WorldWideScience

Sample records for site-directed research development

  1. Nevada Test Site-Directed Research, Development, and Demonstration

    International Nuclear Information System (INIS)

    Will Lewis, Compiler

    2006-01-01

    The Nevada Test Site-Directed Research, Development, and Demonstration (SDRD) program completed a very successful year of research and development activities in FY 2005. Fifty new projects were selected for funding this year, and five FY 2004 projects were brought to conclusion. The total funds expended by the SDRD program were $5.4 million, for an average per project cost of just under $100,000. Two external audits of SDRD accounting practices were conducted in FY 2005. Both audits found the program's accounting practices consistent with the requirements of DOE Order 413.2A, and one included the observation that the NTS contractor ''did an exceptional job in planning and executing year-start activities.'' Highlights for the year included: the filing of 18 invention disclosures for intellectual property generated by FY 2005 projects; programmatic adoption of 17 FY 2004 SDRD-developed technologies; participation in the tri-lab Laboratory Directed Research and Development (LDRD) and SDRD program review that was broadly attended by NTS, NNSA, LDRD, and U.S. Department of Homeland Security representatives; peer reviews of all FY 2005 projects; and the successful completion of 55 R and D projects, as presented in this report

  2. FY 2016 Site-Directed Research & Development Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Bender, Howard [National Security Technologies, LLC. (NSTec), Mercury, NV (United States)

    2017-04-01

    As the Nevada National Security Site (NNSS) continues to evolve and transition its mission to a broader scope, significant challenges lie ahead that present unique opportunities for our research and development (R&D) enterprise. At the juncture, we are poised to create a different future investment strategy. Our decisions at the beginning of a new tri-decade span must be guided as expertly as possible given the greater complexity and multifaceted nature of our work.

  3. Site-Directed Research and Development FY 2012 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    ,

    2013-04-01

    The reports included in this report are for project activities that occurred from October 2011 through September 2012. These reports describe in detail the discoveries, achievements, and challenges encountered by our talented and enthusiastic principal investigators (PIs). Many of the reports describe R&D efforts that were “successful” in their pursuits and resulted in a positive outcome or technology realization. As we’ve stated before, and continue to stress, in some cases the result is a “negative” finding, for instance a technology is currently impractical or out of reach. This can often be viewed erroneously as a “failure,” but is actually a valid outcome in the pursuit of high-risk research, which often leads to unforeseen new paths of discovery. Either result advances our knowledge and increases our ability to identify solutions and/or likewise avoid costly paths not appropriate for the challenges presented. The SDRD program continues to provide an unfettered mechanism for innovation and development that returns multifold to the NNSS mission. Overall the program is a strong R&D innovation engine, benefited by an enhanced mission, committed resources, and sound competitiveness to yield maximum benefit. The 23 projects described exemplify the creativity and ability of a diverse scientific and engineering talent base. The efforts also showcase an impressive capability and resource that can be brought to find solutions to a broad array of technology needs and applications relevant to the NNSS mission and national security.

  4. Site-Directed Research and Development FY 2014 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Bender, H. A. [Nevada Test Site/National Security Technologies, LLC (United States)

    2015-04-22

    The reports contained herein are for project activities that occurred from October 2013 through September 2014. Project life cycle is indicated under the title as well as the original proposal number (in the following format: site abbreviation--ID #--originating fiscal year; e.g., STL-03-14). Each of the reports describes in detail the discoveries, achievements, and challenges encountered by our principal investigators. As SDRD, by definition, invests in “high-risk” and hopefully “high-payoff” research, the element of uncertainty is inherent. While many of our efforts are “successful” and result in positive outcomes or technology utilization, some fall short of expectations, but cannot be construed as “failure” in the negative sense. The latter is a natural and valid part of the process of advanced research and often leads to unforeseen new pathways to future discovery. Regardless, either result advances our knowledge base and increases our ability to identify solutions and/or avoid costly and unwarranted paths for future challenges. In summary, the SDRD program continues to provide an unfettered mechanism for innovation that returns multifold to our customers, to national security, and to the general public. The program is a vibrant R&D innovation engine, benefited by its discretionary pedigree, enhanced mission spectrum, committed resources, and sound competitiveness to yield maximum taxpayer benefit. The 25 projects described exemplify the creativity and ability of a diverse scientific and engineering talent base. The efforts also showcase an impressive capability and resource that can be brought to find solutions to a broad array of technology needs and applications relevant to the NNSS mission and national security. Further SDRD performance metrics can be found in the appendix at the end of this report.

  5. Nevada Test Site-Directed Research and Development: FY 2006 Report

    International Nuclear Information System (INIS)

    Wil Lewis, editor

    2007-01-01

    The Nevada Test Site Directed Research and Development (SDRD) program completed its fifth successful year of research and development activities in FY 2006. Forty new projects were selected for funding this year, and ten FY 2005 projects were brought to conclusion. The total funds expended by the SDRD program were $6 million, for an average per-project cost of $120 thousand. Beginning in May, 2006 programmatic burden rates were applied to SDRD project costs. An external audit conducted in September 2006 verified that appropriate accounting practices were applied to the SDRD program. Highlights for the year included: the filing of 27 invention disclosures for intellectual property generated by FY 2006 projects; programmatic adoption of four FY 2005 SDRD-developed technologies; participation in the tri-Lab Laboratory Directed Research and Development (LDRD) and SDRD program review that was broadly attended by NTS, NNSA, LDRD, and U.S. Department of Homeland Security representatives; peer reviews of all FY 2006 projects; and the successful completion of 50 R and D projects, as presented in this report

  6. Nevada Test Site-Directed Research, Development, and Demonstration. FY2005 report

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Will [comp.

    2006-09-01

    The Nevada Test Site-Directed Research, Development, and Demonstration (SDRD) program completed a very successful year of research and development activities in FY 2005. Fifty new projects were selected for funding this year, and five FY 2004 projects were brought to conclusion. The total funds expended by the SDRD program were $5.4 million, for an average per project cost of just under $100,000. Two external audits of SDRD accounting practices were conducted in FY 2005. Both audits found the program's accounting practices consistent with the requirements of DOE Order 413.2A, and one included the observation that the NTS contractor ''did an exceptional job in planning and executing year-start activities.'' Highlights for the year included: the filing of 18 invention disclosures for intellectual property generated by FY 2005 projects; programmatic adoption of 17 FY 2004 SDRD-developed technologies; participation in the tri-lab Laboratory Directed Research and Development (LDRD) and SDRD program review that was broadly attended by NTS, NNSA, LDRD, and U.S. Department of Homeland Security representatives; peer reviews of all FY 2005 projects; and the successful completion of 55 R&D projects, as presented in this report.

  7. Nevada National Security Site: Site-Directed Research and Development (SDRD) Fiscal Year 2015 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Bender, Howard A. [National Security Technologies, LLC. (NSTec), Mercury, NV (United States). Site-Directed Research and Development Program

    2016-04-01

    This report presents results of multiple research projects, new and ongoing, funded under the Site-Directed Research and Development Program for the Nevada National Security Site during federal fiscal year 2015. The Site's legacy capabilities in remote sensing combined with new paradigms for emergency response and consequence management help drive the need to develop advanced aerial sensor platforms. Likewise, dynamic materials science is a critical area of scientific research for which basic physics issues are still unresolved. New methods of characterizing materials in extreme states are vitally needed, and these efforts are paving the way with new knowledge. Projects selected in FY 2015 for the Exploratory Research portfolio exhibit a strong balance of NNSS mission relevance. Geoscience, seismology, and techniques for detecting underground nuclear events are still essential focus areas. Many of the project reports in the second major section of this annual report are ongoing continuations in multi-year lifecycles. Diagnostic techniques for stockpile and nuclear security science figured prominently as well, with a few key efforts coming to fruition, such as phase transition detection. In other areas, modeling efforts toward better understanding plasma focus physics has also started to pay dividends for major program needs.

  8. Nevada Test Site-Directed Research and Development FY 2010 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Howard Bender, comp.

    2011-04-04

    This annual report of the Site-Directed Research and Development (SDRD) program represents the highly significant R&D accomplishments conducted during fiscal year 2010. This year was noteworthy historically, as the Nevada Test Site was renamed to the Nevada National Security Site (NNSS). This change not only recognizes how the site's mission has evolved, but also heralds a future of new challenges and opportunities for the NNSS. In many ways, since its inception in 2002, the SDRD program has helped shape that evolving mission. As we approach 2012, SDRD will also mark a milestone, having completed its first full decade of innovative R&D in support of the site and national security. The program continues to fund advanced science and technology development across traditional Department of Energy (DOE) nuclear security areas such as stockpile stewardship and non-proliferation while also supporting Department of Homeland Security (DHS) needs, and specialized work for government agencies like the Department of Defense (DoD) and others. The NNSS will also contribute technologies in the areas of treaty verification and monitoring, two areas of increasing importance to national security. Keyed to the NNSS's broadened scope, the SDRD program will continue to anticipate and advance R&D projects that will help the NNSS meet forthcoming challenges.

  9. Nevada Natonal Security Site-Directed Research and Development FY 2010 Annual Report

    International Nuclear Information System (INIS)

    Bender, Howard

    2011-01-01

    This annual report of the Site-Directed Research and Development (SDRD) program represents the highly significant R and D accomplishments conducted during fiscal year 2010. This year was noteworthy historically, as the Nevada Test Site was renamed to the Nevada National Security Site (NNSS). This change not only recognizes how the site's mission has evolved, but also heralds a future of new challenges and opportunities for the NNSS. In many ways, since its inception in 2002, the SDRD program has helped shape that evolving mission. As we approach 2012, SDRD will also mark a milestone, having completed its first full decade of innovative R and D in support of the site and national security. The program continues to fund advanced science and technology development across traditional Department of Energy (DOE) nuclear security areas such as stockpile stewardship and non-proliferation while also supporting Department of Homeland Security (DHS) needs, and specialized work for government agencies like the Department of Defense (DoD) and others. The NNSS will also contribute technologies in the areas of treaty verification and monitoring, two areas of increasing importance to national security. Keyed to the NNSS's broadened scope, the SDRD program will continue to anticipate and advance R and D projects that will help the NNSS meet forthcoming challenges.

  10. Nevada National Security Site. Site-Directed Research and Development FY 2011 Annual Report

    International Nuclear Information System (INIS)

    Bender, Howard

    2012-01-01

    This fiscal year 2011 annual report of the Site-Directed Research and Development program, the 10th anniversary edition, recognizes a full decade of innovative R and D accomplishments in support of the Nevada National Security Site (NNSS). Last year the NNSS itself was renamed to reflect a diversifying mission, and our R and D program has contributed significantly to shape emerging missions that will continue to evolve. New initiatives in stockpile stewardship science, nonproliferation, and treaty verification and monitoring have had substantial successes in FY 2011, and many more accomplishments are expected. SDRD is the cornerstone on which many of these initiatives rest. Historically supporting our main focus areas, SDRD is also building a solid foundation for new, and non-traditional, emerging national security missions. The program continues its charter to advance science and technology for a broad base of agencies including the U.S. Department of Energy (DOE), U.S. Department of Defense (DoD), U.S. Department of Homeland Security (DHS), and many others.

  11. Nevada National Security Site-Directed Research and Development FY 2011 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Howard Bender, comp.

    2012-04-25

    This fiscal year 2011 annual report of the Site-Directed Research and Development program, the 10th anniversary edition, recognizes a full decade of innovative R&D accomplishments in support of the Nevada National Security Site (NNSS). Last year the NNSS itself was renamed to reflect a diversifying mission, and our R&D program has contributed significantly to shape emerging missions that will continue to evolve. New initiatives in stockpile stewardship science, nonproliferation, and treaty verification and monitoring have had substantial successes in FY 2011, and many more accomplishments are expected. SDRD is the cornerstone on which many of these initiatives rest. Historically supporting our main focus areas, SDRD is also building a solid foundation for new, and non-traditional, emerging national security missions. The program continues its charter to advance science and technology for a broad base of agencies including the U.S. Department of Energy (DOE), U.S. Department of Defense (DoD), U.S. Department of Homeland Security (DHS), and many others.

  12. Nevada Test Site-Directed Research and Development, FY 2007 Report

    International Nuclear Information System (INIS)

    Wil Lewis, editor

    2008-01-01

    The Nevada Test Site-Directed Research and Development (SDRD) program completed a very successful year of research and development activities in FY 2007. Twenty-nine new projects were selected for funding this year, and eight projects started in FY 2006 were brought to conclusion. The total funds expended by the SDRD program were $5.67 million, for an average per-project cost of $153 thousand. An external audit conducted in September 2007 verified that appropriate accounting practices were applied to the SDRD program. Highlights for the year included: programmatic adoption of 8 SDRD-developed technologies; the filing of 9 invention disclosures for innovation evolving from SDRD projects; participation in the tri-Lab Laboratory Directed Research and Development (LDRD) and SDRD Symposium that was broadly attended by Nevada Test Site (NTS), National Nuclear Security Administration (NNSA), LDRD, U.S. Department of Homeland Security (DHS), and U.S. Department of Defense (DoD) representatives; peer reviews of all FY 2007 projects; and the successful completion of 37 R and D projects, as presented in this report. In response to a company-wide call, authors throughout the NTS complex submitted 182 proposals for FY 2007 SDRD projects. The SDRD program has seen a dramatic increase in the yearly total of submitted proposals--from 69 in FY 2002 to 182 this year--while the number of projects funded has actually decreased from a program high of 57 in FY 2004. The overall effect of this trend has helped ensure an increasingly competitive program that benefited from a broader set of innovative ideas, making project selection both challenging and rewarding. Proposals were evaluated for technical merit, including such factors as innovation, probability of success, potential benefit, and mission applicability. Authors and reviewers benefited from the use of a shortfalls list entitled the 'NTS Technology Needs Assessment' that was compiled from NTS, National Weapons Laboratory (NWL

  13. Nevada Test Site-Directed Research and Development, FY 2007 Report

    Energy Technology Data Exchange (ETDEWEB)

    Wil Lewis, editor

    2008-02-20

    The Nevada Test Site-Directed Research and Development (SDRD) program completed a very successful year of research and development activities in FY 2007. Twenty-nine new projects were selected for funding this year, and eight projects started in FY 2006 were brought to conclusion. The total funds expended by the SDRD program were $5.67 million, for an average per-project cost of $153 thousand. An external audit conducted in September 2007 verified that appropriate accounting practices were applied to the SDRD program. Highlights for the year included: programmatic adoption of 8 SDRD-developed technologies; the filing of 9 invention disclosures for innovation evolving from SDRD projects; participation in the tri-Lab Laboratory Directed Research and Development (LDRD) and SDRD Symposium that was broadly attended by Nevada Test Site (NTS), National Nuclear Security Administration (NNSA), LDRD, U.S. Department of Homeland Security (DHS), and U.S. Department of Defense (DoD) representatives; peer reviews of all FY 2007 projects; and the successful completion of 37 R&D projects, as presented in this report. In response to a company-wide call, authors throughout the NTS complex submitted 182 proposals for FY 2007 SDRD projects. The SDRD program has seen a dramatic increase in the yearly total of submitted proposals--from 69 in FY 2002 to 182 this year--while the number of projects funded has actually decreased from a program high of 57 in FY 2004. The overall effect of this trend has helped ensure an increasingly competitive program that benefited from a broader set of innovative ideas, making project selection both challenging and rewarding. Proposals were evaluated for technical merit, including such factors as innovation, probability of success, potential benefit, and mission applicability. Authors and reviewers benefited from the use of a shortfalls list entitled the 'NTS Technology Needs Assessment' that was compiled from NTS, National Weapons Laboratory

  14. Nevada Test Site-Directed Research and Development: FY 2006 Report

    Energy Technology Data Exchange (ETDEWEB)

    Wil Lewis, editor

    2007-08-01

    The Nevada Test Site–Directed Research and Development (SDRD) program completed its fifth successful year of research and development activities in FY 2006. Forty new projects were selected for funding this year, and ten FY 2005 projects were brought to conclusion. The total funds expended by the SDRD program were $6 million, for an average per-project cost of $120 thousand. Beginning in May, 2006 programmatic burden rates were applied to SDRD project costs. An external audit conducted in September 2006 verified that appropriate accounting practices were applied to the SDRD program. Highlights for the year included: the filing of 27 invention disclosures for intellectual property generated by FY 2006 projects; programmatic adoption of four FY 2005 SDRD-developed technologies; participation in the tri-Lab Laboratory Directed Research and Development (LDRD) and SDRD program review that was broadly attended by NTS, NNSA, LDRD, and U.S. Department of Homeland Security representatives; peer reviews of all FY 2006 projects; and the successful completion of 50 R&D projects, as presented in this report.

  15. Site-directed subsurface environmental initiative: Five year summary and plan for fundamental research in subsoils and in groundwater, FY 1989-FY 1993

    International Nuclear Information System (INIS)

    1987-10-01

    The overall goal of this research initiative is to develop the necessary scientific basis for resolution of key technical obstacles to defining and remediating contamination at DOE and other waste sites. To accomplish this goal, the resouces of the national laboratories, universities, and DOE sites will be fully utilized to develop and demonstrate improved, cost-effective, and environmentally acceptable techniques for predicting the behavior of contaminants and reducing their concentrations in ground water. This document is a preliminary plan to set general research directions for a program extending into the 1990s. The needs and milestones identified in this plan may change with additional guidance from DOE sites. Promising research opportunities will be identified as part of national laboratory submissions of preliminary proposals

  16. Modeling membrane protein structure through site-directed ESR spectroscopy

    NARCIS (Netherlands)

    Kavalenka, A.A.

    2009-01-01

    Site-directed spin labeling (SDSL) electron spin resonance (ESR) spectroscopy is a
    relatively new biophysical tool for obtaining structural information about proteins. This
    thesis presents a novel approach, based on powerful spectral analysis techniques (multicomponent
    spectral

  17. LIDAR Research & Development Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The LIDAR Research and Development labs are used to investigate and improve LIDAR components such as laser sources, optical signal detectors and optical filters. The...

  18. Photovoltaic research and development

    CSIR Research Space (South Africa)

    Cummings, F

    2009-09-01

    Full Text Available Photovoltaic (PV) is the direct conversion of sunlight into electrical energy through a solar cell. This presentation consists of an introduction to photovoltaics, the South African PV research roadmap, a look at the CSIR PV research and development...

  19. Space biology research development

    Science.gov (United States)

    Bonting, Sjoerd L.

    1993-01-01

    The purpose of the Search for Extraterrestrial Intelligence (SETI) Institute is to conduct and promote research related activities regarding the search for extraterrestrial life, particularly intelligent life. Such research encompasses the broad discipline of 'Life in the Universe', including all scientific and technological aspects of astronomy and the planetary sciences, chemical evolution, the origin of life, biological evolution, and cultural evolution. The primary purpose was to provide funding for the Principal Investigator to collaborate with the personnel of the SETI Institute and the NASA-Ames Research center in order to plan and develop space biology research on and in connection with Space Station Freedom; to promote cooperation with the international partners in the space station; to conduct a study on the use of biosensors in space biology research and life support system operation; and to promote space biology research through the initiation of an annual publication 'Advances in Space Biology and Medicine'.

  20. Mechanism of adenylate kinase: Site-directed mutagenesis versus x-ray and NMR

    International Nuclear Information System (INIS)

    Tsai, Mingdaw; Yan, Honggao

    1991-01-01

    Controversy is an integral part of scientific research and is often a precursor to the truth. However, this lesson has been learned in a very hard way in the case of the structure-function relationship of adenylate kinase (AK), which catalyzes the interconversion between MgATP+AMP and MgADP+ADP. While this small kinase has been considered a model kinase and the enzyme-substrate interaction of AK was among the first investigated by X-ray crystallography and NMR the substrate binding sites deduced from the early studies by these two powerful techniques (termed the X-ray model and the NMR model, respectively) were dramatically different. Ironically, both models have had substantial impact on researchers in related fields. The problems have finally been dealt with since 1987 by the interplay between site-directed mutagenesis, X-ray, and NMR. The purpose of this review is not only to summarize the current knowledge in the structure-function relationship of adenylate kinase but also to accurately document and critically analyze historical developments in the hope that history will not be repeated

  1. Research and development

    Energy Technology Data Exchange (ETDEWEB)

    Harlow, Jr, J G

    1977-09-01

    The need for increased research and development programs to provide technological advances to meet future energy demands, particularly electric power demands, is discussed. It is concluded that the future energy needs of the world can only be supplied through technological improvements. The cost of these technological improvements can be minimized by cooperative, unified research and development programs. The financial support of the energy industry, the equipment manufacturing industry and the consumer will be required to finance these vital developments. The energy problems of the world can be solved by an adequately financed unified R and D effort. The U.S. must assume a major role of leadership in this world-wide effort. (LCL)

  2. Software-Supported USER Cloning Strategies for Site-Directed Mutagenesis and DNA Assembly

    DEFF Research Database (Denmark)

    Genee, Hans Jasper; Bonde, Mads Tvillinggaard; Bagger, Frederik Otzen

    2015-01-01

    USER cloning is a fast and versatile method for engineering of plasmid DNA. We have developed a user friendly Web server tool that automates the design of optimal PCR primers for several distinct USER cloning-based applications. Our Web server, named AMUSER (Automated DNA Modifications with USER...... cloning), facilitates DNA assembly and introduction of virtually any type of site-directed mutagenesis by designing optimal PCR primers for the desired genetic changes. To demonstrate the utility, we designed primers for a simultaneous two-position site-directed mutagenesis of green fluorescent protein...... (GFP) to yellow fluorescent protein (YFP), which in a single step reaction resulted in a 94% cloning efficiency. AMUSER also supports degenerate nucleotide primers, single insert combinatorial assembly, and flexible parameters for PCR amplification. AMUSER is freely available online at ....

  3. Technological advances in site-directed spin labeling of proteins.

    Science.gov (United States)

    Hubbell, Wayne L; López, Carlos J; Altenbach, Christian; Yang, Zhongyu

    2013-10-01

    Molecular flexibility over a wide time range is of central importance to the function of many proteins, both soluble and membrane. Revealing the modes of flexibility, their amplitudes, and time scales under physiological conditions is the challenge for spectroscopic methods, one of which is site-directed spin labeling EPR (SDSL-EPR). Here we provide an overview of some recent technological advances in SDSL-EPR related to investigation of structure, structural heterogeneity, and dynamics of proteins. These include new classes of spin labels, advances in measurement of long range distances and distance distributions, methods for identifying backbone and conformational fluctuations, and new strategies for determining the kinetics of protein motion. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Hydropower research and development

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    This report is a compilation of information on hydropower research and development (R and D) activities of the Federal government and hydropower industry. The report includes descriptions of on-going and planned R and D activities, 1996 funding, and anticipated future funding. Summary information on R and D projects and funding is classified into eight categories: fish passage, behavior, and response; turbine-related; monitoring tool development; hydrology; water quality; dam safety; operations and maintenance; and water resources management. Several issues in hydropower R and D are briefly discussed: duplication; priorities; coordination; technical/peer review; and technology transfer/commercialization. Project information sheets from contributors are included as an appendix.

  5. Photonics Research and Development

    Energy Technology Data Exchange (ETDEWEB)

    Dickson, Elizabeth [UNLV Research Foundation, Las Vegas, NV (United States)

    2010-01-15

    During the period August 2005 through October 2009, the UNLV Research Foundation (UNLVRF), a non-profit affiliate of the University of Nevada, Las Vegas (UNLV), in collaboration with UNLV's Colleges of Science and Engineering; Boston University (BU); Oak Ridge National Laboratory (ORNL); and Sunlight Direct, LLC, has managed and conducted a diverse and comprehensive research and development program focused on light-emitting diode (LED) technologies that provide significantly improved characteristics for lighting and display applications. This final technical report provides detailed information on the nature of the tasks, the results of the research, and the deliverables. It is estimated that about five percent of the energy used in the nation is for lighting homes, buildings and streets, accounting for some 25 percent of the average home's electric bill. However, the figure is significantly higher for the commercial sector. About 60 percent of the electricity for businesses is for lighting. Thus replacement of current lighting with solid-state lighting technology has the potential to significantly reduce this nation's energy consumption by some estimates, possibly as high as 20%. The primary objective of this multi-year R&D project has been to develop and advance lighting technologies to improve national energy conversion efficiencies; reduce heat load; and significantly lower the cost of conventional lighting technologies. The UNLVRF and its partners have specifically focused these talents on (1) improving LED technologies; (2) optimizing hybrid solar lighting, a technology which potentially offers the benefits of blending natural with artificial lighting systems, thus improving energy efficiency; and (3) building a comprehensive academic infrastructure within UNLV which concentrates on photonics R&D. Task researchers have reported impressive progress in (1) the development of quantum dot laser emitting diodes (QDLEDs) which will ultimately improve

  6. Ecotribology research developments

    CERN Document Server

    2016-01-01

    This book presents resent research advances in the area of eco-triobology. In the last years, eco-tribology or environmentally friendly tribology has gained increasing importance in sustainable engineering. Environmentally acceptable tribological practices save resources by optimizing product usage and reducing energy. This book covers current developments in all areas covered by the term eco-tribology, including biomimetics surfaces, control of friction and wear, environmental aspects of lubrication and surface modification techniques as well as tribological aspects of green applications, such wind-power turbines or solar panels.

  7. Research and development experience

    International Nuclear Information System (INIS)

    Slater, J.B.

    1980-06-01

    In the early 1950s, Atomic Energy of Canada Limited (AECL), in collaboration with Canadian industry and the power utilities, started on the task of developing and establishing the CANDU power reactor system and the necessary industrial infrastructure. While international activity provided a useful background and information to support Canadian activities, there were several unique features of the CANDU reactor which demanded specific programs of research and development work with a physics orientation. The four major areas were basic reactor physics, reactor control, heavy water and tritium monitoring and instruments and, finally, the potential of alternative fuel cycles. These four topics are discussed with the objective of providing an overview of what has been accomplished and what remains to be done. (auth)

  8. Technology research and development

    International Nuclear Information System (INIS)

    Haas, G.M.; Abdov, M.A.; Baker, C.C.; Beuligmann, R.F.

    1985-01-01

    The U.S. Dept. of Energy discusses the new program plan, the parameters of which are a broad scientific and technology knowledge base, an attractive plasma configuration to be determined, and other issues concerning uncertainty as to what constitutes attractive fusion options to be determined in the future, and increased collaboration. Tables show changing directions in magnetic fusion energy, two examples of boundary condition impacts on long-term technology development, and priority classes of the latter. The Argonne National Laboratory comments on the relationship between science, technology and the engineering aspects of the fusion program. UCLA remarks on the role of fusion technology in the fusion program plan, particularly on results from the recent studies of FINESSE. General Dynamics offers commentary on the issues of a reduced budget, and new emphasis on science which creates an image of the program. A table illustrates technology research and development in the program plan from an industrial perspective

  9. Research tools | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Through training materials and guides, we aim to build skills and knowledge to enhance the quality of development research. We also offer free access to our database of funded research projects, known as IDRIS+, and our digital library. Our research tools include. Guide to research databases at IDRC: How to access and ...

  10. Changing Research Practices and Research Infrastructure Development

    Science.gov (United States)

    Houghton, John W.

    2005-01-01

    This paper examines changing research practices in the digital environment and draws out implications for the development of research infrastructure. Reviews of the literature, quantitative indicators of research activities and our own field research in Australia suggest that there is a new mode of knowledge production emerging, changing research…

  11. Eltron Research & Development

    Energy Technology Data Exchange (ETDEWEB)

    Evenson, Carl; Mackay, Richard; Faull, John

    2014-03-01

    This topical report covers technical work conducted under contract DE-FC26-05NT42469 between FY06 Q1 through FY14 Q2. The project evolved through several budget periods, budget revisions and continuation applications. This report covers work performed under the “base” program. In 2010 ARRA funding was added to the project. A separate report covering the ARRA portion of the project was submitted to DOE. The original project was focused on research and development for scale-up of hydrogen separation membrane for a FutureGen type power plant. The work included membrane testing and evaluation of metal alloy flat plates vs. tubes and metal membranes vs. cermet membranes. In addition, economic analysis and process modeling was performed. The original project team included CoorsTek, NORAM, and Praxair. In FY10Q2 a continuation application was filed for conducting a scale-up test at Eastman Chemical. In this part of the project a Subscale Engineering Prototype (SEP) membrane skid was designed, fabricated, and operated on a gasified coal slip-stream on Eastman’s site in Kingsport, TN. Following operation, the project was reorganized and a second continuation application with a new statement of work was initiated in FY12Q1. Finally, based on DOE’s decision not to proceed with a Process Development Unit (PDU) field test, a third continuation application and statement of work was initiated in FY13Q1 to close out the project.

  12. Tetragonal Lysozyme Interactions Studied by Site Directed Mutagenesis

    Science.gov (United States)

    Crawford, Lisa; Karr, Laurel J.; Nadarajah, Arunan; Pusey, Marc

    1999-01-01

    A number of recent experimental and theoretical studies have indicated that tetragonal lysozyme crystal growth proceeds by the addition of aggregates, formed by reversible self association of the solute molecules in the bulk solution. Periodic bond chain and atomic force microscopy studies have indicated that the probable growth unit is at minimum a 43 tetramer, and most likely an octamer composed of two complete turns about the 43 axis. If these results are correct, then there are intermolecular interactions which are only formed in the solution and others only formed at the joining of the growth unit to the crystal surface. We have set out to study these interactions, and the correctness of this hypothesis, using site directed mutagenesis of specific amino acid residues involved in the different bonds. We had initially expressed wild type lysozyme in S. cervasiae with yields of approximately 5 mg/L, which were eventually raised to approximately 40 mg/L. We are now moving the expression to the Pichia system, with anticipated yields of 300 to (3)500 mg/L, comparable to what can be obtained from egg whites. An additional advantage of using recombinant protein is the greater genetic homogeneity of the material obtained and the absence of any other contaminating egg proteins. The first mutation experiments are TYR 23 (Registered) PHE or ALA and ASN 113 (Registered) ALA or ASP. Both TYR 23 and ASN 113 form part of the postulated dimerization intermolecular binding site which lead to the formation of the 43 helix. Tyrosine also participates in an intermolecular hydrogen bond with ARG 114. The results of these and subsequent experiments will be discussed.

  13. International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... development. Learn moreArtificial intelligence and human development ... New initiative will match climate knowledge to developing country needs. Aminata Camara ... Shadow Libraries: Access to Knowledge in Global Higher Education.

  14. Research Librarian | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Job Summary The Research Librarian is a key member of a team responsible for the delivery of comprehensive research information services which contribute strategic value to the work of clients. Intermediated search services at the expert level, the development and delivery of orientations, training/coaching, ...

  15. International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ann Gregory

    further development of scientific agriculture and technology. Already, however ..... sent, starting in the north, to Galilee and the regions adjoining, Lebanon and Syria, and working my ... the water, grow crops, and flocks of sheep and goats.” He says ... I served in 30 or 40 different countries throughout Asia and Africa, South.

  16. Offshore wind development research.

    Science.gov (United States)

    2014-04-01

    Offshore wind (OSW) development is a new undertaking in the US. This project is a response to : New Jerseys 2011 Energy Master Plan that envisions procuring 22.5% of the states power : originating from renewable sources by 2021. The Offshore Wi...

  17. Translational Research and Youth Development

    Science.gov (United States)

    Hamilton, Stephen F.

    2015-01-01

    Borrowing the term "translational research" (TR) from medicine, along with some of the ideas and practices that define it, holds promise as a way of linking research more closely to the practice of youth development. However, doing so entails substantial adaptation. TR is more than a new name for applied research. It comprehends the…

  18. Ethiopian Journal of Development Research

    African Journals Online (AJOL)

    Log in or Register to get access to full text downloads. ... The Ethiopian Journal of Development Research (EJDR) is a bi-annual journal devoted to ... It is devoted to the multi-disciplinary study of development problems of Ethiopia in particular ... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

  19. Provincial resource development research policy

    Energy Technology Data Exchange (ETDEWEB)

    Flock, D L

    1976-01-01

    In Alberta, there is an abundance of oil, natural gas, and coal. But only a small portion of the Alberta oil sands and coal resources are commercially accessible to surface-mining techniques. It is quite apparent that some in-situ technological breakthrough will be required, which will mean a concerted research effort at the provincial level. It is the purpose of this paper to present certain concepts and recommendations for a coordinated provincial resource development research policy for the Province of Alberta. Research as discussed in this paper covers basic and applied research and development. (MCW)

  20. Research and development toward Monju

    International Nuclear Information System (INIS)

    Nakamoto, Koichiro; Ikegami, Tetsuo; Sikakura, Sakae; Iwata, Koji; Yamaguchi, Katsuhisa; Kodaira, Kiyoshi

    1994-01-01

    Power Reactor and Nuclear Fuel Development Corporation aimed at the development of the experimental FBR ''Joyo'' and the prototype FBR ''Monju'', and has promoted the research and development of respective fields of reactor physics, shielding, fuel, safety, sodium technology, machinery and equipment, structural materials, measurement and control by cooperating with Japan Atomic Energy Research Institute, universities, national and public research institutes, electric power and manufacturing companies. Also the promotion of the development by international cooperation has been carried out positively. As for the core and fuel, the Japan-UK joint research ''MOZART project'' for the increase of reactor power output and the heightening of fuel burnup, and the test of MOX fuel, as for machinery, equipment and structure, the rationalization of structural design, the development of steam generator, the test with sodium testing facility, and as for safety, the test on the events related to the core, decay heat removing system and containment system were carried out. (K.I.)

  1. Revised Mechanism and Improved Efficiency of the QuikChange Site-Directed Mutagenesis Method.

    Science.gov (United States)

    Xia, Yongzhen; Xun, Luying

    2017-01-01

    Site-directed mutagenesis has been widely used for the substitution, addition or deletion of nucleotide residues in a defined DNA sequence. QuikChange™ site-directed mutagenesis and its related protocols have been widely used for this purpose because of convenience and efficiency. We have recently demonstrated that the mechanism of the QuikChange™ site-directed mutagenesis process is different from that being proposed. The new mechanism promotes the use of partially overlapping primers and commercial PCR enzymes for efficient PCR and mutagenesis.

  2. Research and development of CRIEPI

    International Nuclear Information System (INIS)

    Akita, Shirabe

    2008-01-01

    Central Research Institute of Electric Power Industry (CRIEPI) reported its R and D of nuclear power technologies. The research results of light water reactor aging deterioration contain the estimation method of irradiation embrittlement of pressure vessel, stress corrosion cracking of piping and core internal structure, and pipe thinning. The backend project support researches include transpiration and storage of recycle fuel, the high-level radioactive waste disposal and low-level radioactive waste disposal. Safety of concrete cask storage was confirmed by the falling test, SCC test and vibration test. The researches for the next generation nuclear technologies have developed the pyrochemical reprocessing process for the metal fuel and oxide fuel, and development of metal fuel with U, Pu and Zr. Assist management of development of fast reactor is proceeding. One of researches of radiation safety is on low dose X-ray bystander effect on the diabetes mellitus of model mouse. (S.Y.)

  3. Cancer Research UK | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cancer Research UK. Cancer Research UK. https://www.cancerresearchuk.org/. The Economics of Tobacco Control Research Initiative. The Economics of Tobacco Control Research Initiative funds innovative fiscal policy research supporting tobacco control in low and middle-income countries. View more. The Economics ...

  4. Facile Site-Directed Mutagenesis of Large Constructs Using Gibson Isothermal DNA Assembly.

    Science.gov (United States)

    Yonemoto, Isaac T; Weyman, Philip D

    2017-01-01

    Site-directed mutagenesis is a commonly used molecular biology technique to manipulate biological sequences, and is especially useful for studying sequence determinants of enzyme function or designing proteins with improved activity. We describe a strategy using Gibson Isothermal DNA Assembly to perform site-directed mutagenesis on large (>~20 kbp) constructs that are outside the effective range of standard techniques such as QuikChange II (Agilent Technologies), but more reliable than traditional cloning using restriction enzymes and ligation.

  5. Fundamental research in developing countries

    International Nuclear Information System (INIS)

    Moravesik, M.J.

    1964-01-01

    Technical assistance is today a widespread activity. Large numbers of persons with special qualifications in the applied sciences go to the developing countries to work on specific research and development projects, as do educationists on Fulbright or other programmes - usually to teach elementary or intermediate courses. But I believe that until now it has been rare for a person primarily interested in fundamental research to go to one of these countries to help build up advanced education and pure research work. Having recently returned from such an assignment, and having found it a most stimulating and enlightening experience, I feel moved to urge strongly upon others who may be in a position to do so that they should seek similar experience themselves. The first step is to show that advanced education and fundamental research are badly needed in the under-developed countries.

  6. Development research: The environmental challenge

    International Nuclear Information System (INIS)

    Winpenny, J.T.

    1991-01-01

    This book represents papers from a 1990 conference 'The environment, Development and Economic Research'. The focus of the book is the environmental and natural resource use problems, though economic development is a strong co-theme. Chapters cover the following topic areas: international issues; macroeconomic policies; natural resource degradation; urban problems; social dimensions; bio-diversity; energy; economic valuation

  7. Nuclear safeguards research and development

    Science.gov (United States)

    Henry, C. N.

    1981-11-01

    The status of a nuclear safeguard research and development program is presented. Topics include nondestructive assay technology development and applications, international safeguards, training courses, technology transfer, analytical chemistry methods for fissionable materials safeguards, the Department of Energy Computer Security Technical Center, and operational security.

