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Sample records for sisnensis obs sobre

  1. Find an Ob-Gyn

    Science.gov (United States)

    ... Management Education & Events Advocacy For Patients About ACOG Find an Ob-Gyn Home About ACOG Find an Ob-Gyn Page Navigation ▼ About Us ACOG ... Districts ACOG Sections Careers at ACOG Contact Us Find an Ob-Gyn Search by State Search by ...

  2. Glucose metabolism and recycling by hepatocytes of OB/OB and ob/ob mice

    International Nuclear Information System (INIS)

    Lahtela, J.T.; Wals, P.A.; Katz, J.

    1990-01-01

    Hepatocytes were prepared from livers of ob/ob (obese diabetic) mice and their lean (OB/OB) siblings that had been fasted for 24 h. The hepatocytes were incubated with [U-14C, 2-3H]-, [U-14C, 3-3H]-, and [U-14C, 6-3H]glucose at concentrations from 20 to 120 mM. 14C was recovered mainly in CO2, glycogen, and lactate. Tritium was recovered in water and glycogen. The yield in labeled products from [2-3H]glucose ranged from two to three times that from [U-14C]glucose. The yields from [3-3H]- and [6-3H]glucose were similar, and 1.3-1.7 times that from [U-14C]glucose. At 40 mM, total utilization of glucose by obese mice was about twice that for lean mice, but there was little difference at 120 mM. The rate of recycling between glucose and glucose 6-phosphate was calculated. An equation to calculate the rate of recycling of glucose from the 2-3H/U-14C ratio in glycogen is derived in the APPENDIX. Our results show that (1) the utilization of glucose by hepatocytes from obese diabetic mice exceeds that of their lean controls, (2) the rate of glucose phosphorylation in both groups greatly exceeds glucose uptake and the rate of glycogen synthesis, (3) glucose phosphorylation represents a difference between a high glucokinase rate and hydrolysis of glucose 6-phosphate, and (4) recycling of glucose carbon between glucose 6-phosphate and pyruvate occurs within mouse hepatocytes

  3. Peripheral nervous system insulin resistance in ob/ob mice

    Science.gov (United States)

    2013-01-01

    Background A reduction in peripheral nervous system (PNS) insulin signaling is a proposed mechanism that may contribute to sensory neuron dysfunction and diabetic neuropathy. Neuronal insulin resistance is associated with several neurological disorders and recent evidence has indicated that dorsal root ganglion (DRG) neurons in primary culture display altered insulin signaling, yet in vivo results are lacking. Here, experiments were performed to test the hypothesis that the PNS of insulin-resistant mice displays altered insulin signal transduction in vivo. For these studies, nondiabetic control and type 2 diabetic ob/ob mice were challenged with an intrathecal injection of insulin or insulin-like growth factor 1 (IGF-1) and downstream signaling was evaluated in the DRG and sciatic nerve using Western blot analysis. Results The results indicate that insulin signaling abnormalities documented in other “insulin sensitive” tissues (i.e. muscle, fat, liver) of ob/ob mice are also present in the PNS. A robust increase in Akt activation was observed with insulin and IGF-1 stimulation in nondiabetic mice in both the sciatic nerve and DRG; however this response was blunted in both tissues from ob/ob mice. The results also suggest that upregulated JNK activation and reduced insulin receptor expression could be contributory mechanisms of PNS insulin resistance within sensory neurons. Conclusions These findings contribute to the growing body of evidence that alterations in insulin signaling occur in the PNS and may be a key factor in the pathogenesis of diabetic neuropathy. PMID:24252636

  4. Genetically obese (ob/ob) mice are resistant to the lethal effects of thioacetamide hepatotoxicity

    International Nuclear Information System (INIS)

    Won, Young-Suk; Song, Ji-Won; Lim, Jong-Hwan; Lee, Mee-Young; Moon, Og-Sung; Kim, Hyoung-Chin; Son, Hwa-Young; Kwon, Hyo-Jung

    2016-01-01

    Obesity increases the risk of chronic liver diseases, including viral hepatitis, alcohol-induced liver disease, and non-alcoholic steatohepatitis. In this study, we investigated the effects of obesity in acute hepatic failure using a murine model of thioacetamide (TA)-induced liver injury. Genetically obese ob/ob mice, together with non-obese ob/+ littermates, were subjected to a single intraperitoneal injection of TA, and examined for signs of hepatic injury. ob/ob mice showed a significantly higher survival rate, lower levels of serum alanine aminotransferase and aspartate aminotransferase, and less hepatic necrosis and apoptosis, compared with ob/+ mice. In addition, ob/ob mice exhibited significantly lower levels of malondialdehyde and significantly higher levels of glutathione and antioxidant enzyme activities compared with their ob/+ counterparts. Bioactivation analyses revealed reduced plasma clearance of TA and covalent binding of [ 14 C]TA to liver macromolecules in ob/ob mice. Together, these data demonstrate that genetically obese mice are resistant to TA-induced acute liver injury through diminished bioactivation of TA and antioxidant effects. - Highlights: • ob/ob mice are resistant to lethal doses of thioacetamide, compared to ob/+ mice. • ob/ob mice show reduced oxidative stress and enhanced antioxidant enzyme activity. • ob/ob mice exhibit diminished bioactivation of thioacetamide.

  5. Genetically obese (ob/ob) mice are resistant to the lethal effects of thioacetamide hepatotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Won, Young-Suk [Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk (Korea, Republic of); Song, Ji-Won [Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon (Korea, Republic of); Lim, Jong-Hwan [Huons Research Center, Gyonggido (Korea, Republic of); Lee, Mee-Young [Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of); Moon, Og-Sung; Kim, Hyoung-Chin [Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk (Korea, Republic of); Son, Hwa-Young [Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon (Korea, Republic of); Kwon, Hyo-Jung, E-mail: hyojung@cnu.ac.kr [Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon (Korea, Republic of)

    2016-01-15

    Obesity increases the risk of chronic liver diseases, including viral hepatitis, alcohol-induced liver disease, and non-alcoholic steatohepatitis. In this study, we investigated the effects of obesity in acute hepatic failure using a murine model of thioacetamide (TA)-induced liver injury. Genetically obese ob/ob mice, together with non-obese ob/+ littermates, were subjected to a single intraperitoneal injection of TA, and examined for signs of hepatic injury. ob/ob mice showed a significantly higher survival rate, lower levels of serum alanine aminotransferase and aspartate aminotransferase, and less hepatic necrosis and apoptosis, compared with ob/+ mice. In addition, ob/ob mice exhibited significantly lower levels of malondialdehyde and significantly higher levels of glutathione and antioxidant enzyme activities compared with their ob/+ counterparts. Bioactivation analyses revealed reduced plasma clearance of TA and covalent binding of [{sup 14}C]TA to liver macromolecules in ob/ob mice. Together, these data demonstrate that genetically obese mice are resistant to TA-induced acute liver injury through diminished bioactivation of TA and antioxidant effects. - Highlights: • ob/ob mice are resistant to lethal doses of thioacetamide, compared to ob/+ mice. • ob/ob mice show reduced oxidative stress and enhanced antioxidant enzyme activity. • ob/ob mice exhibit diminished bioactivation of thioacetamide.

  6. Zinc metabolism in genetically obese (ob/ob) mice

    International Nuclear Information System (INIS)

    Kennedy, M.L.; Failla, M.L.

    1987-01-01

    Recent reports indicate that the concentrations and total amounts of several essential trace metals in various tissues of genetically obese rodents differ markedly from those in lean controls. In the present studies the absorption, retention and tissue distribution of zinc and constitutive levels of zinc-metallothionein (Zn-MT) in selected tissues were compared in obese (ob/ob) and lean (+/?) C57BL/6J mice. When 5-, 10- and 22-wk-old mice were administered 1.2 mumol 65 Zn by stomach tube the apparent absorption of 65 Zn by obese mice was 1.5, 2.2 and 3.9 times higher, respectively, than that in age-matched lean mice. Retention of orally administered 65 Zn after 96 h was also substantially higher in obese mice than in lean mice. To assess the possible influences of hyperphagia and intestinal hypertrophy on the enhanced apparent absorption of 65 Zn by obese mice food intake by an additional group of obese mice was restricted to that of age-matched lean controls. When actual absorption of zinc was determined according to the method of Heth and Hoekstra, groups of ad libitum--fed obese, pair-fed obese and lean mice absorbed 38, 32 and 18% of administered 65 Zn, respectively. In contrast, the rate of 65 Zn excretion 2-6 d after oral or subcutaneous administration of the metal was similar for obese and lean mice. Unrestricted and pair-fed obese mice had significantly lower percentages of carcass 65 Zn present in skin, muscle plus bone, spleen and testes and higher percentages present in liver, small intestine and adipose tissue than lean mice

  7. Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

    Science.gov (United States)

    Sartori, Michelle; Conti, Filipe F.; Dias, Danielle da Silva; dos Santos, Fernando; Machi, Jacqueline F.; Palomino, Zaira; Casarini, Dulce E.; Rodrigues, Bruno; De Angelis, Kátia; Irigoyen, Maria-Claudia

    2017-01-01

    Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stress markers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF) and AP were similar between groups; however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index. Moreover, the OB group exhibited important autonomic dysfunction and baroreflex sensitivity impairment, when compared to WT group. OB group showed increased Angiotensin II levels in heart and renal tissues; decreased adiponectin and increased inflammatory markers in adipose tissue and spleen. Additionally, OB mice presented a higher damage to proteins and lipoperoxidation and lower activity of antioxidant enzymes in kidney and heart. Correlations were found between autonomic dysfunction with angiotensin II and inflammatory mediators, as well as between inflammation and oxidative stress. Conclusions: Our results showed that female adult ob/ob mice presented discrete diastolic dysfunction accompanied by autonomic disorder, which is associated with inflammation and oxidative stress in these animals. PMID:28878683

  8. Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

    Directory of Open Access Journals (Sweden)

    Michelle Sartori

    2017-08-01

    Full Text Available Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice.Methods: Metabolic parameters, cardiac function, arterial pressure (AP, autonomic, hormonal, inflammatory, and oxidative stress markers were evaluated in 12-weeks female wild-type (WT group and ob/ob mice (OB group.Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF and AP were similar between groups; however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index. Moreover, the OB group exhibited important autonomic dysfunction and baroreflex sensitivity impairment, when compared to WT group. OB group showed increased Angiotensin II levels in heart and renal tissues; decreased adiponectin and increased inflammatory markers in adipose tissue and spleen. Additionally, OB mice presented a higher damage to proteins and lipoperoxidation and lower activity of antioxidant enzymes in kidney and heart. Correlations were found between autonomic dysfunction with angiotensin II and inflammatory mediators, as well as between inflammation and oxidative stress.Conclusions: Our results showed that female adult ob/ob mice presented discrete diastolic dysfunction accompanied by autonomic disorder, which is associated with inflammation and oxidative stress in these animals.

  9. 2MASS Identifications for Galactic OB Stars

    OpenAIRE

    Reed, B. Cameron

    2007-01-01

    Cross-identifications for 14,574 intrinsically luminous galactic stars (mostly OB stars) to objects in the 2MASS survey have been determined using a search box of +/-0.0015 degrees (+/- 5.4 arcsec) in both RA and Dec. Instructions on obtaining the relevant files can be obtained at othello.alma.edu/~reed/OB-2MASS.doc.

  10. Structural anatomy of telomere OB proteins.

    Science.gov (United States)

    Horvath, Martin P

    2011-10-01

    Telomere DNA-binding proteins protect the ends of chromosomes in eukaryotes. A subset of these proteins are constructed with one or more OB folds and bind with G+T-rich single-stranded DNA found at the extreme termini. The resulting DNA-OB protein complex interacts with other telomere components to coordinate critical telomere functions of DNA protection and DNA synthesis. While the first crystal and NMR structures readily explained protection of telomere ends, the picture of how single-stranded DNA becomes available to serve as primer and template for synthesis of new telomere DNA is only recently coming into focus. New structures of telomere OB fold proteins alongside insights from genetic and biochemical experiments have made significant contributions towards understanding how protein-binding OB proteins collaborate with DNA-binding OB proteins to recruit telomerase and DNA polymerase for telomere homeostasis. This review surveys telomere OB protein structures alongside highly comparable structures derived from replication protein A (RPA) components, with the goal of providing a molecular context for understanding telomere OB protein evolution and mechanism of action in protection and synthesis of telomere DNA.

  11. Hydrogen sulfide improves diabetic wound healing in ob/ob mice via attenuating inflammation.

    Science.gov (United States)

    Zhao, Huichen; Lu, Shengxia; Chai, Jiachao; Zhang, Yuchao; Ma, Xiaoli; Chen, Jicui; Guan, Qingbo; Wan, Meiyan; Liu, Yuantao

    2017-09-01

    The proposed mechanisms of impaired wound healing in diabetes involve sustained inflammation, excess oxidative stress and compromised agiogenesis. Hydrogen sulfide (H 2 S) has been reported to have multiple biological activities. We aim to investigate the role of H 2 S in impaired wound healing in ob/ob mice and explore the possible mechanisms involved. Full-thickness skin dorsal wounds were created on ob/ob mice and C57BL/6 mice. Cystathionine-γ-lyase (CSE) expression and H 2 S production were determined in granulation tissues of the wounds. Effects of NaHS on wound healing were evaluated. Inflammation and angiogenesis in granulation tissues of the wounds were examined. CSE expression, and H 2 S content were significantly reduced in granulation tissues of wounds in ob/ob mice compared with control mice. NaHS treatment significantly improved wound healing in ob/ob mice, which was associated with reduced neutrophil and macrophage infiltration, decreased production of tumor necrosis factor (TNF)-α, interleukin (IL)-6. NaHS treatment decreased metalloproteinase (MMP)-9, whereas increased collagen deposition and vascular-like structures in granulation tissues of wounds in ob/ob mice. CSE down-regulation may play a role in the pathogenesis of diabetic impaired wound healing. Exogenous H 2 S could be a potential agent to improve diabetic impaired wound healing by attenuating inflammation and increasing angiogenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Impaired Muscle Regeneration in Ob/ob and Db/db Mice

    Directory of Open Access Journals (Sweden)

    Mai-Huong Nguyen

    2011-01-01

    Full Text Available In obesity and type 2 diabetes, efficient skeletal muscle repair following injury may be required, not only for restoring muscle structure and function, but also for maintaining exercise capacity and insulin sensitivity. The hypothesis of this study was that muscle regeneration would be impaired in ob/ob and db/db mice, which are common mouse models of obesity and type 2 diabetes. Muscle injury was produced by cardiotoxin injection, and regeneration was assessed by morphological and immunostaining techniques. Muscle regeneration was delayed in ob/ob and db/db mice, but not in a less severe model of insulin resistance – feeding a high-fat diet to wild-type mice. Angiogenesis, cell proliferation, and myoblast accumulation were also impaired in ob/ob and db/db mice, but not the high-fat diet mice. The impairments in muscle regeneration were associated with impaired macrophage accumulation; macrophages have been shown previously to be required for efficient muscle regeneration. Impaired regeneration in ob/ob and db/db mice could be due partly to the lack of leptin signaling, since leptin is expressed both in damaged muscle and in cultured muscle cells. In summary, impaired muscle regeneration in ob/ob and db/db mice was associated with reduced macrophage accumulation, angiogenesis, and myoblast activity, and could have implications for insulin sensitivity in the skeletal muscle of obese and type 2 diabetic patients.

  13. HSL Attenuates the Follicular Oxidative Stress and Enhances the Hair Growth in ob/ob Mice

    Directory of Open Access Journals (Sweden)

    Takeo Minematsu, PhD

    2013-10-01

    Full Text Available Summary: We demonstrated enhanced hair regeneration following topical administration of N-(3-oxododecanoyl-L-homoserine lactone (HSL in ob/ob mice. The ob/ob mice showed delayed hair regeneration (more than 6 wk after depilation, which rapidly induced transition to anagen in the hair cycle in wild-type mice. Vehicle and HSL solutions were applied to the depilated dorsal skin of ob/ob mice. The depilated skin of the HSL-treated mice was fully covered with hair, whereas no macroscopic alteration was observed in vehicle-treated group by the fourth week after depilation. Oxidative stress was drastically decreased and the expression of the antioxidative enzymes PON1 and PON3 was increased in the HSL-treated skin with highly proliferative anagen follicles. These results suggest that HSL is a candidate therapeutic agent for alopecia in metabolic syndrome.

  14. Serotonin transporter (SERT and translocator protein (TSPO expression in the obese ob/ob mouse

    Directory of Open Access Journals (Sweden)

    Santini Ferruccio

    2011-02-01

    Full Text Available Abstract Background An ever growing body of evidences is emerging concerning metabolism hormones, neurotransmitters or stress-related biomarkers as effective modulators of eating behavior and body weight in mammals. The present study sought at examining the density and affinity of two proteins related to neurotransmission and cell metabolism, the serotonin transporter SERT and the cholesterol import-benzodiazepine site TSPO (translocator protein, in a rodent leptin-lacking mutant, the obese ob/ob mouse. Binding studies were thus carried out in brain or peripheral tissues, blood platelets (SERT and kidneys (TSPO, of ob/ob and WT mice supplied with a standard diet, using the selective radiochemical ligands [3H]-paroxetine and [3H]-PK11195. Results We observed comparable SERT number or affinity in brain and platelets of ob/ob and WT mice, whilst a significantly higher [3H]-PK11195 density was reported in the brain of ob/ob animals. TSPO binding parameters were similar in the kidneys of all tested mice. By [3H]-PK11195 autoradiography of coronal hypothalamic-hippocampal sections, an increased TSPO signal was detected in the dentate gyrus (hippocampus and choroids plexus of ob/ob mice, without appreciable changes in the cortex or hypothalamic-thalamic regions. Conclusions These findings show that TSPO expression is up-regulated in cerebral regions of ob/ob leptin-deficient mice, suggesting a role of the translocator protein in leptin-dependent CNS trophism and metabolism. Unchanged SERT in mutant mice is discussed herein in the context of previous literature as the forerunner to a deeper biochemical investigation.

  15. Ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia.

    Directory of Open Access Journals (Sweden)

    Michael J J Chu

    Full Text Available BACKGROUND: Hepatic steatosis is a major risk factor for graft failure in liver transplantation. Hepatic steatosis shows a greater negative influence on graft function following prolonged cold ischaemia. As the impact of steatosis on hepatocyte metabolism during extended cold ischaemia is not well-described, we compared markers of metabolic capacity and mitochondrial function in steatotic and lean livers following clinically relevant durations of cold preservation. METHODS: Livers from 10-week old leptin-deficient obese (ob/ob, n = 9 and lean C57 mice (n = 9 were preserved in ice-cold University of Wisconsin solution. Liver mitochondrial function was then assessed using high resolution respirometry after 1.5, 3, 5, 8, 12, 16 and 24 hours of storage. Metabolic marker enzymes for anaerobiosis and mitochondrial mass were also measured in conjunction with non-bicarbonate tissue pH buffering capacity. RESULTS: Ob/ob and lean mice livers showed severe (>60% macrovesicular and mild (<30% microvesicular steatosis on Oil Red O staining, respectively. Ob/ob livers had lower baseline enzymatic complex I activity but similar adenosine triphosphate (ATP levels compared to lean livers. During cold storage, the respiratory control ratio and complex I-fueled phosphorylation deteriorated approximately twice as fast in ob/ob livers compared to lean livers. Ob/ob livers also demonstrated decreased ATP production capacities at all time-points analyzed compared to lean livers. Ob/ob liver baseline lactate dehydrogenase activities and intrinsic non-bicarbonate buffering capacities were depressed by 60% and 40%, respectively compared to lean livers. CONCLUSIONS: Steatotic livers have impaired baseline aerobic and anaerobic capacities compared to lean livers, and mitochondrial function indices decrease particularly from after 5 hours of cold preservation. These data provide a mechanistic basis for the clinical recommendation of shorter cold storage durations in

  16. Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice

    Science.gov (United States)

    The orexigenic hormone ghrelin is important in diabetes because it has an inhibitory effect on insulin secretion. Ghrelin ablation in leptin-deficient ob/ob (Ghrelin(-/-):ob/ob) mice increases insulin secretion and improves hyperglycemia. The physiologically relevant ghrelin receptor is the growth ...

  17. Leptin differentially regulates STAT3 activation in the ob/ob mice adipose mesenchymal stem cells

    Science.gov (United States)

    Leptin-deficient genetically obese ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Studies have shown that multipotent stem cells isolated from adult adipose tissue can differentiate into adipocytes ex vivo and thereby contribute...

  18. Leptin differentially regulate STAT3 activation in ob/ob mouse adipose mesenchymal stem cells

    Directory of Open Access Journals (Sweden)

    Zhou Zhou

    2012-12-01

    Full Text Available Abstract Background Leptin-deficient ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Multipotent stem cells isolated from adult adipose tissue can differentiate into adipocytes ex vivo and thereby contribute toward increased adipocyte cell numbers, obesity, and inflamm ation. Currently, information is lacking regarding regulation of adipose stem cell numbers as well as leptin-induced inflammation and its signaling pathway in ob/ob mice. Methods Using leptin deficient ob/ob mice, we investigated whether leptin injection into ob/ob mice increases adipose stem cell numbers and adipose tissue inflammatory marker MCP-1 mRNA and secretion levels. We also determined leptin mediated signaling pathways in the adipose stem cells. Results We report here that adipose stem cell number is significantly increased following leptin injection in ob/ob mice and with treatment of isolated stem cells with leptin in vitro. Leptin also up-regulated MCP-1 secretion in a dose- and time-dependent manner. We further showed that increased MCP-1 mRNA levels were due to increased phosphorylation of Signal Transducer and Activator of Transcription 3 (STAT3 Ser727 but not STAT3 Tyr705 phosphorylation, suggesting differential regulation of MCP-1 gene expression under basal and leptin-stimulated conditions in adipose stem cells. Conclusions Taken together, these studies demonstrate that leptin increases adipose stem cell number and differentially activates STAT3 protein resulting in up-regulation of MCP-1 gene expression. Further studies of mechanisms mediating adipose stem cell hyperplasia and leptin signaling in obesity are warranted and may help identify novel anti-obesity target strategies.

  19. iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice.

    Science.gov (United States)

    Sasaki, Mari; Shinozaki, Shohei; Morinaga, Hironobu; Kaneki, Masao; Nishimura, Emi; Shimokado, Kentaro

    2018-07-02

    Previous studies have shown that androgenic alopecia is associated with metabolic syndrome and diabetes. However, the detailed mechanism whereby diabetes causes alopecia still remains unclear. We focused on the inflammatory response that is caused by diabetes or obesity, given that inflammation is a risk factor for hair loss. Inducible nitric oxide synthase (iNOS) is known to be upregulated under conditions of acute or chronic inflammation. To clarify the potential role of iNOS in diabetes-related alopecia, we generated obese diabetic iNOS-deficient (ob/ob; iNOS-KO mice). We observed that ob/ob; iNOS-KO mice were potentiated for the transition from telogen (rest phase) to anagen (growth phase) in the hair cycle compared with iNOS-proficient ob/ob mice. To determine the effect of nitric oxide (NO) on the hair cycle, we administered an iNOS inhibitor intraperitoneally (compound 1400 W, 10 mg/kg) or topically (10% aminoguanidine) in ob/ob mice. We observed that iNOS inhibitors promoted anagen transition in ob/ob mice. Next, we administered an NO donor (S-nitrosoglutathione, GSNO), to test whether NO has the telogen elongation effects. The NO donor was sufficient to induce telogen elongation in wild-type mice. Together, our data indicate that iNOS-derived NO plays a role in telogen elongation under the inflammatory conditions associated with diabetes in mice. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  20. Sequential formation of subgroups in OB associations

    International Nuclear Information System (INIS)

    Elmegreen, B.G.; Lada, C.J.

    1977-01-01

    We reconsider the structure and formation of OB association in view of recent radio and infrared observations of the adjacent molecular clouds. As a result of this reexamination, we propose that OB subgroups are formed in a step-by-step process which involves the propagation of ionization (I) and shock (S) fronts through a molecular cloud complex. OB stars formed at the edge of a molecular cloud drive these I-S fronts into the cloud. A layer of dense neutral material accumulates between the I and S fronts and eventually becomes gravitationally unstable. This process is analyzed in detail. Several arguments concerning the temperature and mass of this layer suggest that a new OB subgroup will form. After approximately one-half million years, these stars will emerge from and disrupt the star-forming layer. A new shock will be driven into the remaining molecular cloud and will initiate another cycle of star formation.Several observed properties of OB associations are shown to follow from a sequential star-forming mechanism. These include the spatial separation and systematic differences in age of OB subgroups in a given association, the regularity of subgroup masses, the alignment of subgroups along the galactic plane, and their physical expansion. Detailed observations of ionization fronts, masers, IR sources, and molecular clouds are also in agreement with this model. Finally, this mechanism provides a means of dissipating a molecular cloud and exposing less massive stars (e.g., T Tauri stars) which may have formed ahead of the shock as part of the original cloud collapsed and fragmented

  1. Manta A New BroadBand OBS

    Science.gov (United States)

    Hello, Y.; Yegikyan, M.; Charvis, P.; Philippe, O.

    2017-12-01

    Manta is a new BroadBand OBS developed at Geoazur and commercialized by Osean. The design is inspired by 3-years autonomy MUG-OBS a Multiparameter Ocean Bottom System which carry a lot of sort of sensor types. As Mug-OBS, Manta-OBS rated 6000m is designed to resist a trawling. All the components are non corrosive such polyethylene, titanium and buoyancy is ensured by syntactic foam. Equipped in standard version with a Trillium compact OBS Manta has an autonomy of 18 months, but can accept on its 4 input channels any kind of signal as low as from an hydrophone or larger from other type of a seismometer or accelerometer. Tri-axial geophones unit (2 Hz or 4.5 Hz ) can replace the seismometer and will expend the lifespan for the instrument. The seismometer is encapsulated in a central well established by four panels of the main structure to protect it from sea current convection and is decoupled from main chassis. An health bulletin is recoverable by acoustic any time to facilitate the installation and during a visit when instrument is deployed. Main parameters for acquisition can be changed by acoustics command from surface at any time. Once at the bottom, release for the main sensor installation is programmed on a timer but controlled by the tilt of the OBS. If the tilt is too important based on programmed limits, sensor will not released automatically, but this can be forced by acoustic command after returning the tilt informations to the boat operator. Manta is equipped with flash light and AIS system for easy location at recovery, and can also send it's position by Iridium satellite in case of an unexpected ascent such caused by a possible trawling if deployed in shallow water. Clock drift calculation is automatically made against GPS time signal once the OBS return at the surface. The recovery of the OBS is initiated by an acoustic command. These new features made Manta a very versatile instrument for monitoring earthquakes.

  2. uvby and JHKL photometry of OB stars in the association Cygnus OB2

    International Nuclear Information System (INIS)

    Torres-Dodgen, A.V.; Carroll, M.; Tapia, M.

    1991-01-01

    We have obtained uvby and JHK photometry of about 80 stars in the association Cygnus OB2 (VI Cygni), including some foreground stars and three infrared sources. We present colour-colour and colour-magnitude diagrams from which we derive the interstellar extinction and approximate spectral types. We confirm that the interstellar extinction law in the direction of Cyg OB2 is similar to the galactic mean. (author)

  3. Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice.

    Science.gov (United States)

    Choi, Ha-Neul; Jang, Yang-Hee; Kim, Min-Joo; Seo, Min Jeong; Kang, Byoung Won; Jeong, Yong Kee; Kim, Jung-In

    2014-04-01

    Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined. Consumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels. These results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.

  4. Switching performance of OBS network model under prefetched real traffic

    Science.gov (United States)

    Huang, Zhenhua; Xu, Du; Lei, Wen

    2005-11-01

    Optical Burst Switching (OBS) [1] is now widely considered as an efficient switching technique in building the next generation optical Internet .So it's very important to precisely evaluate the performance of the OBS network model. The performance of the OBS network model is variable in different condition, but the most important thing is that how it works under real traffic load. In the traditional simulation models, uniform traffics are usually generated by simulation software to imitate the data source of the edge node in the OBS network model, and through which the performance of the OBS network is evaluated. Unfortunately, without being simulated by real traffic, the traditional simulation models have several problems and their results are doubtable. To deal with this problem, we present a new simulation model for analysis and performance evaluation of the OBS network, which uses prefetched IP traffic to be data source of the OBS network model. The prefetched IP traffic can be considered as real IP source of the OBS edge node and the OBS network model has the same clock rate with a real OBS system. So it's easy to conclude that this model is closer to the real OBS system than the traditional ones. The simulation results also indicate that this model is more accurate to evaluate the performance of the OBS network system and the results of this model are closer to the actual situation.

  5. Deflection routing scheme for GMPLS-based OBS networks

    DEFF Research Database (Denmark)

    Eid, Arafat; Mahmood, Waqar; Alomar, Anwar

    2010-01-01

    Integrating the Generalized Multi-Protocol Label Switching (GMPLS) framework into an Optical Burst Switching (OBS) Control Plane is a promising solution to alleviating most of OBS performance and design issues. However, implementing the already proposed OBS deflection routing schemes is not appli...

  6. Alpha-1 adrenoceptors in brown adipose tissue of lean and ob/ob mice

    International Nuclear Information System (INIS)

    Behrens-Zaror, G.; Himms-Hagen, J.

    1986-01-01

    Obese (ob/ob) mice have a low capacity to increase thyroxine 5'-deiodinase (T4 5'-D) in brown adipose tissue (BAT) when exposed to cold. This effect is mediated by alpha-1 (A-1) adrenoceptors. The authors objective was to find out whether BAT of the ob/ob mouse has normal A-1 receptors. Saturation analysis of binding of [3H]-WB4101 at 0.05 nM to 10 μM to crude membrane preparations (100,000 g pellets from Polytron homogenates) using the LIGAND program of Munson and Rodbard, showed two populations of binding sites in BAT of lean (+/+, 11-15 wk old) mice. Acute exposure (12 h, 14 0 C) or acclimation to cold (3 wk, 14 0 C) did not alter affinity or concentration of sites. Displacement with yohimbine and prazosin indicated binding of WB4101 to A-1 receptors. Very young (5 wk) lean (+/.) and obese mice had similar affinity constants (lean 0.13 +/- 0.043 and 34.2 +/- 14.9; obese, 0.12 +/- 0.028 and 20.9 +/- 5.48 nM) and concentrations (lean 22.4 +/- 3.8 and 647 +/- 137; obese, 28.6 +/- 4.6 and 547 +/- 105 fmol/mg protein) of sites. Old (1 yr) mice had high affinity sites similar to those in younger animals (KD lean 0.19 +/- 0.028, obese, 0.25 +/- 0.075; Bmax lean, 60.2 +/- 12.1; obese, 63.1 +/- 13.5 fmol/mg protein). The authors conclude that the ob/ob mouse has normal high affinity A-1 receptors in BAT. Anomalous properties of low affinity binding in old ob/ob mice could not be characterized because of high nonspecific binding. BAT of the ob/ob mouse does not lack A-1 receptors but may have a post-receptor alteration in the A-1 adrenoceptor-mediated response

  7. Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice

    OpenAIRE

    Choi, Ha-Neul; Jang, Yang-Hee; Kim, Min-Joo; Seo, Min Jeong; Kang, Byoung Won; Jeong, Yong Kee; Kim, Jung-In

    2014-01-01

    BACKGROUND/OBJECTIVES Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. MATERIALS/METHODS Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free...

  8. Automated identification of OB associations in M31

    Science.gov (United States)

    Magnier, Eugene A.; Battinelli, Paolo; Lewin, Walter H. G.; Haiman, Zoltan; Paradijs, Jan Van; Hasinger, Guenther; Pietsch, Wolfgang; Supper, Rodrigo; Truemper, Joachim

    1993-01-01

    A new identification of OB associations in M31 has been performed using the Path Linkage Criterion (PLC) technique of Battinelli (1991). We found 174 associations with a very small contamination (less than 5%) by random clumps of stars. The expected total number and average size of OB associations in the region of M 31 covered by our data set (Magnier et al. 1992) are approximately 280 and approximately 90 pc, respectively. M31 associations therefore have sizes similar to those of OB associations observed in nearby galaxies, so that we can consider them to be classical OB associations. This list of OB associations will be used for the study of the spatial distribution of OB associations and their correlation with other objects. Taking into account the fact that we do not cover the entire disk of M31, we extrapolate a total number of association in M31 of approximately 420.

  9. COMP-angiopoietin-1 recovers molecular biomarkers of neuropathy and improves vascularisation in sciatic nerve of ob/ob mice.

    Directory of Open Access Journals (Sweden)

    Joanna Kosacka

    Full Text Available BACKGROUND: Leptin-deficient ob/ob mice are a model of type 2 diabetes induced peripheral neuropathy. Ob/ob mice exhibit obesity, insulin resistance, hyperglycaemia, and alterations of peripheral nerve fibres and endoneural microvessels. Here we test the hypothesis that cartilage oligomeric matrix protein (COMP-Ang-1, a soluble and stabile form of Ang-1 which promotes angiogenesis and nerve growth, improves regeneration of nerve fibres and endoneural microvessels in ob/ob mice. METHODS AND FINDINGS: COMP-Ang-1 (100 ng/ml or NaCl were intraperitoneally (i.p. injected into male (N = 184, 3-month old, ob/ob or ob/+ mice for 7 and 21 days. We measured expression of Nf68, GAP43, Cx32, Cx26, Cx43, and TNFα in sciatic nerves using Western blot analysis. To investigate the inflammation in sciatic nerves, numbers of macrophages and T-cells were counted after immunofluorescence staining. In ultrathin section, number of myelinated/non-mylinated nerve fibers, g-ratio, the thickness of Schwann cell basal lamina and microvessel endothelium were investigated. Endoneural microvessels were reconstructed with intracardial FITC injection. Treatment with COMP-Ang-1 over 21 days significantly reduced fasting blood glucose and plasma cholesterol concentrations compared to saline treated ob/ob mice. In addition, COMP-Ang-1 treatment: 1 up-regulated expression of Nf68 and GAP43; 2 improved expression of gap junction proteins including connexin 32 and 26; 3 suppressed the expression of TNFα and Cx43 and 4 led to decreased macrophage and T-cell infiltration in sciatic nerve of ob/ob mice. The significant changes of sciatic nerve ultrastructure were not observed after 21-day long COMP-Ang-1 treatment. COMP-Ang-1 treated ob/ob mice displayed regeneration of small-diameter endoneural microvessels. Effects of COMP-Ang-1 corresponded to increased phosphorylation of Akt and p38 MAPK upon Tie-2 receptor. CONCLUSIONS: COMP-Ang-1 recovers molecular biomarkers of neuropathy

  10. Polimorfismos del gen ob en bovinos de raza holstein en la Comarca Lagunera, México

    OpenAIRE

    Sarai S. Mendoza-Retana; Miguel A. Gallegos-Robles; Uriel González-Salas; José L. García-Hernández; Manuel Fortis-Hernández; Cirilo Vázquez-Vázquez; Héctor I. Trejo-Escareño

    2017-01-01

    La Comarca Lagunera es la cuenca lechera más importante de México. En la actualidad se están utilizando diversas técnicas que permiten evaluar genéticamente el animal a una edad temprana, permitiendo seleccionar futuros reproductores con características deseables. Entre los genes relacionados con la producción de leche, se encuentran el gen Ob también llamado gen Leptina el cual actúa sobre el sistema nervioso central y tejidos periféricos jugando un papel muy importante ...

