particularly the leakage on land through the stream-network and lakes can lead to higher doses due to ecosystem interaction with arable land. A scenario that gives particularly long duration of doses occurs due to land rise and with the transformation of the former bay and lake bed sediments into agricultural land. This effect is due to the significant retention or accumulation in aquatic sediment, which causes high activities to build up with time. Particularly, in combination with changing conditions in climate, humans life-style or geographic conditions (land rise, deforestation,etc.) doses to individual humans can be large.

  1. EnviroAtlas - Frequency and Density of Candidate Areas for Ecological Restoration by 12-digit HUC for the Conterminous United States

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the number and density of candidate areas for ecological restoration in each 12-digit HUC. Ecological restoration may become a more...

  2. A malaria diagnostic tool based on computer vision screening and visualization of Plasmodium falciparum candidate areas in digitized blood smears.

    Directory of Open Access Journals (Sweden)

    Nina Linder

    Full Text Available INTRODUCTION: Microscopy is the gold standard for diagnosis of malaria, however, manual evaluation of blood films is highly dependent on skilled personnel in a time-consuming, error-prone and repetitive process. In this study we propose a method using computer vision detection and visualization of only the diagnostically most relevant sample regions in digitized blood smears. METHODS: Giemsa-stained thin blood films with P. falciparum ring-stage trophozoites (n = 27 and uninfected controls (n = 20 were digitally scanned with an oil immersion objective (0.1 µm/pixel to capture approximately 50,000 erythrocytes per sample. Parasite candidate regions were identified based on color and object size, followed by extraction of image features (local binary patterns, local contrast and Scale-invariant feature transform descriptors used as input to a support vector machine classifier. The classifier was trained on digital slides from ten patients and validated on six samples. RESULTS: The diagnostic accuracy was tested on 31 samples (19 infected and 12 controls. From each digitized area of a blood smear, a panel with the 128 most probable parasite candidate regions was generated. Two expert microscopists were asked to visually inspect the panel on a tablet computer and to judge whether the patient was infected with P. falciparum. The method achieved a diagnostic sensitivity and specificity of 95% and 100% as well as 90% and 100% for the two readers respectively using the diagnostic tool. Parasitemia was separately calculated by the automated system and the correlation coefficient between manual and automated parasitemia counts was 0.97. CONCLUSION: We developed a decision support system for detecting malaria parasites using a computer vision algorithm combined with visualization of sample areas with the highest probability of malaria infection. The system provides a novel method for blood smear screening with a significantly reduced need for

  3. SSI's review of SKB's RDandD Program 2007; SSI:s granskning av SKB:s Fud-program 2007

    Energy Technology Data Exchange (ETDEWEB)

    Wiebert, Anders (and others)

    2008-05-15

    In this report, the Swedish Radiation Protection Authority (SSI) provides a review of the Swedish Nuclear Fuel and Waste Managements Company's (SKB) RDandD programme 2007. The report is a statement from SSI in the matter submitted earlier to SKI. In the review, SSI comments SKB's feedback to the continuous research and development program on the basis of the latest carried out safety analysis, SR-Can and the biosphere research. In the statement SSI points to a number of issues that need to be resolved before a licence application is handed in. SSI suggests that the Government asks for complements to the RDandD programme 2007. According to SSI, the programme concerning low and intermediate level waste and decommissioning of the nuclear power plants does not fulfil the requirements established by the Act on Nuclear Activities. Neither does the programme fulfil the expectations set by the Government decision regarding the RDandD programme 2004. SSI suggests that the programme should be complemented

  4. Evaluasi Pelaksanaan Program Kursus Bahasa Inggris Sanggar Kegiatan Belajar (SKB di Propinsi Daerah Istimewa Yogyakarta

    Directory of Open Access Journals (Sweden)

    Nurhaeni Nurhaeni

    2004-01-01

    Full Text Available Penelitian ini bertujuan untuk memperoleh gambaran tentang: (1 relevansi program kursus dengan kebutuhan warga belajar; (2 karakteristik input yang terlibat dalam program; warga belajar, tutor, penyelenggara, program belajar, serta sarana dan prasarana pendukung program; (3 gambaran tentang proses pembelajaran yang mencakup: aktivitas tutor, persiapan mengajar, strategi mengajar, aktivitas warga belajar, pelaksanaan evaluasi kemajuan belajar, (4 manfaat program bagi warga belajar dan kelangsungan program. Sumber data penelitian adalah warga belajar dan pengelola kursus bahasa Inggris yang dilaksanakan oleh SKB Kota Yogyakarta, yang terdiri atas: (1 warga belajar bahasa Inggris sebanyak 15 orang, (2 tutor 2 orang dan (3 3 orang penyelenggara (pamong belajar SKB, (4 Kepala SKB. Data dikumpulkan melalui observasi, wawancara dan dokumentasi dengan model evaluasi CIPP (context, input, process, product. Untuk menganalisis data penelitian ini digunakan metode kualitatif deskriptif berdasarkan kriteria-kriteria yang telah ditetapkan. Hasil penelitian menunjukkan bahwa program kursus bahasa Inggris diselenggarakan dalam rangka memenuhi kebutuhan warga belajar untuk meningkatkan kemampuan mereka dalam berbahasa Inggris. Hasil evaluasi input menunjukkan warga belajar terdiri 15 orang lakd-laki yang sebagian besar dari mereka berusia kurang dari 45 tahun (sasaran usia prioritas. Rata-rata pendidikan warga belajar SLTP dan SLTA. Latar belakang pendidikan tutor dan penyelenggara cukup memenuhi, sarana dan fasilitas pendukung pembelajaran bahasa Inggris masih kurang memadai. Pelaksanaan kegiatan pembelajaran secara rutin berlangsung setiap had selama 10 hari. Tingkat kehadiran warga belajar cukup baik, begitu juga aktivitas warga belajar dalam hal pembelajaran. Tingkat kehadiran dan aktivitas tutor secara keseluruhan dalam kegiatan pembelajaran termasuk baik. Pelaksanaan evaluasi belajar dan tutor maupun pamong belajar SKB dilakukan pada awal program, selama

  5. FISCAL DISCIPLINE AND CONVERGENCE OF THE EURO AREA CANDIDATES. CLOSER TO THE PERFORMERS OR TO THE LAGGARDS?

    Directory of Open Access Journals (Sweden)

    Alexe Ileana

    2012-07-01

    Full Text Available The objective of this paper is to examine how the current financial crisis has affected the fiscal discipline and convergence in the seven Central and Eastern European countries which have not yet joined the Euro Area (EA, namely Bulgaria, the Czech Republic, Hungary, Latvia, Lithuania, Poland and Romania. In the first part, we emphasize the importance of fiscal discipline for the effective functioning of the European Monetary Union (EMU. In the second part, by exploring the current status of the literature in this field, we identify scarce theoretical and empirical research on the non-EA countries’ fiscal discipline and convergence. In the third one, we briefly present the data and methodology used in the paper. We report the fiscal discipline of the non-EA countries by analysing their distance from the Maastricht criteria regarding the budgetary deficit and the public debt as shares of GDP in the fourth part. We also assess the fiscal convergence of the seven candidates for Euro adoption in order to understand whether they add to the strengths or to the weaknesses of the EMU, from a fiscal point of view, by employing two benchmarks: the EA core and the EA periphery. The sovereign debt crisis emphasized the asymmetry between core and periphery countries. It is of major importance to know if the EA candidates will exacerbate the fiscal imbalances by joining the periphery group of countries or by contrast, will promote fiscal discipline and sustainability alongside the core EA member states. The fifth part concludes. The non-EA group of countries has not experienced major fiscal imbalances in the last four years, but the efforts must continue in reducing the budgetary deficits and controlling the public debts. In times of crisis, the EA candidates achieved more convergence with the EA core than with the EA periphery, by reducing the distance from the EA core. This is due to a deterioration in the fiscal performance of the EA core states

  6. Well integrity and workover candidates for existing wells in the Wabamun area CO{sub 2} sequestration project (WASP)

    Energy Technology Data Exchange (ETDEWEB)

    Nygaard, R. [Missouri Univ., of Science and Technology, Rolla, MO (United States); Lavoie, R. [CalPetra Research and Consulting Inc., Calgary, AB (Canada)

    2010-07-01

    More than 100 carbon dioxide (CO{sub 2}) enhanced oil recovery (EOR) projects conducted over the last 3 decades have shown that CO{sub 2} can be successfully transported and injected underground. The CO{sub 2} must be safely stored and prevented from release to the surface or to potable water sources above the injection horizon. This paper presented a decision tree for evaluating leakage potential through existing wells within the Wabamun aquifer which is being considered as a CO{sub 2} storage site. In particular, it reported on a study that examined the feasibility of storing 20 Mt-CO{sub 2} per year for 50 years within 60 km of the Wabamun area CO{sub 2} Sequestration Project (WASP). Several large stationary CO{sub 2} emitters are located in central Alberta, with cumulative annual emissions in the order of 30 Mt CO{sub 2}. An examination of each individual well showed that only 4 out of 27 wells were work over candidates, indicating that well leakage from existing wells in this area is less of a mitigation problem than was first anticipated. Wells in the Nisku formation were found to be more prone to leakage, but the other wells had cement plugs through the cap rock with a cement type to prevent leakage. The study showed that in the case where work overs are needed, they should be performed before the reservoir area is pressurized. The cost and complexity of properly abandoning these wells will be higher at higher pressures and in the presence of CO{sub 2} or hydrogen sulphide. 29 refs., 8 tabs., 9 figs.

  7. Review of SKB's report, SR 97 - Post-closure safety

    International Nuclear Information System (INIS)

    Holmlund, P.

    2000-01-01

    physical basis for the meanings given to these concepts in the report. Although these are only qualitative descriptions of the model designers' assumptions, the results are used quantitatively. Furthermore, the coupling to hydrology includes irrelevant descriptions of how the subglacial drainage in temperate glaciers has a seasonal variation, due to a hydraulic coupling between the surface and the base of the ice. The ice sheets that have covered and will cover Scandinavia are of a cold polar type, which lacks this hydrological coupling between the ice surface and the base, apart from possibly in frontal zones. The report clearly describes the ice as temperate, which must be considered to be an error that has a considerable impact on predictions concerning the subglacial water flow. GCM models have not been applied. The climate is complex and changes in the topography in the form of a growing North American continental ice sheet, change the circulation pattern and, thereby, the distribution of precipitation. Knowledge is available in this area, but this knowledge is not applied in the report. Furthermore, the fact that no sensitivity tests have been conducted of the climate and glacial scenario is surprising

  8. Skb5, an SH3 adaptor protein, regulates Pmk1 MAPK signaling by controlling the intracellular localization of the MAPKKK Mkh1.

    Science.gov (United States)

    Kanda, Yuki; Satoh, Ryosuke; Matsumoto, Saki; Ikeda, Chisato; Inutsuka, Natsumi; Hagihara, Kanako; Matzno, Sumio; Tsujimoto, Sho; Kita, Ayako; Sugiura, Reiko

    2016-08-15

    The mitogen-activated protein kinase (MAPK) cascade is a highly conserved signaling module composed of MAPK kinase kinases (MAPKKKs), MAPK kinases (MAPKK) and MAPKs. The MAPKKK Mkh1 is an initiating kinase in Pmk1 MAPK signaling, which regulates cell integrity in fission yeast (Schizosaccharomyces pombe). Our genetic screen for regulators of Pmk1 signaling identified Shk1 kinase binding protein 5 (Skb5), an SH3-domain-containing adaptor protein. Here, we show that Skb5 serves as an inhibitor of Pmk1 MAPK signaling activation by downregulating Mkh1 localization to cell tips through its interaction with the SH3 domain. Consistent with this, the Mkh1(3PA) mutant protein, with impaired Skb5 binding, remained in the cell tips, even when Skb5 was overproduced. Intriguingly, Skb5 needs Mkh1 to localize to the growing ends as Mkh1 deletion and disruption of Mkh1 binding impairs Skb5 localization. Deletion of Pck2, an upstream activator of Mkh1, impaired the cell tip localization of Mkh1 and Skb5 as well as the Mkh1-Skb5 interaction. Interestingly, both Pck2 and Mkh1 localized to the cell tips at the G1/S phase, which coincided with Pmk1 MAPK activation. Taken together, Mkh1 localization to cell tips is important for transmitting upstream signaling to Pmk1, and Skb5 spatially regulates this process. © 2016. Published by The Company of Biologists Ltd.

  9. SKI`s Evaluation of SKB`s RD and D Programme 95. Summary and Conclusions

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    In SKI`s opinion, the Swedish Nuclear Fuel and Waste Management Co (SKB) has presented a research and development program which fulfills the basic requirements stipulated in the Act on Nuclear Activities. On the whole, the program is appropriate with regard to the development and evaluation of a method for the final disposal of spent nuclear fuel and nuclear waste in the Swedish bedrock. The quality of the supporting research program is high. However, in SKI`s view, the General Siting Study should be supplemented with regard to certain points and the siting factors should be further specified.

  10. Environmental impact statements and public consultations on the repository. An outline of SKB's planning

    International Nuclear Information System (INIS)

    2001-09-01

    In December 2000 SKB selected three locations for further investigations as possible sites for the Swedish repository for spent nuclear fuels, Simpevarp at Oskarshamn, Forsmark at Oesthammar and Tierp. Site investigations will be performed during 5-6 years, and will provide data for a site selection. In the application for the repository commission an environmental impact statement should be included, that has been object for consultations with authorities, local communities, other organizations and the public. These consultations will take place during the whole investigation period, and will give ample possibilities for all parties to give their views and to exert an influence on the EIS

  11. SKI's Evaluation of SKB's RD and D Programme 95. Summary and Conclusions

    International Nuclear Information System (INIS)

    1996-07-01

    In SKI's opinion, the Swedish Nuclear Fuel and Waste Management Co (SKB) has presented a research and development program which fulfills the basic requirements stipulated in the Act on Nuclear Activities. On the whole, the program is appropriate with regard to the development and evaluation of a method for the final disposal of spent nuclear fuel and nuclear waste in the Swedish bedrock. The quality of the supporting research program is high. However, in SKI's view, the General Siting Study should be supplemented with regard to certain points and the siting factors should be further specified

  12. Displacement along extensive deformation zones at the two SKB sites: Forsmark and Laxemar

    International Nuclear Information System (INIS)

    Beckholmen, Monica; Tiren, Sven A.

    2010-12-01

    The Fennoscandian shield, a part of the East European Craton, is distinguished by the exposed bedrock which is mainly composed of Precambrian metamorphic and igneous rocks. Large parts of the ground surface closely coincides with a late Precambrian denudation surface; the sub-Cambrian peneplain. Palaeozoic and younger sediments were deposited on the peneplain but these sediments have been removed from most areas that now form the mainland of Sweden and Finland and there are just a few remnants left. In the Baltic Sea, located in large-scale depressions on the boundary of in the Fennoscandian Shield/ in the East European Craton/, the Precambrian bedrock is still in large parts covered by Palaeozoic sediments. The Palaeozoic sedimentary rocks, as they are well bedded, may form a memory of the late Palaeozoic and younger tectonic events in the underlying basement rocks. Such data are used here to complement the structural observations made at sites located on the mainland, giving information on displacement along faults. Significant for the Baltic Sea are faults oriented in N-S that appear as segments, displaced relative to each other. Other structures are oriented in E-W, NE-SW and NW-SE. The SKB Forsmark site is located in a relatively flat coastal area within the sub-Cambrian peneplain. The sea area at the Forsmark site has a more accentuated relief than what is found on the mainland, for example, a furrow along the western side of the N-S oriented island Graesoe northeast of Forsmark (below 30m b.s.l. and locally more than 50m lower than Graesoe) and the deep between Aaland and Sweden (301m b.s.l.) about 100km east-southeast of Forsmark. In the Forsmark-site area two sets of structures interfere: a WNWESE trending set with relatively straight faults along the north coast of Uppland and a NNW-SSE to N-S trending set, slightly curved, along the (north)east coast of Uppland. The Forsmark site is located in an elevated WNW trending lath-shaped rock block outlined by

  13. The SSI and SKI review of the updated Final Safety Report for SFR 1 issued by SKB. Review report; SSI:s och SKI:s granskning av SKB:s uppdaterade Slutlig Saekerhetsrapport foer SFR 1. Granskningsrapport

    Energy Technology Data Exchange (ETDEWEB)

    Avila, Rodolfo; Jensen, Mikael; Larsson, Carl-Magnus; Lund, Ingemar; Loefgren, Tomas; Moberg, Leif; Norden, Maria; Wiebert, Anders [Swedish Radiation Protection Authority, Stockholm (Sweden); Berglund, Thomas; Dverstorp, Bjoern; Hedberg, Bengt; Kautsky, Fritz; Lilja, Christina; Simic, Eva; Stroemberg, Bo; Sundstroem, Benny; Toverud, Oeivind; Wingefors, Stig; Zika, Helmuth [Swedish Nuclear Power Inspectorate, Stockholm (Sweden)

    2003-11-01

    The repository for operational radioactive wastes in Sweden, SFR1, has been the object for a new safety assessment study by SKB (The Swedish Nuclear Fuel and Waste Management Co.). The findings of the review group will form the basis for decisions by the authorities on the provisions for the future operation of the repository.

  14. Tracer tests - possibilities and limitations. Experience from SKB fieldwork: 1977-2007

    Energy Technology Data Exchange (ETDEWEB)

    Loefgren, Martin; Crawford, James; Elert, Mark (Kemakta Konsult AB, Stockholm (SE))

    2007-09-15

    Tracer tests have played, and still play, a central role in investigations relating to the understanding of radionuclide retention processes in the field. At present there is a debate within the scientific community concerning how, and to what extent, tracer tests can be used to evaluate large-scale and long-term transport and retardation of radionuclides and other solutes of interest for Safety Assessment of repositories for spent nuclear fuel. In this report the SKB fieldwork on tracer tests performed at Swedish sites from 1977 to 2007 is described and discussed. Furthermore, the knowledge and process understanding evolved during the decades of radionuclide transport experiments and modelling within the SKB programme is summarised. One of the main objectives of this report is to discuss what data and knowledge can be extracted from different in situ tests in a robust fashion. Given the level of complexity associated with transport processes that may occur over the timescale of a tracer test, the utility of tracer tests is considered in the context of evidence-based interpretations of data which we characterise in the form of a sequence of questions of increasing complexity. The complexity of this sequence ranges from whether connection can be confirmed between injection and withdrawal points to whether quantitative data can be extrapolated from a tracer test to be subsequently used in Safety Assessment. The main findings of this report are that: Field scale tracer tests can confirm flow connectivity. Field scale tracer tests confirm the existence of retention. Field scale tracer tests alone can only broadly substantiate our process understanding. However, if performing extensive Site Characterisation and integrating the tracer test results with the full range of geoscientific information available, much support can be given to our process understanding. Field scale tracer tests can deliver the product of the material property group MPG and the F-factor, valid

  15. Geosciences research: cooperation with Swedish Nuclear Fuel and Waste Management Co. (SKB)

    International Nuclear Information System (INIS)

    1993-01-01

    PNC has been participating in the research program of the Construction Phase in Aespoe Hard Rock Laboratory project (HRL project), an underground research laboratory project initiated by Swedish Nuclear Fuel and Waste Management Company (SKB), since 1991. The main purpose of participating in the HRL project is to apply site characterization, prediction and validation methodology of geological environment in the project to R and D program on geological disposal in Japan. The outcome from investigations for the 0-700 m section in the access tunnel has been evaluated to compare with predictions on geological-structure. This report gives the summary of R and D program on the HRL project and preliminary results on evaluation of geological-structural predictions for the 0-700 m section in the access tunnel. (author)

  16. Final report of the AECL/SKB Cigar Lake analog study

    International Nuclear Information System (INIS)

    Cramer, J.J.

    1994-07-01

    The Cigar Lake uranium deposit is located in northern Saskatchewan, Canada. The 1.3-billion-year-old deposit is located at a depth of about 450 m below surface in a water-saturated sandstone at the unconformity contact with the high-grade metamorphic rocks of the Canadian Shield. The uranium mineralization, consisting primarily of uraninite (UO 2 ), is surrounded by a clay-rich halo in both sandstone and basement rocks, and remains extremely well preserved and intact. The average grade of the mineralization is ∼ 8 wt.% U; locally grades are as high as ∼ 55 wt.%U. The Cigar lake deposit has many features that parallel those being considered within the Canadian concept for disposal of nuclear fuel waste. Specifically, the deposit provides analog information relevant to the stability of UO 2 fuel waste, the performance of clay-based barriers, radionuclide migration, colloid formation, radiolysis, fission-product geochemistry and general aspects of water-rock interaction. The main geochemical studies on this deposit focus on the evolution of groundwater compositions in the deposit and on their redox chemistry with respect to the uranium, iron and sulphide systems. Since 1984, through cooperation from the owners of the Cigar lake deposit, analog studies have been conducted. AECL, with support from Ontario Hydro under the auspices of the CANDU Owners Group, initiated international participation in 1989 through collaboration with the Swedish Nuclear Fuel and Waste Management Company (SKB) and, more recently, with the Los Alamos National Laboratory (LANL). This report gives the results of the various studies carried out during the 3-year collaboration between AECL and SKB, as well as a summary of the LANL study. It provides detailed information on the generated databases and models, and integrates this information into conclusions for use in safety assessment of the Canadian, Swedish and United States disposal concepts. 15 refs., 25 figs., 55 tabs

  17. Final report of the AECL/SKB Cigar Lake analog study

    International Nuclear Information System (INIS)

    Cramer, J.

    1994-05-01

    The Cigar Lake uranium deposit is located in northern Saskatchewan, Canada. The 1.3-billion-year-old deposit is located at a depth of about 450 m below surface in a water-saturated sandstone at the unconformity contact with the high-grade metamorphic rocks of the Canadian Shield. The Cigar Lake deposit has many features that parallel those being considered within the Canadian concept for disposal of nuclear fuel waste. The study of these natural structures and processes provides valuable insight toward the eventual design and site selection of a nuclear fuel waste repository. The main feature of this analog is the absence of any indication on the surface of the rich uranium ore 450 m below. This indicates that the combination of natural barriers has been effective in isolating the uranium ore from the surface environment. More specifically, the deposit provides analog information relevant to the stability of UO 2 fuel waste, the performance of clay-based barriers, radionuclide migration, colloid formation, radiolysis, fission-product geochemistry and general aspects of water-rock interaction. The main geochemical studies on this deposit focus on the evolution of groundwater compositions in the deposit and on their redox chemistry with respect to the uranium, iron and sulphide systems. Since 1984, through cooperation from the owners of the Cigar Lake deposit, analog studies have been conducted. AECL, with support from Ontario Hydro under the auspices of the CANDU Owners Group, initiated international participation in 1989 through collaboration with the Swedish Nuclear Fuel and Waste Management Company (SKB) and, more recently, with the Los Alamos National Laboratory (LANL). This report gives the results of the various studies carried out during the 3-year collaboration between AECL and SKB, as well as a summery of the LANL study. It provides detailed information on the generated databases and models, and integrates this information into conclusions for use in safety

  18. Assessment of subsidence in karst terranes at selected areas in East Tennessee and comparison with a candidate site at Oak Ridge, Tennessee: Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Newton, J.G.; Tanner, J.M.

    1987-09-01

    Work in the respective areas included assessment of conditions related to sinkhole development. Information collected and assessed involved geology, hydrogeology, land use, lineaments and linear trends, identification of karst features and zones, and inventory of historical sinkhole development and type. Karstification of the candidate, Rhea County, and Morristown study areas, in comparison to other karst areas in Tennessee, can be classified informally as youthful, submature, and mature, respectively. Historical sinkhole development in the more karstified areas is attributed to the greater degree of structural deformation by faulting and fracturing, subsequent solutioning of bedrock, thinness of residuum, and degree of development by man. Sinkhole triggering mechanisms identified are progressive solution of bedrock, water-level fluctuations, piping, and loading. 68 refs., 18 figs., 11 tabs.

  19. The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog.

    Science.gov (United States)

    Gilbreth, M; Yang, P; Wang, D; Frost, J; Polverino, A; Cobb, M H; Marcus, S

    1996-11-26

    The Shk1 protein kinase, a homolog of Saccharomyces cerevisiae Ste20 and mammalian p21Cdc42/Rac-activated kinases, is an essential component of a Ras- and Cdc42-dependent signaling cascade required for cell viability, normal morphology, and mitogen-activated protein kinase-mediated sexual responses in the fission yeast, Schizosaccharomyces pombe. To identify S. pombe proteins that modulate or mediate Shk1 functions, we conducted a two-hybrid screen for Shk1-interacting proteins. One of the genes identified as a result of this screen was skb1. We show that Skb1 interacts with a region of the N-terminal regulatory domain of Shk1 distinct from that to which Cdc42 binds, and that Shk1, Cdc42, and Skb1 are able to form a ternary complex in vivo. S.pombe cells carrying an skb1 null mutation are less elongate in morphology than wild-type cells and exhibit a moderate growth defect. The morphology defect of the skb1 deletion mutant is suppressed by overexpression of Shk1. Overexpression of Skb1 causes wild-type S. pombe cells to become hyperelongated. Additional genetic analyses described herein suggest that Skb1 is a component of the morphology control branch of the Ras signaling cascade in S. pombe and that it positively modulates Shk1 function. Homologs of Skb1 are encoded by open reading frames in the genomes of S. cerevisiae and Caenorhabditis elegans and by an uncharacterized human cDNA sequence. Thus, skb1 may be the first well-characterized member of a highly conserved family of genes encoding potential p21Cdc42/Rac-activated kinase regulators.

  20. The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog

    Science.gov (United States)

    Gilbreth, Mary; Yang, Peirong; Wang, Dan; Frost, Jeff; Polverino, Anthony; Cobb, Melanie H.; Marcus, Stevan

    1996-01-01

    The Shk1 protein kinase, a homolog of Saccharomyces cerevisiae Ste20 and mammalian p21Cdc42/Rac-activated kinases, is an essential component of a Ras- and Cdc42-dependent signaling cascade required for cell viability, normal morphology, and mitogen-activated protein kinase-mediated sexual responses in the fission yeast, Schizosaccharomyces pombe. To identify S. pombe proteins that modulate or mediate Shk1 functions, we conducted a two-hybrid screen for Shk1-interacting proteins. One of the genes identified as a result of this screen was skb1. We show that Skb1 interacts with a region of the N-terminal regulatory domain of Shk1 distinct from that to which Cdc42 binds, and that Shk1, Cdc42, and Skb1 are able to form a ternary complex in vivo. S. pombe cells carrying an skb1 null mutation are less elongate in morphology than wild-type cells and exhibit a moderate growth defect. The morphology defect of the skb1 deletion mutant is suppressed by overexpression of Shk1. Overexpression of Skb1 causes wild-type S. pombe cells to become hyperelongated. Additional genetic analyses described herein suggest that Skb1 is a component of the morphology control branch of the Ras signaling cascade in S. pombe and that it positively modulates Shk1 function. Homologs of Skb1 are encoded by open reading frames in the genomes of S. cerevisiae and Caenorhabditis elegans and by an uncharacterized human cDNA sequence. Thus, skb1 may be the first well-characterized member of a highly conserved family of genes encoding potential p21Cdc42/Rac-activated kinase regulators. PMID:8943016

  1. Geological Mapping and Identification of Active Fault in Site Candidate of Nuclear Power Plant Installation at Ketapang Area and Its Surroundings, Madura

    International Nuclear Information System (INIS)

    Ngadenin; Lilik-Subiantoro; Kurnia-Setiawan-W; Agus-Sutriyono; P Widito

    2004-01-01

    The result of economical study about demand of electric and water supply in Madura Island in 2015 will increase double for domestic or support industry in Madura Island which have to be solved sooner. One way which is considered to solve the problem is Desalination with nuclear electrical plant. In order to support the installation of nuclear Desalination plant, it is needed site free or far from active fault. Active fault is mainly factor to reject the area on site selection process. Aim of the research is to get geological information and identify of active fault in the site candidate of nuclear Desalination plant at Ketapang area and its surrounding by interpretation of air photos and Landsat imagery, geological and structure geological mapping as well as trenching. The lithology of Ketapang and Sokobana site candidate consists of reef and chalky limestone with form of morphology is undulating hills. Structurally, research areas forms a mono cline with east-westerly trending axis, plunging 10 o to E, the direction of strike is W-E, dip 10 o -30 o to the north. This research concludes that an active fault was not found in the area. (author)

  2. SKI's Evaluation of SKB's RD and D Programme 95. Review Report

    International Nuclear Information System (INIS)

    1996-10-01

    SKI (the Swedish Nuclear Power Inspectorate) has sent SKB's (the Swedish Nuclear Fuel and Waste Management Co.) RD and D Programme 95 to sixty authorities and organizations for review. 35 reviewing bodies have replied. In various ways, most of the comments are related to the decision-making process, both with regard to site selection and choice of method and only a small number of reviewing bodies have dealt with the more purely technical issues such as the function of the barriers and the safety assessment methodology. SKI's review of the programme is based on the premises of establishing whether and how the programme can fulfill its actual purpose to identify and implement solutions for the final disposal of the spent nuclear fuel from the Swedish nuclear power plants. SKI's statement to the Government includes a 'Summary and Conclusions' of the 'Review Report'. In (the present) 'Review Report' SKI reviews the programme and deals with comments from the other reviewing bodies. Furthermore, SKI has commissioned a separate report with the 'Comments of the Reviewing Bodies'. 32 refs

  3. SKI`s Evaluation of SKB`s RD and D Programme 95. Review Report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    SKI (the Swedish Nuclear Power Inspectorate) has sent SKB`s (the Swedish Nuclear Fuel and Waste Management Co.) RD and D Programme 95 to sixty authorities and organizations for review. 35 reviewing bodies have replied. In various ways, most of the comments are related to the decision-making process, both with regard to site selection and choice of method and only a small number of reviewing bodies have dealt with the more purely technical issues such as the function of the barriers and the safety assessment methodology. SKI`s review of the programme is based on the premises of establishing whether and how the programme can fulfill its actual purpose to identify and implement solutions for the final disposal of the spent nuclear fuel from the Swedish nuclear power plants. SKI`s statement to the Government includes a `Summary and Conclusions` of the `Review Report`. In (the present) `Review Report` SKI reviews the programme and deals with comments from the other reviewing bodies. Furthermore, SKI has commissioned a separate report with the `Comments of the Reviewing Bodies`. 32 refs.

  4. Colloids or artefacts? A TVO/SKB cooperation project in Olkiluoto, Finland

    International Nuclear Information System (INIS)

    Laaksoharju, M.; Vuorinen, U.; Snellman, M.; Helenius, J.; Allard, B.; Pettersson, C.; Hinkkanen, H.

    1993-12-01

    TVO (Teollisuuden Voima Oy, Finland) initiated a co-operative task with SKB (Swedish Nuclear Fuel and Waste Management Co.) to critically evaluate colloid sampling methods at the test site in Olkiluoto, SW Finland. Three different colloid sampling methods were compared when sampling borehole OL-KR1 at 613-618 m depth. One possible way to make a conservative in-situ colloid estimation is to omit the contribution from calcite precipitation which is considered to be the main artefact. When this is made the inorganic colloid content (size 1-1000 nm) in Olkiluoto is 184 ±177 ppb consisting of clay minerals, silica, pyrite, goethite and magnesium oxide; the concentration of organic substances are around 100 ppb. The in-situ colloid concentration seems to be low which is in good agreement with experiences from years of sampling in similar environment and depths. The exercise shows the many difficulties encountered when sampling colloids. Small error in the planning, pump rate selection, a lack of precautionary measures, artefact sensitivity of the method etc have a tendency to affect significantly the results on the measured ppb colliod level

  5. Opinions on SKB's Safety Assessments SR 97 and SFL 3-5. A Review by SKI Consultants

    International Nuclear Information System (INIS)

    2000-12-01

    The Swedish Nuclear Fuel and Waste Management Co. (SKB) has presented their safety assessment 'Deep repository for spent nuclear fuel, SR 97 - Post-closure safety'. SKB's report is part of the documentation that has been required by the Government before the start of site investigations. The Swedish Nuclear Power Inspectorate (SKI) is reviewing SR 97 according to earlier Government decisions. In its review work SKI has asked several consultants, that recently have been performing research work for SKI, to give their opinions on SR 97. SKI and the Swedish Radiation Protection Institute (SSI) have used these reports from the consultants as one complementary basis for the formulation of the SKI/SSI review report. This is a compilation of the reports from the different consultants, and therefore the different contributions vary in length, style and language. Included are also two consultant reports, giving comments on SKB's preliminary safety assessment for SFL 3-5 (deep repository for long-lived low- and intermediate-level waste). The 17 contributions have all been separately indexed

  6. Opinions on SKB's Safety Assessments SR 97 and SFL 3-5. A Review by SKI Consultants

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-12-01

    The Swedish Nuclear Fuel and Waste Management Co. (SKB) has presented their safety assessment 'Deep repository for spent nuclear fuel, SR 97 - Post-closure safety'. SKB's report is part of the documentation that has been required by the Government before the start of site investigations. The Swedish Nuclear Power Inspectorate (SKI) is reviewing SR 97 according to earlier Government decisions. In its review work SKI has asked several consultants, that recently have been performing research work for SKI, to give their opinions on SR 97. SKI and the Swedish Radiation Protection Institute (SSI) have used these reports from the consultants as one complementary basis for the formulation of the SKI/SSI review report. This is a compilation of the reports from the different consultants, and therefore the different contributions vary in length, style and language. Included are also two consultant reports, giving comments on SKB's preliminary safety assessment for SFL 3-5 (deep repository for long-lived low- and intermediate-level waste). The 17 contributions have all been separately indexed.

  7. Prey Acceptability and Preference of Oenopia conglobata (Coleoptera: Coccinellidae, a Candidate for Biological Control in Urban Green Areas

    Directory of Open Access Journals (Sweden)

    Belén Lumbierres

    2018-01-01

    Full Text Available Oenopia conglobata is one of the most common ladybird species in urban green areas of the Mediterranean region. We have obtained data about its prey acceptability and prey preferences. In a laboratory experiment, we investigated the acceptability of seven aphid and one psyllid species as prey for this coccinellid: the aphids Chaitophorus populeti, Aphis gossypii, Aphis craccivora Monelliopsis caryae, Eucallipterus tiliae, Aphis nerii (on white poplar, pomegranate, false acacia, black walnut, lime, and oleander, respectively, and the psyllid Acizzia jamatonica on Persian silk tree. These species are abundant in urban green areas in the Mediterranean region. In addition, we tested the acceptability of Rhopalosiphum padi on barley, an aphid species easily reared in the laboratory. We also tested preferences of the predator in cafeteria experiments with three aphid species and one aphid and the psyllid. Adults and larvae of the coccinellid accepted all of the preys offered, except A. nerii, with a clear preference for M. caryae. The predator also showed preference for M. caryae when it was offered in a cafeteria experiment with other aphid species or with the psyllid. The aphid R. padi obtained a good acceptability and could be used for rearing O. conglobata in the laboratory.

  8. Prey Acceptability and Preference of Oenopia conglobata (Coleoptera: Coccinellidae), a Candidate for Biological Control in Urban Green Areas.

    Science.gov (United States)

    Lumbierres, Belén; Madeira, Filipe; Pons, Xavier

    2018-01-12

    Oenopia conglobata is one of the most common ladybird species in urban green areas of the Mediterranean region. We have obtained data about its prey acceptability and prey preferences. In a laboratory experiment, we investigated the acceptability of seven aphid and one psyllid species as prey for this coccinellid: the aphids Chaitophorus populeti, Aphis gossypii , Aphis craccivora Monelliopsis caryae , Eucallipterus tiliae , Aphis nerii (on white poplar, pomegranate, false acacia, black walnut, lime, and oleander, respectively), and the psyllid Acizzia jamatonica on Persian silk tree. These species are abundant in urban green areas in the Mediterranean region. In addition, we tested the acceptability of Rhopalosiphum padi on barley, an aphid species easily reared in the laboratory. We also tested preferences of the predator in cafeteria experiments with three aphid species and one aphid and the psyllid. Adults and larvae of the coccinellid accepted all of the preys offered, except A. nerii , with a clear preference for M. caryae . The predator also showed preference for M. caryae when it was offered in a cafeteria experiment with other aphid species or with the psyllid. The aphid R. padi obtained a good acceptability and could be used for rearing O. conglobata in the laboratory.

  9. The Candidate

    OpenAIRE

    Osborn, John C

    2013-01-01

    ABSTRACT   The Candidate is an attempt to marry elements of journalism and gaming into a format that both entertains and educates the player. The Google-AP Scholarship, a new scholarship award that is given to several journalists a year to work on projects at the threshold of technology and journalism, funded the project. The objective in this prototype version of the game is to put the player in the shoes of a congressional candidate during an off-year election, specificall...

  10. SSI's Review of the RDandD Program 2004 of the Swedish Nuclear Fuel and Waste Management Co; SSI:s granskning av SKB:s Fud-program 2004

    Energy Technology Data Exchange (ETDEWEB)

    Larsson, Carl-Magnus; Hedberg, Bjoern; Wiebert, Anders [and others

    2005-06-01

    In this report the Swedish Radiation Protection Authority's (SSI) review of the Swedish Nuclear Fuel and Waste Management Company's (SKB) RDandD programme 2004 is presented. In the review SSI comments, among other things, SKB's plan of action and future direction of SKB's RDandD programme, need for different types of consultations, plans for demonstration of canister deposition and long term experiments, and strategies for dismantling of nuclear facilities.

  11. Review of results from SKB R and D on grouting technology for sealing the rock, years 1996-2000

    International Nuclear Information System (INIS)

    Boden, A.; Eklund, D.; Eriksson, Magnus; Lagerblad, B.; Lindblom, U.

    2001-05-01

    In order identify the current state of the art and developments needs, SKB assembled a group of experts from universities and other research organisations. Internal plans were written for the subprojects 'Characterisation of rock for grouting purposes', 'Mechanisms that control the spreading of grout in jointed rock' and 'Cement based grouting material'. Later internal plans for the subprojects 'Demands on grouting' and 'Stabilising and sealing effect of pre-grouting' were written. The aims, which were set for the different subprojects, were in short, to summarise the technological advances, establish a method for rock characterisation from a grouting point of view, develop conceptual and numerical models for simulation of the grouting course, characterise grout in a relevant way, develop understanding and theoretical know-how of durability and chemical influence, identify and develop a number of grouting materials for different situations, develop a specification of requirements for grouting and to verify the theories in laboratory. In the subproject 'Demands on grouting' a literature review was carried out. One important conclusion from the study is that the concept is not very well dealt with in the literature. SKB are currently investigating the prerequisites for the construction of the deep repository. One part of that work is to further specify demands on maximum allowed volume of leakage water for the repository as a whole and also for each part of the deep repository. In the subproject 'Characterisation of rock for grouting purposes', the possibilities of using hydraulic tests for predictions and design have been studied. The idea of this study was to investigate correspondences and deviations to increase the understanding of what is measured in a water-loss measurement. One can draw the conclusion that hydraulic tests are useful when describing the fracture geometry. Numerical modelling and experiments indicate that the specific capacity, Q/Δh, (flow

  12. Lessons learnt to keep Europe polio-free: a review of outbreaks in the European Union, European Economic Area, and candidate countries, 1973 to 2013.

    Science.gov (United States)

    Derrough, Tarik; Salekeen, Alexandra

    2016-04-21

    Between 1973 and 2013, 12 outbreaks of paralytic poliomyelitis with a cumulative total of 660 cases were reported in the European Union, European Economic Area and candidate countries. Outbreaks lasted seven to 90 weeks (median: 24 weeks) and were identified through the diagnosis of cases of acute flaccid paralysis, for which infection with wild poliovirus was subsequently identified. In two countries, environmental surveillance was in place before the outbreaks, but did not detect any wild strain before the occurrence of clinical cases. This surveillance nonetheless provided useful information to monitor the outbreaks and their geographical spread. Outbreaks were predominantly caused by poliovirus type 1 and typically involved unvaccinated or inadequately vaccinated groups within highly immunised communities. Oral polio vaccine was primarily used to respond to the outbreaks with catch-up campaigns implemented either nationwide or in restricted geographical areas or age groups. The introduction of supplementary immunisation contained the outbreaks. In 2002, the European region of the World Health Organization was declared polio-free and it has maintained this status since. However, as long as there are non-vaccinated or under-vaccinated groups in European countries and poliomyelitis is not eradicated, countries remain continuously at risk of reintroduction and establishment of the virus. Continued efforts to reach these groups are needed in order to ensure a uniform and high vaccination coverage.

  13. Mechanical failure of SKB spent fuel disposal canisters. Mathematical modelling and scoping calculations

    Energy Technology Data Exchange (ETDEWEB)

    Takase, Hiroyasu; Benbow, S.; Grindrod, P. [QuantiSci Ltd., Melton Mowbray (United Kingdom)

    1998-10-01

    According to the current design of SKB, a copper overpack with a cast steel inner component will be used as the disposal canister for spent nuclear fuel. A recent study considered the case of a breach in the copper overpack, through which groundwater could enter the canister. It has pointed out that hydrogen gas generated by an anaerobic corrosion could cushion the system and reduce or eventually stop further infiltration of water into the breached canister, and thence the spent fuel. One potential pitfall in this previous study lies in the fact that it did not consider any processes which might violate the following assumptions which are essential for the gas 'cushioning': 1. Hydrogen gas accumulated in the annular gap in the canister forms a free gas phase which is stable indefinitely into future; 2. Elevated gas pressure in the canister prevents further supply of groundwater except for diffusion of vapour. In the current study we developed a set of mathematical models for the above problem and applied it to carry out an independent assessment of the long-term behaviour of the canister. A key aim in this study was to clarify whether there are any alternative processes which may affect the result obtained by the previous study by violating one of the assumptions listed above. For this purpose, a scenario development exercise was conducted. The result supported the concept described in the previous study. One exception is that possible intrusion of bentonite gel followed by its desaturation could leave paths both for the gas and water simultaneously without forming a gas cushion. This is summarised in the first part of the report. In the second part, development of mathematical models and their applications are described. The key results are: 1. The model describing behaviour of gas and pore water in the canister and the buffer material reproduced the main results of the previous study; 2. The model considering intrusion of the bentonite gel pointed out

  14. Mechanical failure of SKB spent fuel disposal canisters. Mathematical modelling and scoping calculations

    International Nuclear Information System (INIS)

    Takase, Hiroyasu; Benbow, S.; Grindrod, P.

    1998-10-01

    According to the current design of SKB, a copper overpack with a cast steel inner component will be used as the disposal canister for spent nuclear fuel. A recent study considered the case of a breach in the copper overpack, through which groundwater could enter the canister. It has pointed out that hydrogen gas generated by an anaerobic corrosion could cushion the system and reduce or eventually stop further infiltration of water into the breached canister, and thence the spent fuel. One potential pitfall in this previous study lies in the fact that it did not consider any processes which might violate the following assumptions which are essential for the gas 'cushioning': 1. Hydrogen gas accumulated in the annular gap in the canister forms a free gas phase which is stable indefinitely into future; 2. Elevated gas pressure in the canister prevents further supply of groundwater except for diffusion of vapour. In the current study we developed a set of mathematical models for the above problem and applied it to carry out an independent assessment of the long-term behaviour of the canister. A key aim in this study was to clarify whether there are any alternative processes which may affect the result obtained by the previous study by violating one of the assumptions listed above. For this purpose, a scenario development exercise was conducted. The result supported the concept described in the previous study. One exception is that possible intrusion of bentonite gel followed by its desaturation could leave paths both for the gas and water simultaneously without forming a gas cushion. This is summarised in the first part of the report. In the second part, development of mathematical models and their applications are described. The key results are: 1. The model describing behaviour of gas and pore water in the canister and the buffer material reproduced the main results of the previous study; 2. The model considering intrusion of the bentonite gel pointed out possibility

  15. Evaluation and modelling of SWIW tests performed within the SKB site characterisation programme

    International Nuclear Information System (INIS)

    Nordqvist, Rune

    2008-08-01

    In this report, a comprehensive overview of SWIW (Single Well Injection-Withdrawal) tests carried out within the SKB site investigations at Oskarshamn and Forsmark is presented. The purpose of this study is to make a general review and a comparison of performed SWIW tests within the site investigation programmes at the two sites. The study summarises experimental conditions for each test and discusses factors that may influence the experimental results and evaluation of the tests. Further, an extended model evaluation is carried out using a one- dimensional radial flow and transport model with matrix diffusion and matrix sorption. The intended outcome is an improved understanding of various mechanisms that may influence the SWIW test results and also to improve interpretation of the tests. Six SWIW test at each site have been carried out, generally resulting in high-quality and well documented experimental data with high tracer recovery. The tests have been performed in surface boreholes at repository depth, ranging approximately between 300 to 700 m borehole lengths. In all of the tests, a non-sorbing tracer (Uranine) and one or two sorbing tracers (cesium and rubidium) have been used simultaneously. A general result is that all of the tests demonstrate a very clear and relatively large retardation effect for the sorbing tracers. Basic initial modelling of the SWIW tests data, using a one-dimensional radial flow model with advection and dispersion, generally resulted in relatively good agreement between model and experimental data. However, a consistent feature of the initial modelling was a discrepancy between model and experimental data in the later parts of the recovery tracer breakthrough curve. It was concluded that this likely was caused by processes occurring in the tested rock formation and therefore an extended model evaluation (presented in this report) including matrix diffusion was carried out on all of the performed tests. Evaluated retardation

  16. Stimulering van ziektewering in de bodem door toevoegen van reststromen : 'Cash from trash' : eindrapport SKB-Duurzame ontwikkeling ondergrond project 2031

    NARCIS (Netherlands)

    Postma, J.; Schilder, M.T.; Hanse, B.; Hendrickx, W.; Venhuizen, A.

    2013-01-01

    Dit rapport bevat de resultaten van twee jaar onderzoek naar praktijktoepasbare methoden om de ziektewering in de bodem tegen Rhizoctonia solani, een belangrijke gewasbelager, te verhogen. Het huidige SKB project is gestart om goedkope effectieve reststoffen te identificeren en te zoeken naar een

  17. SR 97 - Waste, repository design and sites. Background report to SR 97 SKB

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-10-01

    the site-specific configuration of the repositories in Aberg, Beberg and Ceberg. However, other sites of the repository for other long-lived waste are possible. The category of other long-lived waste also includes core components and reactor internals that have been situated close to the fuel core in the power reactors. Besides the waste from research and power reactors, the repository for other long-lived waste will also receive short-lived low- and intermediate-level waste that is produced after the closure of SFR 1 in Forsmark. SKB investigates the long-term safety of the repository for other long-lived waste in a separate safety report. A brief description of the waste intended to be disposed of in a deep repository is given in Chapter 2. Spent fuel equivalent to approximately 4,500 canisters is generated during operation of the nuclear reactors for 40 years. The BWR fuel SVEA 96 has been chosen as the reference fuel. The activity level in the reference fuel has been calculated for a period of 40 years after discharge from the reactor. The calculations include fission products, actinides and activation products. Chapter 3 follows with a description of the conceptual design of the repository system based on the KBS-3 method for deep geological disposal in Swedish crystalline bedrock. The engineered barriers consist chiefly of copper canisters with an insert of cast iron, buffer and tunnel backfill plus plugs. An account of the geoscientific properties of the different repository sites is given in Chapter 4. The account includes completed geoscientific investigations, geological/structural descriptions on a regional and local scale, descriptions of rock mechanics, hydrogeology and groundwater chemistry, and descriptions of the thermal properties of the different sites. Site-specific adaptation of the repositories is dealt with in the last chapter. The main factors that influence the layout of the repositories are rock stresses and the direction and properties of

  18. Joint SKI and SSI review of SKB preliminary safety assessment of repository for long-lived low- and intermediate-level waste. Review report

    International Nuclear Information System (INIS)

    2001-03-01

    SKI and SSI find that SKB's first proper safety assessment of the SFL 3-5 repositories provides a valuable springboard for continued efforts in this field. Even though the safety assessment is relatively limited in scope, it has numerous merits. The specific problems associated with the chosen repository concept for SFL 3-5 are discussed in a generally transparent manner. On the other hand, the authorities consider that SKB have only partly achieved the expressed goal of studying the significance of the current repository design and the choice of site. The greatest deficiency consists in that neither internal disturbances (such as considerable cracking or degradation of concrete structures) nor external disturbances (such as the effects of climate changes and glaciation) have been addressed in a thorough manner. A coherent report justifying the design choice from a long-term safety perspective is, in large part, not found here. SKI and SSI recommend that SKB provide a comparison with other possible SFL 3-5 repository designs. Depending upon, among other factors, what geospheric and biospheric conditions are assumed, SKB have shown that the calculated dose values could be relatively high for certain cases. More realistic assessments would be needed to draw reasonable comparisons between different sites, and to evaluate the importance of different nuclides in different contexts. Our review of SKBs preliminary safety assessment indicates that a great deal of research and development work remains to be done before the level of knowledge in this field is comparable with that associated with the final repository for spent fuel. This is reflected with unanimity in the international expert committee's review, and in the consultants' reviews. SKI and SSI wish to point out in particular the fact that comparison with SFR is of limited value, since the safety associated with SFL 3- 5 must be assessed on a much longer time scale. SKI and SSI find it remarkable that SKB have

  19. A Review of Models for Dose Assessment Employed by SKB in the Renewed Safety Assessment for SFR 1

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, George [Imperial College of Science Technology and Medicine (United Kingdom)

    2002-09-01

    This document provides a critical review, on behalf of SSI, of the models employed by the Swedish Nuclear Fuel and Waste Management Co (SKB) for dose assessment in the renewed safety assessment for the final repository for radioactive operational waste (SFR 1) in Forsmark, Sweden. The main objective of the review is to examine the models used by SKB for radiological dose assessment in a series of evolving biotopes in the vicinity of the Forsmark repository within a time frame beginning in 3000 AD and extending beyond 7500 AD. Five biosphere models (for coasts, lakes, agriculture, mires and wells) are described in Report TR-01-04. The principal consideration of the review is to determine whether these models are fit for the purpose of dose evaluation over the time frames involved and in the evolving sequence of biotopes specified. As well as providing general observations and comments on the modelling approach taken, six specific questions are addressed, as follows. Are the assumptions underlying the models justifiable? Are all reasonably foreseeable environmental processes considered? Has parameter uncertainty been sufficiently and reasonably addressed? Have sufficient models been used to address all reasonably foreseeable biotopes? Are the transitions between biotopes modelled adequately (specifically, are initial conditions for developing biotopes adequately specified by calculations for subsiding biotopes)? Have all critical radionuclides been identified? It is concluded that, in general, the assumptions underlying most of the models are justifiable. The exceptions are a) the rather simplistic approach taken in the Coastal Model and b) the lack of consideration of wild foods and age-dependence when calculating exposures of humans to radionuclides via dietary pathways. Most foreseeable processes appear to have been accounted for within the constraints of the models used, although it is recommended that attention be paid to future climate states when considering

  20. Technical note 1. Review of the Geomicrobiological Aspects of SKB's Licence Application for a Spent Nuclear Fuel Repository in Forsmark, Sweden

    International Nuclear Information System (INIS)

    Parkes, R. John

    2011-10-01

    The report reviews whether the research work by SKB has been adequately comprehensive to describe the influence of microbial activity for sulphide production at repository depth. The report also documents any uncertainties with regard to predictions of rates and consequences of microbial sulphide production. SKB's assessment relies almost entirely on the results of the research that they commissioned from the Univ. of Goeteborg (Pedersen, 2010, Masurat et al., 2010a, b). This is not an unreasonable position, as there is no directly comparable research available. However, there is considerable literature demonstrating continued activity of sulphate-reducing bacteria over geological time scales and enhanced activity of sulphate-reducing bacteria in interaction with metals and corrosion, that should also be taken into consideration when assessing potential microbially influenced corrosion (Beech and Sunner, 2007) of the copper canister

  1. Hydrochemical investigations in crystalline bedrock in relation to existing hydraulic conditions: experiences from the SKB test-sites in Sweden

    International Nuclear Information System (INIS)

    Smellie, J.; Larsson, N.Aa.; Wikberg, P.; Carlsson, L.