  8. Research and development program 1985

    International Nuclear Information System (INIS)

    1984-01-01

    In this report the research and development program of the GSI Darmstadt is described. It concerns heavy ion reactions, nuclear structure studies, exotic nuclei, nuclear theory, atomic collisions with heavy ions, atomic spectroscopy, the interaction of heavy ions with matter, atomic theory, biological studies with heavy ions, nuclear track techniques, UNILAC developments, acquisition of experimental data, and the development of new accelerators, ion sources, targets, and detectors. (HSI) [de

  9. Doctoral research on cadastral development

    DEFF Research Database (Denmark)

    Cagdas, Volkan; Stubkjær, Erik

    2009-01-01

    of the countries concerned. The cadastre, however, is the core of both systems as it provides for systematic and official descriptions of land parcels or real property units. The research mentioned often has a development perspective, and in this article we will motivate the introduction of the research domain...... of cadastral development. This research is multi-disciplinary and draws on elements of theories and methodologies from the natural, the social, the behavioral, and the formal sciences. During the last decade or so, doctoral dissertations have come to constitute a substantial part of this research effort...... with a call for a shared terminology and a shared set of concepts which may contribute to further theory building within the cadastral domain. Udgivelsesdato: OCT...

  10. UCLA accelerator research and development

    International Nuclear Information System (INIS)

    Cline, D.B.

    1992-01-01

    This progress report covers work supported by the above DOE grant over the period November 1, 1991 to July 31, 1992. The work is a program of experimental and theoretical studies in advanced particle accelerator research and development for high energy physics applications. The program features research at particle beam facilities in the United States and includes research on novel high power sources, novel focussing systems (e.g. plasma lens), beam monitors, novel high brightness, high current gun systems, and novel flavor factories in particular the φ Factory

  11. NGNP Research and Development Status

    Energy Technology Data Exchange (ETDEWEB)

    David A. Petti

    2010-08-01

    At the inception of the Next Generation Nuclear Plant (NGNP) project, experts from the Department of Energy (DOE) national laboratories, gas reactor vendors, and universities collaborated to establish technology research and development (R&D) roadmaps. These roadmaps outlined the testing and computational development activities needed to qualify the materials and validate the modeling and simulation tools to be used in the design and safe operation of the NGNP, a helium-cooled, high temperature gas reactor (HTGR).

  12. Developing Effective Undergraduate Research Experience

    Science.gov (United States)

    Evans, Michael; Ilie, Carolina C.

    2011-03-01

    Undergraduate research is a valuable educational tool for students pursuing a degree in physics, but these experiences can become problematic and ineffective if not handled properly. Undergraduate research should be planned as an immersive learning experience in which the student has the opportunity to develop his/her skills in accordance with their interests. Effective undergraduate research experiences are marked by clear, measurable objectives and frequent student-professor collaboration. These objectives should reflect the long and short-term goals of the individual undergraduates, with a heightened focus on developing research skills for future use. 1. Seymour, E., Hunter, A.-B., Laursen, S. L. and DeAntoni, T. (2004), ``Establishing the benefits of research experiences for undergraduates in the sciences: First findings from a three-year study''. Science Education, 88: 493--534. 2. Behar-Horenstein, Linda S., Johnson, Melissa L. ``Enticing Students to Enter Into Undergraduate Research: The Instrumentality of an Undergraduate Course.'' Journal of College Science Teaching 39.3 (2010): 62-70.

  13. Suborbital Research and Development Opportunities

    Science.gov (United States)

    Davis, Jeffrey R.

    2011-01-01

    This slide presentation reviews the new strategies for problem solving in the life sciences in the suborbital realm. Topics covered are: an overview of the space life sciences, the strategic initiatives that the Space Life Sciences organization engaged in, and the new business model that these initiatives were developed. Several opportunities for research are also reviewed.

  14. New laser research and development

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    New types of lasers must be developed to provide the desired energy per pulse, pulse length, pulse shape, wavelength, and efficiency for laser-fusion applications. This advanced laser research has focused on rare-gas oxides and on Hg 2 excimers

  15. Global research and development budget

    Energy Technology Data Exchange (ETDEWEB)

    Norman, C

    1980-03-01

    The future political and economic relationships between industrial countries and between the industrial and developing countries will be influenced by the investments now being made for research and development (R and D). There is little public understanding of this $150 billion global investment, 25 percent of which is spent on military programs, 15 percent on basic research, and nearly 10 percent on space exploration, while the most-pressing world problems are receiving relatively little attention. A breakdown of geographic distribution of research and a comparison of government expenditures for different areas of R and D reveals a situation that could be corrected. National and corporate priorities need to be revised and political and institutional barriers must give way to new international and cooperative arrangements. 3 tables, 27 references. (DCK)

  16. Classroom Research and Professional Development

    Directory of Open Access Journals (Sweden)

    Omaira Vergara Luján

    2009-04-01

    Full Text Available This article intends to share the experience of a group of teachers in the Classroom Research Seminar of the Teacher Development Program in English carried out at Universidad del Valle, Cali, from January to June, 2007. The seminar was part of a high-level in-service program for teachers of English of a network of private educational institutions. We would like to share the highlights and difficulties of the experience. We will start with the general framework of the program and the concept of professional development that underlies it. Next we will focus on the classroom research seminar, its objectives, methodology and results. Finally we share the voices of some of the participants, who talk about the influence this seminar had on their professional development and daily work.

  17. Engineering research, development and technology

    International Nuclear Information System (INIS)

    1994-05-01

    The mission of the Engineering Research, Development, and Technology Program at Lawrence Livermore National Laboratory (LLNL) is to develop the technical staff, tools, and facilities needed to support current and future LLNL programs. The efforts are guided by a dual-benefit research and development strategy that supports Department of Energy missions, such as national security through nuclear deterrence and economic competitiveness through partnerships with U.S. industry. This annual report, organized by thrust area, describes the activities for the fiscal year 1993. The report provides timely summaries of objectives, methods, and results from nine thrust areas for this fiscal year: Computational Electronics and Electromagnetics; Computational Mechanics; Diagnostics and Microelectronics; Fabrication Technology; Materials Science and Engineering; Power Conversion Technologies; Nondestructive Evaluation; Remote Sensing, Imaging, and Signal Engineering; and Emerging Technologies. Separate abstracts were prepared for 47 papers in this report

  18. Internationalization of Research and Development

    DEFF Research Database (Denmark)

    Håkanson, Lars

    2014-01-01

    with geographically dispersed and organizationally decentralized R&D. A simple typology of foreign R&D units is presented, emphasizing that the opportunities and challenges vary with the nature of their tasks, which range from technical support and local adaptation of products and processes to product development and......, in some cases, applied and basic research. Managerial systems, procedures, and practices for coordination and control of internationally decentralized R&D are identified, along with mechanisms promoting knowledge management, problem solving, and innovation....

  19. Multiple Site-Directed and Saturation Mutagenesis by the Patch Cloning Method.

    Science.gov (United States)

    Taniguchi, Naohiro; Murakami, Hiroshi

    2017-01-01

    Constructing protein-coding genes with desired mutations is a basic step for protein engineering. Herein, we describe a multiple site-directed and saturation mutagenesis method, termed MUPAC. This method has been used to introduce multiple site-directed mutations in the green fluorescent protein gene and in the moloney murine leukemia virus reverse transcriptase gene. Moreover, this method was also successfully used to introduce randomized codons at five desired positions in the green fluorescent protein gene, and for simple DNA assembly for cloning.

  20. Cooperation in research and development

    International Nuclear Information System (INIS)

    Ramanna, R.

    1977-01-01

    In planning scientific programs for rapid and extensive peaceful applications of atomic energy in any developing country, it is not fully realized that one of the most important inputs is a strong research and development (R and D) base with a well-oriented training program. The paper discusses the various ways in which R and D is required to assist in both indigenous and turnkey projects. The R and D organization should be broad based; i.e., it should have physicists, chemists (particularly specialists in water chemistry), health physicists, and engineers (particularly metallurgists for materials development, study of corrosion problems, etc.). The role of electronic engineers is also very significant from the viewpoint of designing reactor control systems. Another important advantage of having an R and D program is its general technological fallout, which aids the entire industrial structure of the country. The concept of regional cooperation is very important, particularly for atomic energy programs in developing countries that have similar conditions and levels of technological skills. This cooperation can be bilateral or multilateral under the auspices of the International Atomic Energy Agency. Scientists from several countries have been trained in our Center, and we also had a very successful India-Philippines-Agency Project in which scientists from many countries in the region participated in cooperative research programs

  1. Advanced accelerator research and development

    International Nuclear Information System (INIS)

    Anon.

    1974-01-01

    Research and development on the Positron-Electron Project (PEP), the electron rings, the superconducting accelerator (ESCAR), and the superconductivity program are reported. Efforts relating to the proposed PEP include work on: (1) the injection system; (2) the rf system; (3) the main-ring bend magnets; (4) the magnet power supplies and controls; (5) alignment; (6) radiation and shielding; (7) the vacuum system; and (8) conventional facilities (utilities, etc.). Experimental and theoretical work continued on the development of suitably intense electron rings as vehicles for the collective acceleration of ions. The most difficult problem was found to be the longitudinal (negative mass) instability. Design work was begun for ESCAR (Experimental Superconducting Accelerating Ring), a small proton synchrotron and storage ring using superconducting magnets, which should aid in the design of future large superconducting facilities. Magnet development was largely directed toward the detailed design of the dipole units. A superconducting beam transport line was installed at the Bevatron. (PMA)

  2. Site-Directed Mutagenesis Study Revealed Three Important Residues in Hc-DAF-22, a Key Enzyme Regulating Diapause of Haemonchus contortus

    Directory of Open Access Journals (Sweden)

    Yan Huang

    2017-11-01

    Full Text Available Haemonchus contortus (H. contortus is one of the most important parasites of small ruminants, especially goats and sheep. The complex life cycle of this nematode is a main obstacle for the control and prevention of haemonchosis. So far, a special form of arrested development called diapause different from the dauer stage in Caenorhabditis elegans (C. elegans has been found in many parasitic nematodes. In our previous study, we have characterized a novel gene Hc-daf-22 from H. contortus sharing high homology with Ce-daf-22 and functional analysis showed this gene has similar biological function with Ce-daf-22. In this study, Hc-daf-22 mutants were constructed using site-directed mutagenesis, and carried out rescue experiments, RNA interference (RNAi experiments and in vitro enzyme activity analysis with the mutants to further explore the precise function site of Hc-DAF-22. The results showed that Hc-daf-22 mutants could be expressed in the rescued ok693 worms and the expression positions were mainly in the intestine which was identical with that of Hc-daf-22 rescued worms. Through lipid staining we found that Hc-daf-22 could rescue daf-22 mutant (ok693 from the fatty acid metabolism deficiency while Hc-daf-22 mutants failed. Brood size and body length analyses in rescue experiment along with body length and life span analyses in RNAi experiment elucidated that Hc-daf-22 resembled Ce-daf-22 in effecting the development and capacity of C. elegans and mutants impaired the function of Hc-daf-22. Together with the protease activity assay, this research revealed three important active resides 84C/299H/349H in Hc-DAF-22 by site-directed mutagenesis.

  3. Site-Directed Mutagenesis Study Revealed Three Important Residues in Hc-DAF-22, a Key Enzyme Regulating Diapause of Haemonchus contortus.

    Science.gov (United States)

    Huang, Yan; Zheng, Xiuping; Zhang, Hongli; Ding, Haojie; Guo, Xiaolu; Yang, Yi; Chen, Xueqiu; Zhou, Qianjin; Du, Aifang

    2017-01-01

    Haemonchus contortus ( H. contortus ) is one of the most important parasites of small ruminants, especially goats and sheep. The complex life cycle of this nematode is a main obstacle for the control and prevention of haemonchosis. So far, a special form of arrested development called diapause different from the dauer stage in Caenorhabditis elegans ( C. elegans ) has been found in many parasitic nematodes. In our previous study, we have characterized a novel gene Hc-daf-22 from H. contortus sharing high homology with Ce-daf-22 and functional analysis showed this gene has similar biological function with Ce-daf-22 . In this study, Hc-daf-22 mutants were constructed using site-directed mutagenesis, and carried out rescue experiments, RNA interference (RNAi) experiments and in vitro enzyme activity analysis with the mutants to further explore the precise function site of Hc-DAF-22. The results showed that Hc-daf-22 mutants could be expressed in the rescued ok693 worms and the expression positions were mainly in the intestine which was identical with that of Hc-daf-22 rescued worms. Through lipid staining we found that Hc-daf-22 could rescue daf-22 mutant ( ok693 ) from the fatty acid metabolism deficiency while Hc-daf-22 mutants failed. Brood size and body length analyses in rescue experiment along with body length and life span analyses in RNAi experiment elucidated that Hc-daf-22 resembled Ce-daf-22 in effecting the development and capacity of C. elegans and mutants impaired the function of Hc-daf-22 . Together with the protease activity assay, this research revealed three important active resides 84C/299H/349H in Hc-DAF-22 by site-directed mutagenesis.

  4. Advanced Research Reactor Fuel Development

    Energy Technology Data Exchange (ETDEWEB)

    Kim, C. K.; Park, H. D.; Kim, K. H. (and others)

    2006-04-15

    RERTR program for non-proliferation has propelled to develop high-density U-Mo dispersion fuels, reprocessable and available as nuclear fuel for high performance research reactors in the world. As the centrifugal atomization technology, invented in KAERI, is optimum to fabricate high-density U-Mo fuel powders, it has a great possibility to be applied in commercialization if the atomized fuel shows an acceptable in-reactor performance in irradiation test for qualification. In addition, if rod-type U-Mo dispersion fuel is developed for qualification, it is a great possibility to export the HANARO technology and the U-Mo dispersion fuel to the research reactors supplied in foreign countries in future. In this project, reprocessable rod-type U-Mo test fuel was fabricated, and irradiated in HANARO. New U-Mo fuel to suppress the interaction between U-Mo and Al matrix was designed and evaluated for in-reactor irradiation test. The fabrication process of new U-Mo fuel developed, and the irradiation test fuel was fabricated. In-reactor irradiation data for practical use of U-Mo fuel was collected and evaluated. Application plan of atomized U-Mo powder to the commercialization of U-Mo fuel was investigated.

  5. Development Model for Research Infrastructures

    Science.gov (United States)

    Wächter, Joachim; Hammitzsch, Martin; Kerschke, Dorit; Lauterjung, Jörn

    2015-04-01

    Research infrastructures (RIs) are platforms integrating facilities, resources and services used by the research communities to conduct research and foster innovation. RIs include scientific equipment, e.g., sensor platforms, satellites or other instruments, but also scientific data, sample repositories or archives. E-infrastructures on the other hand provide the technological substratum and middleware to interlink distributed RI components with computing systems and communication networks. The resulting platforms provide the foundation for the design and implementation of RIs and play an increasing role in the advancement and exploitation of knowledge and technology. RIs are regarded as essential to achieve and maintain excellence in research and innovation crucial for the European Research Area (ERA). The implementation of RIs has to be considered as a long-term, complex development process often over a period of 10 or more years. The ongoing construction of Spatial Data Infrastructures (SDIs) provides a good example for the general complexity of infrastructure development processes especially in system-of-systems environments. A set of directives issued by the European Commission provided a framework of guidelines for the implementation processes addressing the relevant content and the encoding of data as well as the standards for service interfaces and the integration of these services into networks. Additionally, a time schedule for the overall construction process has been specified. As a result this process advances with a strong participation of member states and responsible organisations. Today, SDIs provide the operational basis for new digital business processes in both national and local authorities. Currently, the development of integrated RIs in Earth and Environmental Sciences is characterised by the following properties: • A high number of parallel activities on European and national levels with numerous institutes and organisations participating

  6. Taxation of Research and Development

    Directory of Open Access Journals (Sweden)

    Zsuzsanna Szeles

    2016-01-01

    Full Text Available Research and development plays an unquestionably role in terms of long-term growth. According to Eurostat, almost half of all enterprises in the EU-28 reported innovation activity (48.9% during the period 2010-2012. Compared with the period 2008-2010, the share of innovative enterprises decreased by 3.9 percentage points. Among the EU Member States, the highest shares of innovative enterprises during the period 2010–2012 were observed in Germany (66.9 % of all enterprises, and the lowest share was recorded in Romania (20.7%.

  7. Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds.

    Science.gov (United States)

    Tabisz, Barbara; Schmitz, Werner; Schmitz, Michael; Luehmann, Tessa; Heusler, Eva; Rybak, Jens-Christoph; Meinel, Lorenz; Fiebig, Juliane E; Mueller, Thomas D; Nickel, Joachim

    2017-03-13

    The regenerative potential of bone is strongly impaired in pathological conditions, such as nonunion fractures. To support bone regeneration various scaffolds have been developed in the past, which have been functionalized with osteogenic growth factors such as bone morphogenetic proteins (BMPs). However, most of them required supra-physiological levels of these proteins leading to burst releases, thereby causing severe side effects. Site-specific, covalent coupling of BMP2 to implant materials might be an optimal strategy in order to overcome these problems. Therefore, we created a BMP-2 variant (BMP2-K3Plk) containing a noncanonical amino acid (propargyl-l-lysine) substitution introduced by genetic code expansion that allows for site-specific and covalent immobilization onto polymeric scaffold materials. To directly compare different coupling strategies, we also produced a BMP2 variant containing an additional cysteine residue (BMP2-A2C) allowing covalent coupling by thioether formation. The BMP2-K3Plk mutant was coupled to functionalized beads by a copper-catalyzed azide-alkyne cycloaddition (CuAAC) either directly or via a short biotin-PEG linker both with high specificity. After exposing the BMP-coated beads to C2C12 cells, ALP expression appeared locally restricted in close proximity to these beads, showing that both coupled BMP2 variants trigger cell differentiation. The advantage of our approach over non-site-directed immobilization techniques is the ability to produce fully defined osteogenic surfaces, allowing for lower BMP2 loads and concomitant higher bioactivities, for example, due to controlled orientation toward BMP2 receptors. Such products might provide superior bone healing capabilities with potential safety advantages as of homogeneous product outcome.

  8. Participatory Research and Development for Sustainable Agriculture ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Participatory Research and Development for Sustainable Agriculture and Natural Resource Management - A Sourcebook Volume 3 : Doing Participatory Research and Development. Couverture du livre Participatory Research and Development for Sustainable Agriculture and Natural Resource Management : A.

  9. Laboratory directed research and development

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-15

    The purposes of Argonne's Laboratory Directed Research and Development (LDRD) Program are to encourage the development of novel concepts, enhance the Laboratory's R D capabilities, and further the development of its strategic initiatives. Among the aims of the projects supported by the Program are establishment of engineering proof-of-principle''; development of an instrumental prototype, method, or system; or discovery in fundamental science. Several of these project are closely associated with major strategic thrusts of the Laboratory as described in Argonne's Five Year Institutional Plan, although the scientific implications of the achieved results extend well beyond Laboratory plans and objectives. The projects supported by the Program are distributed across the major programmatic areas at Argonne. Areas of emphasis are (1) advanced accelerator and detector technology, (2) x-ray techniques in biological and physical sciences, (3) advanced reactor technology, (4) materials science, computational science, biological sciences and environmental sciences. Individual reports summarizing the purpose, approach, and results of projects are presented.

  10. Software development for research reactors

    International Nuclear Information System (INIS)

    Krohn, J.L.; Feltz, D.E.; Khalil, N.S.

    1986-01-01

    The Texas A and M University Nuclear Science Center, in a program jointly sponsored with the International Atomic Energy Agency, is developing a series of computer software programs of use at research reactor facilities. The programs cover a wide range of topics including activation and shielding calculations, control rod calibrations, power calorimetrics, and fuel inventory including burnup. Many of the programs are modified and improved versions of programs already in use at the NSC that ran on outdated computing equipment. All of the new versions were written in Fortran77 on the NSC's new TI Pro microcomputer and are IBM-compatible. This paper describes the development and translation efforts in preparing the programs for use by other facilities, and gives an overview of the aim of the development effort. A brief description of each program that has been or is to be written is given including the required inputs and the resulting outputs. This paper also addresses the original needs that brought about the development program and the benefits to facility operations that each program provides. The programs discussed are available to interested parties in a hard-copy listing as requested. (author)

  11. Carbon sequestration research and development

    Energy Technology Data Exchange (ETDEWEB)

    Reichle, Dave; Houghton, John; Kane, Bob; Ekmann, Jim; and others

    1999-12-31

    Predictions of global energy use in the next century suggest a continued increase in carbon emissions and rising concentrations of carbon dioxide (CO{sub 2}) in the atmosphere unless major changes are made in the way we produce and use energy--in particular, how we manage carbon. For example, the Intergovernmental Panel on Climate Change (IPCC) predicts in its 1995 ''business as usual'' energy scenario that future global emissions of CO{sub 2} to the atmosphere will increase from 7.4 billion tonnes of carbon (GtC) per year in 1997 to approximately 26 GtC/year by 2100. IPCC also projects a doubling of atmospheric CO{sub 2} concentration by the middle of next century and growing rates of increase beyond. Although the effects of increased CO{sub 2} levels on global climate are uncertain, many scientists agree that a doubling of atmospheric CO{sub 2} concentrations could have a variety of serious environmental consequences. The goal of this report is to identify key areas for research and development (R&D) that could lead to an understanding of the potential for future use of carbon sequestration as a major tool for managing carbon emissions. Under the leadership of DOE, researchers from universities, industry, other government agencies, and DOE national laboratories were brought together to develop the technical basis for conceiving a science and technology road map. That effort has resulted in this report, which develops much of the information needed for the road map.

  12. Research and Development. Annual Report 2000

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This report discusses the research and development activities in which NVE has been involved in 2000. These activities fall into three categories: watercourse research, hydrological research and energy related research. The HYDRA research programme, which studied flooding and human intervention, is discussed in particular. The report includes a list of research and development reports that were published in 2000.

  13. Canada Research Chairs | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    aspx. International Research Chairs Initiative. The International Research Chairs Initiative pairs top research talent from universities in Canada with their counterparts in developing countries to address key development challenges. View more

  14. Research Engagement for School Development

    Science.gov (United States)

    Wilkins, Raphael

    2011-01-01

    This thought-provoking book examines the new and growing phenomenon of the "research-engaged school"--schools that not only encourage their staff to carry out their own research, but also use published research to inform practice and improve the quality of education. The author draws upon his scholarship and practice in local authorities, schools…

  15. Research and development and industrial informatization

    International Nuclear Information System (INIS)

    1995-08-01

    This book deals with research and development and industrial informatization with development of technology international trend, the present conditions of scientific technology in the major nations, politics of technical development and trend, process of national research and development, research for industrial research and development, strengthen cooperation for scientific technology among nations, current situation and development of technology by field such as energy, software and system, and technology for industrial informatization.

  16. Historical Development of Origins Research

    Science.gov (United States)

    Lazcano, Antonio

    2010-01-01

    Following the publication of the Origin of Species in 1859, many naturalists adopted the idea that living organisms were the historical outcome of gradual transformation of lifeless matter. These views soon merged with the developments of biochemistry and cell biology and led to proposals in which the origin of protoplasm was equated with the origin of life. The heterotrophic origin of life proposed by Oparin and Haldane in the 1920s was part of this tradition, which Oparin enriched by transforming the discussion of the emergence of the first cells into a workable multidisciplinary research program. On the other hand, the scientific trend toward understanding biological phenomena at the molecular level led authors like Troland, Muller, and others to propose that single molecules or viruses represented primordial living systems. The contrast between these opposing views on the origin of life represents not only contrasting views of the nature of life itself, but also major ideological discussions that reached a surprising intensity in the years following Stanley Miller’s seminal result which showed the ease with which organic compounds of biochemical significance could be synthesized under putative primitive conditions. In fact, during the years following the Miller experiment, attempts to understand the origin of life were strongly influenced by research on DNA replication and protein biosynthesis, and, in socio-political terms, by the atmosphere created by Cold War tensions. The catalytic versatility of RNA molecules clearly merits a critical reappraisal of Muller’s viewpoint. However, the discovery of ribozymes does not imply that autocatalytic nucleic acid molecules ready to be used as primordial genes were floating in the primitive oceans, or that the RNA world emerged completely assembled from simple precursors present in the prebiotic soup. The evidence supporting the presence of a wide range of organic molecules on the primitive Earth, including membrane

  17. Web Developer | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Primary Duties or Responsibilities Web Development Leads all technical web ... design, and maintain the corporate website and any other internet properties IDRC ... and testing site for use by members of the website and social media team.

  18. Defense Nanotechnology Research and Development Program

    National Research Council Canada - National Science Library

    2007-01-01

    ...), Army Research Office (ARO) and the Air Force Office of Scientific Research (AFOSR)initiated numerous research and development programs focusing on advancing science and technology below one micron in size...

  19. Journal of Agricultural Research and Development

    African Journals Online (AJOL)

    The Journal of Agricultural Research and Development aims at publishing research reports, short communications, Critical Reviews in Agricultural Economics and Farm Management, Agronomy, Forestry, Animal Science, Food Technology, Soil Science, Home Economics, Agricultural Extension, Rural development, ...

  20. Publications | Page 11 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 101 - 110 of 6389 ... IDRC works with developing-country researchers and ... impact of our investment and advance development research. ... on a daily basis to her family in Huallhua, a tiny farming community in Peru's Andes Mountains.

  1. Estimations of On-site Directional Wave Spectra from Measured Ship Responses

    DEFF Research Database (Denmark)

    Nielsen, Ulrik Dam

    2006-01-01

    include an quivalence of energy in the governing equations and, as regards the parametric concept, a frequency dependent spreading of the waves is introduced. The paper includes an extensive analysis of full-scale measurements for which the directional wave spectra are estimated by the two ship response......In general, two main concepts can be applied to estimate the on-site directional wave spectrum on the basis of ship response measurements: 1) a parametric method which assumes the wave spectrum to be composed by parameterised wave spectra, or 2) a non-parametric method where the directional wave...

  2. Advanced research reactor fuel development

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chang Kyu; Pak, H. D.; Kim, K. H. [and others

    2000-05-01

    The fabrication technology of the U{sub 3}Si fuel dispersed in aluminum for the localization of HANARO driver fuel has been launches. The increase of production yield of LEU metal, the establishment of measurement method of homogeneity, and electron beam welding process were performed. Irradiation test under normal operation condition, had been carried out and any clues of the fuel assembly breakdown was not detected. The 2nd test fuel assembly has been irradiated at HANARO reactor since 17th June 1999. The quality assurance system has been re-established and the eddy current test technique has been developed. The irradiation test for U{sub 3}Si{sub 2} dispersed fuels at HANARO reactor has been carried out in order to compare the in-pile performance of between the two types of U{sub 3}Si{sub 2} fuels, prepared by both the atomization and comminution processes. KAERI has also conducted all safety-related works such as the design and the fabrication of irradiation rig, the analysis of irradiation behavior, thermal hydraulic characteristics, stress analysis for irradiation rig, and thermal analysis fuel plate, for the mini-plate prepared by international research cooperation being irradiated safely at HANARO. Pressure drop test, vibration test and endurance test were performed. The characterization on powders of U-(5.4 {approx} 10 wt%) Mo alloy depending on Mo content prepared by rotating disk centrifugal atomization process was carried out in order to investigate the phase stability of the atomized U-Mo alloy system. The {gamma}-U phase stability and the thermal compatibility of atomized U-16at.%Mo and U-14at.%Mo-2at.%X(: Ru, Os) dispersion fuel meats at an elevated temperature have been investigated. The volume increases of U-Mo compatibility specimens were almost the same as or smaller than those of U{sub 3}Si{sub 2}. However the atomized alloy fuel exhibited a better irradiation performance than the comminuted alloy. The RERTR-3 irradiation test of nano

  3. Ethiopian Journal of Development Research: Advanced Search

    African Journals Online (AJOL)

    PROMOTING ACCESS TO AFRICAN RESEARCH ... Ethiopian Journal of Development Research: Advanced Search ... containing either term; e.g., education OR research; Use parentheses to create more complex queries; ... Ethiopian Journal of Business and Economics (The), Ethiopian Journal of Development Research ...

  4. Institutional research and development, FY 1987

    Energy Technology Data Exchange (ETDEWEB)

    Struble, G.L.; Lawler, G.M.; Crawford, R.B.; Kirvel, R.D.; Peck, T.M.; Prono, J.K.; Strack, B.S. (eds.)

    1987-01-01

    The Institutional Research and Development program at Lawrence Livermore National Laboratory fosters exploratory work to advance science and technology, disciplinary research to develop innovative solutions to problems in various scientific fields, and long-term interdisciplinary research in support of defense and energy missions. This annual report describes research funded under this program for FY87. (DWL)

  5. Institutional research and development, FY 1987

    International Nuclear Information System (INIS)

    Struble, G.L.; Lawler, G.M.; Crawford, R.B.; Kirvel, R.D.; Peck, T.M.; Prono, J.K.; Strack, B.S.

    1987-01-01

    The Institutional Research and Development program at Lawrence Livermore National Laboratory fosters exploratory work to advance science and technology, disciplinary research to develop innovative solutions to problems in various scientific fields, and long-term interdisciplinary research in support of defense and energy missions. This annual report describes research funded under this program for FY87

  6. Research and development and management of technology

    International Nuclear Information System (INIS)

    Kim, Yeong Gil

    1989-04-01

    This book mentions current state of affairs on research and development and prospect : activity of business, field like information and materials, energy and resource, public welfare, general industry technology. It introduces policy on promotion of research and development such as propel of special research and development business, propel strategy for 10 priority tasks, reinforcement of basic research, promotion of information industry and propel for technical development of business.

  7. Ethiopian Journal of Development Research

    African Journals Online (AJOL)

    This research investigated whether non-farm income diversification increases overall income equality and decreases poverty in rural Ethiopia or not. It used a four-wave panel data from the Ethiopian Rural Household Survey over the period 1994-2009. The impacts of non-farm income on inequality and poverty were ...

  8. Materials Processing Research and Development

    Science.gov (United States)

    2010-08-01

    2 2.1.4 The Origins of Microstexture in Duplex Ti Alloys...Controlled Growth and Coarsening ....... 14 2.11 PUBLISHED RESEARCH ON FRICTION STIR WELDING OF SC-MODIFIED AL-ZN-MG-CU EXTRUDED PLATES...14 2.11.1 Friction Stir Welding of Sc

  9. Biosensing International Research and Development

    CERN Document Server

    Schultz, Jerome; Mrksich, Milan

    2006-01-01

    The goal of this book is to disseminate information on the worldwide status and trends in biosensing R&D to government decisionmakers and the research community. The contributors critically analyze and compare biosensing research in the United States with that being pursued in Japan, Europe and other major industrialized countries. Biosensing includes systems that incorporate a variety of means, including electrical, electronic, and photonic devices; biological materials (e.g., tissue, enzymes, nucleic acids, etc.); and chemical analysis to produce detectable signals for the monitoring or identification of biological phenomena. In a broader sense, the study of biosensing includes any approach to detection of biological elements and the associated software or computer identification technologies (e.g., imaging) that identify biological characteristics. Biosensing is finding a growing number of applications in a wide variety of areas, including biomedicine, food production and processing, and detection of b...

  10. Research reactor developments in Australia

    International Nuclear Information System (INIS)

    Godfrey, Robert

    1998-01-01

    The Australian Nuclear Science and Technology Organization (ANSTO) operates the 10 MW research reactor, HIFAR, at the Lucas Heights site approximately 30 kilometres south of Sydney. Although recent reviews and inspections have confirmed that HIFAR operates safely by an adequate margin and has minimal impact, it was concluded that the reactor design and age places limitations on its operation and utilization, and that HIFAR is approaching the end of its economic life. In September 1997, a decision was made by the Australian Government to found ANSTO for the construction of a replacement research on the existing Lucas Heights site, subject to the requisite environmental assessment process. A draft EIS has been prepared and is currently undergoing public review. A design specification is in preparation, and a research reactor vendor pre-qualification process has been initiated. Spent fuel shipments have been made to Dounreay and to the Savannah River Site, and discussions are continuing regarding the disposition of the existing spent fuel and that arising form HIFAR's remaining operation. (author)

  11. Crystallization and preliminary crystallographic studies of human septin 1 with site-directed mutations

    International Nuclear Information System (INIS)

    Hu, Hao; Yu, Wen-bo; Li, Shu-xing; Ding, Xiang-ming; Yu, Long; Bi, Ru-Chang

    2006-01-01

    The homogeneity of septin 1 has been improved by site-directed mutation of serine residues and only a small alteration in the secondary structure is observed to arise from the mutations. Crystals of the septin 1 mutant were grown and diffraction data were collected to 2.5 Å resolution. Septin 1 is a member of an evolutionarily conserved family of GTP-binding and filament-forming proteins named septins, which function in diverse processes including cytokinasis, vesicle trafficking, apoptosis, remodelling of the cytoskeleton, infection, neurodegeneration and neoplasia. Human septin 1 has been expressed and purified, but suffers from severe aggregation. Studies have shown that septin 1 with site-directed mutations of five serine residues (Ser19, Ser206, Ser307, Ser312 and Ser315) has a much lower degree of aggregation and better structural homogeneity and that the mutations cause only slight perturbations in the secondary structure of septin 1. This septin 1 mutant was crystallized and diffraction data were collected to 2.5 Å resolution. The space group is P422, with unit-cell parameters a = b = 106.028, c = 137.852 Å

  12. Crystallization and preliminary crystallographic studies of human septin 1 with site-directed mutations

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Hao [Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 (China); Yu, Wen-bo [State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433 (China); Li, Shu-xing [Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 (China); Ding, Xiang-ming; Yu, Long [State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433 (China); Bi, Ru-Chang [Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 (China)

    2006-02-01

    The homogeneity of septin 1 has been improved by site-directed mutation of serine residues and only a small alteration in the secondary structure is observed to arise from the mutations. Crystals of the septin 1 mutant were grown and diffraction data were collected to 2.5 Å resolution. Septin 1 is a member of an evolutionarily conserved family of GTP-binding and filament-forming proteins named septins, which function in diverse processes including cytokinasis, vesicle trafficking, apoptosis, remodelling of the cytoskeleton, infection, neurodegeneration and neoplasia. Human septin 1 has been expressed and purified, but suffers from severe aggregation. Studies have shown that septin 1 with site-directed mutations of five serine residues (Ser19, Ser206, Ser307, Ser312 and Ser315) has a much lower degree of aggregation and better structural homogeneity and that the mutations cause only slight perturbations in the secondary structure of septin 1. This septin 1 mutant was crystallized and diffraction data were collected to 2.5 Å resolution. The space group is P422, with unit-cell parameters a = b = 106.028, c = 137.852 Å.

  13. Improving the activity of the subtilisin nattokinase by site-directed mutagenesis and molecular dynamics simulation.

    Science.gov (United States)

    Weng, Meizhi; Deng, Xiongwei; Bao, Wei; Zhu, Li; Wu, Jieyuan; Cai, Yongjun; Jia, Yan; Zheng, Zhongliang; Zou, Guolin

    2015-09-25

    Nattokinase (NK), a bacterial serine protease from Bacillus subtilis var. natto, is a potential cardiovascular drug exhibiting strong fibrinolytic activity. To broaden its commercial and medical applications, we constructed a single-mutant (I31L) and two double-mutants (M222A/I31L and T220S/I31L) by site-directed mutagenesis. Active enzymes were expressed in Escherichia coli with periplasmic secretion and were purified to homogeneity. The kinetic parameters of enzymes were examined by spectroscopy assay and isothermal titration calorimetry (ITC), and their fibrinolytic activities were determined by fibrin plate method. The substitution of Leu(31) for Ile(31) resulted in about 2-fold enhancement of catalytic efficiency (Kcat/KM) compared with wild-type NK. The specific activities of both double-mutants (M222A/I31L and T220S/I31L) were significantly increased when compared with the single-mutants (M222A and T220S) and the oxidative stability of M222A/I31L mutant was enhanced with respect to wild-type NK. This study demonstrates the feasibility of improving activity of NK by site-directed mutagenesis and shows successful protein engineering cases to improve the activity of NK as a potent therapeutic agent. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Research and Development in ENSA

    International Nuclear Information System (INIS)

    2006-01-01

    We conceive R and D as a whole of creative works undertaken in a systematic way to increase our knowledge and conceive new applications for our productive processes. Advanced technology is developed and applied in ENSA by different departments. Coordination is done by the Technology Division. The development of new applications for the different metallurgical processes are mainly carried out by the Welding and Metallurgy Laboratories Development for process Automation and Robotization are carried out by the Automation department in close collaboration with the Welding, Engineering, Quality and Production departments, as appropriate. The upgrading of Machines and Installations is carried out by Engineering and Production. We believe in Innovation as an ongoing Strategy for our competitiveness. (Author)

  15. Site directed mutagenesis in Petunia using CRISPR/CAS9 technology

    NARCIS (Netherlands)

    Paulus den Hollander; Dr. Nelleke Kreike

    2013-01-01

    The Green Biotechnology research group focusses on the application of molecular breeding/biotechnological tools and also on the development/analysis of new tools, for the breeding of enhanced vegetable crops and ornamental plants. The research group is positioned within Inholland University of

  16. IDRC - International Development Research Centre |

    International Development Research Centre (IDRC) Digital Library (Canada)

    Learn moreArtificial intelligence and human development ... Our experts share insights on the issues and approaches challenging the international ... Shadow Libraries: Access to Knowledge in Global Higher Education · Book cover: ... Social Theories of Urban Violence in the Global South: Towards Safe and Inclusive Cities.

