DOE site-specific threat assessment

International Nuclear Information System (INIS)

West, D.J.; Al-Ayat, R.A.; Judd, B.R.

1985-01-01

A facility manager faced with the challenges of protecting a nuclear facility against potential threats must consider the likelihood and consequences of such threats, know the capabilities of the facility safeguards and security systems, and make informed decisions about the cost-effectivness of safeguards and security upgrades. To help meet these challenges, the San Francisco Operations Office of the Department of Energy, in conjunction with the Lawrence Livermore Laboratory, has developed a site-specific threat assessment approach and a quantitative model to improve the quality and consistency of site-specific threat assessment and resultant security upgrade decisions at sensitive Department of Energy facilities. 5 figs

Wilderness Recreation Demand: A Comparison of Travel Cost and On-Site Cost Models

Science.gov (United States)

J.M. Bowker; A. Askew; L. Seymour; J.P. Zhu; D. English; C.M. Starbuck

2009-01-01

This study used travel cost and on-site day cost models, coupled with the Forest Service’s National Visitor Use Monitoring data, to examine the demand for and value of recreation access to designated Wilderness.

Conceptual design of a cover system for the degmay uranium tailings site

Energy Technology Data Exchange (ETDEWEB)

Vatsidin, Saidov; David, S. Kessel; Kim, Chang Lak [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2016-06-15

The Republic of Tajikistan has ten former uranium mining sites. The total volume of all tailings is approximately 55 million tonnes, and the covered area is more than 200 hectares. The safe management of legacy uranium mining and tailing sites has become an issue of concern. Depending on the performance requirements and site-specific conditions (location in an arid, semiarid or humid region), a cover system for uranium tailings sites could be constructed using several material layers using both natural and man-made materials. The purpose of this study is to find a feasible cost-effective cover system design for the Degmay uranium tailings site which could provide a long period (100 years) of protection. The HELP computer code was used in the evaluation of potential Degmay cover system designs. As a result of this study, a cover system with 70 cm thick percolation layer, 30 cm thick drainage layer, geomembrane liner and 60 cm thick barrier soil layer is recommended because it minimizes cover thickness and would be the most cost-effective design.

Photovoltaic balance-of-system designs and costs at PVUSA

Science.gov (United States)

Reyes, A. B.; Jennings, C.

1995-05-01

This report is one in a series of 1994-1995 PVUSA reports that document PVUSA lessons learned at demonstration sites in California and Texas. During the last 7 years (1988 to 1994), 16 PV systems ranging from 20 kW to 500 kW have been installed. Six 20-kW emerging module technology (EMT) arrays and three turnkey (i.e., vendor designed and integrated) utility-scale systems were procured and installed at PVUSA's main test site in Davis, California. PVUSA host utilities have installed a total of seven EMT arrays and utility-scale systems in their service areas. Additional systems at Davis and host utility sites are planned. One of PVUSA's key objectives is to evaluate the performance, reliability, and cost of PV balance-of-system (BOS). In the procurement stage PVUSA encouraged innovative design to improve upon present practice by reducing maintenance, improving reliability, or lowering manufacturing or construction costs. The project team worked closely with suppliers during the design stage not only to ensure designs met functional and safety specifications, but to provide suggestions for improvement. This report, intended for the photovoltaic (PV) industry and for utility project managers and engineers considering PV plant construction and ownership, documents PVUSA utility-scale system design and cost lessons learned. Complementary PVUSA topical reports document: construction and safety experience; five-year assessment of EMTs; validation of the Kerman 500-kW grid-support PV plant benefits; PVUSA instrumentation and data analysis techniques; procurement, acceptance, and rating practices for PV power plants; experience with power conditioning units and power quality.

Assessing cost-effectiveness of specific LID practice designs in response to large storm events

Science.gov (United States)

Chui, Ting Fong May; Liu, Xin; Zhan, Wenting

2016-02-01

Low impact development (LID) practices have become more important in urban stormwater management worldwide. However, most research on design optimization focuses on relatively large scale, and there is very limited information or guideline regarding individual LID practice designs (i.e., optimal depth, width and length). The objective of this study is to identify the optimal design by assessing the hydrological performance and the cost-effectiveness of different designs of LID practices at a household or business scale, and to analyze the sensitivity of the hydrological performance and the cost of the optimal design to different model and design parameters. First, EPA SWMM, automatically controlled by MATLAB, is used to obtain the peak runoff of different designs of three specific LID practices (i.e., green roof, bioretention and porous pavement) under different design storms (i.e., 2 yr and 50 yr design storms of Hong Kong, China and Seattle, U.S.). Then, life cycle cost is estimated for the different designs, and the optimal design, defined as the design with the lowest cost and at least 20% peak runoff reduction, is identified. Finally, sensitivity of the optimal design to the different design parameters is examined. The optimal design of green roof tends to be larger in area but thinner, while the optimal designs of bioretention and porous pavement tend to be smaller in area. To handle larger storms, however, it is more effective to increase the green roof depth, and to increase the area of the bioretention and porous pavement. Porous pavement is the most cost-effective for peak flow reduction, followed by bioretention and then green roof. The cost-effectiveness, measured as the peak runoff reduction/thousand Dollars of LID practices in Hong Kong (e.g., 0.02 L/103 US s, 0.15 L/103 US s and 0.93 L/103 US s for green roof, bioretention and porous pavement for 2 yr storm) is lower than that in Seattle (e.g., 0.03 L/103 US s, 0.29 L/103 US s and 1.58 L/103 US s for

Cost estimate of the Yucca Mountain repository based on the site characterization plan conceptual design: Nevada Nuclear Waste Storage Investigations Project

International Nuclear Information System (INIS)

Gruer, E.R.; Fowler, M.E.; Rocha, G.A.

1987-06-01

This report of the life-cycle costs of a mined repository in tuff is based on the site characterization conceptual design and contains estimates of two methods of waste emplacement - vertical and horizontal. The life cycle of the repository progresses from design and construction to emplacement operations that last 25 years. When emplacement has ended, a caretaker period begins and continues until 50 years from emplacement of the first waste. The life of the repository concludes with closure and decommissioning, which includes backfilling and sealing the repository, decontaminating and razing the surface facilities, restoring the land to as near its original condition as possible, and marking the site. The estimates, developed for each phase of the life cycle of the repository, are based on January 1986 constant (unescalated) dollars and include an allowance for contingency. This report mainly comprises explanations of design and operating assumptions, estimating methods, exclusions, definition of cost accounts, calculating procedures, data sources, staffing and other qualifying remarks. Cost estimates are approximations of value and should not be construed as exact. The cost and staffing detail provided in this estimate is commensurate with the detail in the conceptual design

Drainage filter technologies to mitigate site-specific phosphorus losses

DEFF Research Database (Denmark)

Kjærgaard, Charlotte; Heckrath, Goswin Johann; Iversen, Bo Vangsø

2014-01-01

-specific nutrient losses in drainage. The “SUPREME-TECH” project (2010-2015), funded by the Danish Strategic Research Council, aims at providing the scientific basis for developing cost-effective drainage filter technologies to retain P in agricultural drainage waters. The project studies different approaches...... high risks areas of P loss and applying site-specific measures therefore seems a more cost-efficient approach. The Danish Commission for Nature and Agriculture has now called for a shift of paradigm towards targeted mitigation and development of new, cost-efficient technologies to mitigate site......-scale surface-flow constructed wetland. In the former, various natural and industrial P filter substrates have been tested for their ability to reduce inlet P concentrations to below environmental threshold values (

Musite, a tool for global prediction of general and kinase-specific phosphorylation sites.

Science.gov (United States)

Gao, Jianjiong; Thelen, Jay J; Dunker, A Keith; Xu, Dong

2010-12-01

Reversible protein phosphorylation is one of the most pervasive post-translational modifications, regulating diverse cellular processes in various organisms. High throughput experimental studies using mass spectrometry have identified many phosphorylation sites, primarily from eukaryotes. However, the vast majority of phosphorylation sites remain undiscovered, even in well studied systems. Because mass spectrometry-based experimental approaches for identifying phosphorylation events are costly, time-consuming, and biased toward abundant proteins and proteotypic peptides, in silico prediction of phosphorylation sites is potentially a useful alternative strategy for whole proteome annotation. Because of various limitations, current phosphorylation site prediction tools were not well designed for comprehensive assessment of proteomes. Here, we present a novel software tool, Musite, specifically designed for large scale predictions of both general and kinase-specific phosphorylation sites. We collected phosphoproteomics data in multiple organisms from several reliable sources and used them to train prediction models by a comprehensive machine-learning approach that integrates local sequence similarities to known phosphorylation sites, protein disorder scores, and amino acid frequencies. Application of Musite on several proteomes yielded tens of thousands of phosphorylation site predictions at a high stringency level. Cross-validation tests show that Musite achieves some improvement over existing tools in predicting general phosphorylation sites, and it is at least comparable with those for predicting kinase-specific phosphorylation sites. In Musite V1.0, we have trained general prediction models for six organisms and kinase-specific prediction models for 13 kinases or kinase families. Although the current pretrained models were not correlated with any particular cellular conditions, Musite provides a unique functionality for training customized prediction models

Design and fabrication of a low-cost Darrieus vertical-axis wind-turbine system, phase 2. Volume 3: Design, fabrication, and site drawing

Science.gov (United States)

1983-03-01

The design, fabrication, and site drawings associated with fabrication, installation, and check out of 100 kW 17 meter Vertical Axis Wind Turbines (VAWTs) were reported. The turbines are Darrieus type VAWTs with rotors 17 meters in diameter and 25.15 meters in height. They can produce 100 kW of electric power at a cost of energy as low as 3 cents per kWh, in an 18 mph wind regime using 12% annualized costs. Four turbines are produced, three are installed and operable.

DECISION ANALYSIS OF INCINERATION COSTS IN SUPERFUND SITE REMEDIATION

Science.gov (United States)

This study examines the decision-making process of the remedial design (RD) phase of on-site incineration projects conducted at Superfund sites. Decisions made during RD affect the cost and schedule of remedial action (RA). Decision analysis techniques are used to determine the...

Site-specific issues related to structural/seismic design of an underground independent spent fuel storage installation (ISFSI)

International Nuclear Information System (INIS)

Tripathi, B.P.

2005-01-01

Utilities owning and operating commercial nuclear power plants (NPP) in USA may choose to build an underground Independent Spent Fuel Storage Installation (ISFSI) to store the spent nuclear fuels. The regulatory requirements and other guidance are based on 10 CFR Part 72, Regulatory Guide RG 3.73, Standard Review Plans NUREG-1536 and NUREG-1567, and Interim staff Guidance (ISG) documents as applicable. Structures, Systems, and Components (SSCs) classified as important to safety are designed to withstand the effects of site-specific environmental conditions and natural phenomena such as earthquake, tornado, flood, etc. An underground ISFSI for storage of spent nuclear fuel, presents some unique analysis and design challenges. This paper will briefly address some of these challenges and discuss site-specific loads, including seismic for the ISFSI design. (authors)

Siting, design and cost of shallow land burial facilities in Northern New England. Volume 2. Appendices A-G

International Nuclear Information System (INIS)

1985-05-01

Volume 2 comprises the following Appendices: Existing Environmental Data Base in Maine; Wetland Definition and Classification; Marine Clay; Screening Study; Basal Till Screening Study; Engineering Design Specifications and Costing; New York State Low-Level Radioactive Waste Management; and Maine Yankee's Cost of Low-Level Waste Disposal - 1973-1983

Site-Specific PEGylation of Therapeutic Proteins

Directory of Open Access Journals (Sweden)

Jonathan K. Dozier

2015-10-01

Full Text Available The use of proteins as therapeutics has a long history and is becoming ever more common in modern medicine. While the number of protein-based drugs is growing every year, significant problems still remain with their use. Among these problems are rapid degradation and excretion from patients, thus requiring frequent dosing, which in turn increases the chances for an immunological response as well as increasing the cost of therapy. One of the main strategies to alleviate these problems is to link a polyethylene glycol (PEG group to the protein of interest. This process, called PEGylation, has grown dramatically in recent years resulting in several approved drugs. Installing a single PEG chain at a defined site in a protein is challenging. Recently, there is has been considerable research into various methods for the site-specific PEGylation of proteins. This review seeks to summarize that work and provide background and context for how site-specific PEGylation is performed. After introducing the topic of site-specific PEGylation, recent developments using chemical methods are described. That is followed by a more extensive discussion of bioorthogonal reactions and enzymatic labeling.

Effects of rock riprap design parameters on flood protection costs for uranium tailings impoundments

International Nuclear Information System (INIS)

Ecker, R.M.

1984-07-01

The Pacific Northwest Laboratory (PNL) is studying the problem of long-term protection of earthen covers on decommissioned uranium tailings impoundments. The major erosive forces acting on these covers will be river flooding and overland flow from rainfall-runoff. For impoundments adjacent to rivers, overbank flooding presents the greater potential for significant erosion. To protect the earthen covers against flood erosion, rock riprap armoring will be placed over the cover surface. Because of the large size rock usually required for riprap, the quarrying, transport, and placement of the rock could be a significant part of the decommissioning cost. This report examines the sensitivity of riprap protection costs to certain design parameters at tailings impoundments. The parameters include flood discharge, riprap materials, impoundment side slopes, and an added safety factor. Two decommissioned tailings impoundments are used as case studies for the evaluation. These are the Grand Junction, Colorado, impoundment located adjacent to the Colorado River and the Slickrock, Colorado, impoundment located adjacent to the Dolores River. The evaluation considers only the cost of riprap protection against flood erosion. The study results show that embankment side slope and rock specific gravity can have optimum values or ranges at a specific site. For both case study sites the optimum side slope is about 5H:1V. Of the rock sources considered at Grand Junction, the optimum specific gravity would be about 2.50; however, an optimum rock specific gravity for the Slickrock site could not be determined. Other results indicate that the arbitrary safety factor usually added in riprap design can lead to large increases in protection costs. 22 references, 19 figures, 15 tables

Ringhals Site Study 2013 - An assessment of the decommissioning cost for the Ringhals site

Energy Technology Data Exchange (ETDEWEB)

Hansson, Tommy [Ringhals AB, Ringhals (Sweden); Norberg, Thomas [Solvina AB, Goeteborg (Sweden); Knutsson, Andreas; Fors, Patrik; Sandebert, Camilla [Vattenfall AB, Stockholm (Sweden)

2013-03-15

This report presents the decommissioning cost for the Ringhals site as of 2013. The objective has been to make a best estimate of the costs within the uncertainties of a budgetary estimate. To achieve this, the decommissioning costs have been assessed with support from TLG Services Inc., utilizing their knowledge and experience from U.S. decommissioning projects incorporated in their cost estimation platform DECCER. The 2013 estimate has included the development of a Ringhals-specific cost estimation method that allows for successive improvement in the future. In-house experiences have been included and the method is based on the present decommissioning strategy according to Ringhals decommissioning plan. Two basic approaches have been used in the cost assessment; a bottom up approach to develop unit cost factors (UCF) for recurrent work; and a specific analogy approach for cost estimating special items. The basic, activity-dependent, costs have been complemented by period-dependent costs, derived, among other things, from SKB's newly developed reference planning and organizational model for a Swedish decommissioning project. Furthermore, collateral costs based on the experiences of Barsebaeck have been included. As a final point, all costs have been adjusted for industrial standard contingencies, as suggested by TLG, to achieve a best estimate. In order to make the cost intelligible a comprehensive description of the assumptions, boundary conditions and general basis of the estimate is included in this report. All costs have been reported both according to the International Structure for Decommissioning Costing (ISDC) of Nuclear Installations published by OECD/NEA and according to the SKB developed EEF structure. Furthermore, common costs have been isolated to a theoretical unit 0 to make the cost for respective unit even more comparable on a national and international scale. The calculations show that the total cost for the decommissioning of the Ringhals

Ringhals Site Study 2013 - An assessment of the decommissioning cost for the Ringhals site

International Nuclear Information System (INIS)

Hansson, Tommy; Norberg, Thomas; Knutsson, Andreas; Fors, Patrik; Sandebert, Camilla

2013-03-01

This report presents the decommissioning cost for the Ringhals site as of 2013. The objective has been to make a best estimate of the costs within the uncertainties of a budgetary estimate. To achieve this, the decommissioning costs have been assessed with support from TLG Services Inc., utilizing their knowledge and experience from U.S. decommissioning projects incorporated in their cost estimation platform DECCER. The 2013 estimate has included the development of a Ringhals-specific cost estimation method that allows for successive improvement in the future. In-house experiences have been included and the method is based on the present decommissioning strategy according to Ringhals decommissioning plan. Two basic approaches have been used in the cost assessment; a bottom up approach to develop unit cost factors (UCF) for recurrent work; and a specific analogy approach for cost estimating special items. The basic, activity-dependent, costs have been complemented by period-dependent costs, derived, among other things, from SKB's newly developed reference planning and organizational model for a Swedish decommissioning project. Furthermore, collateral costs based on the experiences of Barsebaeck have been included. As a final point, all costs have been adjusted for industrial standard contingencies, as suggested by TLG, to achieve a best estimate. In order to make the cost intelligible a comprehensive description of the assumptions, boundary conditions and general basis of the estimate is included in this report. All costs have been reported both according to the International Structure for Decommissioning Costing (ISDC) of Nuclear Installations published by OECD/NEA and according to the SKB developed EEF structure. Furthermore, common costs have been isolated to a theoretical unit 0 to make the cost for respective unit even more comparable on a national and international scale. The calculations show that the total cost for the decommissioning of the Ringhals site is

Decision support for the definition of wind turbine systems adequacy to site specificities and weak electrical networks

International Nuclear Information System (INIS)

Arbaoui, A.

2006-10-01

A decision support system for the definition of wind turbine systems is developed by taking into account the wind and site characteristics, the wind turbine components and the electrical network properties close to the site. The approach is based on functional analysis, on the investigation of the functional fluxes and on the definition of a model suitable for supporting decision at the preliminary stages of wind turbine design. The complete set of solutions derived from the model is determined using a Constraint Satisfaction Problem solver. The intrinsic capability of the model to support decision is derived from the investigation of the model parsimony, precision, exactness and specialization. The model takes into account performance criteria resulting from knowledge of manufacturers, distributors and investors. These criteria are used to discriminate design alternatives. Design alternatives correspond to choices of site (wind, electric network) and wind turbine architectures (related to 7 design variables). Performance criteria are the cost of electric kWh, the amount of energy being produced and the discounted total cost of the project. Electric network connection to wind turbines is taken into account through slow variations of the voltage and Flickers phenomenon. First, the maximal rate of penetration of the wind turbine energy production is determined. Next, two design alternatives have been investigated to improve wind turbine system integration in electric distribution networks. These alternatives are a reactive power control system and an inertial energy storage system. Inertial storage systems seem to be more expensive than reactive power control systems for this type of application. The influence of site specificities on decision making process has been established through three different sites (a Mediterranean site and two sites located in northern Europe). Profits relative to the cost of kWh appear to be high for Mediterranean sites. Most of the

The ITER reduced cost design

International Nuclear Information System (INIS)

Aymar, R.

2000-01-01

Six years of joint work under the international thermonuclear experimental reactor (ITER) EDA agreement yielded a mature design for ITER which met the objectives set for it (ITER final design report (FDR)), together with a corpus of scientific and technological data, large/full scale models or prototypes of key components/systems and progress in understanding which both validated the specific design and are generally applicable to a next step, reactor-oriented tokamak on the road to the development of fusion as an energy source. In response to requests from the parties to explore the scope for addressing ITER's programmatic objective at reduced cost, the study of options for cost reduction has been the main feature of ITER work since summer 1998, using the advances in physics and technology databases, understandings, and tools arising out of the ITER collaboration to date. A joint concept improvement task force drawn from the joint central team and home teams has overseen and co-ordinated studies of the key issues in physics and technology which control the possibility of reducing the overall investment and simultaneously achieving the required objectives. The aim of this task force is to achieve common understandings of these issues and their consequences so as to inform and to influence the best cost-benefit choice, which will attract consensus between the ITER partners. A report to be submitted to the parties by the end of 1999 will present key elements of a specific design of minimum capital investment, with a target cost saving of about 50% the cost of the ITER FDR design, and a restricted number of design variants. Outline conclusions from the work of the task force are presented in terms of physics, operations, and design of the main tokamak systems. Possible implications for the way forward are discussed

Drainage filter technologies to mitigate site-specific phosphorus losses in agricultural drainage discharge

DEFF Research Database (Denmark)

Kjærgaard, Charlotte; Heckrath, Goswin Johann; Canga, Eriona

in drainage. The Danish “SUPREME-TECH” project (2010-2016) (www.supreme-tech.dk) aims at providing the scientific basis for developing cost-effective filter technologies for P in agricultural drainage waters. The project studies different approaches of implementing filter technologies including drainage well....... Targeting high risk areas of P loss and applying site-specific measures promises to be a cost-efficient approach. The Danish Commission for Nature and Agriculture has, therefore, now called for a paradigm shift towards targeted, cost-efficient technologies to mitigate site-specific nutrient losses...... environmental threshold values (

Adaptation of the ITER facility design to a Canadian site

International Nuclear Information System (INIS)

Smith, S.

2001-01-01

This paper presents the status of Canadian efforts to adapt the newly revised ITER facility design to suit the specific characteristics of the proposed Canadian site located in Clarington, west of Toronto, Ontario. ITER Canada formed a site-specific design team in 1999, comprising participants from three Canadian consulting companies to undertake this work. The technical aspects of this design activity includes: construction planning, geotechnical investigations, plant layout, heat sink design, electrical system interface, site-specific modifications and tie-ins, seismic design, and radwaste management. These areas are each addressed in this paper. (author)

Spatiotemporally Representative and Cost-Efficient Sampling Design for Validation Activities in Wanglang Experimental Site

Directory of Open Access Journals (Sweden)

Gaofei Yin

2017-11-01

Full Text Available Spatiotemporally representative Elementary Sampling Units (ESUs are required for capturing the temporal variations in surface spatial heterogeneity through field measurements. Since inaccessibility often coexists with heterogeneity, a cost-efficient sampling design is mandatory. We proposed a sampling strategy to generate spatiotemporally representative and cost-efficient ESUs based on the conditioned Latin hypercube sampling scheme. The proposed strategy was constrained by multi-temporal Normalized Difference Vegetation Index (NDVI imagery, and the ESUs were limited within a sampling feasible region established based on accessibility criteria. A novel criterion based on the Overlapping Area (OA between the NDVI frequency distribution histogram from the sampled ESUs and that from the entire study area was used to assess the sampling efficiency. A case study in Wanglang National Nature Reserve in China showed that the proposed strategy improves the spatiotemporally representativeness of sampling (mean annual OA = 74.7% compared to the single-temporally constrained (OA = 68.7% and the random sampling (OA = 63.1% strategies. The introduction of the feasible region constraint significantly reduces in-situ labour-intensive characterization necessities at expenses of about 9% loss in the spatiotemporal representativeness of the sampling. Our study will support the validation activities in Wanglang experimental site providing a benchmark for locating the nodes of automatic observation systems (e.g., LAINet which need a spatially distributed and temporally fixed sampling design.

Intruder scenarios for site-specific waste classification

International Nuclear Information System (INIS)

Kennedy, W.E. Jr.

1988-01-01

The US Department of Energy (DOE) is currently revising its low-level radioactive waste (LLW) management requirements and guidelines for waste generated at its facilities that support defense missions. Specifically, draft DOE 5820.2A, Chapter 3, describes the purpose, policy, and requirements necessary for the management of defense LLW. The draft DOE policy calls for DOE LLW operations to be managed to protect the health and safety of the public, preserve the environment, and ensure that no remedial action will be necessary after termination of operations. The requirements and guidelines apply to radioactive wastes but are also intended to apply to mixed hazardous and radioactive wastes as defined in draft DOE 5400.5, Hazardous and Radioactive Mixed Waste. The basic approach used by DOE is to establish overall performance objectives in terms of ground-water protection and public radiation dose limits and to require site-specific performance assessments to determine compliance. As a result of these performance assessments, each site shall develop waste acceptance criteria that define the allowable quantities and concentrations of specific radioisotopes. Additional limitations on waste disposal design, waste form, and waste treatment shall also be developed on a site-specific basis. As a key step in the site-specific performance assessments, an evaluation must be conducted of potential radiation doses to intruders who may inadvertently move onto a closed DOE LLW disposal site after loss of institutional controls must be conducted. This paper describes the types of intruder scenarios that should be considered when performing this step of the site-specific performance assessment

Definitive design status of the SP-100 Ground Engineering System Test Site

International Nuclear Information System (INIS)

Renkey, E.J. Jr.; Bazinet, G.D.; Bitten, E.J.; Brackenbury, P.J.; Carlson, W.F.; Irwin, J.J.; Edwards, P.A.; Shen, E.J.; Titzler, P.A.

1989-05-01

The SP-100 reactor will be ground tested at the SP-100 Ground Engineering System (GES) Test Site on the US Department of Energy (DOE) Hanford Site near Richland, Washington. Project direction and the flight system design evolution have resulted in a smaller reactor size and the consequential revision to Test Site features to accommodate the design changes and reduce Test Site costs. The significant design events since the completion of the Conceptual Design are discussed in this paper

Definitive design status of the SP-100 Ground Engineering System Test Site

Energy Technology Data Exchange (ETDEWEB)

Renkey, E.J. Jr.; Bazinet, G.D.; Bitten, E.J.; Brackenbury, P.J.; Carlson, W.F.; Irwin, J.J.; Edwards, P.A.; Shen, E.J.; Titzler, P.A.

1989-05-01

The SP-100 reactor will be ground tested at the SP-100 Ground Engineering System (GES) Test Site on the US Department of Energy (DOE) Hanford Site near Richland, Washington. Project direction and the flight system design evolution have resulted in a smaller reactor size and the consequential revision to Test Site features to accommodate the design changes and reduce Test Site costs. The significant design events since the completion of the Conceptual Design are discussed in this paper.

Application of Korean Specific Data to Economic Cost Estimation by KOSCA-MACCS2

International Nuclear Information System (INIS)

Choi, Sun Yeong; Jang, Seung-Cheol

2015-01-01

Default values for various data provided by MACCS2(MELCOR Accident Consequence Code System Version 2) such as population, weather, food, and economic cost are far from current domestic condition. In the case of economic cost data, related default values came from MACCS and WASH-1400. KAERI (Korea Atomic Energy Research Institute) has been developed a Korean-specific level 3 PSA (Probabilistic Safety Assessment) code package based on MACCS2 to reflect domestic condition for off-site consequence analysis. To this end, we performed a study on the domestic specific technical issues for level 3 PSA, which are a dose conversion factor, food chain model, atmospheric dispersion model, and domestic-specific economic effect model. Based on the study, we developed a level 3 PSA code, so-called KOSCAMACCS2 (Korean-specific Off-Site Consequence Analysis based on MACCS2). The purpose of this paper is to introduce economic cost variable provided by KOSCA-MACCS2 and application of Korean-specific data to the related economic cost estimation with KOSCA-MACCS2. In this paper, we introduced economic cost variable provided by KOSCA-MACCS2 and suggested the application plan of Korean-specific data to the related economic cost estimation. To this end, we considered data sources for those economic cost variables to reflect Korea-specific features such as data by Statistics Korea or Bank of Korea etc. For the decontamination related variables, we applied foreign literatures to apply data, which are Extern-E and UNESCO Chernobyl Forum data. Based on the data resources we estimated data for input variables related to economic cost estimation

Application of Korean Specific Data to Economic Cost Estimation by KOSCA-MACCS2

Energy Technology Data Exchange (ETDEWEB)

Choi, Sun Yeong; Jang, Seung-Cheol [KAERI, Daejeon (Korea, Republic of)

2015-05-15

Default values for various data provided by MACCS2(MELCOR Accident Consequence Code System Version 2) such as population, weather, food, and economic cost are far from current domestic condition. In the case of economic cost data, related default values came from MACCS and WASH-1400. KAERI (Korea Atomic Energy Research Institute) has been developed a Korean-specific level 3 PSA (Probabilistic Safety Assessment) code package based on MACCS2 to reflect domestic condition for off-site consequence analysis. To this end, we performed a study on the domestic specific technical issues for level 3 PSA, which are a dose conversion factor, food chain model, atmospheric dispersion model, and domestic-specific economic effect model. Based on the study, we developed a level 3 PSA code, so-called KOSCAMACCS2 (Korean-specific Off-Site Consequence Analysis based on MACCS2). The purpose of this paper is to introduce economic cost variable provided by KOSCA-MACCS2 and application of Korean-specific data to the related economic cost estimation with KOSCA-MACCS2. In this paper, we introduced economic cost variable provided by KOSCA-MACCS2 and suggested the application plan of Korean-specific data to the related economic cost estimation. To this end, we considered data sources for those economic cost variables to reflect Korea-specific features such as data by Statistics Korea or Bank of Korea etc. For the decontamination related variables, we applied foreign literatures to apply data, which are Extern-E and UNESCO Chernobyl Forum data. Based on the data resources we estimated data for input variables related to economic cost estimation.

Progress on building design and site layout, and preparation for procurement

International Nuclear Information System (INIS)

Haange, R.

2004-01-01

The ITER site layout and buildings retain many of the major features worked out for the original 1998 design of ITER. By mid-2001, the design had been adjusted to take account of the reductions in size of the tokamak and in the performance and capability of its supporting plant systems, with a view to providing a building construction cost reduction near the target of 50%. The present status of the site layout and buildings is that, with the exception of the hot cell building, designs are available for the ITER buildings and site layout, in different degrees of detail, ready for final review as soon as the drawings and 3D models have been updated. The ITER site layout is determined by the functions of the various plant systems provided in support of the ITER tokamak. These systems are located in different buildings on the ITER site. Changes in the plant layout inside buildings can, therefore, have an important impact on the overall site layout. The general layout of the site assumes electrical power comes in from the west, heat rejection is on the east, access into the main building for assembly is from the south, and removal of waste is from the north. These orientations are purely notional, determining only the relative positions. Both the European and Japanese potential ITER sites will most likely use seismic isolation of the main tokamak complex. As a result, the detailed design of these buildings and in particular the piping connections to them developed for the 'generic' ITER site will require redesign. Also, the footprint of the main tokamak complex will increase, and hence the layout of the utility tunnel network will have to be updated. A draft Site Facilities Procurement Specification has been written by the International Team. This will require considerable specific input when the site has been selected. Furthermore, the present site layout will have to be reviewed in detail. The generic site has been kept compact. Once a site is available, it may be

Designer's unified cost model

Science.gov (United States)

Freeman, William T.; Ilcewicz, L. B.; Swanson, G. D.; Gutowski, T.

1992-01-01

A conceptual and preliminary designers' cost prediction model has been initiated. The model will provide a technically sound method for evaluating the relative cost of different composite structural designs, fabrication processes, and assembly methods that can be compared to equivalent metallic parts or assemblies. The feasibility of developing cost prediction software in a modular form for interfacing with state of the art preliminary design tools and computer aided design programs is being evaluated. The goal of this task is to establish theoretical cost functions that relate geometric design features to summed material cost and labor content in terms of process mechanics and physics. The output of the designers' present analytical tools will be input for the designers' cost prediction model to provide the designer with a data base and deterministic cost methodology that allows one to trade and synthesize designs with both cost and weight as objective functions for optimization. The approach, goals, plans, and progress is presented for development of COSTADE (Cost Optimization Software for Transport Aircraft Design Evaluation).

Optimal Design and Operation of In-Situ Chemical Oxidation Using Stochastic Cost Optimization Toolkit

Science.gov (United States)

Kim, U.; Parker, J.; Borden, R. C.

2014-12-01

In-situ chemical oxidation (ISCO) has been applied at many dense non-aqueous phase liquid (DNAPL) contaminated sites. A stirred reactor-type model was developed that considers DNAPL dissolution using a field-scale mass transfer function, instantaneous reaction of oxidant with aqueous and adsorbed contaminant and with readily oxidizable natural oxygen demand ("fast NOD"), and second-order kinetic reactions with "slow NOD." DNAPL dissolution enhancement as a function of oxidant concentration and inhibition due to manganese dioxide precipitation during permanganate injection are included in the model. The DNAPL source area is divided into multiple treatment zones with different areas, depths, and contaminant masses based on site characterization data. The performance model is coupled with a cost module that involves a set of unit costs representing specific fixed and operating costs. Monitoring of groundwater and/or soil concentrations in each treatment zone is employed to assess ISCO performance and make real-time decisions on oxidant reinjection or ISCO termination. Key ISCO design variables include the oxidant concentration to be injected, time to begin performance monitoring, groundwater and/or soil contaminant concentrations to trigger reinjection or terminate ISCO, number of monitoring wells or geoprobe locations per treatment zone, number of samples per sampling event and location, and monitoring frequency. Design variables for each treatment zone may be optimized to minimize expected cost over a set of Monte Carlo simulations that consider uncertainty in site parameters. The model is incorporated in the Stochastic Cost Optimization Toolkit (SCOToolkit) program, which couples the ISCO model with a dissolved plume transport model and with modules for other remediation strategies. An example problem is presented that illustrates design tradeoffs required to deal with characterization and monitoring uncertainty. Monitoring soil concentration changes during ISCO

Designers' unified cost model

Science.gov (United States)

Freeman, W.; Ilcewicz, L.; Swanson, G.; Gutowski, T.

1992-01-01

The Structures Technology Program Office (STPO) at NASA LaRC has initiated development of a conceptual and preliminary designers' cost prediction model. The model will provide a technically sound method for evaluating the relative cost of different composite structural designs, fabrication processes, and assembly methods that can be compared to equivalent metallic parts or assemblies. The feasibility of developing cost prediction software in a modular form for interfacing with state-of-the-art preliminary design tools and computer aided design programs is being evaluated. The goal of this task is to establish theoretical cost functions that relate geometric design features to summed material cost and labor content in terms of process mechanics and physics. The output of the designers' present analytical tools will be input for the designers' cost prediction model to provide the designer with a database and deterministic cost methodology that allows one to trade and synthesize designs with both cost and weight as objective functions for optimization. This paper presents the team members, approach, goals, plans, and progress to date for development of COSTADE (Cost Optimization Software for Transport Aircraft Design Evaluation).

Cost-effectiveness of reduction of off-site dose

International Nuclear Information System (INIS)

McGrath, J.J.; Macphee, R.; Arbeau, N.; Miskin, J.; Scott, C.K.; Winters, E.

1988-03-01

Since the early 1970's, nuclear power plants have been designed and operated with a target of not releasing more than one percent of the licensed limits (derived emission limits) in liquid and gaseous effluents. The AECB initiated this study of the cost-effectiveness of the reduction of off-site doses as part of a review to determine if further measures to reduce off-site doses might be reasonably achievable. Atlantic Nuclear has estimated the cost of existing technology options that can be applied for a further reduction of radioactive effluents from future CANDU nuclear power plants. Detritiation, filtration, ion exchange and evaporation are included in the assessment. The costs are presented in 1987 Canadian dollars, and include capital and operating costs for a reference 50 year plant life. Darlington NGS and Point Lepreau NGS are the reference nuclear power plant types and locations. The effect resulting from the hypothetical application of each technology has been calculated as the resulting reduction in world collective radiation dose detriment. The CSA N288.1 procedure was used for local pathway analysis and the global dispersion model developed by the NEA (OECD) group of experts was used for dose calculations. The reduction in the 'collective effective dose equivalent commitment' was assumed to exist for 10,000 years, the expected life-span of solid waste repositories. No attempt was made to model world population dynamics. The collective dose reductions were calculated for a nominal world population of 10 billion persons. The estimated cost and effect of applying the technology options are summarized in a tabular form for input to further consideration of 'reasonably achievable off-site dose levels'

System cost model user's manual, version 1.2

International Nuclear Information System (INIS)

Shropshire, D.

1995-06-01

The System Cost Model (SCM) was developed by Lockheed Martin Idaho Technologies in Idaho Falls, Idaho and MK-Environmental Services in San Francisco, California to support the Baseline Environmental Management Report sensitivity analysis for the U.S. Department of Energy (DOE). The SCM serves the needs of the entire DOE complex for treatment, storage, and disposal (TSD) of mixed low-level, low-level, and transuranic waste. The model can be used to evaluate total complex costs based on various configuration options or to evaluate site-specific options. The site-specific cost estimates are based on generic assumptions such as waste loads and densities, treatment processing schemes, existing facilities capacities and functions, storage and disposal requirements, schedules, and cost factors. The SCM allows customization of the data for detailed site-specific estimates. There are approximately forty TSD module designs that have been further customized to account for design differences for nonalpha, alpha, remote-handled, and transuranic wastes. The SCM generates cost profiles based on the model default parameters or customized user-defined input and also generates costs for transporting waste from generators to TSD sites

Off-site consequences of radiological accidents: methods, costs and schedules for decontamination

International Nuclear Information System (INIS)

Tawil, J.J.; Bold, F.C.; Harrer, B.J.; Currie, J.W.

1985-08-01

This report documents a data base and a computer program for conducting a decontamination analysis of a large, radiologically contaminated area. The data base, which was compiled largely through interviews with knowledgeable persons both in the public and private sectors, consists of the costs, physical inputs, rates and contaminant removal efficiencies of a large number of decontamination procedures. The computer program utilizes this data base along with information specific to the contaminated site to provide detailed information that includes the least costly method for effectively decontaminating each surface at the site, various types of property losses associated with the contamination, the time at which each subarea within the site should be decontaminated to minimize these property losses, the quantity of various types of labor and equipment necessary to complete the decontamination, dose to radiation workers, the costs for surveying and monitoring activities, and the disposal costs associated with radiological waste generated during cleanup. The program and data base are demonstrated with a decontamination analysis of a hypothetical site. 39 refs., 24 figs., 155 tabs

Off-site consequences of radiological accidents: methods, costs and schedules for decontamination

Energy Technology Data Exchange (ETDEWEB)

Tawil, J.J.; Bold, F.C.; Harrer, B.J.; Currie, J.W.

1985-08-01

This report documents a data base and a computer program for conducting a decontamination analysis of a large, radiologically contaminated area. The data base, which was compiled largely through interviews with knowledgeable persons both in the public and private sectors, consists of the costs, physical inputs, rates and contaminant removal efficiencies of a large number of decontamination procedures. The computer program utilizes this data base along with information specific to the contaminated site to provide detailed information that includes the least costly method for effectively decontaminating each surface at the site, various types of property losses associated with the contamination, the time at which each subarea within the site should be decontaminated to minimize these property losses, the quantity of various types of labor and equipment necessary to complete the decontamination, dose to radiation workers, the costs for surveying and monitoring activities, and the disposal costs associated with radiological waste generated during cleanup. The program and data base are demonstrated with a decontamination analysis of a hypothetical site. 39 refs., 24 figs., 155 tabs.

Cost estimate of high-level radioactive waste containers for the Yucca Mountain Site Characterization Project

Energy Technology Data Exchange (ETDEWEB)

Russell, E.W.; Clarke, W. [Lawrence Livermore National Lab., CA (United States); Domian, H.A. [Babcock and Wilcox Co., Lynchburg, VA (United States); Madson, A.A. [Kaiser Engineers California Corp., Oakland, CA (United States)

1991-08-01

This report summarizes the bottoms-up cost estimates for fabrication of high-level radioactive waste disposal containers based on the Site Characterization Plan Conceptual Design (SCP-CD). These estimates were acquired by Babcock and Wilcox (B&S) under sub-contract to Lawrence Livermore National Laboratory (LLNL) for the Yucca Mountain Site Characterization Project (YMP). The estimates were obtained for two leading container candidate materials (Alloy 825 and CDA 715), and from other three vendors who were selected from a list of twenty solicited. Three types of container designs were analyzed that represent containers for spent fuel, and for vitrified high-level waste (HLW). The container internal structures were assumed to be AISI-304 stainless steel in all cases, with an annual production rate of 750 containers. Subjective techniques were used for estimating QA/QC costs based on vendor experience and the specifications derived for the LLNL-YMP Quality Assurance program. In addition, an independent QA/QC analysis is reported which was prepared by Kasier Engineering. Based on the cost estimates developed, LLNL recommends that values of $825K and $62K be used for the 1991 TSLCC for the spent fuel and HLW containers, respectively. These numbers represent the most conservative among the three vendors, and are for the high-nickel anstenitic steel (Alloy 825). 6 refs., 7 figs.

Cost estimate of high-level radioactive waste containers for the Yucca Mountain Site Characterization Project

International Nuclear Information System (INIS)

Russell, E.W.; Clarke, W.; Domian, H.A.; Madson, A.A.

1991-08-01

This report summarizes the bottoms-up cost estimates for fabrication of high-level radioactive waste disposal containers based on the Site Characterization Plan Conceptual Design (SCP-CD). These estimates were acquired by Babcock and Wilcox (B ampersand S) under sub-contract to Lawrence Livermore National Laboratory (LLNL) for the Yucca Mountain Site Characterization Project (YMP). The estimates were obtained for two leading container candidate materials (Alloy 825 and CDA 715), and from other three vendors who were selected from a list of twenty solicited. Three types of container designs were analyzed that represent containers for spent fuel, and for vitrified high-level waste (HLW). The container internal structures were assumed to be AISI-304 stainless steel in all cases, with an annual production rate of 750 containers. Subjective techniques were used for estimating QA/QC costs based on vendor experience and the specifications derived for the LLNL-YMP Quality Assurance program. In addition, an independent QA/QC analysis is reported which was prepared by Kasier Engineering. Based on the cost estimates developed, LLNL recommends that values of $825K and $62K be used for the 1991 TSLCC for the spent fuel and HLW containers, respectively. These numbers represent the most conservative among the three vendors, and are for the high-nickel anstenitic steel (Alloy 825). 6 refs., 7 figs

Design principle of TVO's final repository and preliminary adaptation to site specific conditions

International Nuclear Information System (INIS)

Salo, J-P.; Reikkola, R.

