WorldWideScience

Sample records for site characterization tool

  1. ELT Site Characterization for AO, the Tools and the Results

    Science.gov (United States)

    Sarazin, M.

    2011-09-01

    With the choice of the sites of the three main ELT projects worldwide, an unprecedentedly large site characterization effort is coming to an end. During the past decade more than 20 summits have been studied by the site survey teams of E-ELT, GMT and TMT projects. Other institutions have provided support or funding (NOAO, EU-FP6) so that close to one hundred scientists, engineers and students have been involved in this search for top quality observing conditions. For the first time also, the various project have deployed a very uniform instrumentation suite, often using similar measurement methods (DIMM) and even in some cases identical instruments (MASS). The consequence is that the core of the collected database is directly usable and could be made available to the community in its original state. The various teams have also maintained close contact during the whole process and new instruments were developed on the fly to solve the remaining unknowns. After sharing the tools and ideas, the time of sharing data has come and a review is proposed of what has been achieved and what is now available.

  2. Expedited Site Characterization geophysics: Geophysical methods and tools for site characterization

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, N.E.

    1994-03-01

    This report covers five classes of geophysical technologies: Magnetics; Electrical/electromagnetic; Seismic reflection; Gamma-ray spectrometry; and Metal-specific spectrometry. Except for radiometry, no other classes of geophysical tedmologies are specific for direct detection of the types of contaminants present at the selected sites. For each of the five classes covered, the report gives a general description of the methodology, its field use, and its general applicability to the ESC Project. In addition, the report gives a sample of the most promising instruments available for each class, including the following information: Hardware/software attributes; Purchase and rental costs; Survey rate and operating costs; and Other applicable information based on case history and field evaluations.

  3. Sustainable Diagnostic Tools for Site Characterization and Remediation

    Science.gov (United States)

    Driver, E. M.; Roll, I. B.; Supowit, S. D.; Halden, R. U.

    2016-12-01

    Three submersible diagnostic tools were developed to enable more precise and cost-effective means of sampling environmental waters and assessing remedial strategies. The In Situ Sampler (IS2) and In Situ Sampler for Biphasic Water Monitoring (IS2B), designed for sampling groundwater or simultaneous pore- and surface water, use affordable off-the-shelf solid phase extraction technology, applicable to a broad range of organic and inorganic contaminants. Flow-through design reduces hazardous waste generation, transportation costs, and carbon footprint by 90-98% compared to traditional methods. The IS2 is ideal for dynamic groundwater systems where discrete sampling may fail to capture temporal variations, leading to inaccurate assessment of exposure and risk. A 28-day sampling event in a Cr(VI)-impacted aquifer captured previously undetected tidally-induced fluctuations, while improving the reporting limit 8-fold. The IS2B elucidates contaminant partitioning and bioavailability, and was validated in a wetland-shallow aquifer system with the pesticide fipronil. Concentrations of total fipronil-related compounds were statistically indistinguishable from those determined by conventional techniques (p > 0.2), ranging from 9.9 ± 4.6 to 18.1 ± 4.6 ng/L in surface water and 9.1 ± 3.0 to 12.6 ± 2.1 ng/L in porewater. For groundwater remedial testing, the In Situ Microcosm Array (ISMA) was developed to integrate laboratory column treatability studies with pilot-scale field-testing, thus minimizing costs associated with sequential lab and field analyses. In situ operation maintains (geo)chemical and microbial groundwater parameters often destroyed by extraction and laboratory storage. Onboard effluent capture permits the deployment well to return to monitoring status immediately after instrument removal. All tools employ reusable internal components and may be operated by solar power. Case study results highlight the capabilities and application range of the each technology.

  4. Stereoselectivity of supported alkene metathesis catalysts: a goal and a tool to characterize active sites

    Directory of Open Access Journals (Sweden)

    Christophe Copéret

    2011-01-01

    Full Text Available Stereoselectivity in alkene metathesis is a challenge and can be used as a tool to study active sites under working conditions. This review describes the stereochemical relevance and problems in alkene metathesis (kinetic vs. thermodynamic issues, the use of (E/Z ratio at low conversions as a tool to characterize active sites of heterogeneous catalysts and finally to propose strategies to improve catalysts based on the current state of the art.

  5. Immunological techniques as tools to characterize the subsurface microbial community at a trichloroethylene contaminated site

    Energy Technology Data Exchange (ETDEWEB)

    Fliermans, C.B.; Dougherty, J.M.; Franck, M.M.; McKinzey, P.C.; Hazen, T.C.

    1992-12-31

    Effective in situ bioremediation strategies require an understanding of the effects pollutants and remediation techniques have on subsurface microbial communities. Therefore, detailed characterization of a site`s microbial communities is important. Subsurface sediment borings and water samples were collected from a trichloroethylene (TCE) contaminated site, before and after horizontal well in situ air stripping and bioventing, as well as during methane injection for stimulation of methane-utilizing microorganisms. Subsamples were processed for heterotrophic plate counts, acridine orange direct counts (AODC), community diversity, direct fluorescent antibodies (DFA) enumeration for several nitrogen-transforming bacteria, and Biolog {reg_sign} evaluation of enzyme activity in collected water samples. Plate counts were higher in near-surface depths than in the vadose zone sediment samples. During the in situ air stripping and bioventing, counts increased at or near the saturated zone, remained elevated throughout the aquifer, but did not change significantly after the air stripping. Sporadic increases in plate counts at different depths as well as increased diversity appeared to be linked to differing lithologies. AODCs were orders of magnitude higher than plate counts and remained relatively constant with depth except for slight increases near the surface depths and the capillary fringe. Nitrogen-transforming bacteria, as measured by serospecific DFA, were greatly affected both by the in situ air stripping and the methane injection. Biolog{reg_sign} activity appeared to increase with subsurface stimulation both by air and methane. The complexity of subsurface systems makes the use of selective monitoring tools imperative.

  6. Immunological techniques as tools to characterize the subsurface microbial community at a trichloroethylene contaminated site

    Energy Technology Data Exchange (ETDEWEB)

    Fliermans, C.B.; Dougherty, J.M.; Franck, M.M.; McKinzey, P.C.; Hazen, T.C.

    1992-01-01

    Effective in situ bioremediation strategies require an understanding of the effects pollutants and remediation techniques have on subsurface microbial communities. Therefore, detailed characterization of a site's microbial communities is important. Subsurface sediment borings and water samples were collected from a trichloroethylene (TCE) contaminated site, before and after horizontal well in situ air stripping and bioventing, as well as during methane injection for stimulation of methane-utilizing microorganisms. Subsamples were processed for heterotrophic plate counts, acridine orange direct counts (AODC), community diversity, direct fluorescent antibodies (DFA) enumeration for several nitrogen-transforming bacteria, and Biolog [reg sign] evaluation of enzyme activity in collected water samples. Plate counts were higher in near-surface depths than in the vadose zone sediment samples. During the in situ air stripping and bioventing, counts increased at or near the saturated zone, remained elevated throughout the aquifer, but did not change significantly after the air stripping. Sporadic increases in plate counts at different depths as well as increased diversity appeared to be linked to differing lithologies. AODCs were orders of magnitude higher than plate counts and remained relatively constant with depth except for slight increases near the surface depths and the capillary fringe. Nitrogen-transforming bacteria, as measured by serospecific DFA, were greatly affected both by the in situ air stripping and the methane injection. Biolog[reg sign] activity appeared to increase with subsurface stimulation both by air and methane. The complexity of subsurface systems makes the use of selective monitoring tools imperative.

  7. SNL-NUMO collaborative : development of a deterministic site characterization tool using multi-model ranking and inference.

    Energy Technology Data Exchange (ETDEWEB)

    Grace, Matthew; Lowry, Thomas Stephen; Arnold, Bill Walter; James, Scott Carlton; Gray, Genetha Anne; Ahlmann, Michael

    2008-08-01

    Uncertainty in site characterization arises from a lack of data and knowledge about a site and includes uncertainty in the boundary conditions, uncertainty in the characteristics, location, and behavior of major features within an investigation area (e.g., major faults as barriers or conduits), uncertainty in the geologic structure, as well as differences in numerical implementation (e.g., 2-D versus 3-D, finite difference versus finite element, grid resolution, deterministic versus stochastic, etc.). Since the true condition at a site can never be known, selection of the best conceptual model is very difficult. In addition, limiting the understanding to a single conceptualization too early in the process, or before data can support that conceptualization, may lead to confidence in a characterization that is unwarranted as well as to data collection efforts and field investigations that are misdirected and/or redundant. Using a series of numerical modeling experiments, this project examined the application and use of information criteria within the site characterization process. The numerical experiments are based on models of varying complexity that were developed to represent one of two synthetically developed groundwater sites; (1) a fully hypothetical site that represented a complex, multi-layer, multi-faulted site, and (2) a site that was based on the Horonobe site in northern Japan. Each of the synthetic sites were modeled in detail to provide increasingly informative 'field' data over successive iterations to the representing numerical models. The representing numerical models were calibrated to the synthetic site data and then ranked and compared using several different information criteria approaches. Results show, that for the early phases of site characterization, low-parameterized models ranked highest while more complex models generally ranked lowest. In addition, predictive capabilities were also better with the low-parameterized models. For

  8. Site characterization handbook

    Energy Technology Data Exchange (ETDEWEB)

    1988-06-01

    This Handbook discusses both management and technical elements that should be considered in developing a comprehensive site characterization program. Management elements typical of any project of a comparable magnitude and complexity are combined with a discussion of strategies specific to site characterization. Information specific to the technical elements involved in site characterization is based on guidance published by the Nuclear Regulatory Commission (NRC) with respect to licensing requirements for LLW disposal facilities. The objective of this Handbook is to provide a reference for both NRC Agreement States and non-Agreement States for use in developing a comprehensive site characterization program that meets the specific objectives of the State and/or site developer/licensee. Each site characterization program will vary depending on the objectives, licensing requirements, schedules/budgets, physical characteristics of the site, proposed facility design, and the specific concerns raised by government agencies and the public. Therefore, the Handbook is not a prescriptive guide to site characterization. 18 refs., 6 figs.

  9. Site characterization techniques

    Science.gov (United States)

    ,

    1995-01-01

    Geoelectrical methods have been used since the 1920's to search for metallic ore deposits. During the last decade, traditional mining geophysical techniques have been adapted for environmental site characterization. Geoelectrical geophysics is now a well developed engineering specialty, with different methods to focus both on a range of targets and on depths below the surface. Most methods have also been adapted to borehole measurements.

  10. Site-Specific N-Glycosylation Characterization of Windmill Palm Tree Peroxidase Using Novel Tools for Analysis of Plant Glycopeptide Mass Spectrometry Data.

    Science.gov (United States)

    Baker, Margaret R; Tabb, David L; Ching, Travers; Zimmerman, Lisa J; Sakharov, Ivan Y; Li, Qing X

    2016-06-03

    Plant secretory (Class III) peroxidases are redox enzymes that rely on N-glycosylation for full enzyme activity and stability. Peroxidases from palm tree leaves comprise the most stable and active plant peroxidases characterized to date. Herein, site-specific glycosylation and microheterogeneity of windmill palm tree (Trachycarpus fortunei) peroxidase are reported. The workflow developed in this study includes novel tools, written in R, to aid plant glycan identification, pGlycoFilter, for annotation of glycopeptide fragmentation spectra, gPSMvalidator, and for relative quantitation of glycoforms, glycoRQ. Mass spectrometry analysis provided a detailed glycosylation profile at the 13 sites of N-linked glycosylation on windmill palm tree peroxidase. Glycan microheterogeneity was observed at each site. Site Asn211 was the most heterogeneous and contained 30 different glycans. Relative quantitation revealed 90% of each glycosylation site was occupied by three or fewer glycans, and two of the 13 sites were partially unoccupied. Although complex and hybrid glycans were identified, the majority of glycans were paucimannosidic, characteristic of plant vacuolar glycoproteins. Further studies pertaining to the glycan structure-activity relationships in plant peroxidases can benefit from the work outlined here.

  11. Characterization of novel SLC6A8 variants with the use of splice-site analysis tools and implementation of a newly developed LOVD database.

    Science.gov (United States)

    Betsalel, Ofir T; Rosenberg, Efraim H; Almeida, Ligia S; Kleefstra, Tjitske; Schwartz, Charles E; Valayannopoulos, Vassili; Abdul-Rahman, Omar; Poplawski, Nicola; Vilarinho, Laura; Wolf, Philipp; den Dunnen, Johan T; Jakobs, Cornelis; Salomons, Gajja S

    2011-01-01

    The X-linked creatine transporter defect is caused by mutations in the SLC6A8 gene. Until now, 66 synonymous and intronic variants in SLC6A8 were detected in our laboratory. To gain more insight in the effect of the detected variants, we applied five free web-based splice-site analysis tools to 25 published variants that were stratified as (non-)disease causing. All were correctly predicted to have no effect (n=18) or to cause erroneous splicing (n=7), with the exception of a pathogenic de novo 24 bp intronic deletion. Second, 41 unclassified variants, including 28 novel, were subjected to analysis by these tools. At least four splice-site analysis tools predicted that three of the variants would affect splicing as the mutations disrupted the canonical splice site. Urinary creatine/creatinine and brain MRS confirmed creatine transporter deficiency in five patients (four families), including one female. Another variant was predicted to moderately affect splicing by all five tools. However, transient transfection of a minigene containing the variant in a partial SLC6A8 segment showed no splicing errors, and thus was finally classified as non-disease causing. This study shows that splice tools are useful for the characterization of the majority of variants, but also illustrates that the actual effect can be misclassified in rare occasions. Therefore, further laboratory studies should be considered before final conclusions on the disease-causing nature are drawn. To provide an accessible database, the 109 currently known SLC6A8 variants, including 35 novel ones, are included in a newly developed LOVD DNA variation database.

  12. Characterization of novel SLC6A8 variants with the use of splice-site analysis tools and implementation of a newly developed LOVD database

    NARCIS (Netherlands)

    Betsalel, O.T.; Rosenberg, E.H.; Almeida, L.S.; Kleefstra, T.; Schwartz, C.E.; Valayannopoulos, V.; Abdul-Rahman, O.; Poplawski, N.; Vilarinho, L.; Wolf, P.; Dunnen, J.T. den; Jakobs, C.; Salomons, G.S.

    2011-01-01

    The X-linked creatine transporter defect is caused by mutations in the SLC6A8 gene. Until now, 66 synonymous and intronic variants in SLC6A8 were detected in our laboratory. To gain more insight in the effect of the detected variants, we applied five free web-based splice-site analysis tools to 25

  13. SNF Site Characterization Data: C.Jarvis

    Data.gov (United States)

    National Aeronautics and Space Administration — Site characterization parameters (canopy density, litter components, soil characterization: color, moisture, components) for selected sites within the Superior...

  14. SitesIdentify: a protein functional site prediction tool

    Directory of Open Access Journals (Sweden)

    Doig Andrew J

    2009-11-01

    Full Text Available Abstract Background The rate of protein structures being deposited in the Protein Data Bank surpasses the capacity to experimentally characterise them and therefore computational methods to analyse these structures have become increasingly important. Identifying the region of the protein most likely to be involved in function is useful in order to gain information about its potential role. There are many available approaches to predict functional site, but many are not made available via a publicly-accessible application. Results Here we present a functional site prediction tool (SitesIdentify, based on combining sequence conservation information with geometry-based cleft identification, that is freely available via a web-server. We have shown that SitesIdentify compares favourably to other functional site prediction tools in a comparison of seven methods on a non-redundant set of 237 enzymes with annotated active sites. Conclusion SitesIdentify is able to produce comparable accuracy in predicting functional sites to its closest available counterpart, but in addition achieves improved accuracy for proteins with few characterised homologues. SitesIdentify is available via a webserver at http://www.manchester.ac.uk/bioinformatics/sitesidentify/

  15. Social Networking Sites as a Learning Tool

    Science.gov (United States)

    Sanchez-Casado, Noelia; Cegarra Navarro, Juan Gabriel; Wensley, Anthony; Tomaseti-Solano, Eva

    2016-01-01

    Purpose: Over the past few years, social networking sites (SNSs) have become very useful for firms, allowing companies to manage the customer-brand relationships. In this context, SNSs can be considered as a learning tool because of the brand knowledge that customers develop from these relationships. Because of the fact that knowledge in…

  16. Preliminary Site Characterization Report, Rulsion Site, Colorado

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    This report is a summary of environmental information gathered during a review of the documents pertaining to Project Rulison and interviews with personnel who worked on the project. Project Rulison was part of Operation Plowshare (a program designed to explore peaceful uses for nuclear devices). The project consisted of detonating a 43-kiloton nuclear device on September 10, 1969, in western Colorado to stimulate natural gas production. Following the detonation, a reentry well was drilled and several gas production tests were conducted. The reentry well was shut-in after the last gas production test and was held in standby condition until the general cleanup was undertaken in 1972. A final cleanup was conducted after the emplacement and testing wells were plugged in 1976. However, some surface radiologic contamination resulted from decontamination of the drilling equipment and fallout from the gas flaring during drilling operations. With the exception of the drilling effluent pond, all surface contamination at the Rulison Site was removed during the cleanup operations. All mudpits and other excavations were backfilled, and both upper and lower drilling pads were leveled and dressed. This report provides information regarding known or suspected areas of contamination, previous cleanup activities, analytical results, a review of the regulatory status, the site`s physical environment, and future recommendations for Project Ruhson. Based on this research, several potential areas of contamination have been identified. These include the drilling effluent pond and mudpits used during drilling operations. In addition, contamination could migrate in the gas horizon.

  17. INSPIIRED: Quantification and Visualization Tools for Analyzing Integration Site Distributions

    Directory of Open Access Journals (Sweden)

    Charles C. Berry

    2017-03-01

    Full Text Available Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50 (unique cell progenitors contributing the most expanded 50% of progeny cell clones, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1 (SCID-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED.

  18. Natural phenomena hazards site characterization criteria

    Energy Technology Data Exchange (ETDEWEB)

    1994-03-01

    The criteria and recommendations in this standard shall apply to site characterization for the purpose of mitigating Natural Phenomena Hazards (wind, floods, landslide, earthquake, volcano, etc.) in all DOE facilities covered by DOE Order 5480.28. Criteria for site characterization not related to NPH are not included unless necessary for clarification. General and detailed site characterization requirements are provided in areas of meteorology, hydrology, geology, seismology, and geotechnical studies.

  19. Double tracks test site characterization report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-01

    This report presents the results of site characterization activities performed at the Double Tracks Test Site, located on Range 71 North, of the Nellis Air Force Range (NAFR) in southern Nevada. Site characterization activities included reviewing historical data from the Double Tracks experiment, previous site investigation efforts, and recent site characterization data. The most recent site characterization activities were conducted in support of an interim corrective action to remediate the Double Tracks Test Site to an acceptable risk to human health and the environment. Site characterization was performed using a phased approach. First, previously collected data and historical records sere compiled and reviewed. Generalized scopes of work were then prepared to fill known data gaps. Field activities were conducted and the collected data were then reviewed to determine whether data gaps were filled and whether other areas needed to be investigated. Additional field efforts were then conducted, as required, to adequately characterize the site. Characterization of the Double Tracks Test Site was conducted in accordance with the US Department of Energy`s (DOE) Streamlined Approach for Environmental Restoration (SAFER).

  20. Preliminary site characterization - final report

    Energy Technology Data Exchange (ETDEWEB)

    Clark, D.; Smith, L.B.

    1993-12-01

    This report summarizes the ecological unit reconnaissance conducted at the F-Area Burning/Rubble Pit(s) RCRA/CERCLA Unit (F-Area BRP) on August 30 and 31, 1993 as part of the RFI/RI baseline risk assessment for the waste unit The baseline risk assessment will assess the potential endangerment to human health and the environment associated with the unit and will be used to evaluate remediation criteria, if needed. The information presented in this report will be used in subsequent stages of the ecological risk assessment to refine the conceptual site model, assist in the selection of contaminants of concern, identify potential ecological receptors, and evaluate trophic relationships and other exposure pathways. The unit reconnaissance survey was conducted in accordance with Specification No. E-18272, Rev. 1 dated August 5, 1993, and the Draft {open_quotes}Ecological Risk Assessment Program Plan for Evaluation of Waste Sites on the Savannah River Site{close_quotes}. The objectives of the site reconnaissance were to: Assess the general characteristics of on-unit biological communities including mammals, birds, reptiles, amphibians, and any aquatic communities present. Determine the location, extent, and characteristics of on-unit ecological resources, such as forested areas and wetlands, that could serve as important wildlife habitat or provide other ecological functions. Identify any overt effects of contamination on biological communities. The field investigations included mapping and describing all wetland and terrestrial habitats; recording wildlife observations of birds, mammals, and reptiles; and investigating ecological resources in nearby downgradient and downstream areas which could be affected by mobile contaminants or future remedial actions. In preparation for the field investigation, existing unit information including aerial photographs and reports were reviewed to help identify and describe ecological resources at the waste unit.

  1. Stochastic Indicators for Waste Site Characterization

    Science.gov (United States)

    Christakos, George; Hristopulos, Dionissios T.

    1996-08-01

    Site characterization is an important prerequisite of risk assessment and remediation strategies. Evaluation of the health effects of groundwater and soil contamination depends on the adequate analysis of spatial heterogeneity, exceedance levels, and uncertainties. In this work we formulate and calculate stochastic indicators that provide a rigorous characterization of exposure levels in sites with heterogeneous contaminant distributions and offer valuable information for a cost-effective cleanup analysis. These site indicators are general and can be used for different types and distributions of groundwater and soil contaminants. Important properties of the stochastic indicators are examined which can evaluate the potential for contamination at large scales, and improve understanding of threatened and damaged ecosystems. Analytically tractable formulas are derived that allow the practical estimation of site indicators on the basis of experimental data. Scale and modeling effects on contaminant level analysis are examined in terms of the stochastic indicators. Site cleanup costs depend directly on inferred characteristics of the stochastic indicators, which thus can play an important role in waste site management. Applications are discussed that offer insight regarding certain aspects of stochastic site characterization. Analytical methods of site characterization are compared to numerical simulations. It is shown that the latter can provide a practical alternative to the former, but they could lead to inaccurate results if they are not interpreted carefully.

  2. Tools for noise characterization in Virgo

    Energy Technology Data Exchange (ETDEWEB)

    Accadia, T; Belletoile, A [Laboratoire d' Annecy-le-Vieux de Physique des Particules (LAPP), IN2P3/CNRS, Universite de Savoie, F-74941 Annecy-le-Vieux (France); Ballardin, G [European Gravitational Observatory (EGO), I-56021 Cascina (PI) (Italy); Barsuglia, M; Bouhou, B [AstroParticule et Cosmologie (APC), CNRS: UMR7164-IN2P3-Observatoire de Paris-Universite Denis Diderot-Paris 7 - CEA : DSM/IRFU (France); Bonnand, R [Laboratoire des Materiaux Avances (LMA), IN2P3/CNRS, F-69622 Villeurbanne, Lyon (France); Acernese, F; Antonucci, F; Astone, P; Barone, F; Bauer, Th S; Beker, M G; Birindelli, S; Bitossi, M; Bizouard, M A; Blom, M; Bondu, F; Bonelli, L; Boschi, V; Bosi, L, E-mail: elena.cuoco@ego-gw.i

    2010-08-01

    Several software tools were used to perform on-line and of-line noise analysis as a support to commissioning activities, to monitor the rate of glitches, the occurrence of non stationary noise, the presence of environmental contamination, the behavior of narrow spectral features and the coherence with auxiliary channels. We report about the use of these tools to study the main sources of identified noise: broadband, spectral lines and glitches. Plans for the upgrade of the tools will be presented, for example for lines identification purpose to let the scientists in control room do noise characterization in an easier way.

  3. Ames expedited site characterization demonstration at the former manufactured gas plant site, Marshalltown, Iowa

    Energy Technology Data Exchange (ETDEWEB)

    Bevolo, A.J.; Kjartanson, B.H.; Wonder, J.D.

    1996-03-01

    The goal of the Ames Expedited Site Characterization (ESC) project is to evaluate and promote both innovative technologies (IT) and state-of-the-practice technologies (SOPT) for site characterization and monitoring. In April and May 1994, the ESC project conducted site characterization, technology comparison, and stakeholder demonstration activities at a former manufactured gas plant (FMGP) owned by Iowa Electric Services (IES) Utilities, Inc., in Marshalltown, Iowa. Three areas of technology were fielded at the Marshalltown FMGP site: geophysical, analytical and data integration. The geophysical technologies are designed to assess the subsurface geological conditions so that the location, fate and transport of the target contaminants may be assessed and forecasted. The analytical technologies/methods are designed to detect and quantify the target contaminants. The data integration technology area consists of hardware and software systems designed to integrate all the site information compiled and collected into a conceptual site model on a daily basis at the site; this conceptual model then becomes the decision-support tool. Simultaneous fielding of different methods within each of the three areas of technology provided data for direct comparison of the technologies fielded, both SOPT and IT. This document reports the results of the site characterization, technology comparison, and ESC demonstration activities associated with the Marshalltown FMGP site. 124 figs., 27 tabs.

  4. Surface science tools for nanomaterials characterization

    CERN Document Server

    2015-01-01

    Fourth volume of a 40volume series on nano science and nanotechnology, edited by the renowned scientist Challa S.S.R. Kumar. This handbook gives a comprehensive overview about Surface Science Tools for Nanomaterials Characterization. Modern applications and state-of-the-art techniques are covered and make this volume an essential reading for research scientists in academia and industry.

  5. Probabilistic approaches for geotechnical site characterization and slope stability analysis

    CERN Document Server

    Cao, Zijun; Li, Dianqing

    2017-01-01

    This is the first book to revisit geotechnical site characterization from a probabilistic point of view and provide rational tools to probabilistically characterize geotechnical properties and underground stratigraphy using limited information obtained from a specific site. This book not only provides new probabilistic approaches for geotechnical site characterization and slope stability analysis, but also tackles the difficulties in practical implementation of these approaches. In addition, this book also develops efficient Monte Carlo simulation approaches for slope stability analysis and implements these approaches in a commonly available spreadsheet environment. These approaches and the software package are readily available to geotechnical practitioners and alleviate them from reliability computational algorithms. The readers will find useful information for a non-specialist to determine project-specific statistics of geotechnical properties and to perform probabilistic analysis of slope stability.

  6. Site characterization and petroleum hydrocarbon plume mapping

    Energy Technology Data Exchange (ETDEWEB)

    Ravishankar, K. [Harding Lawson Associates, Houston, TX (United States)

    1996-12-31

    This paper presents a case study of site characterization and hydrocarbon contamination plume mapping/delineation in a gas processing plant in southern Mexico. The paper describes innovative and cost-effective use of passive (non-intrusive) and active (intrusive) techniques, including the use of compound-specific analytical methods for site characterization. The techniques used, on a demonstrative basis, include geophysical, geochemical, and borehole drilling. Geochemical techniques used to delineate the horizontal extent of hydrocarbon contamination at the site include soil gas surveys. The borehole drilling technique used to assess the vertical extent of contamination and confirm geophysical and geochemical data combines conventional hollow-stem auguring with direct push-probe using Geoprobe. Compound-specific analytical methods, such as hydrocarbon fingerprinting and a modified method for gasoline range organics, demonstrate the inherent merit and need for such analyses to properly characterize a site, while revealing the limitations of noncompound-specific total petroleum hydrocarbon analysis. The results indicate that the techniques used in tandem can properly delineate the nature and extent of contamination at a site; often supplement or complement data, while reducing the risk of errors and omissions during the assessment phase; and provide data constructively to focus site-specific remediation efforts. 7 figs.

  7. Wind Energy Deployment Process and Siting Tools (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Tegen, S.

    2015-02-01

    Regardless of cost and performance, some wind projects cannot proceed to completion as a result of competing multiple uses or siting considerations. Wind energy siting issues must be better understood and quantified. DOE tasked NREL researchers with depicting the wind energy deployment process and researching development considerations. This presentation provides an overview of these findings and wind siting tools.

  8. Development of a site analysis tool for distributed wind projects

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, Shawn [The Cadmus Group, Inc., Waltham MA (United States)

    2012-02-28

    The Cadmus Group, Inc., in collaboration with the National Renewable Energy Laboratory (NREL) and Encraft, was awarded a grant from the Department of Energy (DOE) to develop a site analysis tool for distributed wind technologies. As the principal investigator for this project, Mr. Shawn Shaw was responsible for overall project management, direction, and technical approach. The product resulting from this project is the Distributed Wind Site Analysis Tool (DSAT), a software tool for analyzing proposed sites for distributed wind technology (DWT) systems. This user-friendly tool supports the long-term growth and stability of the DWT market by providing reliable, realistic estimates of site and system energy output and feasibility. DSAT-which is accessible online and requires no purchase or download of software-is available in two account types; Standard: This free account allows the user to analyze a limited number of sites and to produce a system performance report for each; and Professional: For a small annual fee users can analyze an unlimited number of sites, produce system performance reports, and generate other customizable reports containing key information such as visual influence and wind resources. The tool’s interactive maps allow users to create site models that incorporate the obstructions and terrain types present. Users can generate site reports immediately after entering the requisite site information. Ideally, this tool also educates users regarding good site selection and effective evaluation practices.

  9. Yucca Mountain Site Characterization Project Plan

    Energy Technology Data Exchange (ETDEWEB)

    Gertz, C.P.; Bartlett, J.

    1992-01-01

    The purpose of this document is to describe the Yucca Mountain Site Characterization Project (YMP) and establish an approved YMP baseline against which overall YMP progress and management effectiveness shall be measured. For the sake of brevity, this document will be referred to as the Project Plan throughout this document. This Project Plan only addresses activities up to the submittal of the repository license application (LA) to the Nuclear Regulatory Commission (NRC). A new Project Plan will be submitted to establish the technical, cost, and schedule baselines for the final design and construction phase of development extending through the start of repository operations, assuming that the site is determined to be suitable.

  10. 10 Web Tools to Create User-Friendly Sites

    Science.gov (United States)

    Pretlow, Cassi

    2008-01-01

    Surprisingly, many tools exist on the web that can help sites become more inviting and easier to use. By now, many are probably familiar with the free tools offered by Flickr, del.icio.us, or YouTube for embedding images, tags, and videos on webpages. This article presents a comprehensive list of some perhaps lesser-known but equally useful tools…

  11. Tools for characterizing biomembranes : final LDRD report.

    Energy Technology Data Exchange (ETDEWEB)

    Alam, Todd Michael; Stevens, Mark; Holland, Gregory P.; McIntyre, Sarah K.

    2007-10-01

    A suite of experimental nuclear magnetic resonance (NMR) spectroscopy tools were developed to investigate lipid structure and dynamics in model membrane systems. By utilizing both multinuclear and multidimensional NMR experiments a range of different intra- and inter-molecular contacts were probed within the membranes. Examples on pure single component lipid membranes and on the canonical raft forming mixture of DOPC/SM/Chol are presented. A unique gel phase pretransition in SM was also identified and characterized using these NMR techniques. In addition molecular dynamics into the hydrogen bonding network unique to sphingomyelin containing membranes were evaluated as a function of temperature, and are discussed.

  12. Digital Discernment: An E-Commerce Web Site Evaluation Tool

    Science.gov (United States)

    Sigman, Betsy Page; Boston, Brian J.

    2013-01-01

    Students entering the business workforce today may well share some responsibility for developing, revising, or evaluating their company's Web site. They may lack the experience, however, to critique their employer's Web presence effectively. The purpose of developing Digital Discernment, an e-commerce Web site evaluation tool, was to prepare…

  13. Site Characterization Progress Report No.20

    Energy Technology Data Exchange (ETDEWEB)

    DOE

    1999-10-01

    This is the 20th progress report issued by the U.S. Department of Energy. This report provides a summary-level discussion of Yucca Mountain Site Characterization Project progress. Accomplishments this period are presented in a format that identifies important progress achieved and conveys how that progress supports the near-term objectives in the U.S. Department of Energy's schedule. Greater detail is documented in the cited references and in deliverables listed in Appendix A to this report. Readers may request specific U.S. Department of Energy-approved program documents that are listed in Section 7, References, and Appendix A by contacting the Office of Civilian Radioactive Waste Management Information Line at 1-800-225-6972. This document provides a discussion of recently completed and ongoing activities conducted by the Yucca Mountain Site Characterization Project during the six-month reporting period from October 1, 1998, through March 31, 1999. Some information presented herein is by necessity preliminary, because some deliverables and reports that support the discussions have not been finalized. Projected future deliverables and reports are listed in Appendix B and are noted in the text as works in progress. Appendix C lists the status of milestone reports referenced in previous progress reports. A glossary of Yucca Mountain Site Characterization Project-specific terms used in this report is given in Appendix D.

  14. SWiFT site atmospheric characterization

    Energy Technology Data Exchange (ETDEWEB)

    Kelley, Christopher Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ennis, Brandon Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-01-01

    Historical meteorological tall tower data are analyzed from the Texas Tech University 200 m tower to characterize the atmospheric trends of the Scaled Wind Farm Technologies (SWiFT) site. In this report the data are analyzed to reveal bulk atmospheric trends, temporal trends and correlations of atmospheric variables. Through this analysis for the SWiFT turbines the site International Electrotechnical Commission (IEC) classification is determined to be class III-C. Averages and distributions of atmospheric variables are shown, revealing large fluctuations and the importance of understanding the actual site trends as opposed to simply using averages. The site is significantly directional with the average wind speed from the south, and particularly so in summer and fall. Site temporal trends are analyzed from both seasonal (time of the year) to daily (hour of the day) perspectives. Atmospheric stability is seen to vary most with time of day and less with time of year. Turbulence intensity is highly correlated with stability, and typical daytime unstable conditions see double the level of turbulence intensity versus that experienced during the average stable night. Shear, veer and atmospheric stability correlations are shown, where shear and veer are both highest for stable atmospheric conditions. An analysis of the Texas Tech University tower anemometer measurements is performed which reveals the extent of the tower shadow effects and sonic tilt misalignment.

  15. Analog site for fractured rock characterization. Annual report FY 1995

    Energy Technology Data Exchange (ETDEWEB)

    Long, J.C.S.; Loughty, C.; Faybishenko, B. [and others

    1995-10-01

    This report describes the accomplishments of the Analog Site for Fracture Rock Characterization Project during fiscal year 1995. This project is designed to address the problem of characterizing contaminated fractured rock. In order to locate contaminant plumes, develop monitoring schemes, and predict future fate and transport, the project will address the following questions: What parts of the system control flow-geometry of a fracture network? What physical processes control flow and transport? What are the limits on measurements to determine the above? What instrumentation should be used? How should it be designed and implemented? How can field tests be designed to provide information for predicting behavior? What numerical models are good predictors of the behavior of the system? The answers to these question can be used to help plan drilling programs that are likely to intersect plumes and provide effective monitoring of plume movement. The work is done at an {open_quotes}analogue{close_quotes} site, i.e., a site that is not contaminated, but has similar geology to sites that are contaminated, in order to develop tools and techniques without the financial, time and legal burdens of a contaminated site. The idea is to develop conceptual models and investigations tools and methodology that will apply to the contaminated sites in the same geologic regimes. The Box Canyon site, chosen for most of this work represents a unique opportunity because the Canyon walls allow us to see a vertical plane through the rock. The work represents a collaboration between the Lawrence Berkeley National Laboratory (LBL), Stanford University (Stanford), Idaho National Engineering Laboratory (INEL) and Parsons Environmental Engineering (Parsons). LBL and Stanford bring extensive experience in research in fractured rock systems. INEL and Parsons bring significant experience with the contamination problem at INEL.

  16. Social network sites: Indispensable or optional social tools?

    DEFF Research Database (Denmark)

    Shklovski, Irina

    2012-01-01

    Much research has enumerated potential benefits of online social network sites. Given the pervasiveness of these sites and the numbers of people that use them daily, both re-search and media tend to make the assumption that social network sites have become indispensible to their users. Based...... on the analysis of qualitative data from users of social network sites in Russia and Kazakhstan, this paper consid-ers under what conditions social network sites can become indispensable to their users and when these technologies remain on the periphery of life despite fulfilling useful func-tions. For some...... respondents, these sites had become indis-pensable tools as they were integrated into everyday rou-tines of communicating with emotionally important and proximal contacts and were often used for coordination of offline activities. For others social network sites remained spaces where they occasionally visited...

  17. Preliminary siting characterization Salt Disposition Facility - Site B

    Energy Technology Data Exchange (ETDEWEB)

    Wyatt, D.

    2000-01-04

    A siting and reconnaissance geotechnical program has been completed in S-Area at the Savannah River Site in South Carolina. This program investigated the subsurface conditions for the area known as ``Salt Disposition Facility (SDF), Site B'' located northeast of H-Area and within the S-Area. Data acquired from the Site B investigation includes both field exploration and laboratory test data.

  18. GEOMETRICAL CHARACTERIZATION OF MICRO END MILLING TOOLS

    DEFF Research Database (Denmark)

    Borsetto, Francesca; Bariani, Paolo

    /lubricants, milling strategies and controls. Moreover the accuracy of tool geometry directly affects the performance of the milling process influencing the dimensional tolerances of the machined part, the surface topography, the chip formation, the cutting forces and the tool-life. The dimensions of certain......The milling process is one of the most common metal removal operation used in industry. This machining process is well known since the beginning of last century and has experienced, along the years, many improvements of the basic technology, as concerns tools, machine tools, coolants...... geometrical details, as for instance the cutting edge radius, are determined by characteristics of the manufacturing process, tool material, coating etc. While for conventional size end mills the basic tool manufacturing process is well established, the reduction of the size of the tools required...

  19. NRC staff site characterization analysis of the Department of Energy`s Site Characterization Plan, Yucca Mountain Site, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-08-01

    This Site Characterization Analysis (SCA) documents the NRC staff`s concerns resulting from its review of the US Department of Energy`s (DOE`s) Site Characterization Plan (SCP) for the Yucca Mountain site in southern Nevada, which is the candidate site selected for characterization as the nation`s first geologic repository for high-level radioactive waste. DOE`s SCP explains how DOE plans to obtain the information necessary to determine the suitability of the Yucca Mountain site for a repository. NRC`s specific objections related to the SCP, and major comments and recommendations on the various parts of DOE`s program, are presented in SCA Section 2, Director`s Comments and Recommendations. Section 3 contains summaries of the NRC staff`s concerns for each specific program, and Section 4 contains NRC staff point papers which set forth in greater detail particular staff concerns regarding DOE`s program. Appendix A presents NRC staff evaluations of those NRC staff Consultation Draft SCP concerns that NRC considers resolved on the basis of the SCP. This SCA fulfills NRC`s responsibilities with respect to DOE`s SCP as specified by the Nuclear Waste Policy Act (NWPA) and 10 CFR 60.18. 192 refs., 2 tabs.

  20. Evaluation of Phosphorus Site Assessment Tools: Lessons from the USA.

    Science.gov (United States)

    Sharpley, Andrew; Kleinman, Peter; Baffaut, Claire; Beegle, Doug; Bolster, Carl; Collick, Amy; Easton, Zachary; Lory, John; Nelson, Nathan; Osmond, Deanna; Radcliffe, David; Veith, Tamie; Weld, Jennifer

    2017-11-01

    Critical source area identification through phosphorus (P) site assessment is a fundamental part of modern nutrient management planning in the United States, yet there has been only sparse testing of the many versions of the P Index that now exist. Each P site assessment tool was developed to be applicable across a range of field conditions found in a given geographic area, making evaluation extremely difficult. In general, evaluation with in-field monitoring data has been limited, focusing primarily on corroborating manure and fertilizer "source" factors. Thus, a multiregional effort (Chesapeake Bay, Heartland, and Southern States) was undertaken to evaluate P Indices using a combination of limited field data, as well as output from simulation models (i.e., Agricultural Policy Environmental eXtender, Annual P Loss Estimator, Soil and Water Assessment Tool [SWAT], and Texas Best Management Practice Evaluation Tool [TBET]) to compare against P Index ratings. These comparisons show promise for advancing the weighting and formulation of qualitative P Index components but require careful vetting of the simulation models. Differences among regional conclusions highlight model strengths and weaknesses. For example, the Southern States region found that, although models could simulate the effects of nutrient management on P runoff, they often more accurately predicted hydrology than total P loads. Furthermore, SWAT and TBET overpredicted particulate P and underpredicted dissolved P, resulting in correct total P predictions but for the wrong reasons. Experience in the United States supports expanded regional approaches to P site assessment, assuming closely coordinated efforts that engage science, policy, and implementation communities, but limited scientific validity exists for uniform national P site assessment tools at the present time. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

  1. Site characterization plan thermal goals reevaluation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-09-08

    The Site Characterization Plan (SCP) (DOE, 1988) attempted to define surrogate criteria that could be used to establish potential repository performance. These criteria or SCP thermal goals were developed from knowledge existing at the time and, as a reference case, emphasized performance for waste emplacement in a vertical borehole. Since that time, new knowledge has become available and some additional analyses of thermal loading have been performed. Additionally, other emplacement modes such as in-drift emplacement are being considered to accommodate larger waste packages. New concepts such as ``extended hot`` are also being considered as possible methods to achieve improved waste isolation. Thus it became clear that the thermal goals established in the SCP should be reevaluated. A Working Group was formed to reassess the SCP thermal goals to determine whether each goal was still valid, if there were goals that needed to be added, and what if any effort was needed to reduce the uncertainty associated with a particular goal. The objectives of the effort were to: (1) provide thermal goals that would support the FY 1993 Thermal Loading Systems Study; (2) help focus the planned testing and analysis efforts; and (3) acquire data that potentially could be used to initiate a change to the project technical baseline. Sixteen thermal goals were evaluated; fifteen were from various sections of the SCP; one goal was added, and another was split into two to include in-drift emplacement. The group`s findings and recommendations are presented.

  2. Characterization of the Source Physics Experiment Site

    Science.gov (United States)

    Sussman, A. J.; Schultz-Fellenz, E. S.; Broome, S. T.; Townsend, M.; Abbott, R. E.; Snelson, C. M.; Cogbill, A. H.; Conklin, G.; Mitra, G.; Sabbeth, L.

    2012-12-01

    Designed to improve long-range treaty monitoring capabilities, the Source Physics Experiments, conducted at the Nevada National Security Site, also provide an opportunity to advance near-field monitoring and field-based investigations of suspected underground test locations. In particular, features associated with underground testing can be evaluated using Source Physics Experiment activities as analogs, linking on-site inspections with remote sensing technologies. Following a calibration shot (SPE 1), SPE 2 (10/2011) and SPE 3 (07/2012) were performed in the same emplacement hole with 1.0 ton of explosives at 150 ft depth. Because one of the goals of the Source Physics Experiments is to determine damage effects on seismic wave propagation and improve modeling capabilities, a key component in the predictive component and ultimate validation of the models is a full understanding of the intervening geology between the source and instrumented bore holes. Ground-based LIDAR and fracture mapping, mechanical properties determined via laboratory testing of rock core, discontinuity analysis and optical microscopy of the core rocks were performed prior to and following each experiment. In addition, gravity and magnetic data were collected between SPE 2 and 3. The source region of the explosions was also characterized using cross-borehole seismic tomography and vertical seismic profiling utilizing two sets of two boreholes within 40 meters of ground zero. The two sets of boreholes are co-linear with the explosives hole in two directions. Results of the LIDAR collects from both SPE 2 and 3 indicate a permanent ground displacement of up to several centimeters aligning along the projected surface traces of two faults observed in the core and fractures mapped at the surface. Laboratory testing and optical work show a difference in the characteristics of the rocks below and above 40 feet and within the fault zones.The estimated near-surface densities from the gravity survey show

  3. Final Hanford Site Transuranic (TRU) Waste Characterization QA Project Plan

    Energy Technology Data Exchange (ETDEWEB)

    GREAGER, T.M.

    1999-09-09

    The Transuranic Waste Characterization Quality Assurance Program Plan required each US Department of Energy (DOE) site that characterizes transuranic waste to be sent the Waste Isolation Pilot Plan that addresses applicable requirements specified in the QAPP.

  4. Hydrogeological-Geophysical Methods for Subsurface Site Characterization - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Rubin, Yoram

    2001-01-01

    The goal of this research project is to increase water savings and show better ecological control of natural vegetation by developing hydrogeological-geophysical methods for characterizing the permeability and content of water in soil. The ground penetrating radar (GPR) tool was developed and used as the surface geophysical method for monitoring water content. Initial results using the tool suggest that surface GPR is a viable technique for obtaining precision volumetric water content profile estimates, and that laboratory-derived petrophysical relationships could be applied to field-scale GPR data. A field-scale bacterial transport study was conducted within an uncontaminated sandy Pleistocene aquifer to evaluate the importance of heterogeneity in controlling the transport of bacteria. Geochemical, hydrological, geological, and geophysical data were collected to characterize the site prior to and after chemical and bacterial injection experiments. Study results shows that, even within the fairly uniform shallow marine deposits of the narrow channel focus area, heterogeneity existed that influenced the chemical tracer transport over lateral distances of a few meters and vertical distances of less than a half meter. The interpretation of data suggest that the incorporation of geophysical data with limited hydrological data may provide valuable information about the stratigraphy, log conductivity values, and the spatial correlation structure of log conductivity, which have traditionally been obtainable only by performing extensive and intrusive hydrological sampling.

  5. Nanosystem Characterization Tools in the Life Sciences

    Science.gov (United States)

    Kumar, Challa S. S. R.

    2006-01-01

    This first dedicated, all-encompassing text characterizes nanomaterials intended for biological or physiological environments and biomedical applications, in particular for medicine, healthcare, pharmaceuticals and human wellness. It finally fills the gap for a concise overview of a wide range of different characterization techniques and how to best employ them in the context of nanoscale life science research. It thus serves as a single source of information gathering up the knowledge otherwise spread over many journal articles, and provides an overall picture to members of all the disciplines involved. This handy volume covers all important probing techniques, including nuclear and electron spin resonance, light scattering, infrared and Raman spectroscopy, atomic force microscopy, magnetic resonance, tomography, x-ray techniques, and microbalance measurement of antibody binding. Biochemists, biologists, chemists, materials scientists, and materials engineers as well as all others working in the pharmaceutical and chemical industries or at related research institutions will here a book of great value and importance.

  6. Measurement Sets and Sites Commonly Used for Characterization

    Science.gov (United States)

    Pagnutti, Mary; Holekamp, Kara; Ryan, Robert; Sellers, Richard; Davis, Bruce; Zanoni, Vicki

    2002-01-01

    Scientists at NASA's Earth Science Applications Directorate are creating a well-characterized Verification & Validation (V&V) site at the Stennis Space Center. This site enables the in-flight characterization of remote sensing systems and the data they acquire. The data are predominantly acquired by commercial, high spatial resolution satellite systems, such as IKONOS and QuickBird 2, and airborne systems. The smaller scale of these newer high resolution remote sensing systems allows scientists to characterize the geometric, spatial, and radiometric data properties using a single V&V site. The targets and techniques used to characterize data from these newer systems can differ significantly from the techniques used to characterize data from the earlier, coarser spatial resolution systems. Scientists are also using the SSC V&V site to characterize thermal infrared systems and active LIDAR systems. SSC employs geodetic targets, edge targets, radiometric tarps, and thermal calibration ponds to characterize remote sensing data products. This paper presents a proposed set of required measurements for visible through long-wave infrared remote sensing systems and a description of the Stennis characterization. Other topics discussed include: 1) The use of ancillary atmospheric and solar measurements taken at SSC that support various characterizations; 2) Additional sites used for radiometric, geometric, and spatial characterization in the continental United States; 3) The need for a standardized technique to be adopted by CEOS and other organizations.

  7. Communication tools between Grid virtual organisations, middleware deployers and sites

    CERN Document Server

    Dimou, Maria

    2008-01-01

    Grid Deployment suffers today from the difficulty to reach users and site administrators when a package or a configuration parameter changes. Release notes, twiki pages and news’ broadcasts are not efficient enough. The interest of using GGUS as an efficient and effective intra-project communication tool is the message to the user community presented here. The purpose of GGUS is to bring together End Users and Supporters in the Regions where the Grid is deployed and in operation. Today’s Grid usage is still very far from the simplicity and functionality of the web. While pressing for middleware usability, we try to turn the Global Grid User Support (GGUS) into the central tool for identifying areas in the support environment that need attention. To do this, we exploit GGUS' capacity to expand, by including new Support Units that follow the project's operational structure. Using tailored GGUS database searches we obtain concrete results that prove where we need to improve procedures, Service Level Agreemen...

  8. International Symposium on Site Characterization for CO2Geological Storage

    Energy Technology Data Exchange (ETDEWEB)

    Tsang, Chin-Fu

    2006-02-23

    Several technological options have been proposed to stabilize atmospheric concentrations of CO{sub 2}. One proposed remedy is to separate and capture CO{sub 2} from fossil-fuel power plants and other stationary industrial sources and to inject the CO{sub 2} into deep subsurface formations for long-term storage and sequestration. Characterization of geologic formations for sequestration of large quantities of CO{sub 2} needs to be carefully considered to ensure that sites are suitable for long-term storage and that there will be no adverse impacts to human health or the environment. The Intergovernmental Panel on Climate Change (IPCC) Special Report on Carbon Dioxide Capture and Storage (Final Draft, October 2005) states that ''Site characterization, selection and performance prediction are crucial for successful geological storage. Before selecting a site, the geological setting must be characterized to determine if the overlying cap rock will provide an effective seal, if there is a sufficiently voluminous and permeable storage formation, and whether any abandoned or active wells will compromise the integrity of the seal. Moreover, the availability of good site characterization data is critical for the reliability of models''. This International Symposium on Site Characterization for CO{sub 2} Geological Storage (CO2SC) addresses the particular issue of site characterization and site selection related to the geologic storage of carbon dioxide. Presentations and discussions cover the various aspects associated with characterization and selection of potential CO{sub 2} storage sites, with emphasis on advances in process understanding, development of measurement methods, identification of key site features and parameters, site characterization strategies, and case studies.

  9. The Exoplanet Characterization ToolKit (ExoCTK)

    Science.gov (United States)

    Stevenson, Kevin; Fowler, Julia; Lewis, Nikole K.; Fraine, Jonathan; Pueyo, Laurent; Valenti, Jeff; Bruno, Giovanni; Filippazzo, Joseph; Hill, Matthew; Batalha, Natasha E.; Bushra, Rafia

    2018-01-01

    The success of exoplanet characterization depends critically on a patchwork of analysis tools and spectroscopic libraries that currently require extensive development and lack a centralized support system. Due to the complexity of spectroscopic analyses and initial time commitment required to become productive, there are currently a limited number of teams that are actively advancing the field. New teams with significant expertise, but without the proper tools, face prohibitively steep hills to climb before they can contribute. As a solution, we are developing an open-source, modular data analysis package in Python and a publicly facing web interface focused primarily on atmospheric characterization of exoplanets and exoplanet transit observation planning with JWST. The foundation of these software tools and libraries exist within pockets of the exoplanet community. Our project will gather these seedling tools and grow a robust, uniform, and well maintained exoplanet characterization toolkit.

  10. Measurement Sets and Sites Commonly used for Characterizations

    Science.gov (United States)

    Pagnutti, Mary; Holekamp, Kara; Ryan, Robert; Blonski, Slawomir; Sellers, Richard; Davis, Bruce; Zanoni, Vicki

    2002-01-01

    Scientists with NASA's Earth Science Applications Directorate are creating a well-characterized Verification & Validation (V&V) site at the Stennis Space Center (SSC). This site enables the in-flight characterization of remote sensing systems and the data that they require. The data are predominantly acquired by commercial, high-spatial resolution satellite systems, such as IKONOS and QuickBird 2, and airborne systems. The smaller scale of these newer high-resolution remote sensing systems allows scientists to characterize the geometric, spatial, and radiometric data properties using a single V&V site. The targets and techniques used to characterize data from these newer systems can differ significantly from the earlier, coarser spatial resolution systems. Scientists are also using the SSC V&V site to characterize thermal infrared systems and active Light Detection and Ranging (LIDAR) systems. SSC employs geodetic targets, edge targets, radiometric tarps, and thermal calibration ponds to characterize remote sensing data products. This paper presents a proposed set of required measurements for visible-through-longwave infrared remote sensing systems, and a description of the Stennis characterization. Other topics discussed inslude: 1) use of ancillary atmospheric and solar measurements taken at SSC that support various characterizations, 2) other sites used for radiometric, geometric, and spatial characterization in the continental United States,a nd 3) the need for a standardized technique to be adopted by the Committee on Earth Observation Satellites (CEOS) and other organizations.

  11. Characterization of the Hanford Site and environs

    Energy Technology Data Exchange (ETDEWEB)

    Cushing, C.E. (ed.)

    1991-03-01

    The US Department of Energy (DOE) proposes to site, construct, and operate a new production reactor (NPR) intended to produce materials for the US nuclear weapons program. The DOE has determined that this proposed action constitutes an action that may significantly affect the quality of the human environment; therefore, the DOE is preparing an environmental impact statement (EIS) to assess the potential impacts of the proposed action and reasonable alternatives on the human and natural environment. The NPR-EIS is being prepared in accordance with Section 102(2)(C) of the National Environmental Policy Act of 1969 (NEPA), as implemented in regulations (40 CFR 1500--1508) promulgated by the Council on Environmental Quality (CEQ). Information on the potentially affected environment at the Hanford Site and its environs was provided to ANL by PNL in various submissions during CY-1989, and some of that information was consolidated into this report, which is considered to be supporting documentation for the NPR-EIS. 93 refs., 35 figs., 46 tabs.

  12. Report of early site suitability evaluation of the potential repository site at Yucca Mountain, Nevada; Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Younker, J.L.; Andrews, W.B.; Fasano, G.A.; Herrington, C.C.; Mattson, S.R.; Murray, R.C. [Science Applications International Corp., Las Vegas, NV (United States); Ballou, L.B.; Revelli, M.A. [Lawrence Livermore National Lab., CA (United States); Ducharme, A.R.; Shephard, L.E. [Sandia National Labs., Albuquerque, NM (United States); Dudley, W.W.; Hoxie, D.T. [Geological Survey, Denver, CO (United States); Herbst, R.J.; Patera, E.A. [Los Alamos National Lab., NM (United States); Judd, B.R. [Decision Analysis Co., Portola Valley, CA (United States); Docka, J.A.; Rickertsen, L.D. [Weston Technical Associates, Washington, DC (United States)

    1992-01-01

    This study evaluated the technical suitability of Yucca Mountain, Nevada, as a potential site for a mined geologic repository for the permanent disposal of radioactive waste. The evaluation was conducted primarily to determine early in the site characterization program if there are any features or conditions at the site that indicate it is unsuitable for repository development. A secondary purpose was to determine the status of knowledge in the major technical areas that affect the suitability of the site. This early site suitability evaluation (ESSE) was conducted by a team of technical personnel at the request of the Associate Director of the US Department of Energy (DOE) Office of Geologic Disposal, a unit within the DOE`s Office of Civilian Radioactive Waste Management. The Yucca Mountain site has been the subject of such evaluations for over a decade. In 1983, the site was evaluated as part of a screening process to identify potentially acceptable sites. The site was evaluated in greater detail and found suitable for site characterization as part of the Environmental Assessment (EA) (DOE, 1986) required by the Nuclear Waste Policy Act of 1982 (NWPA). Additional site data were compiled during the preparation of the Site Characterization Plan (SCP) (DOE, 1988a). This early site suitability evaluation has considered information that was used in preparing both-documents, along with recent information obtained since the EA and SCP were published. This body of information is referred to in this report as ``current information`` or ``available evidence.``

  13. Developing Hydrogeological Site Characterization Strategies based on Human Health Risk

    Science.gov (United States)

    de Barros, F.; Rubin, Y.; Maxwell, R. M.

    2013-12-01

    In order to provide better sustainable groundwater quality management and minimize the impact of contamination in humans, improved understanding and quantification of the interaction between hydrogeological models, geological site information and human health are needed. Considering the joint influence of these components in the overall human health risk assessment and the corresponding sources of uncertainty aid decision makers to better allocate resources in data acquisition campaigns. This is important to (1) achieve remediation goals in a cost-effective manner, (2) protect human health and (3) keep water supplies clean in order to keep with quality standards. Such task is challenging since a full characterization of the subsurface is unfeasible due to financial and technological constraints. In addition, human exposure and physiological response to contamination are subject to uncertainty and variability. Normally, sampling strategies are developed with the goal of reducing uncertainty, but less often they are developed in the context of their impacts on the overall system uncertainty. Therefore, quantifying the impact from each of these components (hydrogeological, behavioral and physiological) in final human health risk prediction can provide guidance for decision makers to best allocate resources towards minimal prediction uncertainty. In this presentation, a multi-component human health risk-based framework is presented which allows decision makers to set priorities through an information entropy-based visualization tool. Results highlight the role of characteristic length-scales characterizing flow and transport in determining data needs within an integrated hydrogeological-health framework. Conditions where uncertainty reduction in human health risk predictions may benefit from better understanding of the health component, as opposed to a more detailed hydrogeological characterization, are also discussed. Finally, results illustrate how different dose

  14. Advances in characterizing ubiquitylation sites by mass spectrometry

    DEFF Research Database (Denmark)

    Sylvestersen, K.B.; Young, C.; Nielsen, M.L.

    2013-01-01

    The attachment of one or more ubiquitin moieties to proteins plays a central regulatory mechanism in eukaryotic cells. Protein ubiquitylation regulates numerous cellular processes, including protein degradation, signal transduction, DNA repair and cell division. The characterization...... of ubiquitylation is a two-fold challenge that involves the mapping of ubiquitylation sites and the determination of ubiquitin chain topology. This review focuses on the technical advances in the mass spectrometry-based characterization of ubiquitylation sites, which have recently involved the large...

  15. Leachate characterization of active and closed dump sites in Port ...

    African Journals Online (AJOL)

    ... such as air, soil, surface and ground water. The knowledge of the composition of leachates is important to determine the dump sites that require immediate remediation attention and their effective treatment approach. This study characterizes the leachate quality of both active and closed dump sites in Port Harcourt City.

  16. Law enforcement tools available at the Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Hofstetter, K.J.

    2000-03-29

    A number of nuclear technologies developed and applied at the Savannah River Site in support of nuclear weapons material production and environmental remediation can be applied to problems in law enforcement. Techniques and equipment for high-sensitivity analyses of samples are available to identify and quantify trace elements and establish origins and histories of forensic evidence removed from crime scenes. While some of theses capabilities are available at local crime laboratories, state-of-the-art equipment and breakthroughs in analytical techniques are continually being developed at DOE laboratories. Extensive experience with the handling of radioactive samples at the DOE labs minimizes the chances of cross-contamination of evidence received from law enforcement. In addition to high-sensitivity analyses, many of the field techniques developed for use in a nuclear facility can assist law enforcement personnel in detecting illicit materials and operations, in retrieving of pertinent evidence and in surveying crime scenes. Some of these tools include chemical sniffers, hand-held detectors, thermal imaging, etc. In addition, mobile laboratories can be deployed to a crime scene to provide field screening of potential evidence. A variety of portable sensors can be deployed on vehicle, aerial, surface or submersible platforms to assist in the location of pertinent evidence or illicit operations. Several specific nuclear technologies available to law enforcement and their potential uses are discussed.

  17. Protecting subcontractor personnel during hazardous waste site characterization

    Energy Technology Data Exchange (ETDEWEB)

    Lankford, B.R.

    1987-01-01

    This paper covers Industrial Hygiene involvement in the Site Characterization Program, focusing on the field oversight responsibilities. It discusses the different types and levels of protective equipment, gives an example of the type of situation that can arise from field characterization efforts, and gives a brief summary of health protection program elements. 3 figs., 3 tabs.

  18. Measurement techniques for radiological characterization of contaminated sites

    Energy Technology Data Exchange (ETDEWEB)

    Loos, M.

    1996-09-18

    Once the decision is taken to characterize a contaminated site, appropriate measurement techniques must be selected. The choice will depend on the available information, on the nature and extent of the contamination, as well as on available resources (staff and budget). Some techniques are described on the basis of examples of characterization projects (e.g. Olen area in Belgium).

  19. Final Hanford Site Transuranic (TRU) Waste Characterization QA Project Plan

    Energy Technology Data Exchange (ETDEWEB)

    GREAGER, T.M.

    1999-12-14

    The Transuranic Waste Characterization Quality Assurance Program Plan required each U.S. Department of Energy (DOE) site that characterizes transuranic waste to be sent the Waste Isolation Pilot Plan that addresses applicable requirements specified in the quality assurance project plan (QAPP).

  20. Gulf of Mexico miocene CO₂ site characterization mega transect

    Energy Technology Data Exchange (ETDEWEB)

    Meckel, Timothy [Univ. of Austin, Austin, TX (United Staes); Trevino, Ramon [Univ. of Austin, Austin, TX (United Staes)

    2014-12-01

    m) of data allowed for the identification and mapping of unconformable surfaces including what is probably a surface associated with the last Pleistocene glacial lowstand. The identification of a previously unrecognized (in commercial seismic data) gas chimney that was clearly defined in the 2013 HR3D survey, indicates that HR3D surveys may be useful as both a characterization tool for the overburden of a potential carbon sequestration site and as an additional monitoring tool for future engineered injection sites. Geochemical modeling indicated that injection of CO₂ would result in minor dissolution of calcite, K-feldspar and albite. In addition, modeling of typical brines in Miocene age rocks indicate that approximately 5% of injection capacity would result from CO₂ dissolution into the brine. After extensive searches, no rock samples of the Marginulina A and Amphistegina B seals (“caprocks”) were obtained, but analyses of available core samples of other Miocene age mudrocks (seals or caprocks) indicate that they have sealing ability sufficient for potential CO2 storage in underlying sandstone units.

  1. Site characterization for hybrid system construction

    Energy Technology Data Exchange (ETDEWEB)

    Saldana, R.; Miranda, U.; Medrano, M. C. [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1997-12-31

    The basic reason to use alternative systems for electricity generation, in most cases, is the lack of electricity services, such as isolated rural communities which are located far away from the electric distribution line, and the cost of its extension is too expensive, while decentralized power systems can be an economic and appropriate solution to providing these services. Up to now there are several technological options for rural electrification using PV modules, wind plants, water-power plants, anaerobic digesters, or a combination of some of them, according to the availability of energetic resources. The applications include centralized or decentralized systems, autonomous or hybrid systems, isolated or interconnected to the electric line, etc. A particular hybrid system design can be done considering two general aspects, first it is necessary to know the electric consumption that will be supplied, taking into account present and future necessities and how local energetic resources are present in a selected site. Finally, also it is necessary to carry out an economic analysis to determine the cost of kilowatt-hour generated using local energetic resources and compare it with the cost of electricity produced by conventional power systems. [Espanol] La razon principal para el uso de sistemas alternativos de generacion de electricidad, en la mayoria de los casos, es la falta de servicios de electricidad, tal como en las comunidades rurales aisladas localizadas lejos de linea de distribucion electrica, donde el costo de su extension es demasiado caro, mientras que los sistemas descentralizados de energia pueden ser una solucion economica y adecuada para proporcionar estos servicios. Hasta ahora existen varias opciones tecnologicas para la electrificacion rural usando modulos fotovoltaicos, aerogeneradores, plantas hidroelectricas, digestores anaerobicos o una combinacion de algunos de ellos, de acuerdo con la disponibilidad de los recursos energeticos. Las

  2. Characterization recommendations for waste sites at the Savannah River Plant

    Energy Technology Data Exchange (ETDEWEB)

    Carlton, W.H.; Gordon, D.E.; Johnson, W.F.; Kaback, D.S.; Looney, B.B.; Nichols, R.L.; Shedrow, C.B.

    1987-11-01

    One hundred and sixty six disposal facilities that received or may have received waste materials resulting from operations at the Savannah River Plant (SRP) have been identified. These waste range from innocuous solid and liquid materials (e.g., wood piles) to process effluents that contain hazardous and/or radioactive constituents. The waste sites have been grouped into 45 categories according the the type of waste materials they received. Waste sites are located with SRP coordinates, a local Department of Energy (DOE) grid system whose grid north is 36 degrees 22 minutes west of true north. DOE policy is to close all waste sites at SRP in a manner consistent with protecting human health and environment and complying with applicable environmental regulations (DOE 1984). A uniform, explicit characterization program for SRP waste sites will provide a sound technical basis for developing closure plans. Several elements are summarized in the following individual sections including (1) a review of the history, geohydrology, and available characterization data for each waste site and (2) recommendations for additional characterization necessary to prepare a reasonable closure plan. Many waste sites have been fully characterized, while others have not been investigated at all. The approach used in this report is to evaluate available groundwater quality and site history data. For example, groundwater data are compared to review criteria to help determine what additional information is required. The review criteria are based on regulatory and DOE guidelines for acceptable concentrations of constituents in groundwater and soil.

  3. Site characterization data from the Area 5 science boreholes, Nevada Test Site, Nye County, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Blout, D.O.; Hammermeister, P.; Zukosky, K.A.

    1995-02-01

    The Science Borehole Project consists of eight boreholes that were drilled (from 45.7 m [150 ft] to 83.8 m [275 ft] depth) in Area 5 of the Nevada Test Site, Nye County, Nevada, on behalf of the US Department of Energy. These boreholes are part of the Area 5 Site Characterization Program developed to meet data needs associated with regulatory requirements applicable to the disposal of low-level and mixed waste at this site. This series of boreholes was specifically designed to characterize parameters controlling near-surface gas transport and to monitor changes in these and liquid flow-related parameters over time. These boreholes are located along the four sides of the approximately 2.6-km{sup 2} (1-mi{sup 2}) Area 5 Radioactive Waste Management Site to provide reasonable spatial coverage for sampling and characterization. Laboratory testing results of samples taken from core and drill cuttings are reported.

  4. Site Characterization of Italian Strong Motion Recording Stations

    Science.gov (United States)

    Scasserra, Giuseppe; Stewart, Jonathan P.; Kayen, Robert E.; Lanzo, Giuseppe

    2008-07-01

    A dataset of site conditions at 101 Italian ground motion stations with recorded motions has been compiled that includes geologic characteristics and seismic velocities. Geologic characterization is derived principally from local geologic investigations by ENEL that include detailed mapping and cross sections. For sites lacking such detailed geologic characterization, the geology maps of the by Servizio Geologico d'Italia are used. Seismic velocities are extracted from the literature and the files of consulting engineers, geologists and public agencies for 33 sites. Data sources utilized include post earthquake site investigations (Friuli and Irpinia events), microzonation studies, and miscellaneous investigations performed by researchers or consulting engineers/geologists. Additional seismic velocities are measured by the authors using the controlled source spectral analysis of surface waves (SASW) method for 18 sites that recorded the 1997-1998 Umbria Marche earthquake sequence. The compiled velocity measurements provide data for 51 of the 101 sites. For the remaining sites, the average seismic velocity in the upper 30 m (Vs30) is estimated using a hybrid approach. For young Quaternary alluvium, Vs30 an existing empirical relationship for California sites by Wills and Clahan (2006) is used, which we justify by validating this relationship against Italian data. For Tertiary Limestone and Italian Mesozoic rocks, empirical estimates of Vs30 are developed using the available data. This work is also presented in Scasserra et al. (2008: JEE, in review).

  5. Site Characterization for a Deep Borehole Field Test

    Science.gov (United States)

    Kuhlman, K. L.; Hardin, E. L.; Freeze, G. A.; Sassani, D.; Brady, P. V.

    2015-12-01

    The US Department of Energy Office of Nuclear Energy is at the beginning of 5-year Deep Borehole Field Test (DBFT) to investigate the feasibility of constructing and characterizing two boreholes in crystalline basement rock to a depth of 5 km (16,400 ft). The concept of deep borehole disposal for radioactive waste has some advantages over mined repositories, including incremental construction and loading, the enhanced natural barriers provided by deep continental crystalline basement, and reduced site characterization. Site characterization efforts need to determine an eligible site that does not have the following disqualifying characteristics: greater than 2 km to crystalline basement, upward vertical fluid potential gradients, presence of economically exploitable natural resources, presence of high permeability connection to the shallow subsurface, and significant probability of future seismic or volcanic activity. Site characterization activities for the DBFT will include geomechanical (i.e., rock in situ stress state, and fluid pressure), geological (i.e., rock and fracture infill lithology), hydrological (i.e., quantity of fluid, fluid convection properties, and solute transport mechanisms), and geochemical (i.e., rock-water interaction and natural tracers) aspects. Both direct (i.e., sampling and in situ testing) and indirect (i.e., borehole geophysical) methods are planned for efficient and effective characterization of these site aspects and physical processes. Borehole-based characterization will be used to determine the variability of system state (i.e., stress, pressure, temperature, and chemistry) with depth, and interpretation of material and system parameters relevant to numerical site simulation. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE

  6. Tomographic Site Characterization Using CPT, ERT, and GPR

    Energy Technology Data Exchange (ETDEWEB)

    Rexford M. Morey

    1997-05-23

    The U.S. Department of Energy (DOE) is responsible for the cleanup of inactive DOE sites and for bringing DOE sites and facilities into compliance with federal, state and local laws and regulations. The DOE's Office of Environmental Management (EM) needs advanced technologies that can make environmental restoration and waste management operations more efficient and less costly. These techniques are required to better characterize the physical, hydrogeological, and chemical properties of the subsurface while minimizing and optimizing the use of boreholes and monitoring wells. Today the cone penetrometer technique (CPT) is demonstrating the value of a minimally invasive deployment system fix site characterization. Applied Research Associates is developing two new sensor packages for site characterization and monitoring. The two new methods are: . Electrical Resistivity Tomography (ERT) and . Ground Penetrating Radar (GPR) Tomography. These sensor systems are now integrated with the Cone Penetrometer Technique (CPT). The results of this program now make it possible to install ERT and GPR units by CPT methods and thereby reduce installation costs and total costs for ERT and GPR surveys. These two techniques can complement each other in regions of low resistivity where ERT is more effective and regions of high resistivity where GPR is more effective. The results show that CPT-installed GeoWells can be used in both ERT and GPR borehole tomographic subsurface imaging. These two imaging techniques can be used for environmental site characterization and environmental remediation monitoring. Technologies used for site characterization and monitoring have numerous and diverse applications within site clean-up and waste management operations.