  11. Enhanced glucose cycling and suppressed de novo synthesis of glucose-6-phosphate result in a net unchanged hepatic glucose output in ob/ob mice

    NARCIS (Netherlands)

    Bandsma, RHJ; Grefhorst, A; van Dijk, TH; van der Sluijs, FH; Hammer, A; Reijngoud, DJ; Kuipers, F

    2004-01-01

    Aims/hypothesis. Leptin-deficient ob/ob mice are hyperinsulinaemic and hyperglycaemic; however, the cause of hyperglycaemia remains largely unknown. Methods. Glucose metabolism in vivo in 9-h fasted ob/ob mice and lean littermates was studied by infusing [U-C-13]-glucose, [2-C-13]-glycerol,

  12. Leptin Increases Striatal Dopamine D2 Receptor Binding in Leptin-Deficient Obese (ob/ob) Mice

    Energy Technology Data Exchange (ETDEWEB)

    Pfaffly, J.; Michaelides, M.; Wang, G-J.; Pessin, J.E.; Volkow, N.D.; Thanos, P.K.

    2010-06-01

    Peripheral and central leptin administration have been shown to mediate central dopamine (DA) signaling. Leptin-receptor deficient rodents show decreased DA D2 receptor (D2R) binding in striatum and unique DA profiles compared to controls. Leptin-deficient mice show increased DA activity in reward-related brain regions. The objective of this study was to examine whether basal D2R-binding differences contribute to the phenotypic behaviors of leptin-deficient ob/ob mice, and whether D2R binding is altered in response to peripheral leptin treatment in these mice. Leptin decreased body weight, food intake, and plasma insulin concentration in ob/ob mice but not in wild-type mice. Basal striatal D2R binding (measured with autoradiography [{sup 3}H] spiperone) did not differ between ob/ob and wild-type mice but the response to leptin did. In wild-type mice, leptin decreased striatal D2R binding, whereas, in ob/ob mice, leptin increased D2R binding. Our findings provide further evidence that leptin modulates D2R expression in striatum and that these effects are genotype/phenotype dependent.

  13. Reverse time migration of multiples for OBS data

    KAUST Repository

    Zhang, Dongliang

    2014-01-01

    Reverse time migration of multiples (RTMM) is applied to OBS data with sparse receiver spacing. RTMM for OBS data unlike a marine streamer acquisition is implemented in the common receiver gathers (CRG) and provides a wider and denser illumination for each CRG than the conventional RTM of primaries. Hence, while the the conventional RTM image contains strong aliasing artifacts due to a sparser receiver interval, the RTMM image suffers from this artifacts less. This benefit of RTMM is demonstrated with numerical test on the Marmousi model for sparsely sampled OBS data.

  14. Searching for self-enrichment in Cygnus OB2

    Science.gov (United States)

    Berlanas, Sara R.; Herrero, Artemio; Comerón, Fernando; Pasquali, Anna; Simón-Díaz, Sergio

    2017-11-01

    Cygnus OB2 is a rich and relatively close (d~1.4 kpc) OB association in our Galaxy. It represents an ideal testbed for our theories about self-enrichment processes produced by pollution of the interstellar medium by successive generations of massive stars. Comerón & Pasquali (2012, A&A, 543, A101) found a correlation between the age of young stellar groups in Cygnus OB2 and their Galactic longitude. If is associated with a chemical composition gradient, it could support these self-enrichment processes.

  15. Reverse time migration of multiples for OBS data

    KAUST Repository

    Zhang, Dongliang

    2014-08-05

    Reverse time migration of multiples (RTMM) is applied to OBS data with sparse receiver spacing. RTMM for OBS data unlike a marine streamer acquisition is implemented in the common receiver gathers (CRG) and provides a wider and denser illumination for each CRG than the conventional RTM of primaries. Hence, while the the conventional RTM image contains strong aliasing artifacts due to a sparser receiver interval, the RTMM image suffers from this artifacts less. This benefit of RTMM is demonstrated with numerical test on the Marmousi model for sparsely sampled OBS data.

  16. New Results on the Nearest OB Association: Sco-Cen (Sco OB2)

    Science.gov (United States)

    Mamajek, Eric E.

    2013-01-01

    The Scorpius-Centaurus OB association (Sco OB2) is the nearest site of recent massive star formation to the Sun. The primary stellar groups in the Sco-Cen complex (including OB subgroups Upper Sco, Upper Cen Lup, and Lower Cen Cru, the neighboring molecular cloud complexes Lup, Cha, CrA, Oph, and dispersed young groups Eta Cha, Epsilon Cha, TW Hya, and Beta Pic) have been participants in a complex episode of stellar birth (and some stellar death) over the past ~20 Myr. Here I summarize some recent results on the Sco-Cen complex from the U. Rochester group: (1) isochronal analysis of the HR diagram positions for >1 Msun stars in the Upper Scorpius subgroup shows it to be twice as old as previously thought (11 Myr vs. 5 Myr), (2) analysis of high resolution optical echelle spectra show that the subgroups are approximately solar in composition, (3) surveys for lower mass members are showing that the complex shows more substructure than previously recognized, including at least one new subgroup ("Lower Sco"), and the velocity and age data for the nearest OB subgroup Lower Cen Cru argue for a bifurcation into a younger 10 Myr) southern part ("Crux") and an older 20 Myr) northern part ("Lower Centaurus"), (4) an eclipsing, multi-ring dust disk system was serendipitously discovered in the SuperWASP and ASAS light curve for the newly discovered K5-type Sco-Cen member 1SWASP J140747.93-394542.6. With regard to some recent results by other investigators, we find that (1) attempts by some authors to subsume the Sco-Cen subgroups into a single sample of a single age are unnecessarily mixing samples with a wide range in ages, and (2) I have been unable to replicate the expansion age determinations claimed by some investigators for the TW Hya and Beta Pic groups (both purported to have expansion ages of 8 and 12 Myr, respectively), which have been used by some investigators to independently age-date the Sco-Cen subgroups. We acknowledge support from NSF grant AST-1008908 and the

  17. A Novel Congestion Detection Scheme in TCP Over OBS Networks

    KAUST Repository

    Shihada, Basem; Ho, Pin-Han; Zhang, Qiong

    2009-01-01

    This paper introduces a novel congestion detection scheme for high-bandwidth TCP flows over optical burst switching (OBS) networks, called statistical additive increase multiplicative decrease (SAIMD). SAIMD maintains and analyzes a number

  18. Evidence for circumstellar obscuration of OB stars

    International Nuclear Information System (INIS)

    Bohannan, B.

    1975-01-01

    Reddish found a strong increase of color excess with increasing stellar luminosity: here referred to as the Reddish Effect: in ten young galactic clusters and associations. New photometric and spectroscopic observations drawn from the literature are combined with data used by Reddish to reconsider the color excess versus intrinsic magnitude diagrams of the same ten stellar groups. The reality of the Effect is questioned in all but one of the systems; this was accomplished by identifying possible foreground stars and by recognizing some of the brightest stars as supergiants, then applying correct intrinsic color indices. After careful reanalysis, the one stellar group to retain an indication of the Reddish Effect is Cygnus OB2. No correlation of reddening with luminosity was found for five additional very young stellar groups in the southern hemisphere; these groups should exhibit the Effect if it is a natural consequence of stellar evolution. Reddish ascribed the correlation to massive circumstellar remnants of material from which the stars formed. However, a peculiar dispersion in color excess could also be attributed to patchy dust within the stellar group. In several stellar systems previously identified as displaying the Reddish Effect, a correlation of observed color excess with dust and gas concentrations is noted on Palomar Sky Survey prints. If present, circumstellar dust clouds should []anifest their existence in modes other than a correlation of color excess with luminosity. The following possibilities are considered and all show negative results: correlation of color excess with spectral type; correlation of reddening slope E/subU//sub -//subB//E/subB//sub -//subV/ with spectral type; observable infrared excess. The preceding astrophysical arguments strongly imply that circumstellar dust remnants from stellar formation do not remain around stars during their main-sequence lifetimes. (auth)

  19. Impaired transport of thyroid hormones into livers of obese (ob/ob) mice

    International Nuclear Information System (INIS)

    Hillgartner, F.B.; Romsos, D.R.

    1988-01-01

    Obese (ob/ob) mice exhibit impaired hepatic thyroid hormone action that is mediated, at least in part, by a reduced nuclear 3,5,3'-triiodothyronine (T 3 ) receptor occupancy. The possibility that lowered occupancy in obese mice may be caused by decreased transport of T 3 across the hepatic plasma membrane was examined by measuring the unidirectional influx of [ 125 I]T 3 into livers of 8- to 10-wk-old obese and lean mice using a tissue-sampling portal vein-injection technique. Influx of [ 125 I]thyroxine (T 4 ), a substrate for T 4 5'-deiodinase, was also measured. Unidirectional clearance of T 3 and T 4 was 64 and 80% lower, respectively, in obese mice than in lean mice. Hepatic T 3 and T 4 uptake was nonsaturable in both lean and obese mice, suggesting that transport occurs by lipid-mediated free diffusion. Clearance of another lipid-soluble hormone, hydrocortisone, was also lower in obese mice than in lean mice. Decreased membrane permeability to the above hormones in obese mice may result from reported changes in membrane lipid composition. In conclusion, decreased hepatic thyroid hormone uptake may contribute to impaired thyroid hormone action and T 3 production in livers of obese mice

  20. Nuclear triiodothyronine receptor binding characteristics and occupancy in obese (ob/ob) mice

    International Nuclear Information System (INIS)

    Hillgartner, F.B.; Romsos, D.R.

    1987-01-01

    Obese (ob/ob) mice exhibit reduced adaptive thermogenesis associated with an impairment of thyroid hormone action. The mechanism underlying the latter defect was investigated by comparing the binding characteristics and occupancy of solubilized nuclear 3,5,3'-triiodothyronine (T 3 ) receptors from livers of lean and obese mice. T 3 concentration was measured by radioimmunoassay. Scatchard analysis showed minimal differences in B/sub max/ and K/sub d/ between phenotypes at both 4 and 8-10 wk of age, indicating that reduced hepatic thyroid hormone expression in obese mice is not caused by alterations in nuclear receptor concentration or affinity. In contrast, nuclear T 3 receptor occupancy (endogenous T 3 associated with the specific receptor divided by B/sub max/) was 14 and 23% lower in 4- and 8- to 10-wk old obese mice, respectively. Together with reported changes in hepatic thyroid hormone-sensitive enzymes, these data are consistent with a diminished nuclear T 3 signal initiating thyroid hormone action in obese mice. Decreased nuclear T 3 receptor occupancy may be secondary to a low transport of plasma T 3 to the nuclear pool. In conclusion, impaired hepatic thyroid hormone action in obese mice is mediated in part at least by a reduction in nuclear T 3 receptor occupancy

  1. Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice.

    Science.gov (United States)

    Chen, H-L; Tung, Y-T; Tsai, C-L; Lai, C-W; Lai, Z-L; Tsai, H-C; Lin, Y-L; Wang, C-H; Chen, C-M

    2014-09-01

    Fatty liver disease is commonly associated with obesity, insulin resistance and diabetes. Severe fatty liver is sometimes accompanied by steatohepatitis and may lead to the development of hepatocellular carcinoma. At present, there is no effective treatment for non-alcoholic fatty liver disease (NAFLD); thus, recent investigations have focused on developing effective therapeutics to treat this condition. This study aimed to evaluate the effects of kefir on the hepatic lipid metabolism of ob/ob mice, which are commonly used to model fatty liver disease. In this study, we used leptin receptor-deficient ob/ob mice as an animal disease model of NAFLD. Six-week-old ob/ob mice were orally administered the dairy product kefir (140 mg kg(-1) of body weight (BW) per day) for 4 weeks. The data demonstrated that kefir improved fatty liver syndrome on BW, energy expenditure and basal metabolic rate by inhibiting serum glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) activities (Pkefir administration also significantly reduced the macrovesicular fat quantity in liver tissue. In addition, kefir markedly decreased the expression of the genes sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) (Pkefir improves NAFLD on BW, energy expenditure and basal metabolic rate by inhibiting the lipogenesis pathway and that kefir may have the potential for clinical application to the prevention or treatment of NAFLD.

  2. Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lepob/ob mice

    International Nuclear Information System (INIS)

    Sekiya, Motohiro; Yahagi, Naoya; Tamura, Yoshiaki; Okazaki, Hiroaki; Igarashi, Masaki; Ohta, Keisuke; Takanashi, Mikio; Kumagai, Masayoshi; Takase, Satoru; Nishi, Makiko; Takeuchi, Yoshinori; Izumida, Yoshihiko; Kubota, Midori; Ohashi, Ken; Iizuka, Yoko; Yagyu, Hiroaki; Gotoda, Takanari; Nagai, Ryozo; Shimano, Hitoshi; Yamada, Nobuhiro

    2009-01-01

    It has long been a matter of debate whether the hormone-sensitive lipase (HSL)-mediated lipolysis in pancreatic β-cells can affect insulin secretion through the alteration of lipotoxicity. We generated mice lacking both leptin and HSL (Lep ob/ob /HSL -/- ) and explored the role of HSL in pancreatic β-cells in the setting of obesity. Lep ob/ob /HSL -/- developed elevated blood glucose levels and reduced plasma insulin levels compared with Lep ob/ob /HSL +/+ in a fed state, while the deficiency of HSL did not affect glucose homeostasis in Lep +/+ background. The deficiency of HSL exacerbated the accumulation of triglycerides in Lep ob/ob islets, leading to reduced glucose-stimulated insulin secretion. The deficiency of HSL also diminished the islet mass in Lep ob/ob mice due to decreased cell proliferation. In conclusion, HSL affects insulin secretary capacity especially in the setting of obesity.

  3. Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High Fat Diets

    Directory of Open Access Journals (Sweden)

    Laurence B Lindenmaier

    2016-08-01

    Full Text Available Low bone mass is often associated with increased bone marrow adiposity. Since osteoblasts and adipocytes are derived from the same mesenchymal stem cell progenitor, adipocyte formation may increase at the expense of osteoblast formation. Leptin is an adipocyte-derived hormone known to regulate energy and bone metabolism. Genetic (e.g., leptin deficiency and high fat diet-induced (e.g., leptin resistance obesity are associated with increased marrow adipose tissue (MAT and reduced bone formation. Short-duration studies suggest that leptin treatment reduces MAT and increases bone formation in leptin-deficient ob/ob mice fed a regular diet. Here, we determined the long-duration impact of increased hypothalamic leptin on marrow adipocytes and osteoblasts in ob/ob mice using recombinant adeno-associated virus (rAAV gene therapy. In a first study, eight- to ten-week-old male ob/ob mice were randomized into 4 groups: (1 untreated, (2 rAAV-Lep, (3 rAAV-green fluorescent protein (rAAV-GFP, or (4 pair-fed to rAAV-Lep. For vector administration, mice were placed in a Kopf stereotaxic apparatus, and injected intracerebroventricularly with either rAAV-Lep or rAAV-GFP (9 × 107 particles in 1.5 µl. The mice were maintained for 30 weeks following vector administration. In a second study, the impact of increased hypothalamic leptin levels on MAT was determined in mice fed high fat diets. Eight- to ten-week-old male ob/ob mice were randomized into 2 groups and treated with either rAAV-Lep or rAAV-GFP. At 7 weeks post-vector administration, half the mice in each group were switched to a high fat diet for 8 weeks. Wild type (WT controls included age-matched mice fed regular or high fat diet. Hypothalamic leptin gene therapy increased osteoblast perimeter and osteoclast perimeter with minor change in cancellous bone architecture. The gene therapy decreased MAT levels in ob/ob mice fed regular or high fat diet to values similar to WT mice fed regular diet. These

  4. Obs4MIPS: Satellite Observations for Model Evaluation

    Science.gov (United States)

    Ferraro, R.; Waliser, D. E.; Gleckler, P. J.

    2017-12-01

    This poster will review the current status of the obs4MIPs project, whose purpose is to provide a limited collection of well-established and documented datasets for comparison with Earth system models (https://www.earthsystemcog.org/projects/obs4mips/). These datasets have been reformatted to correspond with the CMIP5 model output requirements, and include technical documentation specifically targeted for their use in model output evaluation. The project holdings now exceed 120 datasets with observations that directly correspond to CMIP5 model output variables, with new additions in response to the CMIP6 experiments. With the growth in climate model output data volume, it is increasing more difficult to bring the model output and the observations together to do evaluations. The positioning of the obs4MIPs datasets within the Earth System Grid Federation (ESGF) allows for the use of currently available and planned online tools within the ESGF to perform analysis using model output and observational datasets without necessarily downloading everything to a local workstation. This past year, obs4MIPs has updated its submission guidelines to closely align with changes in the CMIP6 experiments, and is implementing additional indicators and ancillary data to allow users to more easily determine the efficacy of an obs4MIPs dataset for specific evaluation purposes. This poster will present the new guidelines and indicators, and update the list of current obs4MIPs holdings and their connection to the ESGF evaluation and analysis tools currently available, and being developed for the CMIP6 experiments.

  5. Mining the Obscured OB Star Population in Carina

    Science.gov (United States)

    Smith, Michael

    2016-04-01

    Massive OB stars are very influential objects in the ecology of galaxies like our own. Current catalogues of Galactic OB stars are heavily biased towards bright (g selected OB stars across the entire Southern Galactic plane, both within clusters and in the field, down to ∼20th magnitude in g. For the first time, a complete accounting of the OB star runaway phenomenon becomes possible. Along with making the primary selection using VPHAS+ colours, I have performed Markov-Chain Monte Carlo fitting of the spectral energy distributions of the selected stars by combining VPHAS+ u, g, r, i with published J, H, K photometry. This gives rough constraints on effective temperature and distance, whilst delivering much more precise reddening parameters A0 and RV - allowing us to build a much richer picture of how extinction and extinction laws vary across the Galactic Plane. My thesis begins with a description of the method of photometric selection of OB star candidates and its validation across a 2 square degree field including the well-known young massive star cluster Westerlund 2 (Mohr-Smith et al., 2015). Following on from this I present spectroscopy with AAOmega of 283 candidates identified by our method, which confirms that ∼94% of the sample are the expected O and early B stars. I then develop this method further and apply it to a Galactic Plane strip of 42 square-degrees that runs from the Carina Arm tangent region to the much studied massive cluster in NGC 3603. A new aspect I attend to in this expansion of method is tightening up the uniform photometric calibration of the data, paying particular attention to the always-challenging u band. This leads to a new and reliable catalogue of 5915 OB stars. As well as increasing the numbers of identified massive stars in this large region of the sky by nearly an order of magnitude, a more complete picture of massive star formation in the Carina Arm has emerged. I have found a broad over-density of O stars around the highly

  6. Recent Seismic Experiments of OBS in the South China Sea

    Science.gov (United States)

    Ruan, A.; Li, J.; Wu, Z.

    2012-12-01

    Since 2006 some research institutions of China have carried out some important seismic experiments by using ocean bottom seismometer(OBS) in the South China Sea (SCS) and obtained many concrete progresses in modeling the crustal structure of SCS and also in understanding of its formation and evolution as well. In 2006 three wide-angle profiles were completed in the northern margin, named OBS2006-1 across the northwestern sub-basin, OBS2006-2 parallel to the sea basin boundary and OBS2006-3 across the Dongsha Rise and Chaoshan Depression respectively. In 2010 two wide- angle profiles were completed, named OBS2010-1 and OBS 2010-2 both perpendicular to the northern off-shore faulting system. During 2009-2011 four wide-angle profiles were completed in the southern margin, named OBS973-1 from southern margin to the southwestern sub-basin, OBS973-2 from Liyue Bank to the southwestern sub-basin and OBS973-3 from Xisha to the southwestern sub-basin, OBS2011-2 from Xisha to Hainan Island respectively. In 2011 two 3D seismic array of OBS were completed in the Zhongnan-Changlong sea mount chain and Huangyan-Zhenbei sea mount chain respectively. Here we present some primary but important results as follows. (1) The velocity model of OBS2006-1 indicates that the crust under the continental slope decreases from 21km to 11km, and to 7.7km in the northwestern sub-basin with Moho depth ascends from 21km to 11km. The tectonic geometry and velocity structure of the northwestern sub-basin and its margins on both sides shows symmetrical and conjugate and indicates pure shear mode of continental margin rifting mechanism. (2) The velocity model of OBS2006-3 reveals remarkable thickness with maximum 8 km of the Mesozoic sediment in Chaoshan Depression in which velocity increases downward from 4.4 km/s at top to 5.3 km/s at the bottom. The buried depth of Moho decreases from 24-25 km under Dongsha Rise to 17 km in the lower slope and an obviously velocity abnormal is detected in the upper

  7. Expression of Leptin (Ob Gene Product) in Reproductive System ...

    African Journals Online (AJOL)

    Purpose: To determine serum leptin and its ob mRNA expression both in the PCOS and non-PCOS ovary, endometrium and adipose tissue in normal or polycystic ovary syndrome (PCOS) in South Indian population. PCOS (Polycystic Ovary Syndrome) and non-PCOS subject's endometrium, ovary and adipose tissue were ...

  8. iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling.

    Science.gov (United States)

    Deng, Xiuling; Wang, Jiliang; Jiao, Li; Utaipan, Tanyarath; Tuma-Kellner, Sabine; Schmitz, Gerd; Liebisch, Gerhard; Stremmel, Wolfgang; Chamulitrat, Walee

    2016-05-01

    PLA2G6 or GVIA calcium-independent PLA2 (iPLA2β) is identified as one of the NAFLD modifier genes in humans, and thought to be a target for NAFLD therapy. iPLA2β is known to play a house-keeping role in phospholipid metabolism and remodeling. However, its role in NAFLD pathogenesis has not been supported by results obtained from high-fat feeding of iPLA2β-null (PKO) mice. Unlike livers of human NAFLD and genetically obese rodents, fatty liver induced by high-fat diet is not associated with depletion of hepatic phospholipids. We therefore tested whether iPLA2β could regulate obesity and hepatic steatosis in leptin-deficient mice by cross-breeding PKO with ob/ob mice to generate ob/ob-PKO mice. Here we observed an improvement in ob/ob-PKO mice with significant reduction in serum enzymes, lipids, glucose, insulin as well as improved glucose tolerance, and reduction in islet hyperplasia. The improvement in hepatic steatosis measured by liver triglycerides, fatty acids and cholesterol esters was associated with decreased expression of PPARγ and de novo lipogenesis genes, and the reversal of β-oxidation gene expression. Notably, ob/ob livers contained depleted levels of lysophospholipids and phospholipids, and iPLA2β deficiency in ob/ob-PKO livers lowers the former, but replenished the latter particularly phosphatidylethanolamine (PE) and phosphatidylcholine (PC) that contained arachidonic (AA) and docosahexaenoic (DHA) acids. Compared with WT livers, PKO livers also contained increased PE and PC containing AA and DHA. Thus, iPLA2β deficiency protected against obesity and ob/ob fatty liver which was associated with hepatic fatty-acyl phospholipid remodeling. Our results support the deleterious role of iPLA2β in severe obesity associated NAFLD. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Leptin Reduces the Expression and Increases the Phosphorylation of the Negative Regulators of GLUT4 Traffic TBC1D1 and TBC1D4 in Muscle of ob/ob Mice

    Science.gov (United States)

    Sáinz, Neira; Rodríguez, Amaia; Catalán, Victoria; Becerril, Sara; Ramírez, Beatriz; Lancha, Andoni; Burgos-Ramos, Emma; Gómez-Ambrosi, Javier; Frühbeck, Gema

    2012-01-01

    Leptin improves insulin sensitivity in skeletal muscle. Our goal was to determine whether proteins controlling GLUT4 traffic are altered by leptin deficiency and in vivo leptin administration in skeletal muscle of wild type and ob/ob mice. Leptin-deficient ob/ob mice were divided in three groups: control, leptin-treated (1 mg/kg/d) and leptin pair-fed ob/ob mice. Microarray analysis revealed that 1,546 and 1,127 genes were regulated by leptin deficiency and leptin treatment, respectively. Among these, we identified 24 genes involved in intracellular vesicle-mediated transport in ob/ob mice. TBC1 domain family, member 1 (Tbc1d1), a negative regulator of GLUT4 translocation, was up-regulated (P = 0.001) in ob/ob mice as compared to wild types. Importantly, leptin treatment reduced the transcript levels of Tbc1d1 (P<0.001) and Tbc1d4 (P = 0.004) in the leptin-treated ob/ob as compared to pair-fed ob/ob animals. In addition, phosphorylation levels of TBC1D1 and TBC1D4 were enhanced in leptin-treated ob/ob as compared to control ob/ob (P = 0.015 and P = 0.023, respectively) and pair-fed ob/ob (P = 0.036 and P = 0.034, respectively) mice. Despite similar GLUT4 protein expression in wild type and ob/ob groups a different immunolocalization of this protein was evidenced in muscle sections. Leptin treatment increased GLUT4 immunoreactivity in gastrocnemius and extensor digitorum longus sections of leptin-treated ob/ob mice. Moreover, GLUT4 protein detected in immunoprecipitates from TBC1D4 was reduced by leptin replacement compared to control ob/ob (P = 0.013) and pair-fed ob/ob (P = 0.037) mice. Our findings suggest that leptin enhances the intracellular GLUT4 transport in skeletal muscle of ob/ob animals by reducing the expression and activity of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4. PMID:22253718

  10. Radio observations of the CMa OB1 H II regions

    International Nuclear Information System (INIS)

    Gaylard, M.J.; Kemball, A.J.

    1984-01-01

    A sensitive 10 0 x 15 0 13-cm map made of the CMa OB1 H II regions' radio emission shows a strong similarity to Hα emission photographs. Sharpless 296 is shown to consist of a prominent central and western arc completed by a weaker southern loop, and with a faint northern bar. The emission is thermal, superimposed over a predominantly non-thermal background. The H142α recombination line has been detected at eight positions in S296, and in S292 and S297. The average electron temperature in S296 is 6900 +- 1300 K. The UV fluxes from the CMa OB1 stars account for the observed emission measures of the H II regions. The H142α 1sr velocities indicate that the ionized material is in contact with the molecular clouds. (author)

  11. Neutral hydrogen in the stellar accociation Scorpius OB-2

    Energy Technology Data Exchange (ETDEWEB)

    Bystrova, N.V.

    1979-01-01

    The distribution of neutral hydrogen connected with the stellar association Scorpius OB-2 is more complex than the expanding semienvelope suggested earlier. The neutral gas is in connection with the nebulae S1, S7, S9 and with H/sub ..cap alpha../-filaments found in the association and giving it the appearence of a spiral galaxy. The HI-distribution is in disagreement with the model of a supernova remnant.

  12. Variability of X-ray emission from OB stars

    International Nuclear Information System (INIS)

    Collura, A.; Sciortino, S.; Serio, S.; Vaiana, G. S.; Harnden, F.R. JR.; Osservatorio Astronomico, Palermo, Italy; Harvard-Smithsonian Center for Astrophysics, Cambridge, MA)

    1989-01-01

    The variability in soft X-ray emission of 12 OB stars is studied. Two different methods of analysis, one more suitable for detecting short-term variations, the other aimed at detecting long time-scale variations, are applied to all stars in the sample. The long-term variability analysis shows that Cyg-OB2 8A Zeta Pup and Delta Ori exhibit significant count rate variations between different data sections. Similar variations are marginally detected in 15 Mon; the count rate variations for the other eight stars are consistent with statistical fluctuations. The light curve of Cyg-OB2 8A suggests the existence of two different emission levels. The short-term variability analysis detects marginal variability in Tau Sco with an effective amplitude of about 30 percent and a time scale of about 50 s. The upper limits to the effective short-term variability amplitude for all other sample stars are in the 10-30 percent range. 30 refs

  13. ObsPy: A Python Toolbox for Seismology

    Science.gov (United States)

    Krischer, Lion; Megies, Tobias; Sales de Andrade, Elliott; Barsch, Robert; MacCarthy, Jonathan

    2017-04-01

    In recent years the Python ecosystem evolved into one of the most powerful and productive scientific environments across disciplines. ObsPy (https://www.obspy.org) is a fully community-driven, open-source project dedicated to providing a bridge for seismology into that ecosystem. It does so by offering Read and write support for essentially every commonly used data format in seismology with a unified interface and automatic format detection. This includes waveform data (MiniSEED, SAC, SEG-Y, Reftek, …) as well as station (SEED, StationXML, …) and event meta information (QuakeML, ZMAP, …). Integrated access to the largest data centers, web services, and real-time data streams (FDSNWS, ArcLink, SeedLink, ...). A powerful signal processing toolbox tuned to the specific needs of seismologists. Utility functionality like travel time calculations with the TauP method, geodetic functions, and data visualizations. ObsPy has been in constant development for more than seven years and is developed and used by scientists around the world with successful applications in all branches of seismology. Additionally it nowadays serves as the foundation for a large number of more specialized packages. This presentation will give a short overview of the capabilities of ObsPy and point out several representative or new use cases. Additionally we will discuss the road ahead as well as the long-term sustainability of open-source scientific software.

  14. OBS Technologies and permanent seismic Stations at Sea

    Science.gov (United States)

    Makris, J.; Nikolova, S. B.

    2003-04-01

    An off-shore telemetric system was developed during last 2 years. It consists of a buoy unit, OBS with seismic sensor and digitizer at the sea floor and coaxial cable for transferring data from the sea. The buoy unit includes all components for recording and transmitting data to the base station. A solar panel and wind generator are the sources of energy that charge the batteries in the buoy. An Omni directional antenna and a radio modem are used for data transfer. The buoy can be connected also to mobile network or satellite. The Seismic recording unit is SEDIS IV developed in GeoPro GmbH which is a 6 channel data logger equipped with a hard disk of 30 GByte capacity and a flash memory of 0.5 Gbyte which can continuously record at different sampling rate (from 31.25 to 1000sps). The operating system for SEDIS IV is LINUX, with possible data compression, event location and extraction. The data transfer and supply of the power to seismometer and ADC unit in OBS sphere is done through coaxial cable, connecting the buoy unit and OBS. The whole system was tested for a period of one month (October 2002) within frame of Nestor program in Pilos (Greece) and worked successfully.

  15. ADDITIONAL MASSIVE BINARIES IN THE CYGNUS OB2 ASSOCIATION

    International Nuclear Information System (INIS)

    Kiminki, Daniel C.; Kobulnicky, Henry A.; Ewing, Ian; Lundquist, Michael; Alexander, Michael; Vargas-Alvarez, Carlos; Choi, Heather; Bagley Kiminki, Megan M.; Henderson, C. B.

    2012-01-01

    We report the discovery and orbital solutions for two new OB binaries in the Cygnus OB2 Association, MT311 (B2V + B3V) and MT605 (B0.5V + B2.5:V). We also identify the system MT429 as a probable triple system consisting of a tight eclipsing 2.97 day B3V+B6V pair and a B0V at a projected separation of 138 AU. We further provide the first spectroscopic orbital solutions to the eclipsing, double-lined, O-star binary MT696 (O9.5V + B1:V), the double-lined, early B binary MT720 (B0-1V + B1-2V), and the double-lined, O-star binary MT771 (O7V + O9V). These systems exhibit orbital periods between 1.5 days and 12.3 days, with the majority having P <6 days. The two new binary discoveries and six spectroscopic solutions bring the total number of known massive binaries in the central region of the Cygnus OB2 Association to 20, with all but two having full orbital solutions.

  16. ADDITIONAL MASSIVE BINARIES IN THE CYGNUS OB2 ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Kiminki, Daniel C.; Kobulnicky, Henry A.; Ewing, Ian; Lundquist, Michael; Alexander, Michael; Vargas-Alvarez, Carlos; Choi, Heather [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82070 (United States); Bagley Kiminki, Megan M. [Department of Astronomy, University of Arizona, Tucson, AZ 85721 (United States); Henderson, C. B. [Department of Astronomy, Ohio State University, Columbus, OH 43210 (United States)

    2012-03-01

    We report the discovery and orbital solutions for two new OB binaries in the Cygnus OB2 Association, MT311 (B2V + B3V) and MT605 (B0.5V + B2.5:V). We also identify the system MT429 as a probable triple system consisting of a tight eclipsing 2.97 day B3V+B6V pair and a B0V at a projected separation of 138 AU. We further provide the first spectroscopic orbital solutions to the eclipsing, double-lined, O-star binary MT696 (O9.5V + B1:V), the double-lined, early B binary MT720 (B0-1V + B1-2V), and the double-lined, O-star binary MT771 (O7V + O9V). These systems exhibit orbital periods between 1.5 days and 12.3 days, with the majority having P <6 days. The two new binary discoveries and six spectroscopic solutions bring the total number of known massive binaries in the central region of the Cygnus OB2 Association to 20, with all but two having full orbital solutions.

  17. Star formation in the Monoceros OB1 dark cloud

    International Nuclear Information System (INIS)

    Margulis, M.S.

    1987-01-01

    A survey of the Monoceros OB1 dark cloud was made for molecular outflows and young stellar objects. In all, nine molecular outflows and thirty far-infrared sources were identified in a portion of the cloud composed of about 3 x 10 4 M of material. Statistical arguments suggest that 90% of the far-infrared sources actually are young stellar objects embedded in the cloud. If the star formation rate in the Mon OB1 cloud is roughly constant with time, then molecular outflows in the cloud should be able to support it against collapse due to gravity. This suggests that the birthrate of outflows in the solar neighborhood is very high. In fact, regardless of considerations of cloud support, the large number of outflows identified in the Mon OB1 cloud and the propensity of the youngest stellar objects in the cloud to be associated with outflows suggest that outflows have a high birthrate in the solar neighborhood and are part of a common stage in early stellar evolution. The young stellar objects identified in the cloud can be fit into a spectral classification system. Also, the outflow phase in early stellar evolution tends to occur at about the time that young stellar objects lose a large fraction of their circumstellar envelopes

  18. Determining OBS Instrument Orientations: A Comparison of Algorithms

    Science.gov (United States)

    Doran, A. K.; Laske, G.