  17. 2010-11 Research Portfolio: Research & Development Division

    Science.gov (United States)

    Educational Testing Service, 2010

    2010-01-01

    This document describes the breadth of the research that the ETS (Educational Testing Service) Research & Development division is conducting in 2010. This portfolio will be updated in early 2011 to reflect changes to existing projects and new projects that were added after this document was completed. The research described in this portfolio falls…

  18. Energy storage research and development

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    In 2007, US consumers experienced the highest sustained gasoline prices in recent history, in real terms, including those seen in the early 1980s1. Partially as a result of the $3/gallon gasoline prices, sales of hybrid electric vehicles (HEVs) increased almost 60% in 20072, and several automakers announced plans to develop plug-in hybrid electric vehicles (PHEVs)3. However, total sales of HEVs remained in the 2-3 percent range of all vehicle sales. An important step for continued HEV market penetration, as well as electrifying the nation's personal transportation, is the development of cost effective, long lasting, and abuse tolerant Li-ion batteries.

  19. Research and Development from the bottom up

    DEFF Research Database (Denmark)

    Brem, Alexander; Wolfram, P.

    2014-01-01

    and ecological context or the growing interest of developed market firms in approaches from emerging markets. Hence, the presented framework supports further research in new paradigms for research and development (R&D) in developed market firms (DMFs), particularly in relation to emerging markets. This framework...... enables scholars to compare concepts from developed and emerging markets, to address studies specifically by using consistent terms, and to advance research into the concepts according their characterization....

  20. Reusable launch vehicle development research

    Science.gov (United States)

    1995-01-01

    NASA has generated a program approach for a SSTO reusable launch vehicle technology (RLV) development which includes a follow-on to the Ballistic Missile Defense Organization's (BMDO) successful DC-X program, the DC-XA (Advanced). Also, a separate sub-scale flight demonstrator, designated the X-33, will be built and flight tested along with numerous ground based technologies programs. For this to be a successful effort, a balance between technical, schedule, and budgetary risks must be attained. The adoption of BMDO's 'fast track' management practices will be a key element in the eventual success of NASA's effort.

  1. Nigerian Educational Research For Sustainable Development ...

    African Journals Online (AJOL)

    Education and research controls the development of any nation because no nation can rise above the products of its educational system. However, a number of problems face our educational and national development in general. The solution to such problem lies in research . educational research for sustainable ...

  2. Publications | Page 87 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 861 - 870 of 6381 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

  3. Publications | Page 17 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 161 - 170 of 6379 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

  4. Publications | Page 22 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 211 - 220 of 2177 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

  5. Participatory Research and Development for Sustainable Agriculture ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    It is crucial, for example, that local stakeholders provide input to the process. Participatory research and ... Participatory Research and Development for Sustainable Agriculture and Natural Resource Management - A Sourcebook Volume 2: Enabling Participatory Research and Development. Book cover Participatory ...

  6. Publications | Page 4 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 31 - 40 of 6375 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

  7. Publications | Page 31 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 301 - 310 of 6388 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

  8. Publications | Page 36 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 351 - 360 of 6341 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

  9. Publications | Page 29 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 281 - 290 of 6341 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

  10. Publications | Page 85 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 841 - 850 of 6381 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

  11. Publications | Page 82 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 811 - 820 of 6372 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

  12. Publications | Page 56 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 551 - 560 of 6381 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

  13. View all initiatives | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The International Research Chairs Initiative pairs top research talent from universities in Canada with their counterparts in developing countries to address key development challenges. We fund researchers driving global change. Careers · Contact Us · Subscribe · Unsubscribe · Site map. Follow us; Facebook · Twitter ...

  14. Publications | Page 22 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 211 - 220 of 6379 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

  15. Publications | Page 26 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 251 - 260 of 6378 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

  16. Publications | Page 79 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 781 - 790 of 6372 ... Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the results of our funded research, and offer free training materials to guide researchers and institutions. Want more? Explore outputs from more ...

  17. Research Skills Development in Higher Education Students

    Science.gov (United States)

    Bergamini, Tiziana Priede; Navarro, Cristina Lopez-Cozar

    2014-01-01

    This case study presents the development of a research project in a third-year undergraduate course, Family Business Administration. The research project aimed at promoting research skills in students. The authors formed working groups of no more than six students, and each group had to select an original research topic after conducting a…

  18. Research and Development Conference CIEE Program 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    CIEE`s second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director`s discretionary research, and exploratory research will also be featured in this report.

  19. Publications | Page 25 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 241 - 250 of 6341 ... Journal articles. Papers. Reports. Research in Action. Studies ... Half a year later, on. ... Over the past two decades, the International Development Research Centre (IDRC) has established and subsequently devolved ...

  20. Participatory Research and Development for Sustainable Agriculture ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Participatory research and development (PR&D) offers such an inclusive model. ... PR&D concepts and practices for practitioners, researchers, and academic. ... Call for new OWSD Fellowships for Early Career Women Scientists now open.

  1. Publications | Page 21 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 201 - 210 of 6387 ... Through books, articles, research publications, and studies, we aim to widen the ... Development Research Centre (IDRC), the project uses evidence to enhance the ... Greening South America, one business at a time.

  2. Research and Development Information System (RDIS)

    Data.gov (United States)

    Department of Veterans Affairs — The Research and Development Information System (RDIS) is the Veterans Affairs Central Office budgetary and project data repository for managing the VA Research and...

  3. Publications | Page 62 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 611 - 620 of 6341 ... IDRC works with developing-country researchers and institutions to build ... America, and Australia and to determine knowledge gaps for future research. ... health and rights framework for population and health policy, ...

  4. Journal of Agricultural Research and Development

    African Journals Online (AJOL)

    The Journal of Agricultural Research and Development aims at publishing research reports, short communications, Critical Reviews in Agricultural Economics and Farm ... Response of Sesamum radiatum Schum vegetable and seed yield to ...

  5. Research Award: Innovation for Inclusive Development program

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    2011-09-12

    Sep 12, 2011 ... students, as well as recent graduates, to enhance their research skills ... experience in development research. ... enable greater understanding of how innovation in the informal ... Innovation and women in the informal sector.

  6. IPMC microgripper research and development

    International Nuclear Information System (INIS)

    Lumia, R; Shahinpoor, M

    2008-01-01

    Described are the state of the art on designing and developing a microgripper using ionic polymer metal composites (IPMCs), an electroactive material, as an actuator to grasp and manipulate micro-sized flexible and rigid objects and yet also serve as a sensor for position feedback control. IPMCs, as a material, are compliant and can work in both wet and dry environments. This makes it ideally suited for both industrial operations, e.g., building microsystems from MEMS components, as well as for a variety of bio-micromanipulation tasks, e.g., bacterium and cell handling. We derive a theoretical force model for the microgripper. The model estimates that an IPMC finger of dimensions 5mm x lmm x 0.2mm exerts a force of 85 μN when grasping a solder ball of 15mg. We experimentally measure the load carrying capacity of the IPMC microgripper. Furthermore, we show empirically that the relationship between load carry capability and the length of microgripper fingers is linear. Experiments with three different microgripper finger shapes show that load carrying performance is related to the area of the finger rather than the shape. This implies that manufacturing ease favours microgrippers with tapered fingers. Finally, we show how flexible objects (hydrogel crystals in this case) are grasped with this IPMC microgripper.

  7. Agricultural extension, research, and development for increased ...

    African Journals Online (AJOL)

    The challenges of food security and agricultural development in South Africa cannot simply be solved by limiting extension and research development to the public sector. However, if shortcomings arise in the public sector while addressing extension, research and development, the potential involvement of the private sector ...

  8. Anindya Chatterjee | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Dr Anindya Chatterjee is Regional Director, Asia, based in New Delhi, India. He has provided leadership in research, research management, policy, and program development in the area of global health and development. Dr Chatterjee formerly worked internationally with United Nations development agencies, and ...

  9. Degeneration and domestication of a selfish gene in yeast: molecular evolution versus site-directed mutagenesis.

    Science.gov (United States)

    Koufopanou, Vassiliki; Burt, Austin

    2005-07-01

    VDE is a homing endonuclease gene in yeasts with an unusual evolutionary history including horizontal transmission, degeneration, and domestication into the mating-type switching locus HO. We investigate here the effects of these features on its molecular evolution. In addition, we correlate rates of evolution with results from site-directed mutagenesis studies. Functional elements have lower rates of evolution than degenerate ones and higher conservation at functionally important sites. However, functionally important and unimportant sites are equally likely to have been involved in the evolution of new function during the domestication of VDE into HO. The domestication event also indicates that VDE has been lost in some species and that VDE has been present in yeasts for more than 50 Myr.

  10. Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry.

    Science.gov (United States)

    Siverino, Claudia; Tabisz, Barbara; Lühmann, Tessa; Meinel, Lorenz; Müller, Thomas; Walles, Heike; Nickel, Joachim

    2018-03-29

    Different therapeutic strategies for the treatment of non-healing long bone defects have been intensively investigated. Currently used treatments present several limitations that have led to the use of biomaterials in combination with osteogenic growth factors, such as bone morphogenetic proteins (BMPs). Commonly used absorption or encapsulation methods require supra-physiological amounts of BMP2, typically resulting in a so-called initial burst release effect that provokes several severe adverse side effects. A possible strategy to overcome these problems would be to covalently couple the protein to the scaffold. Moreover, coupling should be performed in a site-specific manner in order to guarantee a reproducible product outcome. Therefore, we created a BMP2 variant, in which an artificial amino acid (propargyl-L-lysine) was introduced into the mature part of the BMP2 protein by codon usage expansion (BMP2-K3Plk). BMP2-K3Plk was coupled to functionalized beads through copper catalyzed azide-alkyne cycloaddition (CuAAC). The biological activity of the coupled BMP2-K3Plk was proven in vitro and the osteogenic activity of the BMP2-K3Plk-functionalized beads was proven in cell based assays. The functionalized beads in contact with C2C12 cells were able to induce alkaline phosphatase (ALP) expression in locally restricted proximity of the bead. Thus, by this technique, functionalized scaffolds can be produced that can trigger cell differentiation towards an osteogenic lineage. Additionally, lower BMP2 doses are sufficient due to the controlled orientation of site-directed coupled BMP2. With this method, BMPs are always exposed to their receptors on the cell surface in the appropriate orientation, which is not the case if the factors are coupled via non-site-directed coupling techniques. The product outcome is highly controllable and, thus, results in materials with homogeneous properties, improving their applicability for the repair of critical size bone defects.

  11. Development of a research evaluation protocol for NSD research portfolios

    International Nuclear Information System (INIS)

    Gould, J.

    1999-01-01

    This report is concerned with developing and describing a research evaluation protocol for use by the Nuclear Safety Directorate (NSD), in evaluating their various programmes of research; or aspects of those programmes. The Health and Safety Executive (HSE) has been involved with research evaluation for some considerable time and NSD, as part of HSE, wishes to develop a protocol which, while it meets their needs, is also fully compatible with other HSE approaches. It is intended that the methodology developed by this project will be used for evaluation of the Probabilistic Safety Assessment Portfolio (as a separate project). The usefulness of the methodology will be reviewed in the light of this experience

  12. Current research and development at the Nuclear Research Center Karlsruhe

    International Nuclear Information System (INIS)

    Kuesters, H.

    1982-01-01

    The Nuclear Research Center Karlsruhe (KfK) is funded to 90% by the Federal Republic of Germany and to 10% by the State of Baden-Wuerttemberg. Since its foundation in 1956 the main objective of the Center is research and development (R and D) in the aera of the nuclear technology and about 2/3 of the research capacity is now devoted to this field. Since 1960 a major activity of KfK is R and D work for the design of fast breeder reactors, including material research, physics, and safety investigations; a prototype of 300 MWe is under construction now in the lower Rhine Valley. For enrichment of 235 U fissile material KfK developed the separation nozzle process; its technical application is realized within an international contract between the Federal Republic of Germany and Brazil. Within the frame of the European Programme on fusion technology KfK develops and tests superconducting magnets for toroidal fusion systems; a smaller activity deals with research on inertial confinement fusion. A broad research programme is carried through for safety investigations of nuclear installations, especially for PWRs; this activity is supplemented by research and development in the field of nuclear materials' safeguards. Development of fast reactors has to initiate research for the reprocessing of spent fuel and waste disposal. In the pilot plant WAK spent fuel from LKWs is reprocessed; research especially tries e.g. to improve the PUREX-process by electrochemical means, vitrification of high active waste is another main activity. First studies are being performed now to clarify the necessary development for reprocessing fast reactor fuel. About 1/3 of the research capacity of KfK deals with fundamental research in nuclear physics, solid state physics, biology and studies on the impact of technology on environment. Promising new technologies as e.g. the replacement of gasoline by hydrogen cells as vehicle propulsion are investigated. (orig.)

  13. Mobility Research and Development (Briefing charts)

    Science.gov (United States)

    2016-03-17

    Mobility Research & Development Dr. Paramsothy Jayakumar, STE, Analytics Tank Automotive Research, Development and Engineering Center Research...Mobility Model (NRMM) • Dr. M. G. Bekker of TARDEC is the “Father of Terrain-Vehicle Systems ” • NRMM was developed in 1960-70 by TARDEC and ERDC...Blocks: Scaled Experiments Particle Image Velocimetry Pressure – Sinkage Test Direct Shear Test Simulations Single Wheel Test Plate width = 50 mm

  14. Cuba | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Researchers developed a way for community members to track mosquito ... government, and business, they bring concrete and innovative development ideas to ... areas such as maternal and child health, and sustainable water management.

  15. Next-generation site-directed transgenesis in the malaria vector mosquito Anopheles gambiae: self-docking strains expressing germline-specific phiC31 integrase.

    Directory of Open Access Journals (Sweden)

    Janet M Meredith

    Full Text Available Diseases transmitted by mosquitoes have a devastating impact on global health and the situation is complicated due to difficulties with both existing control measures and the impact of climate change. Genetically modified mosquitoes that are refractory to disease transmission are seen as having great potential in the delivery of novel control strategies. The Streptomyces phage phiC31 integrase system has been successfully adapted for site-directed transgene integration in a range of insects, thus overcoming many limitations due to size constraints and random integration associated with transposon-mediated transformation. Using this technology, we previously published the first site-directed transformation of Anopheles gambiae, the principal vector of human malaria. Mosquitoes were initially engineered to incorporate the phiC31 docking site at a defined genomic location. A second phase of genetic modification then achieved site-directed integration of an anti-malarial effector gene. In the current publication we report improved efficiency and utility of the phiC31 integrase system following the generation of Anopheles gambiae self-docking strains. Four independent strains, with docking sites at known locations on three different chromosome arms, were engineered to express integrase under control of the regulatory regions of the nanos gene from Anopheles gambiae. The resulting protein accumulates in the posterior oocyte to provide integrase activity at the site of germline development. Two self-docking strains, exhibiting significantly different levels of integrase expression, were assessed for site-directed transgene integration and found to demonstrate greatly improved survival and efficiency of transformation. In the fight against malaria, it is imperative to establish a broad repertoire of both anti-malarial effector genes and tissue-specific promoters to regulate their expression, enabling those offering maximum effect with minimum fitness

  16. Publications | Page 42 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 411 - 420 of 6382 ... Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the results of our funded ... Evaluation in the Extreme: Research, Impact and Politics in Violently Divided Societies. Over the past two decades, ...

  17. Publications | Page 76 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 751 - 760 of 6335 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research ... Caribbean health : diversity in local food production to combat obesity (restricted access). Led by researchers from McGill ...

  18. Gender | Page 230 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    For research results to improve people's lives, they must reach decision-makers who can use them to develop more effective policies and practices. About 20% of IDRC's project funding in the past year — and the past decade — went to research that aimed to influence policies. To help IDRC-supported research results ...

  19. Managing Research Libraries in Developing Economy | Ahmed ...

    African Journals Online (AJOL)

    This paper discusses managing research libraries in developing economy. The concepts of special libraries, funding of research libraries, the need for training and retraining of library staff and resources sharing networking were highlighted. The paper recommends that research Institutes need to re-order their priorities ...

  20. Research in Review. Malnutrition and Children's Development.

    Science.gov (United States)

    Stevens, Joseph H., Jr.; Baxter, Delia H.

    1981-01-01

    Indicates how various degrees of malnutrition affect children's development. Reviews research conducted in several developing countries and the United States, and describes the nutritional status of children in the United States. Implications for nutrition programs, research and policy formation are pointed out. (Author/RH)

  1. Program Leader | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Leads in the identification of the overall development research ... Ensures that a regional perspective is brought to bear on program planning at the PI and ... The incumbent is the manager of the Program Initiative program and team and as such: ... projects between Canadian and developing country researchers; and; When ...

  2. Publications | Page 50 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 491 - 500 of 6341 ... Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. ... ​Does the unequal distribution of technological resources and available data sets threaten the developing world's participation in the open data ...

  3. Research and Development Conference CIEE Program 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    CIEE's second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director's discretionary research, and exploratory research will also be featured in this report.

  4. New Product Development and Business Strategy of Research and Development

    International Nuclear Information System (INIS)

    Lee, Sun Cheol

    1998-05-01

    The contents of this book are new product development strategy of the top business, commercialization and new product development, development case analysis and framework of new product development, investigation strategy for idea of new product development, case analysis of research as development and goal of new product development, case analysis and planning and management for new product development, innovative item development and technical management against confusion, the map for determination procedure of development, strategy of market and goods and development strategy cases in leading company.

  5. Ion Channel Conformation and Oligomerization Assessment by Site-Directed Spin Labeling and Pulsed-EPR.

    Science.gov (United States)

    Pliotas, Christos

    2017-01-01

    Mechanosensitive (MS) ion channels are multimeric integral membrane proteins that respond to increased lipid bilayer tension by opening their nonselective pores to release solutes and relieve increased cytoplasmic pressure. These systems undergo major conformational changes during gating and the elucidation of their mechanism requires a deep understanding of the interplay between lipids and proteins. Lipids are responsible for transmitting lateral tension to MS channels and therefore play a key role in obtaining a molecular-detail model for mechanosensation. Site-directed spin labeling combined with electron paramagnetic resonance (EPR) spectroscopy is a powerful spectroscopic tool in the study of proteins. The main bottleneck for its use relates to challenges associated with successful isolation of the protein of interest, introduction of paramagnetic labels on desired sites, and access to specialized instrumentation and expertise. The design of sophisticated experiments, which combine a variety of existing EPR methodologies to address a diversity of specific questions, require knowledge of the limitations and strengths, characteristic of each particular EPR method. This chapter is using the MS ion channels as paradigms and focuses on the application of different EPR techniques to ion channels, in order to investigate oligomerization, conformation, and the effect of lipids on their regulation. The methodology we followed, from the initial strategic selection of mutants and sample preparation, including protein purification, spin labeling, reconstitution into lipid mimics to the complete set-up of the pulsed-EPR experiments, is described in detail. © 2017 Elsevier Inc. All rights reserved.

  6. Site-directed mutation of a laccase from Thermus thermophilus: Effect on the activity profile

    Directory of Open Access Journals (Sweden)

    Liu Xin

    2012-01-01

    Full Text Available A site-directed mutant R453T of a laccase from Thermus thermophilus HB27 (Tth-laccase was constructed in order to investigate the effect on laccase catalytic properties. The mutated gene was cloned and overexpressed in Escherichia coli. Nickel-affinity purification was achieved and followed by copper ion incorporation. The mature mutated enzyme was quantitatively equal to the wild type. A photometric assay based on the oxidation of the substrate 2,2-azino-bis-(3- ethylbenzthiazoline-6-sulfonate (ABTS was employed in comparison with the wild-type Tth-laccase on catalytic properties. The R453T mutant exhibited improvement in substrate affinity and specific activity at room temperature, whereas those parameters were not significantly influenced when the temperature increased up to 65°C or higher. The mutant had better catalytic activity than that of the wild type at acidic pH. Investigated by circular dichroism spectroscopy, the mutant Tth-laccase displayed similar profiles at low and high temperatures.

  7. Specificity of N-terminal methionyl peptidase: analysis by site-directed mutagenesis

    International Nuclear Information System (INIS)

    Kasper, T.J.; Boissel, J.P.; Bunn, H.F.

    1987-01-01

    The start site of eukaryotic translation is normally an AUG codon. The corresponding N-terminal methionine is most often removed when the nascent chain reaches about 30 residues. Data from a survey of 1764 eukaryotic protein sequences suggest that the residue adjacent to the initiator Met determines Met cleavage. In order to investigate the mechanism of this reaction, the authors have prepared oligonucleotide-directed mutants of human β-globin from gapped heteroduplexes of a T3/T7 plasmid containing a globin cDNA clone. To date, the authors have produced mutants encoding for 15 of 19 possible amino acid replacements at position 1 in the β-globin chain. These mutants have been confirmed by dideoxy sequencing, transcribed in vitro, and translated in a rabbit reticulocyte lysate in the presence of 35 S-methionine. Labeled translation products were then isolated by cation exchange HPLC, and tryptic peptides were analyzed by RP-HPLC. Thus far, this structural analysis has shown that for β-1 Val, Ala, and Ser, the initiator Met is cleaved, whereas for β-1 Lys, Met, Glu, Trp, Asn, Tyr, and Glu, initiator Met is retained. For β-1 Leu initiator Met is cleaved with a frequency of about 50%. These results are consistent with the data obtained from the previous survey. The expression of site-directed mutants in a cell-free system can also be used to investigate other N-terminal processing events, such as acetylation and myristylation

  8. Improving the neutral phytase activity from Bacillus amyloliquefaciens DSM 1061 by site-directed mutagenesis.

    Science.gov (United States)

    Xu, Wei; Shao, Rong; Wang, Zupeng; Yan, Xiuhua

    2015-03-01

    Neutral phytase is used as a feed additive for degradation of anti-nutritional phytate in aquatic feed industry. Site-directed mutagenesis of Bacillus amyloliquefaciens DSM 1061 phytase was performed with an aim to increase its activity. Mutation residues were chosen based on multiple sequence alignments and structure analysis of neutral phytsaes from different microorganisms. The mutation sites on surface (D148E, S197E and N156E) and around the active site (D52E) of phytase were selected. Analysis of the phytase variants showed that the specific activities of mutants D148E and S197E remarkably increased by about 35 and 13% over a temperature range of 40-75 °C at pH 7.0, respectively. The k cat of mutants D148E and S197E were 1.50 and 1.25 times than that of the wild-type phytase, respectively. Both D148E and S197E showed much higher thermostability than that of the wild-type phytase. However, mutants N156E and D52E led to significant loss of specific activity of the enzyme. Structural analysis revealed that these mutations may affect conformation of the active site of phytase. The present mutant phytases D148E and S197E with increased activities and thermostabilities have application potential as additives in aquaculture feed.

  9. Peter Taylor | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    He leads a multidisciplinary team that strengthens policy research capacity in developing countries on issues of economic policy, governance, and health systems. Peter has more than 30 years of experience in international development, including positions at the Institute of Development Studies, UK; Helvetas Vietnam; ...

  10. View all initiatives | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Open Data for Development program's global network will facilitate and scale innovative approaches to open data to ensure benefits reach citizens in developing countries. Combining research and action to address scaling and sustainability of open data for development initiatives is key to the network's success.

  11. Software Development as Music Education Research

    Science.gov (United States)

    Brown, Andrew R.

    2007-01-01

    This paper discusses how software development can be used as a method for music education research. It explains how software development can externalize ideas, stimulate action and reflection, and provide evidence to support the educative value of new software-based experiences. Parallels between the interactive software development process and…

  12. Identification of residues involved in nucleotidyltransferase activity of JHP933 from helicobacter pyloriby site-directed mutagenesis

    Directory of Open Access Journals (Sweden)

    Ye Xianren

    2016-01-01

    Full Text Available Helicobacter pylori is a well-known bacterial pathogen involved in the development of peptic ulcer, gastric adenocarcinoma and other forms of gastric cancer. Evidence has suggested that certain strain-specific genes in the plasticity region may play key roles in the pathogenesis of H. pylori-associated gastroduodenal diseases. Therefore there is considerable interest in the strain-specific genes located in the plasticity regions of H. pylori. JHP933 is encoded by the gene in the plasticity region of H. pylori strain J99. Recently, the crystal structure of JHP933 has confirmed it as a nucleotidyltransferase (NTase superfamily protein and a putative active site has been proposed. However, no evidence from direct functional assay has been presented to confirm the active site and little is known about the functional mechanism of JHP933. Here, through superimposition with Cid1/NTP complex structures, we modelled the complex structures of JHP933 with different NTPs. Based on the models and using rational site-directed mutagenesis combined with enzymatic activity assays, we confirm the active site and identify several residues important for the nucleotidyl transferring function of JHP933. Furthermore, mutations of these active site residues result in the abolishment of the nucleotidyltransferase activity of JHP933. This work provides preliminary insight into the molecular mechanism underlying the pathophysiological role in H. pylori infection of JHP933 as a novel NTase superfamily protein.

  13. A saxitoxin-binding aptamer with higher affinity and inhibitory activity optimized by rational site-directed mutagenesis and truncation.

    Science.gov (United States)

    Zheng, X; Hu, B; Gao, S X; Liu, D J; Sun, M J; Jiao, B H; Wang, L H

    2015-07-01

    Saxitoxin (STX), a member of the family of paralytic shellfish poisoning toxins, poses toxicological and ecotoxicological risks. To develop an analytical recognition element for STX, a DNA aptamer (APT(STX1)) was previously discovered via an iterative process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) by Handy et al. Our study focused on generating an improved aptamer based on APT(STX1) through rational site-directed mutation and truncation. In this study, we generated the aptamer, M-30f, with a 30-fold higher affinity for STX compared with APT(STX1). The Kd value for M-30f was 133 nM, which was calculated by Bio-Layer Interferometry. After optimization, we detected and compared the interaction of STX with aptamers (APT(STX1) or M-30f) through several techniques (ELISA, cell bioassay, and mouse bioassay). Both aptamers' STX-binding ability was demonstrated in all three methods. Moreover, M-30f performs better than its parent sequence with higher suppressive activity against STX. As a molecular recognition element, M-30f has good prospects for practical application. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. SimLabel: a graphical user interface to simulate continuous wave EPR spectra from site-directed spin labeling experiments.

    Science.gov (United States)

    Etienne, E; Le Breton, N; Martinho, M; Mileo, E; Belle, V

    2017-08-01

    Site-directed spin labeling (SDSL) combined with continuous wave electron paramagnetic resonance (cw EPR) spectroscopy is a powerful technique to reveal, at the residue level, structural transitions in proteins. SDSL-EPR is based on the selective grafting of a paramagnetic label on the protein under study, followed by cw EPR analysis. To extract valuable quantitative information from SDSL-EPR spectra and thus give reliable interpretation on biological system dynamics, numerical simulations of the spectra are required. Such spectral simulations can be carried out by coding in MATLAB using functions from the EasySpin toolbox. For non-expert users of MATLAB, this could be a complex task or even impede the use of such simulation tool. We developed a graphical user interface called SimLabel dedicated to run cw EPR spectra simulations particularly coming from SDSL-EPR experiments. Simlabel provides an intuitive way to visualize, simulate, and fit such cw EPR spectra. An example of SDSL-EPR spectra simulation concerning the study of an intrinsically disordered region undergoing a local induced folding is described and discussed. We believe that this new tool will help the users to rapidly obtain reliable simulated spectra and hence facilitate the interpretation of their results. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  15. Research and Development Costs in Retail Trade

    Directory of Open Access Journals (Sweden)

    Radojko LUKIC

    2016-12-01

    Full Text Available Research and development expenses are crucial business performance factors for all enterprises, including trading companies. The size and structure of these expenses depend largely on the nature of a company’s activities. Due to such importance and specificity, the research focus of this article is on R&D expenses in trading companies with particular emphasis on retail companies. Their share in the sales revenue of trading companies is increasingly important and determined by many factors, such as innovation, size, location, product categories, and others. Due to varying intensity of influence of these and other factors, research and development expenses in commercial companies differ among countries, trade types (wholesale, retail, wholesale and retail, retail formats (store types and product categories. Understanding the factors of these differences is important for efficient management of research and development costs in trade, particularly retail companies. They are the focus of research in this work.

  16. Laos | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    As a result, local university researchers studied the effects of a new protected forest ... city of Luang Prabang, which introduced Internet services to rural people. ... the Government of Laos improve trade negotiations; leaders develop sound ...

  17. Publications | Page 75 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 741 - 750 of 6346 ... IDRC works with developing-country researchers and institutions to ... Improving the Nutrition and Health of CARICOM Populations : final ... policy and an unfavorable legal and regulatory environment, which in turn ...

  18. Publications | Page 28 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 271 - 280 of 6341 ... IDRC works with developing-country researchers and ... food and nutrition security for low- and middle-income households in Kenya and Uganda. ... of the work IDRC's Rural Poverty and Environment program has ...

  19. Gender | Page 229 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    . ... Building Businesses with Small Producers présente les constatations et une analyse ... Researchers identified the regions in Southeast Asia most vulnerable to ... asked why some children in developing countries are not being vaccinated.

  20. Guatemala | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Our early work in Guatemala targeted farming efficiency, access to water, ... Researchers also developed a low-cost coffee drying machine powered by coffee ... National Campaign for Inter-ethnic Dialogue, a public education campaign that ...

  1. Publications | Page 6 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 51 - 60 of 7327 ... IDRC works with developing-country researchers and institutions to build local ... Mobile phones, Internet, and gender in Myanmar ... India believe music can offer clues about the ability of the brain to transfer learning.

  2. Problems of scientific research in developing countries

    International Nuclear Information System (INIS)

    Vose, P.B.; Cervellini, A.

    1983-01-01

    The paper gives a general consideration of the problems encountered in the scientific research by the developing countries. Possible optimizations in the long term as well as short term strategies are pointed out

  3. Bolivia | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... systems, mining policies, natural resource management, labour force development, waste management, and land use reforms. ... Total IDRC Support ... stimulate high-quality, policy-relevant research by Bolivians; test climate change ...

  4. Publications | Page 9 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 81 - 90 of 6389 ... Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development ... Journal articles ... Forging a brighter future for Haiti through higher education.

  5. Agricultural biotechnology research and development in Ethiopia

    African Journals Online (AJOL)

    PRECIOUS

    2009-12-29

    Dec 29, 2009 ... Review. Agricultural biotechnology research and development in Ethiopia ... seed micropropagation, virus-cleaning ongoing, good progress. Garlic meristem ... large quantities of disease-free planting materials in short time.

  6. Cambodia | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... the National Information Communications Technology Development Authority. ... The research helped people improve their livelihoods, set limits on resource use, ... A national non-governmental organization called The Learning Institute, ...

  7. Thailand | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    In 1994, we helped create the Asian Development Research Forum, based at the ... topics as pensions, health care, migration, and women's role in family care. ... improve flood management planning to counteract climate change disasters, ...

  8. President | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    International Development Research Centre Selection Criteria Education A ... or an acceptable combination of education, job-related training and/or experience. ... Knowledge of current corporate governance and human resource issues; ...

  9. IDRC Research Awards 2019 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Citizens of developing countries pursuing a master's or a doctoral degree at a ... and will receive hands-on experience in research and program management and ... dissemination, and use of knowledge from an international perspective.

  10. Gender | Page 208 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC's mission is to support developing-country scientists in conducting applied, community-based research on ... Improve resource management, improve human health ... A new perspective on the links between health and ecosystems.

  11. View all initiatives | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The International Partnerships for Sustainable Societies are collaborations that produce high-quality research to inform academic, public, and policy debates to contribute to create just, inclusive, and sustainable social and economic development.

  12. Vital statistics | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-07-13

    Jul 13, 2011 ... Population and Health in Developing Countries: Vol 1. ... We track down all those movements," says Dr Pierre Ngom, a senior research ... was recognized for its efforts to improve health service provision and the monitoring of ...

  13. David M. Malone President, International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    malonedm

    independent research and policy development institution in New York. From 1994 to 1998 ... His widely reviewed book The International Struggle Over Iraq: Politics in the ... also to write in a lighter vein, often for the Literary Review of Canada.

  14. Magnetic fusion research in developing countries

    International Nuclear Information System (INIS)

    Hassan, M.H.A.

    1990-01-01

    This article is a presentation prepared by the Third World Academy of Sciences on magnetic fusion research activity in the developing countries and its connection with the IAEA's own fusion programme. 6 figs, 1 tab

  15. Center for Cold Spray Research and Development

    Data.gov (United States)

    Federal Laboratory Consortium — This is the only DoD facility capable of cold spray research and development, production, and field-repair. It features three stationary cold spray systems used for...

  16. Publications | Page 62 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 611 - 620 of 6389 ... IDRC works with developing-country researchers and institutions to ... sp. strain UCD-UG_FMILLET was isolated from the roots of the Afro-. ... and men that perpetuate gender and inequality and power imbalances.

  17. Bulletin #111 | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Turning value chains into social gains in SE Asia: IDRC starts new work in ASEAN ... and promote youth development by enhancing community-based social capital. ... BUILDING AND EVALUATING RESEARCH CAPACITY IN HEALTHCARE ...

  18. Federal Support for Research and Development

    National Research Council Canada - National Science Library

    Campbell, Sheila

    2007-01-01

    ...-being. Private businesses are the largest sponsors of research and development (R&D) in the United States, producing the discoveries that in turn lead to new products and services and the growth of productivity...

  19. Using Architectures for Research, Development, and Acquisition

    National Research Council Canada - National Science Library

    Dickerson, C

    2004-01-01

    The goal of this book is to show how architectures can be used to enable a capabilities-based approach to the research, development, and acquisition of DoD families of systems that must interoperate...

  20. Publications | Page 56 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 551 - 560 of 6372 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, ... The private sector, non-governmental organisations, government... Fisheries, aquaculture and living well in ...

  1. Publications | Page 39 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 381 - 390 of 6341 ... IDRC works with developing-country researchers and ... Through books, articles, research publications, and studies, we aim to ... Fish Farmers' Utilization of Social Networks in Adapting to ... City profile : Guwahati (restricted access) ... Nigeria : a case study of the Amnesty Programme (open access).

  2. Research and professional development of teacher educators

    NARCIS (Netherlands)

    Lunenberg, Mieke; Willemse, Martijn

    2006-01-01

    Over the last decade teacher educators have started to systematically study the processes involved in their efforts to improve their teacher education practices. This research by teacher educators (self-study research) has made an enormous contribution to the professional development of the teacher

  3. Global Affairs Canada | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    For example, Vietnamese and Canadian research teams developed micronutrient-enriched instant flours and baby cereals using local crops and local processing facilities. Global Affairs Canada, IDRC, and the Canadian Institutes of Health Research are collaborating to improve health outcomes for African mothers and ...

  4. Development research in South Africa | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-01-11

    Jan 11, 2011 ... IDRC Communications ... It would result, some three years later, in a program of development research support designed expressly to prepare ... In South Africa, post-secondary education is a privilege, and many students currently enrol ... Recent research into decision-making in households has produced ...

  5. The AECL research and development program

    International Nuclear Information System (INIS)

    Hart, R.G.; Woods, A.D.B.

    1980-02-01

    The research and development program of the Atomic Energy of Canada Research Company is briefly described. Goals and objectives are emphasized, some recent highlights are given and the importance of technology transfer is discussed. A short representative bibliography is included. (auth)

  6. Publications | Page 14 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 131 - 140 of 6379 ... This series of case studies emerged from an action-research project entitled Developing Evaluation and Communication Capacity in Information Society Research (DECI-2). The predecessor DECI-1 project focused only on evaluation mentoring in Asia. The subsequent DECI-2 project collaborated ...

  7. Publications | Page 79 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 781 - 790 of 6341 ... We share the results of our funded research, and offer free ... Through books, articles, research publications, and studies, we aim to widen the impact of ... Tourism is an important driver of economic growth throughout Southeast Asia. Inclusive development in health and education in the GMS : the ...

  8. View all initiatives | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Science Granting Councils Initiative in Sub-Saharan Africa is focused on strengthening the capacities of science granting councils in order to support research and evidence-based policies that will contribute to economic and social development in Sub-Saharan Africa. We fund researchers driving global change.

  9. Present status of HTGR research and development

    International Nuclear Information System (INIS)

    1992-08-01

    This report briefly describes the progress of the construction of the High Temperature Engineering Test Reactor (HTTR), Research and Development (R and D) on the advanced technologies for the High Temperature Gas-cooled Reactors (HTGRs) and international cooperation in the Japan Atomic Energy Research Institute (JAERI) in 1991. (J.P.N.)

  10. Developing Research Skills across the Undergraduate Curriculum

    Science.gov (United States)

    Gray, Simon; Coates, Lee; Fraser, Ann; Pierce, Pam

    2015-01-01

    This chapter describes consortial efforts within the Great Lakes Colleges Association to share expertise and programming to build research skills throughout the undergraduate curriculum. Strategies to scaffold research skill development are provided from Allegheny College, Kalamazoo College, and The College of Wooster.