  7. Site Characterization Work Plan for Gasbuggy, New Mexico

    Energy Technology Data Exchange (ETDEWEB)

    DOE/NV

    2000-12-14

    Project Gasbuggy was the first of three joint government-industry experiments conducted to test the effectiveness of nuclear explosives to fracture deeply buried, low-permeability natural gas reservoirs to stimulate production. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the Project Gasbuggy Site. Its goal is the collection of data in sufficient quantity and quality to determine current site conditions, support a risk assessment for the site surfaces, and evaluate if further remedial action is required to achieve permanent closure of the site that is both protective of human health and the environment. The Gasbuggy Site is located approximately 55 air miles east of Farmington, New Mexico, in Rio Arriba County within the Carson National Forest in the northeast portion of the San Juan Basin. Historically, Project Gasbuggy consisted of the joint government-industry detonation of a nuclear device on December 10, 1967, followed by reentry drilling and gas production testing and project evaluation activities in post-detonation operations from 1967 to 1976. Based on historical documentation, no chemical release sites other than the mud pits were identified; additionally, there was no material buried at the Gasbuggy Site other than drilling fluids and construction debris. Although previous characterization and restoration activities including sensitive species surveys, cultural resources surveys, surface geophysical surveys, and limited soil sampling and analysis were performed in 1978 and again in 2000, no formal closure of the site was achieved. Also, these efforts did not adequately address the site's potential for chemical contamination at the surface/shallow subsurface ground levels or the subsurface hazards for potential migration outside of the current site subsurface intrusion restrictions. Additional investigation

  8. Triad Issue Paper: Using Geophysical Tools to Develop the Conceptual Site Model

    Science.gov (United States)

    This technology bulletin explains how hazardous-waste site professionals can use geophysical tools to provide information about subsurface conditions to create a more representative conceptual site model (CSM).

  9. Determining the Performance of an Arid Zone Radioactive Waste Site Through Site Characterization, Modeling, and Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    B. L. Dozier; D. G. Levitt; M. J. Sully; and C. F. Lohrstorfer

    1999-03-09

    A strategy of site characterization, modeling, and monitoring are used to evaluate the performance of an interim cover at a low-level radioactive waste management site. The soil water migration papthway must be evaluated to assure the long-term isolation of low-level radioactive waste. Water balance studies using precision weighing lysimeters have been conducted for five years near the radioactive waste site ath the Nevada Test Site. The numerical flow models UNSAT-H and HYDRUS-2D were tested using the weighing lysimeter data and then used to evaluate various cover design issues including cover thickness, presence of vegetation, and monitoring system design.

  10. A field guide for well site geologists: Cable tool drilling

    Energy Technology Data Exchange (ETDEWEB)

    Last, G.V.; Liikala, T.L.

    1987-12-01

    This field is intended for use by Pacific Northwest Laboratory well site geologists who are responsible for data collection during the drilling and construction of monitoring wells on the Hanford Site. This guide presents standardized methods for geologic sample collection and description, and well construction documentation. 5 refs., 5 figs., 2 tabs.

  11. Ecological sites: A useful tool for land management

    Science.gov (United States)

    Alicia N. Struckhoff; Douglas Wallace; Fred. Young

    2017-01-01

    Developing ecological sites in Missouri is a multiagency, multidiscipline effort led by the Missouri Department of Conservation and the U.S. Department of Agriculture (USDA) Natural Resources Conservation Service. The methodology developed in Missouri has recently served as a model for ecological site development across the country and has aided in an initiative to...

  12. Hanford Site National Environmental Policy Act (NEPA) Characterization. Revision 5

    Energy Technology Data Exchange (ETDEWEB)

    Cushing, C.E. [ed.

    1992-12-01

    This fifth revision of the Hanford Site National Environmental Policy (NEPA) Characterization presents current environmental data regarding the Hanford Site and its immediate environs. This information is intended for use in preparing Site-related NEPA documentation. Information is presented on climate and meteorology, geology and hydrology, ecology, history and archaeology, socioeconomics, land use, and noise levels, prepared by Pacific Northwest Laboratory (PNL) staff. Models are described that are to be used in simulating realized or potential impacts from nuclear materials at the Hanford Site. Included are models of radionuclide transport in groundwater and atmospheric pathways, and of radiation dose to populations via all known pathways from known initial conditions. Federal and state regulations, DOE orders and permits, and environmental standards directly applicable for the NEPA documents at the Hanford Site, are provided.

  13. Hanford Site National Environmental Policy Act (NEPA) Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Cushing, C.E. (ed.)

    1992-12-01

    This fifth revision of the Hanford Site National Environmental Policy (NEPA) Characterization presents current environmental data regarding the Hanford Site and its immediate environs. This information is intended for use in preparing Site-related NEPA documentation. Information is presented on climate and meteorology, geology and hydrology, ecology, history and archaeology, socioeconomics, land use, and noise levels, prepared by Pacific Northwest Laboratory (PNL) staff. Models are described that are to be used in simulating realized or potential impacts from nuclear materials at the Hanford Site. Included are models of radionuclide transport in groundwater and atmospheric pathways, and of radiation dose to populations via all known pathways from known initial conditions. Federal and state regulations, DOE orders and permits, and environmental standards directly applicable for the NEPA documents at the Hanford Site, are provided.

  14. New tools in cybertherapy: the VEPSY web site.

    Science.gov (United States)

    Castelnuovo, Gianluca; Buselli, Claudio; De Ferrari, Roberta; Gaggioli, Andrea; Mantovani, Fabrizia; Molinari, Enrico; Villamira, Marco; Riva, Giuseppe

    2004-01-01

    In the last years the rapid development of the Internet and new communication technologies has had a great impact on psychology and psychotherapy. Psychotherapists seem to rely with more and more interest on the new technological tools such as videophone, audio and video chat, e-mail, SMS and the new Instant Messaging Tools (IMs). All these technologies outline a stimulating as well as complex scenario: in order to effectively exploit their potential, it is important to study which is the possible role played by the Internet-based tools inside a psychotherapeutic iter. Could the technology substitute the health care practitioners or are these tools only a resource in addition to the traditional ones in the therapist's hand? The major aim of this chapter is to provide a framework for the integration of old and new tools in mental health care. Different theoretical positions about the possible role played by e-therapy are reported showing the possible changes that psychotherapy will necessarily face in a cyber setting. The VEPSY website, an integration of different Internet-based tools developed within the VEPSY UPDATED Project, is described as an example of clinical application matching between old (and functional) practices with new (and promising) media for the treatment of different mental disorders. A rationale about the possible scenarios for the use of the VEPSY website in the clinical process is provided.

  15. Site characterization of the national seismic network of Italy

    Science.gov (United States)

    Bordoni, Paola; Pacor, Francesca; Cultrera, Giovanna; Casale, Paolo; Cara, Fabrizio; Di Giulio, Giuseppe; Famiani, Daniela; Ladina, Chiara; PIschiutta, Marta; Quintiliani, Matteo

    2017-04-01

    The national seismic network of Italy (Rete Sismica Nazionale, RSN) run by Istituto Nazionale di Geofisica e Vulcanologia (INGV) consists of more than 400 seismic stations connected in real time to the institute data center in order to locate earthquakes for civil defense purposes. A critical issue in the performance of a network is the characterization of site condition at the recording stations. Recently INGV has started addressing this subject through the revision of all available geological and geophysical data, the acquisition of new information by means of ad-hoc field measurements and the analysis of seismic waveforms. The main effort is towards building a database, integrated with the other INGV infrastructures, designed to archive homogeneous parameters through the seismic network useful for a complete site characterization, including housing, geological, seismological and geotechnical features as well as the site class according to the European and Italian building codes. Here we present the ongoing INGV activities.

  16. Site characterization plan: Yucca Mountain Site, Nevada Research and Development Area, Nevada: Volume 9, Index

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-12-01

    This site characterization plan (SCP) has been developed for the candidate repository site at Yucca Mountain in the State of Nevada. The SCP includes a description of the Yucca Mountain site (Chapters 1-5), a conceptual design for the repository (Chapter 6), a description of the packaging to be used for the waste to be emplaced in the repository (Chapter 7), and a description of the planned site characterization activities (Chapter 8). The schedules and milestones presented in Sections 8.3 and 8.5 of the SCP were developed to be consistent with the June 1988 draft Amendment to the DOE`s Mission Plan for the Civilian Radioactive Waste Management Program. The five month delay in the scheduled start of exploratory shaft construction that was announced recently is not reflected in these schedules.

  17. SITE CHARACTERIZATION AND SELECTION GUIDELINES FOR GEOLOGICAL CARBON SEQUESTRATION

    Energy Technology Data Exchange (ETDEWEB)

    Friedmann, S J

    2007-08-31

    Carbon capture and sequestration (CCS) is a key technology pathway to substantial reduction of greenhouse gas emissions for the state of California and the western region. Current estimates suggest that the sequestration resource of the state is large, and could safely and effectively accept all of the emissions from large CO2 point sources for many decades and store them indefinitely. This process requires suitable sites to sequester large volumes of CO2 for long periods of time. Site characterization is the first step in this process, and the state will ultimately face regulatory, legal, and technical questions as commercial CCS projects develop and commence operations. The most important aspects of site characterizations are injectivity, capacity, and effectiveness. A site can accept at a high rate a large volume of CO2 and store it for a long time is likely to serve as a good site for geological carbon sequestration. At present, there are many conventional technologies and approaches that can be used to estimate, quantify, calculate, and assess the viability of a sequestration site. Any regulatory framework would need to rely on conventional, easily executed, repeatable methods to inform the site selection and permitting process. The most important targets for long-term storage are deep saline formations and depleted oil and gas fields. The primary CO2 storage mechanisms for these targets are well understood enough to plan operations and simulate injection and long-term fate of CO2. There is also a strong understanding of potential geological and engineering hazards for CCS. These hazards are potential pathway to CO2 leakage, which could conceivably result in negative consequences to health and the environmental. The risks of these effects are difficult to quantify; however, the hazards themselves are sufficiently well understood to identify, delineate, and manage those risks effectively. The primary hazard elements are wells and faults, but may include other

  18. [Environmental characterization of the National Contaminated Sites in SENTIERI project].

    Science.gov (United States)

    Musmeci, L; Bellino, M; Falleni, F; Piccardi, A

    2011-01-01

    The concept of "polluted site" was firstly introduced in Italy with the definition of "environmental high risk areas" (Rule 349/86). Later, the decree 471/99 stated that a site is considered polluted if the concentration of even just one index pollutant in anyone of the matrices (soil or subsoil, surface or ground waters) exceeds the allowable threshold limit concentration. The boundaries of Italian polluted sites (IPS) were defined (Decree 152/06) on the basis of health, environmental and social criteria. SENTIERI Project includes 44 out of the 57 sites comprised in the "National environmental remediation program"; they correspond to the largest national industrial agglomerates. For each site, characterization data were collected, classified and arranged in tables. A great part of collected data came also from the environmental remediation programmes planned for the sites. These plans show that characterization and risk assessment activities were mainly undertaken for private industrial areas, as they were considered source of pollution. On the other hand, municipal and/or green and agricultural areas included in IPSs were poorly studied. Therefore, it is difficult to assess the exposure of the populations living inside and/or near the IPSs. The most probable population exposure come from the contamination of ground waters utilized for irrigation, or industrial emissions. For a description of SENTIERI, refer to the 2010 Supplement of Epidemiology & Prevention devoted to SENTIERI Project.

  19. Characterization of biogas bibliography measures on sites; Caracterisation des Biogaz bibliographie mesures sur sites

    Energy Technology Data Exchange (ETDEWEB)

    Poulleau, J.

    2002-10-15

    The aim of this study is to define the pollutants emissions related to the combustion of biogas of different sources: motors, furnaces, flares...The project is presented in three parts: a bibliographic study on the chemical characterization of the biogas, a first series of measures on production sites and a second series of measures on a site of valorization and destruction of biogas. (A.L.B.)

  20. Hanford Site National Environmental Policy Act (NEPA) characterization. Revision 6

    Energy Technology Data Exchange (ETDEWEB)

    Cushing, C.E. [ed.; Baker, D.A.; Chamness, M.A. [and others

    1994-08-01

    This sixth revision of the Hanford Site National Environmental Policy (NEPA) Characterization presents current environmental data regarding the Hanford Site and its immediate environs. This information is intended for use in preparing Site-related NEPA documentation. Chapter 4.0 summarizes up-to-date information on climate and meteorology, geology and hydrology, ecology, history and archaeology, socioeconomics, land use, and noise levels prepared by Pacific Northwest Laboratory (PNL) staff. More detailed data are available from reference sources cited or from the authors; Chapter 5.0 has been significantly updated from the fifth revision. It describes models, including their principal underlying assumptions, that are to be used in simulating realized or potential impacts from nuclear materials at the Hanford Site. Included are models of radionuclide transport in groundwater and atmospheric pathways, and of radiation dose to populations via all known pathways from known initial conditions; The updated Chapter 6.0 provides the preparer with the federal and state regulations, DOE orders and permits, and environmental standards directly applicable to the NEPA documents on the Hanford Site, following the structure of Chapter 4.0. No conclusions or recommendations are given in this report. Rather, it is a compilation of information on the Hanford Site environment that can be utilized directly by Site contractors. This information can also be used by any interested individual seeking baseline data on the Hanford Site and its past activities by which to evaluate projected activities and their impacts.

  1. Hanford Site National Environmental Policy Act (NEPA) characterization. Revision 7

    Energy Technology Data Exchange (ETDEWEB)

    Cushing, C.E. [ed.; Baker, D.A.; Chamness, M.A. [and others

    1995-09-01

    This seventh revision of the Hanford Site National Environmental Policy (NEPA) Characterization presents current environmental data regarding the Hanford Site and its immediate environs. This information is intended for use in preparing Site-related NEPA documentation. Chapter 4.0 summarizes up-to-date information on climate and meteorology, geology, hydrology, environmental monitoring, ecology, history and archaeology, socioeconomics, land use, and noise levels prepared by Pacific Northwest Laboratory (PNL) staff. More detailed data are available from reference sources cited or from the authors. Chapter 5.0 was not updated from the sixth revision (1994). It describes models, including their principal underlying assumptions, that are to be used in simulating realized or potential impacts from nuclear materials at the Hanford Site. Included are models of radionuclide transport in groundwater and atmospheric pathways, and of radiation dose to populations via all known pathways from known initial conditions. The updated Chapter 6.0 provides the preparer with the federal and state regulations, DOE Orders and permits, and environmental standards directly applicable to the NEPA documents on the Hanford Site, following the structure of Chapter 4.0. No conclusions or recommendations are given in this report. Rather, it is a compilation of information on the Hanford Site environment that can be used directly by Site contractors. This information can also be used by any interested individual seeking baseline data on the Hanford Site and its past activities by which to evaluate projected activities and their impacts.

  2. Hanford Site National Environmental Policy Act (NEPA) characterization. Revision 9

    Energy Technology Data Exchange (ETDEWEB)

    Neitzel, D.A. [ed.; Bjornstad, B.N.; Fosmire, C.J. [and others

    1997-08-01

    This ninth revision of the Hanford Site National Environmental Policy Act (NEPA) Characterization presents current environmental data regarding the hanford Site and its immediate environs. This information is intended for use in preparing Chapters 4 and 6 in Hanford Site-related NEPA documents. Chapter 4.0 (Affected Environment) includes information on climate and meteorology, geology, hydrology, ecology, cultural, archaeological and historical resources, socioeconomics, and noise. Chapter 6.0 (Statutory and Regulatory Requirements) provides the preparer with the federal and state regulations, DOE directives and permits, and environmental standards directly applicable to the NEPA documents on the Hanford Site. Not all of the sections have been updated for this revision. The following lists the updated sections: climate and meteorology; ecology (threatened and endangered species section only); culture, archaeological, and historical resources; socioeconomics; all of Chapter 6.

  3. Your School's Web Site-A Powerful Tool for Marketing.

    Science.gov (United States)

    Say, Michael W.; Collier, Karen J.; Hoya, Charlotte, G.

    2001-01-01

    A successful marketing plan requires a conceptual framework, the ability to target an audience effectively, and the strategy for positioning the school organization appropriately. A website can be a powerful marketing tool if it focuses on what users want and provides it in an organized, accessible fashion. (MLH)

  4. Final Hanford Site Transuranic (TRU) Waste Characterization QA Project Plan

    Energy Technology Data Exchange (ETDEWEB)

    GREAGER, T.M.

    2000-12-06

    The Quality Assurance Project Plan (QAPjP) has been prepared for waste characterization activities to be conducted by the Transuranic (TRU) Project at the Hanford Site to meet requirements set forth in the Waste Isolation Pilot Plan (WIPP) Hazardous Waste Facility Permit, 4890139088-TSDF, Attachment B, including Attachments B1 through B6 (WAP) (DOE, 1999a). The QAPjP describes the waste characterization requirements and includes test methods, details of planned waste sampling and analysis, and a description of the waste characterization and verification process. In addition, the QAPjP includes a description of the quality assurance/quality control (QA/QC) requirements for the waste characterization program. Before TRU waste is shipped to the WIPP site by the TRU Project, all applicable requirements of the QAPjP shall be implemented. Additional requirements necessary for transportation to waste disposal at WIPP can be found in the ''Quality Assurance Program Document'' (DOE 1999b) and HNF-2600, ''Hanford Site Transuranic Waste Certification Plan.'' TRU mixed waste contains both TRU radioactive and hazardous components, as defined in the WLPP-WAP. The waste is designated and separately packaged as either contact-handled (CH) or remote-handled (RH), based on the radiological dose rate at the surface of the waste container. RH TRU wastes are not currently shipped to the WIPP facility.

  5. Hanford Site National Environmental Policy Act (NEPA) characterization. Revision 8

    Energy Technology Data Exchange (ETDEWEB)

    Neitzel, D.A. [ed.; Bjornstad, B.N.; Fosmire, C.J.; Fowler, R.A. [and others

    1996-08-01

    This eighth revision of the Hanford Site National Environmental Policy Act (NEPA) Characterization presents current environmental data regarding the Hanford Site and its immediate environs. This information is intended for use in preparing Chapters 4 and 6 in Hanford Site-related NEPA documents. Chapter 4 (Affected Environment) includes information on climate and meteorology, geology, hydrology, ecology, historical, archaeological and cultural resources, socioeconomics, and noise. Chapter 6 (Statutory and Regulatory Requirements) provides the preparer with the federal and state regulations, DOE directives and permits, and environmental standards directly applicable to the NEPA documents on the Hanford Site. The following sections were updated in this revision: climate and meteorology; ecology (threatened and endangered species section only); historical; archaeological and cultural resources; and all of chapter 6. No conclusions or recommendations are given in this report. Rather, it is a compilation of information on the Hanford Site environment that can be used directly by Site contractors. This information can also be used by any interested individual seeking baseline data on the hanford Site and its past activities by which to evaluate projected activities and their impacts.

  6. Digital Capture and Fabrication Tools for Interpretation of Historic Sites

    Science.gov (United States)

    Ackerman, A.; Glekas, E.

    2017-08-01

    Historic sites and the narratives they produce can have a lasting impact on the community through public engagement and education. However, when these sites are neglected and lost over time, opportunities to engage the public with the history of these places is lost with them. The interpretation of heritage that has been lost or forgotten is an emerging trend in humanities studies. This trend, in combination with technological advancements in digital media and representation, presents an innovative opportunity for historic preservation professionals to create new paths for public engagement. This paper discusses applications of photogrammetry, 3D modeling, and digital fabrication in digitally reconstructing interpretive models of the Larz Anderson Estate (now Larz Anderson Park). This site has changed dramatically through its transition from a private estate to a public park and recreation area, with few remnants of the original estate remaining extant. The above stated use of digital strategies aims to create digital and physical models of the estate's change over time, with the aim of interpreting the site's lost heritage for the public. Combining existing archival research and heritage documentation methods with these digital representation techniques tells the story of a place that no longer exists.

  7. DIGITAL CAPTURE AND FABRICATION TOOLS FOR INTERPRETATION OF HISTORIC SITES

    Directory of Open Access Journals (Sweden)

    A. Ackerman

    2017-08-01

    Full Text Available Historic sites and the narratives they produce can have a lasting impact on the community through public engagement and education. However, when these sites are neglected and lost over time, opportunities to engage the public with the history of these places is lost with them. The interpretation of heritage that has been lost or forgotten is an emerging trend in humanities studies. This trend, in combination with technological advancements in digital media and representation, presents an innovative opportunity for historic preservation professionals to create new paths for public engagement. This paper discusses applications of photogrammetry, 3D modeling, and digital fabrication in digitally reconstructing interpretive models of the Larz Anderson Estate (now Larz Anderson Park. This site has changed dramatically through its transition from a private estate to a public park and recreation area, with few remnants of the original estate remaining extant. The above stated use of digital strategies aims to create digital and physical models of the estate’s change over time, with the aim of interpreting the site's lost heritage for the public. Combining existing archival research and heritage documentation methods with these digital representation techniques tells the story of a place that no longer exists.

  8. A tool for identifying potential Eucalyptus nitens seed orchard sites ...

    African Journals Online (AJOL)

    Shy seed production in orchards of Eucalyptus nitens is a major barrier to the deployment of genetic gain in South African plantations. A machine learning method was used to identify optimal sites for the establishment of E. nitens seed orchards within the plantation forestry landscape of the summer rainfall region of South ...

  9. Metrology tools for EUV-source characterization and optimization

    Science.gov (United States)

    Missalla, Thomas; Schuermann, Max C.; Lebert, Rainer; Wies, Christian; Juschkin, Larissa; Klein, Roman M.; Scholze, Frank; Ulm, Gerhard; Egbert, Andre; Tkachenko, Boris; Chichkov, Boris N.

    2004-05-01

    The development of suitable radiation sources for extreme ultraviolet lithography (EUVL) is a major challenge. For the optimization of these sources and for the determination of the parameters needed for the system design and the system integration these sources have to be characterized in terms of the absolute in-band power, the spectral distribution in the EUV spectral region and the out-of-band spectral regions, the spatial distribution of the emitting volume and the angular distribution of the emission. For improving the lifetime of such sources, generally accepted as one key risk with EUVL, another task, the debris emitted from sources under development has to be investigated. Therefore, JENOPTIK Mikrotechnik GmbH is co-operating with the Laser Laboratorium Goettingen, the Physikalisch-Technische Bundesanstalt (PTB) and the AIXUV GmbH in developing ready-for-use metrology tools for EUVL source characterization and optimization. The set of the tools employed for EUV-source characterization is presented in detail as well as concepts for calibration and measurement procedures.

  10. Boron containing combination tool coatings-characterization and application tests

    Energy Technology Data Exchange (ETDEWEB)

    Keunecke, M. [Fraunhofer Institute for Surface Engineering and Thin Films (IST), Braunschweig (Germany)]. E-mail: keunecke@ist.fraunhofer.de; Bewilogua, K. [Fraunhofer Institute for Surface Engineering and Thin Films (IST), Braunschweig (Germany); Wiemann, E. [Institute for Machine Tools and Factory Management, Technical University Berlin (Germany); Weigel, K. [Fraunhofer Institute for Surface Engineering and Thin Films (IST), Braunschweig (Germany); Wittorf, R. [Fraunhofer Institute for Surface Engineering and Thin Films (IST), Braunschweig (Germany); Thomsen, H. [Fraunhofer Institute for Surface Engineering and Thin Films (IST), Braunschweig (Germany)

    2006-01-03

    The requirements for durable tool coatings continuously increase. In many cases, tool coatings combining different phases or several layers could provide an improvement in tool life. The broad range of mechanical properties of materials in the B-C-N and Ti-B-N ternary systems, from very soft to superhard, presents many possibilities to generate various combination coatings. Such coatings were prepared using reactive sputter techniques with different target materials. An outstanding example is a superhard 3 {mu}m thick coating system with a 0.5 to 0.8 {mu}m thick cBN top layer deposited on cutting inserts. Soft coatings like hexagonal boron nitride were found to be essential for machining operations under dry conditions. The coatings were characterized with respect to hardness, abrasive wear rate and friction coefficients. The correlation between properties and composition was revealed. Application test results of B-C-N and Ti-B-N coating systems on tools obtained under near production conditions will be reported. Specifically, turning tests performed with cemented carbide cutting inserts coated with a superhard coating system with a cBN top layer will be discussed.

  11. Geological characterization of contaminated sites in urban areas (Denmark)

    DEFF Research Database (Denmark)

    Andersen, Theis Raaschou; Nissen, Randi Warncke; Poulsen, Søren Erbs

    In Denmark, contaminations from industry and farming represent a significant threat to groundwater resources. Hence there is a focus on identifying and locating these contaminated places. Once located, contaminations are mapped and monitored and remediation efforts are undertaken. Remediation is ......, can minimize the uncertainties on predictions of the fate of the contaminant. Based on the work, we were able to pinpoint the best strategies and solutions for future remediation efforts at the two sites....... in the projections on the fate of the contaminant. From two contaminated sites located around the city of Horsens, Denmark we carry out a geological characterization. The two sites are situated in urban areas. Existing data from the two field sites includes only lithological profiles from boreholes. In order...... geological models of the two sites were constructed. The 3D geological models will serve as a basis for simulating groundwater flow and contaminant transport at the field sites. The study demonstrates how detailed information about the geological setting in conjunction with contaminant transport modelling...

  12. Yucca Mountain Site Characterization Project: Technical Data Catalog quarterly supplement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-03-31

    The March 21, 1993, Department of Energy (DOE)/Nuclear Regulatory Commission (NRC) Site-Specific Procedural Agreement for Geologic Repository Site Investigation and Characterization Program requires the DOE to develop and maintain a catalog of data which will be updated and provided to the NRC at least quarterly. This catalog is to include a description of the data; the time (date), place, and method of acquisition; and where it may be examined. The Yucca Mountain Site Characterization Project (YMP) Technical Data Catalog is published and distributed in accordance with the requirements of the Site-Specific Agreement. The YMP Technical Data Catalog is a report based on reference information contained in the YMP Automated Technical Data Tracking System (ATDT). The reference information is provided by Participants for data acquired or developed in support of the YMP. The Technical Data Catalog is updated quarterly and published in the month following the end of each quarter. A complete revision to the Catalog is published at the end of each fiscal year. Supplements to the end-of-year edition are published each quarter. These supplements provide information related to new data items not included in previous quarterly updates and data items affected by changes to previously published reference information. The Technical Data Catalog, dated September 30, 1993, should be retained as the baseline document for the supplements until the end-of-year revision is published and distributed in October 1994.

  13. Yucca Mountain Site Characterization Project technical data catalog: Quarterly supplement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    The Department of Energy (DOE)/Nuclear Regulatory Commission (NRC) Site-Specific Procedural Agreement for Geologic Repository Site Investigation and Characterization Program requires the DOE to develop and maintain a catalog of data which will be updated and provided to the NRC at least quarterly. This catalog is to include a description of the data; the time (date), place, and method of acquisition; and where the data may be examined. The Yucca Mountain Site Characterization Project (YMP) Technical Data Catalog is published and distributed-in accordance with the requirements of the Site-Specific Agreement. The YMP Technical Data Catalog is a report based on reference information contained in the YMP Automated Technical Data Tracking System (ATDT). The reference information is provided by Participants for data acquired or developed in support of the YMP. The Technical Data Catalog is updated quarterly and distributed in the month following the end of each quarter. A complete revision to the catalog is published at the end of each fiscal year. Supplements to the end-of-year edition are published each quarter. These supplements provide information related to new data items not included in previous quarterly updates and data items affected by changes to previously published reference information. The Technical Data Catalog, dated September 30, 1994, should be retained as the baseline document for the supplements until the end-of-year revision is published and distributed in October 1995.

  14. Yucca Mountain Site Characterization Project technical data catalog quarterly supplement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    The Department of Energy (DOE)/Nuclear Regulatory Commission (NRC) Site-Specific Procedural Agreement for Geologic Repository Site Investigation and Characterization Program requires the DOE to develop and maintain a catalog of data which will be updated and provided to the NRC at least quarterly. This catalog is to include a description of the data; the time (date), place, and method of acquisition; and where the data may be examined. The Yucca Mountain Site Characterization Project (YMP) Technical Data Catalog is published and distributed in accordance with t requirements of the Site-Specific Agreement. The YMP Technical Data Catalog is a report based on reference information contained in the YMP Automated Technical Data Tracking System (ATDT). The reference information is provided by Participants for data acquired or developed in support of the YMP. The Technical Data Catalog is updated quarterly and distributed in the month following the end of each quarter. A complete revision to the catalog is published at the end of each fiscal year. Supplements to the end-of-year edition are published each quarter. These supplements provide information related to new data items not included in previous quarterly updates and data items affected by changes to@ previously published reference information. The Technical Data Catalog, dated September 30, 1994, should be retained as the baseline document for the supplements until the end-of-year revision is published and distributed in October 1995.

  15. Yucca Mountain Site Characterization Project Technical Data Catalog (Quarterly supplement)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-12-31

    The March 21, 1993, Department of Energy (DOE)/Nuclear Regulatory Commission (NRC) Site-Specific Procedural Agreement for Geologic Repository Site Investigation and Characterization Program requires the DOE to develop and maintain a catalog of data which will be updated and provided to the NRC at least quarterly. This catalog is to include a description of the data; the time (date), place, and method of acquisition; and where it may be examined. The Yucca Mountain Site Characterization Project (YMP) Technical Data Catalog is published and distributed in accordance with the requirements of the Site-Specific Agreement. The YMP Technical Data Catalog is a report based on reference information contained in the YMP Automated Technical Data Tracking System (ATDT). The reference information is provided by Participants for data acquired or developed in support of the YMP. The Technical Data Catalog is updated quarterly and published in the month following the end of each quarter. A complete revision to the Catalog is published at the end of each fiscal year. Supplements to the end-of-year edition are published each quarter. These supplements provide information related to new data items not included in previous quarterly updates and data items affected by changes to previously published reference information. The Technical Data Catalog, dated September 30, 1993, should be retained as the baseline document for the supplements until the end-of-year revision is published and distributed in October 1994.

  16. Site Characterization Work Plan for Gnome-Coach Site, New Mexico

    Energy Technology Data Exchange (ETDEWEB)

    DOE/NV

    2001-02-13

    Project Gnome was the first nuclear experiment conducted under the U.S. Atomic Energy Commission (AEC), predecessor to the U.S. Department of Energy (DOE), Plowshare Program. Gnome was part of a joint government-industry experiment focused on developing nuclear devices exclusively for peaceful purposes. The intent of the Gnome experiment was to evaluate the effects of a nuclear detonation in a salt medium. Historically, Project Gnome consisted of a single detonation of a nuclear device on December 10, 1961. Since the Gnome detonation, the AEC/DOE has conducted surface restoration, site reconnaissance, and decontamination and decommissioning activities at the site. In addition, annual groundwater sampling is performed under a long-term hydrological monitoring program begun in 1980. Coach, an experiment to be located near the Gnome project, was initially scheduled for 1963. Although construction and rehabilitation were completed for Coach, the experiment was canceled and never executed. Known collectively as Project Gnome-Coach, the site is situated within the Salado Formation approximately 25 miles east of Carlsbad, New Mexico, in Eddy County, and is comprised of nearly 680 acres, of which 60 acres are disturbed from the combined AEC/DOE operations. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the project. The subsurface at the Gnome-Coach site has two contaminant sources that are fundamentally different in terms of both their stratigraphic location and release mechanism. The goal of this characterization is to collect data of sufficient quantity and quality to establish current site conditions and to use the data to identify and evaluate if further action is required to protect human health and the environment and achieve permanent closure of the site. The results of these activities will be presented in a subsequent corrective

  17. Site Characterization Work Plan for the Gnome-Coach Site, New Mexico (Rev. 1, January 2002)

    Energy Technology Data Exchange (ETDEWEB)

    U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office (NNSA/NV)

    2002-01-14

    Project Gnome was the first nuclear experiment conducted under the U.S. Atomic Energy Commission (AEC), predecessor to the U.S. Department of Energy (DOE), Plowshare Program. The Plowshare Program focused on developing nuclear devices exclusively for peaceful purposes. The intent of the Gnome experiment was to evaluate the effects of a nuclear detonation in a salt medium. Historically, Project Gnome consisted of a single detonation of a nuclear device on December 10, 1961 with the Salado Formation. Since the Gnome detonation, the AEC/DOE has conducted surface restoration, site reconnaissance, and decontamination and decommissioning activities at the site. In addition, annual groundwater sampling is performed under a long-term hydrological monitoring program begun in 1972. Coach, an experiment to be located near the Gnome project, was initially scheduled for 1963. Although construction and rehabilitation were completed for Coach, the experiment was canceled and never executed. Known collectively as Project Gnome-Coach, the site is located approximately 25 miles east of Carlsbad, New Mexico, in Eddy County, and is comprised of nearly 680 acres, of which approximately 60 acres are disturbed from the combined AEC/DOE operations. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the project. The subsurface at the Gnome-Coach site has two contaminant sources that are fundamentally different in terms of both their stratigraphic location and release mechanism. The goal of this characterization is to collect data of sufficient quantity and quality to establish current site conditions and to use the data to identify and evaluate if further action is required to protect human health and the environment and achieve permanent closure of the site. The results of these activities will be presented in a subsequent corrective action decision document.

  18. Site characterization and monitoring data from Area 5 Pilot Wells, Nevada Test Site, Nye County, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-02-01

    The Special Projects Section (SPS) of Reynolds Electrical & Engineering Co., Inc. (REECO) is responsible for characterizing the subsurface geology and hydrology of the Area 5 Radioactive Waste Management Site (RWMS) at the Nevada Test Site (NTS) for the US Department of Energy, Nevada Operations Office (DOE/NV), Environmental Restoration and Waste Management Division, Waste Operations Branch. The three Pilot Wells that comprise the Pilot Well Project are an important part of the Area 5 Site Characterization Program designed to determine the suitability of the Area 5 RWMS for disposal of low-level waste (LLW), mixed waste (MW), and transuranic waste (TRU). The primary purpose of the Pilot Well Project is two-fold: first, to characterize important water quality and hydrologic properties of the uppermost aquifer; and second, to characterize the lithologic, stratigraphic, and hydrologic conditions which influence infiltration, redistribution, and percolation, and chemical transport through the thick vadose zone in the vicinity of the Area 5 RWMS. This report describes Pilot Well drilling and coring, geophysical logging, instrumentation and stemming, laboratory testing, and in situ testing and monitoring activities.

  19. FY 93 site characterization status report and data package for the carbon tetrachloride site

    Energy Technology Data Exchange (ETDEWEB)

    Rohay, V.J. [Westinghouse Hanford Co., Richland, WA (United States)

    1993-09-28

    This report provides the status and accomplishments from fiscal year site characterization activities conducted as part of the 200 West Area Carbon Tetrachloride Expedited Response Action and the Volatile Organic Compounds - Arid Integrated Demonstration. The report includes or references all available raw data collected as part of these tasks. During fiscal year 1993, the 200 West Area Carbon Tetrachloride Expedited Response Action and the Volatile Organic Compounds - Arid Integrated Demonstration programs focused on the carbon tetrachloride plume in the unsaturated zone underlying the 200 West Area at the Hanford Site in southeast Washington.

  20. Hanford Site National Evnironmental Policy Act (NEPA) characterization

    Energy Technology Data Exchange (ETDEWEB)

    Cushing, C.E. (ed.)

    1991-12-01

    This fourth revision of the Hanford Site National Environmental Policy (NEPA) Characterization presents current environmental data regarding the Hanford Site and its immediate environs. This information is intended for use in preparing Site-related NEPA documentation. In Chapter 4.0 are presented summations of up-to-date information about climate and meteorology, geology and hydrology, ecology, history and archaeology, socioeconomics, land use, and noise levels. Chapter 5.0 describes models, including their principal assumptions, that are to be used in simulating realized or potential impacts from nuclear materials at the Hanford Site. Included are models of radionuclides transport in groundwater and atmospheric pathways, and of radiation dose to populations via all known pathways from known initial conditions. Chapter 6.0 provides the preparer with the federal and state regulations, DOE orders and permits, and environmental standards directly applicable for environmental impact statements for the Hanford Site, following the structure Chapter 4.0. NO conclusions or recommendations are given in this report.

  1. Hanford Site National Evnironmental Policy Act (NEPA) characterization. Revision 4

    Energy Technology Data Exchange (ETDEWEB)

    Cushing, C.E. [ed.

    1991-12-01

    This fourth revision of the Hanford Site National Environmental Policy (NEPA) Characterization presents current environmental data regarding the Hanford Site and its immediate environs. This information is intended for use in preparing Site-related NEPA documentation. In Chapter 4.0 are presented summations of up-to-date information about climate and meteorology, geology and hydrology, ecology, history and archaeology, socioeconomics, land use, and noise levels. Chapter 5.0 describes models, including their principal assumptions, that are to be used in simulating realized or potential impacts from nuclear materials at the Hanford Site. Included are models of radionuclides transport in groundwater and atmospheric pathways, and of radiation dose to populations via all known pathways from known initial conditions. Chapter 6.0 provides the preparer with the federal and state regulations, DOE orders and permits, and environmental standards directly applicable for environmental impact statements for the Hanford Site, following the structure Chapter 4.0. NO conclusions or recommendations are given in this report.

  2. Wavelet Packet Decomposition to Characterize Injection Molding Tool Damage

    Directory of Open Access Journals (Sweden)

    Tomaž Kek

    2016-02-01

    Full Text Available This paper presents measurements of acoustic emission (AE signals during the injection molding of polypropylene with new and damaged mold. The damaged injection mold has cracks induced by laser surface heat treatment. Standard test specimens were injection molded, commonly used for examining the shrinkage behavior of various thermoplastic materials. The measured AE burst signals during injection molding cycle are presented. For injection molding tool integrity prediction, different AE burst signals’ descriptors are defined. To lower computational complexity and increase performance, the feature selection method was implemented to define a feature subset in an appropriate multidimensional space to characterize the integrity of the injection molding tool and the injection molding process steps. The feature subset was used for neural network pattern recognition of AE signals during the full time of the injection molding cycle. The results confirm that acoustic emission measurement during injection molding of polymer materials is a promising technique for characterizing the integrity of molds with respect to damage, even with resonant sensors.

  3. Towards more accurate prediction of ubiquitination sites: a comprehensive review of current methods, tools and features.

    Science.gov (United States)

    Chen, Zhen; Zhou, Yuan; Zhang, Ziding; Song, Jiangning

    2015-07-01

    Protein ubiquitination is one of the most important reversible post-translational modifications (PTMs). In many biochemical, pathological and pharmaceutical studies on understanding the function of proteins in biological processes, identification of ubiquitination sites is an important first step. However, experimental approaches for identifying ubiquitination sites are often expensive, labor-intensive and time-consuming, partly due to the dynamics and reversibility of ubiquitination. In silico prediction of ubiquitination sites is potentially a useful strategy for whole proteome annotation. A number of bioinformatics approaches and tools have recently been developed for predicting protein ubiquitination sites. However, these tools have different methodologies, prediction algorithms, functionality and features, which complicate their utility and application. The purpose of this review is to aid users in selecting appropriate tools for specific analyses and circumstances. We first compared five popular webservers and standalone software options, assessing their performance on four up-to-date ubiquitination benchmark datasets from Saccharomyces cerevisiae, Homo sapiens, Mus musculus and Arabidopsis thaliana. We then discussed and summarized these tools to guide users in choosing among the tools efficiently and rapidly. Finally, we assessed the importance of features of existing tools for ubiquitination site prediction, ranking them by performance. We also discussed the features that make noticeable contributions to species-specific ubiquitination site prediction. © The Author 2014. Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  4. A radiological characterization of remediated tank battery sites.

    Science.gov (United States)

    Hebert, M B; Scott, L M; Zrake, S J

    1995-03-01

    Tank battery sites have historically been used for the initial processing of crude oil which separates water and sediment from the produced oil. Typically, one or more producing wells is connected to a tank battery site consisting of storage and separation tanks. Historical operating practices also included a production holding pit for increased separation of oil, water, and sediment. The sediment remaining in the pit is composed of an oily, viscous material called sludge. Under certain circumstances, this sludge may contain naturally occurring radioactive material. The methodology required for reclamation of the production holding pits consisted of removal of soil and sludge from the pits with controlled land-spreading to achieve biodegradation of the hydrocarbons. The purpose of this study was to perform a radiological characterization on representative tank battery sites that had been reclaimed in the above fashion. The average gamma radiation exposure rates encountered ranged from 2.1-7.2 pC kg-1 s-1. The average concentration of 226Ra for the tank battery sites ranged from 0.5-2.3, 0.5-2.8, and 0.3-3.2 Bq g-1 for soil depths of 0-15, 15-30, and 30-51 cm, respectively. Average radon flux measurements ranged from 29.7-211.8 mBq m-2 s-1. Measurements of the radon emanation coefficient of NORM ranged from 3-7%.

  5. Site characterization data for Solid Waste Storage Area 6

    Energy Technology Data Exchange (ETDEWEB)

    Boegly, W.J. Jr.

    1984-12-01

    Currently, the only operating shallow land burial site for low-level radioactive waste at the Oak Ridge National Laboratory (ORNL) is Solid Waste Storage Area No. 6 (SWSA-6). In 1984, the US Department of Energy (DOE) issued Order 5820.2, Radioactive Waste Management, which establishes policies and guidelines by which DOE manages its radioactive waste, waste by-products, and radioactively contaminated surplus facilities. The ORNL Operations Division has given high priority to characterization of SWSA-6 because of the need for continued operation under DOE 5820.2. The purpose of this report is to compile existing information on the geologic and hydrologic cond

  6. Assessment of multiple geophysical techniques for the characterization of municipal waste deposit sites

    Science.gov (United States)

    Gaël, Dumont; Tanguy, Robert; Nicolas, Marck; Frédéric, Nguyen

    2017-10-01

    In this study, we tested the ability of geophysical methods to characterize a large technical landfill installed in a former sand quarry. The geophysical surveys specifically aimed at delimitating the deposit site horizontal extension, at estimating its thickness and at characterizing the waste material composition (the moisture content in the present case). The site delimitation was conducted with electromagnetic (in-phase and out-of-phase) and magnetic (vertical gradient and total field) methods that clearly showed the transition between the waste deposit and the host formation. Regarding waste deposit thickness evaluation, electrical resistivity tomography appeared inefficient on this particularly thick deposit site. Thus, we propose a combination of horizontal to vertical noise spectral ratio (HVNSR) and multichannel analysis of the surface waves (MASW), which successfully determined the approximate waste deposit thickness in our test landfill. However, ERT appeared to be an appropriate tool to characterize the moisture content of the waste, which is of prior information for the organic waste biodegradation process. The global multi-scale and multi-method geophysical survey offers precious information for site rehabilitation studies, water content mitigation processes for enhanced biodegradation or landfill mining operation planning.

  7. Bioremediation demonstration on Kwajalein Island: Site characterization and on-site biotreatability studies

    Energy Technology Data Exchange (ETDEWEB)

    Siegrist, R.L.; Korte, N.E.; Pickering, D.A. (Oak Ridge National Lab., TN (United States)); Phelps, T.J. (Tennessee Univ., Knoxville, TN (United States))

    1991-09-01

    An environmental study was conducted during February 1991 on Kwajalein Island, a US Army Kwajalein Atoll (USAKA) Base in the Republic of the Marshall Islands (RMI). This study was undertaken for the US Department of Energy (DOE) Hazardous Waste Remedial Actions Program (HAZWRAP) acting in behalf of USAKA. The purpose of the study was to determine if selected locations for new construction on Kwajalein Island were contaminated by petroleum hydrocarbons as suspected and, if so, whether bioremediation appeared to be a feasible technology for environmental restoration. Two different sites were evaluated: (1) the site planned freshwater production facility and (2) a site adjacent to an aboveground diesel fuel storage tank. Within the proposed construction zone for the freshwater production facility (a.k.a desalination plant), total petroleum hydrocarbons (TPH) where either absent or at low levels. Characterization data for another potential construction site adjacent to an aboveground diesel fuel storage tank southeast of the old diesel power plant revealed high concentrations of diesel fuel in the soil and groundwater beneath the site. Results of this investigation indicate that there are petroleum-contaminated soils on Kwajalein Island and bioremediation appears to be a viable environmental restoration technique. Further experimentation and field demonstration are required to determine the design and operating conditions that provide for optimum biodegradation and restoration of the petroleum-contaminated soils. 17 refs., 7 figs., 26 figs.

  8. CHARACTERIZATION OF NEW TOOL STEEL FOR ALUMINUM EXTRUSION DIES

    Directory of Open Access Journals (Sweden)

    José Britti Bacalhau

    2014-06-01

    Full Text Available Aluminum extrusion dies are an important segment of application on industrial tools steels, which are manufactured in steels based on AISI H13 steel. The main properties of steels applied to extrusion dies are: wear resistance, impact resistance and tempering resistance. The present work discusses the characteristics of a newly developed hot work steel to be used on aluminum extrusion dies. The effects of Cr and Mo contents with respect to tempering resistance and the Al addition on the nitriding response have been evaluated. From forged steel bars, Charpy impact test and characterization via EPMA have been conducted. The proposed contents of Cr, Mo, and Al have attributed to the new VEX grade a much better tempering resistance than H13, as well as a deeper and harder nitrided layer. Due to the unique characteristics, this new steel provides an interesting alternative to the aluminum extrusion companies to increase their competitiveness.

  9. CCS Acceptability: Social Site Characterization and Advancing Awareness at Prospective Storage Sites in Poland and Scotland

    Directory of Open Access Journals (Sweden)

    Brunsting Suzanne

    2015-04-01

    Full Text Available This paper summarizes the work on the social dimension conducted within the EU FP7 SiteChar project. The most important aim of the research was to advance public awareness and draw lessons for successful public engagement activities when developing a CO2 storage permit application. To this end, social site characterization (e.g. representative surveys and public participation activities (focus conference were conducted at two prospective Carbon Capture and Storage (CCS sites: an onshore site in Poland and an offshore site in Scotland. The research consisted of four steps over a time period of 1.5 year, from early 2011 to mid-2012. The first step consisted of four related qualitative and quantitative research activities to provide a social characterization of the areas: desk research, stakeholder interviews, media analyses, and a survey among representative samples of the local community. The aim was to identify: stakeholders or interested parties; factors that may drive their perceptions of and attitudes towards CCS. Results were used to as input for the second step, in which a new format for public engagement named ‘focus conferences’ was tested at both sites involving a small sample of the local community. The third step consisted of making available generic as well as site-specific information to the general and local public, by: setting up a bilingual set of information pages on the project website suitable for a lay audience; organizing information meetings at both sites that were open to all who took interest. The fourth step consisted of a second survey among a new representative sample of the local community. The survey was largely identical to the survey in step 1 to enable the monitoring of changes in awareness, knowledge and opinions over time. Results provide insight in the way local CCS plans may be perceived by the local stakeholders, how this can be reliably assessed at early stage without raising unnecessary concerns, and how

  10. Site Characterization Plan: Uranium Stabilization through Polyphosphate Injection

    Energy Technology Data Exchange (ETDEWEB)

    Vermeul, Vince R.; Fruchter, Jonathan S.; Wellman, Dawn M.; Williams, Bruce A.; Williams, Mark D.

    2006-12-01

    An initial feasibility study of options to treat the uranium plume at the 300-FF-5 Operable Unit considered hydraulic containment, slurry wall containment, and groundwater extraction as potential remedial action technologies. None were selected for interim action, and reduction of contamination levels by natural processes was considered a viable alternative while source removal actions continued. Subsequent planning for a Phase III feasibility study focused on methods that would reduce the concentration of uranium in the aquifer, including multiple methods to immobilize uranium using chemical-based technologies. Based on an initial technology screening, the polyphosphate technology was identified as the best candidate to treat the for further evaluation and selected for treatability testing. The overall objective of the polyphosphate treatability test is to evaluate the efficacy of using polyphosphate injections to treat uranium contaminated groundwater in situ. The objective of the work elements included in this site characterization plan is to collect site-specific characterization data that will be needed to design and implement a field-scale demonstration of the technology.

  11. Hydrogeologic characterization of an arid zone Radioactive Waste Management Site

    Energy Technology Data Exchange (ETDEWEB)

    Ginanni, J.M.; O`Neill, L.J. [USDOE Nevada Operations Office, Las Vegas, NV (United States); Hammermeister, D.P.; Blout, D.O.; Dozier, B.L.; Sully, M.J.; Johnejack, K.R.; Emer, D.F. [Reynolds Electrical and Engineering Co., Inc., Las Vegas, NV (United States); Tyler, S.W. [Nevada Univ., Reno, NV (United States). Desert Research Inst.

    1994-06-01

    An in-depth subsurface site characterization and monitoring program for the soil water migration pathway has been planned, implemented, and completed to satisfy data requirements for a waiver from groundwater monitoring, for an exemption from liner leachate collections systems, and for different regulatory driven performance assessments. A traditional scientific approach has been taken to focus characterization and monitoring efforts. This involved developing a conceptual model of the hydrogeologic system and defining and testing hypotheses about this model. Specific hypotheses tested included: that the system was hydrologically heterogenous and anisotropic, and that recharge was very low or negligible. Mineralogical, physical, and hydrologic data collected to test hypotheses has shown the hydrologic system to be remarkably homogenous and isotropic rather than heterogenous and anisotropic. Both hydrodynamic and environmental tracer approaches for estimating recharge have led to the conclusion that recharge from the Area 5 RWMS is not occurring in the upper region of the vadose zone, and that recharge at depth is extremely small or negligible. This demonstration of ``no migration of hazardous constituents to the water table satisfies a key requirement for both the groundwater monitoring waiver and the exemption from liner leachate collection systems. Data obtained from testing hypotheses concerning the soil water migration pathway have been used to refine the conceptual model of the hydrogeologic system of the site. These data suggest that the soil gas and atmospheric air pathways may be more important for transporting contaminants to the accessible environment than the soil water pathway. New hypotheses have been developed about these pathways, and characterization and monitoring activities designed to collect data to test these hypotheses.

  12. Waste site characterization and remediation: Problems in developing countries

    Energy Technology Data Exchange (ETDEWEB)

    Kalavapudi, M. [ENVIROSYS, Gaithersburg, MD (United States); Iyengar, V. [Biomineral Sciences International Inc., Bethesda, MD (United States)

    1996-12-31

    Increased industrial activities in developing countries have degraded the environment, and the impact on the environment is further magnified because of an ever-increasing population, the prime receptors. Independent of the geographical location, it is possible to adopt effective strategies to solve environmental problems. In the United States, waste characterization and remediation practices are commonly used for quantifying toxic contaminants in air, water, and soil. Previously, such procedures were extraneous, ineffective, and cost-intensive. Reconciliation between the government and stakeholders, reinforced by valid data analysis and environmental exposure assessments, has allowed the {open_quotes}Brownfields{close_quotes} to be a successful approach. Certified reference materials and standard reference materials from the National Institute of Standards (NIST) are indispensable tools for solving environmental problems and help to validate data quality and the demands of legal metrology. Certified reference materials are commonly available, essential tools for developing good quality secondary and in-house reference materials that also enhance analytical quality. This paper cites examples of environmental conditions in developing countries, i.e., industrial pollution problems in India, polluted beaches in Brazil, and deteriorating air quality in countries, such as Korea, China, and Japan. The paper also highlights practical and effective approaches for remediating these problems. 23 refs., 7 figs., 1 tab.

  13. A multidisciplinary fractured rock characterization study at Raymond field site, Raymond, CA

    Science.gov (United States)

    Karasaki, K.; Freifeld, B.; Cohen, A.; Grossenbacher, K.; Cook, P.; Vasco, D.

    2000-09-01

    A dedicated field site was developed and a suite of experiments were conducted in the Sierra Nevada foothills, near the town of Raymond, CA to develop and test a multi-disciplinary approach to the characterization of groundwater flow and transport in fractured rocks. A wealth of geologic, hydrologic and geophysical data was collected at the site using a variety of unique tools. A cluster of nine approximately 90 m deep boreholes were drilled at the site in a V-shaped pattern with an angle of 60°. The boreholes are spaced 7.5, 15, 30 and 60 m from the central borehole. Various geophysical and hydrologic tests were conducted in and between these boreholes. Integration of cross-hole radar and seismic tomography, borehole flow surveys and images from a new digital borehole scanner indicated that groundwater flow is mainly confined to a few sub-horizontal fracture zones. A unique suite of hydraulic tests were conducted, in which three to four intervals in each of the nine boreholes were isolated using pneumatic packers. Some 130 injection tests were conducted, and more than 4100 cross-hole transient pressure measurements were obtained. A computer algorithm was developed to analyze such massive interference data systematically. As a result of the analysis, an image of the fracture connections emerged, which is consistent with the geophysical data. High precision tiltmeters were effective in remotely characterizing the preferential flow path. Several radial convergent tracer tests were conducted by injecting a mixture of several conservative tracers and one sorbing tracer: deuterium, fluorescein, lithium bromide and polystyrene micro-spheres. Some differences between the breakthrough curves are observed, which may be due to possible differences among so-called "conservative" tracers. Some characterization tools were found to be more effective than others in locating flowing fractures. However, no single tool was almighty. Characterization of fractured rock is extremely

  14. [Paleoclimatology studies for Yucca Mountain site characterization]. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-03

    This report consists of two separate papers: Fernley Basin studies; and Influence of sediment supply and climate change on late Quaternary eolian accumulation patterns in the Mojave Desert. The first study involved geologic mapping of late Quaternary sediments and lacustrine features combined with precise control of elevations and descriptions of sediments for each of the major sedimentary units. The second paper documents the response of a major eolian sediment transport system in the east-central Mojave Desert: that which feeds the Kelso Dune field. Information from geomorphic, stratigraphic, and sedimentologic studies of eolian deposits and landforms is combined with luminescence dating of these deposits to develop a chronology of periods of eolian deposition. Both studies are related to site characterization studies of Yucca Mountain and the forecasting of rainfall patterns possible for the high-level radioactive waste repository lifetime.

  15. Wetlands Assessment for site characterization, Advanced Neutron Source (ANS)

    Energy Technology Data Exchange (ETDEWEB)

    Wade, M.C.; Socolof, M.L. [Oak Ridge National Lab., TN (United States). Energy Div.; Rosensteel, B.; Awl, D. [JAYCOR, Vienna, VA (United States)

    1994-10-01

    This Wetlands Assessment has been prepared in accordance with the Department of Energy`s (DOE) Code of Federal Regulations (CFR) 10 CFR 1022, Compliance with Floodplain/Wetlands Environmental Review Requirements, which established the policy and procedure for implementing Executive Order 11990, Protection of Wetlands. The proposed action is to conduct characterization activities in or near wetlands at the ANS site. The proposed action will covered under a Categorical Exclusion, therefore this assessment is being prepared as a separate document [10 CFR 1022.12(c)]. The purpose of this Wetlands Assessment is to fulfill the requirements of 10 CFR 1022.12(a) by describing the project, discussing the effects of the proposed action upon the wetlands, and considering alternatives to the proposed action.

  16. Site characterization plan: Yucca Mountain site, Nevada research and development area, Nevada: Consultation draft, Nuclear Waste Policy Act: Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-01-01

    The Yucca Mountain site in Nevada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared in accordance with the requirements of the Nuclear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site; to describe the conceptual designs for the repository and the waste package and to present the plans for obtaining the geologic information necessary to demonstrate the suitability of the site for a repository, to design the repository and the waste package, to prepare an environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. Chapter 3 summarizes present knowledge of the regional and site hydrologic systems. The purpose of the information presented is to (1) describe the hydrology based on available literature and preliminary site-exploration activities that have been or are being performed and (2) provide information to be used to develop the hydrologic aspects of the planned site characterization program. Chapter 4 contains geochemical information about the Yucca Mountain site. The chapter references plan for continued collection of geochemical data as a part of the site characterization program. Chapter 4 describes and evaluates data on the existing climate and site meterology, and outlines the suggested procedures to be used in developing and validating methods to predict future climatic variation. 534 refs., 100 figs., 72 tabs.

  17. PEP-SiteFinder: a tool for the blind identification of peptide binding sites on protein surfaces.

    Science.gov (United States)

    Saladin, Adrien; Rey, Julien; Thévenet, Pierre; Zacharias, Martin; Moroy, Gautier; Tufféry, Pierre

    2014-07-01

    Peptide-protein interactions are important to many processes of life, particularly for signal transmission or regulatory mechanisms. When no information is known about the interaction between a protein and a peptide, it is of interest to propose candidate sites of interaction at the protein surface, to assist the design of biological experiments to probe the interaction, or to serve as a starting point for more focused in silico approaches. PEP-SiteFinder is a tool that will, given the structure of a protein and the sequence of a peptide, identify protein residues predicted to be at peptide-protein interface. PEP-SiteFinder relies on the 3D de novo generation of peptide conformations given its sequence. These conformations then undergo a fast blind rigid docking on the complete protein surface, and we have found, as the result of a benchmark over 41 complexes, that the best poses overlap to some extent the experimental patch of interaction for close to 90% complexes. In addition, PEP-SiteFinder also returns a propensity index we have found informative about the confidence of the prediction. The PEP-SiteFinder web server is available at http://bioserv.rpbs.univ-paris-diderot.fr/PEP-SiteFinder. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  18. Atmospheric emission characterization of Marcellus shale natural gas development sites.

    Science.gov (United States)

    Goetz, J Douglas; Floerchinger, Cody; Fortner, Edward C; Wormhoudt, Joda; Massoli, Paola; Knighton, W Berk; Herndon, Scott C; Kolb, Charles E; Knipping, Eladio; Shaw, Stephanie L; DeCarlo, Peter F

    2015-06-02

    Limited direct measurements of criteria pollutants emissions and precursors, as well as natural gas constituents, from Marcellus shale gas development activities contribute to uncertainty about their atmospheric impact. Real-time measurements were made with the Aerodyne Research Inc. Mobile Laboratory to characterize emission rates of atmospheric pollutants. Sites investigated include production well pads, a well pad with a drill rig, a well completion, and compressor stations. Tracer release ratio methods were used to estimate emission rates. A first-order correction factor was developed to account for errors introduced by fenceline tracer release. In contrast to observations from other shale plays, elevated volatile organic compounds, other than CH4 and C2H6, were generally not observed at the investigated sites. Elevated submicrometer particle mass concentrations were also generally not observed. Emission rates from compressor stations ranged from 0.006 to 0.162 tons per day (tpd) for NOx, 0.029 to 0.426 tpd for CO, and 67.9 to 371 tpd for CO2. CH4 and C2H6 emission rates from compressor stations ranged from 0.411 to 4.936 tpd and 0.023 to 0.062 tpd, respectively. Although limited in sample size, this study provides emission rate estimates for some processes in a newly developed natural gas resource and contributes valuable comparisons to other shale gas studies.

  19. Patient-oriented interactive E-health tools on U.S. hospital Web sites.

    Science.gov (United States)

    Huang, Edgar; Chang, Chiu-Chi Angela

    2012-01-01

    The purpose of this study is to provide evidence for strategic planning regarding e-health development in U.S. hospitals. A content analysis of a representative sample of the U.S. hospital Web sites has revealed how U.S. hospitals have taken advantage of the 21 patient-oriented interactive tools identified in this study. Significant gaps between various types of hospitals have also been found. It is concluded that although the majority of the U.S. hospitals have adopted traditional functional tools, they need to make significant inroad in implementing the core e-business tools to serve their patients/users, making their Web sites more efficient marketing tools.

  20. Site characterization plan: Yucca Mountain site, Nevada research and development area, Nevada: Consultation draft, Nuclear Waste Policy Act: Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-01-01

    The Yucca Mountain site in Nevada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared in acordance with the requirements of the Nuclear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site;to describe the conceptual designs for the repository and the waste package and to present the plans for obtaining the geologic information necessary to demonstrate the suitability of the site for a repository, to design the repository and the waste package, to prepare an environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. This introduction begins with a brief section on the process for siting and eveloping a repository, followed by a discussion of the pertinent legislation and regulations. A description of site characterization is presented next;it describes the facilities to be constructed for the site characterization program and explains the principal activities to be conducted during the program. Finally, the purpose, content, organizing prinicples, and organization of this site characterization plan are outlined, and compliance with applicable regulations is discussed. 880 refs., 130 figs., 25 tabs.

  1. Site characterization plan: Yucca Mountain site, Nevada research and development area, Nevada: Consultation draft, Nuclear Waste Policy Act: Volume 6

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-01-01

    The Yucca Mountain site in Nevada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared in accordance with the requirements of the Nuclear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site;to describe the conceptual designs for the repository and the waste package;and to present the plans for obtaining the geologic information necessary to demonstrate the suitability of the site for repository, to design the repository and the waste package, to prepare an environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. This introduction begins with a brief section on the process for siting and developing a repository, followed by a discussion of the pertinent legislation and regulations. A description of site characterization is presented next;it describes the facilities to be constructed for the site characterization program and explains the principal activities to be conducted during the program. Finally, the purpose, content, organizing principles, and organization of this site characterization plan are outlined, and compliance with applicable regulations is discussed.

  2. Site characterization plan: Yucca Mountain site, Nevada research and development area, Nevada: Consultation draft, Nuclear Waste Policy Act

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-01-01

    The Yucca Mountain site in Nevada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended by the Secretary of Energy and approved by the President for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared by the US Department of Energy (DOE) in accordance with the requirements of the Nulcear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site;to describe the conceptual designs for the repository and the waste package;and to present the plans for obtaining the geologic information necessary to demonstrate the suitability of the site for a repository, to design the repository and the waste package, to prepare an environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. This introduction begins with a brief section on the process for siting and developing a repository, followed by a discussion of the pertinent legislation and regulations. A description of site characterization is presented next;it describes the facilities to be constructed for the site characterization program and explains the principal activities to be conducted during the program. Finally, the purpose, content, organizing principles, and organization of the site characterization plan are oulined, and compliance with applicable regulations is discussed.

  3. Site characterization plan: Yucca Mountain site, Nevada research and development area, Nevada: Consultation draft, Nuclear Waste Policy Act: Volume 4

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-01-01

    The Yucca Mountain site in Nevada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended and approved by the President for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared in accordance with the requirements of the Nuclear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site; to describe the conceptual designs for the repository and the waste package; and to present the plans for obtaining the geologic information necessary to demonstate the suitability of the site for a repository, to desin the repository and the waste package, to prepare an environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. This introduction begins with a brief section on the process for siting and developing a repository, followed by a discussion of the pertinent legislation and regulations. A description of site characterization is presented next; it describes the facilities to be constructed for the site characterization program and explains the principal activities to be conducted during the program. Finally, the purpose, content, organizing principles, and organization of this site characterization plan are outlined, and compliance with applicable regulations is discussed.

  4. Site characterization plan: Yucca Mountain site, Nevada research and development area, Nevada: Consultation draft, Nuclear Waste Policy Act: Volume 7

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-01-01

    The Yucca Mountain site in Neavada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended and approved for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared in accordance with the requirements of the Nuclear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site;to describe the conceptual designs for the repository and the waste package;and to present the plans for obtaining hte geologic information necessary to demonstrate the suitability of the site for a repository, to design the repository and the waste package, to prepare and environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. This introduction begins with a brief section on the process for siting and developing a repository, followed by a discussion of the pertinent legislation and regulations. A description of site characterization is presented next;it describes the facilities to be constructed for the site characterization program and explains the principal activities to be conducted during the program. Finally, the purpose, content, organizing principles, and organization of this site characterization plan are outlined, and compliance with applicable regulations is discussed.

  5. Site characterization and site response in Port-au-Prince, Haiti

    Science.gov (United States)

    Hough, Susan E.; Yong, Alan K.; Altidor, Jean Robert; Anglade, Dieuseul; Given, Douglas D.; Mildor, Saint-Louis

    2011-01-01

    Waveform analysis of aftershocks of the Mw7.0 Haiti earthquake of 12 January 2010 reveals amplification of ground motions at sites within the Cul de Sac valley in which Port-au-Prince is situated. Relative to ground motions recorded at a hard-rock reference site, peak acceleration values are amplified by a factor of approximately 1.8 at sites on low-lying Mio-Pliocene deposits in central Port-au-Prince and by a factor of approximately 2.5–3 on a steep foothill ridge in the southern Port-au-Prince metropolitan region. The observed amplitude, predominant periods, variability, and polarization of amplification are consistent with predicted topographic amplification by a steep, narrow ridge. A swath of unusually high damage in this region corresponds with the extent of the ridge where high weak-motion amplifications are observed. We use ASTER (Advanced Spaceborne Thermal Emission and Reflection Radiometer) imagery to map local geomorphology, including characterization of both near-surface and of small-scale topographic structures that correspond to zones of inferred amplification.

  6. Polarimetry: a primary tool for the physical characterization of asteroids

    Science.gov (United States)

    Cellino, A.; Bagnulo, S.

    2015-10-01

    Asteroid polarimetry has taken profit in recent years of a renewed interest triggered by exciting results from observing campaigns and theoretical studies. One of the most important applications of polarimetry to asteroid studies is the derivation of the geometric albedo and of the typical sizes of the particles forming the regolith layer covering the surface. Moreover, the serendipitous discovery of a new class of asteroids displaying unusual polarimetric properties, the so-called "Barbarians", has been followed by increasing evidence that these objects can be extremely primitive and may be interpreted as remnants of the very first generation of solid bodies accreted in the inner Solar System. In addition, some results of asteroid polarimetry are going to be interpreted, for the first time, in terms of some "ground truth" evidence, made possible by in situ observations of the surface of the asteroid (4) Vesta by the Dawn space probe. Finally, some preliminary evidence suggests that spectro-polarimetry is going to become a major tool for the physical characterization of the small bodies of the solar system.