1995-01-01

Teollisuuden Voima Oy (TVO) is responsible for the management of spent fuel produced by the Olkiluoto power plant. TVO's current programme of spent fuel management is based on the guidelines and time schedule set by the Finnish Government. TVO has studied a final disposal concept in which the spent fuel bundles are encapsulated in copper canisters and emplaced in Finnish bedrock. According to the plan the final repository for spent fuel will be in operation by 2020. TVO's updated technical plans for the disposal of spent fuel together with a performance analysis (TVO-92) were submitted to the authorities in 1992. The paper describes the design principle of TVO's final repository and preliminary adaptation of the repository to site specific conditions. (author). 10 refs., 5 figs

Gas recombination device design and cost study. Final report

Energy Technology Data Exchange (ETDEWEB)

1980-07-01

Under a contract with Argonne National Laboratory, VARTA Batterie AG. conducted a design and cost study of hydrogen-oxygen recombination devices (HORD) for use with utility load-leveling lead-acid cells. Design specifications for the devices, through extensive calculation of the heat-flow conditions of the unit, were developed. Catalyst and condenser surface areas were specified. The exact dimensions can, however, be adjusted to the cell dimension and the space available above the cell. Design specifications were also developed for additional components required to ensure proper function of the recombination device, including metal hydride compound decomposer, aerosol retainer, and gas storage component. Costs for HORD were estimated to range from $4 to $10/kWh cell capacity for the production of a large number of units (greater than or equal to 10,000 units). The cost is a function of cell size and positive grid design. 21 figures, 2 tables.

Technical basis for the ITER-FEAT outline design. Progress in resolving open design issues from the outline design report

International Nuclear Information System (INIS)

2000-01-01

In this publication the technical basis for the ITER-FEAT outline design is presented. It comprises the Plant Design Specifications, the Safety Principles and Environmental Criteria, the Site Requirements and Site Design Assumptions. The outline of the key features of the ITER-FEAT design includes main physical parameters and assessment, design overview and preliminary safety assessment, cost and schedule

Decision support for the definition of wind turbine systems adequacy to site specificities and weak electrical networks; Aide a la decision pour la definition d'un systeme eolien, adequation au site et a un reseau faible

Energy Technology Data Exchange (ETDEWEB)

Arbaoui, A

2006-10-15

A decision support system for the definition of wind turbine systems is developed by taking into account the wind and site characteristics, the wind turbine components and the electrical network properties close to the site. The approach is based on functional analysis, on the investigation of the functional fluxes and on the definition of a model suitable for supporting decision at the preliminary stages of wind turbine design. The complete set of solutions derived from the model is determined using a Constraint Satisfaction Problem solver. The intrinsic capability of the model to support decision is derived from the investigation of the model parsimony, precision, exactness and specialization. The model takes into account performance criteria resulting from knowledge of manufacturers, distributors and investors. These criteria are used to discriminate design alternatives. Design alternatives correspond to choices of site (wind, electric network) and wind turbine architectures (related to 7 design variables). Performance criteria are the cost of electric kWh, the amount of energy being produced and the discounted total cost of the project. Electric network connection to wind turbines is taken into account through slow variations of the voltage and Flickers phenomenon. First, the maximal rate of penetration of the wind turbine energy production is determined. Next, two design alternatives have been investigated to improve wind turbine system integration in electric distribution networks. These alternatives are a reactive power control system and an inertial energy storage system. Inertial storage systems seem to be more expensive than reactive power control systems for this type of application. The influence of site specificities on decision making process has been established through three different sites (a Mediterranean site and two sites located in northern Europe). Profits relative to the cost of kWh appear to be high for Mediterranean sites. Most of the

Nanoparticles for Site Specific Genome Editing

Science.gov (United States)

McNeer, Nicole Ali

Triplex-forming peptide nucleic acids (PNAs) can be used to coordinate the recombination of short 50-60 by "donor DNA" fragments into genomic DNA, resulting in site-specific correction of genetic mutations or the introduction of advantageous genetic modifications. Site-specific gene editing in hematopoietic stem and progenitor cells (HSPCs) could result in treatment or cure of inherited disorders of the blood such as beta-thalassemia. Gene editing in HSPCs and differentiated T cells could help combat HIV/AIDs by modifying receptors, such as CCR5, necessary for R5-tropic HIV entry. However, translation of genome modification technologies to clinical practice is limited by challenges in intracellular delivery, especially in difficult-to-transfect hematolymphoid cells. In vivo gene editing could also provide novel treatment for systemic monogenic disorders such as cystic fibrosis, an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane receptor. Here, we have engineered biodegradable nanoparticles to deliver oligonucleotides for site-specific genome editing of disease-relevant genes in human cells, with high efficiency, low toxicity, and editing of clinically relevant cell types. We designed nanoparticles to edit the human beta-globin and CCR5 genes in hematopoietic cells. We show that poly(lactic-co-glycolic acid) (PLGA) nanoparticles can delivery PNA and donor DNA for site-specific gene modification in human hematopoietic cells in vitro and in vivo in NOD-scid IL2rgammanull mice. Nanoparticles delivered by tail vein localized to hematopoietic compartments in the spleen and bone marrow of humanized mice, resulting in modification of the beta-globin and CCR5 genes. Modification frequencies ranged from 0.005 to 20% of cells depending on the organ and cell type, without detectable toxicity. This project developed highly versatile methods for delivery of therapeutics to hematolymphoid cells and hematopoietic stem cells, and will help to

Hanford Site environmental management specification

Energy Technology Data Exchange (ETDEWEB)

Grygiel, M.L.

1998-06-10

The US Department of Energy, Richland Operations Office (RL) uses this Hanford Site Environmental Management Specification (Specification) to document top-level mission requirements and planning assumptions for the prime contractors involved in Hanford Site cleanup and infrastructure activities under the responsibility of the US Department of Energy, Office of Environmental Management. This Specification describes at a top level the activities, facilities, and infrastructure necessary to accomplish the cleanup of the Hanford Site and assigns this scope to Site contractors and their respective projects. This Specification also references the key National Environmental Policy Act of 1969 (NEPA), Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), and safety documentation necessary to accurately describe the cleanup at a summary level. The information contained in this document reflects RL`s application of values, priorities, and critical success factors expressed by those involved with and affected by the Hanford Site project. The prime contractors and their projects develop complete baselines and work plans to implement this Specification. These lower-level documents and the data that support them, together with this Specification, represent the full set of requirements applicable to the contractors and their projects. Figure 1-1 shows the relationship of this Specification to the other basic Site documents. Similarly, the documents, orders, and laws referenced in this specification represent only the most salient sources of requirements. Current and contractual reference data contain a complete set of source documents.

Hanford Site environmental management specification

International Nuclear Information System (INIS)

Grygiel, M.L.

1998-01-01

The US Department of Energy, Richland Operations Office (RL) uses this Hanford Site Environmental Management Specification (Specification) to document top-level mission requirements and planning assumptions for the prime contractors involved in Hanford Site cleanup and infrastructure activities under the responsibility of the US Department of Energy, Office of Environmental Management. This Specification describes at a top level the activities, facilities, and infrastructure necessary to accomplish the cleanup of the Hanford Site and assigns this scope to Site contractors and their respective projects. This Specification also references the key National Environmental Policy Act of 1969 (NEPA), Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), and safety documentation necessary to accurately describe the cleanup at a summary level. The information contained in this document reflects RL's application of values, priorities, and critical success factors expressed by those involved with and affected by the Hanford Site project. The prime contractors and their projects develop complete baselines and work plans to implement this Specification. These lower-level documents and the data that support them, together with this Specification, represent the full set of requirements applicable to the contractors and their projects. Figure 1-1 shows the relationship of this Specification to the other basic Site documents. Similarly, the documents, orders, and laws referenced in this specification represent only the most salient sources of requirements. Current and contractual reference data contain a complete set of source documents

Design cost scoping studies. Nevada Test Site Terminal Waste Storage Program, Subtask 1.3: facility hardening studies

International Nuclear Information System (INIS)

Yanev, P.I.; Owen, G.N.

1978-04-01

As part of a program being conducted by the U.S. Department of Energy, Nevada Operations Office, to determine the feasibility of establishing a terminal waste storage repository at the Nevada Test Site, URS/John A. Blume and Associates, Engineers, made approximate determinations of the additional costs required to provide protection of structures against seismic forces. A preliminary estimate is presented of the added costs required to harden the surface structures, underground tunnels and storage rooms, and vertical shafts of the repository against ground motion caused by earthquakes and underground nuclear explosions (UNEs). The conceptual design of all of the structures was adapted from proposed bedded-salt waste-isolation repositories. Added costs for hardening were calculated for repositories in three candidate geological materials (Eleana argillite, Climax Stock granite, and Jackass Flats tuff) for several assumed peak ground accelerations caused by earthquakes (0.3g, 0.5g, and 0.7g) and by UNEs (0.5g, 0.7g, and 1.0g). Hardening procedures to protect the tunnels, storage rooms, and shafts against incremental seismic loadings were developed from (1) qualitative considerations of analytically determined seismic stresses and (2) engineering evaluations of the dynamic response of the rock mass and the tunnel support systems. The added costs for seismic hardening of the surface structures were found to be less than 1% of the estimated construction cost of the surface structures. For the underground structures, essentially no hardening was required for peak ground accelerations up to 0.3g; however, added costs became significant at 0.5g, with a possible increase in structural costs for the underground facilities of as much as 35% at 1.0g

Site-Specific Innovation

DEFF Research Database (Denmark)

Reeh, Henrik; Hemmersam, Peter

2015-01-01

Currently, cities across the Northern European region are actively redeveloping their former industrial harbours. Indeed, harbours areas are essential in the long-term transition from industrial to information and experience societies; harbours are becoming sites for new businesses and residences...... question is how innovation may contribute to urban life and site-specific qualities....

Specific Space Transportation Costs to GEO - Past, Present and Future

Science.gov (United States)

Koelle, Dietrich E.

2002-01-01

The largest share of space missions is going to the Geosynchronous Orbit (GEO); they have the highest commercial importance. The paper first shows the historic trend of specific transportation costs to GEO from 1963 to 2002. It started out with more than 500 000 /kg(2002-value) and has come down to 36 000 /kg. This reduction looks impressive, however, the reason is NOT improved technology or new techniques but solely the growth of GEO payloads`unit mass. The first GEO satellite in 1963 did have a mass of 36 kg mass (BoL) . This has grown to a weight of 1600 kg (average of all GEO satellites) in the year 2000. Mass in GEO after injection is used here instead of GTO mass since the GTO mass depends on the launch site latitude. The specific cost reduction is only due to the "law-of-scale", valid in the whole transportation business: the larger the payload, the lower the specific transportation cost. The paper shows the actual prices of launch services to GTO by the major launch vehicles. Finally the potential GEO transportation costs of future launch systems are evaluated. What is the potential reduction of specific transportation costs if reusable elements are introduced in future systems ? Examples show that cost reductions up to 75 % seem achievable - compared to actual costs - but only with launch systems optimized according to modern principles of cost engineering. 1. 53rd International Astronautical Congress, World Space Congress Houston 2. First Submission 3. Specific Space Transportation Costs to GEO - Past, Present and Future 4. KOELLE, D.E. 5. IAA.1.1 Launch Vehicles' Cost Engineering and Economic Competitiveness 6. D.E. Koelle; A.E. Goldstein 7. One overhead projector and screen 8. Word file attached 9. KOELLE I have approval to attend the Congress. I am not willing to present this paper at the IAC Public Outreach Program.

SU-E-T-760: Tolerance Design for Site-Specific Range in Proton Patient QA Process Using the Six Sigma Model

International Nuclear Information System (INIS)

Lah, J; Shin, D; Kim, G

2015-01-01

Purpose: To show how tolerance design and tolerancing approaches can be used to predict and improve the site-specific range in patient QA process in implementing the Six Sigma. Methods: In this study, patient QA plans were selected according to 6 site-treatment groups: head &neck (94 cases), spine (76 cases), lung (89 cases), liver (53 cases), pancreas (55 cases), and prostate (121 cases), treated between 2007 and 2013. We evaluated a model of the Six Sigma that determines allowable deviations in design parameters and process variables in patient-specific QA, where possible, tolerance may be loosened, then customized if it necessary to meet the functional requirements. A Six Sigma problem-solving methodology is known as DMAIC phases, which are used stand for: Define a problem or improvement opportunity, Measure process performance, Analyze the process to determine the root causes of poor performance, Improve the process by fixing root causes, Control the improved process to hold the gains. Results: The process capability for patient-specific range QA is 0.65 with only ±1 mm of tolerance criteria. Our results suggested the tolerance level of ±2–3 mm for prostate and liver cases and ±5 mm for lung cases. We found that customized tolerance between calculated and measured range reduce that patient QA plan failure and almost all sites had failure rates less than 1%. The average QA time also improved from 2 hr to less than 1 hr for all including planning and converting process, depth-dose measurement and evaluation. Conclusion: The objective of tolerance design is to achieve optimization beyond that obtained through QA process improvement and statistical analysis function detailing to implement a Six Sigma capable design

SU-E-T-760: Tolerance Design for Site-Specific Range in Proton Patient QA Process Using the Six Sigma Model

Energy Technology Data Exchange (ETDEWEB)

Lah, J [Myongji Hospital, Goyang, Gyeonggi-do (Korea, Republic of); Shin, D [National Cancer Center, Goyang-si, Gyeonggi-do (Korea, Republic of); Kim, G [University of California, San Diego, La Jolla, CA (United States)

2015-06-15

Purpose: To show how tolerance design and tolerancing approaches can be used to predict and improve the site-specific range in patient QA process in implementing the Six Sigma. Methods: In this study, patient QA plans were selected according to 6 site-treatment groups: head &neck (94 cases), spine (76 cases), lung (89 cases), liver (53 cases), pancreas (55 cases), and prostate (121 cases), treated between 2007 and 2013. We evaluated a model of the Six Sigma that determines allowable deviations in design parameters and process variables in patient-specific QA, where possible, tolerance may be loosened, then customized if it necessary to meet the functional requirements. A Six Sigma problem-solving methodology is known as DMAIC phases, which are used stand for: Define a problem or improvement opportunity, Measure process performance, Analyze the process to determine the root causes of poor performance, Improve the process by fixing root causes, Control the improved process to hold the gains. Results: The process capability for patient-specific range QA is 0.65 with only ±1 mm of tolerance criteria. Our results suggested the tolerance level of ±2–3 mm for prostate and liver cases and ±5 mm for lung cases. We found that customized tolerance between calculated and measured range reduce that patient QA plan failure and almost all sites had failure rates less than 1%. The average QA time also improved from 2 hr to less than 1 hr for all including planning and converting process, depth-dose measurement and evaluation. Conclusion: The objective of tolerance design is to achieve optimization beyond that obtained through QA process improvement and statistical analysis function detailing to implement a Six Sigma capable design.

Decision support for the definition of wind turbine systems adequacy to site specificities and weak electrical networks; Aide a la decision pour la definition d'un systeme eolien, adequation au site et a un reseau faible

Energy Technology Data Exchange (ETDEWEB)

Arbaoui, A

2006-10-15

A decision support system for the definition of wind turbine systems is developed by taking into account the wind and site characteristics, the wind turbine components and the electrical network properties close to the site. The approach is based on functional analysis, on the investigation of the functional fluxes and on the definition of a model suitable for supporting decision at the preliminary stages of wind turbine design. The complete set of solutions derived from the model is determined using a Constraint Satisfaction Problem solver. The intrinsic capability of the model to support decision is derived from the investigation of the model parsimony, precision, exactness and specialization. The model takes into account performance criteria resulting from knowledge of manufacturers, distributors and investors. These criteria are used to discriminate design alternatives. Design alternatives correspond to choices of site (wind, electric network) and wind turbine architectures (related to 7 design variables). Performance criteria are the cost of electric kWh, the amount of energy being produced and the discounted total cost of the project. Electric network connection to wind turbines is taken into account through slow variations of the voltage and Flickers phenomenon. First, the maximal rate of penetration of the wind turbine energy production is determined. Next, two design alternatives have been investigated to improve wind turbine system integration in electric distribution networks. These alternatives are a reactive power control system and an inertial energy storage system. Inertial storage systems seem to be more expensive than reactive power control systems for this type of application. The influence of site specificities on decision making process has been established through three different sites (a Mediterranean site and two sites located in northern Europe). Profits relative to the cost of kWh appear to be high for Mediterranean sites. Most of the

Proposed Site-Specific Response Spectra for Surabaya-Madura Bridge

Directory of Open Access Journals (Sweden)

Dyah Kusumastuti

2008-01-01

Full Text Available This paper presents a site-specific seismic hazard study to determine the recommended seismic design criteria for Suramadu Bridge. The study is performed using probabilistic seismic hazard approach to determine maximum acceleration and response spectra at bedrock and followed by local site effect analysis to determine maximum acceleration and response spectra at ground surface. The probabilistic seismic hazard analysis (PSHA is carried out using 3-dimension (3-D seismic source models (fault source model. Two hazard levels are analysed to represent 150 and 3,300 years return period of ground motion around site location. The local site effect analysis is performed using 1-dimension (1-D shear wave propagation theory to obtain peak ground acceleration and response spectra at ground surface. Finally, the site-specific surface response spectra with 5 percent damping are developed based on the mean plus one standard deviation concept from the result of local site effect analysis.

Assessment of Wind Turbine for Site-Specific Conditions using Probabilistic Methods

DEFF Research Database (Denmark)

Heras, Enrique Gómez de las; Gutiérrez, Roberto; Azagra, Elena

2013-01-01

turbines, helping to the decision making during the site assessment phase of wind farm designs. First, the design equation for the failure mode of interest is defined, where the loads associated to the site-specific wind conditions are compared with the design limits of the structural component. A limit...... be very dependent on the site. The uncertainties on the wind properties depend on issues like the available wind data, the quality of the measurement sensors, the type of terrain or the accuracy of the engineering models for horizontal and vertical spatial extrapolation. An example is included showing two...

Site specific information in site selection

International Nuclear Information System (INIS)

Aeikaes, T.; Hautojaervi, A.

1998-01-01

The programme for the siting of a deep repository for final disposal of spent nuclear fuel was started already in 1983 and is carried out today by Posiva Oy which continues the work started by Teollisuuden Voima Oy. The programme aims at site selection by the end of the year 2000. The programme has progressed in successive interim stages with defined goals. After an early phase for site identification, five sites were selected in 1987 for preliminary site characterisation. Three of these were selected and judged to be best suited for the more detailed characterisation in 1992. An additional new site was included into the programme based on a separate feasibility study in the beginning of 1997. Since the year 1983 several safety assessments together with technical plans of the facility have been completed. When approaching the site selection the needs for more detailed consideration of the site specific properties in the safety assessment have been increased. The Finnish regulator STUK has published a proposal for general safety requirements for the final disposal of spent nuclear fuel in Finland. This set of requirements has been projected to be used in conjunction of the decision making by the end 2000. Based on the site evaluation all sites can provide a stable environment and there is evidence that the requirements for the longevity of the canister can be fulfilled at each site. In this manner the four candidate sites do not differ too much from each other. The main difference between the sites is in the salinity of the deep groundwater. The significance of differences in the salinity for the long-term safety cannot be defined yet. The differences may contribute to the discussion of the longevity of the bentonite buffer and also to the modelling of the groundwater flow and transport. The use of the geosphere as a transport barrier is basically culminated on the questions about sparse but fast flow routes and 'how bad channeling can be'. To answer these questions

Expedited Site Characterization: A rapid, cost-effective process for preremedial site characterization

International Nuclear Information System (INIS)

Burton, J.C.; Walker, J.L.; Jennings, T.V.; Aggarwal, P.K.; Hastings, B.; Meyer, W.T.; Rose, C.M.; Rosignolo, C.L.

1993-01-01

Argonne National Laboratory has developed a unique, cost- and time-effective, technically innovative process for preremedial site characterization, referred to as Expedited Site Characterization (ESC). The cost of the ESC field sampling process ranges from 1/10 to 1/5 of the cost of traditional site characterization. The time required for this ESC field activity is approximately 1/30 of that for current methods. Argonne's preremedial site investigations based on this approach have been accepted by the appropriate regulatory agencies. The ESC process is flexible and neither site nor contaminant dependent. The process has been successfully tested and applied in site investigations of multiple contaminated landfills in New Mexico (for the US Department of the Interior's Bureau of Land Management [BLM]) and at former grain storage facilities in Nebraska and Kansas, contaminated with carbon tetrachloride (for the Department of Agriculture's Commodity Credit Corporation [CCC/USDA]). A working demonstration of this process was sponsored by the US Department of Energy (DOE) Office of Technology Development as a model of the methodology needed to accelerate site characterizations at DOE facilities. This report describes the application of the process in New Mexico, Nebraska and Kansas

Development of the NUMO pre-selection, site-specific safety case

International Nuclear Information System (INIS)

Fujiyama, Tetsuo; Suzuki, Satoru; Deguchi, Akira; Umeki, Hiroyuki

2016-01-01

Key conclusions: ◆ “The NUMO pre-selection, site-specific safety case” provides the basic structure for subsequent safety cases that will be applied to any selected site, emphasising practical approaches and methodology which will be applicable for the conditions/constraints during an actual siting process. ◆ The preliminary results of the design and safety assessment would underpin the feasibility and safety of geological disposal in Japan.

Cost estimation of a specifically designed direct light processing (DLP) additive manufacturing machine for precision printing

DEFF Research Database (Denmark)

Charalambis, Alessandro; Davoudinejad, Ali; Tosello, Guido

2017-01-01

creating new opportunities for manufacturers in a variety of industrial sectors. AM is an essentialprototyping technique for product design and development that is used in many different fields. However, the suitability of AMapplications in actual production in an industrial context needs to be determined......Additive Manufacturing (AM) refers to a portfolio of novel manufacturing technologies based on a layer-by-layer fabrication method.The market and industrial application of additive manufacturing technologies as an established manufacturing process have increasedexponentially in the last years....... This study, presents a cost estimation model forprecision printing with a specifically designed Digital Light Processing (DLP) AM machine built and validated at the Technical Universityof Denmark. The model presented in this study can be easily adapted and applied to estimate within a high level...

Recent wet storage solutions and costs at NPS sites in Finland

International Nuclear Information System (INIS)

Salo, J.P.; Tormala, V.P.

1987-01-01

In Finland the power companies have chosen the wet storing method when building the two recent interim spent fuel stores at Olkiluoto and Loviisa NPS sites. These decisions were based on extensive comparison studies of different storing methods and designs. TVO's and IVO's stores started operation F Y 1987 and 1984. One of them was built as an away-from-reactor on the NPS site, the other one as an at-reactor-store, wall-to-wall to the NPS process building. The capacity of the Olkiluoto store will be enough for all the spent fuel arising from the 30 years operation of units TVO I and TVO II, 1270-1400 tHM. The stores are unmanned. The vital process systems of both stores and doubled. The project timetables were kept very well. The investment costs were considerably less than generally mentioned in literature, in spite of the severe climatic conditions of the store sites. The costs of the stores added up to 40 and 50 USD/kgU in 1986 currency, without construction time interest costs. The actual operating and maintenance costs of the Loviisa store have been very low during the first three years of operation. It has been estimated that the operating costs of the independent TVO-KPA-STORE will be less than 1.3 million USD/a

Site-specific weed control technologies

DEFF Research Database (Denmark)

Christensen, Svend; Søgaard, Henning Tangen; Kudsk, Per

2009-01-01

Site-specific weed control technologies are defined as machinery or equipment embedded with technologies that detect weeds growing in a crop and, taking into account predefined factors such as economics, takes action to maximise the chances of successfully controlling them. In the article, we...... describe the basic parts of site specific weed control technologies, comprising of weed sensing systems, weed management models and precision weed control implements. A review of state-of-the-art technologies shows that several weed sensing systems and precision implements have been developed over the last...... of knowledge about the economic and environmental potential for increasing the resolution of weed control. The integration of site-specific information on weed distribution, weed species composition and density, and the effect on crop yield, is decisive for successful site-specific weed management.   Keywords...

Top-down and bottom-up approaches for cost estimating new reactor designs

International Nuclear Information System (INIS)

Berbey, P.; Gautier, G.M.; Duflo, D.; Rouyer, J.L.

2007-01-01

For several years, Generation-4 designs will be 'pre-conceptual' for the less mature concepts and 'preliminary' for the more mature concepts. In this situation, appropriate data for some of the plant systems may be lacking to develop a bottom-up cost estimate. Therefore, a more global approach, the Top-Down Approach (TDA), is needed to help the designers and decision makers in comparing design options. It utilizes more or less simple models for cost estimating the different parts of a design. TDA cost estimating effort applies to a whole functional element whose cost is approached by similar estimations coming from existing data, ratios and models, for a given range of variation of parameters. Modeling is used when direct analogy is not possible. There are two types of models, global and specific ones. Global models are applied to cost modules related to Code Of Account. Exponential formulae such as Ci = Ai + (Bi x Pi n ) are used when there are cost data for comparable modules in nuclear or other industries. Specific cost models are developed for major specific components of the plant: - process equipment such as reactor vessel, steam generators or large heat exchangers. - buildings, with formulae estimating the construction cost from base cost of m3 of building volume. - systems, when unit costs, cost ratios and models are used, depending on the level of detail of the design. Bottom Up Approach (BUA), which is based on unit prices coming from similar equipment or from manufacturer consulting, is very valuable and gives better cost estimations than TDA when it can be applied, that is at a rather late stage of the design. Both approaches are complementary when some parts of the design are detailed enough to be estimated by BUA, and when BUA results are used to check TDA results and to improve TDA models. This methodology is applied to the HTR (High Temperature Reactor) concept and to an advanced PWR design

Design and integration of components for site specific control of fertilizer application

NARCIS (Netherlands)

Bergeijk, van J.

2001-01-01

Keywords: Precision Agriculture, Site Specific Agriculture, Global Positioning System, GPS, Fertilizer Application, Information System.

Spatial and temporal variability in soil, crop and climate characteristics results in non optimal use of fertilizers when the application

On Decommissioning Costs of the Ranstad Site

Energy Technology Data Exchange (ETDEWEB)

Varley, Geoff (NAC International (United Kingdom))

2010-08-15

The main objective of this study has been to extend the review of the future cost to decommission and dismantling the industrial area at the site of the old uranium mine at Ranstad in Sweden. The feedback of experience and actual costs from a decommissioning project in the United Kingdom (A26 in Springfields) has been used to help in the assessment of the reasonableness of the estimated costs for decommissioning of the old uranium mine in Ranstad. A quantitative (albeit subjective) statement about the accuracy of the Ranstad cost estimate has been developed. Also, the factors relevant to the allocation of costs between the Swedish state and the current owners of the old uranium mine site have been evaluated and presented. The study has developed the following main conclusions: - The importance of thorough characterization/radiological mapping to the selection of the optimum decommissioning approach (technique) has been reinforced very strongly. - Thorough characterization has the related consequence of being able to better define the costs of decommissioning, in terms of equipment needed, labour hours required and, importantly, the volumes of different categories of waste requiring different routes (and associated different unit costs) for ultimate disposition. - Uncertainties in the Ranstad decommissioning cost estimate nevertheless remain, in particular relating to the viability of the proposed approach to dismantling and decontaminating the acid proof bricks that line the pools in the Large Leaching Hall; a method that is acknowledged to be not proven. The outcome could have an impact on actual dismantling and decontamination costs, as well as on the costs of ultimate waste disposition. The KB2010 cost estimate report does not offer an alternative in the event that the base plan proves to be unfeasible. - On balance it would appear that the continued presence of RMA at the Ranstad site ultimately will provide a net cost benefit to the program. The extra costs

On Decommissioning Costs of the Ranstad Site

International Nuclear Information System (INIS)

Varley, Geoff

2010-08-01

The main objective of this study has been to extend the review of the future cost to decommission and dismantling the industrial area at the site of the old uranium mine at Ranstad in Sweden. The feedback of experience and actual costs from a decommissioning project in the United Kingdom (A26 in Springfields) has been used to help in the assessment of the reasonableness of the estimated costs for decommissioning of the old uranium mine in Ranstad. A quantitative (albeit subjective) statement about the accuracy of the Ranstad cost estimate has been developed. Also, the factors relevant to the allocation of costs between the Swedish state and the current owners of the old uranium mine site have been evaluated and presented. The study has developed the following main conclusions: - The importance of thorough characterization/radiological mapping to the selection of the optimum decommissioning approach (technique) has been reinforced very strongly. - Thorough characterization has the related consequence of being able to better define the costs of decommissioning, in terms of equipment needed, labour hours required and, importantly, the volumes of different categories of waste requiring different routes (and associated different unit costs) for ultimate disposition. - Uncertainties in the Ranstad decommissioning cost estimate nevertheless remain, in particular relating to the viability of the proposed approach to dismantling and decontaminating the acid proof bricks that line the pools in the Large Leaching Hall; a method that is acknowledged to be not proven. The outcome could have an impact on actual dismantling and decontamination costs, as well as on the costs of ultimate waste disposition. The KB2010 cost estimate report does not offer an alternative in the event that the base plan proves to be unfeasible. - On balance it would appear that the continued presence of RMA at the Ranstad site ultimately will provide a net cost benefit to the program. The extra costs

A study of feasibility, design and cost of excavations for underground siting of nuclear power plants

International Nuclear Information System (INIS)

1976-02-01

A study conducted for the State Power Board on underground siting of nuclear power plants is presented. The report is divided into two chapters, both concerning the technical aspects of large underground openings. The first chapter gives a brief general survey of the problems involved, and the second outlines the technical aspects of a PWR project at a specific site. Details are given in 8 appendices and arrangement drawings. The project differs from conventional hydroelectric excavation schemes mainly in the fact that the spherical reactor containment requires a vault of 60m free span, and the turbine hall a cylindrical vault of 45m span, both of which exceed any span hitherto built for similar purposes. This requires a comparatively wide extrapolation of tested and available experience in underground excavations for permanent civil use. To what extent and under what circumstances such extrapolation is tenable must be tested in practice, preferably in a specially controlled prototype test. However the study indicates that conventional nuclear power plants can be sited underground when the topography and rock conditions are suitable. A 1000-2000 MW conventional plant adapted for underground siting will require large span caverns, tunnels and shafts, totalling about 1.0 mill. cubic metres of underground excavation. In addition access and cooling water tunnels, depending on the location, will require 0.2-0.5 mill. cubic metres of tunnel excavations. The excavations and support work can be completed within a construction time of about 2 1/2 years at an estimated total cost of 215 mill. Norwegian kroner (1975 value). (JIW)

Supercollider: Design changes

International Nuclear Information System (INIS)

Anon.

1990-01-01

A major task faced by the new US Superconducting Supercollider (SSC) Laboratory as it began life early last year was to prepare a baseline design, cost and schedule for the site in Ellis County, Texas. The conceptual design developed by the SSC Central Design Group at Berkeley in 1986 was for a generic site, and served as the basis of the cost estimate submitted to Congress for fiscal year 1990. Under the terms of the contract between Universities Research Association (URA - the SSC parent organization) and the US Department of Energy to establish the SSC Laboratory, signed in January 1989, a report on the SiteSpecific Conceptual Design Report was complete by December

Supercollider: Design changes

Energy Technology Data Exchange (ETDEWEB)

Anon.

1990-04-15

A major task faced by the new US Superconducting Supercollider (SSC) Laboratory as it began life early last year was to prepare a baseline design, cost and schedule for the site in Ellis County, Texas. The conceptual design developed by the SSC Central Design Group at Berkeley in 1986 was for a generic site, and served as the basis of the cost estimate submitted to Congress for fiscal year 1990. Under the terms of the contract between Universities Research Association (URA - the SSC parent organization) and the US Department of Energy to establish the SSC Laboratory, signed in January 1989, a report on the SiteSpecific Conceptual Design Report was complete by December.

Site layout and balance of plant design for an accelerator-driven materials processing complex

Energy Technology Data Exchange (ETDEWEB)

Cunliffe, J.; Taussig, R.; Ghose, S. [Bechtel Corporation, San Francisco, CA (United States)] [and others

1995-10-01

High energy proton beam accelerators are under consideration for use in radioisotope production, surplus weapons material destruction, radioactive waste transmutation, and thorium-based energy conversion cycles. While there are unique aspects to each of these applications that must be accommodated in the design of the associated facility, all share a set of fundamental characteristics that in large measure dictate the site layout features and many balance-of-plant (BOP) design requirements found to be common to all. This paper defines these key design determinants and goes on to discuss the manner in which they have been accommodated in the pre-conceptual design for a particular materials production application. An estimate of the costs associated with this BOP design is also presented with the aim of guiding future evaluations where the basic plant designs are similar to that of this specific case.

Estimating the demand for drop-off recycling sites: a random utility travel cost approach.

Science.gov (United States)

Sidique, Shaufique F; Lupi, Frank; Joshi, Satish V

2013-09-30

Drop-off recycling is one of the most widely adopted recycling programs in the United States. Despite its wide implementation, relatively little literature addresses the demand for drop-off recycling. This study examines the demand for drop-off recycling sites as a function of travel costs and various site characteristics using the random utility model (RUM). The findings of this study indicate that increased travel costs significantly reduce the frequency of visits to drop-off sites implying that the usage pattern of a site is influenced by its location relative to where people live. This study also demonstrates that site specific characteristics such as hours of operation, the number of recyclables accepted, acceptance of commingled recyclables, and acceptance of yard-waste affect the frequency of visits to drop-off sites. Copyright © 2013 Elsevier Ltd. All rights reserved.

Site characterization design and techniques used at the Southern Shipbuilding Corporation site

International Nuclear Information System (INIS)

Mueller, J.P.; Geraghty, C.A.; Moore, G.W.; Mullins, J.R.

1995-01-01

The Southern Shipbuilding Corporation (SSC) site is an inactive barge/ship manufacturing and repair facility situated on approximately 54 acres in Slidell, St. Tammany Parish, Louisiana. Two unlined surface impoundments (North and South impoundments) are situated on the northwest portion of the site and are surrounded on three sides by Bayou Bonfouca. These impoundments are the sources of carcinogenic polynuclear aromatic hydrocarbon (CPAH) contamination at the site. Inadequate containment has resulted in the release of impoundment wastes into the bayou. To evaluate potential response alternatives for the site, an Engineering Evaluation/Cost Analysis (EE/CA) field investigation was conducted from July through October 1994. A two phase sampling approach was used in combination with innovative and traditional sampling techniques, field screening technologies, and exploitation of the visual characteristics of the waste to determine the extent of waste migration with limited off-site laboratory confirmation. A skid-mounted mobile drilling unit, secured to a specialized sampling platform designed for multiple applications, was used for collection of sediment cores from the bayou as well as tarry sludge cores from the impoundments. Field screening of core samples was accomplished on site using an organic vapor analyzer and a total petroleum hydrocarbon (TPH) field analyzer. Pollutants of concern include metals, cyanide, dioxin, and organic compounds. This paper presents details on the sampling design and characterization techniques used to accomplish the EE/CA field investigation

Early Site Permit Demonstration Program: Station design alternatives report

International Nuclear Information System (INIS)

1993-03-01

This report provides the results of investigating the basis for including Station Design Alternatives (SDAs) in the regulatory guidance given for nuclear plant environmental reports (ERs), explains approaches or processes for evaluating SDAs at the early site permit (ESP) stage, and applies one of the processes to each of the ten systems or subsystems considered as SDAS. The key objective o this report s to demonstrate an adequate examination of alternatives can be performed without the extensive development f design data. The report discusses the Composite Suitability Approach and the Established Cutoff Approach in evaluating station design alternatives and selects one of these approaches to evaluate alternatives for each of the plant or station that were considered. Four types of ALWRs have been considered due to the availability of extensive plant data: System 80+, AP600, Advanced Boiling Reactor (ABWR), and Simplified Boiling Water Reactor (SBWR). This report demonstrates the feasibility of evaluating station design alternatives when reactor design detail has not been determined, quantitatively compares the potential ental impacts of alternatives, and focuses the ultimate selection of a alternative on cost and applicant-specific factors. The range of alternatives system is deliberately limited to a reasonable number to demonstrate the or to the three most commonly used at operating plants

Beyond Information Architecture: A Systems Integration Approach to Web-site Design

Directory of Open Access Journals (Sweden)

Krisellen Maloney

2017-09-01

Full Text Available Users' needs and expectations regarding access to information have fundamentally changed, creating a disconnect between how users expect to use a library Web site and how the site was designed. At the same time, library technical infrastructures include legacy systems that were not designedf or the Web environment. The authors propose a framework that combines elements of information architecture with approaches to incremental system design and implementation. The framework allows for the development of a Web site that is responsive to changing user needs, while recognizing the need for libraries to adopt a cost-effective approach to implementation and maintenance.

Minimizing total costs of forest roads with computer-aided design ...

Indian Academy of Sciences (India)

imum total road costs, while conforming to design specifications, environmental ..... quality, and enhancing fish and wildlife habitat, an appropriate design ..... Soil, Water and Timber Management: Forest Engineering Solutions in Response to.

Brownfields Recommendations for Sustainable Site Design — Green Landscape Plan

Science.gov (United States)

The assessment of conditions contained in this report focuses on site-specific environmental and soil conditions that might affect recommendations related to sustainable landscaping and site design, stormwater management, and stormwater reuse.

Development of subcontractor indirect cost and other direct cost at the DOE Fernald Site

International Nuclear Information System (INIS)

Cossman, R.L.

1994-01-01

The Fernald Environmental Restoration Management Corporation (FERMCO) took great strides in the development of cost estimates at Fernald. There have been many opportunities to improve on how the policies and procedures pertaining to cost estimates were to be implemented. As FERMCO took over the existing Fernald facility, the Project Controls Division began to format the estimating procedures and tools to do business at Fernald. The Estimating Department looked at the problems that pre-existed at the site. One of the key problems that FERMCO encountered was how to summarized the direct and indirect accounts of each subcontracted estimate. Direct costs were broken down by prime and sub-prime accounts. This presented a level of detail that had not been experienced at the site before; it also created many issues concerning accounts and definitions to be applied to ''all other accounts associated with a project.'' Existing subcontract indirect cost accounts were reviewed from existing historical estimates. It was found that some were very detailed and some were not. The Estimating Department was given the task of standardizing the accounts and percentages for each of the subcontractor indirect costs. Then, as the project progressed, the percentages could be revised with actual estimates, subcontract comparisons, or with level of effort (LOE) accounts, which would represent qualified people assigned a task for the completion of each project. The approach is to assign particular employees to perform a specific task within a project from start to finish, and then to reassign the individual(s) to a new project (if it was available) integrating the expertise available with the skills required by the other operable units

Designing a Low-Cost Multifunctional Infant Incubator.

Science.gov (United States)

Tran, Kevin; Gibson, Aaron; Wong, Don; Tilahun, Dagmawi; Selock, Nicholas; Good, Theresa; Ram, Geetha; Tolosa, Leah; Tolosa, Michael; Kostov, Yordan; Woo, Hyung Chul; Frizzell, Michael; Fulda, Victor; Gopinath, Ramya; Prasad, J Shashidhara; Sudarshan, Hanumappa; Venkatesan, Arunkumar; Kumar, V Sashi; Shylaja, N; Rao, Govind

2014-06-01

Every year, an unacceptably large number of infant deaths occur in developing nations, with premature birth and asphyxia being two of the leading causes. A well-regulated thermal environment is critical for neonatal survival. Advanced incubators currently exist, but they are far too expensive to meet the needs of developing nations. We are developing a thermodynamically advanced low-cost incubator suitable for operation in a low-resource environment. Our design features three innovations: (1) a disposable baby chamber to reduce infant mortality due to nosocomial infections, (2) a passive cooling mechanism using low-cost heat pipes and evaporative cooling from locally found clay pots, and (3) insulated panels and a thermal bank consisting of water that effectively preserve and store heat. We developed a prototype incubator and visited and presented our design to our partnership hospital site in Mysore, India. After obtaining feedback, we have determined realistic, nontrivial design requirements and constraints in order to develop a new prototype incubator for clinical trials in hospitals in India. © 2014 Society for Laboratory Automation and Screening.

Improving Site-Specific Radiological Performance Assessments - 13431

Energy Technology Data Exchange (ETDEWEB)

Tauxe, John; Black, Paul; Catlett, Kate; Lee, Robert; Perona, Ralph; Stockton, Tom; Sully, Mike [Neptune and Company, Inc., Los Alamos, New Mexico 87544 (United States)

2013-07-01

a Bayesian approach to probabilistic modeling and risk analysis, to guide improvements in PA. This decision-making approach, [4, 5, 6] provides a transparent formal framework for using a value- or objective-focused approach to decision-making. DA, as an analytical means to implement structured decision making, provides a context for both understanding how uncertainty affects decisions and for targeting uncertainty reduction. The proposed DA approach improves defensibility and transparency of decision-making. The DA approach is fully consistent with the need to perform realistic modeling (rather than conservative modeling), including evaluation of site-specific factors. Instead of using generic stylized scenarios for radionuclide fate and transport and for human exposures to radionuclides, site-specific scenarios better represent the advantages and disadvantages of alternative disposal sites or engineered designs, thus clarifying their differences as well as providing a sound basis for evaluation of site performance. The full DA approach to PA is described, from explicitly incorporating societal values through stakeholder involvement to model building. Model building involves scoping by considering features, events, processes, and exposure scenarios (FEPSs), development of a conceptual site model (CSM), translation into numerical models and subsequent computation, and model evaluation. These are implemented in a cycle of uncertainty analysis, sensitivity analysis and value of information analysis so that uncertainty can be reduced until sufficient confidence is gained in the decisions to be made. This includes the traditional focus on hydrogeological processes, but also places emphasis on other FEPSs such as biotically-induced transport and human exposure phenomena. The significance of human exposure scenarios is emphasized by modifying the traditional acronym 'FEPs' to include them, hence 'FEPSs'. The radioactive waste community is also

Improving Site-Specific Radiological Performance Assessments - 13431

International Nuclear Information System (INIS)

Tauxe, John; Black, Paul; Catlett, Kate; Lee, Robert; Perona, Ralph; Stockton, Tom; Sully, Mike

2013-01-01

probabilistic modeling and risk analysis, to guide improvements in PA. This decision-making approach, [4, 5, 6] provides a transparent formal framework for using a value- or objective-focused approach to decision-making. DA, as an analytical means to implement structured decision making, provides a context for both understanding how uncertainty affects decisions and for targeting uncertainty reduction. The proposed DA approach improves defensibility and transparency of decision-making. The DA approach is fully consistent with the need to perform realistic modeling (rather than conservative modeling), including evaluation of site-specific factors. Instead of using generic stylized scenarios for radionuclide fate and transport and for human exposures to radionuclides, site-specific scenarios better represent the advantages and disadvantages of alternative disposal sites or engineered designs, thus clarifying their differences as well as providing a sound basis for evaluation of site performance. The full DA approach to PA is described, from explicitly incorporating societal values through stakeholder involvement to model building. Model building involves scoping by considering features, events, processes, and exposure scenarios (FEPSs), development of a conceptual site model (CSM), translation into numerical models and subsequent computation, and model evaluation. These are implemented in a cycle of uncertainty analysis, sensitivity analysis and value of information analysis so that uncertainty can be reduced until sufficient confidence is gained in the decisions to be made. This includes the traditional focus on hydrogeological processes, but also places emphasis on other FEPSs such as biotically-induced transport and human exposure phenomena. The significance of human exposure scenarios is emphasized by modifying the traditional acronym 'FEPs' to include them, hence 'FEPSs'. The radioactive waste community is also recognizing that disposal sites are to be considered a national

SITE-94. Site specific base data for the performance assessment

International Nuclear Information System (INIS)

Geier, J.; Tiren, S.; Dverstorp, B.; Glynn, P.