  11. Cambodia Development Research Forum II | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cambodia's research community is still rebuilding from decades of turmoil that included civil war and a period of ethnic and intellectual cleansing under the Khmer Rouge. Its development research community remains dispersed and unconnected, though there are pockets of strong capacity. IDRC was one of the first ...

  12. Agricultural biotechnology research and development in Ethiopia ...

    African Journals Online (AJOL)

    Ethiopia is an agrarian country that can have enormous benefit from the applications of biotechnology for increasing its agricultural productivity. The country is at initial stages of research and development in agricultural biotechnology with scattered efforts underway in various public institutions. Research efforts and ...

  13. Publications | Page 86 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 851 - 860 of 6372 ... Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. ... Global pathways to men's caregiving: mixed methods findings from the international men and gender equality survey and the men who care study ...

  14. Publications | Page 8 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 71 - 80 of 6341 ... Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. ... Brazil, metal waste and mud flowed downstream, contaminating the water and wreaking havoc as the worst environmental disaster in the nation's history.

  15. Nepal | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Plant breeding research in the 1980s and 1990s led to more productive cereals, such as finger millet and barley. Other efforts have strengthened farmers' ability to conserve the genetic diversity of their traditional crops. An improved rice variety — developed collaboratively by farmers and researchers — was introduced in ...

  16. Gender | Page 227 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Language English ... In a 12-country study, researchers asked why some children in developing countries are not being vaccinated. ... About 20% of IDRC's project funding in the past year — and the past decade — went to research that aimed ...

  17. Canada | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    While working with some of the brightest minds in Canada and the world, we've found that knowledge-sharing through networks and regions helps widen the impact of the research we fund. It is through the interaction of ideas, people, and money in worldwide development research and policy that we put our principles into ...

  18. US Army Medical Research and Development Report.

    Science.gov (United States)

    1979-10-01

    RI) US ARMY MEDICAL RESEARCH AND DEVELOPMENT REPORT. Colonel/John Jr DTIC JUL 1 5 1980; A USL &MY MEDICAL BIOENGINEERING RESEARCH AND DEVELOPMENT...pollutants in water or soil . Pollutant by-products and breakdown products in water, air or soil will be isolated, characterized, and quantified. Where...determination of selected low-level pollutants io soil and water. Degradation products and secondary pollutants arising from munitions manufacture or pest

  19. Is Mixed Methods Research Used in Australian Career Development Research?

    Science.gov (United States)

    Cameron, Roslyn

    2010-01-01

    Mixed methods research has become a substantive and growing methodological force that is growing in popularity within the human and social sciences. This article reports the findings of a study that has systematically reviewed articles from the "Australian Journal of Career Development" from 2004 to 2009. The aim of the study was to…

  20. Enhancing activity and thermostability of lipase A from Serratia marcescens by site-directed mutagenesis.

    Science.gov (United States)

    Mohammadi, Mohsen; Sepehrizadeh, Zargham; Ebrahim-Habibi, Azadeh; Shahverdi, Ahmad Reza; Faramarzi, Mohammad Ali; Setayesh, Neda

    2016-11-01

    Lipases as significant biocatalysts had been widely employed to catalyze various chemical reactions such as ester hydrolysis, ester synthesis, and transesterification. Improving the activity and thermostability of enzymes is desirable for industrial applications. The lipase of Serratia marcescens belonging to family I.3 lipase has a very important pharmaceutical application in production of chiral precursors. In the present study, to achieve improved lipase activity and thermostability, using computational predictions of protein, four mutant lipases of SML (MutG2P, MutG59P, Mut H279K and MutL613WA614P) were constructed by site-directed mutagenesis. The recombinant mutant proteins were over-expressed in E. coli and purified by affinity chromatography on the Ni-NTA system. Circular dichroism spectroscopy, differential scanning calorimetry and kinetic parameters (Km and kcat) were determined. Our results have shown that the secondary structure of all lipases was approximately similar to one another. The MutG2P and MutG59P were more stable than wild type by approximately 2.3 and 2.9 in T 1/2 , respectively. The catalytic efficiency (kcat/Km) of MutH279K was enhanced by 2-fold as compared with the wild type (p<0.05). These results indicate that using protein modeling program and creating mutation, can enhance lipase activity and/or thermostability of SML and it also could be used for improving other properties of enzyme to the desired requirements as well as further mutations. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Cloning, Site-Directed Mutagenesis, and Functional Analysis of Active Residues in Lymantria dispar Chitinase.

    Science.gov (United States)

    Fan, Xiao-Jun; Yang, Chun; Zhang, Chang; Ren, Hui; Zhang, Jian-Dong

    2018-01-01

    Chitinases are glycosyl hydrolases that catalyze the hydrolysis of β-(1,4)-glycosidic bonds in chitin, the major structural polysaccharide presented in the cuticle and gut peritrophic matrix of insects. Two aspartate residues (D143, D145) and one tryptophan (W146) in the Lymantria dispar chitinase are highly conserved residues observed within the second conserved motif of the family 18 chitinase catalytic region. In this study, a chitinase cDNA, LdCht5, was cloned from L. dispar, and the roles of the three residues were investigated using site-directed mutagenesis and substituting them with three other amino acids. Seven mutant proteins, D143E, D145E, W146G, D143E/D145E, D143E/W146G, D145E/W146G, and D143E/D145E/W146G, as well as the wild-type enzyme, were produced using the baculovirus-insect cell line expression system. The enzymatic and kinetic properties of these mutant enzymes were measured using the oligosaccharide substrate MU-(GlcNAc) 3 . Among the seven mutants, the D145E, D143E/D145E, and D145E/W146G mutations kept some extant catalytic activity toward MU-(GlcNAc) 3 , while the D143E, W146G, D143E/W146G, and D143E/D145E/W146G mutant enzymes were inactivated. Compared with the mutant enzymes, the wild-type enzyme had higher values of k cat and k cat / K m . A study of the multiple point mutations in the second conserved catalytic region would help to elucidate the role of the critical residues and their relationships.

  2. Site directed spin labeling studies of Escherichia coli dihydroorotate dehydrogenase N-terminal extension

    Energy Technology Data Exchange (ETDEWEB)

    Couto, Sheila G. [Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Av. Trabalhador Sao-carlense 400, C.P. 369, 13560-970, Sao Carlos, SP (Brazil); Grupo de Biofisica e Fisica Aplicada a Medicina, Instituto de Fisica, Universidade Federal de Goias, Campus Samambaia, C.P. 131, 74001-970, Goiania, GO (Brazil); Cristina Nonato, M. [Laboratorio de Cristalografia de Proteinas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av. do Cafe S/N, 14040-903, Ribeirao Preto, SP (Brazil); Costa-Filho, Antonio J., E-mail: ajcosta@ffclrp.usp.br [Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Av. Trabalhador Sao-carlense 400, C.P. 369, 13560-970, Sao Carlos, SP (Brazil); Departamento de Fisica, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Av. Bandeirantes 3900, 14040-901, Ribeirao Preto, SP (Brazil)

    2011-10-28

    Highlights: Black-Right-Pointing-Pointer EcDHODH is a membrane-associated enzyme and a promising target for drug design. Black-Right-Pointing-Pointer Enzyme's N-terminal extension is responsible for membrane association. Black-Right-Pointing-Pointer N-terminal works as a molecular lid regulating access to the protein interior. -- Abstract: Dihydroorotate dehydrogenases (DHODHs) are enzymes that catalyze the fourth step of the de novo synthesis of pyrimidine nucleotides. In this reaction, DHODH converts dihydroorotate to orotate, using a flavine mononucleotide as a cofactor. Since the synthesis of nucleotides has different pathways in mammals as compared to parasites, DHODH has gained much attention as a promising target for drug design. Escherichia coli DHODH (EcDHODH) is a family 2 DHODH that interacts with cell membranes in order to promote catalysis. The membrane association is supposedly made via an extension found in the enzyme's N-terminal. In the present work, we used site directed spin labeling (SDSL) to specifically place a magnetic probe at positions 2, 5, 19, and 21 within the N-terminal and thus monitor, by using Electron Spin Resonance (ESR), dynamics and structural changes in this region in the presence of a membrane model system. Overall, our ESR spectra show that the N-terminal indeed binds to membranes and that it experiences a somewhat high flexibility that could be related to the role of this region as a molecular lid controlling the entrance of the enzyme's active site and thus allowing the enzyme to give access to quinones that are dispersed in the membrane and that are necessary for the catalysis.

  3. Research in Medicine: Essentials for Developing Countries

    Directory of Open Access Journals (Sweden)

    Yusuf YAKUPOGULLARI

    2014-06-01

    Full Text Available (ExtractThe well-being has been the highest topic for humanity throughout the adventure of mankind on the earth. Therefore, extensive efforts have been performed on the science of medicine, and glorious advances have been gained especially in the last two centuries. Research is essential for medicine to develop new therapeutic methods and to monitor the results of the current treatment given to the patient. These are possibly the simplest reasons for investigations in medicine. On the other hand, qualified human resource, research ethics, financial supports, regular data recording and analysis, and publication are important issues for improvement of the medical researches in the developing countries.... 

  4. Fostering Collaborations towards Integrative Research Development

    Directory of Open Access Journals (Sweden)

    Leonie Valentine

    2013-05-01

    Full Text Available The complex problems associated with global change processes calls for close collaboration between science disciplines to create new, integrated knowledge. In the wake of global change processes, forests and other natural environments have been rapidly changing, highlighting the need for collaboration and integrative research development. Few tools are available to explore the potential for collaborations in research ventures that are just starting up. This study presents a useful approach for exploring and fostering collaborations between academics working in research teams and organizations comprising multiple science disciplines (i.e., multi-disciplinary. The research aim was to reveal potential barriers, common ground, and research strengths between academics working in a new centre focused on forest and climate change research. This aim was based on the premise that raising awareness and working with this acquired knowledge fosters collaborations and integrative research development. An email survey was deployed amongst the academics to obtain: (i their understanding of common themes (e.g., climate change, scale of investigation, woodland/forest health/decline; (ii descriptions of the spatial and temporal scales of their research; and (iii their approach and perceived contributions to climate change research. These data were analysed using a semi-quantitative content analysis approach. We found that the main potential barriers were likely to be related to differences in understanding of the common research themes, whilst similarities and disciplinary strengths provided critical elements to foster collaborations. These findings were presented and discussed amongst the centre academics to raise awareness and create a dialogue around these issues. This process resulted in the development of four additional research projects involving multiple disciplines. The approach used in this study provides a useful methodology of broader benefit to

  5. Laboratory Directed Research ampersand Development Program

    International Nuclear Information System (INIS)

    Ogeka, G.J.; Romano, A.J.

    1993-12-01

    At Brookhaven National Laboratory the Laboratory Directed Research and Development (LDRD) Program is a discretionary research and development tool critical in maintaining the scientific excellence and vitality of the laboratory. It is also a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor in achieving and maintaining staff excellence, and a means to address national needs, within the overall mission of the Department of Energy and Brookhaven National Laboratory. This report summarizes research which was funded by this program during fiscal year 1993. The research fell in a number of broad technical and scientific categories: new directions for energy technologies; global change; radiation therapies and imaging; genetic studies; new directions for the development and utilization of BNL facilities; miscellaneous projects. Two million dollars in funding supported 28 projects which were spread throughout all BNL scientific departments

  6. Participatory Research and Development for Sustainable Agriculture ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Global experiences now show that the changing agenda requires new ways of thinking about and doing research and development. .... the sourcebook, review of paper contributions and participation in critical advisory committee meetings. ...... Creative methodologies are necessary in developing appropriate technologies ...

  7. Gender | Page 227 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Two years ago, the International Development Research Centre created CIME, a development communication program that reflects the interrelations between Communication at the grassroots level, the exchange of Information, two-way Media, and nonformal Education. This book presents the conceptual framework that led ...

  8. Second Language Writing Development: A Research Agenda

    Science.gov (United States)

    Polio, Charlene

    2017-01-01

    In 1998, Wolfe-Quintero, Inagaki & Kim published a monograph describing measures used in assessing writing development. Despite more recent research on linguistic development (e.g., Bulté & Housen 2012; Verspoor, Schmid & Xu 2012; Connor-Linton & Polio 2014), the volume is still a valuable resource and good starting point for…

  9. Applied research and development private sector accomplishments

    International Nuclear Information System (INIS)

    Beskid, N.J.; Devgun, J.S.; Erickson, M.D.; Zielke, M.M.

    1992-01-01

    This report describes the fiscal year 1990 procurement of contracts with the private sector and the current status of applied research and development conducted for DOE's Office of Technology Development (OTD). This report documents the procurement actions, discusses lessons learned from this activity, and disseminates the results of the procurement to interested parties in DOE and in the private sector

  10. Economics | Page 9 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    With a focus on developing countries, this book presents novel comparative research spanning three continents. The result is a more universal and dynamic view of the shaping and reshaping of interactions between firms and universities within different countries at various stages of development. Read more about ...

  11. Economics | Page 8 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    With a focus on developing countries, this book presents novel comparative research spanning three continents. The result is a more universal and dynamic view of the shaping and reshaping of interactions between firms and universities within different countries at various stages of development. Read more about ...

  12. Funding | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    2018-09-30

    IDRC funds projects that aim to bring employment, food security, health, peace, and prosperity to developing regions of the world. We offer grants, funding, and awards to researchers and institutions to find ... Call for: Applications ... citizen of a developing country with a work permit in Canada valid until September 30, 2018;.

  13. [Landscape classification: research progress and development trend].

    Science.gov (United States)

    Liang, Fa-Chao; Liu, Li-Ming

    2011-06-01

    Landscape classification is the basis of the researches on landscape structure, process, and function, and also, the prerequisite for landscape evaluation, planning, protection, and management, directly affecting the precision and practicability of landscape research. This paper reviewed the research progress on the landscape classification system, theory, and methodology, and summarized the key problems and deficiencies of current researches. Some major landscape classification systems, e. g. , LANMAP and MUFIC, were introduced and discussed. It was suggested that a qualitative and quantitative comprehensive classification based on the ideology of functional structure shape and on the integral consideration of landscape classification utility, landscape function, landscape structure, physiogeographical factors, and human disturbance intensity should be the major research directions in the future. The integration of mapping, 3S technology, quantitative mathematics modeling, computer artificial intelligence, and professional knowledge to enhance the precision of landscape classification would be the key issues and the development trend in the researches of landscape classification.

  14. Entrepreneurship research in Spain: developments and distinctiveness.

    Science.gov (United States)

    Sánchez, José C; Gutiérrez, Andrea

    2011-08-01

    This article presents a review of research on entrepreneurship in Spain, paying particular attention to its beginnings, nature and main focus of interest. We have developed a database based on the review of 471 works produced between 1977 and 2009, including articles published in national and international journals and dissertations (read in Spain) that allowed us to extract the following results. There is a preference for qualitative methods, conceptual contributions and the entrepreneurial process as the privileged research theme. There is also a strong focus of interest on micro and small enterprises. These characteristics of Spanish research in areas of entrepreneurship can make a distinctive contribution to international research. However, the dissemination of knowledge and inadequate strategies for international publication limit the diffusion of Spanish research in entrepreneurship. Lastly, we discuss the implications for future research.

  15. Use of Random and Site-Directed Mutagenesis to Probe Protein Structure-Function Relationships: Applied Techniques in the Study of Helicobacter pylori.

    Science.gov (United States)

    Whitmire, Jeannette M; Merrell, D Scott

    2017-01-01

    Mutagenesis is a valuable tool to examine the structure-function relationships of bacterial proteins. As such, a wide variety of mutagenesis techniques and strategies have been developed. This chapter details a selection of random mutagenesis methods and site-directed mutagenesis procedures that can be applied to an array of bacterial species. Additionally, the direct application of the techniques to study the Helicobacter pylori Ferric Uptake Regulator (Fur) protein is described. The varied approaches illustrated herein allow the robust investigation of the structural-functional relationships within a protein of interest.

  16. Research Resources Survey: Radiology Junior Faculty Development.

    Science.gov (United States)

    Krupinski, Elizabeth A; Votaw, John R

    2015-07-01

    To assess resources available to junior faculty in US academic radiology departments for research mentorship and funding opportunities and to determine if certain resources are more common in successful programs. An anonymous survey covering scientific environment and research mentorship and was sent to vice-chairs of research of radiology departments. Results were evaluated to identify practices of research programs with respect to mentorship, resources, and opportunities. Academy of Radiology Research's 2012 National Institutes of Health (NIH) grants and awards list was used to determine if environment and practices correlate with funding. There was a 51% response rate. A greater fraction of clinical faculty gets promoted from assistant to associate professor than research faculty. Research faculty overall submits more funding applications. Most programs support start-up costs and K-awards. Over half of the departments have a vice-chair for faculty development, and most have formal mentorship programs. Faculty members are expected to teach, engage in service, publish, and apply for and get research funding within 3 years of hire. Top-tier programs as judged by NIH awards have a combination of MDs who devote >50% effort to research and PhD faculty. Key factors holding back both clinical and research junior faculty development were motivation, resources, and time, although programs reported high availability of resources and support at the department level. Better marketing of resources for junior faculty, effort devoted to mentoring clinical faculty in research, and explicit milestones/expectations for achievement could enhance junior faculty success, promote interest in the clinician–scientist career path for radiologists, and lead to greater research success.

  17. Developing Ethics and Standards in Action Research

    Directory of Open Access Journals (Sweden)

    Ben Boog

    2008-12-01

    Full Text Available In a globalizing world, what role can social science research – particularly action research – play in order to address the risks of exclusion, poverty, social and physical insecurity and environmental deprivation? More specifically, how can this type of research be conducted in a participatory, responsible, transparent and scientific way? In other words: what about the ethics and standards in action research? This was the main focus of the World Congress on Action Research and Action Learning (August 2006 organized by the University of Groningen and the Higher Education Group of the Northern Netherlands. We begin by discussing the core characteristics of action research with reference to theory and practice. Reflection and action are key constituents of the process through the enactment of action research. The middle section draws upon the research findings presented at the congress and published in a book [B. Boog, J. Preece, M. Slagter and J. Zeelen (Eds. (2008 Towards Quality Improvement of Action Research. Developing Ethics and Standards, Rotterdam/Taipei: Sense Publishers]. Citing authors who contributed chapters to the book mentioned above, we analyze four important subthemes: ‘participation, power and rapport’; ‘quality of research and quality management’; ‘learning to solve your own problems in complex responsive social systems, and ‘heuristics (rules of thumb for action research practice’. Finally, we comment on possible quality improvements for action research. Our remarks relate to the problems of implementing the concept of participation, the ambition of action research to contribute to both knowledge production and social change and the need for systematic reconstruction (scientific validation of action research.

  18. Research and development in power plant engineering

    International Nuclear Information System (INIS)

    Riedle, K.; Taud, R.

    2001-01-01

    Research and development are a bridge for visions that are escorted to a successful market introduction. Also in power plant engineering, research and development are a lever with which the product power plant, its technology and processes can be adapted to the quickly changing future market. In the overview given by this paper, therefore at first the development boosters and targets are outlined from the viewpoint of the market; then the available technology portfolio is addressed in a concise way. Targets for the development can be seen from the support programmes of the governments. Before a preview is given, some development topics from the point of view of the manufacturer are introduced. (orig.) [de

  19. Conformational change in full-length mouse prion: A site-directed spin-labeling study

    International Nuclear Information System (INIS)

    Inanami, Osamu; Hashida, Shukichi; Iizuka, Daisuke; Horiuchi, Motohiro; Hiraoka, Wakako; Shimoyama, Yuhei; Nakamura, Hideo; Inagaki, Fuyuhiko; Kuwabara, Mikinori

    2005-01-01

    The structure of the mouse prion (moPrP) was studied using site-directed spin-labeling electron spin resonance (SDSL-ESR). Since a previous NMR study by Hornemanna et al., [Hornemanna, Korthb, Oeschb, Rieka, Widera, Wuethricha, Glockshubera, Recombinant full-length murine prion protein, mPrP (23-231): purification and spectroscopic characterization, FEBS Lett. 413 (1997) 277-281] has indicated that N96, D143, and T189 in moPrP are localized in a Cu 2+ binding region, Helix1 and Helix2, respectively, three recombinant moPrP mutations (N96C, D143C, and T189C) were expressed in an Escherichia coli system, and then refolded by dialysis under low pH and purified by reverse-phase HPLC. By using the preparation, we succeeded in preserving a target cystein residue without alteration of the α-helix structure of moPrP and were able to apply SDSL-ESR with a methane thiosulfonate spin label to the full-length prion protein. The rotational correlation times (τ) of 1.1, 3.3, and 4.8 ns were evaluated from the X-band ESR spectra at pH 7.4 and 20 deg C for N96R1, D143R1, and T189R1, respectively. τ reflects the fact that the Cu 2+ binding region is more flexible than Helix1 or Helix2. ESR spectra recorded at various temperatures revealed two phases together with a transition point at around 20 deg C in D143R1 and T189R1, but not in N96R1. With the variation of pH from 4.0 to 7.8, ESR spectra of T189R1 at 20 deg C showed a gradual increase of τ from 2.9 to 4.8 ns. On the other hand, the pH-dependent conformational changes in N96R1 and D143R1 were negligible. These results indicated that T189 located in Helix2 possessed a structure sensitive to physiological pH changes; simultaneously, N96 in the Cu 2+ binding region and D143 in Helix1 were conserved

  20. Federal Research and Development Funding: FY2009

    Science.gov (United States)

    2009-05-22

    are funded through the NIH Management Fund, financed by taps on other NIH appropriations.) President Bush’s FY2009 budget proposal gave most of the... Alchemy of the 21st Century,” remarks, Texas Academy of Medicine, Engineering and Science Fourth Annual Conference, Austin, Texas, January 4, 2007...significant decrease in financing for MEP. Funding for in-house research and development under the Scientific and Technology Research and Services (STRS

  1. Rotorcraft research in India: recent developments

    OpenAIRE

    Ganguli, Ranjan

    2010-01-01

    Purpose - The purpose of this paper is to discuss published research in rotorcraft which has taken place in India during the last ten years The helicopter research is divided into the following parts health monitoring smart rotor design optimization control helicopter rotor dynamics active control of structural response (ACSR) and helicopter design and development Aspects of health monitoring and smart rotor are discussed in detail Further work needed and areas for international collaboration...

  2. Maturity Models Development in IS Research

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan; Vatrapu, Ravi; Andersen, Kim Normann

    2015-01-01

    Maturity models are widespread in IS research and in particular, IT practitioner communities. However, theoretically sound, methodologically rigorous and empirically validated maturity models are quite rare. This literature review paper focuses on the challenges faced during the development...... literature reveals that researchers have primarily focused on developing new maturity models pertaining to domain-specific problems and/or new enterprise technologies. We find rampant re-use of the design structure of widely adopted models such as Nolan’s Stage of Growth Model, Crosby’s Grid, and Capability...... Maturity Model (CMM). Only recently have there been some research efforts to standardize maturity model development. We also identify three dominant views of maturity models and provide guidelines for various approaches of constructing maturity models with a standard vocabulary. We finally propose using...

  3. Collaborative Engineering for Research and Development

    Science.gov (United States)

    Davis, Jose M.; Keys, L. Ken; Chen, Injazz J.

    2004-01-01

    Research and development (R&D) organizations are being required to be relevant, to be more application-oriented, and to be partners in the strategic management of the business while meeting the same challenges as the rest of the organization, namely: (1) reduced time to market; (2) reduced cost; (3) improved quality; (4) increased reliability; and (5) increased focus on customer needs. Recent advances in computer technology and the Internet have created a new paradigm of collaborative engineering or collaborative product development (CPD), from which new types of relationships among researchers and their partners have emerged. Research into the applicability and benefits of CPD in a low/no production, R&D, and/or government environment is limited. In addition, the supply chain management (SCM) aspects of these relationships have not been studied. This paper presents research conducted at the NASA Glenn Research Center (GRC) investigating the applicability of CPD and SCM in an R&D organization. The study concentrates on the management and implementation of space research activities at GRC. Results indicate that although the organization is engaged in collaborative relationships that incorporate aspects of SCM, a number of areas, such as development of trust and information sharing merit special attention.

  4. Tailor-Made Protein Tyrosine Phosphatases: In Vitro Site-Directed Mutagenesis of PTEN and PTPRZ-B

    NARCIS (Netherlands)

    Luna, S.; Mingo, J.; Aurtenetxe, O.; Blanco, L.; Amo, L.; Schepens, J.; Hendriks, W.J.A.J.; Pulido, R.

    2016-01-01

    In vitro site-directed mutagenesis (SDM) of protein tyrosine phosphatases (PTPs) is a commonly used approach to experimentally analyze PTP functions at the molecular and cellular level and to establish functional correlations with PTP alterations found in human disease. Here, using the

  5. One-Tube-Only Standardized Site-Directed Mutagenesis: An Alternative Approach to Generate Amino Acid Substitution Collections

    NARCIS (Netherlands)

    Mingo, J.; Erramuzpe, A.; Luna, S.; Aurtenetxe, O.; Amo, L.; Diez, I.; Schepens, J.T.G.; Hendriks, W.J.A.J.; Cortes, J.M.; Pulido, R.

    2016-01-01

    Site-directed mutagenesis (SDM) is a powerful tool to create defined collections of protein variants for experimental and clinical purposes, but effectiveness is compromised when a large number of mutations is required. We present here a one-tube-only standardized SDM approach that generates

  6. Site-directed fluorescence labeling of a membrane protein with BADAN: probing protein topology and local environment

    NARCIS (Netherlands)

    Koehorst, R.B.M.; Spruijt, R.B.; Hemminga, M.A.

    2008-01-01

    We present a new and simple method based on site-directed fluorescence labeling using the BADAN label that allows to examine protein-lipid interactions in great detail. We apply this approach to a membrane-embedded mainly -helical reference protein, the M13 major coat protein, of which in a

  7. Research and development for ethylbenzene production

    Energy Technology Data Exchange (ETDEWEB)

    Xue, Mingwei; Sun, Hongmin; Shen, Zhenhao; Zhang, Bin; Yang, Weimin [SINOPEC Shanghai Research Institute of Petrochemical Technology (China); Huan, Mingyao

    2013-11-01

    Ethylbenzene (EB) is important raw material for the production of styrene. Now, EB is mainly produced by the alkylation of benzene with ethylene catalyzed by zeolite in vapour phase or liquid phase. Shanghai Research Institute of Petrochemical Technology (SRIPT) began to research the catalysts for the production of ethylbenezene in 1993. With near 20 years work, three series of catalysts for the alkylation of benzene with pure ethylene, dilute ethylene and ethanol are in commerical in China. This paper mainly introduced the research and development of SRIPT for the EB production. (orig.)

  8. Management of research and development project

    International Nuclear Information System (INIS)

    Go, Seok Hwa; Hong Jeong Yu; Hyun, Byeong Hwan

    2010-12-01

    This book introduces summary on management of research and development project, prepare of research and development with investigation and analysis of paper, patent and trend of technology, structure of project, management model, management of project, management of project range, management of project time, management of project cost, management of project goods, management of project manpower, management of communication, management of project risk, management of project supply, management of outcome of R and D, management of apply and enroll of patent and management of technology transfer.

  9. Research and development in health education

    DEFF Research Database (Denmark)

    Wistoft, Karen

    2009-01-01

    relatable to health educational development. The overall value theme is elucidated by two development projects that transform as well as challenge specific health-educational practices. This forms the basis of the development of a critical, constructive and practice-oriented perspective on competence......Health professionals working in the field of health promotion and education experience certain value conflicts: their professional and personal values, the values of their clients or of the health services clash with pedagogic values such as participation, involvement, learning and competence...... development. My educational research is concerned with the exploration and development of the knowledge about values and health education related to competence development among health professionals. The purpose is to contribute to systematic knowledge development with a view to support and diversify...

  10. Combinatorial multispectral, thermodynamics, docking and site-directed mutagenesis reveal the cognitive characteristics of honey bee chemosensory protein to plant semiochemical.

    Science.gov (United States)

    Tan, Jing; Song, Xinmi; Fu, Xiaobin; Wu, Fan; Hu, Fuliang; Li, Hongliang

    2018-05-09

    In the chemoreceptive system of insects, there are always some soluble binding proteins, such as some antennal-specific chemosensory proteins (CSPs), which are abundantly distributed in the chemosensory sensillar lymph. The antennal-specific CSPs usually have strong capability to bind diverse semiochemicals, while the detailed interaction between CSPs and the semiochemicals remain unclear. Here, by means of the combinatorial multispectral, thermodynamics, docking and site-directed mutagenesis, we detailedly interpreted a binding interaction between a plant semiochemical β-ionone and antennal-specific CSP1 from the worker honey bee. Thermodynamic parameters (ΔH  0) indicate that the interaction is mainly driven by hydrophobic forces and electrostatic interactions. Docking prediction results showed that there are two key amino acids, Phe44 and Gln63, may be involved in the interacting process of CSP1 to β-ionone. In order to confirm the two key amino acids, site-directed mutagenesis were performed and the binding constant (K A ) for two CSP1 mutant proteins was reduced by 60.82% and 46.80% compared to wild-type CSP1. The thermodynamic analysis of mutant proteins furtherly verified that Phe44 maintained an electrostatic interaction and Gln63 contributes hydrophobic and electrostatic forces. Our investigation initially elucidates the physicochemical mechanism of the interaction between antennal-special CSPs in insects including bees to plant semiochemicals, as well as the development of twice thermodynamic analysis (wild type and mutant proteins) combined with multispectral and site-directed mutagenesis methods. Copyright © 2018. Published by Elsevier B.V.

  11. KSC Education Technology Research and Development Plan

    Science.gov (United States)

    Odell, Michael R. L.

    2003-01-01

    Educational technology is facilitating new approaches to teaching and learning science, technology, engineering, and mathematics (STEM) education. Cognitive research is beginning to inform educators about how students learn providing a basis for design of more effective learning environments incorporating technology. At the same time, access to computers, the Internet and other technology tools are becoming common features in K-20 classrooms. Encouraged by these developments, STEM educators are transforming traditional STEM education into active learning environments that hold the promise of enhancing learning. This document illustrates the use of technology in STEM education today, identifies possible areas of development, links this development to the NASA Strategic Plan, and makes recommendations for the Kennedy Space Center (KSC) Education Office for consideration in the research, development, and design of new educational technologies and applications.

  12. Circular dichroism and site-directed spin labeling reveal structural and dynamical features of high-pressure states of myoglobin

    Science.gov (United States)

    Lerch, Michael T.; Horwitz, Joseph; McCoy, John; Hubbell, Wayne L.

    2013-01-01

    Excited states of proteins may play important roles in function, yet are difficult to study spectroscopically because of their sparse population. High hydrostatic pressure increases the equilibrium population of excited states, enabling their characterization [Akasaka K (2003) Biochemistry 42:10875–85]. High-pressure site-directed spin-labeling EPR (SDSL-EPR) was developed recently to map the site-specific structure and dynamics of excited states populated by pressure. To monitor global secondary structure content by circular dichroism (CD) at high pressure, a modified optical cell using a custom MgF2 window with a reduced aperture is introduced. Here, a combination of SDSL-EPR and CD is used to map reversible structural transitions in holomyoglobin and apomyoglobin (apoMb) as a function of applied pressure up to 2 kbar. CD shows that the high-pressure excited state of apoMb at pH 6 has helical content identical to that of native apoMb, but reversible changes reflecting the appearance of a conformational ensemble are observed by SDSL-EPR, suggesting a helical topology that fluctuates slowly on the EPR time scale. Although the high-pressure state of apoMb at pH 6 has been referred to as a molten globule, the data presented here reveal significant differences from the well-characterized pH 4.1 molten globule of apoMb. Pressure-populated states of both holomyoglobin and apoMb at pH 4.1 have significantly less helical structure, and for the latter, that may correspond to a transient folding intermediate. PMID:24248390

  13. Physics Research Integrated Development Environment (PRIDE)

    International Nuclear Information System (INIS)

    Burton, J.; Cormell, L.

    1993-12-01

    Past efforts to implement a Software Engineering approach to High Energy Physics computing have been met with significant resistance and have been, in many cases, only marginally successful. At least a portion of the problem has been the Lick of an integrated development environment, tailored to High Energy Physics and incorporating a suite of Computer Aided Software Engineering tools. The Superconducting Super Collider Physics Research Division Computing Department is implementing pilot projects to develop just such an environment

  14. Virtual Reality: Directions in Research and Development.

    Science.gov (United States)

    Stuart, Rory

    1992-01-01

    Discussion of virtual reality (VR) focuses on research and development being carried out at NYNEX to solve business problems. Component technologies are described; design decisions are considered, including interactivity, connectivity, and locus of control; potential perils of VR are discussed, including user dissociation; and areas of promise are…

  15. Publications | Page 11 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 101 - 110 of 6341 ... ... widen the impact of our investment and advance development research. ... By 2030, the World Health Organization (WHO) projects that NCDs such as cancer, diabetes, ... Unravelling the interplay between youth socio-economic ... in Kenya and Uganda, where scientists are looking for cheaper, ...

  16. Publications | Page 29 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 281 - 290 of 6388 ... IDRC works with developing-country researchers and institutions to build local capacity ... to a high-level dialogue that engaged high-level officials and ... The Centers for International Projects Trust (CIPT) organized a ...

  17. Publications | Page 61 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 601 - 610 of 6389 ... IDRC works with developing-country researchers and institutions to ... The result is a more universal and dynamic view of the shaping and reshaping of interactions. ... Pathways to resilience : formal service and informal support use ... ability, divorce or death of their parents, cultural dislocation, and ...

  18. EPR: outlines of research and development

    International Nuclear Information System (INIS)

    Anon.

    1996-01-01

    The articles give an overview of the research and development presently under way for the future pressurized water reactors to be constructed in Europe, and particularly the French and German EPR (European Pressurized Reactor). Such an analysis deals essentially with respect to the pressurized water reactors now in operation. (author)

  19. UCLA accelerator research ampersand development. Progress report

    International Nuclear Information System (INIS)

    1997-01-01

    This report discusses work on advanced accelerators and beam dynamics at ANL, BNL, SLAC, UCLA and Pulse Sciences Incorporated. Discussed in this report are the following concepts: Wakefield acceleration studies; plasma lens research; high gradient rf cavities and beam dynamics studies at the Brookhaven accelerator test facility; rf pulse compression development; and buncher systems for high gradient accelerator and relativistic klystron applications

  20. Publications | Page 18 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 171 - 180 of 6341 ... IDRC works with developing-country researchers and institutions to build ... Any -, Central Asia, Europe, Far East Asia, Middle East, North and Central ... A series of four policy briefs show how poor governance practices, ... the Joint Declaration on ASEAN-Canada Enhanced Partnership 2016-2020.

  1. Publications | Page 47 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 461 - 470 of 6380 ... IDRC works with developing-country researchers and institutions to ... higher than that of men in India, though there is little difference in Brazil. ... partners working to build safe and inclusive cities in Africa, Asia, and Latin America. ... insurance framework to include the enabling conditions and risk ...

  2. Gender | Page 214 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Uncontrolled development was threatening to destroy the forest environment and the traditional way of life of the hill people of Ratanakiri. Researchers worked with the villagers to produce unique maps and resource use plans that convinced the government of the people's traditional resource use and management rights, ...

  3. Engineering Research in Irish Economic Development

    Science.gov (United States)

    Kelly, John

    2011-01-01

    This article summarizes the main findings and recommendations of a report published in December 2010 by the Irish Academy of Engineering (IAE). The report, representing the views of a committee of distinguished Irish engineers from a wide range of disciplines, addresses the role of engineering research in Ireland's economic development and the…

  4. Economics | Page 30 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Globalization is lauded by some as a tool for spreading peace and prosperity, and decried ... This book describes and analyzes the 3-year-long “L-20” project, whose ... in the environment for research and development (R&D) around the world. ... the “capability approach” of economist and Nobel Prize laureate Amartya Sen.

  5. Economics | Page 29 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Globalization is lauded by some as a tool for spreading peace and prosperity, and decried ... This book describes and analyzes the 3-year-long “L-20” project, whose ... in the environment for research and development (R&D) around the world. ... the “capability approach” of economist and Nobel Prize laureate Amartya Sen.

  6. Naval Medical Research and Development Strategic Plan

    Science.gov (United States)

    2008-03-01

    the strategic planning program for action. The pros and cons of the current NMR&D organization structure, management support funding, and officer...Distribution List D-4 Naval Medical Research and Development Strategic Plan March 2008 SWE Naval Surface Warfare Enterprise SWOT Strengths

  7. International Development Research Centre - Special Examination ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    OAG-BVG

    2008-03-27

    Mar 27, 2008 ... The government's attention to these matters is needed. .... that they can identify problems and make decisions that promote ... Canadian resources for research for development by creating, .... effect on the Centre's mandate and strategic objectives. ...... between fresh perspectives and corporate memory.

  8. Fuel Fabrication Capability Research and Development Plan

    Energy Technology Data Exchange (ETDEWEB)

    Senor, David J.; Burkes, Douglas

    2013-06-28

    The purpose of this document is to provide a comprehensive review of the mission of the Fuel Fabrication Capability (FFC) within the Global Threat Reduction Initiative (GTRI) Convert Program, along with research and development (R&D) needs that have been identified as necessary to ensuring mission success. The design and fabrication of successful nuclear fuels must be closely linked endeavors.