  7. BioReD: Biomarkers and Tools for Reductive Dechlorination Site Assessment, Monitoring and Management

    Science.gov (United States)

    2013-11-01

    Utility of Microarrays as Site Assesment and Bioremediation Monitoring Tools 60 Blue Native Polyacrylamide Gel Electrophoresis (BN-PAGE) 61... computational approaches, these bioinformatics tools will continue to improve rapidly, thereby reducing analysis time and costs. From a practical...metabolism of Dehalococcoides with a constraint-based model. PLoS Comput Biol 6:pii: e1000887. 72. Johnson, D. R., P. K. Lee, V. F. Holmes, and L. Alvarez

  8. Advanced airborne geophysics for site and watershed characterization and remediation

    Energy Technology Data Exchange (ETDEWEB)

    Brown, B.; Hodges, G. [Fugro Airborne Surveys, Mississauga, ON (Canada)

    2007-04-01

    Airborne geophysics systems now have the ability to make accurately map the conductivity of the earth's subsurface. This article provided details of various site characterization surveys conducted using helicopter electromagnetic (HEM) surveys. Recent improvements in computer software, the use of global positioning systems (GPS), lasers, and fiber optics have increased the ability of HEM systems to accurately map ground conditions. Airborne electromagnetic survey techniques were used to characterize the geological features and lithology of the Sulphur Bank Mercury Mine (SBMM) on the eastern shore of Clear Lake in California. Natural conduits for the movement of groundwater were identified. Data showed that acidic water and mercury from the mine were contaminating the lake. The data showed good agreement with results obtained from previous conventional geologic and hydrologic investigations. HEM surveys were also used to characterize conductive mine pools and groundwater plumes at areas in the eastern United States that contained abandoned surface and underground coal mines. HEM was used to delineate source areas and flow paths for acidic, metal-containing groundwater, and data obtained from the surveys were used to plan mitigation activities. The survey identified 11 mine pools, as well as flooded workings that had previously not been mapped. HEM surveys were also used to map water-bearing fractures in areas of crystalline bedrock in drought-ridden regions in Brazil. Information from the surveys was used to locate drill targets for water wells. A test survey was used to identify wellheads leaking methane in a privately-owned gas field in Wyoming. Five methane leakage plumes were detected as a result of the survey. HEM geophysical surveys have also been used to map conductivity variations due to changes in water salinity at the Biscayne aquifer in the Florida everglades. It was concluded that airborne and HEM surveys provide significant cost savings when

  9. Characterization of polluted sites. Assessment of pollutant behaviour and transfer in mediums; Caracterisation des sites pollues. L`evaluation du comportement et du transfert des polluants dans les milieux

    Energy Technology Data Exchange (ETDEWEB)

    Goubier, R. [Agence de l`Environnement et de la Maitrise de l`Energie, 75 - Paris (France); Chassagnac, T. [CSD Azur (France); Schlegel, T. [ATE, (France); Coste, B. [ANTEA, (France)

    1996-12-31

    After a presentation of methods and tools for the basic and extensive characterization of polluted sites and the study of evolution and transfer of current organic pollutants in the ground, the example of the rehabilitation of an old Rhone-Poulenc site (at Chauny, France) polluted with metals and arsenic, is described: soil and aquifer diagnosis, risk analysis and determination of migration schemes

  10. A tool for calculating binding-site residues on proteins from PDB structures

    Directory of Open Access Journals (Sweden)

    Hu Jing

    2009-08-01

    Full Text Available Abstract Background In the research on protein functional sites, researchers often need to identify binding-site residues on a protein. A commonly used strategy is to find a complex structure from the Protein Data Bank (PDB that consists of the protein of interest and its interacting partner(s and calculate binding-site residues based on the complex structure. However, since a protein may participate in multiple interactions, the binding-site residues calculated based on one complex structure usually do not reveal all binding sites on a protein. Thus, this requires researchers to find all PDB complexes that contain the protein of interest and combine the binding-site information gleaned from them. This process is very time-consuming. Especially, combing binding-site information obtained from different PDB structures requires tedious work to align protein sequences. The process becomes overwhelmingly difficult when researchers have a large set of proteins to analyze, which is usually the case in practice. Results In this study, we have developed a tool for calculating binding-site residues on proteins, TCBRP http://yanbioinformatics.cs.usu.edu:8080/ppbindingsubmit. For an input protein, TCBRP can quickly find all binding-site residues on the protein by automatically combining the information obtained from all PDB structures that consist of the protein of interest. Additionally, TCBRP presents the binding-site residues in different categories according to the interaction type. TCBRP also allows researchers to set the definition of binding-site residues. Conclusion The developed tool is very useful for the research on protein binding site analysis and prediction.

  11. A tool for calculating binding-site residues on proteins from PDB structures.

    Science.gov (United States)

    Hu, Jing; Yan, Changhui

    2009-08-03

    In the research on protein functional sites, researchers often need to identify binding-site residues on a protein. A commonly used strategy is to find a complex structure from the Protein Data Bank (PDB) that consists of the protein of interest and its interacting partner(s) and calculate binding-site residues based on the complex structure. However, since a protein may participate in multiple interactions, the binding-site residues calculated based on one complex structure usually do not reveal all binding sites on a protein. Thus, this requires researchers to find all PDB complexes that contain the protein of interest and combine the binding-site information gleaned from them. This process is very time-consuming. Especially, combing binding-site information obtained from different PDB structures requires tedious work to align protein sequences. The process becomes overwhelmingly difficult when researchers have a large set of proteins to analyze, which is usually the case in practice. In this study, we have developed a tool for calculating binding-site residues on proteins, TCBRP http://yanbioinformatics.cs.usu.edu:8080/ppbindingsubmit. For an input protein, TCBRP can quickly find all binding-site residues on the protein by automatically combining the information obtained from all PDB structures that consist of the protein of interest. Additionally, TCBRP presents the binding-site residues in different categories according to the interaction type. TCBRP also allows researchers to set the definition of binding-site residues. The developed tool is very useful for the research on protein binding site analysis and prediction.

  12. Computer-based tools for decision support at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Doctor, P.G.; Mahaffey, J.A.; Cowley, P.J.; Freshley, M.D.; Hassig, N.L.; Brothers, J.W.; Glantz, C.S.; Strachan, D.M.

    1992-11-01

    To help integrate activities in the environmental restoration and waste management mission of the Hanford Site, the Hanford Integrated Planning Project (HIPP) was established and funded by the US Department of Energy. The project is divided into three key program elements, the first focusing on an explicit, defensible and comprehensive method for evaluating technical options. Based on the premise that computer technology can be used to support the decision-making process and facilitate integration among programs and activities, the Decision Support Tools Task was charged with assessing the status of computer technology for those purposes at the Site. The task addressed two types of tools: tools need to provide technical information and management support tools. Technical tools include performance and risk assessment models, information management systems, data and the computer infrastructure to supports models, data, and information management systems. Management decision support tools are used to synthesize information at a high' level to assist with making decisions. The major conclusions resulting from the assessment are that there is much technical information available, but it is not reaching the decision-makers in a form to be used. Many existing tools provide components that are needed to integrate site activities; however, some components are missing and, more importantly, the glue'' or connections to tie the components together to answer decision-makers questions is largely absent. Top priority should be given to decision support tools that support activities given in the TPA. Other decision tools are needed to facilitate and support the environmental restoration and waste management mission.

  13. Computer-based tools for decision support at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Doctor, P.G.; Mahaffey, J.A.; Cowley, P.J.; Freshley, M.D.; Hassig, N.L.; Brothers, J.W.; Glantz, C.S.; Strachan, D.M.

    1992-11-01

    To help integrate activities in the environmental restoration and waste management mission of the Hanford Site, the Hanford Integrated Planning Project (HIPP) was established and funded by the US Department of Energy. The project is divided into three key program elements, the first focusing on an explicit, defensible and comprehensive method for evaluating technical options. Based on the premise that computer technology can be used to support the decision-making process and facilitate integration among programs and activities, the Decision Support Tools Task was charged with assessing the status of computer technology for those purposes at the Site. The task addressed two types of tools: tools need to provide technical information and management support tools. Technical tools include performance and risk assessment models, information management systems, data and the computer infrastructure to supports models, data, and information management systems. Management decision support tools are used to synthesize information at a high` level to assist with making decisions. The major conclusions resulting from the assessment are that there is much technical information available, but it is not reaching the decision-makers in a form to be used. Many existing tools provide components that are needed to integrate site activities; however, some components are missing and, more importantly, the ``glue`` or connections to tie the components together to answer decision-makers questions is largely absent. Top priority should be given to decision support tools that support activities given in the TPA. Other decision tools are needed to facilitate and support the environmental restoration and waste management mission.

  14. Application of new technologies for characterization of Hanford Site high-level waste

    Energy Technology Data Exchange (ETDEWEB)

    Winters, W.I.

    1998-02-03

    To support remediation of Hanford Site high-level radioactive waste tanks, new chemical and physical measurement technologies must be developed and deployed. This is a major task of the Chemistry Analysis Technology Support (CATS) group of the Hanford Corporation. New measurement methods are required for efficient and economical resolution of tank waste safety, waste retrieval, and disposal issues. These development and deployment activities are performed in cooperation with Waste Management Federal Services of Hanford, Inc. This paper provides an overview of current analytical technologies in progress. The high-level waste at the Hanford Site is chemically complex because of the numerous processes used in past nuclear fuel reprocessing there, and a variety of technologies is required for effective characterization. Programmatic and laboratory operational needs drive the selection of new technologies for characterizing Hanford Site high-level waste, and these technologies are developed for deployment in laboratories, hot cells or in the field. New physical methods, such as the propagating reactive systems screening tool (PRSST) to measure the potential for self-propagating reactions in stored wastes, are being implemented. Technology for sampling and measuring gases trapped within the waste matrix is being used to evaluate flammability hazards associated with gas releases from stored wastes. Application of new inductively coupled plasma and laser ablation mass spectrometry systems at the Hanford Site`s 222-S Laboratory will be described. A Raman spectroscopy probe mounted in a cone penetrometer to measure oxyanions in wastes or soils will be described. The Hanford Site has used large volumes of organic complexants and acids in processing waste, and capillary zone electrophoresis (CZE) methods have been developed for determining several of the major organic components in complex waste tank matrices. The principles involved, system installation, and results from

  15. An ArcGIS decision support tool for artificial reefs site selection (ArcGIS ARSS)

    Science.gov (United States)

    Stylianou, Stavros; Zodiatis, George

    2017-04-01

    Although the use and benefits of artificial reefs, both socio-economic and environmental, have been recognized with research and national development programmes worldwide their development is rarely subjected to a rigorous site selection process and the majority of the projects use the traditional (non-GIS) approach, based on trial and error mode. Recent studies have shown that the use of Geographic Information Systems, unlike to traditional methods, for the identification of suitable areas for artificial reefs siting seems to offer a number of distinct advantages minimizing possible errors, time and cost. A decision support tool (DSS) has been developed based on the existing knowledge, the multi-criteria decision analysis techniques and the GIS approach used in previous studies in order to help the stakeholders to identify the optimal locations for artificial reefs deployment on the basis of the physical, biological, oceanographic and socio-economic features of the sites. The tool provides to the users the ability to produce a final report with the results and suitability maps. The ArcGIS ARSS support tool runs within the existing ArcMap 10.2.x environment and for the development the VB .NET high level programming language has been used along with ArcObjects 10.2.x. Two local-scale case studies were conducted in order to test the application of the tool focusing on artificial reef siting. The results obtained from the case studies have shown that the tool can be successfully integrated within the site selection process in order to select objectively the optimal site for artificial reefs deployment.

  16. Critical review of decision support tools for sustainability assessment of site remediation options.

    Science.gov (United States)

    Huysegoms, Lies; Cappuyns, Valérie

    2017-07-01

    In Europe alone, there are more than 2,5 million potentially contaminated sites of which 14% are expected to require remediation. Contaminated soil and groundwater can cause damage to human health as well as to valuable ecosystems. Globally more attention has been paid to this problem of soil contamination in the past decades. For example, more than 58 000 sites have been remediated in Europe between 2006 and 2011. Together with this increase in remediation projects there has been a surge in the development of new remediation technologies and decision support tools to be able to match every site and its specific characteristics to the best possible remediation alternative. In the past years the development of decision support tools (DST) has evolved in a more sustainable direction. Several DSTs added the claim not only to denote effective or technologically and economically feasible remediation alternatives but also to point out the more or most sustainable remediation alternatives. These trends in the evaluation of site remediation options left users with a confusing clew of possibly applicable tools to assist them in decision making for contaminated site remediation. This review provides a structured overview on the extent decision support tools for contaminated site remediation, that claim to assist in choosing the most sustainable remediation alternative, actually include the different elements of sustainability proposed in our assessment framework. The review contains an in-depth analysis of thirteen tools specifically developed to assess the sustainability of site remediation alternatives. This analysis is based on six criteria derived from the definition of sustainable development of the Brundtland report. The six criteria were concretized by using the three pillars of sustainability, applied to site remediation according to the SuRF-UK framework, two criteria derived from Life Cycle Assessment and Cost-Benefit Analysis, and an 'User friendly' criterion

  17. AC susceptibility as a characterization tool for coated conductor tapes

    Science.gov (United States)

    Gömöry, F.; Vojenčiak, M.; Solovyov, M.; Frolek, L.; Šouc, J.; Seiler, E.; Bauer, M.; Falter, M.

    2017-11-01

    The measurement and analysis of magnetic AC susceptibility is a useful tool in the study of superconductor (SC) materials. Exposure of a sample to a magnetic field changing in time generates loops of electrical currents that are detectable in a contactless way with the help of a suitable pick-up system. In this paper the applicability of this technique in the characterization and quality control of coated conductor (CC) tapes is evaluated. First we recollect the essential results of the analytical theory derived for thin SC strips and their extrapolation to strips with finite thickness. From the analytical expressions one can see how the properties of CC tape that are important for application in electric power devices, namely its critical current and AC loss, can be deduced from AC susceptibility data in straightforward way. The main focus of our study is to investigate the influence that various cases of non-uniformities in SC layer exhibit on the magnetic properties examined in an AC regime. Numerical computations were used to explore the consequences of lateral variation in the critical current density. Predictions derived for some model cases were compared with experimental findings. A dedicated experiment was also carried out to demonstrate that a transverse scratch that would be detrimental for DC transport could sneak unobserved through the AC magnetic experiment on a long sample. Our study shows that the analysis of both parts of the complex magnetic susceptibility in place of a mere AC loss determination in a common AC magnetization experiment is worth the additional effort.

  18. Development of a Tool for Siting Low Impact Development in Urban Watersheds

    Science.gov (United States)

    Martin-Mikle, C.; de Beurs, K.; Julian, J.

    2013-12-01

    Low impact development (LID) -- a comprehensive land use planning and design approach with the goal of mitigating development impacts on hydrologic/nutrient cycles and ecosystems -- is increasingly being touted as an effective approach to lessen overland runoff and pollutant loadings. Examples of LIDs include riparian buffers, grassed swales, detention/retention ponds, rain gardens, green roofs and rain barrels. Broad-scale decision support tools for siting LIDs have been developed for agricultural watersheds, but are rare for urban watersheds, largely due to greater land use complexity and lack of necessary high-resolution geospatial data. Here, we develop a framework to assist city planners and water quality managers in siting LIDs in urban watersheds. One key component of this research is a framework accessible to those interested in using it. Hence, development of the framework has centered around 1) determining optimal data requirements for siting LID in an urban watershed and 2) developing a tool compatible with both open-source and commercial GIS software. We employ a wide variety of landscape metrics to evaluate the tool. A case study of the Lake Thunderbird Watershed, an urbanized watershed southeast of Oklahoma City, illustrates the effectiveness of a tool that is capable of siting LID in an urban watershed.

  19. SafetyAnalyst : software tools for safety management of specific highway sites

    Science.gov (United States)

    2010-07-01

    SafetyAnalyst provides a set of software tools for use by state and local highway agencies for highway safety management. SafetyAnalyst can be used by highway agencies to improve their programming of site-specific highway safety improvements. SafetyA...

  20. Comprehensive characterization of atmospheric organic carbon at a forested site

    Science.gov (United States)

    Hunter, James F.; Day, Douglas A.; Palm, Brett B.; Yatavelli, Reddy L. N.; Chan, Arthur W. H.; Kaser, Lisa; Cappellin, Luca; Hayes, Patrick L.; Cross, Eben S.; Carrasquillo, Anthony J.; Campuzano-Jost, Pedro; Stark, Harald; Zhao, Yunliang; Hohaus, Thorsten; Smith, James N.; Hansel, Armin; Karl, Thomas; Goldstein, Allen H.; Guenther, Alex; Worsnop, Douglas R.; Thornton, Joel A.; Heald, Colette L.; Jimenez, Jose L.; Kroll, Jesse H.

    2017-10-01

    Atmospheric organic compounds are central to key chemical processes that influence air quality, ecological health, and climate. However, longstanding difficulties in predicting important quantities such as organic aerosol formation and oxidant lifetimes indicate that our understanding of atmospheric organic chemistry is fundamentally incomplete, probably due in part to the presence of organic species that are unmeasured using standard analytical techniques. Here we present measurements of a wide range of atmospheric organic compounds--including previously unmeasured species--taken concurrently at a single site (a ponderosa pine forest during summertime) by five state-of-the-art mass spectrometric instruments. The combined data set provides a comprehensive characterization of atmospheric organic carbon, covering a wide range in chemical properties (volatility, oxidation state, and molecular size), and exhibiting no obvious measurement gaps. This enables the first construction of a measurement-based local organic budget, highlighting the high emission, deposition, and oxidation fluxes in this environment. Moreover, previously unmeasured species, including semivolatile and intermediate-volatility organic species (S/IVOCs), account for one-third of the total organic carbon, and (within error) provide closure on both OH reactivity and potential secondary organic aerosol formation.

  1. PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites.

    Directory of Open Access Journals (Sweden)

    Jiangning Song

    Full Text Available The ability to catalytically cleave protein substrates after synthesis is fundamental for all forms of life. Accordingly, site-specific proteolysis is one of the most important post-translational modifications. The key to understanding the physiological role of a protease is to identify its natural substrate(s. Knowledge of the substrate specificity of a protease can dramatically improve our ability to predict its target protein substrates, but this information must be utilized in an effective manner in order to efficiently identify protein substrates by in silico approaches. To address this problem, we present PROSPER, an integrated feature-based server for in silico identification of protease substrates and their cleavage sites for twenty-four different proteases. PROSPER utilizes established specificity information for these proteases (derived from the MEROPS database with a machine learning approach to predict protease cleavage sites by using different, but complementary sequence and structure characteristics. Features used by PROSPER include local amino acid sequence profile, predicted secondary structure, solvent accessibility and predicted native disorder. Thus, for proteases with known amino acid specificity, PROSPER provides a convenient, pre-prepared tool for use in identifying protein substrates for the enzymes. Systematic prediction analysis for the twenty-four proteases thus far included in the database revealed that the features we have included in the tool strongly improve performance in terms of cleavage site prediction, as evidenced by their contribution to performance improvement in terms of identifying known cleavage sites in substrates for these enzymes. In comparison with two state-of-the-art prediction tools, PoPS and SitePrediction, PROSPER achieves greater accuracy and coverage. To our knowledge, PROSPER is the first comprehensive server capable of predicting cleavage sites of multiple proteases within a single substrate

  2. Characterization and identification of ubiquitin conjugation sites with E3 ligase recognition specificities.

    Science.gov (United States)

    Nguyen, Van-Nui; Huang, Kai-Yao; Huang, Chien-Hsun; Chang, Tzu-Hao; Bretaña, Neil; Lai, K; Weng, Julia; Lee, Tzong-Yi

    2015-01-01

    In eukaryotes, ubiquitin-conjugation is an important mechanism underlying proteasome-mediated degradation of proteins, and as such, plays an essential role in the regulation of many cellular processes. In the ubiquitin-proteasome pathway, E3 ligases play important roles by recognizing a specific protein substrate and catalyzing the attachment of ubiquitin to a lysine (K) residue. As more and more experimental data on ubiquitin conjugation sites become available, it becomes possible to develop prediction models that can be scaled to big data. However, no development that focuses on the investigation of ubiquitinated substrate specificities has existed. Herein, we present an approach that exploits an iteratively statistical method to identify ubiquitin conjugation sites with substrate site specificities. In this investigation, totally 6259 experimentally validated ubiquitinated proteins were obtained from dbPTM. After having filtered out homologous fragments with 40% sequence identity, the training data set contained 2658 ubiquitination sites (positive data) and 5532 non-ubiquitinated sites (negative data). Due to the difficulty in characterizing the substrate site specificities of E3 ligases by conventional sequence logo analysis, a recursively statistical method has been applied to obtain significant conserved motifs. The profile hidden Markov model (profile HMM) was adopted to construct the predictive models learned from the identified substrate motifs. A five-fold cross validation was then used to evaluate the predictive model, achieving sensitivity, specificity, and accuracy of 73.07%, 65.46%, and 67.93%, respectively. Additionally, an independent testing set, completely blind to the training data of the predictive model, was used to demonstrate that the proposed method could provide a promising accuracy (76.13%) and outperform other ubiquitination site prediction tool. A case study demonstrated the effectiveness of the characterized substrate motifs for

  3. Characterizing EMG data using machine-learning tools.

    Science.gov (United States)

    Yousefi, Jamileh; Hamilton-Wright, Andrew

    2014-08-01

    Effective electromyographic (EMG) signal characterization is critical in the diagnosis of neuromuscular disorders. Machine-learning based pattern classification algorithms are commonly used to produce such characterizations. Several classifiers have been investigated to develop accurate and computationally efficient strategies for EMG signal characterization. This paper provides a critical review of some of the classification methodologies used in EMG characterization, and presents the state-of-the-art accomplishments in this field, emphasizing neuromuscular pathology. The techniques studied are grouped by their methodology, and a summary of the salient findings associated with each method is presented. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. A potential Italian CCS site: site characterization and monitoring of Sulcis Basin (Sardinia).

    Science.gov (United States)

    Chiara Tartarello, Maria; Bigi, Sabina; Beaubien, Stanley Eugene; De Angelis, Davide; Graziani, Stefano; Lombardi, Salvatore; Sacco, Pietro; Ruggiero, Livio

    2017-04-01

    The Sulcis Basin is an area situated in SW Sardinia (Italy) and is a potential site for the implementation of CCS in Italy. In fact, in the last years many studies were conducted to characterize the area and to define the baseline. The "Miliolitico" has been identified as the potential reservoir and is composed by fractured carbonate, while the "Produttivo Fm.", a sequence of clay, coal and marl, is the caprock. Above the "Produttivo Fm." there is a thick volcanic sequence (more than 800 m) that could be considered also a secondary caprock. In the area of Matzaccara, the "Miliolitico" is below an alluvial plain and it is estimates that could reach a depth of more than 800 m. To characterize the reservoir-caprock system there were conducted an extensive structural-geological survey, and more in detail a fracture analysis on all the Formation at the outcrop. With regard to the faults, it has been examined their architecture, and in particular the conduit-barrier behaviors. Moreover, to evaluate the theoretical capacity of the potential reservoir, we built a Discrete Fracture Model, using the fracture data collected at outcrop. So, we estimate a secondary porosity of about 3%. As regards to the definition of geochemical baseline, it has been conducted both discontinuous and continuous monitoring of CO2 and other gases. More in details, there were carried out a regional and a detailed survey, measuring the concentration and the flux of CO2. in that manner, it has been possible to identify potential migration pathways along faults and to define the position of continuous monitoring station. We developed small, low-power consuming, low-cost pCO2 "GasPro", to measure the CO2 both in soil and water. In the next months, it is planned to extend the monitoring network and to inject a little quantity of CO2 along a fault in the Matzaccara plain.

  5. Final Report for Statistical Methods and Tools for UXO Site Characterization on Final Simulated Site

    Science.gov (United States)

    2006-01-31

    91 Appendix A: Variogram Parameters.................................................................................92 Appendix B: Issues...26 13 Variograms for indicator variable using a threshold of 65 anomalies per acre (top plot) and...estimate the presence or absence of UXO at unsampled locations and to identify the uncertainty in those estimates. Under SERDP funding, Sandia worked on

  6. Collaborative Tools for e-Participation across Networks: The Comuno Networking Site for Public Governance and Services

    Directory of Open Access Journals (Sweden)

    Michael Kaschesky

    2010-04-01

    Full Text Available This paper presents collaborative tools for public participation across multiple networking sites. The tools are part of the Comuno networking site for public governance and services, which is particularly targeted at the public sector (currently in alpha testing at http://comuno.org. The Broadcast tool allows cross-posting content from Comuno to a wide variety of other networking sites, such as Facebook or Twitter. The UserFeed and TopicFeed tools build RSS feeds from content published by a specific user or under a specific topic. The LifeStream tool gathers a user’s activities across multiple networking sites in the private account section at Comuno. These tools and related aspects of the Comuno networking site are discussed and presented in the context of deliberation and opinion-forming in a Swiss bilingual city.

  7. Quantification of uncertain outcomes from site characterization: Insights from the ESF-AS

    Energy Technology Data Exchange (ETDEWEB)

    Boyle, W.J.; Parrish, D.K. [RE/SPEC, Inc., Rapid City, SD (United States); Beccue, P.C. [Applied Decision Analysis, Inc., Menlo Park, CA (United States)

    1992-01-01

    As part of the Exploratory Studies Facility Alternatives Study (ESF-AS) the uncertain outcomes from site characterization were quantified using a probabilistic tree known as ``Nature`s Tree.`` Nature`s Tree distinguished the true characteristics of the Yucca Mountain site from the perceived characteristics deduced from testing. Bayesian probabilistic calculations converted probabilities in Nature`s Tree to the probabilistic estimates required for the comparative analysis of Exploratory Studies Facility-repository options. Experts on characterization testing explicitly addressed several site characterization issues that are considered implicitly in many site characterization programs.

  8. Characterization Report for the 92-Acre Area of the Area 5 Radioactive Waste Management Site, Nevada Test Site, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Bechtel Nevada; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2006-06-01

    The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office manages two low-level Radioactive Waste Management Sites at the Nevada Test Site. The Area 5 RWMS uses engineered shallow-land burial cells to dispose of packaged waste. This report summarizes characterization and monitoring work pertinent to the 92-Acre Area in the southeast part of the Area 5 Radioactive Waste Management Sites. The decades of characterization and assessment work at the Area 5 RWMS indicate that the access controls, waste operation practices, site design, final cover design, site setting, and arid natural environment contribute to a containment system that meets regulatory requirements and performance objectives for the short- and long-term protection of the environment and public. The available characterization and Performance Assessment information is adequate to support design of the final cover and development of closure plans. No further characterization is warranted to demonstrate regulatory compliance. U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office is proceeding with the development of closure plans for the six closure units of the 92-Acre Area.

  9. Structural descriptor database: a new tool for sequence-based functional site prediction

    Directory of Open Access Journals (Sweden)

    Vasconcelos Ana

    2008-11-01

    Full Text Available Abstract Background The Structural Descriptor Database (SDDB is a web-based tool that predicts the function of proteins and functional site positions based on the structural properties of related protein families. Structural alignments and functional residues of a known protein set (defined as the training set are used to build special Hidden Markov Models (HMM called HMM descriptors. SDDB uses previously calculated and stored HMM descriptors for predicting active sites, binding residues, and protein function. The database integrates biologically relevant data filtered from several databases such as PDB, PDBSUM, CSA and SCOP. It accepts queries in fasta format and predicts functional residue positions, protein-ligand interactions, and protein function, based on the SCOP database. Results To assess the SDDB performance, we used different data sets. The Trypsion-like Serine protease data set assessed how well SDDB predicts functional sites when curated data is available. The SCOP family data set was used to analyze SDDB performance by using training data extracted from PDBSUM (binding sites and from CSA (active sites. The ATP-binding experiment was used to compare our approach with the most current method. For all evaluations, significant improvements were obtained with SDDB. Conclusion SDDB performed better when trusty training data was available. SDDB worked better in predicting active sites rather than binding sites because the former are more conserved than the latter. Nevertheless, by using our prediction method we obtained results with precision above 70%.

  10. Web-based Tool Identifies and Quantifies Potential Cost Savings Measures at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Renevitz, Marisa J.; Peschong, Jon C.; Charboneau, Briant L.; Simpson, Brett C.

    2014-01-09

    The Technical Improvement system is an approachable web-based tool that is available to Hanford DOE staff, site contractors, and general support service contractors as part of the baseline optimization effort underway at the Hanford Site. Finding and implementing technical improvements are a large part of DOE’s cost savings efforts. The Technical Improvement dashboard is a key tool for brainstorming and monitoring the progress of submitted baseline optimization and potential cost/schedule efficiencies. The dashboard is accessible to users over the Hanford Local Area Network (HLAN) and provides a highly visual and straightforward status to management on the ideas provided, alleviating the need for resource intensive weekly and monthly reviews.

  11. Hanford Site National Environmental Policy Act (NEPA) characterization. Revision 10

    Energy Technology Data Exchange (ETDEWEB)

    Neitzel, D.A. [ed.; Fosmire, C.J.; Fowler, R.A. [and others

    1998-09-01

    This document describes the US Department of Energy`s (DOE) Hanford Site environment and is numbered to correspond to the chapters where such information is presented in Hanford Site NEPA related documents. The document is intended to provide a consistent description of the Hanford Site environment for the many NEPA documents that are being prepared by contractors. The two chapters in this document (Chapters 4 and 6) are numbered this way to correspond to the chapters where such information is presented in environmental impact statements (EISs) and other Site-related NEPA or CERCLA documentation. Chapter 4.0 (Affected Environment) describes the Hanford Site environment, and includes information on climate and meteorology, geology, hydrology, ecology, cultural, archaeological and historical resources, socioeconomics, and noise. Chapter 6.0 (Statutory and Regulatory Requirements) describes applicable federal and state laws and regulations, DOE directives and permits, and environmental standards directly applicable to the NEPA documents on the Hanford Site.

  12. Seismic site-response characterization of high-velocity sites using advanced geophysical techniques: application to the NAGRA-Net

    Science.gov (United States)

    Poggi, V.; Burjanek, J.; Michel, C.; Fäh, D.

    2017-08-01

    The Swiss Seismological Service (SED) has recently finalised the installation of ten new seismological broadband stations in northern Switzerland. The project was led in cooperation with the National Cooperative for the Disposal of Radioactive Waste (Nagra) and Swissnuclear to monitor micro seismicity at potential locations of nuclear-waste repositories. To further improve the quality and usability of the seismic recordings, an extensive characterization of the sites surrounding the installation area was performed following a standardised investigation protocol. State-of-the-art geophysical techniques have been used, including advanced active and passive seismic methods. The results of all analyses converged to the definition of a set of best-representative 1-D velocity profiles for each site, which are the input for the computation of engineering soil proxies (traveltime averaged velocity and quarter-wavelength parameters) and numerical amplification models. Computed site response is then validated through comparison with empirical site amplification, which is currently available for any station connected to the Swiss seismic networks. With the goal of a high-sensitivity network, most of the NAGRA stations have been installed on stiff-soil sites of rather high seismic velocity. Seismic characterization of such sites has always been considered challenging, due to lack of relevant velocity contrast and the large wavelengths required to investigate the frequency range of engineering interest. We describe how ambient vibration techniques can successfully be applied in these particular conditions, providing practical recommendations for best practice in seismic site characterization of high-velocity sites.

  13. A risk assessment tool for contaminated sites in low-permeability fractured media

    DEFF Research Database (Denmark)

    Chambon, Julie Claire Claudia; Binning, Philip John; Jørgensen, P.R.

    2010-01-01

    A risk assessment tool for contaminated sites in low-permeability fractured media is developed, based on simple transient and steady-state analytical solutions. The tool, which explicitly takes into account the transport along fractures, covers different source geometries and can be applied...... catchment. The model simulates well the presence of pesticides in drinking water wells and predicts the contamination duration, however, the early breakthrough and long term tailing cannot be validated due to lack of long term monitoring data....... to a wide range of compounds (conservative, sorbing, degradable). The superiority of this risk assessment tool compared to an Equivalent Porous Media (EPM) model is clearly demonstrated on experimental data. The use of the model for risk assessment is illustrated for diffuse pesticide sources in a Danish...

  14. CHARACTERIZATION OF GLOVEBOX GLOVES FOR THE SAVANNAH RIVER SITE

    Energy Technology Data Exchange (ETDEWEB)

    Korinko, P.

    2013-01-24

    A task was undertaken to characterize glovebox gloves that are currently used in the facilities at Savannah River Site (SRS) as well as some experimental and advanced compound gloves that have been proposed for use. Gloves from four manufacturers were tested for permeation in hydrogen and air, thermal stability, tensile properties, puncture resistance and dynamic mechanical response. The gloves were compared to each other within the type and also to the butyl rubber glove that is widely used at the SRS. The permeation testing demonstrated that the butyl compounds from three of the vendors behaved similarly and exhibited hydrogen permeabilities of .52‐.84 x10{sup ‐7} cc H{sub 2}*cm / (cm{sup 2}*atm). The Viton glove performed at the lower edge of this bound, while the more advanced composite gloves exhibited permeabilities greater than a factor of two compared to butyl. Thermogravimetric analysis was used to determine the amount of material lost under slightly aggressive conditions. Glove losses are important since they can affect the life of glovebox stripper systems. During testing at 90, 120, and 150°C, the samples lost most of the mass in the initial 60 minutes of thermal exposure and as expected increasing the temperature increased the mass loss and shortened the time to achieve a steady state loss. The ranking from worst to best was Jung butyl‐Hypalon with 12.9 %, Piercan Hypalon with 11.4 %, and Jung butyl‐Viton with 5.2% mass loss all at approximately 140°C. The smallest mass losses were experienced by the Jung Viton and the Piercan polyurethane. Tensile properties were measured using a standard dog bone style test. The butyl rubber exhibited tensile strengths of 11‐15 MPa and elongations or 660‐843%. Gloves made from other compounds exhibited lower tensile strengths (5 MPa Viton) to much higher tensile strengths (49 MPa Urethane) with a comparable range of elongation. The puncture resistance of the gloves was measured

  15. 75 FR 11914 - Chrysler, LLC, Mount Elliott Tool and Die, Including On-Site Leased Workers From Modern...

    Science.gov (United States)

    2010-03-12

    ... Workers From Modern Professional Services, TAC Automotive, Syncreon, CSC, Resource Tech, and Caravan... workers of Chrysler, LLC, Mount Elliott Tool and Die, including on-site leased workers from Modern... Tool and Die, including on-site leased workers of Modern Professional Services, TAC Automotive...

  16. How to Characterize a Potential Site for CO2 Storage with Sparse Data Coverage – a Danish Onshore Site Case

    Directory of Open Access Journals (Sweden)

    Nielsen Carsten Møller

    2015-04-01

    Full Text Available The paper demonstrates how a potential site for CO2 storage can be evaluated up to a sufficient level of characterization for compiling a storage permit application, even if the site is only sparsely explored. The focus of the paper is on a risk driven characterization procedure. In the initial state of a site characterization process with sparse data coverage, the regional geological and stratigraphic understanding of the area of interest can help strengthen a first model construction for predictive modeling. Static and dynamic modeling in combination with a comprehensive risk assessment can guide the different elements needed to be evaluated for fulfilling a permit application. Several essential parameters must be evaluated; the storage capacity for the site must be acceptable for the project life of the operation, the trap configuration must be efficient to secure long term containment, the injectivity must be sufficient to secure a longstanding stable operation and finally a satisfactory and operational measuring strategy must be designed. The characterization procedure is demonstrated for a deep onshore aquifer in the northern part of Denmark, the Vedsted site. The site is an anticlinal structural closure in an Upper Triassic – Lower Jurassic sandstone formation at 1 800-1 900 m depth.

  17. Geographic Information System Tools for Management of US DOE Sites - 13489

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, Cliff [U.S. Department of Energy Office of Legacy Management, 99 Research Park Road, Morgantown, WV 26505 (United States); Pilz, Elaine [S.M. Stoller Corporation, 2597 Legacy Way, Grand Junction, CO 81503 (United States); Pawel, Steve [S.M. Stoller Corporation, 10995 Hamilton-Cleves Highway, Harrison, OH 45030 (United States)

    2013-07-01

    The DOE Office of Legacy Management (LM) uses a variety of GIS tools to support long-term surveillance and maintenance (LTS and M) activities at DOE closure sites. These geo-spatial applications provide access to data both for external public viewing and for internal analysis and decision making. LM uses a custom geo-spatial application called geo-spatial Environmental Mapping System (GEMS) that draws validated information from a database of 4.6 million analytical results and 232,000 water level measurements for 58 LTS and M sites. These data were collected from transferred sites over a period of 40 years. The database is used to capture and store historical environmental information such as analytical chemistry data, groundwater depths and elevations, well logs, well construction data, geo-referenced boundaries, site physical features, and sampling locations from LTS and M sites. Stakeholders, regulators, and project personnel can use this Web-based application and data to display information in several forms, such as a tabular report, a graph, and a geo-spatial display, or the data can be labeled or highlighted in a map view. Institutional controls, with their LTS and M requirements and documentation, have recently been incorporated into a prototype GEMS Web page for the Weldon Spring, Missouri, Site. LM uses multiple internal GIS viewers to help ensure the future protection of human health and the environment. For example, at the Rocky Flats, Colorado, Site, LM uses a GIS application to display real property interests on authoritative maps. Another project is used to facilitate discussions at stakeholder meetings for the Rocky Flats site's Original Landfill. The Uranium Leasing Program uses multiple interactive maps that assist in ongoing monitoring and the oversight of lease-holders' activities. (authors)

  18. Ecohealth System Dynamic Model as a Planning Tool for the Reduction of Breeding Sites

    Science.gov (United States)

    Respati, T.; Raksanagara, A.; Djuhaeni, H.; Sofyan, A.; Shandriasti, A.

    2017-03-01

    Dengue is still one of major health problem in Indonesia. Dengue transmission is influenced by dengue prevention and eradication program, community participation, housing environment and climate. The complexity of the disease coupled with limited resources necessitates different approach for prevention methods that include factors contribute to the transmission. One way to prevent the dengue transmission is by reducing the mosquito’s breeding sites. Four factors suspected to influence breeding sites are dengue prevention and eradication program, community participation, housing environment, and weather condition. In order to have an effective program in reducing the breeding site it is needed to have a model which can predict existence of the breeding sites while the four factors under study are controlled. The objective of this study is to develop an Ecohealth model using system dynamic as a planning tool for the reduction of breeding sites to prevent dengue transmission with regard to dengue prevention and eradication program, community participation, housing environment, and weather condition. The methodology is a mixed method study using sequential exploratory design. The study comprised of 3 stages: first a qualitative study to 14 respondents using in-depth interview and 6 respondents for focus group discussion. The results from the first stage was used to develop entomology and household survey questionnaires for second stage conducted in 2036 households across 12 sub districts in Bandung City. Ecohealth system dynamic model was developed using data from first and second stages. Analyses used are thematic analysis for qualitative data; spatial, generalized estimating equation (GEE) and structural equation modeling for quantitative data; also average mean error (AME) and average variance error (AVE) for dynamic system model validation. System dynamic model showed that the most effective approach to eliminate breeding places was by ensuring the availability

  19. Selecting analytical tools for characterization of polymersomes in aqueous solution

    DEFF Research Database (Denmark)

    Habel, Joachim Erich Otto; Ogbonna, Anayo; Larsen, Nanna

    2015-01-01

    , lamellarity, elastic properties, bilayer surface charge, thickness and polarity of polybutadiene-polyethylene oxide (PB-PEO) based polymersomes. The techniques used in this study are broadly divided into scattering techniques, visualization methods, physical and electromagnetical manipulation and sorting...... using freeze fracture Cryo-scanning electron microscopy (FF-Cryo-SEM) and nanoparticle tracking analysis (NTA). Small angle X-ray scattering (SAXS) provides reliable data on bilayer thickness and internal structure, Cryo-TEM on multilamellarity. Taken together, these tools are valuable...

  20. Site characterization plan: Yucca Mountain Site, Nevada Research and Development Area, Nevada: Volume 1, Part A: Chapters 1 and 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-12-01

    This site characterization plan (SCP) has been developed for the candidate repository site at Yucca Mountain in the State of Nevada. The SCP includes a description of the Yucca Mountain site (Chapters 1-5), a conceptual design for the repository (Chapter 6), a description of the packaging to be used for the waste to be emplaced in the repository (Chapter 7), and a description of the planned site characterization activities (Chapter 8). The schedules and milestones presented in Sections 8.3 and 8.5 of the SCP were developed to be consistent with the June 1988 draft Amendment to the DOE`s Mission Plan for the Civilian Radioactive Waste Management Program. The five month delay in the scheduled start of exploratory shaft construction that was announced recently is not reflected in these schedules. 750 refs., 123 figs., 42 tabs.

  1. Site Characterization Plan: Yucca Mountain Site, Nevada Research and Development Area, Nevada: Volume 3, Part A: Chapters 6 and 7

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-12-01

    This site characterization plan (SCP) has been developed for the candidate repository site at Yucca Mountain in the State of Nevada. The SCP includes a description of the Yucca Mountain site (Chapters 1-5), a conceptual design for the repository (Chapter 6), a description of the packaging to be used for the waste to be emplaced in the repository (Chapter 7), and a description of the planned site characterization activities (Chapter 8). The schedules and milestones presented in Sections 8.3 and 8.5 of the SCP were developed to be consistent with the June 1988 draft Amendment to the DOE`s Mission Plan for the Civilian Radioactive Waste Management Program. The five month delay in the scheduled start of exploratory shaft construction that was announced recently is not reflected in these schedules. 218 figs., 50 tabs.

  2. Acoustic Emission Technique, an Overview as a Characterization Tool in Materials Science

    Directory of Open Access Journals (Sweden)

    C. R. Ríos-Soberanis

    2011-12-01

    Full Text Available In order to predict the mechanical behavior of a composite during its service life, it is important to evaluate its mechanical response under different types of external stresses by studying the initiation and development of cracks and the effects induced by damage and degradation. The onset of damage is related to the structural integrity of the component and its fatigue life. For this, among other reasons, non-destructive techniques such as acoustic emission(AE have been widely used nowadays for composite materials haracterization. This method has demonstrated excellent results on detecting and identifying initiations sites, cracking propagation and fracture mechanisms of polymer matrix composite and ceramic materials. This paper focuses on commenting the importance of the acoustic emission technique as a unique tool for characterizing mechanical parameters in response to external stresses and degradation processes by reviewing previous investigations carried out by the author as participant. Acoustic emission was employed to monitor the micro-failure mechanisms in composites in relation to the stress level in real-time during the tests carried out. Some results obtained from different analysis are discussed to support the significance of using AE, technique that will be increasingly employed in the composite materials field due to its several lternatives for understanding the mechanical behavior; therefore, the objective of this manuscript is to involve the benefits andadvantages of AE in the characterization of materials.

  3. The NHS Lanarkshire Intranet site (FirstPort) and its effectiveness as a knowledge management tool.

    Science.gov (United States)

    Herbert, Paul

    2013-03-01

    The use of intranets as knowledge management tools in the NHS has been applied with varying success. This study set out to evaluate the effectiveness of the NHS Lanarkshire intranet site FirstPort as a knowledge management tool and to capture opinions on what would be required of a new FirstPort 2 site to be launched in the summer of 2012. The research was conducted in June 2011 by Paul Herbert as part of MSc in Health Informatics at the University of Sheffield, supervised by Nigel Ford. At the time of the study, Paul was working at NHS Lanarkshire and he was able to give his employers a useful set of recommendations. He moved to his present post with Healthcare Improvement Scotland in June 2012. This article is the first in the Dissertations into Practice series to investigate web-based tools for information and communication inside the NHS, but there are more in the pipeline. AM. © 2013 The authors. Health Information and Libraries Journal © 2013 Health Libraries Group.

  4. Hanford Site National Environmental Policy Act (NEPA) characterization

    Energy Technology Data Exchange (ETDEWEB)

    Cushing, C.E. (ed.)

    1988-09-01

    This document describes the Hanford Site environment (Chapter 4) and contains data in Chapter 5 and 6 which will guide users in the preparation of National Environmental Policy Act (NEPA)-related documents. Many NEPA compliance documents have been prepared and are being prepared by site contractors for the US Department of Energy, and examination of these documents reveals inconsistencies in the amount of detail presented and the method of presentation. Thus, it seemed necessary to prepare a consistent description of the Hanford environment to be used in preparing Chapter 4 of environmental impact statements and other site-related NEPA documentation. The material in Chapter 5 is a guide to the models used, including critical assumptions incorporated in these models, in previous Hanford NEPA documents. The users will have to select those models appropriate for the proposed action. Chapter 6 is essentially a definitive NEPA Chapter 6, which describes the applicable laws, regulations, and DOE and state orders. In this document, a complete description of the environment is presented in Chapter 4 without excessive tabular data. For these data, sources are provided. Most subjects are divided into a general description of the characteristics of the Hanford Site, followed by site-specific information where it is available on the 100, 200, 300, and other Areas. This division will allow a person requiring information to go immediately to those sections of particular interest. However, site-specific information on each of these separate areas is not always complete or available. In this case, the general Hanford Site description should be used. 131 refs., 19 figs., 32 tabs.

  5. Hanford Site National Environmental Policy Act (NEPA) Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Rohay, A.C.; Fosmire, C.J.; Neitzel, D.A.; Hoitink, D.J.; Harvey, D.W.; Antonio, E.J.; Wright, M.K.; Thorne, P.D.; Hendrickson, P.L.; Fowler, R.A.; Goodwin, S.M.; Poston, T.M.

    1999-09-28

    This document describes the US Department of Energy's (DOE) Hanford Site environment. It is updated each year and is intended to provide a consistent description of the Hanford Site environment for the many NEPA documents being prepared by DOE contractors. No conclusions or recommendations are provided. This year's report is the eleventh revision of the original document published in 1988 and is (until replaced by the 12th revision) the only version that is relevant for use in the preparation of Hanford NEPA; SEPA and CERCLA documents. The two chapters included in this document (Chapters 4 and 6) are numbered to correspond to the chapters where such information is presented in environmental impact statements (EISs) and other Site-related NEPA or CERCLA documentation. Chapter 4.0 (Affected Environment) describes Hanford Site climate and meteorology, geology, hydrology, ecology, cultural, archaeological and historical resources, socioeconomic; occupational safety, and noise. Sources for extensive tabular data related to these topics are provided in the chapter. Most subjects are divided into a general description of the characteristics of the Hanford Site, followed by site-specific information, where available, of the 100,200,300, and other Areas. This division allows the reader to go directly to those sections of particular interest. When specific information on each of these separate areas is not complete or available, the general Hanford Site description should be used. Chapter 6.0 (Statutory and Regulatory Requirements) is essentially a definitive NEPA Chapter 6.0, which describes applicable federal and state laws and regulations, DOE directives and permits, and environmental standards directly applicable to the NEPA documents on the Hanford Site. People preparing environmental assessments and EISs should also be cognizant of the document entitled ''Recommendations for the Preparation of Environmental Assessments and Environmental Impact

  6. Hanford Site National Environmental Policy Act (NEPA) Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Neitzel, Duane A.; Antonio, Ernest J.; Eschbach, Tara O.; Fowler, Richard A.; Goodwin, Shannon M.; Harvey, David W.; Hendrickson, Paul L.; Hoitink, Dana J.; Horton, Duane G.; Last, George V.; Poston, Ted M.; Prendergast, Ellen L.; Rohay, Alan C.; Thorne, Paul D.

    2001-09-01

    This document describes the U.S. Department of Energy's (DOE) Hanford Site environment. It is updated each year and is intended to provide a consistent description of the Hanford Site environment for the many National Environmental Policy Act (NEPA) documents being prepared by DOE contractors. No statements of significance or environmental consequences are provided. This year's report is the thirteenth revision of the original document published in 1988 and is (until replaced by the fourteenth revision) the only version that is relevant for use in the preparation of Hanford NEPA, State Environmental Policy Act (SEPA), and Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) documents. The two chapters included in this document (Chapters 4 and 6) are numbered to correspond to the chapters where such information is typically presented in environmental impact statements (Weiss) and other Hanford Site NEPA or CERCLA documentation. Chapter 4.0 (Affected Environment) describes Hanford Site climate and meteorology, geology, hydrology, ecology, cultural, archaeological, and historical resources, socioeconomics, occupational safety, and noise. Chapter 6.0 (Statutory and Regulatory Requirements) describes federal and state laws and regulations, DOE directives and permits, and presidential executive orders that are applicable to the NEPA documents prepared for Hanford Site activities.

  7. Hanford Site National Environmental Policy Act (NEPA) Characterization Report

    Energy Technology Data Exchange (ETDEWEB)

    Neitzel, Duane A.; Bunn, Amoret L.; Cannon, Sandra D.; Duncan, Joanne P.; Fowler, Richard A.; Fritz, Brad G.; Harvey, David W.; Hendrickson, Paul L.; Hoitink, Dana J.; Horton, Duane G.; Last, George V.; Poston, Ted M.; Prendergast-Kennedy, Ellen L.; Reidel, Steve P.; Rohay, Alan C.; Scott, Michael J.; Thorne, Paul D.

    2004-09-22

    This document describes the U.S. Department of Energy's (DOE) Hanford Site environment. It is updated each year and is intended to provide a consistent description of the Hanford Site environment for the many National Environmental Policy Act (NEPA) documents being prepared by DOE contractors. No statements of significance or environmental consequences are provided. This year's report is the sixteenth revision of the original document published in 1988 and is (until replaced by the seventeenth revision) the only version that is relevant for use in the preparation of Hanford NEPA, State Environmental Policy Act (SEPA), and Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) documents. The two chapters included in this document (Chapters 4 and 6) are numbered to correspond to the chapters where such information is typically presented in environmental impact statements (Weiss) and other Hanford Site NEPA or CERCLA documentation. Chapter 4.0 (Affected Environment) describes Hanford Site climate and meteorology, geology, hydrology, ecology, cultural, archaeological, and historical resources, socioeconomics, occupational safety and health, and noise. Chapter 6.0 (Statutory and Regulatory Requirements) describes federal and state laws and regulations, DOE directives and permits, and presidential executive orders that are applicable to the NEPA documents prepared for Hanford Site activities.

  8. Hanford Site National Environmental Policy Act (NEPA) Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Neitzel, Duane A.; Bunn, Amoret L.; Duncan, Joanne P.; Eschbach, Tara O.; Fowler, Richard A.; Fritz, Brad G.; Goodwin, Shannon M.; Harvey, David W.; Hendrickson, Paul L.; Hoitink, Dana J.; Horton, Duane G.; Last, George V.; Poston, Ted M.; Prendergast-Kennedy, Ellen L.; Rohay, Alan C.; Scott, Michael J.; Thorne, Paul D.

    2002-09-01

    This document describes the U.S. Department of Energy's (DOE) Hanford Site environment. It is updated each year and is intended to provide a consistent description of the Hanford Site environment for the many National Environmental Policy Act (NEPA) documents being prepared by DOE contractors. No statements of significance or environmental consequences are provided. This year's report is the thirteenth revision of the original document published in 1988 and is (until replaced by the fourteenth revision) the only version that is relevant for use in the preparation of Hanford NEPA, State Environmental Policy Act (SEPA), and Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) documents. The two chapters included in this document (Chapters 4 and 6) are numbered to correspond to the chapters where such information is typically presented in environmental impact statements (Weiss) and other Hanford Site NEPA or CERCLA documentation. Chapter 4.0 (Affected Environment) describes Hanford Site climate and meteorology, geology, hydrology, ecology, cultural, archaeological, and historical resources, socioeconomics, occupational safety, and noise. Chapter 6.0 (Statutory and Regulatory Requirements) describes federal and state laws and regulations, DOE directives and permits, and presidential executive orders that are applicable to the NEPA documents prepared for Hanford Site activities.

  9. Hanford Site National Environmental Policy Act (NEPA) Characterization, Revision 15

    Energy Technology Data Exchange (ETDEWEB)

    Neitzel, Duane A.; Bunn, Amoret L.; Burk, Kenneth W.; Cannon, Sandra D.; Duncan, Joanne P.; Fowler, Richard A.; Fritz, Brad G.; Harvey, David W.; Hendrickson, Paul L.; Horton, Duane G.; Last, George V.; Poston, Ted M.; Prendergast-Kennedy, Ellen L.; Reidel, Steve P.; Scott, Michael J.; Thorne, Paul D.; Woody, Dave M.

    2003-09-01

    This document describes the U.S. Department of Energy's (DOE) Hanford Site environment. It is updated each year and is intended to provide a consistent description of the Hanford Site environment for the many National Environmental Policy Act (NEPA) documents being prepared by DOE contractors. No statements of significance or environmental consequences are provided. This year's report is the thirteenth revision of the original document published in 1988 and is (until replaced by the fourteenth revision) the only version that is relevant for use in the preparation of Hanford NEPA, State Environmental Policy Act (SEPA), and Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) documents. The two chapters included in this document (Chapters 4 and 6) are numbered to correspond to the chapters where such information is typically presented in environmental impact statements (Weiss) and other Hanford Site NEPA or CERCLA documentation. Chapter 4.0 (Affected Environment) describes Hanford Site climate and meteorology, geology, hydrology, ecology, cultural, archaeological, and historical resources, socioeconomics, occupational safety, and noise. Chapter 6.0 (Statutory and Regulatory Requirements) describes federal and state laws and regulations, DOE directives and permits, and presidential executive orders that are applicable to the NEPA documents prepared for Hanford Site activities.

  10. Electrowetting: a versatile tool for drop manipulation, generation, and characterization.

    Science.gov (United States)

    Mugele, Frieder; Duits, Michel; van den Ende, Dirk

    2010-12-15

    Electrowetting is arguably the most flexible tool to control and vary the wettability of solid surfaces by an external control parameter. In this article we briefly discuss the physical origin of the electrowetting effect and subsequently present a number of approaches for selected novel applications. Specifically, we will discuss the use of EW as a tool to extract materials properties such as interfacial tensions and elastic properties of drops. We will describe some modifications of the EW equation that apply at finite AC voltage for low conductivity fluids when the electric field can partially penetrate into the drops. We will discuss two examples where finite conductivity effects have important consequences, namely electrowetting of topographically structured surfaces as well as the generation of drops in AC electric fields. Finally, we review recent attempts to incorporate electrowetting into conventional channel-based microfluidic devices in order to enhance the flexibility of controlling the generation of drops. Copyright © 2009 Elsevier B.V. All rights reserved.

  11. Aquifer characterization through an integrated GIS-based tool

    Science.gov (United States)

    Criollo, Rotman; Velasco, Violeta; Vázquez-Suñé, Enric; Serrano-Juan, Alejandro; Alcaraz, Mar; García-Gil, Alejandro

    2016-04-01

    Hydraulic parameters of the subsurface (transmissivity, hydraulic conductivity, storativity and specific storage) are important to achieve hydrogeological studies such as environmental impact assessments, water resources evaluations or groundwater contamination remediation, among others. There are several methods to determine aquifer parameters but pumping test is the most commonly used method to obtain them and generally leads to reliable hydraulic parameters. These parameters and other hydraulic data available for integration into the hydrogeological studies (which currently are supported by groundwater numerical models) usually has a very diverse origin and format and, therefore, a chance of bias in the interpretations. Consequently, it becomes necessary to have effective instruments that facilitate the pre-process, the visualization, the analysis and the validation (e.g. graphical analysis techniques) of this great amount of data. To achieve this in a clear and understandable manner, the GIS environment is a useful instrument. We developed a software to analyze pumping tests in a GIS platform environment to support the hydraulic parameterization of groundwater flow and transport models. This novel platform provides a package of tools for collecting, managing, analyzing, processing and interpreting data derived from pumping tests in a GIS environment. Additionally, within the GIS platform, it is possible to process the hydraulic parameters obtained from the pumping test and to create spatial distribution maps, perform geostatistical analysis and export the information to an external software platform. These tools have been applied in the metropolitan area of Barcelona (Spain) to tests out and improve their usefulness in hydrogeological analysis.

  12. Development of a Multi-Site and Multi-Device Webgis-Based Tool for Tidal Current Energy Development

    Science.gov (United States)

    Ang, M. R. C. O.; Panganiban, I. K.; Mamador, C. C.; De Luna, O. D. G.; Bausas, M. D.; Cruz, J. P.

    2016-06-01

    A multi-site, multi-device and multi-criteria decision support tool designed to support the development of tidal current energy in the Philippines was developed. Its platform is based on Geographic Information Systems (GIS) which allows for the collection, storage, processing, analyses and display of geospatial data. Combining GIS tools with open source web development applications, it becomes a webGIS-based marine spatial planning tool. To date, the webGIS-based tool displays output maps and graphs of power and energy density, site suitability and site-device analysis. It enables stakeholders and the public easy access to the results of tidal current energy resource assessments and site suitability analyses. Results of the initial development showed that it is a promising decision support tool for ocean renewable energy project developments.

  13. Scattered surface charge density: A tool for surface characterization

    KAUST Repository

    Naydenov, Borislav

    2011-11-28

    We demonstrate the use of nonlocal scanning tunneling spectroscopic measurements to characterize the local structure of adspecies in their states where they are significantly less perturbed by the probe, which is accomplished by mapping the amplitude and phase of the scattered surface charge density. As an example, we study single-H-atom adsorption on the n-type Si(100)-(4 × 2) surface, and demonstrate the existence of two different configurations that are distinguishable using the nonlocal approach and successfully corroborated by density functional theory. © 2011 American Physical Society.

  14. Asteroseismology in PLATO. A necessary tool for characterizing planetary systems

    Science.gov (United States)

    Suárez, J. C.; Garrido, R.; Mas-Hesse, J. M.; Rodríguez, J.

    2015-05-01

    Today, the field of stellar physics is witnessing a significant boost thanks to the progress of asteroseismology from space with satellites like CoRoT and Kepler, which will be exploited to its full power with the PLATO mission now under development. Both the study of stellar interiors and the analysis of exo-planetary systems have mutual benefits since not only they share similar techniques for obtaining the data (analysis of light curves) but also the high precision with which today asteroseismology can provide the global parameters of stars is crucial to accurately and precisely characterize the planetary systems. In this contribution I briefly describe this symbiosis.

  15. Hanford Site National Environmental Policy Act (NEPA) Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Duncan, Joanne P.; Burk, Kenneth W.; Chamness, Mickie A.; Fowler, Richard A.; Fritz, Brad G.; Hendrickson, Paul L.; Kennedy, Ellen P.; Last, George V.; Poston, Ted M.; Sackschewsky, Michael R.; Scott, Michael J.; Snyder, Sandra F.; Sweeney, Mark D.; Thorne, Paul D.

    2007-09-27

    This document describes the U.S. Department of Energy’s (DOE) Hanford Site environment. It is intended to provide a consistent description of the Hanford Site for the many environmental documents being prepared by DOE contractors concerning the National Environmental Policy Act (NEPA). No statements regarding significance or environmental consequences are provided. This year’s report is the eighteen revision of the original document published in 1988 and is (until replaced by the nineteenth revision) the only version that is relevant for use in the preparation of Hanford NEPA, State Environmental Policy Act (SEPA), and Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) documents. Two chapters are included in this document (Chapters 4 and 6), numbered to correspond to chapters typically presented in environmental impact statements (EISs) and other Hanford Site NEPA or CERCLA documentation. Chapter 4.0 (Affected Environment) describes Hanford Site climate and meteorology; air quality; geology; hydrology; ecology; cultural, archaeological, and historical resources; socioeconomics; noise; and occupational health and safety. Sources for extensive tabular data related to these topics are provided in the chapter. When possible, subjects are divided into a general description of the characteristics of the Hanford Site, followed by site-specific information, where available, for the 100, 200, 300 and other areas. This division allows the reader to go directly to those sections of particular interest. When specific information on each of these separate areas is not complete or available, the general Hanford Site description should be used. Chapter 6.0 (Statutory and Regulatory Requirements) describes federal and state laws and regulations, DOE directives and permits, and presidential executive orders that are applicable to NEPA documents prepared for Hanford Site activities. Information in Chapter 6 can be adapted and supplemented with

  16. Tus-Ter as a tool to study site-specific DNA replication perturbation in eukaryotes

    DEFF Research Database (Denmark)

    Larsen, Nicolai B; Hickson, Ian D; Mankouri, Hocine W

    2014-01-01

    The high-affinity binding of the Tus protein to specific 21-bp sequences, called Ter, causes site-specific, and polar, DNA replication fork arrest in E coli. The Tus-Ter complex serves to coordinate DNA replication with chromosome segregation in this organism. A number of recent and ongoing studies...... have demonstrated that Tus-Ter can be used as a heterologous tool to generate site-specific perturbation of DNA replication when reconstituted in eukaryotes. Here, we review these recent findings and explore the molecular mechanism by which Tus-Ter mediates replication fork (RF) arrest in the budding...... yeast, S. cerevisiae. We propose that Tus-Ter is a versatile, genetically tractable, and regulatable RF blocking system that can be utilized for disrupting DNA replication in a diverse range of host cells....

  17. Peptidomics as a tool for characterizing bioactive milk peptides.

    Science.gov (United States)

    Giacometti, Jasminka; Buretić-Tomljanović, Alena

    2017-09-01

    Food peptidomics is a sub-field of proteomics that focuses on the composition, interactions, and properties of bioactive peptides present in different food matrices. The milk peptidome is considered a valuable source of a number of biologically active peptides. Increasing use of peptidomic techniques-including the application of high-resolution techniques, such as mass spectrometry-has led to enhancements of our knowledge regarding the health benefits of dairy products, as well as improved monitoring for food control and food safety. Chromatographic techniques, both at the analytical and preparative scale, are used also in the identification of novel peptides, including those synthesized and those obtained through fermentation processes. The present review focuses on peptidomic approaches to the investigation of bioactive milk peptides, including bioinformatics, chemometric tools, and proteomic/peptidomic methods. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Instructions for the use of the methodological tools applicable to polluted sites and soils; Mode d'emploi des outils methodologiques applicables aux sites et sols pollues

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The French policy in the domain of polluted sites and soils is based on a limited number of principles which are: the prevention of future pollutions, the identification of all possible potential risks, a well-suited treatment process which depends on the effective environmental impact and on the intended use of the site. This document aims at identifying the main questions raised by a given situation. It proposed useful methodological tools for the construction of answers to the problems encountered: 1 - general approach (main guidelines for the different steps of the management of a polluted site, different possible approaches); 2 - examples of application (industrial site in use, closing down of an industrial site, accidental situation (recent pollution), fortuitous discovery of a pollution on a site, pollutions with limited surface extension, site involved in a land transaction, polluted site with a sensible use, industrial waste lands). (J.S.)

  19. Site characterization report for the basalt waste isolation project. Volume II

    Energy Technology Data Exchange (ETDEWEB)

    None

    1982-11-01

    The reference location for a repository in basalt for the terminal storage of nuclear wastes on the Hanford Site and the candidate horizons within this reference repository location have been identified and the preliminary characterization work in support of the site screening process has been completed. Fifteen technical questions regarding the qualification of the site were identified to be addressed during the detailed site characterization phase of the US Department of Energy-National Waste Terminal Storage Program site selection process. Resolution of these questions will be provided in the final site characterization progress report, currently planned to be issued in 1987, and in the safety analysis report to be submitted with the License Application. The additional information needed to resolve these questions and the plans for obtaining the information have been identified. This Site Characterization Report documents the results of the site screening process, the preliminary site characterization data, the technical issues that need to be addressed, and the plans for resolving these issues. Volume 2 contains chapters 6 through 12: geochemistry; surface hydrology; climatology, meteorology, and air quality; environmental, land-use, and socioeconomic characteristics; repository design; waste package; and performance assessment.

  20. Summary of 1990 eolian characterization studies, Hanford Site, Washington

    Energy Technology Data Exchange (ETDEWEB)

    Gaylord, D.R.; Stetler, L.D.; Smith, G.D. [Washington State Univ., Pullman, WA (United States); Mars, R.W. [Wyoming Univ., Laramie, WY (United States)

    1993-12-01

    A study of eolian activity was initiated to improve understanding of past climate change and the likely effect of wind on engineered protective barriers at the Hanford Site. Eolian features from a Holocene sand dune field located in the southeastern portion of the Hanford Site were investigated using a variety of field and laboratory techniques including stratigraphic examinations of hand-dug pits, textural and compositional analyses of dune sand and potential source detritus, and air photo interpretations. These investigations were undertaken to evaluate the provenance and eolian dynamics of the sand dunes. Interpretations of sand dune migration using archival air photo stereopairs document a 20% reduction in the volume of active sand dunes (measured from an approximate 15-km{sup 2} test area) between 1948 and 1987. Changes in annual precipitation appear to have influenced active dune migration strongly.

  1. Technical Data Catalog: Yucca Mountain Site Characterization Project. Quarterly supplement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-30

    This report presents reference information contained in the Yucca Mountain Project Automated Technical Data Tracking System. The Department of Energy is seeking to design and maintain a geologic repository for the disposal of high-level radioactive wastes. However, before this repository can be built, the DOE must first do a comprehensive site evaluation. This evaluation is subject to many regulations. This report fulfills the reporting requirements of the Site-Specific Procedural Agreement for Geologic Repository to develop and maintain a catalog of data which will be updated and provided to the Nuclear Regulatory Commission on a quarterly basis. This catalog contains: description of data; time, place, and method of acquisition; and where data may be examined.

  2. Interpreting and Responding to Intensified Site Characterization Results

    Science.gov (United States)

    2011-11-01

    Phase 1 7 , 0 0 0 u g T C E / L 1 0 0 u g T C E / L transmissive pore fraction static pore fraction 2005 Aquifer conditions Alluvial fan Groundwater... dynamic groundwater monitoring) Questions and Discussion Beaver Island, Michigan Impacts and Opportunities • Contaminant mass transport is often...mappings to be successful, however: Low-K zones cannot be treated to compliance. Dynamic groundwater monitoring is a potential solution: Separate site

  3. Resource Conservation and Recovery Act industrial site environmental restoration site characterization plan. Area 6 Steam Cleaning Effluent Ponds

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    This plan presents the strategy for the characterization of the Area 6 South and North Steam Cleaning Effluent Ponds (SCEPs) at the Nevada Test Site (NTS) to be conducted for the US Department of Energy, Nevada Operations Office (DOE/NV), Environmental Restoration Division (ERD). The purposes of the planned activities are to: obtain sufficient, sample analytical data from which further assessment, remediation, and/or closure strategies may be developed for the site; obtain sufficient, sample analytical data for management of investigation-derived waste (IDW). The scope of the characterization may include excavation, drilling, and sampling of soil in and around both ponds; sampling of the excavated material; in situ sampling of the soil at the bottom and on the sides of the excavations as well as within subsurface borings; and conducting sample analysis for both characterization and waste management purposes. Contaminants of concern include RCRA-regulated VOCs and metals.

  4. Functional Characterization of APOBEC-1 Complementation Factor Phosphorylation Sites

    Science.gov (United States)

    Lehmann, David M.; Galloway, Chad A.; MacElrevey, Celeste; Sowden, Mark P.; Wedekind, Joseph E.; Smith, Harold C.

    2007-01-01

    ApoB mRNA editing involves site-specific deamination of cytidine 6666 producing an in-frame translation stop codon. Editing minimally requires APOBEC-1 and APOBEC-1 complementation factor (ACF). Metabolic stimulation of apoB mRNA editing in hepatocytes is associated with serine phosphorylation of ACF localized to editing competent, nuclear 27S editosomes. We demonstrate that activation of protein kinase C (PKC) stimulated editing and enhanced ACF phosphorylation in rat primary hepatocytes. Conversely, activation of protein kinase A (PKA) had no effect on editing. Recombinant PKC efficiently phosphorylated purified ACF64 protein in vitro, whereas PKA did not. Mutagenesis of predicted PKC phosphorylation sites S154 and S368 to alanine inhibited ethanol-stimulated induction of editing suggesting that these sites function in the metabolic regulation of editing. Consistent with this interpretation, substitution of S154 and S368 with aspartic acid stimulated editing to levels comparable to ethanol treatment in control McArdle RH7777 cells. These data suggest that phosphorylation of ACF by PKC may be a key regulatory mechanism of apoB mRNA editing in rat hepatocytes. PMID:17229474

  5. Characterization of atmospheric bioaerosols at 9 sites in Tijuana, Mexico

    Science.gov (United States)

    Hurtado, Lilia; Rodríguez, Guillermo; López, Jonathan; Castillo, J. E.; Molina, Luisa; Zavala, Miguel; Quintana, Penelope J. E.

    2014-10-01

    The atmosphere is not considered a habitat for microorganisms, but can exist in the atmosphere as bioaerosols. These microorganisms in the atmosphere have great environmental importance through their influence on physical processes such as ice nucleation and cloud droplet formation. Pathogenic airborne microorganisms may also have public health consequences. In this paper we analyze the microbial concentration in the air at three sites in Tijuana, Mexico border during the Cal-Mex 2010 air quality campaign and from nine sites over the following year. Samples were collected by impaction with the air analyzer Millipore M Air T, followed by incubation and counting as colony forming units (CFU) of viable colonies. Airborne microbial contamination average levels ranged from a low of 230 ± 130 CFU/m³ in the coastal reference site to an average of 40,100 ± 21,689 CFU/m³ in the Tijuana river valley. We found the highest microbial load in the summer and the lowest values in the winter. Potentially pathogenic bacteria were isolated from the samples, with Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Enterococcus faecalis being most common. This work is the first evaluation of bioaerosols in Tijuana, Mexico.

  6. Inclusion of social indicators in decision support tools for the selection of sustainable site remediation options.

    Science.gov (United States)

    Cappuyns, Valérie

    2016-12-15

    Sustainable remediation requires a balanced decision-making process in which environmental, economic and social aspects of different remediation options are all considered together and the optimum remediation solution is selected. More attention has been paid to the evaluation of environmental and economic aspects, in particular to reduce the human and environmental risks and the remediation costs, to the exclusion of social aspects of remediation. This paper investigates how social aspects are currently considered in sustainability assessments of remediation projects. A selection of decision support tools (DSTs), used for the sustainability assessment of a remediation project, is analyzed to define how social aspects are considered in those tools. The social indicator categories of the Sustainable Remediation Forum - United Kingdom (SuRF-UK), are used as a basis for this evaluation. The consideration of social aspects in the investigated decision support tools is limited, but a clear increase is noticed in more recently developed tools. Among the five social indicator categories defined by SuRF-UK to facilitate a holistic consideration of social aspects of a remediation project only "Human health and safety" is systematically taken into account. "Neighbourhood and locality" is also often addressed, mostly emphasizing the potential disturbance caused by the remediation activities. However, the evaluation of 'Ethics and Equality', Communities and community involvement', and 'Uncertainty and evidence' is often neglected. Nevertheless, concrete examples can be found in some of the investigated tools. Specific legislation, standard procedures, and guidelines that have to be followed in a region or country are mainly been set up in the context of protecting human and ecosystem health, safety and prevention of nuisance. However, they sometimes already include some of the aspects addressed by the social indicators. In this perspective the use of DST to evaluate the

  7. Site characterization progress report: Yucca Mountain, Nevada, October 1, 1990--March 31, 1991; Number 4

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-10-01

    In accordance with the requirements of Section 113 (b) (3) of the Nuclear Waste Policy Act of 1982, as amended (NWPA), the US Department of Energy (DOE) has prepared this report on the progress of site characterization activities at Yucca Mountain, Nevada, for the period October 1, 1990, through March 31, 1991. This report is the fourth in a series of reports that are issued at intervals of approximately six months during site characterization. The report covers a number of initiatives to improve the effectiveness of the site characterization program, and covers continued efforts related to preparatory activities, Study Plans, and performance assessment.