    1985-11-01

    This report represents the compilation, discussion and interpretation of hydrochemical and hydraulic data resulting from the SKB test-site investigations carried out over a period of three years (1982-84). By systematically applying hydrological and geological considerations to each sampled horizon, it has been possible to differentiate between those groundwaters which are reasonably representative for the depth sampled, from those which have been subject to contamination from different sources. Groundwaters which are here considered representative are defined as those which show no evidence of mixing with other water sources, whether from drilling water, younger, near-surface water, or other deeper groundwaters. As a consequence, only a few sampled horizons can be considered with serious hydrochemical attention. The lack of representative groundwater samples, whilst often due to technical problems or sampling from non-conductive sections of the boreholes, also illustrate the extremely complex geometry of the premeable fracture systems in crystalline bedrock, and thus the difficulty of establishing the nature and depth relation of the groundwater tapped. Although the main findings of this study have revealed gross inadequacies in the hydrochemical programme, valuable experience has nevertheless been gained. Consequently, some of the improvements recommended in Section 7 of this report have been already implemented resulting in higher sampling standards and thus water samples which are much more representative for the hydrogeological environment under investigation. (author)

  2. The post-closure radiological safety case for a spent fuel repository in Sweden - An international peer review of the SKB license-application study of March 2011

    International Nuclear Information System (INIS)

    2012-01-01

    Sweden is at the forefront among countries developing plans for a deep geological repository of highly radioactive waste. There is no such repository in operation yet worldwide, but Sweden, Finland and France are approaching the licensing stage. At the request of the Swedish government, the NEA organised an international peer review of the post-closure radiological safety case produced by the Swedish Nuclear Fuel and Waste Management Company (SKB) in support of the application for a general licence to construct and operate a spent nuclear fuel geological repository in the municipality of Oesthammar. The purpose of the review was to help the Swedish government, the public and relevant organisations by providing an international reference regarding the maturity of SKB's spent fuel disposal programme vis-a-vis best practices in long-term disposal safety and radiological protection. The International Review Team (IRT) consisted of ten international specialists, who were free of conflict of interest with the SKB and brought complementary expertise to the review. This report provides the background and findings of the international peer review. The review's findings are presented at several levels of detail in order to be accessible to both specialist and non-specialist readers

  3. Rock-block characterization on regional to local scales for two SKB sites in Forsmark - Uppland and Laxemar - eastern Smaaland, south-eastern Sweden

    International Nuclear Information System (INIS)

    Beckholmen, Monica; Tiren, Sven A.

    2010-11-01

    Digital elevation data in 500m, 50m and 10m grids were used for rock-block interpretations at regional, semi-regional and local scales of areas around the two SKB sites, Forsmark and Laxemar, objects for the site-investigation programme. Both areas are interpreted to be close to the surface of the sub- Cambrian peneplain and varying altitude and attitude may testify to blockfaulting in the distorted peneplain. Topographic breaks and changes in the gradient also reveal possible zones of weakness that may conduct water. Rock blocks were constructed for Uppland at 1:750 000, northern Uppland at 1:450 000 and the local Forsmark area at 1:150 000, three sets were constructed for eastern Smaaland at 1:500 000, and one for the semi-regional area at 1:250 000 and one for the local Laxemar area at 1:75 000. The orientation of rock-block boundaries and the size of the rock blocks were treated statistically. The rock blocks/polygons were analysed for their mean, minimum and maximum elevation and the range. The values were displayed by maps. The topography in especially eastern Smaaland is dominated by a clear gradient, the land rising from the sea in the east. Efforts were therefore made to remove an estimated gradient to assess the residual features and the same analyses were then made for mean, maximum, minimum and range values. In many cases the results were enhanced and the two types of presentations are complementary to each other. The rock-block interpretations were compared to bedrock and general correlation between major structures where identified. However, the distribution of rocks on a regional map often demonstrates the plastic deformation in a wider zone. Earthquake epicentres were combined with the rock-block maps and assuming that interpreted rock-block boundaries are fairly steep, there is good agreement between the location of epicentres and rock-block boundaries. In some cases it can be seen how seismic disturbance migrated along a structure. Many

  4. Exploration of cervical carotid stenosis using helical CT angiography. A prospective trial on the detection of candidates for surgery in the Gujo area, Gifu

    Energy Technology Data Exchange (ETDEWEB)

    Yamakawa, Hiroyasu; Sumi, Yasuhiko [Sumi Hospital, Gifu (Japan); Kaku, Yasuhiko; Sakai, Noboru; Yamada, Hiromu

    1995-04-01

    To detect cervical carotid stenosis as a candidate for carotid endarterectomy (CEA), the authors attempted a prospective trial by exploring stenosis for one year in a rural district with a population of 20,000, employing helical CT angiography which apparently displayed three-dimensional reconstructed images of the carotid bifurcation. Thirty-three patients, 24 males and 9 females, with a mean age of 71.8 years, suffering from TIA, RIND or stroke were investigated for their carotid systems. The clinical symptoms of the patients were briefly as follows: motor weakness in 30 cases, dysarthria in 8 cases and aphasia in 4 cases; and 6 of 22 (27%) stroke cases had previously suffered an episode of TIA. The risk factors of the whole group of patients were hypertension in 13 cases, diabetes mellitus in 6, heart disease in 17, and hypercholesteremia in 4. Helical CT angiography was performed in 11 cases of TIA, 2 cases of RIND, and 16 cases of stroke. Only 3 cases of the TIA group and 3 cases of the stroke group were found to have extracranial carotid stenosis of more than 50%, which subsequently required conventional angiography. For the detection of stenosis, CT angiography was beneficial as well as conventional angiography. Finally, CEA was performed in 2 of 3 cases with severe carotid stonosis in the TIA group, while such cases in the stroke group were only observed. The above results meant that the occurrence of extracranial carotid stenosis was 6 out of 6,589 elderly inhabitants (over 60 years old), although the possible detection rate of candidates for CEA was 2 out of 20,000 population per year. (author).

  5. Exploration of cervical carotid stenosis using helical CT angiography. A prospective trial on the detection of candidates for surgery in the Gujo area, Gifu

    International Nuclear Information System (INIS)

    Yamakawa, Hiroyasu; Sumi, Yasuhiko; Kaku, Yasuhiko; Sakai, Noboru; Yamada, Hiromu.

    1995-01-01

    To detect cervical carotid stenosis as a candidate for carotid endarterectomy (CEA), the authors attempted a prospective trial by exploring stenosis for one year in a rural district with a population of 20,000, employing helical CT angiography which apparently displayed three-dimensional reconstructed images of the carotid bifurcation. Thirty-three patients, 24 males and 9 females, with a mean age of 71.8 years, suffering from TIA, RIND or stroke were investigated for their carotid systems. The clinical symptoms of the patients were briefly as follows: motor weakness in 30 cases, dysarthria in 8 cases and aphasia in 4 cases; and 6 of 22 (27%) stroke cases had previously suffered an episode of TIA. The risk factors of the whole group of patients were hypertension in 13 cases, diabetes mellitus in 6, heart disease in 17, and hypercholesteremia in 4. Helical CT angiography was performed in 11 cases of TIA, 2 cases of RIND, and 16 cases of stroke. Only 3 cases of the TIA group and 3 cases of the stroke group were found to have extracranial carotid stenosis of more than 50%, which subsequently required conventional angiography. For the detection of stenosis, CT angiography was beneficial as well as conventional angiography. Finally, CEA was performed in 2 of 3 cases with severe carotid stonosis in the TIA group, while such cases in the stroke group were only observed. The above results meant that the occurrence of extracranial carotid stenosis was 6 out of 6,589 elderly inhabitants (over 60 years old), although the possible detection rate of candidates for CEA was 2 out of 20,000 population per year. (author)

  6. The Swedish Nuclear Power Inspectorate's evaluation of SKB's RD and D Program 98. Review report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-04-01

    According to the Act (1984:3) on Nuclear Activities, the full responsibility for the safe management and final disposal of spent nuclear fuel and nuclear waste rests with the owners of the Swedish nuclear power reactors. In accordance with the Act (1992:1537) on the Financing of Future Expenses for Spent Nuclear Fuel etc., the owners are also responsible for ensuring that funds are set aside to cover the future expenses of the management and final disposal of spent nuclear fuel and nuclear waste. Furthermore, nuclear reactor owners must conduct, and every three years, submit a research and development programme for the management of the spent nuclear fuel and nuclear waste. The programme must also cover the measures which are necessary for the decommissioning and dismantling of the nuclear installations. SKI must submit the programme documents to the Government, along with its own statement. The owners of the nuclear power reactors have formed a joint company, SKB which, on behalf of the owners, fulfils the owners' statutory obligations with respect to the management and final disposal of spent nuclear fuel and nuclear waste and conducts related research and development. The programme now submitted by SKB is the latest in the series which started with RandD Programme 86. The current programme was submitted in September 1998 and is called RDandD Programme 98 (programme for Research, Development and Demonstration). In RDandD Programme 98, SKB has stated that it particularly welcomes viewpoints concerning: Whether deep disposal according to the KBS-3 method will continue to be the preferred method. The body of material that SKB is compiling in preparation for the selection of sites for site investigation. What is to be included in future Environmental Impact Statements (EIS). Compared to previous programmes, RDandD Programme 98 is focused to a greater extent on method and site selection and on issues relating to the decision-making process. In order to emphasise

  7. Review of SR-Can: Evaluation of SKB's handling of spent fuel performance, radionuclide chemistry and geosphere transport parameters. External review contribution in support of SKI's and SSI's review of SR-Can

    International Nuclear Information System (INIS)

    Stenhouse, Mike; Jegou, Christophe; Brown, Paul; Meinrath, Guenther; Nitsche, Heino; Ekberg, Christian

    2008-03-01

    SR-Can covers the containment phase of the KBS-3 barriers as well as the consequences of releases of radionuclides to the rock and eventually the biosphere (after complete containment within fuel canisters has partially failed). The aim of this report is to provide a range of review comments with respect to those parameters related to spent fuel performance as well as radionuclide chemistry and transport. These parameter values are used in the quantification of consequences due to release of radionuclides from potentially leaking canisters. The report does not cover modelling approaches used for quantification of consequences. However, modelling used to derive parameter values is to some extent addressed (such as calculation of maximum radionuclide concentration due to formation of solubility limiting phases). The following are the key highlights and comments generated in the course of the review: Inconsistencies exist between recommendations provided in technical reports and those quoted in the Data Report. One of the reasons for such inconsistencies has been the timing of different pieces of research. It is hoped that the timing of contributions to SR-Site will be such that these inconsistencies can be avoided. Sensitivity analyses need to be carried out and reported in a number of areas to support some of the assumptions or decisions made in the assessment calculations. The likelihood is that SKB has performed many of the sensitivity analyses identified in different parts of this report, but these need to be reported, preferably to complement the recommendations provided

  8. Deep repository for long-lived low- and intermediate-level waste in Sweden (SFL 3-5): An international peer review of SKB 's preliminary safety assessment

    International Nuclear Information System (INIS)

    Chapman, N.; Apted, M.; Glasser, F.; Voss, C.

    2000-10-01

    The SKB safety assessment of the SFL 3-5 repository (the planned deep repository for long-lived low- and intermediate level waste) can be read in two contexts: as a preliminary evaluation of the performance and design options for a repository that will not be required for perhaps forty years; or as an evaluation of a repository that might need to be sited together with the SFL 2 spent fuel repository, and whose nature and performance might thus need to be understood to a level that can be used to make wider programmatic decisions during the next five years. These two 'assessment contexts' are quite different, and an overarching issue is the fact that it was not clear to the review team which view to take. Apparently, SKB would tend towards the first context. However, it is not at all apparent to the reviewers why the second context should not be the predominant driver in the near future. The review team notes that the SFL 3-5 repository, as modelled by SKB, gives rise to potentially perceptible radionuclide releases to the environment on a timescale of hundreds of years after closure. This is in contrast to the SR 97 assessment for the SFL 2 spent fuel repository, which base scenario predicts no releases over a million year timescale. It is clear that according to SKB's SR97 and SFL3-5 analyses, for co-located facilities, it is this repository that has the potential for real radiological impacts in the immediate future. An initial recommendation from the review, is that SKB and the regulatory authorities consider which context is appropriate to the current status of the Swedish programme. This is important, because an overall impression of the reviewers is that the analysis would not be 'fit for purpose' if it were needed to assist with decision-making by SKB or the regulatory agencies. There are too many unanswered questions, and the overall impression of the safety concept is one of some fragility. Because there is no real design basis presented, no thorough

  9. Citizen Candidates Under Uncertainty

    OpenAIRE

    Eguia, Jon X.

    2005-01-01

    In this paper we make two contributions to the growing literature on "citizen-candidate" models of representative democracy. First, we add uncertainty about the total vote count. We show that in a society with a large electorate, where the outcome of the election is uncertain and where winning candidates receive a large reward from holding office, there will be a two-candidate equilibrium and no equilibria with a single candidate. Second, we introduce a new concept of equilibrium, which we te...

  10. Description of surface systems. Preliminary site description Simpevarp sub area - Version 1.2

    International Nuclear Information System (INIS)

    Lindborg, Tobias

    2005-03-01

    Swedish Nuclear Fuel and Waste Management Co is currently conducting site characterisation in the Simpevarp area. The area is divided into two subareas, the Simpevarp and the Laxemar subarea. The two subareas are surrounded by a common regional model area, the Simpevarp area. This report describes both the regional area and the subareas. This report is an interim version (model version 1.2) of the description of the surface systems at the Simpevarp area, and should be seen as a background report to the site description of the Simpevarp area, version 1.2, SKB-R--05-08. The basis for this description is quality-assured field data available in the SKB SICADA and GIS databases, together with generic data from the literature. The Surface system, here defined as everything above the bedrock, comprises a number of separate disciplines (e.g. hydrology, geology, topography, oceanography and ecology). Each discipline has developed descriptions and models for a number of properties that together represent the site description. The current methodology for developing the surface system description and the integration to ecosystem models is documented in a methodology strategy report SKB-R--03-06. The procedures and guidelines given in that report were followed in this report. Compared with version 1.1 of the surface system description SKB-R--04-25, this report presents considerable additional features, especially in the ecosystem description (Chapter 4) and in the description of the surface hydrology (Section 3.4). A first attempt has also been made to connect the flow of matter (carbon) between the different ecosystems into an overall ecosystem model at a landscape level. A summarised version of this report is also presented in SKB-R--05-08 together with geological-, hydrogeological-, transport properties-, thermal properties-, rock mechanics- and hydrogeochemical descriptions

  11. Description of surface systems. Preliminary site description Simpevarp sub area - Version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Lindborg, Tobias (ed.)

    2005-03-01

    Swedish Nuclear Fuel and Waste Management Co is currently conducting site characterisation in the Simpevarp area. The area is divided into two subareas, the Simpevarp and the Laxemar subarea. The two subareas are surrounded by a common regional model area, the Simpevarp area. This report describes both the regional area and the subareas. This report is an interim version (model version 1.2) of the description of the surface systems at the Simpevarp area, and should be seen as a background report to the site description of the Simpevarp area, version 1.2, SKB-R--05-08. The basis for this description is quality-assured field data available in the SKB SICADA and GIS databases, together with generic data from the literature. The Surface system, here defined as everything above the bedrock, comprises a number of separate disciplines (e.g. hydrology, geology, topography, oceanography and ecology). Each discipline has developed descriptions and models for a number of properties that together represent the site description. The current methodology for developing the surface system description and the integration to ecosystem models is documented in a methodology strategy report SKB-R--03-06. The procedures and guidelines given in that report were followed in this report. Compared with version 1.1 of the surface system description SKB-R--04-25, this report presents considerable additional features, especially in the ecosystem description (Chapter 4) and in the description of the surface hydrology (Section 3.4). A first attempt has also been made to connect the flow of matter (carbon) between the different ecosystems into an overall ecosystem model at a landscape level. A summarised version of this report is also presented in SKB-R--05-08 together with geological-, hydrogeological-, transport properties-, thermal properties-, rock mechanics- and hydrogeochemical descriptions.

  12. A summary of INSITE activities in tracking SKB's spent fuel repository site investigations from 2002-2009 and of advice provided to the regulatory authorities on the status of site understanding at the end of the surface-based investigations

    International Nuclear Information System (INIS)

    Chapman, Neil; Bath, Adrian; Geier, Joel; Ove Stephansson; Tiren, Sven; Tsang, Chin-Fu

    2010-11-01

    SSM and its predecessor SKI employed a team of earth scientists who followed and reviewed SKB's investigations of the potential spent nuclear fuel repository sites at Forsmark and Laxemar. This group was named INSITE (INdependent Site Investigation Tracking and Evaluation) and began its work in 2002 and completed its task with the review of the final versions SKB's site descriptive models, SDM-Site, in 2009. This report is a summary of INSITE's work over the eight-and-a-half year period of the site investigations and the lead-in and the wind-down to the work. It is intended to provide an outline and a record of how INSITE has worked and how its advice was generated and provided to SKI and, latterly, to SSM. Together with all the other documentation generated by INSITE, this report is intended to support the regulatory review of SKB's licence application for a spent nuclear fuel repository

  13. The potential for ore, industrial minerals and commercial stones in the Simpevarp area

    Energy Technology Data Exchange (ETDEWEB)

    Lindroos, Hardy [MIRAB Mineral Resurser AB, Uppsla (Sweden)

    2004-10-01

    On behalf of SKB (the Swedish Nuclear Fuel and Waste Management Company), a survey has been made of existing information concerning the potential for ore, industrial minerals and commercial stones in and around the two candidate areas for a deep repository in Oskarshamn. A deep repository for spent nuclear fuel should not be located in a rock type or in an area where mineral extraction might be considered in the future, since this would make it difficult or impossible to exploit this natural resource. Avoiding such areas reduces the risk that people in the future will come into contact with the deep repository through mineral prospecting or mining activities.The survey has made use of the geoscientific information compiled in the more regional investigations in Oskarshamn Municipality in 1998-99. The new information after the municipal study includes extensive geophysical measurements from both the air and the ground. The results of the recently completed geophysical helicopter survey of the Simpevarp area are presented in a special chapter. The judgement of an area's ore potential is in part based on the evaluation of these geophysical measurements. In order to be better able to judge the ore potential, a geochemical investigation of soil samples, including reanalysing of older samples collected by the Geological Survey of Sweden (SGU), has been carried out. The report also discusses prospecting efforts in the area as well as relevant Swedish mining legislation. In cooperation with SGU a mineral resource map of the Simpevarp area has been prepared. The map shows two areas with a potential for commercial stones, namely the granites at Goetemar and Uthammar, situated in the northernmost respectively the southernmost part of the study area. Furthermore, the Goetemar granite has probably a small potential for ores containing tin (Sn) and/or wolfram (W). Although no mineralizations of this type have so far been found, the Goetemar granite area may be unsuitable or

  14. A comparison between standard well test evaluation methods used in SKB's site investigations and the generalised radial flow concept

    International Nuclear Information System (INIS)

    Follin, Sven; Ludvigson, Jan-Erik; Leven, Jakob

    2011-09-01

    According to the strategy for hydrogeological characterisation within the SKB's site investigation programme, two single-hole test methods are available for testing and parameterisation of groundwater flow models - constant-head injection testing with the Pipe String System (PSS method) and difference flow logging with the Posiva Flow Log (PFL method). This report presents the results of an investigation to assess discrepancies in the results of single-hole transmissivity measurements using these methods in the Forsmark site characterisation. The investigation explores the possibility that the source of the discrepancy observed lies in the assumptions of the flow geometry that are inherent to the methods used for standard constant-head injection well test analysis and difference flow logging analysis, respectively. In particular, the report looks at the generalised radial flow (GRF) concept by Barker (1988) as a means that might explain some of the differences. A confirmation of the actual flow geometries (dimensions) observed during hydraulic injection tests could help to identify admissible conceptual models for the tested system, and place the hydraulic testing with the PSS and PFL test methods in its full hydrogeological context. The investigation analyses 151 constant-head injection tests in three cored boreholes at Forsmark. The results suggest that the transmissivities derived with standard constant-head injection well test analysis methods and with the GRF concept, respectively, are similar provided that the dominating flow geometry during the testing is radial (cylindrical). Thus, having flow geometries with dimensions other than 2 affects the value of the interpreted transmissivity. For example, a flow system with a dimension of 1 may require an order of magnitude or more, higher transmissivity to produce the same flow rates. The median of the GRF flow dimensions of all 151 constant-head injection tests is 2.06 with 33% of the tests in the range 1

  15. Hydraulic interaction of engineered and natural barriers. Task 8b-8d and 8f of SKB

    Energy Technology Data Exchange (ETDEWEB)

    Kroehn, Klaus-Peter

    2017-04-15

    The Task Force on Groundwater Flow and Transport of Solutes (TF GWFTS) and the Task Force on Engineered Barrier Systems (TF EBS) both established by the Svensk Kaernbraenslehantering AB (SKB) have defined the so-called Task 8 to investigate the hydraulic interaction of the granitic host rock at the Hard Rock Laboratory at Aespoeand the bentonite clay buffer in a deep geological repository. Task 8 a-d ran parallel to the related BRIE-project (Bentonite Rock Interaction Experiment) at the AespoeHard Rock Laboratory (HRL). The BRIE-project was concerned with an in-situ test where two boreholes were drilled from a tunnel floor and filled with compacted bentonite. Task 8 encompassed obviously characterizing the groundwater flow field as well as simulating bentonite re-saturation. Described here is an approach to solve the problem by decoupling both aspects. Groundwater flow was simplified to a steady-state single-phase flow model including discretely described large fractures. Modelling was performed with the code d{sup 3}f. Outflow data from the rock was then assigned to the inflow boundary of the alternative re-saturation model realized in the experimental code VIPER. With increasing knowledge about the site the upcoming data and the accompanying flow modelling indicated an inherent problem with predictions for the site and borehole characterization. Specific (deterministic) answers were sought from a flow domain that contains a relevant water-bearing fracture network which is only known in terms of geostatistics. While the overall flow regime could be represented in the final model the results were therefore not detailed below the scale of the boreholes. Early data from the flow model had indicated that water uptake of the bentonite at the bentonite-matrix contact would occur under restricted access to water. This had not been considered in laboratory tests up to then and also not in VIPER. A new appropriate boundary condition was developed and implemented. The time

  16. Automating the production of high-purity zirconium from waste products in industrial furnaces SKB-5025 and apparatuses TS-40M

    International Nuclear Information System (INIS)

    Lavrikov, S.A.; Kotsar', M.L.; Lapidus, A.O.; Akhtonov, S.G.; Aleksandrov, A.V.; Ogorodnikov, L.V.; Chernyshev, A.A.; Kopysov, N.V.

    2014-01-01

    A disadvantage of iodide refining of zirconium in industrial furnaces in the processing of waste products production in JSC CMP is the low direct yield of the metal in iodide rods and large energy consumption of the process. The aim of this work is to optimize the process by means of automated control. The paper deals with the creation of a test unit to automate the iodide refining of zirconium in JSC CMP. The main features of the unit, the hardware and software of the automated unit and the results of its work during the operation are described. A scheme for the automation of 10 furnaces SKB-5025 by optimizing the total cost of computing equipment and for software improvements was proposed and implemented in 2012

  17. Black hole candidates

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Black hole candidates. In the case of X-ray sources such as Cyg X-1, the mass of the compact object inferred from combined optical and X-ray data, suggest M_compact object > 3.4 M_sun => Black Hole! A remarkable discovery!! Thus X-ray emitting binary systems ...

  18. Primary and Presidential Candidates

    DEFF Research Database (Denmark)

    Goddard, Joseph

    2012-01-01

    This article looks at primary and presidential candidates in 2008 and 2012. Evidence suggests that voters are less influenced by candidates’ color, gender, or religious observation than previously. Conversely, markers of difference remain salient in the imaginations of pollsters and journalists......, and appear in opinion polls and newspaper columns....

  19. Supersymmetric Dark Matter Candidates

    CERN Document Server

    Ellis, John

    2010-01-01

    After reviewing the theoretical, phenomenological and experimental motivations for supersymmetric extensions of the Standard Model, we recall that supersymmetric relics from the Big Bang are expected in models that conserve R parity. We then discuss possible supersymmetric dark matter candidates, focusing on the lightest neutralino and the gravitino. In the latter case, the next-to-lightest supersymmetric particle is expected to be long-lived, and possible candidates include spartners of the tau lepton, top quark and neutrino. We then discuss the roles of the renormalization-group equations and electroweak symmetry breaking in delimiting the supersymmetric parameter space. We discuss in particular the constrained minimal extension of the Standard Model (CMSSM), in which the supersymmetry-breaking parameters are assumed to be universal at the grand unification scale, presenting predictions from a frequentist analysis of its parameter space. We also discuss astrophysical and cosmological constraints on gravitin...

  20. Dark matter candidates

    International Nuclear Information System (INIS)

    Turner, M.S.

    1989-01-01

    One of the simplest, yet most profound, questions we can ask about the Universe is, how much stuff is in it, and further what is that stuff composed of? Needless to say, the answer to this question has very important implications for the evolution of the Universe, determining both the ultimate fate and the course of structure formation. Remarkably, at this late date in the history of the Universe we still do not have a definitive answer to this simplest of questions---although we have some very intriguing clues. It is known with certainty that most of the material in the Universe is dark, and we have the strong suspicion that the dominant component of material in the Cosmos is not baryons, but rather is exotic relic elementary particles left over from the earliest, very hot epoch of the Universe. If true, the Dark Matter question is a most fundamental one facing both particle physics and cosmology. The leading particle dark matter candidates are: the axion, the neutralino, and a light neutrino species. All three candidates are accessible to experimental tests, and experiments are now in progress. In addition, there are several dark horse, long shot, candidates, including the superheavy magnetic monopole and soliton stars. 13 refs

  1. Teachers Candidates' Reviews on Teacher Candidate Training System

    Science.gov (United States)

    Altintas, Sedat; Görgen, Izzet

    2017-01-01

    In our country, as a result of the appointment in some different disciplines, nearly 30000 teacher candidates could be a part of education system. Also, a new revision has been completed on teacher candidate training and it has been put into action. Teacher candidates have been trained for six months after they have been appointed. These teachers…

  2. Review of SR-Can: Evaluation of SKB's handling of spent fuel performance, radionuclide chemistry and geosphere transport parameters. External review contribution in support of SKI's and SSI's review of SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Stenhouse, Mike (Monitor Scientific LLC, Denver, CO (US)); Jegou, Christophe (Commissariat a l' Energie Atomique (CEA) (FR)); Brown, Paul (Geochem Australia (AU)); Meinrath, Guenther (RER Consultants, Passau (DE)); Nitsche, Heino (Univ. of California, Berkeley (US)); Ekberg, Christian (Chalmers University of Technology (SE))

    2008-03-15

    SR-Can covers the containment phase of the KBS-3 barriers as well as the consequences of releases of radionuclides to the rock and eventually the biosphere (after complete containment within fuel canisters has partially failed). The aim of this report is to provide a range of review comments with respect to those parameters related to spent fuel performance as well as radionuclide chemistry and transport. These parameter values are used in the quantification of consequences due to release of radionuclides from potentially leaking canisters. The report does not cover modelling approaches used for quantification of consequences. However, modelling used to derive parameter values is to some extent addressed (such as calculation of maximum radionuclide concentration due to formation of solubility limiting phases). The following are the key highlights and comments generated in the course of the review: Inconsistencies exist between recommendations provided in technical reports and those quoted in the Data Report. One of the reasons for such inconsistencies has been the timing of different pieces of research. It is hoped that the timing of contributions to SR-Site will be such that these inconsistencies can be avoided. Sensitivity analyses need to be carried out and reported in a number of areas to support some of the assumptions or decisions made in the assessment calculations. The likelihood is that SKB has performed many of the sensitivity analyses identified in different parts of this report, but these need to be reported, preferably to complement the recommendations provided

  3. Characterization of Discharge Areas of Radionuclides Originating From Nuclear Waste Repositories

    Science.gov (United States)

    Marklund, L.; Xu, S.; Worman, A.

    2009-05-01

    If leakages in nuclear waste repositories located in crystalline bedrock arise, radionuclides will reach the biosphere and cause a risk of radiological impact. The extent of the radiological impact depends on in which landscape elements the radionuclides emerge. In this study, we investigate if there are certain landscape elements that generally will act as discharge areas for radionuclides leaking from subsurface deposits. We also characterize the typical properties that distinguish these areas from others. In humid regions, landscape topography is the most important driving force for groundwater flow. Because groundwater is the main transporting agent for migrating radionuclides, the topography will determine the flowpaths of leaking radionuclides. How topography and heterogeneities in the subsurface affect the discharge distribution of the radionuclides is therefore an important scope of this study. To address these issues, we developed a 3-D transport model. Our analyses are based on site-specific data from two different areas in Sweden, Forsmark, Uppland, and Oskarshamn, Småland. The Swedish Nuclear Waste Management Company (SKB) has selected these two areas as candidate areas for a deep repository of nuclear waste and the areas are currently subject to site investigations. Our results suggest that there are hot-spots in the landscape i.e. areas with high probability of receiving large amounts of radionuclides from a leaking repository of nuclear waste. The hot-spots concentrate in the sea, streams, lakes and wetlands. All these elements are found at lower elevations in the landscape. This pattern is mostly determined by the landscape topography and the locations of fracture zones. There is a relationship between fracture zones and topography, and therefore the importance of the topography for the discharge area distribution is not contradicted by the heterogeneity in the bedrock. The varieties of landscape elements which have potential for receiving

  4. Candidal Leukoplakia on Patient with Removable Denture

    Directory of Open Access Journals (Sweden)

    Shiril Paskalis

    2013-07-01

    Full Text Available Candida infection is a common problem in patients using removable dentures, with the most frequent type is denture stomatitis. But other type of candidal infection could also happen in these patients, such as candidal leukoplakia. We reported a 61 years old female patient who complained a painful lesion under her lower removable denture. Oral examination revealed white plaque that could not be rubbed over an ulcer on the lingual part of alveolar processes under the lower removable denture plate, and also an erythematous area on palatum durum above the upper full denture. The patient was suspected to have candidal leukoplakia on the lingual part of the mandible and denture stomatitis on the palate area. The treatment consisted of nystatin oral suspension, chlorhexidine solution, multivitamins, along with denture replacement and oral health education. The entire lesion resolved within 2 months therapy. Candidal infection treatment on denture patient needs not only medication or denture replacement, but also patient compliance to achieve maximal result.

  5. Report on the access to the deposition areas of the repository. Shaft or Ramp?

    International Nuclear Information System (INIS)

    Baeckblom, Goeran; Christiansson, Rolf; Hedin, Allan; Norman, Fredrik; Lagerstedt, Leif

    2003-05-01

    During year 2002, SKB launched the site-specific engineering of the repository at the Oskarshamn and Oesthammar candidate sites. A part of the ongoing engineering work is to evaluate and possibly select type of access from surface to the underground deposition areas located at a depth of some 400 to 700 metres below the surface. The project objectives are to provide a basis for comparison and to compare generic options for access routes to the underground deposition areas, to formulate preliminary Design Justification Statements for the continued site-specific engineering of access routes to the underground repository and also to describe and exemplify methodology for optimisation of the repository engineering. In consideration of the requirements of SKB, several alternative access options are explored. The main alternatives are a ramp with one or two operational areas at the surface, a ramp with parallel excavation of a blind shaft and an alternative with shafts only. A suite of objective functions were employed in the evaluation of the main alternatives relating to long-term safety, occupational safety during construction and operation, environmental impact, sustainability of natural resources, total cost, schedules, flexibility and project risks. All alternatives studied are feasible and safe, but the alternative with a spiral ramp and a blind shaft is deemed to be the most favourable option. The alternative has the highest flexibility without any tangible disadvantages related neither to long-term safety, environmental impact nor to schedules. It is an advantage that ramp traffic is drastically reduced as rock and backfilling material is transported by the skip rather than by vehicles in the ramp, thereby reducing risks of accidents and fires in the ramp. The concurrent ramp and shaft excavation also shorten the construction period with 18 months for the underground excavations. The discounted total cost is however 100 million Swedish Kronor higher for this

  6. CHK2, A Candidate Prostate Cancer Susceptibility Gene

    National Research Council Canada - National Science Library

    Liu, Wanguo

    2005-01-01

    .... However, this area has been understudied in prostate cancer. In this study, we tested our hypothesis that genetic defects in this pathway may confer susceptibility to prostate cancer using a mutation screening of candidate gene approach...

  7. Deep repository for long-lived low- and intermediate-level waste in Sweden (SFL 3-5): An international peer review of SKB 's preliminary safety assessment

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, N. [QuantiSci Ltd, Melton Mowbray (United Kingdom); Apted, M. [Monitor Scientific, Denver, CO (United States); Glasser, F. [Univ. of Aberdeen (United Kingdom). Dept. of Chemistry; Kessler, J. [EPRI, Inc., Palo Alto, CA (United States); Voss, C. [US Geological Survey, Reston, VA (United States)

    2000-10-01

    The SKB safety assessment of the SFL 3-5 repository (the planned deep repository for long-lived low- and intermediate level waste) can be read in two contexts: as a preliminary evaluation of the performance and design options for a repository that will not be required for perhaps forty years; or as an evaluation of a repository that might need to be sited together with the SFL 2 spent fuel repository, and whose nature and performance might thus need to be understood to a level that can be used to make wider programmatic decisions during the next five years. These two 'assessment contexts' are quite different, and an overarching issue is the fact that it was not clear to the review team which view to take. Apparently, SKB would tend towards the first context. However, it is not at all apparent to the reviewers why the second context should not be the predominant driver in the near future. The review team notes that the SFL 3-5 repository, as modelled by SKB, gives rise to potentially perceptible radionuclide releases to the environment on a timescale of hundreds of years after closure. This is in contrast to the SR 97 assessment for the SFL 2 spent fuel repository, which base scenario predicts no releases over a million year timescale. It is clear that according to SKB's SR97 and SFL3-5 analyses, for co-located facilities, it is this repository that has the potential for real radiological impacts in the immediate future. An initial recommendation from the review, is that SKB and the regulatory authorities consider which context is appropriate to the current status of the Swedish programme. This is important, because an overall impression of the reviewers is that the analysis would not be 'fit for purpose' if it were needed to assist with decision-making by SKB or the regulatory agencies. There are too many unanswered questions, and the overall impression of the safety concept is one of some fragility. Because there is no real design basis

  8. The underwater acoustic environment at SGaan Kinghlas-Bowie Seamount Marine Protected Area: Characterizing vessel traffic and associated noise using satellite AIS and acoustic datasets.

    Science.gov (United States)

    Allen, Ainsley S; Yurk, Harald; Vagle, Svein; Pilkington, James; Canessa, Rosaline

    2018-03-01

    Vessel traffic is one of the most wide-spread anthropogenic contributors to ocean noise worldwide and has the potential to alter ecosystems upon which cetaceans and other acoustically sensitive marine organisms rely. Canada's SGaan Kinghlas-Bowie Seamount Marine Protected Area (SK-B MPA) is one such area whose productive ecosystem could benefit from greater monitoring of human induced threats in order to inform management. Despite earning official designation as a Marine Protected Area under the Oceans Act in 2008, little remains known about vessel traffic in the region and the associated potential impacts on vulnerable marine species. Therefore, to increase our understanding of vessel traffic and accompanying noise at SK-B MPA, satellite AIS and acoustic data were investigated. The results of this study suggest that variations in ambient sound levels in the region are driven by near and distant shipping events, thus having implications for future management of the MPA. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. Electoral Systems and Candidate Selection

    NARCIS (Netherlands)

    Hazan, Reuven Y.; Voerman, Gerrit

    Electoral systems at the national level and candidate selection methods at the party level are connected, maybe not causally but they do influence each other. More precisely, the electoral system constrains and conditions the parties' menu of choices concerning candidate selection. Moreover, in

  10. Automatic Classification of Kepler Planetary Transit Candidates

    Science.gov (United States)

    McCauliff, Sean D.; Jenkins, Jon M.; Catanzarite, Joseph; Burke, Christopher J.; Coughlin, Jeffrey L.; Twicken, Joseph D.; Tenenbaum, Peter; Seader, Shawn; Li, Jie; Cote, Miles

    2015-06-01

    In the first three years of operation, the Kepler mission found 3697 planet candidates (PCs) from a set of 18,406 transit-like features detected on more than 200,000 distinct stars. Vetting candidate signals manually by inspecting light curves and other diagnostic information is a labor intensive effort. Additionally, this classification methodology does not yield any information about the quality of PCs; all candidates are as credible as any other. The torrent of exoplanet discoveries will continue after Kepler, because a number of exoplanet surveys will have an even broader search area. This paper presents the application of machine-learning techniques to the classification of the exoplanet transit-like signals present in the Kepler light curve data. Transit-like detections are transformed into a uniform set of real-numbered attributes, the most important of which are described in this paper. Each of the known transit-like detections is assigned a class of PC; astrophysical false positive; or systematic, instrumental noise. We use a random forest algorithm to learn the mapping from attributes to classes on this training set. The random forest algorithm has been used previously to classify variable stars; this is the first time it has been used for exoplanet classification. We are able to achieve an overall error rate of 5.85% and an error rate for classifying exoplanets candidates of 2.81%.

  11. A comparison between standard well test evaluation methods used in SKB's site investigations and the generalised radial flow concept

    Energy Technology Data Exchange (ETDEWEB)

    Follin, Sven (SF GeoLogic AB (Sweden)); Ludvigson, Jan-Erik; Leven, Jakob (Geosigma AB (Sweden))

    2011-09-15

    According to the strategy for hydrogeological characterisation within the SKB's site investigation programme, two single-hole test methods are available for testing and parameterisation of groundwater flow models - constant-head injection testing with the Pipe String System (PSS method) and difference flow logging with the Posiva Flow Log (PFL method). This report presents the results of an investigation to assess discrepancies in the results of single-hole transmissivity measurements using these methods in the Forsmark site characterisation. The investigation explores the possibility that the source of the discrepancy observed lies in the assumptions of the flow geometry that are inherent to the methods used for standard constant-head injection well test analysis and difference flow logging analysis, respectively. In particular, the report looks at the generalised radial flow (GRF) concept by Barker (1988) as a means that might explain some of the differences. A confirmation of the actual flow geometries (dimensions) observed during hydraulic injection tests could help to identify admissible conceptual models for the tested system, and place the hydraulic testing with the PSS and PFL test methods in its full hydrogeological context. The investigation analyses 151 constant-head injection tests in three cored boreholes at Forsmark. The results suggest that the transmissivities derived with standard constant-head injection well test analysis methods and with the GRF concept, respectively, are similar provided that the dominating flow geometry during the testing is radial (cylindrical). Thus, having flow geometries with dimensions other than 2 affects the value of the interpreted transmissivity. For example, a flow system with a dimension of 1 may require an order of magnitude or more, higher transmissivity to produce the same flow rates. The median of the GRF flow dimensions of all 151 constant-head injection tests is 2.06 with 33% of the tests in the range 1

  12. Candidate Prediction Models and Methods

    DEFF Research Database (Denmark)

    Nielsen, Henrik Aalborg; Nielsen, Torben Skov; Madsen, Henrik

    2005-01-01

    This document lists candidate prediction models for Work Package 3 (WP3) of the PSO-project called ``Intelligent wind power prediction systems'' (FU4101). The main focus is on the models transforming numerical weather predictions into predictions of power production. The document also outlines...

  13. Candidate cave entrances on Mars

    Science.gov (United States)

    Cushing, Glen E.

    2012-01-01

    This paper presents newly discovered candidate cave entrances into Martian near-surface lava tubes, volcano-tectonic fracture systems, and pit craters and describes their characteristics and exploration possibilities. These candidates are all collapse features that occur either intermittently along laterally continuous trench-like depressions or in the floors of sheer-walled atypical pit craters. As viewed from orbit, locations of most candidates are visibly consistent with known terrestrial features such as tube-fed lava flows, volcano-tectonic fractures, and pit craters, each of which forms by mechanisms that can produce caves. Although we cannot determine subsurface extents of the Martian features discussed here, some may continue unimpeded for many kilometers if terrestrial examples are indeed analogous. The features presented here were identified in images acquired by the Mars Odyssey's Thermal Emission Imaging System visible-wavelength camera, and by the Mars Reconnaissance Orbiter's Context Camera. Select candidates have since been targeted by the High-Resolution Imaging Science Experiment. Martian caves are promising potential sites for future human habitation and astrobiology investigations; understanding their characteristics is critical for long-term mission planning and for developing the necessary exploration technologies.

  14. Teacher Candidate Selection and Evaluation.

    Science.gov (United States)

    Collins, Mary Lynn; And Others

    Summaries are presented of three papers presented at a summer workshop on Quality Assurance in Teacher Education conducted by the Association of Teacher Educators. The general topic covered by these presentations was teacher candidate selection and evaluation. Papers focused upon the following questions: (1) What entry level criteria should be…

  15. Candidate genes in panic disorder

    DEFF Research Database (Denmark)

    Howe, A. S.; Buttenschön, Henriette N; Bani-Fatemi, A.

    2016-01-01

    association studies and ancestry-specific effects. In the present study, we performed a succinct review of case-control association studies published prior to April 2015. Meta-analyses were performed for candidate gene variants examined in at least three studies using the Cochrane Mantel-Haenszel fixed...

  16. Automatic Classification of Kepler Planetary Transit Candidates

    OpenAIRE

    McCauliff, Sean D.; Jenkins, Jon M.; Catanzarite, Joseph; Burke, Christopher J.; Coughlin, Jeffrey L.; Twicken, Joseph D.; Tenenbaum, Peter; Seader, Shawn; Li, Jie; Cote, Miles

    2014-01-01

    In the first three years of operation the Kepler mission found 3,697 planet candidates from a set of 18,406 transit-like features detected on over 200,000 distinct stars. Vetting candidate signals manually by inspecting light curves and other diagnostic information is a labor intensive effort. Additionally, this classification methodology does not yield any information about the quality of planet candidates; all candidates are as credible as any other candidate. The torrent of exoplanet disco...

  17. Report on the access to the deposition areas of the repository. Shaft or Ramp?; Utredning roerande tilltraedesvaegar till djupfoervarets deponeringsomraaden. Schakt eller ramp?

    Energy Technology Data Exchange (ETDEWEB)

    Baeckblom, Goeran [Conrox (Sweden); Christiansson, Rolf; Hedin, Allan; Norman, Fredrik [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Lagerstedt, Leif [SwedPower AB, Stockholm (Sweden)

    2003-05-01

    During year 2002, SKB launched the site-specific engineering of the repository at the Oskarshamn and Oesthammar candidate sites. A part of the ongoing engineering work is to evaluate and possibly select type of access from surface to the underground deposition areas located at a depth of some 400 to 700 metres below the surface. The project objectives are to provide a basis for comparison and to compare generic options for access routes to the underground deposition areas, to formulate preliminary Design Justification Statements for the continued site-specific engineering of access routes to the underground repository and also to describe and exemplify methodology for optimisation of the repository engineering. In consideration of the requirements of SKB, several alternative access options are explored. The main alternatives are a ramp with one or two operational areas at the surface, a ramp with parallel excavation of a blind shaft and an alternative with shafts only. A suite of objective functions were employed in the evaluation of the main alternatives relating to long-term safety, occupational safety during construction and operation, environmental impact, sustainability of natural resources, total cost, schedules, flexibility and project risks. All alternatives studied are feasible and safe, but the alternative with a spiral ramp and a blind shaft is deemed to be the most favourable option. The alternative has the highest flexibility without any tangible disadvantages related neither to long-term safety, environmental impact nor to schedules. It is an advantage that ramp traffic is drastically reduced as rock and backfilling material is transported by the skip rather than by vehicles in the ramp, thereby reducing risks of accidents and fires in the ramp. The concurrent ramp and shaft excavation also shorten the construction period with 18 months for the underground excavations. The discounted total cost is however 100 million Swedish Kronor higher for this

  18. Enthalpy screen of drug candidates.

    Science.gov (United States)

    Schön, Arne; Freire, Ernesto

    2016-11-15

    The enthalpic and entropic contributions to the binding affinity of drug candidates have been acknowledged to be important determinants of the quality of a drug molecule. These quantities, usually summarized in the thermodynamic signature, provide a rapid assessment of the forces that drive the binding of a ligand. Having access to the thermodynamic signature in the early stages of the drug discovery process will provide critical information towards the selection of the best drug candidates for development. In this paper, the Enthalpy Screen technique is presented. The enthalpy screen allows fast and accurate determination of the binding enthalpy for hundreds of ligands. As such, it appears to be ideally suited to aid in the ranking of the hundreds of hits that are usually identified after standard high throughput screening. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Leishmaniasis: vaccine candidates and perspectives.

    Science.gov (United States)

    Singh, Bhawana; Sundar, Shyam

    2012-06-06

    Leishmania is a protozoan parasite and a causative agent of the various clinical forms of leishmaniasis. High cost, resistance and toxic side effects of traditional drugs entail identification and development of therapeutic alternatives. The sound understanding of parasite biology is key for identifying novel drug targets, that can induce the cell mediated immunity (mainly CD4+ and CD8+ IFN-gamma mediated responses) polarized towards a Th1 response. These aspects are important in designing a new vaccine along with the consideration of the candidates with respect to their ability to raise memory response in order to improve the vaccine performance. This review is an effort to identify molecules according to their homology with the host and their ability to be used as potent vaccine candidates. Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

  20. Infographics: A new competency area for teacher candidates

    Directory of Open Access Journals (Sweden)

    Hakan Islamoglu

    2015-01-01

    Full Text Available Changes in technology have a growing influence on daily-life activities and the information-processing habits of individuals. As information and communication devices evolve to deliver richer content rapidly, regardless of time and place, new media presentation formats emerge. Infographics provide an example of such formats, and they have increased in popularity due mostly to their visual appeal and capacity to effectively present information. Infographics are also promising cognitive tools; however, their applications in educational practice are limited at best. Therefore, the aim of this study is to raise awareness about the opportunities that infographics provide for education and suggest ways to integrate infographics knowledge and skill development in teacher education. In line with that, first, a brief introduction to visual literacy is made. Then, infographics and their capacities for teaching and learning activities are discussed. Finally, as alternative ways for teacher education institutions and schools to offer infographics, training opportunities were proposed

  1. Toward organometallic antischistosomal drug candidates.

    Science.gov (United States)

    Hess, Jeannine; Keiser, Jennifer; Gasser, Gilles

    2015-01-01

    In the recent years, there has been a growing interest in the use of novel approaches for the treatment of parasitic diseases such as schistosomiasis. Among the different approaches used, organometallic compounds were found to offer unique opportunities in the design of antiparasitic drug candidates. A ferrocenyl derivative, namely ferroquine, has even entered clinical trials as a novel antimalarial. In this short review, we report on the studies describing the use of organometallic compounds against schistosomiasis.

  2. Candidates for office 2004-2006

    Science.gov (United States)

    Electronic polls for elections for 2004-2006 officers will open in early November 2003. In the 23 September issue of Eos, candidates' biographies and statements for Union Office and for four Sections were presented. Election material for candidates for the remaining Sections are presented here. All candidates' biographies and statements are on the Web at: http://www.agu.org/elections.

  3. Candidate worldviews for design theory

    DEFF Research Database (Denmark)

    Galle, Per

    2008-01-01

    Our growing body of design theory risks being infected by more inconsistency than is justifiable by genuine disagreement among design theorists. Taking my cue from C. S. Peirce, who argued that theory inevitably rests on basic metaphysical assumptions that theorists ought to be critically aware of......, I demonstrate how ‘insidious inconsistency’ may infect design theory if we ignore his admonition. As a possible remedy, I propose a method by which the philosophy of design may develop sound metaphysical foundations (‘worldviews’) for design theory – and generate philosophical insights into design...... at the same time. Examples are given of how the first steps of the method may be carried out and a number of candidate worldviews are outlined and briefly discussed. In its own way, each worldview answers certain fundamental questions about the nature of design. These include the ontological question of what...

  4. Hyper-Plurality of Candidates, Effectiveness of Democratic Representation and Regulation of Candidate Entry in India

    OpenAIRE

    Kaushik, Bhattacharya; Subrata K, Mitra

    2013-01-01

    The presence of large number of candidates in Indian elections had often evoked extremely strong policy recommendations from different expert groups. The major policy tool to control candidate entry in India had, however, been electoral deposit. Using panel data on elections in different states and UTs, our study estimates the impact of electoral deposit on candidate entry. Results suggest that increase in deposit had a substantial short-term negative impact on candidate entry. The candidate ...