  9. Copyright | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Where copyright is held by IDRC Unless otherwise stated, the copyright to material on this website is held by the International Development Research Centre (IDRC). IDRC permits reading, downloading, copying, redistributing, printing, linking and searching, for non-commercial or academic purposes, of any of its content, ...

  10. Sudan | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Our research support has informed the peace and security work of the ... absence of a threat common to all bloc member states, and few shared political goals. ... spin-off, an internship program was developed that includes business, law, and ...

  11. Gender | Page 14 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Learning financial skills through involvement in an urban farming cooperative has improved the lives of women in Amman, Jordan. The article Developing Value Chains ... some form of physical disability. Despite these numbers, little research has been conducted to provide a window into the lives of people with disabilities.

  12. Publications | Page 2 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 11 - 20 of 7327 ... IDRC works with developing-country researchers and institutions to build local capacity through ... Fostering high growth enterprises is key to employment creation, productivity, and economic growth. ... Quality Assurance in Distance Education and eLearning: Challenges and Solutions from Asia.

  13. Publications | Page 16 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 151 - 160 of 6378 ... IDRC works with developing-country researchers and institutions to ... This is one of five cross-cutting issues that have emerged from early ... to a variety of solutions to prevent crime, including mental health support, ...

  14. Publications | Page 35 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 341 - 350 of 6381 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. ... The ''Quality Penalty'' refers to the provision of a facility, product, or service of low quality, which is still offered at a price similar to that of higher-quality. The.

  15. Journal of Research in National Development

    African Journals Online (AJOL)

    The Journal of Research in National Development aims to encourage interdisciplinary ... Favorite articles are quantitative, empirical and developmentally biased. .... Tax aggressiveness and corporate social responsibility fluidity in Nigerian firms ... By Country · List All Titles · Free To Read Titles This Journal is Open Access.

  16. Tanzania | Page 33 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    An international research team is developing nanotechnology-based applications of hexanal, a natural plant extract that extends the storage life of harvested fruit. Bananas, mangoes and papayas: these tender tropical fruits are in high demand in export markets and an important livelihood source for producers.

  17. Institutional Support : Ethiopian Development Research Institute ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Ethiopian Development Research Institute (EDRI) was established in 1999 and became operational in 2003 as a semi-autonomous organization accountable to ... International Water Resources Association, in close collaboration with IDRC, is holding a webinar titled “Climate change and adaptive water management: ...

  18. Gender | Page 212 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Research evidence is supporting the notion that involving women, along with ... The Centre has long valued industry, trade, and commerce as engines of economic growth. From its own practical support for private sector development, IDRC has ... du rôle joué par l'agriculture dans cette ville dynamique d'Afrique de l'Est.

  19. RESEARCH AND DEVELOPMENT INTO HERBAL MEDICINES ...

    African Journals Online (AJOL)

    Recent advances in the Research and development of Herbal Medicines are highlighted and a scheme for R & D work is presented. The need for adequate information (chemical, biological, botanical and so on) on local plants is highlighted. There is also the need to standardize the herbal product, prepare it in an ...

  20. Publications | Page 37 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 361 - 370 of 6373 ... This is the first study investigating the costs of smoking in Cambodia. Both primary and secondary data were collected for this research to provide scientific evidence of direct and indirect health-related costs attributable to smoking, in support of development and implementation of tobacco... Working ...

  1. Applied research opportunities in developed campgrounds

    Science.gov (United States)

    Carl P. Wiedemann

    2002-01-01

    Developed area camping is an important recreational activity in terms of both participation and as a source of revenue for public agencies. A major challenge for administrators in the public sector is how to increase revenues on limited budgets without sacrificing customer satisfaction. Applied research could make a valuable contribution to decision making, but not...

  2. Think Tank Initiative | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The UK Department for International Development. What we do · Funding · Resources · About IDRC. Knowledge. Innovation. Solutions. Careers · Contact Us · Site map. Sign up now for IDRC news and views sent directly to your inbox each month. Subscribe · Copyright · Open access policy · Privacy policy · Research ethics ...

  3. Publications | Page 35 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 341 - 350 of 7330 ... IDRC works with developing-country researchers and ... Using product space methodology, this project aims to analyze the existing ... Plant innate immune response: qualitative and quantitative ... This article discusses the contribution of the Community Work Programme (CWP) to social cohesion, ...

  4. Publications | Page 35 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 341 - 350 of 7331 ... IDRC works with developing-country researchers and institutions to ... Plant innate immune response: qualitative and quantitative ... This article discusses the contribution of the Community Work Programme (CWP) to social cohesion, ... Using product space methodology, this project aims to analyze ...

  5. Publications | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 1 - 10 of 7328 ... IDRC works with developing-country researchers and institutions to build local capacity through ... Visit the IDRC Digital Library now. ... For people living with disabilities that affect their mobility, it's almost impossible to get ...

  6. Economics | Page 19 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Today, just as businesses must compete for survival, growth, and market space, librarians and information professionals must assume a more proactive role to cope with increasing competition. Read more ... Relationships between social policy and human development are the subject of much research and theorizing.

  7. China | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    As the country's political influence in the world increases, we've supported the Chinese government's ... WORLD BANK/S.Harris ... build skills and knowledge to communicate research results and contribute to public debate. develop effective water resource management in the Asian Highlands in response to climate change.

  8. User account | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Log in(active tab) · Request new password. Username *. Enter your IDRC - International Development Research Centre username. Password *. Enter the password that accompanies your username. IDRC Login (for IDRC staff / team members only) · What we do · Funding · Resources · About IDRC. Knowledge. Innovation.

  9. Tradeoffs in Design Research: Development Oriented Triangulation

    NARCIS (Netherlands)

    Koen van Turnhout; Sabine Craenmehr; Robert Holwerda; Mark Menijn; Jan-Pieter Zwart; René Bakker

    2013-01-01

    The Development Oriented Triangulation (DOT) framework in this paper can spark and focus the debate about mixed-method approaches in HCI. The framework can be used to classify HCI methods, create mixed-method designs, and to align research activities in multidisciplinary projects. The framework is

  10. Publications | Page 8 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 71 - 80 of 6343 ... IDRC works with developing-country researchers and institutions to build local ... yet they are rarely valued or accounted for in the market economy. ... The Prospera Digital e-banking program aims to put money in the ...

  11. Government Research and Development Policy for Telecommunications.

    Science.gov (United States)

    Cohen, Linda

    This paper investigates how recent changes in the telecommunications industry are likely to affect government research and development policies by analyzing how changes in the market structure--in particular, increased competition in the industry due to domestic deregulation and international competition--change the political economy of government…

  12. Rationale for energy research and development programme

    Energy Technology Data Exchange (ETDEWEB)

    1976-04-01

    This paper describes the rationale for the expenditure of government money on energy research and development. The Committee, organized in 1974, established the following order of project priorities: projects to determine current and future energy demand; projects concerned with the conservation and more efficient use of energy; projects concerned with the assessment of indigenous energy resources; projects concerned with the assessment of the human, financial, and organizational resources for energy production and use; and projects concerned with economic, technological, social, and environmental aspects of energy use and production over the next 15 years and beyond the next 15 years. Significant factors affecting the national energy economy, the strategy for energy research and development, and the results of committee activities are summarized. An energy scenario research is laid out. (MCW)

  13. The development of laser fusion research

    International Nuclear Information System (INIS)

    Mima, Kunioki

    1998-01-01

    Laser fusion research started soon after the invention of laser. In 1972, the research was declassified and nuclear fusion by laser inplosion was proposed by J. Nuckolls. Since then, 26 years has passed and laser implosion experiments demonstrated 1000 times solid density compression. By the demonstration of 1000 times solid density, the mission of the laser fusion research shifted from 'implosion physics' to 'ignition and high gain', namely demonstration of fusion output of 100 times input laser energy. By the recent developments of laser technology, ultra intense laser became available and opened up a new ignition scheme which is called 'Fast Ignition'. The technology for the diode pumped solid state laser (DPSSL) is developed toward a laser driver for reactor. U.S. and France are constructing MJ lasers for demonstrating ignition and burn and Osaka University is investigating the fast ignition and the equivalent plasma of confinement (EPOC) toward high gain. (author)

  14. The development of laser fusion research

    Energy Technology Data Exchange (ETDEWEB)

    Mima, Kunioki [Osaka Univ., Suita (Japan). Inst. of Laser Engineering

    1998-11-01

    Laser fusion research started soon after the invention of laser. In 1972, the research was declassified and nuclear fusion by laser inplosion was proposed by J. Nuckolls. Since then, 26 years has passed and laser implosion experiments demonstrated 1000 times solid density compression. By the demonstration of 1000 times solid density, the mission of the laser fusion research shifted from `implosion physics` to `ignition and high gain`, namely demonstration of fusion output of 100 times input laser energy. By the recent developments of laser technology, ultra intense laser became available and opened up a new ignition scheme which is called `Fast Ignition`. The technology for the diode pumped solid state laser (DPSSL) is developed toward a laser driver for reactor. U.S. and France are constructing MJ lasers for demonstrating ignition and burn and Osaka University is investigating the fast ignition and the equivalent plasma of confinement (EPOC) toward high gain. (author)

  15. Research and Development Management System (RDMS)

    International Nuclear Information System (INIS)

    Mohd Azidi Abdul Rahman; Abdul Muin Abdul Rahman; Sufian Norazam Mohamed Aris; Saaidi Ismail; Mohamad Safuan Sulaiman; Maizura Ibrahim; Hazizi Omar; Roslan Mohd Ali

    2010-01-01

    Research and Development (R and D) is a main activity carried out at the Malaysian Nuclear Agency particularly in the physical science and nuclear field. The R and D activity that is carried out needs to be managed more efficiently and systematically. Until now all research management activities are carried out manually or semi electronically, beginning from filling in application forms to when the project is completed. Therefore a computerized system is needed in order to manage and monitor R and D projects. The R and D system is capable of giving access information concerning R and D projects which are carried out to users inside and outside the agency. The R and D management system (RDMS) can increase the capability of the Malaysian Nuclear Agency in managing, researching and developing, innovating and inventing technology as well as commercializing the R and D produced. (author)

  16. Competence Development among mentors: An Action Research

    DEFF Research Database (Denmark)

    Kragelund, Linda

    2014-01-01

    Artiklen er blevet dobbelt blind reviewet og jeg er i gang med at rette den til. This article presents results about student nurse mentors' competence development in relation to exploiting learning opportunities in everyday life activities in hospital wards. They are from the Danish action research...... about them. The research used the concept of 'pseudo-everyday life activities' in which hitherto undiscovered learning opportunities in everyday situations can be exploited, alongside Lauvås and Handal's 'Mentoring loop'. The research sought to establish how mentors’ competence could be improved using...... this framework. The analytical approach was qualitative content analysis. Results were not entirely as expected; they showed that when the tools were used as in the research design, mentors felt they benefitted and evidence indicated their competence would improve. Surprisingly, most mentors did not perform...

  17. Concept development for HLW disposal research tunnel

    International Nuclear Information System (INIS)

    Queon, S. K.; Kim, K. S.; Park, J. H.; Jeo, W. J.; Han, P. S.

    2003-01-01

    In order to dispose high-level radioactive waste in a geological formation, it is necessary to assess the safety of a disposal concept by excavating a research tunnel in the same geological formation as the host rock mass. The design concept of a research tunnel depends on the actual disposal concept, repository geometry, experiments to be carried at the tunnel, and geological conditions. In this study, analysis of the characteristics of the disposal research tunnel, which is planned to be constructed at KAERI site, calculation of the influence of basting impact on neighbor facilities, and computer simuation for mechanical stability analysis using a three-dimensional code, FLAC3D, had been carried out to develop the design concept of the research tunnel

  18. Are Project Developers Knights and Researchers Queens?

    DEFF Research Database (Denmark)

    Vinstrup, Anya Bjørn

    2014-01-01

    How do project developers at universities view their customers – the researchers, and how do they see themselves as a profession? Does this view influence their motivation and what challenges does it impose? Taking elements of theory from Public Service Motivation (PSM) and linking it with a small...... empirically based survey among the project developers at a centrally located office at a university in Denmark – these questions are sought to be answered. The focal point being the motivation of the project developer, with special emphasis on their user perception, and the practical implications it has...... for leadership and organisational structures....

  19. Unified fuel elements development for research reactors

    International Nuclear Information System (INIS)

    Vatulin, A.; Stetsky, Y.; Dobrikova, I.

    1998-01-01

    Square cross-section rod type fuel elements have been developed for russian pool-type research reactors. new fuel elements can replace the large nomenclature of tubular fuel elements with around, square and hexahedral cross-sections and to solve a problem of enrichment reduction. the fuel assembly designs with rod type fuel elements have been developed. The overall dimensions of existing the assemblies are preserved in this one. the experimental-industrial fabricating process of fuel elements, based on a joint extrusion method has been developed. The fabricating process has been tested in laboratory conditions, 150 experimental fuel element samples of the various sizes were produced. (author)

  20. Developing Short Films of Geoscience Research

    Science.gov (United States)

    Shipman, J. S.; Webley, P. W.; Dehn, J.; Harrild, M.; Kienenberger, D.; Salganek, M.

    2015-12-01

    In today's prevalence of social media and networking, video products are becoming increasingly more useful to communicate research quickly and effectively to a diverse audience, including outreach activities as well as within the research community and to funding agencies. Due to the observational nature of geoscience, researchers often take photos and video footage to document fieldwork or to record laboratory experiments. Here we present how researchers can become more effective storytellers by collaborating with filmmakers to produce short documentary films of their research. We will focus on the use of traditional high-definition (HD) camcorders and HD DSLR cameras to record the scientific story while our research topic focuses on the use of remote sensing techniques, specifically thermal infrared imaging that is often used to analyze time varying natural processes such as volcanic hazards. By capturing the story in the thermal infrared wavelength range, in addition to traditional red-green-blue (RGB) color space, the audience is able to experience the world differently. We will develop a short film specifically designed using thermal infrared cameras that illustrates how visual storytellers can use these new tools to capture unique and important aspects of their research, convey their passion for earth systems science, as well as engage and captive the viewer.

  1. 78 FR 28630 - Pfizer Therapeutic Research, Pfizer Worldwide Research & Development Division, Formerly Known as...

    Science.gov (United States)

    2013-05-15

    ... Research, Pfizer Worldwide Research & Development Division, Formerly Known as Warner Lambert Company... Groton, Connecticut location of Pfizer Therapeutic Research, Pfizer Worldwide Research & Development... Worldwide Research & Development Division, formerly known as Warner Lambert Company, Comparative Medicine...

  2. 1999 LDRD Laboratory Directed Research and Development

    Energy Technology Data Exchange (ETDEWEB)

    Rita Spencer; Kyle Wheeler

    2000-06-01

    This is the FY 1999 Progress Report for the Laboratory Directed Research and Development (LDRD) Program at Los Alamos National Laboratory. It gives an overview of the LDRD Program, summarizes work done on individual research projects, relates the projects to major Laboratory program sponsors, and provides an index to the principal investigators. Project summaries are grouped by their LDRD component: Competency Development, Program Development, and Individual Projects. Within each component, they are further grouped into nine technical categories: (1) materials science, (2) chemistry, (3) mathematics and computational science, (4) atomic, molecular, optical, and plasma physics, fluids, and particle beams, (5) engineering science, (6) instrumentation and diagnostics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) bioscience.

  3. Institutional research and development, FY 1988

    International Nuclear Information System (INIS)

    1988-01-01

    The Laboratory's Institutional Research and Development (IR and D) Program was established in 1984 to foster exploratory work to advance science and technology, disciplinary research to develop innovative solutions to support our national defense and energy missions. In FY 1988, the IR and D Program was funded by a 2% assessment on the Laboratory's operating budget. Our policy is to use these funds for researching innovative ideas in LLNL's areas of expertise and for developing new areas of expertise that we perceive to be in the national interest. The technical and scientific accomplishments of each project and of each institute funded this year are presented in this report. The projects were selected because they are expected to advance research in important areas that are too basic or too time consuming to be funded by the developmental programs or because they are somewhat risky projects that have the promise of high payoff. We are continually reappraising the IR and D Program. In particular, we seek new candidates for the Director's Initiatives, and we constantly reassess the work in progress. Each year, we make adjustments to further the Laboratory's policy of using the IR and D Program to fund innovative ideas with high potential for enhancing programmatic activities of national importance

  4. Institutional research and development, FY 1988

    Energy Technology Data Exchange (ETDEWEB)

    1988-01-01

    The Laboratory's Institutional Research and Development (IR and D) Program was established in 1984 to foster exploratory work to advance science and technology, disciplinary research to develop innovative solutions to support our national defense and energy missions. In FY 1988, the IR and D Program was funded by a 2% assessment on the Laboratory's operating budget. Our policy is to use these funds for researching innovative ideas in LLNL's areas of expertise and for developing new areas of expertise that we perceive to be in the national interest. The technical and scientific accomplishments of each project and of each institute funded this year are presented in this report. The projects were selected because they are expected to advance research in important areas that are too basic or too time consuming to be funded by the developmental programs or because they are somewhat risky projects that have the promise of high payoff. We are continually reappraising the IR and D Program. In particular, we seek new candidates for the Director's Initiatives, and we constantly reassess the work in progress. Each year, we make adjustments to further the Laboratory's policy of using the IR and D Program to fund innovative ideas with high potential for enhancing programmatic activities of national importance.

  5. Research and development program, fiscal year 1966

    Energy Technology Data Exchange (ETDEWEB)

    1964-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1966 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Chemical Toxicity; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine program may be summarized as follows: (1) investigation of the effects of ionizing radiation on living organisms and systems of biological significance; (2) investigation of the dynamic aspects of physiological and biochemical processes in man, animals and plants and how these processes are modified by radiation and related pathological states; (3) the assessment and study of the immediate and long term consequences of the operation or detonation of nuclear devices on the fauna, and flora in man's environment and on man; (4) the development of methods of minimizing or preventing the detrimental effects of ionizing radiation; (5) research in, and development of, beneficial uses of ionizing radiation and radioactive substances in medicine and biology; (6) research in the development of new and more efficient radiation detection devices; (7) research, including field studies, as mutually agreed upon by the Commission and the University, in connection with the conduct of weapon tests and biomedical and civil effects experiments at such tests conducted at continental and overseas test sites; and (8) the conduct of training and educational activities in the biological and medical aspects of radiation and related fields.

  6. 78 FR 28292 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2013-05-14

    ... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit Review Board; Notice of Meetings; Amendment The... Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development...

  7. Research and development of thorium fuel cycle

    International Nuclear Information System (INIS)

    Oishi, Jun.

    1994-01-01

    Nuclear properties of thorium are summarized and present status of research and development of the use of thorium as nuclear fuel is reviewed. Thorium may be used for nuclear fuel in forms of metal, oxide, carbide and nitride independently, alloy with uranium or plutonium or mixture of the compound. Their use in reactors is described. The reprocessing of the spent oxide fuel in thorium fuel cycle is called the thorex process and similar to the purex process. A concept of a molten salt fuel reactor and chemical processing of the molten salt fuel are explained. The required future research on thorium fuel cycle is commented briefly. (T.H.)

  8. Pellet injector research and development at ORNL

    International Nuclear Information System (INIS)

    Combs, S.K.; Barber, G.C.; Baylor, L.R.

    1994-01-01

    Oak Ridge National Laboratory has been developing pellet injectors for plasma fueling experiments on magnetic confinement devices for more than 15 years. Recent major applications of the ORNL development program include (1) a tritium-compatible four-shot pneumatic injector for the Tokamak Fusion Test Reactor, (2) a centrifuge pellet injector for the Tore Supra tokamak, and most recently (3) a three-barrel repeating pneumatic injector for the DIII-D tokamak. In addition to applications, ORNL is developing advanced technologies, including high-speed pellet injectors, tritium injectors, and long-pulse pellet feed systems. The high-speed research involves a collaboration between ORNL and ENEA-Frascati in the development of a repeating two-stage light gas gun based on an extrusion-type pellet feed system. Construction of a new tritium-compatible, extruder-based repeating pneumatic injector (8-mm-diam) is complete and will replace the pipe gun in the original tritium proof-of-principle experiment. The development of a steady-state feed system in which three standard extruders operate in tandem is under way. These research and development activities are relevant to the International Thermonuclear Experimental Reactor and are briefly described in this paper

  9. Exploratory research and development FY90

    International Nuclear Information System (INIS)

    Struble, G.L.; Middleton, C.; Baldwin, G.; Cherniak, J.; Clements, W.; Donohue, M.L.; Francke, A.; Kirvel, R.D.; MacGregor, P.; Shaw, G.

    1990-01-01

    In general, the Exploratory Research and Development (ER ampersand D) Program supports research projects considered too basic or long-range to be funded by other Lawrence Livermore National Laboratory (LLNL) programs. This Program is managed for the Laboratory Director by a special assistant who chairs the LLNL's IR ampersand D Review Committee. Membership in the Review Committee comprises senior LLNL scientists, engineers, and managers whose areas of expertise span the range of scientific disciplines pursued at the Laboratory. The research supported by the Program falls into three categories: Exploratory Research in the Disciplines, Director's Initiatives, and Laboratory-Wide Competition. The first two, Exploratory Research and Director's Initiatives, promote pioneering work in the various scientific disciplines and programmatic areas. Laboratory departments and divisions propose and manage projects in the Exploratory Research category. The Laboratory Director, with the advice of the Review Committee, selects several larger projects to fund as Director's Initiative. These projects, which are proposed and managed by the responsible associate director, are intended to enhance the scope of existing programs or establish new technical directions and programs for the Laboratory. All FY90 projects are described in detail in this report. Other publications on ER ampersand D projects are included in the Publications List at the back of this report

  10. Exploratory research and development FY90

    Energy Technology Data Exchange (ETDEWEB)

    Struble, G.L.; Middleton, C.; Baldwin, G.; Cherniak, J.; Clements, W.; Donohue, M.L.; Francke, A.; Kirvel, R.D.; MacGregor, P.; Shaw, G. (eds.)

    1990-01-01

    In general, the Exploratory Research and Development (ER D) Program supports research projects considered too basic or long-range to be funded by other Lawrence Livermore National Laboratory (LLNL) programs. This Program is managed for the Laboratory Director by a special assistant who chairs the LLNL's IR D Review Committee. Membership in the Review Committee comprises senior LLNL scientists, engineers, and managers whose areas of expertise span the range of scientific disciplines pursued at the Laboratory. The research supported by the Program falls into three categories: Exploratory Research in the Disciplines, Director's Initiatives, and Laboratory-Wide Competition. The first two, Exploratory Research and Director's Initiatives, promote pioneering work in the various scientific disciplines and programmatic areas. Laboratory departments and divisions propose and manage projects in the Exploratory Research category. The Laboratory Director, with the advice of the Review Committee, selects several larger projects to fund as Director's Initiative. These projects, which are proposed and managed by the responsible associate director, are intended to enhance the scope of existing programs or establish new technical directions and programs for the Laboratory. All FY90 projects are described in detail in this report. Other publications on ER D projects are included in the Publications List at the back of this report.

  11. Nuclear boom - challenge for research and development

    International Nuclear Information System (INIS)

    Korec, M.; Liska, P.

    2009-01-01

    In this lecture authors present research and development in which VUJE, a. s. has participated. Authors concluded that resume as soon as possible the short-term research and development tasks for the existing SE reactors, both, operational reactors of SE and for shut-downed reactors - JAVYS. (Financing with the contribution from the state but major part from the industry). In cooperation with state institutions, regulatory authorities and investor (would-be operator) and supplier (suppliers) define and prepare tasks focused on issues of new-built Generation III reactors (Financing split between the state and industry in accordance with the characteristics of the tasks). Begin preparing tasks for resolving development problems of Generation IV reactors: - Persuade politicians abut the inevitability of state participation in the process, including financing; - Involve in the process institutions that can significantly contribute to the problems resolving (mainly on technical level, but also on organization and potentially financial level); - Prepare international cooperation agreements in this field (based on the existing agreements, preparation of new agreements); - Define technical areas of cooperation (research infrastructure, experimental and development facilities, simulation tools).

  12. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.

    1991-12-01

    Today, new ideas and opportunities, fostering the advancement of technology, are occurring at an ever-increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of these new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and which develops new fundable'' R D projects and programs. At Brookhaven National Laboratory (BNL), one such method is through its Laboratory Directed Research and Development (LDRD) Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor achieving and maintaining staff excellence, and a means to address national needs, with the overall mission of the Department of Energy (DOE) and the Brookhaven National Laboratory. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals, and presentations at meetings and forums.

  13. Home economics in development through action research

    DEFF Research Database (Denmark)

    Benn, Jette

    2010-01-01

    This research study aimed at describing and developing home economics education through an action research approach in 2 schools and classes grade 6. The study went through 3 phases, an explorative phase with preliminary observations, interviews and discussions with teachers and pupils. Next...... in discursive phase changes have been implemented and conducted in accordance with findings. Third phase the explicative phase results were translated into text books for pupil's grade 4 to7 and to a teachers' guide. The subject is analysed theoretical through a model of the subject and research field. Findings...... and suggestions were discussed in relation to theories of learning, education and home economics. The overall perspectives were to involve pupils, to make them responsible by active and critical participation, and lastly to evaluate education in different ways....

  14. Case management: developing practice through action research.

    Science.gov (United States)

    Smith, Annetta; Mackay, Seonaid; McCulloch, Kathleen

    2013-09-01

    This article is a report of an action research study carried out with community nurses to help develop case management within their practice. Using action research principles, nurses reviewed and analysed their current practice and developed recommendations for further embedding case management as a means of supporting patients with complex care needs in their own homes. Findings indicate that a number of factors can influence the community nurse's ability to implement case management. These factors include approaches to case finding, availability of resources and interprofessional working. Important considerations for nurses were the influence of the context of care, the geographical location and the health needs of the local patient population, which meant that case management may need to be adapted to meet local circumstances.

  15. Development of Bioinformatics Infrastructure for Genomics Research.

    Science.gov (United States)

    Mulder, Nicola J; Adebiyi, Ezekiel; Adebiyi, Marion; Adeyemi, Seun; Ahmed, Azza; Ahmed, Rehab; Akanle, Bola; Alibi, Mohamed; Armstrong, Don L; Aron, Shaun; Ashano, Efejiro; Baichoo, Shakuntala; Benkahla, Alia; Brown, David K; Chimusa, Emile R; Fadlelmola, Faisal M; Falola, Dare; Fatumo, Segun; Ghedira, Kais; Ghouila, Amel; Hazelhurst, Scott; Isewon, Itunuoluwa; Jung, Segun; Kassim, Samar Kamal; Kayondo, Jonathan K; Mbiyavanga, Mamana; Meintjes, Ayton; Mohammed, Somia; Mosaku, Abayomi; Moussa, Ahmed; Muhammd, Mustafa; Mungloo-Dilmohamud, Zahra; Nashiru, Oyekanmi; Odia, Trust; Okafor, Adaobi; Oladipo, Olaleye; Osamor, Victor; Oyelade, Jellili; Sadki, Khalid; Salifu, Samson Pandam; Soyemi, Jumoke; Panji, Sumir; Radouani, Fouzia; Souiai, Oussama; Tastan Bishop, Özlem

    2017-06-01

    Although pockets of bioinformatics excellence have developed in Africa, generally, large-scale genomic data analysis has been limited by the availability of expertise and infrastructure. H3ABioNet, a pan-African bioinformatics network, was established to build capacity specifically to enable H3Africa (Human Heredity and Health in Africa) researchers to analyze their data in Africa. Since the inception of the H3Africa initiative, H3ABioNet's role has evolved in response to changing needs from the consortium and the African bioinformatics community. H3ABioNet set out to develop core bioinformatics infrastructure and capacity for genomics research in various aspects of data collection, transfer, storage, and analysis. Various resources have been developed to address genomic data management and analysis needs of H3Africa researchers and other scientific communities on the continent. NetMap was developed and used to build an accurate picture of network performance within Africa and between Africa and the rest of the world, and Globus Online has been rolled out to facilitate data transfer. A participant recruitment database was developed to monitor participant enrollment, and data is being harmonized through the use of ontologies and controlled vocabularies. The standardized metadata will be integrated to provide a search facility for H3Africa data and biospecimens. Because H3Africa projects are generating large-scale genomic data, facilities for analysis and interpretation are critical. H3ABioNet is implementing several data analysis platforms that provide a large range of bioinformatics tools or workflows, such as Galaxy, the Job Management System, and eBiokits. A set of reproducible, portable, and cloud-scalable pipelines to support the multiple H3Africa data types are also being developed and dockerized to enable execution on multiple computing infrastructures. In addition, new tools have been developed for analysis of the uniquely divergent African data and for

  16. Thorium research and development in Turkey

    International Nuclear Information System (INIS)

    Güngör, Görkem

    2015-01-01

    Turkey has a great potential regarding thorium resources. Thorium exploration activities have been done in the past mainly by state organizations for determining the thorium resources in Turkey. Thorium occurs as complex mineral together with barite, fluorite and rare earth elements (REE). The increase in global demand for REE creates the opportunity for REE production which will also produce thorium as a by-product. The development of nuclear energy program in Turkey provides the stimulus for research and development activities in nuclear technologies. The final declaration of the workshop emphasizes the importance of thorium reserves in Turkey and the necessity for thorium exploration and development activities in order to determine the feasibility of thorium mining and fuel cycle in Turkey. These activities should be conducted together with the development of technologies for separation of these complex minerals and purification of thorium, REE and other minerals to be utilized as commercial products. There are advanced academic research studies on thorium fuel cycle which should be supported by the industry in order to commercialize the results of these studies. Turkey should be integrated to international R and D activities on ADS which is expected to commercialize on medium term. The legislative framework should be developed in order to provide the industrial baseline for nuclear technologies independent from nuclear regulatory activities

  17. Laboratory Directed Research and Development FY 2000

    International Nuclear Information System (INIS)

    Hansen, Todd; Levy, Karin

    2001-01-01

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. Annual report on Laboratory Directed Research and Development for FY2000

  18. Research Thinking Development by Teaching Archaeoastronomy

    Science.gov (United States)

    Muglova, P. V.; Stoev, A. D.

    2006-08-01

    A model of research thinking development by teaching archaeoastronomy in specialized three-year extra-curriculum Astronomy programme and creation of favourable socio-educational surroundings is suggested. It is shown as a didactic system of conditions, influences and possibilities of answering specific hierarchic complex of personal needs in the 14 - 18 year age interval. Transformation of these needs in worldly values secures an active position of the students in the educational process and determines their personality development. It is also shown that the Archaeoastronomy School, as an educational environment, executes specific work of students' teaching, upbringing and progress as well as their inclusion in the real process of scientific research. Thus, they have the possibility of generating scientific ideas and obtaining results in the science archaeoastronomy. In consequence of this, their activity acquires social significance. Usages of this model of scientific school in the extra-curriculum Astronomy education reproduces norms and traditions of the real scientific research and directly relay subject content, cultural norms and values of archaeoastronomy in the educative process. Students' participation in archaeoastronomical expeditions, their competent work during the research of concrete archaeoastronomical objects create an investigation style of thinking and steady habits of scientific activity.

  19. Laboratory Directed Research and Development FY 2000

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Todd; Levy, Karin

    2001-02-27

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. Annual report on Laboratory Directed Research and Development for FY2000.

  20. Laboratory directed research and development FY91

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, S.E.; Hedman, I.; Kirvel, R.D.; McGregor, C.K. (eds.)

    1991-01-01

    This review of research programs at Lawrence Livermore National Laboratory is composed of individual papers on various subjects. Broad topics of interest are: chemistry and materials science, computation, earth sciences, engineering, nuclear physics, and physics, and biology. Director's initiatives include the development of a transgenic mouse, accelerator mass spectrometry, high-energy physics detectors, massive parallel computing, astronomical telescopes, the Kuwaiti oil fires and a compact torus accelerator. (GHH)

  1. Laboratory directed research and development FY91

    International Nuclear Information System (INIS)

    Anderson, S.E.; Hedman, I.; Kirvel, R.D.; McGregor, C.K.

    1991-01-01

    This review of research programs at Lawrence Livermore National Laboratory is composed of individual papers on various subjects. Broad topics of interest are: chemistry and materials science, computation, earth sciences, engineering, nuclear physics, and physics, and biology. Director's initiatives include the development of a transgenic mouse, accelerator mass spectrometry, high-energy physics detectors, massive parallel computing, astronomical telescopes, the Kuwaiti oil fires and a compact torus accelerator

  2. Industry Participation in Defence Research and Development,

    Science.gov (United States)

    1983-12-01

    Research and Development: Proposals for Additional Incentives. ASTEC , 1990. K . Interaction between Industry, Higher Education and Government Laboratories...Incentives for Innovation in Australian Industry. ASTEC , 1983. P. Bibliography. Distribution Document Control Data Sheet AWA I A& I 14l2 p/O)OIP (02... ASTEC and the Senate Committee on Science and the Environment. My Department is already preparing advice for me in this regard and I shall ask them to

  3. Research and development in alternative energy sources

    International Nuclear Information System (INIS)

    Lamptey, J.; Moo-Young, M.; Sullivan, H.F.

    1990-01-01

    This paper comprehensively discusses the various bioconversion and thermochemical processes. It recommends that the most urgent research and development issues should relate to direct microbial conversion systems for starch and cellulosic material and to basic biomass combustion rates and mechanisms. An overview of some of the major renewable energy resources and conversion technologies along with the potentials and problems associated with these are also presented.(author). 235 refs., 2 tabs

  4. Laboratory-directed research and development

    International Nuclear Information System (INIS)

    Gerstl, S.A.W.; Caughran, A.B.

    1992-05-01

    This report summarizes progress from the Laboratory-Directed Research and Development (LDRD) program during fiscal year 1991. In addition to a programmatic and financial overview, the report includes progress reports from 230 individual R ampersand D projects in 9 scientific categories: atomic and molecular physics; biosciences; chemistry; engineering and base technologies; geosciences; space sciences, and astrophysics; materials sciences; mathematics and computational sciences; nuclear and particle physics; and plasmas, fluids, and particle beams

  5. Thermostability enhancement of an endo-1,4-β-galactanase from Talaromyces stipitatus by site-directed mutagenesis

    DEFF Research Database (Denmark)

    Larsen, Dorte Møller; Nyffenegger, Christian; Swiniarska, Malgorzata Maria

    2015-01-01

    -life of TSGAL, nine single amino acid residues were selected for site-directed mutagenesis on the basis of semi-rational design. Of these nine mutants, G305A showed half-lives of 114 min at 55 °C and 15 min at 60 °C, respectively. This is 8.6-fold higher than that of the TSGAL at 55 °C, whereas the other...

  6. SiteFind: A software tool for introducing a restriction site as a marker for successful site-directed mutagenesis

    Directory of Open Access Journals (Sweden)

    Evans Paul M

    2005-12-01

    Full Text Available Abstract Background Site-directed mutagenesis is a widely-used technique for introducing mutations into a particular DNA sequence, often with the goal of creating a point mutation in the corresponding amino acid sequence but otherwise leaving the overall sequence undisturbed. However, this method provides no means for verifying its success other than sequencing the putative mutant construct: This can quickly become an expensive method for screening for successful mutations. An alternative to sequencing is to simultaneously introduce a restriction site near the point mutation in manner such that the restriction site has no effect on the translated amino acid sequence. Thus, the novel restriction site can be used as a marker for successful mutation which can be quickly and easily assessed. However, finding a restriction site that does not disturb the corresponding amino acid sequence is a time-consuming task even for experienced researchers. A fast and easy to use computer program is needed for this task. Results We wrote a computer program, called SiteFind, to help us design a restriction site within the mutation primers without changing the peptide sequence. Because of the redundancy of genetic code, a given peptide can be encoded by many different DNA sequences. Since the list of possible restriction sites for a given DNA sequence is not always obvious, SiteFind automates this task. The number of possible sequences a computer program must search through increases exponentially as the sequence length increases. SiteFind uses a novel "moving window" algorithm to reduce the number of possible sequences to be searched to a manageable level. The user enters a nucleotide sequence, specifies what amino acid residues should be changed in the mutation, and SiteFind generates a list of possible restriction sites and what nucleotides must be changed to introduce that site. As a demonstration of its use, we successfully generated a single point mutation

  7. Pellet injector research and development at ORNL

    International Nuclear Information System (INIS)

    Combs, S.K.; Argo, B.E.; Baylor, L.R.; Cole, M.J.; Dyer, G.R.; Fehling, D.T.; Fisher, P.W.; Foster, C.A.; Foust, C.R.; Gouge, M.J.; Jernigan, T.C.; Langley, R.A.; Milora, S.L.; Qualls, A.L.; Schechter, E.; Sparks, D.O.; Tsai, C.C.; Wilgen, J.B.; Whealton, J.W.

    1993-01-01

    A variety of pellet injector designs have been developed at ORNL including single-shot guns that inject one pellet, multiple-shot guns that inject four and eight pellets, machine gun-types (single- and multiple-barrel) that can inject up to >100 pellets, and centrifugal accelerators (mechanical devices that are inherently capable of high repetition rates and long-pulse operation). With these devices, macroscopic pellets (1--6 mm in diameter) composed of hydrogen isotopes are typically accelerated to speeds of ∼1.0 to 2.0 km/s for injection into plasmas of experimental fusion devices. In the past few years, steady progress has been made at ORNL in the development and application of pellet injectors for fueling present-day and future fusion devices. In this paper, we briefly describe some research and development activities at ORNL, including: (1) two recent applications and a new one on large experimental fusion devices, (2) high-velocity pellet injector development, and (3) tritium injector research

  8. Research and development quality assurance planning

    Energy Technology Data Exchange (ETDEWEB)

    Hoke, P.B.