    2015-12-01

    The alignment of the orientation of the horizontal seismometer components with the geographical coordinate system is critical for a wide variety of seismic analyses, but the traditional deployment method of ocean bottom seismometers (OBS) precludes knowledge of this parameter. Current techniques for determining the orientation predominantly rely on body and surface wave data recorded from teleseismic events with sufficiently large magnitudes. Both wave types experience lateral refraction between the source and receiver as a result of heterogeneity and anisotropy, and therefore the arrival angle of any one phase can significantly deviate from the great circle minor arc. We systematically compare the results and uncertainties obtained through current determination methods, as well as describe a new algorithm that uses body wave, surface wave, and differential pressure gauge data (where available) to invert for horizontal orientation. To start with, our method is based on the easily transportable computer code of Stachnik et al. (2012) that is publicly available through IRIS. A major addition is that we utilize updated global dispersion maps to account for lateral refraction, as was done by Laske (1995). We also make measurements in a wide range of frequencies, and analyze surface wave trains of repeat orbits. Our method has the advantage of requiring fewer total events to achieve high precision estimates, which is beneficial for OBS deployments that can be as short as weeks. Although the program is designed for the purpose of use with OBS instruments, it also works with standard land installations. We intend to provide the community with a program that is easy to use, requires minimal user input, and is optimized to work with data cataloged at the IRIS DMC.

  19. A Search for Pulsar Companions to OB Runaway Stars

    Science.gov (United States)

    Kaspi, V. M.

    1995-01-01

    We have searched for radio pulsar companions to 40 nearby OB runaway stars. Observations were made at 474 and 770 MHz with the NRAO 140 ft telescope. The survey was sensitive to long- period pulsars with flux densities of 1 mJy or more. One previously unknown pulsar was discovered, PSRJ2044+4614, while observing towards target O star BD+45,3260. Follow-up timing observations of the pulsar measured its position to high precision, revealing a 9' separation between the pulsar and the target star, unequivocally indicating they are not associated.

  20. ObsPy - A Python Toolbox for Seismology - and Applications

    Science.gov (United States)

    Krischer, L.; Megies, T.; Barsch, R.; MacCarthy, J.; Lecocq, T.; Koymans, M. R.; Carothers, L.; Eulenfeld, T.; Reyes, C. G.; Falco, N.; Sales de Andrade, E.

    2017-12-01

    Recent years witnessed the evolution of Python's ecosystem into one of the most powerful and productive scientific environments across disciplines. ObsPy (https://www.obspy.org) is a fully community driven, open-source project dedicated to provide a bridge for seismology into that ecosystem. It is a Python toolbox offering: Read and write support for essentially every commonly used data format in seismology with a unified interface and automatic format detection. This includes waveform data (MiniSEED, SAC, SEG-Y, Reftek, …) as well as station (SEED, StationXML, SC3ML, …) and event meta information (QuakeML, ZMAP, …). Integrated access to the largest data centers, web services, and real-time data streams (FDSNWS, ArcLink, SeedLink, ...). A powerful signal processing toolbox tuned to the specific needs of seismologists. Utility functionality like travel time calculations with the TauP method, geodetic functions, and data visualizations. ObsPy has been in constant development for more than eight years and is developed and used by scientists around the world with successful applications in all branches of seismology. Additionally it nowadays serves as the foundation for a large number of more specialized packages. Newest features include: Full interoperability of SEED and StationXML/Inventory objects Access to the Nominal Response Library (NRL) for easy and quick creation of station metadata from scratch Support for the IRIS Federated Catalog Service Improved performance of the EarthWorm client Several improvements to MiniSEED read/write module Improved plotting capabilities for PPSD (spectrograms, PSD of discrete frequencies over time, ..) Support for.. Reading ArcLink Inventory XML Reading Reftek data format Writing SeisComp3 ML (SC3ML) Writing StationTXT format This presentation will give a short overview of the capabilities of ObsPy and point out several representative or new use cases and show-case some projects that are based on ObsPy, e.g.: seismo

  1. Modelling of slag emulsification and slag reduction in CAS-OB process

    OpenAIRE

    Sulasalmi, P. (Petri)

    2016-01-01

    Abstract Composition Adjustment by Sealed argon bubbling – Oxygen Blowing (CAS-OB) process is a ladle treatment process that was developed for chemical heating and alloying of steel. The main stages of the process are heating, (possible) alloying and reduction of slag. The CAS-OB process aims for homogenization and control of the composition and temperature of steel. In this dissertation, a mathematical reaction model was developed for the slag reduction stage of the CAS-OB process. Sl...

  2. The Seismic Broad Band Western Mediterranean (wm) Network and the Obs Fomar Pool: Current state and Obs activities.

    Science.gov (United States)

    Pazos, Antonio; Davila, Jose Martin; Buforn, Elisa; Bezzeghoud, Mourad; Harnafi, Mimoun; Mattesini, Mauricio; Caldeira, Bento; Hanka, Winfried; El Moudnib, Lahcen; Strollo, Angelo; Roca, Antoni; Lopez de Mesa, Mireya; Dahm, Torsten; Cabieces, Roberto

    2016-04-01

    The Western Mediterranean (WM) seismic network started in 1996 as an initiative of the Royal Spanish Navy Observatory (ROA) and the Universidad Complutense de Madrid (UCM), with the collaboration of the GeoForschungsZentrum (GFZ) of Potsdam. A first broad band seismic station (SFUC) was installed close to Cádiz (South Spain). Since then, additional stations have been installed in the Ibero-Moghrebian region. In 2005, the "WM" code was assigned by the FDSN and new partners were jointed: Evora University (UEVO, Portugal), the Scientifique Institute of Rabat (ISRABAT, Morocco), and GFZ. Now days, the WM network is composed by 15 BB stations, all of them with Streckaisen STS-2 or STS-2.5 sensors, Quanterra or Earthdata digitizers and SeiscomP. Most them have co-installed a permanent geodetic GPS stations, and some them also have an accelerometer. There are 10 stations deployed in Spanish territory (5 in the Iberian peninsula, 1 in Balearic islands and 4 in North Africa Spanish places) with VSAT or Internet communications, 2 in Portugal (one of them without real time), and 3 in Morocco (2 VSAT and 1 ADSL). Additionally, 2 more stations (one in South Spain and one in Morocco) will be installed along this year. Additionally ROA has deployed a permanent real time VBB (CMG-3T: 360s) station at the Alboran Island. Due to the fact that part of the seismic activity is located at marine areas, and also because of the poor geographic azimuthal coverage at some zones provided by the land stations (specially in the SW of the San Vicente Cape area), ROA and UCM have acquired six broad band "LOBSTERN" OBS, manufactured by KUM (Kiel, Germany), conforming the OBS FOMAR pool. Three of them with CMG-40T sensor and the other with Trillium 120. These OBS were deployed along the Gibraltar strait since January to November 2014 to study the microseismicity in the Gibraltar strait area. In September 2015 FOMAR network has been deployed in SW of the San Vicente Cape for 8 months as a part of

  3. Dietary Capsaicin Improves Glucose Homeostasis and Alters the Gut Microbiota in Obese Diabetic ob/ob Mice

    Directory of Open Access Journals (Sweden)

    Jun-Xian Song

    2017-08-01

    Full Text Available Background: The effects of capsaicin on obesity and glucose homeostasis are still controversial and the mechanisms underlying these effects remain largely unknown. This study aimed to investigate the potential relationship between the regulation of obesity and glucose homeostasis by dietary capsaicin and the alterations of gut microbiota in obese diabetic ob/ob mice.Methods: The ob/ob mice were subjected to a normal, low-capsaicin (0.01%, or high-capsaicin (0.02% diet for 6 weeks, respectively. Obesity phenotypes, glucose homeostasis, the gut microbiota structure and composition, short-chain fatty acids, gastrointestinal hormones, and pro-inflammatory cytokines were measured.Results: Both the low- and high-capsaicin diets failed to prevent the increase in body weight, adiposity index, and Lee's obesity index. However, dietary capsaicin at both the low and high doses significantly inhibited the increase of fasting blood glucose and insulin levels. These inhibitory effects were comparable between the two groups. Similarly, dietary capsaicin resulted in remarkable improvement in glucose and insulin tolerance. In addition, neither the low- nor high-capsaicin diet could alter the α-diversity and β-diversity of the gut microbiota. Taxonomy-based analysis showed that both the low- and high-capsaicin diets, acting in similar ways, significantly increased the Firmicutes/Bacteroidetes ratio at the phylum level as well as increased the Roseburia abundance and decreased the Bacteroides and Parabacteroides abundances at the genus level. Spearman's correlation analysis revealed that the Roseburia abundance was negatively while the Bacteroides and Parabacteroides abundances were positively correlated to the fasting blood glucose level and area under the curve by the oral glucose tolerance test. Finally, the low- and high-capsaicin diets significantly increased the fecal butyrate and plasma total GLP-1 levels, but decreased plasma total ghrelin, TNF-α, IL-1

  4. Genetic ablation of phosphatidylcholine transfer protein/StarD2 in ob/ob mice improves glucose tolerance without increasing energy expenditure.

    Science.gov (United States)

    Krisko, Tibor I; LeClair, Katherine B; Cohen, David E

    2017-03-01

    Phosphatidylcholine transfer protein (PC-TP; synonym StarD2) is highly expressed in liver and oxidative tissues. PC-TP promotes hepatic glucose production during fasting and aggravates glucose intolerance in high fat fed mice. However, because PC-TP also suppresses thermogenesis in brown adipose tissue (BAT), its direct contribution to obesity-associated diabetes in mice remains unclear. Here we examined the effects of genetic PC-TP ablation on glucose homeostasis in leptin-deficient ob/ob mice, which exhibit both diabetes and altered thermoregulation. Mice lacking both PC-TP and leptin (Pctp -/- ;ob/ob) were prepared by crossing Pctp -/- with ob/+ mice. Glucose homeostasis was assessed by standard assays, and energy expenditure was determined by indirect calorimetry using a comprehensive laboratory animal monitoring system, which also recorded physical activity and food intake. Body composition was determined by NMR and hepatic lipids by enzymatic assays. Core body temperature was measured using a rectal thermocouple probe. Pctp -/- ;ob/ob mice demonstrated improved glucose homeostasis, as evidenced by markedly improved glucose and pyruvate tolerance tests, without changes in insulin tolerance. However, there were no differences in EE at any ambient temperature. There were also no effects of PC-TP expression on physical activity, food intake or core body temperature. Improved glucose tolerance in Pctp -/- ;ob/ob mice in the absence of increases in energy expenditure or core body temperature indicates a direct pathogenic role for PC-TP in diabetes in leptin deficient mice. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Expressão do gene da leptina e seu receptor Ob-Rb no parênquima mamário de novilhas leiteiras Leptin and leptin receptor Ob-Rb gene expression in mammary parenchyma of dairy heifers

    Directory of Open Access Journals (Sweden)

    Betina Joyce Lew

    2012-05-01

    Full Text Available Objetivou-se com este trabalho avaliar os efeitos de uma dieta de alto nível de energia e proteína combinada com a aplicação de bST no perfil de expressão dos genes da leptina e de seu receptor Ob-Rb no parênquima mamário de novilhas leiteiras. Foram utilizadas amostras de parênquima mamário de 32 novilhas holandesas distribuídas aleatoriamente em quatro tratamentos (n=8: dieta com alto ou baixo teor de energia e proteína combinada ou não com a aplicação de bST. O delineamento utilizado foi em blocos casualizados com arranjo de tratamentos em esquema fatorial 2 × 2. A extração do RNA total das amostras de tecido foi feita e o nível de expressão gênica foi analisado por qRT-PCR utilizando-se o gene da glicuronidase β como controle, pelo método 2-ΔΔCt. Animais que receberam a dieta com alto conteúdo de energia e proteína apresentaram maior expressão de mRNA de leptina, com aumento de 56%, e menor expressão de mRNA do receptor Ob-Rb, com redução de 18%. Por outro lado, a aplicação de bST resultou em diminuição da expressão do mRNA de leptina e do receptor Ob-Rb em 74% e 23%, respectivamente. Não houve interação entre dieta e aplicação de bST. O aumento na expressão de leptina pode explicar, ao menos em parte, os efeitos negativos da dieta de alta energia e proteína, oferecida no período pré-púbere, sobre a produção de leite de novilhas leiteiras.The objective of this study was to examine the effects of a diet with high level of energy and protein, combined with bST injections, on leptin and leptin-receptor (Ob-Rb gene expression profile in the mammary parenchyma of dairy heifers. Mammary parenchyma samples from 32 Holstein heifers, randomly assigned to one of four treatments (n=8, were utilized: high or low energy and protein diet, with or without bST injection. The experiment was designed in randomized blocks and arranged in a 2 × 2 factorial arrangement. Total RNA was extracted from tissue samples

  6. Decreased triiodothyronine receptor binding in skeletal muscle nuclei and erythrocyte membranes of obese (ob/ob) mice

    International Nuclear Information System (INIS)

    Gilvary, E.P.

    1988-01-01

    Hindlimb skeletal muscle weights and binding of L-tri-iodothyronine (T 3 ) to isolated nuclei of this tissue were investigated in obese (ob/ob) mice and their lean littermates. Maximal binding capacities (Bmax) and dissociation constants (Kd) were determined by incubating isolated muscle nuclei with increasing conc. of 125 I-T 3 (0.4 nM to 4nM). At 12 wks. of age, although weighing substantially more, obese mice had only 55% as much muscle mass as their lean littermates. There was no phenotype effect observed for Kd, however, Bmax was significantly less for the obese mice. In a second experiment, a 16-wk. feeding study was conducted with 4 groups of mice according to the following design: lean mice fed rodent chow; obese mice fed rodent chow; obese mice, n-6 fatty acid (FA)-rich diet; and obese mice, n-3FA-rich diet. Erythrocyte T 3 receptor binding capacities were measured by incubating red cell ghosts from mice of these 4 groups with 125 I-T 3 . As with skeletal muscle nuclei there were no phenotype effects observed for Kd between any two groups. In contrasts obese mice fed chow and n-6FA-rich diets both exhibited lower Bmax than their lean counterparts, while no significant difference was observed between the latter group and the obese mice fed an n-3FA-rich diet. Bmax values of the n-6 group were also decreased compared to the n-3 group

  7. Polimorfismos del gen ob en bovinos de raza holstein en la Comarca Lagunera, México

    Directory of Open Access Journals (Sweden)

    Sarai S. Mendoza-Retana

    2017-01-01

    Full Text Available La Comarca Lagunera es la cuenca lechera más importante de México. En la actualidad se están utilizando diversas técnicas que permiten evaluar genéticamente el animal a una edad temprana, permitiendo seleccionar futuros reproductores con características deseables. Entre los genes relacionados con la producción de leche, se encuentran el gen Ob también llamado gen Leptina el cual actúa sobre el sistema nervioso central y tejidos periféricos jugando un papel muy importante en la modulación regulación del apetito, ganancia de peso vivo, incremento del metabolismo energético y el anabolismo muscular. Este trabajo se realizó para determinar el polimorfismo de longitud del fragmento de restricción ACI I de gen leptina en el exón 2 y correlacionarlo con los parámetros de producción y calidad de leche. Se recolectaron 100 muestra de sangre de vacas en producción del establo “Lácteos Florida” de Francisco I. Madero municipio de Coahuila, México con tres esta tus de producción: altas, medias y bajas La extracción de ADN se realizó por el método modificado de Salting - Out. Se realizó PCR del gen leptina originando un fragmento de 272 bp de longitud y se realizó PCR - RFLP con la enzima de restricción ACI I y secue nciación, correlacionando los genotipos TT, CT Y CC con tres estatus de producción de leche: altas, medias, bajas. El análisis estadístico indicó que las vacas portadoras del genotipo homocigoto (TT tienen un efecto significativo (P<0.01 con respecto a l as características de producción y calidad de leche ya que tuvieron un mayor consumo de alimento, ganancia de peso, además de una elevada producción de leche en comparación a los genotipos heterocigoto (CT y homocigoto (CC. Los resultados obtenidos muest ran que l a identificación molecular de polimorfismos del gen Ob puede usarse como herramienta de selección genética en bovinos de raza Holstein.

  8. Oral delivery of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics: Immunofluorescent localization in the mouse hypothalamus.

    Science.gov (United States)

    Anderson, Brian M; Jacobson, Lauren; Novakovic, Zachary M; Grasso, Patricia

    2017-06-01

    This study describes the localization of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics, in the hypothalamus of Swiss Webster and C57BL/6J wild-type mice, leptin-deficient ob/ob mice, and leptin-resistant diet-induced obese (DIO) mice. The mice were given [D-Leu-4]-OB3 or MA-[D-Leu-4]-OB3 in 0.3% dodecyl maltoside by oral gavage. Once peak serum concentrations were reached, the mice received a lethal dose of pentobarbital and were subjected to intracardiac perfusion fixation. The brains were excised, post-fixed in paraformaldehyde, and cryo-protected in sucrose. Free-floating frozen coronal sections were cut at 25-µm and processed for imaging by immunofluorescence microscopy. In all four strains of mice, dense staining was concentrated in the area of the median eminence, at the base and/or along the inner wall of the third ventricle, and in the brain parenchyma at the level of the arcuate nucleus. These results indicate that [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 cross the blood-brain barrier and concentrate in an area of the hypothalamus known to regulate energy balance and glucose homeostasis. Most noteworthy is the localization of [D-Leu-4]-OB3 immunoreactivity within the hypothalamus of DIO mice via a conduit that is closed to leptin in this rodent model, and in most cases of human obesity. Together with our previous studies describing the effects of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 on energy balance, glucose regulation, and signal transduction pathway activation, these findings are consistent with a central mechanism of action for these synthetic peptide leptin mimetics, and suggest their potential usefulness in the management of leptin-resistant obesity and type 2 diabetes in humans. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Mass loss rates of OB stars derived from infrared observations

    International Nuclear Information System (INIS)

    Tanzi, E.G.; Tarenghi, M.; Panagia, N.

    1981-01-01

    In this paper the authors report briefly on a study of the mass loss of early type stars in the infrared. Up to now near infrared (1.25 - 4.8 μ) broad band photometry of 70 southern OB stars of various luminosity class has been secured. Program stars have been selected, among those bright enough in the infrared to give a suitable photometric accuracy, in order to cover a wide range of spectral types. 37 stars are found to exhibit emission in excess over a blackbody photospheric continuum, which is interpreted in terms of gas ejected in the form of an accelerated wind. By means of model calculations the corresponding mass loss rates are derived. The obtained values compare well with those determined independently by various authors for stars in common. Their data show that mass loss rates increase with luminosity and are a decreasing function of surface gravity. (Auth.)

  10. Dropping Probability Reduction in OBS Networks: A Simple Approach

    KAUST Repository

    Elrasad, Amr

    2016-08-01

    In this paper, we propose and derive a slotted-time model for analyzing the burst blocking probability in Optical Burst Switched (OBS) networks. We evaluated the immediate and delayed signaling reservation schemes. The proposed model compares the performance of both just-in-time (JIT) and just-enough-time (JET) signaling protocols associated with of void/non-void filling link scheduling schemes. It also considers none and limited range wavelength conversions scenarios. Our model is distinguished by being adaptable to different offset-time and burst length distributions. We observed that applying a limited range of wavelength conversion, burst blocking probability is reduced by several orders of magnitudes and yields a better burst delivery ratio compared with full wavelength conversion.

  11. Performance analysis of signaling protocols on OBS switches

    Science.gov (United States)

    Kirci, Pinar; Zaim, A. Halim

    2005-10-01

    In this paper, Just-In-Time (JIT), Just-Enough-Time (JET) and Horizon signalling schemes for Optical Burst Switched Networks (OBS) are presented. These signaling schemes run over a core dWDM network and a network architecture based on Optical Burst Switches (OBS) is proposed to support IP, ATM and Burst traffic. In IP and ATM traffic several packets are assembled in a single packet called burst and the burst contention is handled by burst dropping. The burst length distribution in IP traffic is arbitrary between 0 and 1, and is fixed in ATM traffic at 0,5. Burst traffic on the other hand is arbitrary between 1 and 5. The Setup and Setup ack length distributions are arbitrary. We apply the Poisson model with rate λ and Self-Similar model with pareto distribution rate α to identify inter-arrival times in these protocols. We consider a communication between a source client node and a destination client node over an ingress and one or more multiple intermediate switches.We use buffering only in the ingress node. The communication is based on single burst connections in which, the connection is set up just before sending a burst and then closed as soon as the burst is sent. Our analysis accounts for several important parameters, including the burst setup, burst setup ack, keepalive messages and the optical switching protocol. We compare the performance of the three signalling schemes on the network under as burst dropping probability under a range of network scenarios.

  12. Observations of mass loss from OB and Wolf-Rayet stars

    International Nuclear Information System (INIS)

    Barlow, M.J.

    1982-01-01

    In this review, three observationally accessible parameters of the winds of OB and Wolf-Rayet stars are discussed: (1) Terminal velocities, (2) Velocity laws, (3) Mass loss rates. In addition, some discussion of the ionisation structure of the winds is included. In general, only the most recent results for OB stars are mentioned. (Auth.)

  13. COSMIC ORIGINS SPECTROGRAPH OBSERVATIONS OF TRANSLUCENT CLOUDS: Cyg OB2 8A

    International Nuclear Information System (INIS)

    Snow, Theodore P.; Destree, Joshua D.; Burgh, Eric B.; Ferguson, Ryan M.; Danforth, Charles W.; Cordiner, Martin

    2010-01-01

    Data from the Cosmic Origins Spectrograph (COS) are presented for the first highly reddened target (Cyg OB2 8A) under the COS Science Team's guaranteed time allocation. Column densities of ionic, atomic, and molecular species are reported and implications are discussed. Data from Cyg OB2 8A demonstrate the ability to analyze highly reddened interstellar sight lines with the COS that were unavailable to previous UV instruments. Measured column densities indicate that the Cyg OB2 8A line of sight contains multiple diffuse clouds rather than a dominant translucent cloud.

  14. New Parallaxes for the Upper Scorpius OB Association

    Science.gov (United States)

    Donaldson, J. K.; Weinberger, A. J.; Gagné, J.; Boss, A. P.; Keiser, S. A.

    2017-11-01

    Upper Scorpius is a subgroup of the nearest OB association, Scorpius-Centaurus. Its young age makes it an important association to study star and planet formation. We present parallaxes to 52 low-mass stars in Upper Scorpius, 28 of which have full kinematics. We measure ages of the individual stars by combining our measured parallaxes with pre-main-sequence evolutionary tracks. We find a significant difference in the ages of stars with and without circumstellar disks. The stars without disks have a mean age of 4.9 ± 0.8 Myr and those with disks have an older mean age of 8.2 ± 0.9 Myr. This somewhat counterintuitive result suggests that evolutionary effects in young stars can dominate their apparent ages. We also attempt to use the 28 stars with full kinematics (I.e., proper motion, radial velocity (RV), and parallax) to trace the stars back in time to their original birthplace to obtain a trackback age. As expected, given the large measurement uncertainties on available RV measurements, we find that measurement uncertainties alone cause the group to diverge after a few Myr.

  15. Study of clumping in the Cepheus OB 3 molecular cloud

    International Nuclear Information System (INIS)

    Carr, J.S.

    1987-01-01

    A portion of the Cep OB 3 molecular cloud has been mapped in the (C-13)O (1-0) line on a completely sampled grid with a 1.5-arcmin spacing. A total of 45 individual clouds, or clumps, have been identified in the map, with masses from 3 to 300 solar mass, sizes 3 pc or smaller, and mean densities of a few hundred/cu cm. Power-law correlations are found among the clump properties, namely, M proportional to R exp 2.5 and Delta(v) exp 0.24. These exponents differ somewhat from those found for similar correlations for molecular clouds in previous studies. Determination of the virial masses for the clumps shows that the clumps are not gravitationally bound and must be expanding on a time scale of about 1 Myr. Measurements of the (C-13)O (2-1) line give volume densities of 2000-5000. Comparisons of these densities with the mean volume densities from the (C-13)O (1-0) data suggest that the gas is clumped on a small scale with a volume filling factor of 0.04-0.10. 31 references

  16. A Novel Congestion Detection Scheme in TCP Over OBS Networks

    KAUST Repository

    Shihada, Basem

    2009-02-01

    This paper introduces a novel congestion detection scheme for high-bandwidth TCP flows over optical burst switching (OBS) networks, called statistical additive increase multiplicative decrease (SAIMD). SAIMD maintains and analyzes a number of previous round-trip time (RTTs) at the TCP senders in order to identify the confidence with which a packet loss event is due to network congestion. The confidence is derived by positioning short-term RTT in the spectrum of long-term historical RTTs. The derived confidence corresponding to the packet loss is then taken in the developed policy for TCP congestion window adjustment. We will show through extensive simulation that the proposed scheme can effectively solve the false congestion detection problem and significantly outperform the conventional TCP counterparts without losing fairness. The advantages gained in our scheme are at the expense of introducing more overhead in the SAIMD TCP senders. Based on the proposed congestion control algorithm, a throughput model is formulated, and is further verified by simulation results.

  17. Influences of obese (ob/ob and diabetes (db/db genotype mutations on lumber vertebral radiological and morphometric indices: Skeletal deformation associated with dysregulated systemic glucometabolism

    Directory of Open Access Journals (Sweden)

    Garris David R

    2006-02-01

    Full Text Available Abstract Background Both diabetes and obesity syndromes are recognized to promote lumbar vertebral instability, premature osteodegeneration, exacerbate progressive osteoporosis and increase the propensity towards vertebral degeneration, instability and deformation in humans. Methods The influences of single-gene missense mutations, expressing either diabetes (db/db or obese (ob/ob metabolic syndromes on vertebral maturation and development in C57BL/KsJ mice were evaluated by radiological and macro-morphometric analysis of the resulting variances in osteodevelopment indices relative to control parameters between 8 and 16 weeks of age (syndrome onset @ 4 weeks, and the influences of low-dose 17-B-estradiol therapy on vertebral growth expression evaluated. Results Associated with the indicative genotypic obesity and hyper-glycemic/-insulinemic states, both db/db and ob/ob mutants demonstrated a significant (P ≤ 0.05 elongation of total lumbar vertebrae column (VC regional length, and individual lumbar vertebrae (LV1-5 lengths, relative to control VC and LV parameters. In contrast, LV1-5 width indices were suppressed in db/db and ob/ob mutants relative to control LV growth rates. Between 8 and 16 weeks of age, the suppressed LV1-5 width indices were sustained in both genotype mutant groups relative to control osteomaturation rates. The severity of LV1-5 width osteosuppression correlated with the severe systemic hyperglycemic and hypertriglyceridemic conditions sustained in ob/ob and db/db mutants. Low-dose 17-B-estradiol therapy (E2-HRx: 1.0 ug/ 0.1 ml oil s.c/3.5 days, initiated at 4 weeks of age (i.e., initial onset phase of db/db and ob/ob expressions re-established control LV 1–5 width indices without influencing VC or LV lengths in db/db groups. Conclusion These data demonstrate that the abnormal systemic endometabolic states associated with the expression of db/db and ob/ob genomutation syndromes suppress LV 1–5 width osteomaturation

  18. Expression of the P2X2 receptor in different classes of ileum myenteric neurons in the female obese ob/ob mouse

    Science.gov (United States)

    Mizuno, Márcia Sanae; Crisma, Amanda Rabello; Borelli, Primavera; Castelucci, Patricia

    2012-01-01

    AIM: To examine whether the ob/ob mouse model of obesity is accompanied by enteric nervous system abnormalities such as altered motility. METHODS: The study examined the distribution of the P2X2 receptor (P2X2R) in myenteric neurons of female ob/ob mice. Specifically, we used immunohistochemistry to analyze the co-expression of the P2X2R with neuronal nitric oxide synthase (nNOS), choline acetyltransferase (ChAT), and calretinin (CalR) in neurons of the small intestine myenteric plexus in ob/ob and control female mice. In these sections, we used scanning confocal microscopy to analyze the co-localization of these markers as well as the neuronal density (cm2) and area profile (μm²) of P2X2R-positive neurons. In addition, enteric neurons were labeled using the nicotinamide adenine dinucleotide (NADH) diaphorase method and analyzed with light microscopy as an alternate means by which to analyze neuronal density and area. RESULTS: In the present study, we observed a 29.6% increase in the body weight of the ob/ob animals (OG) compared to the control group (CG). In addition, the average small intestine area was increased by approximately 29.6% in the OG compared to the CG. Immunoreactivity (IR) for the P2X2R, nNOS, ChAT and CalR was detectable in the myenteric plexus, as well as in the smooth muscle, in both groups. This IR appeared to be mainly cytoplasmic and was also associated with the cell membrane of the myenteric plexus neurons, where it outlined the neuronal cell bodies and their processes. P2X2R-IR was observed to co-localize 100% with that for nNOS, ChAT and CalR in neurons of both groups. In the ob/ob group, however, we observed that the neuronal density (neuron/cm2) of P2X2R-IR cells was increased by 62% compared to CG, while that of NOS-IR and ChAT-IR neurons was reduced by 49% and 57%, respectively, compared to control mice. The neuronal density of CalR-IR neurons was not different between the groups. Morphometric studies further demonstrated that the

  19. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice.

    Science.gov (United States)

    Huang, S-L; Yu, R-T; Gong, J; Feng, Y; Dai, Y-L; Hu, F; Hu, Y-H; Tao, Y-D; Leng, Y

    2012-05-01

    Arctigenin is a natural compound that had never been previously demonstrated to have a glucose-lowering effect. Here it was found to activate AMP-activated protein kinase (AMPK), and the mechanism by which this occurred, as well as the effects on glucose and lipid metabolism were investigated. 2-Deoxyglucose uptake and AMPK phosphorylation were examined in L6 myotubes and isolated skeletal muscle. Gluconeogenesis and lipid synthesis were evaluated in rat primary hepatocytes. The acute and chronic effects of arctigenin on metabolic abnormalities were observed in C57BL/6J and ob/ob mice. Changes in mitochondrial membrane potential were measured using the J-aggregate-forming dye, JC-1. Analysis of respiration of L6 myotubes or isolated mitochondria was conducted in a channel oxygen system. Arctigenin increased AMPK phosphorylation and stimulated glucose uptake in L6 myotubes and isolated skeletal muscles. In primary hepatocytes, it decreased gluconeogenesis and lipid synthesis. The enhancement of glucose uptake and suppression of hepatic gluconeogenesis and lipid synthesis by arctigenin were prevented by blockade of AMPK activation. The respiration of L6 myotubes or isolated mitochondria was inhibited by arctigenin with a specific effect on respiratory complex I. A single oral dose of arctigenin reduced gluconeogenesis in C57BL/6J mice. Chronic oral administration of arctigenin lowered blood glucose and improved lipid metabolism in ob/ob mice. This study demonstrates a new role for arctigenin as a potent indirect activator of AMPK via inhibition of respiratory complex I, with beneficial effects on metabolic disorders in ob/ob mice. This highlights the potential value of arctigenin as a possible treatment of type 2 diabetes.

  20. [Detection of psychosocial dysfunction in ob-gyn patients].

    Science.gov (United States)

    González-Forteza, C F; Morales Carmona, F; Gutiérrez Calderon, E

    1993-01-01

    The human behavior and its social determinants are critical variables for understanding the etiology, treatment, and prevention of many disorders previously attributed to biological substrates. Among the many categories of human behavior to receive special attention from health researchers and practitioners are life events, coping responses and emotional state. The relation between these categories constituted a particular field of investigation. This relationship rather than forcing to focus on disease, distress, disability, and other failures in human functioning, permits to address health, abilities, resources, and other positive aspects of human functioning. On the other hand, the re-organization of health services considers interdisciplinary work as an objective, as it is necessary to care for the patient in an integral manner, with the consequent benefit of a more efficient service. In addition it is known that patients with psychosocial dysfunctions who use general practice care facilities overutilize these services in an unnecessary manner. With this in mind it is clear that is necessary to balance the service's cost-benefit for a more efficient clinical attention. In this paper we present the results of the categories mentioned above: life events, coping responses and its relationship with emotional state in a representative sample of 399 female patients who in 1986 received services at the National Institute of Perinatology-INPer-. Of these patients, 297 were obstetrical patients -OBS- and 102 gynaecological ones -GINE-. All patients answered these instruments: General Health Questionnaire -GHQ-7 of 30 items, a subscale of Health and Daily Living for Coping Responses and Life Events Scale.(ABSTRACT TRUNCATED AT 250 WORDS)

  1. A CATALOG OF NEW SPECTROSCOPICALLY CONFIRMED MASSIVE OB STARS IN CARINA

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, Michael J.; Hanes, Richard J.; McSwain, M. Virginia [Department of Physics, Lehigh University, 16 Memorial Drive East, Bethlehem, PA 18015 (United States); Povich, Matthew S., E-mail: alexamic@lafayette.edu, E-mail: rjh314@lehigh.edu, E-mail: mcswain@lehigh.edu, E-mail: mspovich@cpp.edu [Department of Physics and Astronomy, California State Polytechnic University, Pomona, CA 91768 (United States)

    2016-12-01

    The Carina star-forming region is one of the largest in the Galaxy, and its massive star population is still being unveiled. The large number of stars combined with high, and highly variable, interstellar extinction makes it inherently difficult to find OB stars in this type of young region. We present the results of a spectroscopic campaign to study the massive star population of the Carina Nebula, with the primary goal to confirm or reject previously identified Carina OB star candidates. A total of 141 known O- and B-type stars and 94 candidates were observed, of which 73 candidates had high enough signal-to-noise ratio to classify. We find 23 new OB stars within the Carina Nebula, a 32% confirmation rate. One of the new OB stars has blended spectra and is suspected to be a double-lined spectroscopic binary (SB2). We also reclassify the spectral types of the known OB stars and discover nine new SB2s among this population. Finally, we discuss the spatial distribution of these new OB stars relative to known structures in the Carina Nebula.

  2. Radionuclides in the Ob/Irtysh river system and their contribution to pollution of the Arctic

    International Nuclear Information System (INIS)

    Trapeznikov, A.; Pozolotina, V.; Trapeznikova, V.; Yushkov, P.; Polikarpov, G.; Aarkrog, A.; Nielsen, S.P.

    1995-01-01

    The aims of this study were: 1) to continue the investigation of distribution of radionuclides in the principal components of the Techa river, and 2) to get the first estimate of the contamination of sediments of the Iset, Tobol, Irtysh and Ob rivers. The samples from the Irtysh river were collected in 1993 nine km in front of confluence of the Irtysh with the Ob river. The mean Cs-137 concentration in the sediments did not show any clear trend. The sediments from the Ob river were collected in 1992 near Labitnangi, situated about 300 km from the outlet of the Ob into the Kara Sea. In 1994 samples were collected five km in front of and five km after confluence with the Irtysh river. All results are summarized in a table. It appears that the Cs-137 levels in the Ob sediments, before and after confluence with Irtysh, do not change significantly. It is difficult to see any systematic changes in Cs-137 concentrations with depth. In some cases the top five cm show higher concentrations than the deeper layers. 7 refs., 1 tab

  3. Search for OB stars running away from young star clusters. I. NGC 6611

    Science.gov (United States)

    Gvaramadze, V. V.; Bomans, D. J.