  8. Repetitive, Marker-Free, Site-Specific Integration as a Novel Tool for Multiple Chromosomal Integration of DNA

    DEFF Research Database (Denmark)

    Petersen, Kia Vest; Martinussen, Jan; Jensen, Peter Ruhdal

    2013-01-01

    of a minimal bacterial attachment site (attBmin), two mutated loxP sequences (lox66 and lox71) allowing for removal of undesirable vector elements (antibiotic resistance marker), and a counterselection marker (oroP) for selection of loxP recombination on the pKV6 vector. When transformed into L. lactis......We present a tool for repetitive, marker-free, site-specific integration in Lactococcus lactis, in which a nonreplicating plasmid vector (pKV6) carrying a phage attachment site (attP) can be integrated into a bacterial attachment site (attB). The novelty of the tool described here is the inclusion...

  9. Kinematic and electromyographic tools for characterizing movement disorders in mice.

    Science.gov (United States)

    Scholle, Hans C; Jinnah, H A; Arnold, Dirk; Biedermann, Frank H W; Faenger, Bernd; Grassme, Roland; Hess, Ellen J; Schumann, Nikolaus P

    2010-02-15

    Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans. (c) 2010 Movement Disorder Society.

  10. Conformational characterization of disulfide bonds: a tool for protein classification.

    Science.gov (United States)

    Marques, José Rui Ferreira; da Fonseca, Rute R; Drury, Brett; Melo, André

    2010-12-07

    Throughout evolution, mutations in particular regions of some protein structures have resulted in extra covalent bonds that increase the overall robustness of the fold: disulfide bonds. The two strategically placed cysteines can also have a more direct role in protein function, either by assisting thiol or disulfide exchange, or through allosteric effects. In this work, we verified how the structural similarities between disulfides can reflect functional and evolutionary relationships between different proteins. We analyzed the conformational patterns of the disulfide bonds in a set of disulfide-rich proteins that included twelve SCOP superfamilies: thioredoxin-like and eleven superfamilies containing small disulfide-rich proteins (SDP). The twenty conformations considered in the present study were characterized by both structural and energetic parameters. The corresponding frequencies present diverse patterns for the different superfamilies. The least-strained conformations are more abundant for the SDP superfamilies, while the "catalytic" +/-RHook is dominant for the thioredoxin-like superfamily. The "allosteric" -RHSaple is moderately abundant for BBI, Crisp and Thioredoxin-like superfamilies and less frequent for the remaining superfamilies. Using a hierarchical clustering analysis we found that the twelve superfamilies were grouped in biologically significant clusters. In this work, we carried out an extensive statistical analysis of the conformational motifs for the disulfide bonds present in a set of disulfide-rich proteins. We show that the conformational patterns observed in disulfide bonds are sufficient to group proteins that share both functional and structural patterns and can therefore be used as a criterion for protein classification. Copyright © 2010 Elsevier Ltd. All rights reserved.

  11. An overview of geophysical technologies appropriate for characterization and monitoring at fractured-rock sites

    Science.gov (United States)

    Geophysical methods are used increasingly for characterization and monitoring at remediation sites in fractured-rock aquifers. The complex heterogeneity of fractured rock poses enormous challenges to groundwater remediation professionals, and new methods are needed to cost-effect...

  12. Allocation of DSST in the New implementation of Tastrodyweb Tools Web-site

    Science.gov (United States)

    San Juan, J. F.; Lara, M.; López, R.; López, L. M.; Weeden, B.; Cefola, P. J.

    2012-09-01

    The Draper Semianalytic Satellite Theory (DSST) is a semianalytic orbit propagator, which was carried out on Fortran to run from a command line interface. The construction of DSST began at the Computer Sciences Corporation and continued at the Draper Laboratory in the late 1970's and early 1980's. There are two versions of this application. One of them can be found as an option within the Goddard Trajectory Determination System (GTDS), whereas the other is available as a Standalone Orbit Propagator Package. Both versions are constantly evolving and updating. This constant evolution and updating allows DSST to take into account a wide variety of perturbation forces, which can be selected by means of a non-trivial options system at run time, and makes DSST a useful tool for performing short-term high accuracy orbit determination as well as long-term evolution. DSST has been included as part of an open source project for Space Situational Awareness and space object catalog work. On the last IAC 2011 a first step was taken in this sense and DSST was included on the tastrody Web-Site prototype [3, 4], which provided DSST with a friendly web interface, thus simplifying its use for both expert and non-expert users. However, this prototype has evolved into a stable platform based on the Drupal open source content management system (http://drupal.org Drupal), which simplifies the integration of our own application server. Drupal is supported by a large group of developers and users. Furthermore, a significant number of web-sites have been created using Drupal. In this work we present the integration of DSST in the new web-site, the new facilities provide by this platform to create the research community based on DSST and the comparison tests between the GTDS DSST, DSST Standalone and DSST Web version. These tests will be available in order to facilitate the user with better understanding of DSST. REFERENCES [1] J. G. Neelon, P. J. Cefola, and R. J. Proulx, Current

  13. Mobile laboratories: An innovative and efficient solution for radiological characterization of sites under or after decommissioning.

    Science.gov (United States)

    Goudeau, V; Daniel, B; Dubot, D

    2017-04-21

    During the operation and the decommissioning of a nuclear site the operator must assure the protection of the workers and the environment. It must furthermore identify and classify the various wastes, while optimizing the associated costs. At all stages of the decommissioning radiological measurements are performed to determine the initial situation, to monitor the demolition and clean-up, and to verify the final situation. Radiochemical analysis is crucial for the radiological evaluation process to optimize the clean-up operations and to the respect limits defined with the authorities. Even though these types of analysis are omnipresent in activities such as the exploitation, the monitoring, and the cleaning up of nuclear plants, some nuclear sites do not have their own radiochemical analysis laboratory. Mobile facilities can overcome this lack when nuclear facilities are dismantled, when contaminated sites are cleaned-up, or in a post-accident situation. The current operations for the characterization of radiological soils of CEA nuclear facilities, lead to a large increase of radiochemical analysis. To manage this high throughput of samples in a timely manner, the CEA has developed a new mobile laboratory for the clean-up of its soils, called SMaRT (Shelter for Monitoring and nucleAR chemisTry). This laboratory is dedicated to the preparation and the radiochemical analysis (alpha, beta, and gamma) of potentially contaminated samples. In this framework, CEA and Eichrom laboratories has signed a partnership agreement to extend the analytical capacities and bring on site optimized and validated methods for different problematic. Gamma-emitting radionuclides can usually be measured in situ as little or no sample preparation is required. Alpha and beta-emitting radionuclides are a different matter. Analytical chemistry laboratory facilities are required. Mobile and transportable laboratories equipped with the necessary tools can provide all that is needed. The main

  14. 76 FR 13665 - Cambridge Tool & Die, Including On-Site Leased Workers From Action Total Staffing, Cambridge, OH...

    Science.gov (United States)

    2011-03-14

    ... Employment and Training Administration Cambridge Tool & Die, Including On-Site Leased Workers From Action Total Staffing, Cambridge, OH; Amended Certification Regarding Eligibility To Apply for Worker... ] Assistance on January 13, 2011, applicable to workers of Cambridge Tool & Die, Cambridge, Ohio. The workers...

  15. ON-LINE TOOLS FOR PROPER VERTICAL POSITIONING OF VERTICAL SAMPLING INTERVALS DURING SITE ASSESSMENT: MEETING IN MONTGOMERY, ALABAMA

    Science.gov (United States)

    This presentation, On-Line Tools for Proper Vertical Positioning of Sampling Intervals During Site Assessment, describes an approach to locating monitoring wells that is based on application of ground water models. The ideal use of both the model and site assessment funds is to ...

  16. Characterizing the Mineralogy of Potential Lunar Landing Sites

    Science.gov (United States)

    Pieters, Carle; Head, James W., III; Mustard, Jack; Boardman, Joe; Buratti, Bonnie; Clark, Roger; Green, Rob; Head, James W, III; McCord, Thomas B.; Mustard, Jack; hide

    2006-01-01

    Many processes active on the early Moon are common to most terrestrial planets, including the record of early and late impact bombardment. The Moon's surface provides a record of the earliest era of terrestrial planet evolution, and the type and composition of minerals that comprise a planetary surface are a direct result of the initial composition and subsequent thermal and physical processing. Lunar mineralogy seen today is thus a direct record of the early evolution of the lunar crust and subsequent geologic processes. Specifically, the distribution and concentration of specific minerals is closely tied to magma ocean products, lenses of intruded or remelted plutons, basaltic volcanism and fire-fountaining, and any process (e.g. cratering) that might redistribute or transform primary and secondary lunar crustal materials. The association of several lunar minerals with key geologic processes is illustrated in Figure 1. The geologic history of potential landing sites on the Moon can be read from the character and context of local mineralogy.

  17. Landfill Site Selection by AHP Based Multi-criteria Decision Making Tool: A Case Study in Kolkata, India

    Science.gov (United States)

    Majumdar, Ankush; Hazra, Tumpa; Dutta, Amit

    2017-09-01

    This work presents a Multi-criteria Decision Making (MCDM) tool to select a landfill site from three candidate sites proposed for Kolkata Municipal Corporation (KMC) area that complies with accessibility, receptor, environment, public acceptability, geological and economic criteria. Analytical Hierarchy Process has been used to solve the MCDM problem. Suitability of the three sites (viz. Natagachi, Gangajoara and Kharamba) as landfills as proposed by KMC has been checked by Landfill Site Sensitivity Index (LSSI) as well as Economic Viability Index (EVI). Land area availability for disposing huge quantity of Municipal Solid Waste for the design period has been checked. Analysis of the studied sites show that they are moderately suitable for landfill facility construction as both LSSI and EVI scores lay between 300 and 750. The proposed approach represents an effective MCDM tool for siting sanitary landfill in growing metropolitan cities of developing countries like India.

  18. Landfill Site Selection by AHP Based Multi-criteria Decision Making Tool: A Case Study in Kolkata, India

    Science.gov (United States)

    Majumdar, Ankush; Hazra, Tumpa; Dutta, Amit

    2017-07-01

    This work presents a Multi-criteria Decision Making (MCDM) tool to select a landfill site from three candidate sites proposed for Kolkata Municipal Corporation (KMC) area that complies with accessibility, receptor, environment, public acceptability, geological and economic criteria. Analytical Hierarchy Process has been used to solve the MCDM problem. Suitability of the three sites (viz. Natagachi, Gangajoara and Kharamba) as landfills as proposed by KMC has been checked by Landfill Site Sensitivity Index (LSSI) as well as Economic Viability Index (EVI). Land area availability for disposing huge quantity of Municipal Solid Waste for the design period has been checked. Analysis of the studied sites show that they are moderately suitable for landfill facility construction as both LSSI and EVI scores lay between 300 and 750. The proposed approach represents an effective MCDM tool for siting sanitary landfill in growing metropolitan cities of developing countries like India.

  19. White Oak Creek Embayment site characterization and contaminant screening analysis

    Energy Technology Data Exchange (ETDEWEB)

    Blaylock, B.G.; Ford, C.J.; Frank, M.L.; Hoffman, F.O.; Hook, L.A.

    1993-01-01

    Analyses of sediment samples collected near the mouth of White Oak Creek during the summer of 1990 revealed [sup 137]Cs concentrations [> 10[sup 6] Bq/kg dry wt (> 10[sup 4] pCi/g dry wt)] near the sediment surface. Available evidence indicates that these relatively high concentrations of [sup 137]Cs now at the sediment surface were released from White Oak Dam in the mid-1950s and had accumulated at depositionalsites in the embayment. These accumulated sediments are being eroded and transported downstream primarily during winter low-water levels by flood events and by a combination of normal downstream flow and the water turbulence created by the release of water from Melton Hill Dam during hydropower generation cycles. This report provides a more thorough characterization of the extent of contamination in WOCE than was previously available. Environmental samples collected from WOCE were analyzed for organic, inorganic, and radiological contaminants in fish, water, and sediment. These results were used to conduct a human health effects screening analysis. Walkover radiation surveys conducted inside the fenced area surrounding the WOCE at summer-pool (741 ft MSL) and at winter-pool (733 ft MSL) level, indicated a maximum exposure rate of 3 mR h[sup 1] 1 m above the soil surface.

  20. Use of Electrical Conductivity Logging to Characterize the Geological Context of Releases at UST Sites

    Science.gov (United States)

    Risk is the combination of hazard and exposure. Risk characterization at UST release sites has traditionally emphasized hazard (presence of residual fuel) with little attention to exposure. Exposure characterization often limited to a one-dimensional model such as the RBCA equa...

  1. Third-generation site characterization: Cryogenic core collection, nuclear magnetic resonance, and electrical resistivity

    Science.gov (United States)

    Kiaalhosseini, Saeed

    In modern contaminant hydrology, management of contaminated sites requires a holistic characterization of subsurface conditions. Delineation of contaminant distribution in all phases (i.e., aqueous, non-aqueous liquid, sorbed, and gas), as well as associated biogeochemical processes in a complex heterogeneous subsurface, is central to selecting effective remedies. Arguably, a factor contributing to the lack of success of managing contaminated sites effectively has been the limitations of site characterization methods that rely on monitoring wells and grab sediment samples. The overarching objective of this research is to advance a set of third-generation (3G) site characterization methods to overcome shortcomings of current site characterization techniques. 3G methods include 1) cryogenic core collection (C3) from unconsolidated geological subsurface to improve recovery of sediments and preserving key attributes, 2) high-throughput analysis (HTA) of frozen core in the laboratory to provide high-resolution, depth discrete data of subsurface conditions and processes, 3) resolution of non-aqueous phase liquid (NAPL) distribution within the porous media using a nuclear magnetic resonance (NMR) method, and 4) application of a complex resistivity method to track NAPL depletion in shallow geological formation over time. A series of controlled experiments were conducted to develop the C 3 tools and methods. The critical aspects of C3 are downhole circulation of liquid nitrogen via a cooling system, the strategic use of thermal insulation to focus cooling into the core, and the use of back pressure to optimize cooling. The C3 methods were applied at two contaminated sites: 1) F.E. Warren (FEW) Air Force Base near Cheyenne, WY and 2) a former refinery in the western U.S. The results indicated that the rate of core collection using the C3 methods is on the order of 30 foot/day. The C3 methods also improve core recovery and limits potential biases associated with flowing sands

  2. Site characterization techniques used at a low-level waste shallow land burial field demonstration facility

    Energy Technology Data Exchange (ETDEWEB)

    Davis, E.C.; Boegly, W.J. Jr.; Rothschild, E.R.; Spalding, B.P.; Vaughan, N.D.; Haase, C.S.; Huff, D.D.; Lee, S.Y.; Walls, E.C.; Newbold, J.D.

    1984-07-01

    The Environmental Sciences Division of the Oak Ridge National Laboratory has been investigating improved shallow land burial technology for application in the humd eastern United States. As part of this effort, a field demonstration facility (Engineered Test Facility, or ETF) has been established in Solid Waste Storage Area 6 for purposes of investigatig the ability of two trench treatments (waste grouting prior to cover emplacement and waste isolation with trench liners) to prevent water-waste contact and thus minimize waste leaching. As part of the experimental plan, the ETF site has been characterized for purposes of constructing a hydrologic model. Site characterization is an extremely important component of the waste disposal site selection process; during these activities, potential problems, which might obviate the site from further consideration, may be found. This report describes the ETF site characterization program and identifies and, where appropriate, evaluates those tests that are of most value in model development. Specific areas covered include site geology, soils, and hydrology. Each of these areas is further divided into numerous subsections, making it easy for the reader to examine a single area of interest. Site characterization is a multidiscipliary endeavor with voluminous data, only portions of which are presented and analyzed here. The information in this report is similar to that which will be required of a low-level waste site developer in preparing a license application for a potential site in the humid East, (a discussion of licensing requirements is beyond its scope). Only data relevant to hydrologic model development are included, anticipating that many of these same characterization methods will be used at future disposal sites with similar water-related problems.

  3. Characterization of aerosol particles at the forested site in Lithuania

    Science.gov (United States)

    Rimselyte, I.; Garbaras, A.; Kvietkus, K.; Remeikis, V.

    2009-04-01

    Atmospheric particulate matter (PM), especially fine particles (particles with aerodynamic diameter less than 1 m, PM1), has been found to play an important role in global climate change, air quality, and human health. The continuous study of aerosol parameters is therefore imperative for better understanding the environmental effects of the atmospheric particles, as well as their sources, formation and transformation processes. The particle size distribution is particularly important, since this physical parameter determines the mass and number density, lifetime and atmospheric transport, or optical scattering behavior of the particles in the atmosphere (Jaenicke, 1998). Over the years several efforts have been made to improve the knowledge about the chemical composition of atmospheric particles as a function of size (Samara and Voutsa, 2005) and to characterize the relative contribution of different components to the fine particulate matter. It is well established that organic materials constitute a highly variable fraction of the atmospheric aerosol. This fraction is predominantly found in the fine size mode in concentrations ranging from 10 to 70% of the total dry fine particle mass (Middlebrook et al., 1998). Although organic compounds are major components of the fine particles, the composition, formation mechanism of organic aerosols are not well understood. This is because particulate organic matter is part of a complex atmospheric system with hundreds of different compounds, both natural and anthropogenic, covering a wide range of chemical properties. The aim of this study was to characterize the forest PM1, and investigate effects of air mass transport on the aerosol size distribution and chemical composition, estimate and provide insights into the sources and characteristics of carbonaceous aerosols through analysis ^13C/12C isotopic ratio as a function of the aerosol particles size. The measurements were performed at the Rugšteliškis integrated

  4. Social Networking Site Usage Among Childhood Cancer Survivors - A Potential Tool for Research Recruitment?

    Science.gov (United States)

    Seltzer, Erica D.; Stolley, Melinda R.; Mensah, Edward K.; Sharp, Lisa K.

    2014-01-01

    Purpose The recent and rapid growth of social networking site (SNS) use presents a unique public health opportunity to develop effective strategies for the recruitment of hard-to-reach participants for cancer research studies. This survey investigated childhood cancer survivors’ reported use of SNS such as facebook or MySpace and their perceptions of using SNS, for recruitment into survivorship research. Methods Sixty White, Black and Hispanic, adult childhood cancer survivors (range 18 – 48 years of age) that were randomly selected from a larger childhood cancer study, the Chicago Healthy Living Study (CHLS), participated in this pilot survey. Telephone surveys were conducted to understand current SNS activity and attitudes towards using SNS as a cancer research recruitment tool. Results Seventy percent of participants reported SNS usage of which 80% were at least weekly users and 79 % reported positive attitudes towards the use of SNS as a recruitment tool for survivorship research. Conclusions and implications for cancer survivors The results of this pilot study revealed that SNS use was high and regular among the childhood cancer survivors sampled. Most had positive attitudes towards using SNS for recruitment of research. The results of this pilot survey suggest that SNS may offer an alternative approach for recruitment of childhood cancer survivors into research. PMID:24532046

  5. Molecular characterization of the microsomal tamoxifen binding site.

    Science.gov (United States)

    Kedjouar, Blandine; de Médina, Philippe; Oulad-Abdelghani, Mustapha; Payré, Bruno; Silvente-Poirot, Sandrine; Favre, Gilles; Faye, Jean-Charles; Poirot, Marc

    2004-08-06

    Tamoxifen is a selective estrogen receptor modulator widely used for the prophylactic treatment of breast cancer. In addition to the estrogen receptor (ER), tamoxifen binds with high affinity to the microsomal antiestrogen binding site (AEBS), which is involved in ER-independent effects of tamoxifen. In the present study, we investigate the modulation of the biosynthesis of cholesterol in tumor cell lines by AEBS ligands. As a consequence of the treatment with the antitumoral drugs tamoxifen or PBPE, a selective AEBS ligand, we show that tumor cells produced a significant concentration- and time-dependent accumulation of cholesterol precursors. Sterols have been purified by HPLC and gas chromatography, and their chemical structures determined by mass spectrometric analysis. The major metabolites identified were 5alpha-cholest-8-en-3beta-ol for tamoxifen treatment and 5alpha-cholest-8-en-3beta-ol and cholesta-5,7-dien-3beta-ol, for PBPE treatment, suggesting that these AEBS ligands affect at least two enzymatic steps: the 3beta-hydroxysterol-Delta8-Delta7-isomerase and the 3beta-hydroxysterol-Delta7-reductase. Steroidal antiestrogens such as ICI 182,780 and RU 58,668 did not affect these enzymatic steps, because they do not bind to the AEBS. Transient co-expression of human 3beta-hydroxysterol-Delta8-Delta7-isomerase and 3beta-hydroxysterol-Delta7-reductase and immunoprecipitation experiments showed that both enzymes were required to reconstitute the AEBS in mammalian cells. Altogether, these data provide strong evidence that the AEBS is a hetero-oligomeric complex including 3beta-hydroxysterol-Delta8-Delta7-isomerase and the 3beta-hydroxysterol-Delta7-reductase as subunits that are necessary and sufficient for tamoxifen binding in mammary cells. Furthermore, because selective AEBS ligands are antitumoral compounds, these data suggest a link between cholesterol metabolism at a post-lanosterol step and tumor growth control. These data afford both the identification

  6. New tools for basin scale river ice characterization from radar data

    Science.gov (United States)

    Gauthier, Y.; Bernier, M.; Poulin, J.; Uusikivi, J.; Duguay, C.

    2012-04-01

    In recent years, a number of river ice services have been developed to support flood forecasting and ice jam early warnings, using radar satellite imagery. Some approaches are already used operationally by water or public safety authorities for river ice monitoring. However, there is still a need to further improve these services by enhancing the classification accuracy and the characterization of river ice dynamics and by making better use of the image-derived information. This aspect is investigated within the STSE North Hydrology project (Support To Science Element - European Space Agency), which global objectives is to exploit earth observation technology, models and in situ data to improve the characterization of river and lake ice processes and their contribution to the Northern Hydrology system. The river ice work builds on the expertise of the FRAZIL system, developed at INRS. Improvements are made to the IceMAP algorithm (Ice Mapping Automated Procedure) for use with dual polarization ASAR data. Ambiguities in the presence of water surface roughness (wind or rapids) are reduced. New tools are developed to automatically derive added-value information from the radar ice maps: 1) the Ice Cover Profiler gives a longitudinal view of the ice surface concentrations; 2) the Ice Change Detector detects signs of melting, signs of break-up, signs of freeze-up and signs of consolidation and 3) the ice front monitor indicates the probable location of the ice front. Output information is evaluated for use with breakup date forecasting models and other needs of the Finnish Environment Institute (SYKE). The primary testing site for this project is the Tornionjoki/Torne älv River, a river at the border between Finland and Sweden. But other sites were included as well (Koksoak, Chaudiere and Peace Rivers (Canada) as the main challenge remains the availability of both images of river ice and validation data over various conditions. Archived and new ASAR images were used for

  7. Postclosure performance assessment of the SCP (Site Characterization Plan) conceptual design for horizontal emplacement: Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1987-08-01

    This report is a preliminary postclosure performance assessment of the repository design specified in the Site Characterization Plan Conceptual Design Report (SCP-CDR) for horizontal emplacement of high-level nuclear waste. At the time that these analyses were done, horizontal emplacement was the preferred orientation for the waste packages but vertical emplacement is now the reference design. This assessment consists of (1) a review of the regulatory requirements and strategy to demonstrate compliance with these requirements, (2) an analysis of the performance of the total repository system, (3) an analysis of the thermomechanical behavior of the repository, (4) an analysis of brine mobility in the repository, (5) an analysis of the waste package performance, (6) an analysis of the performance of seals, and (7) comments on the sensitivity of the various performance measures to uncertainties in the data and models. These are preliminary analyses and, in most cases, involve bounding calculations of the repository behavior. They have several purposes including (1) assessing how well this conceptual design ''measures up'' against requirements, (2) gaining experience in implementing the performance assessment strategy and tools and thereby learning where improvements are needed, (3) helping to identify needed data, and (4) helping to indicate required design modifications. 26 refs., 40 figs., 20 tabs.

  8. Activity-Based Probes for Isoenzyme- and Site-Specific Functional Characterization of Glutathione S -Transferases

    Energy Technology Data Exchange (ETDEWEB)

    Stoddard, Ethan G. [Chemical Biology and Exposure; Killinger, Bryan J. [Chemical Biology and Exposure; Nair, Reji N. [Chemical Biology and Exposure; Sadler, Natalie C. [Chemical Biology and Exposure; Volk, Regan F. [Chemical Biology and Exposure; Purvine, Samuel O. [Chemical Biology and Exposure; Shukla, Anil K. [Chemical Biology and Exposure; Smith, Jordan N. [Chemical Biology and Exposure; Wright, Aaron T. [Chemical Biology and Exposure

    2017-11-01

    Glutathione S-transferases (GSTs) comprise a highly diverse family of phase II drug metabolizing enzymes whose shared function is the conjugation of reduced glutathione to various endo- and xenobiotics. Although the conglomerate activity of these enzymes can be measured by colorimetric assays, measurement of the individual contribution from specific isoforms and their contribution to the detoxification of xenobiotics in complex biological samples has not been possible. For this reason, we have developed two activity-based probes that characterize active glutathione transferases in mammalian tissues. The GST active site is comprised of a glutathione binding “G site” and a distinct substrate binding “H site”. Therefore, we developed (1) a glutathione-based photoaffinity probe (GSH-ABP) to target the “G site”, and (2) a probe designed to mimic a substrate molecule and show “H site” activity (GST-ABP). The GSH-ABP features a photoreactive moiety for UV-induced covalent binding to GSTs and glutathione-binding enzymes. The GST-ABP is a derivative of a known mechanism-based GST inhibitor that binds within the active site and inhibits GST activity. Validation of probe targets and “G” and “H” site specificity was carried out using a series of competitors in liver homogenates. Herein, we present robust tools for the novel characterization of enzyme- and active site-specific GST activity in mammalian model systems.

  9. Site characterization progress report: Yucca Mountain, Nevada, April 1, 1993--September 30, 1993, No. 9

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-02-01

    In accordance with requirements of Section 113(b)(3) of the Nuclear Waste Policy Act of 1982, as amended, and 10 CFR 60.18(g), the U.S. Department of Energy has prepared this report on the progress of site characterization activities at Yucca Mountain, Nevada, for the period April 1, 1993, through September 30, 1993. This report is the ninth in a series issued at intervals of approximately six months during site characterization of Yucca Mountain as a possible site for a geologic repository for the permanent disposal of high-level radioactive waste. Also included in this report are activities such as public outreach and international programs that are not formally part of the site characterization process. Information on these activities is provided to report on all aspects of the Yucca Mountain studies.

  10. Site characterization progress report: Yucca Mountain, Nevada, October 1, 1992--March 31, 1993, No. 8

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-08-01

    In accordance with requirements of Section 113(b)(3) of the Nuclear Waste Policy Act of 1982, as amended, and 10 CFR 60.18(g), the US Department of Energy has prepared this report on the progress of site characterization activities at Yucca Mountain, Nevada, for the period October 1, 1992, through March 31, 1993. This report is the eighth in a series issued at intervals of approximately six months during site characterization of Yucca Mountain as a possible site for a geologic repository for the permanent disposal of high-level radioactive waste. Also included in this report are activities such as public outreach and international programs that are not formally part of the site characterization process. Information on these activities is provided to report on all aspects of the Yucca Mountain studies.

  11. Borehole Tool for the Comprehensive Characterization of Hydrate-bearing Sediments

    Energy Technology Data Exchange (ETDEWEB)

    Dai, Sheng [Georgia Inst. of Technology, Atlanta, GA (United States); Santamarina, J. Carlos [Georgia Inst. of Technology, Atlanta, GA (United States); King Abdullah Univ. of Science and Technology (KAUST), Thuwal (Saudi Arabia)

    2017-12-30

    Reservoir characterization and simulation require reliable parameters to anticipate hydrate deposits responses and production rates. The acquisition of the required fundamental properties currently relies on wireline logging, pressure core testing, and/or laboratory observations of synthesized specimens, which are challenged by testing capabilities and innate sampling disturbances. The project reviews hydrate-bearing sediments, properties, and inherent sampling effects, albeit lessen with the developments in pressure core technology, in order to develop robust correlations with index parameters. The resulting information is incorporated into a tool for optimal field characterization and parameter selection with uncertainty analyses. Ultimately, the project develops a borehole tool for the comprehensive characterization of hydrate-bearing sediments at in situ, with the design recognizing past developments and characterization experience and benefited from the inspiration of nature and sensor miniaturization.

  12. Borehole Tool for the Comprehensive Characterization of Hydrate-bearing Sediments

    KAUST Repository

    Dai, Sheng

    2018-02-01

    Reservoir characterization and simulation require reliable parameters to anticipate hydrate deposits responses and production rates. The acquisition of the required fundamental properties currently relies on wireline logging, pressure core testing, and/or laboratory ob-servations of synthesized specimens, which are challenged by testing capabilities and in-nate sampling disturbances. The project reviews hydrate-bearing sediments, properties, and inherent sampling effects, albeit lessen with the developments in pressure core technology, in order to develop robust correlations with index parameters. The resulting information is incorporated into a tool for optimal field characterization and parameter selection with un-certainty analyses. Ultimately, the project develops a borehole tool for the comprehensive characterization of hydrate-bearing sediments at in situ, with the design recognizing past developments and characterization experience and benefited from the inspiration of nature and sensor miniaturization.

  13. Drift design methodology and preliminary application for the Yucca Mountain Site Characterization Project; Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Hardy, M.P. [Agapito (J.F.T.) and Associates, Inc., Grand Junction, CO (United States); Bauer, S.J. [Sandia National Labs., Albuquerque, NM (United States)

    1991-12-01

    Excavation stability in an underground nuclear waste repository is required during construction, emplacement, retrieval (if required), and closure phases to ensure worker health and safety, and to prevent development of potential pathways for radionuclide migration in the post-closure period. Stable excavations are developed by appropriate excavation procedures, design of the room shape, design and installation of rock support reinforcement systems, and implementation of appropriate monitoring and maintenance programs. In addition to the loads imposed by the in situ stress field, the repository drifts will be impacted by thermal loads developed after waste emplacement and, periodically, by seismic loads from naturally occurring earthquakes and underground nuclear events. A priori evaluation of stability is required for design of the ground support system, to confirm that the thermal loads are reasonable, and to support the license application process. In this report, a design methodology for assessing drift stability is presented. This is based on site conditions, together with empirical and analytical methods. Analytical numerical methods are emphasized at this time because empirical data are unavailable for excavations in welded tuff either at elevated temperatures or under seismic loads. The analytical methodology incorporates analysis of rock masses that are systematically jointed, randomly jointed, and sparsely jointed. In situ thermal and seismic loads are considered. Methods of evaluating the analytical results and estimating ground support requirements for all the full range of expected ground conditions are outlines. The results of a preliminary application of the methodology using the limited available data are presented. 26 figs., 55 tabs.

  14. Characterization of the geology, geochemistry, and microbiology of the radio frequency heating demonstration site at the Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Eddy Dilek, C.A.; Jarosch, T.R.; Fliermans, C.B.; Looney, B.B.; Parker, W.H.

    1993-08-01

    The overall objective of the Integrated Demonstration Project for the Remediation of Organics at Nonarid Sites at the Savannah River Site (SRS) is to evaluate innovative remediation, characterization, and monitoring systems to facilitate restoration of contaminated sites. The first phase of the demonstration focused on the application and development of in situ air stripping technologies to remediate sediments and groundwater contaminated with volatile organic compounds (VOCs). The second phase focused on the enhancement of the in situ air stripping process by adding selected nutrients to stimulate naturally occurring microorganisms that degrade VOCs. The purpose of the third phase was to evaluate the use of heating technologies [radio frequency (rf) and ohmic heating] to enhance the removal of contamination from clay layers where mass transfer is limited. The objective of this report is to document pretest and post-test data collected in support of the rf heating demonstration. The following data are discussed in this report: (1) a general description of the site including piezometers and sensors installed to monitor the remedial process; (2) stratigraphy, lithology, and a detailed geologic cross section of the study site; (3) tabulations of pretest and post-test moisture and VOC content of the sediments; (4) sampling and analysis procedures for sediment samples; (5) microbial abundance and diversity; (6) three-dimensional images of pretest and post-test contaminant distribution; (7) volumetric calculations.

  15. Characterization ReportOperational Closure Covers for the Area 5 Radioactive Waste Management Site at the Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Bechtel Nevada Geotechnical Sciences

    2005-06-01

    Bechtel Nevada (BN) manages two low-level Radioactive Waste Management Sites (RWMSs) at the Nevada Test Site (NTS) for the U.S. Department of Energy (DOE) National Nuclear Security Administration Nevada Site Office (NNSA/NSO). The Area 3 RWMS is located in south-central Yucca Flat and the Area 5 RWMS is located about 15 miles south, in north-central Frenchman Flat. Though located in two separate topographically closed basins, they are similar in climate and hydrogeologic setting. The Area 5 RWMS uses engineered shallow-land burial cells to dispose of packaged waste, while the Area 3 RWMS uses subsidence craters formed from underground testing of nuclear weapons for the disposal of packaged and unpackaged bulk waste. Over the next several decades, most waste disposal units at both the Area 3 and Area 5 RWMSs are anticipated to be closed. Closure of the Area 3 and Area 5 RWMSs will proceed through three phases: operational closure, final closure, and institutional control. Many waste disposal units at the Area 5RWMS are operationally closed and final closure has been placed on one unit at the Area 3 RWMS (U-3ax/bl). Because of the similarities between the two sites (e.g., type of wastes, environmental factors, operational closure cover designs, etc.), many characterization studies and data collected at the Area 3 RWMS are relevant and applicable to the Area 5 RWMS. For this reason, data and closure strategies from the Area 3 RWMS are referred to as applicable. This document is an interim Characterization Report – Operational Closure Covers, for the Area 5 RWMS. The report briefly describes the Area 5 RWMS and the physical environment where it is located, identifies the regulatory requirements, reviews the approach and schedule for closing, summarizes the monitoring programs, summarizes characterization studies and results, and then presents conclusions and recommendations.

  16. A new spatial multi-criteria decision support tool for site selection for implementation of managed aquifer recharge.

    Science.gov (United States)

    Rahman, M Azizur; Rusteberg, Bernd; Gogu, R C; Lobo Ferreira, J P; Sauter, Martin

    2012-05-30

    This study reports the development of a new spatial multi-criteria decision analysis (SMCDA) software tool for selecting suitable sites for Managed Aquifer Recharge (MAR) systems. The new SMCDA software tool functions based on the combination of existing multi-criteria evaluation methods with modern decision analysis techniques. More specifically, non-compensatory screening, criteria standardization and weighting, and Analytical Hierarchy Process (AHP) have been combined with Weighted Linear Combination (WLC) and Ordered Weighted Averaging (OWA). This SMCDA tool may be implemented with a wide range of decision maker's preferences. The tool's user-friendly interface helps guide the decision maker through the sequential steps for site selection, those steps namely being constraint mapping, criteria hierarchy, criteria standardization and weighting, and criteria overlay. The tool offers some predetermined default criteria and standard methods to increase the trade-off between ease-of-use and efficiency. Integrated into ArcGIS, the tool has the advantage of using GIS tools for spatial analysis, and herein data may be processed and displayed. The tool is non-site specific, adaptive, and comprehensive, and may be applied to any type of site-selection problem. For demonstrating the robustness of the new tool, a case study was planned and executed at Algarve Region, Portugal. The efficiency of the SMCDA tool in the decision making process for selecting suitable sites for MAR was also demonstrated. Specific aspects of the tool such as built-in default criteria, explicit decision steps, and flexibility in choosing different options were key features, which benefited the study. The new SMCDA tool can be augmented by groundwater flow and transport modeling so as to achieve a more comprehensive approach to the selection process for the best locations of the MAR infiltration basins, as well as the locations of recovery wells and areas of groundwater protection. The new spatial

  17. Oak Ridge K-25 Site Technology Logic Diagram. Volume 3, Technology evaluation data sheets; Part A, Characterization, decontamination, dismantlement

    Energy Technology Data Exchange (ETDEWEB)

    Fellows, R.L. [ed.

    1993-02-26

    The Oak Ridge K-25 Technology Logic Diagram (TLD), a decision support tool for the K-25 Site, was developed to provide a planning document that relates environmental restoration and waste management problems at the Oak Ridge K-25 Site to potential technologies that can remediate these problems. The TLD technique identifies the research necessary to develop these technologies to a state that allows for technology transfer and application to waste management, remedial action, and decontamination and decommissioning activities. The TLD consists of four separate volumes-Vol. 1, Vol. 2, Vol. 3A, and Vol. 3B. Volume 1 provides introductory and overview information about the TLD. Volume 2 contains logic diagrams. Volume 3 has been divided into two separate volumes to facilitate handling and use. This report is part A of Volume 3 concerning characterization, decontamination, and dismantlement.

  18. Threatened and endangered wildlife species of the Hanford Site related to CERCLA characterization activities

    Energy Technology Data Exchange (ETDEWEB)

    Fitzner, R.E. [Pacific Northwest Lab., Richland, WA (United States); Weiss, S.G.; Stegen, J.A. [Westinghouse Hanford Co., Richland, WA (United States)

    1994-06-01

    The US Department of Energy`s (DOE) Hanford Site has been placed on the National Priorities List, which requires that it be remediated under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) or Superfund. Potentially contaminated areas of the Hanford Site were grouped into operable units, and detailed characterization and investigation plans were formulated. The DOE Richland Operations Office requested Westinghouse Hanford Company (WHC) to conduct a biological assessment of the potential impact of these characterization activities on the threatened, endangered, and sensitive wildlife species of the Hanford Site. Additional direction for WHC compliances with wildlife protection can be found in the Environmental Compliance Manual. This document is intended to meet these requirements, in part, for the CERCLA characterization activities, as well as for other work comparable in scope. This report documents the biological assessment and describes the pertinent components of the Hanford Site as well as the planned characterization activities. Also provided are accounts of endangered, threatened, and federal candidate wildlife species on the Hanford Site and information as to how human disturbances can affect these species. Potential effects of the characterization activities are described with recommendations for mitigation measures.

  19. Site characterization plan: Yucca Mountain site, Nevada research and development area, Nevada: Consultation draft, Nuclear Waste Policy Act

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-01-01

    Chapter six describes the basis for facility design, the completed facility conceptual design, the completed analytical work relating to the resolution of design issues, and future design-related work. The basis for design and the conceptual design information presented in this chapter meet the requirements of the Nuclear Waste Policy Act of 1982, for a conceptual repository design that takes into account site-specific requirements. This information is presented to permit a critical evaluation of planned site characterization activities. Chapter seven describes waste package components, emplacement environment, design, and status of research and development that support the Nevada Nuclear Waste Storage Investigation (NNWSI) Project. The site characterization plan (SCP) discussion of waste package components is contained entirely within this chapter. The discussion of emplacement environment in this chapter is limited to considerations of the environment that influence, or which may influence, if perturbed, the waste packages and their performance (particularly hydrogeology, geochemistry, and borehole stability). The basis for conceptual waste package design as well as a description of the design is included in this chapter. The complete design will be reported in the advanced conceptual design (ACD) report and is not duplicated in the SCP. 367 refs., 173 figs., 68 tabs.

  20. Examination of CRISPR/Cas9 design tools and the effect of target site accessibility on Cas9 activity.

    Science.gov (United States)

    Lee, Ciaran M; Davis, Timothy H; Bao, Gang

    2017-03-16

    What is the topic of this review? In this review, we analyse the performance of recently described tools for CRISPR/Cas9 guide RNA design, in particular, design tools that predict CRISPR/Cas9 activity. What advances does it highlight? Recently, many tools designed to predict CRISPR/Cas9 activity have been reported. However, the majority of these tools lack experimental validation. Our analyses indicate that these tools have poor predictive power. Our preliminary results suggest that target site accessibility should be considered in order to develop better guide RNA design tools with improved predictive power. The recent adaptation of the clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system for targeted genome engineering has led to its widespread application in many fields worldwide. In order to gain a better understanding of the design rules of CRISPR/Cas9 systems, several groups have carried out large library-based screens leading to some insight into sequence preferences among highly active target sites. To facilitate CRISPR/Cas9 design, these studies have spawned a plethora of guide RNA (gRNA) design tools with algorithms based solely on direct or indirect sequence features. Here, we demonstrate that the predictive power of these tools is poor, suggesting that sequence features alone cannot accurately inform the cutting efficiency of a particular CRISPR/Cas9 gRNA design. Furthermore, we demonstrate that DNA target site accessibility influences the activity of CRISPR/Cas9. With further optimization, we hypothesize that it will be possible to increase the predictive power of gRNA design tools by including both sequence and target site accessibility metrics. © 2017 The Authors. Experimental Physiology © 2017 The Physiological Society.

  1. Characterization of Pu-contaminated soils from Nuclear Site 201 at the Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S.Y.; Tamura, T.; Larsen, I.L.

    1983-01-01

    Distribution and characteristics of Pu-bearing radioactive particles throughout five soil profiles from Nuclear Site (NS) 201 were investigated. Concentrations of /sup 239/ /sup 240/Pu and /sup 241/Am decreased with depth and most of the contamination was contained in the top 5 cm except in profile 4 where it extended to 10 cm. The mean activity ratio of /sup 239/ /sup 240/Pu to /sup 241/Am and its standard error were 5.8 +- 0.3 (N=42). Most of the total radioactivity of the soils was contributed by 0.25 to 2 mm sand size fraction which comprised 20 to 50% by weight of the soils. The radioactive particles in the 0.25 to 2 mm size fraction occurred as spherical glass particles or as glass coatings on sand particles. The glass coatings had gas voids in the matrix but were not as porous as the radioactive particles from NS 219. After impact grinding the >0.25-mm size fractions for one hour, 85% of the initial activity in a NS 201 sample remained with the particles on the 0.25 mm sieve, whereas in the NS 219 sample only 10% remained. The results show that the radioactive particles from NS 201 were much more stable against the impact grinding force than those from NS 219. Therefore, the NS 201 soils would be expected to have a lower probability of producing respirable-size radioactive particles by saltation during wind erosion. 19 references, 3 figures, 3 tables.

  2. Characterization of a Dmd (EGFP) reporter mouse as a tool to investigate dystrophin expression.

    Science.gov (United States)

    Petkova, Mina V; Morales-Gonzales, Susanne; Relizani, Karima; Gill, Esther; Seifert, Franziska; Radke, Josefine; Stenzel, Werner; Garcia, Luis; Amthor, Helge; Schuelke, Markus

    2016-01-01

    Dystrophin is a rod-shaped cytoplasmic protein that provides sarcolemmal stability as a structural link between the cytoskeleton and the extracellular matrix via the dystrophin-associated protein complex (DAPC). Mutations in the dystrophin-encoding DMD gene cause X-linked dystrophinopathies with variable phenotypes, the most severe being Duchenne muscular dystrophy (DMD) characterized by progressive muscle wasting and fibrosis. However, dystrophin deficiency does not only impair the function of skeletal and heart muscle but may also affect other organ systems such as the brain, eye, and gastrointestinal tract. The generation of a dystrophin reporter mouse would facilitate research into dystrophin muscular and extramuscular pathophysiology without the need for immunostaining. We generated a Dmd (EGFP) reporter mouse through the in-frame insertion of the EGFP coding sequence behind the last Dmd exon 79, which is known to be expressed in all major dystrophin isoforms. We analyzed EGFP and dystrophin expression in various tissues and at the single muscle fiber level. Immunostaining of various members of the DAPC was done to confirm the correct subsarcolemmal location of dystrophin-binding partners. We found strong natural EGFP fluorescence at all expected sites of dystrophin expression in the skeletal and smooth muscle, heart, brain, and retina. EGFP fluorescence exactly colocalized with dystrophin immunostaining. In the skeletal muscle, dystrophin and other proteins of the DAPC were expressed at their correct sarcolemmal/subsarcolemmal localization. Skeletal muscle maintained normal tissue architecture, suggesting the correct function of the dystrophin-EGFP fusion protein. EGFP expression could be easily verified in isolated myofibers as well as in satellite cell-derived myotubes. The novel dystrophin reporter mouse provides a valuable tool for direct visualization of dystrophin expression and will allow the study of dystrophin expression in vivo and in vitro in

  3. Report of the Peer Review Panel on the early site suitability evaluation of the Potential Repository Site at Yucca Mountain, Nevada; Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-01-01

    The US Department of Energy (DOE) Yucca mountain Site Characterization Project Office (YMPO) assigned Science Applications International Corporation (SAIC), the Technical and Management Support Services (T&MSS) contractor to the YmPo, the task of conducting an Early Site Suitability Evaluation (ESSE) of the Yucca mountain site as a potential site for a high-level radioactive waste repository. First, the assignment called for the development of a method to evaluate a single site against the DOE General Guidelines for Recommendation of Sites for Nuclear Waste Repositories, 10 CFR Part 960. Then, using this method, an evaluation team, the ESSE Core Team, of senior YMP scientists, engineers, and technical experts, evaluated new information obtained about the site since publication of the final Environmental Assessment (DOE, 1986) to determine if new suitability/unsuitability findings could be recommended. Finally, the Core Team identified further information and analyses needed to make final determinations for each of the guidelines. As part of the task, an independent peer review of the ESSE report has been conducted. Expertise was solicited that covered the entire spectrum of siting guidelines in 10 CFR Part 960 in order to provide a complete, in-depth critical review of the data evaluated and cited in the ESSE report, the methods used to evaluate the data, and the conclusions and recommendations offered by the report. Fourteen nationally recognized technical experts (Table 2) served on the Peer Review Panel. The comments from the Panel and the responses prepared by the ESSE Core Team, documented on formal Comment Response Forms, constitute the body of this document.

  4. Site characterization

    Energy Technology Data Exchange (ETDEWEB)

    Brown, W.S.; Green, S.J.; Hustrulid, W.A. (comps.)

    1976-01-01

    The papers presented at the Conference discussed the topics of modelling and analysis, coal recovery, oil and gas applications, surface structures and slope stability, underground opening design, geothermal energy recovery, in-situ methods, near surface underground opening design, blasting design, rock mechanics, and ground support. Abstracts were prepared for selected papers. (JSR)

  5. Site characterization progress report, Yucca Mountain, Nevada: Number 19, April 1, 1998--September 30, 1998

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-06-01

    The nineteenth semiannual report of the Yucca Mountain Site Characterization Project (YMP) summarizes activities during the period from April 1, 1998, through September 30, 1998. Project activities are aimed at evaluating Yucca Mountain as a potential location for permanent geologic disposal of nuclear materials, as directed by the Nuclear Waste Policy Act of 1982, as amended (NWPA). The progress report documents activities this period that contribute to completing the Project`s near-term programmatic and statutory objectives. These objectives include completing the Viability Assessment, the Environmental Impact Statement (EIS), a possible US Department of Energy (DOE) Secretarial Site Recommendation to the President, and, if the site is suitable, submittal of a license application to the US Nuclear Regulatory Commission (NRC). Project work this period continued to be concentrated in three integrated activities: site characterization, engineering design and construction, and performance assessment. Accomplishments this period and their relation to near-term objectives are briefly summarized.

  6. Combining a Virtual Learning Tool and Onsite Study Visits of Four Conservation Sites in Europe

    Directory of Open Access Journals (Sweden)

    A. Chenaux

    2011-12-01

    Full Text Available The design and evaluation of virtual learning environments for construction and surveying students is presented in this paper; by combining virtual learning environment and on-site student surveys to model and replicate practice in the architectural heritage sector. The Virtual Learning Environment is enhanced with real live survey projects whereby students collect the data to build virtual historic buildings from onsite surveys using advanced survey equipment. The survey data is modelled in HBIM; Historic Building Information Modelling (HBIM is currently being developed as a virtual learning tool for construction and surveying students in the Dublin Institute of Technology.  HBIM, is a novel solution whereby interactive parametric objects representing architectural elements are constructed from historic data, these elements, including detail behind the scan surface are accurately mapped onto a laser or image based survey. The architectural elements are scripted using a Geometric Descriptive Language GDL. In the case of this project a Virtual Learning Environment is being developed which combines advanced recording and surveying with Building Information Modelling (BIM to simulate and analyse existing buildings.

  7. Vetiver Grass: a potential tool for phytoremediation of iron ore mine site spoil dump

    Directory of Open Access Journals (Sweden)

    Anita Mukherjee

    2015-06-01

    Full Text Available The impact of mining has lead to the generation of a large amount of spoil dumps that has become dangerous to human health, wildlife and biodiversity. Thus it is essential that the post mining areas and waste land generated need to be rapidly vegetated. Vetiver grass (Chrysopogon zizanioides (L. Roberty is a tropical plant which grows naturally in various soil conditions and is well known for its ability to resist DNA damage while growing on typically polluted soil conditions. The spoil dumps from the iron mine site is unstable and inhospitable for plant growth due to presence of various toxic heavy metals like - Fe, Mn, Zn, Cu, Pb, Ni, Cr, Cd etc. Vetiver system is an efficient bio-engineering tool for reclaiming such spoil dumps. There are 12 known species of Vetiver grass, and many hundreds of different cultivars that are exploited by users depending on need. In the present study we selected the polyploid infertile variety of vetiver and carried pot experiments. Vetiver plants grown on the iron ore mine spoil dump show distinct differences in their growth with fewer numbers of tillers, reduced chlorophyll content, upregulation of antioxidant enzymes and increased proline content. To investigate the level of DNA damage incurred and change in the genetic stability Comet assay and RAPD analysis were performed. Results confirmed that Vetiver grass can serve as a model species for phytoremediating the iron ore mine spoil dumps.

  8. Site Characterization Work Plan for Gasbuggy, New Mexico (Rev.1, Jan. 2002)

    Energy Technology Data Exchange (ETDEWEB)

    U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office (NNSA/NV)

    2002-01-25

    Project Gasbuggy was the first of three joint government-industry experiments conducted to test the effectiveness of nuclear explosives to fracture deeply buried, low-permeability natural gas reservoirs to stimulate production. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the Project Gasbuggy Site. Its goal is the collection of data in sufficient quantity and quality to determine current site conditions, support a risk assessment for the site surfaces, and evaluate if further remedial action is required to achieve permanent closure of the site that is both protective of human health and the environment. The Gasbuggy Site is located approximately 55 air miles east of Farmington, New Mexico, in Rio Arriba County within the Carson National Forest in the northeast portion of the San Juan Basin. Historically, Project Gasbuggy consisted of the joint government-industry detonation of a nuclear device on December 10, 1967, followed by reentry drilling and gas production testing and project evaluation activities in post-detonation operations from 1967 to 1976. Based on historical documentation, no chemical release sites other than the mud pits were identified; additionally, there was no material buried at the Gasbuggy Site other than drilling fluids and construction debris. Although previous characterization and restoration activities including sensitive species surveys, cultural resources surveys, surface geophysical surveys, and limited soil sampling and analysis were performed in 1978 and again in 2000, no formal closure of the site was achieved. Also, these efforts did not adequately address the site's potential for chemical contamination at the surface/shallow subsurface ground levels or the subsurface hazards for potential migration outside of the current site subsurface intrusion restrictions. Additional investigation

  9. Site characterization progress report: Yucca Mountain, Nevada. October 1, 1996--March 31, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The report is the sixteenth in a series issued approximately every six months to report progress and results of site characterization activities being conducted to evaluate Yucca Mountain as a possible geologic repository for the disposal of spent nuclear fuel and high-level radioactive waste. This report highlights work started, in progress, and completed during the reporting period. In addition, this report documents and discusses changes to the Office of Civilian Radioactive Waste Management (OCRWM) Site Characterization Program (Program) resulting from the ongoing collection and evaluation of site information, systems analyses, development of repository and waste package designs, and results of performance assessment activities. Details on the activities summarized can be found in the numerous technical reports cited throughout the progress report. Yucca Mountain Site Characterization Project (Project) activities this period focused on implementing the near-term objectives of the revised Program Plan issued last period. Near-term objectives of the revised Program Plan include updating the US Department of Energy`s (DOE) repository siting guidelines to be consistent with a more focused performance-driven program; supporting an assessment in 1998 of the viability of continuing with actions leading to the licensing of a repository; and if the site is suitable, submittal of a Secretarial site recommendation to the President in 2001 and license application the US Nuclear Regulatory Commission (NRC) in 2002. During this reporting period, the Project developed and baselined its long-range plan in December 1996. That revision reflected the detailed fiscal year (FY) 1997 work scope and funding plan previously baselined at the end of FY 1996. Site characterization activities have been focused to answer the major open technical issues and to support the viability assessment.

  10. SPATIALLY-EXPLICIT BAT IMPACT SCREENING TOOL FOR WIND TURBINE SITING

    Energy Technology Data Exchange (ETDEWEB)

    Versar, Inc.; Exponent, Inc.

    2013-10-28

    As the U.S. seeks to increase energy production from renewable energy sources, development of wind power resources continues to grow. One of the most important ecological issues restricting wind energy development, especially the siting of wind turbines, is the potential adverse effect on bats. High levels of bat fatality have been recorded at a number of wind energy facilities, especially in the eastern United States. The U.S. Department of Energy contracted with Versar, Inc., and Exponent to develop a spatially-explicit site screening tool to evaluate the mortality of bats resulting from interactions (collisions or barotrauma) with wind turbines. The resulting Bat Vulnerability Assessment Tool (BVAT) presented in this report integrates spatial information about turbine locations, bat habitat features, and bat behavior as it relates to possible interactions with turbines. A model demonstration was conducted that focuses on two bat species, the eastern red bat (Lasiurus borealis) and the Indiana bat (Myotis sodalis). The eastern red bat is a relatively common tree-roosting species that ranges broadly during migration in the Eastern U.S., whereas the Indiana bat is regional species that migrates between a summer range and cave hibernacula. Moreover, Indiana bats are listed as endangered, and so the impacts to this species are of particular interest. The model demonstration used conditions at the Mountaineer Wind Energy Center (MWEC), which consists of 44 wind turbines arranged in a linear array near Thomas, West Virginia (Tucker County), to illustrate model functions and not to represent actual or potential impacts of the facility. The turbines at MWEC are erected on the ridge of Backbone Mountain with a nacelle height of 70 meters and a collision area of 72 meters (blade height) or 4,071 meters square. The habitat surrounding the turbines is an Appalachian mixed mesophytic forest. Model sensitivity runs showed that bat mortality in the model was most sensitive to

  11. Site characterization progress report: Yucca Mountain, Nevada, October 1, 1993--March 31, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-10-01

    This report is the tenth in a series issued at intervals of approximately six months during site characterization of Yucca Mountain as a possible site for a geologic repository for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Also included in this report are descriptions of activities such as public outreach and international programs that are not formally part of the site characterization process. Information on these activities is provided to report on all aspects of the Yucca Mountain studies. The Executive Summary is intended to provide a summary of major decisions, activities, accomplishments, and issues of interest during the reporting period. Chapter 1, Introduction, provides background information to assist the reader in understanding the current status of the program. Chapter 2 provides specific detailed discussions of activities conducted during the current reporting period and has two major divisions. Section 2.1, Preparatory Activities, provides information on select preparatory activities necessary to conduct site characterization and design activities. Sections 2.2 through 2.8 provide specific details on studies and activities conducted during the reporting period and follow the original structure of the Department`s 1988 Site Characterization Plan. Chapter 3 contains the current summary schedule, while Chapter 4 provides a description of the program outreach, including activities during the reporting period, in both the international program and public outreach. Chapter 5 presents an epilogue of significant events that occurred after the end of the reporting period.

  12. Area 5 Site Characterization Project: Report of hydraulic property analysis through August 1993

    Energy Technology Data Exchange (ETDEWEB)

    Estrella, R.; Tyler, S.; Chapman, J.; Miller, M.

    1993-12-01

    The Area 5 Site Characterization Project is designed to determine the suitability of the Radioactive Waste Management Site (RWMS) for disposal of low-level waste (LLW), mixed waste (MW) and transuranic waste (TRU). The Desert Research Institute (DRI) has supported the Area 5 Site Characterization Project for the US Department of Energy, Nevada Operations Office (DOE/NV), Environmental Restoration and Waste Management Division (ERWM), Waste Operations Branch (WOB). The purpose of DRI`s Area 5 Site Characterization project is to characterize important properties of the upper vadose zone which influence infiltration and redistribution of water and transport of solutes as well as to characterize the water quality and hydrologic conditions of the uppermost aquifer. This report describes methods and presents a summary of all data and results from laboratory physical and chemical testing from Pilot Wells and Science Trench borehole samples through August 1993. DRI laboratories performed soil water content, soil water potential, soil bulk density, soil water extract isotope analyses and soil water chemistry analyses.

  13. Geotechnical characterization of the North Ramp of the Exploratory Studies Facility: Yucca Mountain Site Characterization Project. Volume 1, Data summary

    Energy Technology Data Exchange (ETDEWEB)

    Brechtel, C.E.; Lin, Ming; Martin, E. [Agapito Associates, Inc., Grand Junction, CO (United States); Kessel, D.S. [Sandia National Labs., Albuquerque, NM (United States)

    1995-05-01

    This report presents the results of geological and geotechnical characterization of the Miocene volcanic tuff rocks of the Timber Mountain and Paintbrush groups that the tunnel boring machine will encounter during excavation of the Exploratory Studies Facility (ESF) North Ramp. The is being constructed by the DOE as part of the Yucca Mountain Project site characterization activities. The purpose of these activities is to evaluate the feasibility of locating a potential high-level nuclear waste repository on lands adjacent to the Nevada Test Site, Nye County, Nevada. This report was prepared as part of the Soil and Rock Properties Studies in accordance with the 8.3.1.14.2 Study Plan. This report is volume 1 of the data summary.

  14. CO2 Field Laboratory at Svelvik Ridge: Site characterization after the first injection experiment

    Science.gov (United States)

    Buddensiek, M. L.; Lindeberg, E.; Mørk, A.; Jones, D.; Girard, J. F.; Kuras, O.; Barrio, M.; Royse, K.; Gal, F.; Meldrum, P.; Pezard, P.; Levannier, A.; Desroches, J.; Neyens, D.; Paris, J.; Henry, G.; Bakk, A.; Wertz, F.; Aker, E.; Børresen, M.

    2012-04-01

    geochemical logging tools, with GPR, and water samplers. Surface monitoring included stationary and mobile tools for geochemical analyses of ground water, soil and atmospheric gas. Even though the trajectory of migrating CO2 deviated somewhat from the predictions, most stationary monitoring techniques picked up some trace of the CO2 plume. The surfacing CO2 flow was measured most precisely since the mobile surface stations were (re-)located over the leakage areas. After the injection test, numerous sediment samples were taken at various depths and locations around the injection point. Together with the monitoring results, these data are used to better characterize the site and to update the geological and flow model for improved interpretation of the experiments. The results show that accurate information on the stratigraphic variability is of outmost importance for understanding possible pathways of CO2 in the shallow subsurface.

  15. Three-Dimensional High-Frequency Ultrasonography for Early Detection and Characterization of Embryo Implantation Site Development in the Mouse.

    Directory of Open Access Journals (Sweden)

    Mary C Peavey

    Full Text Available Ultrasonography is a powerful tool to non-invasively monitor in real time the development of the human fetus in utero. Although genetically engineered mice have served as valuable in vivo models to study both embryo implantation and pregnancy progression, such studies usually require sacrifice of parous mice for subsequent phenotypic analysis. To address this issue, we used three-dimensional (3-D reconstruction in silico of high-frequency ultrasound (HFUS imaging data for early detection and characterization of murine embryo implantation sites and their development in utero. With HFUS imaging followed by 3-D reconstruction, we were able to precisely quantify embryo implantation site number and embryonic developmental progression in pregnant C57BL6J/129S mice from as early as 5.5 days post coitus (d.p.c. through to 9.5 d.p.c. using a VisualSonics Vevo 2100 (MS550S transducer. In addition to measurements of implantation site number, location, volume and spacing, embryo viability via cardiac activity monitoring was also achieved. A total of 12 dams were imaged with HFUS with approximately 100 embryos examined per embryonic day. For the post-implantation period (5.5 to 8.5 d.p.c., 3-D reconstruction of the gravid uterus in mesh or solid overlay format enabled visual representation in silico of implantation site location, number, spacing distances, and site volume within each uterine horn. Therefore, this short technical report describes the feasibility of using 3-D HFUS imaging for early detection and analysis of post-implantation events in the pregnant mouse with the ability to longitudinally monitor the development of these early pregnancy events in a non-invasive manner. As genetically engineered mice continue to be used to characterize female reproductive phenotypes, we believe this reliable and non-invasive method to detect, quantify, and characterize early implantation events will prove to be an invaluable investigative tool for the study of

  16. Geological characterization of contaminated sites near the city of Horsens, Denmark

    DEFF Research Database (Denmark)

    Andersen, Theis Raaschou; Poulsen, Søren Erbs; Thomsen, Peter

    Keywords: geological modelling, urban area, contaminant transport In Denmark, contaminations from industry, farming and households represent a significant threat to groundwater resources since water treatment in Denmark relies solely on two simple steps: 1) oxygenation of the source water and 2) ...... were able to pinpoint the best strategies and solutions for future remediation efforts at the three sites.......) filtration by means of water saturated, rapid biofilters. Consequently, there is a focus on identifying and locating contaminated sites on a national level. Insufficient knowledge about the geology and hydrology at the sites poses a significant challenge for remediation efforts. The lack of information about...... characterization of three contaminated sites situated in urban and semi-urban areas around the city of Horsens in corporation with authorities. The existing data from the three field sites include lithological profiles from boreholes. In order to increase the data density, Electrical Resistivity Tomography (ERT...

  17. Using complementary tools to characterize the effects of radiation in electro-optic polymeric materials

    Science.gov (United States)

    Perez-Moreno, Javier

    2015-09-01

    Understanding the fundamental mechanisms behind the radiation resistance of polymers and molecules would allow us to tailor new materials with enhanced performance in space and adverse environments. Previous studies of the radiation effects on polymer-based photonic materials indicate that they are very dependent on the choice of polymer-host and guest-chromophores. The best results have been reported from the combination of CLD1 as a guest-chromophore doped in APC as host polymer, where improvement of the performance was observed upon gamma-irradiation at moderate doses. In this paper, we report on the different complementary tools that have been tried to characterize the origin of such enhancement: characterization of the linear and nonlinear response, characterization of chemical properties, and application of an all-optical protocol. We derive some general conclusions by contrasting the results of each characterization, and propose complementary experiments based on microscopy techniques.

  18. COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

    Directory of Open Access Journals (Sweden)

    Thomas J Cradick

    2014-01-01

    Full Text Available Precise genome editing using engineered nucleases can significantly facilitate biological studies and disease treatment. In particular, clustered regularly interspaced short palindromic repeats (CRISPR with CRISPR-associated (Cas proteins are a potentially powerful tool for modifying a genome by targeted cleavage of DNA sequences complementary to designed guide strand RNAs. Although CRISPR/Cas systems can have on-target cleavage rates close to the transfection rates, they may also have relatively high off-target cleavage at similar genomic sites that contain one or more base pair mismatches, and insertions or deletions relative to the guide strand. We have developed a bioinformatics-based tool, COSMID (CRISPR Off-target Sites with Mismatches, Insertions, and Deletions that searches genomes for potential off-target sites (http://crispr.bme.gatech.edu. Based on the user-supplied guide strand and input parameters, COSMID identifies potential off-target sites with the specified number of mismatched bases and insertions or deletions when compared with the guide strand. For each site, amplification primers optimal for the chosen application are also given as output. This ranked-list of potential off-target sites assists the choice and evaluation of intended target sites, thus helping the design of CRISPR/Cas systems with minimal off-target effects, as well as the identification and quantification of CRISPR/Cas induced off-target cleavage in cells.

  19. Los Alamos National Laboratory Yucca Mountain Site Characterization Project 1995 quality program status report

    Energy Technology Data Exchange (ETDEWEB)

    Bolivar, S.L.

    1996-07-01

    This status report summarizes the activities and accomplishments of the Los Alamos National Laboratory Yucca Mountain Site Characterization Project`s (YMP`s) quality assurance program for January 1 to September 30, 1995. The report includes major sections on program activities and trend analysis.

  20. Distance learning and its application to the Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, J.; Sizemore, J. [SAIC, Las Vegas, NV (United States)

    1995-12-01

    This paper discusses the concept of distance learning, which is used to exchange information via electronic media with real time interaction. Issues concerning policy, funding, legislation, accessibility, and programming are outlined. Possible applications for education, business, and federal projects, with a focus on the Yucca Mountain Site Characterization Project, are also discussed.

  1. Modelling tools for integrating geological, geophysical and contamination data for characterization of groundwater plumes

    DEFF Research Database (Denmark)

    Balbarini, Nicola

    on borehole investigations to collect the geological, hydrological, and contaminant data. These data are integrated in conceptual and mathematical models describing the lithology, the groundwater flow, and the distribution of contaminant concentrations. Models are needed to analyze the potential risks to all...... in modelling tools used for investigations of contaminated sites. This thesis presents the development of modelling tools to integrate DCIP methods with geological, hydrological and contaminant concentration data. The developed tools describe groundwater flow to meandering streams, map the distribution...... factors, including stream channel geometry. In this study, numerical models simulating groundwater flow to synthetic sinuous streams and to a real meandering stream were developed. Comparison of the models showed that groundwater discharge to streams is greatly affected by the geometry of meanders...

  2. An Optimized Calcium-Phosphate Transfection Method for Characterizing Genetically Encoded Tools in Primary Neurons.

    Science.gov (United States)

    Wang, Shiyao; Cho, Yong Ku

    2016-01-01

    In order to characterize genetically encoded tools under the most relevant conditions, the constructs need to be expressed in the cell type in which they will be used. This is a major hurdle in developing optogenetic tools for neuronal cells, due to the difficulty of gene transfer to these cells. Several protocols have been developed for transfecting neurons, focusing on improved transfection efficiency. However, obtaining healthy cells is as important. We monitored transfected cell health by measuring electrophysiological parameters, and used them as a guideline to optimize transfection. Here we describe an optimized transfection protocol that achieves reasonably high efficiency (10-20 %) with no discernable impact on cell health, as characterized by electrophysiology.

  3. Seismic Hazard Characterization at the DOE Savannah River Site (SRS): Status report

    Energy Technology Data Exchange (ETDEWEB)

    Savy, J.B.

    1994-06-24

    The purpose of the Seismic Hazard Characterization project for the Savannah River Site (SRS-SHC) is to develop estimates of the seismic hazard for several locations within the SRS. Given the differences in the geology and geotechnical characteristics at each location, the estimates of the seismic hazard are to allow for the specific local conditions at each site. Characterization of seismic hazard is a critical factor for the design of new facilities as well as for the review and potential retrofit of existing facilities at SRS. The scope of the SRS seismic hazard characterization reported in this document is limited to the Probabilistic Seismic Hazard Analysis (PSHA). The goal of the project is to provide seismic hazard estimates based on a state-of-the-art method which is consistent with developments and findings of several ongoing studies which are deemed to bring improvements in the state of the seismic hazard analyses.

  4. Strategic Petroleum Reserve (SPR) geological site characterization report, Big Hill Salt Dome

    Energy Technology Data Exchange (ETDEWEB)

    Hart, R.J.; Ortiz, T.S.; Magorian, T.R.

    1981-09-01

    Geological and geophysical analyses of the Big Hill Salt Dome were performed to determine the suitability of this site for use in the Strategic Petroleum Reserve (SPR). Development of 140 million barrels (MMB) of storage capacity in the Big Hill Salt Dome is planned as part of the SPR expansion to achieve 750 MMB of storage capacity. Objectives of the study were to: (1) Acquire, evaluate, and interpret existing data pertinent to geological characterization of the Big Hill Dome; (2) Characterize the surface and near-surface geology and hydrology; (3) Characterize the geology and hydrology of the overlying cap rock; (4) Define the geometry and geology of the dome; (5) Determine the feasibility of locating and constructing 14 10-MMB storage caverns in the south portion of the dome; and (6) Assess the effects of natural hazards on the SPR site. Recommendations are included. (DMC)

  5. Report on expedited site characterization of the Central Nevada Test Area, Nye County, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Yuhr, L. [Technos Inc., Miami, FL (United States); Wonder, J.D.; Bevolo, A.J. [Ames Lab., IA (United States)

    1997-09-01

    This report documents data collection, results, and interpretation of the expedited site characterization (ESC) pilot project conducted from September 1996 to June 1997 at the Central Nevada Test Area (CNTA), Nye County, Nevada. Characterization activities were limited to surface sites associated with deep well drilling and ancillary operations at or near three emplacement well areas. Environmental issues related to the underground nuclear detonation (Project Faultless) and hydrologic monitoring wells were not addressed as a part of this project. The CNTA was divided into four functional areas for the purpose of this investigation and report. These areas include the vicinity of three emplacement wells (UC-1, UC-3, and UC-4) and one mud waste drilling mud collection location (Central Mud Pit; CMP). Each of these areas contain multiple, potentially contaminated features, identified either from historic information, on-site inspections, or existing data. These individual features are referred to hereafter as ``sites.`` The project scope of work involved site reconnaissance, establishment of local grid systems, site mapping and surveying, geophysical measurements, and collection and chemical analysis of soil and drilling mud samples. Section 2.0 through Section 4.0 of this report provide essential background information about the site, project, and details of how the ESC method was applied at CNTA. Detailed discussion of the scope of work is provided in Section 5.0, including procedures used and locations and quantities of measurements obtained. Results and interpretations for each of the four functional areas are discussed separately in Sections 6.0, 7.0, 8.0, and 9.0. These sections provide a chronological presentation of data collected and results obtained, followed by interpretation on a site-by-site basis. Key data is presented in the individual sections. The comprehensive set of data is contained in appendices.