    1990-05-14

    Planning for quality assurance (QA) in research and development (R D) is like stealing eggs without waking up the chickens. The QA program should be as unobtrusive as possible. Researchers require a QA program that affords them an environment capable of supporting repeatable experiments with accurate data without unduly stifling their creative abilities. Careful advance planning ensures that the intensity of control provided by quality-related systems is commensurate with the importance and scope of the activities being performed. Good scientific practices applied to small bench-scale projects may require minimal additional controls. As projects increase in size and complexity the controls imposed through planning must, by necessity, be increased. Research and development QA planning, just like any other planning, involves all affected individuals. The application of control systems is determined by factors such as customer or sponsor requirements, the importance of an item or activity to the experiment's success, and the organizational complexity of the project. Many larger experiments are highly dependent on quality-related support activities such as calibration, engineering design, and inspection provided by organizations outside the R D group. Since, in most cases, the expense of support activities is taken directly from funds available for research, it is important for the researchers to be involved in the planning efforts to help determine and agree with the level of QA effort required. A single plan will often suffice for organizations engaged in large numbers of similar experiments. Complex experiments may require unique QA plans or additions to existing plans. Once implemented, the R D QA plans, like any others, require audits or surveillances and may require revisions if the scope of the experiment changes. 1 ref., 1 fig.

  9. Research and development quality assurance planning

    International Nuclear Information System (INIS)

    Hoke, P.B.

    1990-01-01

    Planning for quality assurance (QA) in research and development (R ampersand D) is like stealing eggs without waking up the chickens. The QA program should be as unobtrusive as possible. Researchers require a QA program that affords them an environment capable of supporting repeatable experiments with accurate data without unduly stifling their creative abilities. Careful advance planning ensures that the intensity of control provided by quality-related systems is commensurate with the importance and scope of the activities being performed. Good scientific practices applied to small bench-scale projects may require minimal additional controls. As projects increase in size and complexity the controls imposed through planning must, by necessity, be increased. Research and development QA planning, just like any other planning, involves all affected individuals. The application of control systems is determined by factors such as customer or sponsor requirements, the importance of an item or activity to the experiment's success, and the organizational complexity of the project. Many larger experiments are highly dependent on quality-related support activities such as calibration, engineering design, and inspection provided by organizations outside the R ampersand D group. Since, in most cases, the expense of support activities is taken directly from funds available for research, it is important for the researchers to be involved in the planning efforts to help determine and agree with the level of QA effort required. A single plan will often suffice for organizations engaged in large numbers of similar experiments. Complex experiments may require unique QA plans or additions to existing plans. Once implemented, the R ampersand D QA plans, like any others, require audits or surveillances and may require revisions if the scope of the experiment changes. 1 ref., 1 fig

  10. Research of private label development in Croatia

    Directory of Open Access Journals (Sweden)

    Sandra Horvat

    2009-07-01

    Full Text Available Private labels have been present on the market since 19th century but their intensive market growth began in the last thirty years after retailers realized what their potential could be in the fight against ever-growing competition. Their market growth has not been distributed equally thought the world so Europe became the region with the highest private label market share, which exceeds 40% on some markets. Although the private label market share in Croatia is considerably smaller, it has also increased steadily over the last decade since private labels were introduced on the market. This paper presents the findings of a research conducted for the purpose of identifying trends in private label development on the Croatian market. The research was conducted through in-depth interviews with private label managers in retail companies in Croatia, and with the managers responsible for private label production in manufacturing companies. The research identified three expected trends of private label development in Croatia and these are: an increase in private label quality, the maintenance of a price gap between private labels and manufacturers’ brands and a further increase in the private label market share.

  11. Research and Development Annual Report, 1992

    Science.gov (United States)

    1993-01-01

    Issued as a companion to Johnson Space Center's Research and Technology Annual Report, which reports JSC accomplishments under NASA Research and Technology Operating Plan (RTOP) funding, this report describes 42 additional JSC projects that are funded through sources other than the RTOP. Emerging technologies in four major disciplines are summarized: space systems technology, medical and life sciences, mission operations, and computer systems. Although these projects focus on support of human spacecraft design, development, and safety, most have wide civil and commercial applications in areas such as advanced materials, superconductors, advanced semiconductors, digital imaging, high density data storage, high performance computers, optoelectronics, artificial intelligence, robotics and automation, sensors, biotechnology, medical devices and diagnosis, and human factors engineering.

  12. Safety management in research and development organisation

    International Nuclear Information System (INIS)

    Nivedha, T.

    2016-01-01

    Health and safety is one of the most important aspects of an organizations smooth and effective functioning. It depends on the safety management, health management, motivation, leadership and training, welfare facilities, accident statistics, policy, organization and administration, hazard control and risk analysis, monitoring, statistics and reporting. Workplace accidents are increasingly common, main causes are untidiness, noise, too hot or cold environments, old or poorly maintained machines, and lack of training or carelessness of employees. One of the biggest issues facing employers today is the safety of their employees. This study aims at analyzing the occupational health and safety of Research organization in Indira Gandhi Centre for Atomic Research by gathering information on health management, safety management, motivation, leadership and training, welfare facilities, accident statistics, organization and administration, hazard control and risk analysis, monitoring, statistics and reporting. Data were collected by using questionnaires which were developed on health and safety management system. (author)

  13. DGC - Research and development in the nineties

    International Nuclear Information System (INIS)

    Hinstrup, P.I.

    1992-01-01

    It is claimed that the world's total energy consumption in 1990 increased by 0.4%, whereas natural gas consumption increased by 1.9%. Natural gas comprises 21.6% of the world's consumption of primary energy. In western europe natural gas comprised 16% of the total fuel consumption, in the Northern countries the figure was 5% and in Denmark it constituted 10% of the total fuel consumption during 1990. The author describes the state of natural gas research activities generally throughout the world and emphasizes that the interest in environmental aspects is increasing. Research institutes working with natural gas abroad are briefly mentioned, and the technologies that attract greatest attention in Denmark are described. These include space heating in houses using natural gas - this market is expected to continue to develope. The use of natural gas in industry, and in the transportation sector as an alternative fuel, is also dealt with. (AB)

  14. Control of research oriented software development

    International Nuclear Information System (INIS)

    Lewis, L.C.; Dronkers, J.J.; Pitsker, B.

    1985-12-01

    The Nuclear Waste Policy Act of 1982 directs the Department of Energy (DOE) to dispose permanently high level radioactive waste and civilian spent nuclear fuel by January 31, 1998. DOE has responded by creating an organizational structure that directs all the activities necessary to carry out the legislative demands. LLNL is conducting research in the earth sciences and is developing some unique computer codes to help establish the feasibility of geologic repositories for nuclear waste. LLNL has several codes under development. This paper examines the administrative and organizational measures that were and still are being undertaken in order to control the development of the two major codes. In the case of one code, the software quality assurance requirements were imposed five years after the code began its development. This required a retroactive application of requirements. The other code is still in the conceptual stages of development and here requirements can be applied as soon as the initial code design begins. Both codes are being developed by scientists, not computer programmers, and both are modeling codes, not data acquisition and reduction codes. Also the projects for which these codes are being developed have slightly different software quality assurance requirements. All these factors contribute unique difficulties in attempts to assure that the development not only results in a reliable prediction, but that whatever the reliability, it can be objectively shown to exist. The paper will examine a software management model. It will also discuss the reasons why it is felt that this particular model would stand a reasonable chance for success. The paper will then describe the way in which the model should be integrated into the existing management configuration and tradition

  15. Laboratory Directed Research and Development FY 1992

    Energy Technology Data Exchange (ETDEWEB)

    Struble, G.L.; Middleton, C.; Anderson, S.E.; Baldwin, G.; Cherniak, J.C.; Corey, C.W.; Kirvel, R.D.; McElroy, L.A. [eds.

    1992-12-31

    The Laboratory Directed Research and Development (LDRD) Program at Lawrence Livermore National Laboratory (LLNL) funds projects that nurture and enrich the core competencies of the Laboratory. The scientific and technical output from the FY 1992 RD Program has been significant. Highlights include (1) Creating the first laser guide star to be coupled with adaptive optics, thus permitting ground-based telescopes to obtain the same resolution as smaller space-based instruments but with more light-gathering power. (2) Significantly improving the limit on the mass of the electron antineutrino so that neutrinos now become a useful tool in diagnosing supernovas and we disproved the existence of a 17-keV neutrino. (3) Developing a new class of organic aerogels that have robust mechanical properties and that have significantly lower thermal conductivity than inorganic aerogels. (4) Developing a new heavy-ion accelerator concept, which may enable us to design heavy-ion experimental systems and use a heavy-ion driver for inertial fusion. (5) Designing and demonstrating a high-power, diode-pumped, solid-state laser concept that will allow us to pursue a variety of research projects, including laser material processing. (6) Demonstrating that high-performance semiconductor arrays can be fabricated more efficiently, which will make this technology available to a broad range of applications such as inertial confinement fusion for civilian power. (7) Developing a new type of fiber channel switch and new fiber channel standards for use in local- and wide-area networks, which will allow scientists and engineers to transfer data at gigabit rates. (8) Developing the nation`s only numerical model for high-technology air filtration systems. Filter designs that use this model will provide safer and cleaner environments in work areas where contamination with particulate hazardous materials is possible.

  16. Laboratory Directed Research and Development FY 1992

    International Nuclear Information System (INIS)

    Struble, G.L.; Middleton, C.; Anderson, S.E.; Baldwin, G.; Cherniak, J.C.; Corey, C.W.; Kirvel, R.D.; McElroy, L.A.

    1992-01-01

    The Laboratory Directed Research and Development (LDRD) Program at Lawrence Livermore National Laboratory (LLNL) funds projects that nurture and enrich the core competencies of the Laboratory. The scientific and technical output from the FY 1992 RD Program has been significant. Highlights include (1) Creating the first laser guide star to be coupled with adaptive optics, thus permitting ground-based telescopes to obtain the same resolution as smaller space-based instruments but with more light-gathering power. (2) Significantly improving the limit on the mass of the electron antineutrino so that neutrinos now become a useful tool in diagnosing supernovas and we disproved the existence of a 17-keV neutrino. (3) Developing a new class of organic aerogels that have robust mechanical properties and that have significantly lower thermal conductivity than inorganic aerogels. (4) Developing a new heavy-ion accelerator concept, which may enable us to design heavy-ion experimental systems and use a heavy-ion driver for inertial fusion. (5) Designing and demonstrating a high-power, diode-pumped, solid-state laser concept that will allow us to pursue a variety of research projects, including laser material processing. (6) Demonstrating that high-performance semiconductor arrays can be fabricated more efficiently, which will make this technology available to a broad range of applications such as inertial confinement fusion for civilian power. (7) Developing a new type of fiber channel switch and new fiber channel standards for use in local- and wide-area networks, which will allow scientists and engineers to transfer data at gigabit rates. (8) Developing the nation's only numerical model for high-technology air filtration systems. Filter designs that use this model will provide safer and cleaner environments in work areas where contamination with particulate hazardous materials is possible

  17. Decommissioning Technology Development for Nuclear Research Facilities

    International Nuclear Information System (INIS)

    Lee, K. W.; Kang, Y. A.; Kim, G. H.

    2007-06-01

    It is predicted that the decommissioning of a nuclear power plant would happen in Korea since 2020 but the need of partial decommissioning and decontamination for periodic inspection and life extension still has been on an increasing trend and its domestic market has gradually been extended. Therefore, in this project we developed following several essential technologies as a decommissioning R and D. The measurement technology for in-pipe radioactive contamination was developed for measuring alpha/beta/gamma emitting nuclides simultaneously inside a in-pipe and it was tested into the liquid waste transfer pipe in KRR-2. And the digital mock-up system for KRR-1 and 2 was developed for choosing the best scenarios among several scenarios on the basis of various decommissioning information(schedule, waste volume, cost, etc.) that are from the DMU and the methodology of decommissioning cost estimation was also developed for estimating a research reactor's decommissioning cost and the DMU and the decommissioning cost estimation system were incorporated into the decommissioning information integrated management system. Finally the treatment and management technology of the irradiated graphites that happened after decommissioning KRR-2 was developed in order to treat and manage the irradiated graphites safely

  18. Decommissioning Technology Development for Nuclear Research Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Lee, K. W.; Kang, Y. A.; Kim, G. H. (and others)

    2007-06-15

    It is predicted that the decommissioning of a nuclear power plant would happen in Korea since 2020 but the need of partial decommissioning and decontamination for periodic inspection and life extension still has been on an increasing trend and its domestic market has gradually been extended. Therefore, in this project we developed following several essential technologies as a decommissioning R and D. The measurement technology for in-pipe radioactive contamination was developed for measuring alpha/beta/gamma emitting nuclides simultaneously inside a in-pipe and it was tested into the liquid waste transfer pipe in KRR-2. And the digital mock-up system for KRR-1 and 2 was developed for choosing the best scenarios among several scenarios on the basis of various decommissioning information(schedule, waste volume, cost, etc.) that are from the DMU and the methodology of decommissioning cost estimation was also developed for estimating a research reactor's decommissioning cost and the DMU and the decommissioning cost estimation system were incorporated into the decommissioning information integrated management system. Finally the treatment and management technology of the irradiated graphites that happened after decommissioning KRR-2 was developed in order to treat and manage the irradiated graphites safely.

  19. Decommissioning technology development for research reactors

    International Nuclear Information System (INIS)

    Lee, K. W.; Kim, S. K.; Kim, Y. K.

    2004-03-01

    Although it is expected that the decommissioning of a nuclear power plant will happen since 2020, the need of partial decommissioning and decontamination for periodic inspection and life extension has been on an increasing trend and domestic market has gradually been extended. Therefore, in this project the decommissioning DB system on the KRR-1 and 2 was developed as establishing the information classification system of the research reactor dismantling and the structural design and optimization of the decommissioning DB system. Also in order to secure the reliability and safety about the dismantling process, the main dismantling simulation technology that can verify the dismantling process before their real dismantling work was developed. And also the underwater cutting equipment was developed to remove these stainless steel parts highly activated from the RSR. First, the its key technologies were developed and then the design, making, and capability analysis were performed. Finally the actual proof was achieved for applying the dismantling site. an automatic surface contamination measuring equipment was developed in order to get the sample automatically and measure the radiation/radioactivity

  20. Research and Development Joint Development at CEEE - PUCRS

    Energy Technology Data Exchange (ETDEWEB)

    Haffner, Sergio L [Pontificia Univ. Catolica do Rio Grande do Sul, Porto Alegre, RS (Brazil). Escola Politecnica; Fagundes, Jose F. de O. [Companhia Estadual de Energia Eletrica do Estado do Rio Grande do Sul, Porto Alegre, RS (Brazil); Dias, Guilherme A.D.; Cecin, Carlos M

    1994-12-31

    The aim of this work is to present all events realized in Research and Development (R and D) by Companhia Estadual de Energia Eletrica (CEEE) and Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS) in the Electrical Power Systems area. In a brief report it is indicated a chronology of existing cooperation between CEEE and PUCRS, being introduced also the main events of that activity. Finally are showed the main activities performed in the Electrical Power Systems area. (author) 3 refs..

  1. Safeguards technology research and development at CIAE

    International Nuclear Information System (INIS)

    Yang Qun

    2001-01-01

    Full text: China Institute of Atomic Energy (CIAE) is a multi-disciplinary institute under the leadership of China National Nuclear Corporation (CNNC). The Laboratory of Technical Research for Nuclear Safeguards was established at CIAE in 1991 to develop safeguards technology and to provide technical assistance to competent authorities for nuclear material management and control, which became one of the key laboratories approved by CNNC in 1993. The main research works for safeguards at CIAE include: nuclear material control and accounting, facilities license review and assessment, domestic inspection, NDA and DA analysis, physical protection and technical training. Research and development of equipment and technique for safeguards has been continuing at CIAE. A variety of NDA equipment that has different resolution and analysis capability has been developed. Method of NDA measurement has been investigated for nuclear material with different characteristics. Mathematics method such as Monte Carlo simulation is applied in NDA. Advanced destructive analysis (DA) instrument is installed at laboratory of CIAE, such as TIMS, ICP-MS and electronic chemistry analyzing system. The high accuracy results of element analysis and isotopic analysis for nuclear material can be obtained. It is possible to measure the types and quantities of nuclear material in a given area by means of NDA and DA. Physical protection system has also been developed. It consists of access control and management, various alarm (including perimeter alarm, intrusion alarms, fire alarms), video and audio monitors, intercommunication set and central console. The system can meet technical requirement for safeguards of first rank. Nuclear material accounting is an important aspect of safeguards research at CIAE. The computer software related to material accounting has been developed. It is the important task for scientists at CIAE to design and review nuclear accounting systems in various facilities. For

  2. Nuclear energy research and development in France

    International Nuclear Information System (INIS)

    Patarin, L.

    1981-02-01

    Having described the general organization and main participants in charge of nuclear energy development in France, headed by the C.E.A. since the start of this activity at the end of World War II, the author gives a glimpse of the programmes shared out between four main headings: fundamental research, reactors, fuel cycle and nuclear safety. Two tables sum up the financial means of the C.E.A. in 1981 on the one hand and the personnel strengths on the other. A graph also shows the operational framework of the C.E.A. and its main subsidiaries and participations [fr

  3. Excellent fruits of national research and development

    International Nuclear Information System (INIS)

    2008-12-01

    This book introduces 100 excellent fruits of research and development in Korea. Such as. It show the titles of 100 excellent fruits about technology of hope to give people healthy life, technology of product and abundance to enrich resource, technology to make green growth and sound society, next service technology to communicate with network, new electron technology to brings life change, technology to draw innovation of industrial fields, technology to build higher value-added product with new fusion materials and technology to share and to create future knowledge.

  4. Quality assurance in research and development

    International Nuclear Information System (INIS)

    Laslett, G.F.; Waker, C.H.

    1990-01-01

    It is propounded that, given high status for the Research and Development (R and D) activity of the comapny or site, ''freeing'' the scientists and engineers involved at the innovative decision-taking point helps quality. Effort and money to raise the latter may be best spent in ensuring better calibre, background and training of them, making more meaningful the teamwork across the supplier/customer interfaces, and avoiding risk of misunderstanding of the use to be made of the outcome of the R and D endeavour. But the staff's conscience towards quality, hand in hand with safety, must be constantly stimulated. (author)

  5. 77 FR 26069 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2012-05-02

    ... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit Review Board, Notice of Meeting Amendment The... Development and Clinical Science Research and Development Services Scientific Merit Review Board have changed...

  6. Development of Global Change Research in Developing Countries

    Science.gov (United States)

    Sierra, Carlos A.; Yepes, Adriana P.

    2010-10-01

    Ecosystems and Global Change in the Context of the Neotropics; Medellín, Colombia, 19-20 May 2010; Research in most areas of global environmental change is overwhelmingly produced outside developing countries, which are usually consumers rather than producers of the knowledge associated with their natural resources. While there have been important recent advances in understanding the causes of global-¬scale changes and their consequences to the functioning of tropical ecosystems, there is still an important gap in the understanding of these changes at regional and national levels (where important political decisions are usually made). A symposium was held with the aim of surveying the current state of research activities in a small, developing country such as Colombia. It was jointly organized by the Research Center on Ecosystems and Global Change, Carbono and Bosques; the National University of Colombia at Medellín and the Colombian Ministry of the Environment, Housing, and Regional Development. This 2-¬day symposium gathered Colombian and international scientists involved in different areas of global environmental change, tropical ecosystems, and human societies.

  7. Trends of Photovoltaic Research, Development and Diffusion

    Energy Technology Data Exchange (ETDEWEB)

    Song, J. S.; Yoon, K. H.; Yu, K. J. [Korea Institute of Energy Research (Korea)

    2000-07-01

    The Korean National Photovoltaic Project was initiated on October 1989 to develop technologies for the generation of economically competitive electric power by photovoltaic systems. It consists of four stages through the year 2006 with technical goals and cost targets related with solar cells, balance of systems and system application. The objectives of the project are to utilize photovoltaic technology, to transfer developed technology to industries and end users by research activities and to diffuse photovoltaic systems by demonstration projects. This paper reviews long-term plan and status of technology R and D, and markets of photovoltaic. Some activities designed to promote collaboration with foreign countries are also introduced. (author). 14 refs., 3 figs., 3 tabs.

  8. Karlsruhe Nuclear Research Center. Research and development program 1991

    International Nuclear Information System (INIS)

    1990-01-01

    The R and D activities of the KfK are classified in 8 main research activities: 1) project nuclear fusion; 2) project pollutant mitigation in the environment; 3) solid state and materials research; 4) nuclear and elementary particle physics; 5) microtechnics e.g. X-ray lithography; 6) materials handling; 7) project nuclear safety research; 8) radioactive waste management. (orig.) [de

  9. 75 FR 74026 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2010-11-30

    ... DEPARTMENT OF ENERGY Biomass Research and Development Technical Advisory Committee AGENCY.... SUMMARY: This notice announces an open meeting of the Biomass Research and Development Technical Advisory... participation. This notice announces the meeting of the Biomass Research and Development Technical Advisory...

  10. Research and development in radiological protection

    International Nuclear Information System (INIS)

    Butragueno, J. L.; Villota, C.; Gutierrez, C.; Rodriguez, A.

    2004-01-01

    The objective of Radiological Protection is to guarantee that neither people, be they workers or members of the public, or the environment are exposed to radiological risks considered by society to be unacceptable. Among the various resources available to meet this objective is Research and Development (R and D), which is carried out in three areas: I. Radiological protection of persons: (a) knowledge of the biological effects of radiations, in order to determine the relationship that exists between radiation exposure dose and its effects on health; (b) the development of new personal dosimetry techniques in order to adapt to new situations, instrumental techniques and information management technologies allowing for better assessment of exposure dose; and (c) development of the principle of radiological protection optimisation (ALARA), which has been set up internationally as the fundamental principle on which radiological protection interventions are based. II. Assessment of environmental radiological impact, the objective of which is to assess the nature and magnitude of situations of exposure to ionising radiations as a result of the controlled or uncontrolled release of radioactive material to the environment, and III.Reduction of the radiological impact of radioactive wastes, the objective of which is to develop radioactive material and waste management techniques suitable for each situation, in order to reduce the risks associated with their definitive management or their release to the environment. Briefly described below are the strategic lines of R and D of the CSN, the Electricity Industry, Ciemat and Enresa in the aforementioned areas. (Author)

  11. Light-water reactor research and development

    International Nuclear Information System (INIS)

    1985-05-01

    This report on the national program of research and development on light water reactors is the second of two reports requested in 1982 by W. Kenneth Davis, Deputy Secretary of the Department of Energy. A first report, published in September 1983, treated the needs for safety-related R and D. In this second report, the Energy Research Advisory Board finds that, although many light water reactors are providing reliable and economic electricity, it appears unlikely that U.S. utilities will order additional reactors until the currently unacceptable economic risk, created by the regulatory climate and uncertain demand, is reduced. Thus it is unlikely that the private sector alone will fund major LWR design improvements. However, nuclear power will continue on its current course of expansion overseas. DOE participation is vitally needed to support the national interest in LWR technology. The report outlines R and D needs for a program to improve the safety, reliability, and economics of the present generation of plants; to develop evolutionary improved designs to be ready when needed; and to explore innovative longer-term concepts for deployment after the year 2000. The respective roles of government and the private sector are discussed

  12. New developments in transportation for research reactors

    Energy Technology Data Exchange (ETDEWEB)

    Mondanel, J.L. [Transnucleaire, F-75008 Paris (France)

    1998-07-01

    For more than 30 years, Transnucleaire has been performing safely a large number of national and international transports of radioactive material. Transnucleaire has also designed and supplied numerous packagings for all types of nuclear fuel cycle radioactive materials: for front-end and back-end products and for power and research reactors. Since the last meeting held in Bruges, Transnucleaire has been continuously involved in transportation activities for fresh and irradiated materials for research reactors. We are pleased to take the opportunity in this meeting to share with reactor operators, official bodies and other partners, the on-going developments in transportation and associated services. Special attention will be paid to the starting of transports of MTR spent fuel elements to the La Hague reprocessing plant where COGEMA offers reprocessing services on a long-term basis to reactors operators. Detailed information is provided on regulatory issues, which may affect transport activities: evolution of the regulations, real experiences of recent transportation and development of new packaging designs. Options and solutions will be proposed by Transnucleaire to improve the situation for continuation of national and international transports at an acceptable price whilst maintaining an ultimate level of safety (author)

  13. Is astronomical research appropriate for developing countries?

    Science.gov (United States)

    Snowden, Michael S.

    An unproductive 45-cm astronomical telescope, given by JICA (Japan) to Sri Lanka, raises general questions as to the reasons for unproductive pure science in developing countries. Before installation, site, maintenance, and scientific objectives were discussed. The facility was launched with a conference organised by the UN Office for Outer Space Affairs. Unfortunately, no research or significant education has resulted after four years. The annual operating cost is U.S. $5000 per year, including salary for a trainee, maintenance, and a modest promotional programme. Comparison with a similar installation in Auckland suggests lack of funding or technical competence do not explain the failure in Sri Lanka. The facility in New Zealand, on the roof of Auckland University's Physics Department, has a slightly smaller budget but has led to modest but useful research and teaching. Lack of financial backing and expertise are often blamed for weak science in developing countries, but examination shows most of these countries have adequately skilled people, and plenty of resources for religion and military. General lack of motivation for science appears to be the principal reason. This lack of interest and highly inefficient bureaucracies are common to scientifically unproductive countries. They mostly lack the cultural and philosophical base of the European Renaissance that motivate the pursuit of modern science, an activity that violates human preferences. There are excellent facilities (ESO, SAAO, Cerro Tololo, and GONG) in some of these same countries, when administered from the West.

  14. Waste and Disposal: Research and Development

    Energy Technology Data Exchange (ETDEWEB)

    Neerdael, B.; Marivoet, J.; Put, M.; Van Iseghem, P

    2001-04-01

    This contribution to the annual report describes the main activities of the Waste and Disposal Department of the Belgian Nuclear Research Center SCK-CEN. Achievements in 2000 in three topical areas are reported on: performance assessments, waste forms/packages and near- and far field studies. Performance assessment calculations were made for the geological disposal of high-level and long-lived waste in a clay formation. An impact assessment was completed for the radium storage facility at Olen (Belgium). Geological data, pumping rates and various hydraulic parameters were collected in support of the development of a new version of the regional hydrogeological model for the Mol site. Research and Development on waste forms and waste packages included both in situ and laboratory tests. Main emphasis in 2000 was on corrosion studies on vitrified high-level waste, the investigation of localised corrosion of candidate container and overpack materials and the study of the effect of the degradation of cellulose containing waste as well as of bituminized waste on the solubility and the sorption of Pu and Am in geological disposal conditions in clay. With regard to near- and far-field studies, percolation and diffusion experiments to determine migration parameters of key radionuclides were continued. The electromigration technique was used to study the migration of redox sensitive species like uranium. In addition to laboratory experiments, several large-scale migration experiments were performed in the HADES Underground Research Laboratory. In 2000, the TRANCOM Project to study the influence of dissolved organic matter on radionuclide migration as well as the RESEAL project to demonstrate shaft sealing were continued.

  15. Waste and Disposal: Research and Development

    International Nuclear Information System (INIS)

    Neerdael, B.; Marivoet, J.; Put, M.; Van Iseghem, P.

    2001-01-01

    This contribution to the annual report describes the main activities of the Waste and Disposal Department of the Belgian Nuclear Research Center SCK-CEN. Achievements in 2000 in three topical areas are reported on: performance assessments, waste forms/packages and near- and far field studies. Performance assessment calculations were made for the geological disposal of high-level and long-lived waste in a clay formation. An impact assessment was completed for the radium storage facility at Olen (Belgium). Geological data, pumping rates and various hydraulic parameters were collected in support of the development of a new version of the regional hydrogeological model for the Mol site. Research and Development on waste forms and waste packages included both in situ and laboratory tests. Main emphasis in 2000 was on corrosion studies on vitrified high-level waste, the investigation of localised corrosion of candidate container and overpack materials and the study of the effect of the degradation of cellulose containing waste as well as of bituminized waste on the solubility and the sorption of Pu and Am in geological disposal conditions in clay. With regard to near- and far-field studies, percolation and diffusion experiments to determine migration parameters of key radionuclides were continued. The electromigration technique was used to study the migration of redox sensitive species like uranium. In addition to laboratory experiments, several large-scale migration experiments were performed in the HADES Underground Research Laboratory. In 2000, the TRANCOM Project to study the influence of dissolved organic matter on radionuclide migration as well as the RESEAL project to demonstrate shaft sealing were continued

  16. Aerodynamics support of research instrument development

    Science.gov (United States)

    Miller, L. Scott

    1990-09-01

    A new velocimetry system is currently being developed at NASA LaRC. The device, known as a Doppler global velocimeter (DGV), can record three velocity components within a plane simultaneously and in near real time. To make measurements the DGV, like many other velocimetry systems, relies on the scattering of light from numerous small particles in a flow field. The particles or seeds are illuminated by a sheet of laser light and viewed by two CCD cameras. The scattered light from the particles will have a frequency which is a function of the source laser light frequency, the viewing angle, and most importantly the seed velocities. By determining the scattered light intensity the velocity can be measured at all points within the light sheet simultaneously. Upon completion of DGV component construction and initial check out a series of tests in the Basic Aerodynamic Research (wind) Tunnel (BART) are scheduled to verify instrument operation and accuracy. If the results are satisfactory, application of the DGV to flight measurements on the F-18 High Alpha Research Vehicle (HARV) are planned. The DGV verification test in the BART facility will utilize a 75 degree swept delta wing model. A major task undertaken this summer included evaluation of previous results for this model. A specific series of tests matching exactly the previous tests and exploring new DGV capabilities were developed and suggested. Another task undertaken was to study DGV system installation possibilities in the F-18 HARV aircraft. In addition, a simple seeding system modification was developed and utilized to make Particle Imaging Velocimetry (PIV) measurements in the BART facility.

  17. Research skills development in higher education students

    Directory of Open Access Journals (Sweden)

    Tiziana Priede Bergamini

    2014-03-01

    Full Text Available This case study presents the development of a research project in a third-year undergraduate course, Family Business Administration. The research project aimed at promoting research skills in students. The authors formed working groups of no more than six students, and each group had to select an original research topic after conducting a literature review. Students were guided by the teachers and provided with initial reading materials, as well as an activity rubric specifying the minimum requirements of a scientific paper. The activity evaluation consisted of two parts, a written article (group assessment and an oral presentation (individual assessment. After the activity concluded, students were asked to answer an online satisfaction survey. Results showed students viewed the activity as positive and appreciated the chance to develop several competencies, including research skills. The authors conclude several objectives were achieved, including: familiarize students with scientific research; make sure students are cable of finding information through primary sources; have students apply the knowledge acquired during the course; promote responsibility in students; cultivate in students the capacity to summarize ideas and expose them in a reasoned way; have students learn from the experiences and knowledge of others; and develop in students the capacity to synthesize all that information. -------------------------- El desarrollo de la capacidad investigadora en estudiantes de educación superior Resumen  Este estudio de caso presenta el desarrollo de un proyecto de investigación en la asignatura “Administración de la Empresa Familiar” de tercer curso. El proyecto de investigación tenía como propósito fomentar de forma específica la capacidad investigadora de los alumnos. Se formaron grupos de trabajo de no más de seis estudiantes, y cada grupo tenía que seleccionar un tema de investigación original tras realizar una búsqueda de

  18. Research and Development in the Anthropogenic Cryosphere

    Science.gov (United States)

    de Jong, C.; Luthe, T.; Hohenwallne, D.

    2009-04-01

    Much of todays cryosphere research is oriented towards the polar regions and is strongly supported by large associations and funding. On the other hand, funding and institutional support is still limited for mountains. In Europe, mountain research is mainly funded through Alpine Space Interregs, FP7, ESF and COST. However, there is growing global change pressure on mountain regions, particularly in the more fragile, higher altitudes such as between 1000 - 3200 m in the Alps. Although these zones are comparable to the Arctic in terms of climatic and physiographic conditions, they are not in terms of human pressures and atmospheric pollution released from surrounding agglomerations. A re-orientation of research into more applied projects that tackle present day problems is necessary. Not only is climate change rapidly changing the face of mountains, socio-economic multipliers are also acting fast. New problems such as conflicts over natural resources are evolving at a rapid rate, requiring research funding and projects to respond at according rates if timely and efficient solutions are to be proposed. Other problems include contamination of high altitude lakes and ecosystems through atmospheric precipitation of persistent organic pollutants and concentration of radio-active substances. The rapid melt of glacier ice is also releasing pollutants that have been captured for many decades. Many of the present day problems develop due to a miscomprehension of the cryosphere. Short-term economical reasoning outweighs the long-term ecological impacts that could be very counter-productive at the long term. Both the glaciological, snow, permafrost, geomorphological, ecological, hydrological and atmospheric conditions are increasingly heavily modified by human impacts. The effects include the alteration of the ice cover (by artificial covering of glaciers), production of artificial snow cover, snow and ground compaction, erosion, landsliding, change in vegetation cover and

  19. Research on geochemical exploration in geotherm development

    International Nuclear Information System (INIS)

    Hirowatari, Kazuo; Imaizumi, Yukio; Koga, Akito; Iwanaga, Tatsuto.

    1987-01-01

    The decisive factor of geotherm development is to improve the exploration techniques. By effectively carrying out the selection of promising development spots and the decision of well drilling positions, the geotherm development exceeding existing energy sources becomes feasible. There have been many problems in conventional geotherm exploration such as the high cost and long work period, therefore, it was decided to advance the research on geochemical exploration techniques which are relatively simple and can be carried out with low cost. When the techniques of geochemistry are used, for example, in the case that there are hot springs or fumaroles, the temperature, origin, properties and so on of underground hot water reservoirs can be estimated from their chemical composition. The method of examining the mercury concentration in soil and soil air has been in practical use in the geothermal districts where the ground surface symptom lacks. This time, the method of investigation using radon, thoron and gamma ray as the exploration indices was newly studied. The index compositions for geochemical exploration, new exploration index compositions, the method of measurement, the basic investigation and on-the-spot investigation are reported. (Kako, I.)

  20. Fast Charging Electric Vehicle Research & Development Project

    Energy Technology Data Exchange (ETDEWEB)

    Heny, Michael

    2014-03-31

    The research and development project supported the engineering, design and implementation of on-road Electric Vehicle (“EV”) charging technologies. It included development of potential solutions for DC fast chargers (“DCFC”) capable of converting high voltage AC power to the DC power required by EVs. Additional development evaluated solutions related to the packaging of power electronic components and enclosure design, as well as for the design and evaluation of EV charging stations. Research compared different charging technologies to identify optimum applications in a municipal fleet. This project collected EV usage data and generated a report demonstrating that EVs, when supported by adequate charging infrastructure, are capable of replacing traditional internal combustion vehicles in many municipal applications. The project’s period of performance has demonstrated various methods of incorporating EVs into a municipal environment, and has identified three general categories for EV applications: Short Commute: Defined as EVs performing in limited duration, routine commutes. - Long Commute: Defined as tasks that require EVs to operate in longer daily mileage patterns. - Critical Needs: Defined as the need for EVs to be ready at every moment for indefinite periods. Together, the City of Charlottesville, VA (the “City”) and Aker Wade Power Technologies, LLC (“Aker Wade”) concluded that the EV has a viable position in many municipal fleets but with limited recommendation for use in Critical Needs applications such as Police fleets. The report also documented that, compared to internal combustion vehicles, BEVs have lower vehicle-related greenhouse gas (“GHG”) emissions and contribute to a reduction of air pollution in urban areas. The enhanced integration of EVs in a municipal fleet can result in reduced demand for imported oil and reduced municipal operating costs. The conclusions indicated in the project’s Engineering Report (see Attachment

  1. Karlsruhe Nuclear Research Center. Research and development program 1992

    International Nuclear Information System (INIS)

    1991-01-01

    The KfK R and D activities are classified by ten point-of-main-effort projects: 1) low-pollution/low-waste methods, 2) environmental energy and mass transfers, 3) nuclear fusion, 4) nuclear saftey research, 5) radioactive waste management, 6) superconduction, 7) microtechnics, 8) materials handling, 9) materials and interfaces, 10) basic physical research. (orig.) [de

  2. India | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC-supported research in India has also focused on women's rights, security, and access ... Other IDRC employment-oriented research includes an initiative to help women ... enhance research quality at 43 public policy institutions in India.

  3. Search Results | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 1 - 10 of 9580 ... New partnership to support Ebola research teams ... population health research, and/or social science research in th ... Journal articles ... is a highly configurable open source electronic medical record system focused on ...

  4. Pakistan | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    For example, research in the Hindu Kush-Himalayas identified solutions to conserve soil ... This network specializes in applied research that connects economic and ... Groundbreaking research in Pakistan includes a study showing how the ...