1996-06-01

This report documents the site specific base data that were available, and the utilization of these data within SITE-94. A brief summary is given of SKB's preliminary site investigations for the Aespoe Hard Rock Laboratory (HRL), which were the main source of site-specific data for SITE-94, and an overview is given of the field methods and instrumentation for the preliminary investigations. A compilation is given of comments concerning the availability and quality of the data for Aespoe, and specific recommendations are given for future site investigations. It was found that the HRL pre-investigations produced a large quantity of data which were, for the most part, of sufficient quality to be valuable for a performance assessment. However, some problems were encountered regarding documentation, procedural consistency, positional information, and storage of the data from the measurements. 77 refs, 4 tabs

Design of an environmental site assessment template for open radioactive site contamination : a radioecological risk approach and case study

International Nuclear Information System (INIS)

Nguyen, T.

2004-01-01

To reduce redundancy, cost, and time, while at the same time ultimately increasing the effectiveness of the radioactive risk management process, a logical framework incorporating risk assessments (human cancer and environmental risks) into the environmental site assessment process was designed for radioactive open site contamination. Risk-based corrective action is becoming an increasingly more acceptable approach for the remediation of contaminated sites. In the past, cleanup goals were usually established without any regard to the risk involved, by mandating remediation goals based solely on maximum contamination levels. Now, a multi-stage environmental site assessment template has been developed on a radioecological approach. The template gives a framework for making environmentally sound decisions based on relevant regulations and guidelines. The first stage involves the comparison of the background screening activity level to the regulated activity level, the second stage involves the use of site-specific information to determine the risk involved with the contamination, and the third stage provides a remediation decision matrix based on results from the first two stages. This environmental site assessment template is unique because it incorporates the modified Canadian National Classification System for radioactive contaminated sites and two different types of risk assessments (human cancer risks and the newly designed ecological risk) into the decision making process. The template was used to assess a radiologically contaminated site at the Canadian Forces Base at Suffield (Alberta) as a case study, and it reaffirms the Department of National Defence's action as appropriate. This particular site is a Class 3, has an overall insignificant human cancer risk ( -6 ) and a low environmental risk, and conforms to all regulated guidelines. Currently, it is restricted and should be left as is, provided that the subsurface is not disturbed. (author)

Site-specific management of cotton root rot using historical remote sensing imagery

Science.gov (United States)

Cotton root rot can now be effectively controlled with Topguard Terra Fungicide, but site-specific application of the fungicide can greatly reduce treatment cost as only portions of the field are infested with the disease. The overall goal of this three-year project was to demonstrate how to use his...

Conceptual design and cost study for a dual-purpose nuclear-electric reverse osmosis seawater conversion plant

Energy Technology Data Exchange (ETDEWEB)

1979-04-01

The objective of this study was to develop a conceptual design and cost estimate for a 25 million gallon per day seawater reverse osmosis desalting plant operating at both Caribbean and Persian Gulf sites. The plant would operate in conjunction with a 1000 MW(e) nuclear power plant. Four seawater membrane manufacturers were supplied with feedwater analysis and a simplified cost estimating procedure in order to recommend membrane systems which would be applicable. For both sites a two-stage system was selected for development of a conceptual cost estimate. The product water cost was found to be (based upon 1978 United States construction costs) $3.17/1000 gallons for the Caribbean site and $3.75/1000 gallons for the Persian Gulf site.

Conceptual design and cost study for a dual-purpose nuclear-electric reverse osmosis seawater conversion plant

International Nuclear Information System (INIS)

1979-04-01

The objective of this study was to develop a conceptual design and cost estimate for a 25 million gallon per day seawater reverse osmosis desalting plant operating at both Caribbean and Persian Gulf sites. The plant would operate in conjunction with a 1000 MW(e) nuclear power plant. Four seawater membrane manufacturers were supplied with feedwater analysis and a simplified cost estimating procedure in order to recommend membrane systems which would be applicable. For both sites a two-stage system was selected for development of a conceptual cost estimate. The product water cost was found to be (based upon 1978 United States construction costs) $3.17/1000 gallons for the Caribbean site and $3.75/1000 gallons for the Persian Gulf site

Experiments, conceptual design, preliminary cost estimates and schedules for an underground research facility

International Nuclear Information System (INIS)

Korbin, G.; Wollenberg, H.; Wilson, C.; Strisower, B.; Chan, T.; Wedge, D.

1981-09-01

Plans for an underground research facility are presented, incorporating techniques to assess the hydrological and thermomechanical response of a rock mass to the introduction and long-term isolation of radioactive waste, and to assess the effects of excavation on the hydrologic integrity of a repository and its subsequent backfill, plugging, and sealing. The project is designed to utilize existing mine or civil works for access to experimental areas and is estimated to last 8 years at a total cost for contruction and operation of $39.0 million (1981 dollars). Performing the same experiments in an existing underground research facility would reduce the duration to 7-1/2 years and cost $27.7 million as a lower-bound estimate. These preliminary plans and estimates should be revised after specific sites are identified which would accommodate the facility

Design and control strategy for a hybrid green energy system for mobile telecommunication sites

Science.gov (United States)

Okundamiya, Michael S.; Emagbetere, Joy O.; Ogujor, Emmanuel A.

2014-07-01

The rising energy costs and carbon footprint of operating mobile telecommunication sites in the emerging world have increased research interests in green technology. The intermittent nature of most green energy sources creates the problem of designing the optimum configuration for a given location. This study presents the design analysis and control strategy for a cost effective and reliable operation of the hybrid green energy system (HGES) for GSM base transceiver station (BTS) sites in isolated regions. The design constrains the generation and distribution of power to reliably satisfy the energy demand while ensuring safe operation of the system. The overall process control applies the genetic algorithm-based technique for optimal techno-economic sizing of system's components. The process simulation utilized meteorological data for 3 locations (Abuja, Benin City and Sokoto) with varying climatic conditions in Nigeria. Simulation results presented for green GSM BTS sites are discussed and compared with existing approaches.

Site-specific probabilistic seismic hazard analyses for the Idaho National Engineering Laboratory. Volume 1: Final report

International Nuclear Information System (INIS)

1996-05-01

This report describes and summarizes a probabilistic evaluation of ground motions for the Idaho National Engineering Laboratory (INEL). The purpose of this evaluation is to provide a basis for updating the seismic design criteria for the INEL. In this study, site-specific seismic hazard curves were developed for seven facility sites as prescribed by DOE Standards 1022-93 and 1023-96. These sites include the: Advanced Test Reactor (ATR); Argonne National Laboratory West (ANL); Idaho Chemical Processing Plant (ICPP or CPP); Power Burst Facility (PBF); Radioactive Waste Management Complex (RWMC); Naval Reactor Facility (NRF); and Test Area North (TAN). The results, probabilistic peak ground accelerations and uniform hazard spectra, contained in this report are not to be used for purposes of seismic design at INEL. A subsequent study will be performed to translate the results of this probabilistic seismic hazard analysis to site-specific seismic design values for the INEL as per the requirements of DOE Standard 1020-94. These site-specific seismic design values will be incorporated into the INEL Architectural and Engineering Standards

Evaluating the cost of adult voluntary medical male circumcision in a mixed (surgical and PrePex site compared to a hypothetical PrePex-only site in South Africa

Directory of Open Access Journals (Sweden)

Hae-Young Kim

2015-12-01

Full Text Available Background: Several circumcision devices have been evaluated for a safe and simplified male circumcision among adults. The PrePex device was prequalified for voluntary male medical circumcision (VMMC in May 2013 by the World Health Organization and is expected to simplify the procedure safely while reducing cost. South Africa is scaling up VMMC. Objective: To evaluate the overall unit cost of VMMC at a mixed site vs. a hypothetical PrePex-only site in South Africa. Design: We evaluated the overall unit cost of VMMC at a mixed site where PrePex VMMC procedure was added to routine forceps-guided scalpel-based VMMC in Soweto, South Africa. We abstracted costs and then modeled these costs for a hypothetical PrePex-only site, at which 9,600 PrePex circumcisions per year could be done. We examined cost drivers and modeled costs, varying the price of the PrePex device. The healthcare system perspective was used. Results: In both sites, the main contributors of cost were personnel and consumables. If 10% of all VMMC were by PrePex at the mixed site, the overall costs of the surgical method and PrePex were similar – US$59.62 and $59.53, respectively. At the hypothetical PrePex-only site, the unit cost was US$51.10 with PrePex circumcisions having markedly lower personnel and biohazardous waste management costs. In sensitivity analysis with the cost of PrePex kit reduced to US$10 and $2, the cost of VMMC was further reduced. Conclusions: Adding PrePex to an existing site did not necessarily reduce the overall costs of VMMC. However, starting a new PrePex-only site is feasible and may significantly reduce the overall cost by lowering both personnel and capital costs, thus being cost-effective in the long term. Achieving a lower cost for PrePex will be an important contributor to the scale-up of VMMC.

A thick homogeneous vegetated cover design proves cost - and schedule-effective for the reclamation of uranium mills sites near Spokane, Washington

Energy Technology Data Exchange (ETDEWEB)

Blacklaw, J.; Robertson, G.; Stoffel, D.; Ahmad, J.; Fordham, E. [Washington State Dept. of Health, Olympia, WA (United States)] [and others

1997-08-01

The Washington State Department of Health (WDOH) has licensed two medium sized uranium mills with tailings impoundments covering 28 and 40 hectares (70 and 100 acres), respectively, The uranium mill licensees have submitted closure and reclamation plans to the state, and site-specific conditions have determined the closure design features, Conventional uranium mill cover designs usually incorporate an overall cap of one to three meters, which includes a low-permeability clay barrier layer. A technical evaluation of several uranium mill facilities that used this design was published in the fall of 1994 and reported that unexpected vegetation root damage had occurred in the low-permeability clay (or bentonite amended) barrier layers. The technical report suggested that the low-permeability design feature at some sites could be compromised within a very short time and the regulatory goal of 1,000 years performance might not be achieved. In October 1994, WDOH sponsored a technical forum meeting to consider design alternatives to address these reliability concerns. Representatives from the federal government, nuclear industry, licensees, engineering firms, and state regulatory agencies attended the workshop. Risk factors considered in the evaluation of the uranium mill reclamation plans include: (1) radon gas emanation through the cover (the air pathway), and (2) migration of hazardous and/or radioactive constituents (the groundwater pathway). Additional design considerations include site structural stability, longevity of 1,000 years, and no active (ongoing) maintenance. 9 refs.

Practical, cost-effective method for real-time surveillance of widely-separated remote sites

International Nuclear Information System (INIS)

Braley, R.E.; Olson, A.W.; Rufer, R.P.

1979-01-01

Effective intrusion protection for uninhabited sites scattered widely throughout a large geographic area can be a difficult and expensive proposition. When the sites are important enough to require continuous surveillance, the problem is even worse. Roving patrols are not effective, and conventional alarms don't provide enough information to allow a meaningful response. Television systems have possibilities but also disadvantages: the usual system is both costly and inflexible. This paper describes our solution to the problem: a cost effective instrusion protection system used to simultaneously protect many sites scattered over many square miles, with realtime surveillance from a central point. The system is based on a state-of-the-art FM CATV concept that is capable of providing surveillance for multiple sites, is modular in design for quick setup, flexible, and easily maintained. A electronic motion detector is incorporated for each site under surveillance, with a visual and audible alarm to alert the observer at the central control console. The observer can then bring the intruded site up on a large-screen monitor for detailed assessment. The system is relatively economical as all equipment is commercially available and all installation is straight-forward and follows usual CATV construction practices

Structuring a cost-effective site characterization

International Nuclear Information System (INIS)

Berven, B.A.; Little, C.A.; Swaja, R.E.

1990-01-01

Successful chemical and radiological site characterizations are complex activities which require meticulously detailed planning. Each layer of investigation is based upon previously generated information about the site. Baseline historical, physical, geological, and regulatory information is prerequisite for preliminary studies at a site. Preliminary studies then provide samples and measurements which define the identity of potential contaminants and define boundaries around the area to be investigated. The goal of a full site characterization is to accurately determine the extent and magnitude of contaminants and carefully define the site conditions such that the future movements of site contaminants can be assessed for potential exposure to human occupants and/or environmental impacts. Critical to this process is the selection of appropriate measurement and sampling methodology, selection and use of appropriate instrumentation and management/interpretation of site information. Site investigations require optimization between the need of information to maximize the understanding of site conditions and the cost of acquiring that information. 5 refs., 1 tab

Site-specific analysis of the cobbly soils at the Grand Junction processing site

International Nuclear Information System (INIS)

1992-06-01

This report describes a recent site-specific analysis to evaluate the necessity of a recommendation to install a slurry trench around the Grand Junction processing site. The following analysis addresses the cobbly nature of the site's radiologically contaminated foundation soil, reassesses the excavation depths based on bulk radionuclide concentrations, and presents data-based arguments that support the elimination of the initially proposed slurry trench. The slurry trench around the processing site was proposed by the Remedial Action Contractor (RAC) to minimize the amount of water encountered during excavation. The initial depths of excavation developed during conceptual design, which indicated the need for a slurry wall, were reexamined as part of this analysis. This reanalysis, based on bulk concentrations of a cobbly subsoil, supports decreasing the original excavation depth, limiting the dewatering quantities to those which can be dissipated by normal construction activities. This eliminates the need for a slurry trench andseparate water treatment prior to permitted discharge

a Framework for Low-Cost Multi-Platform VR and AR Site Experiences

Science.gov (United States)

Wallgrün, J. O.; Huang, J.; Zhao, J.; Masrur, A.; Oprean, D.; Klippel, A.

2017-11-01

Low-cost consumer-level immersive solutions have the potential to revolutionize education and research in many fields by providing virtual experiences of sites that are either inaccessible, too dangerous, or too expensive to visit, or by augmenting in-situ experiences using augmented and mixed reality methods. We present our approach for creating low-cost multi-platform virtual and augmented reality site experiences of real world places for education and research purposes, making extensive use of Structure-from-Motion methods as well as 360° photography and videography. We discuss several example projects, for the Mayan City of Cahal Pech, Iceland's Thrihnukar volcano, the Santa Marta informal settlement in Rio, and for the Penn State Campus, and we propose a framework for creating and maintaining such applications by combining declarative content specification methods with a central linked-data based spatio-temporal information system.

Design, performance and cost of energy from high concentration and flat-plate utility-scale PV systems

International Nuclear Information System (INIS)

Stolte, W.J.; Whisnant, R.A.; McGowin, C.R.

1993-01-01

This paper presents the results of a recent study to assess the near-term cost of power in central station applications. Three PV technologies were evaluated: Fresnel-lens high-concentration photovoltaic (HCPV), central receiver HCPV, and flat-plate PV using thin-film copper indium diselenide (CIS) cell technology. Baseline assumptions included PV cell designs and performances projected for the 1995 timeframe, 25 and 100 MW/year cell manufacturing rates, 50 MW power plant size, and mature technology cost and performance estimates. The plant design characteristics are highlighted. Potential sites were evaluated and selected for the PV power plants (Carrisa Plains, CA and Apalachicola, FL) and cell manufacturing plants (Dallas-Fort Worth, TX). Conceptual designs and cost estimates were developed for the plants and their components. Plant performance was modeled and the designs were optimized to minimize levelized energy costs. Overall, the flat plate design exhibited the lowest energy costs among the designs evaluated. Its levelized energy costs at the Carrisa Plains site were estimated to be 11.8 and 10.8 cents/kWh (1990 $) for 25 and 100 MW/year module production rates, respectively. This meets the 12 cents/kWh DOE near-term goal. The energy cost of the Fresnel lens plant (at Carrisa Plains and a 100 MW/year cell production rate) was estimated to be 12.4 cents/kWh and the corresponding central receiver energy cost was estimated to be 13.1 cents/kWh, both of which are very close to the DOE goal. Further design optimization efforts are still warranted and can be expected to reduce plant capital costs

Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy

Science.gov (United States)

Katti, Kattesh V.; Prabhu, Kandikere R.; Gali, Hariprasad; Pillarsetty, Nagavara Kishore; Volkert, Wynn A.

2003-10-21

There is provided a method of labeling a biomolecule with a transition metal or radiometal in a site specific manner to produce a diagnostic or therapeutic pharmaceutical compound by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radio metal or a transition metal, and covalently linking the resulting metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. Also provided is a method of synthesizing the --PR.sub.2 containing biomolecules by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radiometal or a transition metal, and covalently linking the resulting radio metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. There is provided a therapeutic or diagnostic agent comprising a --PR.sub.2 containing biomolecule.

Site-specific Seismic Hazard Assessment to Establish Elastic Design Properties for Oman Museum-Across Ages, Manah, Sultante of Oman

Science.gov (United States)

El Hussain, I. W.

2017-12-01

The current study provides a site specific deterministic seismic hazard assessment (DSHA) at the selected site for establishing the Oman Museum-Across Ages at Manah area, as a part of a comprehensive geotechnical and seismological plan to design the facilities accordingly. The DSHA first defines the seismic sources that might influence the site and assesses the maximum possible earthquake magnitude for each of them. By assuming each of these maximum earthquakes to occur at a location placing them at the closest distances to the site, the ground motion is predicted utilizing empirical ground motion prediction equations. The local site effects are performed by determining the fundamental frequency of the soft soil using HVSR technique and by estimating amplification spectra using the soil characteristics (mainly shear-wave velocity). Shear-wave velocity has been evaluated using the MASW technique. The maximum amplification value of 2.1 at spectral period 0.06 sec is observed at the ground surface, while the largest amplification value at the top of the conglomerate layer (at 5m depth) is 1.6 for a spectral period of 0.04 Sec. The maximum median 5% damped peak ground acceleration is found to be 0.263g at a spectral period of 0.1 sec. Keywords: DSHA; Site Effects; HVSR; MASW; PGA; Spectral Period

Project schedule and cost estimate report

International Nuclear Information System (INIS)

1988-03-01

All cost tables represent obligation dollars, at both a constant FY 1987 level and an estimated escalation level, and are based on the FY 1989 DOE Congressional Budget submittal of December 1987. The cost tables display the total UMTRA Project estimated costs, which include both Federal and state funding. The Total Estimated Cost (TEC) for the UMTRA Project is approximately $992.5 million (in 1987 escalated dollars). Project schedules have been developed that provide for Project completion by September 1994, subject to Congressional approval extending DOE's authorization under Public Law 95-604. The report contains site-specific demographic data, conceptual design assumptions, preliminary cost estimates, and site schedules. A general project overview is also presented, which includes a discussion of the basis for the schedule and cost estimates, contingency assumptions, work breakdown structure, and potential project risks. The schedules and cost estimates will be revised as necessary to reflect appropriate decisions relating to relocation of certain tailings piles, or other special design considerations or circumstances (such as revised EPA groundwater standards), and changes in the Project mission. 27 figs', 97 tabs

Individual single-site travel cost model for Czech paradise geopark

Directory of Open Access Journals (Sweden)

Jan Špaček

2013-01-01

Full Text Available Geotourism is a new phenomenon, which has emerged in the tourism literature during the past two decades, and whose meaning suffered from global census. Geotourism is still a new discipline and relatively little has been written about its demand side, demonstrated by a lack of studies in the literature This article studies the recreational value of geotourism areas, and focuses on the first geopark in the Czech Republic, namely the Czech Paradise Geopark. To assess the recreational value the travel cost method is applied, specifically the individual travel cost model. The necessary research data was gathered through intensive tourist surveys conducted in the study area. Data gathered in the respondents’ survey served to determine the consumer surplus as a measure of recreational value and to develop the single site travel cost model. The dependent variable in the conducted model is the number of visits in the area and among the independent variables, studied age, education, travel cost, family status, economic activity and income. The results were subsequently compared to findings in the available literature, research works and case studies.

29 CFR 1926.752 - Site layout, site-specific erection plan and construction sequence.

Science.gov (United States)

2010-07-01

... 29 Labor 8 2010-07-01 2010-07-01 false Site layout, site-specific erection plan and construction... Steel Erection § 1926.752 Site layout, site-specific erection plan and construction sequence. (a... strength or sufficient strength to support the loads imposed during steel erection. (c) Site layout. The...

How to open & operate a financially successful web site design business

CERN Document Server

Evans, Charlotte

2009-01-01

The Pricing & Ethical Guidelines Handbook published by the Graphic Arts Guild reports that the average cost of designing a Web site for a small corporation can range from 7,750 to 15,000. It is incredibly easy to see the enormous profit potential. Web design businesses can be run part- or full-time and can easily be started in your own home. As such, they are one of the fastest growing segments of the Internet economy. Here is the manual you need to cash in on this highly profitable segment of the industry. This book is a comprehensive and detailed study of the business side of Web site des

Site Specific Vendor's License

Data.gov (United States)

Montgomery County of Maryland — This dataset contains information of a site-specific vendor's license which is required if an individual sells or offers to sell goods or services from a stationary...

Design optimization for cost and quality: The robust design approach

Science.gov (United States)

Unal, Resit

1990-01-01

Designing reliable, low cost, and operable space systems has become the key to future space operations. Designing high quality space systems at low cost is an economic and technological challenge to the designer. A systematic and efficient way to meet this challenge is a new method of design optimization for performance, quality, and cost, called Robust Design. Robust Design is an approach for design optimization. It consists of: making system performance insensitive to material and subsystem variation, thus allowing the use of less costly materials and components; making designs less sensitive to the variations in the operating environment, thus improving reliability and reducing operating costs; and using a new structured development process so that engineering time is used most productively. The objective in Robust Design is to select the best combination of controllable design parameters so that the system is most robust to uncontrollable noise factors. The robust design methodology uses a mathematical tool called an orthogonal array, from design of experiments theory, to study a large number of decision variables with a significantly small number of experiments. Robust design also uses a statistical measure of performance, called a signal-to-noise ratio, from electrical control theory, to evaluate the level of performance and the effect of noise factors. The purpose is to investigate the Robust Design methodology for improving quality and cost, demonstrate its application by the use of an example, and suggest its use as an integral part of space system design process.

A FRAMEWORK FOR LOW-COST MULTI-PLATFORM VR AND AR SITE EXPERIENCES

Directory of Open Access Journals (Sweden)

J. O. Wallgrün

2017-11-01

Full Text Available Low-cost consumer-level immersive solutions have the potential to revolutionize education and research in many fields by providing virtual experiences of sites that are either inaccessible, too dangerous, or too expensive to visit, or by augmenting in-situ experiences using augmented and mixed reality methods. We present our approach for creating low-cost multi-platform virtual and augmented reality site experiences of real world places for education and research purposes, making extensive use of Structure-from-Motion methods as well as 360° photography and videography. We discuss several example projects, for the Mayan City of Cahal Pech, Iceland’s Thrihnukar volcano, the Santa Marta informal settlement in Rio, and for the Penn State Campus, and we propose a framework for creating and maintaining such applications by combining declarative content specification methods with a central linked-data based spatio-temporal information system.

Site restoration: Estimation of attributable costs from plutonium-dispersal accidents

International Nuclear Information System (INIS)

Chanin, D.I.; Murfin, W.B.

1996-05-01

A nuclear weapons accident is an extremely unlikely event due to the extensive care taken in operations. However, under some hypothetical accident conditions, plutonium might be dispersed to the environment. This would result in costs being incurred by the government to remediate the site and compensate for losses. This study is a multi-disciplinary evaluation of the potential scope of the post-accident response that includes technical factors, current and proposed legal requirements and constraints, as well as social/political factors that could influence decision making. The study provides parameters that can be used to assess economic costs for accidents postulated to occur in urban areas, Midwest farmland, Western rangeland, and forest. Per-area remediation costs have been estimated, using industry-standard methods, for both expedited and extended remediation. Expedited remediation costs have been evaluated for highways, airports, and urban areas. Extended remediation costs have been evaluated for all land uses except highways and airports. The inclusion of cost estimates in risk assessments, together with the conventional estimation of doses and health effects, allows a fuller understanding of the post-accident environment. The insights obtained can be used to minimize economic risks by evaluation of operational and design alternatives, and through development of improved capabilities for accident response

Site restoration: Estimation of attributable costs from plutonium-dispersal accidents

Energy Technology Data Exchange (ETDEWEB)

Chanin, D.I.; Murfin, W.B. [Technadyne Engineering Consultants, Inc., Albuquerque, NM (United States)

1996-05-01

A nuclear weapons accident is an extremely unlikely event due to the extensive care taken in operations. However, under some hypothetical accident conditions, plutonium might be dispersed to the environment. This would result in costs being incurred by the government to remediate the site and compensate for losses. This study is a multi-disciplinary evaluation of the potential scope of the post-accident response that includes technical factors, current and proposed legal requirements and constraints, as well as social/political factors that could influence decision making. The study provides parameters that can be used to assess economic costs for accidents postulated to occur in urban areas, Midwest farmland, Western rangeland, and forest. Per-area remediation costs have been estimated, using industry-standard methods, for both expedited and extended remediation. Expedited remediation costs have been evaluated for highways, airports, and urban areas. Extended remediation costs have been evaluated for all land uses except highways and airports. The inclusion of cost estimates in risk assessments, together with the conventional estimation of doses and health effects, allows a fuller understanding of the post-accident environment. The insights obtained can be used to minimize economic risks by evaluation of operational and design alternatives, and through development of improved capabilities for accident response.

Site-Specific Atmospheric Dispersion Characteristics of Korean Nuclear Power Plant Sites

International Nuclear Information System (INIS)

Han, M. H.; Kim, E. H.; Suh, K. S.; Hwang, W. T.; Choi, Y. G.

2001-01-01

Site-specific atmospheric dispersion characteristics have been analyzed. The northwest and the southwest wind prevail on nuclear sites of Korea. The annual isobaric surface averaged for twenty years around Korean peninsula shows that west wind prevails. The prevailing west wind is profitable in the viewpoint of radiation protection because three of four nuclear sites are located in the east side. Large scale field tracer experiments over nuclear sites have been conducted for the purpose of analyzing the atmospheric dispersion characteristics and validating a real-time atmospheric dispersion and dose assessment system FADAS. To analyze the site-specific atmospheric dispersion characteristics is essential for making effective countermeasures against a nuclear emergency

The cost of decommissioning uranium mill tailings

International Nuclear Information System (INIS)

Lush, D.L.; Lendrum, C.; Hostovsky, C.; Eedy, W.; Ashbrook, A.

1986-04-01

This report identifies several key operations that are commonly carried out during decommissioning of tailings areas in the Canadian environment. These operations are unit costed for a generic site to provide a base reference case. The unit costs have also been scaled to the quantities required for the decommissioning of four Canadian sites and these scaled quantities compared with site-specific engineering cost estimates and actual costs incurred in carrying out the decommissioning activities. Variances in costing are discussed. The report also recommends a generic monitoring regime upon which both short- and longer-term environmental monitoring costs are calculated. Although every site must be addressed as a site-specific case, and monitoring programs must be tailored to fit a specific site, it would appear that for the conventional decommissioning and monitoring practices that have been employed to date, costs can be reasonably estimated when site-specific conditions are taken into account

Statistical and Economic Techniques for Site-specific Nematode Management.

Science.gov (United States)

Liu, Zheng; Griffin, Terry; Kirkpatrick, Terrence L

2014-03-01

Recent advances in precision agriculture technologies and spatial statistics allow realistic, site-specific estimation of nematode damage to field crops and provide a platform for the site-specific delivery of nematicides within individual fields. This paper reviews the spatial statistical techniques that model correlations among neighboring observations and develop a spatial economic analysis to determine the potential of site-specific nematicide application. The spatial econometric methodology applied in the context of site-specific crop yield response contributes to closing the gap between data analysis and realistic site-specific nematicide recommendations and helps to provide a practical method of site-specifically controlling nematodes.

Cost effectiveness of risk-based closures at UST sites

International Nuclear Information System (INIS)

Scruton, K.M.; Baker, J.N.

1995-01-01

Risk-based closures have been achieved at Underground Storage Tank (UST) sites throughout the country for a major transportation company. The risk-based closures were cost-effective because a streamlined risk-based approach was used instead of the generic baseline risk assessment approach. USEPA has recently provided guidance encouraging the use of risk-based methodology for achieving closure at UST sites. The risk-based approach used in achieving the site closures involved an identification of potential human and ecological receptors and exposure pathways, and a comparison of maximum onsite chemical concentrations to applicable or relevant and appropriate requirements (ARARs). The ARARs used in the evaluation included Federal and/or State Maximum Contaminant Levels (MCLs) for groundwater and risk-based screening levels for soils. If the maximum concentrations were above the screening levels, a baseline risk assessment was recommended. In several instances, however, the risk-based approach resulted in a regulatory agency acceptance of a ''no further action'' alternative at UST sites which did not pose a significant threat to human health and the environment. The cost of the streamlined risk-based approach is approximately $3,500, while a baseline risk assessment for the same UST site could cost up to $10,000 or more. The use of the streamlined risk-based approach has proven to be successful for achieving a ''no further action'' outcome for the client at a reasonable cost

Establishing a cost model when estimating product cost in early design phases

OpenAIRE

Jeppsson, Johanna; Sjöberg, Jessica

2017-01-01

About 75% of the total product cost is determined in the early design phase, which means that the possibilities to affect costs are relatively small when the design phase is completed. For companies, it is therefore vital to conduct reliable cost estimates in the early design phase, when selecting between different design choices. When conducting a cost estimate there are many uncertainties. The aim with this study is therefore to explore how uncertainties regarding product cost can be consid...

Site-Specific Seismic Site Response Model for the Waste Treatment Plant, Hanford, Washington

Energy Technology Data Exchange (ETDEWEB)

Rohay, Alan C.; Reidel, Steve P.

2005-02-24

This interim report documents the collection of site-specific geologic and geophysical data characterizing the Waste Treatment Plant site and the modeling of the site-specific structure response to earthquake ground motions.

Economics of site-specific and variable-dose herbicide application

DEFF Research Database (Denmark)

Ørum, Jens Erik; Kudsk, Per; Jensen, Peter Kryger

2017-01-01

Site-specific application of pesticides has so far focused mainly on herbicides. The purpose of precision farming technologies in relation to herbicide use is to reduce herbicide cost and environmental impact from spraying, but at the same time to achieve acceptable weed control. Another purpose...... is to increase the spraying capacity, to reduce the number of sprayer refills, and finally to minimize time spent on weed monitoring. In this chapter the relevance and profitability of four precision herbicide application technologies, two weed detection technologies and a low dose decision support system (DSS......) is analysed. With a low dose herbicide, cost can be reduced by 20–50%. It requires, however, proper monitoring of weeds, which can be a time-consuming task that again requires that the farmer is able to identify the dominant weed species. The current development of high-speed camera and software systems can...

Procurement Specifications Templates for On-Site Solar Photovoltaic: For Use in Developing Federal Solicitations

Energy Technology Data Exchange (ETDEWEB)

Robinson, G. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2017-01-16

With the increasing adaption of on-site renewable energy systems designed to feed site loads, there is a critical need to develop tools that allow the federal sector to become a mature and sophisticated consumer. This document is intended to reduce project development and operational risks while increasing the speed at which projects are completed; two necessary components to reach the scale required to meet mandates and achieve cost savings for taxpayers. This guide is intended to act as a living document where lessons learned from the increasing number of projects can be incorporated and provide guidance for efforts. While additional guides will be developed to cover other renewable technologies, this guide covers on-site solar photovoltaic systems with an emphasis on third-party designed, financed, owned, and operated systems.

Discovery of Nigri/nox and Panto/pox site-specific recombinase systems facilitates advanced genome engineering.

Science.gov (United States)

Karimova, Madina; Splith, Victoria; Karpinski, Janet; Pisabarro, M Teresa; Buchholz, Frank

2016-07-22

Precise genome engineering is instrumental for biomedical research and holds great promise for future therapeutic applications. Site-specific recombinases (SSRs) are valuable tools for genome engineering due to their exceptional ability to mediate precise excision, integration and inversion of genomic DNA in living systems. The ever-increasing complexity of genome manipulations and the desire to understand the DNA-binding specificity of these enzymes are driving efforts to identify novel SSR systems with unique properties. Here, we describe two novel tyrosine site-specific recombination systems designated Nigri/nox and Panto/pox. Nigri originates from Vibrio nigripulchritudo (plasmid VIBNI_pA) and recombines its target site nox with high efficiency and high target-site selectivity, without recombining target sites of the well established SSRs Cre, Dre, Vika and VCre. Panto, derived from Pantoea sp. aB, is less specific and in addition to its native target site, pox also recombines the target site for Dre recombinase, called rox. This relaxed specificity allowed the identification of residues that are involved in target site selectivity, thereby advancing our understanding of how SSRs recognize their respective DNA targets.

Site-specific analysis of hybrid geothermal/fossil power plants. Volume One. Roosevelt Hot Springs KGRA

Energy Technology Data Exchange (ETDEWEB)

1977-06-01

The economics of a particular hybrid plant must be evaluated with respect to a specific site. This volume focuses on the Roosevelt Hot Springs KGRA. The temperature, pressure, and flow rate data given suggests the site deserves serious consideration for a hybrid plant. Key siting considerations which must be addressed before an economic judgment can be attempted are presented as follows: the availability, quality, and cost of coal; the availability of water; and the availability of transmission. Seismological and climate factors are presented. (MHR)

Green Infrastructure Siting and Cost Effectiveness Analysis

Data.gov (United States)

Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Parcel scale green infrastructure siting and cost effectiveness analysis. You can find more details at the project's website.

Species-specific spatial characteristics in reserve site selection

NARCIS (Netherlands)

Groeneveld, R.A.

2010-01-01

This paper addresses the problem of selecting reserve sites cost-effectively, taking into account the mobility and habitat area requirements of each species. Many reserve site selection problems are analyzed in mixed-integer linear programming (MILP) models due to the mathematical solvers available

Hanford Site Environmental Management Specification

International Nuclear Information System (INIS)

DAILY, J.L.

2001-01-01

The US Department of Energy, Richland Operations Office (RL) has established a document hierarchy as part of its integrated management system. The Strategic Plan defines the vision, values, missions, strategic goals, high-level outcomes, and the basic strategies in achieving those outcomes. As shown in Figure 1-1, the Site Specification derives requirements from the Strategic Plan and documents the top-level mission technical requirements for the work involved in the RL Hanford Site cleanup and infrastructure activities under the responsibility of the U.S. Department of Energy, Office of Environmental Management (EM). It also provides the basis for all contract technical requirements. Since this is limited to the EM work, neither the Fast Flux Test Facility (FFTF) nor the Pacific Northwest National Laboratory (PNNL) non-EM science activities are included. Figure 1-1 also shows the relationship between this Site Specification and the other Site management and planning documents. Similarly, the documents, orders, and laws referenced in this document represent only the most salient sources of requirements. Current and contractual reference data contain a complete set of source documents

Vika/vox, a novel efficient and specific Cre/loxP-like site-specific recombination system

Science.gov (United States)

Karimova, Madina; Abi-Ghanem, Josephine; Berger, Nicolas; Surendranath, Vineeth; Pisabarro, Maria Teresa; Buchholz, Frank

2013-01-01

Targeted genome engineering has become an important research area for diverse disciplines, with site-specific recombinases (SSRs) being among the most popular genome engineering tools. Their ability to trigger excision, integration, inversion and translocation has made SSRs an invaluable tool to manipulate DNA in vitro and in vivo. However, sophisticated strategies that combine different SSR systems are ever increasing. Hence, the demand for additional precise and efficient recombinases is dictated by the increasing complexity of the genetic studies. Here, we describe a novel site-specific recombination system designated Vika/vox. Vika originates from a degenerate bacteriophage of Vibrio coralliilyticus and shares low sequence similarity to other tyrosine recombinases, but functionally carries out a similar type of reaction. We demonstrate that Vika is highly specific in catalyzing vox recombination without recombining target sites from other SSR systems. We also compare the recombination activity of Vika/vox with other SSR systems, providing a guideline for deciding on the most suitable enzyme for a particular application and demonstrate that Vika expression does not cause cytotoxicity in mammalian cells. Our results show that Vika/vox is a novel powerful and safe instrument in the ‘genetic toolbox’ that can be used alone or in combination with other SSRs in heterologous hosts. PMID:23143104

Cone penetrometer testing and discrete-depth groundwater sampling techniques: A cost-effective method of site characterization in a multiple-aquifer setting

International Nuclear Information System (INIS)

Zemo, D.A.; Pierce, Y.G.; Gallinatti, J.D.

1992-01-01

Cone penetrometer testing (CPT), combined with discrete-depth groundwater sampling methods, can reduce significantly the time and expense required to characterize large sites that have multiple aquifers. Results from the screening site characterization can be used to design and install a cost-effective monitoring well network. At a site in northern California, it was necessary to characterize the stratigraphy and the distribution of volatile organic compounds (VOCs) to a depth of 80 feet within a 1/2 mile-by-1/4-mile residential and commercial area in a complex alluvial fan setting. To expedite site characterization, a five-week field screening program was implemented that consisted of a shallow groundwater survey, CPT soundings, and discrete-depth groundwater sampling. Based on continuous lithologic information provided by the CPT soundings, four coarse-grained water-yielding sedimentary packages were identified. Eighty-three discrete-depth groundwater samples were collected using shallow groundwater survey techniques, the BAT Enviroprobe, or the QED HydroPunch 1, depending on subsurface conditions. A 20-well monitoring network was designed and installed to monitor critical points within each sedimentary package. Understanding the vertical VOC distribution and concentrations produced substantial cost savings by minimizing the number of permanent monitoring wells and reducing the number of costly conductor casings to be installed. Significant long-term cost savings will result from reduced sampling costs. Where total VOC concentrations exceeded 20 φg/l in the screening samples, a good correlation was found between the discrete-depth screening data and data from monitoring wells. Using a screening program to characterize the site before installing monitoring wells resulted in an estimated 50-percent reduction in costs for site characterization, 65-percent reduction in time for site characterization, and 50-percent reduction in long-term monitoring costs

A Cost-based Explanation of Gradual, Regional Internationalization of Multinationals on Social Networking Sites

DEFF Research Database (Denmark)

Pogrebnyakov, Nicolai

2017-01-01

This paper examines firm internationalization on social networking sites (SNS). It systematically examines costs faced by an internationalizing firm and how firms react to these costs according to “distance-dependent” (gradual and regional) and “distance-invariant” (born-global) explanations...... of internationalization. Data on 5827 country pages of 240 multinational firms on Facebook, the most popular SNS today, is used. Creating a foreign country-specific Facebook page is considered the SNS equivalent of opening a physical subsidiary in that country. The data show that multinationals exhibit...

Design of multi-specificity in protein interfaces.

Directory of Open Access Journals (Sweden)

Elisabeth L Humphris

2007-08-01

Full Text Available Interactions in protein networks may place constraints on protein interface sequences to maintain correct and avoid unwanted interactions. Here we describe a "multi-constraint" protein design protocol to predict sequences optimized for multiple criteria, such as maintaining sets of interactions, and apply it to characterize the mechanism and extent to which 20 multi-specific proteins are constrained by binding to multiple partners. We find that multi-specific binding is accommodated by at least two distinct patterns. In the simplest case, all partners share key interactions, and sequences optimized for binding to either single or multiple partners recover only a subset of native amino acid residues as optimal. More interestingly, for signaling interfaces functioning as network "hubs," we identify a different, "multi-faceted" mode, where each binding partner prefers its own subset of wild-type residues within the promiscuous binding site. Here, integration of preferences across all partners results in sequences much more "native-like" than seen in optimization for any single binding partner alone, suggesting these interfaces are substantially optimized for multi-specificity. The two strategies make distinct predictions for interface evolution and design. Shared interfaces may be better small molecule targets, whereas multi-faceted interactions may be more "designable" for altered specificity patterns. The computational methodology presented here is generalizable for examining how naturally occurring protein sequences have been selected to satisfy a variety of positive and negative constraints, as well as for rationally designing proteins to have desired patterns of altered specificity.

Optimal Vehicle Design Using the Integrated System and Cost Modeling Tool Suite

Science.gov (United States)

2010-08-01

Space Vehicle Costing ( ACEIT ) • New Small Sat Model Development & Production Cost O&M Cost Module  Radiation Exposure  Radiation Detector Response...Reliability OML Availability Risk l l Tools CEA, SRM Model, POST, ACEIT , Inflation Model, Rotor Blade Des, Microsoft Project, ATSV, S/1-iABP...space STK, SOAP – Specific mission • Space Vehicle Design (SMAD) • Space Vehicle Propulsion • Orbit Propagation • Space Vehicle Costing ( ACEIT ) • New

Site-specific calibration of the Hanford personnel neutron dosimeter

International Nuclear Information System (INIS)

Endres, A.W.; Brackenbush, L.W.; Baumgartner, W.V.; Rathbone, B.A.

1994-10-01

A new personnel dosimetry system, employing a standard Hanford thermoluminescent dosimeter (TLD) and a combination dosimeter with both CR-39 nuclear track and TLD-albedo elements, is being implemented at Hanford. Measurements were made in workplace environments in order to verify the accuracy of the system and establish site-specific factors to account for the differences in dosimeter response between the workplace and calibration laboratory. Neutron measurements were performed using sources at Hanford's Plutonium Finishing Plant under high-scatter conditions to calibrate the new neutron dosimeter design to site-specific neutron spectra. The dosimeter was also calibrated using bare and moderated 252 Cf sources under low-scatter conditions available in the Hanford Calibration Laboratory. Dose equivalent rates in the workplace were calculated from spectrometer measurements using tissue equivalent proportional counter (TEPC) and multisphere spectrometers. The accuracy of the spectrometers was verified by measurements on neutron sources with calibrations directly traceable to the National Institute of Standards and Technology (NIST)

Savannah River Site production reactor technical specifications. K Production Reactor

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-02-01

These technical specifications are explicit restrictions on the operation of the Savannah River Site K Production Reactor. They are designed to preserve the validity of the plant safety analysis by ensuring that the plant is operated within the required conditions bounded by the analysis, and with the operable equipment that is assumed to mitigate the consequences of an accident. Technical specifications preserve the primary success path relied upon to detect and respond to accidents. This report describes requirements on thermal-hydraulic limits; limiting conditions for operation and surveillance for the reactor, power distribution control, instrumentation, process water system, emergency cooling and emergency shutdown systems, confinement systems, plant systems, electrical systems, components handling, and special test exceptions; design features; and administrative controls.