  6. Assessing an Infant Feeding Web Site as a Nutrition Education Tool for Child Care Providers

    Science.gov (United States)

    Clark, Alena; Anderson, Jennifer; Adams, Elizabeth; Baker, Susan; Barrett, Karen

    2009-01-01

    Objective: Determine child care providers' infant feeding knowledge, attitude and behavior changes after viewing the infant feeding Web site and determine the effectiveness of the Web site and bilingual educational materials. Design: Intervention and control groups completed an on-line pretest survey, viewed a Web site for 3 months, and completed…

  7. Conversion of the Bayou Choctaw geological site characterization report to a three-dimensional model.

    Energy Technology Data Exchange (ETDEWEB)

    Stein, Joshua S. (Sandia National Laboratories, Carlsbad, NM); Rautman, Christopher Arthur

    2004-02-01

    The geologic model implicit in the original site characterization report for the Bayou Choctaw Strategic Petroleum Reserve Site near Baton Rouge, Louisiana, has been converted to a numerical, computer-based three-dimensional model. The original site characterization model was successfully converted with minimal modifications and use of new information. The geometries of the salt diapir, selected adjacent sedimentary horizons, and a number of faults have been modeled. Models of a partial set of the several storage caverns that have been solution-mined within the salt mass are also included. Collectively, the converted model appears to be a relatively realistic representation of the geology of the Bayou Choctaw site as known from existing data. A small number of geometric inconsistencies and other problems inherent in 2-D vs. 3-D modeling have been noted. Most of the major inconsistencies involve faults inferred from drill hole data only. Modem computer software allows visualization of the resulting site model and its component submodels with a degree of detail and flexibility that was not possible with conventional, two-dimensional and paper-based geologic maps and cross sections. The enhanced visualizations may be of particular value in conveying geologic concepts involved in the Bayou Choctaw Strategic Petroleum Reserve site to a lay audience. A Microsoft WindowsTM PC-based viewer and user-manipulable model files illustrating selected features of the converted model are included in this report.

  8. Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior

    DEFF Research Database (Denmark)

    Hirschberg, Cosima; Boetker, Johan P; Rantanen, Jukka

    2018-01-01

    be monitored with an in-line near-infrared (NIR) spectrometer. Calculating the root mean square (RMS) of the scores of the two first principal components of the NIR spectra visualized spectral variation as a function of process time. In a same setup, mechanical properties (basic flow energy) of the powder......There is an increasing need to provide more detailed insight into the behavior of particulate systems. The current powder characterization tools are developed empirically and in many cases, modification of existing equipment is difficult. More flexible tools are needed to provide understanding...... of complex powder behavior, such as mixing process and segregation phenomenon. An approach based on the fast prototyping of new powder handling geometries and interfacing solutions for process analytical tools is reported. This study utilized 3D printing for rapid prototyping of customized geometries...

  9. Modelling tools for integrating geological, geophysical and contamination data for characterization of groundwater plumes

    DEFF Research Database (Denmark)

    Balbarini, Nicola

    Contaminated sites are a major issue threatening the environment and the human health. The large number of contaminated sites require cost effective investigations to perform risk assessment and prioritize the sites that need remediation. Contaminated soil and groundwater investigations rely...... on borehole investigations to collect the geological, hydrological, and contaminant data. These data are integrated in conceptual and mathematical models describing the lithology, the groundwater flow, and the distribution of contaminant concentrations. Models are needed to analyze the potential risks to all...... receptors, including streams. Key risk assessment parameters, such as contaminant mass discharge estimates, and tools are then used to evaluate the risk. The cost of drilling often makes investigations of large and/or deep contaminant plumes unfeasible. For this reason, it is important to develop cost...

  10. Site Characterization Data from the U3ax/bl Exploratory Boreholes at the Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Bechtel Nevada; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2005-08-01

    This report provides qualitative analyses and preliminary interpretations of hydrogeologic data obtained from two 45-degree, slanted exploratory boreholes drilled within the Area 3 Radioactive Waste Management Site (RWMS) at the Nevada Test Site. Borehole UE-3bl-D1 was drilled beneath the U3ax/bl mixed waste disposal unit, and Borehole UE-3bl-U1 was drilled in undisturbed alluvium adjacent to the disposal unit. The U3ax/bl disposal unit is located within two conjoined subsidence craters, U3ax and U3bl, which were created by underground nuclear testing. Data from these boreholes were collected to support site characterization activities for the U3ax/bl disposal unit and the entire Area 3 RWMS. Site characterization at disposal units within the Area 3 RWMS must address the possibility that subsidence craters and associated disturbed alluvium of the chimneys beneath the craters might serve as pathways for contaminant migration. The two boreholes were drilled and sampled to compare hydrogeologic properties of alluvium below the waste disposal unit with those of adjacent undisturbed alluvium. Whether Borehole UE-3bl-D1 actually penetrated the chimney of the U3bl crater is uncertain. Analyses of core samples showed little difference in hydrogeologic properties between the two boreholes. Important findings of this study include the following: No hazardous or radioactive constituents of waste disposal concern were found in the samples obtained from either borehole. No significant differences in physical and hydrogeologic properties between boreholes is evident, and no evidence of significant trends with depth for any of these properties was observed. The values observed are typical of sandy materials. The alluvium is dry, with volumetric water content ranging from 5.6 to 16.2 percent. Both boreholes exhibit a slight increase in water content with depth, the only such trend observed. Water potential measurements on core samples from both boreholes show a large positive

  11. Development of the SAFE Checklist Tool for Assessing Site-Level Threats to Child Protection: Use of Delphi Methods and Application to Two Sites in India.

    Directory of Open Access Journals (Sweden)

    Theresa S Betancourt

    Full Text Available The child protection community is increasingly focused on developing tools to assess threats to child protection and the basic security needs and rights of children and families living in adverse circumstances. Although tremendous advances have been made to improve measurement of individual child health status or household functioning for use in low-resource settings, little attention has been paid to a more diverse array of settings in which many children in adversity spend time and how context contributes to threats to child protection. The SAFE model posits that insecurity in any of the following fundamental domains threatens security in the others: Safety/freedom from harm; Access to basic physiological needs and healthcare; Family and connection to others; Education and economic security. Site-level tools are needed in order to monitor the conditions that can dramatically undermine or support healthy child growth, development and emotional and behavioral health. From refugee camps and orphanages to schools and housing complexes, site-level threats exist that are not well captured by commonly used measures of child health and well-being or assessments of single households (e.g., SDQ, HOME.The present study presents a methodology and the development of a scale for assessing site-level child protection threats in various settings of adversity. A modified Delphi panel process was enhanced with two stages of expert review in core content areas as well as review by experts in instrument development, and field pilot testing.Field testing in two diverse sites in India-a construction site and a railway station-revealed that the resulting SAFE instrument was sensitive to the differences between the sites from the standpoint of core child protection issues.

  12. Interim site characterization report and ground-water monitoring program for the Hanford site solid waste landfill

    Energy Technology Data Exchange (ETDEWEB)

    Fruland, R.M.; Hagan, R.A.; Cline, C.S.; Bates, D.J.; Evans, J.C.; Aaberg, R.L.

    1989-07-01

    Federal and state regulations governing the operation of landfills require utilization of ground-water monitoring systems to determine whether or not landfill operations impact ground water at the point of compliance (ground water beneath the perimeter of the facility). A detection-level ground-water monitoring system was designed, installed, and initiated at the Hanford Site Solid Waste Landfill (SWL). Chlorinated hydrocarbons were detected at the beginning of the ground-water monitoring program and continue to be detected more than 1 year later. The most probable source of the chlorinated hydrocarbons is washwater discharged to the SWL between 1985 and 1987. This is an interim report and includes data from the characterization work that was performed during well installation in 1987, such as field observations, sediment studies, and geophysical logging results, and data from analyses of ground-water samples collected in 1987 and 1988, such as field parameter measurements and chemical analyses. 38 refs., 27 figs., 8 tabs.

  13. Engineered materials characterization report for the Yucca Mountain Site Characterization Project. Volume 2, Design data

    Energy Technology Data Exchange (ETDEWEB)

    Konynenburg, R.A.; McCright, R.D. [Lawrence Livermore National Lab., CA (United States); Roy, A.K. [B and W Fuel Co., Lynchburg, VA (United States); Jones, D.A. [Nevada Univ., Reno, NV (United States)

    1995-08-01

    This is Volume 2 of the Engineered Materials Characterization Report which presents the design data for candidate materials needed in fabricating different components for both large and medium multi-purpose canister (MPC) disposal containers, waste packages for containing uncanistered spent fuel (UCF), and defense high-level waste (HLW) glass disposal containers. The UCF waste package consists of a disposal container with a basket therein. It is assumed that the waste packages will incorporate all-metallic multibarrier disposal containers to accommodate medium and large MPCs, ULCF, and HLW glass canisters. Unless otherwise specified, the disposal container designs incorporate an outer corrosion-allowance metal barrier over an inner corrosion-resistant metal barrier. The corrosion-allowance barrier, which will be thicker than the inner corrosion-resistant barrier, is designed to undergo corrosion-induced degradation at a very low rate, thus providing the inner barrier protection from the near-field environment for a prolonged service period.

  14. Geological characterization and solute transport model investigations of contaminated sites in urban areas (Denmark)

    DEFF Research Database (Denmark)

    Andersen, Theis Raaschou; Poulsen, Søren Erbs; Thomsen, Peter

    In Denmark, contaminations from industry and farming represent a significant threat to groundwater resources. On a national level, there is a focus on identifying and locating these contaminated sites. Once located, contaminations are mapped and monitored and remediation efforts are undertaken. R...... the uncertainties of projections on the fate of the contaminant. Based on the work, we were able to pinpoint the best strategies and solutions for future remediation efforts at the two sites.......In Denmark, contaminations from industry and farming represent a significant threat to groundwater resources. On a national level, there is a focus on identifying and locating these contaminated sites. Once located, contaminations are mapped and monitored and remediation efforts are undertaken...... efforts are often challenged by logistics. The general lack of knowledge about theses contaminations introduces significant uncertainties in the projections on the fate of the contaminant. We carry out a geological characterization of two contaminated sites situated in urban areas. The existing data from...

  15. Characterization and design of the FutureGen 2.0 carbon storage site

    Energy Technology Data Exchange (ETDEWEB)

    Gilmore, Tyler; Bonneville, Alain; Sullivan, Charlotte; Kelley, Mark; Appriou, Delphine; Vermeul, Vince; White, Signe; Zhang, Fred; Bjornstad, Bruce; Cornet, Francois; Gerst, Jacqueline; Gupta, Neeraj; Hund, Gretchen; Horner, Jake; Last, George; Lanigan, Dave; Oostrom, Mart; McNeil, Caitlin; Moody, Mark; Rockhold, Mark; Elliott, Mike; Spane, Frank; Strickland, Chris; Swartz, Lucy; Thorne, Paul; Brown, Christopher; Hoffmann, Jeffrey; Humphreys, Kenneth

    2016-10-01

    The objective of the FutureGen 2.0 Project was to demonstrate, at the commercial scale, the technical feasibility of implementing carbon capture and storage (CCS) in a deep saline formation in Illinois, USA. Over approximately 5 years, the FutureGen Alliance conducted a detailed site-selection process and identified a site for carbon sequestration storage in Morgan County, Illinois. The storage site was fully characterized, including the collection of seismic data and the drilling and characterization of a stratigraphic borehole. The characterization data provided critical input for developing a site-specific conceptual model and subsequent numerical modeling simulations. The modeling simulations, coupled with the upstream designs of the pipeline and power plant supported the development of a detailed 90 percent design that included the injection wells and associated control and monitoring infrastructure. Collectively, all these data were used by the FutureGen Alliance to develop the required documentation to support the applications for four underground injection control (UIC) permits (one for each proposed well). In August 2014, the U.S. Environmental Protection Agency issued four, first-of-their-kind, Class VI UIC permits for carbon sequestration in the United States to the FutureGen Alliance. The information and data generated under this project have been made publically available through reports and publications, including this journal and others.

  16. CRISPR/Cas9-loxP-Mediated Gene Editing as a Novel Site-Specific Genetic Manipulation Tool.

    Science.gov (United States)

    Yang, Fayu; Liu, Changbao; Chen, Ding; Tu, Mengjun; Xie, Haihua; Sun, Huihui; Ge, Xianglian; Tang, Lianchao; Li, Jin; Zheng, Jiayong; Song, Zongming; Qu, Jia; Gu, Feng

    2017-06-16

    Cre-loxP, as one of the site-specific genetic manipulation tools, offers a method to study the spatial and temporal regulation of gene expression/inactivation in order to decipher gene function. CRISPR/Cas9-mediated targeted genome engineering technologies are sparking a new revolution in biological research. Whether the traditional site-specific genetic manipulation tool and CRISPR/Cas9 could be combined to create a novel genetic tool for highly specific gene editing is not clear. Here, we successfully generated a CRISPR/Cas9-loxP system to perform gene editing in human cells, providing the proof of principle that these two technologies can be used together for the first time. We also showed that distinct non-homologous end-joining (NHEJ) patterns from CRISPR/Cas9-mediated gene editing of the targeting sequence locates at the level of plasmids (episomal) and chromosomes. Specially, the CRISPR/Cas9-mediated NHEJ pattern in the nuclear genome favors deletions (64%-68% at the human AAVS1 locus versus 4%-28% plasmid DNA). CRISPR/Cas9-loxP, a novel site-specific genetic manipulation tool, offers a platform for the dissection of gene function and molecular insights into DNA-repair pathways. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  17. Web-Site as an Educational Tool in Biology Education: A Case of Nutrition Issue

    Science.gov (United States)

    Fancovicova, Jana; Prokop, Pavol; Usak, Muhammet

    2010-01-01

    The purpose of the study was to evaluate the efficacy and feasibility of using website in biology education. We have explored the World Wide Web as a possible tool for education about health and nutrition. The websites were teaching tools for primary school students. Control groups used the traditional educational materials as books or worksheets,…

  18. Development of a Model Protein Interaction Pair as a Benchmarking Tool for the Quantitative Analysis of 2-Site Protein-Protein Interactions.

    Science.gov (United States)

    Yamniuk, Aaron P; Newitt, John A; Doyle, Michael L; Arisaka, Fumio; Giannetti, Anthony M; Hensley, Preston; Myszka, David G; Schwarz, Fred P; Thomson, James A; Eisenstein, Edward

    2015-12-01

    A significant challenge in the molecular interaction field is to accurately determine the stoichiometry and stepwise binding affinity constants for macromolecules having >1 binding site. The mission of the Molecular Interactions Research Group (MIRG) of the Association of Biomolecular Resource Facilities (ABRF) is to show how biophysical technologies are used to quantitatively characterize molecular interactions, and to educate the ABRF members and scientific community on the utility and limitations of core technologies [such as biosensor, microcalorimetry, or analytic ultracentrifugation (AUC)]. In the present work, the MIRG has developed a robust model protein interaction pair consisting of a bivalent variant of the Bacillus amyloliquefaciens extracellular RNase barnase and a variant of its natural monovalent intracellular inhibitor protein barstar. It is demonstrated that this system can serve as a benchmarking tool for the quantitative analysis of 2-site protein-protein interactions. The protein interaction pair enables determination of precise binding constants for the barstar protein binding to 2 distinct sites on the bivalent barnase binding partner (termed binase), where the 2 binding sites were engineered to possess affinities that differed by 2 orders of magnitude. Multiple MIRG laboratories characterized the interaction using isothermal titration calorimetry (ITC), AUC, and surface plasmon resonance (SPR) methods to evaluate the feasibility of the system as a benchmarking model. Although general agreement was seen for the binding constants measured using solution-based ITC and AUC approaches, weaker affinity was seen for surface-based method SPR, with protein immobilization likely affecting affinity. An analysis of the results from multiple MIRG laboratories suggests that the bivalent barnase-barstar system is a suitable model for benchmarking new approaches for the quantitative characterization of complex biomolecular interactions.

  19. Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site

    OpenAIRE

    Huang, Lin-Ya; Patel, Ami; Ng, Robert; Miller, Edward Blake; Halder, Sujata; McKenna, Robert; Asokan, Aravind; Agbandje-McKenna, Mavis

    2016-01-01

    The adeno-associated viruses (AAVs), which are being developed as gene delivery vectors, display differential cell surface glycan binding and subsequent tissue tropisms. For AAV serotype 1 (AAV1), the first viral vector approved as a gene therapy treatment, and its closely related AAV6, sialic acid (SIA) serves as their primary cellular surface receptor. Toward characterizing the SIA binding site(s), the structure of the AAV1-SIA complex was determined by X-ray crystallography to 3.0 Å. Densi...

  20. A risk assessment tool for contaminated sites in low-permeability fractured media

    DEFF Research Database (Denmark)

    In Denmark, many contaminated sites are located in areas with low permeability or fractured geologies such as glacial moraine clays. Fractures increase the risk of fast transport of contaminants to underlying groundwater systems. It is therefore important to consider fracture transport when...... evaluating the risk of contaminated sites to drinking water resources....

  1. Scenario evaluation of municipal web sites: development and use of an expert-focused evaluation tool

    NARCIS (Netherlands)

    de Jong, Menno D.T.; Lentz, Leo

    2006-01-01

    Municipal Web sites are a prominent product of e-government initiatives worldwide. The Internet is becoming increasingly important in the communication between local governments and citizens, which makes the usability of municipal Web sites a critical factor in government–citizen communication. A

  2. Design and characterization of molecular tools for a Synthetic Biology approach towards developing cyanobacterial biotechnology.

    Science.gov (United States)

    Huang, Hsin-Ho; Camsund, Daniel; Lindblad, Peter; Heidorn, Thorsten

    2010-05-01

    Cyanobacteria are suitable for sustainable, solar-powered biotechnological applications. Synthetic biology connects biology with computational design and an engineering perspective, but requires efficient tools and information about the function of biological parts and systems. To enable the development of cyanobacterial Synthetic Biology, several molecular tools were developed and characterized: (i) a broad-host-range BioBrick shuttle vector, pPMQAK1, was constructed and confirmed to replicate in Escherichia coli and three different cyanobacterial strains. (ii) The fluorescent proteins Cerulean, GFPmut3B and EYFP have been demonstrated to work as reporter proteins in cyanobacteria, in spite of the strong background of photosynthetic pigments. (iii) Several promoters, like P(rnpB) and variants of P(rbcL), and a version of the promoter P(trc) with two operators for enhanced repression, were developed and characterized in Synechocystis sp. strain PCC6803. (iv) It was shown that a system for targeted protein degradation, which is needed to enable dynamic expression studies, is working in Synechocystis sp. strain PCC6803. The pPMQAK1 shuttle vector allows the use of the growing numbers of BioBrick parts in many prokaryotes, and the other tools herein implemented facilitate the development of new parts and systems in cyanobacteria.

  3. Predicted rarity-weighted richness, a new tool to prioritize sites for species representation.

    Science.gov (United States)

    Albuquerque, Fábio; Beier, Paul

    2016-11-01

    Lack of biodiversity data is a major impediment to prioritizing sites for species representation. Because comprehensive species data are not available in any planning area, planners often use surrogates (such as vegetation communities, or mapped occurrences of a well-inventoried taxon) to prioritize sites. We propose and demonstrate the effectiveness of predicted rarity-weighted richness (PRWR) as a surrogate in situations where species inventories may be available for a portion of the planning area. Use of PRWR as a surrogate involves several steps. First, rarity-weighted richness (RWR) is calculated from species inventories for a q% subset of sites. Then random forest models are used to model RWR as a function of freely available environmental variables for that q% subset. This function is then used to calculate PRWR for all sites (including those for which no species inventories are available), and PRWR is used to prioritize all sites. We tested PRWR on plant and bird datasets, using the species accumulation index to measure efficiency of PRWR. Sites with the highest PRWR represented species with median efficiency of 56% (range 32%-77% across six datasets) when q = 20%, and with median efficiency of 39% (range 20%-63%) when q = 10%. An efficiency of 56% means that selecting sites in order of PRWR rank was 56% as effective as having full knowledge of species distributions in PRWR's ability to improve on the number of species represented in the same number of randomly selected sites. Our results suggest that PRWR may be able to help prioritize sites to represent species if a planner has species inventories for 10%-20% of the sites in the planning area.

  4. Yucca Mountain Site Characterization Project bibliography, January--June 1995. Supplement 4, Add.3: An update

    Energy Technology Data Exchange (ETDEWEB)

    Stephan, P.M. [ed.

    1996-01-01

    Following a reorganization of the Office of Civilian Radioactive Waste Management in 1990, the Yucca Mountain Project was renamed Yucca Mountain Site Characterization Project. The title of this bibliography was also changed to Yucca Mountain Site Characterization Project Bibliography. Prior to August 5, 1988, this project was called the Nevada Nuclear Waste Storage Investigations. This bibliography contains information on this ongoing project that was added to the Department of Energy`s Energy Science and Technology Database from January 1, 1995, through June 30, 1995. The bibliography is categorized by principal project participating organization. Participant-sponsored subcontractor reports, papers, and articles are included in the sponsoring organization`s list. Another section contains information about publications on the Energy Science and Technology Database that were not sponsored by the project but have some relevance to it.

  5. Yucca Mountain Site Characterization Project Bibliography, January--June 1993. An update: Supplement 4, Addendum 1

    Energy Technology Data Exchange (ETDEWEB)

    Stephan, P.M. [ed.

    1995-01-01

    Following a reorganization of the Office of Civilian Radioactive Waste Management in 1990, the Yucca Mountain Project was renamed Yucca Mountain Site Characterization Project. The title of this bibliography was also changed to Yucca Mountain Site Characterization Project Bibliography. Prior to August 5, 1988, this project was called the Nevada Nuclear Waste Storage Investigations. This bibliography contains information on this ongoing project that was added to the Department of Energy`s Energy Science and Technology Database from January 1, 1994 through June 30, 1994. The bibliography is categorized by principal project participating organization. Participant-sponsored subcontractor reports, papers,and articles are included in the sponsoring organization`s list. Another section contains information about publications on the Energy Science and Technology Database that were not sponsored by the project but have some relevance to it.

  6. New and improved method of investigation using thermal tools for characterization of cellulose from eucalypts pulp

    Energy Technology Data Exchange (ETDEWEB)

    Lengowski, Elaine Cristina, E-mail: elainelengowski@yahoo.com.br [Laboratório de Anatomia e Qualidade da Madeira – LANAQM, Departamento de Engenharia e Tecnologia Florestal – DETF/Universidade Federal do Paraná, (UFPR), Curitiba, PR (Brazil); Magalhães, Washington Luiz Esteves, E-mail: washington.magalhaes@embrapa.br [Embrapa Florestas, Estrada da Ribeira km 111 P.O. Box 319, 83411-000 Colombo, PR (Brazil); Programa de Pós Graduação em Engenharia de Materiais – PIPE Universidade Federal do Paraná, (UFPR), Curitiba, PR (Brazil); Nisgoski, Silvana, E-mail: silnis@yahoo.com [Laboratório de Anatomia e Qualidade da Madeira – LANAQM, Departamento de Engenharia e Tecnologia Florestal – DETF/Universidade Federal do Paraná, (UFPR), Curitiba, PR (Brazil); Muniz, Graciela Inês Bolzon de, E-mail: graciela.ufpr@gmail.com [Laboratório de Anatomia e Qualidade da Madeira – LANAQM, Departamento de Engenharia e Tecnologia Florestal – DETF/Universidade Federal do Paraná, (UFPR), Curitiba, PR (Brazil); Satyanarayana, Kestur Gundappa [Embrapa Florestas, Estrada da Ribeira km 111 P.O. Box 319, 83411-000 Colombo, PR (Brazil); Lazzarotto, Marcelo, E-mail: marcelo.lazzarotto@embrapa.br [Embrapa Florestas, Estrada da Ribeira km 111 P.O. Box 319, 83411-000 Colombo, PR (Brazil)

    2016-08-20

    Highlights: • Cellulose was treated to modify its crystallinity. • Cellulose was characterized by X-ray diffraction to evaluate Segal’s index. • TGA and DTA with chemometric tools were used to predict Segal’s index. • MLR model was applied to predict XRD cellulose Segal’s index from TGA curves. • MLR model was applied to predict XRD cellulose Segal’s index from DTA curves. - Abstract: Despite cellulose being the most abundant biopolymer on earth and an important commodity, there is a lack of deeper knowledge about its structure as well as faster and more efficient characterization techniques. This paper presents preparation of nanocellulose from bleached cellulose pulp of Eucalyptus by chemical and mechanical pre-treatments, while the cellulose was given treatment to obtain a great range of crystallinity index. The nanocellulose is characterized by X-ray diffraction to evaluate Segal’s index while chemometric tools by TGA and DTA were used to predict Segal’s index. DTA curves, along with multivariate statistical model, presented better result than TGA. The coefficient of variation and standard error of prediction for the proposed models using external validation samples were in the range of 0.91–0.96 and 4.18–8.71, respectively. These successful mathematical models are discussed by correlating them with the observed characteristics of cellulose.

  7. Los Alamos National Laboratory Yucca Mountain Site Characterization Project 1994 quality program status report

    Energy Technology Data Exchange (ETDEWEB)

    Bolivar, S.L.

    1996-03-01

    This status report is for calendar year 1994. It summarizes the annual activities and accomplishments of the Los Alamos National Laboratory Yucca Mountain Site Characterization Project (YMP or Project) quality assurance program. By identifying the accomplishments of the quality program, a baseline is established that will assist in decision making, improve administrative controls and predictability, and allow us to annually identify adverse trends and to evaluate improvements. This is the fourth annual status report.

  8. Site Characterization for AAH/HELLFIRE Battlefield Obscuration Validation Tests at Redstone Arsenal, Alabama.

    Science.gov (United States)

    1981-12-01

    Link, Chief, Environmental Constraints Group. The work was performed by Messrs. James Mason and Carlos Lebron , EL. This report was prepared by the...PERFORMING ORG. REPORT NUMBER 7. AU THOR(.) 9. CONTRACT OR" GRANT NUMBER(e.) James B. Mason, Katherine S. Long Intra-Army order No. SOXl 9. PERFORMING...reproduced below. Mason. James B. Site characterization for AAII/IELLFIRE Battlefield Obscuration Validation Tests at Redstone Arsenal / t. by James B. Mason

  9. A Simple Tool to Identify Representative Wind Sites for Air Pollution Modelling Applications

    Directory of Open Access Journals (Sweden)

    M. A. Elangasinghe

    2016-01-01

    Full Text Available This paper investigates the use of the Site-Optimized Semiempirical (SOSE air pollution model to identify the surface wind measurement site characteristics that yield the best air pollution predictions for urban locations. It compares the modelling results from twelve meteorological sites with varying anemometer heights, located at different distances from the air pollution measurements and exhibiting different land use characteristics. The results show that the index of agreement (IA between observed and predicted concentrations can be improved from 0.4 to 0.8 by using the most compared to the least representative wind data as input to the air pollution model. Although improvements can be achieved using wind data from a site closer to the air quality monitoring site, choosing the closest wind site does not necessarily yield the best results, especially if the meteorological station is located in a region of complex land use. In addition, both the height of the anemometer and the openness of the terrain surrounding the anemometer were found to be equally important in obtaining good model predictions. The simple SOSE model can therefore be used to complement regulatory meteorological guidelines by providing a quantitative assessment of wind site representativeness for air quality applications in complex urban environments.

  10. Online characterization of planetary surfaces: PlanetServer, an open-source analysis and visualization tool

    Science.gov (United States)

    Marco Figuera, R.; Pham Huu, B.; Rossi, A. P.; Minin, M.; Flahaut, J.; Halder, A.

    2018-01-01

    The lack of open-source tools for hyperspectral data visualization and analysis creates a demand for new tools. In this paper we present the new PlanetServer, a set of tools comprising a web Geographic Information System (GIS) and a recently developed Python Application Programming Interface (API) capable of visualizing and analyzing a wide variety of hyperspectral data from different planetary bodies. Current WebGIS open-source tools are evaluated in order to give an overview and contextualize how PlanetServer can help in this matters. The web client is thoroughly described as well as the datasets available in PlanetServer. Also, the Python API is described and exposed the reason of its development. Two different examples of mineral characterization of different hydrosilicates such as chlorites, prehnites and kaolinites in the Nili Fossae area on Mars are presented. As the obtained results show positive outcome in hyperspectral analysis and visualization compared to previous literature, we suggest using the PlanetServer approach for such investigations.

  11. Topographical survey and soil characterization of a candidate site for Radioactive Waste Repository

    Energy Technology Data Exchange (ETDEWEB)

    Peconick, Diva Godoi de O.; Mourao, Rogerio P., E-mail: godiva@cdtn.br, E-mail: mouraor@cdtn.br [Centro de Desenvolvimento da Tecnologia Nucelar (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2015-07-01

    Brazil has already initiated the establishment of a national near-surface repository for the low- and intermediate short-lived radioactive wastes generated within its territory. With two nuclear power plants in operation and a third one under construction, five active nuclear research institutes and another one planned for the intermediate future, operational constraints and social pressure built up for a disposal solution for such a waste category. The Brazilian Nuclear Commission CNEN was tasked at designing, building and commissioning this repository, which implies, among other activities, finding a suitable place for the facility. After an initial technical desk job, a federal land, not far from the NPPs, was appointed and in situ studies for the site characterization were started. This paper describes the topographical survey and soil drilling campaign carried out for the initial evaluation of the feasibility of the site vis-a-vis the applicable national regulations for site selection and disposal facilities licensing. (author)

  12. BACTIBASE second release: a database and tool platform for bacteriocin characterization

    Directory of Open Access Journals (Sweden)

    Ben Hamida Jeannette

    2010-01-01

    Full Text Available Abstract Background BACTIBASE is an integrated open-access database designed for the characterization of bacterial antimicrobial peptides, commonly known as bacteriocins. Description For its second release, BACTIBASE has been expanded and equipped with additional functions aimed at both casual and power users. The number of entries has been increased by 44% and includes data collected from published literature as well as high-throughput datasets. The database provides a manually curated annotation of bacteriocin sequences. Improvements brought to BACTIBASE include incorporation of various tools for bacteriocin analysis, such as homology search, multiple sequence alignments, Hidden Markov Models, molecular modelling and retrieval through our taxonomy Browser. Conclusion The provided features should make BACTIBASE a useful tool in food preservation or food safety applications and could have implications for the development of new drugs for medical use. BACTIBASE is available at http://bactibase.pfba-lab-tun.org.

  13. Tunable mechanical monolithic sensors for large band low frequency monitoring and characterization of sites and structures

    Science.gov (United States)

    Barone, F.; Giordano, G.; Acernese, F.; Romano, R.

    2016-10-01

    Among the different mechanical architectures present in literature, the Watts linkage is one of the most promising ones for the implementation of a new class of mechanical accelerometers (horizontal, vertical and angular). In this paper, we present monolithic implementations of uniaxial and triaxial mechanical seismometers and accelerometers based on the UNISA Folded Pendulum mechanical configuration, optimized for low frequency characterization of sites (including underground sites) and structures as inertial sensor (seismometer). This mechanical architecture allows the design and implementation of very large band monolithic sensors (10-7Hz 102 Hz), whose sensitivities for the most common applications are defined by the noise introduced by their readouts (e.g. ¡ 10-12 m/sqrt(Hz) with classical LVDT readouts). These unique features, coupled other relevant properties like scalability, compactness, lightness, high directivity, frequency tunability (typical resonance frequencies in the band 10-1 Hz 102 Hz), very high immunity to environmental noises and low cost make this class of sensors very effective for the implementation of uniaxial (horizontal and/or vertical) and triaxial seismometers and accelerometers for ground, space and underwater applications, including UHV and cryogenics ones. Typical applications of this class of monolithic sensors are in the field of earthquake engineering, seismology, geophysics, civil engineering, characterization of sites (including underground sites), structures (e.g. buildings, bridges, historical monuments), and, in general, in all applications requiring large band-low frequency performances coupled with high sensitivities and compactness.

  14. Site characterization progress report: Yucca Mountain, Nevada. Number 15, April 1--September 30, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    During the second half of fiscal year 1996, activities at the Yucca Mountain Site Characterization Project (Project) supported the objectives of the revised Program Plan released this period by the Office of Civilian Radioactive Waste Management of the US Department of Energy (Department). Outlined in the revised plan is a focused, integrated program of site characterization, design, engineering, environmental, and performance assessment activities that will achieve key Program and statutory objectives. The plan will result in the development of a license application for repository construction at Yucca Mountain, if the site is found suitable. Activities this period focused on two of the three near-term objectives of the revised plan: updating in 1997 the regulatory framework for determining the suitability of the site for the proposed repository concept and providing information for a 1998 viability assessment of continuing toward the licensing of a repository. The Project has also developed a new design approach that uses the advanced conceptual design published during the last reporting period as a base for developing a design that will support the viability assessment. The initial construction phase of the Thermal Testing Facility was completed and the first phase of the in situ heater tests began on schedule. In addition, phase-one construction was completed for the first of two alcoves that will provide access to the Ghost Dance fault.

  15. Comparison of in silico tools for binding site prediction applied for structure-based design of autolysin inhibitors.

    Science.gov (United States)

    Tibaut, T; Borišek, J; Novič, M; Turk, D

    2016-07-01

    Autolysin E (AtlE) is a bacteriolytic enzyme which plays an important role in division and growth of bacterial cells and therefore represents a promising potential drug target. Its 3D structure has been recently elucidated. We used in silico prediction tools to study substrate or ligand (inhibitor) binding regions of AtlE. We applied several freely available tools and a commercial tool for binding site identification and compared results of the prediction. Calculation time, number of predictions and output data provided by specific software vary according to the different approaches utilized by specific method categories. Despite different approaches, binding sites in similar locations on the protein were predicted. Specific amino acid residues that form these binding sites were predicted as binding residues. The predicted residues, especially those with predicted highest conservation score, could theoretically have catalytic and binding properties. According to our results, we assume that E138, which has the highest conservation score, is the catalytic residue and F161, G162 and Y224, which are also highly conserved, are responsible for substrate binding. Ligands developed with binding specificity towards these residues could inhibit the catalysis and binding of the substrate of AtlE. The molecules with inhibitory potency could therefore represent potential new antibacterial agents.

  16. Information needs for characterization of high-level waste repository sites in six geologic media. Volume 2. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1985-05-01

    Volume II contains appendices for the following: (1) remote sensing and surface mapping techniques; (2) subsurface mapping methods for site characterization; (3) gravity technique; (4) audio-frequency magnetotelluric technique; (5) seismic refraction technique; (6) direct-current electrical resistivity method; (7) magnetic technique; (8) seismic reflection technique; (9) seismic crosshole method; (10) mechanical downhole seismic velocity survey method; (11) borehole geophysical logging techniques; (12) drilling and coring methods for precharacterization studies; (13) subsurface drilling methods for site characterization; (14) geomechanical/thermomechanical techniques for precharacterization studies; (15)geomechanical/thermal techniques for site characterization studies; (16) exploratory geochemical techniques for precharacterization studies; (17) geochemical techniques for site characterization; (18) hydrologic techniques for precharacterization studies; (19) hydrologic techniques for site characterization; and (20) seismological techniques.

  17. Using an innovative criteria weighting tool for stakeholders involvement to rank MSW facility sites with the AHP.

    Science.gov (United States)

    De Feo, Giovanni; De Gisi, Sabino

    2010-11-01

    The main aim of this study was to verify the efficacy of using an innovative criteria weighting tool (the "priority scale") for stakeholders involvement to rank a list of suitable municipal solid waste (MSW) facility sites with the multi-criteria decision-making (MCDM) technique known as analytic hierarchy process (AHP). One of the main objectives of the study was to verify the behaviour of the "priority scale" with both technical and non-technical decision-makers. All over the world, the siting of MSW treatment or disposal plants is a complex process involving politicians, technicians as well as citizens, where stakeholders who are not effectively involved strongly oppose (or even obstruct) the realization of new facilities. In this study, in order to pursue both the technical (select the best site) and social aims (all the stakeholders have to give their aware contribution), the use of the "priority scale" is suggested as a tool to easily collect non-contradictory criteria preferences by the various decision-makers. Every decision-maker filled in "priority scale", which was subsequently uploaded in the AHP tool in order to indirectly calculate the individual priority of alternatives given by each stakeholder (not using group aggregation techniques). The proposed method was applied to the siting of a composting plant in an area suffering from a serious MSW emergency, which has lasted for over 15 years, in the Campania Region, in Southern Italy. The best site (the "first choice") was taken as the one that appeared the most times at the first place of each decision-maker ranking list. The involved technical and non-technical decision-makers showed the same behaviour in (indirectly) selecting the best site as well as in terms of the most appraised criteria ("absence of areas of the highest value for natural habitats and species of plants and animals"). Moreover, they showed the same AHP inconsistency ratio as well as the same behaviour in comparison with a "balanced

  18. A Ten Step Protocol and Plan for CCS Site Characterization, Based on an Analysis of the Rocky Mountain Region, USA

    Energy Technology Data Exchange (ETDEWEB)

    McPherson, Brian; Matthews, Vince

    2013-09-15

    This report expresses a Ten-Step Protocol for CO2 Storage Site Characterization, the final outcome of an extensive Site Characterization analysis of the Rocky Mountain region, USA. These ten steps include: (1) regional assessment and data gathering; (2) identification and analysis of appropriate local sites for characterization; (3) public engagement; (4) geologic and geophysical analysis of local site(s); (5) stratigraphic well drilling and coring; (6) core analysis and interpretation with other data; (7) database assembly and static model development; (8) storage capacity assessment; (9) simulation and uncertainty assessment; (10) risk assessment. While the results detailed here are primarily germane to the Rocky Mountain region, the intent of this protocol is to be portable or generally applicable for CO2 storage site characterization.

  19. Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior.

    Science.gov (United States)

    Hirschberg, Cosima; Boetker, Johan P; Rantanen, Jukka; Pein-Hackelbusch, Miriam

    2018-02-01

    There is an increasing need to provide more detailed insight into the behavior of particulate systems. The current powder characterization tools are developed empirically and in many cases, modification of existing equipment is difficult. More flexible tools are needed to provide understanding of complex powder behavior, such as mixing process and segregation phenomenon. An approach based on the fast prototyping of new powder handling geometries and interfacing solutions for process analytical tools is reported. This study utilized 3D printing for rapid prototyping of customized geometries; overall goal was to assess mixing process of powder blends at small-scale with a combination of spectroscopic and mechanical monitoring. As part of the segregation evaluation studies, the flowability of three different paracetamol/filler-blends at different ratios was investigated, inter alia to define the percolation thresholds. Blends with a paracetamol wt% above the percolation threshold were subsequently investigated in relation to their segregation behavior. Rapid prototyping using 3D printing allowed designing two funnels with tailored flow behavior (funnel flow) of model formulations, which could be monitored with an in-line near-infrared (NIR) spectrometer. Calculating the root mean square (RMS) of the scores of the two first principal components of the NIR spectra visualized spectral variation as a function of process time. In a same setup, mechanical properties (basic flow energy) of the powder blend were monitored during blending. Rapid prototyping allowed for fast modification of powder testing geometries and easy interfacing with process analytical tools, opening new possibilities for more detailed powder characterization.

  20. Characterization of candidate DOE sites for fabricating MOX fuel for lead assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Holdaway, R.F.; Miller, J.W.; Sease, J.D.; Moses, R.J.; O`Connor, D.G. [Oak Ridge National Lab., TN (United States); Carrell, R.D. [Technical Resources International, Inc., Richland, WA (United States); Jaeger, C.D. [Sandia National Labs., Albuquerque, NM (United States); Thompson, M.L.; Strasser, A.A. [Delta-21 Resources, Inc., Oak Ridge, TN (United States)

    1998-03-01

    The Office of Fissile Materials Disposition (MD) of the Department of Energy (DOE) is directing the program to disposition US surplus weapons-usable plutonium. For the reactor option for disposition of this surplus plutonium, MD is seeking to contract with a consortium, which would include a mixed-oxide (MOX) fuel fabricator and a commercial US reactor operator, to fabricate and burn MOX fuel in existing commercial nuclear reactors. This option would entail establishing a MOX fuel fabrication facility under the direction of the consortium on an existing DOE site. Because of the lead time required to establish a MOX fuel fabrication facility and the need to qualify the MOX fuel for use in a commercial reactor, MD is considering the early fabrication of lead assemblies (LAs) in existing DOE facilities under the technical direction of the consortium. The LA facility would be expected to produce a minimum of 1 metric ton heavy metal per year and must be operational by June 2003. DOE operations offices were asked to identify candidate sites and facilities to be evaluated for suitability to fabricate MOX fuel LAs. Savannah River Site, Argonne National Laboratory-West, Hanford, Lawrence Livermore National Laboratory, and Los Alamos National Laboratory were identified as final candidates to host the LA project. A Site Evaluation Team (SET) worked with each site to develop viable plans for the LA project. SET then characterized the suitability of each of the five plans for fabricating MOX LAs using 28 attributes and documented the characterization to aid DOE and the consortium in selecting the site for the LA project. SET concluded that each option has relative advantages and disadvantages in comparison with other options; however, each could meet the requirements of the LA project as outlined by MD and SET.

  1. Social networking sites as business tool: a study of user behavior

    NARCIS (Netherlands)

    Constantinides, Efthymios; Lorenzo-Romero, C.; Alarcon-del-Amo, M.d.C.; Glykas, M.

    2013-01-01

    Social Networking Sites (SNS) are second generation web applications allowing the creation of personal online networks; the social networking domain has become one of the fastest growing online environments connecting hundreds of millions of people worldwide. Businesses are increasingly interested

  2. p53 binding sites in normal and cancer cells are characterized by distinct chromatin context.

    Science.gov (United States)

    Bao, Feifei; LoVerso, Peter R; Fisk, Jeffrey N; Zhurkin, Victor B; Cui, Feng

    2017-08-18

    The tumor suppressor protein p53 interacts with DNA in a sequence-dependent manner. Thousands of p53 binding sites have been mapped genome-wide in normal and cancer cells. However, the way p53 selectively binds its cognate sites in different types of cells is not fully understood. Here, we performed a comprehensive analysis of 25 published p53 cistromes and identified 3,551 and 6,039 'high-confidence' binding sites in normal and cancer cells, respectively. Our analysis revealed 2 distinct epigenetic features underlying p53-DNA interactions in vivo. First, p53 binding sites are associated with transcriptionally active histone marks (H3K4me3 and H3K36me3) in normal-cell chromatin, but with repressive histone marks (H3K27me3) in cancer-cell chromatin. Second, p53 binding sites in cancer cells are characterized by a lower level of DNA methylation than their counterparts in normal cells, probably related to global hypomethylation in cancers. Intriguingly, regardless of the cell type, p53 sites are highly enriched in the endogenous retroviral elements of the ERV1 family, highlighting the importance of this repeat family in shaping the transcriptional network of p53. Moreover, the p53 sites exhibit an unusual combination of chromatin patterns: high nucleosome occupancy and, at the same time, high sensitivity to DNase I. Our results suggest that p53 can access its target sites in a chromatin environment that is non-permissive to most DNA-binding transcription factors, which may allow p53 to act as a pioneer transcription factor in the context of chromatin.

  3. U.S. Department of Energy's site screening, site selection, and initial characterization for storage of CO2 in deep geological formations

    Science.gov (United States)

    Rodosta, T.D.; Litynski, J.T.; Plasynski, S.I.; Hickman, S.; Frailey, S.; Myer, L.

    2011-01-01

    The U.S. Department of Energy (DOE) is the lead Federal agency for the development and deployment of carbon sequestration technologies. As part of its mission to facilitate technology transfer and develop guidelines from lessons learned, DOE is developing a series of best practice manuals (BPMs) for carbon capture and storage (CCS). The "Site Screening, Site Selection, and Initial Characterization for Storage of CO2 in Deep Geological Formations" BPM is a compilation of best practices and includes flowchart diagrams illustrating the general decision making process for Site Screening, Site Selection, and Initial Characterization. The BPM integrates the knowledge gained from various programmatic efforts, with particular emphasis on the Characterization Phase through pilot-scale CO2 injection testing of the Validation Phase of the Regional Carbon Sequestration Partnership (RCSP) Initiative. Key geologic and surface elements that suitable candidate storage sites should possess are identified, along with example Site Screening, Site Selection, and Initial Characterization protocols for large-scale geologic storage projects located across diverse geologic and regional settings. This manual has been written as a working document, establishing a framework and methodology for proper site selection for CO2 geologic storage. This will be useful for future CO2 emitters, transporters, and storage providers. It will also be of use in informing local, regional, state, and national governmental agencies of best practices in proper sequestration site selection. Furthermore, it will educate the inquisitive general public on options and processes for geologic CO2 storage. In addition to providing best practices, the manual presents a geologic storage resource and capacity classification system. The system provides a "standard" to communicate storage and capacity estimates, uncertainty and project development risk, data guidelines and analyses for adequate site characterization, and

  4. Site characterization investigations at Oak Ridge National Laboratory. [Shallow land burial

    Energy Technology Data Exchange (ETDEWEB)

    Ketelle, R.H.

    1985-01-01

    The geologic and geohydrologic characterization and assessment techniques currently used at ORNL are integrated into a systematic approach. The investigations are multi-faceted, and involve investigators with a variety of expertise. Characterization studies are designed to obtain the data requirements of pathways analysis and facility design in addition to the detailed site description. The approach effectively minimizes the redundancy and lack of coordination which often arise when the study is broken down into totally independent tasks. The geologic environment of the Oak Ridge Reservation is one of structural and stratigraphic complexity which requires a comprehensive and systematic approach to characterize. Recent characterization studies have included state-of-the-science techniques in the areas of unsaturated zone testing, geochemical tests to determine attenuation properties of soils, and numerical analyses of site performance. The results of these studies and analyses are changing the technology of shallow land burial by indicating that chemically stable waste forms are required to limit radionuclide migration to acceptable levels. 11 refs., 1 tab.

  5. DEVELOPING A MOBILE SITE USING KOODIVIIDAKKO CONTENT MANAGEMENT SYSTEM TOOL – SIVUVIIDAKKO

    OpenAIRE

    Wang, Yini

    2013-01-01

    Antell is a nationally renowned family company which has business of staff restaurant, café and bakery. In 2012 they decided to renew their website. An advertisement agency has the designed the new web site look. The desktop web site is implemented with a Content Management System called Sivuviidakko, which is a product of Koodiviidakko used to manage the content and appearance of a website. Koodiviidakko is a young and agile company specialized in digital marketing and communication sof...

  6. Drooping as a simple characterization tool for extraction efficiency and optical losses in light emitting diodes

    Science.gov (United States)

    Oksanen, Jani; Tulkki, Jukka

    2010-09-01

    We extend the previous droop models developed for InGaN light emitting diodes (LEDs) by accounting for the light extraction and show that drooping can be used to quantify both the extraction efficiency and the optical losses in LEDs. Our model allows very simple characterization of LEDs by an integrating sphere and therefore provides an attractive characterization tool to measure the most important loss parameters of various LED structures. In particular, the approach allows evaluation of the effects of various optical losses and photon recycling on the efficiency and consequently allows more efficient optimization of the LED structures. As an additional benefit, our measurement method does not necessarily require any fitting of the data.

  7. The Petrology of the Wong Tei Tung Stone Tool Manufacturing Site, Sham Chung, Hong Kong Sar, China

    Directory of Open Access Journals (Sweden)

    Vin Davis

    2009-09-01

    Full Text Available The Wong Tei Tung archaeological site was discovered in 2003. Two periods have been proposed: an earlier period dating to around 40,000 years bp, and a later period dating to around 7000 years bp, but these dates should be treated cautiously. Initially, reported research found a few traits of the Wong Tei Tung assemblage to be similar to South-east Asia lithics, especially the short axe and Sumatralith cores. It has been reported that the Wong Tei Tung assemblage is a lithic cluster of certain 'techno-complex' implements rather than an archaeological culture; it offers a glimpse of lithic manufacturing in adaptation to its particular coastal environment. The published evidence points to a production of stone tools that considerably exceeded anticipated immediate local need. It is likely, therefore, that products from the site were distributed widely across the Zhujiang Estuary (Pearl River area and beyond (Fig. 1: map. This article presents the results of initial investigations into the geological setting of the site; provides new petrographic descriptions using data obtained from thin sections and geochemical analyses; and makes tentative comparisons with similar archaeological stone tool manufacturing sites in Britain.

  8. Geomorphological and geophysical investigations for the characterization of the Roman Carsulae site (Tiber basin, Central Italy)

    Science.gov (United States)

    Bottari, C.; Aringoli, D.; Carluccio, R.; Castellano, C.; D'Ajello Caracciolo, F.; Gasperini, M.; Materazzi, M.; Nicolosi, I.; Pambianchi, G.; Pieruccini, P.; Sepe, V.; Urbini, S.; Varazi, F.

    2017-08-01

    This paper aims to bring to light the possible linkage between karstic phenomena and the human occupation of the Roman site of Carsulae (Tiber basin, Central Italy). Dolines are a typical morphological expression of karst rocks' dissolution and collapse and, usually, they represent a potential hazard for human activities and, in particular, in the care and maintenance of cultural heritage sites. In this study, we observed that the development of a subsidence doline caused severe damage to some archaeological structures at the Carsulae monumental site. According to the results obtained in our investigation, three sites at least with karst dissolution phenomena in the shallow calcareous tufa layer have been identified. One of them subsided probably in Roman times and produced a sharp deformation of the decumanus. In order to understand the evolution of this territory an integrated geomorphological and geophysical survey was carried out. The combination between the information derived from different geophysical techniques, such as: Electrical Resistivity Tomography (ERT), Frequency-Domain Electromagnetism (FDEM), and Ground Penetrating Radar (GPR) clearly pointed out that the calcareous tufa layer is characterized by an irregular geometry and this resulted in the investigated area being affected by karst dissolution in several parts. Four boreholes opportunely located, provided direct information about the depth and the alteration of the calcareous tufa basement and precious calibration data for the geophysical methods. This study contributes to improving our knowledge on the evolution of the Carsulae archaeological site providing a new insight into the adaptation of ancient human societies in this problematic territory.

  9. Cloning and characterization of a variant surface glycoprotein expression site from Trypanosoma equiperdum.

    Science.gov (United States)

    Raibaud, A; Buck, G; Baltz, T; Eisen, H

    1986-08-01

    Variant surface glycoprotein (VSG) genes of African trypanosomes are expressed when they are inserted into one of several telomere-linked expression sites. We cloned and characterized an 11-kilobase (kb) DNA fragment located upstream of an expressed VSG gene. A DNA sequence of 1.8 kb that is located immediately upstream of the inserted VSG gene contains sequences homologous to the 76-base-pair repeats described as being upstream of VSG genes in Trypanosoma brucei (D. A. Campbell, M. P. Van Bree, and J. C. Boothroyd, Nucleic Acids Res. 12:2759-2774). There are no such sequences elsewhere in the 11-kb cloned region. Southern blot analysis using probes from the cloned region revealed multiple unlinked copies of the same or very similar regions. At least three of these are located near telomeres, and two have been shown to be used for the expression of known Trypanosoma equiperdum VSG genes. Like VSG genes, the upstream sequences themselves can be duplicated and deleted. The choice of expression site to be used by a duplicated VSG gene is nonrandom; the site used for expression of the parental VSG gene is strongly favored for use in the daughter variant. Furthermore, even when the parental expression site is not used, the VSG gene occupying it is replaced. Thus, an active expression site is a preferential target for gene conversion in the next variation event.

  10. Selection of a tool to decision making for site selection for high level waste

    Directory of Open Access Journals (Sweden)

    Guiller Madeira Jonni

    2016-01-01

    Full Text Available The aim of this paper is to create a panel comparing some of the key decision-making support tools used in situations with the characteristics of the problem of selecting suitable areas for constructing a final deep geologic repository. The tools addressed in this work are also well known and with easy implementation. The decision-making process in matters of this kind is, in general, complex due to its multicriteria nature and the conflicting opinions of various stakeholders. Thus, a comprehensive study was performed with the literature in this subject, specifically in documents of the International Atomic Energy Agency (IAEA, regarding the importance of the criteria involved in the decision-making process. Therefore, we highlighted six judgment attributes for selecting a decision support tool, suitable for the problem. For this study, we have selected the following multicriteria tools: AHP, Delphi, Brainstorm, Nominal Group Technique and AHP-Delphi. Finally, the AHP-Delphi method has demonstrated to be more appropriate for managing the inherent multiple attributes to the problem proposed.

  11. A risk assessment tool for contaminated sites in low-permeability fractured media

    DEFF Research Database (Denmark)

    Chambon, Julie Claire Claudia; Binning, Philip John; Jørgensen, Peter R.

    2011-01-01

    and history (including secondary sources) and can be applied to a wide range of compounds. The tool successfully simulates published data from short duration column and field experiments. The use for risk assessment is illustrated by three typical risk assessment case studies, involving pesticides...

  12. Whiteboards and Web Sites: Digital Tools for the Early Childhood Curriculum

    Science.gov (United States)

    Lisenbee, Peggy

    2009-01-01

    Incorporating technology into the early childhood classroom to enhance traditional teaching methods is not a new idea. Yet the use of technology as an instructional tool in curriculum is still often considered an innovative way to engage young children in learning. Since "computers serve as catalysts for social interaction", the use of technology…

  13. High Resolution Site Characterization as key element for proper design and cost estimation of groundwater remediation

    Directory of Open Access Journals (Sweden)

    Pieter Dijkshoorn

    2014-12-01

    Full Text Available Substantial amounts of money are spent each year on cleaning up ground water contaminations that were caused by historical industrial site activities. Too often, however, remedial objectives are not achieved within the anticipated time frame. Moreover, remedial budgets which were estimated prior to the start of remediation turn out to be largely insufficient to meet the remedial objectives. This situation, very common, creates significant troubles for all the stakeholders involved in the remediation project. The reason for not meeting remedial regulatory closure criteria or exceeding remedial budgets is often due to an incomplete conceptual site model. Having conducted high resolution site characterization programs at numerous sites where remediation was previously conducted, ERM has found several recurring themes: • Missed source areas and plumes; • Inadequate understanding of source area and plume architectures (i.e., three-dimensional contaminant distribution; • Inadequate understanding of the effects of site (hydrogeologic conditions on the ability to access contamination (i.e., via remedial additive injections of groundwater/soil gas extraction. This paper explains why remediations often fail and what the alternatives to prevent these failures (and exceeding remedial budgets are. More specifically, it focuses on alternative investigation methods and approaches that help to get to a more complete (high resolution conceptual site model. This more complete conceptual site model in return helps a more focused remedial design with a higher remedial efficiency. As a minimum, it will take away a lot of (financial uncertainty during the decision making when selecting a remedial alternative. Contaminants that have a greater density then water are known to have a greater complexity in terms of both investigation as well as remediation. Therefore, they will be the main focus of this paper.

  14. Simultaneous Ka-Band Site Characterization: Goldstone, CA, White Sands, NM, and Guam, USA

    Science.gov (United States)

    Acosta, Roberto; Morse, Jacquelynne; Zemba, Michael; Nessel, James; Morabito, David; Caroglanian, Armen

    2011-01-01

    To statistically characterize atmospheric effects on Ka-band links at NASA operational sites, NASA has constructed site test interferometers (STI s) which directly measure the tropospheric phase stability and rain attenuation. These instruments observe an unmodulated beacon signal broadcast from a geostationary satellite (e.g., Anik F2) and measure the phase difference between the signals received by the two antennas and its signal attenuation. Three STI s have been deployed so far: the first one at the NASA Deep Space Network Tracking Complex in Goldstone, California (May 2007); the second at the NASA White Sands Complex, in Las Cruses, New Mexico (February 2009); and the third at the NASA Tracking and Data Relay Satellite (TDRS) Remote Ground Terminal (GRGT) complex in Guam (May 2010). Two station-years of simultaneous atmospheric phase fluctuation data have been collected at Goldstone and White Sands, while one year of data has been collected in Guam. With identical instruments operating simultaneously, we can directly compare the phase stability and rain attenuation at the three sites. Phase stability is analyzed statistically in terms of the root-mean-square (rms) of the tropospheric induced time delay fluctuations over 10 minute blocks. For two years, the time delay fluctuations at the DSN site in Goldstone, CA, have been better than 2.5 picoseconds (ps) for 90% of the time (with reference to zenith), meanwhile at the White Sands, New Mexico site, the time delay fluctuations have been better than 2.2 ps with reference to zenith) for 90% of time. For Guam, the time delay fluctuations have been better than 12 ps (reference to zenith) at 90% of the time, the higher fluctuations are as expected from a high humidity tropical rain zone. This type of data analysis, as well as many other site quality characteristics (e.g., rain attenuation, infrastructure, etc.) will be used to determine the suitability of all the sites for NASA s future communication services at Ka-band.

  15. Characterization of the Copper(II) Binding Sites in Human Carbonic Anhydrase II

    Science.gov (United States)

    Nettles, Whitnee L.; Song, He; Farquhar, Erik R.; Fitzkee, Nicholas C.; Emerson, Joseph P.

    2015-01-01

    Human carbonic anhydrase (CA) is a well-studied, robust, mononuclear Zn-containing metalloprotein that serves as an excellent biological ligand system to study the thermodynamics associated with metal ion coordination chemistry in aqueous solution. The apo-form of human carbonic anhydrase II (CA) binds two equivalents of copper(II) with high affinity. The Cu2+ ions bind independently forming two non-coupled type-II copper centers in CA (CuA and CuB). However, the location and coordination mode of the CuA site in solution is unclear, compared to the CuB site that has been well characterized. Using paramagnetic NMR techniques and X-ray absorption spectroscopy we have identified an N-terminal Cu2+ binding location and collected information on the coordination mode of the CuA site in CA, which is consistent with a four to five coordinate N-terminal Cu2+ binding site reminiscent to a number of N-terminal copper(II) binding sites including the copper(II)-ATCUN and copper(II)-beta-amyloid complexes. Additionally, we report a more detailed analysis of the thermodynamics associated with copper(II) binding to CA. Although we are still unable to fully deconvolute Cu2+ binding data to the high-affinity CuA site, we have derived pH- and buffer-independent values for the thermodynamics parameters K and ΔH associated with Cu2+ binding to the CuB site of CA to be 2 × 109 and −17.4 kcal/mol, respectively. PMID:26010488

  16. A multiattribute utility analysis of sites nominated for characterization for the first radioactive-waste repository: A decision-aiding methodology

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1986-05-01

    In December 1984, the Department of Energy (DOE) published draft environmental assessments (EAs) to support the proposed nomination of five sites and the recommendation of three sites for characterization for the first radioactive-waste repository. A chapter common to all the draft EAs (Chapter 7) presented rankings of the five sites against the postclosure and the preclosure technical siting guidelines. To determine which three sites appeared most favorable for recommendation for characterization, three simple quantitative methods were used to aggregate the rankings assigned to each site for the various technical guidelines. In response to numerous comments on the methods, the DOE has undertaken a formal application of one of them (hereafter referred to as the decision-aiding methodology) for the purpose of obtaining a more rigorous evaluation of the nominated sites. The application of the revised methodology is described in this report. The method of analysis is known as multiattribute utility analysis; it is a tool for providing insights as to which sites are preferable and why. The decision-aiding methodology accounts for all the fundamental considerations specified by the siting guidelines and uses as source information the data and evaluations reported or referenced in the EAs. It explicitly addresses the uncertainties and value judgments that are part of all siting problems. Furthermore, all scientific and value judgments are made explicit for the reviewer. An independent review of the application of the decision-aiding methodology has been conducted by the Board on Radioactive Waste Management of the National Academy of Sciences; the comments of the Board are included as an appendix to this report.

  17. Innovations in Site Characterization: Streamlining Cleanup at Vapor Intrusion and Product Removal Sites Using the Triad Approach: Hartford Plume Site, Hartford, Illinois

    Science.gov (United States)

    The Hartford Plume Site case study provides a detailed example of the strategies and technologies used at the site that are available to environmental practitioners to use at large and small hydrocarbon sites.

  18. Site characterization report for the Old Hydrofracture Facility at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-01-01

    Several Old Hydrofracture Facility (OHF) structures (i.e., Building 7852, the bulk storage bins, the pump house, water tank T-5, and pump P-3) are surplus facilities at Oak Ridge National Laboratory (ORNL) slated for decontamination and decommissioning (D and D). OHF was constructed in 1963 to allow experimentation and operations with an integrated solids storage, handling, mixing, and grout injection facility. It was shut down in 1980 and transferred to ORNL`s Surveillance and Maintenance Program. The hydrofracture process was a unique disposal method that involved injecting waste materials mixed with grout and additives under pumping pressures of 2,000 psi or greater into a deep, low-permeability shale formation. The injected slurry spread along fractures and bedding planes for hundreds of feet from the injection points, forming thin grout sheets (often less than 1/8 in. thick). The grout ostensibly immobilized and solidified the liquid wastes. Site characterization activities were conducted in the winter and spring of 1994 to collect information necessary to plan the D and D of OHF structures. This site characterization report documents the results of the investigation of OHF D and D structures, presenting data from the field investigation and laboratory analyses in the form of a site description, as-built drawings, summary tables of radiological and chemical contaminant concentrations, and a waste volume estimate. 25 refs., 54 figs., 17 tabs.

  19. Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC

    DEFF Research Database (Denmark)

    Rosenbaek, L L; Assentoft, Mette; Pedersen, Nis Borbye

    2012-01-01

    The sodium-chloride cotransporter, NCC, is essential for renal electrolyte balance. NCC function can be modulated by protein phosphorylation. In this study, we characterized the role and physiological regulation of a novel phosphorylation site in NCC at Ser124 (S124). Novel phospho-specific antib......The sodium-chloride cotransporter, NCC, is essential for renal electrolyte balance. NCC function can be modulated by protein phosphorylation. In this study, we characterized the role and physiological regulation of a novel phosphorylation site in NCC at Ser124 (S124). Novel phospho......DAVP significantly increased pS124-NCC abundance, with no changes in total NCC plasma membrane abundance. pS124-NCC levels also increased in abundance in rats after stimulation of the renin-angiotensin-aldosterone system by dietary low sodium intake. In contrast to other NCC phosphorylation sites, the STE20/SPS1......-related proline-alanine-rich kinase and oxidative stress-response kinases (SPAK and OSR1) were not able to phosphorylate NCC at S124. Protein kinase arrays identified multiple kinases that were able to bind to the region surrounding S124. Four of these kinases (IRAK2, CDK6/Cyclin D1, NLK and m...

  20. Development of Tools and Techniques to Survey, Assess, Stabilise, Monitor and Preserve Underwater Archaeological Sites: SASMAP

    Science.gov (United States)

    Gregory, D. J.

    2015-08-01

    SASMAP's purpose is to develop new technologies and best practices in order to locate, assess and manage Europe's underwater cultural heritage in a more effective way than is possible today. SASMAP has taken an holistic- and process- based approach to investigating underwater environments and the archaeological sites contained therein. End user of the results of SASMAP are severalfold; i) to benefiet the SMEs involved in the project and development of their products for the offshore industry (not just for archaeological purposes) ii) a better understanding of the marine environment and its effect on archaeological materials iii) the collation of the results from the project into guidelines that can be used by cultural resource managers to better administer and optimise developer lead underwater archaeological project within Europe in accordance with European legislation (Treaty of Valetta (1992). Summarily the project has utilised a down scaling approach to localise archaeological sites at a large scale regional level. This has involved using innovative satellite imagery to obtain seamless topography maps over coastal areas and the seabed (accurate to a depth of 6m) as well as the development of a 3D sub bottom profiler to look within the seabed. Results obtained from the downscaling approach at the study areas in the project (Greece and Denmark) have enabled geological models to be developed inorder to work towards predictive modelling of where submerged prehistoric sites may be encountered. Once sites have been located an upscaling approach has been taken to assessing an individual site and the materials on and within it in order to better understand the state of preservation and dynamic conditions of a site and how it can best be preserved through in situ preservation or excavation. This has involved the development of equipment to monitor the seabed environment (open water and in sediments), equipment for sampling sediments and assessing the state of

  1. Sandia National Laboratories site-wide hydrogeologic characterization project calendar year 1992 annual report

    Energy Technology Data Exchange (ETDEWEB)

    Crowson, D.; Gibson, J.D.; Haase, C.S.; Holt, R.; Hyndman, D.; Krumhansl, J.; Lauffer, F.; McCord, J.P.; McCord, J.T.; Neel, D. [and others

    1993-10-01

    The Sandia National Laboratories, New Mexico (SNL/NM) Site-Wide Hydrogeologic Characterization (SWHC) project has been implemented as part of the SNL/NM Environmental Restoration (ER) Program to develop the regional hydrogeologic framework and baseline for the approximately 100 mi of Kirtland Air Force Base (KAFB) and adjacent withdrawn public lands upon which SNL/NM has performed research and development activities. Additionally, the SWHC project will investigate and characterize generic hydrogeologic issues associated with the 172 ER sites owned by SNL/NM across its facilities on KAFB. As called for in the Hazardous and Solid Waste Amendments (HSWA) to the Resource Conservation and Recovery Act (RCRA) Part B permit agreement between the U.S. Environmental Protection Agency (EPA) as the permitter and the U.S. Department of Energy (DOE) and SNL/NM as the permittees, an annual report is to be prepared by the SWHC project team. This document serves two primary purposes: (1) to identify and describe the conceptual framework for the hydrogeologic system underlying SNL/NM and (2) to describe characterization activities undertaken in the preceding year that add to our understanding (reduce our uncertainties) regarding the conceptual and quantitative hydrogeologic framework. This SWHC project annual report focuses primarily on purpose 1, providing a summary description of the current {open_quotes}state of knowledge{close_quotes} of the Sandia National Laboratories/Kirtland Air Force Base (SNL/KAFB) hydrogeologic setting.

  2. Guidance Protocol: Application of Nucleic Acid-Based Tools for Monitoring Monitored Natural Attenuation (MNA), Biostimulation, and Bioaugmentation at Chlorinated Solvent Sites

    Science.gov (United States)

    2011-02-01

    MONITORING MONITORED NATURAL ATTENUATION (MNA), BIOSTIMULATION AND BIOAUGMENTATION AT CHLORINATED SOLVENT SITES ESTCP Project ER0518 NAVFAC ESC...of Nucleic Acid-Based Tools for Monitoring Monitored Natural Attenuation (MNA), Biostimulation, and Bioaugmentation at Chlorinated Solvent Sites 5a...Monitoring Monitored Natural Attenuation (MNA), Biostimulation, and Bioaugmentation at Chlorinated Solvent Sites January 2011 ESTCP ER

  3. Seismic Site Characterization through Joint Modeling of Complementary Data Functionals, with Applications to Santo Domingo, Dominican Republic

    Science.gov (United States)

    Schwed, M.; Pulliam, J.; Sen, M. K.; Willemann, R. J.; Huerta-Lopez, C.; Moschetti, M. P.; Schmitz, M.; Louie, J. N.; Polanco, E.; Huerfano Moreno, V.; Pasyanos, M.