    2008-11-01

    N-body simulations have shown that the dynamical decay of the young (~1 Myr) Orion Nebula cluster could be responsible for the loss of at least half of its initial content of OB stars. This result suggests that other young stellar systems could also lose a significant fraction of their massive stars at the very beginning of their evolution. To confirm this expectation, we used the Mid-Infrared Galactic Plane Survey (completed by the Midcourse Space Experiment satellite) to search for bow shocks around a number of young (⪉several Myr) clusters and OB associations. We discovered dozens of bow shocks generated by OB stars running away from these stellar systems, supporting the idea of significant dynamical loss of OB stars. In this paper, we report the discovery of three bow shocks produced by O-type stars ejected from the open cluster NGC 6611 (M16). One of the bow shocks is associated with the O9.5Iab star HD165319, which was suggested to be one of “the best examples for isolated Galactic high-mass star formation” (de Wit et al. 2005, A&A, 437, 247). Possible implications of our results for the origin of field OB stars are discussed.

  4. Production of metal and metal-ceramic coatings on D-Gun Ob

    International Nuclear Information System (INIS)

    Gavrilenko, T.P.; Nikolaev, Y.A.; Ulianitsky, V.Y.

    1995-01-01

    Optimization of the detonation spraying process has been made for the production of metal and metal-ceramics coatings with the D-Gun Ob. Owing to the ability of Ob to work with several fuels and an inert diluent simultaneously, variation of detonation regimes in a wide range is possible, and because of localized powder injection in the D-Gun barrel, high uniformity of parameters of powder particles is achieved. The best conditions for particle heating and acceleration were calculated with the help of mathematical simulation, and the corresponding regimes were realized on D-Gun Ob. High-quality aluminum, copper, nickel, and nickel-chromium-silicon-carbon-boron alloy coatings were produced by using only propane fuel. Chromium carbide with nickel and tungsten carbide with cobalt coatings were produced with addition of acetylene. Optimal efficiency and high bonding strength were achieved for all powders. Data on microhardness, bonding strength, and efficiency are presented

  5. The performance study of oxide by-passed(OB) lateral double diffused MOSFET

    Science.gov (United States)

    Tang, Pan-pan

    2016-10-01

    An SOI LDMOS device structure with Oxide By-passed(OB) was investigated and its breakdown mechanism and characteristic of structure was analyzed. Its performance was verified by 3D numerical simulation with SILVACO TCAD software. The simulated results show that the electrical field element of the device is modulated by the concept of similar Superjunction(SJ) structure. Compared with the SJ LDMOS device, OB LDMOS obtains the same breakdown voltage, simultaneously the specific on-resistance of the OB LDMOS reduces from 3.81mΩ·cm2 to 1.96mΩ·cm2, except for achieving comparable performance and overcoming the high aspect ratio of fabrication structure and the difficulty of accurate concentration match of SJ LDMOS.

  6. ESTIMATION OF BURSTS LENGTH AND DESIGN OF A FIBER DELAY LINE BASED OBS ROUTER

    Directory of Open Access Journals (Sweden)

    RICHA AWASTHI

    2017-03-01

    Full Text Available The demand for higher bandwidth is increasing day by day and this ever growing demand cannot be catered to with current electronic technology. Thus new communication technology like optical communication needs to be used. In the similar context OBS (optical burst switching is considered as next generation data transfer technology. In OBS information is transmitted in forms of optical bursts of variable lengths. However, contention among the bursts is a major problem in OBS system, and for contention resolution defection routing is mostly preferred. However, deflection routing increases delay. In this paper, it is shown that the arrival of very large bursts is rare event, and for moderate burst length the buffering of contending burst can provide very effective solution. However, in case of arrival of large bursts deflection can be used.

  7. The OB run-away stars from Sco-Cen and Orion reviewed

    International Nuclear Information System (INIS)

    Blaauw, A.

    1989-01-01

    The author studies the past paths of the run-away star Zeta Oph from the OB association Sco-Cen, and of the run-away stars AE Aur, Mu Col and 53 Ari from the OB association Ori OB1, in connection with the question of the origin of these high velocities. Should the binary-hypothesis be adhered to (supernova explosion of one of the components) or, perhaps, dynamical evolution in young, dense clusters offer a clue to this phenomenon? It is shown that the latter hypothesis is very unlikely to apply to Zeta Oph. For the run-away stars from Orion conclusive evidence may well be obtained in the course of the next decade, from improved accuracy of the proper motions

  8. Transcriptional activation of the mouse obese (ob) gene by CCAAT/enhancer binding protein alpha

    DEFF Research Database (Denmark)

    Hwang, C S; Mandrup, S; MacDougald, O A

    1996-01-01

    Like other adipocyte genes that are transcriptionally activated by CCAAT/enhancer binding protein alpha (C/EBP alpha) during preadipocyte differentiation, expression of the mouse obese (ob) gene is immediately preceded by the expression of C/EBP alpha. While the 5' flanking region of the mouse ob...... gene contains several consensus C/EBP binding sites, only one of these sites appears to be functional. DNase I cleavage inhibition patterns (footprinting) of the ob gene promoter revealed that recombinant C/EBP alpha, as well as a nuclear factor present in fully differentiated 3T3-L1 adipocytes...... to a consensus C/EBP binding site at nucleotides -55 to -47 generated a specific protein-oligonucleotide complex that was supershifted by antibody against C/EBP alpha. Probes corresponding to two upstream consensus C/EBP binding sites failed to generate protein-oligonucleotide complexes. Cotransfection of a C...

  9. NEAR INFRARED DIFFUSE INTERSTELLAR BANDS TOWARD THE CYGNUS OB2 ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Hamano, Satoshi; Kondo, Sohei; Sameshima, Hiroaki; Nakanishi, Kenshi; Kawakita, Hideyo [Laboratory of Infrared High-resolution Spectroscopy, Koyama Astronomical Observatory, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555 (Japan); Kobayashi, Naoto [Institute of Astronomy, School of Science, University of Tokyo, 2-21-1 Osawa, Mitaka, Tokyo 181-0015 (Japan); Ikeda, Yuji [Photocoding, 460-102 Iwakura-Nakamachi, Sakyo-ku, Kyoto, 606-0025 (Japan); Yasui, Chikako; Mizumoto, Misaki; Matsunaga, Noriyuki; Fukue, Kei; Yamamoto, Ryo; Izumi, Natsuko [Department of Astronomy, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Mito, Hiroyuki [Kiso Observatory, Institute of Astronomy, School of Science, The University of Tokyo, 10762-30 Mitake, Kiso-machi, Kiso-gun, Nagano, 397-0101 (Japan); Nakaoka, Tetsuya; Kawanishi, Takafumi; Kitano, Ayaka; Otsubo, Shogo [Department of Physics, Faculty of Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555 (Japan); Kinoshita, Masaomi, E-mail: hamano@cc.kyoto-su.ac.jp [Solar-Terrestrial Environment Laboratory, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8601 (Japan)

    2016-04-10

    We obtained the near-infrared (NIR) high-resolution (R ≡ λ/Δλ ∼ 20,000) spectra of the seven brightest early-type stars in the Cygnus OB2 association for investigating the environmental dependence of diffuse interstellar bands (DIBs). The WINERED spectrograph mounted on the Araki 1.3 m telescope in Japan was used to collect data. All 20 of the known DIBs within the wavelength coverage of WINERED (0.91 < λ < 1.36 μm) were clearly detected along all lines of sight because of their high flux density in the NIR wavelength range and the large extinction. The equivalent widths (EWs) of DIBs were not correlated with the column densities of C{sub 2} molecules, which trace the patchy dense component, suggesting that the NIR DIB carriers are distributed mainly in the diffuse component. On the basis of the correlations among the NIR DIBs both for stars in Cyg OB2 and stars observed previously, λλ10780, 10792, 11797, 12623, and 13175 are found to constitute a “family,” in which the DIBs are correlated well over the wide EW range. In contrast, the EW of λ10504 is found to remain almost constant over the stars in Cyg OB2. The extinction estimated from the average EW of λ10504 (A{sub V} ∼ 3.6 mag) roughly corresponds to the lower limit of the extinction distribution of OB stars in Cyg OB2. This suggests that λ10504 is absorbed only by the foreground clouds, implying that the carrier of λ10504 is completely destroyed in Cyg OB2, probably by the strong UV radiation field. The different behaviors of the DIBs may be caused by different properties of the DIB carriers.

  10. Magnetic field of massive chemically peculiar stars in the Orion OB1 association

    Science.gov (United States)

    Romanyuk, I. I.; Semenko, E. A.; Kudryavtsev, D. O.; Yakunin, I. A.

    2018-01-01

    Spectropolarimetric observations of 55 chemically peculiar stars in the Orion OB1 association were obtained at the 6 m telescope of the Russian Academy of Sciences with the aim of searching for the presence of stellar magnetic fields. We found 8 new magnetic stars in addition to 20 previously known objects. The frequency of chemically peculiar A and B-type stars among normal A and B-type stars and the frequency of magnetic stars among all chemically peculiar stars decreases with age in the Orion OB1 association.

  11. Analyzing the Effects of Nitrogen Deficiency on the PHB Production of Methylosinus trichosporium OB3b

    Science.gov (United States)

    Kyauk, E.

    2011-12-01

    Polyhydroxybutyrate (PHB) is a biodegradable thermoplastic that is produced by various microorganisms. Because of its potential to replace conventional plastics, it has been closely researched in the past few years. Methanotrophic bacteria, bacteria that consume methane, produce this bioplastic when it lacks certain nutrients. The utilization of methane to produce PHB shows much promise as methane is a cheap, plentiful gas. In this study, we observed the methanotroph, Methylosinus trichosporium OB3b , and its yield of PHB in the absence of nitrogen. The optical density of Methylosinus trichosporium OB3b was measured in order to observe cell growth and PHB production patterns over a 48 hour period.

  12. Advective transport observations with MODPATH-OBS--documentation of the MODPATH observation process

    Science.gov (United States)

    Hanson, R.T.; Kauffman, L.K.; Hill, M.C.; Dickinson, J.E.; Mehl, S.W.

    2013-01-01

    The MODPATH-OBS computer program described in this report is designed to calculate simulated equivalents for observations related to advective groundwater transport that can be represented in a quantitative way by using simulated particle-tracking data. The simulated equivalents supported by MODPATH-OBS are (1) distance from a source location at a defined time, or proximity to an observed location; (2) time of travel from an initial location to defined locations, areas, or volumes of the simulated system; (3) concentrations used to simulate groundwater age; and (4) percentages of water derived from contributing source areas. Although particle tracking only simulates the advective component of conservative transport, effects of non-conservative processes such as retardation can be approximated through manipulation of the effective-porosity value used to calculate velocity based on the properties of selected conservative tracers. This program can also account for simple decay or production, but it cannot account for diffusion. Dispersion can be represented through direct simulation of subsurface heterogeneity and the use of many particles. MODPATH-OBS acts as a postprocessor to MODPATH, so that the sequence of model runs generally required is MODFLOW, MODPATH, and MODPATH-OBS. The version of MODFLOW and MODPATH that support the version of MODPATH-OBS presented in this report are MODFLOW-2005 or MODFLOW-LGR, and MODPATH-LGR. MODFLOW-LGR is derived from MODFLOW-2005, MODPATH 5, and MODPATH 6 and supports local grid refinement. MODPATH-LGR is derived from MODPATH 5. It supports the forward and backward tracking of particles through locally refined grids and provides the output needed for MODPATH_OBS. For a single grid and no observations, MODPATH-LGR results are equivalent to MODPATH 5. MODPATH-LGR and MODPATH-OBS simulations can use nearly all of the capabilities of MODFLOW-2005 and MODFLOW-LGR; for example, simulations may be steady-state, transient, or a combination

  13. [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, small molecule synthetic peptide leptin mimetics, improve glycemic control in diet-induced obese (DIO) mice.

    Science.gov (United States)

    Wang, Anke; Anderson, Brian M; Novakovic, Zachary M; Grasso, Patricia

    2018-03-01

    We have previously shown that following oral delivery in dodecyl maltoside (DDM), [D-Leu-4]-OB3 and its myristic acid conjugate, MA-[D-Leu-4]-OB3, improved energy balance and glucose homeostasis in genetically obese/diabetic mouse models. More recently, we have provided immunohistochemical evidence indicating that these synthetic peptide leptin mimetics cross the blood-brain barrier and concentrate in the area of the arcuate nucleus of the hypothalamus in normal C57BL/6J and Swiss Webster mice, in genetically obese ob/ob mice, and in diet-induced obese (DIO) mice. In the present study, we describe the effects of oral delivery of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 on glycemic control in diet-induced (DIO) mice, a non-genetic rodent model of obesity and its associated insulin resistance, which more closely recapitulates common obesity and diabetes in humans. Male C57BL/6J and DIO mice, 17, 20, and 28 weeks of age, were maintained on a low-fat or high-fat diet and given vehicle (DDM) alone or [D-Leu-4]-OB3 or MA-[D-Leu-4]-OB3 in DDM by oral gavage for 12 or 14 days. Body weight gain, food and water intake, fasting blood glucose, oral glucose tolerance, and serum insulin levels were measured. Our data indicate that (1) [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 restore glucose tolerance in male DIO mice maintained on a high-fat diet to levels comparable to those of non-obese C57BL/6J wild-type mice of the same age and sex maintained on a low-fat diet; and (2) the influence of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 on glycemic control appears to be independent of their effects on energy balance. These results suggest that [D-Leu-4]-OB3 and/or MA-[D-Leu-4]-OB3 may have application to the management of the majority of cases of common obesity in humans, a state characterized at least in part, by leptin resistance resulting from a defect in leptin transport across the blood-brain barrier. They further suggest that these small molecule synthetic peptide leptin mimetics, through their

  14. Conversion of chlorinated propanes by Methylosinus trichosporium OB3b expressing soluble methane monooxygenase

    NARCIS (Netherlands)

    Bosma, T.; Janssen, D.B.

    Chlorinated propanes are important pollutants that may show persistent behaviour in the environment. The biotransformation of 1-chloropropane, 1,2-dichloropropane, 1,3-dichloropropane and 1,2,3-trichloropropane was studied using resting cell suspensions of Methylosinus trichosporium OB3b expressing

  15. Formation of massive stars in OB associations and giant molecular clouds

    International Nuclear Information System (INIS)

    Lada, C.J.

    1980-01-01

    Certain interesting patterns are being perceived in the morphology of the regions which have recently produced massive OB stars. In particular, current evidence seems to favour the notion that the formation of massive stars takes place at the edges and not the centres of large molecular cloud complexes. It is this aspect of the observations that is discussed in the present paper. The phenomena described here will pertain to massive stars only. Specifically, stars with spectral types earlier than B3 will be considered since it is usually only these stars that produce sufficient havoc (e.g., maser sources, CO bright spots, H II regions) to noticeably affect their early environments. The corresponding phenomena for lower mass stars could be entirely different. A review is first presented of what has been learned about the OB star formation process from studies of the visible OB stars themselves. Then, newly derived information pertaining to the most recent episodes of OB star birth in galactic molecular clouds is discussed. Finally, a short discussion of the significance of the results and their implications for possible star formation mechanisms will be made. (U.K.)

  16. Degradation of Chlorinated Aliphatic Hydrocarbons by Methylosinus trichosporium OB3b Expressing Soluble Methane Monooxygenase

    NARCIS (Netherlands)

    Oldenhuis, R.; Vink, Ruud L.J.M.; Janssen, D. B.; Witholt, B.

    1989-01-01

    Degradation of trichloroethylene (TCE) by the methanotrophic bacterium Methylosinus trichosporium OB3b was studied by using cells grown in continuous culture. TCE degradation was a strictly cometabolic process, requiring the presence of a cosubstrate, preferably formate, and oxygen. M. trichosporium

  17. Inter-Division IV/V WG on Active OB Stars

    NARCIS (Netherlands)

    Owocki, S.; Aerts, C.; Fabregat, J.; Gies, D.; Henrichs, H.F.; McDavid, D.; Porter, J.; Rivinius, T.; Peters, G.; Stefl, S.

    2007-01-01

    Our group studies active early-type (OB) stars, with historical focus on classical Be stars, but extending in recent years to include Slowly Pulsating B-stars (SPB), Beta-Cephei stars, the strongly magnetic Bp stars, Luminous Blue Vairiable (LBV) stars, and B[e] stars. An overall goal is to

  18. Kinetics of Chlorinated Hydrocarbon Degradation by Methylosinus trichosporium OB3b and Toxicity of Trichloroethylene

    NARCIS (Netherlands)

    Oldenhuis, Roelof; Oedzes, Johannes Y.; Waarde, Jacob J. van der; Janssen, Dick B.

    The kinetics of the degradation of trichloroethylene (TCE) and seven other chlorinated aliphatic hydrocarbons by Methylosinus trichosporium OB3b were studied. All experiments were performed with cells grown under copper stress and thus expressing soluble methane monooxygenase. Compounds that were

  19. VizieR Online Data Catalog: Velocity and proper motion of OB associations (Melnik+, 2009)

    Science.gov (United States)

    Melnik, A. M.; Dambis, A. K.

    2009-11-01

    For every OB-association from the list by Blaha and Humphreys (1989AJ.....98.1598B) we give the mean galactic coordinates l and b, the mean heliocentric distance r, median line-of-sight velocity Vr, the dispersion of line-of-sight velocities dvr, and number of stars with known line-of-sight velocity nvr. The line-of-sight velocities were taken from the catalog by Barbier-Brossat and Figon (1999, Cat. ). We used only the velocities measured with errors of less than 10km/s which corresponds to the quality estimations A, B, and C. We also present median proper motions of OB-associations along l- and b- coordinates, mul and mub. The data obtained for the old reduction (1997, Cat. ) are denoted by the subscript 1, whereas those based on the reduction by van Leewen (2008, Cat. ) are marked by the subscript 2. For each OB association we represent the dispersions of proper motions, dml and dmb, as well as a number of stars nmu with known proper motion. The last column shows the total number of stars with known photometric measurements, Nt, used for determination of the distances for OB-associations. The distances r correspond to the short distance scale for classical Cepheids. They are equal to the distances from the catalog by Blaha and Humphreys (1989AJ.....98.1598B), rBH, multiplied by a factor of 0.8, r=0.8*rBH. (1 data file).

  20. High rate of vaginal erosions associated with the mentor ObTape.

    Science.gov (United States)

    Yamada, Brian S; Govier, Fred E; Stefanovic, Ksenija B; Kobashi, Kathleen C

    2006-08-01

    The transobturator tape method is a newer surgical technique for the treatment of stress urinary incontinence. Limited data exist related to complications with this approach or the types of mesh products used. We report our experience with vaginal erosions associated with the Mentor ObTape and American Medical Systems Monarc transobturator slings. Beginning in December 2003 selected female patients with anatomic urinary incontinence were prospectively followed after placement of the Mentor ObTape. Beginning in January 2004 we also began using the American Medical Systems Monarc in similar patients. Patients were admitted overnight after surgery, discharged on oral antibiotics, and seen in the clinic at 6 weeks postoperatively. A total of 67 patients have undergone placement of the Mentor ObTape and 9 of those patients (13.4%) have had vaginal extrusions of the sling. Eight patients reported a history of persistent vaginal discharge. One patient presented initially to an outside facility with a left thigh abscess tracking to the left inguinal incision site. Each patient was taken back to the operating room for mesh removal. A total of 56 patients have undergone placement of the AMS Monarc and none have had any vaginal erosions. Our high rate of vaginal extrusion using the ObTape has led us to discontinue the use of this product in our institution. Continued followup of all of these patients will be of critical importance.

  1. ObsPack: a framework for the preparation, delivery, and attribution of atmospheric greenhouse gas data

    NARCIS (Netherlands)

    Masarie, K. A.; Peters, W.; Jacobson, A. R.; Tans, P. P.

    2014-01-01

    Observation Package (ObsPack) is a framework designed to bring together atmospheric greenhouse gas observations from a variety of sampling platforms, prepare them with specific applications in mind, and package and distribute them in a self-consistent and well-documented product. Data products

  2. ObsPack: a framework for the preparation, delivery, and attribution of atmospheric greenhouse gas measurements

    NARCIS (Netherlands)

    Masarie, K. A.; Peters, W.; Jacobson, A. R.; Tans, P. P.

    2014-01-01

    Observation Package (ObsPack) is a framework designed to bring together atmospheric greenhouse gas observations from a variety of sampling platforms, prepare them with specific applications in mind, and package and distribute them in a self-consistent and well-documented product. Data products

  3. Effect of chlorinated ethene conversion on viability and activity of Methylosinus trichosporium OB3b

    NARCIS (Netherlands)

    van Hylckama Vlieg, Johan E.T.; Koning, Wim de; Janssen, Dick B.

    1997-01-01

    The effect of transformation of chlorinated ethenes on the cell viability of Methylosinus trichosporium OB3b was investigated. A comparison of the loss of viability with the decrease in transformation rates shelved that for the monooxygenase-mediated transformation of all chlorinated ethenes except

  4. Analytical model of a burst assembly algorithm for the VBR in the OBS networks

    International Nuclear Information System (INIS)

    Shargabi, M.A.A.; Mellah, H.; Abid, A.

    2008-01-01

    This paper presents a proposed analytical model for the number of bursts aggregated in a period of time in OBS networks. The model considers the case of VBR traffic with two different sending rates, which are SCR and PCR. The model is validated using extensive simulations. Where results from simulations are in total agreement with the results obtained by the proposed model. (author)

  5. Mass loss from OB supergiants in x-ray binary systems

    International Nuclear Information System (INIS)

    Alme, M.L.; Wilson, J.R.

    1975-01-01

    A study of the atmospheres of OB supergiants in x-ray binary systems indicates that when the stellar surface is close enough to the saddle in the gravitational potential to provide a mass transfer rate adequate to power a compact x-ray source, large-amplitude variations in the rate of mass flow occur. 9 references

  6. BOREAS TF-3 NSA-OBS Tower Flux, Meteorological, and Soil Temperature Data

    Science.gov (United States)

    Wofsy, Steven; Sutton, Doug; Goulden, Mike; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-3) team collected tower flux, surface meteorological, and soil temperature data at the BOREAS Northern Study Area-Old Black Spruce (NSA-OBS) site continuously from the March 1994 through October 1996. The data are available in tabular ASCII files.

  7. The Overt Behaviour Scale-Self-Report (OBS-SR) for acquired brain injury: exploratory analysis of reliability and validity.

    Science.gov (United States)

    Kelly, Glenn; Simpson, Grahame K; Brown, Suzanne; Kremer, Peter; Gillett, Lauren

    2017-05-23

    The objectives were to test the properties, via a psychometric study, of the Overt Behaviour Scale-Self-Report (OBS-SR), a version of the OBS-Adult Scale developed to provide a client perspective on challenging behaviours after acquired brain injury. Study sample 1 consisted of 37 patients with primary brain tumour (PBT) and a family-member informant. Sample 2 consisted of 34 clients with other acquired brain injury (mixed brain injury, MBI) and a service-provider informant. Participants completed the OBS-SR (at two time points), and the Awareness Questionnaire (AQ) and Mayo Portland Adaptability Inventory-III (MPAI-III) once; informants completed the OBS-Adult and AQ once only. PBT-informant dyads displayed "good" levels of agreement (ICC 2,k  = .74; OBS-SR global index). Although MBI-informant dyads displayed no agreement (ICC 2,k  = .22; OBS-SR global index), the sub-group (17/29) rated by clinicians as having moderate to good levels of awareness displayed "fair" agreement (ICC 2,k  = .58; OBS-SR global index). Convergent/divergent validity was demonstrated by significant correlations between OBS-SR subscales and MPAI-III subscales with behavioural content (coefficients in the range .36 -.61). Scores had good reliability across one week (ICC 2,k  = .69). The OBS-SR took approximately 15 minutes to complete. It was concluded that the OBS-SR demonstrated acceptable reliability and validity, providing a useful resource in understanding clients' perspectives about their behaviour.

  8. ObsPy: A Python toolbox for seismology - Sustainability, New Features, and Applications

    Science.gov (United States)

    Krischer, L.; Megies, T.; Sales de Andrade, E.; Barsch, R.; MacCarthy, J.

    2016-12-01

    ObsPy (https://www.obspy.org) is a community-driven, open-source project dedicated to offer a bridge for seismology into the scientific Python ecosystem. Amongst other things, it provides Read and write support for essentially every commonly used data format in seismology with a unified interface. This includes waveform data as well as station and event meta information. A signal processing toolbox tuned to the specific needs of seismologists. Integrated access to the largest data centers, web services, and databases. Wrappers around third party codes like libmseed and evalresp. Using ObsPy enables users to take advantage of the vast scientific ecosystem that has developed around Python. In contrast to many other programming languages and tools, Python is simple enough to enable an exploratory and interactive coding style desired by many scientists. At the same time it is a full-fledged programming language usable by software engineers to build complex and large programs. This combination makes it very suitable for use in seismology where research code often must be translated to stable and production ready environments, especially in the age of big data. ObsPy has seen constant development for more than six years and enjoys a large rate of adoption in the seismological community with thousands of users. Successful applications include time-dependent and rotational seismology, big data processing, event relocations, and synthetic studies about attenuation kernels and full-waveform inversions to name a few examples. Additionally it sparked the development of several more specialized packages slowly building a modern seismological ecosystem around it. We will present a short overview of the capabilities of ObsPy and point out several representative use cases and more specialized software built around ObsPy. Additionally we will discuss new and upcoming features, as well as the sustainability of open-source scientific software.

  9. Structure-function analysis of the OB and latch domains of chlorella virus DNA ligase.

    Science.gov (United States)

    Samai, Poulami; Shuman, Stewart

    2011-06-24

    Chlorella virus DNA ligase (ChVLig) is a minimized eukaryal ATP-dependent DNA sealing enzyme with an intrinsic nick-sensing function. ChVLig consists of three structural domains, nucleotidyltransferase (NTase), OB-fold, and latch, that envelop the nicked DNA as a C-shaped protein clamp. The OB domain engages the DNA minor groove on the face of the duplex behind the nick, and it makes contacts to amino acids in the NTase domain surrounding the ligase active site. The latch module occupies the DNA major groove flanking the nick. Residues at the tip of the latch contact the NTase domain to close the ligase clamp. Here we performed a structure-guided mutational analysis of the OB and latch domains. Alanine scanning defined seven individual amino acids as essential in vivo (Lys-274, Arg-285, Phe-286, and Val-288 in the OB domain; Asn-214, Phe-215, and Tyr-217 in the latch), after which structure-activity relations were clarified by conservative substitutions. Biochemical tests of the composite nick sealing reaction and of each of the three chemical steps of the ligation pathway highlighted the importance of Arg-285 and Phe-286 in the catalysis of the DNA adenylylation and phosphodiester synthesis reactions. Phe-286 interacts with the nick 5'-phosphate nucleotide and the 3'-OH base pair and distorts the DNA helical conformation at the nick. Arg-285 is a key component of the OB-NTase interface, where it forms a salt bridge to the essential Asp-29 side chain, which is imputed to coordinate divalent metal catalysts during the nick sealing steps.

  10. Structure-Function Analysis of the OB and Latch Domains of Chlorella Virus DNA Ligase*

    Science.gov (United States)

    Samai, Poulami; Shuman, Stewart

    2011-01-01

    Chlorella virus DNA ligase (ChVLig) is a minimized eukaryal ATP-dependent DNA sealing enzyme with an intrinsic nick-sensing function. ChVLig consists of three structural domains, nucleotidyltransferase (NTase), OB-fold, and latch, that envelop the nicked DNA as a C-shaped protein clamp. The OB domain engages the DNA minor groove on the face of the duplex behind the nick, and it makes contacts to amino acids in the NTase domain surrounding the ligase active site. The latch module occupies the DNA major groove flanking the nick. Residues at the tip of the latch contact the NTase domain to close the ligase clamp. Here we performed a structure-guided mutational analysis of the OB and latch domains. Alanine scanning defined seven individual amino acids as essential in vivo (Lys-274, Arg-285, Phe-286, and Val-288 in the OB domain; Asn-214, Phe-215, and Tyr-217 in the latch), after which structure-activity relations were clarified by conservative substitutions. Biochemical tests of the composite nick sealing reaction and of each of the three chemical steps of the ligation pathway highlighted the importance of Arg-285 and Phe-286 in the catalysis of the DNA adenylylation and phosphodiester synthesis reactions. Phe-286 interacts with the nick 5′-phosphate nucleotide and the 3′-OH base pair and distorts the DNA helical conformation at the nick. Arg-285 is a key component of the OB-NTase interface, where it forms a salt bridge to the essential Asp-29 side chain, which is imputed to coordinate divalent metal catalysts during the nick sealing steps. PMID:21527793

  11. Photoionization of the diffuse interstellar medium and galactic halo by OB associtations

    Science.gov (United States)

    Dove, James B.; Shull, J. Michael

    1994-01-01

    Assuming smoothly varying H I distributions in te Galactic disk, we have calculated the geometry of diffuse II regions due to OB associations in the Galactic plane. Near the solar circle, OB associations with a Lyman continuum (Lyc) photon luminosity Psi(sub Lyc) = 3.3 x 10(exp 7) cm(exp -2) s(exp -1), produce H II regions that are density bounded in the vertical direction (H II chimneys) allowing Lyc to escape the gaseous disk and penetrate into the Galactic halo. We provide analytic formulae for the Lyc escape fraction as functions of S(sub 0) O-star catalog of Garmany and a new Lyc stellar stellar Lyc stellar flux calibration, we find a production rate of Lyc photons by OB associations within 2.5 kpc of Psi(sub Lyc) = 3.3 x 10(exp 7) cm(exp -2) s(exp -1). Integrating the fraction of Lyc photons that escape the disk over our adopted luminosity function of OB associations, we estimate that approximately 7% of the ionizing photons, or Phi(sub Lyc) = 2.3 x 10(exp 6) cm(exp -2) s(exp -1), escape each side of the H I disk layer and penetrate the diffuse ionized medium ('Reynolds layer'). This flux is sufficient to explain the potoionization of this, although we have not constructed a model for the observed H-alpha emission and pulsar dispersion measures that is fully consistent with the absorption rate of Lyc in the H II layer. Since our quiescent model does not account for the effects of dynamic chimneys and superbubbles, which should enhance Lyc escape, we conclude the O stars are the probable source of ionizing radiation for the Reynolds layer. For a random distribution of OB associations throughout the disk, the Lyc flux is nearly uniform for heights Z is greater than approximately 0.8 kpc above the midplane.

  12. Association of plutonium with sediments from the Ob and Yenisey Rivers and Estuaries

    International Nuclear Information System (INIS)

    Skipperud, Lindis; Brown, Justin; Fifield, L. Keith; Oughton, Deborah H.; Salbu, Brit

    2009-01-01

    The present study applied sequential extraction techniques to investigate the binding and mobility of plutonium (Pu) in sediments from the rivers and estuaries of the Ob and Yenisey. As a study site, the Ob and Yenisey are particularly interesting as both rivers have weapons-grade Pu sources in their catchment areas, including the Russian Pu production and reprocessing plants at Mayak, Tomsk-7 and Krashnoyarsk, and the Semipalantinsk nuclear weapons testing site in Kazakhstan. Plutonium activity and 240 Pu/ 239 Pu ratios were determined using accelerator mass spectrometry (AMS). Sequential extractions showed that between 47 and 80% of the Pu in Yenisey River sediments and 35-53% of the Pu in soils around the Techa River are mobilized with weak oxidising agents, which can indicate that Pu is bound to organic material. In contrast, Pu in Ob and Yenisey Estuarine sediments was more strongly bound, with 60-100% being found in the HNO 3 -extractable fraction. This change in speciation could reflect either that Pu bound to organic material in the Techa and Yenisey River sediments becomes more fixed to the sediments with time, or that organic-bound Pu is mobilized and released to the water when the sediments encounter the more saline water of the Ob and Yenisey estuaries. In general, 240 Pu/ 239 Pu ratios were relatively consistent between different extraction fractions, although, in whole sediments, an increase in ratio was observed with distance from the source. This reflects the increased influence of weapon fallout from catchment runoff within the river systems, as compared to the weapons-grade sources close to the production and reprocessing plants. Knowledge of Pu speciation in the Ob and Yenisey Rivers, and the processes controlling its behaviour in estuarine systems, can improve predictions of its transfer and subsequent environmental impact to Arctic Seas

  13. ObsPy: A Python Toolbox for Seismology - Recent Developments and Applications

    Science.gov (United States)

    Megies, T.; Krischer, L.; Barsch, R.; Sales de Andrade, E.; Beyreuther, M.

    2014-12-01

    ObsPy (http://www.obspy.org) is a community-driven, open-source project dedicated to building a bridge for seismology into the scientific Python ecosystem. It offersa) read and write support for essentially all commonly used waveform, station, and event metadata file formats with a unified interface,b) a comprehensive signal processing toolbox tuned to the needs of seismologists,c) integrated access to all large data centers, web services and databases, andd) convenient wrappers to legacy codes like libtau and evalresp.Python, currently the most popular language for teaching introductory computer science courses at top-ranked U.S. departments, is a full-blown programming language with the flexibility of an interactive scripting language. Its extensive standard library and large variety of freely available high quality scientific modules cover most needs in developing scientific processing workflows. Together with packages like NumPy, SciPy, Matplotlib, IPython, Pandas, lxml, and PyQt, ObsPy enables the construction of complete workflows in Python. These vary from reading locally stored data or requesting data from one or more different data centers through to signal analysis and data processing and on to visualizations in GUI and web applications, output of modified/derived data and the creation of publication-quality figures.ObsPy enjoys a large world-wide rate of adoption in the community. Applications successfully using it include time-dependent and rotational seismology, big data processing, event relocations, and synthetic studies about attenuation kernels and full-waveform inversions to name a few examples. All functionality is extensively documented and the ObsPy tutorial and gallery give a good impression of the wide range of possible use cases.We will present the basic features of ObsPy, new developments and applications, and a roadmap for the near future and discuss the sustainability of our open-source development model.

  14. OBS Data Denoising Based on Compressed Sensing Using Fast Discrete Curvelet Transform

    Science.gov (United States)

    Nan, F.; Xu, Y.