Designing a responsive web site

OpenAIRE

Fejzić , Diana

2016-01-01

Due to the increasing prevalence of smartphones and tablet computers design became a crucial part of web design. For a user, responsive web design enables the best user experience, regardless of whether a user is visiting the site via a mobile phone, a tablet or a computer. This thesis covers the process of planning, designing and responsive web site development, for a fictitious company named “Creative Design d.o.o.”, with the help of web technologies. In the initial part of the thesis, w...

Preconceptual design studies and cost data of depleted uranium hexafluoride conversion plants

International Nuclear Information System (INIS)

Jones, E

1999-01-01

One of the more important legacies left with the Department of Energy (DOE) after the privatization of the United States Enrichment Corporation is the large inventory of depleted uranium hexafluoride (DUF6). The DOE Office of Nuclear Energy, Science and Technology (NE) is responsible for the long-term management of some 700,000 metric tons of DUF6 stored at the sites of the two gaseous diffusion plants located at Paducah, Kentucky and Portsmouth, Ohio, and at the East Tennessee Technology Park in Oak Ridge, Tennessee. The DUF6 management program resides in NE's Office of Depleted Uranium Hexafluoride Management. The current DUF6 program has largely focused on the ongoing maintenance of the cylinders containing DUF6. However, the long-term management and eventual disposition of DUF6 is the subject of a Programmatic Environmental Impact Statement (PEIS) and Public Law 105-204. The first step for future use or disposition is to convert the material, which requires construction and long-term operation of one or more conversion plants. To help inform the DUF6 program's planning activities, it was necessary to perform design and cost studies of likely DUF6 conversion plants at the preconceptual level, beyond the PEIS considerations but not as detailed as required for conceptual designs of actual plants. This report contains the final results from such a preconceptual design study project. In this fast track, three month effort, Lawrence Livermore National Laboratory and Bechtel National Incorporated developed and evaluated seven different preconceptual design cases for a single plant. The preconceptual design, schedules, costs, and issues associated with specific DUF6 conversion approaches, operating periods, and ownership options were evaluated based on criteria established by DOE. The single-plant conversion options studied were similar to the dry-conversion process alternatives from the PEIS. For each of the seven cases considered, this report contains information on

Prosthetic design directives: Low-cost hands within reach.

Science.gov (United States)

Jones, G K; Rosendo, A; Stopforth, R

2017-07-01

Although three million people around the world suffer from the lack of one or both upper limbs 80% of this number is located within developing countries. While prosthetic prices soar with technology 3D printing and low cost electronics present a sensible solution for those that cannot afford expensive prosthetics. The electronic and control design of a low-cost prosthetic hand, the Touch Hand II, is discussed. This paper shows that sensorless techniques can be used to reduce design complexities, costs, and provide easier access to the electronics. A closing and opening finite state machine (COFSM) was developed to handle the actuated digit joint control state and a supervisory switching control scheme, used for speed and grip strength control. Three torque and speed settings were created to be preset for specific grasps. The hand was able to replicate ten frequently used grasps and grip some common objects. Future work is necessary to enable a user to control it with myoelectric signals (MESs) and to solve operational problems related to electromagnetic interference (EMI).

Cost Effectiveness of On-site versus Off-site Depression Collaborative Care in Rural Federally Qualified Health Centers

Science.gov (United States)

Pyne, Jeffrey M.; Fortney, John C.; Mouden, Sip; Lu, Liya; Hudson, Teresa J; Mittal, Dinesh

2018-01-01

Objective Collaborative care for depression is effective and cost-effective in primary care settings. However, there is minimal evidence to inform the choice of on-site versus off-site models. This study examined the cost-effectiveness of on-site practice-based collaborative care (PBCC) versus off-site telemedicine-based collaborative care (TBCC) for depression in Federally Qualified Health Centers (FQHCs). Methods Multi-site randomized pragmatic comparative cost-effectiveness trial. 19,285 patients were screened for depression, 14.8% (n=2,863) screened positive (PHQ9 ≥10) and 364 were enrolled. Telephone interview data were collected at baseline, 6-, 12-, and 18-months. Base case analysis used Arkansas FQHC healthcare costs and secondary analysis used national cost estimates. Effectiveness measures were depression-free days and quality-adjusted life years (QALYs) derived from depression-free days, Medical Outcomes Study SF-12, and Quality of Well Being scale (QWB). Nonparametric bootstrap with replacement methods were used to generate an empirical joint distribution of incremental costs and QALYs and acceptability curves. Results Mean base case FQHC incremental cost-effectiveness ratio (ICER) using depression-free days was $10.78/depression-free day. Mean base case ICERs using QALYs ranged from $14,754/QALY (depression-free day QALY) to $37,261/QALY (QWB QALY). Mean secondary national ICER using depression-free days was $8.43/depression-free day and using QALYs ranged from $11,532/QALY (depression-free day QALY) to $29,234/QALY (QWB QALY). Conclusions These results support the cost-effectiveness of the TBCC intervention in medically underserved primary care settings. Results can inform the decision about whether to insource (make) or outsource (buy) depression care management in the FQHC setting within the current context of Patient-Centered Medical Home, value-based purchasing, and potential bundled payments for depression care. The www.clinicaltrials.gov # for

A systematic identification of species-specific protein succinylation sites using joint element features information

Directory of Open Access Journals (Sweden)

Hasan MM

2017-08-01

Full Text Available Md Mehedi Hasan,1 Mst Shamima Khatun,2 Md Nurul Haque Mollah,2 Cao Yong,3 Dianjing Guo1 1School of Life Sciences and the State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, New Territory, Hong Kong, People’s Republic of China; 2Laboratory of Bioinformatics, Department of Statistics, University of Rajshahi, Rajshahi, Bangladesh; 3Department of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen Graduate School, Shenzhen, People’s Republic of China Abstract: Lysine succinylation, an important type of protein posttranslational modification, plays significant roles in many cellular processes. Accurate identification of succinylation sites can facilitate our understanding about the molecular mechanism and potential roles of lysine succinylation. However, even in well-studied systems, a majority of the succinylation sites remain undetected because the traditional experimental approaches to succinylation site identification are often costly, time-consuming, and laborious. In silico approach, on the other hand, is potentially an alternative strategy to predict succinylation substrates. In this paper, a novel computational predictor SuccinSite2.0 was developed for predicting generic and species-specific protein succinylation sites. This predictor takes the composition of profile-based amino acid and orthogonal binary features, which were used to train a random forest classifier. We demonstrated that the proposed SuccinSite2.0 predictor outperformed other currently existing implementations on a complementarily independent dataset. Furthermore, the important features that make visible contributions to species-specific and cross-species-specific prediction of protein succinylation site were analyzed. The proposed predictor is anticipated to be a useful computational resource for lysine succinylation site prediction. The integrated species-specific online tool of SuccinSite2.0 is publicly

Designing to target cost: one approach to design/construction integration

DEFF Research Database (Denmark)

Jørgensen, Bo

2005-01-01

One approach to a more integrated construction delivery process is the concept of ‘designing to target cost’ of which the first examples of application within a lean construction framework have recently been seen. This paper introduces the main principles of the design to target cost method...... and discusses the applicability of this approach to construction. The low degree of organizational and technical continuity from one construction project to the next limits the applicability of the design for target cost approach when compared to its origin in product development of mass manufactured artefacts....... It can be argued that design to target cost may also provide a frame for developing the supply chain towards better coordination and collaboration. Thus methods of design to target cost may serve to facilitate the development of a more integrated supply chain....

Low-cost satellite mechanical design and construction

Science.gov (United States)

Boisjolie-Gair, Nathaniel; Straub, Jeremy

2017-05-01

This paper presents a discussion of techniques for low-cost design and construction of a CubeSat mechanical structure that can serve as a basis for academic programs and a starting point for government, military and commercial large-scale sensing networks, where the cost of each node must be minimized to facilitate system affordability and lower the cost and associated risk of losing any node. Spacecraft Design plays a large role in manufacturability. An intentionally simplified mechanical design is presented which reduces machining costs, as compared to more intricate designs that were considered. Several fabrication approaches are evaluated relative to the low-cost goal.

Towards soft robotic devices for site-specific drug delivery.

Science.gov (United States)

Alici, Gursel

2015-01-01

Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) that are mechanical/physical, chemical and biological/molecular DDS. In this paper, we report on the recent advances in site-specific drug delivery (site-specific, controlled, targeted or smart drug delivery are terms used interchangeably in the literature, to mean to transport a drug or a therapeutic agent to a desired location within the body and release it as desired with negligibly small toxicity and side effect compared to classical drug administration means such as peroral, parenteral, transmucosal, topical and inhalation) based on mechanical/physical systems consisting of implantable and robotic drug delivery systems. While we specifically focus on the robotic or autonomous DDS, which can be reprogrammable and provide multiple doses of a drug at a required time and rate, we briefly cover the implanted DDS, which are well-developed relative to the robotic DDS, to highlight the design and performance requirements, and investigate issues associated with the robotic DDS. Critical research issues associated with both DDSs are presented to describe the research challenges ahead of us in order to establish soft robotic devices for clinical and biomedical applications.

TU-A-201-02: Treatment Site-Specific Considerations for Clinical IGRT

Energy Technology Data Exchange (ETDEWEB)

Wijesooriya, K. [University of Virginia Health Systems (United States)

2016-06-15

Recent years have seen a widespread proliferation of available in-room image guidance systems for radiation therapy target localization with many centers having multiple in-room options. In this session, available imaging systems for in-room IGRT will be reviewed highlighting the main differences in workflow efficiency, targeting accuracy and image quality as it relates to target visualization. Decision-making strategies for integrating these tools into clinical image guidance protocols that are tailored to specific disease sites like H&N, lung, pelvis, and spine SBRT will be discussed. Learning Objectives: Major system characteristics of a wide range of available in-room imaging systems for IGRT. Advantages / disadvantages of different systems for site-specific IGRT considerations. Concepts of targeting accuracy and time efficiency in designing clinical imaging protocols.

Radiotracers for per studies of neurotransmitter binding sites: Design considerations

International Nuclear Information System (INIS)

Kilbourn, M.R.

1991-01-01

Neurotransmitter binding sites, such as receptors, neuronal uptake systems, and vesicular uptake systems, are important targets for new radiopharmaceutical design. Selection of potential radioligands can be guided by in vitro laboratory data including such characteristics as selectivity and affinity for specific binding sites. However, development of PET radiotracers for use in vivo must include considerations of in vivo pharmacokinetics and metabolism. Introduction of potential radioligands is further narrowed by the demands of the radiochemical synthesis, which must produce radioligands of high chemical and radiochemical purity and of high specific activity. This paper will review examples of previous and current attempts by radiopharmaceutical chemists to meet these demands for new positron emitter-labeled radioligands for PET studies of a wide array of neurotransmitter binding sites

Systematic approach to designing surface covers for uranium-mill tailings

International Nuclear Information System (INIS)

Beedlow, P.A.; Cadwell, L.L.; McShane, M.C.

1982-01-01

The wide range of environmental conditions present at uranium mill tailings sites precludes the use of a single type of surface cover. Surface covers must be designed on a site-specific basis. To facilitate site specific designs the UMTRA program is developing guidelines for designing surface covers. This paper presents a systematic approach to designing surface covers for tailings that can be applied under any site condition. The approach consists of three phases: (1) An assessment during which the degree of surface protection is determined. (2) A preliminary design that facilitates interaction with those designing other containment system elements. (3) A final design where the cost and effectiveness of the surface cover are determined. The types of information required to apply this approach are discussed

Gas-cooled fast-breeder reactor. Helium Circulator Test Facility updated design cost estimate

International Nuclear Information System (INIS)

1979-04-01

Costs which are included in the cost estimate are: Titles I, II, and III Architect-Engineering Services; Titles I, II, and III General Atomic Services; site clearing, grading, and excavation; bulk materials and labor of installation; mechanical and electrical equipment with installation; allowance for contractors' overhead, profit, and insurance; escalation on materials and labor; a contingency; and installation of GAC supplied equipment and materials. The total estimated cost of the facility in As Spent Dollars is $27,700,000. Also included is a cost comparison of the updated design and the previous conceptual design. There would be a considerable penalty for the direct-cooled system over the indirect-cooled system due to the excessive cost of the large diameter helium loop piping to an outdoor heat exchanger. The indirect cooled system which utilizes a helium/Dowtherm G heat exchanger and correspondingly smaller and lower pressure piping to its outdoor air cooler proved to be the more economical of the two systems

SU-D-BRC-02: Application of Six Sigma Approach to Improve the Efficiency of Patient-Specific QA in Proton Therapy

International Nuclear Information System (INIS)

LAH, J; Shin, D; Manger, R; Kim, G

2016-01-01

Purpose: To show how the Six Sigma DMAIC (Define-Measure-Analyze-Improve-Control) can be used for improving and optimizing the efficiency of patient-specific QA process by designing site-specific range tolerances. Methods: The Six Sigma tools (process flow diagram, cause and effect, capability analysis, Pareto chart, and control chart) were utilized to determine the steps that need focus for improving the patient-specific QA process. The patient-specific range QA plans were selected according to 7 treatment site groups, a total of 1437 cases. The process capability index, Cpm was used to guide the tolerance design of patient site-specific range. We also analyzed the financial impact of this project. Results: Our results suggested that the patient range measurements were non-capable at the current tolerance level of ±1 mm in clinical proton plans. The optimized tolerances were calculated for treatment sites. Control charts for the patient QA time were constructed to compare QA time before and after the new tolerances were implemented. It is found that overall processing time was decreased by 24.3% after establishing new site-specific range tolerances. The QA failure for whole process in proton therapy would lead up to a 46% increase in total cost. This result can also predict how costs are affected by changes in adopting the tolerance design. Conclusion: We often believe that the quality and performance of proton therapy can easily be improved by merely tightening some or all of its tolerance requirements. This can become costly, however, and it is not necessarily a guarantee of better performance. The tolerance design is not a task to be undertaken without careful thought. The Six Sigma DMAIC can be used to improve the QA process by setting optimized tolerances. When tolerance design is optimized, the quality is reasonably balanced with time and cost demands.

SU-D-BRC-02: Application of Six Sigma Approach to Improve the Efficiency of Patient-Specific QA in Proton Therapy

Energy Technology Data Exchange (ETDEWEB)

LAH, J [Myongji Hospital, Goyang-si (Korea, Republic of); Shin, D [Proton Therapy Center, National Cancer Center, Goyang (Korea, Republic of); Manger, R; Kim, G [University of California, San Diego, La Jolla, CA (United States)

2016-06-15

Purpose: To show how the Six Sigma DMAIC (Define-Measure-Analyze-Improve-Control) can be used for improving and optimizing the efficiency of patient-specific QA process by designing site-specific range tolerances. Methods: The Six Sigma tools (process flow diagram, cause and effect, capability analysis, Pareto chart, and control chart) were utilized to determine the steps that need focus for improving the patient-specific QA process. The patient-specific range QA plans were selected according to 7 treatment site groups, a total of 1437 cases. The process capability index, Cpm was used to guide the tolerance design of patient site-specific range. We also analyzed the financial impact of this project. Results: Our results suggested that the patient range measurements were non-capable at the current tolerance level of ±1 mm in clinical proton plans. The optimized tolerances were calculated for treatment sites. Control charts for the patient QA time were constructed to compare QA time before and after the new tolerances were implemented. It is found that overall processing time was decreased by 24.3% after establishing new site-specific range tolerances. The QA failure for whole process in proton therapy would lead up to a 46% increase in total cost. This result can also predict how costs are affected by changes in adopting the tolerance design. Conclusion: We often believe that the quality and performance of proton therapy can easily be improved by merely tightening some or all of its tolerance requirements. This can become costly, however, and it is not necessarily a guarantee of better performance. The tolerance design is not a task to be undertaken without careful thought. The Six Sigma DMAIC can be used to improve the QA process by setting optimized tolerances. When tolerance design is optimized, the quality is reasonably balanced with time and cost demands.

Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation.

Science.gov (United States)

Thoemmes, Stephen F; Stutzke, Crystal A; Du, Yanmei; Browning, Michael D; Buttrick, Peter M; Walker, Lori A

2014-01-31

Phosphorylation of cardiac troponin I is a well established mechanism by which cardiac contractility is modulated. However, there are a number of phosphorylation sites on TnI which contribute singly or in combination to influence cardiac function. Accordingly, methods for accurately measuring site-specific TnI phosphorylation are needed. Currently, two strategies are employed: mass spectrometry, which is costly, difficult and has a low throughput; and Western blotting using phospho-specific antibodies, which is limited by the availability of reagents. In this report, we describe a cohort of new site-specific TnI phosphoantibodies, generated against physiologically relevant phosphorylation sites, that are superior to the current commercially available antibodies: to phospho-serine 22/23 which shows a >5-fold phospho-specificity for phosphorylated TnI; to phospho-serine 43, which has >3-fold phospho-specificity for phosphorylated TnI; and phospho-serine 150 which has >2-fold phospho-specificity for phosphorylated TnI. These new antibodies demonstrated greater sensitivity and specificity for the phosphorylated TnI than the most widely used commercially available reagents. For example, at a protein load of 20 μg of total cardiac extract, a commercially available antibody recognized both phosphorylated and dephosphorylated TnI to the same degree. At the same protein load our phospho-serine 22/23 antibody exhibited no cross-reactivity with dephosphorylated TnI. These new tools should allow a more accurate assessment and a better understanding of the role of TnI phosphorylation in the response of the heart to pathologic stress. Copyright © 2013 Elsevier B.V. All rights reserved.

COST IMPACT OF ROD CONSOLIDATION ON THE VIABILITY ASSESSMENT DESIGN

International Nuclear Information System (INIS)

D. Lancaster

1999-01-01

The cost impact to the Civilian Radioactive Waste Management System of using rod consolidation is evaluated. Previous work has demonstrated that the fuel rods of two assemblies can be packed into a canister that can fit into the same size space as that used to store a single assembly. The remaining fuel assembly hardware can be compacted into the same size canisters with a ratio of 1 hardware canister per each 6 to 12 assemblies. Transportation casks of the same size as currently available can load twice the number of assemblies by placing the compacted assemblies in the slots currently designed for a single assembly. Waste packages similarly could contain twice the number of assemblies; however, thermal constraints would require considering either a low burnup or cooling. The analysis evaluates the impact of rod consolidation on CRWMS costs for consolidation at prior to transportation and for consolidation at the Monitored Geological Repository surface facility. For this study, no design changes were made to either the transport casks or waste packages. Waste package designs used for the Viability Assessment design were employed but derated to make the thermal limits. A logistics analysis of the waste was performed to determine the number of each waste package with each loading. A review of past rod consolidation experience found cost estimates which range from $10/kgU to $32/kgU. $30/kgU was assumed for rod consolidation costs prior to transportation. Transportation cost savings are about $17/kgU and waste package cost savings are about $21/kgU. The net saving to the system is approximately $500 million if the consolidation is performed prior to transportation. If consolidation were performed at the repository surface facilities, it would cost approximately $15/kgU. No transportation savings would be realized. The net savings for consolidation at the repository site would be about $400 million dollars

Savannah River Site's Site Specific Plan

International Nuclear Information System (INIS)

1991-01-01

This Site Specific Plan (SSP) has been prepared by the Savannah River Site (SRS) in order to show the Environmental Restoration and Waste Management activities that were identified during the preparation of the Department of Energy-Headquarters (DOE-HQ) Environmental Restoration and Waste Management Five-Year Plan (FYP) for FY 1992--1996. The SSP has been prepared in accordance with guidance received from DOE-HQ. DOE-SR is accountable to DOE-HQ for the implementation of this plan. The purpose of the SSP is to develop a baseline for policy, budget, and schedules for the DOE Environmental Restoration and Waste Management activities. The plan explains accomplishments since the Fiscal Year (FY) 1990 plan, demonstrates how present and future activities are prioritized, identifies currently funded activities and activities that are planned to be funded in the upcoming fiscal year, and describes future activities that SRS is considering

Design considerations for on-site spent-fuel transfer systems

International Nuclear Information System (INIS)

Jones, R.H.; Jones, C.R.

1989-06-01

Studies on spent fuel shipping logistics and operation make it clear that the use of large casks, i.e., 100--125 tons, is superior to smaller casks of similar construction. This superiority manifests itself in both transportation and/or shipping economics and safety as well as reduced personnel exposure in the processing of the casks. An on-site system for the transfer of spent fuel from the storage pool to a large shipping or storage cask, as well as the transfer of spent fuel directly from a storage cask to a shipping cask, could bring the large cask benefits to those restricted reactors. Sensing the need to look more closely at this opportunity, EPRI contracted with S. Levy, Incorporated of Campbell, CA to develop a set of design considerations for such transfer systems. Rather then embark on another design study, EPRI decided to first identify the system considerations that must be factored into any design. The format for this effort presents both the Consideration and the Rationale for the consideration. The resulting work identified thirty-six General Considerations and two Special Considerations. The Considerations are in the form of mandatory requirements and desirable but nonmandatory requirements. Additionally, a brief economic study was performed to get a feel for the cost considerations of on-site transfers. The study results suggest a relatively narrow set of scenarios where on-site transfers are economically superior to alternatives. These scenarios generally involve the use of concrete casks as on-site storage devices

Design of photovoltaic central power station concentrator array

Energy Technology Data Exchange (ETDEWEB)

1984-02-01

A design for a photovoltaic central power station using tracking concentrators has been developed. The 100 MW plant is assumed to be located adjacent to the Saguaro Power Station of Arizona Public Service. The design assumes an advanced Martin Marietta two-axis tracking fresnel lens concentrator. The concentrators are arrayed in 5 MW subfields, each with its own power conditioning unit. The photovoltaic plant output is connected to the existing 115 kV switchyard. The site specific design allows detailed cost estimates for engineering, site preparation, and installation. Collector and power conditioning costs have been treated parametrically.

Site specific plan

International Nuclear Information System (INIS)

Hutchison, J.; Jernigan, G.

1989-12-01

The Environmental Restoration and Waste Management Five-Year Plan (FYP) covers the period for FY 1989 through FY 1995. The plan establishes a Department of Energy -- Headquarters (DOE-HQ) agenda for cleanup and compliance against which overall progress can be measured. The FYP covers three areas: Corrective Activities, Environmental Restoration, and Waste Management Operations. Corrective Activities are those activities necessary to bring active or standby facilities into compliance with local, state, and federal environmental regulations. Environmental restoration activities include the assessment and cleanup of surplus facilities and inactive waste sites. Waste management operations includes the treatment, storage, and disposal of wastes which are generated as a result of ongoing operations. This Site Specific Plan (SSP) has been prepared by the Savannah River Site (SRS) in order to show how environmental restoration and waste management activities that were identified during the preparation of the FYP will be implemented, tracked, and reported. The SSP describes DOE Savannah River (DOE-SR) and operating contractor, Westinghouse Savannah River Company (WSRC), organizations that are responsible, for undertaking the activities identified in this plan. The SSP has been prepared in accordance with guidance received from DOE-HQ. DOE-SR is accountable to DOE-HQ for the implementation of this plan. 8 refs., 46 figs., 23 tabs

Cost estimates and economic evaluations for conceptual LLRW disposal facility designs

Energy Technology Data Exchange (ETDEWEB)

Baird, R.D.; Chau, N. [Rogers & Associates Engineering Corp., Salt Lake City, UT (United States); Breeds, C.D. [SubTerra, Inc., Redmond, WA (United States)

1995-12-31

Total life-cycle costs were estimated in support of the New York LLRW Siting Commission`s project to select a disposal method from four near-surface LLRW disposal methods (namely, uncovered above-grade vaults, covered above-grade vaults, below-grade vaults, and augered holes) and two mined methods (namely, vertical shaft mines and drift mines). Conceptual designs for the disposal methods were prepared and used as the basis for the cost estimates. Typical economic performance of each disposal method was assessed. Life-cycle costs expressed in 1994 dollars ranged from $ 1,100 million (for below-grade vaults and both mined disposal methods) to $2,000 million (for augered holes). Present values ranged from $620 million (for below-grade vaults) to $ 1,100 million (for augered holes).

Innovation and Diffusion of Site-specific Crop Management

DEFF Research Database (Denmark)

Pedersen, Søren Marcus; Pedersen, Jørgen Lindgaard

2006-01-01

Site-specific crop management or precision farming is a highly complex managementsystem for site-specific input application of lime, fertilizers and pesticides in arable farming. The Global Positioning System (GPS)is the backbone of the system. To conduct precision farming several technical systems...

Testing of toxicity based methods to develop site specific clean up objectives - phase 1: Toxicity protocol screening and applicability

International Nuclear Information System (INIS)

Hamilton, H.; Kerr, D.; Thorne, W.; Taylor, B.; Zadnik, M.; Goudey, S.; Birkholz, D.

1994-03-01

A study was conducted to develop a cost-effective and practical protocol for using bio-assay based toxicity assessment methods for remediation of decommissioned oil and gas production, and processing facilities. The objective was to generate site-specific remediation criteria for contaminated sites. Most companies have used the chemical-specific approach which, however, did not meet the ultimate land use goal of agricultural production. The toxicity assessment method described in this study dealt with potential impairment to agricultural crop production and natural ecosystems. Human health concerns were not specifically addressed. It was suggested that chemical-specific methods should be used when human health concerns exist. . Results showed that toxicity tests will more directly identify ecological stress caused by site contamination than chemical-specific remediation criteria, which can be unnecessarily protective. 11 refs., 7 tabs., 6 figs

Innovation and diffusion of site-specific crop management

DEFF Research Database (Denmark)

Pedersen, Søren Marcus; Pedersen, Jørgen Lindgaard

2004-01-01

Site-specific crop management or precision farming (PF) is a highly complex management system for site-specific input application of lime, fertilizers and pesticides in arable farming. The Global Positioning System (GPS) is the backbone of the system. To conduct PF several technical systems...

An innovative design of small low head hydropower units for low cost decentralized production

International Nuclear Information System (INIS)

Holmen, E.; Dennehy, T.

1991-01-01

Design allowing turbine operation at heads as low as 1m and operating at a rotational speed of 500 RPM at a flow of 2.6m 3 /s and a runner diameter of 700 mm. This eliminates the need for a gear box and helps in achieving efficiency of 60% in the case of a 21 kW installation at a 1m head site and 85% with a 69 kW 3.2m head site. Present turbine designs for such low head sites are very expensive to produce and have a low efficiency. The design uses an all plastic waterway, guide vane assembly and reinforced plastic runner blades. There will be a short pay-back period, for example 4.5 years in the case of a 21 kW unit and 2.0 years in case of the 69 kW unit. These payback periods assume a cost per kW of 0.00 ECU. Design is attractive for decentralized production. 3 figs

A preliminary design and BOP cost analysis of M-C Power`s MCFC commerical unit

Energy Technology Data Exchange (ETDEWEB)

Chen, T.P. [Bechtel Corp, San Francisco, CA (United States)

1996-12-31

M-C Power Corporation plans to introduce its molten carbonate fuel cell (MCFC) market entry unit in the year 2000 for distributed and on-site power generation. Extensive efforts have been made to analyze the cell stack manufacturing costs. The major objective of this study is to conduct a detailed analysis of BOP costs based on an initial design of the market entry unit.

NGA-West 2 GMPE average site coefficients for use in earthquake-resistant design

Science.gov (United States)

Borcherdt, Roger D.

2015-01-01

Site coefficients corresponding to those in tables 11.4–1 and 11.4–2 of Minimum Design Loads for Buildings and Other Structures published by the American Society of Civil Engineers (Standard ASCE/SEI 7-10) are derived from four of the Next Generation Attenuation West2 (NGA-W2) Ground-Motion Prediction Equations (GMPEs). The resulting coefficients are compared with those derived by other researchers and those derived from the NGA-West1 database. The derivation of the NGA-W2 average site coefficients provides a simple procedure to update site coefficients with each update in the Maximum Considered Earthquake Response MCER maps. The simple procedure yields average site coefficients consistent with those derived for site-specific design purposes. The NGA-W2 GMPEs provide simple scale factors to reduce conservatism in current simplified design procedures.

Use of the SSHAC methodology within regulated environments: Cost-effective application for seismic characterization at multiple sites

International Nuclear Information System (INIS)

Coppersmith, Kevin J.; Bommer, Julian J.

2012-01-01

Highlights: ► SSHAC processes provide high levels of regulatory assurance in hazard assessments for purposes of licensing and safety review. ► SSHAC projects provide structure to the evaluation of available data, models, and methods for building hazard input models. ► Experience on several nuclear projects in the past 15 years leads to the identification of key essential procedural steps. ► Conducting a regional SSHAC Level 3 study, followed by Level 2 site-specific studies can be time and cost effective. - Abstract: Essential elements of license applications and safety reviews for nuclear facilities are quantifications of earthquake and other natural hazards. A Senior Seismic Hazard Analysis Committee (SSHAC) Level 3 or 4 process provides regulatory assurance that the hazard assessment considers all data and models proposed by members of the technical community and the associated uncertainties have been properly quantified. The SSHAC process has been endorsed as an acceptable hazard assessment methodology in US NRC regulatory guidance. Where hazard studies are required for multiple sites, regional SSHAC Level 3 or 4 studies followed by site-specific Level 2 refinements can provide major benefits in cost and duration.

Status of small reactor designs without on-site refuelling

International Nuclear Information System (INIS)

2007-01-01

objectives of small reactors without on-site refuelling for a variety of uses, on the state of the art in technology development for such reactors, and on their design status. The report is intended for many categories of stakeholders, including electricity producers, non-electrical producers, policy makers, designers, and regulators. The main sections of this report, addressed to all above mentioned groups of stakeholders, survey emerging energy market characteristics and draw a rationale for small reactors without on-site refuelling; provide a summary and an assessment of major design specifications, applications and user-related special features for the surveyed reactor concepts; review the design status and targeted deployment dates; and outline the possible fuel cycle approaches. The annexes, intended mostly for designers and technical managers, provide detailed design descriptions of small reactors without on-site refuelling under development worldwide and are patterned along a common format, which makes it possible to identify the design philosophy, objectives and approaches, as well as technical features and non-technical factors and arrangements with a potential to provide solutions in the specific areas of concern associated with future nuclear energy systems. The scope of this report is limited to reactors without on-site refuelling, i.e. small reactors of less than 300 MW(e) effective output that are designed for infrequent replacement of well-contained fuel cassettes in a manner that impedes clandestine diversion of nuclear fuel material. SMRs with conventional refuelling schemes have been addressed in previous IAEA publications

Site-Specific Infrared Probes of Proteins

Science.gov (United States)

Ma, Jianqiang; Pazos, Ileana M.; Zhang, Wenkai; Culik, Robert M.; Gai, Feng

2015-01-01

Infrared spectroscopy has played an instrumental role in studying a wide variety of biological questions. However, in many cases it is impossible or difficult to rely on the intrinsic vibrational modes of biological molecules of interest, such as proteins, to reveal structural and/or environmental information in a site-specific manner. To overcome this limitation, many recent efforts have been dedicated to the development and application of various extrinsic vibrational probes that can be incorporated into biological molecules and used to site-specifically interrogate their structural and/or environmental properties. In this Review, we highlight some recent advancements of this rapidly growing research area. PMID:25580624

Cost-derived indices for building design and construction ...

African Journals Online (AJOL)

Also as multiples of gfi, substructure cost index, sci and roofing cost index, rci could predict componental costs of substructure and roofing for phased development purposes. Keywords: Cost Indices, Building Design, Building Construction Journal of Modeling, Design and Management of Engineering Systems, Vol.

Site-specific data confirm arsenic exposure predicted by the U.S. Environmental Protection Agency.

Science.gov (United States)

Walker, S; Griffin, S

1998-03-01

The EPA uses an exposure assessment model to estimate daily intake to chemicals of potential concern. At the Anaconda Superfund site in Montana, the EPA exposure assessment model was used to predict total and speciated urinary arsenic concentrations. Predicted concentrations were then compared to concentrations measured in children living near the site. When site-specific information on concentrations of arsenic in soil, interior dust, and diet, site-specific ingestion rates, and arsenic absorption rates were used, measured and predicted urinary arsenic concentrations were in reasonable agreement. The central tendency exposure assessment model successfully described the measured urinary arsenic concentration for the majority of children at the site. The reasonable maximum exposure assessment model successfully identified the uppermost exposed population. While the agreement between measured and predicted urinary arsenic is good, it is not exact. The variables that were identified which influenced agreement included soil and dust sample collection methodology, daily urinary volume, soil ingestion rate, and the ability to define the exposure unit. The concentration of arsenic in food affected agreement between measured and predicted total urinary arsenic, but was not considered when comparing measured and predicted speciated urinary arsenic. Speciated urinary arsenic is the recommended biomarker for recent inorganic arsenic exposure. By using site-specific data in the exposure assessment model, predicted risks from exposure to arsenic were less than predicted risks would have been if the EPA's default values had been used in the exposure assessment model. This difference resulted in reduced magnitude and cost of remediation while still protecting human health.

On cost-effective communication network designing

Science.gov (United States)

Zhang, Guo-Qiang

2010-02-01

How to efficiently design a communication network is a paramount task for network designing and engineering. It is, however, not a single objective optimization process as perceived by most previous researches, i.e., to maximize its transmission capacity, but a multi-objective optimization process, with lowering its cost to be another important objective. These two objectives are often contradictive in that optimizing one objective may deteriorate the other. After a deep investigation of the impact that network topology, node capability scheme and routing algorithm as well as their interplays have on the two objectives, this letter presents a systematic approach to achieve a cost-effective design by carefully choosing the three designing aspects. Only when routing algorithm and node capability scheme are elegantly chosen can BA-like scale-free networks have the potential of achieving good tradeoff between the two objectives. Random networks, on the other hand, have the built-in character for a cost-effective design, especially when other aspects cannot be determined beforehand.

Process Cost Modeling for Multi-Disciplinary Design Optimization

Science.gov (United States)

Bao, Han P.; Freeman, William (Technical Monitor)

2002-01-01

For early design concepts, the conventional approach to cost is normally some kind of parametric weight-based cost model. There is now ample evidence that this approach can be misleading and inaccurate. By the nature of its development, a parametric cost model requires historical data and is valid only if the new design is analogous to those for which the model was derived. Advanced aerospace vehicles have no historical production data and are nowhere near the vehicles of the past. Using an existing weight-based cost model would only lead to errors and distortions of the true production cost. This report outlines the development of a process-based cost model in which the physical elements of the vehicle are costed according to a first-order dynamics model. This theoretical cost model, first advocated by early work at MIT, has been expanded to cover the basic structures of an advanced aerospace vehicle. Elemental costs based on the geometry of the design can be summed up to provide an overall estimation of the total production cost for a design configuration. This capability to directly link any design configuration to realistic cost estimation is a key requirement for high payoff MDO problems. Another important consideration in this report is the handling of part or product complexity. Here the concept of cost modulus is introduced to take into account variability due to different materials, sizes, shapes, precision of fabrication, and equipment requirements. The most important implication of the development of the proposed process-based cost model is that different design configurations can now be quickly related to their cost estimates in a seamless calculation process easily implemented on any spreadsheet tool. In successive sections, the report addresses the issues of cost modeling as follows. First, an introduction is presented to provide the background for the research work. Next, a quick review of cost estimation techniques is made with the intention to

A Review of the Decommissioning Costs of the Ranstad Site

Energy Technology Data Exchange (ETDEWEB)

Varley, Geoff (NAC International, Norcross, GA (United States))

2009-08-15

The main objective of this study has been to review the future cost to decommission and dismantling the industrial area at the site of the old uranium mine at Ranstad in Sweden. Analyses of some detailed comparative empirical information have been used in the context of preliminary 'bench-marking' studies. The estimated costs for decommissioning of the old uranium mine in Ranstad have been compared with actual costs from other relevant decommissioning projects. In this way it has been possible to give a preliminary qualitative statement about the accuracy of the Ranstad cost estimate. The study gives the following lessons learned: 1. The available information suggests that the overall estimated cost may be reasonable, but there are still some points of weakness that need to be elaborated more in detail before a full statement about the adequacy of the forecast cost will be possible. 2. Especially the costs associated with declassification activities warrant further analysis in order to determine there level of accuracy. 3. There exists the possibility that the estimate might be low concerning decontamination, dismantling and planning and institutional work. 4. Further work and analysis is needed in order to develop a more transparent cost estimate in which the stakeholders can have the highest confidence. 5. A new bidding procedure for the conventional demolition may result in lower estimated costs. Hence, it would be beneficial to obtain an updated estimate based on at least more than one quotation. 6. The method of addressing uncertainty and risk should be more connected to the logistics of specific decommissioning activities, in order to be more transparent and clearer in details. There is a need for further study to develop a better estimate. In the short run follow-up work needs to be undertaken to provide a better understanding of what are the major contributors to risk and cost drivers in the planned decommissioning process at the Ranstad

A Review of the Decommissioning Costs of the Ranstad Site

International Nuclear Information System (INIS)

Varley, Geoff

2009-08-01

The main objective of this study has been to review the future cost to decommission and dismantling the industrial area at the site of the old uranium mine at Ranstad in Sweden. Analyses of some detailed comparative empirical information have been used in the context of preliminary 'bench-marking' studies. The estimated costs for decommissioning of the old uranium mine in Ranstad have been compared with actual costs from other relevant decommissioning projects. In this way it has been possible to give a preliminary qualitative statement about the accuracy of the Ranstad cost estimate. The study gives the following lessons learned: 1. The available information suggests that the overall estimated cost may be reasonable, but there are still some points of weakness that need to be elaborated more in detail before a full statement about the adequacy of the forecast cost will be possible. 2. Especially the costs associated with declassification activities warrant further analysis in order to determine there level of accuracy. 3. There exists the possibility that the estimate might be low concerning decontamination, dismantling and planning and institutional work. 4. Further work and analysis is needed in order to develop a more transparent cost estimate in which the stakeholders can have the highest confidence. 5. A new bidding procedure for the conventional demolition may result in lower estimated costs. Hence, it would be beneficial to obtain an updated estimate based on at least more than one quotation. 6. The method of addressing uncertainty and risk should be more connected to the logistics of specific decommissioning activities, in order to be more transparent and clearer in details. There is a need for further study to develop a better estimate. In the short run follow-up work needs to be undertaken to provide a better understanding of what are the major contributors to risk and cost drivers in the planned decommissioning process at the Ranstad industrial area

78 FR 14088 - Environmental Management Site-Specific Advisory Board, Savannah River Site

Science.gov (United States)

2013-03-04

...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act requires that public notice of this meeting be announced in the Federal Register.

Site-specific investigations of aquifer thermal energy storage for space and process cooling

International Nuclear Information System (INIS)

Brown, D.R.

1991-01-01

This paper reports on the Pacific Northwest Laboratory (PNL) that has completed three preliminary site-specific feasibility studies that investigated aquifer thermal energy storage (ATES) for reducing space and process cooling costs. Chilled water stored in an ATES system could be used to meet all or part of the process and/or space cooling loads at the three facilities investigated. Seasonal or diurnal chill ATES systems could be significantly less expensive than a conventional electrically-driven, load-following chiller system at one of the three sites, depending on the cooling water loop return temperature and presumed future electricity escalation rate. For the other two sites investigated, a chill ATES system would be economically competitive with conventional chillers if onsite aquifer characteristics were improved. Well flow rates at one of the sites were adequate, but the expected thermal recovery efficiency was too low. The reverse of this situation was found at the other site, where the thermal recovery efficiency was expected to be adequate, but well flow rates were too low

75 FR 65310 - Environmental Management Site-Specific Advisory Board, Nevada

Science.gov (United States)

2010-10-22

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Nevada Test Site. The Federal Advisory... Board is to make recommendations to DOE-EM and site management in the areas of environmental restoration...

Design of a photovoltaic central power station: flat-plate array

Energy Technology Data Exchange (ETDEWEB)

1984-02-01

A design for a photovoltaic central power station using fixed flat-panel arrays has been developed. The 100 MW plant is assumed to be located adjacent to the Saguaro Power Station of Arizona Public Service. The design assumes high-efficiency photovoltaic modules using dendritic web cells. The modules are arranged in 5 MW subfields, each with its own power conditioning unit. The photovoltaic output is connected to the existing 115 kV utility switchyard. The site specific design allows detailed cost estimates for engineering, site preparation, and installation. Collector and power conditioning costs have been treated parametrically.

Cost effectiveness of below-threshold waste disposal at DOE sites

International Nuclear Information System (INIS)

Wickham, L.E.; Smith, C.F.; Cohen, J.J.

1986-01-01

Previous study has indicated the feasibility of establishing a threshold of concentration below which certain low-level (radioactive wastes) (LLW) could be safely handled and disposed of by conventional means such as landfills. Such below-threshold wastes have been synonymously termed de minimis or below regulatory concern (BRC) and can be deemed appropriate for management according to their nonradiological characteristics. The objective of this study was to determine the cost effectiveness for management and disposal of below-threshold waste at certain US Department of Energy sites. The sites selected for this study were the Idaho National Engineering Laboratory and Savannah River Laboratory. Cost-benefit analysis was used to determine the impacts, benefits, and potential cost advantages of establishing and implementing a threshold limit

Large scale wind energy conversion system (WECS) design and installation as affected by site wind energy characteristics, grouping arrangement, and social acceptance. [Sweden

Energy Technology Data Exchange (ETDEWEB)

Ljungstrom, O

1977-01-01

The Swedish wind energy prospecting program includes special features of determining site wind characteristics and design of WECS group stations, which are described briefly, such as applications of normalized WDP-Wind Duration Profiles, WHP-Wind Height Profiles and how these are affected by site location and terrain roughness. A set of WEC-Wind Energy Classes (1 to 4) is introduced as an aid in territorial wind energy surveys. A survey of Sweden's WEPA-Wind Energy Producing Areas--with associated distribution over WEC-2-4 is presented. In order to determine the corresponding wind energy production capacity, the problem of optimizing WECS group station design for cost effective energy production per land usage must be solved. Here, the effects of WECS unit size and spacing on specific annual energy production, TWh/km/sup 2/, yr, are analyzed with the use of specific group station models in the 40 to 100 MW capacity range, applying WECS unit sizes 50kW, 1 MW and 5 MW, studying the energy balance for typical group stations. By applying the specific productivity data for 1 to 5 MW systems, a survey of the WEPA-associated wind energy production capacity in Sweden is presented.