  5. Low-pH injection grout for deep repositories. Summary report from a co-operation project between NUMO (Japan), Posiva (Finland) and SKB (Sweden)

    International Nuclear Information System (INIS)

    Boden, Anders; Sievaenen, Ursula

    2005-06-01

    experiments. 5. Fly ash system was ruled out at an early stage due to expected problems concerning the availability and stability of the raw material properties as well as expected difficulties with the setting time of the mixes. The grouting related properties tested in laboratory were penetrability, bleeding, early age shear strength viscosity and yield value. For some selected mixes fluidity was also measured. The key uncertainties identified with respect to the use of cement in a repository are related to the uncertainties in the estimation of the range and effect of the pH-plume on the rock, as well as the possible detrimental effects on bentonite due to cement/bentonite interaction. In the present study the potential effects on the repository performance and the rock have been evaluated based on the composition of the materials and leaching tests, expert judgement and some simple mass balance and diffusion calculations. A first review of the potential effects of organic cement additives on the radionuclide mobility has also been done, although the preference at the outset of the project was to develop an injection grout without organic additives. Also the long-term durability of the low-pH cementitious material and the long-term phase changes/degradation and leaching of the grout is not yet known and need to be evaluated. The non-cementitious candidate materials were investigated regarding basic properties and long-term safety aspects in order to form the basis for the decision whether silica sol can be used in the deep repository and whether periclase (MgO) should be further investigated. In a small field-test it was also investigated if the penetration of silica sol can be predicted based on hydraulic tests, transmissivity and hydraulic aperture. Silica sol, colloidal silica, is a stable dispersion of discrete non porous particles of amorphous silicon dioxide. Rock grouting with silica sol is a relatively new application. Colloidal silica seems to be a feasible

  6. Low-pH injection grout for deep repositories. Summary report from a co-operation project between NUMO (Japan), Posiva (Finland) and SKB (Sweden)

    Energy Technology Data Exchange (ETDEWEB)

    Boden, Anders [SwedPower AB, Stockholm (Sweden); Sievaenen, Ursula [JP-Suoraplan Oy, Vantaa (Finland)

    2005-06-01

    fineness, were modified in the present experiments. 5. Fly ash system was ruled out at an early stage due to expected problems concerning the availability and stability of the raw material properties as well as expected difficulties with the setting time of the mixes. The grouting related properties tested in laboratory were penetrability, bleeding, early age shear strength viscosity and yield value. For some selected mixes fluidity was also measured. The key uncertainties identified with respect to the use of cement in a repository are related to the uncertainties in the estimation of the range and effect of the pH-plume on the rock, as well as the possible detrimental effects on bentonite due to cement/bentonite interaction. In the present study the potential effects on the repository performance and the rock have been evaluated based on the composition of the materials and leaching tests, expert judgement and some simple mass balance and diffusion calculations. A first review of the potential effects of organic cement additives on the radionuclide mobility has also been done, although the preference at the outset of the project was to develop an injection grout without organic additives. Also the long-term durability of the low-pH cementitious material and the long-term phase changes/degradation and leaching of the grout is not yet known and need to be evaluated. The non-cementitious candidate materials were investigated regarding basic properties and long-term safety aspects in order to form the basis for the decision whether silica sol can be used in the deep repository and whether periclase (MgO) should be further investigated. In a small field-test it was also investigated if the penetration of silica sol can be predicted based on hydraulic tests, transmissivity and hydraulic aperture. Silica sol, colloidal silica, is a stable dispersion of discrete non porous particles of amorphous silicon dioxide. Rock grouting with silica sol is a relatively new application

  7. Preliminary site description Forsmark area - version 1.1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-03-01

    This report presents the interim version (model version 1.1) of the preliminary Site Descriptive Model for Forsmark. The basis for this interim version is quality-assured, geoscientific and ecological field data from Forsmark that were available in the SKB databases SICADA and GIS at April 30, 2003 as well as version 0 of the Site Descriptive Model. The new data acquired during the initial site investigation phase to the date of data freeze 1.1 constitute the basis for the updating of version 0 to version 1.1. These data originate from surface investigations on the candidate area with its regional environment and from drilling and investigations in boreholes. The surface-based data sets were rather extensive whereas the data sets from boreholes were limited to information from one 1,000 m deep cored borehole (KFM01A) and eight 150 to 200 m deep percussion-drilled boreholes in the Forsmark candidate area. Discipline specific models are developed for a selected regional and local model volume and these are then integrated into a site description. The current methodologies for developing the discipline specific models and the integration of these are documented in methodology reports or strategy reports. In the present work, the guidelines given in those reports were followed to the extent possible with the data and information available at the time for data freeze for model version 1.1. Compared with version 0 there are considerable additional features in the version 1.1, especially in the geological description and in the description of the near surface. The geological models of lithology and deformation zones are based on borehole information and much higher resolution surface data. The existence of highly fractured sub-horizontal zones has been verified and these are now part of the model of the deformation zones. A discrete fracture network (DFN) model has also been developed. The rock mechanics model is based on strength information from SFR and an empirical

  8. Preliminary site description Forsmark area - version 1.1

    International Nuclear Information System (INIS)

    2004-03-01

    This report presents the interim version (model version 1.1) of the preliminary Site Descriptive Model for Forsmark. The basis for this interim version is quality-assured, geoscientific and ecological field data from Forsmark that were available in the SKB databases SICADA and GIS at April 30, 2003 as well as version 0 of the Site Descriptive Model. The new data acquired during the initial site investigation phase to the date of data freeze 1.1 constitute the basis for the updating of version 0 to version 1.1. These data originate from surface investigations on the candidate area with its regional environment and from drilling and investigations in boreholes. The surface-based data sets were rather extensive whereas the data sets from boreholes were limited to information from one 1,000 m deep cored borehole (KFM01A) and eight 150 to 200 m deep percussion-drilled boreholes in the Forsmark candidate area. Discipline specific models are developed for a selected regional and local model volume and these are then integrated into a site description. The current methodologies for developing the discipline specific models and the integration of these are documented in methodology reports or strategy reports. In the present work, the guidelines given in those reports were followed to the extent possible with the data and information available at the time for data freeze for model version 1.1. Compared with version 0 there are considerable additional features in the version 1.1, especially in the geological description and in the description of the near surface. The geological models of lithology and deformation zones are based on borehole information and much higher resolution surface data. The existence of highly fractured sub-horizontal zones has been verified and these are now part of the model of the deformation zones. A discrete fracture network (DFN) model has also been developed. The rock mechanics model is based on strength information from SFR and an empirical

  9. Post-glacial faulting in the Lansjaerv area, Northern Sweden. Comments from the expert group on a field visit at the Molberget post-glacial fault area, 1991

    International Nuclear Information System (INIS)

    Stanfors, R.; Ericsson, L.O.

    1993-05-01

    Post-glacial faults have been recognized in the northern Baltic shield for several decades. It is important to evaluate whether such neotectonic movements can lead to new fracturing or decisively alter the geohydrological or geohydrochemical situation around a final repository for spent nuclear fuel. The post-glacial Lansjaerv fault was chosen for an interdisciplinary study because of its relative accessibility. The goals of the study were to assess the mechanisms that caused present day scraps, to clarify the extent of any recent fracturing and to clarify the extent of any ongoing movements. All these objectives were reasonably met through a series of studies, which have been performed by SKB during 1986-1992 in two phases. This report gives a summary of the first phase of the Lansjaerv study (1986-1989) and describes achievements that have been gained during the second phase of the study. As a final of the field-work in the Lansjaerv area a meeting combined with a field excursion was arranged by SKB in June 1991 for a group of international experts. Comments from the expert group on the excursion and the overall Lansjaerv project are presented. One of the major conclusions is that the Lansjaerv post-glacial fault reactivated pre-existing old structures and that the causes of the post-glacial movements is a combination of plate tectonics and deglaciation

  10. Comments from the Swedish Society for Nature Conservation, SSNC, and the Swedish NGO office for Nuclear Waste Review, MKG, on the industry's, SKB, research programme Fud-07

    International Nuclear Information System (INIS)

    2009-06-01

    to develop its own independent assessment tools and knowledge base for its assessment of the industry's presentation, in the forthcoming application documents, of alternative methods for storing high-level nuclear waste. - The Government needs to make it clear that both long-term environmental safety and the security risks that are imposed by possible deliberate or speculative violation of the repository poses weigh heavily in any evaluation of the various alternative methods for storage of high-level nuclear waste. - The Government must ensure that the Radiation Safety Authority continues to develop its own independent assessment tools and knowledge base for its evaluation of an inland location of the repository with respect to long term environmental safety. - The Government should alert the Radiation Safety Authority to the need to make sure that both collective radiation doses from diffuse sources and the impact of radiation on the entire eco-system are included in safety analyses. - The Government should make it clear to the industry, to local government and to other actors that long-term environmental safety is an overriding criterion that may not be compromised by hastening to a decision to establish a repository. - The Government should review and revise legislation in the area of radiation safety. - The Government should review and reorganize the administrative structure of social science research relating to nuclear waste management. - The Government should take measures to ensure that environmental organizations can receive funds out of the Swedish Nuclear Waste Fund also after 2008

  11. Do People 'Like' Candidates on Facebook?

    DEFF Research Database (Denmark)

    Nielsen, Rasmus Kleis

    The online popularity of a few exceptional candidates has led many to suggest that social media have given politicians powerful ways of communicating directly with voters. In this paper, we examine whether this is happening on a significant scale and show, based on analysis of 224 candidates invo...

  12. Trends in Teacher Candidates' Educational Beliefs.

    Science.gov (United States)

    Minor, Lynn C.; Onwuegbuzie, Anthony J.; Witcher, Ann E.; James, Terry L.

    This study examined trends in teacher candidates' educational beliefs over time. Participants were 84 teacher education candidates enrolled in several sections of an introductory-level education class for education majors at a southeastern university. They were administered the Witcher-Travers Survey of Educational Beliefs (WTSEB) both on the…

  13. A possible candidate for cold dark matter

    Indian Academy of Sciences (India)

    This additional scalar can be a viable candidate of cold dark matter (CDM) since the stability of is achieved by the application of Z 2 symmetry on . Considering as a possible candidate of CDM, Boltzmann's equation is solved to find the freeze-out temperature and relic density of for Higgs mass 120 GeV in the scalar ...

  14. 76 FR 36130 - Call for Candidates

    Science.gov (United States)

    2011-06-21

    ... FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Call for Candidates AGENCY: Federal Accounting... candidates. Any applicant who provided the Federal Accounting Standards Advisory Board (FASAB or the Board... to [email protected] ; by U.S. mail or commercial delivery service to: Federal Accounting Standards...

  15. ELECTIONS PENSION FUND CANDIDATE NR 1

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : CHIAVERI First Name : Enrico I have been a CERN staff member since 1973 and have always been interested in our working conditions. As a member of the Executive Committee of the Staff Association I participated from 1980 to 1984 in the Working Group on Pensions mandated by the CERN Council. This commitment led to my becoming a member of the Governing Board of the Pension Fund in 1983, since when I have taken an active part in various commissions and working groups (Real Estate Asset Management Committee, Working Group on Actuarial Matters etc.); in so doing I have gained a thorough knowledge of different areas of the Pension Fund. Since ...

  16. Undercover Stars Among Exoplanet Candidates

    Science.gov (United States)

    2005-03-01

    events by monitoring the brightness of a very large number of stars over extended time intervals. During the past years, it has also included a search for periodic, very shallow "dips" in the brightness of stars, caused by the regular transit of small orbiting objects (small stars, brown dwarfs [2] or Jupiter-size planets). The OGLE team has since announced 177 "planetary transit candidates" from their survey of several hundred thousand stars in three southern sky fields, one in the direction of the Galactic Centre, another within the Carina constellation and the third within the Centaurus/Musca constellations. The nature of the transiting object can however only be established by subsequent radial-velocity observations of the parent star. The size of the velocity variations (the amplitude) is directly related to the mass of the companion object and therefore allows discrimination between stars and planets as the cause of the observed brightness "dip". A Bonanza of Low-Mass Stars An international team of astronomers [3] has made use of the 8.2-m VLT Kueyen telescope for this work. Profiting from the multiplex capacity of the FLAMES/UVES facility that permits to obtain high-resolution spectra of up to 8 objects simultaneously, they have looked at 60 OGLE transit candidate stars, measuring their radial velocities with an accuracy of about 50 m/s [4]. This ambitious programme has so far resulted in the discovery of five new transiting exoplanets (see, e.g., ESO PR 11/04 for the announcement of two of those). Most of the other transit candidates identified by OGLE have turned out to be eclipsing binaries, that is, in most cases common, small and low-mass stars passing in front of a solar-like star. This additional wealth of data on small and light stars is a real bonanza for the astronomers. Constraining the Relation Between Mass and Radius Low-mass stars are exceptionally interesting objects, also because the physical conditions in their interiors have much in common with

  17. Aspirant candidate behaviour and progressive political ambition

    Directory of Open Access Journals (Sweden)

    Peter Allen

    2017-02-01

    Full Text Available In this paper we take account of the role of aspirant candidate behaviour in progressive political ambition, specifically how some individuals signal their political ambition to political actors by approaching them to discuss running for office. We examine how the effect of this behaviour compares to the more prominently studied effect of elite recruitment. We conclude that signalling behaviour by an aspirant candidate has a substantial effect, particularly with regard to actually acting on initial considerations of whether to stand, and that elite recruitment makes a difference but only in conjunction with the aspirant candidate themselves signalling their ambition to political actors.

  18. Candidate preferences and expectations of election outcomes

    Science.gov (United States)

    Delavande, Adeline; Manski, Charles F.

    2012-01-01

    Analysis of data from the American Life Panel shows that in the presidential election of 2008 and in multiple statewide elections in 2010, citizens exhibited large differences in their expectations of election outcomes. Expectations were strongly positively associated with candidate preferences, persons tending to believe that their preferred candidate is more likely to win the election. Committed supporters of opposing candidates regularly differed by 20–30% in their assessments of the likelihood that each candidate would win. These findings contribute evidence on the false consensus effect, the empirical regularity that own preferences tend to be positively associated with perceptions of social preferences. We used unique measures of preferences and perceptions that enabled respondents to express uncertainty flexibly. We studied a setting that would a priori seem inhospitable to false consensus—one where persons have little private information on social preferences but substantial common knowledge provided by media reports of election polls. PMID:22355121

  19. Candidate preferences and expectations of election outcomes.

    Science.gov (United States)

    Delavande, Adeline; Manski, Charles F

    2012-03-06

    Analysis of data from the American Life Panel shows that in the presidential election of 2008 and in multiple statewide elections in 2010, citizens exhibited large differences in their expectations of election outcomes. Expectations were strongly positively associated with candidate preferences, persons tending to believe that their preferred candidate is more likely to win the election. Committed supporters of opposing candidates regularly differed by 20-30% in their assessments of the likelihood that each candidate would win. These findings contribute evidence on the false consensus effect, the empirical regularity that own preferences tend to be positively associated with perceptions of social preferences. We used unique measures of preferences and perceptions that enabled respondents to express uncertainty flexibly. We studied a setting that would a priori seem inhospitable to false consensus--one where persons have little private information on social preferences but substantial common knowledge provided by media reports of election polls.

  20. Evaluating historical candidate genes for schizophrenia

    DEFF Research Database (Denmark)

    Farrell, M S; Werge, T; Sklar, P

    2015-01-01

    Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1). The initial study for 24...... of these genes explicitly evaluated common variant hypotheses about schizophrenia. Our evaluation included a meta-analysis of the candidate gene literature, incorporation of the results of the largest genomic study yet published for schizophrenia, ratings from informed researchers who have published...... on these genes, and ratings from 24 schizophrenia geneticists. On the basis of current empirical evidence and mostly consensual assessments of informed opinion, it appears that the historical candidate gene literature did not yield clear insights into the genetic basis of schizophrenia. A likely reason why...

  1. 76 FR 4896 - Call for Candidates

    Science.gov (United States)

    2011-01-27

    ... designated to establish generally accepted accounting principles for federal government entities. Generally, non-federal Board members are selected from the general financial community, the accounting and... FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Call for Candidates AGENCY: Federal Accounting...

  2. Characterization of nanoparticles as candidate reference materials

    International Nuclear Information System (INIS)

    Martins Ferreira, E.H.; Robertis, E. de; Landi, S.M.; Gouvea, C.P.; Archanjo, B.S.; Almeida, C.A.; Araujo, J.R. de; Kuznetsov, O.; Achete, C.A.

    2013-01-01

    We report the characterization of three different nanoparticles (silica, silver and multi-walled carbon nanotubes) as candidate reference material. We focus our analysis on the size distribution of those particles as measured by different microscopy techniques. (author)

  3. Cattle Candidate Genes for Milk Production Traits

    OpenAIRE

    KADLEC, Tomáš

    2012-01-01

    The aim of this thesis is to make an overview of important candidate genes affecting milk yield and milk quality parameters, with an emphasis on genes associated with the quantity and quality of milk proteins and milk fat.

  4. Vaccine candidates for malaria: what's new?

    Science.gov (United States)

    Takashima, Eizo; Morita, Masayuki; Tsuboi, Takafumi

    2016-01-01

    Although it is more than a decade since the parasite genome information was obtained, standardized novel genome-wide selection/prioritization strategies for candidacy of malaria vaccine antigens are still sought. In the quest to systematically identify candidates, it is impossible to overemphasize the usefulness of wheat germ cell-free technology in expressing quality proteins for the post-genome vaccine candidate discovery.

  5. Indico CONFERENCE: Candidate participant's registration/application

    CERN Multimedia

    CERN. Geneva; Ferreira, Pedro

    2017-01-01

    In this tutorial you are going to learn how to apply as a candidate participant (if the event requires approval from the event manager) or to register (if participation to the event doesn't require approval from an event manager) to the conference using the registration form for the event. You are also going to learn how to approve a candidate participant's application as an event manager.

  6. Studies of some IAEA candidate reference materials for microanalytical techniques

    International Nuclear Information System (INIS)

    Zhang Yuanxun; Qian Yine; Li Deyi; Wang Yinsong; Tan Mingguang; Wang Xuepeng; Gu Yingmei; Zhu Jieqing

    2002-01-01

    In order to develop new reference materials for microanalytical nuclear techniques, the Scanning Proton Microprobe (SPM) technique was used to determine homogeneity level within 100x200 μm 2 micro-area on the small pieces of IAEA Urban Dust reference materials. In part 1 of this paper, the experimental methods are described in detail. The results show that IAEA-396A/M Vienna Urban Dust is homogeneous enough for small sample analysis. As a task we prepared the IAEA-386 bovine liver as a new candidate reference material to meet this purpose. In part 2, the preparation process including material collection, dried, pulverize, sieve, homogenization and preliminary test is described in detail. The more effective grinding methods were established to achieve the median particle size of 22 μm. Also in part.3 we performed the qualitative determinations of some candidate reference materials by NAA and AFS. (author)

  7. National Vocational Qualifications: the candidates' experience.

    Science.gov (United States)

    Isaac, Susan

    2007-03-01

    To examine the experience of studying for an National Vocational Qualification (NVQ) by past and present candidates in the library and information science sector, their reasons for choosing this qualification and its impact on completion. Following a review of the literature, a number of NVQ candidates were interviewed using a semi-structured questionnaire. Candidates were contacted via e-mail through NVQ Centres and the LondonLinks e-mail list. There is a focus on health libraries as the flexibility and work-based nature of NVQs enable more staff to access training and education in this sector, despite the not uncommon low levels of staffing. NVQ Centres have gained experience since NVQs were launched 10 years ago. More support is offered to candidates and a number of issues such as isolation, are no longer a problem. An interesting result was the high number of candidates who had gone on to higher education following the completion of an NVQ. The NVQ is a useful method of providing staff with an opportunity to gain a recognized qualification. A significant number of candidates reported that the NVQ was ultimately a positive experience that improved their working practices. It can be an important first step for non-professional staff, but the future remains uncertain.

  8. Evaluation of a Heart Transplant Candidate.

    Science.gov (United States)

    Lee, Sook Jin; Kim, Kyung Hee; Hong, Suk Keun; Hankins, Shelley

    2017-11-04

    Heart transplantation is the best option for irreversible and critically advanced heart failure. However, limited donor pool, the risk of rejection, infection, and right ventricular dysfunction in short-term post-transplant period, as well as, the development of coronary allograft vasculopathy and malignancy in the long-term post-transplant period limits the utility of heart transplantation for all comers with advanced heart failure. Therefore, selection of appropriate candidates is very important for the best short and long-term prognosis. In this article, we discuss the principles of selection of candidates and compare to the recently updated International Society for Heart and Lung Transplantation (ISHLT) listing criteria with the goal of updating current clinical practice. We found that while most of the recommendations in the new listing criteria are continuous with the previous criteria, updated recommendations are made on the risk stratification models in choosing transplantation candidates. Recommendation on hepatic dysfunction is not directly included in the updated ISHLT listing criteria; however, adoption of the Model for End-stage Liver Disease (MELD) score and modified MELD scores in the evaluation of risk are suggested in recent studies. In conclusion, evaluation of patient selection for heart transplantation should be comprehensive and individualized with respect to indications and the risk of comorbidities of candidates. With the advancement of mechanical circulatory support (MCS), the selection of heart transplantation candidate is continuously evolving and widened. MCS as bridge to candidacy should be considered when the candidate has potentially reversible risk factors for transplantation.

  9. 11 CFR 9033.1 - Candidate and committee agreements.

    Science.gov (United States)

    2010-01-01

    ... candidate. (7) The candidate and the candidate's authorized committee(s) will permit an audit and... pursuant to 11 CFR part 9039. The candidate and authorized committee(s) shall facilitate the audit by... 11 Federal Elections 1 2010-01-01 2010-01-01 false Candidate and committee agreements. 9033.1...

  10. JELLYFISH GALAXY CANDIDATES AT LOW REDSHIFT

    Energy Technology Data Exchange (ETDEWEB)

    Poggianti, B. M.; Fasano, G.; Omizzolo, A.; Gullieuszik, M.; Bettoni, D.; Paccagnella, A. [INAF-Astronomical Observatory of Padova (Italy); Moretti, A.; D’Onofrio, M. [Physics and Astronomy Department, University of Padova (Italy); Jaffé, Y. L. [Department of Astronomy, Universidad de Concepción, Concepción (Chile); Vulcani, B. [Kavli Institute for the Physics and Mathematics of the universe (WPI), The University of Tokyo Institutes for Advanced Study (UTIAS), the University of Tokyo, Kashiwa, 277-8582 (Japan); Fritz, J. [Centro de Radioastronomía y Astrofísica, CRyA, UNAM, Michoacán (Mexico); Couch, W. [Australian Astronomical Observatory, North Ryde, NSW 1670 (Australia)

    2016-03-15

    Galaxies that are being stripped of their gas can sometimes be recognized from their optical appearance. Extreme examples of stripped galaxies are the so-called “jellyfish galaxies” that exhibit tentacles of debris material with a characteristic jellyfish morphology. We have conducted the first systematic search for galaxies that are being stripped of their gas at low-z (z = 0.04−0.07) in different environments, selecting galaxies with varying degrees of morphological evidence for stripping. We have visually inspected B- and V-band images and identified 344 candidates in 71 galaxy clusters of the OMEGAWINGS+WINGS sample and 75 candidates in groups and lower mass structures in the PM2GC sample. We present the atlas of stripping candidates and a first analysis of their environment and their basic properties, such as morphologies, star formation rates and galaxy stellar masses. Candidates are found in all clusters and at all clustercentric radii, and their number does not correlate with the cluster velocity dispersion σ or X-ray luminosity L{sub X}. Interestingly, convincing cases of candidates are also found in groups and lower mass halos (10{sup 11}−10{sup 14}M{sub ⊙}), although the physical mechanism at work needs to be securely identified. All the candidates are disky, have stellar masses ranging from log M/M{sub ⊙} < 9 to > 11.5 and the majority of them form stars at a rate that is on average a factor of 2 higher (2.5σ) compared to non-stripped galaxies of similar mass. The few post-starburst and passive candidates have weak stripping evidence. We conclude that disturbed morphologies suggestive of stripping phenomena are ubiquitous in clusters and could be present even in groups and low mass halos. Further studies will reveal the physics of the gas stripping and clarify the mechanisms at work.

  11. Data requirements and data sources for biodiversity priority area ...

    Indian Academy of Sciences (India)

    Unknown

    The data needed to prioritize areas for biodiversity protection are records of biodiversity features – species, species assemblages, environmental classes – for each candidate area. Prioritizing areas means comparing candidate areas, so the data used to make such comparisons should be comparable in quality and ...

  12. Scalar tetraquark candidates on the lattice

    International Nuclear Information System (INIS)

    Berlin, Joshua

    2017-01-01

    The topic of this thesis is the investigation of scalar tetraquark candidates from lattice QCD. It is motivated by a previous study originating in the twisted mass collaboration. The initial tetraquark candidate of choice is the a 0 (980), an isovector in the nonet of light scalars (J P =0 + ). This channel is still poorly understood. It displays an inverted mass hierarchy to what is expected from the conventional quark model and the a 0 (980) and f 0 (980) feature a surprising mass degeneracy. For this reasons the a 0 (980) is a long assumed tetraquark candidate in the literature. We follow a methodological approach by studying the sensitivity of the scalar spectrum with fully dynamical quarks to a large basis of two-quark and four-quark creation operators. Ultimately, the candidate has to be identified in the direct vicinity of two two-particles states, which is understandably inevitable for a tetraquark candidate. To succeed in this difficult task two-meson creation operators are essential to employ in this channel. By localized four-quark operators we intend to probe the Hamiltonian on eigenstates with a closely bound four-quark structure.

  13. Developing Potential Candidates of Preclinical Preeclampsia

    Science.gov (United States)

    Founds, Sandra; Zeng, Xuemei; Lykins, David; Roberts, James M.

    2015-01-01

    The potential for developing molecules of interest in preclinical preeclampsia from candidate genes that were discovered on gene expression microarray analysis has been challenged by limited access to additional first trimester trophoblast and decidual tissues. The question of whether these candidates encode secreted proteins that may be detected in maternal circulation early in pregnancy has been investigated using various proteomic methods. Pilot studies utilizing mass spectrometry based proteomic assays, along with enzyme linked immunosorbent assays (ELISAs), and Western immunoblotting in first trimester samples are reported. The novel targeted mass spectrometry methods led to robust multiple reaction monitoring assays. Despite detection of several candidates in early gestation, challenges persist. Future antibody-based studies may lead to a novel multiplex protein panel for screening or detection to prevent or mitigate preeclampsia. PMID:26580600

  14. Developing Potential Candidates of Preclinical Preeclampsia

    Directory of Open Access Journals (Sweden)

    Sandra Founds

    2015-11-01

    Full Text Available The potential for developing molecules of interest in preclinical preeclampsia from candidate genes that were discovered on gene expression microarray analysis has been challenged by limited access to additional first trimester trophoblast and decidual tissues. The question of whether these candidates encode secreted proteins that may be detected in maternal circulation early in pregnancy has been investigated using various proteomic methods. Pilot studies utilizing mass spectrometry based proteomic assays, along with enzyme linked immunosorbent assays (ELISAs, and Western immunoblotting in first trimester samples are reported. The novel targeted mass spectrometry methods led to robust multiple reaction monitoring assays. Despite detection of several candidates in early gestation, challenges persist. Future antibody-based studies may lead to a novel multiplex protein panel for screening or detection to prevent or mitigate preeclampsia.

  15. Environmental Systems Research Candidates FY-01 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Miller, David Lynn; Piet, Steven James

    2001-03-01

    The Environmental Systems Research Candidates (ESRC) Program ran from April 2000 through September 2001 as part of the Environmental Systems Research and Analysis (ESRA) Program at the Idaho National Engineering and Environmental Laboratory (INEEL). ESRA provides key science and technology to meet the cleanup mission of the U.S. Department of Energy Office of Environmental Management (EM), and performs research and development that will help solve current legacy problems and enhance the INEEL’s scientific and technical capability for solving longer-term challenges. This report documents the accomplishments of the ESRC Program. The ESRC Program consisted of 25 tasks subdivided within four research areas.

  16. Lost Near-Earth Object Candidates

    Science.gov (United States)

    Veres, Peter; Farnocchia, Davide; Williams, Gareth; Keys, Sonia; Boardman, Ian; Holman, Matthew J.; Payne, Matthew J.

    2017-10-01

    The number of discovered Near-Earth Objects (NEOs) increases rapidly, currently exceeding 16,000 NEOs. 2016 was the most productive year ever with 1,888 NEO discoveries. The NEO discovery process typically begins with three to five detections of a previously unidentified object that are reported to the Minor Planet Center (MPC). According to the plane-of-sky motion, the MPC ranks all of the new candidate discoveries for the likelihood of being NEOs using the so-called digest score. If the digest score is greater than 65 the observations appear on the publicly accessible NEO Confirmation Page (NEOCP). Objects on the NEOCP are followed up in subsequent hours and days. When enough observations are collected to ensure that the object is real and that the orbit is determined, the NEO is officially announced with its new designation by a Minor Planet Electronic Circular. However, 14% of NEO candidates never get confirmed and are therefore lost due to the lack of follow-up observations. We analyzed the lost NEO candidates that appeared on NEOCP in 2013-2016 and investigated the reasons why they were not confirmed. In particular, we studied the properties of the lost NEO candidates with a digest score of 100 that were reported by the two most prolific discovery sites - Pan-STARRS1 (F51) and Mt. Lemmon Survey (G96). We derived their plane-of-sky positions and rates, brightness, and ephemeris uncertainties, and assessed correlations with the phase of the moon and seasonal effects apparent in the given observatory’s data. We concluded that lost NEO candidates typically have a larger rate of motion and larger uncertainties than those of confirmed objects. However, many of the lost candidates could be recovered. In fact, the 1-sigma plane-of-sky uncertainty was still within ±0.5 deg in 79% (F51) and 69% (G96) of the cases 24 hours after discovery and in 31% (F51) and 30% (G96) of the cases 48 hours after discovery. If all of the NEO candidates with a digest score of 100 had

  17. Issue-Advocacy versus Candidate Advertising: Effects on Candidate Preferences and Democratic Process.

    Science.gov (United States)

    Pfau, Michael; Holbert, R. Lance; Szabo, Erin Alison; Kaminski, Kelly

    2002-01-01

    Examines the influence of soft-money-sponsored issue-advocacy advertising in U.S. House and Senate campaigns, comparing its effects against candidate-sponsored positive advertising and contrast advertising on viewers' candidate preferences and on their attitude that reflect democratic values. Reveals no main effects for advertising approach on…

  18. Soils and site types in the Forsmark area

    International Nuclear Information System (INIS)

    Lundin, Lars; Lode, Elve; Stendahl, Johan; Melkerud, Per-Arne; Bjoerkvald, Louise; Thorstensson, Anna

    2004-01-01

    Investigations to give prerequisites for long-term storage of nuclear waste are made by the Swedish Nuclear Fuel and Waste Management Company (SKB AB). Ecosystem functions are crucial in this management. The range of the scope is wide including bedrock, regolith, hydrosphere and biosphere. The interface between deep geological formations and surface systems is then considered very important. This would be the top of the regolith, where soils are developed. Special attention has been paid to these layers with fairly comprehensive investigations. Field investigations were made for one of the candidate areas, the Forsmark area, in 2002 by the Department of Forest Soils, Swedish University of Agricultural Sciences. In these ecosystem functions, the upper part of the regolith is one crucial component and the focus in the investigations was on the upper metre of the soil. Variables determined include vegetation, hydrology, soil parent material, textural composition, soil type and physical and chemical properties of relevant soil layers. Methods used in the investigation coincide with those of the Swedish Forest Soil Inventory, which provide possibilities to compare properties in the Forsmark area with those of total Sweden and regions of the country. Soil properties were determined thoroughly on eight site types in two replicates to provide statistical significance. However, this meant that the investigation did not have a total spatial coverage. Instead, the spatial distribution of soils in the area was determined from a GIS based on the inventory made and information on vegetation types, distribution of Quaternary deposits and a hydrological index. From this GIS, distributions were compared with other parts of the country. The geographical location of the Forsmark area (N 60 deg 22 min; E 18 deg 13 min) is on the northeast coast of central Sweden bordering to the Bothnian Sea. The area is low-lying, reaching only up to 15 m above the sea, which means that the soils are

  19. Implementing College and Career Standards in Math Methods Course for Early Childhood and Elementary Education Teacher Candidates

    Science.gov (United States)

    Lee, Joohi

    2016-01-01

    This study is purposed to measure the efficacy of implementing College and Career Readiness Standards (CCRS) math standards into math methods courses for early childhood and elementary education teacher candidates at an urban university located in the Dallas and Fort Worth metroplex area. A total of 161 college seniors (teacher candidates)…

  20. Dancing on Thin Ice: The Journey of Two Male Teacher Candidates Emerging as Professionals within a Teacher Education Dance Program

    Science.gov (United States)

    Kalyn, Brenda; Campbell, Eric; McAvoy, Alekcei; Weimer, Michelle

    2015-01-01

    Teacher candidates entering the world of curricula face the realities of teaching a variety of subjects, some more conceptually foreign than others. One challenging area for teacher candidates, particularly males, is in dance education (Gard, 2008; Kiley, 2010). A teacher's former dance experience, beliefs about who dances and why, personal…

  1. Enhancing Advocacy Skills of Teacher Candidates

    Science.gov (United States)

    Holmes, Melissa A.; Herrera, Socorro G.

    2009-01-01

    This case study explores the dynamics of enhancing the capacities of teacher candidates in the Bilingual/Bicultural Education Students Interacting to Obtain Success (BESITOS) recruitment and retention program to advocate for culturally and linguistically diverse (CLD) students. Herrera and Murry's advocacy framework provides the theoretical…

  2. 1998 astronaut candidates tour KSC facilities

    Science.gov (United States)

    1999-01-01

    On the grounds of the Kennedy Space Center, members of the 1998 astronaut candidate class (Group 17) watch as candidate Tracy E. Caldwell (Ph.D.) practices using firefighting equipment during fire training. The class is at KSC for training activities, including a flight awareness program, plus touring the OPF, VAB, SSPF, SSME Processing Facility, launch pads, SLF, Apollo/Saturn V Center, and the crew quarters. The other U.S. candidates in the '98 class are Clayton C. Anderson, Lee J. Archambault, Gregory E. Chamitoff (Ph.D.), Timothy J. Creamer, Christopher J. Ferguson, Michael J. Foreman, Michael E. Fossum, Kenneth T. Ham, Patricia C. Hilliard (M.D.), Gregory C. Johnson, Gregory H. Johnson, Stanley G. Love (Ph.D.), Leland D. Melvin, Barbara R. Morgan, William A. Oefelein, John D. Olivas (Ph.D.), Nicholas J.M. Patrick (Ph.D.), Alan G. Poindexter, Garrett E. Reisman (Ph.D.), Steven R. Swanson, Douglas H. Wheelock, Sunita L. Williams, Neil W. Woodward III, George D. Zamka; and the international candidates are Leopold Eyharts, Paolo Nespoli, Hans Schlegel, Roberto Vittori, Bjarni V. Tryggvason, and Marcos Pontes.

  3. Promoting Team Leadership Skills in Doctoral Candidates

    Science.gov (United States)

    Suleiman, Mahmoud; Whetton, Danny

    2014-01-01

    Doctoral programs can serve as an optimal opportunity for candidates to engage in tasks and activities to transform them and their schools. The paradigm shifts in such preparation involve moving from sitting and getting to making and taking. Most importantly, it requires building leadership skills and styles necessary to bring about desired change…

  4. Gallium-67 imaging in candidal esophagitis

    Energy Technology Data Exchange (ETDEWEB)

    Rundback, J.H.; Goldfarb, C.R.; Ongseng, F. (Beth Israel Medical Center, New York, NY (USA))

    1990-01-01

    Ga-67 scanning has been used to evaluate esophageal carcinoma. It has demonstrated candidal infection in other body sites and, in one previous case, in the esophagus. The authors present a case of diffuse esophageal uptake of Ga-67 in esophageal candidiasis.

  5. Gallium-67 imaging in candidal esophagitis

    International Nuclear Information System (INIS)

    Rundback, J.H.; Goldfarb, C.R.; Ongseng, F.

    1990-01-01

    Ga-67 scanning has been used to evaluate esophageal carcinoma. It has demonstrated candidal infection in other body sites and, in one previous case, in the esophagus. The authors present a case of diffuse esophageal uptake of Ga-67 in esophageal candidiasis

  6. Microlensing Binaries with Candidate Brown Dwarf Companions

    DEFF Research Database (Denmark)

    Shin, I.-G; Han, C.; Gould, A.

    2012-01-01

    Brown dwarfs are important objects because they may provide a missing link between stars and planets, two populations that have dramatically different formation histories. In this paper, we present the candidate binaries with brown dwarf companions that are found by analyzing binary microlensing...... with well-covered light curves increases with new-generation searches....

  7. Fuzzy Treatment of Candidate Outliers in Measurements

    Directory of Open Access Journals (Sweden)

    Giampaolo E. D'Errico

    2012-01-01

    Full Text Available Robustness against the possible occurrence of outlying observations is critical to the performance of a measurement process. Open questions relevant to statistical testing for candidate outliers are reviewed. A novel fuzzy logic approach is developed and exemplified in a metrology context. A simulation procedure is presented and discussed by comparing fuzzy versus probabilistic models.

  8. Query by image example: The CANDID approach

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, P.M.; Cannon, M. [Los Alamos National Lab., NM (United States). Computer Research and Applications Group; Hush, D.R. [Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Electrical and Computer Engineering

    1995-02-01

    CANDID (Comparison Algorithm for Navigating Digital Image Databases) was developed to enable content-based retrieval of digital imagery from large databases using a query-by-example methodology. A user provides an example image to the system, and images in the database that are similar to that example are retrieved. The development of CANDID was inspired by the N-gram approach to document fingerprinting, where a ``global signature`` is computed for every document in a database and these signatures are compared to one another to determine the similarity between any two documents. CANDID computes a global signature for every image in a database, where the signature is derived from various image features such as localized texture, shape, or color information. A distance between probability density functions of feature vectors is then used to compare signatures. In this paper, the authors present CANDID and highlight two results from their current research: subtracting a ``background`` signature from every signature in a database in an attempt to improve system performance when using inner-product similarity measures, and visualizing the contribution of individual pixels in the matching process. These ideas are applicable to any histogram-based comparison technique.

  9. Transiently expressed pattern during myogenesis and candidate ...

    Indian Academy of Sciences (India)

    Navya

    useful information about this gene and its candidate miRNAs in goose. Key words: Tmem8C, Myoblast ... proliferation and cell growth by controlling the G(1)- to S-phase transition in the cell cycle, and reducing the hyperplasia of .... architecture retrieval tool of BLAST (http://www.ncbi.nlm.nih.gov/BLAST). SignalP3.0 server.

  10. Tribological Tuft Testing Candidate Brush Seal Materials

    Science.gov (United States)

    DellaCorte, Chris

    1999-01-01

    This paper presents a tribological tuft test method of candidate brush seal materials in viewgraph form. The goals of the research are: 1) To develop test method to tribologically brush seal materials; 2) To evaluate materials to identify potential improvements and trends; and 3) Guide seal material development and selection.

  11. Shortlisted candidates for Accounts / Admin Assistant

    Indian Academy of Sciences (India)

    user

    Indian Academy of Sciences. Bengaluru. The following shortlisted candidates have been sent call letters for written test to be held on Friday, 29th January 2016 at Academy Office, Sadashivanagar, Bengaluru. ADMINISTRATIVE ASSISTANT. (29 January 2016, 9:30 – 11:00 a.m.). ACCOUNTS ASSISTANT. (29 January 2016 ...

  12. Optical observations of southern planetary nebula candidates

    NARCIS (Netherlands)

    VandeSteene, GC; Sahu, KC; Pottasch, [No Value

    1996-01-01

    We present H alpha+[NII] images and low resolution spectra of 16 IRAS-selected, southern planetary nebula candidates previously detected in the radio continuum. The H alpha+[NII] images are presented as finding charts. Contour plots are shown for the resolved planetary nebulae. From these images

  13. Soils and site types in the Forsmark area

    Energy Technology Data Exchange (ETDEWEB)

    Lundin, Lars; Lode, Elve; Stendahl, Johan; Melkerud, Per-Arne; Bjoerkvald, Louise; Thorstensson, Anna [Swedish Univ. of Agricultural Sciences, Uppsala (Sweden). Dept. of Forest Soils

    2004-01-01

    Investigations to give prerequisites for long-term storage of nuclear waste are made by the Swedish Nuclear Fuel and Waste Management Company (SKB AB). Ecosystem functions are crucial in this management. The range of the scope is wide including bedrock, regolith, hydrosphere and biosphere. The interface between deep geological formations and surface systems is then considered very important. This would be the top of the regolith, where soils are developed. Special attention has been paid to these layers with fairly comprehensive investigations. Field investigations were made for one of the candidate areas, the Forsmark area, in 2002 by the Department of Forest Soils, Swedish University of Agricultural Sciences. In these ecosystem functions, the upper part of the regolith is one crucial component and the focus in the investigations was on the upper metre of the soil. Variables determined include vegetation, hydrology, soil parent material, textural composition, soil type and physical and chemical properties of relevant soil layers. Methods used in the investigation coincide with those of the Swedish Forest Soil Inventory, which provide possibilities to compare properties in the Forsmark area with those of total Sweden and regions of the country. Soil properties were determined thoroughly on eight site types in two replicates to provide statistical significance. However, this meant that the investigation did not have a total spatial coverage. Instead, the spatial distribution of soils in the area was determined from a GIS based on the inventory made and information on vegetation types, distribution of Quaternary deposits and a hydrological index. From this GIS, distributions were compared with other parts of the country. The geographical location of the Forsmark area (N 60 deg 22 min; E 18 deg 13 min) is on the northeast coast of central Sweden bordering to the Bothnian Sea. The area is low-lying, reaching only up to 15 m above the sea, which means that the soils are

  14. A method of searching for supernova candidates from massive galaxy spectra

    Science.gov (United States)

    Tu, Liangping; Luo, Ali; Wu, Fuchao; Zhao, Yongheng

    2010-10-01

    This paper presents a novel spectroscopic method for searching for supernova candidates from massive galaxy spectra, which is expected to be applied to the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST). This method includes mainly five steps. The first step is spectral preprocessing, including removing spectral noise using wavelet transform, spectral de-redshift, etc. The second step is decomposition of galactic spectra; we can get the galaxy component and supernova component and calculate the Supernova Statistical Characterization Vector (SNSCV) of each galaxy spectrum. The third step is to decrease samples in all the galaxy spectral datasets according to SNSCV of each spectrum, and to use the LOF (Local Outlier Factor)-based outlier detection algorithm to obtain the preliminary selected spectral data. The fourth step is template matching by cross-correlation, according to the matched results we get the secondary selected spectral data. Finally, we choose the final supernova candidates manually through checking the spectral features characteristic of a supernova. By the spectroscopic method proposed in this paper, thirty-six supernova candidates have been detected in a dataset including 294843 galaxy spectra from the Sloan Digital Sky Survey Data Release 7. Nine of these objects are detected first and the other twenty-seven have been reported in other publications (fifteen of which are detected and reported first by us). The twenty-four new super-nova candidates include twenty la type supernova candidates, three Ic type supernova candidates and one II type supernova candidate.

  15. Preliminary safety evaluation for the Forsmark area. Based on data and site descriptions after the initial site investigation stage

    International Nuclear Information System (INIS)

    Andersson, Johan

    2005-08-01

    The main objectives of this Preliminary Safety Evaluation (PSE) of the Forsmark area have been to determine, with limited efforts, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the actual site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site-specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The evaluation shows that, even considering remaining uncertainties, the Forsmark area meets all stated safety requirements and preferences. Consequently, from a safety point of view, there is no reason not to continue the Site Investigations of the Forsmark area. There are still uncertainties to resolve and the safety would eventually need to be verified through a full safety assessment. Nevertheless, this Preliminary Safety Evaluation demonstrates that it is likely that a safe repository for spent nuclear fuel of the KBS-3 type could be constructed at the site. The following feedback is provided to the site investigations and the associated site modelling: Reducing the uncertainty on the deformation zone geometry inside the target area would be needed to more firmly define locations of the suitable deposition volumes. There is substantial uncertainty in the Discrete Fracture Network model. Further reduction of the uncertainties, if needed, would probably only be possible from the underground, detailed investigation phase. Efforts need also be spent on improving the DFN-modelling. There are assumptions made in current models that could be challenged and there seems to be room for better use of the borehole information. It is particularly important to provide

  16. Regional hydrogeological simulations for Forsmark - numerical modelling using CONNECTFLOW. Preliminary site description Forsmark area - version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Hartley, Lee; Cox, Ian; Hunter, Fiona; Jackson, Peter; Joyce, Steve; Swift, Ben [Serco Assurance, Risley (United Kingdom); Gylling, Bjoern; Marsic, Niko [Kemakta Konsult AB, Stockholm (Sweden)

    2005-05-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) carries out site investigations in two different candidate areas in Sweden with the objective of describing the in-situ conditions for a bedrock repository for spent nuclear fuel. The site characterisation work is divided into two phases, an initial site investigation phase (IPLU) and a complete site investigation phase (KPLU). The results of IPLU are used as a basis for deciding on a subsequent KPLU phase. On the basis of the KPLU investigations a decision is made as to whether detailed characterisation will be performed (including sinking of a shaft). An integrated component in the site characterisation work is the development of site descriptive models. These comprise basic models in three dimensions with an accompanying text description. Central in the modelling work is the geological model, which provides the geometrical context in terms of a model of deformation zones and the rock mass between the zones. Using the geological and geometrical description models as a basis, descriptive models for other geo-disciplines (hydrogeology, hydro-geochemistry, rock mechanics, thermal properties and transport properties) will be developed. Great care is taken to arrive at a general consistency in the description of the various models and assessment of uncertainty and possible needs of alternative models. Here, a numerical model is developed on a regional-scale (hundreds of square kilometres) to understand the zone of influence for groundwater flow that affects the Forsmark area. Transport calculations are then performed by particle tracking from a local-scale release area (a few square kilometres) to identify potential discharge areas for the site and using greater grid resolution. The main objective of this study is to support the development of a preliminary Site Description of the Forsmark area on a regional-scale based on the available data of 30 June 2004 and the previous Site Description. A more specific

  17. Spectroscopic follow up of Kepler planet candidates

    DEFF Research Database (Denmark)

    Latham..[], D. W.; Cochran, W. D.; Marcy, G.W.

    2010-01-01

    and not planets, our strategy is to start with reconnaissance spectroscopy using smaller telescopes, to sort out and reject as many of the false positives as possible before going to Keck. During the first Kepler observing season in 2009, more than 100 nights of telescope time were allocated for this work, using......Spectroscopic follow-up observations play a crucial role in the confirmation and characterization of transiting planet candidates identified by Kepler. The most challenging part of this work is the determination of radial velocities with a precision approaching 1 m/s in order to derive masses from...... spectroscopic orbits. The most precious resource for this work is HIRES on Keck I, to be joined by HARPS-North on the William Herschel Telescope when that new spectrometer comes on line in two years. Because a large fraction of the planet candidates are in fact stellar systems involving eclipsing stars...

  18. Spectroscopic follow up of Kepler planet candidates

    DEFF Research Database (Denmark)

    Latham..[], D. W.; Cochran, W. D.; Marcy, G.W.

    2010-01-01

    Spectroscopic follow-up observations play a crucial role in the confirmation and characterization of transiting planet candidates identified by Kepler. The most challenging part of this work is the determination of radial velocities with a precision approaching 1 m/s in order to derive masses from...... spectroscopic orbits. The most precious resource for this work is HIRES on Keck I, to be joined by HARPS-North on the William Herschel Telescope when that new spectrometer comes on line in two years. Because a large fraction of the planet candidates are in fact stellar systems involving eclipsing stars...... and not planets, our strategy is to start with reconnaissance spectroscopy using smaller telescopes, to sort out and reject as many of the false positives as possible before going to Keck. During the first Kepler observing season in 2009, more than 100 nights of telescope time were allocated for this work, using...

  19. Caffeine Consumption Among Naval Aviation Candidates.

    Science.gov (United States)

    Sather, Thomas E; Williams, Ronald D; Delorey, Donald R; Woolsey, Conrad L

    2017-04-01

    Education frequently dictates students need to study for prolonged periods of time to adequately prepare for examinations. This is especially true with aviation preflight indoctrination (API) candidates who have to assimilate large volumes of information in a limited amount of time during API training. The purpose of this study was to assess caffeine consumption patterns (frequency, type, and volume) among naval aviation candidates attending API to determine the most frequently consumed caffeinated beverage and to examine if the consumption of a nonenergy drink caffeinated beverage was related to energy drink consumption. Data were collected by means of an anonymous 44-item survey administered and completed by 302 students enrolled in API at Naval Air Station Pensacola, FL. Results indicated the most frequently consumed caffeinated beverage consumed by API students was coffee (86.4%), with daily coffee consumption being approximately 28% and the most frequent pattern of consumption being 2 cups per day (85%). The least frequently consumed caffeinated beverages reported were energy drinks (52%) and energy shots (29.1%). The present study also found that the consumption patterns (weekly and daily) of caffeinated beverages (coffee and cola) were positively correlated to energy drink consumption patterns. Naval aviation candidates' consumption of caffeinated beverages is comparable to other college and high school cohorts. This study found that coffee and colas were the beverages of choice, with energy drinks and energy shots being the least frequently reported caffeinated beverages used. Additionally, a relationship between the consumption of caffeinated beverages and energy drinks was identified.Sather TE, Williams RD, Delorey DR, Woolsey CL. Caffeine consumption among naval aviation candidates. Aerosp Med Hum Perform. 2017; 88(4):399-405.

  20. Candidates for non-baryonic dark matter

    OpenAIRE

    Fornengo, Nicolao

    2002-01-01

    This report is a brief review of the efforts to explain the nature of non-baryonic dark matter and of the studies devoted to the search for relic particles. Among the different dark matter candidates, special attention is devoted to relic neutralinos, by giving an overview of the recent calculations of its relic abundance and detection rates in a wide variety of supersymmetric schemes.

  1. Educational intervention for liver transplantation candidates

    OpenAIRE

    Mendes,Karina Dal Sasso; Silva Junior,Orlando de Castro e; Ziviani,Luciana da Costa; Rossin,Fabiana Murad; Zago,Márcia Maria Fontão; Galvão,Cristina Maria

    2013-01-01

    OBJECTIVE: The objective in this study was to analyze candidates' knowledge on the liver transplantation process before and after putting in practice an educational intervention. METHOD: A quasi-experimental, one-group pretest-posttest research design was adopted. The final sample included 15 subjects. Research data were collected between January and March 2010 in three phases, which were: pretest, implementation of the educational intervention (two meetings) and posttest. RESULTS: The result...

  2. Nutritional Status of Bariatric Surgery Candidates

    OpenAIRE

    Aliaa Al-Mutawa; Alfred Kojo Anderson; Salman Alsabah; Mohammad Al-Mutawa

    2018-01-01

    Obesity is a global epidemic affecting populations globally. Bariatric surgery is an effective treatment for morbid obesity, and has increased dramatically. Bariatric surgery candidates frequently have pre-existing nutritional deficiencies that might exacerbate post-surgery. To provide better health care management pre- and post-bariatric surgery, it is imperative to establish the nutritional status of prospective patients before surgery. The aim of this study was to assess and provide baseli...

  3. 1998 astronaut candidates tour CCAS facilities

    Science.gov (United States)

    1999-01-01

    At Cape Canaveral Air Station, members of the 1998 astronaut candidate class (Group 17) pose in front of the Project Mercury monument at Launch Complex 14 during a tour of the station's facilities. This 13-foot-high astronomical symbol for the planet Mercury was constructed by General Dynamics, the Atlas airframe contractor, and dedicated in 1964 in honor of those who flew in the Mercury 7 capsule. The class is at Kennedy Space Center taking part in training activities, including a flight awareness program, as well as touring the OPF, VAB, SSPF, SSME Processing Facility, launch pads, SLF, Apollo/Saturn V Center, and the crew quarters. The U.S. candidates in the '98 class are Clayton C. Anderson, Lee J. Archambault, Tracy E. Caldwell (Ph.D.), Gregory E. Chamitoff (Ph.D.), Timothy J. Creamer, Christopher J. Ferguson, Michael J. Foreman, Michael E. Fossum, Kenneth T. Ham, Patricia C. Hilliard (M.D.), Gregory C. Johnson, Gregory H. Johnson, Stanley G. Love (Ph.D.), Leland D. Melvin, Barbara R. Morgan, William A. Oefelein, John D. Olivas (Ph.D.), Nicholas J.M. Patrick (Ph.D.), Alan G. Poindexter, Garrett E. Reisman (Ph.D.), Steven R. Swanson, Douglas H. Wheelock, Sunita L. Williams, Neil W. Woodward III, George D. Zamka; and the international candidates are Leopold Eyharts, Paolo Nespoli, Hans Schlegel, Roberto Vittori, Bjarni V. Tryggvason, and Marcos Pontes.