    2013-12-01

    New approaches suggest that it may be possible to determine ground shaking during earthquakes through low-cost, non-invasive seismic surveys that make use of ambient noise, and that the results can be used for 'shake-casting' to produce scenarios for the purposes of urban planning, improving community resilience, and emergency response. We will present a strategy for determining seismic 'site characterization' through joint modeling of and horizontal to vertical spectral ratios (HVSR) and surface wave dispersion, determined via spatial autocorrelation (SPAC), refraction microtremor (ReMi), and/or multi-channel analysis of surface waves (MASW). Fitting of data functionals by synthetics is driven by global optimization and the models are assessed quantitatively. The products of this approach are shear wave velocity profiles for the shallow subsurface, accompanied by posterior probability distributions and parameter correlation matrices that allow for the assessment of model reliability. Optimization strategies for solving nonlinear problems in geophysics have several advantages over linearized inversions. Jointly fitting dispersion curves and HVSR functionals via global optimization allows us to characterize the space of possible models, assess model reliability, identify parts of the 'best-fit' model that are poorly constrained, and guide us toward new data that might improve constraints on the model. Tools such as the posterior probability distribution and the parameter correlation matrix allow us to assess the relative contribution of both types of data to model constraints and how to choose the optimal weights between data types. The joint modeling technique is applied to data acquired in an NSF-funded Pan-American Advanced Studies Institute in Santo Domingo, Dominican Republic, entitled 'New Frontiers in Geophysical Research: Bringing New Tools and Techniques to Bear on Earthquake Hazard Analysis and Mitigation', as a proof-of-concept survey in a highly built

  4. Filtration Characterization Method as Tool to Assess Membrane Bioreactor Sludge Filterability—The Delft Experience

    Directory of Open Access Journals (Sweden)

    Maria Lousada-Ferreira

    2014-04-01

    Full Text Available Prevention and removal of fouling is often the most energy intensive process in Membrane Bioreactors (MBRs, responsible for 40% to 50% of the total specific energy consumed in submerged MBRs. In the past decade, methods were developed to quantify and qualify fouling, aiming to support optimization in MBR operation. Therefore, there is a need for an evaluation of the lessons learned and how to proceed. In this article, five different methods for measuring MBR activated sludge filterability and critical flux are described, commented and evaluated. Both parameters characterize the fouling potential in full-scale MBRs. The article focuses on the Delft Filtration Characterization method (DFCm as a convenient tool to characterize sludge properties, namely on data processing, accuracy, reproducibility, reliability, and applicability, defining the boundaries of the DFCm. Significant progress was made concerning fouling measurements in particular by using straight forward approaches focusing on the applicability of the obtained results. Nevertheless, a fouling measurement method is still to be defined which is capable of being unequivocal, concerning the fouling parameters definitions; practical and simple, in terms of set-up and operation; broad and useful, in terms of obtained results. A step forward would be the standardization of the aforementioned method to assess the sludge filtration quality.

  5. Scenarios constructed for basaltic igneous activity at Yucca Mountain and vicinity; Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Barr, G.E.; Dunn, E.; Dockery, H.; Barnard, R. [Sandia National Labs., Albuquerque, NM (United States); Valentine, G.; Crowe, B. [Los Alamos National Lab., NM (United States)

    1993-08-01

    Basaltic volcanism has been identified as a possible future event initiating a release of radionuclides from a potential repository at the proposed Yucca Mountain high-level waste repository site. The performance assessment method set forth in the Site Characterization Plan (DOE, 1988) requires that a set of scenarios encompassing all significant radionuclide release paths to the accessible environment be described. This report attempts to catalogue the details of the interactions between the features and processes produced by basaltic volcanism in the presence of the presumed groundwater flow system and a repository structure, the engineered barrier system (EBS), and waste. This catalogue is developed in the form of scenarios. We define a scenario as a well-posed problem, starting from an initiating event or process and proceeding through a logically connected and physically possible combination or sequence of features, events, and processes (FEPs) to the release of contaminants.

  6. Yucca Mountain Site Characterization Project Bibliography, July--December 1994: An update

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-01

    Following a reorganization of the Office of Civilian Radioactive Waste Management in 1990, the Yucca Mountain Project was renamed Yucca Mountain Site Charactrization Project. The title of this bibliography was also changed to Yucca Mountain Site Characterization Project Bibliography. Prior to August 5, 1988, this project was called the Nevada Nuclear Waste Storage Investigations. This bibliography contains information on this ongoing project that was added to the Department of Energy`s Science and Technology Database from July 1, 1994 through December 31, 1994. The bibliography is categorized by principal project participating organization. Participant-sponsored subcontractor reports, papers, and articles are included in the sponsoring organization`s list. Another section contains information about publications on the Energy Science and Technology Database that were not sponsored by the project but have some relevance to it.

  7. Initial source and site characterization studies for the U.C. Santa Barbara campus

    Energy Technology Data Exchange (ETDEWEB)

    Archuleta, R.; Nicholson, C.; Steidl, J.; Gurrola, L.; Alex, C.; Cochran, E.; Ely, G.; Tyler, T. [University of California, Santa Barbara (United States)

    1997-12-01

    The University of California Campus-Laboratory Collaboration (CLC) project is an integrated 3 year effort involving Lawrence Livermore National Laboratory (LLNL) and four UC campuses - Los Angeles (UCLA), Riverside (UCR), Santa Barbara (UCSB), and San Diego (UCSD) - plus additional collaborators at San Diego State University (SDSU), at Los Alamos National Laboratory and in industry. The primary purpose of the project is to estimate potential ground motions from large earthquakes and to predict site-specific ground motions for one critical structure on each campus. This project thus combines the disciplines of geology, seismology, geodesy, soil dynamics, and earthquake engineering into a fully integrated approach. Once completed, the CLC project will provide a template to evaluate other buildings at each of the four UC campuses, as well as provide a methodology for evaluating seismic hazards at other critical sites in California, including other UC locations at risk from large earthquakes. Another important objective of the CLC project is the education of students and other professional in the application of this integrated, multidisciplinary, state-of-the-art approach to the assessment of earthquake hazard. For each campus targeted by the CLC project, the seismic hazard study will consist of four phases: Phase I - Initial source and site characterization, Phase II - Drilling, logging, seismic monitoring, and laboratory dynamic soil testing, Phase III - Modeling of predicted site-specific earthquake ground motions, and Phase IV - Calculations of 3D building response. This report cover Phase I for the UCSB campus and incudes results up through March 1997.

  8. Environmental assessment for the Groundwater Characterization Project, Nevada Test Site, Nye County, Nevada; Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-08-01

    The US Department of Energy (DOE) proposes to conduct a program to characterize groundwater at the Nevada Test Site (NTS), Nye County, Nevada, in accordance with a 1987 DOE memorandum stating that all past, present, and future nuclear test sites would be treated as Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites (Memorandum from Bruce Green, Weapons Design and Testing Division, June 6, 1987). DOE has prepared an environmental assessment (DOE/EA-0532) to evaluate the environmental consequences associated with the proposed action, referred to as the Groundwater Characterization Project (GCP). This proposed action includes constructing access roads and drill pads, drilling and testing wells, and monitoring these wells for the purpose of characterizing groundwater at the NTS. Long-term monitoring and possible use of these wells in support of CERCLA, as amended by the Superfund Amendments and Reauthorization Act, is also proposed. The GCP includes measures to mitigate potential impacts on sensitive biological, cultural and historical resources, and to protect workers and the environment from exposure to any radioactive or mixed waste materials that may be encountered. DOE considers those mitigation measures related to sensitive biological, cultural and historic resources as essential to render the impacts of the proposed action not significant, and DOE has prepared a Mitigation Action Plan (MAP) that explains how such mitigations will be planned and implemented. Based on the analyses presented in the EA, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, preparation of an environmental impact statement is not required and the Department is issuing this FONSI.

  9. CONVIRT: a web-based tool for transcriptional regulatory site identification using a conserved virtual chromosome.

    Science.gov (United States)

    Ryu, Taewoo; Lee, Sejoon; Hur, Cheol Goo; Lee, Doheon

    2009-12-31

    Techniques for analyzing protein-DNA interactions on a genome-wide scale have recently established regulatory roles for distal enhancers. However, the large sizes of higher eukaryotic genomes have made identification of these elements difficult. Information regarding sequence conservation, exon annotation and repetitive regions can be used to reduce the size of the search region. However, previously developed resources are inadequate for consolidating such information. CONVIRT is a web resource for the identification of transcription factor binding sites and also features comparative genomics. Genomic information on ortholog-independent conserved regions, exons, repeats and sequences is integrated into the virtual chromosome, and statistically over-represented single or combinations of transcription factor binding sites are sought. CONVIRT provides regulatory network analysis for several organisms with long promoter regions and permits inter-species genome alignments. CONVIRT is freely available at http://biosoft.kaist. ac.kr/convirt.

  10. Social Network Sites as ESL/EFL Learning and Teaching Tools: A Critical Review

    Directory of Open Access Journals (Sweden)

    Sulaiman Alnujaidi

    2017-03-01

    Full Text Available This study analyzed the educational and instructional implications of Social Network Sites (SNS in the ESL/EFL teaching and learning context. SNS's definition, types, classifications, features, positive and negative aspects, their educational implications as well as their limitations and challenges in the ESL/EFL classroom settings are identified and discussed in order to better utilize and integrate their innovative aspects into the language teaching and learning practices.

  11. Radiologic characterization of the Mexican Hat, Utah, uranium mill tailings remedial action site: Addendum D1

    Energy Technology Data Exchange (ETDEWEB)

    Ludlam, J.R.

    1985-01-01

    This radiologic characterization of the inactive uranium millsite at Mexican Hat, Utah, was conducted by Bendix Field Engineering Corporation for the US Department of Energy (DOE), Grand Junctions Project Office in response to and in accord with a Statement of Work prepared by the DOE Uranium Mill Tailings Remedial Action Project (UMTRAP) Technical Assistance Contractor, Jacobs Engineering Group, Inc. The objective of this project was to determine the horizontal and vertical extent of contamination that exceeds the US Environmental Protection Agency (EPA) standards at the Mexican Hat site. The data presented in this report are required for characterization of the areas adjacent to the Mexican Hat tailings piles and for the subsequent design of cleanup activities. Some on- pile sampling was required to determine the depth of the 15-pCi/g Ra- 226 interface in an area where wind and water erosion has taken place.

  12. Site Characterization for the MBCE/DIRT II Battlefield Environment Tests

    Science.gov (United States)

    1981-09-01

    study was performed by Messrs. Carlos Lebron , Billy Helmuth, and Douglas Rockett under the tech- nical supervision of Mr. James B. Mason, Project...LEVEL;!;v *-" MISCELLANEOUS PAPER EL-81-B SITE CHARACTERIZATION FOR THE 00 MBCE/DIRT I! BATTLEFIELD ENVIRONMENT TESTS n by n James B. Mason and...GRANT NUMBER(e) James B./Mason Katherine S.gLong / 4S 1.a- -0 9. PERFORMING ORGANIZATION NAME AND ADDRESS ,0. PROGRAM ELEMENT. PROJECT. TASK U. S. Army

  13. Site characterization plan: Yucca Mountain Site, Nevada Research and Development Area, Nevada: Volume 2, Part A: Chapters 3, 4, and 5

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-12-01

    This site characterization plan (SCP) has been developed for the candidate repository site at Yucca Mountain in the State of Nevada. The SCP includes a description of the Yucca Mountain site (Chapters 1--5), a conceptual design for the repository (Chapter 6), a description of the packaging to be used for the waste to be emplaced in the repository (Chapter 7), and a description of the planned site characterization activities (Chapter 8). The schedules and milestones presented in Sections 8.3 and 8.5 of the SCP were developed to be consistent with the June 1988 draft Amendment to the DOE`s Mission Plan for the Civilian Radioactive Waste Management Program. The five month delay in the scheduled start of exploratory shaft construction that was announced recently is not reflected in these schedules. 575 refs., 84 figs., 68 tabs.

  14. Site characterization plan: Yucca Mountain Site, Nevada Research and Development Area, Nevada: Volume 4, Part B: Chapter 8, Sections 8.0 through 8.3.1.4

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-12-01

    This site characterization plan (SCP) has been developed for the candidate repository site at Yucca Mountain in the State of Nevada. The SCP includes a description of the Yucca Mountain site (Chapters 1-5), a conceptual design for the repository (Chapter 6), a description of the packaging to be used for the waste to be emplaced in the repository (Chapter 7), and a description of the planned site characterization activities (Chapter 8). The schedules and milestones presented in Sections 8.3 and 8.5 of the SCP were developed to be consistent with the June 1988 draft Amendment to the DOE`s Mission Plan for the Civilian Radioactive Waste Management Program. The five month delay in the scheduled start of exploratory shaft construction that was announced recently is not reflected in these schedules. 74 figs., 32 tabs.

  15. Calculating the radiological parameters used in non-human biota dose assessment tools using ERICA Tool and site-specific data

    Energy Technology Data Exchange (ETDEWEB)

    Sotiropoulou, Maria [INRASTES, NCSR ' ' Demokritos' ' , Environmental Radioactivity Laboratory, Athens (Greece); Aristotle University of Thessaloniki, Atomic and Nuclear Physics Laboratory, Thessaloniki (Greece); Florou, Heleny [INRASTES, NCSR ' ' Demokritos' ' , Environmental Radioactivity Laboratory, Athens (Greece); Kitis, Georgios [Aristotle University of Thessaloniki, Atomic and Nuclear Physics Laboratory, Thessaloniki (Greece)

    2017-11-15

    The substantial complexity in ecosystem-radionuclide interactions is difficult to be represented in terms of radiological doses. Thus, radiological dose assessment tools use typical exposure situations for generalized organisms and ecosystems. In the present study, site-specific data and radioactivity measurements of terrestrial organisms (grass and herbivore mammals) and abiotic components (soil) are provided. The retrieved data are used in combination with the ERICA Assessment Tool for calculation of radiological parameters. The process of radionuclide transfer within ecosystem components is represented using concentration ratios (CRs), while for the calculation of dose rates the dose conversion coefficient (DCC) methodology is applied. Comparative assessments are performed between the generic and assessment-specific radiological parameters and between the resulting dose rates. Significant differences were observed between CRs calculated in this study and those reported in the literature for cesium and thorium, which can easily be explained. On the other hand, CRs calculated for radium are in very good agreement with those reported in the literature. The DCCs exhibited some small differences between the reference and the assessment-specific organism due to mass differences. The differences were observed for internal and external dose rates, but they were less pronounced for total dose rates which are typically used in the assessment of radiological impact. The results of the current work can serve as a basis for further studies of the radiological parameters in environments that have not been studied yet. (orig.)

  16. Exploratory shaft facility: It`s role in the characterization of the Yucca Mountain site for a potential nuclear repository

    Energy Technology Data Exchange (ETDEWEB)

    Kalia, H.N.; Merson, T.J.

    1990-03-01

    The US Department of Energy is characterizing Yucca Mountain, Nevada, to assess its suitability as a potential site for the permanent disposal of high-level radioactive waste from nuclear power plants and defense related activities. The assessment activities include surface investigations, drill holes from the surface, and an underground facility for in situ characterization tests. This underground exploratory shaft facility is being designed to meet the criteria for characterizing the mountain as described in the Site Characterization Plan. 9 refs., 9 figs., 1 tab.

  17. Macrolithic tools for mining and primary processing of metal ores from the site of Grotta della Monaca (Calabria, Italy

    Directory of Open Access Journals (Sweden)

    Francesco Breglia

    2016-10-01

    In this paper we focus on two categories of macrolithic tools: those used to extract minerals, and those used for their primary processing. The first group is composed of 51 artefacts divided into axes, hammers, and pickaxes with a central groove, found in the deeper areas of the cave, which represent the mining areas. Their morphological and dimensional variability indicates a significant functional diversification; furthermore, the choice of different very hard metamorphic rocks implies a high awareness in the selection of the raw materials used for making these implements. The second group includes 22 tools with different functions - mainly made of sandstone - classified as querns, grinders and crushers. They were found in an underground area adjacent to the entrance, which is characterized by large and comfortable spaces, with the widespread presence of natural light. A recent traceological study has clarified the function of such artefacts; they were used to grind mined blocks of iron hydroxides to obtain a powder. The multidisciplinary approach adopted in studying mining tools from Grotta della Monaca, including petrographic, typological and use-wear analysis, has allowed us to gain important knowledge about the general characteristics of these tools.

  18. Site investigation as tool for elimination of natural hazard impact on construction project

    Science.gov (United States)

    Pospíšil, Pavel; Rozsypal, Alexandr

    2017-09-01

    Natural hazards and their impact on traffic structures represent the most risk factor during the construction phase and maintenance of traffic structure. The article deals with the process of site investigation focused on elimination of natural hazards impact on the structure. It is described the importance of gradual assessment especially of rock environment conditions in relation to specific traffic structure. Significant role plays cooperation between foundation designers and investigation workers especially for right classification of geotechnical category and final determination of characteristic values for documented rock formations. Positive and negative role of standardised approaches included in various standards are also.

  19. Social media and rating sites as tools to understanding quality of care: a scoping review.

    Science.gov (United States)

    Verhoef, Lise M; Van de Belt, Tom H; Engelen, Lucien J L P G; Schoonhoven, Lisette; Kool, Rudolf B

    2014-02-20

    Insight into the quality of health care is important for any stakeholder including patients, professionals, and governments. In light of a patient-centered approach, it is essential to assess the quality of health care from a patient's perspective, which is commonly done with surveys or focus groups. Unfortunately, these "traditional" methods have significant limitations that include social desirability bias, a time lag between experience and measurement, and difficulty reaching large groups of people. Information on social media could be of value to overcoming these limitations, since these new media are easy to use and are used by the majority of the population. Furthermore, an increasing number of people share health care experiences online or rate the quality of their health care provider on physician rating sites. The question is whether this information is relevant to determining or predicting the quality of health care. The goal of our research was to systematically analyze the relation between information shared on social media and quality of care. We performed a scoping review with the following goals: (1) to map the literature on the association between social media and quality of care, (2) to identify different mechanisms of this relationship, and (3) to determine a more detailed agenda for this relatively new research area. A recognized scoping review methodology was used. We developed a search strategy based on four themes: social media, patient experience, quality, and health care. Four online scientific databases were searched, articles were screened, and data extracted. Results related to the research question were described and categorized according to type of social media. Furthermore, national and international stakeholders were consulted throughout the study, to discuss and interpret results. Twenty-nine articles were included, of which 21 were concerned with health care rating sites. Several studies indicate a relationship between information

  20. Comparison of nest-site selection patterns of different sympatric raptor species as a tool for their conservation

    Directory of Open Access Journals (Sweden)

    Poirazidis, K.

    2007-12-01

    Full Text Available In this study the nest-site selection patterns of four tree-nesting sympatric raptor species in Dadia National Park (Greece were compared in order to provide a sound conservation tool for their long-term management in the area. The species studied were the Black vulture (Aegypius monachus, the Lesser-spotted eagle (Aquila pomarina, the Booted eagle (Hieraaetus pennatus and the Goshawk (Accipiter gentilis. Twenty-six variables illustrating the landscape context and vegetation structure of nesting sites were analysed. Multivariate-ANOVA and Discriminant Function Analysis were used to test for significant differentiations in nest-site characteristics among the species. The species studied were initially differentiated by geomorphology and distance to foraging areas. Once these were determined their nesting areas were established according to forest structure. Our results indicate that forest management should integrate the preservation of mature forest stands with sparse canopy and forest heterogeneity in order to conserve suitable nesting habitats for the raptors. Specific conservation measures such as restriction of road construction should be implemented in order to protect the active nests and provisions should be made for adequate nesting sites for the Black vulture, which is sensitive to human disturbance.

  1. Development of a Geographic Information System-Based Decision Support Tool for Evaluating Windfarm Sitings in Great Lakes Aquatic Habitats

    Energy Technology Data Exchange (ETDEWEB)

    Wehrly, Kevin E. [Michigan Dept. Natural Resources and Environment, Lansing, MI (United States); Rutherford, Edward S. [Great Lakes Environmental Research Lab., Ann Harbor, MI (United States); Wang, Lizhu [Michigan Dept. Natural Resources and Environment, Lansing, MI (United States); Breck, Jason [Univ. of Michigan, Ann Arbor, MI (United States). School of Natural Resources and Environment (UM-SNRE); Mason, Lacey [Univ. of Michigan, Ann Arbor, MI (United States). School of Natural Resources and Environment (UM-SNRE); Nelson, Scott [USGS Great Lakes Science Center, Ann Arbor, MI (United States)

    2011-07-31

    As an outcome of our research project, we developed software and data for the Lakebed Alteration Decision Support Tool (LADST), a web-based decision support program to assist resource managers in making siting decisions for offshore wind farms (as well as other lakebed-altering projects) in the United States' waters of the Great Lakes. Users of the LADST can create their own offshore wind farm suitability maps, based upon suitability criteria of their own choosing by visiting a public web site. The LADST can be used to represent the different priorities or values of different Great Lakes stakeholders for wind farm siting, as well as the different suitability requirements of wind farms (or different types of development projects) in a single suitability analysis system. The LADST makes this type of customized suitability analysis easily accessible to users who have no specialized software or experience with geographic information systems (GIS). It also may increase the transparency of the siting and permitting process for offshore wind farms, as it makes the suitability analysis equally accessible to resource managers, wind farm developers, and concerned citizens.

  2. Tools and methods for detecting and characterizing giardia, cryptosporidium, and toxoplasma parasites in marine mollusks.

    Science.gov (United States)

    Hohweyer, Jeanne; Dumètre, Aurélien; Aubert, Dominique; Azas, Nadine; Villena, Isabelle

    2013-09-01

    Foodborne infections are of public health importance and deeply impact the global economy. Consumption of bivalve mollusks generates risk for humans because these filtering aquatic invertebrates often concentrate microbial pathogens from their environment. Among them, Giardia, Cryptosporidium, and Toxoplasma are major parasites of humans and animals that may retain their infectivity in raw or undercooked mollusks. This review aims to detail current and future tools and methods for ascertaining the load and potential infectivity of these parasites in marine bivalve mollusks, including sampling strategies, parasite extraction procedures, and their characterization by using microscopy and/or molecular techniques. Method standardization should lead to better risk assessment of mollusks as a source of these major environmental parasitic pathogens and to the development of safety regulations, similar to those existing for bacterial and viral pathogens encountered in the same mollusk species.

  3. "Tools" for the Development of the Inspection Activity in Archaeological Sites

    Directory of Open Access Journals (Sweden)

    Susanna Bortolotto

    2015-05-01

    Full Text Available One of the acquisitions of contemporary conservation philosophy is precisely this: you don’t restore the image but the matter of the work; restoration is first and foremost the conservation of the work’s authenticity. The task of conservation is not returning to an impossible past but rather enabling the work to be handed down to the future. From this standpoint, in today’s conservation language we speak of conservation: guaranteeing through our efforts that the work entrusted to us will still be available for the future, for ourselves and the generations to come, eliminating or slowing down the causes of deterioration that endanger it so that it can be enjoyed and used. The project, "Milan Archaeology for Expo 2015. Towards a valorization of the archaeological heritage of the city", intends - respect to these theoretical and methodological - to develop processes of knowledge and planned conservation of urban archaeological areas with coordinated maintenance actions, promotion and communication of the different sites present in Milan historic centre. All this sites will be connected in a network system built for a larger project that it will increase the accessibility and enhancement.

  4. Multi-criteria assessment tool for sustainability appraisal of remediation alternatives for a contaminated site

    DEFF Research Database (Denmark)

    Søndergaard, Gitte Lemming; Binning, Philip John; Bondgård, Morten

    2017-01-01

    Purpose: In order to improve and support decision-making for the selection of remedial techniques for contaminated sites, a multi-criteria assessment (MCA) method has been developed. The MCA framework is structured in a decision process actively involving stakeholders, and compares the sustainabi......Purpose: In order to improve and support decision-making for the selection of remedial techniques for contaminated sites, a multi-criteria assessment (MCA) method has been developed. The MCA framework is structured in a decision process actively involving stakeholders, and compares...... the sustainability of remediation alternatives by integrating environmental, societal, and economic criteria in the assessment. Materials and methods: The MCA includes five main decision criteria: remedial effect, remediation cost, remediation time, environmental impacts, and societal impacts. The main criteria...... are divided into a number of sub-criteria. The environmental impacts consider secondary impacts to the environment caused by remedial activities and are assessed by life-cycle assessment (LCA). The societal impacts mainly consider local impacts and are assessed in a more qualitative manner on a scale from 1...

  5. Site characterization report for Building 3515 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    1994-08-01

    Building 3515 at Oak Ridge National Laboratory (ORNL), also known as the Fission Product Pilot Plant, is a surplus facility in the main plant area to the east of the South Tank Farm slated for decontamination and decommissioning (D&D). The building consists of two concrete cells (north and south) on a concrete pad and was used to extract radioisotopes of ruthenium, strontium, cesium, cerium, rhenium and other elements from aqueous fission product waste. Site characterization activities of the building were initiated. The objective of the site characterization was to provide information necessary for engineering evaluation and planning of D&D approaches, planning for personal protection of D&D workers, and estimating waste volumes from D&D activities. This site characterization report documents the investigation with a site description, a summary of characterization methods, chemical and radiological sample analysis results, field measurement results, and waste volume estimates.

  6. ECHO Project: a series of tools for studying and characterizing seismic sequences evolution

    Science.gov (United States)

    Falcone, Giuseppe; De Santis, Angelo; Di Giovambattista, Rita; Cianchini, Gianfranco; Murru, Maura; Calderoni, Giovanna; Lucente, Pio Francesco; De Gori, Pasquale; Frepoli, Alberto; Signanini, Patrizio; Rainone, Mario; Vessia, Giovanna

    2016-04-01

    One of the most ubiquitous problems in seismology is to discriminate between seismic sequences (a series of small-to-moderate earthquakes that culminate with a mainshock) and swarms (diffuse seismicity w/o mainshock), that can be easily done only after a certain class of earthquakes have occurred. We propose to put these phenomena under the same framework provided by the geosystemics (De Santis, 2009, 2014), where the planet Earth and its processes are seen from a holistic point of view, and the New Geophysics (Crampin et al., 2013), where fluid-saturated microcracks in almost all crustal rocks are so closely-spaced they verge on failure and hence are highly-compliant critical systems (Signanini and De Santis, 2012). In this context, nonlinear concepts typical of Chaos and Information theories are fundamental to study and characterize the various features of the series of seismic events, and, eventually, to discriminate between seismic sequences and swarms. The two theories imply the use of non-linear techniques which are innovative in seismology. The project ECHO ("Entropy and CHaOs: tools for studying and characterizing seismic sequences evolution"), a recent INGV-funded project, would aim at applying the above approaches in a more integrated way mainly to establish a suite of effective tools to disclose and characterise the principal features of the series of earthquakes which are of interest. In our view this will represent the very first step before to face the more challenging (but longer-term) problem of discriminating between the two kinds of series of seismic events. This poster will describe these kinds of preliminary activities and relative results in the framework of the project.

  7. Yucca Mountain Site Characterization Project bibliography, 1992--1994. Supplement 4

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-06-01

    Following a reorganization of the Office of Civilian Radioactive Waste Management in 1990, the Yucca Mountain Project was renamed Yucca Mountain Site Characterization Project. The title of this bibliography was also changed to Yucca Mountain Site Characterization Project Bibliography. Prior to August 5, 1988, this project was called the Nevada Nuclear Waste Storage Investigations. This bibliography contains information on this ongoing project that was added to the Department of Energy`s Energy Science and Technology Database from January 1, 1992, through December 31, 1993. The bibliography is categorized by principal project participating organization. Participant-sponsored subcontractor reports, papers, and articles are included in the sponsoring organization`s list. Another section contains information about publications on the Energy Science and Technology Database that were not sponsored by the project but have some relevance to it. Earlier information on this project can be found in the first bibliography DOE/TIC-3406, which covers 1977--1985, and its three supplements DOE/OSTI-3406(Suppl.1), DOE/OSTI-3406(Suppl.2), and DOE/OSTI-3406(Suppl.3), which cover information obtained during 1986--1987, 1988--1989, and 1990--1991, respectively. All entries in the bibliographies are searchable online on the NNW database file. This file can be accessed through the Integrated Technical Information System (ITIS) of the US Department of Energy (DOE).

  8. Structural characterization of nonactive site, TrkA-selective kinase inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Su, Hua-Poo; Rickert, Keith; Burlein, Christine; Narayan, Kartik; Bukhtiyarova, Marina; Hurzy, Danielle M.; Stump, Craig A.; Zhang, Xufang; Reid, John; Krasowska-Zoladek, Alicja; Tummala, Srivanya; Shipman, Jennifer M.; Kornienko, Maria; Lemaire, Peter A.; Krosky, Daniel; Heller, Amanda; Achab, Abdelghani; Chamberlin, Chad; Saradjian, Peter; Sauvagnat, Berengere; Yang, Xianshu; Ziebell, Michael R.; Nickbarg, Elliott; Sanders, John M.; Bilodeau, Mark T.; Carroll, Steven S.; Lumb, Kevin J.; Soisson, Stephen M.; Henze, Darrell A.; Cooke, Andrew J. (Merck)

    2016-12-30

    Current therapies for chronic pain can have insufficient efficacy and lead to side effects, necessitating research of novel targets against pain. Although originally identified as an oncogene, Tropomyosin-related kinase A (TrkA) is linked to pain and elevated levels of NGF (the ligand for TrkA) are associated with chronic pain. Antibodies that block TrkA interaction with its ligand, NGF, are in clinical trials for pain relief. Here, we describe the identification of TrkA-specific inhibitors and the structural basis for their selectivity over other Trk family kinases. The X-ray structures reveal a binding site outside the kinase active site that uses residues from the kinase domain and the juxtamembrane region. Three modes of binding with the juxtamembrane region are characterized through a series of ligand-bound complexes. The structures indicate a critical pharmacophore on the compounds that leads to the distinct binding modes. The mode of interaction can allow TrkA selectivity over TrkB and TrkC or promiscuous, pan-Trk inhibition. This finding highlights the difficulty in characterizing the structure-activity relationship of a chemical series in the absence of structural information because of substantial differences in the interacting residues. These structures illustrate the flexibility of binding to sequences outside of—but adjacent to—the kinase domain of TrkA. This knowledge allows development of compounds with specificity for TrkA or the family of Trk proteins.

  9. Site characterization of the Romanian Seismic Network stations: a national initiative and its first preliminary results

    Science.gov (United States)

    Grecu, Bogdan; Zahria, Bogdan; Manea, Elena; Neagoe, Cristian; Borleanu, Felix; Diaconescu, Mihai; Constantinescu, Eduard; Bala, Andrei

    2017-04-01

    The seismic activity in Romania is dominated by the intermediate-depth earthquakes occurring in Vrancea region, although weak to moderate crustal earthquakes are produced regularly in different areas of the country. The National Institute for Earth Physics (NIEP) built in the last years an impressive infrastructure for monitoring this activity, known as the Romanian Seismic Network (RSN). At present, RSN consists of 122 seismic stations, of which 70 have broadband velocity sensors and 42 short period sensors. One hundred and eleven stations out of 122 have accelerometer sensors collocated with velocity sensors and only 10 stations have only accelerometers. All the stations record continuously the ground motion and the data are transmitted in real-time to the Romanian National Data Center (RoNDC), in Magurele. Last year, NIEP has started a national project that addresses the characterization of all real-time seismic stations that constitute the RSN. We present here the steps that were undertaken and the preliminary results obtained since the beginning the project. The first two activities consisted of collecting all the existent technical and geological data, with emphasize on the latter. Then, we performed station noise investigations and analyses in order to characterize the noise level and estimate the resonances of the sites. The computed H/V ratios showed clear resonant peaks at different frequencies which correlate relatively well with the thickness of the sedimentary package beneath the stations. The polarization analysis of the H/V ratios indicates for some stations a strong directivity of the resonance peak which suggests possible topographic effects at the stations. At the same time, special attention was given to the estimation of the site amplification from earthquake data. The spectral ratios obtained from the analysis of more than 50 earthquakes with magnitudes (Mw) larger than 4.1 are characterized by similar resonance peaks as those obtained from

  10. Pharmacological characterization of intracellular, membrane, and plasma binding sites for corticosterone in house sparrows.

    Science.gov (United States)

    Breuner, Creagh W; Orchinik, Miles

    2009-09-01

    The diversity and specificity of glucocorticoid effects are dependent on cell-specific receptor mechanisms. Three known corticosteroid receptors mediate tissue effects of glucocorticoids in vertebrates: two intracellular receptors that act primarily as ligand-activated transcription factors, and a membrane-associated receptor. The intracellular receptor sub-types have been well characterized in mammals, however relatively little is known about them across non-mammalian vertebrates. The membrane-associated receptors are poorly characterized in most vertebrate taxa. To explore the basis for glucocorticoid action in birds, we pharmacologically characterized the three putative corticosteroid receptors in the brain, as well as a plasma corticosterone binding globulin, in the house sparrow (Passer domesticus). We found that house sparrow brain cytosol contained two distinguishable binding sites for corticosterone. A high affinity, mineralocorticoid-like receptor had subnanomolar affinity for corticosterone (K(d) approximately 0.2 nM). However, this 'MR-like' high-affinity receptor did not bind RU28318 or canrenoic acid, two compounds that bind mammalian MR with high affinity. A lower-affinity, glucocorticoid-like receptor in brain cytosol bound corticosterone with an average K(d)=5.61 nM. This GR-like receptor showed subnanomolar affinity for RU 486. MR- and GR-like receptors were found in equal numbers in whole brain assays (average B(max)=69 and 62 fmol/mg protein, respectively). House sparrow brain membranes contain a single binding site specific for glucocorticoids, with characteristics consistent with a steroid/receptor interaction. Corticosterone affinity for this putative membrane receptor was approximately 24 nM, with apparent B(max)=177 fmol/mg protein. House sparrow plasma contained a single binding site for [(3)H]corticosterone. Specific binding to plasma sites was inhibited by glucocorticoids, progesterone, and testosterone. Testosterone binding to this

  11. Development of enabling scientific tools to characterize the geologic subsurface at Hanford

    Science.gov (United States)

    Kenna, T. C.; Herron, M.; Ward, A. L.

    2010-12-01

    Petrophysical models that relate borehole neutron and gamma ray data to reservoir properties including clay content, porosity, permeability, and water saturation have been successfully employed in the petroleum industry, but remain relatively undeveloped in the area of subsurface remediation. The objectives of this research are to: 1) Analyze core and outcrop samples from representative facies for a variety of mineralogical, chemical and physical properties 2) Predict the response of a variety of neutron and gamma logging tools based on these measurements 3) Develop algorithms to translate log responses into reservoir properties useful for input in flow and reactive transport models Initial work performed on eleven samples from Hanford well 399-3-18 (C4999), located near the Hanford 300 Area Integrated Field Research Challenge (IFRC) site, indicates a significant correlation between core gamma ray data and total clay as determined by Dual Range Fourier Transform Infrared spectroscopy. The core gamma ray data permit calibration of the existing gamma ray logs, hundreds which already exist at Hanford, into standard API units and then into total clay as a function of depth. The algorithms being developed are applicable to archived borehole logs as well as to more complete suites of logs collected more recently and will therefore lead to improved interpretations. It is anticipated that this research will provide guidance in selecting the most appropriate logs to run in future logging programs depending on the desired properties and the uncertainty of the estimate. In addition it will improve our ability to remotely define subsurface petrophysical and flow properties, a pre-requisite for understanding subsurface processes and deigning effective remedial strategies. Although the focus of this study is on a single site, the approach may serve as a template for application at other sites where DOE has remediation responsibilities and stewardship challenges.

  12. Site characterization progress report: Yucca Mountain, Nevada, April 1, 1992--September 30, 1992, Number 7

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-12-01

    In accordance with section 113(b)(3) of the Nuclear Waste Policy Act of 1982, as amended (NWPA), the Department has prepared the seventh in a series of reports on the progress of site characterization at the Yucca Mountain candidate site. The Civilian Radioactive Waste Management Program made significant progress during the reporting period at the Yucca Mountain Site Characterization Project. Several important advances were made in the surface-based testing program including: initiation of borehole drilling utilizing the new, state-of-the-art LM-300 drill rig which employs dry drilling and coring techniques; neutron access borehole drilling to evaluate infiltration processes; excavations to aid geologic mapping; and trenching in Midway Valley to study Quaternary faulting. A Floodplain Assessment and Statement of Findings was published in the Federal Register which concluded there would be no significant impact nor cumulative impacts on floodplains resulting from Exploratory Studies Facility activities. The National Academy of Sciences` National Research Council released its report entitled ``Ground Water at Yucca Mountain: How High Can It Rise?`` which concluded that none of the evidence cited as proof of groundwater upwelling in and around Yucca Mountain could be reasonably attributed to that process and that significant water table excursions to the repository design level are not shown by the geologic record. The June 29, 1992, earthquake near Yucca Mountain provided scientists with a wealth of information relevant to understanding the neotectonics of the area and the geometry of faults at depth. Early findings suggest that accelerations recorded were well within proposed design limits for the surface waste handling facilities.

  13. Social Media and Rating Sites as Tools to Understanding Quality of Care: A Scoping Review

    Science.gov (United States)

    Van de Belt, Tom H; Engelen, Lucien JLPG; Schoonhoven, Lisette; Kool, Rudolf B

    2014-01-01

    Background Insight into the quality of health care is important for any stakeholder including patients, professionals, and governments. In light of a patient-centered approach, it is essential to assess the quality of health care from a patient’s perspective, which is commonly done with surveys or focus groups. Unfortunately, these “traditional” methods have significant limitations that include social desirability bias, a time lag between experience and measurement, and difficulty reaching large groups of people. Information on social media could be of value to overcoming these limitations, since these new media are easy to use and are used by the majority of the population. Furthermore, an increasing number of people share health care experiences online or rate the quality of their health care provider on physician rating sites. The question is whether this information is relevant to determining or predicting the quality of health care. Objective The goal of our research was to systematically analyze the relation between information shared on social media and quality of care. Methods We performed a scoping review with the following goals: (1) to map the literature on the association between social media and quality of care, (2) to identify different mechanisms of this relationship, and (3) to determine a more detailed agenda for this relatively new research area. A recognized scoping review methodology was used. We developed a search strategy based on four themes: social media, patient experience, quality, and health care. Four online scientific databases were searched, articles were screened, and data extracted. Results related to the research question were described and categorized according to type of social media. Furthermore, national and international stakeholders were consulted throughout the study, to discuss and interpret results. Results Twenty-nine articles were included, of which 21 were concerned with health care rating sites. Several studies

  14. Technical data base quarterly report, April--June 1992; Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-09-01

    The acquisition and development of technical data are activities that provide the information base from which the Yucca mountain Site will be characterized and may P-ventually be licensed as a high-level waste repository. The Project Technical Data Base (TDB) is the repository for the regional and site-specific technical data required in intermediate and license application analyses and models. The TDB Quarterly Report provides the mechanism for identifying technical data currently available from the Project TDB. Due to the variety of scientific information generated by YMP activities, the Project TDB consists of three components, each designed to store specific types of data. The Site and Engineering Properties Data Base (SEPDB) maintains technical data best stored in a tabular format. The Geographic Nodal Information Study and Evaluation System (GENISES), which is the Geographic Information System (GIS) component of the Project TDB, maintains spatial or map-like data. The Geologic and Engineering Materials Bibliography of Chemical Species (GEMBOCHS) data base maintains thermodynamic/geochemical data needed to support geochemical reaction models involving the waste package and repository geochemical environment. Each of these data bases are addressed independently within the TDB Quarterly Report.

  15. Absolute gravity measurements at three sites characterized by different environmental conditions using two portable ballistic gravimeters

    Science.gov (United States)

    Greco, Filippo; Biolcati, Emanuele; Pistorio, Antonio; D'Agostino, Giancarlo; Germak, Alessandro; Origlia, Claudio; Del Negro, Ciro

    2015-03-01

    The performances of two absolute gravimeters at three different sites in Italy between 2009 and 2011 is presented. The measurements of the gravity acceleration g were performed using the absolute gravimeters Micro-g LaCoste FG5#238 and the INRiM prototype IMGC-02, which represent the state of the art in ballistic gravimeter technology (relative uncertainty of a few parts in 109). For the comparison, the measured g values were reported at the same height by means of the vertical gravity gradient estimated at each site with relative gravimeters. The consistency and reliability of the gravity observations, as well as the performance and efficiency of the instruments, were assessed by measurements made in sites characterized by different logistics and environmental conditions. Furthermore, the various factors affecting the measurements and their uncertainty were thoroughly investigated. The measurements showed good agreement, with the minimum and maximum differences being 4.0 and 8.3 μGal. The normalized errors are very much lower than 1, ranging between 0.06 and 0.45, confirming the compatibility between the results. This excellent agreement can be attributed to several factors, including the good working order of gravimeters and the correct setup and use of the instruments in different conditions. These results can contribute to the standardization of absolute gravity surveys largely for applications in geophysics, volcanology and other branches of geosciences, allowing achieving a good trade-off between uncertainty and efficiency of gravity measurements.

  16. Social networking sites: emerging and essential tools for communication in dermatology.

    Science.gov (United States)

    Amir, Mahsa; Sampson, Blake P; Endly, Dawnielle; Tamai, Jennifer M; Henley, Jill; Brewer, Ann Chang; Dunn, Jeffrey H; Dunnick, Cory A; Dellavalle, Robert P

    2014-01-01

    The use of social media by dermatology journals and professional and patient-centered dermatology organizations remains largely unknown and, to our knowledge, has yet to be fully evaluated. To evaluate and quantify the extent of involvement of dermatology journals, professional dermatology organizations, and dermatology-related patient advocate groups on social networking sites. We obtained an archived list of 102 current dermatology journals from SCImago on the World Wide Web and used the list to investigate Facebook, Twitter, and individual journal websites for the presence of social media accounts. We identified professional and patient-centered dermatology organization activity on social networks through queries of predetermined search terms on Google, Facebook, Twitter, and LinkedIn. The activity of each entity was documented by recording the following metrics of popularity: the numbers of Facebook "likes," Twitter "followers," and LinkedIn "members." The numbers of Facebook likes, Twitter followers, and LinkedIn members corresponding to each dermatology journal and each professional and patient-related dermatology organization. On July 17, 2012, of the 102 dermatology journals ranked by SCImago, 12.7% were present on Facebook and 13.7% on Twitter. We identified popular dermatology journals based on Facebook likes and Twitter followers, led by the Journal of the American Academy of Dermatology and Dermatology Times, respectively. Popular professional dermatology organizations included dermRounds Dermatology Network (11 251 likes on Facebook and 2900 followers on Twitter). The most popular dermatology patient-centered organizations were the Skin Cancer Foundation (20 119 likes on Facebook), DermaTalk (21 542 followers on Twitter), and the National Psoriasis Foundation (200 members on LinkedIn). Patient-centered and professional dermatology organizations use social networking sites; however, academic journals tend to lag behind significantly. Although some

  17. Phenotype Microarrays as a complementary tool to next generation sequencing for characterization of tree endophytes

    Directory of Open Access Journals (Sweden)

    Kathrin eBlumenstein

    2015-09-01

    Full Text Available There is an increasing need to calibrate microbial community profiles obtained through next generation sequencing (NGS with relevant taxonomic identities of the microbes, and to further associate these identities with phenotypic attributes. Phenotype Microarray (PM techniques provide a semi-high throughput assay for characterization and monitoring the microbial cellular phenotypes. Here, we present detailed descriptions of two different PM protocols used in our recent studies on fungal endophytes of forest trees, and highlight the benefits and limitations of this technique. We found that the PM approach enables effective screening of substrate utilization by endophytes. However, the technical limitations are multifaceted and the interpretation of the PM data challenging. For the best result, we recommend that the growth conditions for the fungi are carefully standardized. In addition, rigorous replication and control strategies should be employed whether using pre-configured, commercial microwell-plates or in-house designed PM plates for targeted substrate analyses. With these precautions, the PM technique is a valuable tool to characterize the metabolic capabilities of individual endophyte isolates, or successional endophyte communities identified by NGS, allowing a functional interpretation of the taxonomic data. Thus, PM approaches can provide valuable complementary information for NGS studies of fungal endophytes in forest trees.

  18. Soft x rays as a tool to investigate radiation-sensitive sites in mammalian cells

    Energy Technology Data Exchange (ETDEWEB)

    Brenner, D.J.; Zaider, M.

    1983-01-01

    It is now clear that the initial geometrical distribution of primary radiation products in irradiated biological matter is fundamental to the observed end point (cell killing, mutation induction, chromosome aberrations, etc.). In recent years much evidence has accumulated indicating that for all radiations, physical quantities averaged over cellular dimensions (micrometers) are not good predictors of biological effect, and that energy-deposition processes at the nanometer level are critical. Thus irradiation of cells with soft x rays whose secondary electrons have ranges of the order of nanometers is a unique tool for investigating different models for predicting the biological effects of radiation. We demonstrate techniques whereby the biological response of the cell and the physical details of the energy deposition processes may be separated or factorized, so that given the response of a cellular system to, say, soft x rays, the response of the cell to any other radiation may be predicted. The special advantages of soft x rays for eliciting this information and also information concerning the geometry of the radiation sensitive structures within the cell are discussed.

  19. Site characterization in central Italy: the case of the Amatrice (IT.AMT) accelerometric station

    Science.gov (United States)

    Gaudiosi, Iolanda; Vignaroli, Gianluca; Pacor, Francesca; Bordoni, Paola; Mancini, Marco; Moscatelli, Massimiliano; Milana, Giuliano; GeoRAN-INGV working Group

    2017-04-01

    GeoRAN - INGV working group: G. P. Cavinato, G. Cosentino, S. Giallini, F. Polpetta, R. Razzano, M. Simionato, P. Sirianni (1); S. Amoroso, A. Bucci, E. D'Alema, M. D'Amico, F. Cara, S. Carannante, R. Cogliano, G. Cultrera, G. Di Giulio, D. Di Naccio, D. Famiani, C. Felicetta, A. Fodarella, G. Franceschina, G. Lanzano, S. Lovati, L. Luzi, C. Mascandola, M. Massa, A. Mercuri, D. Picaredda, M. Pischiutta, S. Pucillo, R. Puglia, G. Riccio, M. Vassallo (2) During the Mw 6.0 Amatrice earthquake, which struck Central Italy on the 24th August 2016, the accelerometric station AMT, located at about 10km from the epicentre recorded the highest values of the ground motion (Peak Ground Acceleration of the east component reached 0.87 g). To understand the role played by the site effects in the ground motion observed at AMT, we performed a detailed geological - geotechnical characterization of the site. First, geological field investigations were carried out and used to define a detailed geological cross-section intercepting AMT station. Then, aiming at constraining the Vs model, a continuous coring borehole was drilled close to the AMT site and a down-hole test was consequently executed in order to define the shear-wave velocity profile. In addition, MASW and several noise measurements were realized for better constraining the model and evaluating any eventual geological variability along the cross-section. Finally, numerical analyses of seismic site response were carried out using both 1D and 2D approaches including linear equivalent models. In parallel, several analysis were also performed on seismic records, to infer empirical amplification functions, used to compare the results of the numerical simulations This study was partially supported by the Italian Department of Civil Protection (DPC) of the Presidency of Council of Ministers. The INGV-CNR IGAG collaboration made possible the realization of this multidisciplinary study, which includes detailed seismological

  20. Geological site characterization for the proposed Mixed Waste Disposal Facility, Los Alamos National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Reneau, S.L.; Raymond, R. Jr. [eds.

    1995-12-01

    This report presents the results of geological site characterization studies conducted from 1992 to 1994 on Pajarito Mesa for a proposed Los Alamos National Laboratory Mixed Waste Disposal Facility (MWDF). The MWDF is being designed to receive mixed waste (waste containing both hazardous and radioactive components) generated during Environmental Restoration Project cleanup activities at Los Alamos. As of 1995, there is no Resource Conservation and Recovery Act (RCRA) permitted disposal site for mixed waste at the Laboratory, and construction of the MWDF would provide an alternative to transport of this material to an off-site location. A 2.5 km long part of Pajarito Mesa was originally considered for the MWDF, extending from an elevation of about 2150 to 2225 m (7060 to 7300 ft) in Technical Areas (TAs) 15, 36, and 67 in the central part of the Laboratory, and planning was later concentrated on the western area in TA-67. The mesa top lies about 60 to 75 m (200 to 250 ft) above the floor of Pajarito Canyon on the north, and about 30 m (100 ft) above the floor of Threemile Canyon on the south. The main aquifer used as a water supply for the Laboratory and for Los Alamos County lies at an estimated depth of about 335 m (1100 ft) below the mesa. The chapters of this report focus on surface and near-surface geological studies that provide a basic framework for siting of the MWDF and for conducting future performance assessments, including fulfillment of specific regulatory requirements. This work includes detailed studies of the stratigraphy, mineralogy, and chemistry of the bedrock at Pajarito Mesa by Broxton and others, studies of the geological structure and of mesa-top soils and surficial deposits by Reneau and others, geologic mapping and studies of fracture characteristics by Vaniman and Chipera, and studies of potential landsliding and rockfall along the mesa-edge by Reneau.

  1. Characterization of joining sites of a viral histone H4 on host insect chromosomes.

    Directory of Open Access Journals (Sweden)

    Sunil Kumar

    Full Text Available A viral histone H4 (CpBV-H4 is encoded in a polydnavirus, Cotesia plutellae bracovirus (CpBV. It plays a crucial role in parasitism of an endoparasitoid wasp, C. plutellae, against diamondback moth, Plutella xylostella, by altering host gene expression in an epigenetic mode by its N-terminal tail after joining host nucleosomes. Comparative transcriptomic analysis between parasitized and nonparasitized P. xylostella by RNA-Seq indicated that 1,858 genes were altered at more than two folds in expression levels at late parasitic stage, including 877 up-regulated genes and 981 down-regulated genes. Among parasitic factors altering host gene expression, CpBV-H4 alone explained 16.3% of these expressional changes. To characterize the joining sites of CpBV-H4 on host chromosomes, ChIP-Seq (chromatin immunoprecipitation followed by deep sequencing was applied to chromatins extracted from parasitized larvae. It identified specific 538 ChIP targets. Joining sites were rich (60.2% in AT sequence. Almost 40% of ChIP targets included short nucleotide repeat sequences presumably recognizable by transcriptional factors and chromatin remodeling factors. To further validate these CpBV-H4 targets, CpBV-H4 was transiently expressed in nonparasitized host at late larval stage and subjected to ChIP-Seq. Two kinds of ChIP-Seqs shared 51 core joining sites. Common targets were close (within 1 kb to genes regulated at expression levels by CpBV-H4. However, other host genes not close to CpBV-H4 joining sites were also regulated by CpBV-H4. These results indicate that CpBV-H4 joins specific chromatin regions of P. xylostella and controls about one sixth of the total host genes that were regulated by C. plutellae parasitism in an epigenetic mode.

  2. Preliminary site characterization summary and engineering evaluation/cost analysis for Site 2, New Fuel Farm, Naval Air Station Fallon, Fallon, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Cronk, T.A.; Smuin, D.R. (Oak Ridge National Lab., TN (United States)); Schlosser, R.M. (Oak Ridge Associated Universities, Inc., TN (United States))

    1991-09-01

    This report addresses subsurface contamination associated with Site 2, the New Fuel Farm at Naval Air Station Fallon (NAS Fallon), Nevada and is an integral part of Phase 2 of the Installation Restoration Program (IR Program) currently underway at the facility. This report: (1) reviews and assesses environmental information characterizing Site 2; (2) determine if site-characterization information is sufficient to design and evaluate removal actions; and, (3) investigates, develops, and describes any removal actions deemed feasible. Previous environmental investigations at Site 2 indicate the presence of floating product (primarily JP-5, jet fuel) on the water table underlying the facility. While the extent of floating-produce plumes has been characterized, the degree of associated soil and groundwater contamination remains uncertain. A comprehensive characterization of soil and groundwater contamination will be completed as the Remedial Investigation/Feasibility Study progresses. Corrective actions are recommended at this time to remove free-phase floating product. Implementing these removal actions will also provide additional information which will be used to direct further investigations of the extent, mobility, and potential environmental threat from soil and groundwater contaminants at this side.

  3. Characterization of Microbial Communities in Subsurface Nuclear Blast Cavities of the Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Moser, Duane; Russell, Chuck; Marshall, Matthew; Czerwinski, Ken; Daly, Michael J; Zavarin, Mavrik

    2008-02-08

    This exploratory research project is designed to test fundamental hypotheses concerning the possible existence and nature of indigenous microbial populations in Nevada Test Site (NTS) subsurface nuclear blast cavities. Although subsurface microbiological studies have been performed at the NTS in the past, radioactive zones have yet to be addressed. Nuclear blast zone microbiology is a completely new field and our team is well-positioned to collect and analyze samples that have never before been available to microbiologists. Relevant samples are now being obtained by incorporating microbiological collections into an ongoing annual hot well sampling program being conducted by other agencies. A combination of cultivation-based and molecular microbial detection protocols is being utilized at multiple locations to survey for uncultivable microorganisms and to develop a culture collection which will be characterized for radionuclide- and metal-reduction capabilities. Given that redox manipulations mediated by microorganisms can impact the mobility of DOE contaminants, a positive outcome from this work would have significant implications for management strategies at this and other DOE sites. A primary objective of the project has been the establishment of the regulatory and technical framework necessary to enable our acquisition of samples. Thus, much of our activity in the first phase of this work has involved the development an approved Field Area Work Plan (FAWP), Radiological Work Permit (RWP), and other documentation required for radiological work at the NTS. We have also invested significant time into ensuring that all personnel possess the required training (e.g. Radworker II and 40 hr. HAZWOPER) for access to the hot well sampling sites. Laboratory facilities, required for field processing of radioactive samples as well as DNA extraction and other manipulations, have been secured both the NTS (Mercury, NV) and UNLV. Although our year-1 field work was delayed due

  4. MDC-Analyzer: a novel degenerate primer design tool for the construction of intelligent mutagenesis libraries with contiguous sites.

    Science.gov (United States)

    Tang, Lixia; Wang, Xiong; Ru, Beibei; Sun, Hengfei; Huang, Jian; Gao, Hui

    2014-06-01

    Recent computational and bioinformatics advances have enabled the efficient creation of novel biocatalysts by reducing amino acid variability at hot spot regions. To further expand the utility of this strategy, we present here a tool called Multi-site Degenerate Codon Analyzer (MDC-Analyzer) for the automated design of intelligent mutagenesis libraries that can completely cover user-defined randomized sequences, especially when multiple contiguous and/or adjacent sites are targeted. By initially defining an objective function, the possible optimal degenerate PCR primer profiles could be automatically explored using the heuristic approach of Greedy Best-First-Search. Compared to the previously developed DC-Analyzer, MDC-Analyzer allows for the existence of a small amount of undesired sequences as a tradeoff between the number of degenerate primers and the encoded library size while still providing all the benefits of DC-Analyzer with the ability to randomize multiple contiguous sites. MDC-Analyzer was validated using a series of randomly generated mutation schemes and experimental case studies on the evolution of halohydrin dehalogenase, which proved that the MDC methodology is more efficient than other methods and is particularly well-suited to exploring the sequence space of proteins using data-driven protein engineering strategies.

  5. A Fiber-Optic Borehole Seismic Vector Sensor System for Geothermal Site Characterization and Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Paulsson, Bjorn N.P. [Paulsson, Inc., Van Nuys, CA (United States); Thornburg, Jon A. [Paulsson, Inc., Van Nuys, CA (United States); He, Ruiqing [Paulsson, Inc., Van Nuys, CA (United States)

    2015-04-21

    Seismic techniques are the dominant geophysical techniques for the characterization of subsurface structures and stratigraphy. The seismic techniques also dominate the monitoring and mapping of reservoir injection and production processes. Borehole seismology, of all the seismic techniques, despite its current shortcomings, has been shown to provide the highest resolution characterization and most precise monitoring results because it generates higher signal to noise ratio and higher frequency data than surface seismic techniques. The operational environments for borehole seismic instruments are however much more demanding than for surface seismic instruments making both the instruments and the installation much more expensive. The current state-of-the-art borehole seismic instruments have not been robust enough for long term monitoring compounding the problems with expensive instruments and installations. Furthermore, they have also not been able to record the large bandwidth data available in boreholes or having the sensitivity allowing them to record small high frequency micro seismic events with high vector fidelity. To reliably achieve high resolution characterization and long term monitoring of Enhanced Geothermal Systems (EGS) sites a new generation of borehole seismic instruments must therefore be developed and deployed. To address the critical site characterization and monitoring needs for EGS programs, US Department of Energy (DOE) funded Paulsson, Inc. in 2010 to develop a fiber optic based ultra-large bandwidth clamped borehole seismic vector array capable of deploying up to one thousand 3C sensor pods suitable for deployment into ultra-high temperature and high pressure boreholes. Tests of the fiber optic seismic vector sensors developed on the DOE funding have shown that the new borehole seismic sensor technology is capable of generating outstanding high vector fidelity data with extremely large bandwidth: 0.01 – 6,000 Hz. Field tests have shown

  6. Landform characterization using geophysics—Recent advances, applications, and emerging tools

    Science.gov (United States)

    Van Dam, Remke L.

    2012-01-01

    This paper presents an overview of the strengths and limitations of existing and emerging geophysical tools for landform studies. The objectives are to discuss recent technical developments and to provide a review of relevant recent literature, with a focus on propagating field methods with terrestrial applications. For various methods in this category, including ground-penetrating radar (GPR), electrical resistivity (ER), seismics, and electromagnetic (EM) induction, the technical backgrounds are introduced, followed by section on novel developments relevant to landform characterization. For several decades, GPR has been popular for characterization of the shallow subsurface and in particular sedimentary systems. Novel developments in GPR include the use of multi-offset systems to improve signal-to-noise ratios and data collection efficiency, amongst others, and the increased use of 3D data. Multi-electrode ER systems have become popular in recent years as they allow for relatively fast and detailed mapping. Novel developments include time-lapse monitoring of dynamic processes as well as the use of capacitively-coupled systems for fast, non-invasive surveys. EM induction methods are especially popular for fast mapping of spatial variation, but can also be used to obtain information on the vertical variation in subsurface electrical conductivity. In recent years several examples of the use of plane wave EM for characterization of landforms have been published. Seismic methods for landform characterization include seismic reflection and refraction techniques and the use of surface waves. A recent development is the use of passive sensing approaches. The use of multiple geophysical methods, which can benefit from the sensitivity to different subsurface parameters, is becoming more common. Strategies for coupled and joint inversion of complementary datasets will, once more widely available, benefit the geophysical study of landforms. Three cases studies are presented

  7. Investigating the tool marks on oracle bones inscriptions from the Yinxu site (ca., 1319-1046 BC), Henan province, China.

    Science.gov (United States)

    Zhao, Xiaolong; Tang, Jigen; Gu, Zhou; Shi, Jilong; Yang, Yimin; Wang, Changsui

    2016-09-01

    Oracle Bone Inscriptions in the Shang dynasty (1600-1046 BC) are the earliest well-developed writing forms of the Chinese character system, and their carving techniques have not been studied by tool marks analysis with microscopy. In this study, a digital microscope with three-dimensional surface reconstruction based on extended depth of focus technology was used to investigate tool marks on the surface of four pieces of oracle bones excavated at the eastern area of Huayuanzhuang, Yinxu site(ca., 1319-1046 BC), the last capital of the Shang dynasty, Henan province, China. The results show that there were two procedures to carve the characters on the analyzed tortoise shells. The first procedure was direct carving. The second was "outlining design," which means to engrave a formal character after engraving a draft with a pointed tool. Most of the strokes developed by an engraver do not overlap the smaller draft, which implies that the outlining design would be a sound way to avoid errors such as wrong and missing characters. The strokes of these characters have different shape at two ends and variations on width and depth of the grooves. Moreover, the bottom of the grooves is always rugged. Thus, the use of rotary wheel-cutting tools could be ruled out. In most cases, the starting points of the strokes are round or flat while the finishing points are always pointed. Moreover, the strokes should be engraved from top to bottom. When vertical or horizontal strokes had been engraved, the shell would be turned about 90 degrees to engrave the crossed strokes from top to bottom. There was no preferred order to engrave vertical or horizontal strokes. Since both sides of the grooves of the characters are neat and there exists no unorganized tool marks, then it is suggested that some sharp tools had been used for engraving characters on the shells. Microsc. Res. Tech. 79:827-832, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  8. Site characterization plan for groundwater in Waste Area Grouping 1 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    Lee, R.R.; Curtis, A.H.; Houlberg, L.M.; Purucker, S.T.; Singer, M.L.; Tardiff, M.F.; Wolf, D.A.

    1994-07-01

    The Waste Area Grouping (WAG) 1 Groundwater Operable Unit (OU) at Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee, is undergoing a site characterization to identify environmental contamination that may be present. This document, Site Characterization Report for Groundwater in Waste Area Grouping I at Oak Ridge National Laboratory, Oak Ridge, Tennessee, identifies areas of concern with respect to WAG 1 groundwater and presents the rationale, justification, and objectives for conducting this continuing site characterization. This report summarizes the operations that have taken place at each of the areas of concern in WAG 1, summarizes previous characterization studies that have been performed, presents interpretations of previously collected data and information, identifies contaminants of concern, and presents an action plan for further site investigations and early actions that will lead to identification of contaminant sources, their major groundwater pathways, and reduced off-site migration of contaminated groundwater to surface water. Site characterization Activities performed to date at WAG I have indicated that groundwater contamination, principally radiological contamination, is widespread. An extensive network of underground pipelines and utilities have contributed to the dispersal of contaminants to an unknown extent. The general absence of radiological contamination in surface water at the perimeter of WAG 1 is attributed to the presence of pipelines and underground waste storage tank sumps and dry wells distributed throughout WAG 1 which remove more than about 40 million gal of contaminated groundwater per year.

  9. Information needs for characterization of high-level waste repository sites in six geologic media. Volume 1. Main report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1985-05-01

    Evaluation of the geologic isolation of radioactive materials from the biosphere requires an intimate knowledge of site geologic conditions, which is gained through precharacterization and site characterization studies. This report presents the results of an intensive literature review, analysis and compilation to delineate the information needs, applicable techniques and evaluation criteria for programs to adequately characterize a site in six geologic media. These media, in order of presentation, are: granite, shale, basalt, tuff, bedded salt and dome salt. Guidelines are presented to assess the efficacy (application, effectiveness, and resolution) of currently used exploratory and testing techniques for precharacterization or characterization of a site. These guidelines include the reliability, accuracy and resolution of techniques deemed acceptable, as well as cost estimates of various field and laboratory techniques used to obtain the necessary information. Guidelines presented do not assess the relative suitability of media. 351 refs., 10 figs., 31 tabs.

  10. Wild plants as tools for the remediation of abandoned mining sites with a high arsenic content

    Science.gov (United States)

    Martínez-Lopez, Salvadora; Martínez-Sanchez, MJose; Perez-Sirvent, Carmen; Martínez, Lucia B.; Bech, Jaume

    2014-05-01

    species has been evaluated. The exposure pathway considered has been oral ingestion, calculating the contribution of the plant to the daily dose based on the arsenic concentration in the leaves of the plants analyzed. The Bioconcentration Factors are generally very low, the transfer Factors being somewhat higher although rarely exceed the unity. When dealing with phytoremediation of contaminated sites, the contribution of the As level in plants to the daily diet of animals should be used as an indicator for a suitable selection of the vegetal species to be used.

  11. Atomistic characterization of the active-site solvation dynamics of a model photocatalyst

    Science.gov (United States)

    van Driel, Tim B.; Kjær, Kasper S.; Hartsock, Robert W.; Dohn, Asmus O.; Harlang, Tobias; Chollet, Matthieu; Christensen, Morten; Gawelda, Wojciech; Henriksen, Niels E.; Kim, Jong Goo; Haldrup, Kristoffer; Kim, Kyung Hwan; Ihee, Hyotcherl; Kim, Jeongho; Lemke, Henrik; Sun, Zheng; Sundström, Villy; Zhang, Wenkai; Zhu, Diling; Møller, Klaus B.; Nielsen, Martin M.; Gaffney, Kelly J.

    2016-11-01

    The interactions between the reactive excited state of molecular photocatalysts and surrounding solvent dictate reaction mechanisms and pathways, but are not readily accessible to conventional optical spectroscopic techniques. Here we report an investigation of the structural and solvation dynamics following excitation of a model photocatalytic molecular system [Ir2(dimen)4]2+, where dimen is para-diisocyanomenthane. The time-dependent structural changes in this model photocatalyst, as well as the changes in the solvation shell structure, have been measured with ultrafast diffuse X-ray scattering and simulated with Born-Oppenheimer Molecular Dynamics. Both methods provide direct access to the solute-solvent pair distribution function, enabling the solvation dynamics around the catalytically active iridium sites to be robustly characterized. Our results provide evidence for the coordination of the iridium atoms by the acetonitrile solvent and demonstrate the viability of using diffuse X-ray scattering at free-electron laser sources for studying the dynamics of photocatalysis.

  12. Integrated Methods for Site Characterization and Conceptual Model Development for a Contaminated Fractured-Bedrock Aquifer

    Science.gov (United States)

    Johnson, C. D.; Kastrinos, J. R.; Haeni, F. P.

    2005-12-01

    A multi-disciplined and team-based approach was used to integrate geophysical, hydrologic, and chemical data to characterize lithology, fractures, and hydraulic properties of fractured crystalline bedrock and to determine the nature and extent of ground-water contamination from a landfill and former chemical-waste disposal pits at the University of Connecticut. Detection of volatile organic compounds (VOCs) in domestic bedrock wells in the mid-1980s led to this investigation, in which a team comprised of hydrologists, engineers, geophysicists, geologists, chemists, toxicologists, and community-involvement personnel collected, analyzed, and evaluated data; developed and refined a conceptual model of the ground-water flow and contaminant distribution at the site; and evaluated alternatives and implemented a final remediation plan. The characterization phase began in 1999 and the remediation phase is currently ongoing. An integrated and iterative approach of using multiple methods in phases was important for corroborating the interpretation of individual methods and essential for guiding the design and implementation of additional testing at the site. The use of geophysical data early in the investigation allowed the study team to obtain detailed subsurface information using a minimum of boreholes. Surface geophysical methods were used to target potential discharge of contaminants from the landfill for further investigation. Borehole geophysical methods were used to investigate the anomalies identified by surface geophysical methods, the location and orientation of fractures that intersect and surround each well, the direction and magnitude of ambient flow in the wells, and the transmissive fractures that could provide pathways for contaminant migration. Borehole geophysical and hydraulic data were used to design discrete-zone monitoring systems for the collection of hydraulic head and chemical data and to prevent cross contamination through the boreholes. The results

  13. Walker Branch Throughfall Displacement Experiment Data Report: Site Characterization, System Performance, Weather, Species Composition, and Growth

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, P.J.

    2001-09-04

    This numeric data package provides data sets, and accompanying documentation, on site characterization, system performance, weather, species composition, and growth for the Throughfall Displacement Experiment, which was established in the Walker Branch Watershed of East Tennessee to provide data on the responses of forests to altered precipitation regimes. The specific data sets include soil water content and potential, coarse fraction of the soil profile, litter layer temperature, soil temperature, monthly weather, daily weather, hourly weather, species composition of trees and saplings, mature tree and sapling annual growth, and relative leaf area index. Fortran and SAS{trademark} access codes are provided to read the ASCII data files. The data files and this documentation are available without charge on a variety of media and via the Internet from the Carbon Dioxide Information Analysis Center (CDIAC).

  14. Characterization of ventilation ductwork in Building K-33 at the Oak Ridge K-25 Site

    Energy Technology Data Exchange (ETDEWEB)

    Mrochek, J.E.

    1992-05-01

    An extensive sampling and analysis program was initiated in September 1991 to characterize the ductwork of Building K-33, which is located at the Oak Ridge K-25 Site. This building, 32.4 acres under roof, contains nearly 3 miles of main plenums without considering the side laterals, which are extensive. A large number (i.e., 131) of hexane-moistened wipe samples were taken from within randomly selected locations in the 16 main plenums and the side lateral network. Samples were analyzed for polychlorinated biphenyls (PCBs), uranium, and technetium. These samples were augmented by 5 bulk material and 13 metal coupon samples that were subjected to TCLP (Toxicity Characteristic Leaching Procedure) analyses for arsenic, barium, cadmium, chromium, lead, nickel, selenium, silver, and mercury.

  15. A New Tool for Automated Data Collection and Complete On-site Flux Data Processing for Eddy Covariance Measurements

    Science.gov (United States)

    Begashaw, I. G.; Kathilankal, J. C.; Li, J.; Beaty, K.; Ediger, K.; Forgione, A.; Fratini, G.; Johnson, D.; Velgersdyk, M.; Hupp, J. R.; Xu, L.; Burba, G. G.

    2014-12-01

    The eddy covariance method is widely used for direct measurements of turbulent exchange of gases and energy between the surface and atmosphere. In the past, raw data were collected first in the field and then processed back in the laboratory to achieve fully corrected publication-ready flux results. This post-processing consumed significant amount of time and resources, and precluded researchers from accessing near real-time final flux results. A new automated measurement system with novel hardware and software designs was developed, tested, and deployed starting late 2013. The major advancements with this automated flux system include: 1) Enabling logging high-frequency, three-dimensional wind speeds and multiple gas densities (CO2, H2O and CH4), low-frequency meteorological data, and site metadata simultaneously through a specially designed file format 2) Conducting fully corrected, real-time on-site flux computations using conventional as well as user-specified methods, by implementing EddyPro Software on a small low-power microprocessor 3) Providing precision clock control and coordinate information for data synchronization and inter-site data comparison by incorporating a GPS and Precision Time Protocol. Along with these innovations, a data management server application was also developed to chart fully corrected real-time fluxes to assist remote system monitoring, to send e-mail alerts, and to automate data QA/QC, transfer and archiving at individual stations or on a network level. Combination of all of these functions was designed to help save substantial amount of time and costs associated with managing a research site by eliminating the post-field data processing, reducing user errors and facilitating real-time access to fully corrected flux results. The design, functionality, and test results from this new eddy covariance measurement tool will be presented.