FLP recombinase-mediated site-specific recombination in silkworm, Bombyx mori.

Directory of Open Access Journals (Sweden)

Ding-Pei Long

Full Text Available A comprehensive understanding of gene function and the production of site-specific genetically modified mutants are two major goals of genetic engineering in the post-genomic era. Although site-specific recombination systems have been powerful tools for genome manipulation of many organisms, they have not yet been established for use in the manipulation of the silkworm Bombyx mori genome. In this study, we achieved site-specific excision of a target gene at predefined chromosomal sites in the silkworm using a FLP/FRT site-specific recombination system. We first constructed two stable transgenic target silkworm strains that both contain a single copy of the transgene construct comprising a target gene expression cassette flanked by FRT sites. Using pre-blastoderm microinjection of a FLP recombinase helper expression vector, 32 G3 site-specific recombinant transgenic individuals were isolated from five of 143 broods. The average frequency of FLP recombinase-mediated site-specific excision in the two target strains genome was approximately 3.5%. This study shows that it is feasible to achieve site-specific recombination in silkworms using the FLP/FRT system. We conclude that the FLP/FRT system is a useful tool for genome manipulation in the silkworm. Furthermore, this is the first reported use of the FLP/FRT system for the genetic manipulation of a lepidopteran genome and thus provides a useful reference for the establishment of genome manipulation technologies in other lepidopteran species.

Specialty-specific admission: a cost-effective intervention?

LENUS (Irish Health Repository)

Slattery, E

2012-02-01

INTRODUCTION: Cost effectiveness of healthcare has become an important component in its delivery. Current practices need to be assessed and measured for variations that may lead to financial savings. Speciality specific admission is known not only to lead improved clinical outcomes but also to lead important cost reductions. METHODS: All patients admitted to an Irish teaching hospital via the emergency department over a 2-year period with a gastroenterology (GI) related illness were included in this analysis.GI illness was classified using the Disease related grouping (DRG) system. Mean length of stay (LOS) and patient level costing (PLC) were calculated. Differences between DRGs with respect to speciality (i.e. specialist vs. non-specialist) were calculated for the five commonest DRGs. RESULTS: Significant variations in LOS and PLC were demonstrated in the DRGs. Mean LOS varied with increasing complexity, from 3.2 days for non-complex GI haemorrhage to 14.4 days for complex alcohol related cirrhosis as expected. A substantial difference in LOS within DRG groups was demonstrated by large standard deviations in the mean (up to 8.1 days in some groups) and was independent of complexity of cases. PLC also varied widely in both complex and non-complex cases with standard deviations of up to 17,342 noted. Specialty-specific admission was associated with shorter LOS for most GI admissions. CONCLUSION: Significant disparity exists for both LOS and PLC for most GI diagnoses. Specialty-specific admissions are associated with reduced LOS. Specialty-specific admission would appear to be cost-effective which may also lead to improved clinical outcomes.

A generic tool for cost estimating in aircraft design

NARCIS (Netherlands)

Castagne, S.; Curran, R.; Rothwell, A.; Price, M.; Benard, E.; Raghunathan, S.

2008-01-01

A methodology to estimate the cost implications of design decisions by integrating cost as a design parameter at an early design stage is presented. The model is developed on a hierarchical basis, the manufacturing cost of aircraft fuselage panels being analysed in this paper. The manufacturing cost

Design of cost effective antennas for instrumentation radars

CSIR Research Space (South Africa)

Botha, L

2012-09-01

Full Text Available The cost of antennas for instrumentation radars are determined by the development cost. By re-use of the reflector system cost effective antennas can be designed. The factors governing the design of such antennas are described here....

78 FR 26005 - Environmental Management Site-Specific Advisory Board, Savannah River Site

Science.gov (United States)

2013-05-03

...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

78 FR 65979 - Environmental Management Site-Specific Advisory Board, Savannah River Site

Science.gov (United States)

2013-11-04

...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

77 FR 24695 - Environmental Management Site-Specific Advisory Board, Savannah River Site

Science.gov (United States)

2012-04-25

...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. . 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

77 FR 60688 - Environmental Management Site-Specific Advisory Board, Savannah River Site

Science.gov (United States)

2012-10-04

...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

77 FR 13104 - Environmental Management Site-Specific Advisory Board, Savannah River Site

Science.gov (United States)

2012-03-05

...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

77 FR 39235 - Environmental Management Site-Specific Advisory Board, Savannah River Site

Science.gov (United States)

2012-07-02

...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

78 FR 716 - Environmental Management Site-Specific Advisory Board, Savannah River Site

Science.gov (United States)

2013-01-04

...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

78 FR 54461 - Environmental Management Site-Specific Advisory Board, Savannah River Site

Science.gov (United States)

2013-09-04

...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

77 FR 53193 - Environmental Management Site-Specific Advisory Board, Savannah River Site

Science.gov (United States)

2012-08-31

...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

Low Cost High Performance Generator Technology Program. Volume 2. Design study

International Nuclear Information System (INIS)

1975-06-01

The systems studies directed towards up-rating the performance of an RTG using selenide thermoelectrics and a heat source with improved safety are reported. The resulting generator design, designated LCHPG, exhibits conversion efficiency of greater than 10 percent, a specific power of 3 W/lb., and a cost of $6,000/W(e). In the course of system analyses, the significant development activities required to achieve this performance by the 1980 time period are identified

78 FR 40130 - Environmental Management Site-Specific Advisory Board, Savannah River Site

Science.gov (United States)

2013-07-03

...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. No. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

78 FR 16260 - Environmental Management Site-Specific Advisory Board, Savannah River Site

Science.gov (United States)

2013-03-14

...On March 4, 2013, the Department of Energy (DOE) published a notice of open meeting announcing a meeting on March 25-26, 2013 of the Environmental Management Site-Specific Advisory Board, Savannah River Site (78 FR 14088). This document makes a correction to that notice.

Design Optimization and Site Matching of Direct-Drive Permanent Magnet Wind Generator Systems

DEFF Research Database (Denmark)

Li, H.; Chen, Zhe

2009-01-01

This paper investigates the possible site matching of the direct-drive wind turbine concepts based on the electromagnetic design optimization of permanent magnet (PM) generator systems. Firstly, the analytical models of a three-phase radial-flux PM generator with a back-to-back power converter...... of the maximum wind energy capture, the rotor diameter and the rated wind speed of a direct-drive wind turbine with the optimum PM generator are determined. The annual energy output (AEO) is also presented using the Weibull density function. Finally, the maximum AEO per cost (AEOPC) of the optimized wind...... are presented. The optimum design models of direct-drive PM wind generation system are developed with an improved genetic algorithm, and a 500-kW direct-drive PM generator for the minimal generator active material cost is compared to demonstrate the effectiveness of the design optimization. Forty-five PM...

75 FR 6018 - Environmental Management Site-Specific Advisory Board, Hanford

Science.gov (United States)

2010-02-05

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Hanford AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Hanford (known locally as the Hanford Advisory... and site management in the areas of environmental restoration, waste management, and related...

Using network screening methods to determine locations with specific safety issues: A design consistency case study.

Science.gov (United States)

Butsick, Andrew J; Wood, Jonathan S; Jovanis, Paul P

2017-09-01

The Highway Safety Manual provides multiple methods that can be used to identify sites with promise (SWiPs) for safety improvement. However, most of these methods cannot be used to identify sites with specific problems. Furthermore, given that infrastructure funding is often specified for use related to specific problems/programs, a method for identifying SWiPs related to those programs would be very useful. This research establishes a method for Identifying SWiPs with specific issues. This is accomplished using two safety performance functions (SPFs). This method is applied to identifying SWiPs with geometric design consistency issues. Mixed effects negative binomial regression was used to develop two SPFs using 5 years of crash data and over 8754km of two-lane rural roadway. The first SPF contained typical roadway elements while the second contained additional geometric design consistency parameters. After empirical Bayes adjustments, sites with promise (SWiPs) were identified. The disparity between SWiPs identified by the two SPFs was evident; 40 unique sites were identified by each model out of the top 220 segments. By comparing sites across the two models, candidate road segments can be identified where a lack design consistency may be contributing to an increase in expected crashes. Practitioners can use this method to more effectively identify roadway segments suffering from reduced safety performance due to geometric design inconsistency, with detailed engineering studies of identified sites required to confirm the initial assessment. Copyright © 2017 Elsevier Ltd. All rights reserved.

76 FR 5147 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2011-01-28

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

77 FR 59598 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2012-09-28

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

75 FR 13269 - Environmental Management Site-Specific Advisory Board, Hanford

Science.gov (United States)

2010-03-19

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Hanford AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Hanford. The Federal Advisory Committee Act... is to make recommendations to DOE-EM and site management in the areas of environmental restoration...

75 FR 54600 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2010-09-08

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

75 FR 66074 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2010-10-27

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

75 FR 8050 - Environmental Management Site-Specific Advisory Board, Hanford

Science.gov (United States)

2010-02-23

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Hanford AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Hanford. The Federal Advisory Committee Act... is to make recommendations to DOE-EM and site management in the areas of environmental restoration...

75 FR 24686 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2010-05-05

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

76 FR 80355 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2011-12-23

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... make recommendations to DOE-EM and site management in the areas of environmental restoration, waste...

75 FR 9404 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2010-03-02

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

75 FR 56526 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2010-09-16

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Initiative Workshop of the Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

77 FR 43583 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2012-07-25

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

75 FR 61711 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2010-10-06

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

75 FR 82002 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2010-12-29

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

76 FR 61350 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2011-10-04

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... make recommendations to DOE-EM and site management in the areas of environmental restoration, waste...

76 FR 4645 - Environmental Management Site-Specific Advisory Board, Hanford

Science.gov (United States)

2011-01-26

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Hanford AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Hanford. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management, and...

76 FR 48148 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2011-08-08

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

Preliminary conceptual design and cost estimation for Korea Advanced Pyroprocessing Facility Plus (KAPF+)

Energy Technology Data Exchange (ETDEWEB)

Ko, Won Il, E-mail: nwiko@kaeri.re.kr [Korea Atomic Energy Research Institute, 989-111, Daedeok-daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Lee, Ho Hee, E-mail: nhhlee@kaeri.re.kr [Korea Atomic Energy Research Institute, 989-111, Daedeok-daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Choi, Sungyeol, E-mail: csy@kaeri.re.kr [Korea Atomic Energy Research Institute, 989-111, Daedeok-daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Kim, Sung-Ki, E-mail: sgkim1@kaeri.re.kr [Korea Atomic Energy Research Institute, 989-111, Daedeok-daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Park, Byung Heung, E-mail: b.h.park@ut.ac.kr [Department of Chemical and Biological Engineering, Korea National University of Transportation, 50 Daehak-ro, Chungju-si, Chungbuk, 380-702 (Korea, Republic of); Lee, Hyo Jik, E-mail: hyojik@kaeri.re.kr [Korea Atomic Energy Research Institute, 989-111, Daedeok-daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Kim, In Tae, E-mail: nitkim@kaeri.re.kr [Department of Chemical and Biological Engineering, Korea National University of Transportation, 50 Daehak-ro, Chungju-si, Chungbuk, 380-702 (Korea, Republic of); Lee, Han Soo, E-mail: hslee5@kaeri.re.kr [Korea Atomic Energy Research Institute, 989-111, Daedeok-daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of)

2014-10-01

Highlights: • Conceptual design is created for a pilot pyroprocessing plant treating PWR spent fuel. • Pilot-scale design is based on a capacity of 400 tHM/yr with 60 years lifetime. • All individual processes are integrated into a single system from feed to products. • Overall facility design is developed for a pilot pyroprocessing plant. • Unit process cost is estimated for pyroprocessing with uncertainties. - Abstract: Korea has developed pyroprocessing technology as a potential option for recycling spent fuels (SFs) from pressurized water reactors (PWRs). The pyroprocessing consists of various key unit processes and a number of research activities have been focused on each process. However, to realize the whole pyroprocessing concept, there is a critical need for integrating the individual developments and addressing a material flow from feed to final products. In addition, the advancement on overall facility design is an indispensable aspect for demonstration and commercialization of the pyroprocessing. In this study, a facility named as Korea Advanced Pyroprocess Facility Plus (KAPF+) is conceptualized with a capacity of 400 tHM/yr. The process steps are categorized based on their own characteristics while the capacities of process equipment are determined based on the current technical levels. The facility concept with a site layout of 104,000 m{sup 2} is developed by analyzing the operation conditions and materials treated in each process. As an economic approach to the proposed facility, the unit cost (781 $/kgHM denominated in 2009 USD) for KAPF+ is also analyzed with the conceptual design with preliminary sensitivity assessments including decontamination and decommissioning costs, a discount rate, staffing costs, and plant lifetime. While classifying and describing cost details of KAPF+, this study compares the unit cost of KAPF+ treating PWR SF to that of the pyroprocessing facility treating sodium-cooled fast reactor (SFR) SF.

Y-12 site-specific earthquake response analysis and soil liquefaction assessment

International Nuclear Information System (INIS)

Ahmed, S.B.; Hunt, R.J.; Manrod, W.E. III.

1995-01-01

A site-specific earthquake response analysis and soil liquefaction assessment were performed for the Oak Ridge Y-12 Plant. The main purpose of these studies was to use the results of the analyses for evaluating the safety of the performance category -1, -2, and -3 facilities against the natural phenomena seismic hazards. Earthquake response was determined for seven (7), one dimensional soil columns (Fig. 12) using two horizontal components of the PC-3 design basis 2000-year seismic event. The computer program SHAKE 91 (Ref. 7) was used to calculate the absolute response accelerations on top of ground (soil/weathered shale) and rock outcrop. The SHAKE program has been validated for horizontal response calculations at periods less than 2.0 second at several sites and consequently is widely accepted in the geotechnical earthquake engineering area for site response analysis

Cultivating Collaborations: Site Specific Design for Embodied Science Learning.

Science.gov (United States)

Gill, Katherine; Glazier, Jocelyn; Towns, Betsy

2018-05-21

Immersion in well-designed outdoor environments can foster the habits of mind that enable critical and authentic scientific questions to take root in students' minds. Here we share two design cases in which careful, collaborative, and intentional design of outdoor learning environments for informal inquiry provide people of all ages with embodied opportunities to learn about the natural world, developing the capacity for understanding ecology and the ability to empathize, problem-solve and reflect. Embodied learning, as facilitated by and in well-designed outdoor learning environments, leads students to develop new ways of seeing, new scientific questions, new ways to connect with ideas, with others and new ways of thinking about the natural world. Using examples from our collaborative practices as experiential learning designers, we illustrate how creating the habits of mind critical to creating scientists, science-interested, and science-aware individuals benefits from providing students spaces to engage in embodied learning in nature. We show how public landscapes designed in creative partnerships between educators, scientists, designers and the public have potential to amplify science learning for all.

Quantum mechanical design of enzyme active sites.

Science.gov (United States)

Zhang, Xiyun; DeChancie, Jason; Gunaydin, Hakan; Chowdry, Arnab B; Clemente, Fernando R; Smith, Adam J T; Handel, T M; Houk, K N

2008-02-01

The design of active sites has been carried out using quantum mechanical calculations to predict the rate-determining transition state of a desired reaction in presence of the optimal arrangement of catalytic functional groups (theozyme). Eleven versatile reaction targets were chosen, including hydrolysis, dehydration, isomerization, aldol, and Diels-Alder reactions. For each of the targets, the predicted mechanism and the rate-determining transition state (TS) of the uncatalyzed reaction in water is presented. For the rate-determining TS, a catalytic site was designed using naturalistic catalytic units followed by an estimation of the rate acceleration provided by a reoptimization of the catalytic site. Finally, the geometries of the sites were compared to the X-ray structures of related natural enzymes. Recent advances in computational algorithms and power, coupled with successes in computational protein design, have provided a powerful context for undertaking such an endeavor. We propose that theozymes are excellent candidates to serve as the active site models for design processes.

75 FR 82004 - Environmental Management Site-Specific Advisory Board, Nevada

Science.gov (United States)

2010-12-29

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Nevada. The Federal Advisory Committee Act (Pub... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management, and...

77 FR 4027 - Environmental Management Site-Specific Advisory Board, Nevada

Science.gov (United States)

2012-01-26

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Nevada. The Federal Advisory Committee Act (Pub... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management, and...

76 FR 80354 - Environmental Management Site-Specific Advisory Board, Nevada

Science.gov (United States)

2011-12-23

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Nevada. The Federal Advisory Committee Act (Pub... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management, and...

77 FR 12044 - Environmental Management Site-Specific Advisory Board, Nevada

Science.gov (United States)

2012-02-28

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Nevada. The Federal Advisory Committee Act (Pub... Board is to make recommendations to DOE-EM and site management in the areas of environmental restoration...

Design features and cost reduction potential of JSFR

International Nuclear Information System (INIS)

Katoh, Atsushi; Hayafune, Hiroki; Kotake, Shoji

2014-01-01

Highlights: • Japan Sodium Cooled Fast Reactor (JSFR) is designed to reduce plant commodity. • Cost reduction effectiveness by innovative designs is estimated by bottom up method. • JSFR achieves 76% construction cost reduction compared with Monju by design effort. • Commercial JSFR construction cost could be less than that of conventional LWR. - Abstract: To improve the economic competitiveness of the Japan Sodium-cooled Fast Reactor (JSFR), several innovative designs have been introduced, e.g. reduction of number of main cooling loop, shorter pipe arrangement by adopting thermally durable material, in fact high chromium ferrite steel, a compact reactor vessel (RV), integration of a primary pump and an intermediate heat exchanger (IHX). Since they had not been introduced in the past and existing reactors, a new approach for construction cost estimation has been introduced to handle innovative technologies, for example, concerning different kinds of material, fabrication processes of equipment etc. As results of JSFR construction cost estimations based on the new method and the latest conceptual JSFR design, economic goals of Generation IV nuclear energy systems can be achieved by expecting the following cost reduction effects: commodity reduction by adopting innovative design, an economy of scale by power generation increase, learning effect etc. It is well analyzed quantitatively that feasibility of innovative designs is essential for economic competitiveness of JSFR

Design features and cost reduction potential of JSFR

Energy Technology Data Exchange (ETDEWEB)

Katoh, Atsushi, E-mail: kato.atsushi@jaea.go.jp [Japan Atomic Energy Agency, 4002 Narita, Oarai-machi, Higashi-ibaraki-gun, Ibaraki-ken 311-1393 (Japan); Hayafune, Hiroki [Japan Atomic Energy Agency, 4002 Narita, Oarai-machi, Higashi-ibaraki-gun, Ibaraki-ken 311-1393 (Japan); Kotake, Shoji [The Japan Atomic Power Company, 1-1 Kanda-midoricyo, Chiyoda-ku, Tokyo-to 101-0053 (Japan)

2014-12-15

Highlights: • Japan Sodium Cooled Fast Reactor (JSFR) is designed to reduce plant commodity. • Cost reduction effectiveness by innovative designs is estimated by bottom up method. • JSFR achieves 76% construction cost reduction compared with Monju by design effort. • Commercial JSFR construction cost could be less than that of conventional LWR. - Abstract: To improve the economic competitiveness of the Japan Sodium-cooled Fast Reactor (JSFR), several innovative designs have been introduced, e.g. reduction of number of main cooling loop, shorter pipe arrangement by adopting thermally durable material, in fact high chromium ferrite steel, a compact reactor vessel (RV), integration of a primary pump and an intermediate heat exchanger (IHX). Since they had not been introduced in the past and existing reactors, a new approach for construction cost estimation has been introduced to handle innovative technologies, for example, concerning different kinds of material, fabrication processes of equipment etc. As results of JSFR construction cost estimations based on the new method and the latest conceptual JSFR design, economic goals of Generation IV nuclear energy systems can be achieved by expecting the following cost reduction effects: commodity reduction by adopting innovative design, an economy of scale by power generation increase, learning effect etc. It is well analyzed quantitatively that feasibility of innovative designs is essential for economic competitiveness of JSFR.

Site-specific waste management instruction for the field sampling organization

International Nuclear Information System (INIS)

Bryant, D.L.

1997-01-01

The Site-Specific Waste Management Instruction (SSWMI) provides guidance for the management of waste generated from field-sampling activities performed by the Environment Restoration Contractor (ERC) Sampling Organization that are not managed as part of a project SSWMI. Generally, the waste is unused preserved groundwater trip blanks, used and expired calibration solutions, and other similar waste that cannot be returned to an ERC project for disposal. The specific waste streams addressed by this SSWMI are identified in Section 2.0. This SSWMI was prepared in accordance with BHI-EE-02, Environmental Requirements. Waste generated from field sample collection activities should be returned to the project and managed in accordance with the applicable project-specific SSWMI whenever possible. However, returning all field sample collection and associated waste to a project for disposal may not always be practical or cost effective. Therefore, the ERC field sampling organization must manage and arrange to dispose of the waste using the (Bechtel Hanford, Inc. [BHI]) Field Support Waste Management (FSWM) services. This SSWMI addresses those waste streams that are the responsibility of the field sampling organization to manage and make arrangements for disposal

PHWR safety: design, siting and construction

International Nuclear Information System (INIS)

Sharma, V.K.

2002-01-01

In all activities associated with NPPs viz. siting, design, construction, commissioning and operation, safety is given overriding importance. The safety design principles of PHWRs are based on defence-in-depth approach, physical and functional separation between process and safety systems and also among various safety systems, redundancy to meet single failure criteria and postulation of a number of design basis events for which the plant must be designed. Apart from engineered safety systems, PHWRs have inherent characteristics which contribute to safety. In siting of a NPP, it is required to ensure that the given site does not pose undue radiological hazard to public and the environment both during normal operation as well as during and following an accident condition. For this purpose, all site related external events, both natural and man induced, are assessed for their effect on the plant and are considered as part of the design basis. Possible radiological impact of the NPP on environment and surrounding population is assessed and ensured to be within acceptable limits. During construction phase, it is essential that the NPP be built in accordance with design intent and with required quality of workmanship to ensure that the NPP will remain safe during all states of operation. This is achieved through careful execution and QA activities encompassing all aspects of component fabrication at manufacturer works, civil construction, site erection, assembly, and commissioning. Future trends in nuclear safety will continue to be based on existing principles which have proved to be sound. These will be further strengthened by features such as increasing use of passive means of performing safety functions and a more explicit treatment of severe accidents. (author)

Reclamation of oil and gas well sites on privately-owned land in Alberta: An evaluation of benefits and costs

International Nuclear Information System (INIS)

Bates, L.A.

1994-01-01

In Alberta, ca 24,000 oil/gas well sites will be abandoned over the next 10 years. There is concern that the expense to reclaim the surface lands at these sites to current standards represents a substantial opportunity cost to industry and the provincial economy. The economic costs and benefits associated with regulation of such reclamation activity are examined and the impacts of surface access regulations on the reclamation process are discussed. Cost benefit analysis is not easily applied to environmental regulation where some extra-market benefits and costs are intangible and/or unmeasurable. Although this qualifies the results, it appears that the costs of wellsite reclamation exceed the benefits. Costs are defined as reclamation expenses; benefits are defined as the real estate value of the land, or the net present value of agricultural land rentals. An effort has been made to provide a proxy for the extra-market value of the land to the landowner. The continuation of full surface access compensation for nonproducing wells can result in negative incentive effects that reduce allocative efficiency of reclamation regulation. Reclamation costs are correlated with well age and surface access payments, but not with agricultural land use or geographic region. This suggests that reclamation standards designed to reclaim well sites to the same productive capacity as site-adjacent land is not driving reclamation effort. Rather, landowners have negotiated substantial annual surface lease payments and may also be demanding greater reclamation effort, either to maximize compensation due to higher expectations. Methods of reducing these negative incentive effects to better achieve reclamation goals are suggested. 49 refs., 9 figs., 17 tabs

Site-Specific Research Conducted in Support of the Salton Sea Solar Pond Project - FY 1982 Report

Science.gov (United States)

French, R. L.; Marsh, H. E.; Roschke, E. J.; Wu, Y. C.

1984-01-01

The design and operation of a salt-gradient solar pond power plant at the Salton Sea presents problems not encountered at small research ponds that were built in the United States. The specific characteristics of the Salton Sea site and the desire to construct the pond using the local clay as a sealant represent major deviations from previous solar pond experience. The site-specific research in support of the plant design is described. The research activity included validation of the spectrophotometric light transmission measurement technique, a search for options for clarifying the turbid and colored water of the Salton Sea, development of water clarification specifications in terms common to industry practice, quantification of gas production from microbiological reactions in the ground, a determination of the combined effects of temperature and salinity on the permeation of the local clays, and a preliminary evaluation of material corrosion.

Solar energy for process heat: Design/cost studies of four industrial retrofit applications

Science.gov (United States)

French, R. L.; Bartera, R. E.

1978-01-01

Five specific California plants with potentially attractive solar applications were identified in a process heat survey. These five plants were visited, process requirements evaluated, and conceptual solar system designs were generated. Four DOE (ERDA) sponsored solar energy system demonstration projects were also reviewed and compared to the design/cost cases included in this report. In four of the five cases investigated, retrofit installations providing significant amounts of thermal energy were found to be feasible. The fifth was rejected because of the condition of the building involved, but the process (soap making) appears to be an attractive potential solar application. Costs, however, tend to be high. Several potential areas for cost reduction were identified including larger collector modules and higher duty cycles.

Site-Specific Waste Management Instruction - 100-DR-1 Group 2 Sites

International Nuclear Information System (INIS)

Jackson, R.W.

1998-01-01

This site-specific waste management instruction (SSWMI) provides guidance for the management of wastes that may be generated during the excavation and remediation of the 100-DR-1 Group 2 sites. The management of waste generated as a result of these activities will be as directed in this SSWMI. This SSWMI will be revised to incorporate guidance for management of wastes encountered that are not addressed in this SSWMI

Molecular design of sequence specific DNA alkylating agents.

Science.gov (United States)

Minoshima, Masafumi; Bando, Toshikazu; Shinohara, Ken-ichi; Sugiyama, Hiroshi

2009-01-01

Sequence-specific DNA alkylating agents have great interest for novel approach to cancer chemotherapy. We designed the conjugates between pyrrole (Py)-imidazole (Im) polyamides and DNA alkylating chlorambucil moiety possessing at different positions. The sequence-specific DNA alkylation by conjugates was investigated by using high-resolution denaturing polyacrylamide gel electrophoresis (PAGE). The results showed that polyamide chlorambucil conjugates alkylate DNA at flanking adenines in recognition sequences of Py-Im polyamides, however, the reactivities and alkylation sites were influenced by the positions of conjugation. In addition, we synthesized conjugate between Py-Im polyamide and another alkylating agent, 1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI). DNA alkylation reactivies by both alkylating polyamides were almost comparable. In contrast, cytotoxicities against cell lines differed greatly. These comparative studies would promote development of appropriate sequence-specific DNA alkylating polyamides against specific cancer cells.

Techniques for Conducting Effective Concept Design and Design-to-Cost Trade Studies

Science.gov (United States)

Di Pietro, David A.

2015-01-01

Concept design plays a central role in project success as its product effectively locks the majority of system life cycle cost. Such extraordinary leverage presents a business case for conducting concept design in a credible fashion, particularly for first-of-a-kind systems that advance the state of the art and that have high design uncertainty. A key challenge, however, is to know when credible design convergence has been achieved in such systems. Using a space system example, this paper characterizes the level of convergence needed for concept design in the context of technical and programmatic resource margins available in preliminary design and highlights the importance of design and cost evaluation learning curves in determining credible convergence. It also provides techniques for selecting trade study cases that promote objective concept evaluation, help reveal unknowns, and expedite convergence within the trade space and conveys general practices for conducting effective concept design-to-cost studies.

Remedial design services for Montclair/West Orange and Glen Ridge Superfund sites

International Nuclear Information System (INIS)

Urbaniak, T.F.; Tomiczek, P.W. Jr.

1994-01-01

The Montclair/West Orange and Glen Ridge Superfund Sites are located 12 miles west of New York City in Essex County, New Jersey. The sites are contaminated with waste materials from radium-processing facilities which operated in the area during the early 1900's. The waste materials, containing radium and other radioactive isotopes were placed in three separate landfill sites. Major public health risks are indoor radon gas build-up and indoor/ outdoor gamma radiation. In 1989, the EPA issued a Record of Decision (ROD) which chose excavation and off-site disposal of material as the preferred alternative. The purpose of this presentation is to highlight key elements of the design process for the remedial action at Montclair. Those key elements are as follows: meeting community relations challenges; measuring radioactive contamination; developing plans and specifications; packaging of remedial action contacts; and continually improving both the process and the designs

Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites.

Science.gov (United States)

Zelanis, André; Huesgen, Pitter F; Oliveira, Ana Karina; Tashima, Alexandre K; Serrano, Solange M T; Overall, Christopher M

2015-01-15

Many snake venom toxins are serine proteases but their specific in vivo targets are mostly unknown. Various act on components of the coagulation cascade, and fibrinolytic and kallikrein-kinin systems to trigger various pathological effects observed in the envenomation. Despite showing high similarity in terms of primary structure snake venom serine proteinases (SVSPs) show exquisite specificity towards macromolecular substrates. Therefore, the characterization of their peptide bond specificity is important for understanding the active site preference associated with effective proteolysis as well as for the design of peptide substrates and inhibitors. Bothrops jararaca contains various SVSPs among which Bothrops protease A is a specific fibrinogenolytic agent and PA-BJ is a platelet-activating enzyme. In this study we used proteome derived peptide libraries in the Proteomic Identification of protease Cleavage Sites (PICS) approach to explore the peptide bond specificity of Bothrops protease A and PA-BJ in order to determine their individual peptide cleavage sequences. A total of 371 cleavage sites (208 for Bothrops protease A and 163 for PA-BJ) were detected and both proteinases displayed a clear preference for arginine at the P1 position. Moreover, the analysis of the specificity profiles of Bothrops protease A and PA-BJ revealed subtle differences in the preferences along P6-P6', despite a common yet unusual preference for Pro at P2. Taken together, these results map the subsite specificity of both SVSPs and shed light in the functional differences between these proteinases. Proteolysis is key to various pathological effects observed upon envenomation by viperid snakes. The use of the Proteomic Identification of protease Cleavage Sites (PICS) approach for the easy mapping of proteinase subsite preferences at both the prime- and non-prime sides concurrently gives rise to a fresh understanding of the interaction of the snake venom serine proteinases with peptide and

Site-specific design of the super collider in Texas

International Nuclear Information System (INIS)

Laughton, C.; Nelson, P.P.; Lundin, T.K.

1990-01-01

This paper outlines the scope of the Superconducting Super Collider (SSC) in Texas, underground works and present the current accelerator layout. After a brief overview of the site geotechnical characteristics, emphasis will be placed upon the possibilities for the incorporation of mechanical excavation technology into the construction of the various underground structures

Site-specific design of the super collider in Texas

International Nuclear Information System (INIS)

Laughton, C.; Nelson, P.P.; Lundin, T.K.

1990-06-01

This paper will outline the scope of the Superconducting Super Collider (SSC), underground works and present the current accelerator layout. After a brief overview of the site geotechnical characteristics, emphasis will be placed upon the possibilities for the incorporation of mechanical excavation technology into the construction of the various underground structures. 5 figs

Linkage between site characterization program and performance and design data needs

International Nuclear Information System (INIS)

Blanchard, M.B.; Dobson, D.C.; Younker, J.L.; Voegele, M.D.

1990-01-01

The basis for identifying site-specific data needs for the Yucca Mountain site was a thorough review and evaluation of the regulatory requirements for a geologic repository. The US Nuclear Regulatory Commission's (NRC) regulation governing disposal of high-level waste in a geologic repository utilizes a multiple barrier approach that includes reliance on both engineered and natural elements. Given an understanding of the regulatory requirements, the next step was to identify the natural features of the site and the components of the engineered barriers considered most likely to make significant contributions to isolation of waste at Yucca Mountain. The intent was to develop a site testing program that focused on understanding those natural site characteristics and processes most likely to contribute to waste isolation; and providing site data necessary to design and assess the performance of engineered barriers. 3 refs., 3 figs

Cost reductions on a site producing soap and detergents

Energy Technology Data Exchange (ETDEWEB)

Clayton, R.W. (UKAEA Harwell Lab. (UK). Energy Technology Div.)

1986-05-01

The company, which is a subsidiary of the multinational Procter and Gamble Company, manufactures soap and detergent products at two UK sites. A process integration study of the West Thurrock site was undertaken with the help of the Energy and Process Integration Service (EPI). This organisation offers a specialist process integration consultancy service. The study cost around Pound 45,000, including consultancy fees and Procter and Gamble staff time. It was completed in 12 months. The study established that the consumption of process energy could be reduced by around 25% if the site was fully integrated. (author).

Optimal Cost-Analysis and Design of Circular Footings

Directory of Open Access Journals (Sweden)

Prabir K. Basudhar

2012-10-01

Full Text Available The study pertains to the optimal cost-analysis and design of a circular footing subjected to generalized loadings using sequential unconstrained minimization technique (SUMT in conjunction with Powell’s conjugate direction method for multidimensional search and quadratic interpolation method for one dimensional minimization. The cost of the footing is minimized satisfying all the structural and geotechnical engineering design considerations. As extended penalty function method has been used to convert the constrained problem into an unconstrained one, the developed technique is capable of handling both feasible and infeasible initial design vector. The net saving in cost starting from the best possible manual design ranges from 10 to 20 %. For all practical purposes, the optimum cost is independent of the initial design point. It was observed that for better convergence, the transition parameter  should be chosen at least 100 times the initial penalty parameter kr .

Optimal cost design of base-isolated pool structures for the storage of nuclear spent fuel

International Nuclear Information System (INIS)

Ko, H. M.; Park, K. S.; Song, J. H.

1999-01-01

A method of cost-effectiveness evaluation for seismic isolated pool structures is presented. Input ground motion is modeled as spectral density function compatible with response spectrum for combination of acceleration coefficient and site coefficient. Interaction effects between flexible walls and contained fluid are considered in the form of added mass matrix. Wall thickness and isolator stiffness are adopted as design variables for optimization. Transfer function vector of the structure-isolator system is derived from the equation of motion. Spectral analysis method based on random vibration theories is used for the calculation of failure probability. The exemplifying designs and analyses show that cost-effectiveness of isolated pool structure is relatively high in low-moderate seismic region and stiff soil condition. Sensitiveness of optimal design variables to assumed damage scales is relatively low in such region

Risk management study for the Hanford Site facilities: Risk reduction cost comparison for the retired Hanford Site facilities

International Nuclear Information System (INIS)

Coles, G.A.; Egge, R.G.; Senger, E.; Shultz, M.W.; Taylor, W.E.

1994-02-01

This document provides a cost-comparison evaluation for implementing certain risk-reduction measures and their effect on the overall risk of the 100 and 200 Area retired, surplus facilities. The evaluation is based on conditions that existed at the time the risk evaluation team performed facility investigations, and does not acknowledge risk-reduction measures that occurred soon after risk identification. This evaluation is one part of an overall risk management study for these facilities. The retired facilities investigated for this evaluation are located in the 100 and 200 Areas of the 1450-km 2 Hanford Site. The Hanford Site is a semiarid tract of land in southeastern Washington State. The nearest population center is Richland, Washington, (population 32,000) 30 km southeast of the 200 Area. This cost-comparison evaluation (1) determines relative costs for reducing risk to acceptable levels; (2) compares the cost of reducing risk using different risk-reduction options; and (3) compares the cost of reducing risks at different facilities. The result is an identification of the cost effective risk-reduction measures. Supporting information required to develop costs of the various risk-reduction options also is included

Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Durango, Colorado: Attachment 2, Geology report

International Nuclear Information System (INIS)

1991-12-01

Detailed investigations of geologic, geomorphic, and seismic conditions at the Bodo Canyon disposal site were conducted. The purpose of these investigations was basic site characterization and identification of potential geologic hazards that could affect long-term site stability. Subsequent engineering studies, such as analyses of hydrologic and liquefaction hazards, used the data developed in these studies. The geomorphic analysis was employed in the design of effective erosion protection. Studies of the regional and local seismotectonic setting, which included a detailed search for possible capable faults within a 65 kilometer radius of the site, provided the basis for seismic design parameters. The scope of work performed included the following: Compilation and analysis of previous published and unpublished geologic literature and maps; Review of historical and instrumental earthquake data; Review of site-specific subsurface geologic data, including lithologic and geophysical logs of exploratory boreholes advanced in the site area; Photogeologic interpretations of existing conventional aerial photographs; and, Ground reconnaissance and mapping of the site region

An innovative discrete multilevel sampler design

International Nuclear Information System (INIS)

Marvin, B.K.; De Clercq, P.J.; Taylor, B.B.; Mauro, D.M.

1995-01-01

An innovative, small-diameter PVC discrete multilevel sampler (DMLS) was designed for the Electric Power Research Institute (EPRI) to provide low-cost, discrete groundwater samples from shallow aquifers. When combined with appropriately-sized direct push soil sampling technologies, high resolution aquifer characterization can be achieved during initial site assessment or remediation monitoring activities. The sampler is constructed from 1-inch diameter PVC well materials, containing polyethylene tubing threaded through PVC disks. Self-expanding annular and internal bentonite seals were developed which isolate discrete sampling zones. The DMLS design allows customization of sampling and isolation zone lengths to suit site-specific goals. Installation of the DMLS is achieved using a temporary, expendable-tipped casting driven by direct push methods. This technique minimizes mobilization costs, site and soil column disturbances, and allows rapid installation in areas of limited overhead clearance. Successful pilot installations of the DMLS prototype have been made at a former manufactured gas plant (MGP) site and a diesel fuel spill site. Analysis of groundwater samples from these sites, using relative compound distributions and contaminant concentration profiling, confirmed that representative discrete samples were collected. This design provides both economical and versatile groundwater monitoring during all phases of site assessment and remediation

Basic repository environmental assessment design basis, Richton Dome site

International Nuclear Information System (INIS)

1988-01-01

This study examines the engineering factors and costs associated with the construction, operation, and decommissioning of a high-level nuclear waste repository in salt in the Gulf Interior Region at Richton Dome in Perry County, Mississippi. The study assumes a repository capacity of 36,000 metric tons of heavy metal (MTHM) of unreprocessed spent fuel and 36,000 MTHM of commercial high-level reprocessing waste, along with 7,020 canisters of defense high-level reprocessing waste and associated quantities of remote-and contact-handled transuranic waste (TRU). With the exception of TRU, all the waste forms are placed in 300- to 1,000-year-life carbon-steel waste packages in a collocated waste handling and packaging facility (WHPF), which is also described. The construction, operation, and decommissioning of the proposed repository is estimated to cost approximately $4.49 billion. Costs include those for the WHPF, engineering, and contingency, but exclude waste form assembly and shipment to the site and waste package fabrication and shipment to the site. These costs reflect the relative average wage rates of the region and the relatively easy access to the site. Construction would require an estimated 6.25 years. Engineering factors and costs are not strongly influenced by environmental considerations. 52 refs., 24 figs., 20 tabs

Basic repository environmental assessment design basis, Davis Canyon site

International Nuclear Information System (INIS)

1984-01-01

This study examines the engineering factors and costs associated with the construction, operation, and decommissioning of a high-level nuclear waste repository in salt in the Paradox Basin in Davis Canyon, Utah. The study assumes a repository capacity of 36,000 metric tons of heavy metal (MTHM) of unreprocessed spent fuel and 36,000 MTHM of commercial high-level reprocessing waste, along with 7,020 canisters of defense high-level reprocessing waste and associated quantities of remote- and contact-handled transuranic waste (TRU). With the exception of TRU, all the waste forms are placed in 300- to 1,000-year-life carbon-steel waste packages in a collected waste handling and packaging facility (WHPF), which is also described. The construction, operation, and decommissioning of the proposed repository is estimated to cost approximately $5.49 billion. Costs include those for the collocated WHPF, engineering, and contingency, but exclude waste form assembly and shipment to the site and waste package fabrication and shipment to the site. These costs reflect the relative average wage rates of the region and the relatively sound nature of the salt at this site. Construction would require an estimated 7.75 years. Engineering factors and costs are not strongly influenced by environmental considerations. 50 refs., 24 figs., 20 tabs

Basic repository environmental assessment design basis, Lavender Canyon site

International Nuclear Information System (INIS)

1988-01-01

This study examines the engineering factors and costs associated with the construction, operation, and decommissioning of a high-level nuclear waste repository in salt in the Paradox Basin in Lavender Canyon, Utah. The study assumes a repository capacity of 36,000 metric tons of heavy metal (MTHM) of unreprocessed spent fuel and 36,000 MTHM of commercial high-level reprocessing waste, along with 7020 canisters of defense high-level reprocessing waste and associated quantities of remote- and contact-handled transuranic waste (TRU). With the exception of TRU, all the waste forms are placed in 300- to 1000-year-life carbon-steel waste packages in a collocated waste handling and packaging facility (WHPF), which is also described. The construction, operation, and decommissioning of the proposed repository is estimated to cost approximately $5.51 billion. Costs include those for the collocated WHPP, engineering, and contingency, but exclude waste form assembly and shipment to the site and waste package fabrication and shipment to the site. These costs reflect the relative average wage rates of the region and the relatively sound nature of the salt at this site. Construction would require an estimated 7.75 years. Engineering factors and costs are not strongly influenced by environmental considerations. 51 refs., 24 figs., 20 tabs

Reducing Building HVAC Costs with Site-Recovery Energy

Science.gov (United States)

Pargeter, Stephen J.

2012-01-01

Building owners are caught between two powerful forces--the need to lower energy costs and the need to meet or exceed outdoor air ventilation regulations for occupant health and comfort. Large amounts of energy are wasted each day from commercial, institutional, and government building sites as heating, ventilation, and air conditioning (HVAC)…

Transmission line capital costs

International Nuclear Information System (INIS)

Hughes, K.R.; Brown, D.R.