  4. Nuclear safety in EU candidate countries

    International Nuclear Information System (INIS)

    2000-10-01

    Nuclear safety in the candidate countries to the European Union is a major issue that needs to be addressed in the framework of the enlargement process. Therefore WENRA members considered it was their duty to offer their technical assistance to their Governments and the European Union Institutions. They decided to express their collective opinion on nuclear safety in those candidate countries having at least one nuclear power plant: Bulgaria, the Czech Republic, Hungary, Lithuania, Romania, Slovakia and Slovenia. The report is structured as follows: A foreword including background information, structure of the report and the methodology used, General conclusions of WENRA members reflecting their collective opinion, For each candidate country, an executive summary, a chapter on the status of the regulatory regime and regulatory body, and a chapter on the nuclear power plant safety status. Two annexes are added to address the generic safety characteristics and safety issues for RBMK and VVER plants. The report does not cover radiation protection and decommissioning issues, while safety aspects of spent fuel and radioactive waste management are only covered as regards on-site provisions. In order to produce this report, WENRA used different means: For the chapters on the regulatory regimes and regulatory bodies, experts from WENRA did the work. For the chapters on nuclear power plant safety status, experts from WENRA and from French and German technical support organisations did the work. Taking into account the contents of these chapters, WENRA has formulated its general conclusions in this report

  5. Nuclear safety in EU candidate countries

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    Nuclear safety in the candidate countries to the European Union is a major issue that needs to be addressed in the framework of the enlargement process. Therefore WENRA members considered it was their duty to offer their technical assistance to their Governments and the European Union Institutions. They decided to express their collective opinion on nuclear safety in those candidate countries having at least one nuclear power plant: Bulgaria, the Czech Republic, Hungary, Lithuania, Romania, Slovakia and Slovenia. The report is structured as follows: A foreword including background information, structure of the report and the methodology used, General conclusions of WENRA members reflecting their collective opinion, For each candidate country, an executive summary, a chapter on the status of the regulatory regime and regulatory body, and a chapter on the nuclear power plant safety status. Two annexes are added to address the generic safety characteristics and safety issues for RBMK and VVER plants. The report does not cover radiation protection and decommissioning issues, while safety aspects of spent fuel and radioactive waste management are only covered as regards on-site provisions. In order to produce this report, WENRA used different means: For the chapters on the regulatory regimes and regulatory bodies, experts from WENRA did the work. For the chapters on nuclear power plant safety status, experts from WENRA and from French and German technical support organisations did the work. Taking into account the contents of these chapters, WENRA has formulated its general conclusions in this report.

  6. UNCOVERING THE NUCLEUS CANDIDATE FOR NGC 253

    Energy Technology Data Exchange (ETDEWEB)

    Günthardt, G. I.; Camperi, J. A. [Observatorio Astronómico, Universidad Nacional de Córdoba (Argentina); Agüero, M. P. [Observatorio Astronómico, Universidad Nacional de Córdoba, and CONICET (Argentina); Díaz, R. J.; Gomez, P. L.; Schirmer, M. [Gemini Observatory, AURA (United States); Bosch, G., E-mail: gunth@oac.uncor.edu, E-mail: camperi@oac.uncor.edu, E-mail: mpaguero@oac.uncor.edu, E-mail: rdiaz@gemini.edu, E-mail: pgomez@gemini.edu, E-mail: mschirmer@gemini.edu, E-mail: guille@fcaglp.unlp.edu.ar [Instituto de Astrofísica de La Plata (CONICET-UNLP) (Argentina)

    2015-11-15

    NGC 253 is the nearest spiral galaxy with a nuclear starburst that becomes the best candidate for studying the relationship between starburst and active galactic nucleus activity. However, this central region is veiled by large amounts of dust, and it has been so far unclear which is the true dynamical nucleus to the point that there is no strong evidence that the galaxy harbors a supermassive black hole co-evolving with the starburst as was supposed earlier. Near-infrared (NIR) spectroscopy, especially NIR emission line analysis, could be advantageous in shedding light on the true nucleus identity. Using Flamingos-2 at Gemini South we have taken deep K-band spectra along the major axis of the central structure and through the brightest infrared source. In this work, we present evidence showing that the brightest NIR and mid-infrared source in the central region, already known as radio source TH7 and so far considered just a large stellar supercluster, in fact presents various symptoms of a genuine galactic nucleus. Therefore, it should be considered a valid nucleus candidate. Mentioning some distinctive aspects, it is the most massive compact infrared object in the central region, located at 2.″0 of the symmetry center of the galactic bar, as measured in the K-band emission. Moreover, our data indicate that this object is surrounded by a large circumnuclear stellar disk and it is also located at the rotation center of the large molecular gas disk of NGC 253. Furthermore, a kinematic residual appears in the H{sub 2} rotation curve with a sinusoidal shape consistent with an outflow centered in the candidate nucleus position. The maximum outflow velocity is located about 14 pc from TH7, which is consistent with the radius of a shell detected around the nucleus candidate, observed at 18.3 μm (Qa) and 12.8 μm ([Ne ii]) with T-ReCS. Also, the Brγ emission line profile shows a pronounced blueshift and this emission line also has the highest equivalent width at this

  7. Potential Habitable Zone Exomoon Candidates and Radial Velocity Estimates for Giant Kepler HZ Candidates.

    Science.gov (United States)

    Hill, M.; Kane, S.; Kopparapu, R.; Seperuelo Duarte, E.; Gelino, D.; Whittenmyer, R.

    2017-12-01

    The NASA Kepler mission has discovered thousands of new planetary candidates, many of which have been confirmed through follow-up observations. A primary goal of the mission is to determine the occurrence rate of terrestrial-size planets within the Habitable Zone (HZ) of their host stars. A major product of the Habitable Zone Working Group (HZWG) is a list of HZ exoplanet candidates from the Kepler Data Release 24 Q1- Q17 data vetting process [1]. We used a variety of criteria regarding HZ boundaries and planetary sizes to produce complete lists of HZ candidates, including a catalog of 104 candidates within the optimistic HZ. We cross-matched our HZ candidates with the Data Release 25 stellar properties and confirmed planet properties to provide robust stellar parameters and candidate dispositions. We also performed dynamical analysis simulations for multi-planet systems that contain candidates with radii less than two Earth radii as a step toward validation of those systems. From this list we found 39 planet candidates greater than 3 earth radii residing in the Optimistic Habitable Zone of their host star. While giant planets are not favored in the search for eta Earth, they do indicate a potential for large, potentially rocky moons residing in the habitable zone. These giant planets can also provide a potential for a wider range of "habitable" incident flux due to additional energy sources from tidal energy, etc. Thus we analyzed each giant planet, estimating their mass and then calculating the estimated Radial Velocity Semi Amplitudes of each planet for use in follow up observations. We then calculated the planets Hill radius and determined the maximum angular separation of potential moons. This presentation will describe the highlights of the HZ catalog giant planets and the plans for further validation of HZ candidates and follow-up studies. Fig. 1 - Plots both the unconfirmed and confirmed Giant (>3⊕R) Kepler candidates expected Radial Velocity signatures

  8. The Left and Minority Representation: The Labour Party, Muslim Candidates, and Inclusion Tradeoffs.

    Science.gov (United States)

    Dancygier, Rafaela

    2013-10-01

    As ethnic diversity rises across Europe, the Left faces a trade-off between incorporating new minorities while retaining support from settled, working-class voters. Focusing on the Labour Party's selection of Muslims and employing a dataset containing over 42,000 local election candidates in England, this article argues that inclusion is less likely where core voters are most concerned about the representation of Muslims' material and religious interests: economically deprived areas with sizable Muslim populations. It shows that in these areas Muslim candidates underperform at the polls and Labour Parties are less likely to choose Muslim candidates here as a result. Selection thus varies based on the economic and cultural threats that Muslim representation poses to the Left's core constituency. These findings contribute to our understanding of the forces that shape ethnic minority political incorporation across contexts.

  9. Electoral Competition when Candidates are Better Informed than Voters

    DEFF Research Database (Denmark)

    Jensen, Thomas

    candidates are both completely office-motivated but differ in state-dependent quality. Voters have some information about the state but candidates are better informed. If voters' information is unknown to the candidates when they take positions and sufficiently accurate then candidates will, in refined...... equilibrium, reveal their information by converging to the most likely median. If voters' information is not sufficiently accurate then there is polarization and the candidates'information is not revealed to the voters. We also show that if voters'information is known to the candidates then they will never...

  10. Preliminary site description Forsmark area - version 1.2

    International Nuclear Information System (INIS)

    Skagius, Kristina

    2005-06-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) is undertaking site characterisation at two different locations, the Forsmark and Simpevarp areas, with the objective of siting a geological repository for spent nuclear fuel. An integrated component in the characterisation work is the development of a site descriptive model that constitutes a description of the site and its regional setting, covering the current state of the geosphere and the biosphere as well as those ongoing natural processes that affect their long-term evolution. The present report documents the site descriptive modelling activities (version 1.2) for the Forsmark area. The overall objectives of the version 1.2 site descriptive modelling are to produce and document an integrated description of the site and its regional environments based on the site-specific data available from the initial site investigations and to give recommendations on continued investigations. The modelling work is based on primary data, i.e. quality-assured, geoscientific and ecological field data available in the SKB databases SICADA and GIS, available July 31, 2004. The work has been conducted by a project group and associated discipline-specific working groups. The members of the project group represent the disciplines of geology, rock mechanics, thermal properties, hydrogeology, hydrogeochemistry, transport properties and surface ecosystems (including overburden, surface hydrogeochemistry and hydrology). In addition, some group members have specific qualifications of importance in this type of project e.g. expertise in RVS (Rock Visualisation System) modelling, GIS-modelling and in statistical data analysis. The overall strategy to achieve a site description is to develop discipline-specific models by interpretation and analyses of the primary data. The different discipline-specific models are then integrated into a site description. Methodologies for developing the discipline-specific models are documented in

  11. Preliminary site description Forsmark area - version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Skagius, Kristina (ed.)

    2005-06-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) is undertaking site characterisation at two different locations, the Forsmark and Simpevarp areas, with the objective of siting a geological repository for spent nuclear fuel. An integrated component in the characterisation work is the development of a site descriptive model that constitutes a description of the site and its regional setting, covering the current state of the geosphere and the biosphere as well as those ongoing natural processes that affect their long-term evolution. The present report documents the site descriptive modelling activities (version 1.2) for the Forsmark area. The overall objectives of the version 1.2 site descriptive modelling are to produce and document an integrated description of the site and its regional environments based on the site-specific data available from the initial site investigations and to give recommendations on continued investigations. The modelling work is based on primary data, i.e. quality-assured, geoscientific and ecological field data available in the SKB databases SICADA and GIS, available July 31, 2004. The work has been conducted by a project group and associated discipline-specific working groups. The members of the project group represent the disciplines of geology, rock mechanics, thermal properties, hydrogeology, hydrogeochemistry, transport properties and surface ecosystems (including overburden, surface hydrogeochemistry and hydrology). In addition, some group members have specific qualifications of importance in this type of project e.g. expertise in RVS (Rock Visualisation System) modelling, GIS-modelling and in statistical data analysis. The overall strategy to achieve a site description is to develop discipline-specific models by interpretation and analyses of the primary data. The different discipline-specific models are then integrated into a site description. Methodologies for developing the discipline-specific models are documented in

  12. [Nutritional deficiencies in candidates for bariatric surgery].

    Science.gov (United States)

    Ammor, Nadia; Berthoud, Laurie; Gerber, Aline; Giusti, Vittorio

    2009-03-25

    98% of patients who have undergone a gastric bypass for treating severe obesity develop multiple micronutrient deficits. However, prior to surgery, it isn't rare to find nutrient deficiencies. Indeed, the dietary intakes of surgery candidates are often unbalanced, lacking in variety especially in high vitamin and mineral nutrients. We present the preliminary results concerning the qualitative and quantitative analysis in a group of patients waiting for a gastric bypass. The recommended daily amounts in vitamin B9, vitamin D and iron are insufficient in the majority of the patients. The correction of nutritional intakes is advisable, even before the surgery, in order to reduce the risks of developing biological deficiencies.

  13. Blend Analysis of HATNet Transit Candidates

    Directory of Open Access Journals (Sweden)

    Bakos G.Á.

    2011-02-01

    Full Text Available Candidate transiting planet systems discovered by wide-field groundbased surveys must go through an intensive follow-up procedure to distinguish the true transiting planets from the much more common false positives. Especially pernicious are configurations of three or more stars which produce radial velocity and light curves that are similar to those of single stars transited by a planet. In this contribution we describe the methods used by the HATNet team to reject these blends, giving a few illustrative examples.

  14. Reducing stigma and discrimination: Candidate interventions

    Directory of Open Access Journals (Sweden)

    Kassam Aliya

    2008-04-01

    Full Text Available Abstract This paper proposes that stigma in relation to people with mental illness can be understood as a combination of problems of knowledge (ignorance, attitudes (prejudice and behaviour (discrimination. From a literature review, a series of candidate interventions are identified which may be effective in reducing stigmatisation and discrimination at the following levels: individuals with mental illness and their family members; the workplace; and local, national and international. The strongest evidence for effective interventions at present is for (i direct social contact with people with mental illness at the individual level, and (ii social marketing at the population level.

  15. Testing black hole candidates with electromagnetic radiation

    Science.gov (United States)

    Bambi, Cosimo

    2017-04-01

    Astrophysical black hole candidates are thought to be the Kerr black holes of general relativity, but there is not yet direct observational evidence that the spacetime geometry around these objects is described by the Kerr solution. The study of the properties of the electromagnetic radiation emitted by gas or stars orbiting these objects can potentially test the Kerr black hole hypothesis. This paper reviews the state of the art of this research field, describing the possible approaches to test the Kerr metric with current and future observational facilities and discussing current constraints.

  16. Processability analysis of candidate waste forms

    International Nuclear Information System (INIS)

    Gould, T.H. Jr.; Dunson, J.B. Jr.; Eisenberg, A.M.; Haight, H.G. Jr.; Mello, V.E.; Schuyler, R.L. III.

    1982-01-01

    A quantitative merit evaluation, or processability analysis, was performed to assess the relative difficulty of remote processing of Savannah River Plant high-level wastes for seven alternative waste form candidates. The reference borosilicate glass process was rated as the simplest, followed by FUETAP concrete, glass marbles in a lead matrix, high-silica glass, crystalline ceramics (SYNROC-D and tailored ceramics), and coated ceramic particles. Cost estimates for the borosilicate glass, high-silica glass, and ceramic waste form processing facilities are also reported

  17. Metaphors of Teacher Candidates' Regarding the Concept of "Non-Governmental Organizations" (NGOs)

    Science.gov (United States)

    Selanik-Ay, Tugba

    2016-01-01

    In this study, a learning area in social studies curriculum called "Groups, institutions and social organizations" was used. It can be seen that an important role for teachers in a social studies programme is to benefit from non-governmental organizations. The aim of this study is to investigate primary school teacher candidates' social…

  18. Mainstream Teacher Candidates' Perspectives on ESL Writing: The Effects of Writer Identity and Rater Background

    Science.gov (United States)

    Kang, Hyun-Sook; Veitch, Hillary

    2017-01-01

    This study explored the extent to which the ethnic identity of a writer and the background (gender and area of teaching) of a rater can influence mainstream teacher candidates' evaluation of English as a second language (ESL) writing, using a matched-guise method. A one-page essay was elicited from an ESL learner enrolled in an intensive English…

  19. SOME COORDINATES CONCERNING TAXATION IN THE EU CANDIDATE COUNTRIES

    Directory of Open Access Journals (Sweden)

    CARMEN COMANICIU

    2015-10-01

    Full Text Available For accession to European Union, tax area is of particular importance, because it recognizes the impact of taxation on economic growth and development, and indirect taxation significantly contributes to the formation of the EU budget resources. Without prejudice to the fiscal sovereignty of Member States, EU tax policy strategy aims establishing a framework that eliminate the tax obstacles that may affect cross-border economic activity, identify the actions on preventing and combating tax evasion, improve collaboration between tax administrations. Without claiming an exhaustive approach, through issues highlighted in this article, we will identify both the similarities and the particularities of taxation from Albania, Macedonia, Montenegro, Serbia and Turkey, and also manner in which taxation of the 5 EU candidate countries meets the requirements on the fiscal coordination and fiscal harmonization from EU tax policy perspective.

  20. Statistical Approaches to Candidate Biomarker Panel Selection.

    Science.gov (United States)

    Spratt, Heidi M; Ju, Hyunsu

    2016-01-01

    The statistical analysis of robust biomarker candidates is a complex process, and is involved in several key steps in the overall biomarker development pipeline (see Fig. 22.1, Chap. 19 ). Initially, data visualization (Sect. 22.1, below) is important to determine outliers and to get a feel for the nature of the data and whether there appear to be any differences among the groups being examined. From there, the data must be pre-processed (Sect. 22.2) so that outliers are handled, missing values are dealt with, and normality is assessed. Once the processed data has been cleaned and is ready for downstream analysis, hypothesis tests (Sect. 22.3) are performed, and proteins that are differentially expressed are identified. Since the number of differentially expressed proteins is usually larger than warrants further investigation (50+ proteins versus just a handful that will be considered for a biomarker panel), some sort of feature reduction (Sect. 22.4) should be performed to narrow the list of candidate biomarkers down to a more reasonable number. Once the list of proteins has been reduced to those that are likely most useful for downstream classification purposes, unsupervised or supervised learning is performed (Sects. 22.5 and 22.6, respectively).

  1. Nutritional Status of Bariatric Surgery Candidates

    Science.gov (United States)

    Al-Mutawa, Aliaa; Anderson, Alfred Kojo; Alsabah, Salman; Al-Mutawa, Mohammad

    2018-01-01

    Obesity is a global epidemic affecting populations globally. Bariatric surgery is an effective treatment for morbid obesity, and has increased dramatically. Bariatric surgery candidates frequently have pre-existing nutritional deficiencies that might exacerbate post-surgery. To provide better health care management pre- and post-bariatric surgery, it is imperative to establish the nutritional status of prospective patients before surgery. The aim of this study was to assess and provide baseline data on the nutritional status of bariatric candidates. A retrospective study was conducted on obese patients who underwent bariatric surgery from 2008 to 2015. The medical records of 1538 patients were reviewed for this study. Pre-operatively, the most commonly observed vitamin deficiencies were Vitamin D (76%) and Vitamin B12 (16%). Anemia and iron status parameters were low in a considerable number of patients before surgery, as follows: hemoglobin 20%, mean corpuscular volume (MCV) 48%, ferritin 28%, serum iron 51%, and transferrin saturation 60%. Albumin and transferrin were found to be low in 10% and 9% of the patients, respectively, prior to surgery. In addition to deficiencies, a great number of patients had hypervitaminosis pre-operatively. Excess levels of Vitamin B6 (24%) was the most remarkable. The findings in this study advocate a close monitoring and tailored supplementation pre- and post-bariatric surgery. PMID:29324643

  2. Nutritional Status of Bariatric Surgery Candidates.

    Science.gov (United States)

    Al-Mutawa, Aliaa; Anderson, Alfred Kojo; Alsabah, Salman; Al-Mutawa, Mohammad

    2018-01-11

    Obesity is a global epidemic affecting populations globally. Bariatric surgery is an effective treatment for morbid obesity, and has increased dramatically. Bariatric surgery candidates frequently have pre-existing nutritional deficiencies that might exacerbate post-surgery. To provide better health care management pre- and post-bariatric surgery, it is imperative to establish the nutritional status of prospective patients before surgery. The aim of this study was to assess and provide baseline data on the nutritional status of bariatric candidates. A retrospective study was conducted on obese patients who underwent bariatric surgery from 2008 to 2015. The medical records of 1538 patients were reviewed for this study. Pre-operatively, the most commonly observed vitamin deficiencies were Vitamin D (76%) and Vitamin B 12 (16%). Anemia and iron status parameters were low in a considerable number of patients before surgery, as follows: hemoglobin 20%, mean corpuscular volume (MCV) 48%, ferritin 28%, serum iron 51%, and transferrin saturation 60%. Albumin and transferrin were found to be low in 10% and 9% of the patients, respectively, prior to surgery. In addition to deficiencies, a great number of patients had hypervitaminosis pre-operatively. Excess levels of Vitamin B₆ (24%) was the most remarkable. The findings in this study advocate a close monitoring and tailored supplementation pre- and post-bariatric surgery.

  3. Nutritional Status of Bariatric Surgery Candidates

    Directory of Open Access Journals (Sweden)

    Aliaa Al-Mutawa

    2018-01-01

    Full Text Available Obesity is a global epidemic affecting populations globally. Bariatric surgery is an effective treatment for morbid obesity, and has increased dramatically. Bariatric surgery candidates frequently have pre-existing nutritional deficiencies that might exacerbate post-surgery. To provide better health care management pre- and post-bariatric surgery, it is imperative to establish the nutritional status of prospective patients before surgery. The aim of this study was to assess and provide baseline data on the nutritional status of bariatric candidates. A retrospective study was conducted on obese patients who underwent bariatric surgery from 2008 to 2015. The medical records of 1538 patients were reviewed for this study. Pre-operatively, the most commonly observed vitamin deficiencies were Vitamin D (76% and Vitamin B12 (16%. Anemia and iron status parameters were low in a considerable number of patients before surgery, as follows: hemoglobin 20%, mean corpuscular volume (MCV 48%, ferritin 28%, serum iron 51%, and transferrin saturation 60%. Albumin and transferrin were found to be low in 10% and 9% of the patients, respectively, prior to surgery. In addition to deficiencies, a great number of patients had hypervitaminosis pre-operatively. Excess levels of Vitamin B6 (24% was the most remarkable. The findings in this study advocate a close monitoring and tailored supplementation pre- and post-bariatric surgery.

  4. Serological profile of candidates for corneal donation

    Directory of Open Access Journals (Sweden)

    Adroaldo Lunardelli

    2014-10-01

    Full Text Available Objetive: The purpose of this study is to map the serological profile of candidates to corneal donation at Irmandade Santa Casa de Misericórdia de Porto Alegre, identifying the percentage of disposal by serology and the marker involved. Methods: There have been analised – retrospectively – the results of serology of all corneal donors, made between the period of 1st january 2006 and 31st december 2012. Data analised were related to age, gender and the results of serology pertinent to viral markers (HBsAg, anti-HBc, anti-HCV and anti-HIV, these, determined by immunosorbent tests (ELISA. Results: In the period of the study, there were 2476 corneal donors at the institution, with a major incidence on the male gender, on an average of 58.7 years old. 23% of retention because of serological unfitness was also identified, that is, 570 samples were non-negative to any of the used tests. The marker anti- HBc was the most prevalent on the studied population, followed by the Hepatitis C virus (HCV and by the Human Immunodeficiency Virus (HIV. Conclusion: From the data found through this study, it is essential to have the participation of an efficient service on the serological evaluation of the candidates to corneal donation, once the security of the receptor must be taken into consideration in a population of donors with 23% of unfitness prevalence, in which the most prevalent marker is the one of Hepatits B.

  5. Confirmation of Kepler Planet Candidates around Giants

    Science.gov (United States)

    Sato, Bun-ei

    2014-01-01

    Detecting planetary transits is extremely valuable not only because it makes an independent confirmation of a planet from Doppler method but also because the photometric transits yield unambiguous information on planet masses and radii, and thus mean density and interior structure, and obliquity of planetary orbits. Planets around giants and subgiants have been intensively surveyed over the decade by precise radial velocity (RV) measurements, mainly from the viewpoint of planet searches around intermediate-mass (1.5-5M⊙) stars. The planets show remarkable properties in their masses and orbital parameters. Unfortunately, however, it is quite difficult to detect transiting ones around such evolved stars because of the large sizes of the host stars. Therefore, our understanding of properties of planets around intermediate-mass stars are still far behind from those around solar-like stars. In S13B, we made the first RV follow-up observations with HDS for the transiting planet candidates around giants found by Kepler space telescope, and identified promising candidates of true transiting planets. Here we propose to take additional RV data for them with HDS in order to make sure that the RV periodicity is the same as the transit one.

  6. Vaccine candidates for leishmaniasis: a review.

    Science.gov (United States)

    Nagill, Rajeev; Kaur, Sukhbir

    2011-10-01

    Leishmaniasis is a diverse group of clinical syndromes caused by protozoan parasites of the genus Leishmania. The clinical manifestation of the disease varies from self-limiting cutaneous lesions to progressive visceral disease. It is estimated that 350 million people are at risk in 88 countries, with a global incidence of 1-1.5 million cases of cutaneous and 500,000 cases of visceral leishmaniasis. The key control measures mainly rely on early case detection and chemotherapy which has been hampered by the toxicity of drugs, side-effects and by the emergence of drug resistance in parasites. Control of reservoir host and vector is difficult due to operational difficulties and frequent relapses in the host. Therefore, the development of effective and affordable vaccine against leishmaniasis is highly desirable. Although considerable progress has been made over the last decade in understanding immune mechanisms underlying potential candidate antigens, including killed, live attenuated parasites, crude parasites, pure or recombinant Leishmania proteins or DNA encoding leishmanial proteins, as well as immunomodulators from sand fly saliva, very few candidate vaccines have progressed beyond the experimental stage. As such there is no vaccine against any form of human leishmaniasis. In recent years, however, much interest has been stimulated towards vaccination against leishmaniasis focused mainly on cutaneous leishmaniasis with fewer attempts against visceral leishmaniasis. Copyright © 2011 Elsevier B.V. All rights reserved.

  7. Nonclinical Development of BCG Replacement Vaccine Candidates

    Directory of Open Access Journals (Sweden)

    Bernd Eisele

    2013-04-01

    Full Text Available The failure of current Mycobacterium bovis bacille Calmette–Guérin (BCG vaccines, given to neonates to protect against adult tuberculosis and the risk of using these live vaccines in HIV-infected infants, has emphasized the need for generating new, more efficacious and safer replacement vaccines. With the availability of genetic techniques for constructing recombinant BCG (rBCG strains containing well-defined gene deletions or insertions, new vaccine candidates are under evaluation at both the preclinical and clinical stages of development. Since most BCG vaccines in use today were evaluated in clinical trials decades ago and are produced by outdated processes, the development of new BCG vaccines offers a number of advantages that include a modern well-defined manufacturing process along with state-of-the-art evaluation of safety and efficacy in target populations. We provide a description of the preclinical development of two novel rBCGs, VPM1002 that was constructed by adding a modified hly gene coding for the protein listeriolysin O (LLO from Listeria monocytogenes and AERAS-422, which carries a modified pfoA gene coding for the protein perfringolysin O (PFO from Clostridium perfringens, and three genes from Mycobacterium tuberculosis. Novel approaches like these should be helpful in generating stable and effective rBCG vaccine candidates that can be better characterized than traditional BCG vaccines.

  8. Advanced Vaccine Candidates for Lassa Fever

    Directory of Open Access Journals (Sweden)

    Igor S. Lukashevich

    2012-10-01

    Full Text Available Lassa virus (LASV is the most prominent human pathogen of the Arenaviridae. The virus is transmitted to humans by a rodent reservoir, Mastomys natalensis, and is capable of causing lethal Lassa Fever (LF. LASV has the highest human impact of any of the viral hemorrhagic fevers (with the exception of Dengue Fever with an estimated several hundred thousand infections annually, resulting in thousands of deaths in Western Africa. The sizeable disease burden, numerous imported cases of LF in non-endemic countries, and the possibility that LASV can be used as an agent of biological warfare make a strong case for vaccine development. Presently there is no licensed vaccine against LF or approved treatment. Recently, several promising vaccine candidates have been developed which can potentially target different groups at risk. The purpose of this manuscript is to review the LASV pathogenesis and immune mechanisms involved in protection. The current status of pre-clinical development of the advanced vaccine candidates that have been tested in non-human primates will be discussed. Major scientific, manufacturing, and regulatory challenges will also be considered.

  9. Elemental abundances of solar sibling candidates

    Energy Technology Data Exchange (ETDEWEB)

    Ramírez, I.; Lambert, D. L.; Endl, M.; Cochran, W. D.; MacQueen, P. J. [McDonald Observatory and Department of Astronomy, University of Texas at Austin, 2515 Speedway, Stop C1400, Austin, Texas 78712-1205 (United States); Bajkova, A. T.; Bobylev, V. V. [Central (Pulkovo) Astronomical Observatory of RAS, 65/1, Pulkovskoye Chaussee, St. Petersburg 196140 (Russian Federation); Roederer, I. U. [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109 (United States); Wittenmyer, R. A. [School of Physics, UNSW Australia, Sydney 2052 (Australia)

    2014-06-01

    Dynamical information along with survey data on metallicity and in some cases age have been used recently by some authors to search for candidates of stars that were born in the cluster where the Sun formed. We have acquired high-resolution, high signal-to-noise ratio spectra for 30 of these objects to determine, using detailed elemental abundance analysis, if they could be true solar siblings. Only two of the candidates are found to have solar chemical composition. Updated modeling of the stars' past orbits in a realistic Galactic potential reveals that one of them, HD 162826, satisfies both chemical and dynamical conditions for being a sibling of the Sun. Measurements of rare-element abundances for this star further confirm its solar composition, with the only possible exception of Sm. Analysis of long-term high-precision radial velocity data rules out the presence of hot Jupiters and confirms that this star is not in a binary system. We find that chemical tagging does not necessarily benefit from studying as many elements as possible but instead from identifying and carefully measuring the abundances of those elements that show large star-to-star scatter at a given metallicity. Future searches employing data products from ongoing massive astrometric and spectroscopic surveys can be optimized by acknowledging this fact.

  10. Mirror Images: Teacher Candidates' Perceptions of Disposition Development

    Science.gov (United States)

    Bercaw, Lynne A.; Summers, Deborah G.; Colby, Susan A.; Payne, Maggie

    2012-01-01

    The complexity of disposition development for teacher candidates continues to be discussed and debated in teacher education. This study compares two programs and the different ways each approaches the disposition development of their respective candidates. More than 200 candidates from two institutions were surveyed on how and where they perceived…

  11. 29 CFR 452.62 - Disqualification of candidates; procedural reasons.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Disqualification of candidates; procedural reasons. 452.62 Section 452.62 Labor Regulations Relating to Labor OFFICE OF LABOR-MANAGEMENT STANDARDS, DEPARTMENT OF... candidates; procedural reasons. A candidate who is otherwise eligible for office may not be disqualified...

  12. Opinions of the Geography Teacher Candidates toward Mind Maps

    Science.gov (United States)

    Seyihoglu, Aysegul

    2013-01-01

    The purpose of this study is to reveal the opinions of the teacher candidates about mind mapping technique used in Geography education of undergraduate program. In this study, the qualitative research techniques were used. The study group consists of 55 teacher candidates. The teacher candidates have been asked for their opinions about the process…

  13. Cognitive Styles in Admission Procedures for Assessing Candidates of Architecture

    Science.gov (United States)

    Casakin, Hernan; Gigi, Ariela

    2016-01-01

    Cognitive style has a strong predictive power in academic and professional success. This study investigated the cognitive profile of candidates studying architecture. Specifically, it explored the relation between visual and verbal cognitive styles, and the performance of candidates in admission procedures. The cognitive styles of candidates who…

  14. Political Candidate Campaign Advertising: A Selected Review of the Literature.

    Science.gov (United States)

    Hellweg, Susan A.

    This paper provides a selected review of political candidate campaign advertising studies from the political science, mass communication, advertising, and political communication literature. The paper examines the literature in terms of research pertaining to (1) candidate advertising content (commercials for male versus female candidates and for…

  15. A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137

    Science.gov (United States)

    Devanna, Paolo; Vernes, Sonja C.

    2014-02-01

    Retinoic acid-related orphan receptor alpha gene (RORa) and the microRNA MIR137 have both recently been identified as novel candidate genes for neuropsychiatric disorders. RORa encodes a ligand-dependent orphan nuclear receptor that acts as a transcriptional regulator and miR-137 is a brain enriched small non-coding RNA that interacts with gene transcripts to control protein levels. Given the mounting evidence for RORa in autism spectrum disorders (ASD) and MIR137 in schizophrenia and ASD, we investigated if there was a functional biological relationship between these two genes. Herein, we demonstrate that miR-137 targets the 3'UTR of RORa in a site specific manner. We also provide further support for MIR137 as an autism candidate by showing that a large number of previously implicated autism genes are also putatively targeted by miR-137. This work supports the role of MIR137 as an ASD candidate and demonstrates a direct biological link between these previously unrelated autism candidate genes.

  16. What Do Teacher Candidates Think about the Teaching Education? The Example of Social Studies Teacher Candidates

    Science.gov (United States)

    Tonga, Deniz

    2016-01-01

    In this research, it is aimed to reveal the opinions and observations of social studies teacher candidate about the courses they have taken during their 4-year university education. The focus group interview was used as the data collecting tool, and the content analyses were performed on the data obtained. The criterion sampling approach was used…

  17. Deep repository for spent nuclear fuel. Facility description - Layout E. Spiral ramp with one operational area

    Energy Technology Data Exchange (ETDEWEB)

    Pettersson, Stig [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Forsgren, Ebbe [SwedPower AB, Stockholm (Sweden); Lange, Fritz [Lange Art AB, Stockholm (Sweden)

    2002-04-01

    below ground. The proposal is based on a hypothetical inland location with a rail link. The report describes a layout with a spiral ramp as access to the deposition area and with a single operational area above ground. The ramp will be used as a transport route for heavy and bulky transports. A shaft, that connects the operational area with the central area of the deposition area, is used for utility systems and for staff transports between the surface and the deposition area. It has been assumed that the deposition areas and the central area are on the same level. The appendix, describing a two level alternative, shows how the underground area could be arranged if the deposition area for regular operation were to be divided into two levels. The facility description concentrates on the situation during regular operation. It also describes the gradual expansion programme, including land requirements and connections to existing infrastructure. The report concludes with some perspective sketches, which give a vision of how the repository might look when ready for operation. This facility description is a translation of the Swedish SKB report R-02-18. It is important to note that the report gives an example of one possible design for the deep repository. Many issues concerning system design, functional solutions, layout and design ought to be investigated further before deciding on the final design.

  18. Deep repository for spent nuclear fuel. Facility description - Layout E. Spiral ramp with one operational area

    International Nuclear Information System (INIS)

    Pettersson, Stig; Forsgren, Ebbe; Lange, Fritz

    2002-04-01

    ground. The proposal is based on a hypothetical inland location with a rail link. The report describes a layout with a spiral ramp as access to the deposition area and with a single operational area above ground. The ramp will be used as a transport route for heavy and bulky transports. A shaft, that connects the operational area with the central area of the deposition area, is used for utility systems and for staff transports between the surface and the deposition area. It has been assumed that the deposition areas and the central area are on the same level. The appendix, describing a two level alternative, shows how the underground area could be arranged if the deposition area for regular operation were to be divided into two levels. The facility description concentrates on the situation during regular operation. It also describes the gradual expansion programme, including land requirements and connections to existing infrastructure. The report concludes with some perspective sketches, which give a vision of how the repository might look when ready for operation. This facility description is a translation of the Swedish SKB report R-02-18. It is important to note that the report gives an example of one possible design for the deep repository. Many issues concerning system design, functional solutions, layout and design ought to be investigated further before deciding on the final design

  19. Chronic hyperplastic candidosis/candidiasis (candidal leukoplakia).

    Science.gov (United States)

    Sitheeque, M A M; Samaranayake, L P

    2003-01-01

    Chronic hyperplastic candidosis/candidiasis (CHC; syn. candidal leukoplakia) is a variant of oral candidosis that typically presents as a white patch on the commissures of the oral mucosa. The major etiologic agent of the disease is the oral fungal pathogen Candida predominantly belonging to Candida albicans, although other systemic co-factors, such as vitamin deficiency and generalized immune suppression, may play a contributory role. Clinically, the lesions are symptomless and regress after appropriate antifungal therapy and correction of underlying nutritional or other deficiencies. If the lesions are untreated, a minor proportion may demonstrate dysplasia and develop into carcinomas. This review outlines the demographic features, etiopathogenesis, immunological features, histopathology, and the role of Candida in the disease process. In the final part of the review, newer molecular biological aspects of the disease are considered together with the management protocols that are currently available, and directions for future research.

  20. ELECTIONS PENSION FUND 3rd candidate

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : Hauviller First Name : Claude Dear colleague of CERN and ESO, For the first time, I am standing and requesting your support to become a member of the Governing Board of our Pension Fund. CERN staff member since 1974, I have already carried elective mandates: I have been Delegate to the Staff Council and Member of the Senior Staff Consultative Committee (the Nine). For the majority of us, our Pension Fund is our only social provident scheme and source of retirement income; I believe I can usefully contribute to its successful management and help ensure its balance. Our Fund reaches its majority: soon, there will be more beneficiaries tha...

  1. ELECTIONS PENSION FUND CANDIDATE NR 3

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : HAUVILLER First Name : Claude Dear colleague of CERN and ESO, For the first time, I am standing and requesting your support to become a member of the Governing Board of our Pension Fund. CERN staff member since 1974, I have already carried elective mandates: I have been Delegate to the Staff Council and Member of the Senior Staff Consultative Committee (the Nine). For the majority of us, our Pension Fund is our only social provident scheme and source of retirement income; I believe I can usefully contribute to its successful management and help ensure its balance. Our Fund reaches its majority: soon, there will be more beneficiaries tha...

  2. Alcoholism and Alternative Splicing of Candidate Genes

    Directory of Open Access Journals (Sweden)

    Toshikazu Sasabe

    2010-03-01

    Full Text Available Gene expression studies have shown that expression patterns of several genes have changed during the development of alcoholism. Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss some of the evidence suggesting that alternative splicing of candidate genes such as DRD2 (encoding dopamine D2 receptor may form the basis of the mechanisms underlying the pathophysiology of alcoholism. These reports suggest that aberrant expression of splice variants affects alcohol sensitivities, and alcohol consumption also regulates alternative splicing. Thus, investigations of alternative splicing are essential for understanding the molecular events underlying the development of alcoholism.

  3. ELECTIONS PENSION FUND CANDIDATE NR 4

    CERN Document Server

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : MYERS First Name : Stephen I have been at CERN since 1972, and was elected member of the Governing Board for the first time in 1998. The Governing Board then nominated me to the Investments Committee where I have been a member since the beginning of 1999. Since then I have actively participated in redefining and transforming the investment portfolio in order to improve the overall return and where possible reduce the risk. The portfolio has recently been greatly improved and now allows much simpler more transparent monitoring of our investment. I have also actively participated and hopefully made useful contributions in discussions conc...

  4. ELECTIONS PENSION FUND 4th candidate

    CERN Document Server

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : MYERS First Name : Stephen I have been at CERN since 1972, and was elected member of the Governing Board for the first time in 1998. The Governing Board then nominated me to the Investments Committee where I have been a member since the beginning of 1999. Since then I have actively participated in redefining and transforming the investment portfolio in order to improve the overall return and where possible reduce the risk. The portfolio has recently been greatly improved and now allows much simpler more transparent monitoring of our investment. I have also actively participated and hopefully made useful contributions in discussions conc...

  5. Nutritional deficiencies in bariatric surgery candidates.

    Science.gov (United States)

    Schweiger, Chaya; Weiss, Ram; Berry, Elliot; Keidar, Andrei

    2010-02-01

    To assess the prevalence of nutritional deficiencies amongst people who suffer from morbid obesity and are candidates for bariatric surgery and to evaluate the relations between pre-operative nutritional deficiencies and demographic data and co-morbidities. Preoperative blood tests of 114 patients (83 women and 31 men) were collected. The blood tests included plasma chemistry (including albumin, total protein, iron, ferritin, vitamin B12, folic acid, parathyroid hormone (PTH), calcium, and phosphorous) and a blood count (for hemoglobin and mean corpuscular volume (MCV)). Demographic and socio-economic details were collected from all patients. Mean age, weight, and BMI of the patients were 38 years (15-77), 122.9 kg (87-250), and 44.3 kg/m(2) (35.3-74.9), respectively. The prevalence of pre-operative nutritional deficiencies were: 35% for iron, 24% for folic acid, 24% for ferritin, 3.6% for vitamin B12, 2% for phosphorous, and 0.9% for calcium, Hb and MCV level was low in 19%. High levels of PTH were found among 39% of the patients. No hypoalbuminemia was encountered. Low iron was more common in females relative to men (40.8 vs.14.3%, p = 0.04) as well as ferritin levels (31.8 vs. 0%, p = 0.001). Men showed a greater prevalence of anemia (35.5% and 12% respectively, p = 0.01) relative to women. Patients with BMI > 50 kg/m(2) were at greater risk for low folic acid (OR = 14.57, 95% CI:1.4-151.34). Patients with high income were less likely to have iron deficiency (OR = 0.19, 95% CI:0.038-0.971). A high prevalence of nutritional deficiencies was found amongst bariatric surgery candidates suffering from morbid obesity.

  6. Ecosystem site description - an approach to quantify transport and accumulation of matter in a drainage area

    International Nuclear Information System (INIS)

    Soderback, B.; Kautsky, U.; Lindborg, T.

    2004-01-01

    The Swedish Nuclear Fuel and Waste Management Co. (SKB) presently perform site investigations at two sites in Sweden for a future repository of spent nuclear fuel. The safety assessment of a potential repository will, among other methods, use an approach where transport and accumulation of radionuclides is modelled by quantifying the pathways of carbon/nitrogen/phosphorous in the ecosystem. Since water is the most important medium for transportation of matter, the obvious delimitation of an area for quantification of matter transport is the drainage area. This study describes how site-specific data on surface water chemistry and hydrology, measured at several points along the flow paths of a drainage area, can be used to describe and quantify the flow of matter in terms of transport or accumulation. The approach was applied to the drainage area of Lake Eckarfjaerden, investigated as part of the site investigation programme at Forsmark in central Sweden. By using data from inlet and outlet of the lake, together with data from the lake itself, we quantified the flow of matter in the drainage area, and also developed mass-balance budgets for important elements. The results were used to validate process oriented terrestrial and aquatic ecosystem models, developed for the same drainage area in parallel to the present study. In conclusion, applying this approach will contribute substantially to our understanding of the processes controlling transport and accumulation of matter in a drainage area, and thereby reduce the uncertainties in estimating radionuclide flow and consequences to humans and the environment. (author)

  7. Identification of single nucleotide polymorphisms (SNPs) at candidate genes involved in abiotic stress in two Prosopis species of hybrids

    OpenAIRE

    Maria F. Pomponio; Susana Marcucci Poltri; Diego Lopez Lauenstein; Susana Torales

    2014-01-01

    Aim of the study: Identify and compare SNPs on candidate genes related to abiotic stress in Prosopis chilensis, Prosopis flexuosa and interspecific hybridsArea of the study: Chaco árido, Argentina. Material and Methods: Fragments from 6 candidate genes were sequenced in 60 genotypes. DNA polymorphisms were analyzed.Main Results: The analysis revealed that the hybrids had the highest rate of polymorphism, followed by P. flexuosa and P. chilensis, the values found are comparable to other forest...

  8. Candidate Quality Measures for Hand Surgery.

    Science.gov (United States)

    2017-11-01

    Quality measures are tools used by physicians, health care systems, and payers to evaluate performance, monitor the outcomes of interventions, and inform quality improvement efforts. A paucity of quality measures exist that address hand surgery care. We completed a RAND/UCLA (University of California Los Angeles) Delphi Appropriateness process with the goal of developing and evaluating candidate hand surgery quality measures to be used for national quality measure development efforts. A consortium of 9 academic upper limb surgeons completed a RAND/UCLA Delphi Appropriateness process to evaluate the importance, scientific acceptability, usability, and feasibility of 44 candidate quality measures. These addressed hand problems the panelists felt were most appropriate for quality measure development. Panelists rated the measures on an ordinal scale between 1 (definitely not valid) and 9 (definitely valid) in 2 rounds (preliminary round and final round) with an intervening face-to-face discussion. Ratings from 1 to 3 were considered not valid, 4 to 6 as equivocal or uncertain, and 7 to 9 as valid. If no more than 2 of the 9 ratings were outside the 3-point range that included the median (1-3, 4-6, or 7-9), the panelists were considered to be in agreement. If 3 or more of the panelists' ratings of a measure were within the 1 to 3 range and 3 or more ratings were in the 7 to 9 range, the panelists were considered to be in disagreement. There was agreement on 43% (19) of the measures as important, 27% (12) as scientifically sound, 48% (21) as usable, and 59% (26) as feasible to complete. Ten measures met all 4 of these criteria and were, therefore, considered valid measurements of quality. Quality measures that were developed address outcomes (patient-reported outcomes for assessment and improvement of function) and processes of care (utilization rates of imaging, antibiotics, occupational therapy, ultrasound, and operative treatment). The consortium developed 10

  9. Virus-like particles as nanovaccine candidates

    Science.gov (United States)

    Guillen, G.; Aguilar, J. C.; Dueñas, S.; Hermida, L.; Iglesias, E.; Penton, E.; Lobaina, Y.; Lopez, M.; Mussachio, A.; Falcon, V.; Alvarez, L.; Martinez, G.; Gil, L.; Valdes, I.; Izquierdo, A.; Lazo, L.; Marcos, E.; Guzman, G.; Muzio, V.; Herrera, L.

    2013-03-01

    The existing vaccines are mainly limited to the microorganisms we are able to culture and produce and/or to those whose killing is mediated by humoral response (antibody mediated). It has been more difficult to develop vaccines capable of inducing a functional cellular response needed to prevent or cure chronic diseases. New strategies should be taken into account in the improvement of cell-based immune responses in order to prevent and control the infections and eventually clear the virus. Preclinical and clinical results with vaccine candidates developed as a vaccine platform based on virus-like particles (VLPs) evidenced their ability to stimulate mucosal as well as systemic immunity. Particles based on envelope, membrane or nucleocapsid microbial proteins induce a strong immune response after nasal or parenteral administration in mice, non-human primates and humans. In addition, the immune response obtained was modulated in a Th1 sense. The VLPs were also able to immunoenhance the humoral and cellular immune responses against several viral pathogens. Studies in animals and humans with nasal and systemic formulations evidenced that it is possible to induce functional immune response against HBV, HCV, HIV and dengue virus. Invited talk at the 6th International Workshop on Advanced Materials Science and Nanotechnology, 30 October - 2 November 2012, Ha Long, Vietnam.

  10. ELECTIONS PENSION FUND CANDIDATE NO 2

    CERN Multimedia

    2000-01-01

    This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund.   Candidate: Name: RANJARDFirst Name: Florence Having been a member of the Governing Board of the Pension Fund since 1983 as Guy Maurin’s alternate, I am standing for a further 3-year term of office. Over the past few years work has concentrated essentially on following items: Monitoring of the work of the fund managers and their performances. The three-yearly study of the Fund’s actuarial situation. The pension guarantees ­ second phase. The Fund is approaching its maturity: the level of benefits exceeds contributions. In this context it has to strike a suitable balance between management of the risk from a dynamic investment policy, while a prudent policy avoiding any significant loss of its capital. These will be my concerns within the Governing Board of the Pension Fund if you...

  11. ELECTIONS PENSION FUND CANDIDATE NO 1

    CERN Multimedia

    2000-01-01

    This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name: MAURINFirst Name:Guy I have been a member of the personnel since 1967 and as early as 1972 I was involved, in my capacity as President of the Staff Association, in the improvement of the Pension Fund benefits. As for most of us the Pension Fund is the only social provident scheme to which we belong, it is important to ensure that it is well managed and in balance. As a member of the Governing Board since 1974 and Vice-Chairman of this Board since 1977, I have continued to pursue these objectives.One of the main responsibilities of the Governing Board is our asset investment policy. The Investment Committee, of which I am Chairman, must have an overall view of the management of our 4 billion Swiss francs and seek the best yield with minimum risk. The investment structure must continuously be adapted...

  12. Cochlear implant candidates with psychogenic hearing loss.

    Science.gov (United States)

    Kompis, Martin; Senn, Pascal; Mantokoudis, Georgios; Caversaccio, Marco

    2015-04-01

    Specific requests for cochlear implantations by persons with psychogenic hearing loss are a relatively new phenomenon. A number of features seems to be over-represented in this group of patients. The existence of these requests stresses the importance of auditory brainstem response (ABR) measurements before cochlear implantation. To describe the phenomenon of patients with psychogenic hearing losses specifically requesting cochlear implantation, and to gain first insights into the characteristics of this group. Analysis of all cases seen between 2004 and 2013 at the University Hospital of Bern, Switzerland. Four cochlear implant candidates with psychogenic hearing loss were identified. All were female, aged 23-51 years. Hearing thresholds ranged from 86 dB to 112 dB HL (pure-tone average 500-4000 Hz). ABRs and otoacoustic emissions (OAEs) showed bilaterally normal hearing in two subjects, and hearing thresholds between 30 and 50 dB in the other two subjects. Three subjects suffered from depression and one from a pathologic fear of cancer. Three had a history of five or more previous surgeries. Three were smokers and three reported other close family members with hearing losses. All four were hearing aid users at the time of presentation.

  13. AF-2364 is a prospective spermicide candidate.

    Science.gov (United States)

    Wang, Hui; Chen, Xiang-Xiang; Wang, Li-Rong; Mao, Yun-Dong; Zhou, Zuo-Min; Sha, Jia-Hao

    2010-05-01

    AbstractInhibition of sperm motility has recently become a promising target for male contraceptive development. AF-2364, an analogue of Lonidamine (LND), had a contraceptive effect when orally administered to adult Sprague-Dawley rats. LND can also target mitochondria to inhibit oxygen consumption and block energy metabolism in tumour cells. However, there are no reports of the effects of AF-2364 on human sperm function. Herein we describe the action of AF-2364 on human sperm in vitro, as well as the mechanisms involved. AF-2364 specifically blocked human sperm motility in vitro. Further experiments revealed that AF-2364 can target sperm mitochondrial permeability transition (MPT) pores to induce the loss of sperm mitochondrial membrane potential (DeltaPsim) and decrease ATP generation; however, no significant changes in the cytoskeletal network or the human sperm proteome were detected after exposure to AF-2364. Incubation of AF-2364 with other human or mouse cell lines indicated that the spermicidal effect at the lower concentration was specific. In summary, the spermicidal effect of AF-2364 involves direct action on sperm MPT pores, and this compound should be further investigated as a new spermicide candidate.

  14. ELECTIONS PENSION FUND CANDIDATE NR 2

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : FRANDSEN First Name : Poul Kjaer  I have been member of the staff since 1974, and member of staff council for more than 12 years, and my main motivation has been to work for improving the social conditions of the CERN staff. A very important pillar of this is a sound and healthy pension fund. A capitalised scheme has been and still is the best choice for assuring the benefits for the CERN staff, present and future, this social system being part of the whole necessary to attract the best staff to the future High Energy Physics in Europe. However, even the hypothetic close down of the Organisation should allow the benefits to exi...