    2017-12-01

    OBS (Ocean Bottom Seismometer) data denoising is an important step of OBS data processing and inversion. It is necessary to get clearer seismic phases for further velocity structure analysis. Traditional methods for OBS data denoising include band-pass filter, Wiener filter and deconvolution etc. (Liu, 2015). Most of these filtering methods are based on Fourier Transform (FT). Recently, the multi-scale transform methods such as wavelet transform (WT) and Curvelet transform (CvT) are widely used for data denoising in various applications. The FT, WT and CvT could represent signal sparsely and separate noise in transform domain. They could be used in different cases. Compared with Curvelet transform, the FT has Gibbs phenomenon and it cannot handle points discontinuities well. WT is well localized and multi scale, but it has poor orientation selectivity and could not handle curves discontinuities well. CvT is a multiscale directional transform that could represent curves with only a small number of coefficients. It provide an optimal sparse representation of objects with singularities along smooth curves, which is suitable for seismic data processing. As we know, different seismic phases in OBS data are showed as discontinuous curves in time domain. Hence, we promote to analysis the OBS data via CvT and separate the noise in CvT domain. In this paper, our sparsity-promoting inversion approach is restrained by L1 condition and we solve this L1 problem by using modified iteration thresholding. Results show that the proposed method could suppress the noise well and give sparse results in Curvelet domain. Figure 1 compares the Curvelet denoising method with Wavelet method on the same iterations and threshold through synthetic example. a)Original data. b) Add-noise data. c) Denoised data using CvT. d) Denoised data using WT. The CvT can well eliminate the noise and has better result than WT. Further we applied the CvT denoise method for the OBS data processing. Figure 2a

  15. Deposition of plutonium isotopes and Cs-137 in sediments of the Ob delta from the beginning of the nuclear age

    International Nuclear Information System (INIS)

    Panteleyev, G.P.; Livingston, H.D.; Sayles, F.L.; Medkova, O.N.

    1995-01-01

    As an approach to an assessment of the transport of artificial radionuclides through the Ob river system towards the arctic Ocean, results are presented from the analyses of a series of sediment cores collected in the Ob delta and estuary in 1994. These cores, collected in areas of sediment accumulation, contain the depositional history at the Ob mouth of substances associated with sediment particles from the whole river system watershed. Several approaches to dating these sediments permitted the development of a chronology for the deposition of plutonium isotopes and Cs-137, following their first introduction to the environment a half century ago. Some preliminary results for I-129 are also presented. 6 figs

  16. Multifunctional Bi2ZnOB2O6 single crystals for second and third order nonlinear optical applications

    International Nuclear Information System (INIS)

    Iliopoulos, K.; Kasprowicz, D.; Majchrowski, A.; Michalski, E.; Gindre, D.; Sahraoui, B.

    2013-01-01

    Bi 2 ZnOB 2 O 6 nonlinear optical single crystals were grown by means of the Kyropoulos method from stoichiometric melt. The second and third harmonic generation (SHG/THG) of Bi 2 ZnOB 2 O 6 crystals were investigated by the SHG/THG Maker fringes technique. Moreover, SHG microscopy studies were carried out providing two-dimensional SHG images as a function of the incident laser polarization. The high nonlinear optical efficiency combined with the possibility to grow high quality crystals make Bi 2 ZnOB 2 O 6 an excellent candidate for photonic applications

  17. Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.

    Science.gov (United States)

    Kozuka, Chisayo; Shimizu-Okabe, Chigusa; Takayama, Chitoshi; Nakano, Kaku; Morinaga, Hidetaka; Kinjo, Ayano; Fukuda, Kotaro; Kamei, Asuka; Yasuoka, Akihito; Kondo, Takashi; Abe, Keiko; Egashira, Kensuke; Masuzaki, Hiroaki

    2017-11-01

    Our previous works demonstrated that brown rice-specific bioactive substance, γ-oryzanol acts as a chaperone, attenuates exaggerated endoplasmic reticulum (ER) stress in brain hypothalamus and pancreatic islets, thereby ameliorating metabolic derangement in high fat diet (HFD)-induced obese diabetic mice. However, extremely low absorption efficiency from intestine of γ-oryzanol is a tough obstacle for the clinical application. Therefore, in this study, to overcome extremely low bioavailability of γ-oryzanol with super-high lipophilicity, we encapsulated γ-oryzanol in polymer poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (Nano-Orz), and evaluated its metabolically beneficial impact in genetically obese-diabetic ob/ob mice, the best-known severest diabetic model in mice. To our surprise, Nano-Orz markedly ameliorated fuel metabolism with an unexpected magnitude (∼1000-fold lower dose) compared with regular γ-oryzanol. Furthermore, such a conspicuous impact was achievable by its administration once every 2 weeks. Besides the excellent impact on dysfunction of hypothalamus and pancreatic islets, Nano-Orz markedly decreased ER stress and inflammation in liver and adipose tissue. Collectively, nanotechnology-based developments of functional foods oriented toward γ-oryzanol shed light on the novel approach for the treatment of a variety of metabolic diseases in humans.

  18. Digital signage sobre IP

    OpenAIRE

    Casademont Filella, Albert

    2012-01-01

    Projecte que versa sobre el disseny i la implementació d'un sistema de Digital Signage (Cartelleria Digital) sobre IP, creant un gestor que permeti controlar de forma remota tot un conjunt de petits dispositius connectats a pantalles que emeten continguts multimèdia com vídeos, imatges, feeds rss...

  19. Further RIOTS4 Characterization of Field OB Stars in the SMC

    Science.gov (United States)

    Oey, M. S.; Barnes, Jesse R.; Paggeot, Kevin J.; Dorigo Jones, John; Castro, Norberto; Simon-Diaz, Sergio; Kratter, Kaitlin M.; Moe, Maxwell; Szymanski, Michal

    2018-06-01

    We present recent results from the Runaways and O-Type Star Spectroscopic Survey of the SMC (RIOTS4), a survey quantifying properties of the field OB stars in the Small Magellanic Cloud (SMC). Based on PSF-fitting photometry and astrometry of OGLE-III I-band images, we quantify the degree of isolation for the target OB stars, classifying them as "tip-of-the-iceberg" stars accompanied by small, sparse, clusters; or as true, isolated field stars. Many of these field stars must be runaways, which we evaluate using GAIA DR2 proper motions. We measure v sin i using the IACOB code Fourier analysis, finding that the bimodal distribution of projected rotation velocities is less pronounced for O stars than early B stars. We examine rotation in relation to relative isolation and runaway status.

  20. BOREAS TF-3 Automated Chamber CO2 Flux Data from the NSA-OBS

    Science.gov (United States)

    Goulden, Michael L.; Crill, Patrick M.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOReal Ecosystem Atmosphere Study Tower Flux (BOREAS TF-3) and Trace Gas Biogeochemistry (TGB-1) teams collected automated CO2 chamber flux data in their efforts to fully describe the CO2 flux at the Northern Study Area-Old Black Spruce (NSA-OBS) site. This data set contains fluxes of CO2 at the NSA-OBS site measured using automated chambers. In addition to reporting the CO2 flux, it reports chamber air temperature, moss temperature, and light levels during each measurement. The data set covers the period from 23-Sep-1995 through 26-Oct-1995 and from 28-May-1996 through 21-Oct-1996. The data are stored in tabular ASCII files.

  1. Conversion of chlorinated propanes by Methylosinus trichosporium OB3b expressing soluble methane monooxygenase

    OpenAIRE

    Bosma, T.; Janssen, D.B.

    1998-01-01

    Chlorinated propanes are important pollutants that may show persistent behaviour in the environment. The biotransformation of 1-chloropropane, 1,2-dichloropropane, 1,3-dichloropropane and 1,2,3-trichloropropane was studied using resting cell suspensions of Methylosinus trichosporium OB3b expressing soluble methane monooxygenase. The transformation followed first-order kinetics. The rate constants were in the order 1-chloropropane > 1,3-dichloropropane > 1,2-dichloropropane > 1,2,3-trichloropr...

  2. ObStruct: a method to objectively analyse factors driving population structure using Bayesian ancestry profiles.

    Directory of Open Access Journals (Sweden)

    Velimir Gayevskiy

    Full Text Available Bayesian inference methods are extensively used to detect the presence of population structure given genetic data. The primary output of software implementing these methods are ancestry profiles of sampled individuals. While these profiles robustly partition the data into subgroups, currently there is no objective method to determine whether the fixed factor of interest (e.g. geographic origin correlates with inferred subgroups or not, and if so, which populations are driving this correlation. We present ObStruct, a novel tool to objectively analyse the nature of structure revealed in Bayesian ancestry profiles using established statistical methods. ObStruct evaluates the extent of structural similarity between sampled and inferred populations, tests the significance of population differentiation, provides information on the contribution of sampled and inferred populations to the observed structure and crucially determines whether the predetermined factor of interest correlates with inferred population structure. Analyses of simulated and experimental data highlight ObStruct's ability to objectively assess the nature of structure in populations. We show the method is capable of capturing an increase in the level of structure with increasing time since divergence between simulated populations. Further, we applied the method to a highly structured dataset of 1,484 humans from seven continents and a less structured dataset of 179 Saccharomyces cerevisiae from three regions in New Zealand. Our results show that ObStruct provides an objective metric to classify the degree, drivers and significance of inferred structure, as well as providing novel insights into the relationships between sampled populations, and adds a final step to the pipeline for population structure analyses.

  3. Obésité abdominale et autres biomarqueurs de risque ...

    African Journals Online (AJOL)

    Obésité abdominale et autres biomarqueurs de risque cardiométabolique: influence du niveau socioéconomique et du mode de vie dans deux populations noires apparentées, Cotonou (Bénin) et Port-au-Prince (Haïti). Asma EL Mabchour, Hélène Delisle, Colette Vilgrain, Phillipe Larco, Roger Sodjinou ...

  4. Bioinformatics analysis identify novel OB fold protein coding genes in C. elegans.

    Directory of Open Access Journals (Sweden)

    Daryanaz Dargahi

    Full Text Available BACKGROUND: The C. elegans genome has been extensively annotated by the WormBase consortium that uses state of the art bioinformatics pipelines, functional genomics and manual curation approaches. As a result, the identification of novel genes in silico in this model organism is becoming more challenging requiring new approaches. The Oligonucleotide-oligosaccharide binding (OB fold is a highly divergent protein family, in which protein sequences, in spite of having the same fold, share very little sequence identity (5-25%. Therefore, evidence from sequence-based annotation may not be sufficient to identify all the members of this family. In C. elegans, the number of OB-fold proteins reported is remarkably low (n=46 compared to other evolutionary-related eukaryotes, such as yeast S. cerevisiae (n=344 or fruit fly D. melanogaster (n=84. Gene loss during evolution or differences in the level of annotation for this protein family, may explain these discrepancies. METHODOLOGY/PRINCIPAL FINDINGS: This study examines the possibility that novel OB-fold coding genes exist in the worm. We developed a bioinformatics approach that uses the most sensitive sequence-sequence, sequence-profile and profile-profile similarity search methods followed by 3D-structure prediction as a filtering step to eliminate false positive candidate sequences. We have predicted 18 coding genes containing the OB-fold that have remarkably partially been characterized in C. elegans. CONCLUSIONS/SIGNIFICANCE: This study raises the possibility that the annotation of highly divergent protein fold families can be improved in C. elegans. Similar strategies could be implemented for large scale analysis by the WormBase consortium when novel versions of the genome sequence of C. elegans, or other evolutionary related species are being released. This approach is of general interest to the scientific community since it can be used to annotate any genome.

  5. Diacylglycerol production induced by growth hormone in Ob1771 preadipocytes arises from phosphatidylcholine breakdown

    International Nuclear Information System (INIS)

    Catalioto, R.M.; Ailhaud, G.; Negrel, R.

    1990-01-01

    Growth Hormone has recently been shown to stimulate the formation of diacylglycerol in Ob1771 mouse preadipocyte cells without increasing inositol lipid turnover. Addition of growth hormone to Ob1771 cells prelabelled with [ 3 H]glycerol or [ 3 H]choline led to a rapid, transient and stoechiometric formation of labelled diacylglycerol and phosphocholine, respectively. In contrast, no change was observed in the level of choline and phosphatidic acid whereas the release of water-soluble metabolites in [ 3 H]ethanolamine prelabelled cells exposed to growth hormone was hardly detectable. Stimulation by growth hormone of cells prelabelled with (2-palmitoyl 9, 10 [ 3 H])phosphatidylcholine also induced the production of labelled diacyglycerol. Pertussis toxin abolished both diacylglycerol and phosphocholine formation induced by growth hormone. It is concluded that growth hormone mediates diacylglycerol production in Ob1771 cells by means of phosphatidylcholine breakdown involving a phospholipase C which is likely coupled to the growth hormone receptor via a pertussis toxin-sensitive G-protein

  6. Relative Stabilities of Conserved and Non-Conserved Structures in the OB-Fold Superfamily

    Directory of Open Access Journals (Sweden)

    Andrei T. Alexandrescu

    2009-05-01

    Full Text Available The OB-fold is a diverse structure superfamily based on a β-barrel motif that is often supplemented with additional non-conserved secondary structures. Previous deletion mutagenesis and NMR hydrogen exchange studies of three OB-fold proteins showed that the structural stabilities of sites within the conserved β-barrels were larger than sites in non-conserved segments. In this work we examined a database of 80 representative domain structures currently classified as OB-folds, to establish the basis of this effect. Residue-specific values were obtained for the number of Cα-Cα distance contacts, sequence hydrophobicities, crystallographic B-factors, and theoretical B-factors calculated from a Gaussian Network Model. All four parameters point to a larger average flexibility for the non-conserved structures compared to the conserved β-barrels. The theoretical B-factors and contact densities show the highest sensitivity.Our results suggest a model of protein structure evolution in which novel structural features develop at the periphery of conserved motifs. Core residues are more resistant to structural changes during evolution since their substitution would disrupt a larger number of interactions. Similar factors are likely to account for the differences in stability to unfolding between conserved and non-conserved structures.

  7. Improvements to the gridding of precipitation data across Europe under the E-OBS scheme

    Science.gov (United States)

    Cornes, Richard; van den Besselaar, Else; Jones, Phil; van der Schrier, Gerard; Verver, Ge

    2016-04-01

    Gridded precipitation data are a valuable resource for analyzing past variations and trends in the hydroclimate. Such data also provide a reference against which model simulations may be driven, compared and/or adjusted. The E-OBS precipitation dataset is widely used for such analyses across Europe, and is particularly valuable since it provides a spatially complete, daily field across the European domain. In this analysis, improvements to the E-OBS precipitation dataset will be presented that aim to provide a more reliable estimate of grid-box precipitation values, particularly in mountainous areas and in regions with a relative sparsity of input station data. The established three-stage E-OBS gridding scheme is retained, whereby monthly precipitation totals are gridded using a thin-plate spline; daily anomalies are gridded using indicator kriging; and the final dataset is produced by multiplying the two grids. The current analysis focuses on improving the monthly thin-plate spline, which has overall control on the final daily dataset. The results from different techniques are compared and the influence on the final daily data is assessed by comparing the data against gridded country-wide datasets produced by various National Meteorological Services

  8. An unidentified TeV source in the vicinity of Cygnus OB2

    Science.gov (United States)

    Aharonian, F.; Akhperjanian, A.; Beilicke, M.; Bernlöhr, K.; Börst, H.; Bojahr, H.; Bolz, O.; Coarasa, T.; Contreras, J.; Cortina, J.; Denninghoff, S.; Fonseca, V.; Girma, M.; Götting, N.; Heinzelmann, G.; Hermann, G.; Heusler, A.; Hofmann, W.; Horns, D.; Jung, I.; Kankanyan, R.; Kestel, M.; Kettler, J.; Kohnle, A.; Konopelko, A.; Kornmeyer, H.; Kranich, D.; Krawczynski, H.; Lampeitl, H.; Lopez, M.; Lorenz, E.; Lucarelli, F.; Magnussen, N.; Mang, O.; Meyer, H.; Milite, M.; Mirzoyan, R.; Moralejo, A.; Ona, E.; Panter, M.; Plyasheshnikov, A.; Prahl, J.; Pühlhofer, G.; Rauterberg, G.; Reyes, R.; Rhode, W.; Ripken, J.; Röhring, A.; Rowell, G. P.; Sahakian, V.; Samorski, M.; Schilling, M.; Schröder, F.; Siems, M.; Sobzynska, D.; Stamm, W.; Tluczykont, M.; Völk, H. J.; Wiedner, C. A.; Wittek, W.; Uchiyama, Y.; Takahashi, T.; HEGRA Collaboration

    2002-10-01

    Deep observation ( ~ 113 hrs) of the Cygnus region at TeV energies using the HEGRA stereoscopic system of air Čerenkov telescopes has serendipitously revealed a signal positionally inside the core of the OB association Cygnus OB2, at the edge of the 95% error circle of the EGRET source 3EG J2033+4118, and ~ 0.5o north of Cyg X-3. The source centre of gravity is RA alphaJ2000: 20h 32m 07s+/- 9.2sstat +/-2.2ssys, Dec deltaJ2000: +41o 30' 30''+/- 2.0'stat +/- 0.4'sys. The source is steady, has a post-trial significance of +4.6sigma , indication for extension with radius 5.6' at the ~ 3sigma level, and has a differential power-law flux with hard photon index of -1.9 +/-0.3stat +/-0.3sys. The integral flux above 1 TeV amounts ~ 3% that of the Crab. No counterpart for the TeV source at other wavelengths is presently identified, and its extension would disfavour an exclusive pulsar or AGN origin. If associated with Cygnus OB2, this dense concentration of young, massive stars provides an environment conducive to multi-TeV particle acceleration and likely subsequent interaction with a nearby gas cloud. Alternatively, one could envisage gamma -ray production via a jet-driven termination shock.

  9. A model for the infrared emission from an OB star cluster environment

    International Nuclear Information System (INIS)

    Leisawitz, D.

    1990-01-01

    Researchers developed an interactive radiative transfer code that predicts the infrared emission from an HII region containing diffuse ionized and atomic gas and dense molecular clouds. This model complements the investigation of the redistribution of OB star luminosity in the interstellar medium (Leisawitz and Hauser 1988, Ap. J., 332, 954). The model can be used as a diagnostic tool to probe the radiation field and matter density in an HII region, place constraints on the proximity and orientation of an illuminated molecular cloud with respect to the ionizing stars, test for the presence of small, transiently heated dust grains, and determine whether the dust-to-gas ratio is normal. Predictions of the model agree qualitatively and quantitatively with observations of blister-type HII regions ionized by well-studied OB clusters in which the distribution of dense neutral material is known. This is illustrated by a model for Infrared Astronomy Satellite (IRAS) observations of the region around NGC 7380 (S142). Researchers plan to use the model in a survey of regions of massive star formation in the outer Galaxy to study OB stars embedded to various degrees in their parental molecular clouds

  10. ObsPy – What can it do for data centers and observatories?

    Directory of Open Access Journals (Sweden)

    Joachim Wassermann

    2011-04-01

    Full Text Available Data acquisition by seismic centers relies on real-time systems, like SeisComP3, Antelope and Earthworm. However, these are complex systems that are designed for fast and precisely defined standard real-time analyses. Therefore, it is not a simple task to access or modify internal routines, and to integrate them into custom-processing workflows or to perform in-depth data analyses. Often a library is necessary that provides convenient access to data and allows easy control over all of the operations that are to be performed on the data. ObsPy is such a library, which is designed to access and process seismological waveform data and metadata. We use short and simple examples here to demonstrate how effective it is to use Python for seismological data analysis. Then, we illustrate the general capabilities of ObsPy, and highlight some of its specific aspects that are relevant for seismological data centers and observatories, through presentation of real-world examples. Finally, we demonstrate how the ObsPy library can be used to develop custom graphical user interface applications.

  11. Diacylglycerol production induced by growth hormone in Ob1771 preadipocytes arises from phosphatidylcholine breakdown

    Energy Technology Data Exchange (ETDEWEB)

    Catalioto, R.M.; Ailhaud, G.; Negrel, R. (Universite de Nice-Sophia Antipolis (France))

    1990-12-31

    Growth Hormone has recently been shown to stimulate the formation of diacylglycerol in Ob1771 mouse preadipocyte cells without increasing inositol lipid turnover. Addition of growth hormone to Ob1771 cells prelabelled with ({sup 3}H)glycerol or ({sup 3}H)choline led to a rapid, transient and stoechiometric formation of labelled diacylglycerol and phosphocholine, respectively. In contrast, no change was observed in the level of choline and phosphatidic acid whereas the release of water-soluble metabolites in ({sup 3}H)ethanolamine prelabelled cells exposed to growth hormone was hardly detectable. Stimulation by growth hormone of cells prelabelled with (2-palmitoyl 9, 10 ({sup 3}H))phosphatidylcholine also induced the production of labelled diacyglycerol. Pertussis toxin abolished both diacylglycerol and phosphocholine formation induced by growth hormone. It is concluded that growth hormone mediates diacylglycerol production in Ob1771 cells by means of phosphatidylcholine breakdown involving a phospholipase C which is likely coupled to the growth hormone receptor via a pertussis toxin-sensitive G-protein.

  12. A M2FS Spectroscopic Study of Low-mass Young Stars in Orion OB1

    Science.gov (United States)

    Kaleida, Catherine C.; Briceno, Cesar; Calvet, Nuria; Mateo, Mario L.; Hernandez, Jesus

    2015-01-01

    Surveys of pre-main sequence stars in the ~4-10 Myr range provide a window into the decline of the accretion phase of stars and the formation of planets. Nearby star clusters and stellar associations allow for the study of these young stellar populations all the way down to the lowest mass members. One of the best examples of nearby 4-10 Myr old stellar populations is the Orion OB1 association. The CIDA Variability Survey of Orion OB1 (CVSO - Briceño et al. 2001) has used the variability properties of low-mass pre-main-sequence (PMS) stars to identify hundreds of K and M-type stellar members of the Orion OB1 association, a number of them displaying IR-excess emission and thought to be representative of more evolved disk-bearing young stars. Characterizing these young, low-mass objects using spectroscopy is integral to understanding the accretion phase in young stars. We present preliminary results of a spectroscopic survey of candidate and confirmed Orion OB1 low-mass members taken during November 2014 and February 2014 using the Michigan/Magellan Fiber Spectrograph (M2FS), a PI instrument on the Magellan Clay Telescope (PI: M. Matteo). Target fields located in the off-cloud regions of Orion were identified in the CVSO, and observed using the low and high-resolution modes of M2FS. Both low and high-resolution spectra are needed in order to confirm membership and derive masses, ages, kinematics and accretion properties. Initial analysis of these spectra reveal many new K and M-type members of the Orion OB1 association in these low extinction, off-cloud areas. These are the more evolved siblings of the youngest stars still embedded in the molecular clouds, like those in the Orion Nebula Cluster. With membership and spectroscopic indicators of accretion we are building the most comprehensive stellar census of this association, enabling us to derive a robust estimate of the fraction of young stars still accreting at a various ages, a key constraint for the end of

  13. Apuntes sobre esporotricosis

    OpenAIRE

    Londoño, Fabio

    2011-01-01

    Se hace una breve reseña histórica de las primeras comunicaciones sobre esporotricosis. Se destaca la amplia difusión de la enfermedad en nuestro país. 3. Se hace notar la no existencia de datos bibliográficos sobre formas extracutáneas. 4. Se llama la atención sobre la eficaz ayuda de la intradermo-reacción con esporotriquina en el diagnóstico de la enfermedad. 5- Se comunica un caso de esporotricosis verrugosa tratado con anfotericin B, con excelentes resultados

  14. Apuntes sobre esporotricosis

    Directory of Open Access Journals (Sweden)

    Fabio Londoño

    1960-01-01

    Full Text Available Se hace una breve reseña histórica de las primeras comunicaciones sobre esporotricosis. Se destaca la amplia difusión de la enfermedad en nuestro país. 3. Se hace notar la no existencia de datos bibliográficos sobre formas extracutáneas. 4. Se llama la atención sobre la eficaz ayuda de la intradermo-reacción con esporotriquina en el diagnóstico de la enfermedad. 5- Se comunica un caso de esporotricosis verrugosa tratado con anfotericin B, con excelentes resultados

  15. VizieR Online Data Catalog: Properties of OB associations in IC 1613 (Garcia+, 2010)

    Science.gov (United States)

    Garcia, M.; Herrero, A.; Castro, N.; Corral, L.; Rosenberg, A.

    2014-06-01

    To understand the structure and evolution of massive stars, systematic surveys of the Local Group galaxies have been undertaken, to find these objects in environments of different chemical abundances. We focus on the metal-poor irregular galaxy IC 1613 to analyze the stellar and wind structure of its low-metallicity massive stars. We ultimately aim to study the metallicity-dependent driving mechanism of the winds of blue massive stars and use metal-poor massive stars of the Local Volume as a proxy for the stars in the early Universe. In a previous paper we produced a list of OB associations in IC 1613. Their properties are not only a powerful aid towards finding the most interesting candidate massive stars, but also reveal the structure and recent star formation history of the galaxy. We characterize these OB associations and study their connection with the galactic global properties. The reddening-free Q parameter is a powerful tool in the photometric analysis of young populations of massive stars, since it exhibits a smaller degree of degeneracy with OB spectral types than the B-V color. The color-magnitude diagram (Q vs. V) of the OB associations in IC 1613 is studied to determine their age and mass, and confirm the population of young massive stars. We identified more than 10 stars with M>=50M⊙. Spectral classification available for some of them confirm their massive nature, yet we find the common discrepancy with the spectroscopically derived masses. There is a general increasing trend of the mass of the most massive member with the number of members of each association, but not with the stellar density. The average diameter of the associations of this catalog is 40pc, half the historically considered typical size of OB associations. Size increases with the association population. The distribution of the groups strongly correlates with that of neutral and ionized hydrogen. We find the largest dispersion of association ages in the bubble region of the galaxy

  16. IPV Screening and Readiness to Respond to IPV in Ob-Gyn Settings: A Patient-Physician Study

    Directory of Open Access Journals (Sweden)

    Katherine M. Jones

    2018-01-01

    Full Text Available Purpose. Intimate partner violence (IPV is a serious, preventable public health concern that largely affects women of reproductive age. Obstetrician-gynecologists (ob-gyns have a unique opportunity to identify and support women experiencing IPV to improve women’s health. Considering recent efforts to increase IPV awareness and intervention, the present study aimed to provide a current evaluation of nationally representative samples to assess ob-gyn readiness to respond to IPV as well as patient IPV-related experiences. Methods. 400 ob-gyns were randomly selected from American College of Obstetricians and Gynecologists’ (ACOG Collaborative Ambulatory Research Network. Each physician was mailed one physician survey and 25 patient surveys. Results. IPV training/education and IPV screening practices were associated with most measures of ob-gyn readiness to respond to IPV. Among respondents, 36.8% endorsed screening all patients at annual exams; however, 36.8% felt they did not have sufficient training to assist individuals in addressing IPV. Workplace encouragement of IPV response was associated with training, screening, detection, preparation/knowledge, response practices, and resources. Thirty-one percent of patients indicated their ob-gyn had asked about possible IPV experiences during their medical visit. Conclusion. Findings highlight specific gaps in ob-gyns’ IPV knowledge and response practices to be further addressed by IPV training.

  17. Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob/ob)

    Science.gov (United States)

    Mizuno, Márcia Sanae; Crisma, Amanda Rabello; Borelli, Primavera; Schäfer, Bárbara Tavares; Silveira, Mariana Póvoa; Castelucci, Patricia

    2014-01-01

    AIM: To investigate the colocalization, density and profile of neuronal areas of enteric neurons in the ileum of male obese mice. METHODS: The small intestinal samples of male mice in an obese group (OG) (C57BL/6J ob/ob) and a control group (CG) (+/+) were used. The tissues were analyzed using a double immunostaining technique for immunoreactivity (ir) of the P2X2 receptor, nitric oxide synthase (NOS), choline acetyl transferase (ChAT) and calretinin (Calr). Also, we investigated the density and profile of neuronal areas of the NOS-, ChAT- and Calr-ir neurons in the myenteric plexus. Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method. RESULTS: The analysis demonstrated that the P2X2 receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG. Neuronal density values (neuron/cm2) decreased 31% (CG: 6579 ± 837; OG: 4556 ± 407) and 16.5% (CG: 7796 ± 528; OG: 6513 ± 610) in the NOS-ir and calretinin-ir neurons in the OG, respectively (P < 0.05). Density of ChAT-ir (CG: 6200 ± 310; OG: 8125 ± 749) neurons significantly increased 31% in the OG (P < 0.05). Neuron size studies demonstrated that NOS, ChAT, and Calr-ir neurons did not differ significantly between the CG and OG groups. The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG. CONCLUSION: Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir, ChAT-ir and CalR-ir myenteric neurons. PMID:25320527

  18. MUG-OBS - Multiparameter Geophysical Ocean Bottom System : a new instrumental approach to monitor earthquakes.

    Science.gov (United States)

    hello, yann; Charvis, Philippe; Yegikyan, Manuk; verfaillie, Romain; Rivet, Diane

    2016-04-01

    Real time monitoring of seismic activity is a major issue for early warning of earthquakes and tsunamis. It can be done using regional scale wired nodes, such as Neptune in Canada and in the U.S, or DONET in Japan. Another approach to monitor seismic activity at sea is to deploying repeatedly OBS array like during the amphibious Cascadia Initiative (four time 1-year deployments), the Japanese Pacific Array (broadband OBSs "ocean-bottom broadband dispersion survey" with 2-years autonomy), the Obsismer program in the French Lesser Antilles (eight time 6-months deployments) and the Osisec program in Ecuador (four time 6-months deployments). These autonomous OBSs are self-recovered or recovered using an ROV. These systems are costly including ship time, and require to recover the OBS before to start working on data. Among the most recent alternative we developed a 3/4 years autonomy ocean bottom system with 9 channels (?) allowing the acquisition of different seismic or environmental parameters. MUG-OBS is a free falling instrument rated down to 6000 m. The installation of the sensor is monitored by acoustic commands from the surface and a health bulletin with data checking is recovered by acoustic during the installation. The major innovation is that it is possible to recover the data any time on demand (regularly every 6-months or after a crisis) using one of the 6 data-shuttles released from the surface by acoustic command using a one day fast cruise boat of opportunity. Since sensors stayed at the same location for 3 years, it is a perfect tool to monitor large seismic events, background seismic activity and aftershock distribution. Clock, drift measurement and GPS localization is automatic when the shuttle reaches the surface. For remote areas, shuttles released automatically and a seismic events bulletin is transmitted. Selected data can be recovered by two-way Iridium satellite communication. After a period of 3 years the main station is self-recovered by

  19. Not all stars form in clusters - measuring the kinematics of OB associations with Gaia

    Science.gov (United States)

    Ward, Jacob L.; Kruijssen, J. M. Diederik

    2018-04-01

    It is often stated that star clusters are the fundamental units of star formation and that most (if not all) stars form in dense stellar clusters. In this monolithic formation scenario, low-density OB associations are formed from the expansion of gravitationally bound clusters following gas expulsion due to stellar feedback. N-body simulations of this process show that OB associations formed this way retain signs of expansion and elevated radial anisotropy over tens of Myr. However, recent theoretical and observational studies suggest that star formation is a hierarchical process, following the fractal nature of natal molecular clouds and allowing the formation of large-scale associations in situ. We distinguish between these two scenarios by characterizing the kinematics of OB associations using the Tycho-Gaia Astrometric Solution catalogue. To this end, we quantify four key kinematic diagnostics: the number ratio of stars with positive radial velocities to those with negative radial velocities, the median radial velocity, the median radial velocity normalized by the tangential velocity, and the radial anisotropy parameter. Each quantity presents a useful diagnostic of whether the association was more compact in the past. We compare these diagnostics to models representing random motion and the expanding products of monolithic cluster formation. None of these diagnostics show evidence of expansion, either from a single cluster or multiple clusters, and the observed kinematics are better represented by a random velocity distribution. This result favours the hierarchical star formation model in which a minority of stars forms in bound clusters and large-scale, hierarchically structured associations are formed in situ.

  20. WNIN/GR-Ob - an insulin-resistant obese rat model from inbred WNIN strain.

    Science.gov (United States)

    Harishankar, N; Vajreswari, A; Giridharan, N V

    2011-09-01

    WNIN/GR-Ob is a mutant obese rat strain with impaired glucose tolerance (IGT) developed at the National Institute of Nutrition (NIN), Hyderabad, India, from the existing 80 year old Wistar rat (WNIN) stock colony. The data presented here pertain to its obese nature along with IGT trait as evidenced by physical, physiological and biochemical parameters. The study also explains its existence, in three phenotypes: homozygous lean (+/+), heterozygous carrier (+/-) and homozygous obese (-/-). Thirty animals (15 males and 15 females) from each phenotype (+/+, +/-, -/-) and 24 lean and obese (6 males and 6 females) rats were taken for growth and food intake studies respectively. Twelve adult rats from each phenotype were taken for body composition measurement by total body electrical conductivity (TOBEC); 12 rats of both genders from each phenotype at different ages were taken for clinical chemistry parameters. Physiological indices of insulin resistance were calculated according to the homeostasis model assessment for insulin resistance (HOMA-IR) and also by studying U¹⁴C 2-deoxy glucose uptake (2DG). WNINGR-Ob mutants had high growth, hyperphagia, polydipsia, polyurea, glycosuria, and significantly lower lean body mass, higher fat mass as compared with carrier and lean rats. These mutants, at 50 days of age displayed abnormal response to glucose load (IGT), hyperinsulinaemia, hypertriglyceridaemia, hypercholesterolaemia and hyperleptinaemia. Basal and insulin-stimulated glucose uptakes by diaphragm were significantly decreased in obese rats as compared with lean rats. Obese rats of the designated WNIN/GR-Ob strain showed obesity with IGT, as adjudged by physical, physiological and biochemical indices. These indices varied among the three phenotypes, being lowest in lean, highest in obese and intermediate in carrier phenotypes thereby suggesting that obesity is inherited as autosomal incomplete dominant trait in this strain. This mutant obese rat model is easy to

  1. Development of the TeamOBS-PPH - targeting clinical performance in postpartum hemorrhage.

    Science.gov (United States)

    Brogaard, Lise; Hvidman, Lone; Hinshaw, Kim; Kierkegaard, Ole; Manser, Tanja; Musaeus, Peter; Arafeh, Julie; Daniels, Kay I; Judy, Amy E; Uldbjerg, Niels

    2018-06-01

    This study aimed to develop a valid and reliable TeamOBS-PPH tool for assessing clinical performance in the management of postpartum hemorrhage (PPH). The tool was evaluated using video-recordings of teams managing PPH in both real-life and simulated settings. A Delphi panel consisting of 12 obstetricians from the UK, Norway, Sweden, Iceland, and Denmark achieved consensus on (i) the elements to include in the assessment tool, (ii) the weighting of each element, and (iii) the final tool. The validity and reliability were evaluated according to Cook and Beckman. (Level 1) Four raters scored four video-recordings of in situ simulations of PPH. (Level 2) Two raters scored 85 video-recordings of real-life teams managing patients with PPH ≥1000 mL in two Danish hospitals. (Level 3) Two raters scored 15 video-recordings of in situ simulations of PPH from a US hospital. The tool was designed with scores from 0 to 100. (Level 1) Teams of novices had a median score of 54 (95% CI 48-60), whereas experienced teams had a median score of 75 (95% CI 71-79; p < 0.001). (Level 2) The intra-rater [intra-class correlation (ICC) = 0.96] and inter-rater (ICC = 0.83) agreements for real-life PPH were strong. The tool was applicable in all cases: atony, retained placenta, and lacerations. (Level 3) The tool was easily adapted to in situ simulation settings in the USA (ICC = 0.86). The TeamOBS-PPH tool appears to be valid and reliable for assessing clinical performance in real-life and simulated settings. The tool will be shared as the free TeamOBS App. © 2018 Nordic Federation of Societies of Obstetrics and Gynecology.