1995-05-01

The displacement or deferral of conventional AC transmission line installation is a key benefit associated with several technologies being developed with the support of the U.S. Department of Energy's Office of Energy Management (OEM). Previous benefits assessments conducted within OEM have been based on significantly different assumptions for the average cost per mile of AC transmission line. In response to this uncertainty, an investigation of transmission line capital cost data was initiated. The objective of this study was to develop a database for preparing preliminary estimates of transmission line costs. An extensive search of potential data sources identified databases maintained by the Bonneville Power Administration (BPA) and the Western Area Power Administration (WAPA) as superior sources of transmission line cost data. The BPA and WAPA data were adjusted to a common basis and combined together. The composite database covers voltage levels from 13.8 to 765 W, with cost estimates for a given voltage level varying depending on conductor size, tower material type, tower frame type, and number of circuits. Reported transmission line costs vary significantly, even for a given voltage level. This can usually be explained by variation in the design factors noted above and variation in environmental and land (right-of-way) costs, which are extremely site-specific. Cost estimates prepared from the composite database were compared to cost data collected by the Federal Energy Regulatory Commission (FERC) for investor-owned utilities from across the United States. The comparison was hampered because the only design specifications included with the FERC data were voltage level and line length. Working within this limitation, the FERC data were not found to differ significantly from the composite database. Therefore, the composite database was judged to be a reasonable proxy for estimating national average costs

Study of site layout in the Rokkasho site

International Nuclear Information System (INIS)

Sato, Kazuyoshi; Tamura, Kousaku; Yagenji, Akira; Sekiya, Shigeki; Takahashi, Hideo; Neyatani, Yuzuru; Uehara, Masaharu; Motohashi, Keiichi; Hashimoto, Masayoshi; Ogino, Shunji; Nagamatsu, Nobuhide

2006-03-01

The Final Design Report (FDR) of the International Thermonuclear Experimental Reactor (ITER) was published on July 2001 as a summary of the Engineering Design Activity (EDA). After the EDA, site dependent design has been investigated for the invitation of ITER toward Rokkasho Site (Iyasakadai area) in Aomori prefecture. This report describes the results of site layout of major buildings and structures of ITER in the Rokkasho-Site. The data of the ground near the site and the results of site dependent design in Japan were applied to this study. Through this study, the most appropriate site layout has been constructed with satisfaction of following conditions. (1) Bedrock level at the tokamak complex building is relatively high and it can be reduced the cost of excavation and foundation work. (2) Total amount of excavation soil for site preparation is minimized and the flexibility of the layout is ensured with flat ground level. (3) Accessibility of human and equipments, reduction of noise and vibration to the environment can be obtained. Total length of ducts and piping between buildings in site is minimized. (author)

Site specific study for possible ongoing salt dome movement

International Nuclear Information System (INIS)

Thoms, R.L.; Manning, T.A.; Paille, L.K.; Gehle, R.M.

1977-01-01

U.S. Gulf Coast salt domes, among other geologic structures, currently are being considered for storage of commercial radioactive wastes. A major concern with dome storage of long lived radioactive wastes lies with the possible tectonic movement of the host dome. Any ongoing movement of a salt dome can be monitored with a site specific complementary system of field instrumentation and finite element modelling. Field instrumentation and accompanying finite element analyses for a study dome in northwest Louisiana are described. Site specific data and early experience associated with tiltmeters over the dome are presented. Also, recommendations are made for modifications and extensions of the field instrumentation and finite element modelling appropriate to the specific site under study

A User-centered Model for Web Site Design

Science.gov (United States)

Kinzie, Mable B.; Cohn, Wendy F.; Julian, Marti F.; Knaus, William A.

2002-01-01

As the Internet continues to grow as a delivery medium for health information, the design of effective Web sites becomes increasingly important. In this paper, the authors provide an overview of one effective model for Web site design, a user-centered process that includes techniques for needs assessment, goal/task analysis, user interface design, and rapid prototyping. They detail how this approach was employed to design a family health history Web site, Health Heritage . This Web site helps patients record and maintain their family health histories in a secure, confidential manner. It also supports primary care physicians through analysis of health histories, identification of potential risks, and provision of health care recommendations. Visual examples of the design process are provided to show how the use of this model resulted in an easy-to-use Web site that is likely to meet user needs. The model is effective across diverse content arenas and is appropriate for applications in varied media. PMID:12087113

Site-specific Probabilistic Analysis of DCGLs Using RESRAD Code

Energy Technology Data Exchange (ETDEWEB)

Kim, Jeongju; Yoon, Suk Bon; Sohn, Wook [KHNP CRI, Daejeon (Korea, Republic of)

2016-10-15

In general, DCGLs can be conservative (screening DCGL) if they do not take into account site specific factors. Use of such conservative DCGLs can lead to additional remediation that would not be required if the effort was made to develop site-specific DCGLs. Therefore, the objective of this work is to provide an example on the use of the RESRAD 6.0 probabilistic (site-specific) dose analysis to compare with the screening DCGL. Site release regulations state that a site will be considered acceptable for unrestricted use if the residual radioactivity that is distinguishable from background radiation results in a Total Effective Dose Equivalent (TEDE) to an average member of the critical group of less than the site release criteria, for example 0.25 mSv per year in U.S. Utilities use computer dose modeling codes to establish an acceptable level of contamination, the derived concentration guideline level (DCGL) that will meet this regulatory limit. Since the DCGL value is the principal measure of residual radioactivity, it is critical to understand the technical basis of these dose modeling codes. The objective this work was to provide example on nuclear power plant decommissioning dose analysis in a probabilistic analysis framework. The focus was on the demonstration of regulatory compliance for surface soil contamination using the RESRAD 6.0 code. Both the screening and site-specific probabilistic dose analysis methodologies were examined. Example analyses performed with the screening probabilistic dose analysis confirmed the conservatism of the NRC screening values and indicated the effectiveness of probabilistic dose analysis in reducing the conservatism in DCGL derivation.

Savannah River Site's Site Specific Plan

Energy Technology Data Exchange (ETDEWEB)

1991-08-01

This Site Specific Plan (SSP) has been prepared by the Savannah River Site (SRS) in order to show the Environmental Restoration and Waste Management activities that were identified during the preparation of the Department of Energy-Headquarters (DOE-HQ) Environmental Restoration and Waste Management Five-Year Plan (FYP) for FY 1992--1996. The SSP has been prepared in accordance with guidance received from DOE-HQ. DOE-SR is accountable to DOE-HQ for the implementation of this plan. The purpose of the SSP is to develop a baseline for policy, budget, and schedules for the DOE Environmental Restoration and Waste Management activities. The plan explains accomplishments since the Fiscal Year (FY) 1990 plan, demonstrates how present and future activities are prioritized, identifies currently funded activities and activities that are planned to be funded in the upcoming fiscal year, and describes future activities that SRS is considering.

76 FR 55370 - Environmental Management Site-Specific Advisory Board, Nevada

Science.gov (United States)

2011-09-07

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY...-Wide Environmental Impact Statement (EIS) Committee of the Environmental Management Site- Specific... the areas of environmental restoration, waste management, and related activities. Purpose of the...

Cost optimization of wind turbines for large-scale offshore wind farms

International Nuclear Information System (INIS)

Fuglsang, P.; Thomsen, K.

1998-02-01

This report contains a preliminary investigation of site specific design of off-shore wind turbines for a large off-shore wind farm project at Roedsand that is currently being proposed by ELKRAFT/SEAS. The results were found using a design tool for wind turbines that involve numerical optimization and aeroelastic calculations of response. The wind climate was modeled in detail and a cost function was used to estimate costs from manufacture and installation. Cost of energy is higher for off-shore installations. A comparison of an off-shore wind farm site with a typical stand alone on-shore site showed an increase of the annual production of 28% due to the difference in wind climate. Extreme loads and blade fatigue loads were nearly identical, however,fatigue loads on other main components increased significantly. Optimizations were carried out to find the optimum overall off-shore wind turbine design. A wind turbine for the off-shore wind farm should be different compared with a stand-alone on-shore wind turbine. The overall design changed were increased swept area and rated power combined with reduced rotor speed and tower height. Cost was reduced by 12% for the final 5D/14D off-shore wind turbine from 0.306 DKr/kWh to 0.270 DKr/kWh. These figures include capital costs from manufacture and installation but not on-going costs from maintenance. These results make off-shore wind farms more competitive and comparable to the reference on-shore stand-alone wind turbine. A corresponding reduction of cost of energy could not be found for the stand alone on-shore wind turbine. Furthermore the fatigue loads on wind turbines in on-shore wind farms will increase and cost of energy will increase in favor of off-shore wind farms. (au) EFP-95; EU-JOULE-3; 21 tabs., 7 ills., 8 refs

76 FR 57981 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2011-09-19

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... environmental restoration, waste management and related activities. Tentative Agenda Call to Order...

77 FR 2283 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2012-01-17

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... environmental restoration, waste management and related activities. Tentative Agenda Call to Order...

76 FR 36100 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2011-06-21

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... environmental restoration, waste management and related activities. Tentative Agenda Call to Order...

77 FR 29997 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2012-05-21

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... environmental restoration, waste management and related activities. Tentative Agenda Call to Order...

77 FR 37390 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2012-06-21

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... environmental restoration, waste management and related activities. Tentative Agenda: Call to Order...

76 FR 78909 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2011-12-20

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... the areas of environmental restoration, waste management, and related activities. Tentative Agenda...

76 FR 50204 - Environmental Management Site-Specific Advisory Board, Nevada

Science.gov (United States)

2011-08-12

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY...-Wide Environmental Impact Statement (EIS) Committee of the Environmental Management Site- Specific... management in the areas of environmental restoration, waste management, and related activities. Purpose of...

77 FR 6790 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2012-02-09

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... environmental restoration, waste management and related activities. Tentative Agenda Call to Order...

75 FR 51026 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2010-08-18

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... the areas of environmental restoration, waste management and related activities. Tentative Agenda...

Specifications in early conceptual design work

DEFF Research Database (Denmark)

Hansen, Claus Thorp; Andreasen, Mogens Myrup

2007-01-01

In early conceptual design the design team is working in an uncertain situation, where the understanding of a need is limited and not much is known about the solution space. In this situation the design team has to both analyse need and explore solution space. Thus, the team has to formulate design...... specifications, which express attractive product goals, and has to synthesise the product idea. The authors of this paper see a challenge to enhance and improve our understanding of the nature of design specifications as a means to support the synthesis of a product idea. In this empirical study we analyse...... the structure and content of design specifications during early ideation activities, where initial design specifications are formulated and a product idea is synthesised. We have analysed specification documents of 19 teams of novice designers. Our analysis indicates that a productive product design...

Basic repository environmental assessment design basis: Deaf Smith County site

International Nuclear Information System (INIS)

1988-03-01

This study examines the engineering factors and costs associated with the construction, operation, and decommissioning of a high-level nuclear waste repository in salt in the Palo Duro Basin in Deaf Smith County, Texas. The study assumes a repository capacity of 36,000 metric tons of heavy metal (MTHM) of unreprocessed spent fuel and 36,000 MTHM of commercial high-level reprocessing waste, along with 7,020 canisters of defense high-level reprocessing waste and associated quantities or remote- and contact-handled transuranic waste (TRU). With the exception of TRU, all the waste forms are placed in 300- to 1000-year-life carbon-steel waste packages in a collocated waste handling and packaging facility (WHPF), which is also described. The construction, operation, and decommissioning of the proposed repository is estimated to cost approximately $4.64 billion. Costs include those for the collocate WHPF, engineering, and contingency, but exclude waste form assembly and shipment to the site and waste package fabrication and shipment to the site. These costs reflect the relative average wage rates of the region, the relatively easy access to the site, and the relatively weak nature of the salt at this site. Construction would require an estimated 7 to 7.5 years. Engineering factors and costs are not strongly influenced by environmental considerations. 62 refs., 24 figs., 20 tabs

75 FR 7577 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2010-02-22

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... areas of environmental restoration, waste management and related activities. Tentative Agenda: Call to...

75 FR 65615 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2010-10-26

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... areas of environmental restoration, waste management and related activities. Tentative Agenda Call to...

76 FR 17118 - Environmental Management Site-Specific Advisory Board Chairs

Science.gov (United States)

2011-03-28

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board Chairs AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB) Chairs. The Federal Advisory Committee Act (Pub... areas of environmental restoration, waste management, and related activities. Tentative Agenda Topics...

76 FR 62054 - Environmental Management Site-Specific Advisory Board Chairs

Science.gov (United States)

2011-10-06

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board Chairs AGENCY... of the Environmental Management Site-Specific Advisory Board (EM SSAB) Chairs. The Federal Advisory... environmental restoration, waste management, and related activities. Tentative Agenda Topics [cir] EM Program...

75 FR 82003 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2010-12-29

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... areas of environmental restoration, waste management and related activities. Tentative Agenda: Call to...

75 FR 19379 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2010-04-14

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... areas of environmental restoration, waste management and related activities. Tentative Agenda Call to...

77 FR 51789 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2012-08-27

... management and related activities. Tentative Agenda Call to Order, Introductions, Review of Agenda... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act...

On-site vs off-site management of environmental restoration waste: A cost effectiveness analysis

International Nuclear Information System (INIS)

Morse, M.A.; Aamodt, P.L.; Cox, W.B.

1996-01-01

The Sandia National Laboratories Environmental Restoration Project is expected to generate relatively large volumes of hazardous waste as a result of cleanup operations. These volumes will exceed the Laboratories existing waste management capacity. This paper presents four options for managing remediation wastes, including three alternatives for on-site waste management utilizing a corrective action management unit (CAMU). Costs are estimated for each of the four options based on current volumetric estimates of hazardous waste. Cost equations are derived for each of the options with the variables being waste volumes, the major unknowns in the analysis. These equations provide a means to update cost estimates as volume estimates change. This approach may be helpful to others facing similar waste management decisions

Prospects for site specific weed management

DEFF Research Database (Denmark)

Christensen, Svend; Rasmussen, Jesper; Pedersen, Søren Marcus

2014-01-01

Research on Site Specific Weed Management (SSWM) started in the late 80's. Since that moment, considerable research has been conducted on different aspects of SSWM, from fundamental studies on the spatial ecology of weeds to the applied development and testing of new technologies for weed detection...

77 FR 2282 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2012-01-17

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... the Environmental Management Site-Specific Advisory Board, Paducah. This notice announces the... Management Officer. [FR Doc. 2012-831 Filed 1-12-12; 4:15 pm] BILLING CODE 6405-01-P ...

Low cost design of microprocessor EDAC circuit

International Nuclear Information System (INIS)

Hao Li; Yu Lixin; Peng Heping; Zhuang Wei

2015-01-01

An optimization method of error detection and correction (EDAC) circuit design is proposed. The method involves selecting or constructing EDAC codes of low cost hardware, associated with operation scheduling implementation based on 2-input XOR gates structure, and two actions for reducing hardware cells, which can reduce the delay penalties and area costs of the EDAC circuit effectively. The 32-bit EDAC circuit hardware implementation is selected to make a prototype, based on the 180 nm process. The delay penalties and area costs of the EDAC circuit are evaluated. Results show that the time penalty and area cost of the EDAC circuitries are affected with different parity-check matrices and different hardware implementation for the EDAC codes with the same capability of correction and detection code. This method can be used as a guide for low-cost radiation-hardened microprocessor EDAC circuit design and for more advanced technologies. (paper)

Basic repository environment assessment design basis, Cypress Creek Dome Site

International Nuclear Information System (INIS)

1988-03-01

This study examines the engineering factors and costs associated with the construction, operation, and decommissioning of a high-level nuclear waste repository in salt in the Gulf Interior Region at Cypress Creek Cone, Mississippi. The study assumes a repository capacity of 36,000 metric tons of heavy metal (MTHM) of unreprocessed spent fuel and 36,000 MTHM of commercial high-level reprocessing waste, along with 7020 canisters of defense high-level reprocessing waste and associated quantities of remote- and contact-handled transuranic waste (TRU). With the exception of TRU, all the waste forms are placed in 300- to 1000-year-life carbon-steel waste packages in a collocated waste handling and packaging facility (WHPF), which is also described. The construction, operation, and decommissioning of the proposed repository is estimated to cost approximately $4.66 billion. Costs include those for the collocated WHPF, engineering, and contingency, but exclude waste from assembly and shipment to the site and waste package fabrication and shipment to the site. These costs reflect the relatively easy access to the site. Construction would require an estimated 7 years. Engineering factors and costs are not strongly influenced by environmental considerations. 53 refs., 24 figs., 10 tabs

SLAC site design aesthetics

International Nuclear Information System (INIS)

Hall, F.F.

1985-10-01

Stanford Linear Accelerator Center (SLAC) is a single mission laboratory dedicated to basic research in high energy particle physics. SLAC site also houses Stanford Synchrotron Radiation Laboratory (SSRL) which is a multi-mission laboratory for research using beams of ultraviolet light and low energy photons as emitted tangentially from SLAC colliding beam facilities. This paper discusses various aspects of SLAC site design aesthetics under the following headings: (1) imposed footprint of SLAC, (2) description of selected site, (3) use of earth cover for radiation and sight screens, (4) use of landscaping for cosmetic purposes, (5) use of exterior paint colors to soften SLAC impact on neighbors, (6) relocation of SLAC main entrance, (7) relocation of SLAC collider arcs and experimental hall, (8) parking lots and storage yards, and (9) land use zoning at SLAC

Reducing Design Cycle Time and Cost Through Process Resequencing

Science.gov (United States)

Rogers, James L.

2004-01-01

In today's competitive environment, companies are under enormous pressure to reduce the time and cost of their design cycle. One method for reducing both time and cost is to develop an understanding of the flow of the design processes and the effects of the iterative subcycles that are found in complex design projects. Once these aspects are understood, the design manager can make decisions that take advantage of decomposition, concurrent engineering, and parallel processing techniques to reduce the total time and the total cost of the design cycle. One software tool that can aid in this decision-making process is the Design Manager's Aid for Intelligent Decomposition (DeMAID). The DeMAID software minimizes the feedback couplings that create iterative subcycles, groups processes into iterative subcycles, and decomposes the subcycles into a hierarchical structure. The real benefits of producing the best design in the least time and at a minimum cost are obtained from sequencing the processes in the subcycles.

WSDM : A user-centred design method for web sites

NARCIS (Netherlands)

de Troyer, O.M.F.; Leune, C.J.

1998-01-01

WSDM is a user-centered method for the design of kiosk Web Sites. By explicitly starting from the requirements of the users or visitors, WSDM solves Web site problems that are primarily caused by that fact that a site has no underlying design at all, or that the design is mostly data-driven.

Design and component specifications for high average power laser optical systems

Energy Technology Data Exchange (ETDEWEB)

O' Neil, R.W.; Sawicki, R.H.; Johnson, S.A.; Sweatt, W.C.

1987-01-01

Laser imaging and transport systems are considered in the regime where laser-induced damage and/or thermal distortion have significant design implications. System design and component specifications are discussed and quantified in terms of the net system transport efficiency and phase budget. Optical substrate materials, figure, surface roughness, coatings, and sizing are considered in the context of visible and near-ir optical systems that have been developed at Lawrence Livermore National Laboratory for laser isotope separation applications. In specific examples of general applicability, details of the bulk and/or surface absorption, peak and/or average power damage threshold, coating characteristics and function, substrate properties, or environmental factors will be shown to drive the component size, placement, and shape in high-power systems. To avoid overstressing commercial fabrication capabilities or component design specifications, procedures will be discussed for compensating for aberration buildup, using a few carefully placed adjustable mirrors. By coupling an aggressive measurements program on substrates and coatings to the design effort, an effective technique has been established to project high-power system performance realistically and, in the process, drive technology developments to improve performance or lower cost in large-scale laser optical systems. 13 refs.

Design and component specifications for high average power laser optical systems

International Nuclear Information System (INIS)

O'Neil, R.W.; Sawicki, R.H.; Johnson, S.A.; Sweatt, W.C.

1987-01-01

Laser imaging and transport systems are considered in the regime where laser-induced damage and/or thermal distortion have significant design implications. System design and component specifications are discussed and quantified in terms of the net system transport efficiency and phase budget. Optical substrate materials, figure, surface roughness, coatings, and sizing are considered in the context of visible and near-ir optical systems that have been developed at Lawrence Livermore National Laboratory for laser isotope separation applications. In specific examples of general applicability, details of the bulk and/or surface absorption, peak and/or average power damage threshold, coating characteristics and function, substrate properties, or environmental factors will be shown to drive the component size, placement, and shape in high-power systems. To avoid overstressing commercial fabrication capabilities or component design specifications, procedures will be discussed for compensating for aberration buildup, using a few carefully placed adjustable mirrors. By coupling an aggressive measurements program on substrates and coatings to the design effort, an effective technique has been established to project high-power system performance realistically and, in the process, drive technology developments to improve performance or lower cost in large-scale laser optical systems. 13 refs

AFB/open cycle gas turbine conceptual design study

Science.gov (United States)

Dickinson, T. W.; Tashjian, R.

1983-09-01

Applications of coal fired atmospheric fluidized bed gas turbine systems in industrial cogeneration are identified. Based on site-specific conceptual designs, the potential benefits of the AFB/gas turbine system were compared with an atmospheric fluidized design steam boiler/steam turbine system. The application of these cogeneration systems at four industrial plant sites is reviewed. A performance and benefit analysis was made along with a study of the representativeness of the sites both in regard to their own industry and compared to industry as a whole. A site was selected for the conceptual design, which included detailed site definition, AFB/gas turbine and AFB/steam turbine cogeneration system designs, detailed cost estimates, and comparative performance and benefit analysis. Market and benefit analyses identified the potential market penetration for the cogeneration technologies and quantified the potential benefits.

Private-Sector Cleanup Expenditures and Transaction Costs at 18 Superfund Sites (1993)

Science.gov (United States)

Superfund allows the government either to clean up a site and recover its cost from the potentially responsible parties (PRPs) or to require the PRPs to undertake the cleanup themselves. This study examines private-sector expenditures and transaction-costs

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay.

Science.gov (United States)

Cui, Heying; Loftus, Kyle M; Noell, Crystal R; Solmaz, Sozanne R

2018-05-03

Cyclin-dependent kinase 1 (Cdk1) is a master controller for the cell cycle in all eukaryotes and phosphorylates an estimated 8 - 13% of the proteome; however, the number of identified targets for Cdk1, particularly in human cells is still low. The identification of Cdk1-specific phosphorylation sites is important, as they provide mechanistic insights into how Cdk1 controls the cell cycle. Cell cycle regulation is critical for faithful chromosome segregation, and defects in this complicated process lead to chromosomal aberrations and cancer. Here, we describe an in vitro kinase assay that is used to identify Cdk1-specific phosphorylation sites. In this assay, a purified protein is phosphorylated in vitro by commercially available human Cdk1/cyclin B. Successful phosphorylation is confirmed by SDS-PAGE, and phosphorylation sites are subsequently identified by mass spectrometry. We also describe purification protocols that yield highly pure and homogeneous protein preparations suitable for the kinase assay, and a binding assay for the functional verification of the identified phosphorylation sites, which probes the interaction between a classical nuclear localization signal (cNLS) and its nuclear transport receptor karyopherin α. To aid with experimental design, we review approaches for the prediction of Cdk1-specific phosphorylation sites from protein sequences. Together these protocols present a very powerful approach that yields Cdk1-specific phosphorylation sites and enables mechanistic studies into how Cdk1 controls the cell cycle. Since this method relies on purified proteins, it can be applied to any model organism and yields reliable results, especially when combined with cell functional studies.

National Ignition Facility subsystem design requirements NIF site improvements SSDR 1.2.1

International Nuclear Information System (INIS)

Kempel, P.; Hands, J.

1996-01-01

This Subsystem Design Requirements (SSDR) document establishes the performance, design, and verification requirements associated with the NIF Project Site at Lawrence Livermore National Laboratory (LLNL) at Livermore, California. It identifies generic design conditions for all NIF Project facilities, including siting requirements associated with natural phenomena, and contains specific requirements for furnishing site-related infrastructure utilities and services to the NIF Project conventional facilities and experimental hardware systems. Three candidate sites were identified as potential locations for the NIF Project. However, LLNL has been identified by DOE as the preferred site because of closely related laser experimentation underway at LLNL, the ability to use existing interrelated infrastructure, and other reasons. Selection of a site other than LLNL will entail the acquisition of site improvements and infrastructure additional to those described in this document. This SSDR addresses only the improvements associated with the NIF Project site located at LLNL, including new work and relocation or demolition of existing facilities that interfere with the construction of new facilities. If the Record of Decision for the PEIS on Stockpile Stewardship and Management were to select another site, this SSDR would be revised to reflect the characteristics of the selected site. Other facilities and infrastructure needed to support operation of the NIF, such as those listed below, are existing and available at the LLNL site, and are not included in this SSDR. Office Building. Target Receiving and Inspection. General Assembly Building. Electro- Mechanical Shop. Warehousing and General Storage. Shipping and Receiving. General Stores. Medical Facilities. Cafeteria services. Service Station and Garage. Fire Station. Security and Badging Services

Design windows and cost analysis on helical reactors

International Nuclear Information System (INIS)

Kozaki, Y.; Imagawa, S.; Sagara, A.

2007-01-01

The LHD type helical reactors are characterized by a large major radius but slender helical coil, which give us different approaches for power plants from tokamak reactors. For searching design windows of helical reactors and discussing their potential as power plants, we have developed a mass-cost estimating model linked with system design code (HeliCos), thorough studying the relationships between major plasma parameters and reactor parameters, and weight of major components. In regard to cost data we have much experience through preparing ITER construction. To compare the weight and cost of magnet systems between tokamak and helical reactors, we broke down magnet systems and cost factors, such as weights of super conducting strands, conduits, support structures, and winding unit costs, through estimating ITER cost data basis. Based on FFHR2m1 deign we considered a typical 3 GWth helical plant (LHD type) with the same magnet size, coil major radius Rc 14 m, magnetic energy 120 GJ, but increasing plasma densities. We evaluated the weight and cost of magnet systems of 3 GWth helical plant, the total magnet weights of 16,000ton and costs of 210 BYen, which are similar values of tokamak reactors (10,200 ton, 110 BYen in ITER 2002 report, and 21,900 ton, 275 BYen in ITER FDR1999). The costs of strands and winding occupy 70% of total magnet costs, and influence entire power plants economics. The design windows analysis and comparative economics studies to optimize the main reactor parameters have been carried out. Economics studies show that it is misunderstanding to consider helical coils are too large and too expensive to achieve power plants. But we should notice that the helical reactor design windows and economics are very sensitive to allowable blanket space (depend on ergodic layer conditions) and diverter configuration for decreasing heat loads. (orig.)

76 FR 20651 - Environmental Management Site-Specific Advisory Board Chairs

Science.gov (United States)

2011-04-13

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board Chairs AGENCY... a meeting on April 13-14, 2011 of the Environmental Management Site-Specific Advisory Board Chairs... R. Butler, Acting Deputy Committee Management Officer. [FR Doc. 2011-8970 Filed 4-8-11; 4:15 pm...

FLP recombinase-mediated site-specific recombination in silkworm, Bombyx mori

Science.gov (United States)

A comprehensive understanding of gene function and the production of site-specific genetically modified mutants are two major goals of genetic engineering in the post-genomic era. Although site-specific recombination systems have been powerful tools for genome manipulation of many organisms, they h...

Remediation of polluted sites. The risks, liabilities and costs; Rehabilitation de sites pollues. Quels risques? Quelles responsabilites? Quels couts?

Energy Technology Data Exchange (ETDEWEB)

Paquot, A. [Ministere de l' Ecologie et du Developpement Durable 75 - Paris (France); Darmendrail, D. [BRGM, 75 - Paris (France); Mensah, J. [Etablissement public foncier Nord Pas de Calais, 59 - Lille (France); Costil, J. [BURGEAP, 69 - Lyon (France); Carbon, S. [Gaz de France (GDF), 75 - Paris (France); Gervaise, Y. [SGS Multilab, 51 - Rouen (France); Bonin, H. [GRS Valtech, 69 - Rilleux-la-Pape (France); Delfaud, L. [Projenor, 59 - Lille (France); Croze, V. [ICF Environnement, 92 - Gennevilliers (France); Ricour, J. [ANTEA, des solutions globales, durables et rentables, 45 - Orleans (France); Langlois, P.

2003-10-01

This conference deals with the following topics: the mastery of the economic, regulation, juridical and contractual framework; liabilities and financing distribution between the intervenors; the diagnostic cost; the financial security in the sites acquisition and social right transfer; the efficient technologies of sites remediation; the communication near the site in remediation. (A.L.B.)

Precision agriculture - from mapping to site-specific application

DEFF Research Database (Denmark)

Pedersen, Søren Marcus; Lind, Kim Martin Hjorth

2017-01-01

of each chapter in the book. Each chapter address a different topic starting with an overview of technologies that are currently available, followed by specific Variable-Rate Technologies such as VRT fertilizer application, VRT pesticide application, site-specific irrigation management, Auto...

Design issues and cost implications of RTO/RC-ITER divertor

International Nuclear Information System (INIS)

Ibbott, C.; Antipenkov, A.; Chiocchio, S.; Federici, G.; Heidl, H.; Janeschitz, G.; Martin, E.; Tivey, R.

2000-01-01

This paper reports on the conceptual divertor design developed for the reduced technical objectives/reduced cost-international thermonuclear experimental reactor (RTO/RC-ITER). The cost drivers are discussed and a number of cost-reducing measures identified. Scaled costs, based on industrial estimates of the 1998 ITER design (Technical Basis for the ITER Final Design Report, Cost Review and Safety Analysis (FDR). ITER EDA Documentation Series No. 16. IAEA, Vienna, 1998), give for the RTO/RC-ITER ∼60% of the FDR costs. Plasma facing components (PFCs) account for 75% of the total divertor costs. Hence, PFC design simplifications are outlined in the paper showing the possibility of achieving a cost reduction of 50%. The design proposals, outlined in the paper, focus on minimising the number of sub-components and simplifying the manufacturing cycle. These changes contribute to improved reliability based on a more robust coolant design layout. The reduced space allocated to the divertor (G. Janeschitz, A. Antipenkov, V. Barabash, S. Chiocchio, G. Federici, C. Ibbott, E. Martin, R. Tivey, Overview of the Divertor Design and its Integration into RTO/RC-ITER, this conference) requires changes to the design that minimise the cassette body thickness, relocate the cassette attachments and revise the remote handling philosophy. Results of supporting electro-magnetic, neutron shielding, thermo-hydraulic and pumping conductance analyses are reported, qualifying the cassette design. A reduction in the coolant inlet temperature to 100-120 deg. C is discussed in terms of thermal-hydraulic performance and fatigue life of the heat sink. Finally, an R and D plan sets out the work needed: (1) to develop the cost saving measures of the new design; and (2) to demonstrate the reliability of the chosen technologies

Integrated cost estimation methodology to support high-performance building design

Energy Technology Data Exchange (ETDEWEB)

Vaidya, Prasad; Greden, Lara; Eijadi, David; McDougall, Tom [The Weidt Group, Minnetonka (United States); Cole, Ray [Axiom Engineers, Monterey (United States)

2007-07-01

Design teams evaluating the performance of energy conservation measures (ECMs) calculate energy savings rigorously with established modelling protocols, accounting for the interaction between various measures. However, incremental cost calculations do not have a similar rigor. Often there is no recognition of cost reductions with integrated design, nor is there assessment of cost interactions amongst measures. This lack of rigor feeds the notion that high-performance buildings cost more, creating a barrier for design teams pursuing aggressive high-performance outcomes. This study proposes an alternative integrated methodology to arrive at a lower perceived incremental cost for improved energy performance. The methodology is based on the use of energy simulations as means towards integrated design and cost estimation. Various points along the spectrum of integration are identified and characterized by the amount of design effort invested, the scheduling of effort, and relative energy performance of the resultant design. It includes a study of the interactions between building system parameters as they relate to capital costs. Several cost interactions amongst energy measures are found to be significant.The value of this approach is demonstrated with alternatives in a case study that shows the differences between perceived costs for energy measures along various points on the integration spectrum. These alternatives show design tradeoffs and identify how decisions would have been different with a standard costing approach. Areas of further research to make the methodology more robust are identified. Policy measures to encourage the integrated approach and reduce the barriers towards improved energy performance are discussed.

Innovative grinding wheel design for cost-effective machining of advanced ceramics

Energy Technology Data Exchange (ETDEWEB)

Licht, R.H.; Kuo, P.; Liu, S.; Murphy, D.; Picone, J.W.; Ramanath, S.

2000-05-01

This Final Report covers the Phase II Innovative Grinding Wheel (IGW) program in which Norton Company successfully developed a novel grinding wheel for cost-effective cylindrical grinding of advanced ceramics. In 1995, Norton Company successfully completed the 16-month Phase I technical effort to define requirements, design, develop, and evaluate a next-generation grinding wheel for cost-effective cylindrical grinding of advanced ceramics using small prototype wheels. The Phase II program was initiated to scale-up the new superabrasive wheel specification to larger diameters, 305-mm to 406-mm, required for most production grinding of cylindrical ceramic parts, and to perform in-house and independent validation grinding tests.

Econometric estimation of country-specific hospital costs

Directory of Open Access Journals (Sweden)

Murray Christopher JL

2003-02-01

Full Text Available Abstract Information on the unit cost of inpatient and outpatient care is an essential element for costing, budgeting and economic-evaluation exercises. Many countries lack reliable estimates, however. WHO has recently undertaken an extensive effort to collect and collate data on the unit cost of hospitals and health centres from as many countries as possible; so far, data have been assembled from 49 countries, for various years during the period 1973–2000. The database covers a total of 2173 country-years of observations. Large gaps remain, however, particularly for developing countries. Although the long-term solution is that all countries perform their own costing studies, the question arises whether it is possible to predict unit costs for different countries in a standardized way for short-term use. The purpose of the work described in this paper, a modelling exercise, was to use the data collected across countries to predict unit costs in countries for which data are not yet available, with the appropriate uncertainty intervals. The model presented here forms part of a series of models used to estimate unit costs for the WHO-CHOICE project. The methods and the results of the model, however, may be used to predict a number of different types of country-specific unit costs, depending on the purpose of the exercise. They may be used, for instance, to estimate the costs per bed-day at different capacity levels; the "hotel" component of cost per bed-day; or unit costs net of particular components such as drugs. In addition to reporting estimates for selected countries, the paper shows that unit costs of hospitals vary within countries, sometimes by an order of magnitude. Basing cost-effectiveness studies or budgeting exercises on the results of a study of a single facility, or even a small group of facilities, is likely to be misleading.

Beyond Trust: Web Site Design Preferences Across Cultures

OpenAIRE

Dianne Cyr; Carole Bonanni; John Bowes; Joe Ilsever

2005-01-01

The growth of Internet shopping motivates a better understanding of how e-loyalty is built online between businesses and consumers. In this study, Web site design and culture are advanced as important to Web site trust, Web site satisfaction, and e-loyalty in online business relationships. Based on data collected in Canada, the U.S., Germany, and Japan, the research considers (1) examining within culture preferences for design elements of a local vs. a foreign Web site and subsequent particip...

Site-specific assessments of the abundance of three inshore dolphin species to inform conservation and management

Directory of Open Access Journals (Sweden)

Alexander Mark Brown

2016-02-01

Full Text Available Assessing the abundance of wildlife populations is essential to their effective conservation and management. Concerns have been raised over the vulnerability of tropical inshore dolphins in waters off northern Australia to anthropogenic impacts on local populations, yet a lack of abundance data precludes assessment of their conservation status and the management of threats. Using small vessels as cost-effective research platforms, photo-identification surveys and capture-recapture models were applied to provide the first quantitative abundance data for Australian snubfin (Orcaella heinsohni, Australian humpback (Sousa sahulensis, and Indo-Pacific bottlenose dolphins (Tursiops aduncus at five sites in the Kimberley region of north-western Australia. The abundance of each species was highly variable between different sites, likely reflecting species-specific habitat preferences. Within the c. 130 km2 study sites, the estimated abundance of most species was ≤ 60 individuals (excluding calves, and fewer than 20 humpback dolphins were identified at each site in any one 3-5 week sampling period. However, larger estimates of c. 130 snubfin and c. 160 bottlenose dolphins were obtained at two different sites. Several local populations showed evidence of site fidelity, particularly snubfin dolphins. By implementing a standardized, multi-site approach, data on local populations were provided within a broader, regional context, and indicated that each species is patchily distributed in the region. This highlights the need for site-specific baseline data collection using appropriate survey techniques to quantitatively assess the potential impacts of threatening activities to local populations. These findings further illustrate the need to gain a greater understanding of known and potential threats to inshore dolphin populations, their relative impacts, and to mitigate where necessary. In particular, the level of interactions with inshore gillnet fisheries

Designation of facility usage categories for Hanford Site facilities

International Nuclear Information System (INIS)

Wodrich, D.; Ellingson, D.; Scott, M.; Schade, A.

1991-01-01

This report summarizes the Hanford Site methodology used to ensure facility compliance with the natural phenomena design criteria set forth in the US Department of Energy orders and guidance. In particular, the Hanford Site approach to designating a suitable facility open-quotes Usage Category,close quotes is presented. The current Hanford Site methodology for Usage Category designation is based on an engineered feature's safety function and on the feature's assigned Safety Class. At the Hanford Site, Safety Class assignments are deterministic in nature and are based on the consequences of failure, without regard to the likelihood of occurrence. The report also proposes a risk-based approach to Usage Category designation, which is being considered for future application at the Hanford Site. To establish a proper Usage Category designation, the safety analysis and engineering design processes must be coupled. This union produces a common understanding of the safety function(s) to be accomplished by the design feature(s) and a sound basis for the assignment of Usage Categories to the appropriate systems, structures, and components

Exploratory shaft conceptual design report: Permian Basin

International Nuclear Information System (INIS)

1983-07-01

This conceptual design report summarizes the conceptualized design for an exploratory shaft facility at a representative site in the Permian Basin locatd in the western part of Texas. Conceptualized designs for other possible locations (Paradox Basin in Utah and Gulf Interior Region salt domes in Louisiana and Mississippi) are summarized in separate reports. The purpose of the exploratory shaft facility is to provide access to the reference repository horizon to permit in situ testing of the salt. The in situ testing is necessary to verify repository salt design parameters, evaluate isotropy and homogeneity of the salt, and provide a demonstration of the constructability and confirmation of the design to gain access to the repository. The fundamental purpose of this conceptual design report is to assure the feasibility of the exploratory shaft project and to develop a reliable cost estimate and realistic schedule. Because a site has not been selected and site-specific subsurface data are not available, it has been necessary to make certain assumptions in order to develop a conceptual design for an exploratory shaft facility in salt. As more definitive information becomes available to support the design process, adjustments in the projected schedule and estimated costs will be required

Exploratory shaft conceptual design report: Paradox Basin

International Nuclear Information System (INIS)

1983-07-01

This conceptual design report summarizes the conceptualized design for an exploratory shaft facility at a representative site in the Paradox Basin located in the southeastern part of Utah. Conceptualized designs for other possible locations (Permian Basin in Texas and Gulf Interior Region salt domes in Louisiana and Mississippi) are summarized in separate reports. The purpose of the exploratory shaft facility is to provide access to the reference repository horizon to permit in situ testing of the salt. The in-situ testing is necessary to verify repository salt design parameters, evaluate isotropy and homogeneity of the salt, and provide a demonstration of the constructability and confirmation of the design to gain access to the repository. The fundamental purpose of this conceptual design report is to assure the feasibility of the exploratory shaft project and to develop a reliable cost estimate and realistic schedule. Because a site has not been selected and site-specific subsurface data are not available, it has been necessary to make certain assumptions in order to develop a conceptual design for an exploratory shaft facility in salt. As more definitive information becomes available to support the design process, adjustments in the projected schedule and estimated costs will be required

Cost-Based Design and Selection of Point Absorber Devices for the Mediterranean Sea

Directory of Open Access Journals (Sweden)

Vincenzo Piscopo

2018-04-01

Full Text Available Sea wave energy is one of the most promising renewable sources, even if relevant technology is not mature enough for the global energy market and is not yet competitive if compared with solar, wind and tidal current devices. Particularly, among the variety of wave energy converters developed in the last decade, heaving point absorbers represent one of the most feasible and studied technologies, as shown by the small-scale testing and full-scale prototypes, deployed in the last years throughout the world. Nevertheless, the need for further reduction of the energy production costs requires a specialized design of wave energy converters, accounting for the restraints provided by the power take-off unit and the device operational profile. Hence, actual analysis focuses on a new cost-based design procedure for heaving point absorbers. The device is equipped with a floating buoy with an optional fully submerged mass connected, by means of a tensioned line, to the power take-off unit. It consists of a permanent magnet linear generator, lying on the seabed and equipped with a gravity-based foundation. The proposed procedure is applied to several candidate deployment sites located in the Mediterranean Sea; the incidence of the power take-off restraint and the converter operational profile is fully investigated and some recommendations for preliminary design of wave energy converter devices are provided. Current results show that there is wide scope to make the wave energy sector more competitive on the international market, by properly selecting the main design parameters of point absorbers, on the basis of met-ocean conditions at the deployment site.

Rational Catalyst Design of Titanium-Silica Materials Aided by Site-Specific Titration Tools

Science.gov (United States)

Eaton, Todd Robert

between particle and crystal size, as obtained from XRD. In the course of establishing these relationships we've gained the knowledge of how to control TiO x structure, which enables the design of new and better catalysts. Understanding the synthesis-structure-function relationships allow for the design of a tandem photo/thermocatalytic reaction system for producing and consuming H2O2. By partially overcoating a TiO 2 photocatalyst with a ˜2 nm silica layer we observe a 56-fold rate improvement compared to bare-TiO2 for H2O2 synthesis from the proton-assisted reduction of O2. Addition of metal-SiO2 thermocatalysts (metal=Ti, Nb, or Ta) with sites needed for H2O2 activation creates a tandem system wherein the H2O2 produced in situ is utilized for alkene epoxidation. Compared to a thermocatalytic-only system, the tandem system accelerates epoxidation for cis-cyclooctene(11x faster), styrene(20x) and 1-octene(30x). This approach demonstrates a means for epoxidation with O2 that avoids H2O2 purification and transport, simplifies the total process, provides new opportunities for control by independent H2O2 production and consumption in the same reactor, and enhances rates relative to thermocatalytic-only epoxidation by intimately coupling H2O2 generation and consumption. Critically, establishment of titanium-silica synthesis-structure-function relationships enables the design of new catalysts and systems that are less energy- and material-intensive, leading towards more sustainable chemistry.

Design Of A Low Cost Anthropomorphic Robot Hand For Industrial Applications

Science.gov (United States)

Allen, P.; Raleigh, B.