  15. ELECTIONS PENSION FUND 2nd candidate

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : FRANDSEN First Name : Poul Kjaer  I have been member of the staff since 1974, and member of staff council for more than 12 years, and my main motivation has been to work for improving the social conditions of the CERN staff. A very important pillar of this is a sound and healthy pension fund. A capitalised scheme has been and still is the best choice for assuring the benefits for the CERN staff, present and future, this social system being part of the whole necessary to attract the best staff to the future High Energy Physics in Europe. However, even the hypothetic close down of the Organisation should allow the benefits to exi...

  16. Virus-like particles as nanovaccine candidates

    International Nuclear Information System (INIS)

    Guillen, G; Aguilar, J C; Dueñas, S; Hermida, L; Iglesias, E; Penton, E; Lobaina, Y; Lopez, M; Mussachio, A; Falcon, V; Alvarez, L; Martinez, G; Gil, L; Valdes, I; Izquierdo, A; Lazo, L; Marcos, E; Guzman, G; Muzio, V; Herrera, L

    2013-01-01

    The existing vaccines are mainly limited to the microorganisms we are able to culture and produce and/or to those whose killing is mediated by humoral response (antibody mediated). It has been more difficult to develop vaccines capable of inducing a functional cellular response needed to prevent or cure chronic diseases. New strategies should be taken into account in the improvement of cell-based immune responses in order to prevent and control the infections and eventually clear the virus. Preclinical and clinical results with vaccine candidates developed as a vaccine platform based on virus-like particles (VLPs) evidenced their ability to stimulate mucosal as well as systemic immunity. Particles based on envelope, membrane or nucleocapsid microbial proteins induce a strong immune response after nasal or parenteral administration in mice, non-human primates and humans. In addition, the immune response obtained was modulated in a Th1 sense. The VLPs were also able to immunoenhance the humoral and cellular immune responses against several viral pathogens. Studies in animals and humans with nasal and systemic formulations evidenced that it is possible to induce functional immune response against HBV, HCV, HIV and dengue virus. (paper)

  17. ELECTIONS PENSION FUND CANDIDATE NR 5

    CERN Document Server

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate :  Name : Sonnemann  First Name : Florian Since my arrival at CERN in 1997 I have worked in the accelerator and administrative sectors. I have recently been elected as member of the Staff Council and of the Executive Committee of the Staff Association in which I am actively following matters concerning the Pension Fund. My candidature for the Governing Board of the CERN Pension Fund is mainly motivated to add my part in ensuring a solid financial situation of the Pension Fund. The Pension Fund is our only social security system. I wish to play a role in ensuring that the pensions will remain a secure revenue for all staff membe...

  18. ELECTIONS PENSION FUND 5th candidate

    CERN Document Server

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate :  Name : Sonnemann  First Name : Florian Since my arrival at CERN in 1997 I have worked in the accelerator and administrative sectors. I have recently been elected as member of the Staff Council and of the Executive Committee of the Staff Association in which I am actively following matters concerning the Pension Fund. My candidature for the Governing Board of the CERN Pension Fund is mainly motivated to add my part in ensuring a solid financial situation of the Pension Fund. The Pension Fund is our only social security system. I wish to play a role in ensuring that the pensions will remain a secure revenue for all staff membe...

  19. The FK Comae candidate UX Librae

    Science.gov (United States)

    Bopp, B. W.; Goodrich, B. D.; Africano, J. L.; Noah, P. V.; Meredith, R. J.; Palmer, L. H.; Quigley, R. J.

    1984-01-01

    New optical spectroscopic and photometric data are presented for the active chromosphere FK Com candidate UZ Lib. The star is shown to have an extremely large photometric amplitude in V of 0.35 mag, and its rotation period is established as 4.75 + or - 0.01 days. The optical spectrum is that of an early K giant, broadened by a rotation velocity of approximately 65 km/s. H-alpha is visible as a very broad emission feature, with a profile resembling that seen in FK Com. The emission intensity and profile are variable over the rotation period, with the strongest emission present at photometric minimum, in accord with dark starspot models. The photospheric absorption line profiles show variable asymmetries and distortions which are interpreted as due to the effects of the dark starspot rotating across the line of sight. New radial velocity measures are combined with published data to demonstrate the UZ Lib is a member of a binary system in synchronous rotation with a secondary of mass approximately 0.5 solar masses. This information is considered in light of the conflicting models for the origin of the optical and spectral variability of the FK Com stars, as well as their uncertain evolutionary status.

  20. A systematic review of public health-aligned recommendations for preparing physical education teacher candidates.

    Science.gov (United States)

    Webster, Collin A; Webster, Liana; Russ, Laura; Molina, Sergio; Lee, Heesu; Cribbs, Jason

    2015-03-01

    Since Sallis and McKenzie's seminal article in 1991 outlining physical education's role in public health, increased attention has been given to promoting youth physical activity in schools. The present study systematically reviewed the literature from 1991 to 2013 to identify recommendations for the preparation of physical education teacher candidates (PETCs) from a public health perspective. Eight online databases (e.g., Educational Resources Information Center, Google Scholar) served as data sources for the study. Multiple combinations of key terms (e.g., physical education teacher education [PETE], public health, health-oriented) were used to identify relevant literature meeting search criteria. A content analysis was used to identify 47 distinct recommendations from 25 included articles and to synthesize these recommendations into major areas of focus. Three major areas of focus were identified: (a) candidate profile (e.g., PETCs should be physically active and fit role models), (b) candidate knowledge (e.g., PETCs should know about behavior change theories), and (c) candidate skills (e.g., PETCs should be able to advocate for school-based physical activity). This review can serve as a blueprint for PETE programs seeking to align professional preparation with public health goals.

  1. A Research on the Comparison of the MultipleIntelligince Types of the Candidates Who Succeeded and Failedinthe Entrance Exams of Physical Educationand Sports School

    Directory of Open Access Journals (Sweden)

    Murat KUL

    2014-07-01

    Full Text Available The purpose of the study , candidates who participated in a special aptitude test of Physical Education and Sports School are compared those who were eligible to register with the win of Multiple Inte lligence Areas. In the research Scan model was used. Within the investigation, in 785 candidates who applied Bartin Universty School of Physical Education and Sports Special Ability Test for 2013 - 2014 academic year, 536 volunteer candidates who have average age x yaş = 21.15± 2.66 constitude. As data collection tool, belogns to the candidates personal information form and “Multiple Intelligences Inventory” which was developed by Özden (2003 for he identification of multiple intellegences was applied. Reliability coefficient was discovered as .96. In evaluation of data, SPSS data an alysis program was used. In evaluation of data, frequency, average, standard, deviation from descriptive statistical techniques was used. Also by taking into account normal distribution of the data, Independent Sample T - test of statistical techniques was u sed. In considering the findings of the study “Bodily - Kinesthetic Intelligence” which is a field of Multiple Intelligences of candidates as statistically significant diffirence was found in the area. Candidates winning higher than avarage scores candidates who can not win are seen to have. Also, “Social - Interpersonal Intelligence” of candidates qualifing to register with who can not qualify to register statistically significant results were observed in the levels. Winning candidates in this area compared t o the candidates who win more than others, it is concluded that they carry the dominant features. As a result of “Verbal - Linguistic Intelligence”, “Logical - Mathematical Intelligence”, “Musical - Rhythmic Intelligence”, “Bodily - Kinesthetic Intelligence, “Soci al - Interpersonal Intelligence” of Multiple Intelligence Areas candidates who participated in Physical Education

  2. Academic Dishonesty Tendencies and Values of Teacher Candidates

    OpenAIRE

    Ayşegül KADI; Osman Ferda BEYTEKİN; Hasan ARSLAN

    2016-01-01

    The purpose of this study was to examine the values and academic dishonesty tendencies of teacher candidates. The population of this study included teacher candidates who received pedagogic formation education during 2013-2014 academic semester at the Faculty of Education at Ege University. The study was conducted with 244 teacher candidates, who were chosen through convenient sampling method. Academic Dishonesty Tendency Scale and Portrait Values Questionnaire were used to collect data. It w...

  3. Physical education candidate teachers' beliefs about vocational self-esteem

    OpenAIRE

    CANPOLAT, A.; OZSAKER, Murat

    2014-01-01

    The purpose of this study was to determine epistemological belief and vocational self-esteem physical education candidate teachers of Physical Education and Sports Department in 3 different universities, and also to examine effect of epistemological beliefs on vocational self-esteem. A total of 346 candidate teacher respondents (137 female and 209 male) participated in the study. Epistemological Beliefs and Vocational Self-Esteem Scale were used to determine candidate teachers’ epistemologica...

  4. 32 CFR 901.6 - Candidate fitness test requirement.

    Science.gov (United States)

    2010-07-01

    ... Director of Athletics if a candidate's participation in high school athletics conflicts with test... TRAINING AND SCHOOLS APPOINTMENT TO THE UNITED STATES AIR FORCE ACADEMY Appointment Policies and...

  5. A Thermote, a Novel Thermal Element Simplifying the Finding of a Medium's Entropy Emerges as a Sensible Dark Matter Candidate from Primordial Black Holes with a Mass in Range of Axion's, a Leading Candidate

    Science.gov (United States)

    Feria, Erlan H.

    2017-06-01

    Black holes acting as dark matter have been predicted, e.g., via a duality theory in (Feria 2011, Proc. IEEE Int’l Conf. on SMC, Alaska, USA) and via observations in (Kashlinsky 2016, AJL). Here a thermote, a novel thermal element simplifying the finding of a medium’s entropy, emerges as a dark matter candidate from primordial black holes with a mass in range of axion's, a leading candidate. The thermote energy, eT, is defined as the average thermal energy contributed to a particle’s motion by the medium’s degrees of freedom (DoF) and is thus given by eT=NDoFkBT/2 where NDoF is the DoF number (e.g., NDoF=2 for a black-hole since only in its event-horizon particle motions can occur) and kBT/2 is the thermal energy contributed by each degree of freedom (kB is the Boltzmann constant and T is temperature). The entropy S of a spherical homogeneous medium is then simply stated as S=(kB/2)E/eT where E=Mc2 is the medium's rest-energy, with M its point-mass and c the speed of light, and eT=NDoFkBT/2 is the thermote's kinetic-energy. This simple equation naturally surfaced from a rest/kinetic or retention/motion mass-energy duality theory where, e.g., black-holes and vacuums form together such a duality with black holes offering the least resistance to mass-energy rest, or retention, and vacuums offering the least resistance to mass-energy kinetics, or motions. In turn, this duality theory has roots in the universal cybernetics duality principle (UCDP) stating “synergistic physical and mathematical dualities arise in efficient system designs” (Feria 2014, http://dx.doi.org/10.1117/2.1201407.005429, SPIE Newsroom). Our thermote based entropy finding method is applicable to spherical homogeneous mediums such as black-holes, photon-gases, and flexible-phase (Feria 2016, Proc. IEEE Int’l Conf. on Smart Cloud, Columbia University, NY, USA), where the thermote of a primordial black hole, with NDoF=2 and a CMB radiation temperature of T=2.725 kelvin, emerges as a

  6. Corrosion resistance of candidate transportation container materials

    International Nuclear Information System (INIS)

    Maestas, L.M.; Sorensen, N.R.; McAllaster, M.E.

    1995-01-01

    The Department of Energy is currently remediating several sites that have been contaminated over the years with hazardous, mixed waste and radioactive materials. Regulatory guidelines require strict compliance demonstrating public safety during remediation and the transport of these hazardous, mixed waste and radioactive materials. The compatibility of the metallic transportation containers with the contents they are designed to transport is an ultimate concern that must be satisfied to ensure public safety. The transportation issue is inherently complicated due to the complex, varied, and unknown composition of the hazardous, mixed and radioactive waste that is being, considered for transport by the DOE facilities. Never before have the interactions between the waste being transported and the materials that comprise the transportation packages been more important. Therefore, evaluation of material performance when subjected to a simulated waste will ensure that all regulatory issues and requirements for transportation of hazardous, mixed, and radioactive wastes are satisfied. The tasks encompassed by this study include defining criteria for candidate material selection, defining a test matrix that will provide pertinent information on the material compatibility with the waste stimulant, and evaluation of material performance when subjected to a stimulant waste. Our goal is to provide package design engineers with a choice of materials which exhibit enhanced performance upon exposure to hazardous, mixed, and radioactive waste that is similar in composition to the waste stimulant used in this study. Due to the fact that there are many other possible waste compositions, additional work needs to be done to broaden our materials compatibility/waste stream data base

  7. Investigation of Turkish Teacher Candidates Listening Skills

    Science.gov (United States)

    Karagöz, Beytullah; Iscan, Adem; Baskin, Sami; Irsi, Aysegül

    2017-01-01

    As a basic skill of language, listening is an essential process at interpretation surroundings. Today listening is necessary in many cases such as school life, interfamilial communication, etc. Thanks to listening, people acquire comprehension skills and expressing themselves in all areas. 2005 and 2015 Turkish Course Syllabus include special…

  8. Prediction of Waitlist Mortality in Adult Heart Transplant Candidates: The Candidate Risk Score.

    Science.gov (United States)

    Jasseron, Carine; Legeai, Camille; Jacquelinet, Christian; Leprince, Pascal; Cantrelle, Christelle; Audry, Benoît; Porcher, Raphael; Bastien, Olivier; Dorent, Richard

    2017-09-01

    The cardiac allocation system in France is currently based on urgency and geography. Medical urgency is defined by therapies without considering objective patient mortality risk factors. This study aimed to develop a waitlist mortality risk score from commonly available candidate variables. The study included all patients, aged 16 years or older, registered on the national registry CRISTAL for first single-organ heart transplantation between January 2010 and December 2014. This population was randomly divided in a 2:1 ratio into derivation and validation cohorts. The association of variables at listing with 1-year waitlist death or delisting for worsening medical condition was assessed within the derivation cohort. The predictors were used to generate a candidate risk score (CRS). Validation of the CRS was performed in the validation cohort. Concordance probability estimation (CPE) was used to evaluate the discriminative capacity of the models. During the study period, 2333 patients were newly listed. The derivation (n =1 555) and the validation cohorts (n = 778) were similar. Short-term mechanical circulatory support, natriuretic peptide decile, glomerular filtration rate, and total bilirubin level were included in a simplified model and incorporated into the score. The Concordance probability estimation of the CRS was 0.73 in the derivation cohort and 0.71 in the validation cohort. The correlation between observed and expected 1-year waitlist mortality in the validation cohort was 0.87. The candidate risk score provides an accurate objective prediction of waitlist mortality. It is currently being used to develop a modified cardiac allocation system in France.

  9. Zero-gravity cloud physics laboratory: Candidate experiments definition and preliminary concept studies

    Science.gov (United States)

    Eaton, L. R.; Greco, R. V.; Hollinden, A. B.

    1973-01-01

    The candidate definition studies on the zero-g cloud physics laboratory are covered. This laboratory will be an independent self-contained shuttle sortie payload. Several critical technology areas have been identified and studied to assure proper consideration in terms of engineering requirements for the final design. Areas include chambers, gas and particle generators, environmental controls, motion controls, change controls, observational techniques, and composition controls. This unique laboratory will allow studies to be performed without mechanical, aerodynamics, electrical, or other type techniques to support the object under study. This report also covers the candidate experiment definitions, chambers and experiment classes, laboratory concepts and plans, special supporting studies, early flight opportunities and payload planning data for overall shuttle payload requirements assessments.

  10. Unsupervised Spatio-Temporal Data Mining Framework for Burned Area Mapping

    Science.gov (United States)

    Boriah, Shyam (Inventor); Kumar, Vipin (Inventor); Mithal, Varun (Inventor); Khandelwal, Ankush (Inventor)

    2016-01-01

    A method reduces processing time required to identify locations burned by fire by receiving a feature value for each pixel in an image, each pixel representing a sub-area of a location. Pixels are then grouped based on similarities of the feature values to form candidate burn events. For each candidate burn event, a probability that the candidate burn event is a true burn event is determined based on at least one further feature value for each pixel in the candidate burn event. Candidate burn events that have a probability below a threshold are removed from further consideration as burn events to produce a set of remaining candidate burn events.

  11. Anchorage Areas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — An anchorage area is a place where boats and ships can safely drop anchor. These areas are created in navigable waterways when ships and vessels require them for...

  12. Assessment of candidate sites for disposal of treated effluents at the Hanford Site, Washington

    International Nuclear Information System (INIS)

    Davis, J.D.

    1992-01-01

    A rigidly defined evaluation process was used to recommend a preferred location to dispose of treated effluents from facilities in the 200 Areas of the US Department of Energy's Hanford Site in Washington State. First, siting constraints were defined based on functional design considerations and siting guidelines. Then, criteria for selecting a preferred site from among several candidates were identified and their relative importance defined. Finally, the weighted criteria were applied and a site was selected for detailed characterization by subsurface investigations

  13. Teacher Candidate Mental Health and Mental Health Literacy

    Science.gov (United States)

    Dods, Jennifer

    2016-01-01

    Providing teacher candidates with a strong foundation in mental health literacy during their teacher education program is crucial in ensuring novice teachers are prepared to support the mental health needs of their students. In addition to responding to students, teacher candidates are typically at an age when mental health disorders are common…

  14. Elections, Private Information, and State-Dependent Candidate Quality

    DEFF Research Database (Denmark)

    Jensen, Thomas

    is that candidate quality is state-dependent. Our main insight is that if the electorate is sufficiently well informed then there exists an equilibrium where the candidates' policy positions reveal their information and the policy outcome is the same as it would be if voters were fully informed (the median policy...

  15. Investigating Academic Achievements and Critical Thinking Dispositions of Teacher Candidates

    Science.gov (United States)

    Karagöl, Ibrahim; Bekmezci, Sinan

    2015-01-01

    The aim of this study is to examine the relationship between academic achievements and critical thinking dispositions of teacher candidates in Faculty of Education and to find out whether critical thinking dispositions and academic achievements scores of teacher candidates differ according to different variables. The population consists of the…

  16. Selecting candidate predictor variables for the modelling of post ...

    African Journals Online (AJOL)

    Selecting candidate predictor variables for the modelling of post-discharge mortality from sepsis: a protocol development project. Afri. Health Sci. .... Initial list of candidate predictor variables, N=17. Clinical. Laboratory. Social/Demographic. Vital signs (HR, RR, BP, T). Hemoglobin. Age. Oxygen saturation. Blood culture. Sex.

  17. Candidate genes for drought tolerance and improved productivity in ...

    Indian Academy of Sciences (India)

    Polymerase chain reaction (PCR) performed on 10 diverse cultivars that involved Japonica, Indica and local accessions, revealed 12 polymorphic candidate genes. Seven polymorphic candidate genes were then utilized to genotype 148 individuals of CT9993 × IR62266 doubled haploid (DH) mapping population.

  18. 29 CFR 452.46 - Characteristics of candidate.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Characteristics of candidate. 452.46 Section 452.46 Labor... DISCLOSURE ACT OF 1959 Candidacy for Office; Reasonable Qualifications § 452.46 Characteristics of candidate... of personal characteristics which have a direct bearing on fitness for union office. A union may, for...

  19. Web tools for the prioritization of candidate disease genes.

    NARCIS (Netherlands)

    Oti, M.O.; Ballouz, S.; Wouters, M.A.

    2011-01-01

    Despite increasing sequencing capacity, genetic disease investigation still frequently results in the identification of loci containing multiple candidate disease genes that need to be tested for involvement in the disease. This process can be expedited by prioritizing the candidates prior to

  20. Undergraduate Teacher Candidate Perceptions Integrating Technology in Classroom Instruction

    Science.gov (United States)

    Anderson, Charlise Askew

    2016-01-01

    The purpose of this study was to analyze undergraduate teacher candidates' perceptions on integrating technology in the classroom. The study was embedded in the "Technology Pedagogical Content Knowledge" theoretical model. A sample of 143 undergraduate teacher candidates participated in the study. They were asked to address items on a…

  1. 32 CFR 903.8 - Cadet candidate disenrollment.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Cadet candidate disenrollment. 903.8 Section 903.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE MILITARY TRAINING AND SCHOOLS AIR FORCE ACADEMY PREPARATORY SCHOOL § 903.8 Cadet candidate disenrollment. (a) In...

  2. Elections, Information, and State-Dependent Candidate Quality

    DEFF Research Database (Denmark)

    Jensen, Thomas

    The quality of political candidates often depends on the current state of the world, for example because their personal characteristics are more valuable in some situations than in others. We explore the implications of state-dependent candidate quality in a model of electoral competition where...

  3. University Offer Rates for Candidates from Different Ethnic Categories

    Science.gov (United States)

    Noden, Philip; Shiner, Michael; Modood, Tariq

    2014-01-01

    Previous research suggested that candidates from some black and minority ethnic groups were less likely to receive an offer of a place from an "old" university. These findings were disputed in a re-analysis carried out for HEFCE which found that only Pakistani candidates were significantly less likely to receive offers (from both…

  4. Class Teacher Candidates' Opinions on Genetically Modified Organisms (GMO)

    Science.gov (United States)

    Ural Keles, Pinar; Aydin, Suleyman

    2017-01-01

    This study was conducted to determine the Class teacher candidates' opinions on Genetically Modified Organisms. The study was carried out with 101 teacher candidates who were studying in the 3rd grade of Agri Ibrahim Çeçen University Classroom Teacher Department in 2016-2017 academic year. Of the students who participated in the survey, 56 were…

  5. Academic Dishonesty Tendencies and Values of Teacher Candidates

    Directory of Open Access Journals (Sweden)

    Ayşegül KADI

    2016-12-01

    Full Text Available The purpose of this study was to examine the values and academic dishonesty tendencies of teacher candidates. The population of this study included teacher candidates who received pedagogic formation education during 2013-2014 academic semester at the Faculty of Education at Ege University. The study was conducted with 244 teacher candidates, who were chosen through convenient sampling method. Academic Dishonesty Tendency Scale and Portrait Values Questionnaire were used to collect data. It was a correlational study due to the investigation of the relationship between values and academic dishonesty tendencies of teacher candidates. It was also a survey study since the academic dishonesty tendencies and values of teacher candidates were examined in relation to demographic variables. The results suggested that there wass a significant difference between the values and academic dishonesty tendencies of teacher candidates for gender variable. The values and academic dishonesty tendencies of teacher candidates did not differ for different fields of study. There was not a significant relationship between the academic dishonesty tendencies and values of teacher candidates.

  6. Five kepler target stars that show multiple transiting exoplanet candidates

    DEFF Research Database (Denmark)

    Steffen..[], Jason H.; Batalha, N. M.; Broucki, W J.

    2010-01-01

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets...

  7. Measuring College Success for International Baccalaureate Diploma and Certificate Candidates

    Science.gov (United States)

    Hill, Jennifer Coles

    2018-01-01

    This quantitative study was conducted at a private international high school. The study purpose was to investigate United States college trends comparing International Baccalaureate Diploma Program candidates and International Baccalaureate Non-Diploma Program candidates from the same school in Asia. Data was collected for the Classes of 2007-2012…

  8. Social Studies Teacher Candidates' Views on Historical Thinking Skills

    Science.gov (United States)

    Ozmen, Cengiz

    2015-01-01

    Current study aimed to present Social Studies teacher candidates' views on historical thinking skills. Study was conducted using qualitative design and working group was composed of a total of 121 teacher candidates (62 females and 59 males) attending Social Studies Teaching Department of Karadeniz Technical University and Adiyaman University…

  9. Searching for Be star candidates within large databases

    Directory of Open Access Journals (Sweden)

    Sabogal Beatriz

    2017-01-01

    Full Text Available Long time surveys yield many light curves among their byproducts, useful to identify candidate Be stars that can be confirmed by spectroscopic follow-ups. We present in this work different techniques we have used to find Be star candidates in the Galaxy, the Magellanic Clouds and the OGLE-IV Gaia South Ecliptic Pole Field.

  10. Candidate Political Philosophy: Revelations in the 1960 and 1976 Debates.

    Science.gov (United States)

    Meadow, Robert G.; Jackson-Beeck, Marilyn

    Since voters rarely have access to a candidate's unexpurgated statements, they rely on political advertising, film footage, and media interpretations. Thus, their expectations of candidates generally reflect selective reporting and self-aggrandizement. A framework for researching the degree of understanding reached between politicians and the…

  11. Holmes versus Traditional Teacher Candidates: Labor Market Receptivity.

    Science.gov (United States)

    Young, I. Phillip; And Others

    1997-01-01

    "Typical" paper credentials were used to create 12 hypothetical teacher candidates. Credential contents were varied to reflect all combinations of college preparatory institutions (Holmes vs. traditional), education degree types, and chronological ages. Randomly selected high school principals then evaluated candidates. Holmes-prepared…

  12. Identification of Schistosoma mansoni candidate antigens for diagnosis of schistosomiasis

    Directory of Open Access Journals (Sweden)

    Gardenia Braz Figueiredo Carvalho

    2011-11-01

    Full Text Available The development of a more sensitive diagnostic test for schistosomiasis is needed to overcome the limitations of the use of stool examination in low endemic areas. Using parasite antigens in enzyme linked immunosorbent assay is a promising strategy, however a more rational selection of parasite antigens is necessary. In this study we performed in silico analysis of the Schistosoma mansoni genome, using SchistoDB database and bioinformatic tools for screening immunogenic antigens. Based on evidence of expression in all parasite life stage within the definitive host, extracellular or plasmatic membrane localization, low similarity to human and other helminthic proteins and presence of predicted B cell epitopes, six candidates were selected: a glycosylphosphatidylinositol-anchored 200 kDa protein, two putative cytochrome oxidase subunits, two expressed proteins and one hypothetical protein. The recognition in unidimensional and bidimensional Western blot of protein with similar molecular weight and isoelectric point to the selected antigens by sera from S. mansoni infected mice indicate a good correlation between these two approaches in selecting immunogenic proteins.

  13. Regional hydrogeological simulations. Numerical modelling using ConnectFlow. Preliminary site description Simpevarp sub area - version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Hartley, Lee; Hoch, Andrew; Hunter, Fiona; Jackson, Peter [Serco Assurance, Risley (United Kingdom); Marsic, Niko [Kemakta Konsult, Stockholm (Sweden)

    2005-02-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) carries out site investigations in two different candidate areas in Sweden with the objective of describing the in situ conditions for a bedrock repository for spent nuclear fuel. The two candidate areas are named Forsmark and Simpevarp. The site characterisation work is divided into two phases, an initial site investigation phase (IPLU) and a complete site investigation phase (KPLU). The results of IPLU are used as a basis for deciding on a subsequent KPLU phase. On the basis of the KPLU investigations a decision is made as to whether detailed characterisation will be performed (including sinking of a shaft).An integrated component in the site characterisation work is the development of site descriptive models. These comprise basic models in three dimensions with an accompanying text description. Central in the modelling work is the geological model which provides the geometrical context in terms of a model of deformation zones and the rock mass between the zones. Using the geological and geometrical description models as a basis, descriptive models for other geo-disciplines (hydrogeology, hydro-geochemistry, rock mechanics, thermal properties and transport properties) will be developed. Great care is taken to arrive at a general consistency in the description of the various models and assessment of uncertainty and possible needs of alternative models.Here, a numerical model is developed on a regional-scale (hundreds of square kilometres) to understand the zone of influence for groundwater flow that effects the Simpevarp area. Transport calculations are then performed by particle tracking from a local-scale release area (tens of square kilometres) to identify potential discharge areas for the site. The transport from the two site-scale release areas (a few square kilometres) at the Simpevarp site and the Laxemar site are also considered more specifically and using greater grid resolution.The main

  14. ECONOMIC GROWTH IN SOUTH EASTERN EUROPE: AN INVESTIGATION FOR SIX EU CANDIDATE AND POTENTIAL CANDIDATE COUNTRIES

    Directory of Open Access Journals (Sweden)

    Ileana Tache

    2017-08-01

    Full Text Available The South Eastern European region (SEE has seen major beneficial transformation in the recent years. Romania and Bulgaria in 2007 and Croatia in 2013 became members of the European Union and registered significant economic growth rates. This paper investigates some important factors that influence economic growth in 6 EU candidate and potential candidate countries (Albania, Bosnia and Herzegovina, Kosovo, Former Yugoslav Republic of Macedonia, Montenegro and Serbia and offers to policy makers in those countries key insights for stimulating the economy. The paper proposes a dynamic growth model which will be developed using the Quasi-maximum likelihood (QML estimation. This model is suited for this type of analysis because of the small T sample and also to cope with missingness. The results indicate that nine out of the fourteen variables were statistically significant. The number of non-resident tourists, the number of passenger cars, the number of children in pre-primary and primary-education are positive factors for economic growth. In contrast, government debt, inflation, all energy imports, railway transportation and primary production of coal and lignite are hindering development.

  15. Focus Area Science Technology Summer Fellowship (FAST-SF)

    Indian Academy of Sciences (India)

    REGISTRATIONS CLOSED. Announcement of selected candidates will commence towards the end of February. Focus Area Science Technology Summer Fellowship (FAST-SF). REGISTRATIONS CLOSED. Announcement of selected candidates will commence towards the end of February. Associates – 2017. Posted on ...

  16. Ecological criteria for evaluating candidate sites for marine reserves

    Science.gov (United States)

    Roberts, Callum M.; Andelman, Sandy; Branch, George; Bustamante, Rodrigo H.; Castilla, Juan Carlos; Dugan, Jenifer; Halpern, Benjamin S.; Lafferty, Kevin D.; Leslie, Heather; Lubchenco, Jane; McArdle, Deborah; Possingham, Hugh P.; Ruckelshaus, Mary; Warner, Robert R.

    2003-01-01

    Several schemes have been developed to help select the locations of marine reserves. All of them combine social, economic, and biological criteria, and few offer any guidance as to how to prioritize among the criteria identified. This can imply that the relative weights given to different criteria are unimportant. Where two sites are of equal value ecologically, then socioeconomic criteria should dominate the choice of which should be protected. However, in many cases, socioeconomic criteria are given equal or greater weight than ecological considerations in the choice of sites. This can lead to selection of reserves with little biological value that fail to meet many of the desired objectives. To avoid such a possibility, we develop a series of criteria that allow preliminary evaluation of candidate sites according to their relative biological values in advance of the application of socioeconomic criteria. We include criteria that, while not strictly biological, have a strong influence on the species present or ecological processes. Our scheme enables sites to be assessed according to their biodiversity, the processes which underpin that diversity, and the processes that support fisheries and provide a spectrum of other services important to people. Criteria that capture biodiversity values include biogeographic representation, habitat representation and heterogeneity, and presence of species or populations of special interest (e.g., threatened species). Criteria that capture sustainability of biodiversity and fishery values include the size of reserves necessary to protect viable habitats, presence of exploitable species, vulnerable life stages, connectivity among reserves, links among ecosystems, and provision of ecosystem services to people. Criteria measuring human and natural threats enable candidate sites to be eliminated from consideration if risks are too great, but also help prioritize among sites where threats can be mitigated by protection. While our

  17. Infrared study of new star cluster candidates associated to dusty globules

    Science.gov (United States)

    Soto King, P.; Barbá, R.; Roman-Lopes, A.; Jaque, M.; Firpo, V.; Nilo, J. L.; Soto, M.; Minniti, D.

    2014-10-01

    We present results from a study of a sample of small star clusters associated to dusty globules and bright-rimmed clouds that have been observed under ESO/Chile public infrared survey Vista Variables in the Vía Láctea (VVV). In this short communication, we analyse the near-infrared properties of a set of four small clusters candidates associated to dark clouds. This sample of clusters associated to dusty globules are selected from the new VVV stellar cluster candidates developed by members of La Serena VVV Group (Barbá et al. 2014). Firstly, we are producing color-color and color-magnitude diagrams for both, cluster candidates and surrounding areas for comparison through PSF photometry. The cluster positions are determined from the morphology on the images and also from the comparison of the observed luminosity function for the cluster candidates and the surrounding star fields. Now, we are working in the procedures to establish the full sample of clusters to be analyzed and methods for subtraction of the star field contamination. These clusters associated to dusty globules are simple laboratories to study the star formation relatively free of the influence of large star-forming regions and populous clusters, and they will be compared with those clusters associated to bright-rimmed globules, which are influenced by the energetic action of nearby O and B massive stars.

  18. Test for positional candidate genes for body composition on pig chromosome 6

    Directory of Open Access Journals (Sweden)

    Pérez-Enciso Miguel

    2002-07-01

    Full Text Available Abstract One QTL affecting backfat thickness (BF, intramuscular fat content (IMF and eye muscle area (MA was previously localized on porcine chromosome 6 in an F2 cross between Iberian and Landrace pigs. This work was done to study the effect of two positional candidate genes on these traits: H-FABP and LEPR genes. The QTL mapping analysis was repeated with a regression method using genotypes for seven microsatellites and two PCR-RFLPs in the H-FABP and LEPR genes. H-FABP and LEPR genes were located at 85.4 and 107 cM respectively, by linkage analysis. The effects of the candidate gene polymorphisms were analyzed in two ways. When an animal model was fitted, both genes showed significant effects on fatness traits, the H-FABP polymorphism showed significant effects on IMF and MA, and the LEPR polymorphism on BF and IMF. But when the candidate gene effect was included in a QTL regression analysis these associations were not observed, suggesting that they must not be the causal mutations responsible for the effects found. Differences in the results of both analyses showed the inadequacy of the animal model approach for the evaluation of positional candidate genes in populations with linkage disequilibrium, when the probabilities of the parental origin of the QTL alleles are not included in the model.

  19. Real convergence and determinants of growth in EU candidate and potential candidate countries: a panel data approach

    Czech Academy of Sciences Publication Activity Database

    Morgese Borys, Magdalena; Polgár, É. K.; Zlate, A.

    -, č. 86 (2008), s. 1-46 ISSN 1607-1484 Institutional research plan: CEZ:AV0Z70850503 Keywords : EU candidate and potential candidate countries * real convergence * determinants of growth Subject RIV: AH - Economics http://www.ecb.europa.eu/pub/pdf/scpops/ecbocp86.pdf

  20. Disease candidate gene identification and prioritization using protein interaction networks

    Directory of Open Access Journals (Sweden)

    Aronow Bruce J

    2009-02-01

    Full Text Available Abstract Background Although most of the current disease candidate gene identification and prioritization methods depend on functional annotations, the coverage of the gene functional annotations is a limiting factor. In the current study, we describe a candidate gene prioritization method that is entirely based on protein-protein interaction network (PPIN analyses. Results For the first time, extended versions of the PageRank and HITS algorithms, and the K-Step Markov method are applied to prioritize disease candidate genes in a training-test schema. Using a list of known disease-related genes from our earlier study as a training set ("seeds", and the rest of the known genes as a test list, we perform large-scale cross validation to rank the candidate genes and also evaluate and compare the performance of our approach. Under appropriate settings – for example, a back probability of 0.3 for PageRank with Priors and HITS with Priors, and step size 6 for K-Step Markov method – the three methods achieved a comparable AUC value, suggesting a similar performance. Conclusion Even though network-based methods are generally not as effective as integrated functional annotation-based methods for disease candidate gene prioritization, in a one-to-one comparison, PPIN-based candidate gene prioritization performs better than all other gene features or annotations. Additionally, we demonstrate that methods used for studying both social and Web networks can be successfully used for disease candidate gene prioritization.

  1. A CATALOG OF MOVING GROUP CANDIDATES IN THE SOLAR NEIGHBORHOOD

    International Nuclear Information System (INIS)

    Zhao Jingkun; Zhao Gang; Chen Yuqin

    2009-01-01

    Based on the kernel estimator and wavelet technique, we have identified 22 moving group candidates in the solar neighborhood from a sample which includes around 14,000 dwarfs and 6000 giants. Six of them were previously known as the Hercules stream, the Sirus-UMa stream, the Hyades stream, the Caster group, the Pleiades stream, and the IC 2391; five of them have also been reported by other authors. 11 moving group candidates, not previously reported in the literature, show prominent structures in dwarf or giant samples. A catalog of moving group candidates in the solar neighborhood is presented in this work.

  2. COMPARATIVE EFFECTIVENESS OF DIFFERENT METHODS OF CANDIDAL DYSBACTERIOSIS THERAPY

    Directory of Open Access Journals (Sweden)

    S.V. Nikolaeva

    2009-01-01

    Full Text Available The study of effectiveness of different methods of microbiological disorders correction in children after 3 years old with candidal dysbacteriosis are presented in this article. The study compared probiotical sour milk-made stuff («Actimel» and sour milk-made stuff, not fortified with probiotical cultures («Rastishka» and traditional kefir. It was shown that an inclusion of probiotical sour milkmade stuff in diet of children with candidal dysbacteriosis results in normalization of lacto- and bifidobacteria level and decreasing of Candida level.Key words: children, candidal dysbacteriosis, probiotics.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(6:31-35

  3. Typology of electoral candidates. Case study: Sorin Oprescu

    Directory of Open Access Journals (Sweden)

    Coman, C.

    2011-01-01

    Full Text Available By applying the content analysis technique of communication andby using analysis patterns such as the theory of rational choices, thedramaturgical model, the attraction model, the transactional analysis, this study identifies 4 typical categories of candidates to Romania’s presidency(elitist, dominating, reactive, sociable. In the analysis of the electoral itinerary of candidate Sorin Oprescu there are considered aspects such as identity, symbolism, volunteering, propagandas and media exposure, in order to make a SWOT analysis, thus facilitating the understanding of the candidate failure within the election process.

  4. Psychological profile of Taiwanese female cosmetic surgery candidates: understanding their motivation for cosmetic surgery.

    Science.gov (United States)

    Chen, Hung-Chi; Karri, Vasu; Yu, Rwei-Ling; Chung, Kuo-Piao; Lu, Yi-Tien; Yang, Ming-Chin

    2010-06-01

    Psychological processes consisting of body image and self-esteem are considered key to the motivation for cosmetic surgery (CS). The current study aimed to investigate such processes as well as social support, perception of other people's opinion, and sex life satisfaction of Taiwanese female CS candidates. Further analyses were conducted to identify which processes predicted motivation for CS. Questionnaires comprising subscales of the Multidimensional Body-Self Relations Questionnaire, the Rosenberg Self-Esteem Scale, the Perception of Other Peoples' Opinion Scale, and social support and sex life questions were completed by Taiwanese female CS candidates (n = 85) preoperatively. The results were compared with those for a sex-matched nonsurgical control group (n = 105) as well as previously published data and reference norms. Correlation and multiple regression analysis also was conducted to identify any relationship between variables as well as which variable best predicted the likelihood of a patient having surgery. A total of 29 CS candidates (34.1%) reported before their surgical consultation that they would "very likely" or "likely" have CS, and 54 (63.5%) received support from all three social groups, namely, family, friends, and partner. The body image (appearance evaluation, orientation, and body area satisfaction) of the CS candidates was not significantly different from that of the control group. The former had significantly higher self-esteem and perception of other people's opinion scores. Self-esteem was positively correlated with appearance evaluation (r = 0.484; p self-esteem of the CS candidates opposes the view that low self-esteem is a principal motivating factor for CS.

  5. Party and candidate websites: A comparative explanatory analysis

    NARCIS (Netherlands)

    Kruikemeier, S.; Aparaschivei, A.P.; Boomgaarden, H.G.; van Noort, G.; Vliegenthart, R.

    2015-01-01

    This study provides a systematic investigation of party and candidate websites across five countries. It examines three prominent features of current online political communication (interactivity, political personalization, and mobilization). Furthermore it assesses to what extent country, party,

  6. How political candidates use Twitter and the impact on votes

    NARCIS (Netherlands)

    Kruikemeier, S.

    2014-01-01

    This study investigates the content characteristics of Twitter during an election campaign, and the relationship between candidates’ style of online campaigning (i.e., politically personalized and interactive communication) and electoral support for those candidates. Thereby, it provides a better

  7. Human Health Safety Evaluation of Halon Replacement Candidates

    National Research Council Canada - National Science Library

    Dodd, D. E; Jepson, G. W; Macko, Jr, J. A

    2000-01-01

    .... The services within the Department of Defense (DoD) are directed to determine and evaluate suitable halon replacement candidates that will optimize performance of mission-essential equipment and operations...

  8. Update on the Clinical Development of Candidate Malaria Vaccines

    National Research Council Canada - National Science Library

    Ballou, W. R; Arevalo-Herrera, Myriam; Carucci, Daniel; Richie, Thomas L; Corradin, Giampietro; Diggs, Carter; Druilhe, Pierre; Giersing, Birgitte K; Saul, Allan; Heppner, D. G

    2004-01-01

    ... powerful driver for stimulating clinical development of candidate vaccines for malaria. This new way forward promises to greatly increase the likelihood of bringing a safe and effective vaccine to licensure...

  9. On security arguments of the second round SHA-3 candidates

    DEFF Research Database (Denmark)

    Andreeva, Elena; Bogdanov, Andrey; Mennink, Bart

    2012-01-01

    of which got accepted to the first round. 14 candidates were left in the second round, out of which five candidates have been recently chosen for the final round. An important criterion in the selection process is the SHA-3 hash function security. We identify two important classes of security arguments...... for the new designs: (1) the possible reductions of the hash function security to the security of its underlying building blocks and (2) arguments against differential attack on building blocks. In this paper, we compare the state of the art provable security reductions for the second round candidates...... and review arguments and bounds against classes of differential attacks.We discuss all the SHA-3 candidates at a high functional level, analyze, and summarize the security reduction results and bounds against differential attacks. Additionally, we generalize the well-known proof of collision resistance...

  10. Campaigning on the Internet: 2008 Presidential General Election Candidate Webpage

    Directory of Open Access Journals (Sweden)

    William L. Benoit

    2016-12-01

    Full Text Available The Internet is becoming an increasingly important component of political campaigns. This study employed content analysis to apply Functional Theory and Issue Ownership Theory to Obama’s and McCain’s presidential candidate webpages in the 2008 campaign. Acclaims (92% were more common than attacks (98%; defenses did not occur in this sample. Policy (82% was addressed more than character (18%. When discussing policy, these candidates addressed future plans most frequently, followed by general goals and then past deeds; on character, candidates discussed ideals, then personal qualities, and then leadership ability. This study shows that as candidates use the Internet to reach voters, their webpages conform to theoretical expectations.

  11. Official portrait of 1987 astronaut candidate Kevin P. Chilton

    Science.gov (United States)

    1987-01-01

    Official portrait of 1987 astronaut candidate Kevin P. Chilton. Chilton, a member of the United States Air Force and Astronaut Class 12, wears a navy blue flight suit and holds a space shuttle orbiter model.

  12. A Model Strategy and Policy for Screening Firefighter Candidates

    National Research Council Canada - National Science Library

    Pope, Christopher M

    2006-01-01

    ... and motivated by the desire to serve their community and country. Reasons for and evidence of the need for a new firefighter candidate screening strategy to support this new mission are addressed in this thesis...

  13. Intersectionality, Recruitment and Selection : Ethnic Minority Candidates in Dutch Parties

    NARCIS (Netherlands)

    Mügge, L.M.

    2016-01-01

    This article aims to contribute to explanations why ethnic minority women outnumber ethnic minority men in national parliaments of European immigration countries. Extending the intersectional lens it asks: which ethnic minority candidates are recruited and selected? Drawing on nine elections

  14. 22 CFR 11.30 - Senior Foreign Service officer career candidate and limited non-career appointments.

    Science.gov (United States)

    2010-04-01

    ... in foreign languages, and/or their aptitude for learning them. Senior Career Candidates will be... leadership qualities, and highly developed functional, foreign language, and area expertise.” (iii) Grading..., under the procedures of the prospective employing agency. (8) Foreign language requirement. Applicants...

  15. Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Devaux Yvan

    2011-12-01

    Full Text Available Abstract Background Prediction of left ventricular (LV remodeling after acute myocardial infarction (MI is clinically important and would benefit from the discovery of new biomarkers. Methods Blood samples were obtained upon admission in patients with acute ST-elevation MI who underwent primary percutaneous coronary intervention. Messenger RNA was extracted from whole blood cells. LV function was evaluated by echocardiography at 4-months. Results In a test cohort of 32 MI patients, integrated analysis of microarrays with a network of protein-protein interactions identified subgroups of genes which predicted LV dysfunction (ejection fraction ≤ 40% with areas under the receiver operating characteristic curve (AUC above 0.80. Candidate genes included transforming growth factor beta receptor 1 (TGFBR1. In a validation cohort of 115 MI patients, TGBFR1 was up-regulated in patients with LV dysfunction (P Conclusions We identified TGFBR1 as a new candidate prognostic biomarker after acute MI.

  16. Supernova remnant candidates in the ROSAT All-Sky Survey

    Science.gov (United States)

    Prinz, T.; Becker, W.

    2014-07-01

    Radio supernova remnants (SNRs) in the Galaxy comprise an incomplete sample of the SNR population due to various selection effects. ROSAT performed the first All-Sky Survey (RASS) with an imaging X-ray telescope and thus provided another window for finding SNRs. Schaudel (2003) searched the RASS for unknown SNRs and pinpointed about 210 candidates. Meanwhile, 14 new SNRs of his list were identified (cf. Prinz & Becker 2013 for a summary). Revisiting the RASS SNR candidates and applying more stringent selection criteria as well as taking archival XMM-Newton, Chandra and Fermi data into account the current list of RASS SNR candidates still comprises 73 sources. These sources are promising SNR candidates and studying them with e.g. eRosita will help to reveal their true nature. eRosita is an X-ray telescope which is supposed to be launched in 2016. It will perform an X-ray all-sky survey with a sensitivity of more than 10 times of what was available with ROSAT. It supports to continue the previous SNR identification campaign and may reveal other candidates not seen with ROSAT. We report on the current status of our supernova identification campaign, characterize the most promising candidates and give prospects for eRosita.

  17. Thirty methods to destroy the creativity of psychoanalytic candidates.

    Science.gov (United States)

    Kernberg, O F

    1996-10-01

    The author explores formal aspects of psychoanalytic education relevant to the fostering or inhibiting of creativity in the work of candidates. He refers to thirty features of psychoanalytic institutes that inhibit candidates' creativity and, by implication, illustrate problems in psychoanalytic education that require our attention. These features include systematic slowing down of institutional progression of candidates, repetitive and unquestioning teaching of key papers by Freud, monolithic tendencies regarding theoretical approaches, isolation of candidates from the professional and scientific activities of the psychoanalytic society, accentuation of the hieratical relations among the psychoanalytic faculty, graduation rituals, discouragement of original contributions by candidates, intellectual isolation of institutes, lack of full presentation of clinical work by senior members of the faculty, neglect of studies of controversies regarding psychoanalytic technique, 'paranoiagenic' features of the relationship among faculty and regarding requirements for candidates, the 'convoy' system, neglect of exploration of the scientific and cultural boundaries and applications of psychoanalysis and the effects of institutional conflicts around the appointment of training analysts.

  18. Ensemble candidate classification for the LOTAAS pulsar survey

    Science.gov (United States)

    Tan, C. M.; Lyon, R. J.; Stappers, B. W.; Cooper, S.; Hessels, J. W. T.; Kondratiev, V. I.; Michilli, D.; Sanidas, S.

    2018-03-01

    One of the biggest challenges arising from modern large-scale pulsar surveys is the number of candidates generated. Here, we implemented several improvements to the machine learning (ML) classifier previously used by the LOFAR Tied-Array All-Sky Survey (LOTAAS) to look for new pulsars via filtering the candidates obtained during periodicity searches. To assist the ML algorithm, we have introduced new features which capture the frequency and time evolution of the signal and improved the signal-to-noise calculation accounting for broad profiles. We enhanced the ML classifier by including a third class characterizing RFI instances, allowing candidates arising from RFI to be isolated, reducing the false positive return rate. We also introduced a new training data set used by the ML algorithm that includes a large sample of pulsars misclassified by the previous classifier. Lastly, we developed an ensemble classifier comprised of five different Decision Trees. Taken together these updates improve the pulsar recall rate by 2.5 per cent, while also improving the ability to identify pulsars with wide pulse profiles, often misclassified by the previous classifier. The new ensemble classifier is also able to reduce the percentage of false positive candidates identified from each LOTAAS pointing from 2.5 per cent (˜500 candidates) to 1.1 per cent (˜220 candidates).

  19. Description of surface systems. Preliminary site description. Forsmark area Version 1.2

    International Nuclear Information System (INIS)

    Lindborg, Tobias

    2005-06-01

    Swedish Nuclear Fuel and Waste Management Co (SKB) started site investigations for a deep repository for spent nuclear fuel in 2002 at two different sites in Sweden, Forsmark and Oskarshamn. The investigations should provide necessary information for a license application aimed at starting underground exploration. For this reason, ecosystem data need to be interpreted and assessed into site descriptive models, which in turn are used for safety assessment studies and for environmental impact assessment. Descriptions of the surface system are also needed for further planning of the site investigations. This report describes the surface ecosystems of the Forsmark site (e.g. hydrology, Quaternary deposits, chemistry, vegetation, animals and the human land use). The ecosystem description is an integration of the site and its regional setting, covering the current state of the biosphere as well as the ongoing natural processes affecting the longterm development. Improving the descriptions is important during both the initial and the complete site investigation phase. Before starting of the initial phase in Forsmark, version 0 of the site descriptive model was developed. The results of the initial site investigation phase is compiled into a preliminary site description of Forsmark (version 1.2) in June 2005. This report provides the major input and background to the biosphere description, in the 1.2 version of the Forsmark site description. The basis for this interim version is quality-assured field data from the Forsmark sub area and regional area, available in the SKB SICADA, and GIS data bases as of July 31th 2004 as well as version 1.1 of the Site Descriptive Model. To achieve an ecosystem site description there is a need to develop discipline-specific models by interpreting and analysing primary data. The different discipline-specific models are then integrated into a system describing interactions and flows and stocks of matter between and within functional units in

  20. Description of surface systems. Preliminary site description. Forsmark area Version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Lindborg, Tobias (ed.)

    2005-06-01

    Swedish Nuclear Fuel and Waste Management Co (SKB) started site investigations for a deep repository for spent nuclear fuel in 2002 at two different sites in Sweden, Forsmark and Oskarshamn. The investigations should provide necessary information for a license application aimed at starting underground exploration. For this reason, ecosystem data need to be interpreted and assessed into site descriptive models, which in turn are used for safety assessment studies and for environmental impact assessment. Descriptions of the surface system are also needed for further planning of the site investigations. This report describes the surface ecosystems of the Forsmark site (e.g. hydrology, Quaternary deposits, chemistry, vegetation, animals and the human land use). The ecosystem description is an integration of the site and its regional setting, covering the current state of the biosphere as well as the ongoing natural processes affecting the longterm development. Improving the descriptions is important during both the initial and the complete site investigation phase. Before starting of the initial phase in Forsmark, version 0 of the site descriptive model was developed. The results of the initial site investigation phase is compiled into a preliminary site description of Forsmark (version 1.2) in June 2005. This report provides the major input and background to the biosphere description, in the 1.2 version of the Forsmark site description. The basis for this interim version is quality-assured field data from the Forsmark sub area and regional area, available in the SKB SICADA, and GIS data bases as of July 31th 2004 as well as version 1.1 of the Site Descriptive Model. To achieve an ecosystem site description there is a need to develop discipline-specific models by interpreting and analysing primary data. The different discipline-specific models are then integrated into a system describing interactions and flows and stocks of matter between and within functional units in

  1. Revitalization Areas

    Data.gov (United States)

    Department of Housing and Urban Development — Revitalization areas are HUD-designated neighborhoods in need of economic and community development and where there is already a strong commitment by the local...