  16. Status of volcanism studies for the Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Crowe, B.; Perry, F.; Murrell, M.; Poths, J.; Valentine, G.A. [Los Alamos National Lab., NM (United States); Wells, S. [Univ. of California, Riverside, CA (United States); Bowker, L.; Finnegan, K. [Univ. of Nevada, Las Vegas, NV (United States); Geissman, J.; McFadden, L.

    1995-02-01

    Chapter 1 introduces the volcanism issue for the Yucca Mountain site and provides the reader with an overview of the organization, content, and significant conclusions of this report. The risk of future basaltic volcanism is the primary topic of concern including both events that intersect a potential repository and events that occur near or within the waste isolation system of a repository. Chapter 2 describes the volcanic history of the Yucca Mountain region (YMR) and emphasizes the Pliocene and Quaternary volcanic record, the interval of primary concern for volcanic risk assessment. The Lathrop Wells volcanic center is described in detail because it is the youngest basalt center in the YMR. Chapter 3 describes the tectonic setting of the YMR and presents and assesses the significance of multiple alternative tectonic models. Geophysical data are described for the YMR and are used as an aid to understand the distribution of basaltic volcanic centers. Chapter 4 discusses the petrologic and geochemical features of basaltic volcanism in the YMR, the southern Great Basin and the Basin and Range province. The long time of activity and characteristic small volume of the Postcaldera basalt of the YMR result in one of the lowest eruptive rates in a volcanic field in the southwest United States. Chapter 5 summarizes current concepts of the segregation, ascent, and eruption of basalt magma. Chapter 6 summarizes the history of volcanism studies (1979 through early 1994), including work for the Yucca Mountain Site Characterization Project and overview studies by the state of Nevada and the Nuclear Regulatory Commission. Chapter 7 summarizes probabilistic volcanic hazard assessment using a three-part conditional probability model. Chapter 8 describes remaining volcanism work judged to be needed to complete characterization studies for the YMR. Chapter 9 summarizes the conclusions of this volcanism status report.

  17. Characterization of the Inner Knot of the Crab: the Site of the Gamma-ray Flares?

    Science.gov (United States)

    Weisskopf, Martin C.

    2015-01-01

    One of the most intriguing recent discoveries has been the detection of powerful gamma-ray flares from the Crab Nebula. Such events, with a recurrence time of about once per year, can be so dramatic to make the system the brightest source in the gamma-ray sky as occurred, e.g. in April 2011. These flares challenge our understanding of how pulsar wind nebulae work and defy current astrophysical models for particle acceleration. We present here our study of the inner knot located within a fraction of an arcsecond from the pulsar with the aim of characterizing the feature and asking if this might be the site of the origin of the gamma-ray flares. We took data using Keck, HST, and Chandra obtained as part of our multi-wavelength campaign to identify the source of the enigmatic flares. We set an upper limit as to the gamma-ray flux from the knot. We also find that the dimensions, surface brightness, flux, etc. of the optical and infrared knot are all correlated with distance from the pulsar. This distance, in turn, varies with time. In addition to this most thorough characterization of the inner knot's properties, we examine the hypothesis that the knot may be the site of the flares by examining the knot separation versus the Fermi/LAT gamma-ray flux. Finally, as part of this research, we make use of a new approach employing singular value decomposition (SVD) for analyzing time series of images and compare the approach to more traditional methods. Our conclusions are only refined but not impacted by using the new approach.

  18. Remote sensing supported surveillance and characterization of tailings behavior at a gold mine site, Finland.

    Science.gov (United States)

    Rauhala, Anssi; Tuomela, Anne; Rossi, Pekka M.; Davids, Corine

    2017-04-01

    The management of vast amounts of tailings produced is one of the key issues in mining operations. The effective and economic disposal of the waste requires knowledge concerning both basic physical properties of the tailings as well as more complex aspects such as consolidation behavior. The behavior of tailings in itself is a very complex issue that can be affected by flocculation, sedimentation, consolidation, segregation, deposition, freeze-thaw, and desiccation phenomena. The utilization of remote sensing in an impoundment-scale monitoring of tailings could benefit the management of tailings, and improve our knowledge on tailings behavior. In order to gain better knowledge of tailings behavior in cold climate, we have utilized both modern remote sensing techniques and more traditional in situ and laboratory measurements in characterizing thickened gold tailings behavior at a Finnish gold mine site, where the production has been halted due to low gold prices. The remote sensing measurements consisted of elevation datasets collected from unmanned aerial vehicles during summers 2015 and 2016, and a further campaign is planned for the summer 2017. The ongoing traditional measurements include for example particle-size distribution, frost heave, frost depth, water retention, temperature profile, and rheological measurements. Initial results from the remote sensing indicated larger than expected settlements on parts of the tailings impoundment, and also highlighted some of the complexities related to data processing. The interpretation of the results and characterization of the behavior is in this case complicated by possible freeze-thaw effects and potential settlement of the impoundment bottom structure consisting of natural peat. Experiments with remote sensing and unmanned aerial vehicles indicate that they could offer potential benefits in frequent mine site monitoring, but there is a need towards more robust and streamlined data acquisition and processing. The

  19. Characterization of the transverse phase space at the photo-injector test facility in DESY, Zeuthen site

    Energy Technology Data Exchange (ETDEWEB)

    Staykov, Lazar

    2012-10-15

    High brightness electron beams with charge of 1 nC and low transverse emittance are necessary for the functioning of advanced light sources such as the Free-electron Laser in Hamburg (FLASH) and the European X-ray FEL (XFEL). The photo-injector test facility at DESY, Zeuthen site (PITZ) is dedicated to the optimization of such electron beams. At PITZ the electrons are produced using an RF gun cavity operated at accelerating gradients of up to 60 MV/m. The gun is equipped with a pair of solenoids for the compensation of the emittance growth due to linear space charge forces. This solenoid compensation scheme is enhanced with a properly matched TESLA type normal conducting booster cavity. The main tool for the characterization of the transverse phase space of the electron beam at PITZ is the emittance measurement system (EMSY). It employs the single slit method for the measurement of the transverse phase space distribution of the electron beam. In this thesis, the performance of the EMSY was optimized for measurement of low emittances in a wide range of photo-injector parameters including such that result in electron beams close to the XFEL specifications. First results on the characterization of the PITZ photo-injector with a gun operated at maximum accelerating gradient of 60 MV/m are presented. This includes scans of the solenoid focusing strength, the initial beam size and the booster gradient. A comparison between results obtained at lower accelerating gradients is made with emphasize on the benefit of higher accelerating gradient.

  20. Seismic Site Characterizations and Earthquake Loss Estimation Analyses for K-12 Schools in Washington State

    Science.gov (United States)

    Cakir, R.; Walsh, T. J.; Hayashi, K.; Norman, D. K.; Lau, T.; Scott, S.

    2016-12-01

    Washington State has the second-highest earthquake risk in the U.S. after only California, and major earthquakes in western Washington in 1946, 1949, 1965, and 2001 killed 15 people and caused billions of dollars' worth of property damage. Washington State has not been exempt from earthquake damage to school buildings. The mission of The Washington Department of Natural Resources-Division of Geology and Earth Resources is to "reduce or eliminate risks to life and property from natural hazards." We conducted active and passive seismic surveys, and estimated shear-wave velocity (Vs) profiles, then determined NEHRP soil classifications using calculated Vs30m values at public schools in Thurston, Grays Harbor, Walla Walla, Chelan and Okanogan counties, Washington. We used active and passive seismic surveys: 1D and 2D MASW and MAM, P- and S-wave refraction, horizontal-to-vertical spectral ratio (H/V), and 2-Station SPAC (2ST-SPAC) surveys to measure Vs and Vp at shallow (0-70m) and Vs at greater (10 to 500 or 10 -3000 meters) depths at the sites, respectively. We then ran Ground Penetrating Radar (GPR) surveys along each seismic line to check possible horizontal subsurface variations between the survey line and the actual location of the school buildings. These survey results were then used for calculations of Vs30m to determine the NEHRP site classifications at school sites. These site classes were also used for determining soil amplification effects on the ground motions affecting structural damage estimations of the school buildings. These seismic site characterization results associated with structural engineering evaluations were then used as inputs in FEMA Hazus-Advanced Engineering Building Module (AEBM) analysis to provide estimated casualties, nonstructural, and structural losses. The final AEBM loss estimation along with the more detailed structural evaluations will help school districts assess the earthquake performance of school buildings in order to

  1. Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site.

    Science.gov (United States)

    Huang, Lin-Ya; Patel, Ami; Ng, Robert; Miller, Edward Blake; Halder, Sujata; McKenna, Robert; Asokan, Aravind; Agbandje-McKenna, Mavis

    2016-06-01

    The adeno-associated viruses (AAVs), which are being developed as gene delivery vectors, display differential cell surface glycan binding and subsequent tissue tropisms. For AAV serotype 1 (AAV1), the first viral vector approved as a gene therapy treatment, and its closely related AAV6, sialic acid (SIA) serves as their primary cellular surface receptor. Toward characterizing the SIA binding site(s), the structure of the AAV1-SIA complex was determined by X-ray crystallography to 3.0 Å. Density consistent with SIA was observed in a pocket located at the base of capsid protrusions surrounding icosahedral 3-fold axes. Site-directed mutagenesis substitution of the amino acids forming this pocket with structurally equivalent residues from AAV2, a heparan sulfate binding serotype, followed by cell binding and transduction assays, further mapped the critical residues conferring SIA binding to AAV1 and AAV6. For both viruses five of the six binding pocket residues mutated (N447S, V473D, N500E, T502S, and W503A) abolished SIA binding, whereas S472R increased binding. All six mutations abolished or decreased transduction by at least 50% in AAV1. Surprisingly, the T502S substitution did not affect transduction efficiency of wild-type AAV6. Furthermore, three of the AAV1 SIA binding site mutants-S472R, V473D, and N500E-escaped recognition by the anti-AAV1 capsid antibody ADK1a. These observations demonstrate that common key capsid surface residues dictate both virus binding and entry processes, as well as antigenic reactivity. This study identifies an important functional capsid surface "hot spot" dictating receptor attachment, transduction efficiency, and antigenicity which could prove useful for vector engineering. The adeno-associated virus (AAV) vector gene delivery system has shown promise in several clinical trials and an AAV1-based vector has been approved as the first gene therapy treatment. However, limitations still exist with respect to transduction efficiency and

  2. Detailed Geophysical Fault Characterization in Yucca Flat, Nevada Test Site, Nevada

    Science.gov (United States)

    Asch, Theodore H.; Sweetkind, Donald S.; Burton, Bethany L.; Wallin, Erin L.

    2009-01-01

    Yucca Flat is a topographic and structural basin in the northeastern part of the Nevada Test Site (NTS) in Nye County, Nevada. Between the years 1951 and 1992, 659 underground nuclear tests took place in Yucca Flat; most were conducted in large, vertical excavations that penetrated alluvium and the underlying Cenozoic volcanic rocks. Radioactive and other potential chemical contaminants at the NTS are the subject of a long-term program of investigation and remediation by the U.S. Department of Energy (DOE), National Nuclear Security Administration, Nevada Site Office, under its Environmental Restoration Program. As part of the program, the DOE seeks to assess the extent of contamination and to evaluate the potential risks to humans and the environment from byproducts of weapons testing. To accomplish this objective, the DOE Environmental Restoration Program is constructing and calibrating a ground-water flow model to predict hydrologic flow in Yucca Flat as part of an effort to quantify the subsurface hydrology of the Nevada Test Site. A necessary part of calibrating and evaluating a model of the flow system is an understanding of the location and characteristics of faults that may influence ground-water flow. In addition, knowledge of fault-zone architecture and physical properties is a fundamental component of the containment of the contamination from underground nuclear tests, should such testing ever resume at the Nevada Test Site. The goal of the present investigation is to develop a detailed understanding of the geometry and physical properties of fault zones in Yucca Flat. This study was designed to investigate faults in greater detail and to characterize fault geometry, the presence of fault splays, and the fault-zone width. Integrated geological and geophysical studies have been designed and implemented to work toward this goal. This report describes the geophysical surveys conducted near two drill holes in Yucca Flat, the data analyses performed, and the

  3. Statistical analysis of hydrologic data for Yucca Mountain; Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Rutherford, B.M.; Hall, I.J.; Peters, R.R.; Easterling, R.G.; Klavetter, E.A.

    1992-02-01

    The geologic formations in the unsaturated zone at Yucca Mountain are currently being studied as the host rock for a potential radioactive waste repository. Data from several drill holes have been collected to provide the preliminary information needed for planning site characterization for the Yucca Mountain Project. Hydrologic properties have been measured on the core samples and the variables analyzed here are thought to be important in the determination of groundwater travel times. This report presents a statistical analysis of four hydrologic variables: saturated-matrix hydraulic conductivity, maximum moisture content, suction head, and calculated groundwater travel time. It is important to modelers to have as much information about the distribution of values of these variables as can be obtained from the data. The approach taken in this investigation is to (1) identify regions at the Yucca Mountain site that, according to the data, are distinctly different; (2) estimate the means and variances within these regions; (3) examine the relationships among the variables; and (4) investigate alternative statistical methods that might be applicable when more data become available. The five different functional stratigraphic units at three different locations are compared and grouped into relatively homogeneous regions. Within these regions, the expected values and variances associated with core samples of different sizes are estimated. The results provide a rough estimate of the distribution of hydrologic variables for small core sections within each region.

  4. Microdiffraction imaging—a suitable tool to characterize organic electronic devices

    Directory of Open Access Journals (Sweden)

    Clemens Liewald

    2015-10-01

    Full Text Available Tailoring device architecture and active film morphology is crucial for improving organic electronic devices. Therefore, knowledge about the local degree of crystallinity is indispensable to gain full control over device behavior and performance. In this article, we report on microdiffraction imaging as a new tool to characterize organic thin films on the sub-micron length scale. With this technique, which was developed at the ID01 beamline at the ESRF in Grenoble, a focused X-ray beam (300 nm diameter, 12.5 keV energy is scanned over a sample. The beam size guarantees high resolution, while material and structure specificity is gained by the choice of Bragg condition.Here, we explore the possibilities of microdiffraction imaging on two different types of samples. First, we measure the crystallinity of a pentacene thin film, which is partially buried beneath thermally deposited gold electrodes and a second organic film of fullerene C60. The data shows that the pentacene film structure is not impaired by the subsequent deposition and illustrates the potential of the technique to characterize artificial structures within fully functional electronic devices. Second, we investigate the local distribution of intrinsic polymorphism of pentacene thin films, which is very likely to have a substantial influence on electronic properties of organic electronic devices. An area of 40 μm by 40 μm is scanned under the Bragg conditions of the thin-film phase and the bulk phase of pentacene, respectively. To find a good compromise between beam footprint and signal intensity, third order Bragg condition is chosen. The scans show complementary signal distribution and hence demonstrate details of the crystalline structure with a lateral resolution defined by the beam footprint (300 nm by 3 μm.The findings highlight the range of applications of microdiffraction imaging in organic electronics, especially for organic field effect transistors and for organic solar

  5. Characterization of DNA binding sites of the ComE response regulator from Streptococcus mutans.

    Science.gov (United States)

    Hung, David C I; Downey, Jennifer S; Ayala, Eduardo A; Kreth, Jens; Mair, Richard; Senadheera, Dilani B; Qi, Fengxia; Cvitkovitch, Dennis G; Shi, Wenyuan; Goodman, Steven D

    2011-07-01

    In Streptococcus mutans, both competence and bacteriocin production are controlled by ComC and the ComED two-component signal transduction system. Recent studies of S. mutans suggested that purified ComE binds to two 11-bp direct repeats in the nlmC-comC promoter region, where ComE activates nlmC and represses comC. In this work, quantitative binding studies and DNase I footprinting analysis were performed to calculate the equilibrium dissociation constant and further characterize the binding site of ComE. We found that ComE protects sequences inclusive of both direct repeats, has an equilibrium dissociation constant in the nanomolar range, and binds to these two direct repeats cooperatively. Furthermore, similar direct repeats were found upstream of cslAB, comED, comX, ftf, vicRKX, gtfD, gtfB, gtfC, and gbpB. Quantitative binding studies were performed on each of these sequences and showed that only cslAB has a similar specificity and high affinity for ComE as that seen with the upstream region of comC. A mutational analysis of the binding sequences showed that ComE does not require both repeats to bind DNA with high affinity, suggesting that single site sequences in the genome may be targets for ComE-mediated regulation. Based on the mutational analysis and DNase I footprinting analysis, we propose a consensus ComE binding site, TCBTAAAYSGT.

  6. Strategic Petroleum Reserve (SPR) additional geologic site characterization studies, Bayou Choctaw salt dome, Louisiana

    Energy Technology Data Exchange (ETDEWEB)

    Neal, J.T. [Sandia National Labs., Albuquerque, NM (United States); Magorian, T.R. [Magorian (Thomas R.), Amherst, NY (United States); Byrne, K.O.; Denzler, S. [Acres International Corp., Amherst, NY (United States)

    1993-09-01

    This report revises and updates the geologic site characterization report that was published in 1980. Revised structure maps and sections show interpretative differences in the dome shape and caprock structural contours, especially a major east-west trending shear zone, not mapped in the 1980 report. Excessive gas influx in Caverns 18 and 20 may be associated with this shear zone. Subsidence values at Bayou Choctaw are among the lowest in the SPR system, averaging only about 10 mm/yr but measurement and interpretation issues persist, as observed values often approximate measurement accuracy. Periodic, temporary flooding is a continuing concern because of the low site elevation (less than 10 ft), and this may intensify as future subsidence lowers the surface even further. Cavern 4 was re-sonared in 1992 and the profiles suggest that significant change has not occurred since 1980, thereby reducing the uncertainty of possible overburden collapse -- as occurred at Cavern 7 in 1954. Other potential integrity issues persist, such as the proximity of Cavern 20 to the dome edge, and the narrow web separating Caverns 15 and 17. Injection wells have been used for the disposal of brine but have been only marginally effective thus far; recompletions into more permeable lower Pleistocene gravels may be a practical way of increasing injection capacity and brinefield efficiency. Cavern storage space is limited on this already crowded dome, but 15 MMBBL could be gained by enlarging Cavern 19 and by constructing a new cavern beneath and slightly north of abandoned Cavern 13. Environmental issues center on the low site elevation: the backswamp environment combined with the potential for periodic flooding create conditions that will require continuing surveillance.

  7. Subsurface soil characterization using geoelectrical and geotechnical investigations at a bridge site in Uttarakhand Himalayan region

    Science.gov (United States)

    Devi, Anita; Israil, M.; Anbalagan, R.; Gupta, Pravin K.

    2017-09-01

    Geoelectrical characterization of subsurface soil has been done at a bridge foundation site on the banks of Bhagirathi River at Tehri reservoir site, Uttarakhand, India. For this purpose, the Electrical Resistivity Tomography (ERT) and the Standard Penetration Test (SPT) data, recorded at both banks of Bhagirathi River are analyzed. A total of six ERT profiles, recorded on both the West and East banks, were interpreted to determine an electrical resistivity image showing the resistivity variations with depth. The borehole data and geological inputs were used for lithological correlation and calibration of the resistivity values to the subsurface formation. Subsequently the electrical parameter (resistivity) for different subsurface lithological units has been inferred. Further, at selected points, the electrical resistivity sounding data, derived from the ERT, have been correlated with the Standard Penetration Test (SPT) data. This correlation results from the fact that in the subsurface soil both the electrical resistivity variations and the soil strength measured by SPT are controlled by the soil properties: grain size distribution, compactness, porosity and water saturation. It has been observed that the N-values smaller than 16 are unreliable and inconsistent. In the River Borne Material (RBM) on the West Bank it is due to the presence of coarse gravels while on the East Bank it is due to the boulders. The N-values greater than 16 mainly correspond to the weathered rock formation. For these values, there exists a linear relationship between N-values and resistivity with a correlation coefficient greater than 0.80. The coefficients of linear relationship at the two banks vary due to varying amount of clay content. Such a relationship is important for any site in tough Himalayan terrain because it can be used as an alternative to the SPT for determining soil strength parameters from ERT.

  8. Dynamic characterization of fractured carbonates at the Hontomín CO2 storage site

    Science.gov (United States)

    Le Gallo, yann; de Dios, José Carlos; Salvador, Ignacio; Acosta Carballo, Taimara

    2017-04-01

    The geological storage of CO2 is investigated at the Technology Development Plant (TDP) at Hontomín (Burgos, Spain) into a deep saline aquifer, formed by fractured carbonates with poor matrix porosity. During the hydraulic characterization tests, 2,300 tons of liquid CO2 and 14,000 m3 synthetic brine were co-injected on site in various sequences to determine the pressure and temperature responses of the facture network. The results of the pressure tests were analyzed using an analytical approach to determine the overall petrophysical characteristics of the storage formation. Later on, these characteristics were implemented in a 3-D numerical model. The model is a compositional dual medium (fracture + matrix) which accounts for temperature effects, as CO2 is liquid at the well bottom-hole, and multiphase flow hysteresis as alternating water and CO2 injection tests were performed. The pressure and temperature responses of the storage formation were history-matched mainly through the petrophysical and geometrical characteristics of the facture network. This dynamic characterization of the fracture network controls the CO2 migration while the matrix does not appear to significantly contribute to the storage capacity. Consequently, the hydrodynamic behavior of the aquifer is one of the main challenge of the modeling workflow.

  9. Near-surface test facility. Phase I. Geologic site characterization report

    Energy Technology Data Exchange (ETDEWEB)

    Moak, D.J.; Wintczak, T.M.

    1980-08-01

    The report is a description of the geology and characterization of the rock mass of the area in which the Phase I qualification tests at the Near-Surface Test Facility (NSTF) are being performed. The NSTF is located on Gable Mountain within the Hanford Site near Richland, Washington. It is located in the entablature of the Pomona Member, an upper flow in the Columbia River Basalt Group, and is approximately 150 feet (47.5 meters) below the surface. Core logging from the instrument boreholes coupled with joint mapping, statistics, and other test data provided the basis for a detailed characterization of the 16-foot x 20-foot x 28-foot (5-meter x 6-meter x 9-meter) rock masses surrounding Full-Scale Heater Tests No. 1 and No. 2. The Pomona entablature contains three joint sets delineated by their degree of dip, each with apertures averaging 0.25 millimeter and having no preferred strike orientation. Although joint frequencies in the study area exceed 4 joints per foot (13 per meter), the rock-mass classification rating is good.

  10. Radioecological characterization of a uranium mining site located in a semi-arid region in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Horst M. [Instituto de Radioprotecao e Dosimetria, Environmental Impact Assessment, Av. Salvador Allende s/n - Recreio, 22780-160, Rio de Janeiro (Brazil) and University of Central Florida (United States)]. E-mail: monkenhorst@yahoo.com.br; Lamego Simoes Filho, F. Fernando [Instituto de Radioprotecao e Dosimetria, Environmental Impact Assessment, Av. Salvador Allende s/n - Recreio, 22780-160, Rio de Janeiro (Brazil); Perez, Valeska [Instituto de Engenharia Nuclear (Brazil); Franklin, Mariza Ramalho [Instituto de Radioprotecao e Dosimetria, Environmental Impact Assessment, Av. Salvador Allende s/n - Recreio, 22780-160, Rio de Janeiro (Brazil); Gomiero, Luiz Alberto [Industrias Nucleares do Brasil (Brazil)

    2006-07-01

    The work presents the radioecological characterization of the new Brazilian uranium mining and milling site located in a semi-arid region of the country. The process characterization demonstrated that in heap leach plants most of the {sup 226}Ra remains in the leached ore. Despite the potential higher availability of radium isotopes in the soils of the studied region the lack of precipitation in that area reduces the leaching/mobilization of the radionuclides. High {sup 226}Ra and {sup 228}Ra concentrations were found in manioc while {sup 21}Pb was significant in pasture. It was suggested that a range from 10{sup -3} to 10{sup -1} may conveniently encompass most of the transfer factors (TF) values for soil/plant systems (i.e. involving different cultures, different soils and natural radionuclides). Impacts due to aerial transportation of aerosols and radon generated in the mining were proved to be minimal and restricted to an area not greater than 15 km{sup 2}. Finally, uranium complexation by carbonates was shown to be the main mechanism responding for the elevated radionuclide concentration in groundwater.

  11. Characterization of change in the Harike wetland, a Ramsar site in India, using landsat satellite data.

    Science.gov (United States)

    Mabwoga, Samson Okongo; Thukral, Ashwani Kumar

    2014-01-01

    The increasing population in the developing countries has rendered wetlands vulnerable to land use changes. Remote sensing offers a rapid and efficient means of data acquisition of ecosystems in time and space. The present study was undertaken to identify changes in the Harike wetland, a Ramsar site in the state of Punjab, India; and identify causal factors, as well as vulnerable areas threatened from the land cover changes. Unsupervised classification and post-classification change detection techniques were applied to Landsat Thematic Mapper (TM) and Enhanced Thematic Mapper Plus (ETM+) data of 16-10-1989, 22-10-2000 and 26-10-2010. Images were classified into five land cover classes (1) Waterbody, (2) Wetland I, (3) Wetland II, (4) Barren land and (5) Agricultural land. Land cover change is characterized mainly by a decrease in the wetland area, as indicated by decrease in wetland vegetation and an increase in non-wetland areas, characterized by increasing agricultural and barren land areas. Overall, the wetland shrunk by 13% from 1989 to 2010, with the north-eastern side experiencing maximum shrinkage. The wetland needs immediate reclamation to check it from further shrinkage so as to save its biodiversity.

  12. Characterizing the Catalytic Potential of Deinococcus, Arthrobacter and other Robust Bacteria in Contaminated Subsurface Environments of the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Daly, Michael J.

    2005-06-01

    Natural selection in highly radioactive waste sites may yield bacteria with favorable bioremediating characteristics. However, until recently the microbial ecology of such environments has remained unexplored because of the high costs and technical complexities associated with extracting and characterizing samples from such sites. We have examined the bacterial ecology within radioactive sediments from a high-level nuclear waste plume in the vadose zone on the DOE?s Hanford Site in south-central Washington state (Fredrickson et al, 2004). Manganese-dependent, radiation resistant bacteria have been isolated from this contaminated site including the highly Mn-dependent Deinococcus and Arthrobacter spp.

  13. Geoelectrical characterization of a site with hydrocarbon contamination caused by pipeline leakage

    Energy Technology Data Exchange (ETDEWEB)

    Delgado-Rodriguez, Omar; Shevnin, Vladimir; Ochoa-Valdes, Jesus [Instituto Mexicano del Petroleo, Mexico, D.F. (Mexico); Ryjov, Albert [Moscow State Geological Prospecting Academy, Moscow (Russian Federation)

    2006-01-15

    Vertical Electrical Sounding (VES) method is used extensively in environmental impact studies including hydrocarbon contamination. In this work, the results of the geoelectrical characterization of a contaminated site caused by pipeline leakage are presented. Geoelectrical study was performed with multi-electrode technology and 2D profile data interpretation. VES results from six parallel profiles were presented in resistivity sections and maps. Layered model of the site was found including aquifer and aquitard layers. Although the contamination grade of the site is low, we found two contaminated zones into sandy aquifer. Aquifer and aquitard were characterized by its resistivity, clay content, porosity and cation exchange capacity values. Recalculation of resistivity data into petrophysical sections and maps was performed by an inversion algorithm taking into account pore water salinity. Petrophysical parameters for uncontaminated areas estimated from resistivity are close to real values; meanwhile, in contaminated zones petrophysical parameters have anomalous values. Similar effects of contamination influence on petrophysical parameters were found in laboratory by resistivity measurements made at clean and contaminated sand samplers. [Spanish] El metodo Sondeo Electrico Vertical (SEV) es ampliamente utilizado en estudios de impacto ambiental incluyendo el caso de contaminacion por hidrocarburos. En este trabajo se presentan los resultados de la caracterizacion geoelectrica de un sitio contaminado por hidrocarburos relacionado con una fuga en linea de ducto. El estudio geoelectrico fue realizado utilizando el metodo SEV en la variante de tomografia, realizandose una interpretacion 2D de los datos observados. Seis perfiles paralelos de SEV fueron medidos y presentados sus resultados en secciones y mapas. Se determino un modelo estratificado que incluye acuitardo y acuifero. Aunque el grado de contaminacion en este sitio es bajo fue posible localizar dos zonas

  14. LEAF WASHING AS AN ASSESSMENT TOOL TO CHARACTERIZE DRY ATMOSPHERIC DEPOSITION

    Directory of Open Access Journals (Sweden)

    Livia Vittori Antisari

    2012-12-01

    Full Text Available The aim of this work was to characterize dry atmospheric deposition after the washing of broad leaves and conifer foliage. To assess this method different sites chosen on the basis of different exposure to both point (e.g. waste incinerator plant (WIP, local crafts and widespread (e.g. roads, agricultural practices sources of anthropogenic pollution.The principal components analysis (PCA, performed on the major and trace elements identified after leaf washing, extracted four factors. F2 was lithogenic while the other three were anthropogenic. The enrichment factor (EF highlights that Cd, Cu and Zn had a purely anthropogenic origin. The sites were grouped according to the predominant source of exposure and the synthetic index of enrichment (SIE showed a decrease as follows: downwind from WIP > max exposure to WIP > min exposure to WIP > road > craft > rural zone.The leaf area allows to calculate the annual flow of elements and the deposition flux in the study area varied for Cd from 0.07 to 0.55 mg m-2, for Co from 0.1 to 0.48 mg m-2, for Cr from 0.63 to 3.7 mg m-2, for Cu from 14.5 to 32.27 mg m-2. The Cd flux in the Bologna area was lower than in some industrial zones of the World and the lowest values were found in the rural zones and under a minimum exposure to the incinerator plant, while the highest values were near the roads and under maximum exposure to the incinerator. The direct analysis of the leaf-washing water allows to discriminate the anthropogenic or geogenic metals deposited on the leaves using multivariate statistical analysis. It is also possible to predict the flow of metals in different areas of investigation.

  15. A first principles atmospheric propagation & characterization tool: the laser environmental effects definition and reference (LEEDR)

    Science.gov (United States)

    Fiorino, Steven T.; Bartell, Richard J.; Krizo, Matthew J.; Caylor, Gregory L.; Moore, Kenneth P.; Harris, Thomas R.; Cusumano, Salvatore J.

    2008-02-01

    The Air Force Institute of Technology Center for Directed Energy (AFIT/CDE) has developed a first principles atmospheric propagation and characterization model called the Laser Environmental Effects Definition and Reference or LEEDR. This package enables the creation of profiles of temperature, pressure, water vapor content, optical turbulence, and atmospheric particulates and hydrometeors as they relate to line-by-line layer extinction coefficient magnitude at wavelengths from the UV to the RF. Worldwide seasonal, diurnal, and geographical variability in these parameters is accessed from probability density function (PDF) databases using a variety of recently available resources to include the Extreme and Percentile Environmental Reference Tables (ExPERT), the Master Database for Optical Turbulence Research in Support of the Airborne Laser, and the Global Aerosol Data Set (GADS). GADS provides aerosol constituent number densities on a 5° x 5° grid worldwide. ExPERT mapping software allows the LEEDR operator to choose from specific site or regional upper air data to characterize correlated molecular absorption, aerosol absorption and scattering by percentile. The integration of the Surface Marine Gridded Climatology database, the Advanced Navy Aerosol Model (ANAM), and the Navy Surface Layer Optical Turbulence (NSLOT) model provides worldwide coverage over all ocean regions on a 1° x 1° grid. Molecular scattering is computed based on Rayleigh theory. Molecular absorption effects are computed for the top 13 absorbing species using line strength information from the HITRAN 2004 database in conjunction with a community standard molecular absorption continuum code. Aerosol scattering and absorption are computed with the Wiscombe Mie model. Each atmospheric particulate/hydrometeor is evaluated based on its wavelength-dependent forward and off-axis scattering characteristics and absorption effects on laser energy delivered at any wavelength from 0.355 μm to 8.6 m

  16. Seismic site-response characterization of high-velocity sites using advanced geophysical techniques: application to the NAGRA-Net

    Czech Academy of Sciences Publication Activity Database

    Poggi, V.; Burjánek, Jan; Michel, C.; Fäh, D.

    2017-01-01

    Roč. 210, č. 2 (2017), s. 645-659 ISSN 0956-540X Institutional support: RVO:67985530 Keywords : joint inversion * earthquake ground motions * seismic noise * site effects Subject RIV: DC - Siesmology, Volcanology, Earth Structure Impact factor: 2.414, year: 2016

  17. SITE CHARACTERIZATION AND MONITORING DATA FROM THE AREA 5 PILOT WELLS

    Energy Technology Data Exchange (ETDEWEB)

    BECHTEL NEVADA; U.S. DEPARTMENT OF ENERGY, NATIONAL NUCLEAR SECURITY ADMINISTRATION NEVADA SITE OFFICE

    2005-09-01

    Three exploratory boreholes were drilled and completed to the uppermost alluvial aquifer in Area 5 of the Nevada Test Site, Nye County, Nevada, in 1992. The boreholes and associated investigations were part of the Area 5 Site Characterization Program developed to meet data needs associated with regulatory requirements applicable to the disposal of low-level, mixed, and high-specific-activity waste at this site. This series of boreholes was specifically designed to characterize the hydrogeology of the thick vadose zone and to help define the water quality and hydraulic properties of the uppermost aquifer. Wells UE5PW-1, UE5PW-2, and UE5PW-3 are located in a triangular array near the southeast, northeast, and northwest corners, respectively, of the approximately 2.6-square-kilometer Area 5 Radioactive Waste Management Site to give reasonable spatial coverage for sampling and characterization, and to help define the nearly horizontal water table. Two of the wells, UE5PW-1 and UE5PW-2, penetrated only unconsolidated alluvial materials. The third well, located closer to the margin of the basin, penetrated both alluvium and underlying ash-flow and bedded tuff units. The watertable was encountered at the elevation of approximately 734 meters. The results of laboratory testing of core and drill cuttings samples indicate that the mineralogical, material, and hydrologic properties of the alluvium are very similar within and between boreholes. Additional tests on the same core and drill cuttings samples indicate that hydrologic conditions within the alluvium are also similar between pilot wells. Both core and drill cuttings samples are dry (less than 10 percent water content by weight) throughout the entire unsaturated section of alluvium, and water content increases slightly with depth in each borehole. Water potential measurements on core samples show a large positive potential gradient (water tends to move upward, rather than downward) to a depth of approximately 30

  18. Reflectance anisotropy spectroscopy as a tool for mechanical characterization of metallic thin films

    Science.gov (United States)

    Wyss, A.; Schamel, M.; Sologubenko, A. S.; Denk, R.; Hohage, M.; Zeppenfeld, P.; Spolenak, R.

    2015-10-01

    In the present work reflectance anisotropy spectroscopy (RAS) is evaluated as a new tool for the mechanical characterization of metallic thin films on viscoelastic substrates. Cu and Cu-Zn thin films of thicknesses in the range from 50 to 1000 nm were sputter-deposited onto a viscoelastic polyimide substrate and subjected to uniaxial tensile loading. The changes in the mechanical, electrical and optical response of the films upon loading were monitored by simultaneous acquisition of total strain, electrical resistance and the RA-signal. The RA-spectrum of pure copper reveals a feature at a photon energy of ~4.0 eV that linearly increases with strain at the beginning of loading (elastic regime) and saturates at later stages (plastic regime). Post-mortem SEM studies of samples loaded to different strain values confirmed that this saturation corresponds to the onset of plastic deformation, defined by the appearance of slip lines. Concurrent measurements of the electrical resistance confirmed the absence of cracking at the onset of the 4.0 eV RA-signal saturation. Therefore we claim that the RAS technique can be employed for yield point determination. Besides the applicability of the RAS technique for pure metals, chemical sensitivity of RAS in terms of peak position was observed in the case of Cu-Zn thin films.

  19. Acoustic holography as a metrological tool for characterizing medical ultrasound sources and fields

    Science.gov (United States)

    Sapozhnikov, Oleg A.; Tsysar, Sergey A.; Khokhlova, Vera A.; Kreider, Wayne

    2015-01-01

    Acoustic holography is a powerful technique for characterizing ultrasound sources and the fields they radiate, with the ability to quantify source vibrations and reduce the number of required measurements. These capabilities are increasingly appealing for meeting measurement standards in medical ultrasound; however, associated uncertainties have not been investigated systematically. Here errors associated with holographic representations of a linear, continuous-wave ultrasound field are studied. To facilitate the analysis, error metrics are defined explicitly, and a detailed description of a holography formulation based on the Rayleigh integral is provided. Errors are evaluated both for simulations of a typical therapeutic ultrasound source and for physical experiments with three different ultrasound sources. Simulated experiments explore sampling errors introduced by the use of a finite number of measurements, geometric uncertainties in the actual positions of acquired measurements, and uncertainties in the properties of the propagation medium. Results demonstrate the theoretical feasibility of keeping errors less than about 1%. Typical errors in physical experiments were somewhat larger, on the order of a few percent; comparison with simulations provides specific guidelines for improving the experimental implementation to reduce these errors. Overall, results suggest that holography can be implemented successfully as a metrological tool with small, quantifiable errors. PMID:26428789

  20. New tools for characterizing swarming systems: A comparison of minimal models

    Science.gov (United States)

    Huepe, Cristián; Aldana, Maximino

    2008-05-01

    We compare three simple models that reproduce qualitatively the emergent swarming behavior of bird flocks, fish schools, and other groups of self-propelled agents by using a new set of diagnosis tools related to the agents’ spatial distribution. Two of these correspond in fact to different implementations of the same model, which had been previously confused in the literature. All models appear to undergo a very similar order-to-disorder phase transition as the noise level is increased if we only compare the standard order parameter, which measures the degree of agent alignment. When considering our novel quantities, however, their properties are clearly distinguished, unveiling previously unreported qualitative characteristics that help determine which model best captures the main features of realistic swarms. Additionally, we analyze the agent clustering in space, finding that the distribution of cluster sizes is typically exponential at high noise, and approaches a power-law as the noise level is reduced. This trend is sometimes reversed at noise levels close to the phase transition, suggesting a non-trivial critical behavior that could be verified experimentally. Finally, we study a bi-stable regime that develops under certain conditions in large systems. By computing the probability distributions of our new quantities, we distinguish the properties of each of the coexisting metastable states. Our study suggests new experimental analyses that could be carried out to characterize real biological swarms.

  1. Emerging microfluidic tools for functional cellular immunophenotyping: a new potential paradigm for immune status characterization.

    Science.gov (United States)

    Chen, Weiqiang; Huang, Nien-Tsu; Li, Xiang; Yu, Zeta Tak For; Kurabayashi, Katsuo; Fu, Jianping

    2013-01-01

    Rapid, accurate, and quantitative characterization of immune status of patients is of utmost importance for disease diagnosis and prognosis, evaluating efficacy of immunotherapeutics and tailoring drug treatments. Immune status of patients is often dynamic and patient-specific, and such complex heterogeneity has made accurate, real-time measurements of patient immune status challenging in the clinical setting. Recent advances in microfluidics have demonstrated promising applications of the technology for immune monitoring with minimum sample requirements and rapid functional immunophenotyping capability. This review will highlight recent developments of microfluidic platforms that can perform rapid and accurate cellular functional assays on patient immune cells. We will also discuss the future potential of integrated microfluidics to perform rapid, accurate, and sensitive cellular functional assays at a single-cell resolution on different types or subpopulations of immune cells, to provide an unprecedented level of information depth on the distribution of immune cell functionalities. We envision that such microfluidic immunophenotyping tools will allow for comprehensive and systems-level immunomonitoring, unlocking the potential to transform experimental clinical immunology into an information-rich science.

  2. Characterization of materials for a reactive transport model validation experiment: Interim report on the caisson experiment. Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Siegel, M.D.; Cheng, W.C. [Sandia National Labs., Albuquerque, NM (United States); Ward, D.B.; Bryan, C.R. [Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Earth and Planetary Sciences

    1995-08-01

    Models used in performance assessment and site characterization activities related to nuclear waste disposal rely on simplified representations of solute/rock interactions, hydrologic flow field and the material properties of the rock layers surrounding the repository. A crucial element in the design of these models is the validity of these simplifying assumptions. An intermediate-scale experiment is being carried out at the Experimental Engineered Test Facility at Los Alamos Laboratory by the Los Alamos and Sandia National Laboratories to develop a strategy to validate key geochemical and hydrological assumptions in performance assessment models used by the Yucca Mountain Site Characterization Project.

  3. Digital recovery management: Characterizing recovery-specific social network site participation and perceived benefit.

    Science.gov (United States)

    Bergman, Brandon G; Kelly, Nathaniel W; Hoeppner, Bettina B; Vilsaint, Corrie L; Kelly, John F

    2017-06-01

    Research shows that digital social network sites (SNSs) may be valuable platforms to effect health behavior change. Little is known specifically about their ability to help address alcohol and other drug problems. This gap is noteworthy, given that individuals are already participating in existing, recovery-specific SNSs (hereafter referred to as recovery SNSs): online communities with the functionality of conventional SNSs (e.g., Facebook) that focus on substance use disorder (SUD) recovery. For example, InTheRooms.com (ITR) is a large, well-known recovery SNS that is available for free 24 hr/day via website and mobile smartphone applications. It offers recovery tools within a digital social milieu for over 430,000 registered users. To augment the knowledge base on recovery SNS platforms, we conducted an online survey of 123 ITR participants (M = 50.8 years old; 56.9% female; 93.5% White; M = 7.3 years of abstinence, range of 0-30 years; 65% cited alcohol as their primary substance). Respondents engaged with ITR, on average, for about 30 min/day several times each week. Daily meditation prompts and live online video meetings were the most commonly utilized resources. Participants generally endorsed ITR as a helpful platform, particularly with respect to increased abstinence/recovery motivation and self-efficacy. Compared to individuals abstinent for 1 or more years, those abstinent less than 1 year (including nonabstinent individuals) showed similar rates of engagement with ITR activities and similar levels of perceived benefit. Our findings suggest that longitudinal studies are warranted to examine the clinical utility of ITR and other recovery SNSs as SUD treatment adjuncts and/or recovery self-management tools. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  4. Characterization of lithium coordination sites with magic-angle spinning NMR

    Science.gov (United States)

    Haimovich, A.; Goldbourt, A.

    2015-05-01

    Lithium, in the form of lithium carbonate, is one of the most common drugs for bipolar disorder. Lithium is also considered to have an effect on many other cellular processes hence it possesses additional therapeutic as well as side effects. In order to quantitatively characterize the binding mode of lithium, it is required to identify the interacting species and measure their distances from the metal center. Here we use magic-angle spinning (MAS) solid-state NMR to study the binding site of lithium in complex with glycine and water (LiGlyW). Such a compound is a good enzyme mimetic since lithium is four-coordinated to one water molecule and three carboxylic groups. Distance measurements to carbons are performed using a 2D transferred echo double resonance (TEDOR) MAS solid-state NMR experiment, and water binding is probed by heteronuclear high-resolution proton-lithium and proton-carbon correlation (wPMLG-HETCOR) experiments. Both HETCOR experiments separate the main complex from impurities and non-specifically bound lithium species, demonstrating the sensitivity of the method to probe the species in the binding site. Optimizations of the TEDOR pulse scheme in the case of a quadrupolar nucleus with a small quadrupole coupling constant show that it is most efficient when pulses are positioned on the spin-1/2 (carbon-13) nucleus. Since the intensity of the TEDOR signal is not normalized, careful data analysis that considers both intensity and dipolar oscillations has to be performed. Nevertheless we show that accurate distances can be extracted for both carbons of the bound glycine and that these distances are consistent with the X-ray data and with lithium in a tetrahedral environment. The lithium environment in the complex is very similar to the binding site in inositol monophosphatase, an enzyme associated with bipolar disorder and the putative target for lithium therapy. A 2D TEDOR experiment applied to the bacterial SuhB gene product of this enzyme was designed

  5. The Effect of Drag and Attachment Site of External Tags on Swimming Eels: Experimental Quantification and Evaluation Tool

    Science.gov (United States)

    Tudorache, Christian; Burgerhout, Erik; Brittijn, Sebastiaan; van den Thillart, Guido

    2014-01-01

    Telemetry studies on aquatic animals often use external tags to monitor migration patterns and help to inform conservation effort. However, external tags are known to impair swimming energetics dramatically in a variety of species, including the endangered European eel. Due to their high swimming efficiency, anguilliform swimmers are very susceptibility for added drag. Using an integration of swimming physiology, behaviour and kinematics, we investigated the effect of additional drag and site of externally attached tags on swimming mode and costs. The results show a significant effect of a) attachment site and b) drag on multiple energetic parameters, such as Cost Of Transport (COT), critical swimming speed (Ucrit) and optimal swimming speed (Uopt), possibly due to changes in swimming kinematics. Attachment at 0.125 bl from the tip of the snout is a better choice than at the Centre Of Mass (0.35 bl), as it is the case in current telemetry studies. Quantification of added drag effect on COT and Ucrit show a (limited) correlation, suggesting that the Ucrit test can be used for evaluating external tags for telemetry studies until a certain threshold value. Uopt is not affected by added drag, validating previous findings of telemetry studies. The integrative methodology and the evaluation tool presented here can be used for the design of new studies using external telemetry tags, and the (re-) evaluation of relevant studies on anguilliform swimmers. PMID:25409179

  6. The effect of drag and attachment site of external tags on swimming eels: experimental quantification and evaluation tool.

    Science.gov (United States)

    Tudorache, Christian; Burgerhout, Erik; Brittijn, Sebastiaan; van den Thillart, Guido

    2014-01-01

    Telemetry studies on aquatic animals often use external tags to monitor migration patterns and help to inform conservation effort. However, external tags are known to impair swimming energetics dramatically in a variety of species, including the endangered European eel. Due to their high swimming efficiency, anguilliform swimmers are very susceptibility for added drag. Using an integration of swimming physiology, behaviour and kinematics, we investigated the effect of additional drag and site of externally attached tags on swimming mode and costs. The results show a significant effect of a) attachment site and b) drag on multiple energetic parameters, such as Cost Of Transport (COT), critical swimming speed (Ucrit) and optimal swimming speed (Uopt), possibly due to changes in swimming kinematics. Attachment at 0.125 bl from the tip of the snout is a better choice than at the Centre Of Mass (0.35 bl), as it is the case in current telemetry studies. Quantification of added drag effect on COT and Ucrit show a (limited) correlation, suggesting that the Ucrit test can be used for evaluating external tags for telemetry studies until a certain threshold value. Uopt is not affected by added drag, validating previous findings of telemetry studies. The integrative methodology and the evaluation tool presented here can be used for the design of new studies using external telemetry tags, and the (re-) evaluation of relevant studies on anguilliform swimmers.

  7. The effect of drag and attachment site of external tags on swimming eels: experimental quantification and evaluation tool.

    Directory of Open Access Journals (Sweden)

    Christian Tudorache

    Full Text Available Telemetry studies on aquatic animals often use external tags to monitor migration patterns and help to inform conservation effort. However, external tags are known to impair swimming energetics dramatically in a variety of species, including the endangered European eel. Due to their high swimming efficiency, anguilliform swimmers are very susceptibility for added drag. Using an integration of swimming physiology, behaviour and kinematics, we investigated the effect of additional drag and site of externally attached tags on swimming mode and costs. The results show a significant effect of a attachment site and b drag on multiple energetic parameters, such as Cost Of Transport (COT, critical swimming speed (Ucrit and optimal swimming speed (Uopt, possibly due to changes in swimming kinematics. Attachment at 0.125 bl from the tip of the snout is a better choice than at the Centre Of Mass (0.35 bl, as it is the case in current telemetry studies. Quantification of added drag effect on COT and Ucrit show a (limited correlation, suggesting that the Ucrit test can be used for evaluating external tags for telemetry studies until a certain threshold value. Uopt is not affected by added drag, validating previous findings of telemetry studies. The integrative methodology and the evaluation tool presented here can be used for the design of new studies using external telemetry tags, and the (re- evaluation of relevant studies on anguilliform swimmers.

  8. Whole genome sequencing of fecal samples as a tool for the diagnosis and genetic characterization of norovirus

    NARCIS (Netherlands)

    Bavelaar, Herjan H. J.; Rahamat-Langendoen, Janette; Niesters, Hubert G. M.; Zoll, Jan; Melchers, Willem J. G.

    2015-01-01

    Background: Norovirus is a major cause of gastroenteritis, causing yearly epidemics and hospital outbreaks resulting in a high burden on health care. Detection and characterization of norovirus directly from clinical samples could provide a powerful tool in infection control and norovirus

  9. Fluxing as a new tool for bitumen rheological characterization and the use of time-concentration shift factor (ac)

    CSIR Research Space (South Africa)

    Zoorob, SE

    2018-01-01

    Full Text Available and Building Materials, vol. 158: 691-699 Fluxing as a new tool for bitumen rheological characterization and the use of time-concentration shift factor (ac) Zoorob SE Mturi GA Sangiorgi C Dinis-Almeida M Habib NZ ABSTRACT: The concept...

  10. Machine tool accuracy characterization workshops. Final report, May 5, 1992--November 5 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-01-06

    The ability to assess the accuracy of machine tools is required by both tool builders and users. Builders must have this ability in order to predict the accuracy capability of a machine tool for different part geometry`s, to provide verifiable accuracy information for sales purposes, and to locate error sources for maintenance, troubleshooting, and design enhancement. Users require the same ability in order to make intelligent choices in selecting or procuring machine tools, to predict component manufacturing accuracy, and to perform maintenance and troubleshooting. In both instances, the ability to fully evaluate the accuracy capabilities of a machine tool and the source of its limitations is essential for using the tool to its maximum accuracy and productivity potential. This project was designed to transfer expertise in modern machine tool accuracy testing methods from LLNL to US industry, and to educate users on the use and application of emerging standards for machine tool performance testing.

  11. Innovations in Site Characterization Case Study: Site Cleanup of the Wenatchee Tree Fruit Test Plot Site Using a Dynamic Work Plan

    Science.gov (United States)

    The Wenatchee Tree Fruit Research and Extension Center site contained soils contaminated with organochlorine pesticides, organophosphorus pesticides, and other pesticides due to agriculture-related research activities conducted from 1966 until...

  12. Characterization and monitoring of contaminated sites by multi-geophysical approach (IP, ERT and GPR).

    Science.gov (United States)

    Giampaolo, Valeria; Capozzoli, Luigi; Votta, Mario; Rizzo, Enzo

    2014-05-01

    The contamination of soils and groundwater by hydrocarbons, due to blow out, leakage from tank or pipe and oil spill, is a heavy environmental problem because infiltrated oil can persist in the ground for a long time leading to important changes on soils and physical and biogeochemical properties, which impact on ecosystems and shallow aquifers. The existing methods used for the characterization of hydrocarbon contaminated sites are invasive, time consuming and expensive. Therefore, in the last years, there was a growing interest in the use of geophysical methods for environmental monitoring (Börner et al., 1993; Vanhala, 1997; Atekwana et al., 2000; Chambers et al., 2004; Song et al., 2005; French et al., 2009). The goal of this work is to characterize underground contaminant distributions and monitoring a remediation activity using a multi-geophysical approach (cross-hole IP and ERT, GPR). The experiments consist in geophysical measurements both in surface and boreholes, to monitor a simulated hydrocarbon leachate into a ~1 m3 box. The tank is filled with quartz-rich sand (k = 1.16 x 10-12 m2) and it is equipped with six boreholes and 72 stainless steel ring electrodes, at 5 cm spacing, for cross-hole electrical resistivity and time-domain IP measurements. 25 additional stainless steel electrodes were installed at the surface of the tank. Two measurement phases were realized: first, we monitored electrical resistivity, IP, and dielectric conductivity of the uncontaminated soil; the second experimental phase consists in the geophysical monitoring of a crude oil controlled spill. Results showed significant changes in the responses of geoelectrical measurements in presence of a crude oil contamination. Instead IP results give a phase angle distribution related to the presence of hydrocarbon in the system but not so clear in the location of plume. Therefore, to clearly delineate the areas interested by contamination, we estimate the imaginary component of electrical

  13. Geologic Site Characterization of the North Korean Nuclear Test Site at Punggye-Ri: A Reconnaissance Mapping Redux

    Science.gov (United States)

    2013-11-30

    clandestine nuclear test (e.g., the evaluation of seismic wave propagation, the prediction of gas releases, and evaluation of tunnel layouts). An...produce a high-resolution (5-meter) geologic map of the site. This map helps refine the USGS reconnaissance geology map (which was based on the...test locations, the relationship between fracture rock and containment, and possible motivation for continued tunneling at the â\\”South Portalâ

  14. Structural and biochemical characterization of two heme binding sites on α1-microglobulin using site directed mutagenesis and molecular simulation.

    Science.gov (United States)

    Rutardottir, Sigurbjörg; Karnaukhova, Elena; Nantasenamat, Chanin; Songtawee, Napat; Prachayasittikul, Virapong; Rajabi, Mohsen; Rosenlöf, Lena Wester; Alayash, Abdu I; Åkerström, Bo

    2016-01-01

    α1-Microglobulin (A1M) is a reductase and radical scavenger involved in physiological protection against oxidative damage. These functions were previously shown to be dependent upon cysteinyl-, C34, and lysyl side-chains, K(92, 118,130). A1M binds heme and the crystal structure suggests that C34 and H123 participate in a heme binding site. We have investigated the involvement of these five residues in the interactions with heme. Four A1M-variants were expressed: with cysteine to serine substitution in position 34, lysine to threonine substitutions in positions (92, 118, 130), histidine to serine substitution in position 123 and a wt without mutations. Heme binding was investigated by tryptophan fluorescence quenching, UV-Vis spectrophotometry, circular dichroism, SPR, electrophoretic migration shift, gel filtration, catalase-like activity and molecular simulation. All A1M-variants bound to heme. Mutations in C34, H123 or K(92, 118, 130) resulted in significant absorbance changes, CD spectral changes, and catalase-like activity, suggesting involvement of these side-groups in coordination of the heme-iron. Molecular simulation support a model with two heme-binding sites in A1M involving the mutated residues. Binding of the first heme induces allosteric stabilization of the structure predisposing for a better fit of the second heme. The results suggest that one heme-binding site is located in the lipocalin pocket and a second binding site between loops 1 and 4. Reactions with the hemes involve the side-groups of C34, K(92, 118, 130) and H123. The model provides a structural basis for the functional activities of A1M: heme binding activity of A1M. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Characterization of Hydraulically Significant Discontinuities in Mudrocks at the Waste Control Specialists (WCS) Site, West Texas

    Science.gov (United States)

    Kuszmaul, J. S.; Holt, R. M.; Powers, D. W.; Beauheim, R.; Pickens, J. F.; grisak, G. E.; Hughes, E.; Cook, S.

    2011-12-01

    that showed staining (a possible indicator of past or present hydraulic activity) are rare, vertical to near-vertical, and occur mainly in, and adjacent to, mechanically stiff siltstone and sandstone interbeds. No interconnected fracture networks were observed. A series of pressurized air tests were conducted to evaluate fracture interconnectivity at and below the landfill facilities. Three pairs of vertical and three pairs of inclined boreholes were tested at depths ranging from 40 to 215 feet below ground surface. Borehole packers and volume-displacement tools were placed in each borehole to isolate the injection and observation horizons and minimize borehole storage effects, respectively. Injection pressures ranged from 1 to 5 psig. Pressures within the injection boreholes quickly stabilized and slowly decayed due to porous media flow, while no pressure changes occurred in the observation boreholes. These tests confirm the absence of hydrologically significant fracture networks in the subsurface at the WCS site.

  16. Aespoe HRL - Geoscientific evaluation 1997/2. Results from pre-investigation and detailed site characterization. Summary report

    Energy Technology Data Exchange (ETDEWEB)

    Rhen, I. [VBB Viak, Goeteborg (Sweden); Baeckbom, G. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)] [eds.; Gustafsson, Gunnar [VBB Viak, Goeteborg (Sweden) and Chalmers Univ. of Technology, Goeteborg (Sweden); Stanfors, R. [RS Consulting, Lund (Sweden); Wikberg, P. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)

    1997-05-01

    The work at Aespoe Hard rock laboratory provides an important scientific and technical basis for implementing and operating a future deep repository in Sweden. A milestone has now been reached with the completion of the pre investigation and construction phases at Aespoe HRL. The present data base at Aespoe HRL is one of the most comprehensive data bases in the world for crystalline rock properties, containing data from a large number of investigation methods from the surface down to 1700 m below ground level. Site characterization in conjunction with construction work has basically confirmed the pre-construction models. The site characterization has been a realistic `dress rehearsal` that is invaluable for planning and execution of surface and underground characterization of sites for the deep repository for spent nuclear fuel in Sweden. 502 refs, 114 figs, 30 tabs.

  17. Fractal analysis: A new tool in transient volcanic ash plume characterization.

    Science.gov (United States)

    Tournigand, Pierre-Yves; Peña Fernandez, Juan Jose; Taddeucci, Jacopo; Perugini, Diego; Sesterhenn, Jörn

    2017-04-01

    varying rates. Increasing fractal dimension correspond to an increase in the overall complexity of plume shape and thus to an increase in flow turbulence over time. Accordingly, numerical simulations show that, fractal dimension increases faster with increasing Reynolds number. However, other parameters seem to play a role in volcanic plumes evolution. The features of the eruption source (e.g. vent number, size and shape, ejection duration, number and time interval between the different ejection pulses that characterize unsteady eruptions) seem also to have an effect on this time evolution with for example a single vent source generating a faster increase of the fractal dimension than in the case of a plume fed by several vents over time. This first attempt to use fractal analysis on volcanic plume could be the starting point towards a new kind of tools for volcanic plume characterization potentially giving an access to parameters so far unreachable by only using more traditional techniques. Fractal dimension analysis applied on volcanic plumes could directly link a shape evolution to source conditions and thus help to constrain uncertainties existing on such parameters.

  18. Further characterization of the combining sites of Bandeiraea (Griffonia) simplicifolia lectin-I, isolectin A(4).

    Science.gov (United States)

    Wu, A M; Wu, J H; Chen, Y Y; Song, S C; Kabat, E A

    1999-11-01

    Bandeiraea (Griffonia) simplicifolia lectin-I, isolectin A(4)(GS I-A(4)), which is cytotoxic to the human colon cancer cell lines, is one of two lectin families derived from its seed extract. It contains only a homo-oligomer of subunit A, and is most specific for GalNAcalpha1-->. In order to elucidate the GS I-A(4)-glycoconjugate interactions in greater detail, the combining site of this lectin was further characterized by enzyme linked lectino-sorbent assay (ELLSA) and by inhibition of lectin-glycoprotein interactions. This study has demonstrated that the Tn-containing glycoproteins tested, consisting of mammalian salivary glycoproteins (armadillo, asialo-hamster sublingual, asialo-ovine, -bovine, and -porcine submandibular), are bound strongly by GS I-A(4.)Among monovalent inhibitors so far tested, p-NO2-phenylalphaGalNAc is the most potent, suggesting that hydrophobic forces are important in the interaction of this lectin. GS I-A(4)is able to accommodate the monosaccharide GalNAc at the nonreducing end of oligosaccharides. This suggests that the combining site of the lectin is a shallow cavity. Among oligosaccharides and monosaccharides tested as inhibitors of the binding of GS I-A(4), the hierarchy of potencies are: GalNAcalpha1-->3GalNAcbeta1-->3Galalpha1-->4Galbeta 1-->4Glc (Forssman pentasaccharide) > GalNAcalpha1-->3(LFucalpha1-->2)Gal (blood group A)()> GalNAc > Galalpha1-->4Gal > Galalpha1-->3Gal (blood group B-like)> Gal.

  19. Molecular characterization and patient outcome of melanoma nodal metastases and an unknown primary site.

    Science.gov (United States)

    Gos, Aleksandra; Jurkowska, Monika; van Akkooi, Alexander; Robert, Caroline; Kosela-Paterczyk, Hanna; Koljenović, Senada; Kamsukom, Nyam; Michej, Wanda; Jeziorski, Arkadiusz; Pluta, Piotr; Verhoef, Cornelis; Siedlecki, Janusz A; Eggermont, Alexander M M; Rutkowski, Piotr

    2014-12-01

    Melanoma of unknown primary site (MUP) is not a completely understood entity with nodal metastases as the most common first clinical manifestation. The aim of this multicentric study was to assess frequency and type of oncogenic BRAF/NRAS/KIT mutations in MUP with clinically detected nodal metastases in relation to clinicopathologic features and outcome. We analyzed series of 103 MUP patients (period: 1992-2010) after therapeutic lymphadenectomy (LND): 40 axillary, 47 groin, 16 cervical, none treated with BRAF inhibitors. We performed molecular characterization of BRAF/NRAS/KIT mutational status in nodal metastases using direct sequencing of respective coding sequences. Median follow-up time was 53 months. BRAF mutations were detected in 55 cases (53 %) (51 V600E, 93 %; 4 others, 7 %), and mutually exclusive NRAS mutations were found in 14 cases (14 %) (7 p.Q61R, 4 p.Q61K, 2 p.Q61H, 1 p.Q13R). We have not detected any mutations in KIT. The 5-year overall survival (OS) was 34 %; median was 24 months. We have not found significant correlation between mutational status (BRAF/NRAS) and OS; however, for BRAF or NRAS mutated melanomas we observed significantly shorter disease-free survival (DFS) when compared with wild-type melanoma patients (p = .04; 5-year DFS, 18 vs 19 vs 31 %, respectively). The most important factor influencing OS was number of metastatic lymph nodes >1 (p = .03). Our large study on molecular characterization of MUP with nodal metastases showed that MUPs had molecular features similar to sporadic non-chronic-sun-damaged melanomas. BRAF/NRAS mutational status had negative impact on DFS in this group of patients. These observations might have potential implication for molecular-targeted therapy in MUPs.

  20. Radioactive waste isolation in salt: rationale and methodology for Argonne-conducted reviews of site characterization programs

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, W.; Ditmars, J.D.; Tisue, M.W.; Hambley, D.F.; Fenster, D.F.; Rote, D.M.

    1985-07-01

    Both regulatory and technical concerns must be addressed in Argonne-conducted peer reviews of site characterization programs for individual sites for a high-level radioactive waste repository in salt. This report describes the regulatory framework within which reviews must be conducted and presents background information on the structure and purpose of site characterization programs as found in US Nuclear Regulatory Commission (NRC) Regulatory Guide 4.17 and Title 10, Part 60, of the Code of Federal Regulations. It also presents a methodology to assist reviewers in addressing technical concerns relating to their respective areas of expertise. The methodology concentrates on elements of prime importance to the US Department of Energy's advocacy of a given salt repository system during the NRC licensing process. Instructions are given for reviewing 12 site characterization program elements, starting with performance objectives, performance issues, and levels of performance of repository subsystem components; progressing through performance assessment; and ending with plans for data acquisition and evaluation. The success of a site characterization program in resolving repository performance issues will be determined by judging the likelihood that the proposed data acquisition activities will reduce uncertainties in the performance predictions. 8 refs., 3 figs., 5 tabs.

  1. Screening and characterization of Staphylococcus aureus from ophthalmology clinic surfaces: a proposed surveillance tool

    Science.gov (United States)

    Reem, Rachel E.; Van Balen, Joany; Hoet, Armando E.; Cebulla, Colleen M.

    2014-01-01

    Purpose To screen environmental surfaces of an outpatient ophthalmic clinic for methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MSSA and MRSA); to identify the most commonly contaminated surfaces; and to phenotype and genotype all collected isolates Design A single institution, one-year prospective environmental study Methods Commonly touched surfaces from examination rooms and common areas were targeted and sampled on a quarterly basis for one year. Samples were collected using electrostatic cloths and swabs. S. aureus was isolated using non-selective and selective media. Morphological characteristics and standard biological testing were used to confirm staphylococcal species. S. aureus isolates were phenotypically (Kirby-Bauer method) and genotypically characterized (mecA confirmation, SCCmec typing and pulsed-field gel electrophoresis). Dendrogram analysis was used to establish genetic relatedness between the isolates. Results Of 112 total samples, 27 (24%) and 5 (4%) were MSSA- and MRSA-positive, respectively. Both community-associated (SCCmec IV, USA300) and hospital-associated (SCCmec II, USA100) MRSA isolates were found. No single surface remained consistently positive with the same isolate over time and molecular analysis demonstrated high levels of diversity among isolates. Doorknobs, slit-lamp head/chinrests, and computer keyboards were frequently contaminated. Conclusions The proposed surveillance protocol successfully allowed the detection of both MSSA and MRSA contaminating important high-touch surfaces in a representative ophthalmology clinic. Frequently contaminated surfaces must be targeted for routine cleaning and disinfection as a there is a constant introduction of clones over time. Hence, other clinics may consider implementing and adapting surveillance tools, as the one here described, to help them control these important nosocomial pathogens. PMID:24412125

  2. Utility of Characterizing and Monitoring Suspected Underground Nuclear Sites with VideoSAR

    Science.gov (United States)

    Dauphin, S. M.; Yocky, D. A.; Riley, R.; Calloway, T. M.; Wahl, D. E.

    2016-12-01

    Sandia National Laboratories proposed using airborne synthetic aperture RADAR (SAR) collected in VideoSAR mode to characterize the Underground Nuclear Explosion Signature Experiment (UNESE) test bed site at the Nevada National Security Site (NNSS). The SNL SAR collected airborne, Ku-band (16.8 GHz center frequency), 0.2032 meter ground resolution over NNSS in August 2014 and X-band (9.6 GHz), 0.1016 meter ground resolution fully-polarimetric SAR in April 2015. This paper reports the findings of processing and exploiting VideoSAR for creating digital elevation maps, detecting cultural artifacts and exploiting full-circle polarimetric signatures. VideoSAR collects a continuous circle of phase history data, therefore, imagery can be formed over the 360-degrees of the site. Since the Ku-band VideoSAR had two antennas suitable for interferometric digital elevation mapping (DEM), DEMs could be generated over numerous aspect angles, filling in holes created by targets with height by imaging from all sides. Also, since the X-band VideoSAR was fully-polarimetric, scattering signatures could be gleaned from all angles also. Both of these collections can be used to find man-made objects and changes in elevation that might indicate testing activities. VideoSAR provides a unique, coherent measure of ground objects allowing one to create accurate DEMS, locate man-made objects, and identify scattering signatures via polarimetric exploitation. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. The authors would like to thank the National Nuclear Security Administration, Defense Nuclear Nonproliferation Research and Development, for sponsoring this work. We would also like to thank the Underground Nuclear Explosion Signatures Experiment team, a multi

  3. Characterization of the in vivo sites of serine phosphorylation on Lck identifying serine 59 as a site of mitotic phosphorylation.

    Science.gov (United States)

    Kesavan, Kamala P; Isaacson, Christina C; Ashendel, Curtis L; Geahlen, Robert L; Harrison, Marietta L

    2002-04-26

    The lymphocyte-specific protein-tyrosine kinase Lck plays a critical role in T cell activation. In response to T cell antigen receptor binding Lck undergoes phosphorylation on serine residues that include serines 59 and 194. Serine 59 is phosphorylated by ERK mitogen-activated protein kinase. Recently, we showed that in mitotic T cells Lck becomes hyper-phosphorylated on serine residues. In this report, using one-dimensional phosphopeptide mapping analysis, we identify serine 59 as a site of in vivo mitotic phosphorylation in Lck. The mitotic phosphorylation of serine 59 did not require either the catalytic activity or functional SH2 or SH3 domains of Lck. In addition, the presence of ZAP-70 also was dispensable for the phosphorylation of serine 59. Although previous studies demonstrated that serine 59 is a substrate for the ERK MAPK pathway, inhibitors of this pathway did not block the mitotic phosphorylation of serine 59. These results identify serine 59 as a site of mitotic phosphorylation in Lck and suggest that a pathway distinct from that induced by antigen receptor signaling is responsible for its phosphorylation. Thus, the phosphorylation of serine 59 is the result of two distinct signaling pathways, differentially activated in response to the physiological state of the T cell.

  4. CHARACTERIZING DOE HANFORD SITE WASTE ENCAPSULATION STORAGE FACILITY CELLS USING RADBALL

    Energy Technology Data Exchange (ETDEWEB)

    Farfan, E.; Coleman, R.

    2011-03-31

    RadBall{trademark} is a novel technology that can locate and quantify unknown radioactive hazards within contaminated areas, hot cells, and gloveboxes. The device consists of a colander-like outer tungsten collimator that houses a radiation-sensitive polymer semi-sphere. The collimator has a number of small holes with tungsten inserts; as a result, specific areas of the polymer are exposed to radiation becoming increasingly more opaque in proportion to the absorbed dose. The polymer semi-sphere is imaged in an optical computed tomography scanner that produces a high resolution 3D map of optical attenuation coefficients. A subsequent analysis of the optical attenuation data using a reverse ray tracing or backprojection technique provides information on the spatial distribution of gamma-ray sources in a given area forming a 3D characterization of the area of interest. RadBall{trademark} was originally designed for dry deployments and several tests, completed at Savannah River National Laboratory and Oak Ridge National Laboratory, substantiate its modeled capabilities. This study involves the investigation of the RadBall{trademark} technology during four submerged deployments in two water filled cells at the DOE Hanford Site's Waste Encapsulation Storage Facility.