2009-11-01

Autonomous grasping systems using anthropomorphic robotic end effectors have many applications, and the potential of such devices has inspired researchers to develop many types of grasping systems over the past 30 years. Their research has yielded significant advances in end effector dexterity and functionality. However, due to the cost and complexity associated with such devices, their role has been largely confined to that of being research tools in laboratories. Industry, by contrast, has largely opted for simple, single task, devices. This paper presents a novel low cost anthropomorphic robotic end effector, and in particular the design characteristics that make it more applicable to industrial application. The design brief was (i) to be broadly similar to the human hand in terms of size and performance (ii) be low cost (less than €5000 for the system) and (iii) to provide sufficient performance to allow use in industrial applications. Consisting of three fingers and an opposing thumb, the robotic hand developed has a total of 12 automated degrees of freedom. Another 4 degrees of freedom can be set manually. The specific design of the fingers and thumb, together with the drive arrangement utilizing synchronous belts, yields a simplified kinematics solution for the control of movement. The modular nature of the design is extended also to the palm, which can be easily modified to produce different overall work envelopes for the hand. The drive system and grasping strategies are also detailed.

Geology, Bedrock, Tabular data involving the location of design specifics for wells related to the Low-level Radioactive Waste (LLRW) Site Characterization., Published in 1998, North Carolina Department of Environment and Natural Resources (DENR).

Data.gov (United States)

NSGIC State | GIS Inventory — Geology, Bedrock dataset current as of 1998. Tabular data involving the location of design specifics for wells related to the Low-level Radioactive Waste (LLRW) Site...

GPS 2.1: enhanced prediction of kinase-specific phosphorylation sites with an algorithm of motif length selection.

Science.gov (United States)

Xue, Yu; Liu, Zexian; Cao, Jun; Ma, Qian; Gao, Xinjiao; Wang, Qingqi; Jin, Changjiang; Zhou, Yanhong; Wen, Longping; Ren, Jian

2011-03-01

As the most important post-translational modification of proteins, phosphorylation plays essential roles in all aspects of biological processes. Besides experimental approaches, computational prediction of phosphorylated proteins with their kinase-specific phosphorylation sites has also emerged as a popular strategy, for its low-cost, fast-speed and convenience. In this work, we developed a kinase-specific phosphorylation sites predictor of GPS 2.1 (Group-based Prediction System), with a novel but simple approach of motif length selection (MLS). By this approach, the robustness of the prediction system was greatly improved. All algorithms in GPS old versions were also reserved and integrated in GPS 2.1. The online service and local packages of GPS 2.1 were implemented in JAVA 1.5 (J2SE 5.0) and freely available for academic researches at: http://gps.biocuckoo.org.

A neural network based methodology to predict site-specific spectral acceleration values

Science.gov (United States)

Kamatchi, P.; Rajasankar, J.; Ramana, G. V.; Nagpal, A. K.

2010-12-01

A general neural network based methodology that has the potential to replace the computationally-intensive site-specific seismic analysis of structures is proposed in this paper. The basic framework of the methodology consists of a feed forward back propagation neural network algorithm with one hidden layer to represent the seismic potential of a region and soil amplification effects. The methodology is implemented and verified with parameters corresponding to Delhi city in India. For this purpose, strong ground motions are generated at bedrock level for a chosen site in Delhi due to earthquakes considered to originate from the central seismic gap of the Himalayan belt using necessary geological as well as geotechnical data. Surface level ground motions and corresponding site-specific response spectra are obtained by using a one-dimensional equivalent linear wave propagation model. Spectral acceleration values are considered as a target parameter to verify the performance of the methodology. Numerical studies carried out to validate the proposed methodology show that the errors in predicted spectral acceleration values are within acceptable limits for design purposes. The methodology is general in the sense that it can be applied to other seismically vulnerable regions and also can be updated by including more parameters depending on the state-of-the-art in the subject.

Equipment Specific Optimum Blast-Design Using Genetic Algorithm

Directory of Open Access Journals (Sweden)

Rahul Upadhyay

2015-08-01

Full Text Available Design of blasting parameters plays an important role in the optimization of mining cost as well as cost of subsequent processing of ore. Drilling and handling costs are the major mining cost. This work presents an indirect optimization model for mining cost through optimization of blasting parameters for a particular set of drilling and loading equipment.

LMFBR safety criteria: cost-benefit considerations under the constraint of an a priori risk criterion

International Nuclear Information System (INIS)

Hartung, J.

1979-01-01

The role of cost-benefit considerations and a priori risk criteria as determinants of Core Disruptive Accident (CDA)-related safety criteria for large LMFBR's is explored with the aid of quantitative risk and probabilistic analysis methods. A methodology is described which allows a large number of design and siting alternatives to be traded off against each other with the goal of minimizing energy generation costs subject to the constraint of both an a priori risk criterion and a cost-benefit criterion. Application of this methodology to a specific LMFBR design project is described and the results are discussed. 5 refs

Deconstructing thermodynamic parameters of a coupled system from site-specific observables.

Science.gov (United States)

Chowdhury, Sandipan; Chanda, Baron

2010-11-02

Cooperative interactions mediate information transfer between structural domains of a protein molecule and are major determinants of protein function and modulation. The prevalent theories to understand the thermodynamic origins of cooperativity have been developed to reproduce the complex behavior of a global thermodynamic observable such as ligand binding or enzyme activity. However, in most cases the measurement of a single global observable cannot uniquely define all the terms that fully describe the energetics of the system. Here we establish a theoretical groundwork for analyzing protein thermodynamics using site-specific information. Our treatment involves extracting a site-specific parameter (defined as χ value) associated with a structural unit. We demonstrate that, under limiting conditions, the χ value is related to the direct interaction terms associated with the structural unit under observation and its intrinsic activation energy. We also introduce a site-specific interaction energy term (χ(diff)) that is a function of the direct interaction energy of that site with every other site in the system. When combined with site-directed mutagenesis and other molecular level perturbations, analyses of χ values of site-specific observables may provide valuable insights into protein thermodynamics and structure.

Interim Design Report

CERN Document Server

Choubey, S.; Goswami, S.; Berg, J.S.; Fernow, R.; Gallardo, J.C.; Gupta, R.; Kirk, H.; Simos, N.; Souchlas, N.; Ellis, M.; Kyberd, P.; Benedetto, E.; Fernandez-Martinez, E.; Efthymiopoulos, I.; Garoby, R.; Gilardoni, S.; Martini, M.; Prior, G.; Ballett, P.; Pascoli, S.; Bross, A.; Geer, S.; Johnstone, C.; Kopp, J.; Mokhov, N.; Morfin, J.; Neuffer, D.; Parke, S.; Popovic, M.; Strait, J.; Striganov, S.; Blondel, A.; Dufour, F.; Laing, A.; Soler, F.J.P; Lindner, M.; Schwetz, T.; Alekou, A.; Apollonio, M.; Aslaninejad, M.; Bontoiu, C.; Dornan, P.; Eccleston, R.; Kurup, A.; Long, K.; Pasternak, J.; Pozimski, J.; Bogacz, A.; Morozov, V.; Roblin, Y.; Bhattacharya, S.; Majumdar, D.; Mori, Y.; Planche, T.; Zisman, M.; Cline, D.; Stratakis, D.; Ding, X.; Coloma, P.; Donini, A.; Gavela, B.; Lopez Pavon, J.; Maltoni, M.; Bromberg, C.; Bonesini, M.; Hart, T.; Kudenko, Y.; Mondal, N.; Antusch, S.; Blennow, M.; Ota, T.; Abrams, R.J.; Ankenbrandt, C.M.; Beard, K.B.; Cummings, M.A.C.; Flanagan, G.; Johnson, R.P.; Roberts, T.J.; Yoshikawa, C.Y.; Migliozzi, P.; Palladino, V.; de Gouvea, A.; Graves, V.B.; Kuno, Y.; Peltoniemi, J.; Blackmore, V.; Cobb, J.; Witte, H.; Mezzetto, M.; Rigolin, S.; McDonald, K.T.; Coney, L.; Hanson, G.; Snopok, P.; Tortora, L.; Andreopoulos, C.; Bennett, J.R.J.; Brooks, S.; Caretta, O.; Davenne, T.; Densham, C.; Edgecock, R.; Kelliher, D.; Loveridge, P.; McFarland, A.; Machida, S.; Prior, C.; Rees, G.; Rogers, C.; Thomason, J.W.G.; Booth, C.; Skoro, G.; Karadzhov, Y.; Matev, R.; Tsenov, R.; Samulyak, R.; Mishra, S.R.; Petti, R.; Dracos, M.; Yasuda, O.; Agarwalla, S.K.; Cervera-Villanueva, A.; Gomez-Cadenas, J.J.; Hernandez, P.; Li, T.; Martin-Albo, J.; Huber, P.; Back, J.; Barker, G.; Harrison, P.; Meloni, D.; Tang, J.; Winter, W.

2011-01-01

The International Design Study for the Neutrino Factory (the IDS-NF) was established by the community at the ninth "International Workshop on Neutrino Factories, super-beams, and beta- beams" which was held in Okayama in August 2007. The IDS-NF mandate is to deliver the Reference Design Report (RDR) for the facility on the timescale of 2012/13. In addition, the mandate for the study [3] requires an Interim Design Report to be delivered midway through the project as a step on the way to the RDR. This document, the IDR, has two functions: it marks the point in the IDS-NF at which the emphasis turns to the engineering studies required to deliver the RDR and it documents baseline concepts for the accelerator complex, the neutrino detectors, and the instrumentation systems. The IDS-NF is, in essence, a site-independent study. Example sites, CERN, FNAL, and RAL, have been identified to allow site-specific issues to be addressed in the cost analysis that will be presented in the RDR. The choice of example sites shou...

Site-Specific Analyses for Demonstrating Compliance with 10 CFR 61 Performance Objectives - 12179

Energy Technology Data Exchange (ETDEWEB)

Grossman, C.J.; Esh, D.W.; Yadav, P.; Carrera, A.G. [U.S. Nuclear Regulatory Commission, 11545 Rockville Pike, Rockville, MD 20852 (United States)

2012-07-01

performance assessment to demonstrate protection of the general population from releases of radioactivity, an assessment to demonstrate protection of a potential inadvertent intruder, and a long-term analysis to assess how the design of the facility considers the potential radiological impacts associated with disposal of long-lived waste streams. Concurrently, the NRC staff intends to propose associated guidance to facilitate the implementation of the requirements to conduct site-specific analyses. In proposing these amendments to the regulation and associated guidance, the NRC staff has conducted extensive public outreach since 2009 including three public meetings and four briefings of the NRC's Advisory Committee on Reactor Safeguards. The NRC staff plans to submit the proposed amendments to the regulations to the Commission in early 2012. Subsequently, the proposed amendments and associated guidance would be published in the Federal Register for public comment pending approval of the proposed amendments to the regulations by the Commission. Following the public comment period, NRC staff plans to address public comments and revise, as necessary, the regulations and associated guidance before publishing a final rule, which is anticipated in 2013. (authors)

Plastic freezer bags: a cost-effective method to protect extraction sites in laparoscopic colorectal procedures?

Science.gov (United States)

Huynh, Hai P; Musselman, Reilly P; Trottier, Daniel C; Soto, Claudia M; Poulin, Eric C; Mamazza, Joseph; Boushey, Robin P; Auer, Rebecca C; Moloo, Husein

2013-10-01

To review surgical-site infection (SSI) and retrieval-site tumor recurrence rates in laparoscopic colorectal procedures when using a plastic freezer bag as a wound protector. Laparoscopic colorectal procedures where a plastic freezer bag used as a wound protector at the extraction site were reviewed between 1991 and 2008 from a prospectively collected database. χ test was used to compare SSI and tumor recurrence rates between groups. Costing data were obtained from the operating room supplies department. A total of 936 cases with 51 (5.45%) surgical-site infections were identified. SSI rates did not differ when comparing groups based on demographic factors, diagnosis, or location of procedure. Retrieval-site tumor recurrence rate was 0.21% (1/474). Cost of plastic freezer bags including sterilization ranged from $0.25 to $3. Plastic freezer bags as wound protectors in laparoscopic colorectal procedures are cost effective and have SSI and retrieval-site tumor recurrence rates that compare favorably to published data.

Study protocol of cost-effectiveness and cost-utility of a biopsychosocial multidisciplinary intervention in the evolution of non-specific sub-acute low back pain in the working population: cluster randomised trial

Directory of Open Access Journals (Sweden)

de Kort Nelleke

2011-08-01

Full Text Available Abstract Background Low back pain (LBP, with high incidence and prevalence rate, is one of the most common reasons to consult the health system and is responsible for a significant amount of sick leave, leading to high health and social costs. The objective of the study is to assess the cost-effectiveness and cost-utility analysis of a multidisciplinary biopsychosocial educational group intervention (MBEGI of non-specific sub-acute LBP in comparison with the usual care in the working population recruited in primary healthcare centres. Methods/design The study design is a cost-effectiveness and cost-utility analysis of a MBEGI in comparison with the usual care of non-specific sub-acute LBP. Measures on effectiveness and costs of both interventions will be obtained from a cluster randomised controlled clinical trial carried out in 38 Catalan primary health care centres, enrolling 932 patients between 18 and 65 years old with a diagnosis of non-specific sub-acute LBP. Effectiveness measures are: pharmaceutical treatments, work sick leave (% and duration in days, Roland Morris disability, McGill pain intensity, Fear Avoidance Beliefs (FAB and Golberg Questionnaires. Utility measures will be calculated from the SF-12. The analysis will be performed from a social perspective. The temporal horizon is at 3 months (change to chronic LBP and 12 months (evaluate the outcomes at long term. Assessment of outcomes will be blinded and will follow the intention-to-treat principle. Discussion We hope to demonstrate the cost-effectiveness and cost-utility of MBEGI, see an improvement in the patients' quality of life, achieve a reduction in the duration of episodes and the chronicity of non-specific low back pain, and be able to report a decrease in the social costs. If the intervention is cost-effectiveness and cost-utility, it could be applied to Primary Health Care Centres. Trial registration ISRCTN: ISRCTN58719694

76 FR 5365 - Environmental Management Site-Specific Advisory Board, Nevada

Science.gov (United States)

2011-01-31

... Industrial Sites and Soils Committees of the Environmental Management Site-Specific Advisory Board (EM SSAB... sites at the Nevada National Security Site including decontamination, closure, re-use and/or demolition. Purpose of the Soils Committee: The purpose of the Committee is to focus on issues related to soil...

75 FR 71677 - Environmental Management Site-Specific Advisory Board, Nevada

Science.gov (United States)

2010-11-24

... Industrial Sites and Soils Committees of the Environmental Management Site-Specific Advisory Board (EM SSAB... sites at the Nevada Test Site including decontamination, closure, re-use and/or demolition. Purpose of the Soils Committee: The purpose of the Committee is to focus on issues related to soil contamination...

Shifting the Paradigm for Long Term Monitoring at Legacy Sites to Improve Performance while Reducing Cost

International Nuclear Information System (INIS)

Eddy-Dilek, Carol A.; Looney, Brian B.; Seaman, John; Kmetz, Thomas

2013-01-01

A major issue facing many government and private industry sites that were previously contaminated with radioactive and chemical wastes is that often the sites cannot be cleaned up enough to permit unrestricted human access. These sites will require long-term management, in some cases indefinitely, leaving site owners with the challenge of protecting human health and environmental quality in a cost effective manner. Long-term monitoring of groundwater contamination is one of the largest projected costs in the life cycle of environmental management at the Savannah River Site (SRS), the larger DOE complex, and many large federal and private sites. Currently, most monitoring strategies are focused on laboratory measurements of contaminants measured in groundwater samples collected from wells. This approach is expensive, and provides limited and lagging information about the effectiveness of cleanup activities and the behavior of the residual contamination. Over the last twenty years, DOE and other federal agencies have made significant investments in the development of various types of sensors and strategies that would allow for remote analysis of contaminants in groundwater, but these approaches do not promise significant reductions in risk or cost. Scientists at SRS have developed a new paradigm to simultaneously improve the performance of long term monitoring systems while lowering the overall cost of monitoring. This alternative approach incorporates traditional point measurements of contaminant concentration with measurements of controlling variables including boundary conditions, master variables, and traditional plume/contaminant variables. Boundary conditions are the overall driving forces that control plume movement and therefore provide leading indication to changes in plume stability. These variables include metrics associated with meteorology, hydrology, hydrogeology, and land use. Master variables are the key variables that control the chemistry of the

1994 INEL site-specific plan

International Nuclear Information System (INIS)

Couch, B.

1994-01-01

This report presents plans for environmental restoration and waste management activities at the Idaho National Engineering Laboratory for fiscal year 1994. This years's plan focuses on issues affecting the Environmental Restoration and Waste Management Programs. The Environmental Restoration Program is concerned with all aspects of assessment and cleanup of inactive operations. It involves assessing and cleaning up (where necessary) inactive INEL waste areas that could release harmful substances into the environment, as well as safely managing surplus nuclear facilities. The Waste Management program involves treatment, storage, and disposal of radioactive, hazardous, mixed, and industrial waste by DOE activities. This program is designed to protect the safety of INEL employees, the public, and the environment in the design, construction, maintenance, and operation of INEL treatment, storage, and disposal facilities. It operates facilities in a cost-effective, environmentally sound, regulatory compliant, and publicly acceptable manner

Environmental Restoration and Waste Management Site-Specific Plan (SSP) for fiscal year 1992 (FY92)

International Nuclear Information System (INIS)

1991-09-01

The FY-92 Site-Specific Plan (FY-92 SSP) for environmental restoration and waste management at the Idaho National Engineering Laboratory (INEL) is designed to provide the reader with easy access to the status of environmental restoration and waste management activities at INEL. The first chapter provides background on INIEL's physical environment, site history and mission, and general information about the site and its facilities. In addition, this chapter discusses the inter-relationships between the Site Specific Plan, the Environmental Restoration and Waste Management Five-Year Plan, the environmental restoration and waste management prioritization systems, and the Activity Data Sheets (ADSs) for environmental restoration and waste management. This discussion should help readers understand what the SSP is and how it fits into the environmental restoration and waste management process at INEL. This understanding should provide the reader with a better context for understanding the discussions in the SSP as well as a better feel for how and what to comment on during the public comment period that will be held from the first of September through the end of October 1991

Design Study for A Low-Cost LH2 Turbopump

Science.gov (United States)

Japikse, David; Baines, Nicholas; Platt, Michael J.

2000-01-01

A preliminary design study, focusing on potential component selections and design for manufacturing and assembly (DFMAR1) analysis, is presented in this study. The investigation focused on a nominal cost liquid hydrogen turbopump suitable for a private launch class vehicle. Utilizing a "turbocharger-like" design philosophy, preliminary feasibility studies of the basic pump design class, the rotordynamic design class, and the turbine design class were conducted with associated DFMA evaluations. Reasonable cost levels and sensible levels of product assurance have been established.

Innovative Feed-In Tariff Designs that Limit Policy Costs

Energy Technology Data Exchange (ETDEWEB)

Kreycik, C.; Couture, T. D.; Cory, K. S.

2011-06-01

Feed-in tariffs (FITs) are the most prevalent renewable energy policy used globally to date, and there are many benefits to the certainty offered in the marketplace to reduce development risks and associated financing costs and to grow the renewable energy industry. However, concerns over escalating costs in jurisdictions with FIT policies have led to increased attention on cost control in renewable energy policy design. In recent years, policy mechanisms for containing FIT costs have become more refined, allowing policymakers to exert greater control on policy outcomes and on the resulting costs to ratepayers. As policymakers and regulators in the United States begin to explore the use of FITs, careful consideration must be given to the ways in which policy design can be used to balance the policies' advantages while bounding its costs. This report explores mechanisms that policymakers have implemented to limit FIT policy costs. If designed clearly and transparently, such mechanisms can align policymaker and market expectations for project deployment. Three different policy tools are evaluated: (1) caps, (2) payment level adjustment mechanisms, and (3) auction-based designs. The report employs case studies to explore the strengths and weaknesses of these three cost containment tools. These tools are then evaluated with a set of criteria including predictability for policymakers and the marketplace and the potential for unintended consequences.

Applied field test procedures on petroleum release sites

International Nuclear Information System (INIS)

Gilbert, G.; Nichols, L.

1995-01-01

The effective remediation of petroleum contaminated soils and ground water is a significant issue for Williams Pipe Line Co. (Williams): costing $6.8 million in 1994. It is in the best interest, then, for Williams to adopt approaches and apply technologies that will be both cost-effective and comply with regulations. Williams has found the use of soil vapor extraction (SVE) and air sparging (AS) field test procedures at the onset of a petroleum release investigation/remediation accomplish these goals. This paper focuses on the application of AS/SVE as the preferred technology to a specific type of remediation: refined petroleum products. In situ field tests are used prior to designing a full-scale remedial system to first validate or disprove initial assumptions on applicability of the technology. During the field test, remedial system design parameters are also collected to tailor the design and operation of a full-scale system to site specific conditions: minimizing cost and optimizing effectiveness. In situ field tests should be designed and operated to simulate as close as possible the operation of a full-scale remedial system. The procedures of an in situ field test will be presented. The results of numerous field tests and the associated costs will also be evaluated and compared to full-scale remedial systems and total project costs to demonstrate overall effectiveness. There are many advantages of As/SVE technologies over conventional fluid extraction or SVE systems alone. However, the primary advantage is the ability to simultaneously reduce volatile and biodegradable compound concentrations in the phreatic, capillary fringe, and unsaturated zones

Risk management study for the Hanford Site facilities: Risk reduction cost comparison for the retired Hanford Site facilities. Volume 4

Energy Technology Data Exchange (ETDEWEB)

Coles, G.A.; Egge, R.G.; Senger, E.; Shultz, M.W.; Taylor, W.E.

1994-02-01

This document provides a cost-comparison evaluation for implementing certain risk-reduction measures and their effect on the overall risk of the 100 and 200 Area retired, surplus facilities. The evaluation is based on conditions that existed at the time the risk evaluation team performed facility investigations, and does not acknowledge risk-reduction measures that occurred soon after risk identification. This evaluation is one part of an overall risk management study for these facilities. The retired facilities investigated for this evaluation are located in the 100 and 200 Areas of the 1450-km{sup 2} Hanford Site. The Hanford Site is a semiarid tract of land in southeastern Washington State. The nearest population center is Richland, Washington, (population 32,000) 30 km southeast of the 200 Area. This cost-comparison evaluation (1) determines relative costs for reducing risk to acceptable levels; (2) compares the cost of reducing risk using different risk-reduction options; and (3) compares the cost of reducing risks at different facilities. The result is an identification of the cost effective risk-reduction measures. Supporting information required to develop costs of the various risk-reduction options also is included.

Improved Cost-Base Design of Water Distribution Networks using Genetic Algorithm

Science.gov (United States)

Moradzadeh Azar, Foad; Abghari, Hirad; Taghi Alami, Mohammad; Weijs, Steven

2010-05-01

Population growth and progressive extension of urbanization in different places of Iran cause an increasing demand for primary needs. The water, this vital liquid is the most important natural need for human life. Providing this natural need is requires the design and construction of water distribution networks, that incur enormous costs on the country's budget. Any reduction in these costs enable more people from society to access extreme profit least cost. Therefore, investment of Municipal councils need to maximize benefits or minimize expenditures. To achieve this purpose, the engineering design depends on the cost optimization techniques. This paper, presents optimization models based on genetic algorithm(GA) to find out the minimum design cost Mahabad City's (North West, Iran) water distribution network. By designing two models and comparing the resulting costs, the abilities of GA were determined. the GA based model could find optimum pipe diameters to reduce the design costs of network. Results show that the water distribution network design using Genetic Algorithm could lead to reduction of at least 7% in project costs in comparison to the classic model. Keywords: Genetic Algorithm, Optimum Design of Water Distribution Network, Mahabad City, Iran.

77 FR 22772 - Environmental Management Site-Specific Advisory Board

Science.gov (United States)

2012-04-17

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board AGENCY: Office of Environmental Management, Department of Energy. ACTION: Notice of renewal. SUMMARY: Pursuant to Section 14(a)(2... Secretariat, General Services Administration, notice is hereby given that the Environmental Management Site...

Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Rifle, Colorado

International Nuclear Information System (INIS)

1990-02-01

This document has been structured to provide a comprehensive understanding of the remedial action proposed for the Rifle sites. That remedial action consists of removing approximately 4,185,000 cubic yards (cy) of tailings and contaminated materials from their current locations, transporting, and stabilizing the tailings material at the Estes Gulch disposal site, approximately six miles north of Rifle. The tailings and contaminated materials are comprised of approximately 597,000 cy from Old Rifle, 3,232,000 cy from New Rifle, and 322,000 cy from vicinity properties and about 34,000 cy from demolition. The remedial action plan includes specific design requirements for the detailed design and construction of the remedial action. An extensive amount of data and supporting information have been generated for this remedial action and cannot all be incorporated into this document. Pertinent information and data are included with reference given to the supporting documents

Can the benefits of physical seabed restoration justify the costs? An assessment of a disused aggregate extraction site off the Thames Estuary, UK.

Science.gov (United States)

Cooper, Keith; Burdon, Daryl; Atkins, Jonathan P; Weiss, Laura; Somerfield, Paul; Elliott, Michael; Turner, Kerry; Ware, Suzanne; Vivian, Chris

2013-10-15

Physical and biological seabed impacts can persist long after the cessation of marine aggregate dredging. Whilst small-scale experimental studies have shown that it may be possible to mitigate such impacts, it is unclear whether the costs of restoration are justified on an industrial scale. Here we explore this question using a case study off the Thames Estuary, UK. By understanding the nature and scale of persistent impacts, we identify possible techniques to restore the physical properties of the seabed, and the costs and the likelihood of success. An analysis of the ecosystem services and goods/benefits produced by the site is used to determine whether intervention is justified. Whilst a comparison of costs and benefits at this site suggests restoration would not be warranted, the analysis is site-specific. We emphasise the need to better define what is, and is not, an acceptable seabed condition post-dredging. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

Aerodynamic Optimization of a Wind Turbine Blade Designed for Egypt's Saharan Environment Using a Genetic Algorithm

Directory of Open Access Journals (Sweden)

Khaled Yassin

2015-08-01

Full Text Available This work aims to optimize the aerodynamic parameters (airfoil chord lengths and twist angles smoothed using Bezier curves of the NREL 5MW wind turbine and a wind turbine designed for site-specific wind conditions to increase the wind turbine's annual energy production (AEP under this site conditions. This optimization process is carried out using a Genetic Algorithm (GA developed in MATLAB and coupled with NREL's FAST Modularization Framework. The results shows that after optimizing the NREL 5MW wind turbine design, the AEP was improved by 5.9% of the baseline design AEP while a site-specific designed wind turbine using Schmitz equations shows 1.2% improvement in AEP. These results shows that optimization of wind turbine blade aerodynamic parameters for site-specific wind conditions leads to improvement in AEP and hence decreasing cost of energy generated by wind turbines.

Overview of SDCM - The Spacecraft Design and Cost Model

Science.gov (United States)

Ferebee, Melvin J.; Farmer, Jeffery T.; Andersen, Gregory C.; Flamm, Jeffery D.; Badi, Deborah M.

1988-01-01

The Spacecraft Design and Cost Model (SDCM) is a computer-aided design and analysis tool for synthesizing spacecraft configurations, integrating their subsystems, and generating information concerning on-orbit servicing and costs. SDCM uses a bottom-up method in which the cost and performance parameters for subsystem components are first calculated; the model then sums the contributions from individual components in order to obtain an estimate of sizes and costs for each candidate configuration within a selected spacecraft system. An optimum spacraft configuration can then be selected.

Fusion reactor design studies: standard accounts for cost estimates

International Nuclear Information System (INIS)

Schulte, S.C.; Willke, T.L.; Young, J.R.

1978-05-01

The fusion reactor design studies--standard accounts for cost estimates provides a common format from which to assess the economic character of magnetically confined fusion reactor design concepts. The format will aid designers in the preparation of design concept costs estimates and also provide policymakers with a tool to assist in appraising which design concept may be economically promising. The format sets forth a categorization and accounting procedure to be used when estimating fusion reactor busbar energy cost that can be easily and consistently applied. Reasons for developing the procedure, explanations of the procedure, justifications for assumptions made in the procedure, and the applicability of the procedure are described in this document. Adherence to the format when evaluating prospective fusion reactor design concepts will result in the identification of the more promising design concepts thus enabling the fusion power alternatives with better economic potential to be quickly and efficiently developed

Technical specifications for the Pajarito Site Critical Experiments Facility

International Nuclear Information System (INIS)

Malenfant, R.E.; Paxton, H.C.

1980-12-01

This document is to satisfy the requirement for technical specifications spelled out in DOE Manual Chapter 0540, Safety of DOE-Owned Reactors. Technical specifications are defined in Sec. 0540-048, and the requirement for them appears in Sec. 0540-015. The following technical specifications update the document, Technical Specifications for the Pajarito Site Critical Experiments Facility

Cost benefit of caustic recycle for tank waste remediation at the Hanford and Savannah River Sites

International Nuclear Information System (INIS)

DeMuth, S.

1998-01-01

The potential cost savings due to the use of caustic recycle used in conjunction with remediation of radioactive underground storage tank waste, is shown in a figure for the Hanford and Savannah River sites. Two cost savings estimates for each case have been made for Hanford, and one cost savings estimate for each case have been made for Hanford, and one cost savings estimate for each case has been made for the Savannah River site. This is due to the Hanford site remediation effort being less mature than that of Savannah River; and consequently, a range of cost savings being more appropriate for Hanford. This range of cost savings (rather than a ingle value) for each case at Hanford is due to cost uncertainties related to the LAW immobilization operation. Caustic recycle Case-1 has been defined as the sodium required to meet al identified caustic needs for the entire Site. Case-2 has been defined as the maximum sodium which can be separated from the low activity waste without precipitation of Al(OH) 3 . It has been determined that the potential cost savings at Hanford ranges from $194 M to $215 M for Case-1, and $293 M to $324 M for Case-2. The potential cost savings at Savannah River are $186 M for Case-1 and $281 M for Case-2. A discussion of the uncertainty associated with these cost savings estimates can be found in the Discussion and Conclusions section

1994 INEL site-specific plan

Energy Technology Data Exchange (ETDEWEB)

Couch, B.

1994-05-01

This report presents plans for environmental restoration and waste management activities at the Idaho National Engineering Laboratory for fiscal year 1994. This years`s plan focuses on issues affecting the Environmental Restoration and Waste Management Programs. The Environmental Restoration Program is concerned with all aspects of assessment and cleanup of inactive operations. It involves assessing and cleaning up (where necessary) inactive INEL waste areas that could release harmful substances into the environment, as well as safely managing surplus nuclear facilities. The Waste Management program involves treatment, storage, and disposal of radioactive, hazardous, mixed, and industrial waste by DOE activities. This program is designed to protect the safety of INEL employees, the public, and the environment in the design, construction, maintenance, and operation of INEL treatment, storage, and disposal facilities. It operates facilities in a cost-effective, environmentally sound, regulatory compliant, and publicly acceptable manner.

Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Durango, Colorado: Attachment 2, Geology report. Revised final report

Energy Technology Data Exchange (ETDEWEB)

1991-12-01

Detailed investigations of geologic, geomorphic, and seismic conditions at the Bodo Canyon disposal site were conducted. The purpose of these investigations was basic site characterization and identification of potential geologic hazards that could affect long-term site stability. Subsequent engineering studies, such as analyses of hydrologic and liquefaction hazards, used the data developed in these studies. The geomorphic analysis was employed in the design of effective erosion protection. Studies of the regional and local seismotectonic setting, which included a detailed search for possible capable faults within a 65 kilometer radius of the site, provided the basis for seismic design parameters. The scope of work performed included the following: Compilation and analysis of previous published and unpublished geologic literature and maps; Review of historical and instrumental earthquake data; Review of site-specific subsurface geologic data, including lithologic and geophysical logs of exploratory boreholes advanced in the site area; Photogeologic interpretations of existing conventional aerial photographs; and, Ground reconnaissance and mapping of the site region.

Precision farming - Technology assessment of site-specific input application in cereals

DEFF Research Database (Denmark)

Pedersen, Søren Marcus

economic and socio-economic analysis. The current status of precision farming in Denmark is as follows: • The technology is primarily applicable for large farm holdings • Economic viability depends on site-specific yield variation • So far, the business economic benefits from most PF-practices are modest...... but it seems possible to obtain a socio-economic benefits from lime, variable rate herbicide and possibly nitrogen application • The technology may improve farm logistics, planning and crop quality (e.g. protein content) - but • The costs of implementing PF-practices are high and • Technical functionality...... several years before the next generation of precision farming systems will be available in practice. Meanwhile, those farmers who already have invested in yield monitors and soil analysis for precision farming should be able to use the current technology in the best possible way....

Designation of facility usage categories for Hanford Site facilities

International Nuclear Information System (INIS)

Woodrich, D.D.; Ellingson, D.R.; Scott, M.A.; Schade, A.R.

1991-10-01

This report summarizes the Hanford Site methodology used to ensure facility compliance with the natural phenomena design criteria set forth in the US Department of Energy Orders and guidance. The current Hanford Site methodology for Usage Category designation is based on an engineered feature's safety function and on the feature's assigned Safety Class. At the Hanford Site, Safety Class assignments are deterministic in nature and are based on teh consequences of failure, without regard to the likelihood of occurrence. The report also proposes a risk-based approach to Usage Category designation, which is being considered for future application at the Hanford Site. To establish a proper Usage Category designation, the safety analysis and engineering design processes must be coupled. This union produces a common understanding of the safety function(s) to be accomplished by the design feature(s) and a sound basis for the assignment of Usage Categories to the appropriate systems, structures, and components. 4 refs., 9 figs., 1 tab

Appreciating Site-Specific Qualities in Urban Harbours

DEFF Research Database (Denmark)

Reeh, Henrik

2015-01-01

of observa-tions from Marseille in southern France. After modernization and dislocation of its harbor territories in the early 20th century already, this city is currently taking important steps from industrial urbanism into cultural planning. This transformation allows for new and unprogrammed experiences......When “site-specificity” becomes a central value in city and harbor transformation, it soon proves necessary to address the ways in which scholars and professionals actually determine site-specific qualities in urban fabrics and social life. This paper delves into the above questions by means...

Forum on specification and Design Languages

CERN Document Server

Maehne, Torsten

2015-01-01

This book brings together a selection of the best papers from the sixteenth edition of the Forum on specification and Design Languages Conference (FDL), which was held in September 2013 in Paris, France. FDL is a well-established international forum devoted to dissemination of research results, practical experiences and new ideas in the application of specification, design and verification languages to the design, modeling and verification of integrated circuits, complex hardware/software embedded systems, and mixed-technology systems. • Covers applications of formal methods for specification, verification and debug; • Includes embedded analog and mixed-signal system design; • Enables model-driven engineering for embedded systems design and development.

Using proven, cost-effective chemical stabilization to remediate radioactive and heavy metal contaminated sites

International Nuclear Information System (INIS)

Jensen, R.; Sogue, A.

1999-01-01

Rocky Mountain Remediation Services, L.L.C. (RMRS) has deployed a cost-effective metals stabilization method which can be used to reduce the cost of remediation projects where radioactivity and heavy metals are the contaminants of concern. The Envirobond TM process employs the use of a proprietary chemical process to stabilize metals in many waste forms, and provides an excellent binding system that can easily be compacted to reduce the waste into a shippable brick called Envirobric TM . The advantages of using chemical stabilization are: (1) Low cost, due to the simplicity of the process design and inexpensive reagents. (2) Chemical stabilization is easily deployed in field applications, which limit the amount of shielding and other protective measures. (3) The process does not add volume and bulk to the treated waste; after treatment the materials may be able to remain on-site, or if transportation and disposal is required the cost will be reduced due to lower volumes. (4) No secondary waste. The simplicity of this process creates a safe environment while treating the residues, and the long-term effectiveness of this type of chemical stabilization lowers the risk of future release of hazardous elements associated with the residues. (author)

Exploratory shaft conceptual design report: Gulf Interior Region salt domes

International Nuclear Information System (INIS)

1983-07-01

This conceptual design report summarizes the conceptualized design for an exploratory shaft facility at a representative site in the Gulf Interior Region of the United States (Louisiana and Mississippi). Conceptualized designs for other possible locations (Paradox Basin in Utah and Permian Basin in Texas) are summarized in separate reports. The purpose of the exploratory shaft facility is to provide access to the reference repository horizon to permit in-situ testing of the salt. The in-situ testing is necessary to verify repository salt design parameters, evaluate isotropy and homoqeneity of the salt, and provide a demonstration of the constructability and confirmation of the design to gain access to the repository. The fundamental purpose of this conceptual design report is to assure the feasibility of the exploratory shaft project and to develop a reliable cost estimate and realistic schedule. Because a site has not been selected and site-specific subsurface data are not available, it has been necessary to make certain assumptions in order to develop a conceptural design for an exploratory shaft facility in salt. As more definitive information becomes available to support the design process, adjustments in the projected schedule and estimated costs will be required

Experimental site and design

Energy Technology Data Exchange (ETDEWEB)

Guenette, C. C. [SINTEF Applied Cemistry, Trondheim (Norway)

1999-08-01

Design and site selection criteria for the Svalbard oil spill experiments are described. All three experimental sites have coarse and mixed sediment beaches of sand and pebble; within each site wave exposure is very similar; along-shore and across-shore sediment characteristics are also relatively homogeneous. Tidal range is in the order of 0.6 m at neaps, and 1.8 m at springs. All three sites are open to wave action and are ice-free during the experimental period of mid-July to mid-October. Study plots at each site were selected for different treatments from within the continuous stretch of oiled shoreline, with oiled buffer zones between plots and at either end of the oiled zone. Treatments included mixing (tilling), sediment relocation (surf washing) and bioremediation (nutrient enrichment). Measurements and observations were carried out during the summers of 1997 and 1998. The characteristics measured were: wave and wind conditions; beach topography and elevation; sediment grain size distribution; mineral fines size distribution and mineral composition; background hydrocarbons; concentration of oil within experimental plots and the rate of oil loss over time; depth of oil penetration and thickness of the oiled sediment layer; oil concentration and toxicity of near-shore benthic sediments; mineral composition of suspended particulate material captured in sub-tidal sediment traps; and oil-fines interaction in near-shore water samples. 1 fig.

Experimental site and design

Energy Technology Data Exchange (ETDEWEB)

Guenette, C. C. [SINTEF Applied Cemistry, Trondheim (Norway)

1999-07-01

Design and site selection criteria for the Svalbard oil spill experiments are described. All three experimental sites have coarse and mixed sediment beaches of sand and pebble; within each site waveexposure is very similar; along-shore and across-shore sediment characteristics are also relatively homogeneous. Tidal range is in the order of 0.6 m at neaps, and 1.8 m at springs. All three sites are open to wave action and are ice-free during the experimental period of mid-July to mid-October. Study plots at each site were selected for different treatments from within the continuous stretch of oiled shoreline, with oiled buffer zones between plots and at either end of the oiled zone. Treatments included mixing (tilling), sediment relocation (surf washing) and bioremediation (nutrient enrichment). Measurements and observations were carried out during the summers of 1997 and 1998. The characteristics measured were: wave and wind conditions; beach topography and elevation; sediment grain size distribution; mineral fines size distribution and mineral composition; background hydrocarbons; concentration of oil within experimental plots and the rate of oil loss over time; depth of oil penetration and thickness of the oiled sediment layer; oil concentration and toxicity of near-shore benthic sediments; mineral composition of suspended particulate material captured in sub-tidal sediment traps; and oil-fines interaction in near-shore water samples. 1 fig.

On site clean up with a hazardous waste incinerator

International Nuclear Information System (INIS)

Cross, F.L. Jr.; Tessitore, J.L.

1987-01-01

The Army Corps of Engineers and the EPA have determined that on-site incineration for the detoxification of soils, sediments, and sludges is a viable, safe, and economic alternative. This paper discusses an approach to on-site incineration as a method of detoxification of soils/sediments contaminated with organic hazardous wastes. Specifically, this paper describes the procedures used to evaluate on-site incineration at a large Superfund site with extensive PCB contaminated soils and sediments. The paper includes the following: (1) a discussion of site waste quantities and properties, (2) a selection of an incineration technology with a resulting concept and design, (3) a discussion of incinerator permitting requirements, (4) discussion and rationale for an incinerator sub-scale testing approach, and (5) analysis of on-site incineration cost

Pinellas Plant FY1990 site specific implementation plan

International Nuclear Information System (INIS)

Klein, R.D.

1990-02-01

This Site Specific Implementation Plan describes the Corrective Action, Environmental Restoration, and Waste Management activities to be performed at the Pinellas Plant in FY1990 (October 1, 1989 to September 30, 1989). These FY1990 activities are described in the Pinellas Plant FY1991--95 Five-Year Plan. The information used to prepare this plan reflects the best estimate of the project scope, schedules, regulatory, and funding requirements at the time of plan preparation. The Environmental Restoration/Waste Management Five-Year Plan is a dynamic document and will be modified each year; the Site Specific Implementation Plan will, in turn, be modified each year to reflect new findings, information, and knowledge of the various projects. 4 figs., 11 tabs

Unusual Structure of the attB Site of the Site-Specific Recombination System of Lactobacillus delbrueckii Bacteriophage mv4

Science.gov (United States)

Auvray, Frédéric; Coddeville, Michèle; Ordonez, Romy Catoira; Ritzenthaler, Paul

1999-01-01

The temperate phage mv4 integrates its genome into the chromosome of Lactobacillus delbrueckii subsp. bulgaricus by site-specific recombination within the 3′ end of a tRNASer gene. Recombination is catalyzed by the phage-encoded integrase and occurs between the phage attP site and the bacterial attB site. In this study, we show that the mv4 integrase functions in vivo in Escherichia coli and we characterize the bacterial attB site with a site-specific recombination test involving compatible plasmids carrying the recombination sites. The importance of particular nucleotides within the attB sequence was determined by site-directed mutagenesis. The structure of the attB site was found to be simple but rather unusual. A 16-bp DNA fragment was sufficient for function. Unlike most genetic elements that integrate their DNA into tRNA genes, none of the dyad symmetry elements of the tRNASer gene were present within the minimal attB site. No inverted repeats were detected within this site either, in contrast to the lambda site-specific recombination model. PMID:10572145

Remediation alternatives and costs for the restoration of MGP sites. Topical report, May 1990. Documentation

International Nuclear Information System (INIS)

1990-03-01

The Gas Research Institute (GRI) has embarked on a multi-year program to address the Management of Manufactured Gas Plant (MGP) Sites. The program focuses on three primary technical areas: site investigation, risk assessment, and site restoration. Program activities in each of these areas are separated into two phases. Phase 1 emphasizes the identification, collation, and analysis of the state-of-the-art applicable to specific MGP site situations. Phase 2 involves the generation of data through targeted research and development projects. The second phase of the program is producing a series of topical reports, such as this one, from laboratory and field experimental test programs. These programs are designed to fill data gaps required for the effective management of these sites and to advance the state-of-the-art for technologies determined during Phase 1 as potentially applicable to MGP site wastes. Other reports from the second phase will continue to be produced through 1991 as various portions of the program are completed

Are Biophilic-Designed Site Office Buildings Linked to Health Benefits and High Performing Occupants?