  2. 700 Area

    Data.gov (United States)

    Federal Laboratory Consortium — The 700 Area of the Hanford Site is located in downtown Richland.Called the Federal Office Building, the Richland Operations Site Manager and the Richland Operations...

  3. Comments from the Swedish Society for Nature Conservation, SSNC, and the Swedish NGO office for Nuclear Waste Review, MKG, on the industry's, SKB, research programme Fud-07

    Energy Technology Data Exchange (ETDEWEB)

    2009-06-15

    instruct the Radiation Safety Authority to develop its own independent assessment tools and knowledge base for its assessment of the industry's presentation, in the forthcoming application documents, of alternative methods for storing high-level nuclear waste. - The Government needs to make it clear that both long-term environmental safety and the security risks that are imposed by possible deliberate or speculative violation of the repository poses weigh heavily in any evaluation of the various alternative methods for storage of high-level nuclear waste. - The Government must ensure that the Radiation Safety Authority continues to develop its own independent assessment tools and knowledge base for its evaluation of an inland location of the repository with respect to long term environmental safety. - The Government should alert the Radiation Safety Authority to the need to make sure that both collective radiation doses from diffuse sources and the impact of radiation on the entire eco-system are included in safety analyses. - The Government should make it clear to the industry, to local government and to other actors that long-term environmental safety is an overriding criterion that may not be compromised by hastening to a decision to establish a repository. - The Government should review and revise legislation in the area of radiation safety. - The Government should review and reorganize the administrative structure of social science research relating to nuclear waste management. - The Government should take measures to ensure that environmental organizations can receive funds out of the Swedish Nuclear Waste Fund also after 2008

  4. Evaluation of proteinuria in healthy living kidney donor candidates.

    Science.gov (United States)

    Leischner, M P; Naratadam, G O; Hou, S H; Singh, A K; Leehey, D J

    2006-11-01

    Evaluation of living kidney donor candidates includes careful assessment for the presence or absence of kidney disease. Kidney donation has been considered to be at least relatively contraindicated if urinary total protein excretion is above the normal range. However, at the present time, there is no uniformly accepted level of urine total protein excretion that would exclude donation. Albumin excretion instead of total protein excretion as a criterion has not previously been evaluated. This was a prospective observational study over a 3-year period in a single tertiary care center designed to assess current selection criteria for kidney donation with respect to urine total protein and albumin excretion. Twenty four percent (25 of 105) of healthy adult kidney donor candidates had elevated urinary total protein excretion rates (150 to 292 mg/24 h). Of these 105 candidates, 39 had simultaneous measurements of both urinary total protein and albumin. Although one-third (13/39) had elevated 24-hour urine total protein values, none had elevated urine albumin excretion. Measurement of albumin, the most common single protein found in urine, appears to be helpful in the evaluation of proteinuria in donor candidates. Many healthy adult kidney donor candidates have mildly elevated total protein excretion but normal albumin excretion. We believe that such patients should not be excluded from donation.

  5. Study of candidate genes for dyslexia in Brazilian individuals.

    Science.gov (United States)

    Svidnicki, M C C M; Salgado, C A; Lima, R F; Ciasca, S M; Secolin, R; Pomilio, M C A; Junqueira, P A; Pinto, M S; Pereira, M M; Sartorato, E L

    2013-11-07

    Dyslexia or reading disability (RD) is the most common childhood learning disorder and a significantly heritable trait. Many recent studies have investigated the genetic basis of dyslexia, and several candidate genes have been proposed. Among these, DCDC2 and KIAA0319 have emerged as the strongest candidate genes for dyslexia; however studies have not provided uniformly supportive results. The aim of this study was to assess the contribution of proposed candidate genes to the molecular etiology of dyslexia in a Brazilian sample. Large deletions and duplications in the candidate genes DCDC2, KIAA0319, and ROBO1 were investigated in 51 dyslexic subjects. Furthermore, a family-based association study was performed to investigate whether associations observed in other populations with variants in the DCDC2 and KIAA0319 genes were reproducible in Brazilian dyslexic individuals. Our analysis did not detect any deletions or duplications in the genes studied, and we found no evidence that the allelic variants in the two candidate genes were significantly associated with RD in our sample. Our data do not support a role of the DCDC2/KIAA0319 locus in influencing dyslexia as a categorical trait. Given the genetic complexity of dyslexia, it is plausible that both genes contribute to an increased risk, but the relative influence of these 2 genes on RD varies in different study samples, and/or depends on analytical approaches.

  6. ENU Mutagenesis in Mice Identifies Candidate Genes For Hypogonadism

    Science.gov (United States)

    Weiss, Jeffrey; Hurley, Lisa A.; Harris, Rebecca M.; Finlayson, Courtney; Tong, Minghan; Fisher, Lisa A.; Moran, Jennifer L.; Beier, David R.; Mason, Christopher; Jameson, J. Larry

    2012-01-01

    Genome-wide mutagenesis was performed in mice to identify candidate genes for male infertility, for which the predominant causes remain idiopathic. Mice were mutagenized using N-ethyl-N-nitrosourea (ENU), bred, and screened for phenotypes associated with the male urogenital system. Fifteen heritable lines were isolated and chromosomal loci were assigned using low density genome-wide SNP arrays. Ten of the fifteen lines were pursued further using higher resolution SNP analysis to narrow the candidate gene regions. Exon sequencing of candidate genes identified mutations in mice with cystic kidneys (Bicc1), cryptorchidism (Rxfp2), restricted germ cell deficiency (Plk4), and severe germ cell deficiency (Prdm9). In two other lines with severe hypogonadism candidate sequencing failed to identify mutations, suggesting defects in genes with previously undocumented roles in gonadal function. These genomic intervals were sequenced in their entirety and a candidate mutation was identified in SnrpE in one of the two lines. The line harboring the SnrpE variant retains substantial spermatogenesis despite small testis size, an unusual phenotype. In addition to the reproductive defects, heritable phenotypes were observed in mice with ataxia (Myo5a), tremors (Pmp22), growth retardation (unknown gene), and hydrocephalus (unknown gene). These results demonstrate that the ENU screen is an effective tool for identifying potential causes of male infertility. PMID:22258617

  7. Regional Autonomy and Local Democracy: Independent Candidates Cases

    Directory of Open Access Journals (Sweden)

    Suryanto

    2016-11-01

    Full Text Available One of the efforts to achieve local democracy is through the participation of independent candidates in the Direct General Election in the region. The presence of independent candidates in the Direct General Election gives a great hope to change the political structure of the shackles of the old forces. This paper aims to discuss the implication of regional heads coming from independent candidates on the effectiveness of local governance and the implementation of substantive democracy in the region. The method used is a qualitative approach using descriptive research method. The data collection is done through literature approach. Processing data uses Milles and Huberman interactive models, which includes data reduction, data presentation, and conclusion. The study concluded three things: First, the presence of independent candidates in the Direct General Election gives the opportunities to achieve local democracy that is getting bigger, Second, Regional Heads elected from independent candidates face the challenges of the ineffectiveness of regional government, and Third, within certain limits, the power of elected regional heads from independent lane leads to the realization of democracy that is not substantial.

  8. Integrative analysis to select cancer candidate biomarkers to targeted validation

    Science.gov (United States)

    Heberle, Henry; Domingues, Romênia R.; Granato, Daniela C.; Yokoo, Sami; Canevarolo, Rafael R.; Winck, Flavia V.; Ribeiro, Ana Carolina P.; Brandão, Thaís Bianca; Filgueiras, Paulo R.; Cruz, Karen S. P.; Barbuto, José Alexandre; Poppi, Ronei J.; Minghim, Rosane; Telles, Guilherme P.; Fonseca, Felipe Paiva; Fox, Jay W.; Santos-Silva, Alan R.; Coletta, Ricardo D.; Sherman, Nicholas E.; Paes Leme, Adriana F.

    2015-01-01

    Targeted proteomics has flourished as the method of choice for prospecting for and validating potential candidate biomarkers in many diseases. However, challenges still remain due to the lack of standardized routines that can prioritize a limited number of proteins to be further validated in human samples. To help researchers identify candidate biomarkers that best characterize their samples under study, a well-designed integrative analysis pipeline, comprising MS-based discovery, feature selection methods, clustering techniques, bioinformatic analyses and targeted approaches was performed using discovery-based proteomic data from the secretomes of three classes of human cell lines (carcinoma, melanoma and non-cancerous). Three feature selection algorithms, namely, Beta-binomial, Nearest Shrunken Centroids (NSC), and Support Vector Machine-Recursive Features Elimination (SVM-RFE), indicated a panel of 137 candidate biomarkers for carcinoma and 271 for melanoma, which were differentially abundant between the tumor classes. We further tested the strength of the pipeline in selecting candidate biomarkers by immunoblotting, human tissue microarrays, label-free targeted MS and functional experiments. In conclusion, the proposed integrative analysis was able to pre-qualify and prioritize candidate biomarkers from discovery-based proteomics to targeted MS. PMID:26540631

  9. Comparison of lithium and the eutectic lead lithium alloy, two candidate liquid metal breeder materials for self-cooled blankets

    International Nuclear Information System (INIS)

    Malang, S.; Mattas, R.

    1994-06-01

    Liquid metals are attractive candidates for both near-term and long-term fusion applications. The subjects of this comparison are the differences between the two candidate liquid metal breeder materials Li and LiPb for use in breeding blankets in the areas of neutronics, magnetohydrodynamics, tritium control, compatibility with structural materials, heat extraction system, safety, and required R ampersand D program. Both candidates appear to be promising for use in self-cooled breeding blankets which have inherent simplicity with the liquid metal serving as both breeders and coolant. The remaining feasibility question for both breeder materials is the electrical insulation between liquid metal and duct walls. Different ceramic coatings are required for the two breeders, and their crucial issues, namely self-healing of insulator cracks and radiation induced electrical degradation are not yet demonstrated. Each liquid metal breeder has advantages and concerns associated with it, and further development is needed to resolve these concerns

  10. Teacher candidates' mastery of phoneme-grapheme correspondence: massed versus distributed practice in teacher education.

    Science.gov (United States)

    Sayeski, Kristin L; Earle, Gentry A; Eslinger, R Paige; Whitenton, Jessy N

    2017-04-01

    Matching phonemes (speech sounds) to graphemes (letters and letter combinations) is an important aspect of decoding (translating print to speech) and encoding (translating speech to print). Yet, many teacher candidates do not receive explicit training in phoneme-grapheme correspondence. Difficulty with accurate phoneme production and/or lack of understanding of sound-symbol correspondence can make it challenging for teachers to (a) identify student errors on common assessments and (b) serve as a model for students when teaching beginning reading or providing remedial reading instruction. For students with dyslexia, lack of teacher proficiency in this area is particularly problematic. This study examined differences between two learning conditions (massed and distributed practice) on teacher candidates' development of phoneme-grapheme correspondence knowledge and skills. An experimental, pretest-posttest-delayed test design was employed with teacher candidates (n = 52) to compare a massed practice condition (one, 60-min session) to a distributed practice condition (four, 15-min sessions distributed over 4 weeks) for learning phonemes associated with letters and letter combinations. Participants in the distributed practice condition significantly outperformed participants in the massed practice condition on their ability to correctly produce phonemes associated with different letters and letter combinations. Implications for teacher preparation are discussed.

  11. Transferability of microsatellite markers located in candidate genes for wood properties between Eucalyptus species

    Directory of Open Access Journals (Sweden)

    Cintia V. Acuña

    2014-12-01

    Full Text Available Aim of study:  To analyze the feasibility of extrapolating conclusions on wood quality genetic control between different Eucalyptus species, particularly from species with better genomic information, to those less characterized. For this purpose, the first step is to analyze the conservation and cross-transferability of microsatellites markers (SSRs located in candidate genes.Area of study: Eucalyptus species implanted in Argentina coming from different Australian origins.Materials and methods: Twelve validated and polymorphic SSRs in candidate genes (SSR-CGs for wood quality in E. globulus were selected for cross species amplification in six species: E. grandis, E. saligna, E. dunnii, E. viminalis, E. camaldulensis and E. tereticornis.Main results: High cross-species transferability (92% to 100% was found for the 12 polymorphic SSRs detected in E. globulus. These markers revealed allelic diversity in nine important candidate genes: cinnamoyl CoA reductase (CCR, cellulose synthase 3 (CesA3, the transcription factor LIM1, homocysteine S-methyltransferase (HMT, shikimate kinase (SK, xyloglucan endotransglycosylase 2 (XTH2, glutathione S-transferase (GST, glutamate decarboxylase (GAD and peroxidase (PER.Research highlights: The markers described are potentially suitable for comparative QTL mapping, molecular marker assisted breeding (MAB and for population genetic studies across different species within the subgenus Symphyomyrtus.Keywords: validation; cross-transferability; SSR; functional markers; eucalypts; Symphyomyrtus.

  12. Blood-stage malaria vaccines: post-genome strategies for the identification of novel vaccine candidates.

    Science.gov (United States)

    Ntege, Edward H; Takashima, Eizo; Morita, Masayuki; Nagaoka, Hikaru; Ishino, Tomoko; Tsuboi, Takafumi

    2017-08-01

    An efficacious malaria vaccine is necessary to advance the current control measures towards malaria elimination. To-date, only RTS,S/AS01, a leading pre-erythrocytic stage vaccine completed phase 3 trials, but with an efficacy of 28-36% in children, and 18-26% in infants, that waned over time. Blood-stage malaria vaccines protect against disease, and are considered effective targets for the logical design of next generation vaccines to improve the RTS,S field efficacy. Therefore, novel blood-stage vaccine candidate discovery efforts are critical, albeit with several challenges including, high polymorphisms in vaccine antigens, poor understanding of targets of naturally protective immunity, and difficulties in the expression of high AT-rich plasmodial proteins. Areas covered: PubMed ( www.ncbi.nlm.nih.gov/pubmed ) was searched to review the progress and future prospects of malaria vaccine research and development. We focused on post-genome vaccine candidate discovery, malaria vaccine development, sequence diversity, pre-clinical and clinical trials. Expert commentary: Post-genome high-throughput technologies using wheat germ cell-free protein synthesis technology and immuno-profiling with sera from malaria patients with clearly defined outcomes are highlighted to overcome current challenges of malaria vaccine candidate discovery.

  13. Eight Hundred New Candidates for Globular Clusters in NGC 5128 (Centaurus A)

    Science.gov (United States)

    Harris, Gretchen L. H.; Gómez, Matías; Harris, William E.; Johnston, Kyle; Kazemzadeh, Farnoud; Kerzendorf, Wolfgang; Geisler, Doug; Woodley, Kristin A.

    2012-04-01

    We have used new wide-field imaging with the Magellan IMACS camera to search for globular cluster (GC) candidates around NGC 5128, the nearest giant E galaxy. The imaging data are in the B and R broadband filters and cover a 1.55 deg2 field centered on the galaxy, corresponding to an area about 90 × 90 kpc2 at the distance of NGC 5128. All the fields were taken under exceptionally high-quality seeing conditions (FWHM = 0farcs4-0farcs5 in R). Using this material we are able, for the first time in the literature, to construct a homogeneous list of GC candidates covering a wide span of the NGC 5128 halo and unusually free of field contaminants (foreground stars and faint background galaxies). Selecting the measured objects by color, magnitude, ellipticity, and profile size gives us a final catalog of 833 new high-quality GC candidates brighter than R = 21 (0.8 mag fainter than the standard GC luminosity function turnover point). The measured positions have better than 0farcs2 precision in both coordinates. This list can be used as the basis for spectroscopic follow-up, leading to a more comprehensive kinematic and dynamic study of the halo. This Paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.

  14. Auto-Vetting Transiting Planet Candidates Identified by the Kepler Pipeline

    Science.gov (United States)

    Jenkins, Jon M.; McCauliff, Sean; Burke, Christopher; Seader, Shawn; Twicken, Joseph; Klaus, Todd; Sanderfer, Dwight; Srivastava, Ashok; Haas, Michael R.

    2014-04-01

    The Kepler Mission simultaneously measures the brightness of more than 150,000 stars every 29.4 minutes primarily for the purpose of transit photometry. Over the course of its 3.5-year primary mission Kepler has observed over 190,000 distinct stars, announcing 2,321 planet candidates, 2,165 eclipsing binaries, and 105 confirmed planets. As Kepler moves into its 4-year extended mission, the total number of transit-like features identified in the light curves has increased to as many as ~18,000. This number of signals has become intractable for human beings to inspect by eye in a thorough and timely fashion. To mitigate this problem we are developing machine learning approaches to perform the task of reviewing the diagnostics for each transit signal candidate to establish a preliminary list of planetary candidates ranked from most credible to least credible. Our preliminary results indicate that random forests can classify potential transiting planet signatures with an accuracy of more than 98.6% as measured by the area under a receiver-operating curve.

  15. Major depressive disorder: insight into candidate cerebrospinal fluid protein biomarkers from proteomics studies.

    Science.gov (United States)

    Al Shweiki, Mhd Rami; Oeckl, Patrick; Steinacker, Petra; Hengerer, Bastian; Schönfeldt-Lecuona, Carlos; Otto, Markus

    2017-06-01

    Major Depressive Disorder (MDD) is the leading cause of global disability, and an increasing body of literature suggests different cerebrospinal fluid (CSF) proteins as biomarkers of MDD. The aim of this review is to summarize the suggested CSF biomarkers and to analyze the MDD proteomics studies of CSF and brain tissues for promising biomarker candidates. Areas covered: The review includes the human studies found by a PubMed search using the following terms: 'depression cerebrospinal fluid biomarker', 'major depression biomarker CSF', 'depression CSF biomarker', 'proteomics depression', 'proteomics biomarkers in depression', 'proteomics CSF biomarker in depression', and 'major depressive disorder CSF'. The literature analysis highlights promising biomarker candidates and demonstrates conflicting results on others. It reveals 42 differentially regulated proteins in MDD that were identified in more than one proteomics study. It discusses the diagnostic potential of the biomarker candidates and their association with the suggested pathologies. Expert commentary: One ultimate goal of finding biomarkers for MDD is to improve the diagnostic accuracy to achieve better treatment outcomes; due to the heterogeneous nature of MDD, using bio-signatures could be a good strategy to differentiate MDD from other neuropsychiatric disorders. Notably, further validation studies of the suggested biomarkers are still needed.

  16. Classification study of WISE infrared sources: identification of candidate asymptotic giant branch stars

    Science.gov (United States)

    Tu, Xun; Wang, Zhong-Xiang

    2013-03-01

    In the Wide-field Infrared Survey Explorer (WISE) all-sky source catalog there are 76 million mid-infrared point sources that were detected in the first three WISE bands and have association with only one 2MASS near-IR source within 3″. We search for their identifications in the SIMBAD database and find 3.2 million identified sources. Based on these known sources, we establish three criteria for selecting candidate asymptotic giant branch (AGB) stars in the Galaxy, which are three defined zones in a color-color diagram, Galactic latitude |b| W3c W3c, we estimate their distances and derive their Galactic distributions. The candidates are generally distributed around the Galactic center uniformly, with 68% (1-σ) of them within approximately 8 kpc. We discuss the idea that optical spectroscopy can be used to verify the C-rich AGB stars in our candidates, and thus a fraction of them (~10%) will be good targets for the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) survey that is planned to start in fall of 2012.

  17. Identifying candidate sites for crop biofortification in Latin America: case studies in Colombia, Nicaragua and Bolivia.

    Science.gov (United States)

    Zapata-Caldas, Emmanuel; Hyman, Glenn; Pachón, Helena; Monserrate, Fredy Alexander; Varela, Liliana Vesga

    2009-05-19

    Agricultural science can address a population's vitamin, amino acid and mineral malnutrition through biofortification - agronomy, plant breeding and biotechnology to develop crops with high nutrient contents. Biofortified crop varieties should be grown in areas with populations at risk of nutrient deficiency and in areas where the same crop is already grown and consumed. Information on the population at risk of nutrient deficiency is rarely available for sub-national administrative units, such as provinces, districts, and municipalities. Nor is this type of information commonly analyzed with data on agricultural production. This project developed a method to identify populations at risk of nutrient deficiency in zones with high crop production, places where biofortification interventions could be targeted. Nutrient deficiency risk data were combined with crop production and socioeconomic data to assess the suitability of establishing an intervention. Our analysis developed maps of candidate sites for biofortification interventions for nine countries in Latin America and the Caribbean. Results for Colombia, Nicaragua, and Bolivia are presented in this paper. Interventions in northern Colombia appear promising for all crops, while sites for bean biofortification are widely scattered throughout the country. The most promising sites in Nicaragua are found in the center-north region. Candidate sites for biofortification in Bolivia are found in the central part of the country, in the Andes Mountains. The availability and resolution of data limits the analysis. Some areas show opportunities for biofortification of several crops, taking advantage of their spatial coincidence. Results from this analysis should be confirmed by experts or through field visits. This study demonstrates a method for identifying candidate sites for biofortification interventions. The method evaluates populations at risk of nutrient deficiencies for sub-national administrative regions, and

  18. The joint SKI/SKB scenario development project

    International Nuclear Information System (INIS)

    Andersson, Johan

    1989-12-01

    The Swedish Nuclear Power and Swedish Nuclear Waste Management Co. have carried through a joint scenario development exercise of a hypothetical repository for spent fuel and high level waste based on the KBS-3 concept as disposal method. The starting point has been the 'Sandia methodology', but the actual implementation of the steps in this method has required new strategy development. The work started with a relatively large internationally composed group meeting, which identified an extensive list of features, events and processes (FEPs) that might influence the long term performance of a repository. All these FEPs as well as its possible causes and consequences have been entered into a computer database. The next step in the development was to remove from the list approximately 30 FEPs of low probability or negligible consequence. In a following step a large number of the FEPs on the original list were assigned to the 'PROCESS SYSTEM', comprising the complete set of 'deterministic' chemical and physical processes that might influence the release from the repository to the biosphere. A scenario is defined by a set of external conditions which will influence the processes in the PROCESS SYSTEM. Approximately 50 FEPs were left representing external conditions. The remaining FEPs could all be combined to form scenarios, but it is concluded that it is not meaningful to discuss combinations without first analysing the consequence and probability of the individual conditions. An important aspect of the work is that the developed strategy includes a framework for the documentation of the complete chain of scenario development. Such a transparent documentation makes possible an extensive review and updating of the set of scenarios. A reviewing process, open to very broad groups in the society, is probably the best means of assuring reasonable completeness and of building up a general consensus on what are the critical issues for the safe disposal of radioactive waste

  19. SPLETNI BANČNI PORTALI NA PRIMERU SKB BANKE

    OpenAIRE

    Kristofić, Irena

    2012-01-01

    V dobi informacijske družbe je svetovni splet postal eden izmed najpomembnejših virov podatkov, a se uporabniki med množico strani vedno težje znajde. Pojavil se je trend izgradnje spletnih portalov, ki niso le običajne spletne strani, ampak uporabniku nudijo veliko več. Predstavljajo enotno vstopno točko za uporabnike pri iskanju uporabnih informacij. V grobem delimo spletne portale na splošne uporabniške portale ter na poslovne portale. Splošni uporabniški portali služijo uporabnikom kot vs...

  20. Investigating mathematics teacher candidates opinions about using information & communication technologies

    Directory of Open Access Journals (Sweden)

    Selahattin Arsan

    2011-06-01

    Full Text Available As it has changed all fields in our lives, technological advancements have also improved education in such a large extent that integrating technology into education is inevitable. For this reason, teachers and teacher candidates are supposed to get acquainted with technology related information and skills. This study was conducted to determine the pre-service mathematics teachers’ opinions about information and communication technologies. A questionnaire was applied to 104 mathematics teacher candidates from a university in the Black Sea Region as the data collecting tool. The data was analyzed with statistical software (SPSS 13.0 in terms of average mean, standard deviation and t-tests. Current findings show that mathematics teacher candidates have positive attitude towards applying ICT in classroom settings. Results show no significant difference between the attitudes and owning a computer, using the internet and the department being studied; however there is a significant correlation between attitudes and gender; favoring males.

  1. Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review.

    Science.gov (United States)

    Xiao, Xiao; Wang, Xiaoyu; Gui, Xuan; Chen, Lu; Huang, Baokang

    2016-11-01

    Due to the chemical structural diversity and various analgesic mechanisms, an increasing number of studies indicated that some flavonoids from medicinal plants could be promising candidates for new natural analgesic drugs, which attract high interests of advanced users and academic researchers. The aim of this systematic review is to report flavonoids and its derivatives as new analgesic candidates based on the pharmacological evidences. Sixty-four papers were found concerning the potential analgesic activity of 46 flavonoids. In this case, the evidence for analgesic activity of flavonoids and total flavonoids was investigated. Meanwhile, the corresponding analgesic mechanism of flavonoids was discussed by generalizing and analyzing the current publications. Based on this review, the conclusion can be drawn that some flavonoids are promising candidates for painful conditions and deserve particular attention in further research and development. © 2016 Wiley-VHCA AG, Zurich, Switzerland.

  2. Gravitino, dark matter candidate and implications for big bang nucleosynthesis

    International Nuclear Information System (INIS)

    Bailly, S.

    2008-11-01

    The Standard Model of particle physics was developed in the seventies. Despite many experimental successes, it presents many problems that can only be solved with models beyond the Standard Model. Supersymmetry is an interesting candidate, postulating a new symmetry between fermions and bosons. This model can also have interesting applications in cosmology. It offers potentially good candidates for dark matter, what represents 25% of the energy density of the Universe, and its nature is unknown. Another cosmological problem is the lithium problems in Big Bang Nucleosynthesis describing the production of light elements in the first seconds of the Universe. The lithium abundance predicted by the theory is inconsistent with observations. I study a scenario in which a supersymmetric particle, the gravitino, is the candidate for dark matter and the production of this particle through the decay of other supersymmetric particles may solve the lithium problems. (author)

  3. Candidate container materials for Yucca Mountain waste package designs

    International Nuclear Information System (INIS)

    McCright, R.D.; Halsey, W.G.; Gdowski, G.E.; Clarke, W.L.

    1991-09-01

    Materials considered as candidates for fabricating nuclear waste containers are reviewed in the context of the Conceptual Design phase of a potential repository located at Yucca Mountain. A selection criteria has been written for evaluation of candidate materials for the next phase -- Advanced Conceptual Design. The selection criteria is based on the conceptual design of a thin-walled container fabricated from a single metal or alloy; the criteria consider the performance requirements on the container and the service environment in which the containers will be emplaced. A long list of candidate materials is evaluated against the criteria, and a short list of materials is proposed for advanced characterization in the next design phase

  4. Counts of low-Redshift SDSS quasar candidates

    International Nuclear Information System (INIS)

    Zeljko Ivezic

    2004-01-01

    We analyze the counts of low-redshift quasar candidates selected using nine-epoch SDSS imaging data. The co-added catalogs are more than 1 mag deeper than single-epoch SDSS data, and allow the selection of low-redshift quasar candidates using UV-excess and also variability techniques. The counts of selected candidates are robustly determined down to g = 21.5. This is about 2 magnitudes deeper than the position of a change in the slope of the counts reported by Boyle (and others) (1990, 2000) for a sample selected by UV-excess, and questioned by Hawkins and Veron (1995), who utilized a variability-selected sample. Using SDSS data, we confirm a change in the slope of the counts for both UV-excess and variability selected samples, providing strong support for the Boyle (and others) results

  5. Evaluation and selection of candidate high-level waste forms

    International Nuclear Information System (INIS)

    1982-03-01

    Seven candidate waste forms being developed under the direction of the Department of Energy's National High-Level Waste (HLW) Technology Program, were evaluated as potential media for the immobilization and geologic disposal of high-level nuclear wastes. The evaluation combined preliminary waste form evaluations conducted at DOE defense waste-sites and independent laboratories, peer review assessments, a product performance evaluation, and a processability analysis. Based on the combined results of these four inputs, two of the seven forms, borosilicate glass and a titanate based ceramic, SYNROC, were selected as the reference and alternative forms for continued development and evaluation in the National HLW Program. Both the glass and ceramic forms are viable candidates for use at each of the DOE defense waste-sites; they are also potential candidates for immobilization of commercial reprocessing wastes. This report describes the waste form screening process, and discusses each of the four major inputs considered in the selection of the two forms

  6. Reintroducing resurrected species: selecting DeExtinction candidates.

    Science.gov (United States)

    Seddon, Philip J; Moehrenschlager, Axel; Ewen, John

    2014-03-01

    Technological advances have raised the controversial prospect of resurrecting extinct species. Species DeExtinction should involve more than the production of biological orphans to be scrutinized in the laboratory or zoo. If DeExtinction is to realize its stated goals of deep ecological enrichment, then resurrected animals must be translocated (i.e., released within suitable habitat). Therefore, DeExtinction is a conservation translocation issue and the selection of potential DeExtinction candidates must consider the feasibility and risks associated with reintroduction. The International Union for the Conservation of Nature (IUCN) Guidelines on Reintroductions and Other Conservation Translocations provide a framework for DeExtinction candidate selection. We translate these Guidelines into ten questions to be addressed early on in the selection process to eliminate unsuitable reintroduction candidates. We apply these questions to the thylacine, Yangtze River Dolphin, and Xerces blue butterfly. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. A New Tribological Test for Candidate Brush Seal Materials Evaluation

    Science.gov (United States)

    Fellenstein, James A.; Dellacorte, Christopher

    1994-01-01

    A new tribological test for candidate brush seal materials evaluation has been developed. The sliding contact between the brush seal wires and their mating counterface journal is simulated by testing a small tuft of wire against the outside diameter of a high speed rotating shaft. The test configuration is similar to a standard block on ring geometry. The new tester provides the capability to measure both the friction and wear of candidate wire and counterface materials under controlled loading conditions in the gram to kilogram range. A wide test condition latitude of speeds (1 to 27 m/s), temperatures (25 to 700 C), and loads (0.5 to 10 N) enables the simulation of many of the important tribological parameters found in turbine engine brush seals. This paper describes the new test rig and specimen configuration and presents initial data for candidate seal materials comparing tuft test results and wear surface morphology to field tested seal components.

  8. Fourteen candidate RR Lyrae star streams in the inner Galaxy

    Science.gov (United States)

    Mateu, Cecilia; Read, Justin I.; Kawata, Daisuke

    2018-03-01

    We apply the GC3 stream-finding method to RR Lyrae stars (RRLSs) in the Catalina survey. We find 2 RRLS stream candidates at >4σ confidence and another 12 at >3.5σ confidence over the Galactocentric distance range 4 < D/kpc < 26. Of these, only two are associated with known globular clusters (NGC 1261 and Arp2). The remainder are candidate `orphan' streams, consistent with the idea that globular cluster streams are most visible close to dissolution. Our detections are likely a lower bound on the total number of dissolving globulars in the inner galaxy, since many globulars have few RRLSs, while only the brightest streams are visible over the Galactic RRLS background, particularly given the current lack of kinematical information. We make all of our candidate streams publicly available and provide a new galstreamsPYTHON library for the footprints of all known streams and overdensities in the Milky Way.

  9. Evaluation of candidate geomagnetic field models for IGRF-11

    DEFF Research Database (Denmark)

    Finlay, Chris; Maus, S.; Beggan, C. D.

    2010-01-01

    The eleventh generation of the International Geomagnetic Reference Field (IGRF) was agreed in December 2009 by a task force appointed by the International Association of Geomagnetism and Aeronomy (IAGA) Division V Working Group V-MOD. New spherical harmonic main field models for epochs 2005.0 (DGRF......-2005) and 2010.0 (IGRF-2010), and predictive linear secular variation for the interval 2010.0–2015.0 (SV-2010-2015) were derived from weighted averages of candidate models submitted by teams led by DTU Space, Denmark (team A); NOAA/NGDC, U.S.A. (team B); BGS, U.K. (team C); IZMIRAN, Russia (team D...... include calculations of root mean square vector field differences between the candidates, comparisons of the power spectra, and degree correlations between the candidates and a mean model. Coefficient by coefficient analysis including determination of weighting factors used in a robust estimation of mean...

  10. Certification of biological candidates reference materials by neutron activation analysis

    Science.gov (United States)

    Kabanov, Denis V.; Nesterova, Yulia V.; Merkulov, Viktor G.

    2018-03-01

    The paper gives the results of interlaboratory certification of new biological candidate reference materials by neutron activation analysis recommended by the Institute of Nuclear Chemistry and Technology (Warsaw, Poland). The correctness and accuracy of the applied method was statistically estimated for the determination of trace elements in candidate reference materials. The procedure of irradiation in the reactor thermal fuel assembly without formation of fast neutrons was carried out. It excluded formation of interfering isotopes leading to false results. The concentration of more than 20 elements (e.g., Ba, Br, Ca, Co, Ce, Cr, Cs, Eu, Fe, Hf, La, Lu, Rb, Sb, Sc, Ta, Th, Tb, Yb, U, Zn) in candidate references of tobacco leaves and bottom sediment compared to certified reference materials were determined. It was shown that the average error of the applied method did not exceed 10%.

  11. High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Executive summary: Volume 1

    International Nuclear Information System (INIS)

    Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B.

    1995-06-01

    The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer software used in the safety systems of nuclear power plants. The framework for the work consisted of the following software development and assurance activities: requirements specification; design; coding; verification and validation, including static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire range of software life-cycle activities; the assessment of the technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary, includes an overview of the framework and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; Volume 2 is the main report

  12. High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Main report, Volume 2

    International Nuclear Information System (INIS)

    Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B.

    1995-06-01

    The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer e following software development and assurance activities: Requirements specification; design; coding; verification and validation, inclukding static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire ran e identification, categorization and prioritization of technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary includes an overview of the framwork and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; this document, Volume 2, is the main report

  13. High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Main report, Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B. [Mitre Corp., McLean, VA (United States)

    1995-06-01

    The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer e following software development and assurance activities: Requirements specification; design; coding; verification and validation, inclukding static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire ran e identification, categorization and prioritization of technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary includes an overview of the framwork and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; this document, Volume 2, is the main report.

  14. PEACE: pulsar evaluation algorithm for candidate extraction - a software package for post-analysis processing of pulsar survey candidates

    Science.gov (United States)

    Lee, K. J.; Stovall, K.; Jenet, F. A.; Martinez, J.; Dartez, L. P.; Mata, A.; Lunsford, G.; Cohen, S.; Biwer, C. M.; Rohr, M.; Flanigan, J.; Walker, A.; Banaszak, S.; Allen, B.; Barr, E. D.; Bhat, N. D. R.; Bogdanov, S.; Brazier, A.; Camilo, F.; Champion, D. J.; Chatterjee, S.; Cordes, J.; Crawford, F.; Deneva, J.; Desvignes, G.; Ferdman, R. D.; Freire, P.; Hessels, J. W. T.; Karuppusamy, R.; Kaspi, V. M.; Knispel, B.; Kramer, M.; Lazarus, P.; Lynch, R.; Lyne, A.; McLaughlin, M.; Ransom, S.; Scholz, P.; Siemens, X.; Spitler, L.; Stairs, I.; Tan, M.; van Leeuwen, J.; Zhu, W. W.

    2013-07-01

    Modern radio pulsar surveys produce a large volume of prospective candidates, the majority of which are polluted by human-created radio frequency interference or other forms of noise. Typically, large numbers of candidates need to be visually inspected in order to determine if they are real pulsars. This process can be labour intensive. In this paper, we introduce an algorithm called Pulsar Evaluation Algorithm for Candidate Extraction (PEACE) which improves the efficiency of identifying pulsar signals. The algorithm ranks the candidates based on a score function. Unlike popular machine-learning-based algorithms, no prior training data sets are required. This algorithm has been applied to data from several large-scale radio pulsar surveys. Using the human-based ranking results generated by students in the Arecibo Remote Command Center programme, the statistical performance of PEACE was evaluated. It was found that PEACE ranked 68 per cent of the student-identified pulsars within the top 0.17 per cent of sorted candidates, 95 per cent within the top 0.34 per cent and 100 per cent within the top 3.7 per cent. This clearly demonstrates that PEACE significantly increases the pulsar identification rate by a factor of about 50 to 1000. To date, PEACE has been directly responsible for the discovery of 47 new pulsars, 5 of which are millisecond pulsars that may be useful for pulsar timing based gravitational-wave detection projects.

  15. Welsh Slate: A Candidate for Global Heritage Stone Status

    Science.gov (United States)

    Horak, Jana; Hughes, Terry; Lott, Graham

    2013-04-01

    Slate is the iconic stone of Wales, and has a temporal and geographic record of usage such that it is considered worthy of consideration for Global Heritage Stone status. The reputation of Welsh slate is built on the quality and durability of the stone, enabling it to be used in a wide range of contexts from industrial roofing, through domestic housing to higher prestige buildings. Although metamorphic slates are present in several across Wales, the highest quality roofing material was extracted from just two areas in north-west Wales; the Cambrian Slate Belt, around Bethesda to Nantlle, working purple and green slates of the Llanberis Slate Formation and a second area to the south around Blaenau Ffestiniog - the Ordovician Slate Belt - which works grey slates of the Nant Francon Supergroup. These two areas are considered to form the core of the Welsh Slate Province. Welsh slate has been extracted for at least 2000 years, as evidenced by their presence as roofing slates in Roman forts in North Wales dating from 77AD. Slates from medieval churches and castles in north Wales indicate extraction continued throughout this period. In the 16th century exportation of Welsh slate commenced, initially limited to Ireland and those parts of England where it could be transported by boat. The second half of 18th century saw the first major expansion of the industry, facilitated by improved road transportation and some mechanisation, and subsequently in the 1830s by repeal of punitive boat taxes: production increased substantially through the late 19th century supported by the introduction of steam railways, and both production and exports peaked around 1900. The industry is still active today, although on a much reduced scale, with an estimate of around 20% of output being exported. Considerable reserves of this high quality slate resource remain in North Wales and it is important to ensure that they are protected to maintain continuity of supply to the heritage sector and are

  16. Current understanding of increased insulin sensitivity after exercise - emerging candidates

    DEFF Research Database (Denmark)

    Maarbjerg, Stine Just; Sylow, Lykke; Richter, Erik

    2011-01-01

    signaling component in the insulin signaling pathway such as aPKC, Rac1, TBC1D4 and TBC1D1 have been described. These are all affected by both insulin and exercise which means that they are likely converging points in promoting GLUT4 translocation and therefore possible candidates for regulating insulin...... sensitivity after exercise. Whereas TBC1D1 does not appear to regulate insulin sensitivity after exercise, correlative evidence in contrast suggests TBC1D4 to be a relevant candidate. Little is known about aPKC and Rac1 in relation to insulin sensitivity after exercise. Besides mechanisms involved...

  17. The attitudes of classroom teacher candidates towards physical education lesson

    Directory of Open Access Journals (Sweden)

    Gönül Tekkurşun Demir

    2017-12-01

    Full Text Available Aim: It is aimed to determine the attitudes of the 2nd, 3rd, and 4th grade classroom teacher candidates towards the physical education lesson according to various variables. Material and Methods: For the current study, the screening method, one of the quantitative research models, was used. The research consists of 2nd, 3rd, and 4th grade, totally164 university students, 106 (%64,6 females, 58 (%35,4 males, attending Uşak University, Classroom Teaching Program in 2016-2017 academic year. The first-grade students were not included in this research, because the physical education and play teaching lessons are given to classroom student candidates in the second-grade at Uşak University, Classroom Teaching Program. “Personal information form" and “Physical Education Lesson Attitude Scale for Classroom Teacher Candidates" were used as data collection tools. Before analysis, the data were evaluated using the values of Skewness and Skewness (normal distribution of the data and Levene (equality of variance tests. In the analysis of the data; frequency, arithmetic mean, standard deviation; t-test, ANOVA and Pearson Correlation test were used. Results: When examined the total score of the teacher candidates obtained from Physical Education Lesson Attitude Scale for Classroom Teacher Candidates and age variable by the Pearson Moment Correlation analysis, it was found that there was a statistically significant negative relationship between the received scores at low level. It was determined that the attitudes of the classroom teacher candidates towards the physical education lessons did not show any significant difference according to the gender variable, but there was a significant difference when examined their class levels. While no significant difference was found in the attitudes of the classroom teacher candidates, who played and did not play sports in their past life, towards physical education lessons, no significant difference was found

  18. Dark matter candidates and methods for detecting them

    Science.gov (United States)

    Raffelt, G. G.

    1992-01-01

    A number of experiments employing Ge and Si ionization detectors have excluded large regions in the plane of masses and scattering cross-sections for weakly-interacting dark matter (DM) candidates. It is judged that, before a realistic detection experiment for supersymmetric DM candidates can be conducted, significant development efforts will have to be completed for suitable cryogenic or ionization detectors. Pilot experiments have demonstrated the feasibility of axion searches with microwave cavities, but these are at least two orders of magnitude too low in sensitivity.

  19. Candidal Arthritis After Complete Treatment of Systemic Candidiasis

    Directory of Open Access Journals (Sweden)

    Wen-Bin Hsieh

    2005-04-01

    Full Text Available Over the last few decades, the incidence of invasive candidal infections in neonatal intensive care units has increased dramatically. Various complications, such as arthritis, endocarditis, meningitis, and endophthalmitis, have been reviewed. We present the case of a premature infant with systemic candidemia. Arthritis was discovered 6 months after completion of amphotericin B therapy, and was successfully treated with oral fluconazole for 6 weeks. We conclude that long-term follow-up is particularly important in patients with treated candidemia. To prevent complications, prolonged treatment with high-dose amphotericin B is suggested for systemic fungal infection, and oral fluconazole is an effective alternative for candidal arthritis.

  20. A preliminary systems assessment of the Starlite Demo candidates

    International Nuclear Information System (INIS)

    Bathke, C.G.

    1995-01-01

    The Starlite project has evaluated the following five tokamaks as candidates for the US Demo Power Plant: (1) steady state, first stability regime; (2) pulsed, first stability regime; (3) steady state, second stability regime; (4) steady state, reversed shear; and (5) steady state, low aspect ratio. Systems analysis of these candidates has played an important role in the selection of a reversed-shear tokamak for further conceptual design as a US Demo Power Plant. The cost-based systems analysis that led to the selection of a reversed-shear tokamak is described herein

  1. Environmental Systems Research Candidates Program--FY2000 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Piet, Steven James

    2001-01-01

    The Environmental Systems Research Candidates (ESRC) Program, which is scheduled to end September 2001, was established in April 2000 as part of the Environmental Systems Research and Analysis Program at the Idaho National Engineering and Environmental Laboratory (INEEL) to provide key science and technology to meet the clean-up mission of the U.S. Department of Energy Office of Environmental Management, and perform research and development that will help solve current legacy problems and enhance the INEEL’s scientific and technical capability for solving longer-term challenges. This report documents the progress and accomplishments of the ESRC Program from April through September 2000. The ESRC Program consists of 24 tasks subdivided within four research areas: A. Environmental Characterization Science and Technology. This research explores new data acquisition, processing, and interpretation methods that support cleanup and long-term stewardship decisions. B. Subsurface Understanding. This research expands understanding of the biology, chemistry, physics, hydrology, and geology needed to improve models of contamination problems in the earth’s subsurface. C. Environmental Computational Modeling. This research develops INEEL computing capability for modeling subsurface contaminants and contaminated facilities. D. Environmental Systems Science and Technology. This research explores novel processes to treat waste and decontaminate facilities. Our accomplishments during FY 2000 include the following: • We determined, through analysis of samples taken in and around the INEEL site, that mercury emissions from the INEEL calciner have not raised regional off-INEEL mercury contamination levels above normal background. • We have initially demonstrated the use of x-ray fluorescence to image uranium and heavy metal concentrations in soil samples. • We increased our understanding of the subsurface environment; applying mathematical complexity theory to the problem of

  2. Finding and characterizing candidate targets for the Asteroid Redirect Mission (ARM)

    Science.gov (United States)

    Chodas, P.

    2014-07-01

    NASA's proposed Asteroid Redirect Mission (ARM) leverages key on-going activities in Human Exploration and Space Technology to advance NASA's goals in these areas. One primary objective of ARM would be to develop and demonstrate a high-power Solar Electric Propulsion (SEP) vehicle which would have the capability of moving significant amounts of mass around the solar system. SEP would be a key technology for robust future missions to deep space destinations, possibly including human missions to asteroids or to Mars. ARM would use the SEP vehicle to redirect up to hundreds of tons of material from a near-Earth asteroid into a stable lunar orbit, where a crew flying in an Orion vehicle would rendezvous and dock with it. The crew would perform an extra-vehicular activity (EVA), sample the material, and bring it back to the Earth; follow-on visits would also be possible. Two ARM mission concepts are being studied: one is to go to a small 4-10-meter-diameter asteroid, capture the entire asteroid and guide it into lunar orbit; the other is to go to a large 100-500 meter asteroid, remove a 1-10 meter boulder, and bring the boulder back into lunar orbit. A planetary defense demonstration could be included under either concept. Although some candidate targets are already known for both mission concepts, an observation campaign has been organized to identify more mission candidates. This campaign naturally leverages off of NASA's NEO Observations Program. Enhancements to asteroid search capabilities which will come online soon should increase the discovery rates for ARM candidates and hazardous asteroids alike. For the small-asteroid ARM concept, candidate targets must be smaller than about 12 meters, must follow Earth-like orbits and must naturally approach the Earth closely in the early 2020s, providing the opportunity for a low-velocity capture into the Earth/Moon system. About a dozen candidates are known with absolute magnitudes in the right range and with orbits

  3. Reflections on Museums as Effective Field Sites for Teacher Candidates

    Science.gov (United States)

    Clark, Megan; Ensminger, David; Incandela, Colleen; Moisan, Heidi

    2016-01-01

    A unique partnership among six museums and Loyola University Chicago's "Teaching Learning and Leading with Schools and Communities" teacher preparation program provided cross-disciplinary field sites for understanding and witnessing developmental and learning theories. Pre-service teacher candidates were able to identify constructs and…

  4. Candidate eco-friendly gas mixtures for MPGDs

    Science.gov (United States)

    Benussi, L.; Bianco, S.; Saviano, G.; Muhammad, S.; Piccolo, D.; Ferrini, M.; Parvis, M.; Grassini, S.; Colafranceschi, S.; Kjølbro, J.; Sharma, A.; Yang, D.; Chen, G.; Ban, Y.; Li, Q.

    2018-02-01

    Modern gas detectors for detection of particles require F-based gases for optimal performance. Recent regulations demand the use of environmentally unfriendly F-based gases to be limited or banned. This review studies properties of potential eco-friendly gas candidate replacements.

  5. Conceptual Clarity and Connections: Global Education and Teacher Candidates

    Science.gov (United States)

    Reimer, Kristin; McLean, Lorna R.

    2009-01-01

    In this article, we have explored the experiences of students in a teacher education programme designed to promote the effective teaching of global education. Research to date indicates that, although interest is high among teacher candidates, they often lack confidence in their abilities to bring global education into their future classrooms. By…

  6. The Opinions of the Turkish Teacher Candidates about the Webquest

    Science.gov (United States)

    Akçay, Ahmet

    2017-01-01

    Webquest, first introduced by Dodge in 1995, is a research and inquiry tool that uses the Internet as a resource. The interest of the students regarding the characteristics is included in the related literature according to the researches made. There is a need for studies to be regarded by the teacher candidates for the webquests regarded by the…

  7. Mapping and candidate genes associated with saccharification yield in sorghum.

    Science.gov (United States)

    Wang, Yi-Hong; Acharya, Aniruddha; Burrell, A Millie; Klein, Robert R; Klein, Patricia E; Hasenstein, Karl H

    2013-11-01

    Sorghum (Sorghum bicolor (L.) Moench) is a high-yielding, stress tolerant energy crop for lignocellulosic-based biofuel production. Saccharification is a process by which hydrolytic enzymes break down lignocellulosic materials to fermentable sugars for biofuel production, and mapping and identifying genes underlying saccharification yield is an important first step to genetically improve the plant for higher biofuel productivity. In this study, we used the ICRISAT sorghum mini core germplasm collection and 14 739 single nucleotide polymorphism markers to map saccharification yield. Seven marker loci were associated with saccharification yield and five of these loci were syntenic with regions in the maize genome that contain quantitative trait loci underlying saccharification yield and cell wall component traits. Candidate genes from the seven loci were identified but must be validated, with the most promising candidates being β-tubulin, which determines the orientation of cellulose microfibrils in plant secondary cell walls, and NST1, a master transcription factor controlling secondary cell wall biosynthesis in fibers. Other candidate genes underlying the different saccharification loci included genes that play a role in vascular development and suberin deposition in plants. The identified loci and candidate genes provide information into the factors controlling saccharification yield and may facilitate increasing biofuel production in sorghum.

  8. Candidate New Rotavirus Species in Sheltered Dogs, Hungary

    OpenAIRE

    Mihalov-Kov?cs, Eszter; Gell?rt, ?kos; Marton, Szilvia; Farkas, Szilvia L.; Feh?r, Enik?; Oldal, Mikl?s; Jakab, Ferenc; Martella, Vito; B?nyai, Kriszti?n

    2015-01-01

    We identified unusual rotavirus strains in fecal specimens from sheltered dogs in Hungary by viral metagenomics. The novel rotavirus species displayed limited genome sequence homology to representatives of the 8 rotavirus species, A?H, and qualifies as a candidate new rotavirus species that we tentatively named Rotavirus I.

  9. Genomic dissection and prioritizing of candidate genes of QTL for ...

    Indian Academy of Sciences (India)

    Genomic dissection and prioritizing of candidate genes of QTL for regulating spontaneous arthritis on chromosome 1 in mice deficient for interleukin-1 receptor ... People's Republic of China; Department of Orthopaedic Surgery, Campbell Clinic and Pathology, University of Tennessee Health Science Center, Memphis, TN ...

  10. THE 3 MU-M SPECTRA OF CANDIDATE CARBON STARS

    NARCIS (Netherlands)

    GROENEWEGEN, MAT; DEJONG, T; GEBALLE, TR

    We have searched for the 3.1 mum absorption feature, a well-known characteristic of optical carbon stars, in a sample of sixteen candidate carbon stars, most of which have very red colors and some of which have no optical counterparts. The sample was selected on the basis of similarity of LRS

  11. The training of candidate officers in South Africa | Haines | Scientia ...

    African Journals Online (AJOL)

    Scientia Militaria: South African Journal of Military Studies. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 8, No 3 (1978) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. The training of candidate officers ...

  12. Identification of putative candidate gene markers for grain zinc ...

    African Journals Online (AJOL)

    Nutrients in food crops can be enriched by adopting biofortification. Identifying the target quantitative trait loci (QTL) genes will help achieve biofortification with greater precision and accuracy. The objective of this experiment is to estimate grain zinc content, evaluation of candidate gene markers in recombinant inbred lines ...