  5. Magnetic resonance spectral characterization of the heme active site of Coprinus cinereus peroxidase

    Energy Technology Data Exchange (ETDEWEB)

    Lukat, G.S.; Rodgers, K.R.; Jabro, M.N.; Goff, H.M. (Univ. of Iowa, Iowa City (USA))

    1989-04-18

    Examination of the peroxidase isolated from the inkcap Basidiomycete Coprinus cinereus shows that the 42,000-dalton enzyme contains a protoheme IX prosthetic group. Reactivity assays and the electronic absorption spectra of native Coprinus peroxidase and several of its ligand complexes indicate that this enzyme has characteristics similar to those reported for horseradish peroxidase. In this paper, the authors characterize the H{sub 2}O{sub 2}-oxidized forms of Coprinus peroxidase compounds I, II, and III by electronic absorption and magnetic resonance spectroscopies. Electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) studies of this Coprinus peroxidase indicate the presence of high-spin Fe(III) in the native protein and a number of differences between the heme site of Coprinus peroxidase and horseradish peroxidase. Carbon-13 (of the ferrous CO adduct) and nitrogen-15 (of the cyanide complex) NMR studies together with proton NMR studies of the native and cyanide-complexed Caprinus peroxidase are consistent with coordination of a proximal histidine ligand. The EPR spectrum of the ferrous NO complex is also reported. Protein reconstitution with deuterated hemin has facilitated the assignment of the heme methyl resonances in the proton NMR spectrum.

  6. An evaluation tool for assessing performance in priority setting and resource allocation: multi-site application to identify strengths and weaknesses.

    Science.gov (United States)

    Hall, William; Smith, Neale; Mitton, Craig; Gibson, Jennifer; Bryan, Stirling

    2016-01-01

    An evaluation tool should help improve formal priority setting and resource allocation (PSRA) processes in Canada and elsewhere. These are crucial to maximizing value from limited resources. On the basis of case studies, balanced scorecard development protocols and use-focused evaluation principles, an evaluation tool was developed based on an existing framework for high PSRA performance and implemented in two health care organizations in British Columbia, Canada. Implementation of the tool identified areas of strength, improvement and weakness in the pilot organizations' processes for PSRA including: communication, staff engagement and culture. Refinements were identified and incorporated into the tool for future application. This is the first documented multi-site application of such an evaluation tool. Broader dissemination should have use both in further refining the basis of the tool and in catalysing improved performance of PSRA practice. © The Author(s) 2015.

  7. In vivo and in vitro characterization of site-specific recombination of a novel serine integrase from the temperate phage EFC-1

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Bohyun; Kim, Inki; Nam, Ja-Ae [Asan Institute for Life Sciences, Asan Medical Center, College of Medicine, University of Ulsan, 86 Asanbyeoungwon-gil, Songpa-gu, Seoul 138-736 (Korea, Republic of); Chang, Hyo-Ihl [College of Life Sciences & Biotechnology, Korea University, 5-1 Anam-dong, Seongbuk-gu, Seoul 136-701 (Korea, Republic of); Ha, Chang Hoon, E-mail: chhoonha@amc.seoul.kr [Asan Institute for Life Sciences, Asan Medical Center, College of Medicine, University of Ulsan, 86 Asanbyeoungwon-gil, Songpa-gu, Seoul 138-736 (Korea, Republic of)

    2016-04-22

    EFC-1 integrase is a site-specific recombinase that belongs to the large family of serine recombinase. In previously study, we isolated the temperate phage EFC-1, and characterized its genomic sequence. Within its genome, Orf28 was predicted encode a 464 amino acid of a putative integrase gene. In this study, EFC-1 integrase was characterized in vitro and in vivo. In vitro assay was performed using purified His-tag fusion integrase. Also, to identify which serine is involved in the catalytic domain, we used site-directed mutagenesis and analyzed by a recombination assay in vitro. In vivo assay involved PCR and confocal microscopy in HEK293 cells, and determined the minimal lengths of attP and attB sites. According to our results, the EFC-1 integrase-mediated recombination was site-specific and unidirectional system in vitro and in vivo. Serine 21 of EFC-1 integrase plays a major role in the catalytic domain, and minimal sizes of attB and attP was defined 48 and 54 bp. Our finding may help develop a useful tool for gene therapy and gene delivery system. - Highlights: • EFC-1 integrase-mediated recombination was site-specific and unidirectional system. • Serine 21 of EFC-1 integrase plays a major role in the catalytic domain. • The functional minimal sizes of attB and attP was defined 48 and 54 bp.

  8. SITE-94. Geochemical characterization of Simpevarp ground waters near the Aespoe Hard Rock Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Glynn, P.D.; Voss, C.I. [US Geological Survey, Reston, VA (United States)

    1999-09-01

    evidence remains to be found to prove or to disprove that deep penetration of oxygenated ground waters occurred during the last Pleistocene glaciation. Amorphous Fe-oxyhydroxides and goethites have been observed at great depths at several SKB sites in Sweden. These phases may have formed as a result of the intrusion of oxygenated glacial melt waters. The recommendations for future geochemical characterization of potential nuclear waste disposal sites made by the present report generally complement recommendations made earlier by Andrews based on the international program of hydrochemical work at the Stripa mine. In addition to better sampling techniques and protocols, future characterization efforts should place greater emphasis on the measurement of conservative constituents (Cl, Br, {sup 2}H, {sup 18}O) that may provide information on the origin of ground waters and also on the hydrologic disturbances induced by sampling, testing and excavation activities. (abstract truncated)

  9. Mineralogy and geochemistry of the Texeo Cu-Co mine site (NW Spain): screening tools for environmental assessment

    Science.gov (United States)

    Loredo, J.; Álvarez, R.; Ordóñez, A.; Bros, T.

    2008-09-01

    The Cu-Co-Ni Texeo mine has been the most important source of Cu in NW Spain since Roman times and now, approximately 40,000 m3 of wastes from mine and metallurgical operations, containing average concentrations of 9,263 mg kg-1 Cu, 1,100 mg kg-1 As, 549 mg kg-1 Co, and 840 mg kg-1 Ni, remain on-site. Since the cessation of the activity, the abandoned works, facilities and waste piles have been posing a threat to the environment, derived from the release of toxic elements. In order to assess the potential environmental pollution caused by the mining operations, a sequential sampling strategy was undertaken in wastes, soil, surface and groundwater, and sediments. First, screening field tools were used to identify hotspots, before defining formal sampling strategies; so, in the areas where anomalies were detected in a first sampling stage, a second detailed sampling campaign was undertaken. Metal concentrations in the soils are highly above the local background, reaching up to 9,921 mg kg-1 Cu, 1,373 mg kg-1 As, 685 mg kg-1 Co, and 1,040 mg kg-1 Ni, among others. Copper concentrations downstream of the mine works reach values up to 1,869 μg l-1 and 240 mg kg-1 in surface water and stream sediments, respectively. Computer-based risk assessment for the site gives a carcinogenic risk associated with the presence of As in surface waters and soils, and a health risk for long exposures; so, trigger levels of these elements are high enough to warrant further investigation.

  10. Discovery and information-theoretic characterization of transcription factor binding sites that act cooperatively

    CERN Document Server

    Clifford, Jacob

    2015-01-01

    Transcription factor binding to the surface of DNA regulatory regions is one of the primary causes of regulating gene expression levels. A probabilistic approach to model protein-DNA interactions at the sequence level is through Position Weight Matrices (PWMs) that estimate the joint probability of a DNA binding site sequence by assuming positional independence within the DNA sequence. Here we construct conditional PWMs that depend on the motif signatures in the flanking DNA sequence, by conditioning known binding site loci on the presence or absence of additional binding sites in the flanking sequence of each site's locus. Pooling known sites with similar flanking sequence patterns allows for the estimation of the conditional distribution function over the binding site sequences. We apply our model to the Dorsal transcription factor binding sites active in patterning the Dorsal-Ventral axis of Drosophila development. We find that those binding sites that cooperate with nearby Twist sites on average contain a...

  11. Cross validation of geotechnical and geophysical site characterization methods: near surface data from selected accelerometric stations in Crete (Greece)

    Science.gov (United States)

    Loupasakis, C.; Tsangaratos, P.; Rozos, D.; Rondoyianni, Th.; Vafidis, A.; Kritikakis, G.; Steiakakis, M.; Agioutantis, Z.; Savvaidis, A.; Soupios, P.; Papadopoulos, I.; Papadopoulos, N.; Sarris, A.; Mangriotis, M.-D.; Dikmen, U.

    2015-06-01

    The specification of the near surface ground conditions is highly important for the design of civil constructions. These conditions determine primarily the ability of the foundation formations to bear loads, the stress - strain relations and the corresponding settlements, as well as the soil amplification and corresponding peak ground motion in case of dynamic loading. The static and dynamic geotechnical parameters as well as the ground-type/soil-category can be determined by combining geotechnical and geophysical methods, such as engineering geological surface mapping, geotechnical drilling, in situ and laboratory testing and geophysical investigations. The above mentioned methods were combined, through the Thalis ″Geo-Characterization″ project, for the site characterization in selected sites of the Hellenic Accelerometric Network (HAN) in the area of Crete Island. The combination of the geotechnical and geophysical methods in thirteen (13) sites provided sufficient information about their limitations, setting up the minimum tests requirements in relation to the type of the geological formations. The reduced accuracy of the surface mapping in urban sites, the uncertainties introduced by the geophysical survey in sites with complex geology and the 1D data provided by the geotechnical drills are some of the causes affecting the right order and the quantity of the necessary investigation methods. Through this study the gradual improvement on the accuracy of site characterization data is going to be presented by providing characteristic examples from a total number of thirteen sites. Selected examples present sufficiently the ability, the limitations and the right order of the investigation methods.

  12. Characterization of U.S. Wave Energy Converter (WEC) Test Sites: A Catalogue of Met-Ocean Data.

    Energy Technology Data Exchange (ETDEWEB)

    Dallman, Ann Renee; Neary, Vincent Sinclair

    2014-10-01

    This report presents met - ocean data and wave energy characteristics at three U.S. wave energy converter (WEC) test and potential deployment sites . Its purpose is to enable the compari son of wave resource characteristics among sites as well as the select io n of test sites that are most suitable for a developer's device and that best meet their testing needs and objectives . It also provides essential inputs for the design of WEC test devices and planning WEC tests, including the planning of deployment and op eration s and maintenance. For each site, this report catalogues wave statistics recommended in the (draft) International Electrotechnical Commission Technical Specification (IEC 62600 - 101 TS) on Wave Energy Characterization, as well as the frequency of oc currence of weather windows and extreme sea states, and statistics on wind and ocean currents. It also provides useful information on test site infrastructure and services .

  13. Identification and characterization of low mass stars and brown dwarfs using Virtual Observatory tools

    Science.gov (United States)

    Aberasturi, Miriam

    2015-11-01

    Context: Two thirds of the stars in our galactic neighborhood (d building a shortlist with the best possible candidates for exoplanet searches. Brown dwarfs (BDs) are self-gravitating objects that do not get enough mass to maintain a sufficiently high temperature in their core for stable hydrogen fusion. They represent the link between low-mass stars and giant planets. Due to their low temperatures, BDs emit significant flux at mid-infrared wavelength which makes this range very adequate to look for this type of objects. The Virtual Observatory (VO) is an international initiative designed to help the astronomical community in the exploitation of the multi-wavelength information that resides in data archives. In the last years the Spanish Virtual Observatory is conducting a number of projects focused on the study of substellar objects taking advantage of Virtual Observatory tools for an easy data access and analysis of large area surveys. This is the framework where this thesis has been carried out. This dissertation addresses three problems in the framework of low-mass stars and brown dwarfs, namely, the search for brown dwarf candidates crossmatching catalogues (Chapter 4), the search for nearby bright M dwarfs and the subsequent spectroscopic characterization (Chapter 5), and a study of binarity in mid to late-T brown dwarfs (Chapter 6); the first two topics use Virtual Observatory tools. Aims and methodology:In the first paper we carried out a search of brown dwarfs in the sky area in common to the WISE, 2MASS Point Source and SDSS catalogues. A VO-workflow with the criteria that must accomplish our candidates was built using STILTS. The workflow returned 138 sources that were visually inspected. For the six new candidates that passed the inspection, proper motions were calculated using the positions and the different observing epochs of the catalogues previously quoted. Effective temperatures were estimated using VOSA and spectral types and distances using

  14. 10 CFR Appendix IV to Part 960 - Types of Information for the Nomination of Sites as Suitable for Characterization

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Types of Information for the Nomination of Sites as Suitable for Characterization IV Appendix IV to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR... hydraulic properties of aquifers, confining units, and aquitards. • Potential areas and modes of recharge...

  15. Structural characterization of Mg substituted on A/B sites in NiFe2O4 ...

    Indian Academy of Sciences (India)

    2017-06-19

    Jun 19, 2017 ... Home; Journals; Pramana – Journal of Physics; Volume 89; Issue 1. Structural characterization of Mg substituted on A/B sites in N i F e 2 O 4 nanoparticles .... Author Affiliations. MANOJIT DE1 H S TEWARI1. Department of Pure and Applied Physics, Guru Ghasidas Vishwavidyalaya, Bilaspur 495 009, India ...

  16. TECHNICAL APPROACHES TO CHARACTERIZING AND CLEANING UP BROWNFIELDS SITES: PULP AND PAPER MILLS

    Science.gov (United States)

    This guidance document gives assistance to communities, decision-makers, states and municipalities, academia, and the private sector to address issues related to the redevelopment of Brownfields sites, specifically pulp and paper mills sites. The document helps users to understan...

  17. Characterization of osteoarthritis in cats and meloxicam efficacy using objective chronic pain evaluation tools.

    Science.gov (United States)

    Guillot, M; Moreau, M; Heit, M; Martel-Pelletier, J; Pelletier, J-P; Troncy, E

    2013-06-01

    This study aimed to characterize osteoarthritis (OA)-related chronic pain and disability in experimental cats with naturally occurring OA. Peak vertical ground reaction force (PVF), accelerometer-based motor activity (MA) and the von Frey anesthesiometer-induced paw withdrawal threshold were used to define OA and to test the efficacy of meloxicam. A diagnosis of OA was based on radiographic and orthopedic examinations. Cats with OA (n=39) and classified as non-OA (n=6) were used to assess the reliability and sensitivity of the parameters to assess OA over 3weeks while being administered placebo medication. A randomised parallel design study was then used to investigate the effects on OA of daily oral meloxicam treatment for 4weeks at different dose rates (0.025mg/kg, n=10mg/kg; 0.04mg/kg, n=10; 0.05mg/kg, n=9), compared to cats administered a placebo (n=10). The test-retest repeatability for each tool was good (intra-class correlation coefficient ⩾0.6). The PVF and the von Frey anesthesiometer-induced paw withdrawal threshold discriminated OA (PMeloxicam did not add to the PVF improvement observed in placebo-treated cats during the treatment period (adj-P⩽0.01). The 0.025 and the 0.05mg/kg meloxicam-treated cats experienced a higher night-time (17:00-06:58h) MA intensity during the treatment period compared to the placebo period (adj-P=0.04, and 0.02, respectively) and this effect was not observed in the placebo group. The high allodynia rate observed in the 0.04mg/kg meloxicam-treated group may explain the lower responsiveness to the drug. The von Frey anesthesiometer-induced paw withdrawal threshold demonstrated no responsiveness to meloxicam. The results from this study indicated that daily oral meloxicam administration for 4weeks provided pain relief according to night-time MA. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. Comparative Characterization of Atmospheric particles at an urban site and a roadside site in the City of Gaborone, Botswana

    Science.gov (United States)

    Mmereki, B. T.; Khumoetsile, T.

    2016-12-01

    Characterization of individual atmospheric particles in the urban atmosphere is key to addressing a number of air quality issues ranging from pollution source apportionment, understanding their global biogeochemical cycling and environmental fate to the correlation of the particle morphology and chemical make-up to health related issues. Airborne particles were collected in the city of Gaborone Botswana using a High Volume air-sampler. Samples were collected in the summer and winter months at a location bordering a busy highway and a low income high-human population density locality where un-controlled fossil fuel burning provides for the requisite energy requirements of the population in this locality. Morphologies and elemental compositions of particles were obtained using Scanning Electron Microscopy (SEM) coupled with energy-dispersive (X-ray) spectrometry (EDS). Preliminary results suggest a complex mix of aggregates of carbonaceous-diesel particles, complex carbonaceous matter, and inorganic nano-crystals. Ambient air morphology and concentrations of particles (PM10), carbon monoxide (CO), nitrogen oxides (NOx), and ozone (O3) will be discussed. There is a notable influence of high traffic volumes to particle chemistry.

  19. Discovery and information-theoretic characterization of transcription factor binding sites that act cooperatively

    Science.gov (United States)

    Clifford, Jacob; Adami, Christoph

    2015-10-01

    Transcription factor binding to the surface of DNA regulatory regions is one of the primary causes of regulating gene expression levels. A probabilistic approach to model protein-DNA interactions at the sequence level is through position weight matrices (PWMs) that estimate the joint probability of a DNA binding site sequence by assuming positional independence within the DNA sequence. Here we construct conditional PWMs that depend on the motif signatures in the flanking DNA sequence, by conditioning known binding site loci on the presence or absence of additional binding sites in the flanking sequence of each site's locus. Pooling known sites with similar flanking sequence patterns allows for the estimation of the conditional distribution function over the binding site sequences. We apply our model to the Dorsal transcription factor binding sites active in patterning the Dorsal-Ventral axis of Drosophila development. We find that those binding sites that cooperate with nearby Twist sites on average contain about 0.5 bits of information about the presence of Twist transcription factor binding sites in the flanking sequence. We also find that Dorsal binding site detectors conditioned on flanking sequence information make better predictions about what is a Dorsal site relative to background DNA than detection without information about flanking sequence features.

  20. Site Characterization of the Source Physics Experiment Phase II Location Using Seismic Reflection Data

    Science.gov (United States)

    Sexton, E. A.; Snelson, C. M.; Chipman, V.; Emer, D. F.; White, R. L.; Emmitt, R.; Wright, A. A.; Drellack, S.; Huckins-Gang, H.; Mercadante, J.; Floyd, M.; McGowin, C.; Cothrun, C.; Bonal, N.

    2013-12-01

    An objective of the Source Physics Experiment (SPE) is to identify low-yield nuclear explosions from a regional distance. Low-yield nuclear explosions can often be difficult to discriminate among the clutter of natural and man-made explosive events (e.g., earthquakes and mine blasts). The SPE is broken into three phases. Phase I has provided the first of the physics-based data to test the empirical models that have been used to discriminate nuclear events. The Phase I series of tests were placed within a highly fractured granite body. The evolution of the project has led to development of Phase II, to be placed within the opposite end member of geology, an alluvium environment, thereby increasing the database of waveforms to build upon in the discrimination models. Both the granite and alluvium sites have hosted nearby nuclear tests, which provide comparisons for the chemical test data. Phase III of the SPE is yet to be determined. For Phase II of the experiment, characterization of the location is required to develop the geologic/geophysical models for the execution of the experiment. Criteria for the location are alluvium thickness of approximately 170 m and a water table below 170 m; minimal fracturing would be ideal. A P-wave mini-vibroseis survey was conducted at a potential site in alluvium to map out the subsurface geology. The seismic reflection profile consisted of 168 geophone stations, spaced 5 m apart. The mini-vibe was a 7,000-lb peak-force source, starting 57.5 m off the north end of the profile and ending 57.5 m past the southern-most geophone. The length of the profile was 835 m. The source points were placed every 5 m, equally spaced between geophones to reduce clipping. The vibroseis sweep was from 20 Hz down to 180 Hz over 8 seconds, and four sweeps were stacked at each shot location. The shot gathers show high signal-to-noise ratios with clear first arrivals across the entire spread and the suggestion of some shallow reflectors. The data were

  1. Los Alamos National Laboratory Yucca Mountain Site Characterization Project 1992 quality program status report

    Energy Technology Data Exchange (ETDEWEB)

    Bolivar, S.L.; Burningham, A.; Chavez, P. [and others

    1994-03-01

    This status report summarizes the activities and accomplishments of the Los Alamos Yucca Mountain Site Characterization Project`s quality assurance program for calendar year 1992. The report includes major sections on Program Activities and Trend Analysis. Program Activities are discussed periodically at quality meetings. The most significant issue addressed in 1992 has been the timely revision of quality administrative procedures. The procedure revision process was streamlined from 55 steps to 7. The number of forms in procedures was reduced by 38%, and the text reduced by 29%. This allowed revision in 1992 of almost half of all implementing procedures. The time necessary to complete the revision process (for a procedure) was reduced from 11 months to 3 months. Other accomplishments include the relaxation of unnecessarily strict training requirements, requiring quality assurance reviews only from affected organizations, and in general simplifying work processes. All members of the YMP received training to the new Orientation class Eleven other training classed were held. Investigators submitted 971 records to the Project and only 37 were rejected. The software program has 115 programs approved for quality-affecting work. The Project Office conducted 3 audits and 1 survey of Los Alamos activities. We conducted 14 audits and 4 surveys. Eight corrective action reports were closed, leaving only one open. Internally, 22 deficiencies were recognized. This is a decrease from 65 in 1991. Since each deficiency requires about 2 man weeks to resolve, the savings are significant. Problems with writing acceptable deficiency reports have essentially disappeared. Trend reports for 1992 were examined and are summarized herein. Three adverse trends have been closed; one remaining adverse trend will be closed when the affected procedures are revised. The number of deficiencies issued to Los Alamos compared to other participants is minimal.

  2. A strategy to seal exploratory boreholes in unsaturated tuff; Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, J.A. [Sandia National Labs., Albuquerque, NM (United States); Case, J.B.; Givens, C.A.; Carney, B.C. [IT Corp., Albuquerque, NM (United States)

    1994-04-01

    This report presents a strategy for sealing exploratory boreholes associated with the Yucca Mountain Site Characterization Project. Over 500 existing and proposed boreholes have been considered in the development of this strategy, ranging from shallow (penetrating into alluvium only) to deep (penetrating into the groundwater table). Among the comprehensive list of recommendations are the following: Those boreholes within the potential repository boundary and penetrating through the potential repository horizon are the most significant boreholes from a performance standpoint and should be sealed. Shallow boreholes are comparatively insignificant and require only nominal sealing. The primary areas in which to place seals are away from high-temperature zones at a distance from the potential repository horizon in the Paintbrush nonwelded tuff and the upper portion of the Topopah Spring Member and in the tuffaceous beds of the Calico Hills Unit. Seals should be placed prior to waste emplacement. Performance goals for borehole seals both above and below the potential repository are proposed. Detailed construction information on the boreholes that could be used for future design specifications is provided along with a description of the environmental setting, i.e., the geology, hydrology, and the in situ and thermal stress states. A borehole classification scheme based on the condition of the borehole wall in different tuffaceous units is also proposed. In addition, calculations are presented to assess the significance of the boreholes acting as preferential pathways for the release of radionuclides. Design calculations are presented to answer the concerns of when, where, and how to seal. As part of the strategy development, available technologies to seal exploratory boreholes (including casing removal, borehole wall reconditioning, and seal emplacement) are reviewed.

  3. Characterization of dFOXO binding sites upstream of the Insulin Receptor P2 promoter across the Drosophila phylogeny.

    Directory of Open Access Journals (Sweden)

    Dorcas J Orengo

    Full Text Available The insulin/TOR signal transduction pathway plays a critical role in determining such important traits as body and organ size, metabolic homeostasis and life span. Although this pathway is highly conserved across the animal kingdom, the affected traits can exhibit important differences even between closely related species. Evolutionary studies of regulatory regions require the reliable identification of transcription factor binding sites. Here we have focused on the Insulin Receptor (InR expression from its P2 promoter in the Drosophila genus, which in D. melanogaster is up-regulated by hypophosphorylated Drosophila FOXO (dFOXO. We have finely characterized this transcription factor binding sites in vitro along the 1.3 kb region upstream of the InR P2 promoter in five Drosophila species. Moreover, we have tested the effect of mutations in the characterized dFOXO sites of D. melanogaster in transgenic flies. The number of experimentally established binding sites varies across the 1.3 kb region of any particular species, and their distribution also differs among species. In D. melanogaster, InR expression from P2 is differentially affected by dFOXO binding sites at the proximal and distal halves of the species 1.3 kb fragment. The observed uneven distribution of binding sites across this fragment might underlie their differential contribution to regulate InR transcription.

  4. Positronics of subnanometer atomistic imperfections in solids as a high-informative structure characterization tool

    National Research Council Canada - National Science Library

    Shpotyuk, Oleh; Filipecki, Jacek; Ingram, Adam; Golovchak, Roman; Vakiv, Mykola; Klym, Halyna; Balitska, Valentyna; Shpotyuk, Mykhaylo; Kozdras, Andrzej

    2015-01-01

    Methodological possibilities of positron annihilation lifetime (PAL) spectroscopy applied to characterize different types of nanomaterials treated within three-term fitting procedure are critically reconsidered...

  5. APROBA-Plus: A probabilistic tool to evaluate and express uncertainty in hazard characterization and exposure assessment of substances.

    Science.gov (United States)

    Bokkers, Bas G H; Mengelers, Marcel J; Bakker, Martine I; Chiu, Weihsueh A; Slob, Wout

    2017-12-01

    To facilitate the application of probabilistic risk assessment, the WHO released the APROBA tool. This tool applies lognormal uncertainty distributions to the different aspects of the hazard characterization, resulting in a probabilistic health-based guidance value. The current paper describes an extension, APROBA-Plus, which combines the output from the probabilistic hazard characterization with the probabilistic exposure to rapidly characterize risk and its uncertainty. The uncertainty in exposure is graphically compared with the uncertainty in the target human dose, i.e. the dose that complies with the specified protection goals. APROBA-Plus is applied to several case studies, resulting in distinct outcomes and illustrating that APROBA-Plus could serve as a standard extension of routine risk assessments. By visualizing the uncertainties, APROBA-Plus provides a more transparent and informative outcome than the more usual deterministic approaches, so that risk managers can make better informed decisions. For example, APROBA-Plus can help in deciding whether risk-reducing measures are warranted or that a refined risk assessment would first be needed. If the latter, the tool can be used to prioritize possible refinements. APROBA-Plus may also be used to rank substances into different risk categories, based on potential health risks without being compromised by different levels of conservatism that may be associated with point estimates of risk. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Vis-NIR characterization of particulate matter in urban and industrial sites in the Mediterranean area

    Science.gov (United States)

    Salzano, R.; Montagnoli, M.; Salvatori, R.; Perrino, C.

    2010-12-01

    The optical properties of particulate matter are key parameters for the definition of the radiative balance of the atmosphere and require a deeper comprehension for improving modelling. Considering the cognitive gap evidenced by IPCC guidelines, additional tools are necessary for understanding how size distribution and mineralogy contribute to the complexity of a matrix such as particulate matter. Knowing that concentration and chemical composition are nowadays features that are “traditionally” investigated, the role of mineralogy and size distribution on the physico-chemical behaviour of airborne particles represent evidently primary goals for emerging approaches. From this point of view Vis-NIR spectroscopy could be considered an innovative technique. It is in fact a non-destructive and a relatively low-cost technique that provide information on the optical properties of materials. It is largely applied for Earth sciences purposes (for example: Pedology, Geology and Remote sensing) and requires a “calibration” with chemical or physical parameters. The difference between this technique and already developed methods (such as Aethalometry or other optical systems) consists on the simultaneous investigation of several wavelengths of the visible and near infrared regions instead of single bands. The development of this approach, focused on the relationship between light scattering and properties of materials, can provide important knowledge on the mineralogical composition of airborne particles and on the size distribution of particles. In addition of that the development of a database, constituted by airborne materials collected in different sites, can represent the link between remote or ground observations, radiative modelling and in situ sampling. The work carried out until now is based on field campaigns performed in the Mediterranean basin where PM10 and PM2.5 samples were collected in urban, traffic, industrial and background sites. Samples were

  7. Geotechnical characterization of the North Ramp of the Exploratory Studies Facility: Yucca Mountain Site Characterization Project. Volume 2, NRG corehole data appendices

    Energy Technology Data Exchange (ETDEWEB)

    Brechtel, C.E.; Lin, Ming; Martin, E. [Agapito Associates, Inc., Grand Junction, CO (United States); Kessel, D.S. [Sandia National Labs., Albuquerque, NM (United States)

    1995-05-01

    This report presents the results of the geological and geotechnical characterization of the Miocene volcanic tuff rocks of the Timber Mountain and Paintbrush groups that the tunnel boring machine will encounter during excavations of the Exploratory Studies Facility (ESF) North Ramp. The information in this report was developed to support the design of the ESF North Ramp. The ESF is being constructed by the DOE as part of the Yucca Mountain Project site characterization activities. The purpose of these activities is to evaluate the potential to locate the national high-level nuclear waste repository on land within and adjacent to the Nevada Test Site (NTS), Nye County, Nevada. This report was prepared as part of the Soil and Rock Properties Studies in accordance with the 8.3.1.14.2 Study Plan to Provide Soil and Rock Properties. This is volume 2 which contains NRG Corehole Data for each of the NRG Holes.

  8. Evaluation of the effects of underground water usage and spillage in the Exploratory Studies Facility; Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, E.; Sobolik, S.R.

    1993-12-01

    The Yucca Mountain Site Characterization Project is studying Yucca Mountain in southwestern Nevada as a potential site for a high-level radioactive waste repository. Analyses reported herein were performed to support the design of site characterization activities so that these activities will have a minimal impact on the ability of the site to isolate waste and a minimal impact on underground tests performed as part of the characterization process. These analyses examine the effect of water to be used in the underground construction and testing activities for the Exploratory Studies Facility on in situ conditions. Underground activities and events where water will be used include construction, expected but unplanned spills, and fire protection. The models used predict that, if the current requirements in the Exploratory Studies Facility Design Requirements are observed, water that is imbibed into the tunnel wall rock in the Topopah Springs welded tuff can be removed over the preclosure time period by routine or corrective ventilation, and also that water imbibed into the Paintbrush Tuff nonwelded tuff will not reach the potential waste storage area.

  9. Methods to characterize environmental settings of stream and groundwater sampling sites for National Water-Quality Assessment

    Science.gov (United States)

    Nakagaki, Naomi; Hitt, Kerie J.; Price, Curtis V.; Falcone, James A.

    2012-01-01

    Characterization of natural and anthropogenic features that define the environmental settings of sampling sites for streams and groundwater, including drainage basins and groundwater study areas, is an essential component of water-quality and ecological investigations being conducted as part of the U.S. Geological Survey's National Water-Quality Assessment program. Quantitative characterization of environmental settings, combined with physical, chemical, and biological data collected at sampling sites, contributes to understanding the status of, and influences on, water-quality and ecological conditions. To support studies for the National Water-Quality Assessment program, a geographic information system (GIS) was used to develop a standard set of methods to consistently characterize the sites, drainage basins, and groundwater study areas across the nation. This report describes three methods used for characterization-simple overlay, area-weighted areal interpolation, and land-cover-weighted areal interpolation-and their appropriate applications to geographic analyses that have different objectives and data constraints. In addition, this document records the GIS thematic datasets that are used for the Program's national design and data analyses.

  10. Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites

    DEFF Research Database (Denmark)

    Julenius, Karin; Mølgaard, Anne; Gupta, Ramneek

    2004-01-01

    than a nonglycosylated one. The Protein Data Bank was analyzed for structural information, and 12 glycosylated structures were obtained. All positive sites were found in coil or turn regions. A method for predicting the location for mucin-type glycosylation sites was trained using a neural network...... approach. The best overall network used as input amino acid composition, averaged surface accessibility predictions together with substitution matrix profile encoding of the sequence. To improve prediction on isolated (single) sites, networks were trained on isolated sites only. The final method combines...

  11. Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites

    DEFF Research Database (Denmark)

    Julenius, Karin; Mølgaard, Anne; Gupta, Ramneek

    2005-01-01

    than a nonglycosylated one. The Protein Data Bank was analyzed for structural information, and 12 glycosylated structures were obtained. All positive sites were found in coil or turn regions. A method for predicting the location for mucin-type glycosylation sites was trained using a neural network...... approach. The best overall network used as input amino acid composition, averaged surface accessibility predictions together with substitution matrix profile encoding of the sequence. To improve prediction on isolated (single) sites, networks were trained on isolated sites only. The final method combines...

  12. Noninvasive characterization of the Trecate (Italy) crude-oil contaminated site: links between contamination and geophysical signals.

    Science.gov (United States)

    Cassiani, Giorgio; Binley, Andrew; Kemna, Andreas; Wehrer, Markus; Orozco, Adrian Flores; Deiana, Rita; Boaga, Jacopo; Rossi, Matteo; Dietrich, Peter; Werban, Ulrike; Zschornack, Ludwig; Godio, Alberto; JafarGandomi, Arash; Deidda, Gian Piero

    2014-01-01

    The characterization of contaminated sites can benefit from the supplementation of direct investigations with a set of less invasive and more extensive measurements. A combination of geophysical methods and direct push techniques for contaminated land characterization has been proposed within the EU FP7 project ModelPROBE and the affiliated project SoilCAM. In this paper, we present results of the investigations conducted at the Trecate field site (NW Italy), which was affected in 1994 by crude oil contamination. The less invasive investigations include ground-penetrating radar (GPR), electrical resistivity tomography (ERT), and electromagnetic induction (EMI) surveys, together with direct push sampling and soil electrical conductivity (EC) logs. Many of the geophysical measurements were conducted in time-lapse mode in order to separate static and dynamic signals, the latter being linked to strong seasonal changes in water table elevations. The main challenge was to extract significant geophysical signals linked to contamination from the mix of geological and hydrological signals present at the site. The most significant aspects of this characterization are: (a) the geometrical link between the distribution of contamination and the site's heterogeneity, with particular regard to the presence of less permeable layers, as evidenced by the extensive surface geophysical measurements; and (b) the link between contamination and specific geophysical signals, particularly evident from cross-hole measurements. The extensive work conducted at the Trecate site shows how a combination of direct (e.g., chemical) and indirect (e.g., geophysical) investigations can lead to a comprehensive and solid understanding of a contaminated site's mechanisms.

  13. Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates.

    Science.gov (United States)

    Botzanowski, Thomas; Erb, Stéphane; Hernandez-Alba, Oscar; Ehkirch, Anthony; Colas, Olivier; Wagner-Rousset, Elsa; Rabuka, David; Beck, Alain; Drake, Penelope M; Cianférani, Sarah

    2017-07-01

    Antibody-drug conjugates (ADCs) have emerged as a family of compounds with promise as efficient immunotherapies. First-generation ADCs were generated mostly via reactions on either lysine side-chain amines or cysteine thiol groups after reduction of the interchain disulfide bonds, resulting in heterogeneous populations with a variable number of drug loads per antibody. To control the position and the number of drug loads, new conjugation strategies aiming at the generation of more homogeneous site-specific conjugates have been developed. We report here the first multi-level characterization of a site-specific ADC by state-of-the-art mass spectrometry (MS) methods, including native MS and its hyphenation to ion mobility (IM-MS). We demonstrate the versatility of native MS methodologies for site-specific ADC analysis, with the unique ability to provide several critical quality attributes within one single run, along with a direct snapshot of ADC homogeneity/heterogeneity without extensive data interpretation. The capabilities of native IM-MS to directly access site-specific ADC conformational information are also highlighted. Finally, the potential of these techniques for assessing an ADC's heterogeneity/homogeneity is illustrated by comparing the analytical characterization of a site-specific DAR4 ADC to that of first-generation ADCs. Altogether, our results highlight the compatibility, versatility, and benefits of native MS approaches for the analytical characterization of all types of ADCs, including site-specific conjugates. Thus, we envision integrating native MS and IM-MS approaches, even in their latest state-of-the-art forms, into workflows that benchmark bioconjugation strategies.

  14. Characterization report for Area 23, Building 650 Leachfield, Corrective Action Unit Number 94, Nevada Test Site. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-27

    Corrective Action Unit (CAU) Number 94, Building 650 Leachfield, is an historic laboratory disposal unit located in Area 23 at the Nevada Test Site (NTS) in Nye County, Nevada. The objectives of this project were twofold: characterize subsurface conditions at the CAU with respect to the on-site disposal unit, and provide sufficient information to develop a closure strategy for the leachfield. To this end, subsurface sampling was conducted in the vicinity of the piping above the distribution box, under and around the distribution box, and within the leachfield.

  15. DEVELOPMENT AND APPLICATION OF A FAST-RUNNING TOOL TO CHARACTERIZE SHOCK DAMAGE WITHIN TUNNEL STRUCTURES

    Energy Technology Data Exchange (ETDEWEB)

    Glascoe, L; Morris, J; Glenn, L; Krnjajic, M

    2009-03-31

    Successful but time-intensive use of high-fidelity computational capabilities for shock loading events and resultant effects on and within enclosed structures, e.g., tunnels, has led to an interest in developing more expedient methods of analysis. While several tools are currently available for the general study of the failure of structures under dynamic shock loads at a distance, presented are a pair of statistics- and physics-based tools that can be used to differentiate different types of damage (e.g., breach versus yield) as well as quantify the amount of damage within tunnels for loads close-in and with standoff. Use of such faster running tools allows for scoping and planning of more detailed model and test analysis and provides a way to address parametric sensitivity over a large multivariate space.

  16. Regional hydrogeological simulations for Forsmark - numerical modelling using DarcyTools. Preliminary site description Forsmark area version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-12-15

    A numerical model is developed on a regional-scale (hundreds of square kilometres) to study the zone of influence for variable-density groundwater flow that affects the Forsmark area. Transport calculations are performed by particle tracking from a local-scale release area (a few square kilometres) to test the sensitivity to different hydrogeological uncertainties and the need for far-field realism. The main objectives of the regional flow modelling were to achieve the following: I. Palaeo-hydrogeological understanding: An improved understanding of the palaeohydrogeological conditions is necessary in order to gain credibility for the site descriptive model in general and the hydrogeological description in particular. This requires modelling of the groundwater flow from the last glaciation up to present-day with comparisons against measured TDS and other hydro-geochemical measures. II. Simulation of flow paths: The simulation and visualisation of flow paths from a tentative repository area is a means for describing the role of the current understanding of the modelled hydrogeological conditions in the target volume, i.e. the conditions of primary interest for Safety Assessment. Of particular interest here is demonstration of the need for detailed far-field realism in the numerical simulations. The motivation for a particular model size (and resolution) and set of boundary conditions for a realistic description of the recharge and discharge connected to the flow at repository depth is an essential part of the groundwater flow path simulations. The numerical modelling was performed by two separate modelling teams, the ConnectFlow Team and the DarcyTools Team. The work presented in this report was based on the computer code DarcyTools developed by Computer-aided Fluid Engineering. DarcyTools is a kind of equivalent porous media (EPM) flow code specifically designed to treat flow and salt transport in sparsely fractured crystalline rock intersected by transmissive

  17. Topographic gradient based site characterization in India complemented by strong ground-motion spectral attributes

    KAUST Repository

    Nath, Sankar Kumar

    2013-12-01

    We appraise topographic-gradient approach for site classification that employs correlations between 30. m column averaged shear-wave velocity and topographic gradients. Assessments based on site classifications reported from cities across India indicate that the approach is reasonably viable at regional level. Additionally, we experiment three techniques for site classification based on strong ground-motion recordings, namely Horizontal-to-Vertical Spectral Ratio (HVSR), Response Spectra Shape (RSS), and Horizontal-to-Vertical Response Spectral Ratio (HVRSR) at the strong motion stations located across the Himalayas and northeast India. Statistical tests on the results indicate that these three techniques broadly differentiate soil and rock sites while RSS and HVRSR yield better signatures. The results also support the implemented site classification in the light of strong ground-motion spectral attributes observed in different parts of the globe. © 2013 Elsevier Ltd.

  18. Synthesis and Preliminary Characterization of a PPE-Type Polymer Containing Substituted Fullerenes and Transition Metal Ligation Sites

    Directory of Open Access Journals (Sweden)

    Corinne A. Basinger

    2015-01-01

    Full Text Available A substituted fullerene was incorporated into a PPE-conjugated polymer repeat unit. This subunit was then polymerized via Sonogashira coupling with other repeat units to create polymeric systems approaching 50 repeat units (based on GPC characterization. Bipyridine ligands were incorporated into some of these repeat units to provide sites for transition metal coordination. Photophysical characterization of the absorption and emission properties of these systems shows excited states located on both the fullerene and aromatic backbone of the polymers that exist in a thermally controlled equilibrium. Future work will explore other substituted polyaromatic systems using similar methodologies.

  19. Photogrammetry surveys and mosaic: a useful tool to monitor active zones. Applications to the Indonesian Lusi eruption site.

    Science.gov (United States)

    Romeo, Giovanni; Di Stefano, Giuseppe; Mazzini, Adriano; Iarocci, Alessandro; Caramelli, Antonio

    2016-04-01

    Unmanned and remotely operated aircraft showed to be an efficient and cost effective way to explore remote or extreme environments. Comparative photogrammetry studies are an efficient way to study and monitor he evolution of geologically active areas and ongoing events and are able to highlight details that are typically lost during traditional field campaigns. The Lusi mud eruption in eastern Java (Indonesia) represents one of the most spectacular geological phenomena that is ongoing since May 2006. In the framework of the Lusi Lab project (ERC grant n° 308126) we designed and constructed a multipurpose drone to survey the eruption site. Among the numerous other payloads, the Lusi drone is equipped with Olympus EPM-2 and Go-Pro Hero3 cameras that allow the operator to collect video stills, high quality pictures and to complete photogrammetry surveys. Targeted areas have been selected for detailed studies in the 7 km2 region inside the embankment that was prevent the mud burial of the settlements in the Sidoarjo Regency. The region is characterized by the presence of the Watukosek fault zone. This strike slip system originates from the Arjuno-Welirang volcanic complex and extends to the north east of the Java Island intersecting the Lusi crater. Therefore of particular interest are the faulted surveyed areas present around the Lusi crater inside the embankment. Results reveal a surprising accuracy for the collected mosaic. Multiple surveys are able to reveal the changes and the evolution of the fault through time and to indicate more active zones. In particular this type of survey can highlight the weakness zones and is thus useful to prevent potential geohazards in the area. The poster shows the aerial survey results, including a 3d-printed slice of LuSi, obtained combining 2500 16 Mp photographs. A 3d zoomed detail is also shown, evidencing the resolution that this technique can offer.

  20. Spatial characterization and prediction of Neanderthal sites based on environmental information and stochastic modelling

    Science.gov (United States)

    Maerker, Michael; Bolus, Michael

    2014-05-01

    We present a unique spatial dataset of Neanderthal sites in Europe that was used to train a set of stochastic models to reveal the correlations between the site locations and environmental indices. In order to assess the relations between the Neanderthal sites and environmental variables as described above we applied a boosted regression tree approach (TREENET) a statistical mechanics approach (MAXENT) and support vector machines. The stochastic models employ a learning algorithm to identify a model that best fits the relationship between the attribute set (predictor variables (environmental variables) and the classified response variable which is in this case the types of Neanderthal sites. A quantitative evaluation of model performance was done by determining the suitability of the model for the geo-archaeological applications and by helping to identify those aspects of the methodology that need improvements. The models' predictive performances were assessed by constructing the Receiver Operating Characteristics (ROC) curves for each Neanderthal class, both for training and test data. In a ROC curve the Sensitivity is plotted over the False Positive Rate (1-Specificity) for all possible cut-off points. The quality of a ROC curve is quantified by the measure of the parameter area under the ROC curve. The dependent variable or target variable in this study are the locations of Neanderthal sites described by latitude and longitude. The information on the site location was collected from literature and own research. All sites were checked for site accuracy using high resolution maps and google earth. The study illustrates that the models show a distinct ranking in model performance with TREENET outperforming the other approaches. Moreover Pre-Neanderthals, Early Neanderthals and Classic Neanderthals show a specific spatial distribution. However, all models show a wide correspondence in the selection of the most important predictor variables generally showing less

  1. Characterization of the geology, geochemistry, hydrology and microbiology of the in-situ air stripping demonstration site at the Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Eddy, C.A.; Looney, B.B.; Dougherty, J.M.; Hazen, T.C.; Kaback, D.S.

    1991-05-01

    The Savannah River Site is the location of an Integrated Demonstration Project designed to evaluate innovative remediation technologies for environmental restoration at sites contaminated with volatile organic contaminants. This demonstration utilizes directionally drilled horizontal wells to deliver gases and extract contaminants from the subsurface. Phase I of the Integrated Demonstration focused on the application and development of in-situ air stripping technologies to remediate soils and sediments above and below the water table as well as groundwater contaminated with volatile organic contaminants. The objective of this report is to provide baseline information on the geology, geochemistry, hydrology, and microbiology of the demonstration site prior to the test. The distribution of contaminants in soils and sediments in the saturated zone and groundwater is emphasized. These data will be combined with data collected after the demonstration in order to evaluate the effectiveness of in-situ air stripping. New technologies for environmental characterization that were evaluated include depth discrete groundwater sampling (HydroPunch) and three-dimensional modeling of contaminant data.

  2. Preliminary recommendations on the design of the characterization program for the Hanford Site single-shell tanks: A system analysis

    Energy Technology Data Exchange (ETDEWEB)

    Buck, J.W.; Peffers, M.S.; Hwang, S.T.

    1991-11-01

    The work described in this volume was conducted by Pacific Northwest Laboratory to provide preliminary recommendations on data quality objectives (DQOs) to support the Waste Characterization Plan (WCP) and closure decisions for the Hanford Site single-shell tanks (SSTs). The WCP describes the first of a two-phase characterization program that will obtain information to assess and implement disposal options for SSTs. This work was performed for the Westinghouse Hanford Company (WHC), the current operating contractor on the Hanford Site. The preliminary DQOs contained in this volume deal with the analysis of SST wastes in support of the WCP and final closure decisions. These DQOs include information on significant contributors and detection limit goals (DLGs) for SST analytes based on public health risk.

  3. Characterization of Tool Wear in High-Speed Milling of Hardened Powder Metallurgical Steels

    Directory of Open Access Journals (Sweden)

    Fritz Klocke

    2011-01-01

    Full Text Available In this experimental study, the cutting performance of ball-end mills in high-speed dry-hard milling of powder metallurgical steels was investigated. The cutting performance of the milling tools was mainly evaluated in terms of cutting length, tool wear, and cutting forces. Two different types of hardened steels were machined, the cold working steel HS 4-2-4 PM (K490 Microclean/66 HRC and the high speed steel HS 6-5-3 PM (S790 Microclean/64 HRC. The milling tests were performed at effective cutting speeds of 225, 300, and 400 m/min with a four fluted solid carbide ball-end mill (0 = 6, TiAlN coating. It was observed that by means of analytically optimised chipping parameters and increased cutting speed, the tool life can be drastically enhanced. Further, in machining the harder material HS 4-2-4 PM, the tool life is up to three times in regard to the less harder material HS 6-5-3 PM. Thus, it can be assumed that not only the hardness of the material to be machined plays a vital role for the high-speed dry-hard cutting performance, but also the microstructure and thermal characteristics of the investigated powder metallurgical steels in their hardened state.

  4. Characterization of volatile sulphur compounds production at individual gingival crevicular sites in humans.

    Science.gov (United States)

    Coli, J M; Tonzetich, J

    1992-01-01

    The present investigation describes a method for collection and analysis of volatile sulphur compounds (VSC) from gingival crevicular sites in humans. Tenax-GC trapping devices were used to adsorb and concentrate VSC from crevicular air at -55 degrees C, which were then thermally desorbed at 120 degrees C. Gas chromatographic (GC) analyses were performed using a Tracor 550 GC equipped with a flame-photometric detector and a Teflon column packed with 5% polyphenyl ether and 0.05% phosphoric acid on 30-40 mesh Teflon. Sulfides identified from crevicular sites include hydrogen sulfide [H2S], methyl mercaptan [CH3SH], dimethyl sulfide [(CH3)2S], and dimethyl disulfide [(CH3S)2]. Of the seventeen patients studied, crevicular sites that were either deep (P.D. > or = 4 mm) or inflamed (BoP = 1) exhibited significantly larger CH3SH to H2S ratios than corresponding crevicular shallow (P.D. < or = 3 mm) sites (p < .10) or noninflamed (BoP = 0) sites (p < .05). Similarly, total sulphur in deep and inflamed sites was significantly higher than in corresponding shallow (p < .01) and noninflamed (p < .05) sites. This is the first known in vivo study to quantitate VSC directly from individual gingival crevices.

  5. Characterization and evaluation of sites for deep geological disposal of radioactive waste in fractured rocks. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    The third Aespoe International Seminar was organised by SKB to assess the state of the art in characterisation and evaluation of sites for deep geological disposal of radioactive waste in fractured rocks. Site characterisation and evaluation are important elements for determining the site suitability and long-term safety of a geological repository for radioactive waste disposal. Characterisation work also provides vital information for the design of the underground facility and the engineered barrier system that will contain the waste. The aim of the seminar was to provide a comprehensive assessment of the current know-how on this topic based on world-wide experience from more than 20 years of characterisation and evaluation work. The seminar, which was held at the Aespoe Hard Rock Laboratory was attended by 72 scientists from 10 different countries. The program was divided into four sessions of which two were run in parallel. A total of 38 oral and 5 poster presentations were given at the seminar. The presentations gave a comprehensive summary of recently completed and current work on site characterisation, modelling and application in performance assessments. The results presented at the seminar generally show that significant progress has been made in this field during the last decade. New characterisation techniques have become available, strategies for site investigations have developed further, and model concepts and codes have reached new levels of refinement. Data obtained from site characterisation have also successfully been applied in several site specific performance assessments. The seminar clearly showed that there is a solid scientific basis for assessing the suitability of sites for actual repositories based on currently available site characterisation technology and modelling capabilities. Separate abstracts have been prepared for 38 of the presentations

  6. Characterization of a novel /sup 3/H-5-hydroxytryptamine binding site subtype in bovine brain membranes

    Energy Technology Data Exchange (ETDEWEB)

    Heuring, R.E.; Peroutka, S.J.

    1987-03-01

    /sup 3/H-5-Hydroxytryptamine (5-HT) binding sites were analyzed in bovine brain membranes. The addition of either the 5-HT1A-selective drug 8-OH-DPAT (100 nM) or the 5-HT1C-selective drug mesulergine (100 nM) to the assay resulted in a 5-10% decrease in specific /sup 3/H-5-HT binding. Scatchard analysis revealed that the simultaneous addition of both drugs decreased the Bmax of /sup 3/H-5-HT binding by 10-15% without affecting the KD value (1.8 +/- 0.3 nM). Competition studies using a series of pharmacologic agents revealed that the sites labeled by /sup 3/H-5-HT in bovine caudate in the presence of 100 nM 8-OH-DPAT and 100 nM mesulergine appear to be homogeneous. 5-HT1A selective agents such as 8-OH-DPAT, ipsapirone, and buspirone display micromolar affinities for these sites. RU 24969 and (-)pindolol are approximately 2 orders of magnitude less potent at these sites than at 5-HT1B sites which have been identified in rat brain. Agents displaying nanomolar potencies for 5-HT1C sites such as mianserin and mesulergine are 2-3 orders of magnitude less potent at the /sup 3/H-5-HT binding sites in bovine caudate. In addition, both 5-HT2- and 5-HT3-selective agents are essentially inactive at these binding sites. These /sup 3/H-5-HT sites display nanomolar affinity for 5-carboxyamidotryptamine, 5-methoxytryptamine, metergoline, and 5-HT. Apparent Ki values of 10-100 nM are obtained for d-LSD, RU 24969, methiothepin, tryptamine, methysergide, and yohimbine, whereas I-LSD and corynanthine are significantly less potent. In addition, these /sup 3/H-5-HT labeled sites are regulated by guanine nucleotides and calcium. Regional studies indicate that this class of sites is most dense in the basal ganglia but exists in all regions of bovine brain. These data therefore demonstrate the presence of a homogeneous class of 5-HT1 binding sites in bovine caudate that is pharmacologically distinct from previously defined 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2, and 5-HT3 receptor subtypes

  7. Application of PIXE to the characterization of vitreous dacites from archaeolgical sites in the Atacama region in northern Chile

    Energy Technology Data Exchange (ETDEWEB)

    Morales, J.R.; Cancino, S. [Departamento de Fisica, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Nunoa, Santiago 1 (Chile); Miranda, P. [Departamento de Fisica, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Nunoa, Santiago 1 (Chile)], E-mail: pjmirand@gmail.com; Dinator, M.I. [Departamento de Fisica, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Nunoa, Santiago 1 (Chile); Seelenfreund, A. [Universidad Academia de Humanismo Cristiano, Condell 343, Providencia, Santiago (Chile)

    2007-11-15

    Geochemical characterization studies using PIXE were carried out on 21 vitreous dacite artifacts from early formative archaeological sites in the Atacama region, in northern Chile, and on 13 samples taken from two potential volcanic sources located within the region. Performing statistical analyses it was possible to obtain elemental concentration patterns for the archaeological samples of this material and match some of these artifacts with the geological source samples.

  8. Characterization and reclamation assessment for the Central Shops Diesel Storage Facility, Savannah River Site, Aiken, South Carolina

    Energy Technology Data Exchange (ETDEWEB)

    Fliermans, C.B.; Hazen, T.C.; Bledsoe, H.

    1993-10-01

    The contamination of subsurface terrestrial environments by organic contaminants is a global phenomenon. The remediation of such environments requires innovative assessment techniques and strategies for successful clean-ups. Central Shops Diesel Storage Facility at Savannah River Site was characterized to determine the extent of subsurface diesel fuel contamination using innovative approaches and effective bioremediation techniques for clean-up of the contaminant plume have been established.

  9. Characterization of chlorophyll-a over CAL-VAL site at Kavaratti in the Lakshadweep Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Babu, K.N; Shukla, A; Matondkar, S.G.P.; Singh, S.K.; Sawant, S.S.

    Under the Meteorology and Oceanography Programme (MOP) of the Indian Space Research Organization (ISRO), a Calibration-Validation site is planned at Kavaratti in the Lakshadweep Sea with a pair of moored data buoys consisting of fully programmed...

  10. CHARACTERIZING POPULATIONS OF THE ESTUARINE FISH FUNDULUS HETEROCLITUS INDIGENOUS TO SITES WITH DIFFERING ENVIRONMENTAL QUALITY

    Science.gov (United States)

    Populations of the non-migratory estuarine fish Fundulus heteroclitus were collected from New Bedford Harbor and distant clean sites to investigate whether indigenous populations have adapted genetically to the harbor's contamination. New Bedford Harbor, a major port in southe...

  11. Site characterization using noninvasive single- and multi-station methods at southern California seismic stations

    Science.gov (United States)

    Yong, A.; Martin, A. J.; Pfau, J.; McPhillips, D.; Alvarez, M.; Lydeen, S.; Clerc, F.; Leue, N.

    2016-12-01

    In-situ measurements of shear-wave velocity (Vs) are used commonly to evaluate seismic response at earthquake monitoring station and project sites. Vs30, the time-averaged Vs in the upper 30 m, is a common parameter used to capture seismic site response and is used in almost all modern ground motion prediction equations. Traditional invasive downhole methods directly measure Vs; however, these methods are often cost- and/or environmentally-prohibitive and their results do not always reflect the lateral variability of seismic conditions beyond the immediate vicinity of the test site. In comparison, noninvasive methods record active- or passive-source data consisting of surface or body waves and are less prohibitive to use. Moreover, these methods use multiple horizontally-spaced surface receivers (multi-station array), thus, lateral variability beneath the array is accounted for in their results. Most noninvasive methods, however, indirectly measure Vs, and thus have inherent uncertainties. We have used a suite of noninvasive methods at ten stations in southern California. We record microseisms using standalone single-stations, located at the end- and mid-points of the measurement array, and over the same period, we also collect records from the seismic station. Using both single- and seismic-station records, we calculate the horizontal-to-vertical-spectra-ratios (HVSR), resonance frequency, and power spectral density to study site characteristics, including noise levels. For soil sites, we generally find insignificant lateral variability in subsurface conditions beneath our multi-station arrays by matching similar spectral peaks and frequencies in the three HVSR records; for rock sites, the magnitudes of the HVSR values are not as discernible. While we find general agreement in Vs30 computed using a variety of methods at each site, preliminary results for low-noise sites using standalone passive methods have large uncertainty in their computed Vs30 values.

  12. Site characterization progress report: Yucca Mountain, Nevada. Progress report number 17, April 1, 1997--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The US Department of Energy`s (DOE) Office of Civilian Radioactive Waste Management (OCRWM), created with the enactment of the Nuclear Waste Policy Act of 1982 (NWPA), is tasked to accept and dispose of the nation`s high-level radioactive waste and spent nuclear fuel in a deep geologic repository (high-level radioactive waste program). The report summarizes significant site characterization activities during the period from April 1, 1997 through September 30, 1997, in the evaluation of Yucca Mountain as a potential site for the geologic disposal of spent nuclear fuel and high-level radioactive wastes. The progress report also cites technical reports and research products that provide the detailed information on these activities. Chapter 2 outlines technical and regulatory issues that must be addressed by the Project and planned work toward achieving future objectives concerning the viability assessment, the environmental impact statement, the site recommendation, and the license application. Chapter 3 describes technical progress in preclosure radiological safety analysis, postclosure performance assessment, and performance confirmation activities. Chapter 4 describes various aspects of repository and waste package design and construction. It also discusses the Exploration Studies Facility cross drift. Chapter 5 describes site characterization activities, and Chapter 6 contains a complete list of references.

  13. Social Networking Web Sites as a Tool for Student Transitions: Purposive Use of Social Networking Web Sites for the First-Year Experience

    Science.gov (United States)

    Nalbone, David P.; Kovach, Ronald J.; Fish, Jessica N.; McCoy, Kelsey M.; Jones, Kathryn E.; Wright, Hillary Rawlings

    2016-01-01

    The current study investigated the potential role that social networking Web sites (e.g., Facebook) played in creating both actual and virtual learning communities within the first-year seminar. Researchers conducted a 2-year longitudinal study to assess whether students who were connected within a university-founded virtual network persisted in…

  14. The Current Status of Germplum Database: a Tool for Characterization of Plum Genetic Resources in Romania

    Directory of Open Access Journals (Sweden)

    Monica Harta

    2016-11-01

    Full Text Available In Romania, Prunus genetic resources are kept in collections of varieties, populations and biotypes, mainly located in research and development institutes or fruit growing stations and, in the last years, by some private enterprises. Creating the experimental model for the Germplum database based on phenotypic descriptors and SSR molecular markers analysis is an important and topical objective for the efficient characterization of genetic resources and also for establishing a public-private partnership for the effective management of plum germplasm resources in Romania. The technical development of the Germplum database was completed and data will be added continuously after characterizing each new accession.

  15. Characterization and provenance of the building stones from Pompeii's archaeological site (southern Italy)

    Science.gov (United States)

    Balassone, G.; Kastenmeier, P.; di Maio, G.; Mormone, A.; Joachimski, M.

    2009-04-01

    Pompeii is one of the most famous and complex areas of archaeological investigation in the world and with a uniquely favorable state of preservation. Even if many studies have been devoted in time to many archaeological aspects of this ancient city, large-scale and detailed studies aimed at characterizing mineralogy, petrography and isotope geochemistry of the building stones are still lacking. The scope of the present research is to fill this gap, pointing to the definition of the provenance of the stony materials used for ancient constructions of the city of Pompeii and to the possible trade routes. This work is part of a large-scale survey carried out by the Deutsches Archäologisches Institut of Berlin, with the purposes of reconstructing the sources of raw materials of various archaeological sites of the Sarno Plain (e.g. Longola-Poggiomarino settlement, Nuceria, Stabiae, etc.) and consequently also the paleo-environments of this area during the Olocene (Seiler, 2006, 2008; Kastemeier and Seiler, 2007). We sampled all the litotypes with different macroscopic characteristics from various buildings according to location, age (time span VI century B.C. - I century A.D.) and utilization; the architectural buildings considered for this study are mainly represented public and religious buildings, houses and funerary monuments. As possible source areas, representative litotypes have been sampled from ancient pits and outcrops surrounding Pompeii as well. A set of 80 samples have been sampled by means of micro-drillings for mineralogical, petrographic and geochemical analyses, comprising optical microscopy, X-ray diffraction, inductively coupled plasma mass, X-ray fluorescence and C-O isotope geochemistry. Minero-petrographic and XRD studies of Pompeii rock samples have shown that at least ten different litologies occur as building stones, belonging to basaltic to tephritic lavas, pyroclasts (tuffs, scoriae, etc.) and sedimentary rocks (limestone, travertines

  16. 18F-FDG PET/CT as a diagnostic tool in patients with extracervical carcinoma of unknown primary site: a literature review

    DEFF Research Database (Denmark)

    Moller, Anne Kirstine Hundahl; Jakobsen, Annika Loft; Berthelsen, Anne Kiil

    2011-01-01

    Carcinoma of unknown primary (CUP) represents a heterogeneous group of metastatic malignancies for which no primary tumor site can be identified after extensive diagnostic workup. Failure to identify the primary site may negatively influence patient management. The aim of this review was to evalu......Carcinoma of unknown primary (CUP) represents a heterogeneous group of metastatic malignancies for which no primary tumor site can be identified after extensive diagnostic workup. Failure to identify the primary site may negatively influence patient management. The aim of this review...... was to evaluate (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) as a diagnostic tool in patients with extracervical CUP....

  17. Functional characterization of the major and minor phosphorylation sites of the P protein of Borna disease virus.

    Science.gov (United States)

    Schmid, Sonja; Mayer, Daniel; Schneider, Urs; Schwemmle, Martin

    2007-06-01

    The phosphoprotein P of Borna disease virus (BDV) is an essential cofactor of the viral RNA-dependent RNA polymerase. It is preferentially phosphorylated at serine residues 26 and 28 by protein kinase C epsilon (PKCepsilon) and, to a lesser extent, at serine residues 70 and 86 by casein kinase II (CKII). To determine whether P phosphorylation is required for viral polymerase activity, we generated P mutants lacking either the PKCepsilon or the CKII phosphate acceptor sites by replacing the corresponding serine residues with alanine (A). Alternatively, these sites were replaced by aspartic acid (D) to mimic phosphorylation. Functional characterization of the various mutants in the BDV minireplicon assay revealed that D substitutions at the CKII sites inhibited the polymerase-supporting activity of P, while A substitutions maintained wild-type activity. Likewise, D substitutions at the PKC sites did not impair the cofactor function of BDV-P, whereas A substitutions at these sites led to increased activity. Interestingly, recombinant viruses could be rescued only when P mutants with modified PKCepsilon sites were used but not when both CKII sites were altered. PKCepsilon mutant viruses showed a reduced capacity to spread in cell culture, while viral RNA and protein expression levels in persistently infected cells were almost normal. Further mutational analyses revealed that substitutions at individual CKII sites were, with the exception of a substitution of A for S86, detrimental for viral rescue. These data demonstrate that, in contrast to other viral P proteins, the cofactor activity of BDV-P is negatively regulated by phosphorylation.

  18. Functional Characterization of the Major and Minor Phosphorylation Sites of the P Protein of Borna Disease Virus▿

    Science.gov (United States)

    Schmid, Sonja; Mayer, Daniel; Schneider, Urs; Schwemmle, Martin

    2007-01-01

    The phosphoprotein P of Borna disease virus (BDV) is an essential cofactor of the viral RNA-dependent RNA polymerase. It is preferentially phosphorylated at serine residues 26 and 28 by protein kinase C ɛ (PKCɛ) and, to a lesser extent, at serine residues 70 and 86 by casein kinase II (CKII). To determine whether P phosphorylation is required for viral polymerase activity, we generated P mutants lacking either the PKCɛ or the CKII phosphate acceptor sites by replacing the corresponding serine residues with alanine (A). Alternatively, these sites were replaced by aspartic acid (D) to mimic phosphorylation. Functional characterization of the various mutants in the BDV minireplicon assay revealed that D substitutions at the CKII sites inhibited the polymerase-supporting activity of P, while A substitutions maintained wild-type activity. Likewise, D substitutions at the PKC sites did not impair the cofactor function of BDV-P, whereas A substitutions at these sites led to increased activity. Interestingly, recombinant viruses could be rescued only when P mutants with modified PKCɛ sites were used but not when both CKII sites were altered. PKCɛ mutant viruses showed a reduced capacity to spread in cell culture, while viral RNA and protein expression levels in persistently infected cells were almost normal. Further mutational analyses revealed that substitutions at individual CKII sites were, with the exception of a substitution of A for S86, detrimental for viral rescue. These data demonstrate that, in contrast to other viral P proteins, the cofactor activity of BDV-P is negatively regulated by phosphorylation. PMID:17376920

  19. MDC-Analyzer: a novel degenerate primer design tool for the construction of intelligent mutagenesis libraries with contiguous sites

    National Research Council Canada - National Science Library

    Tang, Lixia; Wang, Xiong; Ru, Beibei; Sun, Hengfei; Huang, Jian; Gao, Hui

    2014-01-01

    ...) for the automated design of intelligent mutagenesis libraries that can completely cover user-defined randomized sequences, especially when multiple contiguous and/or adjacent sites are targeted...

  20. Prospective Molecular Characterization of Burn Wound Colonization: Novel Tools and Analysis

    Science.gov (United States)

    2012-10-01

    and validated culture-independent molecular tools for quantifying and identifying wound fungi . We also initiated a prospective study to elucidate the...Quantitative polymerase chain reaction (qPCR); Fungi ; Bacteria 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a...1) Isolate and purify total DNA, RNA, and Protein from each sample 2) Analyze the microbial community composition by sequencing analysis a. 16S

  1. EXAFS as a tool for catalyst characterization: a review of the data analysis methods

    OpenAIRE

    Noronha,F.B.

    1999-01-01

    A review of the EXAFS data analysis methods is presented. A detailed description of the EXAFS signal extraction and the Fourier transform of the data are discussed. The procedure for determining interatomic distances, coordination numbers and disorder effects from EXAFS data is described. This paper also discusses the data analysis statistics. Finally, one example of catalyst characterization by the EXAFS technique is reported.

  2. Assessing landslide potential on coastal bluffs near Mukilteo, Washington—Geologic site characterization for hydrologic monitoring

    Science.gov (United States)

    Mirus, Benjamin B.; Smith, Joel B.; Benjamin Stark,; York Lewis,; Abigail Michel,; Baum, Rex L.

    2016-07-01

    During the summer 2015, the U.S. Geological Survey collected geologic and geotechnical data for two sites on coastal bluffs along the eastern shore of Puget Sound, Washington. The U.S. Geological Survey also installed hydrologic instrumentation at the sites and collected specimens for laboratory testing. The two sites are located on City of Mukilteo open-space land and are about 0.6 kilometers apart. The bluffs at each site are approximately 42 meters high, and rise steeply from the shoreline with 32–35° slopes. The more northerly of the two sites occupies an active landslide and is mostly unvegetated. The other site is forested, and although stable during the preparation of this report, shows evidence of historical and potential landslide activity. The slopes of the bluffs at both sites are mantled by a thin, nonuniform colluvium underlain by clay-rich glacial deposits and tills of the Whidbey Formation or Double Bluff Drift. Till consisting of sand, gravel, and cobbles caps the bluffs and rests on finer grained glacial deposits of sand, silt, and clay. These types of different glacial deposits are dense, vertically fractured, and generally have low permeability, but field observations indicate that locally the deposits are sufficiently permeable to allow lateral flow of water along fractures and subhorizontal boundaries between deposits of different texture. Laboratory tests indicate that many of the deposits are highly plastic, with low hydraulic conductivity, and moderate shear strength. Steep slopes combined with the strength and hydraulic characteristics of the deposits leave the bluffs prone to slope instability, particularly during the wet season when infiltrating rainfall changes moisture content, pore-water pressure, and effective stress within the hillslope. The instrumentation was designed to primarily observe rainfall variability and hydrologic changes in the subsurface that can affect stability of the bluffs, and also to compare the hydrologic

  3. MAP_CHANNELS: a computation tool to aid in the visualization and characterization of solvent channels in macromolecular crystals.

    Science.gov (United States)

    Juers, Douglas H; Ruffin, Jon

    2014-12-01

    A computation tool is described that facilitates visualization and characterization of solvent channels or pores within macromolecular crystals. A scalar field mapping the shortest distance to protein surfaces is calculated on a grid covering the unit cell and is written as a map file. The map provides a multiscale representation of the solvent channels, which when viewed in standard macromolecular crystallographic software packages gives an intuitive sense of the solvent channel architecture. The map is analysed to yield descriptors of the topology and the morp