  2. OB ASSOCIATIONS AT THE UPPER END OF THE MILKY WAY LUMINOSITY FUNCTION

    Energy Technology Data Exchange (ETDEWEB)

    Rahman, Mubdi; Matzner, Christopher D.; Moon, Dae-Sik, E-mail: mubdi@pha.jhu.edu [Department of Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, ON M5S 3H8 (Canada)

    2013-04-01

    The Milky Way's most luminous, young, and massive (M {approx}> 10{sup 4} M{sub Sun }) star clusters and OB associations have largely evaded detection despite knowledge of their surrounding H II regions. We search for these clusters and associations within the 40 star-forming complexes from Rahman and Murray in the 13 most luminous Wilkinson Microwave Anisotropy Probe (WMAP) free-free emission sources of the Galaxy. Selecting for objects with the dust-reddened colors of OB stars, we identify new candidate associations using the Two Micron All Sky Survey point-source catalog. In 40 star-forming complexes searched, 22 contain cluster/association candidates with sizes and masses in the range of 3'-26' and 10{sup 2.3}-10{sup 5} M{sub Sun }. Of the 22 candidates, at least seven have estimated masses {approx}> 10{sup 4} M{sub Sun }, doubling the number of such massive clusters known in the Galaxy. Only one of the searched WMAP sources remains without a candidate. Applying our method to a statistically similar set of test locations, we estimate that 3.0 {+-} 0.6 of our 22 candidate associations are unrelated to the star-forming complexes. In addition, the apparent extinctions of our candidate associations correlate well with the predictions from a Galactic model. These facts, along with the clear detection of a known OB association and the previous spectral verification of one cluster found by this method, validate our method. In eight of the most luminous WMAP sources, the candidate associations can account for the observed free-free flux. With our new compilation, the Galactic census of young, massive stellar associations may now be about half complete.

  3. A Multi-Fiber Spectroscopic Search for Low-mass Young Stars in Orion OB1

    Science.gov (United States)

    Loerincs, Jacqueline; Briceno, Cesar; Calvet, Nuria; Mateo, Mario L.; Hernandez, Jesus

    2017-01-01

    We present here results of a low resolution spectroscopic followup of candidate low-mass pre-main sequence stars in the Orion OB1 association. Our targets were selected from the CIDA Variability Survey of Orion (CVSO), and we used the Michigan/Magellan Fiber Spectrograph (M2FS) on the Magellan Clay 6.5m telescope to obtain spectra of 500 candidate T Tauri stars distributed in seven 0.5 deg diameter fields, adding to a total area of ~5.5 deg2. We identify young stars by looking at the distinctive Hα 6563 Å emission and Lithium Li I 6707 Å absorption features characteristic of young low mass pre-main sequence stars. Furthermore, by measuring the strength of their Hα emission lines, confirmed T Tauri stars can be classified as either Classical T Tauris (CTTS) or Weak-line T Tauris (WTTS), which give indication of whether the star is actively accreting material from a gas and dust disk surrounding the star, which may be the precursor of a planetary system. We confirm a total of 90 T Tauri stars, of which 50% are newly identified young members of Orion; out of the 49 new detections,15 are accreting CTTS, and of these all but one are found in the OB1b sub-region. This result is in line with our previous findings that this region is much younger than the more extended Orion OB1a sub-association. The M2FS results add to our growing census of young stars in Orion, that is allowing us to characterize in a systematic and consistent way the distribution of stellar ages across the entire complex, in order to building a complete picture of star formation in this, one of nearest most active sites of star birth.

  4. Nature vs. Nurture: The influence of OB star environments on proto-planetary disk evolution

    Science.gov (United States)

    Bouwman, Jeroen

    2006-09-01

    We propose a combined IRAC/IRS study of a large, well-defined and unbiased X-ray selected sample of pre-main-sequence stars in three OB associations: Pismis 24 in NGC 6357, NGC 2244 in the Rosette Nebula, and IC 1795 in the W3 complex. The samples are based on recent Chandra X-ray Observatory studies which reliably identify hundreds of cluster members and were carefully chosen to avoid high infrared nebular background. A new Chandra exposure of IC 1795 is requested, and an optical followup to characterise the host stars is planned.

  5. Direct Imaging and Spectroscopy of a Young Extrasolar Kuiper Belt in the Nearest OB Association

    OpenAIRE

    Currie, Thayne; Lisse, Carey M.; Kuchner, Marc J.; Madhusudhan, Nikku; Kenyon, Scott J.; Thalmann, Christian; Carson, Joseph; Debes, John H.

    2015-01-01

    We describe the discovery of a bright, young Kuiper belt-like debris disk around HD 115600, a $\\sim$ 1.4--1.5 M$_\\mathrm{\\odot}$, $\\sim$ 15 Myr old member of the Sco-Cen OB Association. Our H-band coronagraphy/integral field spectroscopy from the \\textit{Gemini Planet Imager} shows the ring has a (luminosity scaled) semi major axis of ($\\sim$ 22 AU) $\\sim$ 48 AU, similar to the current Kuiper belt. The disk appears to have neutral scattering dust, is eccentric (e $\\sim$ 0.1--0.2), and could b...

  6. Eukaryotic RNA polymerase subunit RPB8 is a new relative of the OB family.

    Science.gov (United States)

    Krapp, S; Kelly, G; Reischl, J; Weinzierl, R O; Matthews, S

    1998-02-01

    RNA polymerase II subunit RPB8 is an essential subunit that is highly conserved throughout eukaryotic evolution and is present in all three types of nuclear RNA polymerases. We report the first high resolution structural insight into eukaryotic RNA polymerase architecture with the solution structure of RPB8 from Saccharomyces cerevisiae. It consists of an eight stranded, antiparallel beta-barrel, four short helical regions and a large, unstructured omega-loop. The strands are connected in classic Greek-key fashion. The overall topology is unusual and contains a striking C2 rotational symmetry. Furthermore, it is most likely a novel associate of the oligonucleotide/oligosaccharide (OB) binding protein class.

  7. BOREAS TF-8 NSA-OJP and SSA-OBS Ceilometer Data

    Science.gov (United States)

    Moore, Kathleen E.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Fitzjarrald, David R.

    2000-01-01

    The BOREAS TF-8 team used ceilometers to collect data on the fraction of the sky covered with clouds and the cloud height. Included with these data is the surface-based lifting condensation level, derived from temperature and humidity values acquired at the flux tower at the NSA-OJP site. Ceilo-meter data were collected at the NSA-OJP site in 1994 and at the NSA-OJP and SSA-OBS sites in 1996. The data are available in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884).

  8. Adipose cell differentiation: evidence for a two-step process in the polyamine-dependent Ob1754 clonal line.

    Science.gov (United States)

    Amri, E Z; Dani, C; Doglio, A; Etienne, J; Grimaldi, P; Ailhaud, G

    1986-01-01

    A subclone of preadipocyte Ob17 cells has been isolated (Ob1754 clonal line). Confluent Ob1754 cells treated with an inhibitor of spermidine and spermine synthesis, methylglyoxal bis(guanylhydrazone), were totally dependent upon putrescine addition for the expression of glycerol-3-phosphate dehydrogenase which behaved as a late marker of adipose conversion. Under these conditions, the early expression of lipoprotein lipase during growth arrest remained unchanged. Studies at the mRNA level showed that the expression of unidentified pOb24 and pGH3 mRNAs, which was parallel to that of lipoprotein lipase, is independent of polyamine addition whereas the late emergence of glycerol-3-phosphate dehydrogenase mRNA was putrescine-dependent and co-ordinated with the expression of pAL422 mRNA encoding for a myelin-P2 homologue [Bernlohr, Angus, Lane, Bolanowski & Kelly (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 5468-5472]. The appearance of lipoprotein lipase preceded DNA synthesis and post-confluent mitoses which were both putrescine-dependent and which took place before the appearance of glycerol-3-phosphate dehydrogenase. Thus the adipose conversion of Ob1754 cells involves the expression of at least two separate sets of markers which are differently regulated. Images Fig. 3. Fig. 6. PMID:3800927

  9. Inferencias sobre Grafos

    OpenAIRE

    Sira M. Allende; Carlos N. Bouza

    2002-01-01

    El estudio de un juego puede ser modelado asumiendo que solo algunas partidas son observadas. Entonces el árbol del juego debe ser estimado utilizando información muestral. Similarmente ocurre al obtener información sobre el comportamiento de las decisiones tomadas por individuos muestreados sobre un árbol de decisión teórico. Al considerar una medida de probabilidad que caracterice el comportamiento de redes aleatorias se puede obtener un estimado del árbol asociado. Este problema es el anal...

  10. Sobre software libre

    OpenAIRE

    Matellán Olivera, Vicente; González Barahona, Jesús; Heras Quirós, Pedro de las; Robles Martínez, Gregorio

    2004-01-01

    220 p. "Sobre software libre" reune casi una treintena de ensayos sobre temas de candente actualidad relacionados con el software libre (del cual Linux es su ex- ponente más conocido). Los ensayos que el lector encontrará están divididos en bloques temáticos que van desde la propiedad intelectual o las cuestiones económicas y sociales de este modelo hasta su uso en la educación y las administraciones publicas, pasando por alguno que repasa la historia del software libre en l...

  11. EVIDENCE FOR DELAYED MASSIVE STAR FORMATION IN THE M17 PROTO-OB ASSOCIATION

    International Nuclear Information System (INIS)

    Povich, Matthew S.; Whitney, Barbara A.

    2010-01-01

    Through analysis of archival images and photometry from the Spitzer GLIMPSE and MIPSGAL surveys combined with Two Micron All Sky Survey and MSX data, we have identified 488 candidate young stellar objects (YSOs) in the giant molecular cloud M17 SWex, which extends ∼50 pc southwest from the prominent Galactic H II region M17. Our sample includes >200 YSOs with masses >3 M sun that will become B-type stars on the main sequence. Extrapolating over the stellar initial mass function (IMF), we find that M17 SWex contains >1.3 x 10 4 young stars, representing a proto-OB association. The YSO mass function is significantly steeper than the Salpeter IMF, and early O stars are conspicuously absent from M17 SWex. Assuming M17 SWex will form an OB association with a Salpeter IMF, these results reveal the combined effects of (1) more rapid circumstellar disk evolution in more massive YSOs and (2) delayed onset of massive star formation.

  12. La binaria LSS 3074 y su entorno: ?`una nueva asociación OB?

    Science.gov (United States)

    Niemela, V.; Morrell, N.; Corti, M.

    En este trabajo presentamos un nuevo análisis orbital de LSS~3074, junto con tipos espectrales y velocidades radiales de estrellas que podrían constituir con ella una nueva asociación OB. La estrella O4f LSS3074 fue descubierta como binaria espectroscópica de corto período y líneas dobles por Morrell & Niemela (1990, ASP Conf. Ser. 7, 57). Posteriormente, Haefner et~al.(1994, IBVS 3969) encontraron variaciones fotométricas, estimando una inclinación orbital entre 50o y 55o. Teniendo en cuenta la importancia de obtener valores empíricos para las masas de estrellas O tempranas, y considerando la gran dispersión existente entre los valores observados y su discrepancia con los predichos por los modelos teóricos, hemos obtenido nuevas observaciones espectroscópicas de este sistema, con el propósito de mejorar los elementos orbitales derivados en la solución preliminar. Además, como las estrellas O tempranas suelen formar parte de cúmulos y asociaciones OB, hemos llevado a cabo una investigación espectroscópica de varias estrellas tempranas que podrían estar físicamente relacionadas con LSS~3074.

  13. Hard X-ray Flux from Low-Mass Stars in the Cygnus OB2 Association

    Science.gov (United States)

    Caramazza, M.; Drake, J. J.; Micela, G.; Flaccomio, E.

    2009-05-01

    We investigate the X-ray emission in the 20-40 keV band expected from the flaring low-mass stellar population in Cygnus OB2 assuming that the observed soft X-ray emission is due to a superposition of flares and that the ratio of hard X-ray to soft X-ray emission is described by a scaling found for solar flares by Isola and co-workers. We estimate a low-mass stellar hard X-ray flux in the 20-40 keV band in the range ~7×1031-7×1033 erg/s and speculate the limit of this values. Hard X-ray emission could lie at a level not much below the current observed flux upper limits for Cygnus OB2. Simbol-X, with its broad energy band (10-100 keV) and its sensitivity should be able to detect this emission and would provide insights into the hard X-ray production of flares on pre-main sequence stars.

  14. Into the Darkness: Interstellar Extinction Near the Cepheus OB3 Molecular Cloud

    Science.gov (United States)

    Fitzpatrick, Edward L.; Jacklin, S.; Massa, D.

    2014-01-01

    We present the results of a followup investigation to a study performed by Massa and Savage (1984, ApJ, 279, 310) of the properties of UV interstellar extinction in the region of the Cepheus OB3 molecular cloud. That study was performed using UV photometry and spectro-photometry from the ANS and IUE satellites. We have extended this study into the IR, utilizing the uniform database of IR photometry available from the 2MASS project. This is a part of a larger program whose goal is to study the properties of extinction in localized regions, where we hope to find clues to dust grain growth and destruction processes through spatial correlations of extinction with distinct environmental properties. Similarly to Massa and Savage’s UV results, we find that the IR extinction properties on the Cepheus OB3 region vary systematically with the apparent proximity of the target stars to the molecular cloud. We also find that the UV extinction and the IR extinction are crudely correlated. The methodology leading to these results and their implications are discussed.

  15. OB Stars and Cepheids From the Gaia TGAS Catalogue: Test of their Distances and Proper Motions

    Directory of Open Access Journals (Sweden)

    Bobylev Vadim V.

    2017-12-01

    Full Text Available We consider young distant stars from the Gaia TGAS catalog. These are 250 classical Cepheids and 244 OB stars located at distances up to 4 kpc from the Sun. These stars are used to determine the Galactic rotation parameters using both trigonometric parallaxes and proper motions of the TGAS stars. In this case the considered stars have relative parallax errors less than 200%. Following the well-known statistical approach, we assume that the kinematic parameters found from the line-of-sight velocities Vr are less dependent on errors of distances than the found from the velocity components Vl. From values of the first derivative of the Galactic rotation angular velocity ′0, found from the analysis of velocities Vr and Vl separately, the scale factor of distances is determined.We found that from the sample of Cepheids the scale of distances of the TGAS should be reduced by 3%, and from the sample of OB stars, on the contrary, the scale should be increased by 9%.

  16. A CANDIDATE FOR THE MOST LUMINOUS OB ASSOCIATION IN THE GALAXY

    International Nuclear Information System (INIS)

    Rahman, Mubdi; Matzner, Christopher; Moon, Dae-Sik

    2011-01-01

    The Milky Way harbors giant H II regions, which may be powered by star complexes more luminous than any known Galactic OB association. Being across the disk of the Galaxy, however, these brightest associations are severely extinguished and confused. We present a search for one such association toward the most luminous H II region in the recent catalog by Murray and Rahman, which, at ∼9.7 kpc, has a recombination rate of ∼7 x 10 51 s -1 . Prior searches have identified only small-scale clustering around the rim of this shell-like region, but the primary association has not previously been identified. We apply a near-infrared color selection and find an overdensity of point sources toward its southern central part. The colors and magnitudes of these excess sources are consistent with O- and early B-type stars at extinctions 0.96 K < 1.2, and they are sufficiently numerous (406 ± 102 after subtraction of field sources) to ionize the surrounding H II region, making this a candidate for the most luminous OB association in the Galaxy. We reject an alternate theory, in which the apparent excess is caused by localized extinction, as inconsistent with source demographics.

  17. Analysis of interstellar extinction towards the hypergiant Cyg OB2 No. 12

    Science.gov (United States)

    Maryeva, O. V.; Chentsov, E. L.; Goranskij, V. P.; Karpov, S. V.

    The Cyg OB2 stellar association hosts an entire zoo of unique objects, and among them -- an enigmatic star Cyg OB2 No. 12 (Schulte 12, MT 304). MT 304 is enigmatic not only due to its highest luminosity (according to various estimates, it is one of the brightest stars in the Galaxy), but also because its reddening is anomalously large, greater than the mean reddening in the association. To explain the nature of anomalous reddening (AV≃ 10 mag) of MT 304, we carried out spectrophotometric observations of 25 stars located in its vicinity. We mapped interstellar extinction within the 2.5 arcmin radius and found it to increase towards MT 304. According to our results, the two most reddened stars in the association after MT 304 are J203240.35+411420.1 and J203239.90+411436.2, both located about 15 arcsec from it. Interstellar extinction AV towards these stars is about 9 mag. Our results favor the hypothesis of the circumstellar nature of reddening excess. In the second part of the paper we present the results of our modeling of MT 282 (B1 IV) and MT 343 (B1 V), which belong to the older population of the association and have ages greater than 10 Myr.

  18. The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold

    International Nuclear Information System (INIS)

    Das, Debanu; Kozbial, Piotr; Han, Gye Won; Carlton, Dennis; Jaroszewski, Lukasz; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Bakolitsa, Constantina; Chen, Connie; Chiu, Hsiu-Ju; Chiu, Michelle; Clayton, Thomas; Deller, Marc C.; Duan, Lian; Ellrott, Kyle; Elsliger, Marc-André; Ernst, Dustin; Farr, Carol L.; Feuerhelm, Julie; Grzechnik, Anna; Grant, Joanna C.; Jin, Kevin K.; Johnson, Hope A.; Klock, Heath E.; Knuth, Mark W.; Krishna, S. Sri; Kumar, Abhinav; Marciano, David; McMullan, Daniel; Miller, Mitchell D.; Morse, Andrew T.; Nigoghossian, Edward; Nopakun, Amanda; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Puckett, Christina; Reyes, Ron; Rife, Christopher L.; Sefcovic, Natasha; Tien, Henry J.; Trame, Christine B.; Bedem, Henry van den; Weekes, Dana; Wooten, Tiffany; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

    2009-01-01

    KPN03535 is a protein unique to K. pneumoniae. The crystal structure reveals that KPN03535 represents a novel variant of the OB-fold and is likely to be a DNA-binding lipoprotein. KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB-fold and structurally similar to the bacterial Cpx-pathway protein NlpE, single-stranded DNA-binding (SSB) proteins and toxins. K. pneumoniae MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital-acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB-fold family

  19. Far-infrared and CO observations of Cep F: Implications for star formation in Cepheus OB3

    International Nuclear Information System (INIS)

    Sargent, A.I.; van Duinen, R.J.; Nordh, H.L.; Fridlund, C.V.M.; Aalders, J.W.G.; Beintema, D.

    1983-01-01

    Observations at 80-μm and 130-μm have revealed a source of far-infrared emission in the Cep F portion of the Cepheus OB3 molecular cloud. Molecular line measurements of this region, at the CO J = 1-0 line frequency, have led to the discovery of two CO maxima. One of these coincides with the new far-infrared source. The other is at least as intense as Cep B, until now considered to be the hottest part of the cloud. There is some evidence to suggest that a second far-infrared source is associated with this hotspot. If the far-infrared emission results from the presence of embedded protostars, their location, relative to the OB association stars and to the other active region, Cep A, requires a reexamination of how stars form in the Cepheus OB3 association

  20. Toward Complete Statistics of Massive Binary Stars: Penultimate Results from the Cygnus OB2 Radial Velocity Survey

    OpenAIRE

    Kobulnicky, Henry A.; Kiminki, Daniel C.; Lundquist, Michael J.; Burke, Jamison; Chapman, James; Keller, Erica; Lester, Kathryn; Rolen, Emily K.; Topel, Eric; Bhattacharjee, Anirban; Smullen, Rachel A.; Alvarez, Carlos A. Vargas; Runnoe, Jessie C.; Dale, Daniel A.; Brotherton, Michael M.

    2014-01-01

    We analyze orbital solutions for 48 massive multiple-star systems in the Cygnus OB2 Association, 23 of which are newly presented here, to find that the observed distribution of orbital periods is approximately uniform in log P for P 45 d, even after correction for completeness, indicating either a lower binary fraction or a shift toward low-mass companions. A high degree of similarity (91% likelihood) between the Cyg OB2 period distribution and that of other surveys suggests that the binary p...

  1. Asteroseismology of OB stars with hundreds of single snapshot spectra (and a few time-series of selected targets)

    Science.gov (United States)

    Simón-Díaz, S.

    2015-01-01

    Imagine we could do asteroseismology of large samples of OB-type stars by using just one spectrum per target. That would be great! But this is probably a crazy and stupid idea. Or maybe not. Maybe we have the possibility to open a new window to investigate stellar oscillations in massive stars that has been in front of us for many years, but has not attracted very much our attention: the characterization and understanding of the so-called macroturbulent broadening in OB-type stars.

  2. Optimal Inversion Parameters for Full Waveform Inversion using OBS Data Set

    Science.gov (United States)

    Kim, S.; Chung, W.; Shin, S.; Kim, D.; Lee, D.

    2017-12-01

    In recent years, full Waveform Inversion (FWI) has been the most researched technique in seismic data processing. It uses the residuals between observed and modeled data as an objective function; thereafter, the final subsurface velocity model is generated through a series of iterations meant to minimize the residuals.Research on FWI has expanded from acoustic media to elastic media. In acoustic media, the subsurface property is defined by P-velocity; however, in elastic media, properties are defined by multiple parameters, such as P-velocity, S-velocity, and density. Further, the elastic media can also be defined by Lamé constants, density or impedance PI, SI; consequently, research is being carried out to ascertain the optimal parameters.From results of advanced exploration equipment and Ocean Bottom Seismic (OBS) survey, it is now possible to obtain multi-component seismic data. However, to perform FWI on these data and generate an accurate subsurface model, it is important to determine optimal inversion parameters among (Vp, Vs, ρ), (λ, μ, ρ), and (PI, SI) in elastic media. In this study, staggered grid finite difference method was applied to simulate OBS survey. As in inversion, l2-norm was set as objective function. Further, the accurate computation of gradient direction was performed using the back-propagation technique and its scaling was done using the Pseudo-hessian matrix.In acoustic media, only Vp is used as the inversion parameter. In contrast, various sets of parameters, such as (Vp, Vs, ρ) and (λ, μ, ρ) can be used to define inversion in elastic media. Therefore, it is important to ascertain the parameter that gives the most accurate result for inversion with OBS data set.In this study, we generated Vp and Vs subsurface models by using (λ, μ, ρ) and (Vp, Vs, ρ) as inversion parameters in every iteration, and compared the final two FWI results.This research was supported by the Basic Research Project(17-3312) of the Korea Institute of

  3. Variable millimetre radiation from the colliding-wind binary Cygnus OB2 #8A

    Science.gov (United States)

    Blomme, R.; Fenech, D. M.; Prinja, R. K.; Pittard, J. M.; Morford, J. C.

    2017-12-01

    Context. Massive binaries have stellar winds that collide. In the colliding-wind region, various physically interesting processes occur, leading to enhanced X-ray emission, non-thermal radio emission, as well as non-thermal X-rays and gamma-rays. Non-thermal radio emission (due to synchrotron radiation) has so far been observed at centimetre wavelengths. At millimetre wavelengths, the stellar winds and the colliding-wind region emit more thermal free-free radiation, and it is expected that any non-thermal contribution will be difficult or impossible to detect. Aims: We aim to determine if the material in the colliding-wind region contributes substantially to the observed millimetre fluxes of a colliding-wind binary. We also try to distinguish the synchrotron emission from the free-free emission. Methods: We monitored the massive binary Cyg OB2 #8A at 3 mm with the NOrthern Extended Millimeter Array (NOEMA) interferometer of the Institut de Radioastronomie Millimétrique (IRAM). The data were collected in 14 separate observing runs (in 2014 and 2016), and provide good coverage of the orbital period. Results: The observed millimetre fluxes range between 1.1 and 2.3 mJy, and show phase-locked variability, clearly indicating that a large part of the emission is due to the colliding-wind region. A simple synchrotron model gives fluxes with the correct order of magnitude, but with a maximum that is phase-shifted with respect to the observations. Qualitatively this phase shift can be explained by our neglect of orbital motion on the shape of the colliding-wind region. A model using only free-free emission results in only a slightly worse explanation of the observations. Additionally, on the map of our observations we also detect the O6.5 III star Cyg OB2 #8B, for which we determine a 3 mm flux of 0.21 ± 0.033 mJy. Conclusions: The question of whether synchrotron radiation or free-free emission dominates the millimetre fluxes of Cyg OB2 #8A remains open. More detailed

  4. ObsPy: Establishing and maintaining an open-source community package

    Science.gov (United States)

    Krischer, L.; Megies, T.; Barsch, R.

    2017-12-01

    Python's ecosystem evolved into one of the most powerful and productive research environment across disciplines. ObsPy (https://obspy.org) is a fully community driven, open-source project dedicated to provide a bridge for seismology into that ecosystem. It does so by offering Read and write support for essentially every commonly used data format in seismology, Integrated access to the largest data centers, web services, and real-time data streams, A powerful signal processing toolbox tuned to the specific needs of seismologists, and Utility functionality like travel time calculations, geodetic functions, and data visualizations. ObsPy has been in constant unfunded development for more than eight years and is developed and used by scientists around the world with successful applications in all branches of seismology. By now around 70 people directly contributed code to ObsPy and we aim to make it a self-sustaining community project.This contributions focusses on several meta aspects of open-source software in science, in particular how we experienced them. During the panel we would like to discuss obvious questions like long-term sustainability with very limited to no funding, insufficient computer science training in many sciences, and gaining hard scientific credits for software development, but also the following questions: How to best deal with the fact that a lot of scientific software is very specialized thus usually solves a complex problem but at the same time can only ever reach a limited pool of developers and users by virtue of it being so specialized? Therefore the "many eyes on the code" approach to develop and improve open-source software only applies in a limited fashion. An initial publication for a significant new scientific software package is fairly straightforward. How to on-board and motivate potential new contributors when they can no longer be lured by a potential co-authorship? When is spending significant time and effort on reusable

  5. MODELING THE RADIO EMISSION FROM Cyg OB2 NO. 5: A QUADRUPLE SYSTEM?

    International Nuclear Information System (INIS)

    Kennedy, M.; Dougherty, S. M.; Fink, A.; Williams, P. M.

    2010-01-01

    Fifty observations at frequencies between 1.4 GHz and 43 GHz of the 6.6 day O6.5-7+O5.5-6 binary Cyg OB2 No. 5 using the Very Large Array over 20 years are re-examined. The aim is to determine the location and character of the previously detected variable radio emission. The radio emission from the system consists of a primary component that is associated with the binary, and a non-thermal source (NE), 0.''8 to the NE of the binary that has been ascribed to a wind-collision region (WCR) between the stellar winds of the binary and that of a B-type star (Star D) to the NE. Previous studies have not accounted for the potential contribution of NE to the total radio emission, most especially in observations where the primary and NE sources are not resolved as separate sources. NE shows no evidence of variation in 23 epochs where it is resolved separately from the primary radio component, demonstrating that the variable emission arises in the primary component. Since NE is non-variable, the radio flux from the primary can now be well determined for the first time, most especially in observations that do not resolve both the primary and NE components. The variable radio emission from the primary component has a period of 6.7 ± 0.3 years which is described by a simple model of a non-thermal source orbiting within the stellar wind envelope of the binary. Such a model implies the presence of a third, unresolved stellar companion (Star C) orbiting the 6.6 day binary with a period of 6.7 years and independent of Star D to the NE. The variable non-thermal emission arises from either a WCR between Star C and the binary system, or possibly from Star C directly. The model gives a mass-loss rate of 3.4 x 10 -5 M sun yr -1 for Cyg OB2 No. 5, unusually high for an Of supergiant and comparable to that of WR stars, and consistent with an unusually strong He I 1.083 μm emission line, also redolent of WR stars. An examination of radial velocity observations available from the

  6. A survey of formaldehyde in the Cepheus OB3 molecular cloud

    International Nuclear Information System (INIS)

    Few, R.W.; Cohen, R.J.

    1983-01-01

    The 1 11 - 1 10 absorption line of formaldehyde at 6-cm wavelength has been surveyed over the region of the Cepheus OB3 molecular cloud, using the Jodrell Bank Mk II radio telescope (beamwidth 9 x 10 arcmin 2 ). The measurements have a velocity resolution of 0.27 km s - 1 and an rms noise level of approx. 0.01 K. The formaldehyde has a very clumpy distribution which is broadly similar to the CO distribution found by Sargent. A total molecular mass of 1.9 x 10 4 solar masses is implied by the formaldehyde measurements. Cepheus A is not the dominant concentration in the formaldehyde map. The most massive formaldehyde concentration is Cepheus C, which has a mass of 3600 solar masses. It appears to be stabilized by rotation. (author)

  7. New Partner Recruitment to Rural Versus Urban Ob-Gyn Practices

    Directory of Open Access Journals (Sweden)

    Michael F. Fialkow

    2017-09-01

    Full Text Available Purpose: The purpose of this pilot study was to investigate the recruitment efforts of practicing obstetrics and gynecology (ob-gyns from rural and urban practices. Method: The authors surveyed practicing ob-gyns from 5 states in the Pacific Northwest in 2016 about their background, practice setting, practice profile, partner recruitment, and retention. Results: Seventy-three patients completed the study (53.2% response rate. Thirty-seven percent of respondents work in an urban practice and 43% have a rural practice, with the remainder in a suburban setting. A majority of the respondents attempted to recruit a new partner in the past 5 years. Respondents were most interested in experience and diversity in new recruits. Urban respondents, however, were more interested in hiring those with specialized skills (χ 2 = 7.842, P = .02 than rural providers who were more interested in partners familiar with their community (χ 2 = 7.153, P = .03. Reasons most often cited to leave their practice were reimbursement, limited social/marital options, and workload, other than rural providers who more often also cited lack of access to specialty care (χ 2 = 13.256, P = .001. Rural providers were more likely to cite marital and family status as an advantage to recruitment, whereas urban and suburban providers were more often neutral. Conclusions: Reduced access to care has led to significant health disparities for women living in rural communities. Understanding which providers are most likely to be successful in these settings might help preserve access as our health-care systems evolves.

  8. SCUBA and HIRES Results for Protostellar Cores in the MON OB1 Dark Cloud

    Science.gov (United States)

    Wolf-Chase, G.; Moriarty-Schieven, G.; Fich, M.; Barsony, M.

    1999-05-01

    We have used HIRES-processing of IRAS data and point-source modelling techniques (Hurt & Barsony 1996; O'Linger 1997; Barsony et al. 1998), together with submillimeter continuum imaging using the Submillimeter Common-User Bolometer Array (SCUBA) on the 15-meter James Clerk Maxwell Telescope (JCMT), to search CS cores in the Mon OB1 dark cloud (Wolf-Chase, Walker, & Lada 1995; Wolf-Chase & Walker 1995) for deeply embedded sources. These observations, as well as follow-up millimeter photometry at the National Radio Astronomy Observatory (NRAO) 12-meter telescope on Kitt Peak, have lead to the identification of two Class 0 protostellar candidates, which were previously unresolved from two brighter IRAS point sources (IRAS 06382+0939 & IRAS 06381+1039) in this cloud. Until now, only one Class 0 object had been confirmed in Mon OB1; the driving source of the highly-collimated outflow NGC 2264 G (Ward-Thompson, Eiroa, & Casali 1995; Margulis et al. 1990; Lada & Fich 1996), which lies well outside the extended CS cores. One of the new Class 0 candidates may be an intermediate-mass source associated with an H_2O maser, and the other object is a low-mass source which may be associated with a near-infrared jet, and possibly with a molecular outflow. We report accurate positions for the new Class 0 candidates, based on the SCUBA images, and present new SEDs for these sources, as well as for the brighter IRAS point sources. A portion of this work was performed while GWC held a President's Fellowship from the University of California. MB and GWC gratefully acknowledge financial support from MB's NSF CAREER Grant, AST97-9753229.

  9. Inferencias sobre Grafos

    Directory of Open Access Journals (Sweden)

    Sira M. Allende

    2002-05-01

    Full Text Available El estudio de un juego puede ser modelado asumiendo que solo algunas partidas son observadas. Entonces el árbol del juego debe ser estimado utilizando información muestral. Similarmente ocurre al obtener información sobre el comportamiento de las decisiones tomadas por individuos muestreados sobre un árbol de decisión teórico. Al considerar una medida de probabilidad que caracterice el comportamiento de redes aleatorias se puede obtener un estimado del árbol asociado. Este problema es el analizado en este trabajo. Algunos resultados experimentales obtenidos usando Recocido Simulado ilustran el procedimiento. Su papel en el estudio de modelos económicos y de mercadeo es discutido.

  10. Escrito sobre el cuerpo

    Directory of Open Access Journals (Sweden)

    Antonio Malalana Ureña

    2013-09-01

    Full Text Available El catálogo, en una edición bilingüe español-inglés, es una pequeña guía de la exposición Shirin Neshat. Escrito sobre el cuerpo, muestra que se integra dentro de los actos de PHOTOESPAÑA13, el festival internacional de fotografía y artes visuales. El esquema del libro es sencillo y los textos son extremadamente divulgativos. El primero de ellos, Escrito sobre el cuerpo (pp. 10-15, cuyo autor es Octavio Zaya, comisario de la exposición, resume la trayectoria de esta intelectual, que "interactúa" con la fotografía y los formatos audiovisuales, y nos presenta la argumentación narrativa de los documentos expuestos, contextualizando la obra recopilada.

  11. Evaluating the probiotic and therapeutic potentials of Saccharomyces cerevisiae strain (OBS2) isolated from fermented nectar of toddy palm.