  13. Primary School Teacher Candidates' Geometric Habits of Mind

    Science.gov (United States)

    Köse, Nilu¨fer Y.; Tanisli, Dilek

    2014-01-01

    Geometric habits of mind are productive ways of thinking that support learning and using geometric concepts. Identifying primary school teacher candidates' geometric habits of mind is important as they affect the development of their future students' geometric thinking. Therefore, this study attempts to determine primary school teachers' geometric…

  14. Are Teacher and Principal Candidates Prepared to Address Student Cyberbullying?

    Science.gov (United States)

    Styron, Ronald A., Jr.; Bonner, Jessica L.; Styron, Jennifer L.; Bridgeforth, James; Martin, Cecelia

    2016-01-01

    The purpose of this study was to examine the preparation of teacher and principal candidates to address problems created in K-12 settings as a result of cyberbullying. Participants included teacher and principal preparation students. Findings indicated that respondents were familiar with the most common forms of cyberbullying and its impact on…

  15. Teacher Candidates' Attitudes to Using Oral History in History Education

    Science.gov (United States)

    Demircioglu, Ebru

    2016-01-01

    The aim of this research is to determine the views of history teacher candidates towards an oral history project carried out in the Special Teaching Method Course of the history pedagogy program of the Fatih Faculty of Education (FFE) at Karadeniz Technical University in Turkey. An open-ended questionnaire and semi-structured interview were the…

  16. Polymorphisms of candidate genes associated with meat quality and ...

    African Journals Online (AJOL)

    The objectives of this study were to analyse genotype distribution and sequence variations of candidate genes putatively associated with meat quality and disease resistance in exotic and indigenous Vietnamese pig breeds. For this purpose, 340 pigs from four indigenous and two exotic breeds were included in the analysis ...

  17. RARβ gene methylation is a candidate for primary glioblastoma ...

    African Journals Online (AJOL)

    and p15/INK4. These hypermethylated genes have been reported as a marker for prognosis, treatment pro- tocol selection and survival for GBM patients1,7. Abnormal DNA methylation of brain tumors was first discovered 20 years ago and previous methylation stud- ies for candidate genes in brain tissue have concentrated.

  18. The Receptivity of Prospective University Candidates in Lagos ...

    African Journals Online (AJOL)

    This study explored the receptivity of prospective university candidates in Lagos State, Nigeria, to distance learning. The study population comprised 1155 secondary school leavers enrolled in the Joint Admissions and Matriculation Board (JAMB) coaching centres in Lagos Mainland. The study was carried out in two ...

  19. Effects of Critical Thinking Intervention for Early Childhood Teacher Candidates

    Science.gov (United States)

    Han, Heejeong Sophia; Brown, E. Todd

    2013-01-01

    This study is based on an intervention designed to enhance early childhood teacher candidates' critical thinking abilities. The concept, elements, standards, and traits of critical thinking were integrated into the main course contents, and the effects of the intervention were examined. The results indicated that early childhood teacher…

  20. Candidate genes for drought tolerance and improved productivity in ...

    Indian Academy of Sciences (India)

    Madhu

    with an elaborate literature survey for candidate gene products and/or regulatory sequences associated with enhanced drought ... PHT, plant height; PL, panicle length; PVC, polyvinyl chloride; QTL, quantitative trait loci; RCBD, randomized complete block design;. RN, root number ... The CG approach has been utilized suc-.

  1. A Candidate Army Energy and Water Management Strategy

    National Research Council Canada - National Science Library

    Fournier, Donald F; Westervelt, Eileen T

    2004-01-01

    .... This work augments on-going energy and water management initiatives within the Army by developing a new candidate Army level strategy that responds to anticipated legislation; reflects current DOD and DA requirements, vision, and values in light of the current world situation; incorporates sound science and management principles; and organizes and focuses efforts into an integrated program.

  2. HST imaging of MEGA microlensing candidates in M31

    NARCIS (Netherlands)

    Cseresnjes, P; Crotts, APS; de Jong, JTA; Bergier, A; Baltz, EA; Gyuk, G; Kuijken, K; Widrow, LM

    2005-01-01

    We investigate HST/ACS and WFPC2 images at the positions of five candidate microlensing events from a large survey of variability in M31 (MEGA). Three closely match unresolved sources, and two produce only flux upper limits. All are confined to regions of the color-magnitude diagram where stellar

  3. Generating Genome-Scale Candidate Gene Lists for Pharmacogenomics

    DEFF Research Database (Denmark)

    Hansen, Niclas Tue; Brunak, Søren; Altman, R. B.

    2009-01-01

    A critical task in pharmacogenomics is identifying genes that may be important modulators of drug response. High-throughput experimental methods are often plagued by false positives and do not take advantage of existing knowledge. Candidate gene lists can usefully summarize existing knowledge...

  4. Candidate genes for drought tolerance and improved productivity in ...

    Indian Academy of Sciences (India)

    Madhu

    tropics. Improving drought tolerance and productivity is one of the most difficult tasks for cereal breeders. The diffi- culty arises from the diverse strategies adopted by plants themselves to combat drought stress depending on the timing,. Candidate genes for drought tolerance and improved productivity in rice (Oryza sativa L.).

  5. The Hidden Curriculum: Candidate Diversity in Educational Leadership Preparation

    Science.gov (United States)

    Karanxha, Zorka; Agosto, Vonzell; Bellara, Aarti P.

    2014-01-01

    The authors describe a process of self-assessment attuned to equity and justice in the policies and practices that affect student diversity, namely, those associated with the selection of candidates. The disproportionate rate of rejection for applicants from underrepresented groups and the unsystematic process of applicant selection operated as…

  6. Designing a test of neutrinos as dark matter candidates

    CERN Multimedia

    Marquit, Mirandu

    2008-01-01

    One of the biggest mysteries of the universe deals with questions of dark matter. There are several experiments and models being designed all over the world to try and determine what would make good dark matter candidates. And with the Large Hadron Collider (LHC) at CERN in Switzerland, some of these experiments may be ready for testing.

  7. Art, Music, and Movement Connections for Elementary Education Teacher Candidates

    Science.gov (United States)

    Bohannon, R. Larry; McDowell, Carol

    2010-01-01

    Visual arts, movement, and music are all connected by common structural elements. The lesson described in this article was prepared so that teacher candidates in elementary education may make connections among music, movement, and the visual arts using an elemental integration approach. This lesson used visual art to introduce the concept of line…

  8. Characteristics of hepatitis C in renal transplant candidates.

    Science.gov (United States)

    Cotler, Scott J; Diaz, Gloria; Gundlapalli, Sushama; Jakate, Shiram; Chawla, Anshuman; Mital, Deepak; Jensik, Steven; Jensen, Donald M

    2002-08-01

    To characterize hepatitis C in renal transplant candidates and to compare hepatitis C-related liver disease between patients with end-stage renal disease (ESRD) and well-matched control subjects without renal disease. Hepatitis C is common in dialysis patients and can cause morbidity and mortality in renal transplant recipients. Patients with advanced hepatitis C often are excluded from renal transplantation. Forty-six renal transplant candidates and 46 control subjects matched for age, sex, and race without renal disease were included. Demographic, laboratory, and histologic data were compared between patients with ESRD and control subjects. Alanine aminotransferase levels were significantly lower in patients with ESRD (p < 0.001). Hepatitis C virus RNA levels were similar between groups. Patients with ESRD had less inflammatory activity (p < 0.001) and a lower proportion of bridging fibrosis or cirrhosis (13%) than control subjects (30%, p = 0.043). Clinical and laboratory features did not predict histologic grade or stage of hepatitis C in patients with ESRD. Two complications of percutaneous liver biopsy occurred per three diagnoses of cirrhosis in patients with ESRD. No complications occurred with transjugular liver biopsy in this group. Patients with ESRD had less severe hepatitis C than did control subjects. Clinical measurements did not predict histologic findings in renal transplant candidates. Transjugular liver biopsy should be considered to stage hepatitis C in renal transplant candidates due to the risk of percutaneous biopsy in uremic patients.

  9. Genomic dissection and prioritizing of candidate genes of QTL

    Indian Academy of Sciences (India)

    Genomic dissection and prioritizing of candidate genes of QTL for regulating spontaneous arthritis on chromosome 1 in mice deficient for interleukin-1 receptor antagonist. Yanhong Cao Jifei Zhang Yan Jiao Jian Yan Feng Jiao Xiaoyun Liu Robert W. Williams Karen A. Hasty John M. Stuart Weikuan Gu. Research Article ...

  10. Genomic dissection and prioritizing of candidate genes of QTL for ...

    Indian Academy of Sciences (India)

    Genomic dissection and prioritizing of candidate genes of QTL for regulating spontaneous arthritis on chromosome 1 in mice deficient for interleukin-1 receptor antagonist. Yanhong Cao, Jifei Zhang, Yan Jiao, Jian Yan, Feng Jiao, XiaoYun Liu, Robert W. Williams, Karen A. Hasty,. John M. Stuart and Weikuan Gu. J. Genet.

  11. IT Service Management A guide for ITIL Foundation Exam candidates

    CERN Document Server

    Brewster, Ernest; Lawes, Aidan; Sansbury, John

    2012-01-01

    ITIL® is a framework for IT service management and provides best management practice to meet ISO/IEC 20k. This guide introduces ITIL to Foundation Exam candidates and offers a practical understanding of IT service management. The new edition is fully updated and contains several additional processes. An ITIL® licensed product.

  12. Teacher Candidates' Opinions on Erasmus Student Exchange Program

    Science.gov (United States)

    Unlu, Ihsan

    2015-01-01

    This study contains teacher candidates' opinions who spent a portion of their educational career abroad as participants in the Erasmus Program regarding the academic, cultural, and personal gains of the program. Using the Quantitative Research Method, this study focuses on phenomena that researchers are aware of, but on which they do not have…

  13. Investigation the Technology Usage Level of Teacher Candidates

    Science.gov (United States)

    Korucu, Agah Tugrul; Yucel, Ahmet; Gundogdu, Mustafa M.; Gencturk, Tarik A.

    2016-01-01

    Necessity to train individuals who are away from the digital divide that is defined as the gap between the masses who can make use of information technology effectively and who do not have access to information technology due to lack of education (Uckan, 2009). The aim of this study is to analyse the digital competence of teacher candidates in…

  14. 'Omics' approaches in tomato aimed at identifying candidate genes ...

    African Journals Online (AJOL)

    adriana

    2013-12-04

    Dec 4, 2013 ... that provides a virtual workbench for researchers working ... lab, we undertook two different 'omics' approaches to in- .... In our laboratory, an association mapping approach by candidate gene has been undertaken with the aim of identifying among 96 different genotypes new alleles in genes that could.

  15. Views of the Social Teacher Candidates about Light Pollution

    Science.gov (United States)

    Polat, Suat; Bekdemir, Ünsal

    2017-01-01

    The purpose of this study is to determine the views of social studies of teacher candidates about light pollution. This research is designed by using qualitative research method. In the research, case studies--that is one of the qualitative research methods--is used. Case study is a kind of research that offers a rich perspective on analyzing the…

  16. Optical observations of planetary nebula candidates from the northern hemisphere

    NARCIS (Netherlands)

    VandeSteene, GC; Jacoby, GH; Pottasch, [No Value

    We present H alpha+[N II] images of 17 and low resolution spectra of 14 IRAS-selected planetary nebula candidates. The H alpha+[N II] images are presented as finding charts. Contour plots are shown for the resolved planetary nebulae. From these images accurate optical positions and mean optical

  17. Documenting Teacher Candidates' Professional Growth through Performance Evaluation

    Science.gov (United States)

    Brown, Elizabeth Levine; Suh, Jennifer; Parsons, Seth A.; Parker, Audra K.; Ramirez, Erin M.

    2015-01-01

    In the United States, colleges of education are responding to demands for increased accountability. The purpose of this article is to describe one teacher education program's implementation of a performance evaluation tool during final internship that measures teacher candidates' development across four domains: Planning and Preparation,…

  18. Harnessing gene expression networks to prioritize candidate epileptic encephalopathy genes.

    Science.gov (United States)

    Oliver, Karen L; Lukic, Vesna; Thorne, Natalie P; Berkovic, Samuel F; Scheffer, Ingrid E; Bahlo, Melanie

    2014-01-01

    We apply a novel gene expression network analysis to a cohort of 182 recently reported candidate Epileptic Encephalopathy genes to identify those most likely to be true Epileptic Encephalopathy genes. These candidate genes were identified as having single variants of likely pathogenic significance discovered in a large-scale massively parallel sequencing study. Candidate Epileptic Encephalopathy genes were prioritized according to their co-expression with 29 known Epileptic Encephalopathy genes. We utilized developing brain and adult brain gene expression data from the Allen Human Brain Atlas (AHBA) and compared this to data from Celsius: a large, heterogeneous gene expression data warehouse. We show replicable prioritization results using these three independent gene expression resources, two of which are brain-specific, with small sample size, and the third derived from a heterogeneous collection of tissues with large sample size. Of the nineteen genes that we predicted with the highest likelihood to be true Epileptic Encephalopathy genes, two (GNAO1 and GRIN2B) have recently been independently reported and confirmed. We compare our results to those produced by an established in silico prioritization approach called Endeavour, and finally present gene expression networks for the known and candidate Epileptic Encephalopathy genes. This highlights sub-networks of gene expression, particularly in the network derived from the adult AHBA gene expression dataset. These networks give clues to the likely biological interactions between Epileptic Encephalopathy genes, potentially highlighting underlying mechanisms and avenues for therapeutic targets.

  19. Teacher Candidates' Attitudes towards the Teaching Profession in Turkey

    Science.gov (United States)

    Tok, Turkay Nuri

    2012-01-01

    This study examined the attitudes of teacher candidates in Turkey towards the teaching profession. Descriptive surveys were used and the research data was obtained from Pamukkale University Classroom Teaching students. During data analysis, the arithmetic means and standard deviations of the groups were calculated and a t-test and One-Way ANOVA…

  20. Isolation and characterization of a candidate gene for resistance to ...

    African Journals Online (AJOL)

    xudelin

    2012-05-17

    May 17, 2012 ... Cereal cyst nematode (CCN) (Heterodera avenae Woll.) is one of the most economically damaging endoparasite pests of wheat worldwide. We isolated and characterized a novel cereal CCN resistance candidate gene, CreV8, from Aegilops variabilis (2n = 28, UUSvSv). The gene was 3,568 bp long and.

  1. Planet Candidate Validation in K2 Crowded Fields

    Science.gov (United States)

    Rampalli, Rayna; Vanderburg, Andrew; Latham, David; Quinn, Samuel

    2018-01-01

    In just three years, the K2 mission has yielded some remarkable outcomes with the discovery of over 100 confirmed planets and 500 reported planet candidates to be validated. One challenge with this mission is the search for planets located in star-crowded regions. Campaign 13 is one such example, located towards the galactic plane in the constellation of Taurus. We subject the potential planetary candidates to a validation process involving spectroscopy to derive certain stellar parameters. Seeing-limited on/off imaging follow-up is also utilized in order to rule out false positives due to nearby eclipsing binaries. Using Markov chain Monte Carlo analysis, the best-fit parameters for each candidate are generated. These will be suitable for finding a candidate’s false positive probability through methods including feeding such parameters into the Validation of Exoplanet Signals using a Probabilistic Algorithm (VESPA). These techniques and results serve as important tools for conducting candidate validation and follow-up observations for space-based missions such as the upcoming TESS mission since TESS’s large camera pixels resemble K2’s star-crowded fields.

  2. Identification of genes from the Treacher Collins candidate region

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, M.; Dixon, J.; Edwards, S. [Univ. of California, Irvine, CA (United States)]|[Univ. of Manchester (United Kingdom)] [and others

    1994-09-01

    Treacher Collins syndrome (TCOF1) is an autosomal dominant disorder of craniofacial development. The TCOF1 locus has previously been mapped to chromosome 5q32-33. The candidate gene region has been defined as being between two flanking markers, ribosomal protein S14 (RPS14) and Annexin 6 (ANX6), by analyzing recombination events in affected individuals. It is estimated that the distance between these flanking markers is 500 kb by three separate analysis methods: (1) radiation hybrid mapping; (2) genetic linkage; and (3) YAC contig analysis. A cosmid contig which spans the candidate gene region for TCOF1 has been constructed by screening the Los Alamos National Laboratory flow-sorted chromosome 5 cosmid library. Cosmids were obtained by using a combination of probes generated from YAC end clones, Alu-PCR fragments from YACs, and asymmetric PCR fragments from both T7 and T3 cosmid ends. Exon amplifications, the selection of genomic coding sequences based upon the presence of functional splice acceptor and donor sites, was used to identify potential exon sequences. Sequences found to be conserved between species were then used to screen cDNA libraries in order to identify candidate genes. To date, four different cDNAs have been isolated from this region and are being analyzed as potential candidate genes for TCOF1. These include the genes encoding plasma glutathione peroxidase (GPX3), heparin sulfate sulfotransferase (HSST), a gene with homology to the ETS family of proteins and one which shows no homology to any known genes. Work is also in progress to identify and characterize additional cDNAs from the candidate gene region.

  3. A Refined Catalogue of Phoenix Dwarf Galaxy Giant Star Candidates

    Science.gov (United States)

    Tobolewski, Joshua; Siegel, M.; Palma, C.; Charlton, J.

    2005-12-01

    Continuing our studies of the Phoenix dwarf irregular galaxy and its extended tidal structure, we present the results of a survey using improved photometry with the Washington M-T2-DDO51 photometric method. The three-filter method has the ability to discriminate low surface-gravity giant stars from high surface gravity dwarfs and has proven successful at showing extended distributions of giant stars in other dSph satellites of the Milky Way. Our survey of Phoenix, the most distant (Rgc > 400kpc) of the Milky Way's bound satellites, was taken over a 0.5 square degree region obtained with the CTIO 4-meter telescope and Mosaic II camera. Relying on conservative cuts in photometric error and stellar shape parameter space, our photometry provides a clean list of extratidal giant star candidates. We find 250 giant candidates in our survey that pass both color-magnitude and color-color constraint cuts. Of these, we have roughly 29 candidate giant stars that lie outside the tidal radius of Phoenix. This number of candidate extratidal stars has not been adjusted for background contamination. Further investigations are required to determine if any of these stars were once bound to Phoenix. Using the entire sample of candidate giant stars associated with Phoenix, we also see structural differences in the spatial distribution of high and low metallicity giant stars within the galaxy. Similar differences in the spatial distribution of young and old stars in Phoenix have been noted by other authors. Finally, we compare our photometric selection of Phoenix stars with spectroscopically verified giant stars from Gallart et al (2001) and find that our selection process is successful in identifying these stars as giants, suggesting a high efficiency in selecting giants. We gratefully acknowledge funding for this work from an NSF REU supplement and grant AST 0306884.

  4. Discovery of Diffuse Dwarf Galaxy Candidates around M101

    Science.gov (United States)

    Bennet, P.; Sand, D. J.; Crnojević, D.; Spekkens, K.; Zaritsky, D.; Karunakaran, A.

    2017-11-01

    We have conducted a search of a 9 deg2 region of the Canada-France-Hawaii-Telescope Legacy Survey around the Milky Way analog M101 (D ˜ 7 Mpc), in order to look for previously unknown low-surface-brightness galaxies. This search has uncovered 38 new low-surface-brightness dwarf candidates, and confirmed 11 previously reported galaxies, all with central surface brightness μ(g, 0) > 23 mag arcsec-2, potentially extending the satellite luminosity function for the M101 group by ˜1.2 mag. The search was conducted using an algorithm that nearly automates the detection of diffuse dwarf galaxies. The candidates’ small sizes and low surface brightnesses mean that the faintest of these objects would likely be missed by traditional visual or computer detection techniques. The dwarf galaxy candidates span a range of -7.1 ≥ M g ≥ -10.2 and half-light radii of 118-540 pc at the distance of M101, and they are well fit by simple Sérsic surface brightness profiles. These properties are consistent with dwarfs in the Local Group, and to match the Local Group luminosity function, ˜10-20 of these candidates should be satellites of M101. Association with a massive host is supported by the lack of detected star formation and the overdensity of candidates around M101 compared to the field. The spatial distribution of the dwarf candidates is highly asymmetric, and concentrated to the northeast of M101, therefore distance measurements will be required to determine if these are genuine members of the M101 group.

  5. Quiet areas

    DEFF Research Database (Denmark)

    Petersen, Rikke Munck

    2016-01-01

    perception as a result of its interrelationships between motion, gaze, and sound. This paper uses four films, one of which is a drone flyover, to launch a discussion concerning a smooth and alluring gaze, a sliding gaze that penetrates landscapes, and site appearance. Films hold the capacity to project both...... a site and near-sensory experience. In so doing, films can achieve an intimate reflection of both outer experience and affection of inner sensations, and the audio-visual and time-space based presentation of this dualism can mimic human experience. This paper discusses how this embedded transference...... and transcendence can facilitate a deeper understanding of intimate sensations, substantiating their role in the future design and planning of urban landscapes. Hence, it addresses the ethics of an intimacy perspective (of drone filming) in the qualification of quiet areas....

  6. A Research on the Burnout and the Teaching Profession Attitudes of Teacher Candidates

    Science.gov (United States)

    Kadi, Aysegül; Beytekin, Osman Ferda; Arslan, Hasan

    2015-01-01

    Purpose of this study is to examine burnout and teaching profession attitudes of teacher candidates. Research was conducted with 287 teacher candidates. By the findings; burnout and teaching profession attitudes of teacher candidates don't differ according to their gender. Burnout of teacher candidates differs according to their graduation status…

  7. Framing the Socialisation Process of the DBA Candidate: What Can Universities Offer and What Should Candidates Bring?

    Science.gov (United States)

    Pervan, Simon; Blackman, Deborah; Sloan, Terry; Wallace, Michelle; Vocino, Andrea; Byrne, Cathy

    2016-01-01

    In Australia, the Doctorate of Business Administration (DBA) remains a popular program but considerable anguish persists within the university sector over just what it is offering students. In this article, we use the process of postgraduate socialisation to understand how candidates, supervisors and administrators navigate pathways to successful…

  8. Examination of the Attitudes of Preschool Teacher Candidates and Teacher Candidates in Other Branches towards Scientific Research in Terms of Some Variables

    Science.gov (United States)

    Ekici, Fatma Yasar

    2017-01-01

    The main objective of this study is to examine the attitudes of preschool teacher candidates and teacher candidates in other branches towards scientific research in terms of some variables. Survey method was used. The study group consists of 547 teacher candidates studying in education faculty of a private university in the spring term of…

  9. Molecular Gas toward the Gemini OB1 Molecular Cloud Complex. II. CO Outflow Candidates with Possible WISE Associations

    Science.gov (United States)

    Li, Yingjie; Li, Fa-Cheng; Xu, Ye; Wang, Chen; Du, Xin-Yu; Yang, Wenjin; Yang, Ji

    2018-03-01

    We present a large-scale survey of CO outflows in the Gem OB1 molecular cloud complex and its surroundings, using the Purple Mountain Observatory Delingha 13.7 m telescope. A total of 198 outflow candidates were identified over a large area (∼58.5 square degrees), of which 193 are newly detected. Approximately 68% (134/198) are associated with the Gem OB1 molecular cloud complex, including clouds GGMC 1, GGMC 2, BFS 52, GGMC 3, and GGMC 4. Other regions studied are: the Local arm (Local Lynds, West Front), Swallow, Horn, and Remote cloud. Outflow candidates in GGMC 1, BFS 52, and Swallow are mainly located at ring-like or filamentary structures. To avoid excessive uncertainty in distant regions (≳3.8 kpc), we only estimated the physical parameters for clouds in the Gem OB1 molecular cloud complex and in the Local arm. In those clouds, the total kinetic energy and the energy injection rate of the identified outflow candidates are ≲1% and ≲3% of the turbulent energy and the turbulent dissipation rate of each cloud, indicating that the identified outflow candidates cannot provide enough energy to balance turbulence of their host cloud at the scale of the entire cloud (several to dozens of parsecs). The gravitational binding energy of each cloud is ≳135 times the total kinetic energy of the identified outflow candidates within the corresponding cloud, indicating that the identified outflow candidates cannot cause major disruptions to the integrity of their host cloud at the scale of the entire cloud.

  10. The Planck Catalogue of High-z source candidates

    Science.gov (United States)

    Montier, Ludovic

    2015-08-01

    The Planck satellite has provided the first FIR/submm all-sky survey with a sensitivity allowing us to identify the rarest, most luminous high-z dusty star-forming sources on the sky. It opens a new window on these extreme star-forming systems at redshift above 1.5, providing a powerful laboratory to study the mechanisms of galaxy evolution and enrichment in the frame of the large scale structure growth.I will describe how the Planck catalogue of high-z source candidates (PHz, Planck 2015 in prep.) has been built and charcaterized over 25% of the sky by selecting the brightest red submm sources at a 5' resolution. Follow-up observations with Herschel/SPIRE over 228 Planck candidates have shown that 93% of these candidates are actually overdensities of red sources with SEDs peaking at 350um (Planck Int. results. XXVII 2014). Complementarily to this population of objects, 12 Planck high-z candidates have been identified as strongly lensed star forming galaxies at redshift lying between 2.2 and 3.6 (Canameras et al 2015 subm.), with flux densities larger than 400 mJy up to 1 Jy at 350um, and strong magnification factors. These Planck lensed star-forming galaxies are the rarest brightest lensed in the submm range, providing a unique opportunity to extend the exploration of the star-forming system in this range of mass and redshift.I will detail further a specific analysis performed on a proto-cluster candidate, PHz G95.5-61.6, identified as a double structure at z=1.7 and z=2.03, using an extensive follow-up program (Flores-Cacho et al 2015 subm.). This is the first Planck proto-cluster candidate with spectroscopic confirmation, which opens a new field of statistical analysis about the evolution of dusty star-forming galaxies in such accreting structures.I will finally discuss how the PHz catalogue may help to answer some of the fundamental questions like: At what cosmic epoch did massive galaxy clusters form most of their stars? Is star formation more or less vigorous

  11. Data requirements and data sources for biodiversity priority area ...

    Indian Academy of Sciences (India)

    Prioritizing areas means comparing candidate areas, so the data used to make such comparisons should be comparable in quality and quantity. Potential sources of suitable data include museums, herbariums and natural resource management agencies. Issues of data precision, accuracy and sampling bias in data sets ...

  12. Mucus can change the permeation rank order of drug candidates

    DEFF Research Database (Denmark)

    Hagesaether, Ellen; Christiansen, Elisabeth; Due-Hansen, Maria Elisabeth

    2013-01-01

    The aim of the study was to test the effect of mucus on the permeability of newly developed structurally related free fatty acid receptor 1-agonists TUG-488, TUG-499 and TUG-424, which were compared to the more hydrophilic ketoprofen and the more hydrophobic testosterone as reference drugs...... a minor influence. However, for one of the drug candidates, TUG-499, mucus had a clear impact, and this could not be explicitly related to the hydrophobicity of this compound. Secreted mucus thus changed the obtained rank order of permeation. This was especially apparent when the experiments were carried...... out at a lower agitation. These results indicate that an experimental system without mucus can give a faulty rank order of permeation compared to mucous membranes when structurally related drug candidates are tested....

  13. Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes

    DEFF Research Database (Denmark)

    Russell, Meaghan K; Longoni, Mauro; Wells, Julie

    2012-01-01

    expression profiling of developing embryonic diaphragms would help identify genes likely to be associated with diaphragm defects. We generated a time series of whole-transcriptome expression profiles from laser captured embryonic mouse diaphragms at embryonic day (E)11.5 and E12.5 when experimental...... perturbations lead to CDH phenotypes, and E16.5 when the diaphragm is fully formed. Gene sets defining biologically relevant pathways and temporal expression trends were identified by using a series of bioinformatic algorithms. These developmental sets were then compared with a manually curated list of genes...... previously shown to cause diaphragm defects in humans and in mouse models. Our integrative filtering strategy identified 27 candidates for CDH. We examined the diaphragms of knockout mice for one of the candidate genes, pre-B-cell leukemia transcription factor 1 (Pbx1), and identified a range of previously...

  14. Cryogenic thermal conductivity measurements on candidate materials for space missions

    Science.gov (United States)

    Tuttle, James; Canavan, Edgar; Jahromi, Amir

    2017-12-01

    Spacecraft and instruments on space missions are built using a wide variety of carefully-chosen materials. It is common for NASA engineers to propose new candidate materials which have not been totally characterized at cryogenic temperatures. In many cases a material's cryogenic thermal conductivity must be known before selecting it for a specific space-flight application. We developed a test facility in 2004 at NASA's Goddard Space Flight Center to measure the longitudinal thermal conductivity of materials at temperatures between 4 and 300 K, and we have characterized many candidate materials since then. The measurement technique is not extremely complex, but proper care to details of the setup, data acquisition and data reduction is necessary for high precision and accuracy. We describe the thermal conductivity measurement process and present results for ten engineered materials, including alloys, polymers, composites, and a ceramic.

  15. Vaccine Candidates against Nontypeable Haemophilus influenzae: a Review

    Science.gov (United States)

    Behrouzi, Ava; Vaziri, Farzam; Rahimi-Jamnani, Fatemeh; Afrough, Parviz; Rahbar, Mohammad; Satarian, Fereshteh; Siadat, Seyed Davar

    2017-01-01

    Nonencapsulated, nontypeable Hemophilus influenzae (NTHi) remains an important cause of acute otitis and respiratory diseases in children and adults. NTHi bacteria are one of the major causes of respiratory tract infections, including acute otitis media, cystic fibrosis, and community-acquired pneumonia among children, especially in developing countries. The bacteria can also cause chronic diseases such as chronic bronchitis and chronic obstructive pulmonary disease in the lower respiratory tract of adults. Such bacteria express several outer membrane proteins, some of which have been studied as candidates for vaccine development. Due to the lack of effective vaccines as well as the spread and prevalence of NTHi worldwide, there is an urgent need to design and develop effective vaccine candidates against these strains. PMID:28088130

  16. Tests of candidate materials for particle bed reactors

    International Nuclear Information System (INIS)

    Horn, F.L.; Powell, J.R.; Wales, D.

    1987-01-01

    Rhenium metal hot frits and zirconium carbide-coated fuel particles appear suitable for use in flowing hydrogen to at least 2000 K, based on previous tests. Recent tests on alternate candidate cooled particle and frit materials are described. Silicon carbide-coated particles began to react with rhenium frit material at 1600 K, forming a molten silicide at 2000 K. Silicon carbide was extensively attacked by hydrogen at 2066 K for 30 minutes, losing 3.25% of its weight. Vitrous carbon was also rapidly attacked by hydrogen at 2123 K, losing 10% of its weight in two minutes. Long term material tests on candidate materials for closed cycle helium cooled particle bed fuel elements are also described. Surface imperfections were found on the surface of pyrocarbon-coated fuel particles after ninety days exposure to flowing (∼500 ppM) impure helium at 1143 K. The imperfections were superficial and did not affect particle strength

  17. Abrasion of Candidate Spacesuit Fabrics by Simulated Lunar Dust

    Science.gov (United States)

    Gaier, James R.; Meador, Mary Ann; Rogers, Kerry J.; Sheehy, Brennan H.

    2009-01-01

    A protocol has been developed that produced the type of lunar soil abrasion damage observed on Apollo spacesuits. This protocol was then applied to four materials (Kevlar (DuPont), Vectran (Kuraray Co., Ltd.), Orthofabric, and Tyvek (DuPont)) that are candidates for advanced spacesuits. Three of the four new candidate fabrics (all but Vectran) were effective at keeping the dust from penetrating to layers beneath. In the cases of Kevlar and Orthofabric this was accomplished by the addition of a silicone layer. In the case of Tyvek, the paper structure was dense enough to block dust transport. The least abrasive damage was suffered by the Tyvek. This was thought to be due in large part to its non-woven paper structure. The woven structures were all abraded where the top of the weave was struck by the abrasive. Of these, the Orthofabric suffered the least wear, with both Vectran and Kevlar suffering considerably more extensive filament breakage.

  18. Utility of proverb interpretation measures with cardiac transplant candidates.

    Science.gov (United States)

    Dugbartey, A T

    1998-12-01

    To assess metaphorical understanding and proverb interpretation in cardiac transplant candidates, the neuropsychological assessment records of 22 adults with end-stage cardiac disease under consideration for transplantation were analyzed. Neuropsychological tests consisted of the Controlled Oral Word Association Test, Halstead Category Test, Rey-Osterrieth Complex Figure Test (Copy), Trial Making Test, and summed scores for the proverb items of the WAIS-R Comprehension subtest. Analysis showed that the group tended to interpret proverbs literally. Proverb scores were significantly associated with scores on the Similarities and Picture Arrangement subtests of the WAIS-R. There was a moderate negative association between number of reported heart attacks and Proverb scores. The need for brief yet robust assessments including measures of inferential thinking and conceptualization in transplant candidates are highlighted.

  19. A novel live-attenuated vaccine candidate for mayaro Fever.

    Directory of Open Access Journals (Sweden)

    William J Weise

    2014-08-01

    Full Text Available Mayaro virus (MAYV is an emerging, mosquito-borne alphavirus that causes a dengue-like illness in many regions of South America, and which has the potential to urbanize. Because no specific treatment or vaccine is available for MAYV infection, we capitalized on an IRES-based approach to develop a live-attenuated MAYV vaccine candidate. Testing in infant, immunocompetent as well as interferon receptor-deficient mice demonstrated a high degree of attenuation, strong induction of neutralizing antibodies, and efficacy against lethal challenge. This vaccine strain was also unable to infect mosquito cells, a major safety feature for a live vaccine derived from a mosquito-borne virus. Further preclinical development of this vaccine candidate is warranted to protect against this important emerging disease.

  20. Ebola Virus Disease Candidate Vaccines Under Evaluation in Clinical Trials

    Science.gov (United States)

    Martins, Karen A.; Jahrling, Peter B.; Bavari, Sina; Kuhn, Jens H.

    2016-01-01

    Summary Filoviruses are the etiological agents of two human illnesses: Ebola virus disease and Marburg virus disease. Until 2013, medical countermeasure development against these afflictions was limited to only a few research institutes worldwide as both infections were considered exotic due to very low case numbers. Together with the high case-fatality rate of both diseases, evaluation of any candidate countermeasure in properly controlled clinical trials seemed impossible. However, in 2013, Ebola virus was identified as the etiological agent of a large disease outbreak in Western Africa including almost 30,000 infections and more than 11,000 deaths, including case exportations to Europe and North America. These large case numbers resulted in medical countermeasure development against Ebola virus disease becoming a global public-health priority. This review summarizes the status quo of candidate vaccines against Ebola virus disease, with a focus on those that are currently under evaluation in clinical trials. PMID:27160784

  1. Neuropsychological assessment in kidney and liver transplantation candidates.

    Science.gov (United States)

    Lacerda, S S; Guimaro, M S; Prade, C V; Ferraz-Neto, B H; Karam, C H; Andreoli, P B A

    2008-04-01

    Chronic renal and liver diseases are associated with cognitive and intellectual impairment, which can be irreversible even after kidney or liver transplantation. We sought to investigate the presence of cognitive deficits in organ transplantation candidates. From May 2005 to March 2006, 35 organ transplantation candidates, of mean age 46.71 (+/- 13.01) years, 54.3% including females and 7.29 (+/- 4.22) years mean formal schooling. Of those, 27 (77%) were renal and 8 (23%), liver transplantation candidates. All subjects underwent a neuropsychological assessment battery designed to evaluate attention performance, executive functions, memory, language, visuaospatial, and intellectual skills. We found impairments in attention performance (attention span [34.3%], sustained attention [76.5%], and divided attention [77.8%]), executive functions (category formation [58.3%], errors [61.5%], and perseverative errors [30.4%]), memory (working memory [57.1%], verbal [37.1%] and visual short-term memory [31.4%], verbal [25.7%] and visual long-term memory [51.4], verbal learning [42.9%], interference susceptibility [42.9%], and verbal recognition memory [20.6%]), language (comprehension [38.1%], and vocabulary [30.8%]), visuaospatial (45.8%), and intellectual skills (50.0%). Neuropsychological (cognitive) deficits in transplant candidates are frequent, regardless of the kind of transplantation. The deficits involve several cognitive skills, such as attentional processes, executive functions, memory, language, visuaospatial, and intellectual skills. Therefore, we concluded that a pretransplant neuropsychological assessment is an important measure to detect impairments and to help understand how these difficulties can interfere with patient self-care before and after transplantation.

  2. NASA EM Followup of LIGO-Virgo Candidate Events

    Science.gov (United States)

    Blackburn, Lindy L.

    2011-01-01

    We present a strategy for a follow-up of LIGO-Virgo candidate events using offline survey data from several NASA high-energy photon instruments aboard RXTE, Swift, and Fermi. Time and sky-location information provided by the GW trigger allows for a targeted search for prompt and afterglow EM signals. In doing so, we expect to be sensitive to signals which are too weak to be publicly reported as astrophysical EM events.

  3. Multiplexed mass spectrometry monitoring of biomarker candidates for osteoarthritis.

    Science.gov (United States)

    Fernández-Puente, Patricia; Calamia, Valentina; González-Rodríguez, Lucía; Lourido, Lucía; Camacho-Encina, María; Oreiro, Natividad; Ruiz-Romero, Cristina; Blanco, Francisco J

    2017-01-30

    The methods currently available for the diagnosis and monitoring of osteoarthritis (OA) are very limited and lack sensitivity. Being the most prevalent rheumatic disease, one of the most disabling pathologies worldwide and currently untreatable, there is a considerable interest pointed in the verification of specific biological markers for improving its diagnosis and disease progression studies. Considering the remarkable development of targeted proteomics methodologies in the frame of the Human Proteome Project, the aim of this work was to develop and apply a MRM-based method for the multiplexed analysis of a panel of 6 biomarker candidates for OA encoded by the Chromosome 16, and another 8 proteins identified in previous shotgun studies as related with this pathology, in specimens derived from the human joint and serum. The method, targeting 35 different peptides, was applied to samples from human articular chondrocytes, healthy and osteoarthritic cartilage, synovial fluid and serum. Subsequently, a verification analysis of the biomarker value of these proteins was performed by single point measurements on a set of 116 serum samples, leading to the identification of increased amounts of Haptoglobin and von Willebrand Factor in OA patients. Altogether, the present work provides a tool for the multiplexed monitoring of 14 biomarker candidates for OA, and verifies for the first time the increased amount of two of these circulating markers in patients diagnosed with this disease. We have developed an MRM method for the identification and relative quantification of a panel of 14 protein biomarker candidates for osteoarthritis. This method has been applied to analyze human articular chondrocytes, articular cartilage, synovial fluid, and finally a collection of 116 serum samples from healthy controls and patients suffering different degrees of osteoarthritis, in order to verify the biomarker usefulness of the candidates. HPT and VWF were validated as increased in OA

  4. Light Sensor Candidates for the Cherenkov Telescope Array

    OpenAIRE

    Knoetig, M. L.; Mirzoyan, R.; Kurz, M.; Hose, J.; Lorenz, E.; Schweizer, T.; Teshima, M.; Buzhan, P.; Popova, E.; Bolmont, J.; Tavernet, J. -P.; Vincent, P.; Shayduk, M.

    2011-01-01

    We report on the characterization of candidate light sensors for use in the next-generation Imaging Atmospheric Cherenkov Telescope project called Cherenkov Telescope Array, a major astro-particle physics project of about 100 telescopes that is currently in the prototyping phase. Our goal is to develop with the manufacturers the best possible light sensors (highest photon detection efficiency, lowest crosstalk and afterpulsing). The cameras of those telescopes will be based on classical super...

  5. Genetics of osteoporosis: searching for candidate genes for bone fragility.

    Science.gov (United States)

    Rocha-Braz, Manuela G M; Ferraz-de-Souza, Bruno

    2016-08-01

    The pathogenesis of osteoporosis, a common disease with great morbidity and mortality, comprises environmental and genetic factors. As with other complex disorders, the genetic basis of osteoporosis has been difficult to identify. Nevertheless, several approaches have been undertaken in the past decades in order to identify candidate genes for bone fragility, including the study of rare monogenic syndromes with striking bone phenotypes (e.g. osteogenesis imperfecta and osteopetroses), the analysis of individuals or families with extreme osteoporotic phenotypes (e.g. idiopathic juvenile and pregnancy-related osteoporosis), and, chiefly, genome-wide association studies (GWAS) in large populations. Altogether, these efforts have greatly increased the understanding of molecular mechanisms behind bone remodelling, which has rapidly translated into the development of novel therapeutic strategies, exemplified by the tales of cathepsin K (CTSK) and sclerostin (SOST). Additional biological evidence of involvement in bone physiology still lacks for several candidate genes arisen from GWAS, opening an opportunity for the discovery of new mechanisms regulating bone strength, particularly with the advent of high-throughput genomic technologies. In this review, candidate genes for bone fragility will be presented in comprehensive tables and discussed with regard to how their association with osteoporosis emerged, highlighting key players such as LRP5, WNT1 and PLS3. Current limitations in our understanding of the genetic contribution to osteoporosis, such as yet unidentified genetic modifiers, may be overcome in the near future with better genotypic and phenotypic characterisation of large populations and the detailed study of candidate genes in informative individuals with marked phenotype.

  6. OBAMA. IN HIS OWN WORDS : THE CANDIDATE AND THE PRESIDENT

    OpenAIRE

    Menz, Julian

    2009-01-01

    Purpose/Aim: To study the rhetorical changes in the speeches of Barack Obama from being a presidential candidate to being the President. Material/Method: A rhetorical analysis of two defining speeches using logos, pathos and ethos in conjunction with framing and identity. Main Results: The main result of the essay was that the rhetoric used by Barack Obama did indeed change as his position as a politician changed. This change, however, was the result of how language is affected by circumstanc...

  7. Candido: Uma Leitura Paródica de Candide

    Directory of Open Access Journals (Sweden)

    Maria Gloria Cusumano Mazzi

    2010-12-01

    Full Text Available O presente artigo estuda a leitura paródica que Leonardo Sciascia (1921-1989 faz de Voltaire (1694-1778 mediante o cotejo das obras: o hipertexto Candido ovvero Un sogno fatto in Sicilia (1977 e o hipotexto Candide ou l’optimisme (1759. Apresenta ainda outra possibilidade de leitura, ou seja, Candido como metáfora da própria intertextualidade.

  8. Event display of a H -> 4mu candidate event

    CERN Multimedia

    ATLAS, Collaboration

    2012-01-01

    Event display of a H -> 4mu candidate event with m(4l) = 124.1 (125.1) GeV without (with) Z mass constraint. The masses of the lepton pairs are 86.3 GeV and 31.6 GeV. The event was recorded by ATLAS on 10-Jun-2012, 13:24:31 CEST in run number 204769 as event number 71902630. Muon tracks are colored red.

  9. Event display of a H -> 4mu candidate event

    CERN Multimedia

    ATLAS, Collaboration

    2012-01-01

    Event display of a H -> 4mu candidate event with m(4l) = 124.1 (125.1) GeV without (with) Z mass constraint. The masses of the lepton pairs are 86.3 GeV and 31.6 GeV. The event was recorded by ATLAS on 10-Jun-2012, 13:24:31 CEST in run number 204769 as event number 71902630. Zoom into the tracking detector. Muon tracks are colored red.

  10. Candidate Medical Countermeasures Targeting Ebola Virus Cell Entry

    Science.gov (United States)

    2017-03-31

    antibodies and small molecules [6]. Here, we 26 focus on one aspect of candidate antiviral research , i.e., EBOV cell-entry inhibitors. 27 Ebola virus... Antiviral research 125 1-7 (2016). 604 91. Pécheur EI, Borisevich V, Halfmann P et al. The synthetic antiviral drug arbidol inhibits 605 globally...Weidner T et al. Identification of entry inhibitors of Ebola virus 655 pseudotyped vectors from a myxobacterial compound library. Antiviral research 132

  11. Psychological aptitude evaluation of the special forces candidate.

    Science.gov (United States)

    Genoni, Luca; Jelmini, F; Lang, M; Muggli, F

    2017-02-01

    Changes in recruitment procedures reduced early dismissal rates from Swiss military basic recruitment schools; however, such improvements were not reflected in premature discharge rates from the special forces (SF) (Grenadier) recruitment school. A six-item questionnaire designed to identify recruits likely to be subject to premature dismissal on psychological or psychiatric grounds was developed and prospectively validated. The questionnaire was based on an analysis of medical and psychiatric/psychological records of 26 recruits dismissed from a SF recruitment school. Six items were identified that appeared to have prognostic value for early discharge. These six questions were submitted to the remaining applicants in the recruitment school by a suitably qualified psychologist or psychiatrist and effectively identified candidates who would be discharged early. Based on these results a 0-6 scale was developed and applied prospectively to subsequent Grenadier recruitment courses. Statistical analysis showed that 75% of candidates with the lowest scores would eventually complete the course and that no candidates with highest scores would subsequently complete the recruitment course. Prospective studies in subsequent recruitment courses candidates with high scores were classified as not qualified to enter the course, and those with intermediate scores were subject to additional in-depth interviews with a psychologist or psychiatrist to determine their suitability. In the following courses a correlation was established between the questionnaire score and week of discharge for those discharged. Application of this method during subsequent recruitment courses has reduced early dismissal from Swiss SF recruitment schools. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  12. Identification of candidate genes for dyslexia susceptibility on chromosome 18.

    Directory of Open Access Journals (Sweden)

    Thomas S Scerri

    2010-10-01

    Full Text Available Six independent studies have identified linkage to chromosome 18 for developmental dyslexia or general reading ability. Until now, no candidate genes have been identified to explain this linkage. Here, we set out to identify the gene(s conferring susceptibility by a two stage strategy of linkage and association analysis.Linkage analysis: 264 UK families and 155 US families each containing at least one child diagnosed with dyslexia were genotyped with a dense set of microsatellite markers on chromosome 18. Association analysis: Using a discovery sample of 187 UK families, nearly 3000 SNPs were genotyped across the chromosome 18 dyslexia susceptibility candidate region. Following association analysis, the top ranking SNPs were then genotyped in the remaining samples. The linkage analysis revealed a broad signal that spans approximately 40 Mb from 18p11.2 to 18q12.2. Following the association analysis and subsequent replication attempts, we observed consistent association with the same SNPs in three genes; melanocortin 5 receptor (MC5R, dymeclin (DYM and neural precursor cell expressed, developmentally down-regulated 4-like (NEDD4L.Along with already published biological evidence, MC5R, DYM and NEDD4L make attractive candidates for dyslexia susceptibility genes. However, further replication and functional studies are still required.

  13. Promising new vaccine candidates against Campylobacter in broilers.

    Directory of Open Access Journals (Sweden)

    Marine Meunier

    Full Text Available Campylobacter is the leading cause of human bacterial gastroenteritis in the European Union. Birds represent the main reservoir of the bacteria, and human campylobacteriosis mainly occurs after consuming and/or handling poultry meat. Reducing avian intestinal Campylobacter loads should impact the incidence of human diseases. At the primary production level, several measures have been identified to reach this goal, including vaccination of poultry. Despite many studies, however, no efficient vaccine is currently available. We have recently identified new vaccine candidates using the reverse vaccinology strategy. This study assessed the in vivo immune and protective potential of six newly-identified vaccine antigens. Among the candidates tested on Ross broiler chickens, four (YP_001000437.1, YP_001000562.1, YP_999817.1, and YP_999838.1 significantly reduced cecal Campylobacter loads by between 2 and 4.2 log10 CFU/g, with the concomitant development of a specific humoral immune response. In a second trial, cecal load reductions results were not statistically confirmed despite the induction of a strong immune response. These vaccine candidates need to be further investigated since they present promising features.

  14. ESA M3 mission candidate EChO

    Science.gov (United States)

    Puig, L.; Isaak, K. G.; Escudero, I.; Martin, D.; Crouzet, P.-E.; Rando, N.

    2011-09-01

    The Exoplanet Characterisation Observatory (EChO) is a medium class mission candidate within the science program Cosmic Vision 2015-2025 of the European Space Agency. It was selected in February 2011 as one of 4 M3 mission candidates to enter an assessment phase. The assessment activities start with the definition of science and mission requirements as well as of a preliminary model payload, followed by an internal Concurrent Design Facility (CDF) study. Parallel industrial studies will follow in 2012, after which the 4 missions will be reviewed to identify candidates entering definition phase studies in 2013. EChO aims at characterising the atmosphere of known transiting exoplanets, potentially from giant Hot Jupiters down to Super-Earths orbiting in the habitable zone of M-dwarf stars. It will use a 1 m class telescope, feeding a spectrometer covering the wave lengths from 0.4 to 11 microns with a potential extension to 16 microns. While spatial differentiation of the exoplanet and its host star is not necessary, spectral differentiation will be achieved by making differential measurements of in- and out- of transit frames to cancel the star signal. This paper describes critical requirements, and gives an overview of the model payload design. It also reports on the results of the CDF.

  15. Promising new vaccine candidates against Campylobacter in broilers

    Science.gov (United States)

    Meunier, Marine; Guyard-Nicodème, Muriel; Vigouroux, Estelle; Poezevara, Typhaine; Beven, Véronique; Quesne, S.; Bigault, Lionel; Amelot, Michel; Dory, Daniel

    2017-01-01

    Campylobacter is the leading cause of human bacterial gastroenteritis in the European Union. Birds represent the main reservoir of the bacteria, and human campylobacteriosis mainly occurs after consuming and/or handling poultry meat. Reducing avian intestinal Campylobacter loads should impact the incidence of human diseases. At the primary production level, several measures have been identified to reach this goal, including vaccination of poultry. Despite many studies, however, no efficient vaccine is currently available. We have recently identified new vaccine candidates using the reverse vaccinology strategy. This study assessed the in vivo immune and protective potential of six newly-identified vaccine antigens. Among the candidates tested on Ross broiler chickens, four (YP_001000437.1, YP_001000562.1, YP_999817.1, and YP_999838.1) significantly reduced cecal Campylobacter loads by between 2 and 4.2 log10 CFU/g, with the concomitant development of a specific humoral immune response. In a second trial, cecal load reductions results were not statistically confirmed despite the induction of a strong immune response. These vaccine candidates need to be further investigated since they present promising features. PMID:29176789

  16. Probiotic Candidates from Fish Pond Water in Central Java Indonesia

    Science.gov (United States)

    Harjuno Condro Haditomo, Alfabetian; Desrina; Sarjito; Budi Prayitno, S.

    2018-02-01

    Aeromonas hydrophilla is a major bacterial pathogen of intensive fresh water fish culture in Indonesia. An alternative method to control the pathogen is using probiotics. Probiotics is usually consist of live microorganisms which when administered in adequate amounts confer a health benefits on host. The aim of this research was to determine the probiotic candidates against A. hydrophilla which identified based on the 16S rDNA gene sequences. This research was started with field survey to obtained the probiotic candidate and continue with laboratory experiment. Probiotic candidates were isolated from fish pond water located in Boyolali, and Banjarnegara Regency, Central Java, Indonesia. A total of 133 isolates bacteria were isolated and cultured on to TSA, TSB and GSP medium. Out of 133 isolates only 30 isolates showed inhibition to A.hydrophilla activity. Three promising isolates were identified with PCR using primer for 16S rDNA. Based on 16S rDNA sequence analysis, all three isolates were belong to Bacillus genus. Isolate CKlA21, CKlA28, and CBA14 respectively were closely related to Bacillus sp. 13843 (GenBank accession no. JN874760.1 -100% homology), Bacillus subtilis strain H13 (GenBank accession no.KT907045.1 -- 99% homology), and Bacillus sp. strain 22-4 (GenBank accession no. KX816417.1 -- 97% homology).