  5. Development of quality assurance procedures for research and development

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Ji Hee

    2000-12-01

    The complexity and the diversity of R and D project are increasing and the life cycle in science and technology is getting shorter. It is required that the results of research and development are subject to prove their objectivity. KAERI is performing complex and various R and D projects. It is necessary that the principle of R and D QA should be applicated to projects for the efficient conduct of R and D and the objective and fair evaluation of the results. So, such requirements as are commonly applicable and necessary, regardless of the type of project and the degree of risk, are selected and QA procedures are established therewith.

  6. Development of quality assurance procedures for research and development

    International Nuclear Information System (INIS)

    Nam, Ji Hee

    2000-12-01

    The complexity and the diversity of R and D project are increasing and the life cycle in science and technology is getting shorter. It is required that the results of research and development are subject to prove their objectivity. KAERI is performing complex and various R and D projects. It is necessary that the principle of R and D QA should be applicated to projects for the efficient conduct of R and D and the objective and fair evaluation of the results. So, such requirements as are commonly applicable and necessary, regardless of the type of project and the degree of risk, are selected and QA procedures are established therewith

  7. Unorthodox Inhibitors of HIV Protease: Looking Beyond Active-site-directed Peptidomimetics

    Czech Academy of Sciences Publication Activity Database

    Schimer, Jiří; Konvalinka, Jan

    2014-01-01

    Roč. 20, č. 21 (2014), s. 3389-3397 ISSN 1381-6128 R&D Projects: GA ČR GAP207/11/1798 Institutional support: RVO:61388963 Keywords : proteinase * proteolytic processing * virostatic * rational drug design * resistance development Subject RIV: CE - Biochemistry Impact factor: 3.452, year: 2014

  8. Increase in D-tagatose production rate by site-directed mutagenesis of L-arabinose isomerase from Geobacillus thermodenitrificans.

    Science.gov (United States)

    Oh, Hyo-Jung; Kim, Hye-Jung; Oh, Deok-Kun

    2006-02-01

    Among single-site mutations of L-arabinose isomerase derived from Geobacillus thermodenitrificans, two mutants were produced having the lowest and highest activities of D-tagatose production. Site-directed mutagenesis at these sites showed that the aromatic ring at amino acid 164 and the size of amino acid 475 were important for D-tagatose production. Among double-site mutations, one mutant converted D-galactose into D-tagatose with a yield of 58% whereas the wild type gave 46% D-tagatose conversion after 300 min at 65 degrees C.

  9. Protein crystallography and site-direct mutagenesis analysis of the poly(ethylene terephthalate) hydrolase PETase from Ideonella sakaiensis.

    Science.gov (United States)

    Liu, Bing; He, Lihui; Wang, Liping; Li, Tao; Li, Changcheng; Liu, Huayi; Luo, Yunzi; Bao, Rui

    2018-03-30

    Compared with traditional recycle strategies, biodegradation provides a sustainable solution for poly (ethylene terephthalate) (PET) wastes disposal. PETase, a newly identified enzyme from Ideonella sakaiensis, has high efficiency and specificity towards PET, which provides a prominent prospect on PET degradation. Based on the biochemical analysis, we propose that the wide substrate-binding pocket is critical for its excellent property on crystallized PET hydrolysis. Structure-guided site-directed mutagenesis exhibited improvement in PETase catalytic efficiency, providing valuable insight on how the molecular engineering of PETase can optimize its application in biocatalysis. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Active site-directed alkylation of Na+-K+-ATPase by digitalis sulphonate derivatives of different lipophilicity.

    Science.gov (United States)

    Fricke, U.; Klaus, W.; Rogatti, M.

    1981-01-01

    1 Sulphonate derivatives of k-strophanthidin and digitoxigenin were tested as active site-directed labels of Na+-K+-adenosine triphosphatase (Na+-ATPase) from guinea-pig heart. 2 Lipophilicity ranged between P = 93 for strophanthidin-3-tosyloxy-acetate (STA) and P = 3028 for digitoxigenin-3-tosyloxy-acetate (DTA). 3 Although the alkylating moiety of STA and DTA was identical, the reversibility of Na+-K+-ATPase inhibition varied appreciably (82% and 35% respectively). 4 It is concluded that lipophilicity contributes considerably to the irreversible binding of alkylating cardiotonic steroids to myocardial Na+-K+-ATPase. PMID:6261865

  11. Recent developments in blood cell labeling research

    Energy Technology Data Exchange (ETDEWEB)

    Srivastava, S.C.; Straub, R.F.; Meinken, G.E.

    1988-09-07

    A number of recent developments in research on blood cell labeling techniques are presented. The discussion relates to three specific areas: (1) a new in vitro method for red blood cell labeling with /sup 99m/Tc; (2) a method for labeling leukocytes and platelets with /sup 99m/Tc; and (3) the use of monoclonal antibody technique for platelet labeling. The advantages and the pitfalls of these techniques are examined in the light of available mechanistic information. Problems that remain to be resolved are reviewed. An assessment is made of the progress as well as prospects in blood cell labeling methodology including that using the monoclonal antibody approach. 37 refs., 4 figs.

  12. Research and development: widening the energy horizon

    Energy Technology Data Exchange (ETDEWEB)

    Darmstadter, J.; Landsberg, H.H.; Morton, H.C.

    1984-04-01

    Research and Development (R and D) is not a recent phenomenon. Only the name is new; the substance is old. Such scientists as Alessandro Volta, James Watt, or Thomas Edison would have been surprised to be told that they were in the R and D business, but, of course, they were. In fact, Edison was in the RDD and D business, the extra two D's standing for Demonstration and Deployment. In their lifetime such people were generally called inventors. Today, there are not only multitudes of individuals who engage in R and D, in small or large commercial groups, in government laboratories, or in universities, but there is also a substantial literature on just what R and D is and how it functions. In this article the authors try to identify current trends and where they might lead us and what policies are either in place or are desirable to draw the greatest benefit from R and D endeavors.

  13. Research and development program, fiscal year 1970

    Energy Technology Data Exchange (ETDEWEB)

    1968-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1970 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine Program may be summarized as follows: (1) investigation of the effects of ionizing radiation on systems of biological significance and on living organisms; (2) assessment and study of the immediate and long term consequences of the environmental radioactivity on flora, fauna, and man; (3) development of beneficial uses of ionizing radiation and radioactive substances in medicine and biology; and (4) the conduct of training and educational activities in fields related to the biological and medical aspects of radiation.

  14. Recent developments in blood cell labeling research

    International Nuclear Information System (INIS)

    Srivastava, S.C.; Straub, R.F.; Meinken, G.E.

    1988-01-01

    A number of recent developments in research on blood cell labeling techniques are presented. The discussion relates to three specific areas: (1) a new in vitro method for red blood cell labeling with /sup 99m/Tc; (2) a method for labeling leukocytes and platelets with /sup 99m/Tc; and (3) the use of monoclonal antibody technique for platelet labeling. The advantages and the pitfalls of these techniques are examined in the light of available mechanistic information. Problems that remain to be resolved are reviewed. An assessment is made of the progress as well as prospects in blood cell labeling methodology including that using the monoclonal antibody approach. 37 refs., 4 figs

  15. Recent Developments in Scientific Research Ballooning

    International Nuclear Information System (INIS)

    Jones, W. Vernon

    2007-01-01

    The National Aeronautics and Space Administration (NASA) Balloon Program is committed to meeting the need for extended duration scientific investigations by providing advanced balloon vehicles and support systems. A sea change in ballooning capability occurred with the inauguration of 8 - 20 day flights around Antarctica in the early 1990's. The attainment of 28-31 day flights and a record-breaking 42-day flight in, respectively, two and three circumnavigations of the continent has greatly increased the expectations of the scientific users. A new super-pressure balloon is currently under development for future flights of 60-100 days at any latitude, which would bring another sea change in scientific research ballooning

  16. Particle Detectors: Research and Development at CERN

    International Nuclear Information System (INIS)

    Fabjan, C. W.

    2008-01-01

    Over the past 15 years a worldwide Detector R and D Programme has made the LHC experiments possible. These experiments operate at a new level of event rate and detection capabilities. Based on these advances, Detector R and D is continuing at CERN in close collaboration with University and Research Institutes. Several main directions are being pursued for solid-state and gaseous tracking devices, advanced crystal and noble liquid calorimetry, particle identification methods, and advanced signal-processing techniques. This effort is directed towards experiments at even higher collision rates at the LHC, the requirements for the next generation of linear electron-positron colliders and for applications outside particle physics, such as medical diagnostics instrumentation. We shall illustrate this challenging, stimulating and creative programme with examples and show how these developments are taking place in close collaboration between CERN and institutions around the globe

  17. Developing Action Research for Developing Teachers in Kosovo

    Directory of Open Access Journals (Sweden)

    Eda Vula

    2015-10-01

    Full Text Available This study explores the perception of student teachers on their role as researchers and the impact of action research in their professional development. The study involves the master level student teachers of the Faculty of Education at the University of Prishtina in Kosovo. Qualitative data collected through reflective writing, open-ended questionnaires and research reports developed by student teachers were analyzed through the inductive method. The study suggests that teacher research has a major impact not only on the improvement of teaching practices and increasing student achievement, but also on increasing the collaboration among peers and fostering a new culture where teachers assume their responsibilities to apply action research in their own classrooms as a tool for classroom transformation. Teacher education and school context are crucial in this matter and the need arises to avoid viewing the development of teacher research as an isolated activity.Keywords: Action research, professional development, student teacher, environmentÖzBu araştırma, öğrenci öğretmenlerin araştırmacı rollerini algılamalarını ve profesyonel gelişimlerinde eylem araştırmaların etkisini incelemektedir. Araştırma, Priştine Üniversitesi Eğitim Fakültesi’nde yüksek lisans düzeyinde olan öğrenci öğretmenleri kapsamaktadır. Öğrenciler tarafından yapılan yansıtıcı yazılar, açık uçlu soru formları ve araştırma raporlarından toplanan nitel veriler tümevarım yöntemi aracılığıyla incelenmiştir. Araştırma, öğretmen araştırmalarının, sadece öğretim uygulamalarının geliştirilmesine ve öğrenci başarısının yükseltilmesine değil, aynı zamanda yaşıtlar arası işbirliğini arttırma ve öğretmenlerin sınıfı dönüştürme aracı olarak kendi sınıflarında eylem araştırmasını uygulama sorumluluğunu yeni bir kültür olarak teşvik etmeye önemli bir etkisinin olduğunu ortaya koymaktad

  18. Biomedical engineering for health research and development.

    Science.gov (United States)

    Zhang, X-Y

    2015-01-01

    Biomedical engineering is a new area of research in medicine and biology, providing new concepts and designs for the diagnosis, treatment and prevention of various diseases. There are several types of biomedical engineering, such as tissue, genetic, neural and stem cells, as well as chemical and clinical engineering for health care. Many electronic and magnetic methods and equipments are used for the biomedical engineering such as Computed Tomography (CT) scans, Magnetic Resonance Imaging (MRI) scans, Electroencephalography (EEG), Ultrasound and regenerative medicine and stem cell cultures, preparations of artificial cells and organs, such as pancreas, urinary bladders, liver cells, and fibroblasts cells of foreskin and others. The principle of tissue engineering is described with various types of cells used for tissue engineering purposes. The use of several medical devices and bionics are mentioned with scaffold, cells and tissue cultures and various materials are used for biomedical engineering. The use of biomedical engineering methods is very important for the human health, and research and development of diseases. The bioreactors and preparations of artificial cells or tissues and organs are described here.

  19. The early research and development of ebselen.

    Science.gov (United States)

    Parnham, Michael J; Sies, Helmut

    2013-11-01

    Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one; PZ-51, DR-3305), is an organoselenium compound with glutathione peroxidase (GPx)-like, thiol-dependent, hydroperoxide reducing activity. As an enzyme mimic for activity of the selenoenzyme GPx, this compound has proved to be highly useful in research on mechanisms in redox biology. Furthermore, the reactivity of ebselen with protein thiols has helped to identify novel, selective targets for inhibitory actions on several enzymes of importance in pharmacology and toxicology. Importantly, the selenium in ebselen is not released and thus is not bioavailable, ebselen metabolites being excreted in bile and urine. As a consequence, initial concerns about selenium toxicity, fortunately, were unfounded. Potential applications in medical settings have been explored, notably in brain ischemia and stroke. More recently, there has been a surge in interest as new medical applications have been taken into consideration. The first publication on the biochemical effects of ebselen appeared 30 years ago (Müller et al.), which prompted the authors to retrace the early development from their perspective. It is a fascinating example of fruitful interaction between research-oriented industry and academia. Copyright © 2013 Elsevier Inc. All rights reserved.

  20. Developing preceptorship through action research: Part 1.

    Science.gov (United States)

    Hilli, Yvonne; Melender, Hanna-Leena

    2015-09-01

    Clinical preception in practice plays a significant role in both registered and practical nurse studies. As such, the cooperation between the faculty and working life is important to narrow the theory-practice gap, with emphasis being placed on a student-oriented approach promoting self-direction and lifelong learning. The aim of this project was to develop the preceptorship at five different units within the health-care sector in western Finland by implementing an action research (AR) approach. This article is the first of a two-part article on the project, focusing on a cultural analysis and the development of preception models conducted within the project. The five units participating in the study were the following: a long-term care ward in the community, a ward for people with dementia, a geriatric ward, a medical ward and a surgical ward representing specialised care. The starting point of the study was a cultural analysis, which was made in all the five units to obtain a 'bottom-up' perspective. In each of the five units 3-5 nurses were appointed to become members of the core groups. This meant that all the units would start from the perspective of their own working environment when creating a preception model that would fit into their particular workplace. During this process, the participants received continuous support from the researchers. Several workshops and seminars were also arranged to further support the core groups and staff. The models were implemented and tested during the academic year 2010-2011 followed by an evaluation of the project. The evaluation results will be presented in the second part of the two-part article. The project showed that reflective practice and critical thinking can be improved through an AR approach. © 2015 Nordic College of Caring Science.

  1. Site-directed mutagenesis of the foot-and-mouth disease virus RNA-polymerase gene

    International Nuclear Information System (INIS)

    Brindeiro, R.M.; Soares, M.A.; Vianna, A.L.M.; Pontes, O.H.A. de; Pacheco, A.B.F.; Almeida, D.F. de; Tanuri, A.

    1991-01-01

    The foot-and-mouth disease virus RNA-polymerase gene was mutagenised in its active site. Pst I digestion of the polymerase gene (cDNA) generated a 790 bp fragment containing the critical sequence. This fragment was subcloned in M13mp8 for mutagenesis method. The polymerase gene was then reconstructed and subcloned in pUC19. These mutants will be used to study the enzyme structure and activity and to develop intracellular immunization assays in eukaryotic cells. (author)

  2. Dynamic selection of ship responses for estimation of on-site directional wave spectra

    DEFF Research Database (Denmark)

    Andersen, Ingrid Marie Vincent; Storhaug, Gaute

    2012-01-01

    -estimate of the wave spectrum is suggested. The selection method needs to be robust for what reason a parameterised uni-directional, two-parameter wave spectrum is treated. The parameters included are the zero up-crossing period, the significant wave height and the main wave direction relative to the ship’s heading...... with the best overall agreement are selected for the actual estimation of the directional wave spectrum. The transfer functions for the ship responses can be determined using different computational methods such as striptheory, 3D panel codes, closed form expressions or model tests. The uncertainty associated......Knowledge of the wave environment in which a ship is operating is crucial for most on-board decision support systems. Previous research has shown that the directional wave spectrum can be estimated by the use of measured global ship responses and a set of transfer functions determined...

  3. Karlsruhe Nuclear Research Center. Research and development programme 1988

    International Nuclear Information System (INIS)

    1987-01-01

    A general survey of planned activities and developmental trends of the nuclear research centre is followed by a more detailed account of projects and goals. The various institutes and laboratories are presented together with their specific task schedules. (UA) [de

  4. Renewable energy research and development in Canada

    Energy Technology Data Exchange (ETDEWEB)

    Chappell, M S

    1979-12-01

    Canadian research and development (R and D) in renewable energy began as a result of the oil crisis in 1974, and in keeping with government policy, is predominantly carried out in the private sector under contract to the federal government. The variety in technical maturity of the renewable energy technologies is reflected in the non-uniform funding levels among the five constituent programs. The greatest support is allotted to solar energy in recognition of its enormous potential, both in low to mid-temperature thermal and in photovoltaic applications. This report describes the technical content of these five renewable energy and R and D programs, and outlines the organization and management structures used to direct the effort. Biomass energy R and D concentrates on the harvesting, processing and conversion of wood wastes into convenient fuel forms. Near-term applications will continue to be in the forest products industries. Wind energy R and D in geothermal energy are focussed on identification and quantification of the resource. A five-megawatt experimental geothermal heating system is being established at the University of Regina. The hydraulic energy R and D program does not consider conventional hydro-electric systems which are well developed; rather, it primarily covers laboratory-scale tests on conversion devices for wave, tidal, and river flow energy systems. A substantial effort is also underway in analytic and modelling techniques for hydraulic energy systems of all types. 3 figs., 2 tabs.

  5. Laboratory Directed Research and Development Program

    International Nuclear Information System (INIS)

    Ogeka, G.J.; Romano, A.J.

    1992-12-01

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium

  6. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.; Romano, A.J.

    1992-12-01

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium.

  7. Research and development of JT-60 tokamak

    International Nuclear Information System (INIS)

    Saito, Ryusei; Sato, Hiroshi; Murata, Toshifumi; Ito, Yoshiyasu.

    1978-01-01

    The development of nuclear fusion apparatuses for the purpose of utilizing energy due to nuclear fusion reaction has been forwarded in various countries, and in Japan, the critical plasma testing apparatus JT-60 is about to be constructed, centering around Japan Atomic Energy Research Institute. This is one of four large apparatuses to be constructed in the world, and it is expected to be completed in 1982. JT-60 is a nuclear fusion apparatus of tokamak type aiming at generating critical plasma. The features of JT-60 are the formation of the plasma with small aspect ratio, the equipment of a magnetic limiter, the arrangement of the first wall of molybdenum and high temperature baking as the measures to impurities. The large toroidal magnetic field coil of JT-60 is composed of 18 unit coils. The analyses of magnetic field, thermal behavior and structural strength, the selection of materials, and the development of manufacturing techniques regarding the toroidal coil are described. The vacuum container of JT-60 is composed of the main body of torus type comprising thickwalled rings and bellows, the first wall comprising liners, fixed limiter and magnetic limiter, and observation ports. It is large torus-form container with non-circular cross section, and baking at 500 deg. C is required as the measure to ultrahigh vacuum. Complex forces including electromagnetic force act on it. (Kako, I.)

  8. Karlsruhe Nuclear Research Center. Research and development programme 1989

    International Nuclear Information System (INIS)

    1988-01-01

    The R and D activities of the KfK are classified in 10 main research activities: 1) Project fast breeder; 2) separation nozzle method; 3) project nuclear fusion; 4) project reprocessing and waste processing; 5) ultimate storage; 6) environment and safety; 7) solid-state and materials research; 8) nuclear and elementary particle physics; 9) microtechnics e.g. X-ray lithography; 10) materials handling. (HP) [de

  9. 7 CFR 916.45 - Marketing research and development.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Marketing research and development. 916.45 Section 916... GROWN IN CALIFORNIA Order Regulating Handling Research § 916.45 Marketing research and development. The... research, marketing research and development projects designed to assist, improve, or promote the marketing...

  10. Research and Development on nuclear fission

    International Nuclear Information System (INIS)

    2007-01-01

    Research and development activities on advanced and innovative reactors are performed within a domestic programme and international initiatives. The ongoing New Nuclear Fission National Programme is synergic and complementary to the International Nuclear Energy Initiative (INERI) and EURATOM framework programmes and is managed by ENEA through a specific agreement signed in June 2007 by the Italian Ministry for Economic Development (MSE). The activities concern an integral advanced pressurised light-water-cooled reactor (IRIS nuclear power plant [NPP]) and several Generation-4. fast reactors: lead-cooled, very high temperature and sodium-cooled. A summary of the main results achieved in 2007 follows. In the framework of the INERI programme ENEA and other Italian organisations are involved in the design of the International Reactor Innovative and Secure (IRIS NPP), particularly in the design certification. An appropriate integral testing programme will be performed in the SPES-3 facility to be built at the SIET laboratories in Piacenza. The facility will be located inside the building of the decommissioned Emilia oil-fired power plant. Once erected, the facility will simulate IRIS at full height, full pressure and temperature, and with volumes and power scaled by factors of 1:100 and 1:150, respectively. The activity will be carried out in a collaboration with Oak Ridge National Laboratory (ORNL), USA under an international initiative concerning cooperation in the field of nuclear-related technologies of mutual interest. In 2007 activities were mainly devoted to the conceptual design of the SPES-3 facility, the development of SPES-3 nodalization and the seismic isolation analysis of the IRIS auxiliary building

  11. Developments in cooperative learning: review of research

    Directory of Open Access Journals (Sweden)

    Robyn M. Gillies

    2014-10-01

    Full Text Available Cooperative learning, where students work in small groups to accomplish shared goals, is widely recognized as a teaching strategy that promotes learning and socialization among students from kindergarten through college and across different subject domains. It has been used successfully to promote reading and writing achievements, understanding and conceptual development in science classes, problem-solving in mathematics, and higher-order thinking and learning to name just a few. It has been shown to enhance students' willingness to work cooperatively and productively with others with diverse learning and adjustment needs and to enhance intergroup relations with those from culturally and ethnically different backgrounds. It has also been used as a teaching strategy to assist students to manage conflict and to help students identified as bullies learn appropriate interpersonal skills. In fact, it has been argued that cooperative learning experiences are crucial to preventing and alleviating many of the social problems related to children, adolescents, and young adults. There is no doubt that the benefits attributed to cooperative learning are widespread and numerous and it is the apparent success of this approach to learning that has led to it being acclaimed as one of the greatest educational innovations of recent times. The purpose of this paper is not only to review developments in research on cooperative learning but also to examine the factors that mediate and moderate its success. In particular, the review focuses on the types of student and teacher interactions generated and the key role talk plays in developing student thinking and learning, albeit through the expression of contrasting opinions or constructed shared meaning. The intention is to provide additional insights on how teachers can effectively utilize this pedagogical approach to teaching and learning in their classrooms.

  12. When Research Meets Development: Antecedents and Implications of Transfer Speed

    NARCIS (Netherlands)

    Du, J.; Leten, B.; Vanhaverbeke, W.; Lopez-Vega, H.

    2014-01-01

    This paper focuses on the organization of new product development in large, R&D-intensive firms. In these firms, research and development activities are often separated. Research is conducted in dedicated research projects at specialized research labs. Once research results are achieved by research

  13. Nurses' experiences of participation in a research and development programme

    DEFF Research Database (Denmark)

    Jensen, Kirsten Pryds; Bäck-Pettersson, Siv; Kýlén, Sven

    2013-01-01

    To describe clinical nurses' experience of participating in a Research and Development (R&D) programme and its influence on their research interest and ability to conduct and apply nursing research......To describe clinical nurses' experience of participating in a Research and Development (R&D) programme and its influence on their research interest and ability to conduct and apply nursing research...

  14. 48 CFR 31.205-48 - Research and development costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Research and development... Organizations 31.205-48 Research and development costs. Research and development, as used in this subsection... grant for research and development effort, the excess is unallowable under any other Government contract...

  15. What we do | Page 22 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC supports research in developing countries to create real and lasting change. ... providing developing-country researchers with financial resources, advice, and ... Explore more than 1,000 research projects we've supported over the past ...

  16. What we do | Page 28 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC supports research in developing countries to create real and lasting change. ... providing developing-country researchers with financial resources, advice, and ... Explore more than 1,000 research projects we've supported over the past ...

  17. 48 CFR 731.773 - Independent research and development costs.

    Science.gov (United States)

    2010-10-01

    ... Organizations 731.773 Independent research and development costs. Pending establishment of Government-wide... independent research and development costs. ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Independent research and...

  18. Life Cycle Impact Assessment Research Developments and Needs

    Science.gov (United States)

    Life Cycle Impact Assessment (LCIA) developments are explained along with key publications which record discussions which comprised ISO 14042 and SETAC document development, UNEP SETAC Life Cycle Initiative research, and research from public and private research institutions. It ...

  19. R-prime site-directed transposon Tn7 mutagenesis of the photosynthetic apparatus in Rhodopseudomonas capsulata

    Energy Technology Data Exchange (ETDEWEB)

    Youvan, D C [Univ. of California, Berkeley; Elder, J T; Sandlin, D E; Zsebo, K; Alder, D P; Panopoulos, N J; Marrs, B L; Hearst, J E

    1982-01-01

    Site-directed mutagenesis of the photosynthetic apparatus (PSA) genes in Rhodopseudomonas capsulata is presented utilizing a transposon Tn7 mutagenized R-prime. The R-prime, pRPS404, bears most of the genes necessary for the differentiation of the photosynthetic apparatus. Mutagenesis of the R-prime with Tn7 in Escherichia coli, conjugation into R. capsulata, and homologous recombination with the wild-type alleles efficiently generates photosynthetic apparatus lesions. Wild-type alleles are lost spontaneously and the Tn7-induced lesions are revealed by subsequent intramolecular recombination between IS21 insertion elements that bracket the prime sequences in direct repeat. The molecular nature of the intermediates involved in the transposition, recombination and deletion have been investigated by Southern hybridization analysis. The spontaneous loss of wild-type alleles after homologous recombination with the chromosome may be of general use to other prokaryotic site-directed transposon mutagenesis schemes. The IS21-mediated deletion of the prime DNA is dependent on the RecA protein in E. coli, generating the parental R-factor bearing one IS21 element. A genetic-physical map exists for a portion of the prime photosynthetic apparatus DNA. When Tn7 is inserted into a bacteriochlorophyll gene in the R-prime and then crossed into R. capsulata, mutants are produced that accumulate a bacteriochlorophyll precursor, which is in excellent agreement with the existing genetic-physical map. This corroborates the mutagenesis scheme.

  20. In vivo elimination of parental clones in general and site-directed mutagenesis.

    Science.gov (United States)

    Holland, Erika G; Acca, Felicity E; Belanger, Kristina M; Bylo, Mary E; Kay, Brian K; Weiner, Michael P; Kiss, Margaret M

    2015-02-01

    The Eco29k I restriction endonuclease is a Sac II isoschizomer that recognizes the sequence 5'-CCGCGG-3' and is encoded, along with the Eco29k I methylase, in the Escherichia coli strain 29k. We have expressed the Eco29k I restriction-methylation system (RM2) in E. coli strain TG1 to produce the strain AXE688. We have developed a directed molecular evolution (DME) mutagenesis method that uses Eco29k I to restrict incoming parental DNA in transformed cells. Using our DME method, we have demonstrated that our AXE688 strain results in mutated directed molecular evolution libraries with diversity greater than 10(7) from a single transformation and with greater than 90% recombinant clones. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Direct site-directed photocoupling of proteins onto surfaces coated with β-cyclodextrins

    DEFF Research Database (Denmark)

    Städe, Lars W; Wimmer, Reinhard; Stensballe, Allan

    2010-01-01

    . Insertion of pBpa was verified by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectroscopy. A molecular dynamic simulation, with water as solvent, showed high solvent accessibility of the pBpa benzophenone group in N27pBpa-cutinase mutant. The formation of an inclusion......A method called Dock'n'Flash was developed to offer site-specific capture and direct UVA-induced photocoupling of recombinant proteins. The method involves the tagging of recombinant proteins with photoreactive p-benzoyl-L-phenylalanine (pBpa) by genetic engineering. The photoreactive pBpa tag...... is used for affinity capture of the recombinant protein by beta-cyclodextrin (beta-CD), which provides hydrogen atoms to be abstracted in the photocoupling process. To exemplify the method, a recombinant, folded, and active N27pBpa mutant of cutinase from Fusarium solani pisi was produced in E. coli...

  2. Developing the Developers: Supporting and Researching the Learning of Professional Development Facilitators

    Science.gov (United States)

    Perry, Emily; Boylan, Mark

    2018-01-01

    Research on teacher professional development is extensive but there are fewer studies about the practitioners who facilitate professional development. Here we report on a pilot programme for professional development facilitators rooted in a cycle of action research. Informed by a categorisation of professional knowledge and skills of facilitators,…

  3. Myanmar | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    The project supports research on employer and employee needs in Myanmar, ... and evidence to inform policymakers, researchers are analyzing productivity, social ... labour-related laws and regulations to increase fairness; increase Burmese ...

  4. Resources | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Through IDRC's resource library, we share our results, provide support to ... Our Research Support team provides the resources and tools researchers need to ... It also includes information on how to structure and design your policy brief to ...

  5. Southern African Development Research Network | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... to craft policies for fruitful integration into the global economy and inclusive growth. ... The grant will support a broad-based research network, the Southern Africa ... researchers based in regional institutions; transforming selected institutions ...

  6. Publications | Page 65 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 641 - 650 of 7327 ... Series profiles the experiences of young researchers working with the CARIAA program ... Asia (CARIAA) is a natural environment in which to expand their ... A new article by researchers working with the Safe and ...

  7. Economics | Page 16 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... reasons for South Africa's poor manufacturing performance over the past 20 years. ... Avril Joffe is a Research Associate in the Sociology of Work Unit at the ... in gender and health research: women and AIDS, tropical disease, the working ...

  8. Perspectives | Page 3 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2017-05-09

    Ideas from the global climate change hotspot research. What are the major findings from the research happening in the three climate change hotspot areas? Published date: May 9, 2017. Author(s): Bruce Currie-Alder ...

  9. Colombia | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Our research support in the country has contributed to the peace process in several ... and equality in rural areas, a group of Colombian researchers, business leaders, and civil society representatives is advising government policy to enhance ...

  10. Zimbabwe | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... for research and higher education when we began supporting research there in 1981. ... indigenous vegetables, helping raise awareness of their nutritional value. ... In 2011, Zimbabwe's Ministry of Health and Child Welfare adopted some of ...

  11. Senegal | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Our funded research has reduced poverty, and improved urban agriculture and ... one of our research grantees showed city residents how to treat wastewater with an aquatic plant. Treated water can then be safely used to irrigate gardens.

  12. Developing theory-driven design research

    DEFF Research Database (Denmark)

    Cash, Philip J.

    2018-01-01

    Design research is increasingly weak in comparison with other fields; without action to increase scientific, theoretical, and methodological rigour there is a real possibility of the field being superseded and becoming obsolete through lack of impact. The aim of this paper is to show how design r....... I identify key learning indicating future directions for theory-driven design research. I conclude by providing some concrete recommendations for the field of design research and individual design researchers....

  13. Research and Development Concerning Coalbed Natural Gas

    Energy Technology Data Exchange (ETDEWEB)

    William Ruckelshaus

    2008-09-30

    quality, most of it is discharged to surface drainages or to soil (for irrigation). CBNG water quality generally declines when moving from the Cheyenne River drainage northwestward to the Belle Fourche, Little Powder, and Powder River drainages and in the central and western part of the PRB, most CBNG water goes to evaporation-infiltration ponds or is discharged directly to surface drainages. Concerns center on the salinity of the water, usually measured as total dissolved solids (TDS), or electrical conductivity (EC) and sodium adsorption ratio (SAR). Other management options currently in use include injection, managed irrigation (with additives to mitigate the effects of high salinity), atomization, and treatment by reverse osmosis or ion exchange. A key water quality issue is the cumulative effect of numerous CBNG water discharges on the overall water quality of basin streams. This leads to one of the most contentious issues in CBNG development in Wyoming's PRB: Montana's concern about the potential downstream effects of water quality degradation on rivers flowing north into Montana. Many of the benefits and costs associated with CBNG development have been debated, but dealing with CBNG water quantity and quality arguably has been the most difficult of all the issues. Given the importance of these issues for continued development of CBNG resources in Wyoming and elsewhere, the DOE-NETL funded project presented here focuses on CBNG co-produced water management. The research was organized around nine separate, but interrelated, technical project tasks and one administrative task (Task 1). The nine technical project tasks were pursued by separate research teams at the University of Wyoming, but all nine tasks were coordinated to the extent possible in order to maximize information gained about CBNG co-produced waters. In addition to project management in Task 1, the key research tasks included: (2) estimating groundwater recharge rates in the PRB; (3

  14. Action Research as a Professional Development Activity

    Science.gov (United States)

    West, Chad

    2011-01-01

    Reflective teachers are always searching for ways to improve their teaching. When this reflection becomes intentional and systematic, they are engaging in teacher research. This type of research, sometimes called "action research", can help bridge the gap between theory and practice by addressing topics that are relevant to practicing teachers.…

  15. Brain gain | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-01-24

    Jan 24, 2011 ... IDRC research fellowship recipient, Fidelis Allen. ... the opportunity to stay in Africa and conduct research on a topic of vital regional interest. ... “A good many of the researchers we support, fortunately, have remained in Africa ...

  16. View all initiatives | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Initiative. The Cultivate Africa's Future research partnership is designed to support applied research to combat hunger in sub-Saharan Africa by harnessing the potential for innovation among the region's smallholder farmers, the majority of whom are women. We fund researchers driving global change. Careers · Contact Us ...

  17. Benin | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... the country's decision-makers tools to design policies to combat poverty. ... Our funding in agricultural research in Benin has helped improve small farm operations. ... climate change on food security and rural poverty; reduce urban air pollution, ... research capabilities at Benin's Institute for Empirical Research in Political ...

  18. Caribbean | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... we've supported the efforts of researchers in the English-speaking Caribbean. ... Languages ... Home · What we do · Regions and countries · Latin America and the ... We have funded research with a focus on trade and the economy, which ... IDRC-supported research broke new ground with one of the first analyses of ...

  19. New-laser research and development

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    Two new-laser research efforts were initiated during the reporting period; the chemically pumped iodine laser and HgXe exciplex excitation by electric discharge. The chemically pumped iodine laser was recently discovered by personnel at the Air Force Weapons Laboratory. The laser offers exciting possibilities as an ICF driver because it does not require a capital-intensive pulse power source to drive it, and up to 10% efficiency may be possible. Modeling studies of the laser are in progress and its potential as a high-average power laser seems to be very favorable at this time. The HgXe exciplex radiates in a band centered at 265 nm. This system is being studied because it could be used to pump an iodine laser. Its potential as a high-power laser candidate will be assessed. An advanced oscillator system based upon a microprocessor-controlled Nd:YAG-pumped pulsed dye laser is being developed so that it can be used as the front end of new laser-fusion lasers and utilized in testing and making germane laser amplifier measurements of candidate laser systems for the wavelength region of 4000 A to 8000 A and extended range with frequency doubling and mixing. The operating requirements of the oscillator system include long-term stability, high reliability, absolute wavelength calibration and control, tunability, hands-off operation, and variable pulse width generation in the nanosecond regime

  20. Challenges of Research and Human Capital Development in Nigeria

    Science.gov (United States)

    Chikwe, Christian K.; Ogidi, Reuben C.; Nwachukwu, K.

    2015-01-01

    The paper discussed the challenges of research and human capital development in Nigeria. Research and human capital development are critical to the development of any nation. Research facilitates human capital development. A high rating in human capital development indices places a country among the leading countries of the world. The paper…

  1. Energy research and development in Denmark

    Energy Technology Data Exchange (ETDEWEB)

    Hultberg, S.; Lindstroem Thomsen, P.

    1996-06-01

    The document describes some of the most important results produced during the last twenty years under the Danish government`s Energy Research Programme (ERP). Some of the involved research groups, and their current research projects, are described. The aim is to invite international cooperation on research in this field. Research areas are divided under the main headings of energy policy, energy supply and energy end-use. The document is illustrated with coloured photographs, diagrams and graphs. The names of contact persons, firms and institutions relevant to the described projects are listed. (AB)

  2. Three essays on research and development

    Science.gov (United States)

    Sanyal, Paroma

    The impact of institutional changes and market structure on research and development (R&D) and technical progress is controversial. My dissertation investigates the determinants of R&D in the context of institutional change. The first two papers address the impact of deregulation in the US electric utility industry on R&D. The third paper investigates the linkage between patenting and different funding sources and patent office attributes. The first paper, "Deregulation, Restructuring and Changing R&D Paradigms in the US Electric Utility Industry", investigates the linkage between market structures and the conduct of R&D in the US electric utility industry. The primary finding of this paper is that institutional and competition factors interact in a way that suggest that the occurrence of full deregulation, coupled with effective retail competition in the market may mitigate the problem of declining R&D expenditures in the face of deregulation. The second paper, "Powering a Green Progress: Environmental Research in the Absence of Regulatory Oversight" analyzes the impact of changing market structure on environmental R&D expenditures by IOUs in the electric utility industry. Conventional wisdom holds that increased competition would lead firms to cut back on R&D funds directed towards social goals, such as the environment. But these arguments fail to take account the threat of future environmental regulations and its influence on disciplining firms. Theory and empirical results from this paper suggest that under certain conditions, even with high monitoring costs, an environmental regulatory agency's threat of stricter future regulations will successfully stem the decrease in environmental R&D expenditures. My third paper, "Birth of a Patent: the Role of Parents, Nursemaids and Constraints", presents an integrated theoretical and empirical approach that models the effects of different sources of R&D funding and patent office attributes on the patenting process. The

  3. NNSA Laboratory Directed Research and Development Program 2008 Symposium--Focus on Energy Security

    Energy Technology Data Exchange (ETDEWEB)

    Kotta, P R; Sketchley, J A

    2008-08-20

    sequestration, energy efficiency, and other energy security research projects that are being conducted under the LDRD Program at the DOE/NNSA national laboratories and under the Site Directed Research and Development Program (SDRD) at the Nevada Test Site. Speakers from DOE/NNSA, other federal agencies, the NNSA laboratories, and the private sector will provide their insights into the national security implications of emerging energy and environmental issues, and the LDRD investments in energy security at the national laboratories. Please take this opportunity to reflect upon the science and engineering needs of our country's energy demands, including those issues posed by climate change, paying attention to the innovative contributions that LDRD is providing to the nation.