    Science.gov (United States)

    Srinivas, Banoth; Rani, Ganapathiwar Swarupa; Kumar, Bhukya Kiran; Chandrasekhar, Banoth; Krishna, Kommalapati Vamsi; Devi, Tangutur Anjana; Bhima, Bhukya

    2017-12-01

    The purpose of this study is to evaluate the probiotic characteristics of 15 yeast strains isolated from nectar of toddy palm. Initially, the collected samples were inoculated on yeast extract peptone dextrose agar plates and the colonies so obtained were culturally and morphologically characterized. Commercial probiotic yeast, Saccharomyces boulardii served as the control in these experiments. Of the 15 yeast strains, the isolates that were resistant to antibiotics and worked synergistically with other cultures were considered for further evaluation. Selected isolates were evaluated in vitro for tolerance to simulated gastrointestinal conditions such as temperature, pH, bile and gastric juice. Further the yeast isolates were evaluated for their pathogenicity and adherence to intestinal epithelial cells. The 2 yeast isolates with efficient probiotic properties were finally characterized by sequencing their 5.8 S rRNA and partial sequences of internal transcribed spacer 1 and 2. The sequences were BLAST searched in the National Center for Biotechnology Information, nucleic acid database for sequence similarity of organisms and phylogenetic evolutionary analysis was carried out. Based on maximum similarity of basic local alignment search tool results, organisms were characterized as Pichia kudriavzevii OBS1 (100%) and Saccharomyces cerevisiae OBS2 (96%) and sequences were finally deposited in the GenBank data library. Among these two isolates, S. cerevisiae OBS2 displayed slight/moderate antioxidant and anticancer property. Hence, strain OBS2 can be utilized and explored as a potential probiotic for therapeutic applications.

  12. Attenuation of S-waves in the lithosphere of the Sea of Crete according to OBS observations

    Science.gov (United States)

    Kovachev, S. A.; Kuzin, I. P.; Shoda, O. Yu.; Soloviev, S. L.

    1991-11-01

    Five OBS were installed in the Sea of Crete in 1987. During a period of nine days 430 local earthquakes were recorded. Hypocentres were determined for 85 microearthquakes. A correlation between magnitude ML and duration of seismic events on the records of the ocean bottom seismographs (OBS) was found from data of 14 shocks recorded simultaneously by OBS and some land-based Greek stations. A magnitude-frequency relationship for earthquakes recorded by OBS was obtained in the magnitude range ML = 2-4. Amplitude curves describing the attenuation of body waves in the lithosphere of the Sea of Crete were compiled. Assessment of quality factor Qs was made by comparison of empirical and theoretical amplitude curves. The values of Qs for the lithosphere of the Sea of Crete were calculated and found equal to 200-300. Low values of Qs and consequently strong attenuation of S-waves in the lithosphere of the Sea of Crete could be explained by extension of the lithosphere accompanied by its partial contamination with melted magma.

  13. Lutter contre l'obésité en Afrique du Sud à l'aide des politiques fiscales

    International Development Research Centre (IDRC) Digital Library (Canada)

    17 nov. 2016 ... En 2008, le fardeau total des maladies non transmissibles en Afrique du Sud était estimé à 40 %, et ne cessait de croître. L'obésité est un facteur de risque de plusieurs maladies non transmissibles, dont les cardiopathies, l'hypertension, le diabète et le cancer.

  14. B fields in OB stars (BOB): Low-resolution FORS2 spectropolarimetry of the first sample of 50 massive stars

    NARCIS (Netherlands)

    Fossati, L.; Castro, N.; Schöller, M.; Hubrig, S.; Langer, N.; Morel, T.; Briquet, M.; Herrero, A.; Przybilla, N.; Sana, H.; Schneider, F.R.N.; de Koter, A.

    2015-01-01

    Within the context of the collaboration "B fields in OB stars" (BOB), we used the FORS2 low-resolution spectropolarimeter to search for a magnetic field in 50 massive stars, including two reference magnetic massive stars. Because of the many controversies of magnetic field detections obtained with

  15. Case Study of Data Mining in Observational Astronomy: The Search for New OB Stars in the Small Magellanic Cloud

    Science.gov (United States)

    Larkin, Cormac; Vink, Jorick; Kalari, Venu; Groh, Jose

    2018-01-01

    OB stars are the most luminous and massive stars, living short lives and exerting a disproportionate influence on their environments. They are key to understanding progenitors of gravitational wave sources and reionization of the early Universe. To detect new OB stars, we combine photometric catalog data with TLUSTY and ATLAS9 stellar atmospheres. This method is also believed to be sensitive to elusive “stripped” stars, thought to lose their hydrogen envelope through binary interaction.OB stars are intrinsically luminous, so complete populations are assumed for local group galaxies such as the Small Magellanic Cloud. Our findings challenge this, as we find 26 new OB candidates. Spectroscopy of 7 candidates shows a 100% detection rate. Most interestingly, 5 of our candidates are consistent with “stripped” stars.To date only 5 “stripped” candidates have been found serendipitously (e.g. HD 45166) as current methods are not sensitive to them. Our work doubles the sample of detected candidates, highlighting that our approach is the first to identify them in a targeted, systematic way. The finding of “stripped” stars could rewrite our understanding of the early Universe, offering an alternative hypothesis to Wolf-Rayet driven cosmic reionization.

  16. Structure-guided mutational analysis of the OB, HhH, and BRCT domains of Escherichia coli DNA ligase.

    Science.gov (United States)

    Wang, Li Kai; Nair, Pravin A; Shuman, Stewart

    2008-08-22

    NAD(+)-dependent DNA ligases (LigAs) are ubiquitous in bacteria and essential for growth. LigA enzymes have a modular structure in which a central catalytic core composed of nucleotidyltransferase and oligonucleotide-binding (OB) domains is linked via a tetracysteine zinc finger to distal helix-hairpin-helix (HhH) and BRCT (BRCA1-like C-terminal) domains. The OB and HhH domains contribute prominently to the protein clamp formed by LigA around nicked duplex DNA. Here we conducted a structure-function analysis of the OB and HhH domains of Escherichia coli LigA by alanine scanning and conservative substitutions, entailing 43 mutations at 22 amino acids. We thereby identified essential functional groups in the OB domain that engage the DNA phosphodiester backbone flanking the nick (Arg(333)); penetrate the minor grove and distort the nick (Val(383) and Ile(384)); or stabilize the OB fold (Arg(379)). The essential constituents of the HhH domain include: four glycines (Gly(455), Gly(489), Gly(521), Gly(553)), which bind the phosphate backbone across the minor groove at the outer margins of the LigA-DNA interface; Arg(487), which penetrates the minor groove at the outer margin on the 3 (R)-OH side of the nick; and Arg(446), which promotes protein clamp formation via contacts to the nucleotidyltransferase domain. We find that the BRCT domain is required in its entirety for effective nick sealing and AMP-dependent supercoil relaxation.

  17. Methanobactin from Methylocystis sp. strain SB2 affects gene expression and methane monooxygenase activity in Methylosinus trichosporium OB3b.

    Science.gov (United States)

    Farhan Ul-Haque, Muhammad; Kalidass, Bhagyalakshmi; Vorobev, Alexey; Baral, Bipin S; DiSpirito, Alan A; Semrau, Jeremy D

    2015-04-01

    Methanotrophs can express a cytoplasmic (soluble) methane monooxygenase (sMMO) or membrane-bound (particulate) methane monooxygenase (pMMO). Expression of these MMOs is strongly regulated by the availability of copper. Many methanotrophs have been found to synthesize a novel compound, methanobactin (Mb), that is responsible for the uptake of copper, and methanobactin produced by Methylosinus trichosporium OB3b plays a key role in controlling expression of MMO genes in this strain. As all known forms of methanobactin are structurally similar, it was hypothesized that methanobactin from one methanotroph may alter gene expression in another. When Methylosinus trichosporium OB3b was grown in the presence of 1 μM CuCl2, expression of mmoX, encoding a subunit of the hydroxylase component of sMMO, was very low. mmoX expression increased, however, when methanobactin from Methylocystis sp. strain SB2 (SB2-Mb) was added, as did whole-cell sMMO activity, but there was no significant change in the amount of copper associated with M. trichosporium OB3b. If M. trichosporium OB3b was grown in the absence of CuCl2, the mmoX expression level was high but decreased by several orders of magnitude if copper prebound to SB2-Mb (Cu-SB2-Mb) was added, and biomass-associated copper was increased. Exposure of Methylosinus trichosporium OB3b to SB2-Mb had no effect on expression of mbnA, encoding the polypeptide precursor of methanobactin in either the presence or absence of CuCl2. mbnA expression, however, was reduced when Cu-SB2-Mb was added in both the absence and presence of CuCl2. These data suggest that methanobactin acts as a general signaling molecule in methanotrophs and that methanobactin "piracy" may be commonplace. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  18. Terraplenes sobre suelos colapsables

    OpenAIRE

    Arnedo Gaute, Diego

    2004-01-01

    Esta tesina está motivada por el diseño y construcción del Canal Segarra-Garrigues. El trazado del canal atraviesa varios pequeños valles de fondo llano mediante terraplenes sobre los cuales circula el canal. En estas vaguadas se encuentran suelos limo-arcillosos de baja densidad cuya potencia puede llegar a ser de varios metros. Estos materiales, debido a su estructura abierta, son potencialmente colapsables una vez cargados si experimentan incrementos de humedad. Las deformacion...

  19. DISCUTINDO SOBRE SEXTING

    Directory of Open Access Journals (Sweden)

    Suzana da Conceição de Barros

    2013-07-01

    Full Text Available Na contemporaneidade, os sujeitos vêm se utilizando das diversas tecnologias digitais, para exporem e compartilharem sua intimidade, com intuito de seduzirem e tornarem-se visíveis. Esse fenômeno vem sendo chamado de sexting, e vem sendo aderido por sujeitos de várias faixas etárias. Assim, leitor/a, convido você a pensar sobre o sexting e o que a escola tem a ver com essa prática?

  20. Excertos sobre o sedentarismo

    OpenAIRE

    Palma,Alexandre; Vilaça,Murilo Mariano; Assis,Monique Ribeiro de

    2014-01-01

    O sedentarismo tem sido tratado como algo perfeitamente determinável, objetivo e, portanto, que pode ser apreendido. Por outro lado, o conceito de sedentarismo ainda permanece questionável e, por conseguinte, os instrumentos mostram-se inconsistentes. Neste sentido, o objetivo do presente estudo foi mostrar que diferentes discursos de verdade vêm concorrendo por esse conceito, o que nos motiva a pensar qual é a verdade ou, até mesmo, se há alguma verdade sobre ele. Após apresentarmos diferent...

  1. Constraining formation of the Eggvin Bank (West of Jan Mayen, N. Atlantic) from OBS data

    Science.gov (United States)

    Tan, P.; Breivik, A. J.; Mjelde, R.; Azuma, R.

    2015-12-01

    The anomalously high magma flux in the Eggvin Bank area has triggered new research efforts to better understand the crustal development in this area. The Eggvin Bank is located between the Jan Mayen Island and the west coast of Greenland. Some proposed origins of the Eggvin Bank are: a distinct plume located beneath Jan Mayen; an extension of the Iceland plume; minor spreading or leakage along West Jan Mayen Fracture Zone (WJMFZ); intruded continental crust extending from Jan Mayen Microcontinent (JMMC); and rifted Greenland sub-continental lithospheric mantle. In this first modern refraction seismic study of the Eggvin Bank, we present a 2D velocity model based on OBS data. The OBSs were deployed approx. N-S over the Eggvin Bank with good data quality constrained by 4 OBSs. The air-gun array used during OBS shooting produced good quality reflection data. Three distinct seamounts are observed along the profile: the northern seamount (water depth 730m), has a flat top with a thin sedimentary veneer on top, which indicates it has been eroded at sea surface; while the southern two seamounts, one (water depth 550m) is less flat with around 100m thick sedimentary units on top, another one is rounded with tiny sedimentary veneer on top having the shallowest water depth (460m). This could suggest that the southern seamounts are younger, since they are shallower but without obvious signs that they were subaerially exposed. However, increased cooling of the lithosphere across the WJMFZ in the north may also contribute to depth differences. A normal fault offsetting sedimentary strata (~300 m) in the Greenland Basin indicates recent tectonic activity north of the Eggvin Bank. The velocity modeling shows crustal thickness with large variations, ranging from 8 km to 14 km, where crustal thickness changes of 4-5 km are associated with 20-30 km wide segments with thick crust under the seamounts. The crust consists of three oceanic crustal layers: upper crust (2.8km/s-4.8km

  2. Plutonium speciation and isotope ratios in Yenisey and Ob river and Yenisey estuary

    International Nuclear Information System (INIS)

    Skipperud, L.; Oughton, DH.; Fifield, K.; Lind, O.C.; Salbu, B.; Brown, J.

    2004-01-01

    Plutonium isotope ratios are known to vary with reactor type, nuclear fuel-burn up time, neutron flux, and energy, and for fallout from nuclear detonations, weapon type and yield. Weapons-grade plutonium is characterized by a low content of the 240 Pu isotope, with 240 Pu/ 239 Pu isotope ratio less than 0.05. In contrast, both global weapons fallout and spent nuclear fuel from civil reactors have higher 240 Pu/ 239 Pu isotope ratios (civil nuclear power reactors have 240 Pu/ 239 Pu atom ratios of between about 0.2-1). Thus, different sources often exhibit characteristic plutonium isotope ratios and these ratios can be used to identify the origin of contamination, calculate inventories, or follow the migration of contaminated sediments and waters. Together with activity measurements and isotope ratios, knowledge of plutonium speciation in the Ob and Yenisey rivers and processes controlling its behaviour in estuarine systems is a prerequisite for predicting the transfer and subsequent environmental impact to Arctic Seas. With this in mind, the study had two objectives: first to determine whether discharges from nuclear installations in the river catchment areas are having any influence on Pu levels in the estuaries; and, second, to investigate the transfer and mobility of plutonium in the Yenisey river and estuary. Plutonium 240/239 ratios were determined using accelerator mass spectrometry (AMS). The data indicated a clear influence from a low 240 Pu: 239 Pu source in surface sediments collected from the Yenisey Estuary, whereas plutonium in the Ob Estuary sediments are dominated by global fallout. The results also show an increase in plutonium concentration and a decrease in isotope ratio going upstream from the estuary. Sequential extractions of sediments indicate that up 70% of the Pu in the Yenisey river is easily mobilized with weak oxidizing agents, which indicates that the Pu is organically bound, while the Pu is more strongly irreversible bound further out

  3. Sobre historia mundial hoy

    Directory of Open Access Journals (Sweden)

    Vera Weiler

    2001-01-01

    Full Text Available Los procesos de globalización son una realidad; su enorme impacto sobre la vida humana los ha convertido en un tema recurrente sobre el que se escribe y se comenta a diario también en Colombia. Los libros que de ellos tratan, ante todo los que 10 hacen en tono crítico, baten records en la industria editorial en todo el mundo. Las expectativas que acerca del futuro abrigan cientos de millones de personas se relacionan con 10 que ellas esperan, para bien o para mal, de la globalización. Las posturas que los gobernantes ocupan al respecto en el mundo son, cuando menos de aceptación, generalmente de activa participación en pos de la globalización. Por un lado, crece la preocupación y se multiplican las protestas; por el otro, dominan los razonamientos de los especialistas en materia de maximización de los rendimientos de los capitales que presentan la globalización, al estilo que se viene imponiendo, como el camino ineludible del gobierno universal de la eficiencia. ¿Tienen que decir algo los historiadores frente a todo esto?.

  4. A Deuteration Survey of Starless Clumps in GemOB1 and the First Quadrant

    Science.gov (United States)

    Henrici, Andrew; Shirley, Yancy L.; Svoboda, Brian

    2018-01-01

    One very strong chemical process in star-forming regions is the fractionation of deuterium in molecules, which results in an increase in the deuterium ratio many orders of magnitude over the ISM [D]/[H] ratio and provides a chemical probe of cold, dense regions. Recent maps of dust continuum emission at (sub)millimeter wavelengths have identified tens of thousands of dense clumps of gas and dust. By comparing these regions to infrared and radio surveys, we have identified starless clump candidates which have no evidence for embedded star formation. These objects represent the earliest phase of star formation throughout the Milky Way. One benefit of the Milky Way surveys is that it is also possible to study the chemistry of entire core and clump populations within a single cloud. We used the 10m Heinrich Hertz Submillimeter Telescope to survey starless clump candidates in the First Quadrant identified from the Bolocam Galactic Plane Survey 1.1 mm continuum in the deuterated molecular transitions of DCO+ 3-2 and N2D+ 3-2. We also survey the entire clump population of the Gemini OB1 molecular cloud. In both surveys, we compared detection statistics and compare deuteration fraction to physical properties of the clumps and their evolutionary stage. High resolution ALMA observations of 9 starless clump candidates of the same lines are used to analyze how the cold deuterated gas is spatially distributed in these clumps.

  5. New Version of SeismicHandler (SHX) based on ObsPy

    Science.gov (United States)

    Stammler, Klaus; Walther, Marcus

    2016-04-01

    The command line version of SeismicHandler (SH), a scientific analysis tool for seismic waveform data developed around 1990, has been redesigned in the recent years, based on a project funded by the Deutsche Forschungsgemeinschaft (DFG). The aim was to address new data access techniques, simplified metadata handling and a modularized software design. As a result the program was rewritten in Python in its main parts, taking advantage of simplicity of this script language and its variety of well developed software libraries, including ObsPy. SHX provides an easy access to waveforms and metadata via arclink and FDSN webservice protocols, also access to event catalogs is implemented. With single commands whole networks or stations within a certain area may be read in, the metadata are retrieved from the servers and stored in a local database. For data processing the large set of SH commands is available, as well as the SH scripting language. Via this SH language scripts or additional Python modules the command set of SHX is easily extendable. The program is open source, tested on Linux operating systems, documentation and download is found at URL "https://www.seismic-handler.org/".

  6. Targeting the OB-Folds of Replication Protein A with Small Molecules

    Directory of Open Access Journals (Sweden)

    Victor J. Anciano Granadillo

    2010-01-01

    Full Text Available Replication protein A (RPA is the main eukaryotic single-strand (ss DNA-binding protein involved in DNA replication and repair. We have identified and developed two classes of small molecule inhibitors (SMIs that show in vitro inhibition of the RPA-DNA interaction. We present further characterization of these SMIs with respect to their target binding, mechanism of action, and specificity. Both reversible and irreversible modes of inhibition are observed for the different classes of SMIs with one class found to specifically interact with DNA-binding domains A and B (DBD-A/B of RPA. In comparison with other oligonucleotide/oligosaccharide binding-fold (OB-fold containing ssDNA-binding proteins, one class of SMIs displayed specificity for the RPA protein. Together these data demonstrate that the specific targeting of a protein-DNA interaction can be exploited towards interrogating the cellular activity of RPA as well as increasing the efficacy of DNA-damaging chemotherapeutics used in cancer treatment.

  7. Measurement of Circumstellar Disk Sizes in the Upper Scorpius OB Association with ALMA

    Science.gov (United States)

    Barenfeld, Scott A.; Carpenter, John M.; Sargent, Anneila I.; Isella, Andrea; Ricci, Luca

    2017-12-01

    We present detailed modeling of the spatial distributions of gas and dust in 57 circumstellar disks in the Upper Scorpius OB Association observed with ALMA at submillimeter wavelengths. We fit power-law models to the dust surface density and CO J = 3–2 surface brightness to measure the radial extent of dust and gas in these disks. We found that these disks are extremely compact: the 25 highest signal-to-noise disks have a median dust outer radius of 21 au, assuming an {R}-1 dust surface density profile. Our lack of CO detections in the majority of our sample is consistent with these small disk sizes assuming the dust and CO share the same spatial distribution. Of seven disks in our sample with well-constrained dust and CO radii, four appear to be more extended in CO, although this may simply be due to the higher optical depth of the CO. Comparison of the Upper Sco results with recent analyses of disks in Taurus, Ophiuchus, and Lupus suggests that the dust disks in Upper Sco may be approximately three times smaller in size than their younger counterparts, although we caution that a more uniform analysis of the data across all regions is needed. We discuss the implications of these results for disk evolution.

  8. SPITZER IRS SPECTRA OF DEBRIS DISKS IN THE SCORPIUS–CENTAURUS OB ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Jang-Condell, Hannah [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); Chen, Christine H.; Mittal, Tushar; Lisse, Carey M. [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); Manoj, P. [Department of Astronomy and Astrophysics, Tata Institute of Fundamental Research, Homi Bhabha Rd., Mumbai 400005 (India); Watson, Dan [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627 (United States); Nesvold, Erika; Kuchner, Marc [NASA Goddard Space Flight Center, Greenbelt, MD (United States)

    2015-08-01

    We analyze spectra obtained with the Spitzer Infrared Spectrograph (IRS) of 110 B-, A-, F-, and G-type stars with optically thin infrared excess in the Scorpius–Centaurus OB association. The ages of these stars range from 11 to 17 Myr. We fit the infrared excesses observed in these sources by Spitzer IRS and the Multiband Imaging Photometer for Spitzer (MIPS) to simple dust models according to Mie theory. We find that nearly all of the objects in our study can be fit by one or two belts of dust. Dust around lower mass stars appears to be closer in than around higher mass stars, particularly for the warm dust component in the two-belt systems, suggesting a mass-dependent evolution of debris disks around young stars. For those objects with stellar companions, all dust distances are consistent with truncation of the debris disk by the binary companion. The gaps between several of the two-belt systems can place limits on the planets that might lie between the belts, potentially constraining the mass and locations of planets that may be forming around these stars.

  9. An ALMA continuum survey of circumstellar disks in the upper Scorpius OB association

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, John M.; Ricci, Luca; Isella, Andrea [Department of Astronomy, California Institute of Technology, MC 249-17, Pasadena, CA 91125 (United States)

    2014-05-20

    We present ALMA 880 μm continuum observations of 20 K- and M-type stars in the Upper Scorpius OB association (Upper Sco) that are surrounded by protoplanetary disks. These data are used to measure the dust content in disks around low-mass stars (0.1-1.6 M {sub ☉}) at a stellar age of 5-11 Myr. Thirteen sources were detected in the 880 μm dust continuum at ≥3σ with inferred dust masses between 0.3 and 52 M {sub ⊕}. The dust masses tend to be higher around the more massive stars, but the significance is marginal in that the probability of no correlation is p ≈ 0.03. The evolution in the dust content in disks was assessed by comparing the Upper Sco observations with published continuum measurements of disks around ∼1-2 Myr stars in the Class II stage in the Taurus molecular cloud. While the dust masses in the Upper Sco disks are on average lower than in Taurus, any difference in the dust mass distributions is significant at less than 3σ. For stellar masses between 0.49 M {sub ☉} and 1.6 M {sub ☉}, the mean dust mass in disks is lower in Upper Sco relative to Taurus by Δlog M {sub dust} = 0.44 ± 0.26.

  10. Central stars of planetary nebulae. II. New OB-type and emission-line stars

    Science.gov (United States)

    Weidmann, W. A.; Gamen, R.

    2011-07-01

    Context. There are more than 3000 confirmed and probably known Galactic planetary nebulae (PNe), but central star spectroscopic information is available for only 13% of them. Aims: We have undertaken a spectroscopic survey of the central stars in PNe to identify their spectral types. Methods: We performed spectroscopic observations at low resolution with the 2-m telescope at CASLEO, Argentina. Results: We present the spectra of 46 central stars of PNe, most of them are OB-type and emission-line stars. Based on data collected at the Complejo Astronómico El Leoncito (CASLEO), which is operated under agreement between the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina y Universidades Nacionales de La Plata, Córdoba y San Juan, Argentina.The reduced spectra (FITS files) are available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/531/A172

  11. DIRECT IMAGING AND SPECTROSCOPY OF A YOUNG EXTRASOLAR KUIPER BELT IN THE NEAREST OB ASSOCIATION

    International Nuclear Information System (INIS)

    Currie, Thayne; Lisse, Carey M.; Kuchner, Marc; Madhusudhan, Nikku; Kenyon, Scott J.; Thalmann, Christian; Carson, Joseph; Debes, John

    2015-01-01

    We describe the discovery of a bright, young Kuiper belt–like debris disk around HD 115600, a ∼1.4–1.5 M ⊙ , ∼15 Myr old member of the Sco–Cen OB Association. Our H-band coronagraphy/integral field spectroscopy from the Gemini Planet Imager shows the ring has a (luminosity-scaled) semimajor axis of (∼22 AU) ∼ 48 AU, similar to the current Kuiper belt. The disk appears to have neutral-scattering dust, is eccentric (e ∼ 0.1–0.2), and could be sculpted by analogs to the outer solar system planets. Spectroscopy of the disk ansae reveal a slightly blue to gray disk color, consistent with major Kuiper belt chemical constituents, where water ice is a very plausible dominant constituent. Besides being the first object discovered with the next generation of extreme adaptive optics systems (i.e., SCExAO, GPI, SPHERE), HD 115600's debris ring and planetary system provide a key reference point for the early evolution of the solar system, the structure, and composition of the Kuiper belt and the interaction between debris disks and planets

  12. DIRECT IMAGING AND SPECTROSCOPY OF A YOUNG EXTRASOLAR KUIPER BELT IN THE NEAREST OB ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Currie, Thayne [National Astronomical Observatory of Japan, Subaru Telescope, Hilo, HI (United States); Lisse, Carey M. [Applied Physics Laboratory, The Johns Hopkins University, Laurel, MD (United States); Kuchner, Marc [NASA Goddard Space Flight Center, Greenbelt, MD (United States); Madhusudhan, Nikku [Institute for Astronomy, University of Cambridge, Cambridge (United Kingdom); Kenyon, Scott J. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (United States); Thalmann, Christian [ETH-Zurich, Zurich (Switzerland); Carson, Joseph [Department of Physics and Astronomy, The College of Charleston, Charleston, SC (United States); Debes, John [Space Telescope Science Institute, Baltimore, MD (United States)

    2015-07-01

    We describe the discovery of a bright, young Kuiper belt–like debris disk around HD 115600, a ∼1.4–1.5 M{sub ⊙}, ∼15 Myr old member of the Sco–Cen OB Association. Our H-band coronagraphy/integral field spectroscopy from the Gemini Planet Imager shows the ring has a (luminosity-scaled) semimajor axis of (∼22 AU) ∼ 48 AU, similar to the current Kuiper belt. The disk appears to have neutral-scattering dust, is eccentric (e ∼ 0.1–0.2), and could be sculpted by analogs to the outer solar system planets. Spectroscopy of the disk ansae reveal a slightly blue to gray disk color, consistent with major Kuiper belt chemical constituents, where water ice is a very plausible dominant constituent. Besides being the first object discovered with the next generation of extreme adaptive optics systems (i.e., SCExAO, GPI, SPHERE), HD 115600's debris ring and planetary system provide a key reference point for the early evolution of the solar system, the structure, and composition of the Kuiper belt and the interaction between debris disks and planets.

  13. As assessment of the flux of radionuclide contamination through the Ob and Yenisei rivers and estuaries to the Kara Sea

    International Nuclear Information System (INIS)

    Pauluszkiewicz, T.; Hibler, L.F.; Richmond, M.C.; Bradley, D.J.

    1995-01-01

    Recent data indicate that there are potentially large sources of radionuclide contamination on the Ob River system. To quantify the existing radionuclide contamination from a possible catastrophic event data and models have been used to quantify scenarios. Using a compilation of Russian data on the radionuclide contamination, hydrologic data and studies on the sediment transport process a conceptual model has been developed of the Ob system, and a numerical model has been applied to estimate the radionuclide flux to the Kara Sea. The initial results of the river modeling in the Mayak region show how important watershed flow from the marshes are to the hydrologic budget of the area. The preliminary analysis of the sediment flux indicates the need to consider the depositional (storage) regions such as the Asanow Marsh. 31 refs., 5 figs

  14. Growth of yttrium iron garnet single crystals in Na2O-B2O3 flux system in air

    International Nuclear Information System (INIS)

    Bandyopadhyay, Tarun; Saha, Prasenjit

    1977-01-01

    Detailed studies of growth of yttrium iron garnet (YIG) in the flux system Na 2 O-B 2 O 3 were made to delineate the phase stability regions of YIG and the neighbouring crystalline phases, and a tentative working diagram of Na 2 O-B 2 O 3 -YIG in air was drawn from the results of small batch crystal growth runs and solubility studies. The occurrence of a rather narrow field of YIG crystallization in this system was explained on the basis of relative solubilities of different oxides constituting YIG. Several long-time growth runs with some typical compositions were carried out in this system to evaluate its suitability for bulk growth of YIG crystals. The system, although possessing some inherent advantages, was found to suffer from limitations because the maximum size of the self-nucleated crystals grown hardly exceeded 2.00 mm. (author)

  15. Voz sobre frame relay

    OpenAIRE

    D´Elia, Gabriel Anibal

    2000-01-01

    Esta tesis trata el tema de VOFR, desde la digitalización de la voz hasta su transmisión a través de dicha red, así también como la comparación con otros medios de transporte como VOIP. Dada las características del protocolo frame relay y su disponibilidad se eligió como el medio más apropiado para la transmisión de voz y datos en forma integrada sobre una misma red. El trabajo comienza con una breve explicación de la voz, su digitalización y forma actual de transmisión a través de una red di...

  16. Réduire l'obésité chez les enfants au Mexique | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    27 avr. 2016 ... ... le Mexique connaît une « transition nutritionnelle » sous l'effet des changements qui se sont produits en ce qui concerne le régime alimentaire, la nutrition et l'activité physique. Le surpoids et l'obésité sont des facteurs de risque pour les maladies chroniques comme le diabète et le cancer, sans compter ...

  17. De la ferme à la fourchette – lutte contre l'obésité chez les enfants ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    26 avr. 2016 ... ... but de combattre l'obésité chez les enfants. La démarche repose sur trois piliers, à savoir augmenter la proportion de fruits et de légumes frais dans les repas servis à l'école, faciliter l'approvisionnement en produits auprès des agriculteurs locaux et favoriser l'augmentation de la production maraîchère.

  18. Adipokines : rôle dans l’obésité et l’insulino‐résistance

    Directory of Open Access Journals (Sweden)

    Aubert Roberte

    2003-03-01

    Full Text Available Le tissu adipeux longtemps considéré comme un organe de stockage est maintenant reconnu comme un organe endocrine. Cette revue étudie l’action de 3 adipokines sécrétées par le tissu adipeux et impliquées dans le contrôle de l’homéostasie énergétique et l’insulino‐résistance, la leptine, l’adiponectine et la résistine. La découverte de la leptine a permis la compréhension des mécanismes centraux de la prise alimentaire et de la dépense énergétique. L’espoir que la leptine puisse intervenir dans le traitement de l’obésité a été déçu, mais elle joue un rôle important dans l’insulino‐sensibilité. L’adiponectine circulante est diminuée dans l’obésité et la perte pondérale augmente son taux. Elle améliore la sensibilité à l’insuline en agissant sur le métabolisme glucidique et lipidique. Bien que pour le moment le rôle de la résistine soit encore mal défini, les études chez l’animal suggèrent qu’elle soit impliqués dans l’insulino‐résistance. Chez l’homme il n’y a pas de relation entre l’expression de la résistine et l’obésité. On peut donc se demander si la résistine, dans l’espèce humaine, est bien le lien entre obésité et diabète de type 2.

  19. Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7

    Energy Technology Data Exchange (ETDEWEB)

    Duggirala, R.; Stern, M.P.; Reinhart, L.J. [Univ. of Texas Health Science Center, San Antonio, TX (United States)] [and others

    1996-09-01

    Despite the evidence that human obesity has strong genetic determinants, efforts at identifying specific genes that influence human obesity have largely been unsuccessful. Using the sibship data obtained from 32 low-income Mexican American pedigrees ascertained on a type II diabetic proband and a multipoint variance-components method, we tested for linkage between various obesity-related traits plus associated metabolic traits and 15 markers on human chromosome 7. We found evidence for linkage between markers in the OB gene region and various traits, as follows: D7S514 and extremity skinfolds (LOD = 3.1), human carboxypeptidase A1 (HCPA1) and 32,33-split proinsulin level (LOD = 4.2), and HCPA1 and proinsulin level (LOD = 3.2). A putative susceptibility locus linked to the marker D7S514 explained 56% of the total phenotypic variation in extremity skinfolds. Variation at the HCPA1 locus explained 64% of phenotypic variation in proinsulin level and {approximately}73% of phenotypic variation in split proinsulin concentration, respectively. Weaker evidence for linkage to several other obesity-related traits (e.g., waist circumference, body-mass index, fat mass by bioimpedance, etc.) was observed for a genetic location, which is {approximately}15 cM telomeric to OB. In conclusion, our study reveals that the OB region plays a significant role in determining the phenotypic variation of both insulin precursors and obesity-related traits, at least in Mexican Americans. 66 refs., 3 figs., 4 tabs.

  20. An anomalous extinction law in the Cep OB3b young cluster: Evidence for dust processing during gas dispersal

    International Nuclear Information System (INIS)

    Allen, Thomas S.; Prchlik, Jakub J.; Megeath, S. Thomas; Gutermuth, Robert A.; Pipher, Judith L.; Naylor, Tim; Jeffries, R. D.

    2014-01-01

    We determine the extinction law through Cep OB3b, a young cluster of 3000 stars undergoing gas dispersal. The extinction is measured toward 76 background K giants identified with MMT/Hectospec spectra. Color excess ratios were determined toward each of the giants using V and R photometry from the literature, g, r, i, and z photometry from the Sloan Digital Sky Survey and J, H, and K s photometry from the Two Micron All Sky Survey. These color excess ratios were then used to construct the extinction law through the dusty material associated with Cep OB3b. The extinction law through Cep OB3b is intermediate between the R V = 3.1 and R V = 5 laws commonly used for the diffuse atomic interstellar medium and dense molecular clouds, respectively. The dependence of the extinction law on line-of-sight A V is investigated and we find the extinction law becomes shallower for regions with A V > 2.5 mag. We speculate that the intermediate dust law results from dust processing during the dispersal of the molecular cloud by the cluster.

  1. An anomalous extinction law in the Cep OB3b young cluster: Evidence for dust processing during gas dispersal

    Energy Technology Data Exchange (ETDEWEB)

    Allen, Thomas S.; Prchlik, Jakub J.; Megeath, S. Thomas [University of Toledo, Ritter Astrophysical Observatory, Department of Physics and Astronomy, Toledo, OH 43606 (United States); Gutermuth, Robert A. [Five College Astronomy Department, Smith College, Northampton, MA 01063 (United States); Pipher, Judith L. [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627 (United States); Naylor, Tim [School of Physics, University of Exeter, Exeter, UK EX4 4QL (United Kingdom); Jeffries, R. D. [Astrophysics Group, School of Physical and Geographical Sciences, Keele University, Keele, Staffordshire, UK ST5 5BG (United Kingdom)

    2014-05-10

    We determine the extinction law through Cep OB3b, a young cluster of 3000 stars undergoing gas dispersal. The extinction is measured toward 76 background K giants identified with MMT/Hectospec spectra. Color excess ratios were determined toward each of the giants using V and R photometry from the literature, g, r, i, and z photometry from the Sloan Digital Sky Survey and J, H, and K{sub s} photometry from the Two Micron All Sky Survey. These color excess ratios were then used to construct the extinction law through the dusty material associated with Cep OB3b. The extinction law through Cep OB3b is intermediate between the R{sub V} = 3.1 and R{sub V} = 5 laws commonly used for the diffuse atomic interstellar medium and dense molecular clouds, respectively. The dependence of the extinction law on line-of-sight A{sub V} is investigated and we find the extinction law becomes shallower for regions with A{sub V} > 2.5 mag. We speculate that the intermediate dust law results from dust processing during the dispersal of the molecular cloud by the cluster.