  17. THE COOLEST ISOLATED BROWN DWARF CANDIDATE MEMBER OF TWA

    Energy Technology Data Exchange (ETDEWEB)

    Gagné, Jonathan; Lafrenière, David; Doyon, René; Malo, Lison; Artigau, Étienne [Département de Physique and Observatoire du Mont-Mégantic, Université de Montréal, C.P. 6128 Succ. Centre-ville, Montréal, Qc H3C 3J7 (Canada); Faherty, Jacqueline K. [Department of Terrestrial Magnetism, Carnegie Institution of Washington, Washington, DC 20015 (United States); Cruz, Kelle, E-mail: jonathan.gagne@astro.umontreal.ca, E-mail: jfaherty17@gmail.com [Department of Astrophysics, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10034 (United States)

    2014-04-10

    We present two new late-type brown dwarf candidate members of the TW Hydrae association (TWA): 2MASS J12074836-3900043 and 2MASS J12474428-3816464, which were found as part of the BANYAN all-sky survey (BASS) for brown dwarf members of nearby young associations. We obtained near-infrared (NIR) spectroscopy for both objects (NIR spectral types are respectively L1 and M9), as well as optical spectroscopy for J1207-3900 (optical spectral type is L0γ), and show that both display clear signs of low gravity, and thus youth. We use the BANYAN II Bayesian inference tool to show that both objects are candidate members to TWA with a very low probability of being field contaminants, although the kinematics of J1247-3816 seem slightly at odds with that of other TWA members. J1207-3900 is currently the latest-type and the only isolated L-type candidate member of TWA. Measuring the distance and radial velocity of both objects is still required to claim them as bona fide members. Such late-type objects are predicted to have masses down to 11-15 M {sub Jup} at the age of TWA, which makes them compelling targets to study atmospheric properties in a regime similar to that of currently known imaged extrasolar planets.

  18. Five Kepler target stars that show multiple transiting exoplanet candidates

    Energy Technology Data Exchange (ETDEWEB)

    Steffen, Jason H.; /Fermilab; Batalha, Natalie M.; /San Jose State U.; Borucki, William J.; /NASA, Ames; Buchhave, Lars A.; /Harvard-Smithsonian Ctr. Astrophys. /Bohr Inst.; Caldwell, Douglas A.; /NASA, Ames /SETI Inst., Mtn. View; Cochran, William D.; /Texas U.; Endl, Michael; /Texas U.; Fabrycky, Daniel C.; /Harvard-Smithsonian Ctr. Astrophys.; Fressin, Francois; /Harvard-Smithsonian Ctr. Astrophys.; Ford, Eric B.; /Florida U.; Fortney, Jonathan J.; /UC, Santa Cruz, Phys. Dept. /NASA, Ames

    2010-06-01

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities - two near 2:1 and one just outside 5:2. We discuss the implications that multitransiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories; as well as their likely masses and chemical compositions. A Monte Carlo study indicates that, with additional data, most of these systems should exhibit detectable transit timing variations (TTV) due to gravitational interactions - though none are apparent in these data. We also discuss new challenges that arise in TTV analyses due to the presence of more than two planets in a system.

  19. Pulmonary Rehabilitation in Lung Transplant Candidates: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Stefanie Tonguino Rosero

    2013-09-01

    Full Text Available Pulmonary rehabilitation (PR aims to improve physical fitness and to decrease symptoms in patients with chronic lung disease; however there is not clear evidence regarding the benefits of PR in candidates for lung transplantation (LT. Objective. To determine the effectiveness of PR in LT candidates and also to find out how quality of life and exercise tolerance affects the survival of these patients. Methodology. Electronic databases (Medline, Cochrane, PEDro, Scient Direct and SciELO Search of articles in spanish, english or portuguese; controlled clinical trials and cohort studies published between 2000-2011 regarding PR in candidates for LT, the model of Cochrane systematic reviews was used. Results. The papers included were four cohort, two of which regarded of survival pre LT using the six minutes walking test (6MWT; a study of quality of life related to post LT survival and an exercise tolerance study. Controlled clinical trial was not found. Conclusions. The information found in the included studies had clinical and methodological heterogeneity therefore a meta-analysis could not been undertaken. The PR should be considered as an essential part to maintain the exercise tolerance and the patient’s survival. Research regarding this subject is important and should be carried out.

  20. Commentary: Why Pharmaceutical Scientists in Early Drug Discovery Are Critical for Influencing the Design and Selection of Optimal Drug Candidates.

    Science.gov (United States)

    Landis, Margaret S; Bhattachar, Shobha; Yazdanian, Mehran; Morrison, John

    2018-01-01

    This commentary reflects the collective view of pharmaceutical scientists from four different organizations with extensive experience in the field of drug discovery support. Herein, engaging discussion is presented on the current and future approaches for the selection of the most optimal and developable drug candidates. Over the past two decades, developability assessment programs have been implemented with the intention of improving physicochemical and metabolic properties. However, the complexity of both new drug targets and non-traditional drug candidates provides continuing challenges for developing formulations for optimal drug delivery. The need for more enabled technologies to deliver drug candidates has necessitated an even more active role for pharmaceutical scientists to influence many key molecular parameters during compound optimization and selection. This enhanced role begins at the early in vitro screening stages, where key learnings regarding the interplay of molecular structure and pharmaceutical property relationships can be derived. Performance of the drug candidates in formulations intended to support key in vivo studies provides important information on chemotype-formulation compatibility relationships. Structure modifications to support the selection of the solid form are also important to consider, and predictive in silico models are being rapidly developed in this area. Ultimately, the role of pharmaceutical scientists in drug discovery now extends beyond rapid solubility screening, early form assessment, and data delivery. This multidisciplinary role has evolved to include the practice of proactively taking part in the molecular design to better align solid form and formulation requirements to enhance developability potential.

  1. OPTICAL SPECTROSCOPIC OBSERVATIONS OF GAMMA-RAY BLAZAR CANDIDATES. V. TNG, KPNO, AND OAN OBSERVATIONS OF BLAZAR CANDIDATES OF UNCERTAIN TYPE IN THE NORTHERN HEMISPHERE

    Energy Technology Data Exchange (ETDEWEB)

    Álvarez Crespo, N.; Massaro, F. [Dipartimento di Fisica, Università degli Studi di Torino, via Pietro Giuria 1, I-10125 Torino (Italy); Masetti, N. [INAF—Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna, via Gobetti 101, I-40129, Bologna (Italy); Ricci, F.; La Franca, F. [Dipartimento di Matematica e Fisica, Università Roma Tre, via della Vasca Navale 84, I-00146, Roma (Italy); Landoni, M. [INAF-Osservatorio Astronomico di Brera, Via Emilio Bianchi 46, I-23807 Merate (Italy); Patiño-Álvarez, V.; Chavushyan, V.; Torrealba, J. [Instituto Nacional de Astrofisica, Óptica y Electrónica, Apartado Postal 51-216, 72000 Puebla, México (Mexico); D’Abrusco, R.; Paggi, A.; Smith, Howard A. [Harvard—Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138 (United States); Jiménez-Bailón, E. [Instituto de Astronomía, Universidad Nacional Autónoma de México, Apdo. Postal 877, Ensenada, 22800 Baja California, México (Mexico); Latronico, L. [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, I-10125 Torino (Italy); Tosti, G. [Dipartimento di Fisica, Università degli Studi di Perugia, I-06123 Perugia (Italy)

    2016-02-15

    The extragalactic γ-ray sky is dominated by emission from blazars, a peculiar class of active galactic nuclei. Many of the γ-ray sources included in the Fermi-Large Area Telescope Third Source catalog (3FGL) are classified as blazar candidates of uncertain type (BCUs) because there are no optical spectra available in the literature to confirm their nature. In 2013, we started a spectroscopic campaign to look for the optical counterparts of the BCUs and of the unidentified γ-ray sources to confirm their blazar nature. Whenever possible we also determine their redshifts. Here, we present the results of the observations carried out in the northern hemisphere in 2013 and 2014 at the Telescopio Nazionale Galileo, Kitt Peak National Observatory, and Observatorio Astronómico Nacional in San Pedro Mártir. In this paper, we describe the optical spectra of 25 sources. We confirmed that all of the 15 BCUs observed in our campaign and included in our sample are blazars and we estimated the redshifts for three of them. In addition, we present the spectra for three sources classified as BL Lacs in the literature but with no optical spectra available to date. We found that one of them is a quasar (QSO) at a redshift of z = 0.208 and the other two are BL Lacs. Moreover, we also present seven new spectra for known blazars listed in the Roma-BZCAT that have an uncertain redshift or are classified as BL Lac candidates. We found that one of them, 5BZB J0724+2621, is a “changing look” blazar. According to the spectrum available in the literature, it was classified as a BL Lac, but in our observation we clearly detected a broad emission line that led us to classify this source as a QSO at z = 1.17.

  2. ReCGiP, a database of reproduction candidate genes in pigs based on bibliomics.

    Science.gov (United States)

    Yang, Lun; Zhang, Xiangzhe; Chen, Jian; Wang, Qishan; Wang, Lishan; Jiang, Yue; Pan, Yuchun

    2010-08-14

    Reproduction in pigs is one of the most economically important traits. To improve the reproductive performances, numerous studies have focused on the identification of candidate genes. However, it is hard for one to read all literatures thoroughly to get information. So we have developed a database providing candidate genes for reproductive researches in pig by mining and processing existing biological literatures in human and pigs, named as ReCGiP. Based on text-mining and comparative genomics, ReCGiP presents diverse information of reproduction-relevant genes in human and pig. The genes were sorted by the degree of relevance with the reproduction topics and were visualized in a gene's co-occurrence network where two genes were connected if they were co-cited in a PubMed abstract. The 'hub' genes which had more 'neighbors' were thought to be have more important functions and could be identified by the user in their web browser. In addition, ReCGiP provided integrated GO annotation, OMIM and biological pathway information collected from the Internet. Both pig and human gene information can be found in the database, which is now available. ReCGiP is a unique database providing information on reproduction related genes for pig. It can be used in the area of the molecular genetics, the genetic linkage map, and the breeding of the pig and other livestock. Moreover, it can be used as a reference for human reproduction research.

  3. THE FREQUENT USE OF TEACHING STRATEGIES/METHODS AMONG TEACHERS ACCORDING TO THE TEACHER CANDIDATES OBSERVATION

    Directory of Open Access Journals (Sweden)

    Mukaddes SAKALLI

    2007-06-01

    Full Text Available The aim of this study is to show the frequent use of teaching stratergies/methods amongteachers which has been observed by teacher candidates currently undergoing their own field/area teaching program.This study undertakes the general research model and the tools used to obtain the necessary data are personalinformation form and a questionaire. “Teachers frequent use of teaching methods/stratergies” to obtain necessarydata a 4 likert scale type of questionaire has been used. The scale developed on behalf of the researcher involves 35teaching methods/stratergies.The data obtained through 71 quetionaires where evaluated from 4 (always and 1(none as points and has been evaluated through the SPSS package program. In addition, the resultsof the data havebeen analysed through the following techniques: percentage (%, average (X and standard deviation (SS.According to the observations made by the teacher candidates the following teaching methods/stratergies wereundertaken by the teachers according to thier teaching field: lecturing, question-answer method were always used,homework, practice in the classroom, problem solving, showing and practicing methods were frequently used,project work, anaylsing example situations, debates, similarity, computer based education, observing privatetutorials, eduational games, cooperative learning, brainstroming, field trips and reflecting/miroring situations,group/team work, experiment, role play, micro-learning technique, statement, speech,meeting, display, drama,conference, formal debates, sempozium, seminar, panel, umbrella technique, forum and opposite panel

  4. [Potential improvements in medical education as retrospectively evaluated by candidates for specialist examinations].

    Science.gov (United States)

    Hofer, M; Jansen, M; Soboll, S

    2006-02-24

    As part of the new regulations for licensing doctors there have been numerous attempts at reform by many medical faculties to consider interdisciplinary linkage of the curriculum with emphasis on teaching of small groups of students. This study was undertaken to help answer the question of how much weight should be given to the various subjects and what resources are needed for any reformed curriculum and what key areas of competence need to be given greater importance. 1029 candidates of specialist examinations of the Medical Council of North-Rhine in 2002 and 2003 filled in questionnaires to evaluate retrospectively the actual relevance of individual preclinical and clinical subjects, courses and areas of practical competence to their further medical education and related potentials for improvement in their studies. The participants were from 5 medical faculties in the North-Rhine area of Germany. They were also asked about methods of examination that were effective in aiding their learning behaviour. Those answering the questionnaire considered especially chemistry and physics as well as environmental, occupational and forensic medicine, bio-mathematics, radiotherapy and nuclear medicine among the less relevant subjects. On the other hand, anatomy, physiology, internal medicine, pharmacology and surgery were considered especially relevant. The greatest deficiencies in most of the medical curricula as taught in the North-Rhine medical courses are in the areas of competence in communication and practical clinical skills. Members of this group also pleaded for an increased use of standardized objective structured clinical examinations (OSCE).

  5. Do candidate reactions relate to job performance or affect criterion-related validity? A multistudy investigation of relations among reactions, selection test scores, and job performance.

    Science.gov (United States)

    McCarthy, Julie M; Van Iddekinge, Chad H; Lievens, Filip; Kung, Mei-Chuan; Sinar, Evan F; Campion, Michael A

    2013-09-01

    Considerable evidence suggests that how candidates react to selection procedures can affect their test performance and their attitudes toward the hiring organization (e.g., recommending the firm to others). However, very few studies of candidate reactions have examined one of the outcomes organizations care most about: job performance. We attempt to address this gap by developing and testing a conceptual framework that delineates whether and how candidate reactions might influence job performance. We accomplish this objective using data from 4 studies (total N = 6,480), 6 selection procedures (personality tests, job knowledge tests, cognitive ability tests, work samples, situational judgment tests, and a selection inventory), 5 key candidate reactions (anxiety, motivation, belief in tests, self-efficacy, and procedural justice), 2 contexts (industry and education), 3 continents (North America, South America, and Europe), 2 study designs (predictive and concurrent), and 4 occupational areas (medical, sales, customer service, and technological). Consistent with previous research, candidate reactions were related to test scores, and test scores were related to job performance. Further, there was some evidence that reactions affected performance indirectly through their influence on test scores. Finally, in no cases did candidate reactions affect the prediction of job performance by increasing or decreasing the criterion-related validity of test scores. Implications of these findings and avenues for future research are discussed. PsycINFO Database Record (c) 2013 APA, all rights reserved

  6. NeuroRDF: semantic integration of highly curated data to prioritize biomarker candidates in Alzheimer's disease.

    Science.gov (United States)

    Iyappan, Anandhi; Kawalia, Shweta Bagewadi; Raschka, Tamara; Hofmann-Apitius, Martin; Senger, Philipp

    2016-07-08

    Neurodegenerative diseases are incurable and debilitating indications with huge social and economic impact, where much is still to be learnt about the underlying molecular events. Mechanistic disease models could offer a knowledge framework to help decipher the complex interactions that occur at molecular and cellular levels. This motivates the need for the development of an approach integrating highly curated and heterogeneous data into a disease model of different regulatory data layers. Although several disease models exist, they often do not consider the quality of underlying data. Moreover, even with the current advancements in semantic web technology, we still do not have cure for complex diseases like Alzheimer's disease. One of the key reasons accountable for this could be the increasing gap between generated data and the derived knowledge. In this paper, we describe an approach, called as NeuroRDF, to develop an integrative framework for modeling curated knowledge in the area of complex neurodegenerative diseases. The core of this strategy lies in the usage of well curated and context specific data for integration into one single semantic web-based framework, RDF. This increases the probability of the derived knowledge to be novel and reliable in a specific disease context. This infrastructure integrates highly curated data from databases (Bind, IntAct, etc.), literature (PubMed), and gene expression resources (such as GEO and ArrayExpress). We illustrate the effectiveness of our approach by asking real-world biomedical questions that link these resources to prioritize the plausible biomarker candidates. Among the 13 prioritized candidate genes, we identified MIF to be a potential emerging candidate due to its role as a pro-inflammatory cytokine. We additionally report on the effort and challenges faced during generation of such an indication-specific knowledge base comprising of curated and quality-controlled data. Although many alternative approaches

  7. Determining Candidate Single Nucleotide Polymorphisms in Acquired Laryngotracheal Stenosis.

    Science.gov (United States)

    Anis, Mursalin M; Krynetskaia, Natalia; Zhao, Zhigen; Krynetskiy, Evgeny; Soliman, Ahmed M S

    2018-03-01

    Despite wide adoption of strategies to prevent injury from prolonged intubation and tracheotomy, acquired laryngotracheal stenosis (ALTS) has not disappeared. ALTS' persistence may be due to patient factors that confer unique susceptibility for some. We sought to identify genetic markers in genes associated with wound healing that could be associated with ALTS. Case-control study. One hundred thirty-eight patients were recruited, 53 patients with ALTS and 85 control patients who underwent intubation or tracheotomy without evidence of ALTS. The patients' DNA was isolated from whole blood. Custom primers were designed, and the TaqMan assay employing allele-specific polymerase chain reaction was used to interrogate single nucleotide polymorphisms (SNPs) rs1799750, rs522616, rs2276109, rs2569190, rs1800469, and rs1024611 of candidate wound healing genes MMP1, MMP3, MMP12, CD14, TGFβ1, and MCP1, respectively. A logistic regression model was used to examine the association of candidate gene polymorphisms with the presence or absence of ALTS. All 138 patients were successfully genotyped. No significant association was found between candidate SNPs and development of ALTS in the overall group. However, subgroup analysis within each ethnicity identified SNPs that are associated with ALTS depending upon the ethnic background. Patient factors such as variations in wound healing due to functional SNPs may shed light on the development of ALTS. There may be a difference in susceptibility to developing ALTS in different ethnic backgrounds. These preliminary findings need to be corroborated in larger population studies. 3b. Laryngoscope, 128:E111-E116, 2018. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

  8. Psychometric Evaluation of Disordered Eating Measures in Bariatric Surgery Candidates.

    Science.gov (United States)

    Parker, Katrina; Mitchell, Sarah; O'Brien, Paul; Brennan, Leah

    2016-03-01

    Assessment of disordered eating is common in bariatric surgery candidates, yet psychometric properties of disordered eating measures in this population are largely unknown. Measures were completed by 405 adult bariatric surgery candidates at pre-surgical consultation. Fit of the original scale structures was tested using confirmatory factor analysis (CFA) and alternative factor solutions were generated using exploratory factor analysis (EFA). Reliability (internal consistency), construct validity (convergent and divergent) and criterion validity (with the EDE as criterion) were assessed. The measures prioritised for evaluation are the following: Eating Disorder Examination Questionnaire (EDE-Q; n = 405), Three-Factor Eating Questionnaire (TFEQ; n = 405), Questionnaire of Eating and Weight Patterns Revised (QEWP-R; n = 204), Clinical Impairment Assessment (CIA; n = 204) and the Eating Disorder Examination clinical interview (EDE; n = 131). CFA revealed adequate fit for only the CIA in its current form (CFI = 0.925, RMSEA = 0.096). EFA produced revised scales with improved reliability for the EDE, EDE-Q and TFEQ. Reliability of revised subscales was improved (original scales α = 0.43-0.82; revised scales α = 0.67-0.93). Correlational analyses of the CIA and revised versions of remaining scales with measures of psychological wellbeing and impairment revealed adequate convergent validity. All measures differentiated an EDE-classified disordered eating group from a non-disordered eating group (criterion validity). Diagnostic concordance between the EDE, EDE-Q and QEWP-R was low, and identification of disordered eating behaviours was inconsistent across measures. Findings highlight the limitations of existing disordered eating questionnaires in bariatric surgery candidates. Results suggest revised assessments are required to overcome these limitations and ensure that measures informing clinical recommendations regarding patient care are reliable and valid.

  9. Vaccine candidate discovery for the next generation of malaria vaccines.

    Science.gov (United States)

    Tuju, James; Kamuyu, Gathoni; Murungi, Linda M; Osier, Faith H A

    2017-10-01

    Although epidemiological observations, IgG passive transfer studies and experimental infections in humans all support the feasibility of developing highly effective malaria vaccines, the precise antigens that induce protective immunity remain uncertain. Here, we review the methodologies applied to vaccine candidate discovery for Plasmodium falciparum malaria from the pre- to post-genomic era. Probing of genomic and cDNA libraries with antibodies of defined specificities or functional activity predominated the former, whereas reverse vaccinology encompassing high throughput in silico analyses of genomic, transcriptomic or proteomic parasite data sets is the mainstay of the latter. Antibody-guided vaccine design spanned both eras but currently benefits from technological advances facilitating high-throughput screening and downstream applications. We make the case that although we have exponentially increased our ability to identify numerous potential vaccine candidates in a relatively short space of time, a significant bottleneck remains in their validation and prioritization for evaluation in clinical trials. Longitudinal cohort studies provide supportive evidence but results are often conflicting between studies. Demonstration of antigen-specific antibody function is valuable but the relative importance of one mechanism over another with regards to protection remains undetermined. Animal models offer useful insights but may not accurately reflect human disease. Challenge studies in humans are preferable but prohibitively expensive. In the absence of reliable correlates of protection, suitable animal models or a better understanding of the mechanisms underlying protective immunity in humans, vaccine candidate discovery per se may not be sufficient to provide the paradigm shift necessary to develop the next generation of highly effective subunit malaria vaccines. © 2017 The Authors. Immunology Published by John Wiley & Sons Ltd.

  10. Three candidate double clusters in the LMC: truth or dare?

    Science.gov (United States)

    Dalessandro, Emanuele; Zocchi, Alice; Varri, Anna Lisa; Mucciarelli, Alessio; Bellazzini, Michele; Ferraro, Francesco R.; Lanzoni, Barbara; Lapenna, Emilio; Origlia, Livia

    2018-02-01

    The Large Magellanic Cloud (LMC) hosts a large number of candidate stellar cluster pairs. Binary stellar clusters provide important clues about cluster formation processes and the evolutionary history of the host galaxy. However, to properly extract and interpret this information, it is crucial to fully constrain the fraction of real binary systems and their physical properties. Here we present a detailed photometric analysis based on ESO-FORS2 images of three candidate cluster multiplets in the LMC, namely SL349-SL353, SL385-SL387-NGC 1922 and NGC 1836-BRHT4b-NGC 1839. For each cluster, we derived ages, structural parameters and morphological properties. We have also estimated the degree of filling of their Roche lobe, as an approximate tool to measure the strength of the tidal perturbations induced by the LMC. We find that the members of the possible pairs SL349-SL353 and BRHT4b-NGC 1839 have a similar age (t = 1.00 ± 0.12 Gyr and t = 140 ± 15 Myr, respectively), thus possibly hinting at a common origin of their member systems. We also find that all candidate pairs in our sample show evidence of intracluster overdensities that can be a possible indication of real binarity. Particularly interesting is the case of SL349-SL353. In fact, SL353 is relatively close to the condition of critical filling, thus suggesting that these systems might actually constitute an energetically bound pair. It is therefore key to pursue a detailed kinematic screening of such clusters, without which, at present, we do not dare making a conclusive statement about the true nature of this putative pair.

  11. Modelling groundwater discharge areas using only digital elevation models as input data

    International Nuclear Information System (INIS)

    Brydsten, Lars

    2006-10-01

    Advanced geohydrological models require data on topography, soil distribution in three dimensions, vegetation, land use, bedrock fracture zones. To model present geohydrological conditions, these factors can be gathered with different techniques. If a future geohydrological condition is modelled in an area with positive shore displacement (say 5,000 or 10,000 years), some of these factors can be difficult to measure. This could include the development of wetlands and the filling of lakes. If the goal of the model is to predict distribution of groundwater recharge and discharge areas in the landscape, the most important factor is topography. The question is how much can topography alone explain the distribution of geohydrological objects in the landscape. A simplified description of the distribution of geohydrological objects in the landscape is that groundwater recharge areas occur at local elevation curvatures and discharge occurs in lakes, brooks, and low situated slopes. Areas in-between these make up discharge areas during wet periods and recharge areas during dry periods. A model that could predict this pattern only using topography data needs to be able to predict high ridges and future lakes and brooks. This study uses GIS software with four different functions using digital elevation models as input data, geomorphometrical parameters to predict landscape ridges, basin fill for predicting lakes, flow accumulations for predicting future waterways, and topographical wetness indexes for dividing in-between areas based on degree of wetness. An area between the village of and Forsmarks' Nuclear Power Plant has been used to calibrate the model. The area is within the SKB 10-metre Elevation Model (DEM) and has a high-resolution orienteering map for wetlands. Wetlands are assumed to be groundwater discharge areas. Five hundred points were randomly distributed across the wetlands. These are potential discharge points. Model parameters were chosen with the

  12. Modelling groundwater discharge areas using only digital elevation models as input data

    Energy Technology Data Exchange (ETDEWEB)

    Brydsten, Lars [Umeaa Univ. (Sweden). Dept. of Biology and Environmental Science

    2006-10-15

    Advanced geohydrological models require data on topography, soil distribution in three dimensions, vegetation, land use, bedrock fracture zones. To model present geohydrological conditions, these factors can be gathered with different techniques. If a future geohydrological condition is modelled in an area with positive shore displacement (say 5,000 or 10,000 years), some of these factors can be difficult to measure. This could include the development of wetlands and the filling of lakes. If the goal of the model is to predict distribution of groundwater recharge and discharge areas in the landscape, the most important factor is topography. The question is how much can topography alone explain the distribution of geohydrological objects in the landscape. A simplified description of the distribution of geohydrological objects in the landscape is that groundwater recharge areas occur at local elevation curvatures and discharge occurs in lakes, brooks, and low situated slopes. Areas in-between these make up discharge areas during wet periods and recharge areas during dry periods. A model that could predict this pattern only using topography data needs to be able to predict high ridges and future lakes and brooks. This study uses GIS software with four different functions using digital elevation models as input data, geomorphometrical parameters to predict landscape ridges, basin fill for predicting lakes, flow accumulations for predicting future waterways, and topographical wetness indexes for dividing in-between areas based on degree of wetness. An area between the village of and Forsmarks' Nuclear Power Plant has been used to calibrate the model. The area is within the SKB 10-metre Elevation Model (DEM) and has a high-resolution orienteering map for wetlands. Wetlands are assumed to be groundwater discharge areas. Five hundred points were randomly distributed across the wetlands. These are potential discharge points. Model parameters were chosen with the

  13. Development and evaluation of candidate high-level waste forms

    International Nuclear Information System (INIS)

    Bernadzikowski, T.A.

    1981-01-01

    Some seventeen candidate waste forms have been investigated under US Department of Energy programs as potential media for the immobilization and geologic disposal of the high-level radioactive wastes (HLW) resulting from chemical processing of nuclear reactor fuels and targets. Two of these HLW forms were selected at the end of fiscal year (FY) 1981 for intensive development if FY 1982 to 1983. Borosilicate glass was continued as the reference form. A crystalline ceramic waste form, SYNROC, was selected for further product formulation and process development as the alternative to borosilicate glass. This paper describes the bases on which this decision was made

  14. A double candidate survivable routing protocol for HAP network

    Science.gov (United States)

    He, Panfeng; Li, Chunyue; Ni, Shuyan

    2016-11-01

    To improve HAP network invulnerability, and at the same time considering the quasi-dynamic topology in HAP network, a simple and reliable routing protocol is proposed in the paper. The protocol firstly uses a double-candidate strategy for the next-node select to provide better robustness. Then during the maintenance stage, short hello packets instead of long routing packets are used only to check link connectivity in the quasi-dynamic HAP network. The route maintenance scheme based on short hello packets can greatly reduce link spending. Simulation results based on OPNET demonstrate the effectiveness of the proposed routing protocol.

  15. Candidate z~8-9 Galaxies from WFC3 Imaging

    OpenAIRE

    Lorenzoni, Silvio; Bunker, Andrew; Wilkins, Stephen; Stanway, Elizabeth; Jarvis, Matt; Caruana, Joseph

    2010-01-01

    We present a search for galaxies at 7.6 < z < 9.8 using the latest Hubble Space Telescope/Wide Field Camera 3 (WFC3) near-infrared data, based on the Lyman-break technique. We search for galaxies which have large (Y−J) colours (the ‘Y-drops’) on account of the Lyman α forest absorption, and with (J−H) colours inconsistent with being low-redshift contaminants. We identify 24 candidates at redshift z≈ 8–9 (15 are robust and a further nine more marginal but consistent with being high redshift) o...

  16. The surgical residency interview: a candidate-centered, working approach.

    Science.gov (United States)

    Seabott, Heather; Smith, Ryan K; Alseidi, Adnan; Thirlby, Richard C

    2012-01-01

    The interview process is a pivotal, differentiating component of the residency match. Our bias is toward a working interview, producing better fulfillment of the needs of both parties, and a more informed match selection for the candidates and program. We describe a "candidate-centered" approach for integrating applicant interviews into our daily work schedule. Applicants are informed upon accepting the interview of the working interview model. Our program offers 33 interview days over a 12-week period. A maximum of 5 applicants are hosted per day. Applicants are assigned to 1 of our general, thoracic, vascular, or plastic surgery teams. The interview day begins with the applicant changing into scrubs, attending a morning conference, and taking part in a program overview by a Chief Resident. Applicants join their host team where 4-8 hours are spent observing the operative team, on rounds and sharing lunch. The faculty and senior residents are responsible for interviewing and evaluating applicants though the Electronic Residency Application Service. A total of 13 surgeons are involved in the interview process resulting in broad-based evaluations. Each surgeon interviewed between 3 and 12 applicants. Faculty rate this interview approach highly because it allows them to maintain a rigorous operative schedule while interacting with applicants. Current residents are engaged in welcoming applicants to view the program. Faculty and residents believe cooperating in a real world manner aids their assessment of the applicant. Applicants routinely provide positive feedback, relaying this approach is informative, transparent, and should be the "standard." Applicants believe they are presented a realistic view of the program. Ultimately, this candidate-centered process may be attributable to our resident cohort who exhibit high satisfaction, excellent resident morale, and very low dropout rate. We present a candidate-centered, working interview approach used in the selection of

  17. The genetics of reading disabilities: from phenotypes to candidate genes.

    Science.gov (United States)

    Raskind, Wendy H; Peter, Beate; Richards, Todd; Eckert, Mark M; Berninger, Virginia W

    2012-01-01

    This article provides an overview of (a) issues in definition and diagnosis of specific reading disabilities at the behavioral level that may occur in different constellations of developmental and phenotypic profiles (patterns); (b) rapidly expanding research on genetic heterogeneity and gene candidates for dyslexia and other reading disabilities; (c) emerging research on gene-brain relationships; and (d) current understanding of epigenetic mechanisms whereby environmental events may alter behavioral expression of genetic variations. A glossary of genetic terms (denoted by bold font) is provided for readers not familiar with the technical terms.

  18. Event display of a H -> 4e candidate event

    CERN Multimedia

    ATLAS, Collaboration

    2012-01-01

    Event display of a H -> 4e candidate event with m(4l) = 124.5 (124.6) GeV without (with) Z mass constraint. The masses of the lepton pairs are 70.6 GeV and 44.7 GeV. The event was recorded by ATLAS on 18-May-2012, 20:28:11 CEST in run number 203602 as event number 82614360. The tracks of the two electron pairs are colored red, the clusters in the LAr calorimeter are colored darkgreen.

  19. Event display of a H -> 4e candidate event

    CERN Multimedia

    ATLAS, Collaboration

    2012-01-01

    Event display of a H -> 4e candidate event with m(4l) = 124.5 (124.6) GeV without (with) Z mass constraint. The masses of the lepton pairs are 70.6 GeV and 44.7 GeV. The event was recorded by ATLAS on 18-May-2012, 20:28:11 CEST in run number 203602 as event number 82614360. Zoom into the tracking detector and the LAr calorimeter where its detailed structure is highlighted. The tracks and clusters of the two electron pairs are colored red and blue, respectively.

  20. Event display of a H -> 4e candidate event

    CERN Multimedia

    ATLAS, Collaboration

    2012-01-01

    Event display of a H -> 4e candidate event with m(4l) = 124.5 (124.6) GeV without (with) Z mass constraint. The masses of the lepton pairs are 70.6 GeV and 44.7 GeV. The event was recorded by ATLAS on 18-May-2012, 20:28:11 CEST in run number 203602 as event number 82614360. The tracks and clusters of the two electron pairs are colored red and blue, respectively.

  1. Event display of a H -> 4e candidate event

    CERN Multimedia

    ATLAS, Collaboration

    2012-01-01

    Event display of a H -> 4e candidate event with m(4l) = 124.5 (124.6) GeV without (with) Z mass constraint. The masses of the lepton pairs are 70.6 GeV and 44.7 GeV. The event was recorded by ATLAS on 18-May-2012, 20:28:11 CEST in run number 203602 as event number 82614360. Zoom into the tracking detector. The tracks and clusters of the two electron pairs are colored red and blue, respectively.

  2. Event display of a H -> 4mu candidate event

    CERN Multimedia

    ATLAS, Collaboration

    2012-01-01

    Event display of a H -> 4mu candidate event with m(4l) = 124.1 (125.1) GeV without (with) Z mass constraint. The masses of the lepton pairs are 86.3 GeV and 31.6 GeV. The event was recorded by ATLAS on 10-Jun-2012, 13:24:31 CEST in run number 204769 as event number 71902630. Muon tracks are colored red. The inset on the right-hand side shows a zoom into the tracking detector. The inset on top shows a zoom into the vertex region, indicating that the 4 muons originate from the same primary vertex.

  3. Experience with CANDID: Comparison algorithm for navigating digital image databases

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, P.; Cannon, M.

    1994-10-01

    This paper presents results from the authors experience with CANDID (Comparison Algorithm for Navigating Digital Image Databases), which was designed to facilitate image retrieval by content using a query-by-example methodology. A global signature describing the texture, shape, or color content is first computed for every image stored in a database, and a normalized similarity measure between probability density functions of feature vectors is used to match signatures. This method can be used to retrieve images from a database that are similar to a user-provided example image. Results for three test applications are included.

  4. The rhesus monkey (Macaca mulatta) as a flight candidate

    Science.gov (United States)

    Debourne, M. N. G.; Bourne, G. H.; Mcclure, H. M.

    1977-01-01

    The intelligence and ruggedness of rhesus monkeys, as well as the abundance of normative data on their anatomy, physiology, and biochemistry, and the availability of captive bred animals qualify them for selection as candidates for orbital flight and weightlessness studies. Baseline data discussed include: physical characteristics, auditory thresholds, visual accuity, blood, serological taxomony, immunogenetics, cytogenics, circadian rhythms, respiration, cardiovascular values, corticosteroid response to charr restraint, microscopy of tissues, pathology, nutrition, and learning skills. Results from various tests used to establish the baseline data are presented in tables.

  5. A comparative study of oral candidal species carriage in patients with type1 and type2 diabetes mellitus

    Science.gov (United States)

    Shenoy, Mangesh P; Puranik, Rudrayya S; Vanaki, Shrinivas S; Puranik, Surekha R; Shetty, Pushparaja; Shenoy, Radhika

    2014-01-01

    Context: Diabetes mellitus can have profound effects upon the oral tissues especially in patients with poor glycemic control being prone to severe and/or recurrent infections particularly candidiasis. The main aim was to study the association between Type 1 and Type 2 diabetes mellitus and candidal carriage. Materials and Methods: The study design comprised of previously diagnosed 30 patients each with type 1 diabetes mellitus (Group A) and type 2 diabetes mellitus (Group B) and 30 age-, sex- and dental status-matched healthy non-diabetic individuals as controls (Group C). The saliva samples were collected and inoculated onto Sabouraud dextrose agar (SDA) and chromogenic agar culture medium. Candidal colony forming units per ml (CFU/ml) values were determined. Statistical Analysis: Data were analyzed by χ2 test, Mann-Whitney U-test, Spearman's rank correlation and Karl Pearson's correlation coefficient. Results: Data analysis showed statistically significant higher positive candidal growth in Group A and Group B when compared to Group C. The CFU/ml values were significantly higher in Groups A and B as compared with Group C. Significant positive correlation of CFU/ml with fasting blood sugar level and HbA1c% in both Groups A and B was seen. Oral signs and symptoms observed in diabetics were dry mouth, burning sensation, fissuring and atrophic changes of tongue and erythematous areas, which positively correlated with candidal load. Conclusion: The glycemic control status of the diabetic patients may directly influence candidal colonization. The quantitative and biochemical characterization allows better insight into the study of association of diabetes mellitus and candida. PMID:25364182

  6. Variable-density groundwater flow simulations and particle tracking. Numerical modelling using DarcyTools. Preliminary site description of the Simpevarp area, version 1.1

    Energy Technology Data Exchange (ETDEWEB)

    Follin, Sven [SF GeoLogic AB, Stockholm (Sweden); Stigsson, Martin; Berglund, Sten [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Svensson, Urban [Computer-aided Fluid Engineering AB, Norrkoeping (Sweden)

    2004-12-01

    SKB is conducting site investigations for a high-level nuclear waste repository in fractured crystalline rocks at two coastal areas in Sweden, Forsmark and Simpevarp. The investigations started in 2002 and have been planned since the late 1990s. The work presented here investigates the possibility of using hydrogeochemical measurements in deep boreholes to reduce parameter uncertainty in a regional modelling of groundwater flow in fractured rock. The work was conducted with the aim of improving the palaeohydrogeological understanding of the Simpevarp area and to give recommendations to the preparations of the next version of the Preliminary Site Description (1.2). The study is based on a large number of numerical simulations of transient variable density groundwater flow through a strongly heterogeneous and anisotropic medium. The simulations were conducted with the computer code DarcyTools, the development of which has been funded by SKB. DarcyTools is a flexible porous media code specifically designed to treat groundwater flow and salt transport in sparsely fractured crystalline rock and it is noted that some of the features presented in this report are still under development or subjected to testing and verification. The simulations reveal the sensitivity of the results to different hydrogeological modelling assumptions, e.g. the sensitivity to the initial groundwater conditions at 10,000 BC, the size of the model domain and boundary conditions, and the hydraulic properties of deterministically and stochastically modelled deformation zones. The outcome of these simulations was compared with measured salinities and calculated relative proportions of different water types (mixing proportions) from measurements in two deep core drilled boreholes in the Laxemar subarea. In addition to the flow simulations, the statistics of flow related transport parameters were calculated for particle flowpaths from repository depth to ground surface for two subareas within the

  7. Genome-wide scan for visceral leishmaniasis in mixed-breed dogs identifies candidate genes involved in T helper cells and macrophage signaling

    Science.gov (United States)

    We conducted a genome-wide scan for visceral leishmaniasis in mixed-breed dogs from a highly endemic area in Brazil using 149,648 single nucleotide polymorphism (SNP) markers genotyped in 20 cases and 28 controls. Using a mixed model approach, we found two candidate loci on canine autosomes 1 and 2....

  8. No Evidence for the Association between a Polymorphism in the PCLO Depression Candidate Gene with Memory Bias in Remitted Depressed Patients and Healthy Individuals

    NARCIS (Netherlands)

    Vrijsen, J.N.; Speckens, A.E.M.; Arias Vasquez, A.; Franke, B.; Becker, E.S.; Oostrom, I.I.H. van

    2014-01-01

    The PCLO rs2522833 candidate polymorphism for depression has been associated to monoaminergic neurotransmission. In healthy and currently depressed individuals, the polymorphism has been found to affect activation of brain areas during memory processing, but no direct association of PCLO with memory

  9. CVExplorer: identifying candidate developers by mining and exploring their open source contributions.

    CSIR Research Space (South Africa)

    Greene, GJ

    2016-09-01

    Full Text Available demonstrate the usefulness of CVExplorer by using it to recommend candidates for open positions in two companies. Keywords Identifying candidate developers, Developer skills identication, Mining software repositories ...

  10. 77 FR 27057 - Request for Nominations of Drinking Water Contaminants for the Fourth Contaminant Candidate List

    Science.gov (United States)

    2012-05-08

    ... Drinking Water Contaminants for the Fourth Contaminant Candidate List AGENCY: Environmental Protection... Agency (EPA) is requesting nominations of chemical and microbial contaminants for possible inclusion in the fourth drinking water Contaminant Candidate List (CCL 4). EPA is also requesting supporting...

  11. Estimated transportation routes to a candidate salt repository site in Deaf Smith County, Texas

    International Nuclear Information System (INIS)

    Joy, D.S.; Johnson, P.E.

    1987-10-01

    This report presents a preliminary analysis of possible highway and rail transportation routes within Texas, Oklahoma, and New Mexico for shipments of spent fuel to the candidate repository site in Deaf Smith County, Texas. Two cases are examined for highway shipments. The initial case analyzes shipments following the Department of Transportation's HM-164 regulations for shipment of spent fuel. The second case analyzes normal commercial routes. Three rail cases are also examined. Each case analyzes potential routes that would be used based for different access spurs into the repository site. Two appendices are included which examine additional scenarios generated by restricting routes from passing through various metropolitan areas. The major finding is that most shipments to the Deaf Smith site will pass through Amarillo, Texas. There are few, if any, feasible alternative routes which would significantly reduce the amount of traffic passing through Amarillo

  12. Survey of degradation modes of candidate materials for high-level radioactive-waste disposal containers

    International Nuclear Information System (INIS)

    Strum, M.J.; Weiss, H.; Farmer, J.C.; Bullen, D.B.

    1988-06-01

    This volume surveys the effects of welding on the degradation modes of three austenitic alloys: Types 304L and 316L stainless steels and Alloy 825. These materials are candidates for the fabrication of containers for the long-term storage of high-level nuclear waste. The metallurgical characteristics of fusion welds are reviewed here and related to potential degradation modes of the containers. Three specific areas are discussed in depth: (1) decreased resistance to corrosion in the forms of preferential corrosion, sensitization, and susceptibility to stress corrosion cracking, (2) hot cracking in the heat-affected zone and the weld zone, and (3) formation of intermetallic phases. The austenitic alloys are ranked as follows in terms of overall weldability: Alloy 825 (best) > Type 316L stainless steel > Type 304L stainless steel (worst). 108 refs., 31 figs., 7 tabs

  13. Identification of single nucleotide polymorphisms (SNPs at candidate genes involved in abiotic stress in two Prosopis species of hybrids

    Directory of Open Access Journals (Sweden)

    Maria F. Pomponio

    2014-12-01

    Full Text Available Aim of the study: Identify and compare SNPs on candidate genes related to abiotic stress in Prosopis chilensis, Prosopis flexuosa and interspecific hybridsArea of the study: Chaco árido, Argentina. Material and Methods: Fragments from 6 candidate genes were sequenced in 60 genotypes. DNA polymorphisms were analyzed.Main Results: The analysis revealed that the hybrids had the highest rate of polymorphism, followed by P. flexuosa and P. chilensis, the values found are comparable to other forest tree species.Research highlights: This approach will help to study genetic diversity variation on natural populations for assessing the effects of environmental changes.Keywords: SNPs; abiotic stress; interspecific variation; molecular markers. 

  14. Measurement of Ambient Air Particle (TSP, PM10, PM2,5) Around Candidate Location of PLTN Semenanjung Lemahabang

    International Nuclear Information System (INIS)

    AgusGindo S; Budi Hari H

    2008-01-01

    Measurement analysis of ambient air particle (TSP, PM 10 , PM 2,5 ) around location candidate of PLTN (Power Station of Nuclear Energy) Semenanjung Lemahabang has been carried out. The measurement was conducted in May 2007 with a purpose to providing information about concentration of ambient air particle (TSP, PM 10 , PM 2,5 ) and diameter distribution of its air particle. The measurement was conducted in three locations i.e. 1). Balong village 2). Bayuran 3). Bondo. Concentration of TSP, PM 10 , and PM 2,5 per 24 hours in all measured locations in area candidate of PLTN exceed quality standard of national ambient air is specified by government. All measurement locations for the TSP, PM 10 , and PM 2,5 was include category of ISPU (Standard Index of Air Pollution) moderate. (author)

  15. Transmission blocking malaria vaccines: Assays and candidates in clinical development.

    Science.gov (United States)

    Sauerwein, R W; Bousema, T

    2015-12-22

    Stimulated by recent advances in malaria control and increased funding, the elimination of malaria is now considered to be an attainable goal for an increasing number of malaria-endemic regions. This has boosted the interest in transmission-reducing interventions including vaccines that target sexual, sporogenic, and/or mosquito-stage antigens to interrupt malaria transmission (SSM-VIMT). SSM-VIMT aim to prevent human malaria infection in vaccinated communities by inhibiting parasite development within the mosquito after a blood meal taken from a gametocyte carrier. Only a handful of target antigens are in clinical development and progress has been slow over the years. Major stumbling blocks include (i) the expression of appropriately folded target proteins and their downstream purification, (ii) insufficient induction of sustained functional blocking antibody titers by candidate vaccines in humans, and (iii) validation of a number of (bio)-assays as correlate for blocking activity in the field. Here we discuss clinical manufacturing and testing of current SSM-VIMT candidates and the latest bio-assay development for clinical evaluation. New testing strategies are discussed that may accelerate the evaluation and application of SSM-VIMT. Copyright © 2015. Published by Elsevier Ltd.

  16. Exercise Testing Reveals Everyday Physical Challenges of Bariatric Surgery Candidates.

    Science.gov (United States)

    Creel, David B; Schuh, Leslie M; Newton, Robert L; Stote, Joseph J; Cacucci, Brenda M

    2017-12-01

    Few studies have quantified cardiorespiratory fitness among individuals seeking bariatric surgery. Treadmill testing allows researchers to determine exercise capacity through metabolic equivalents. These findings can assist clinicians in understanding patients' capabilities to carry out various activities of daily living. The purpose of this study was to determine exercise tolerance and the variables associated with fitness, among individuals seeking bariatric surgery. Bariatric surgery candidates completed submaximal treadmill testing and provided ratings of perceived exertion. Each participant also completed questionnaires related to history of exercise, mood, and perceived barriers/benefits of exercise. Over half of participants reported that exercise was "hard to very hard" before reaching 70% of heart rate reserve, and one-third of participants reported that exercise was "moderately hard" at less than 3 metabolic equivalents (light activity). Body mass index and age accounted for the majority of the variance in exercise tolerance, but athletic history, employment status, and perceived health benefits also contributed. Perceived benefit scores were higher than barrier scores. Categories commonly used to describe moderate-intensity exercise (3-6 metabolic equivalents) do not coincide with perceptions of intensity among many bariatric surgery candidates, especially those with a body mass index of 50 or more.

  17. Astrophysical dark matter: candidates from particle physics and detection possibilities

    International Nuclear Information System (INIS)

    Freese, K.

    1989-01-01

    In this talk, I will discuss the arguments that 50% to 90% of the matter in galaxies, including our own, is made of an unknown type of dark matter. I will review the reason why cosmologists believe Ω = 1 and illustrate the contrast with the limits on the amount of baryonic matter from element abundances in Big Bang Nucleosynthesis. Other arguments for nonbaryonic dark matter will also be discussed. Candidates for the dark matter from particle physics will be presented. I will focus on cold dark matter candidates known as WIMPs, weakly interacting massive (O(GeV)) particles. I will try to illustrate why these particles are interesting for astrophysics and outline ideas for cornering them. Detection possibilities for these particles include indirect detection, which takes advantage of the annihilation products of these particles in the galactic halo, the sun, or the earth. Direct detection via newly proposed cryogenic detectors must be sensitive to <∼ keV energy deposits. Annual modulation of the dark matter signal can be used as a signature for these halo particles. I hope to motivate the interest in these particles and discuss ideas for finding them

  18. In silico identification of vaccine candidates against Klebsiella oxytoca.

    Science.gov (United States)

    Talukdar, Sandipan; Bayan, Udeshna; Saikia, Kandarpa Kr

    2017-08-01

    Klebsiella oxytoca causes several diseases in immunocompromised as well as healthy individuals. Increasing resistance to a number of antibiotics makes treatment options limited. Prevention using vaccine could be an important solution to get rid of infections caused by Klebsiella oxytoca. In recent time, genome based approaches have contributed significantly in vaccine development. Our aim was to identify the most conserved and immunogenic antigens that can be considered as potential vaccine candidates. KEGG database was used to find out pathways unique to the bacteria. Subcellular localization of the protein sequences taken from the selected 36 pathways were predicted using PSORTb v3.0.2 and CELLO v2.5. Prediction of B cell epitope and the probability of the antigenicity were evaluated by using IEDB and Vaxijen respectively. BLASTp was done to find out the similarity of the selected proteins with the human proteome. Proteins failing to comply with the set parameters were filtered at each step. Finally, we identified 6 surface exposed proteins as potential vaccine candidates against Klebsiella oxytoca. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Proteomics for discovery of candidate colorectal cancer biomarkers

    Science.gov (United States)

    Álvarez-Chaver, Paula; Otero-Estévez, Olalla; Páez de la Cadena, María; Rodríguez-Berrocal, Francisco J; Martínez-Zorzano, Vicenta S

    2014-01-01

    Colorectal cancer (CRC) is the second most common cause of cancer-related deaths in Europe and other Western countries, mainly due to the lack of well-validated clinically useful biomarkers with enough sensitivity and specificity to detect this disease at early stages. Although it is well known that the pathogenesis of CRC is a progressive accumulation of mutations in multiple genes, much less is known at the proteome level. Therefore, in the last years many proteomic studies have been conducted to find new candidate protein biomarkers for diagnosis, prognosis and as therapeutic targets for this malignancy, as well as to elucidate the molecular mechanisms of colorectal carcinogenesis. An important advantage of the proteomic approaches is the capacity to look for multiple differentially expressed proteins in a single study. This review provides an overview of the recent reports describing the different proteomic tools used for the discovery of new protein markers for CRC such as two-dimensional electrophoresis methods, quantitative mass spectrometry-based techniques or protein microarrays. Additionally, we will also focus on the diverse biological samples used for CRC biomarker discovery such as tissue, serum and faeces, besides cell lines and murine models, discussing their advantages and disadvantages, and summarize the most frequently identified candidate CRC markers. PMID:24744574

  20. CANDIDATE GENE ANALYSIS IN ISRAELI SOLDIERS WITH STRESS FRACTURES

    Directory of Open Access Journals (Sweden)

    Ran Yanovich

    2012-03-01

    Full Text Available To investigate the association of polymorphisms within candidate genes which we hypothesized may contribute to stress fracture predisposition, a case-control, cross- sectional study design was employed. Genotyping 268 Single Nucleotide Polymorphisms- SNPs within 17 genes in 385 Israeli young male and female recruits (182 with and 203 without stress fractures. Twenty-five polymorphisms within 9 genes (NR3C1, ANKH, VDR, ROR2, CALCR, IL6, COL1A2, CBG, and LRP4 showed statistically significant differences (p < 0.05 in the distribution between stress fracture cases and non stress fracture controls. Seventeen genetic variants were associated with an increased stress fracture risk, and eight variants with a decreased stress fracture risk. None of the SNP associations remained significant after correcting for multiple comparisons (false discovery rate- FDR. Our findings suggest that genes may be involved in stress fracture pathogenesis. Specifically, the CALCR and the VDR genes are intriguing candidates. The putative involvement of these genes in stress fracture predisposition requires analysis of more cases and controls and sequencing the relevant genomic regions, in order to define the specific gene mutations