  4. 7 CFR 906.37 - Research and development.

    Science.gov (United States)

    2010-01-01

    ... establishment of marketing research and development projects, including paid advertising, designed to assist... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 906.37 Section 906.37... LOWER RIO GRANDE VALLEY IN TEXAS Order Regulating Handling Research and Development § 906.37 Research...

  5. Site directed recombination

    Science.gov (United States)

    Jurka, Jerzy W.

    1997-01-01

    Enhanced homologous recombination is obtained by employing a consensus sequence which has been found to be associated with integration of repeat sequences, such as Alu and ID. The consensus sequence or sequence having a single transition mutation determines one site of a double break which allows for high efficiency of integration at the site. By introducing single or double stranded DNA having the consensus sequence flanking region joined to a sequence of interest, one can reproducibly direct integration of the sequence of interest at one or a limited number of sites. In this way, specific sites can be identified and homologous recombination achieved at the site by employing a second flanking sequence associated with a sequence proximal to the 3'-nick.

  6. Publications | Page 95 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 941 - 950 of 6374 ... Resilient poultry management for women in Kenya. Research shows that indigenous chicken are a strategic component of building resilience in semi-arid Kenya. Kenyan and Canadian experts and a network of hundreds of farmer groups improved poultry management as part of research to adapt ...

  7. Publications | Page 31 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 301 - 310 of 6375 ... From joining the global effort against Ebola to finding smart ways to adapt to a changing climate. How passion, commitment, and research are transforming maternal and child health worldwide. Five IDRC-supported health systems researchers talk about how their work is improving primary health ...

  8. Bulletin #119 | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    2017-05-29

    May 29, 2017 ... Our long-term partners from Rimisp presented their research and policy findings about the ongoing transformation of rural Latin America in an engaging public seminar. WATCH THE ... Funding of research in and on violently divided societies has increased over the past two decades. This book offers ways ...

  9. Gender | Page 16 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    In 2017, 29 teams and their 143 researchers joined the growing ranks of grantees benefiting from the career-building support of the Partnership for Economic Policy (PEP). The research projects, to be carried out in 22 countries, emerged from a rigorous selection process that began with 420 applicants responding to several ...

  10. Search | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Social exclusion, poor economic opportunities, restrictive gender roles, and lack of access to basic services for certain groups are some of the main factors ... Canadian International Food Security Research Fund | IDRC ... The Canadian International Food Security Research Fund (CIFSRF) invests in scaling up solutions that ...

  11. Ghana | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Our funds sponsored Ghana Health Service research to improve the country's ... Major reforms extended health care to the aged, the poor, and children under 18. ... Researchers in Ghana found innovative ways to use information technology to ... enhance the quality of climate change science at the University of Ghana ...

  12. Egypt | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Our research support in Egypt has shifted focus with the country's changing needs. ... With support from IDRC and other partners, the university established the Alexandria Research Centre for ... stimulate technology start ups; prepare youth for in high-demand jobs in retail, hospitality, ... Careers · Contact Us · Site map.

  13. Federico Burone | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Federico Burone is Regional Director, Latin America and the Caribbean, in Montevideo, Uruguay. He joined IDRC as Executive Director of the Environmental Management Secretariat. He previously worked as Senior Researcher for the European Commission's DG XII Project and Research Assistant for the Industrial ...

  14. Publications | Page 84 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 831 - 840 of 7327 ... Through books, articles, research publications, and studies, we ... Explore outputs from more than four decades of IDRC-supported research. ... the correlation of losses across regions, instead of only focusing on ... In rural areas, equity gaps remain high reflecting unequal distribution of services.

  15. Stories | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Research findings are catalyst to nationwide HIV prevention trial in Botswana. New research into HIV prevention has led to a groundbreaking national trial for HIV prevention in Botswana. Selam Asre, 28, gave birth to a baby girl by Caesarean section at the ...

  16. Tanzania | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    We have a rich history of supporting research in Tanzania, a politically stable democracy. ... importance of improving health and agriculture in order to reduce poverty. ... For more than a decade, we have provided grants that foster the capacity to ... fellowships and foster links between researchers and institutions in Tanzania ...

  17. Motivating Scientific Research and Development: | Ononogbu | Bio ...

    African Journals Online (AJOL)

    Scientific research is an important aspect of the function of a university lecturer. It is how he/she carries out this function that determines his/her relevance in the university system and indeed in the scientific community as a whole. Scientific research or investigation may be divided into four sections: mental exercise, ...

  18. Search Results | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 1 - 10 of 8518 ... Giving girls and women the power to decide. Addressing Africa's unmet need for family planning by intensifying sexual and reproductive and adolescent health research. Research in Action. Health MATERNAL AND CHILD HEALTH ADOLESCENT HEALTH FAMILY PLANNING ...

  19. Publications | Page 42 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 411 - 420 of 6341 ... ... and offer free training materials to guide researchers and institutions. ... Use this search tool to locate a specific publication for your field of research. ... barricaded roads using stones and tree trunks to prevent the ...

  20. Publications | Page 68 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 671 - 680 of 6374 ... ... and offer free training materials to guide researchers and institutions. ... Use this search tool to locate a specific publication for your field of research. ... olifera) Kitir (Acacia mellifera) trees and palatable range spp as ...

  1. Publications | Page 30 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 291 - 300 of 6341 ... We share the results of our funded research, and offer free training materials to guide researchers and institutions. ... Use this search tool to locate a specific publication for your field ... Pakistan: A different way to plant.

  2. Gender | Page 178 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Gender. Sexospécificités. Co-founder Rebecca Chiao on her speaking tour of Canada ... As the world observes World Health Day on April 7, IDRC asked researchers: ... Researchers supported by IDRC focus on the root causes of inequities and ... with high and/or growing inequalities, and inequality can hamper growth.

  3. The network evolves | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-07-08

    Jul 8, 2011 ... For the 19 young scholars brought together by the Poverty Research Network, the rewards have been substantial. Lu Ming, who describes his experience with the group as “just fantastic,” likens the network to a bridge – connecting China to Canada, and linking researchers to each other and to scholars ...

  4. Developments in the regulation of research reactors

    International Nuclear Information System (INIS)

    Loy, J.

    2003-01-01

    The International Atomic Energy Agency (IAEA) has data on over 670 research reactors in the world. Fewer than half of them are operational and a significant number are in a shutdown but not decommissioned state. The International Nuclear Safety Advisory Group (INSAG) has expressed concerns about the safety of many research reactors and this has resulted in a process to draw up an international Code of Conduct on the Safety of Research Reactors. The IAEA is also reviewing its safety standards applying to research reactors. On the home front, regulation of the construction of the Replacement Research Reactor continues. During the construction phase, regulation has centred around the consideration of Requests for Approval (RFA) for the manufacture and installation of systems, structures and components important for safety. Quality control of construction of systems, structures and components is the central issue. The process for regulation of commissioning is under consideration

  5. Changing the inhibitory specificity and function of Cucurbita maxima trypsin inhibitor-V by site-directed mutagenesis.

    Science.gov (United States)

    Wen, L; Lee, I; Chen, G; Huang, J K; Gong, Y; Krishnamoorthi, R

    1995-02-27

    Cucurbita maxima trypsin inhibitor-V (CMTI-V) is also a specific inhibitor of human blood coagulation factor beta-factor XIIa. A recombinant version of CMTI-V has allowed probing of roles of individual amino acid residues including the reactive site residue, lysine (P1), by site-directed mutagenesis. The K44R showed at least a 5-fold increase in inhibitory activity toward human beta-factor XIIa, while there was no change toward bovine trypsin. This result demonstrates that beta-factor-XIIa prefers an arginine residue over lysine residue, while trypsin is non-specific to lysine or arginine in its binding pocket. On the other hand, the specificity of CMTI-V could be changed from trypsin to chymotrypsin inhibition by mutation of the P1 residue to either leucine or methionine (K44L or K44M).

  6. HTP-OligoDesigner: An Online Primer Design Tool for High-Throughput Gene Cloning and Site-Directed Mutagenesis.

    Science.gov (United States)

    Camilo, Cesar M; Lima, Gustavo M A; Maluf, Fernando V; Guido, Rafael V C; Polikarpov, Igor

    2016-01-01

    Following burgeoning genomic and transcriptomic sequencing data, biochemical and molecular biology groups worldwide are implementing high-throughput cloning and mutagenesis facilities in order to obtain a large number of soluble proteins for structural and functional characterization. Since manual primer design can be a time-consuming and error-generating step, particularly when working with hundreds of targets, the automation of primer design process becomes highly desirable. HTP-OligoDesigner was created to provide the scientific community with a simple and intuitive online primer design tool for both laboratory-scale and high-throughput projects of sequence-independent gene cloning and site-directed mutagenesis and a Tm calculator for quick queries.

  7. Site-directed mutagenesis of Azotobacter vinelandii ferredoxin I: [Fe-S] cluster-driven protein rearrangement

    International Nuclear Information System (INIS)

    Martin, A.E.; Burgess, B.K.; Stout, C.D.; Cash, V.L.; Dean, D.R.; Jensen, G.M.; Stephens, P.J.

    1990-01-01

    Azotobacter vinelandii ferredoxin I is a small protein that contains one [4Fe-4S] cluster and one [3Fe-4S] cluster. Recently the x-ray crystal structure has been redetermined and the fdxA gene, which encodes the protein, has been cloned and sequenced. Here the authors report the site-directed mutation of Cys-20, which is a ligand of the [4Fe-4S] cluster in the native protein, to alanine and the characterization of the protein product by x-ray crystallographic and spectroscopic methods. The data show that the mutant protein again contains one [4Fe-4S] cluster and one [3Fe-4S] cluster. The new [4Fe-4S] cluster obtains its fourth ligand from Cys-24, a free cysteine in the native structure. The formation of this [4Fe-4S] cluster drives rearrangement of the protein structure

  8. Enhancement of thermostability and kinetic efficiency of Aspergillus niger PhyA phytase by site-directed mutagenesis.

    Science.gov (United States)

    Hesampour, Ardeshir; Siadat, Seyed Ehsan Ranaei; Malboobi, Mohammad Ali; Mohandesi, Nooshin; Arab, Seyed Shahriar; Ghahremanpour, Mohammad Mehdi

    2015-03-01

    Phytase efficiently catalyzes the hydrolysis of phytate to phosphate; it can be utilized as an animal supplement to provide animals their nutrient requirements for phosphate and to mitigate environmental pollution caused by unutilized feed phosphate. Owing to animal feed being commonly pelleted at 70 to 90 °C, phytase with a sufficiently high thermal stability is desirable. Based on the crystal structure of PhyA and bioinformatics analysis at variant heat treatments, 12 single and multiple mutants were introduced by site-directed mutagenesis in order to improve phytase thermostability. Mutated constructs were expressed in Pichia pastoris. The manipulated phytases were purified; their biochemical and kinetic investigation revealed that while the thermostability of six mutants was improved, P9 (T314S Q315R V62N) and P12 (S205N S206A T151A T314S Q315R) showed the highest heat stability (P phytase to be used as an animal feed supplement.

  9. Outlook on Research in Education for Sustainable Development

    Science.gov (United States)

    Grasel, Cornelia; Bormann, Inka; Schutte, Kerstin; Trempler, Kati; Fischbach, Robert

    2013-01-01

    This article provides an overview of current research on Education for Sustainable Development (ESD). It shows a lack of correspondence between ESD research and recent debates in educational research. Research on ESD has established as a field of research with insufficient relations to other fields in educational research. Based on the overview…

  10. Elucidating the design principles of photosynthetic electron-transfer proteins by site-directed spin labeling EPR spectroscopy.

    Science.gov (United States)

    Ishara Silva, K; Jagannathan, Bharat; Golbeck, John H; Lakshmi, K V

    2016-05-01

    Site-directed spin labeling electron paramagnetic resonance (SDSL EPR) spectroscopy is a powerful tool to determine solvent accessibility, side-chain dynamics, and inter-spin distances at specific sites in biological macromolecules. This information provides important insights into the structure and dynamics of both natural and designed proteins and protein complexes. Here, we discuss the application of SDSL EPR spectroscopy in probing the charge-transfer cofactors in photosynthetic reaction centers (RC) such as photosystem I (PSI) and the bacterial reaction center (bRC). Photosynthetic RCs are large multi-subunit proteins (molecular weight≥300 kDa) that perform light-driven charge transfer reactions in photosynthesis. These reactions are carried out by cofactors that are paramagnetic in one of their oxidation states. This renders the RCs unsuitable for conventional nuclear magnetic resonance spectroscopy investigations. However, the presence of native paramagnetic centers and the ability to covalently attach site-directed spin labels in RCs makes them ideally suited for the application of SDSL EPR spectroscopy. The paramagnetic centers serve as probes of conformational changes, dynamics of subunit assembly, and the relative motion of cofactors and peptide subunits. In this review, we describe novel applications of SDSL EPR spectroscopy for elucidating the effects of local structure and dynamics on the electron-transfer cofactors of photosynthetic RCs. Because SDSL EPR Spectroscopy is uniquely suited to provide dynamic information on protein motion, it is a particularly useful method in the engineering and analysis of designed electron transfer proteins and protein networks. This article is part of a Special Issue entitled Biodesign for Bioenergetics--the design and engineering of electronic transfer cofactors, proteins and protein networks, edited by Ronald L. Koder and J.L. Ross Anderson. Copyright © 2016. Published by Elsevier B.V.

  11. Enhancement of oxidative stability of the subtilisin nattokinase by site-directed mutagenesis expressed in Escherichia coli.

    Science.gov (United States)

    Weng, MeiZhi; Zheng, ZhongLiang; Bao, Wei; Cai, YongJun; Yin, Yan; Zou, GuoLin; Zou, GouLin

    2009-11-01

    Nattokinase (subtilisin NAT, NK) is a bacterial serine protease with strong fibrinolytic activity and it is a potent cardiovascular drug. In medical and commercial applications, however, it is susceptible to chemical oxidation, and subsequent inactivation or denaturation. Here we show that the oxidative stability of NK was substantially increased by optimizing the amino acid residues Thr(220) and Met(222), which were in the vicinity of the catalytic residue Ser(221) of the enzyme. Two nonoxidative amino acids (Ser and Ala) were introduced at these sites using site-directed mutagenesis. Active enzymes were successfully expressed in Escherichia coli with periplasmic secretion and enzymes were purified to homogeneity. The purified enzymes were analyzed with respect to oxidative stability, kinetic parameters, fibrinolytic activity and thermal stability. M222A mutant was found to have a greatly increased oxidative stability compared with wild-type enzyme and it was resistant to inactivation by more than 1 M H(2)O(2), whereas the wild-type enzyme was inactivated by 0.1 M H(2)O(2) (t(1/2) approximately 11.6 min). The other mutant (T220S) also showed an obvious increase in antioxidative ability. Molecular dynamic simulations on wild-type and T220S mutant proteins suggested that a hydrogen bond was formed between Ser(220) and Asn(155), and the spatial structure of Met(222) was changed compared with the wild-type. The present study demonstrates the feasibility of improving oxidative stability of NK by site-directed mutagenesis and shows successful protein engineering cases to improve stability of NK as a potent therapeutic agent.

  12. Developing Capacity for Agricultural Research for Development in ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This project will train a new group of agricultural research leaders in Francophone West and Central Africa. The number of agricultural scientists in the region has fallen at a time when high-quality research is needed to improve food security and livelihoods. Training and research opportunities A total of 20 training and ...

  13. Exploratory Research and Development Fund, FY 1990

    International Nuclear Information System (INIS)

    1992-05-01

    The Lawrence Berkeley Laboratory Exploratory R ampersand D Fund FY 1990 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the projects supported and summarizes their accomplishments. It constitutes a part of an Exploratory R ampersand D Fund (ERF) planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The research areas covered in this report are: Accelerator and fusion research; applied science; cell and molecular biology; chemical biodynamics; chemical sciences; earth sciences; engineering; information and computing sciences; materials sciences; nuclear science; physics and research medicine and radiation biophysics

  14. Exploratory Research and Development Fund, FY 1990

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-01

    The Lawrence Berkeley Laboratory Exploratory R D Fund FY 1990 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the projects supported and summarizes their accomplishments. It constitutes a part of an Exploratory R D Fund (ERF) planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The research areas covered in this report are: Accelerator and fusion research; applied science; cell and molecular biology; chemical biodynamics; chemical sciences; earth sciences; engineering; information and computing sciences; materials sciences; nuclear science; physics and research medicine and radiation biophysics.

  15. Economics | Page 21 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... in our globalizing world, major natural resource developments are spreading to more ... current beliefs about good practice in the provision of business development ... for their livelihoods — on farmland or forests, wetlands or coastal areas.

  16. Gender | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Asian Development Bank ... Women and children riding the Lahore Bus Rapid Transit ( Lahore Metro Bus) service. ... of economic growth for developing countries, they are also frequently the site of growing violence, poverty, and inequality.

  17. About IDRC | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... to promote growth, reduce poverty, and drive large-scale positive change. ... Working with our development partners, we multiply the impact of our ... We offer fellowships and awards to nurture a new generation of development leaders.

  18. Gender | Page 171 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    As an engine of economic growth, private enterprise plays an important role in ... In helping developing countries pursue private sector development strategies that ... supported by IDRC is laying the groundwork for more inclusive growth.

  19. Research Note Development and characterization of microsatellite ...

    Indian Academy of Sciences (India)

    Srirama R

    provide important information in developing sustainable harvesting practices. .... United States Agency for International Development (USAID, Award number: ... Rozen S., Skaletsky H. 2000 Primer3 on the WWW for general users and for ...

  20. Publications | Page 13 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 121 - 130 of 7330 ... ... researchers and institutions to build local capacity through funding, knowledge sharing, and training. ... In almost all countries, women are less likely to be employed than men, and typically earn less than men.

  1. Bangladesh | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Another example is a large-scale research project examining how people can best ... participation in the workforce, and to women's entrepreneurial success. ... in local think tanks; lower the rate of child marriages in poor urban settlements ...

  2. Publications | Page 20 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 191 - 200 of 6341 ... ... and offer free training materials to guide researchers and institutions. ... Improving citizen awareness and democratic elections in Peru ... Africa has achieved impressive economic growth in the past 15 years; from ...

  3. Publications | Page 23 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 221 - 230 of 7327 ... ... and offer free training materials to guide researchers and institutions. ... Improving citizen awareness and democratic elections in Peru ... Africa has achieved impressive economic growth in the past 15 years; from ...

  4. Publications | Page 87 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 861 - 870 of 7331 ... ... offer free training materials to guide researchers and institutions. ... Collecting state : a study about Argentina and citizens' personal data (open access) ... Cambodia's preparedness for ASEAN economic community ...

  5. The Importance of Research in Developing Countries

    African Journals Online (AJOL)

    ies of workers required for an engineering project. These are:- .... geophysics and siesmology, mining and economic geo!ogy, volcanology ... planning of scientific research and the establishment of ... the execution of the work. The 'Pugwash' ...

  6. Publications | Page 10 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 91 - 100 of 6374 ... ... crime mask the many ways in which residents experience violence in their daily lives. ... radically improve living conditions for the country's black majority remain unmet. ... Why does research excellence matter?

  7. Publications | Page 85 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 841 - 850 of 6342 ... ... researchers, and faculty to Canadian educational institutions, and their ... Artisanal and small-scale gold mining (ASGM) is the largest source ... city of Buenos Aires, Open Government Data initiative (open access) ...

  8. Publications | Page 80 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 791 - 800 of 7174 ... This research seeks to understand the open data initiative on national ... through innovative educational strategies and sustainable agriculture. ... Final technical report : management and stabilization of mining and ...

  9. Search Results | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 1 - 10 of 8533 ... Research findings illustrate how environmental degradation and insecure ... Healing and resilience in situations of conflict and displacement ... Rapid global urbanization presents important social, environmental, and ...

  10. IT Security Specialist | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The IT Security Specialist takes a strategic role in the delivery of Infrastructure ... on IT Security to project managers, business clients and senior management. ... as a team member or a team leader by undertaking research, investigations, ...

  11. Helen Mendes | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    I think my health-related stories have made the greatest impact. ... find stories about local research, which has a greater impact on the lives of people here. ... Understanding the algorithms that rule news distribution on social media also helps.

  12. Publications | Page 60 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 591 - 600 of 6341 ... Through books, articles, research publications, and studies, we aim to ... Home · Resources ... Climate change will affect water availability in Chile, Colombia, and Bolivia, in the three basins this project is studying.

  13. Publications | Page 58 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 571 - 580 of 6381 ... Through books, articles, research publications, and studies, we aim to ... Home · Resources ... Climate change will affect water availability in Chile, Colombia, and Bolivia, in the three basins this project is studying.

  14. Infectious diseases | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-12-13

    Dec 13, 2010 ... Ecohealth Works: Health in Urban Environments ... To respond to this complexity, researchers from many disciplines need to work collaboratively with ... the house, where they fed on animals at a safe distance from people.

  15. One scholar's story | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-07-08

    Jul 8, 2011 ... ... in China, with enormous regional differences and rural-urban dualism, and ... Lu Ming credits the Poverty Research Network with playing a part in his ... CASE STUDY: Nepal — A cleaner city and better health in Kathmandu.

  16. Publications | Page 61 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 601 - 610 of 6334 ... ... Information and Communication, Natural Resources, Gender ... organizations can overcome violence, inequality, and poverty. Barolsky leads a project. ... the use of research in disaster risk management in India.

  17. Books | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Book cover: Social Theories of Urban Violence in the Global South ... together the experiences and lessons learned from five civil society organizations (CSOs) ... Research Capacity in Healthcare Systems: Case Studies and Innovative Models.

  18. Contact Us | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Mobile Nav Footer Links. Careers · Contact Us · Subscribe · Unsubscribe · Copyright · Open Access Policy · Privacy Policy · Research Ethics · Transparency · Website/Usage. Search. Home · About IDRC ...

  19. Publications | Page 19 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 181 - 190 of 6381 ... Through books, articles, research publications, and studies, we aim to widen the impact of our ... Journal articles ... 'Child labor in Myanmar's Garment Sector' report by Business for Social Responsibility (BSR).

  20. Vietnam | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... of its success, local fishery associations secured fishing management rights in 2009, a first in Vietnam. ... We continue to support online education through regional research to improve the quality of distance education. Total IDRC Support ...

  1. Publications | Page 87 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 861 - 870 of 7331 ... Using social network analysis to profile organised crime (restricted access) ... and to maximize delivery of equitable economic benefits of research. ... and Child Care (MHCC) & Micro, Small, and Medium Enterprises ...

  2. Publications | Page 49 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 481 - 490 of 6381 ... Conventional risk aversion measures often do not fully explain decision behavior; ... Training young researchers to influence telecommunications ... Public Access ICT across Cultures: Diversifying Participation in the ...

  3. Publications | Page 57 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 561 - 570 of 6341 ... Highlight: Kenya selects first research chair on health systems ... in Vietnam with crucial information about pregnancy, birth, and infant care. ... An agriculture, food security, and nutrition expert based in Cambodia, ...

  4. Canada's International Development Research Centre (IDRC) is ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    irocca

    programs, and practices, but in the daily work and actions of our employees. ... As a research institution dedicated to ethical practices and scientific excellence, it .... We are responsible for ensuring that purchasing and funding decisions are ...

  5. Making waves | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-01-26

    Jan 26, 2011 ... However, in 1990 there were no models for how information and ... Computers, the Internet, mobile phones, interactive CD-ROMs, newspapers, the radio ... The research: Creative technological fixes and social innovations.

  6. Haiti | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... for the environment, reduced spending on food, increased self-esteem, and stronger ... The consortium acts as a knowledge centre and explores communication ... train teachers and researchers in high-quality science and technology skills ...

  7. Gender | Page 190 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... chronic water shortages in the agricultural areas that support 80% of the population. ... Madagascar, the world's fourth largest island, is home to an astonishing ... well-researched book examines the challenges to private sector growth in 12 ...

  8. Publications | Page 68 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 671 - 680 of 6381 ... Through books, articles, research publications, and studies, we ... Journal articles ... Obesogenic environments : access to and advertising of sugar-sweetened beverages in Soweto, South Africa, 2013 (open access).

  9. Brazil | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC-supported research in Brazil has informed policy debates on a variety of issues, including democracy, economic growth, health, social services, innovation, ... earthquake, including food security and public-private sector partnerships.

  10. Information Technology Research & Development Foresight in Iran.

    Directory of Open Access Journals (Sweden)

    Mansoor Sheydaee

    2017-09-01

    The results of the Delphi process was reported in national level, including Delphi panel members demography, public questions and specialized questions for each of the technologies. Finally the research provides some recommendations for decision makers.

  11. Publications | Page 61 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 601 - 610 of 6345 ... Through books, articles, research publications, and studies, we aim to widen the ... Journal articles. Papers. Reports. Studies. Training materials ... Highlight: Ankara workshop puts minimum wage on the G-20 radar.

  12. Gender | Page 179 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... et font connaître des solutions pratiques pour la culture des légumineuses à ... Language French ... Language French ... Language French ... Language French ... A project supported by the Canadian International Food Security Research ...

  13. Argentina | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... the municipal government in Buenos Aires improved its ability to control the spread of ... The research has created the conditions for future economic activity and jobs, ... increase quality maternal health care for indigenous women; promote ...

  14. Publications | Page 98 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 971 - 980 of 6381 ... Through books, articles, research publications, and studies, we aim to ... Globalization, population growth and climate change are some new factors ... that households have a more diversified, higher-protein diet.

  15. Publications | Page 13 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-10-07

    Results 121 - 130 of 6341 ... Exploring non-violent male identities ... In this 2014 profile, researchers with the Tata Institute of Social Sciences ... At an October 7, 2016 project launch, prominent advocates from the Women's Learning Partnership ...

  16. Burkina Faso | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    We have also enabled researchers to create an online justice system database so ... It led to better harvesting, processing, and marketing techniques, as well as ... institute a university master's program in health systems and policy analysis ...

  17. Jordan | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results included improved farming practices for chickpeas and lentils, and better ... to treat greywater — wastewater collected from laundry tubs, sinks, and showers. ... Research has helped households safely irrigate crops such as olives and ...

  18. Publications | Page 83 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 821 - 830 of 7327 ... ... most relevant global grain suppliers of South America, the fast expansion of crops over pastures (Pampas... Making Evaluation Matter: Writings from South Asia ... Research improves secure access to nutritious food.

  19. Florencia Ballarino | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    I am particularly interested in medicine and scientific advances in this field. ... The main challenge is to build bridges between the scientific community and society. ... a country progresses if it is not through scientific and technological research.

  20. IDRC Book Panel | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-11-02

    Nov 2, 2010 ... It requires scientists to work across disciplines, to engage communities ... Improving health, food security and soil fertility in Malawi ... Minu Sharma, National Zoonoses and Food Hygiene Research Centre Kathmandu, Nepal.

  1. Publications | Page 83 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 821 - 830 of 6357 ... We share the results of our funded research, and offer free training ... This paper examines protection racketeering in Cape Town, primarily in the ... sample lesson plans are provided for primary school aged children ...

  2. Veterinary Research Manpower Development for Defense

    Science.gov (United States)

    2009-09-01

    Wilson V’11 Mentor: Dr. Jon Epstein Research Project: Infectious Risks of Brushmeat Hunting on Malaysia Summary: This is a...restaurant workers who are shooting, butchering and cooking wildlife as part of the bushmeat trade in Peninsular Malaysia . During the course of this...activities, diet , housing and interaction (with other elephants, livestock and wildlife). Research into the risk factors associated with the transmission

  3. Operational Research(ers in development: Growing a new generation of operational researchers

    Directory of Open Access Journals (Sweden)

    I Durbach

    2013-06-01

    Full Text Available This paper explores the theme of training operational research (OR practitioners in South Africa by critically evaluating a Masters program in Operational Research in Development (ORD, launched in 2005 at the University of Cape Town. This program was specifically focused on applying OR to the problems of the developing world in general and Africa in particular. We describe the program and review the practical work undertaken by students participating in the program. Topics range widely across domains including health (antimalarial drug resistance; poverty (food banking; governance (NGO management structures and monitoring of local government performance and sustainable livelihoods (spaza shop operations. We use the review to highlight strengths and weaknesses of the program, as well as challenges faced in the OR education in South Africa at a postgraduate level.

  4. Energy Research and Development at Kuwait Institute for Scientific Research

    Energy Technology Data Exchange (ETDEWEB)

    Debs, A. S.

    1980-07-01

    The Kuwait program encompasses five complimentary areas. These are: the energy data base and technology assessment program, the energy conservation program, the electric power program, the solar energy program, and the energy policy analysis program. The accomplishments up until 1980 of the energy activities at KISR include activities in the solar cooling area, solar electric power generation, solar water desalinatin, and in solar agriculture applications. Furthermore there were some activities in the energy conservation area with emphasis on the use of insulating materials and the thermal response of buildings for energy conservation in the building sector. At present major project activities concentrate on energy conservation with emphasis on the development of an energy building code for Kuwait and an experimental and theoretical evaluation of various energy conservation alternatives for Kuwaiti buildings. In the solar area the emphasis will continue to be in the solar cooling area with possible introduction of Rankine Cycle Cooling as a more viable alternative to absorption cooling than has been experienced so far.

  5. What we do | Page 76 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    providing developing-country researchers with financial resources, advice, and ... Canadian researchers analyzing the causes of food insecurity in India and the ... and economic inclusion in developing countries poses particular challenges for ...

  6. 2016 Federal Cybersecurity Research and Development Strategic Plan

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — As part of the Presidents Cybersecurity National Action Plan (CNAP), the Administration released the 2016 Federal Cybersecurity Research and Development Strategic...

  7. 48 CFR 970.35 - Research and development contracting.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Research and development... SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Major System Acquisition 970.35 Research and development contracting. ...

  8. The Research and Development of COM-PLY Lumber

    Science.gov (United States)

    Robert H. McAlister

    1989-01-01

    Between 1974 and 1986, a Southeastern Station Research Work Unit developed standards for composite studs, joists, and truss lumber and manufactured and demonstrated the materials. Economic feasibility was considered in every stage of research. Further development is left to industry.

  9. Report on Implementing the Federal Cybersecurity Research and Development Strategy

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — In December 2011 the NSTC released Trustworthy Cyberspace: Strategic Plan for the Federal Cybersecurity Research and Development Program, outlining a vision for the...

  10. 77 FR 20377 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2012-04-04

    ... Biomass Research and Development Technical Advisory Committee under Section 9008(d) of the Food... DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy Biomass Research and Development Technical Advisory Committee AGENCY: Office of Energy Efficiency and Renewable Energy, Department...

  11. The Federal Big Data Research and Development Strategic Plan

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — Summary: This Plan is an important milestone in the Administrations Big Data Research and Development (R&D) Initiative

  12. Metal-air battery research and development

    Science.gov (United States)

    Behrin, E.; Cooper, J. F.

    1982-05-01

    This report summarizes the activities of the Metal-air Battery Program during the calendar year 1981. The principal objective is to develop a refuelable battery as an automotive energy source for general-purpose electric vehicles and to conduct engineering demonstrations of its ability to provide vehicles with the range, acceleration, and rapid refueling capability of current internal-combustion-engine automobiles. The second objective is to develop an electrically-rechargeable battery for specific-mission electric vehicles, such as commuter vehicles, that can provide low-cost transportation. The development progression is to: (1) develop a mechanically rechargeable aluminum-air power cell using model electrodes, (2) develop cost-effective anode and cathode materials and structures as required to achieve reliability and efficiency goals, and to establish the economic competitiveness of this technology, and (3) develop and integrated propulsion system utilizing the power cell.

  13. Fuel Fabrication Capability Research and Development Plan

    Energy Technology Data Exchange (ETDEWEB)

    Senor, David J.; Burkes, Douglas

    2014-04-17

    The purpose of this document is to provide a comprehensive review of the mission of the Fuel Fabrication Capability (FFC) within the Global Threat Reduction Initiative Convert Program, along with research and development (R&D) needs that have been identified as necessary to ensuring mission success. The design and fabrication of successful nuclear fuels must be closely linked endeavors. Therefore, the overriding motivation behind the FFC R&D program described in this plan is to foster closer integration between fuel design and fabrication to reduce programmatic risk. These motivating factors are all interrelated, and progress addressing one will aid understanding of the others. The FFC R&D needs fall into two principal categories, 1) baseline process optimization, to refine the existing fabrication technologies, and 2) manufacturing process alternatives, to evaluate new fabrication technologies that could provide improvements in quality, repeatability, material utilization, or cost. The FFC R&D Plan examines efforts currently under way in regard to coupon, foil, plate, and fuel element manufacturing, and provides recommendations for a number of R&D topics that are of high priority but not currently funded (i.e., knowledge gaps). The plan ties all FFC R&D efforts into a unified vision that supports the overall Convert Program schedule in general, and the fabrication schedule leading up to the MP-1 and FSP-1 irradiation experiments specifically. The fabrication technology decision gates and down-selection logic and schedules are tied to the schedule for fabricating the MP-1 fuel plates, which will provide the necessary data to make a final fuel fabrication process down-selection. Because of the short turnaround between MP-1 and the follow-on FSP-1 and MP-2 experiments, the suite of specimen types that will be available for MP-1 will be the same as those available for FSP-1 and MP-2. Therefore, the only opportunity to explore parameter space and alternative processing

  14. The Future of Asthma Research and Development

    DEFF Research Database (Denmark)

    Masefield, Sarah; Edwards, Jessica; Hansen, Kjeld S.

    2017-01-01

    A unified approach to innovation is needed to address the challenge of asthma in Europe. It is the opinion of the EARIP consortium and associated members (comprising most asthma networks, societies and professional groups) that if all of these research priority areas were funded and the 15 research...... questions addressed, asthma outcomes would be transformed and avoidable use of healthcare systems eradicated, resulting in significant financial savings. The realisation of this vision through coordinated efforts at a European level is the only way to achieve the change needed to reduce asthma deaths...

  15. Research development at a South African university of technology: A ...

    African Journals Online (AJOL)

    This article portrays the research development strategies followed by a University of Technology in an attempt to increase and sustain a research culture. It discusses the approach of research development through building structural and intellectual capacity amongst the existing population of researchers which includes, ...

  16. 7 CFR 905.54 - Marketing, research and development.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Marketing, research and development. 905.54 Section... Marketing, research and development. The committee may, with the approval of the Secretary, establish, or provide for the establishment of, projects including production research, marketing research and...

  17. 48 CFR 27.408 - Cosponsored research and development activities.

    Science.gov (United States)

    2010-10-01

    ....408 Cosponsored research and development activities. (a) In contracts involving cosponsored research... objectives of the contract. Since the purpose of the cosponsored research and development, the legitimate... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cosponsored research and...

  18. The Challenges of Developing Research Resources for Leading Vietnamese Universities

    Science.gov (United States)

    Nguyen, Thi Lan Huong

    2013-01-01

    This paper examines the challenges of developing research resources for leading Vietnamese universities. The first part of the paper presents the background to the study, including literature review on the challenges to research resources development, and describes the research questions and research methods. The next part provides empirical…

  19. Decontamination Technology Development for Nuclear Research Facilities

    International Nuclear Information System (INIS)

    Oh, Won Zin; Jung, Chong Hun; Choi, Wang Kyu; Won, Hui Jun; Kim, Gye Nam

    2004-02-01

    Technology development of surface decontamination in the uranium conversion facility before decommissioning, technology development of component decontamination in the uranium conversion facility after decommissioning, uranium sludge treatment technology development, radioactive waste soil decontamination technology development at the aim of the temporary storage soil of KAERI, Optimum fixation methodology derivation on the soil and uranium waste, and safety assessment methodology development of self disposal of the soil and uranium waste after decontamination have been performed in this study. The unique decontamination technology applicable to the component of the nuclear facility at room temperature was developed. Low concentration chemical decontamination technology which is very powerful so as to decrease the radioactivity of specimen surface under the self disposal level was developed. The component decontamination technology applicable to the nuclear facility after decommissioning by neutral salt electro-polishing was also developed. The volume of the sludge waste could be decreased over 80% by the sludge waste separation method by water. The electrosorption method on selective removal of U(VI) to 1 ppm of unrestricted release level using the uranium-containing lagoon sludge waste was tested and identified. Soil decontamination process and equipment which can reduce the soil volume over 90% were developed. A pilot size of soil decontamination equipment which will be used to development of real scale soil decontamination equipment was designed, fabricated and demonstrated. Optimized fixation methodology on soil and uranium sludge was derived from tests and evaluation of the results. Safety scenario and safety evaluation model were development on soil and uranium sludge aiming at self disposal after decontamination

  20. Competition, Regulation and Development Research Forum ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Many developing countries have adopted market-oriented reforms as a part of the globalization and liberalization process. However, due to market distortions, the need to ensure proper access to essential services requires effective regulation. Accordingly, developing countries are legislating or revising their ...