Directory of Open Access Journals (Sweden)

Tonia Gray

2014-11-01

Full Text Available This paper discusses the first phase of a longitudinal study underway in Australia to ascertain the broad health benefits of specific types of biophilic design for workers in a building site office. A bespoke site design was formulated to include open plan workspace, natural lighting, ventilation, significant plants, prospect and views, recycled materials and use of non-synthetic materials. Initial data in the first three months was gathered from a series of demographic questions and from interviews and observations of site workers. Preliminary data indicates a strong positive effect from incorporating aspects of biophilic design to boost productivity, ameliorate stress, enhance well-being, foster a collaborative work environment and promote workplace satisfaction, thus contributing towards a high performance workspace. The longitudinal study spanning over two years will track human-plant interactions in a biophilic influenced space, whilst also assessing the concomitant cognitive, social, psychological and physical health benefits for workers.

Design Specifications for Adaptive Real-Time Systems

Science.gov (United States)

1991-12-01

TICfl \\ E CT E Design Specifications for JAN’\\ 1992 Adaptive Real - Time Systems fl Randall W. Lichota U, Alice H. Muntz - December 1991 \\ \\\\/ 0 / r...268-2056 Technical Report CMU/SEI-91-TR-20 ESD-91-TR-20 December 1991 Design Specifications for Adaptive Real - Time Systems Randall W. Lichota Hughes...Design Specifications for Adaptive Real - Time Systems Abstract: The design specification method described in this report treats a software

Occupational radiation dose assessment for a non site specific spent fuel storage facility

International Nuclear Information System (INIS)

Hadley, J.; Eble, R.G. Jr.

1997-01-01

To expedite the licensing process of the non site specific Centralized Interim Storage Facility (CISF) the Department of Energy has completed a phase I CISF Topical Safety Analysis Report (TSAR). The TSAR will be used in licensing the phase I CISF if a site is designated. An occupational radiation does assessment of the facility operations is performed as part of the phase I CISF design. The first phase of the CISF has the capability to receive, transfer, and store SNF in dual-purpose cask/canister systems (DPC's). Currently there are five vendor technologies under consideration. The preliminary dose assessment is based on estimated occupational exposures using traditional power plant ISFSI and transport cask handling processes. The second step in the process is to recommend ALARA techniques to reduce potential exposures. A final dose assessment is completed implementing the ALARA techniques and a review is performed to ensure that the design is in compliance with regulatory criteria. The dose assessment and ALARA evaluation are determined using the following input information: Dose estimates from vendor SAR's; ISFSI experience with similar systems; Traditional methods of operations; Expected CISF cask receipt rates; and feasible ALARA techniques. 5 refs., 1 tab

Using the Textpresso Site-Specific Recombinases Web server to identify Cre expressing mouse strains and floxed alleles.

Science.gov (United States)

Condie, Brian G; Urbanski, William M

2014-01-01

Effective tools for searching the biomedical literature are essential for identifying reagents or mouse strains as well as for effective experimental design and informed interpretation of experimental results. We have built the Textpresso Site Specific Recombinases (Textpresso SSR) Web server to enable researchers who use mice to perform in-depth searches of a rapidly growing and complex part of the mouse literature. Our Textpresso Web server provides an interface for searching the full text of most of the peer-reviewed publications that report the characterization or use of mouse strains that express Cre or Flp recombinase. The database also contains most of the publications that describe the characterization or analysis of strains carrying conditional alleles or transgenes that can be inactivated or activated by site-specific recombinases such as Cre or Flp. Textpresso SSR complements the existing online databases that catalog Cre and Flp expression patterns by providing a unique online interface for the in-depth text mining of the site specific recombinase literature.

ETAC reagents: A new class of sulfhydryl site-specific radiolabelling probes for antibodies

International Nuclear Information System (INIS)

del Rosario, R.B.; Brocchini, S.J.; Baron, L.A.; Smith, R.H.; Lawton, R.G.; Wahl, R.L.

1990-01-01

A new class of bis-alkylating Michael reagents, equilibrium transfer crosslink reagents, 'ETAC', which combine the techniques of crosslinking with tethering have been synthesized. Following a succession of Michael and retro-Michael additions and elimination of the arylsulfone groups, reduced heavy-heavy and heavy-light disulfide links of an anti-ovarian IgG2a monoclonal antibody, 5G6.4, were site-specifically re-annealed via a 3-carbon bridge having a tether branch containing a designated label

Using maximum entropy modeling for optimal selection of sampling sites for monitoring networks

Science.gov (United States)

Stohlgren, Thomas J.; Kumar, Sunil; Barnett, David T.; Evangelista, Paul H.

2011-01-01

Environmental monitoring programs must efficiently describe state shifts. We propose using maximum entropy modeling to select dissimilar sampling sites to capture environmental variability at low cost, and demonstrate a specific application: sample site selection for the Central Plains domain (453,490 km2) of the National Ecological Observatory Network (NEON). We relied on four environmental factors: mean annual temperature and precipitation, elevation, and vegetation type. A “sample site” was defined as a 20 km × 20 km area (equal to NEON’s airborne observation platform [AOP] footprint), within which each 1 km2 cell was evaluated for each environmental factor. After each model run, the most environmentally dissimilar site was selected from all potential sample sites. The iterative selection of eight sites captured approximately 80% of the environmental envelope of the domain, an improvement over stratified random sampling and simple random designs for sample site selection. This approach can be widely used for cost-efficient selection of survey and monitoring sites.

Design, construction, and analysis of specific zinc finger nucleases for microphthalmia - associate transcription factor

Directory of Open Access Journals (Sweden)

Wenwen Wang

2012-08-01

Full Text Available This work studied the design, construction, and cleavage analysis of zinc finger nucleases (ZFNs that could cut the specific sequences within microphthalmia - associate transcription factor (mitfa of zebra fish. The target site and ZFPs were selected and designed with zinc finger tools, while the ZFPs were synthesized using DNAWorks and two-step PCR. The ZFNs were constructed, expressed, purified, and analyzed in vitro. As expected, the designed ZFNs could create a double-stand break (DSB at the target site in vitro. The DNAWorks, two-step PCR, and an optimized process of protein expression were firstly induced in the construction of ZFNs successfully, which was an effective and simplified protocol. These results could be useful for further application of ZFNs - mediated gene targeting.

76 FR 51029 - Proposed CERCLA Administrative Cost Recovery Settlement; Carpenter Avenue Mercury Site, Iron...

Science.gov (United States)

2011-08-17

... Settlement; Carpenter Avenue Mercury Site, Iron Mountain, Dickenson County, MI AGENCY: Environmental... of past response costs concerning the Carpenter Avenue Mercury site in Iron Mountain, Dickenson...., mail code: C-14J, Chicago, Illinois 60604. Comments should reference the Carpenter Avenue Mercury site...

Econometric estimation of WHO-CHOICE country-specific costs for inpatient and outpatient health service delivery.

Science.gov (United States)

Stenberg, Karin; Lauer, Jeremy A; Gkountouras, Georgios; Fitzpatrick, Christopher; Stanciole, Anderson

2018-01-01

Policy makers require information on costs related to inpatient and outpatient health services to inform resource allocation decisions. Country data sets were gathered in 2008-2010 through literature reviews, website searches and a public call for cost data. Multivariate regression analysis was used to explore the determinants of variability in unit costs using data from 30 countries. Two models were designed, with the inpatient and outpatient models drawing upon 3407 and 9028 observations respectively. Cost estimates are produced at country and regional level, with 95% confidence intervals. Inpatient costs across 30 countries are significantly associated with the type of hospital, ownership, as well as bed occupancy rate, average length of stay, and total number of inpatient admissions. Changes in outpatient costs are significantly associated with location, facility ownership and the level of care, as well as to the number of outpatient visits and visits per provider per day. These updated WHO-CHOICE service delivery unit costs are statistically robust and may be used by analysts as inputs for economic analysis. The models can predict country-specific unit costs at different capacity levels and in different settings.

Cost effectiveness of below-threshold waste disposal at DOE sites

International Nuclear Information System (INIS)

Smith, C.F.; Cohen, J.J.

1987-01-01

A minimal health and environmental risk, limitations on disposal capacity, and the relatively high costs of low level waste (LLW) disposal are basic driving forces that lead to consideration of less restrictive disposal of wastes with very low levels of radiological contamination. The term threshold limit describes radioactive wastes that have sufficiently low-levels of radiological content to be managed according to their nonradiological properties. Given the efforts described elsewhere to provide guidance on the definition of below threshold (BT) doses and concentration levels, the purpose of this study was to quantify the resultant quantities, costs and cost effectiveness of BT disposal. For purposes of consistency with the previous demonstrations of the application of the threshold concept, available data for waste streams at the Idaho National Engineering Laboratory (INEL) and the Savannah River Plant (SRP) sites were collected and analyzed with regard to volumes, radionuclide concentrations, and disposal costs. From this information, quantities of BT waste, potential cost savings and cost effectiveness values were estimated. 1 reference, 5 tables

MRS/IS facility co-located with a repository: preconceptual design and life-cycle cost estimates

International Nuclear Information System (INIS)

Smith, R.I.; Nesbitt, J.F.

1982-11-01

A program is described to examine the various alternatives for monitored retrievable storage (MRS) and interim storage (IS) of spent nuclear fuel, solidified high-level waste (HLW), and transuranic (TRU) waste until appropriate geologic repository/repositories are available. The objectives of this study are: (1) to develop a preconceptual design for an MRS/IS facility that would become the principal surface facility for a deep geologic repository when the repository is opened, (2) to examine various issues such as transportation of wastes, licensing of the facility, and environmental concerns associated with operation of such a facility, and (3) to estimate the life cycle costs of the facility when operated in response to a set of scenarios which define the quantities and types of waste requiring storage in specific time periods, which generally span the years from 1990 until 2016. The life cycle costs estimated in this study include: the capital expenditures for structures, casks and/or drywells, storage areas and pads, and transfer equipment; the cost of staff labor, supplies, and services; and the incremental cost of transporting the waste materials from the site of origin to the MRS/IS facility. Three scenarios are examined to develop estimates of life cycle costs of the MRS/IS facility. In the first scenario, HLW canisters are stored, starting in 1990, until the co-located repository is opened in the year 1998. Additional reprocessing plants and repositories are placed in service at various intervals. In the second scenario, spent fuel is stored, starting in 1990, because the reprocessing plants are delayed in starting operations by 10 years, but no HLW is stored because the repositories open on schedule. In the third scenario, HLW is stored, starting in 1990, because the repositories are delayed 10 years, but the reprocessing plants open on schedule

Towards a theory of product design specifications

DEFF Research Database (Denmark)

Hansen, Claus Thorp; Andreasen, Mogens Myrup

2004-01-01

, which express the customers¿ need and perception of value. In this paper we will scrutinize this assumption. We outline the roles and tasks of the product design specification in order to identify the requirements on a theory of product design specifications and we identify existing theory elements....... In the design methodology literature we find guidelines and methods to compile a product design specification. The contributions are based on the common underlying assumption that it is meaningful and the only feasible approach to interpret the result of a need analysis into a set of technical specifications...... to build such a theory of product design specifications upon....

Engaging design materials, formats and Framings in specific, situated co-designing

DEFF Research Database (Denmark)

Agger Eriksen, Mette

Engaging co-designers in specific situations of co- designing often also means engaging tangible working materials. However, it can be challenging, so rather than seeing it as applying design methods, the paper propose applying what I call a micro-material perspective. The practical concept captu......-design situations" clustered in three quite well- known types of co-design situations framed for; Exploring Current Use(r) Practices, Mapping Networks and Co-Designing (Possible) Futures.......Engaging co-designers in specific situations of co- designing often also means engaging tangible working materials. However, it can be challenging, so rather than seeing it as applying design methods, the paper propose applying what I call a micro-material perspective. The practical concept...... captures both paying attention to the physical design materials, the formats of their exploration and the framings of focus when understanding and planning such specific co-design situations. To exemplify applying the perspective, the paper describes and discusses six specific examples of "co...

Energy conserving site design case study, Burke Center, Virginia. Final report

Energy Technology Data Exchange (ETDEWEB)

1979-12-01

The pattern of energy consumption within a modern suburban community, Burke Center, is examined. A variety of actions that could be incorporated to reduce its future energy demands is proposed. Recommendations have been limited to those that are technically feasible today, are reasonably cost-effective, and that should generate little or no market resistance. Findings are that: of the total energy consumed by the Burke Center Community, 57% will go to off-site transportation needs; energy conserving site planning generally coincides with cost-effective site planning; water-to-air heat pumps proved to be the most efficient and cost-effective method available today in the study area for reducing heating and cooling costs in buildings; certain public services such as the collection of solid waste, mail pick-up and delivery, and other routine activities can be made more energy efficient; and the use of available water saving devices in residential and commercial buildings can reduce a community's total utility energy consumption by as much as 20%. (MCW)

Evaluation of site-specific factors influencing heavy metal contents in the topsoil of vegetated infiltration swales

International Nuclear Information System (INIS)

Horstmeyer, Nils; Huber, Maximilian; Drewes, Jörg E.; Helmreich, Brigitte

2016-01-01

Stormwater runoff of traffic areas is usually polluted by organic and inorganic substances and must be treated prior to discharge into groundwater. One widely used treatment method is infiltrating the runoff over the topsoil of vegetated swales. The aim of this study was to evaluate the factors influencing the heavy metal contents in such topsoil layers of vegetated infiltration swales near highways, roads, and parking lots. In total, 262 topsoil samples were taken from 35 sampling sites, which varied in age, traffic volume, road design, driving style, and site-specific conditions. In the evaluation of all soil samples, the median heavy metal values of cadmium, chromium, copper, lead, and zinc were yielding 0.36 (mean: 1.21) mg/kg DM, 37.0 (mean: 44.5) mg/kg DM, 28.0 (mean: 61.5) mg/kg DM, 27.0 (mean: 71.9) mg/kg DM, and 120 (mean: 257) mg/kg DM, respectively. The main purpose was to evaluate the site-specific data (i.e., surrounding land use characteristics, traffic area site data, and operational characteristics). In general, heavy metal contents increased with increasing traffic volumes. However, other factors also had a notable impact. Factors such as road design (e.g., curves, crossings, and roundabouts) and grade of congestion significantly influenced the heavy metal contents. High heavy metal contents were detected for stop-and-go areas, roundabouts, crossings, and sites with traffic lights, signs, and guardrails. Findings of this study can be used to identify highly polluted traffic areas and to verify or improve standards regarding the treatment of runoff from traffic areas. - Highlights: • Correlation of contents with traffic volume, road design, and stop-and-go traffic • Increased heavy metal contents at stop-and-go sites, roundabouts, and crossings • Different soil contents and behavior of cadmium, chromium, copper, lead, and zinc • Identification of factors influencing the variability of zinc in topsoil samples

Evaluation of site-specific factors influencing heavy metal contents in the topsoil of vegetated infiltration swales

Energy Technology Data Exchange (ETDEWEB)

Horstmeyer, Nils; Huber, Maximilian; Drewes, Jörg E.; Helmreich, Brigitte, E-mail: b.helmreich@tum.de

2016-08-01

Stormwater runoff of traffic areas is usually polluted by organic and inorganic substances and must be treated prior to discharge into groundwater. One widely used treatment method is infiltrating the runoff over the topsoil of vegetated swales. The aim of this study was to evaluate the factors influencing the heavy metal contents in such topsoil layers of vegetated infiltration swales near highways, roads, and parking lots. In total, 262 topsoil samples were taken from 35 sampling sites, which varied in age, traffic volume, road design, driving style, and site-specific conditions. In the evaluation of all soil samples, the median heavy metal values of cadmium, chromium, copper, lead, and zinc were yielding 0.36 (mean: 1.21) mg/kg DM, 37.0 (mean: 44.5) mg/kg DM, 28.0 (mean: 61.5) mg/kg DM, 27.0 (mean: 71.9) mg/kg DM, and 120 (mean: 257) mg/kg DM, respectively. The main purpose was to evaluate the site-specific data (i.e., surrounding land use characteristics, traffic area site data, and operational characteristics). In general, heavy metal contents increased with increasing traffic volumes. However, other factors also had a notable impact. Factors such as road design (e.g., curves, crossings, and roundabouts) and grade of congestion significantly influenced the heavy metal contents. High heavy metal contents were detected for stop-and-go areas, roundabouts, crossings, and sites with traffic lights, signs, and guardrails. Findings of this study can be used to identify highly polluted traffic areas and to verify or improve standards regarding the treatment of runoff from traffic areas. - Highlights: • Correlation of contents with traffic volume, road design, and stop-and-go traffic • Increased heavy metal contents at stop-and-go sites, roundabouts, and crossings • Different soil contents and behavior of cadmium, chromium, copper, lead, and zinc • Identification of factors influencing the variability of zinc in topsoil samples.

75 FR 64718 - Environmental Management Site-Specific Advisory Board, Nevada

Science.gov (United States)

2010-10-20

... Test Site including decontamination, closure, re-use and/or demolition. Purpose of the Soils Committee: The purpose of the Committee is to focus on issues related to soil contamination at the Nevada Test... Industrial Sites and Soils Committees of the Environmental Management Site-Specific Advisory Board (EM SSAB...

A grammar inference approach for predicting kinase specific phosphorylation sites.

Science.gov (United States)

Datta, Sutapa; Mukhopadhyay, Subhasis

2015-01-01

Kinase mediated phosphorylation site detection is the key mechanism of post translational mechanism that plays an important role in regulating various cellular processes and phenotypes. Many diseases, like cancer are related with the signaling defects which are associated with protein phosphorylation. Characterizing the protein kinases and their substrates enhances our ability to understand the mechanism of protein phosphorylation and extends our knowledge of signaling network; thereby helping us to treat such diseases. Experimental methods for predicting phosphorylation sites are labour intensive and expensive. Also, manifold increase of protein sequences in the databanks over the years necessitates the improvement of high speed and accurate computational methods for predicting phosphorylation sites in protein sequences. Till date, a number of computational methods have been proposed by various researchers in predicting phosphorylation sites, but there remains much scope of improvement. In this communication, we present a simple and novel method based on Grammatical Inference (GI) approach to automate the prediction of kinase specific phosphorylation sites. In this regard, we have used a popular GI algorithm Alergia to infer Deterministic Stochastic Finite State Automata (DSFA) which equally represents the regular grammar corresponding to the phosphorylation sites. Extensive experiments on several datasets generated by us reveal that, our inferred grammar successfully predicts phosphorylation sites in a kinase specific manner. It performs significantly better when compared with the other existing phosphorylation site prediction methods. We have also compared our inferred DSFA with two other GI inference algorithms. The DSFA generated by our method performs superior which indicates that our method is robust and has a potential for predicting the phosphorylation sites in a kinase specific manner.

A Grammar Inference Approach for Predicting Kinase Specific Phosphorylation Sites

Science.gov (United States)

Datta, Sutapa; Mukhopadhyay, Subhasis

2015-01-01

Kinase mediated phosphorylation site detection is the key mechanism of post translational mechanism that plays an important role in regulating various cellular processes and phenotypes. Many diseases, like cancer are related with the signaling defects which are associated with protein phosphorylation. Characterizing the protein kinases and their substrates enhances our ability to understand the mechanism of protein phosphorylation and extends our knowledge of signaling network; thereby helping us to treat such diseases. Experimental methods for predicting phosphorylation sites are labour intensive and expensive. Also, manifold increase of protein sequences in the databanks over the years necessitates the improvement of high speed and accurate computational methods for predicting phosphorylation sites in protein sequences. Till date, a number of computational methods have been proposed by various researchers in predicting phosphorylation sites, but there remains much scope of improvement. In this communication, we present a simple and novel method based on Grammatical Inference (GI) approach to automate the prediction of kinase specific phosphorylation sites. In this regard, we have used a popular GI algorithm Alergia to infer Deterministic Stochastic Finite State Automata (DSFA) which equally represents the regular grammar corresponding to the phosphorylation sites. Extensive experiments on several datasets generated by us reveal that, our inferred grammar successfully predicts phosphorylation sites in a kinase specific manner. It performs significantly better when compared with the other existing phosphorylation site prediction methods. We have also compared our inferred DSFA with two other GI inference algorithms. The DSFA generated by our method performs superior which indicates that our method is robust and has a potential for predicting the phosphorylation sites in a kinase specific manner. PMID:25886273

Effect of rotor configuration on guyed tower and foundation designs and estimated costs for intermediate site horizontal axis wind turbines

Science.gov (United States)

Frederick, G. R.; Winemiller, J. R.; Savino, J. M.

1982-01-01

Three designs of a guyed cylindrical tower and its foundation for an intermediate size horizontal axis wind turbine generator are discussed. The primary difference in the three designs is the configuration of the rotor. Two configurations are two-blade rotors with teetering hubs - one with full span pitchable blades, the other with fixed pitch blades. The third configuration is a three-bladed rotor with a rigid hub and fixed pitch blades. In all configurations the diameter of the rotor is 38 meters and the axis of rotation is 30.4 meters above grade, and the power output is 200 kW and 400 kW. For each configuration the design is based upon for the most severe loading condition either operating wind or hurricane conditions. The diameter of the tower is selected to be 1.5 meters (since it was determined that this would provide sufficient space for access ladders within the tower) with guy rods attached at 10.7 meters above grade. Completing a design requires selecting the required thicknesses of the various cylindrical segments, the number and diameter of the guy rods, the number and size of soil anchors, and the size of the central foundation. The lower natural frequencies of vibration are determined for each design to ensure that operation near resonance does not occur. Finally, a cost estimate is prepared for each design. A preliminary design and cost estimate of a cantilever tower (cylindrical and not guyed) and its foundation is also presented for each of the three configurations.

Comparison and Evaluation of Large-Scale and On-Site Recycling Systems for Food Waste via Life Cycle Cost Analysis

Directory of Open Access Journals (Sweden)

Kyoung Hee Lee

2017-11-01

Full Text Available The purpose of this study was to evaluate the cost-benefit of on-site food waste recycling system using Life-Cycle Cost analysis, and to compare with large-scale treatment system. For accurate evaluation, the cost-benefit analysis was conducted with respect to local governments and residents, and qualitative environmental improvement effects were quantified. As for the local governments, analysis results showed that, when large-scale treatment system was replaced with on-site recycling system, there was significant cost reduction from the initial stage depending on reduction of investment, maintenance, and food wastewater treatment costs. As for the residents, it was found that the cost incurred from using the on-site recycling system was larger than the cost of using large-scale treatment system due to the cost of producing and installing the on-site treatment facilities at the initial stage. However, analysis showed that with continuous benefits such as greenhouse gas emission reduction, compost utilization, and food wastewater reduction, cost reduction would be obtained after 6 years of operating the on-site recycling system. Therefore, it was recommended for local governments and residents to consider introducing an on-site food waste recycling system if they are to replace an old treatment system or need to establish a new one.

Temporally-controlled site-specific recombination in zebrafish.

Directory of Open Access Journals (Sweden)

Stefan Hans

Full Text Available Conventional use of the site-specific recombinase Cre is a powerful technology in mouse, but almost absent in other vertebrate model organisms. In zebrafish, Cre-mediated recombination efficiency was previously very low. Here we show that using transposon-mediated transgenesis, Cre is in fact highly efficient in this organism. Furthermore, temporal control of recombination can be achieved by using the ligand-inducible CreER(T2. Site-specific recombination only occurs upon administration of the drug tamoxifen (TAM or its active metabolite, 4-hydroxy-tamoxifen (4-OHT. Cre-mediated recombination is detectable already 4 or 2 hours after administration of TAM or 4-OHT, demonstrating fast recombination kinetics. In addition, low doses of TAM allow mosaic labeling of single cells. Combined, our results show that conditional Cre/lox will be a valuable tool for both, embryonic and adult zebrafish studies. Furthermore, single copy insertion transgenesis of Cre/lox constructs suggest a strategy suitable also for other organisms.

Novel Prostate Specific Antigen plastic antibody designed with charged binding sites for an improved protein binding and its application in a biosensor of potentiometric transduction

International Nuclear Information System (INIS)

Rebelo, Tânia S.C.R.; Santos, C.; Costa-Rodrigues, J.; Fernandes, M.H.; Noronha, João P.; Sales, M. Goreti F.

2014-01-01

Graphical abstract: EF13-201, Novel Prostate Specific Antigen plastic antibody designed with charged binding sites for an improved protein binding and its application in a biosensor of potentiometric transduction. - Abstract: This work shows that the synthesis of protein plastic antibodies tailored with selected charged monomers around the binding site enhances protein binding. These charged receptor sites are placed over a neutral polymeric matrix, thus inducing a suitable orientation the protein reception to its site. This is confirmed by preparing control materials with neutral monomers and also with non-imprinted template. This concept has been applied here to Prostate Specific Antigen (PSA), the protein of choice for screening prostate cancer throughout the population, with serum levels >10 ng/mL pointing out a high probability of associated cancer. Protein Imprinted Materials with charged binding sites (C/PIM) have been produced by surface imprinting over graphene layers to which the protein was first covalently attached. Vinylbenzyl(trimethylammonium chloride) and vinyl benzoate were introduced as charged monomers labelling the binding site and were allowed to self-organize around the protein. The subsequent polymerization was made by radical polymerization of vinylbenzene. Neutral PIM (N/PIM) prepared without oriented charges and non imprinted materials (NIM) obtained without template were used as controls. These materials were used to develop simple and inexpensive potentiometric sensor for PSA. They were included as ionophores in plasticized PVC membranes, and tested over electrodes of solid or liquid conductive contacts, made of conductive carbon over a syringe or of inner reference solution over micropipette tips. The electrodes with charged monomers showed a more stable and sensitive response, with an average slope of -44.2 mV/decade and a detection limit of 5.8 × 10 −11 mol/L (2 ng/mL). The corresponding non-imprinted sensors showed lower

Shifting the Paradigm for Long Term Monitoring at Legacy Sites to Improve Performance while Reducing Costs - 13422

International Nuclear Information System (INIS)

Eddy-Dilek, Carol A; Looney, Brian B.; Gaughan, Thomas; Kmetz, Thomas; Seaman, John

2013-01-01

A major issue facing many government and private industry sites that were previously contaminated with radioactive and chemical wastes is that often the sites cannot be cleaned up enough to permit unrestricted human access. These sites will require long-term management, in some cases indefinitely, leaving site owners with the challenge of protecting human health and environmental quality in a cost effective manner. Long-term monitoring of groundwater contamination is one of the largest projected costs in the life cycle of environmental management at the Savannah River Site (SRS), the larger DOE complex, and many large federal and private sites. Currently, most monitoring strategies are focused on laboratory measurements of contaminants measured in groundwater samples collected from wells. This approach is expensive, and provides limited and lagging information about the effectiveness of cleanup activities and the behavior of the residual contamination. Over the last twenty years, DOE and other federal agencies have made significant investments in the development of various types of sensors and strategies that would allow for remote analysis of contaminants in groundwater, but these approaches do not promise significant reductions in risk or cost. Scientists at SRS have developed a new paradigm to simultaneously improve the performance of long term monitoring systems while lowering the overall cost of monitoring. This alternative approach incorporates traditional point measurements of contaminant concentration with measurements of controlling variables including boundary conditions, master variables, and traditional plume/contaminant variables. Boundary conditions are the overall driving forces that control plume movement and therefore provide leading indication to changes in plume stability. These variables include metrics associated with meteorology, hydrology, hydrogeology, and land use. Master variables are the key variables that control the chemistry of the

Shifting the Paradigm for Long Term Monitoring at Legacy Sites to Improve Performance while Reducing Costs - 13422

Energy Technology Data Exchange (ETDEWEB)

Eddy-Dilek, Carol A; Looney, Brian B. [Savannah River National Laboratory (United States); Gaughan, Thomas; Kmetz, Thomas [Savannah River Nuclear Solutions, LLC (United States); Seaman, John [Savannah River Ecology Laboratory (United States)

2013-07-01

A major issue facing many government and private industry sites that were previously contaminated with radioactive and chemical wastes is that often the sites cannot be cleaned up enough to permit unrestricted human access. These sites will require long-term management, in some cases indefinitely, leaving site owners with the challenge of protecting human health and environmental quality in a cost effective manner. Long-term monitoring of groundwater contamination is one of the largest projected costs in the life cycle of environmental management at the Savannah River Site (SRS), the larger DOE complex, and many large federal and private sites. Currently, most monitoring strategies are focused on laboratory measurements of contaminants measured in groundwater samples collected from wells. This approach is expensive, and provides limited and lagging information about the effectiveness of cleanup activities and the behavior of the residual contamination. Over the last twenty years, DOE and other federal agencies have made significant investments in the development of various types of sensors and strategies that would allow for remote analysis of contaminants in groundwater, but these approaches do not promise significant reductions in risk or cost. Scientists at SRS have developed a new paradigm to simultaneously improve the performance of long term monitoring systems while lowering the overall cost of monitoring. This alternative approach incorporates traditional point measurements of contaminant concentration with measurements of controlling variables including boundary conditions, master variables, and traditional plume/contaminant variables. Boundary conditions are the overall driving forces that control plume movement and therefore provide leading indication to changes in plume stability. These variables include metrics associated with meteorology, hydrology, hydrogeology, and land use. Master variables are the key variables that control the chemistry of the

Cost vs. safety: A novel design for t

Directory of Open Access Journals (Sweden)

Komali Kantamaneni

2017-08-01

Full Text Available Tornadoes are dangerous and destructive weather phenomena. The strongest category of tornadoes on the enhanced Fujita and TORRO scales is responsible for 75% of property destruction and deaths across the globe. These issues highlight the need for new design practices aimed at producing tornado proof homes in particular 3D CAD models in tornado prone zones at current climatic scenarios. Previous studies were entirely based on traditional slants and failed to offer a reliable tornado proof home, other than small rooms and trailers, while, none of the literature concentrated on multiple factors (cost, safety and high-wind proof. Therefore, a knowledge gap exists. In order to address the current research gap, this study attempts to develop an innovative 3D CAD model for tornado resistant homes by incorporating 2 PA (Two Path Analysis. Consequently, this study provides a new design using a 3D-CAD model for a tornado resistant home as in Path One and cost and safety scenarios in Path Two. However, this new design utilizes missile steel and shield technology. Preliminary results showed that, while this new design is safer and more technically sophisticated, it involves an increase of 25–30% in construction costs. However, this increased expense is low in comparison with rebuilding costs.

Early Site Permit Demonstration Program: Recommendations for communication activities and public participation in the Early Site Permit Demonstration Program

International Nuclear Information System (INIS)

1993-01-01

On October 24, 1992, President Bush signed into law the National Energy Policy Act of 1992. The bill is a sweeping, comprehensive overhaul of the Nation's energy laws, the first in more than a decade. Among other provisions, the National Energy Policy Act reforms the licensing process for new nuclear power plants by adopting a new approach developed by the US Nuclear Regulatory Commission (NRC) in 1989, and upheld in court in 1992. The NRC 10 CFR Part 52 rule is a three-step process that guarantees public participation at each step. The steps are: early site permit approval; standard design certifications; and, combined construction/operating licenses for nuclear power reactors. Licensing reform increases an organization's ability to respond to future baseload electricity generation needs with less financial risk for ratepayers and the organization. Costly delays can be avoided because design, safety and siting issues will be resolved before a company starts to build a plant. Specifically, early site permit approval allows for site suitability and acceptability issues to be addressed prior to an organization's commitment to build a plant. Responsibility for site-specific activities, including communications and public participation, rests with those organizations selected to try out early site approval. This plan has been prepared to assist those companies (referred to as sponsoring organizations) in planning their communications and public involvement programs. It provides research findings, information and recommendations to be used by organizations as a resource and starting point in developing their own plans

Cost Optimal Design of a Single-Phase Dry Power Transformer

Directory of Open Access Journals (Sweden)

Raju Basak

2015-08-01

Full Text Available The Dry type transformers are preferred to their oil-immersed counterparts for various reasons, particularly because their operation is hazardless. The application of dry transformers was limited to small ratings in the earlier days. But now these are being used for considerably higher ratings.  Therefore, their cost-optimal design has gained importance. This paper deals with the design procedure for achieving cost optimal design of a dry type single-phase power transformer of small rating, subject to usual design constraints on efficiency and voltage regulation. The selling cost for the transformer has been taken as the objective function. Only two key variables have been chosen, the turns/volt and the height: width ratio of window, which affects the cost function to high degrees. Other variables have been chosen on the basis of designers’ experience. Copper has been used as conductor material and CRGOS as core material to achieve higher efficiency, lower running cost and compact design. The electrical and magnetic loadings have been kept at their maximum values without violating the design constraints. The optimal solution has been obtained by the method of exhaustive search using nested loops.

Selective pressures to maintain attachment site specificity of integrative and conjugative elements.

Directory of Open Access Journals (Sweden)

Kayla L Menard

Full Text Available Integrative and conjugative elements (ICEs are widespread mobile genetic elements that are usually found integrated in bacterial chromosomes. They are important agents of evolution and contribute to the acquisition of new traits, including antibiotic resistances. ICEs can excise from the chromosome and transfer to recipients by conjugation. Many ICEs are site-specific in that they integrate preferentially into a primary attachment site in the bacterial genome. Site-specific ICEs can also integrate into secondary locations, particularly if the primary site is absent. However, little is known about the consequences of integration of ICEs into alternative attachment sites or what drives the apparent maintenance and prevalence of the many ICEs that use a single attachment site. Using ICEBs1, a site-specific ICE from Bacillus subtilis that integrates into a tRNA gene, we found that integration into secondary sites was detrimental to both ICEBs1 and the host cell. Excision of ICEBs1 from secondary sites was impaired either partially or completely, limiting the spread of ICEBs1. Furthermore, induction of ICEBs1 gene expression caused a substantial drop in proliferation and cell viability within three hours. This drop was dependent on rolling circle replication of ICEBs1 that was unable to excise from the chromosome. Together, these detrimental effects provide selective pressure against the survival and dissemination of ICEs that have integrated into alternative sites and may explain the maintenance of site-specific integration for many ICEs.

Customer Focused Product Design Using Integrated Model of Target Costing, Quality Function Deployment and Value Engineering

Directory of Open Access Journals (Sweden)

Hossein Rezaei Dolatabadi

2013-01-01

Full Text Available Target costing by integrating customer requirements, technical attributes and cost information into the product design phase and eliminating the non-value added functions, plays a vital role in different phases of the product life cycle. Quality Function Deployment (QFD and Value Engineering (VE are two techniques which can be used for applying target costing, successfully. The purpose of this paper is to propose an integrated model of target costing, QFD and VE to explore the role of target costing in managing product costs while promoting quality specifications meeting customers’ needs. F indings indicate that the integration of target costing, QFD and VE is an essential technique in managing the costs of production process. Findings also imply that integration of the three techniques provides a competitive cost advantage to companies.

Cost Control Strategies for Zero Energy Buildings: High-Performance Design and Construction on a Budget (Brochure)

Energy Technology Data Exchange (ETDEWEB)

2014-09-01

There is mounting evidence that zero energy can, in many cases, be achieved within typical construction budgets. To ensure that the momentum behind zero energy buildings and other low-energy buildings will continue to grow, this guide assembles recommendations for replicating specific successes of early adopters who have met their energy goals while controlling costs. Contents include: discussion of recommended cost control strategies, which are grouped by project phase (acquisition and delivery, design, and construction) and accompanied by industry examples; recommendations for balancing key decision-making factors; and quick reference tables that can help teams apply strategies to specific projects.

A Systematic Procedure for the Generation of Cost-Minimized Designs

DEFF Research Database (Denmark)

Becker, Peter W.; Jarkler, Bjorn

1972-01-01

We present a procedure for the generation of cost-minimized designs of circuits and systems. Suppose a designer has decided upon the topology of his product. Also suppose he knows the cost and quality of the different grades of the N components required to implement the product. The designer...... then faces the following problem: How should he proceed to find the combination of grades that will give him the desired manufacturing yield at minimum product cost? We discuss the problem and suggest a policy by which the designer, with a reasonable computational effort, can find a set of ``good...

GTHTR300 cost reduction through design upgrade and cogeneration

Energy Technology Data Exchange (ETDEWEB)

Yan, Xing L., E-mail: yan.xing@jaea.go.jp; Sato, Hiroyuki; Kamiji, Yu; Imai, Yoshiyuki; Terada, Atsuhiko; Tachibana, Yukio; Kunitomi, Kazuhiko

2016-09-15

Japan Atomic Energy Agency began design and development of the Gas Turbine High Temperature Reactor of 300MWe nominal output (GTHTR300) in 2001. The reactor baseline design completed three years later was based on 850 °C core outlet temperature and a direct cycle gas turbine balance of plant. It attained 45.6% net power generation efficiency and 3.5 US¢/kW h cost of electricity. The cost was estimated 20% lower than LWR. The latest design upgrade has incorporated several major technological advances made in the past ten years to both reactor and balance of plant. As described in this paper, these advances have enabled raising the design basis reactor core outlet temperature to 950 °C and increasing power generating efficiency by nearly 5% point. Further implementation of seawater desalination cogeneration is made through employing a newly-proposed multi-stage flash process. Through efficient waste heat recovery of the reactor gas turbine power conversion cycle, a large cost credit is obtained against the conventionally produced water prices. Together, the design upgrade and the cogeneration are shown to reduce the GTHTR300 cost of electricity to under 2.7 US¢/kW h.

GTHTR300 cost reduction through design upgrade and cogeneration

International Nuclear Information System (INIS)

Yan, Xing L.; Sato, Hiroyuki; Kamiji, Yu; Imai, Yoshiyuki; Terada, Atsuhiko; Tachibana, Yukio; Kunitomi, Kazuhiko

2014-01-01

Japan Atomic Energy Agency began design and development of the Gas Turbine High Temperature Reactor of 300MWe nominal output (GTHTR300) in 2001. The reactor baseline design completed three years later was based on 850°C core outlet temperature and a direct cycle gas turbine balance of plant. It attained 45.6% net power generation efficiency and 3.5US¢/KWh cost of electricity. The cost was estimated 20% lower than LWR. The latest design upgrade has incorporated several major technological advances made in the past ten years to both reactor and balance of plant. As described in this paper, these advances have enabled raising the design basis reactor core outlet temperature to 950°C and increasing power generating efficiency by nearly 5% point. Further implementation of seawater desalination cogeneration is made through employing a newly-proposed multi-stage flash process. Through efficient waste heat recovery of the reactor gas turbine power conversion cycle, a large cost credit is obtained against the conventionally produced water prices. Together, the design upgrade and the cogeneration are shown to reduce the GTHTR300 cost of electricity to under 2.7 US¢/KWh. (author)

Cost Optimal System Identification Experiment Design

DEFF Research Database (Denmark)

Kirkegaard, Poul Henning

A structural system identification experiment design method is formulated in the light of decision theory, structural reliability theory and optimization theory. The experiment design is based on a preposterior analysis, well-known from the classical decision theory. I.e. the decisions concerning...... reflecting the cost of the experiment and the value of obtained additional information. An example concerning design of an experiment for parametric identification of a single degree of freedom structural system shows the applicability of the experiment design method....... the experiment design are not based on obtained experimental data. Instead the decisions are based on the expected experimental data assumed to be obtained from the measurements, estimated based on prior information and engineering judgement. The design method provides a system identification experiment design...

A design method for an intuitive web site

Energy Technology Data Exchange (ETDEWEB)

Quinniey, M.L.; Diegert, K.V.; Baca, B.G.; Forsythe, J.C.; Grose, E.

1999-11-03

The paper describes a methodology for designing a web site for human factor engineers that is applicable for designing a web site for a group of people. Many web pages on the World Wide Web are not organized in a format that allows a user to efficiently find information. Often the information and hypertext links on web pages are not organized into intuitive groups. Intuition implies that a person is able to use their knowledge of a paradigm to solve a problem. Intuitive groups are categories that allow web page users to find information by using their intuition or mental models of categories. In order to improve the human factors engineers efficiency for finding information on the World Wide Web, research was performed to develop a web site that serves as a tool for finding information effectively. The paper describes a methodology for designing a web site for a group of people who perform similar task in an organization.

Site specific modification of the human plasma proteome by methylglyoxal

International Nuclear Information System (INIS)

Kimzey, Michael J.; Kinsky, Owen R.; Yassine, Hussein N.; Tsaprailis, George; Stump, Craig S.; Monks, Terrence J.; Lau, Serrine S.

2015-01-01

Increasing evidence identifies dicarbonyl stress from reactive glucose metabolites, such as methylglyoxal (MG), as a major pathogenic link between hyperglycemia and complications of diabetes. MG covalently modifies arginine residues, yet the site specificity of this modification has not been thoroughly investigated. Sites of MG adduction in the plasma proteome were identified using LC–MS/MS analysis in vitro following incubation of plasma proteins with MG. Treatment of plasma proteins with MG yielded 14 putative MG hotspots from five plasma proteins (albumin [nine hotspots], serotransferrin, haptoglobin [2 hotspots], hemopexin, and Ig lambda-2 chain C regions). The search results revealed two versions of MG-arginine modification, dihydroxyimidazolidine (R + 72) and hydroimidazolone (R + 54) adducts. One of the sites identified was R257 in human serum albumin, which is a critical residue located in drug binding site I. This site was validated as a target for MG modification by a fluorescent probe displacement assay, which revealed significant drug dissociation at 300 μM MG from a prodan–HSA complex (75 μM). Moreover, twelve human plasma samples (six male, six female, with two type 2 diabetic subjects from both genders) were analyzed using multiple reaction monitoring (MRM) tandem mass spectrometry and revealed the presence of the MG-modified albumin R257 peptide. These data provide insights into the nature of the site-specificity of MG modification of arginine, which may be useful for therapeutic treatments that aim to prevent MG-mediated adverse responses in patients. - Highlights: • Methylglyoxal (MG) selectively modifies arginine sites in human plasma proteome. • Dihydroxyimidazolidine and hydroimidazolone adducts on serum albumin identified • MG modification on albumin R257 associated with loss of drug site I binding capacity • MRM-tandem mass spectrometry enables sensitive detection of albumin MG-R257. • Site-specific MG modification may