  2. Comparison of the biometric measurements calculated with Zeiss IOL-Master and WaveLight OB-820

    Directory of Open Access Journals (Sweden)

    Labiris G

    2017-04-01

    Full Text Available Georgios Labiris,1,2 Panagiota Ntonti,2 Konstantinos Ntitsos,2 Andreas Katsanos,2 Haris Sideroudi,2 Vasilios Kozobolis1,2 1Department of Ophthalmology, University Hospital of Alexandroupolis, 2Eye Institute of Thrace, Alexandroupolis, Greece Background: The primary objective of this study was to investigate the level of agreement between IOL-Master and OB-820 ocular biometers.Materials and methods: In this prospective randomized case series, we measured the anterior chamber depth (ACD, the axial length (AL, the corneal radii (R1, R2, the ratio of mean corneal radius and spherical equivalent and the corneal astigmatism (cylinder [Cyl] before and after cataract extraction surgery.Results: Significant differences between pre- and postoperative data were observed for ACD for both biometric devices (P<0.01 and Cyl parameter in IOL-Master. Range and 95% limits of agreement (LoA were clinically significantly different for AL parameter pre- and postoperatively and for R2 and radius and spherical equivalent postoperatively (P<0.001. The rest of the parameters presented sufficient 95% LoA, which imply good agreement.Conclusion: In clinical practice, the IOL-master and OB-820 should not be used interchangeably due to discrepancy in the important AL parameter. Both biometers may provide consistent results regarding Cyl, ACD and R1. Keywords: cataract, IOL-Master, OB-820, biometry, level of agreement

  3. Triggering risk factors of the burnout syndrome in OB/GYN physicians from a reference public university of Brazil.

    Science.gov (United States)

    Ferreira Bortoletti, Fátima; Teresa Benevides-Pereira, Ana Maria; Vasconcellos, Esdras Guerreiro; Siqueira, José Oliveira; Araujo Júnior, Edward; Nardozza, Luciano Marcondes Machado; Sebastiani, Ricardo Werner; Moron, Antonio Fernandes

    2012-01-01

    Objective. To identify the risk factors to the development of Burnout Syndrome in Ob/Gyn Brazilian physicians in four dimensions: emotional exhaustion (EE), professional repression (PR), dehumanization (De), and emotional distancing (EmD). Methods. A prospective cross-sectional study was realized with 48 Ob/Gyn physicians (12 lecturers, 12 attending physicians, 12 medical residents, and 12 graduate students) from Department of Obstetrics, São Paulo Federal University (UNIFESP). We used a sociodemographic questionnaire focusing on the activities (administrative, educational, healthcare, and research). We applied a Burnout Syndrome Inventory (BSI) composed of two parts: triggering factors (ISB1) and the Burnout Syndrome (ISB2). The ISB1 is composed of two scales: positive organizational conditions (POC) and negative organizational conditions (NOC). The ISB2 is composed of four scales: EE, PR, De, and EmD. Results. We observed a rate below and above average to POC and NOC, respectively. The dimensions recorded a level above average to EE, an index at the upper limit of the average to De, a median index to EmD, and a median index to PR. Conclusions. The Ob/Gyn physicians are in an area of vulnerability for the development of Burnout Syndrome due to the high level of EE and De, associated with a median index of PR. The high rate of NOC contributes to the triggering of this scenery.

  4. Representações sociais de adolescentes sobre o câncer de colo do útero

    OpenAIRE

    de Lima Fernandes, Danielle

    2011-01-01

    As representações sociais podem influenciar o comportamento. Por isso, esta dissertação se baseou na seguinte questão: quais as representações sociais das adolescentes sobre o câncer do colo do útero? O artigo de revisão teve como objetivo identificar as evidências científicas sobre as representações sociais do câncer de colo do útero nas publicações científicas. As bases de dados pesquisadas foram LILACS, ADOLEC, BDENF e MEDLINE, resultando em cinco artigos após seleção que ob...

  5. CARINA OB STARS: X-RAY SIGNATURES OF WIND SHOCKS AND MAGNETIC FIELDS

    International Nuclear Information System (INIS)

    Gagne, Marc; Fehon, Garrett; Savoy, Michael R.; Cohen, David H.; Townsley, Leisa K.; Broos, Patrick S.; Povich, Matthew S.; Corcoran, Michael F.; Walborn, Nolan R.; Remage Evans, Nancy; Moffat, Anthony F. J.; Naze, Yael; Oskinova, Lida M.

    2011-01-01

    The Chandra Carina Complex contains 200 known O- and B-type stars. The Chandra survey detected 68 of the 70 O stars and 61 of 127 known B0-B3 stars. We have assembled a publicly available optical/X-ray database to identify OB stars that depart from the canonical L X /L bol relation or whose average X-ray temperatures exceed 1 keV. Among the single O stars with high kT we identify two candidate magnetically confined wind shock sources: Tr16-22, O8.5 V, and LS 1865, O8.5 V((f)). The O4 III(fc) star HD 93250 exhibits strong, hard, variable X-rays, suggesting that it may be a massive binary with a period of >30 days. The visual O2 If* binary HD 93129A shows soft 0.6 keV and hard 1.9 keV emission components, suggesting embedded wind shocks close to the O2 If* Aa primary and colliding wind shocks between Aa and Ab. Of the 11 known O-type spectroscopic binaries, the long orbital-period systems HD 93343, HD 93403, and QZ Car have higher shock temperatures than short-period systems such as HD 93205 and FO 15. Although the X-rays from most B stars may be produced in the coronae of unseen, low-mass pre-main-sequence companions, a dozen B stars with high L X cannot be explained by a distribution of unseen companions. One of these, SS73 24 in the Treasure Chest cluster, is a new candidate Herbig Be star.

  6. Seismic velocity variation along the Izu-Bonin arc estaimated from traveltime tomography using OBS data

    Science.gov (United States)

    Obana, K.; Tamura, Y.; Takahashi, T.; Kodaira, S.

    2014-12-01

    The Izu-Bonin (Ogasawara) arc is an intra-oceanic island arc along the convergent plate boundary between the subducting Pacific and overriding Philippine Sea plates. Recent active seismic studies in the Izu-Bonin arc reveal significant along-arc variations in crustal structure [Kodaira et al., 2007]. The thickness of the arc crust shows a remarkable change between thicker Izu (~30 km) and thinner Bonin (~10 km) arcs. In addition to this, several geological and geophysical contrasts, such as seafloor topography and chemical composition of volcanic rocks, between Izu and Bonin arc have been reported [e.g., Yuasa 1992]. We have conducted earthquake observations using ocean bottom seismographs (OBSs) to reveal seismic velocity structure of the crust and mantle wedge in the Izu-Bonin arc and to investigate origin of the along-arc structure variations. We deployed 40 short-period OBSs in Izu and Bonin area in 2006 and 2009, respectively. The OBS data were processed with seismic data recorded at routine seismic stations on Hachijo-jima, Aoga-shima, and Chichi-jima operated by National Research Institute for Earth Science and Disaster Prevention (NIED). More than 5000 earthquakes were observed during about three-months observation period in each experiment. We conducted three-dimensional seismic tomography using manually picked P- and S-wave arrival time data. The obtained image shows a different seismic velocity structures in the mantle beneath the volcanic front between Izu and Bonin arcs. Low P-wave velocity anomalies in the mantle beneath the volcanic front in the Izu arc are limited at depths deeper than those in the Bonin arc. On the other hand, P-wave velocity in the low velocity anomalies beneath volcanic front in the Bonin arc is slower than that in the Izu arc. These large-scale along-arc structure variations in the mantle could relate to the geological and geophysical contrasts between Izu and Bonin arcs.

  7. NEAR-INFRARED VARIABILITY AMONG YOUNG STELLAR OBJECTS IN THE STAR FORMATION REGION CYGNUS OB7

    Energy Technology Data Exchange (ETDEWEB)

    Wolk, Scott J.; Rice, Thomas S. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Aspin, Colin [Institute for Astronomy, University of Hawaii at Manoa, 640 North Aohoku Place, Hilo, HI 96720 (United States)

    2013-08-20

    We present an analysis of near-infrared time-series photometry in J, H, and K bands for about 100 epochs of a 1 Degree-Sign Multiplication-Sign 1 Degree-Sign region of the Lynds 1003/1004 dark cloud in the Cygnus OB7 region. Augmented by data from the Wide-field Infrared Survey Explorer, we identify 96 candidate disk bearing young stellar objects (YSOs) in the region. Of these, 30 are clearly Class I or earlier. Using the Wide-Field Imaging Camera on the United Kingdom Infrared Telescope, we were able to obtain photometry over three observing seasons, with photometric uncertainty better than 0.05 mag down to J Almost-Equal-To 17. We study detailed light curves and color trajectories of {approx}50 of the YSOs in the monitored field. We investigate the variability and periodicity of the YSOs and find the data are consistent with all YSOs being variable in these wavelengths on timescales of a few years. We divide the variability into four observational classes: (1) stars with periodic variability stable over long timescales, (2) variables which exhibit short-lived cyclic behavior, (3) long-duration variables, and (4) stochastic variables. Some YSO variability defies simple classification. We can explain much of the observed variability as being due to dynamic and rotational changes in the disk, including an asymmetric or changing blocking fraction, changes to the inner disk hole size, as well as changes to the accretion rate. Overall, we find that the Class I:Class II ratio of the cluster is consistent with an age of <1 Myr, with at least one individual, wildly varying source {approx}100, 000 yr old. We have also discovered a Class II eclipsing binary system with a period of 17.87 days.

  8. FITspec: A New Algorithm for the Automated Fit of Synthetic Stellar Spectra for OB Stars

    Science.gov (United States)

    Fierro-Santillán, Celia R.; Zsargó, Janos; Klapp, Jaime; Díaz-Azuara, Santiago A.; Arrieta, Anabel; Arias, Lorena; Sigalotti, Leonardo Di G.

    2018-06-01

    In this paper we describe the FITspec code, a data mining tool for the automatic fitting of synthetic stellar spectra. The program uses a database of 27,000 CMFGEN models of stellar atmospheres arranged in a six-dimensional (6D) space, where each dimension corresponds to one model parameter. From these models a library of 2,835,000 synthetic spectra were generated covering the ultraviolet, optical, and infrared regions of the electromagnetic spectrum. Using FITspec we adjust the effective temperature and the surface gravity. From the 6D array we also get the luminosity, the metallicity, and three parameters for the stellar wind: the terminal velocity ({v}∞ ), the β exponent of the velocity law, and the clumping filling factor (F cl). Finally, the projected rotational velocity (v\\cdot \\sin i) can be obtained from the library of stellar spectra. Validation of the algorithm was performed by analyzing the spectra of a sample of eight O-type stars taken from the IACOB spectroscopic survey of Northern Galactic OB stars. The spectral lines used for the adjustment of the analyzed stars are reproduced with good accuracy. In particular, the effective temperatures calculated with the FITspec are in good agreement with those derived from spectral type and other calibrations for the same stars. The stellar luminosities and projected rotational velocities are also in good agreement with previous quantitative spectroscopic analyses in the literature. An important advantage of FITspec over traditional codes is that the time required for spectral analyses is reduced from months to a few hours.

  9. Preparedness of Ob/Gyn residents for fellowship training in gynecologic oncology

    Directory of Open Access Journals (Sweden)

    David W. Doo

    2015-04-01

    Full Text Available Residency training in obstetrics and gynecology is being challenged by increasingly stringent regulations and decreased operative experience. We sought to determine the perception of preparedness of incoming gynecologic oncology fellows for advanced surgical training in gynecologic oncology. An online survey was sent to gynecologic oncologists involved in fellowship training in the United States. They were asked to evaluate their most recent incoming clinical fellows in the domains of professionalism, level of independence/graduated responsibility, psychomotor ability, clinical evaluation and management, and academia and scholarship using a standard Likert-style scale. The response rate among attending physicians was 40% (n = 105/260 and 61% (n = 28/46 for program directors. Of those who participated, 49% reported that their incoming fellows could not independently perform a hysterectomy, 59% reported that they could not independently perform 30 min of a major procedure, 40% reported that they could not control bleeding, 40% reported that they could not recognize anatomy and tissue planes, and 58% reported that they could not dissect tissue planes. Fellows lacked an understanding of pathophysiology, treatment recommendations, and the ability to identify and treat critically ill patients. In the academic domain, respondents agreed that fellows were deficient in the areas of protocol design (54%, statistical analysis (54%, and manuscript writing (65%. These results suggest that general Ob/Gyn residency is ineffective in preparing fellows for advanced training in gynecologic oncology and should prompt a revision of the goals and objectives of resident education to correct these deficiencies.

  10. Identificarea izolatului bacterian P5 obţinut din plante de măr

    Directory of Open Access Journals (Sweden)

    MAGHER Maria

    2016-06-01

    Full Text Available The phytopathogen Erwinia amylovora (Burrill Winslow et al. is a bacterium having a major impact on pome fruit species causing identification problems at some development phenophases of trees. The aim of this paper was to identify the bacterial isolate P5 obtained from apple tree samples using classical and modern methods recommended for the bacterium E. amylovora (API 20E test, gas chromatography, PCR, DASELISA and indirect immunofluorescence. As a result of our investigations, the bacterium Erwinia amylovora was clearly identified. Taking into consideration the quarantine status of the phytopathogen E. amylovora, it is necessary to carry out the phytosanitary test sin order to monitor the presence of fire blight on pome fruit species as well as to implement timely the required preventive and curative control measures. Rezumat. Fitopatogenul Erwinia amylovora (Burrill Winslow et al. este o bacterie cu un impact deosebit asupra speciilor pomicole sămânţoase, care prezintă probleme de identificare la anumite fenofaze de dezvoltare a pomilor. Scopul acestei lucrări a fost de a identifica izolatul bacterian P5, obţinut din probe de măr, prin metode clasice şi contemporane recomandate pentru bacteria E. amylovora (testul API 20E, gaz-cromatografie, PCR, DAS-ELISA, imunofluorescenţă indirectă. În rezultatul cercetărilor a fost identificată bacteria Erwinia amylovora. Având în vedere statutul de carantină al fitopatogenului E. amylovora, se impune necesitatea efectuării obligatorii a sondajelor fitosanitare pentru monitorizarea prezenţei focului bacterian la culturile pomicole sămânţoase şi efectuarea la timp a măsurilor preventive şi curative de combatere.

  11. Sobre la muerte voluntaria

    Directory of Open Access Journals (Sweden)

    Juan Álvarez-Cienfuegos Fidalgo

    2012-03-01

    Full Text Available El problema de cómo morir en nuestra sociedad se ha convertido en una inquietud para los ciudadanos y la reflexión moral. Especialmcnte por dos razones: por el desarrollo de la tecnología médica y por el hecho de que la mayor parte de los fallecimientos tienen lugar fuera del hogar, donde tradicionalmente ocurra el deceso. El presente artículo tiene como objetivo acercarse a esta cuestión. Para ello, se parte de la autonomía del ciudadano, con derecho a decidir sobre lo que considera cuál sea su manera de vivir y de morir. A tal fin, se hace una breve introducción sobre el dolor, el suicidio y la muerte, desde un punto de vista antropológico, pasando, después, a mostrar las cuestiones relacionadas con el problema de la eutanasia, donde la atención se dirigirá, ante todo, al enjuiciamiento crítico del tenso equilibrio en el que se mantienen dos principios fundamentales de la bioética: el de no maleficencia y el de autonomía del ciudadano.The problem of how to die in modern society has become a concern for both the citizen and moral reflection for two reasons in particular: due to developments in medical technology, and because most deaths occur outside the honre, where they traditionaÍlY took place. This paper addresses this issue, starting from citizen autonomy, the right to decide on what s/he considers to be his or her way of living and dying. To this end, a brief introduction considers pain, suicide and death from an anthropological viewpoint. Questions related to the problem of euthanasia are then exposed, with particular attention to, above all the critical judgement of the tense balance in which two fundamental principies of bioethics are held, the principle of non-maleficence and that of citizen autonomy.

  12. Puente sobre el Maracaibo

    Directory of Open Access Journals (Sweden)

    Equipo Editorial

    2017-05-01

    Full Text Available Para salvar el lago de Maracaibo (Venezuela, el conocido ingeniero italiano Riccaido Morandi ha presentado un proyecto de puente para ferrocarril y carretera, de hormigón pretensado, de tramos independientes, constituyendo un sistema Gerber, que tiene una longitud total de 8.720 m y un vano central de 400 m de luz. Este último tramo, en unión de los dos adyacentes al mismo, constituirán, una vez terminada la obra, un conjunto continuo. El tablero del puente se halla a una altura de 45 m sobre el nivel del agua en la zona del canal, con objeto de permitir la navegación. El tablero, de 20,90 m de anchura total, se ha subdividido en tres partes, dos simétricas respecto al eje, laterales, de 7,20 m de anchura, para la circulación en sentidos opuestos por carretera, una plataforma central, de 5 m de ancho, para el ferrocarril y dos andenes para el paso de peatones y servicios.

  13. Sobre el nombre "Quechua"

    Directory of Open Access Journals (Sweden)

    Rodolfo Cerrón-Palomino

    1985-06-01

    Full Text Available Uno de los primeros problemas con el que a menudo tropiezael estudioso de los idiomas ágrafos, como es el caso de las lenguasaborígenes de América, es el de su denominación (glotónimo.En la medida ,en que, por razones históricas, las noticias sobretales lenguas, y por consiguiente los primeros estudios sobre lasmismas, surgen a partir del contacto con los miembros de la civilización occidental, los nombres de los distintos idiomas, así comode los grupos étnicos que los manejan, son el resultado casi siempre arbitrario cie designaciones fortuitas hechas por viajeros, misiioneros y exploradores, quienes por lo general se basan, para ello, bien en descripciones físicas de los grupo étnicos, en ciertos indios geográficos que constituyen el habitat de los mismos, e incluso en prejuicios que se nutren de un marcado europocentrismo.

  14. Increasing the number and signal-to-noise ratio of OBS traces with supervirtual refraction interferometry and free-surface multiples

    KAUST Repository

    Bharadwaj, P.; Wang, X.; Schuster, Gerard T.; McIntosh, K.

    2013-01-01

    The theory of supervirtual interferometry is modified so that free-surface related multiple refractions can be used to enhance the signal-to-noise ratio (SNR) of primary refraction events by a factor proportional to√Ns, where Ns is the number of post-critical sources for a specified refraction multiple. We also show that refraction multiples can be transformed into primary refraction events recorded at virtual hydrophones located between the actual hydrophones. Thus, data recorded by a coarse sampling of ocean bottom seismic (OBS) stations can be transformed, in principle, into a virtual survey with P times more OBS stations, where P is the order of the visible free-surface related multiple refractions. The key assumption is that the refraction arrivals are those of head waves, not pure diving waves. The effectiveness of this method is validated with both synthetic OBS data and an OBS data set recorded offshore from Taiwan. Results show the successful reconstruction of far-offset traces out to a source-receiver offset of 120 km. The primary supervirtual traces increase the number of pickable first arrivals from approximately 1600 to more than 3100 for a subset of the OBS data set where the source is only on one side of the recording stations. In addition, the head waves associated with the first-order free-surface refraction multiples allow for the creation of six new common receiver gathers recorded at virtual OBS station located about half way between the actual OBS stations. This doubles the number of OBS stations compared to the original survey and increases the total number of pickable traces from approximately 1600 to more than 6200. In summary, our results with the OBS data demonstrate that refraction interferometry can sometimes more than quadruple the number of usable traces, increase the source-receiver offsets, fill in the receiver line with a denser distribution of OBS stations, and provide more reliable picking of first arrivals. Apotential liability

  15. Increasing the number and signal-to-noise ratio of OBS traces with supervirtual refraction interferometry and free-surface multiples

    KAUST Repository

    Bharadwaj, P.

    2013-01-10

    The theory of supervirtual interferometry is modified so that free-surface related multiple refractions can be used to enhance the signal-to-noise ratio (SNR) of primary refraction events by a factor proportional to√Ns, where Ns is the number of post-critical sources for a specified refraction multiple. We also show that refraction multiples can be transformed into primary refraction events recorded at virtual hydrophones located between the actual hydrophones. Thus, data recorded by a coarse sampling of ocean bottom seismic (OBS) stations can be transformed, in principle, into a virtual survey with P times more OBS stations, where P is the order of the visible free-surface related multiple refractions. The key assumption is that the refraction arrivals are those of head waves, not pure diving waves. The effectiveness of this method is validated with both synthetic OBS data and an OBS data set recorded offshore from Taiwan. Results show the successful reconstruction of far-offset traces out to a source-receiver offset of 120 km. The primary supervirtual traces increase the number of pickable first arrivals from approximately 1600 to more than 3100 for a subset of the OBS data set where the source is only on one side of the recording stations. In addition, the head waves associated with the first-order free-surface refraction multiples allow for the creation of six new common receiver gathers recorded at virtual OBS station located about half way between the actual OBS stations. This doubles the number of OBS stations compared to the original survey and increases the total number of pickable traces from approximately 1600 to more than 6200. In summary, our results with the OBS data demonstrate that refraction interferometry can sometimes more than quadruple the number of usable traces, increase the source-receiver offsets, fill in the receiver line with a denser distribution of OBS stations, and provide more reliable picking of first arrivals. Apotential liability

  16. Algunos apuntes sobre comunidad

    Directory of Open Access Journals (Sweden)

    Clara Pérez Cárdenas

    2000-08-01

    Full Text Available Comunidad es, entre los temas de estudio del curriculum de los residentes en Medicina General Integral, uno de aquellos en las que mayores dificultades encontramos para poderlo impartir, pues la bibliografía sobre el tema está un tanto dispersa. Es un aspecto que los propios residentes no evalúan con justeza; sin embargo es de sumo interés que como profesionales de la salud no obviemos que nuestro trabajo de promoción, prevención y tratamiento, debe darse a nivel de individuo, pero también en las familias y en la comunidad como un todo, y por lo tanto debamos incorporar, al menos, nociones de lo que es una comunidad y qué es participación comunitaria para tener idea de cómo fomentarla, única vía para que nuestras acciones de salud sean más efectivasCommunity is one of the most difficult subjects to be taught among those included in the curriculum of General Comprehensive Medicine residents, since bibliography on this topic is a bit dispersed. This aspect, which is not properly evaluated by residents, is very important for health professionals to do our work of promotion, prevention and treatment not only at the level of the individual, but also at the level of the family and of the community as a whole. Therefore, we need to have some notions about community and community participation to be able to promote them, as the only way to make our health actions more effective

  17. Breakup Style and Magmatic Underplating West of the Lofoten Islands, Norway, Based on OBS Data.

    Science.gov (United States)

    Breivik, A. J.; Faleide, J. I.; Mjelde, R.; Murai, Y.; Flueh, E. R.

    2014-12-01

    The breakup of the Northeast Atlantic in the Early Eocene was magma-rich, forming the major part of the North Atlantic Igneous Province (NAIP). This is seen as extrusive and intrusive magmatism in the continental domain, and as a thicker than normal oceanic crust produced the first few million years after continental breakup. The maximum magma productivity and the duration of excess magmatism varies along the margins of Northwest Europe and East Greenland, to some extent as a function of the distance from the Iceland hotspot. The Vøring Plateau off mid-Norway is the northernmost of the margin segments in northwestern Europe with extensive magmatism. North of the plateau, magmatism dies off towards the Lofoten Margin, marking the northern boundary of the NAIP here. In 2003, as part of the Euromargins Program we collected an Ocean Bottom Seismometer (OBS) profile from mainland Norway, across the Lofoten Islands, and out into the deep ocean. Forward velocity modeling using raytracing reveals a continental margin that shows transitional features between magma-rich and magma-poor rifting. On one hand, we detect an up to 2 km thick and 40-50 km wide magmatic underplate of the outer continent, on the other hand, continental thinning is greater and intrusive magmatism less than farther south. Continental breakup also appears to be somewhat delayed compared to breakup on the Vøring Plateau, consistent with increased extension. This indicates that magmatic diking, believed to quickly lead to continental breakup of volcanic margins and thus to reduce continental thinning, played a much lesser role here than at the plateau. Early post-breakup oceanic crust is up to 8 km thick, less than half of that observed farther south. The most likely interpretation of these observations, is that the source for the excess magmatism of the NAIP was not present at the Lofoten Margin during rifting, and that the excess magmatism actually observed was the result of lateral transport from the

  18. NEAR-INFRARED VARIABILITY IN YOUNG STARS IN CYGNUS OB7

    Energy Technology Data Exchange (ETDEWEB)

    Rice, Thomas S. [Department of Astronomy, Harvard University, 60 Garden Street, Cambridge, MA 02138 (United States); Wolk, Scott J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Aspin, Colin [Institute for Astronomy, University of Hawaii at Manoa, 640 N Aohoku Pl, Hilo, HI 96720 (United States)

    2012-08-10

    We present the first results from a 124 night J, H, K near-infrared monitoring campaign of the dark cloud L 1003 in Cygnus OB7, an active star-forming region. Using three seasons of UKIRT observations spanning 1.5 years, we obtained high-quality photometry on 9200 stars down to J = 17 mag, with photometric uncertainty better than 0.04 mag. On the basis of near-infrared excesses from disks, we identify 30 pre-main-sequence stars, including 24 which are newly discovered. We analyze those stars and find that the NIR excesses are significantly variable. All 9200 stars were monitored for photometric variability; among the field star population, {approx}160 exhibited near-infrared variability (1.7% of the sample). Of the 30 young stellar objects (YSOs), 28 of them (93%) are variable at a significant level. Of the 30 YSOs, twenty-five have near-infrared excess consistent with simple disk-plus-star classical T Tauri models. Nine of these (36%) drift in color space over the course of these observations and/or since Two Micron All Sky Survey observations such that they cross the boundary defining the NIR excess criteria; effectively, they have a transient near-infrared excess. Thus, time-series JHK observations can be used to obtain a more complete sample of disk-bearing stars than single-epoch JHK observations. About half of the YSOs have color-space variations parallel to either the classical T Tauri star locus or a hybrid track which includes the dust reddening trajectory. This indicates that the NIR variability in YSOs that possess accretion disks arises from a combination of variable extinction and changes in the inner accretion disk: either in accretion rate, central hole size, and/or the inclination of the inner disk. While some variability may be due to stellar rotation, the level of variability on the individual stars can exceed a magnitude. This is a strong empirical suggestion that protoplanetary disks are quite dynamic and exhibit more complex activity on short

  19. HD 144548: A young triply eclipsing system in the Upper Scorpius OB association

    Science.gov (United States)

    Alonso, R.; Deeg, H. J.; Hoyer, S.; Lodieu, N.; Palle, E.; Sanchis-Ojeda, R.

    2015-12-01

    The star HD 144548 (=HIP 78977; TYP 6212-1273-1) has been known as a detached eclipsing binary and a bona-fide member of the Upper Scorpius OB association. Continuous photometry from the K2 mission on Campaign Two has revealed the presence of additional eclipses due to the presence of a third star in the system. These are explained by a system composed of the two previously known members of the eclipsing system (Ba and Bb) with a period of 1.63 d, orbiting around an F7-F8V star with a period of 33.945 ± 0.002 d in an eccentric orbit (eA = 0.2652 ± 0.0003). The timing of the eclipses of Ba and Bb reveals the same 33.9 d periodicity, which we interpret as the combination of a light time effect combined with dynamical perturbations on the close system. Here we combine radial velocities and analytical approximations for the timing of the eclipses to derive masses and radii for the three components of the system. We obtain a mass of 1.44 ± 0.04 M⊙ and radius of 2.41 ± 0.03 R⊙ for the A component, and almost identical masses and radii of about 0.96 M⊙ and 1.33 R⊙ for each of the two components of the close binary. HD 144548 is the first triply eclipsing system for which radial velocities of all components could be measured. Partially based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated by the Fundación Galileo Galilei of the INAF, the Nordic Optical Telescope, operated by the Nordic Optical Telescope Scientific Association, and the William Herschel Telescope (programme DDT58 - PI Lodieu) operated by the Isaac Newton Group on the island of La Palma at the Spanish Observatorio Roque de los Muchachos of the IAC. This paper includes data collected by the Kepler mission. Funding for the Kepler mission is provided by the NASA Science Mission directorate.Appendices are available in electronic form at http://www.aanda.org

  20. SPITZER SPECTROSCOPY OF CIRCUMSTELLAR DISKS IN THE 5 Myr OLD UPPER SCORPIUS OB ASSOCIATION

    International Nuclear Information System (INIS)

    Dahm, S. E.; Carpenter, John M.

    2009-01-01

    We present mid-infrared spectra between 5.2 and 38 μm for 26 disk-bearing members of the ∼5 Myr old Upper Scorpius OB association obtained with the Infrared Spectrograph (IRS) onboard the Spitzer Space Telescope. We find clear evidence for changes in the spectral characteristics of dust emission between the early-type (B+A) and late-type (K+M) infrared excess stars. The early-type members exhibit featureless continuum excesses that become apparent redward of ∼8 μm. In contrast, 10 and 20 μm silicate features or polycyclic aromatic hydrocarbon emission are present in all but one of the late-type excess members of Upper Scorpius. The strength of silicate emission among late-type Upper Scorpius members is spectral-type dependent, with the most prominent features being associated with K5-M2-type stars. By fitting the spectral energy distributions (SED) of a representative sample of low-mass stars with accretion disk models, we find that the SEDs are consistent with models having inner disk radii ranging from ∼0.2 to 1.2 AU. Complementary high-resolution (R ∼ 33, 000) optical (λλ4800-9200) spectra for the Upper Scorpius excess stars were examined for signatures of gaseous accretion. Of the 35 infrared excess stars identified in Upper Scorpius, only seven (all late-type) exhibit definitive signatures of accretion. Mass-accretion rates for these stars were estimated to range from 10 -11 to 10 -8.9 M sun yr -1 . Compared to Class II sources in Taurus-Auriga, the disk population in Upper Scorpius exhibits reduced levels of near- and mid-infrared excess emission and an order of magnitude lower mass-accretion rates. These results suggest that the disk structure has changed significantly over the 2-4 Myr in age separating these two stellar populations. The ubiquity of depleted inner disks in the Upper Scorpius excess sample implies that such disks are a common evolutionary pathway that persists for some time.

  1. OB/GYN boot cAMP using high-fidelity human simulators: enhancing residents' perceived competency, confidence in taking a leadership role, and stress hardiness.

    Science.gov (United States)

    Pliego, Jose F; Wehbe-Janek, Hania; Rajab, M Hasan; Browning, Jeff L; Fothergill, Russell E

    2008-01-01

    To evaluate the effectiveness of an obstetrical and gynecologic (Ob/Gyn) Boot Camp simulation training on perceived technical competency, confidence in a leadership role, and stress hardiness of resident training. We conducted a prospective pilot study on the effectiveness of an Ob/Gyn Boot Camp on resident training. Residents participated in an intensive immersion in clinical simulation of common obstetrical emergencies including shoulder dystocia, neonatal resuscitation, postpartum hemorrhage, and ruptured ectopic pregnancy. After the training, residents completed a Web-based survey on their perceptions of how the Ob/Gyn Boot Camp affected their 1) technical competency in the assessment and management of their patients, 2) confidence in taking a leadership role, and 3) stress hardiness. Residents rated their perceptions on a Likert scale of 1 to 5, 1 = poor to 5 = excellent. Twenty-three (14 Ob/Gyn and 9 family medicine) residents participated in this pilot study. Eighteen (78%) residents completed the online survey; 4 Ob/Gyn and 1 family medicine resident did not complete the survey. The residents reported that the simulation training stimulated an interest in learning key skills for obstetrical and gynecologic emergencies. Ob/Gyn residents reported significant improvement in their perceived technical competence and stress hardiness after the Boot Camp. However both Ob/Gyn and family medicine residents reported no significant improvement of confidence in their leadership abilities during obstetrical emergencies after the Boot Camp. Boot Camp simulation training early in the curriculum has the potential for enhancing residents' self-assessments of confidence, competency, and stress hardiness in managing obstetrical emergencies.

  2. Molecular Gas toward the Gemini OB1 Molecular Cloud Complex. II. CO Outflow Candidates with Possible WISE Associations

    Science.gov (United States)

    Li, Yingjie; Li, Fa-Cheng; Xu, Ye; Wang, Chen; Du, Xin-Yu; Yang, Wenjin; Yang, Ji

    2018-03-01

    We present a large-scale survey of CO outflows in the Gem OB1 molecular cloud complex and its surroundings, using the Purple Mountain Observatory Delingha 13.7 m telescope. A total of 198 outflow candidates were identified over a large area (∼58.5 square degrees), of which 193 are newly detected. Approximately 68% (134/198) are associated with the Gem OB1 molecular cloud complex, including clouds GGMC 1, GGMC 2, BFS 52, GGMC 3, and GGMC 4. Other regions studied are: the Local arm (Local Lynds, West Front), Swallow, Horn, and Remote cloud. Outflow candidates in GGMC 1, BFS 52, and Swallow are mainly located at ring-like or filamentary structures. To avoid excessive uncertainty in distant regions (≳3.8 kpc), we only estimated the physical parameters for clouds in the Gem OB1 molecular cloud complex and in the Local arm. In those clouds, the total kinetic energy and the energy injection rate of the identified outflow candidates are ≲1% and ≲3% of the turbulent energy and the turbulent dissipation rate of each cloud, indicating that the identified outflow candidates cannot provide enough energy to balance turbulence of their host cloud at the scale of the entire cloud (several to dozens of parsecs). The gravitational binding energy of each cloud is ≳135 times the total kinetic energy of the identified outflow candidates within the corresponding cloud, indicating that the identified outflow candidates cannot cause major disruptions to the integrity of their host cloud at the scale of the entire cloud.

  3. THE MASSIVE STAR-FORMING REGION CYGNUS OB2. II. INTEGRATED STELLAR PROPERTIES AND THE STAR FORMATION HISTORY

    International Nuclear Information System (INIS)

    Wright, N. J.; Drake, J. J.; Drew, J. E.; Vink, J. S.

    2010-01-01

    Cygnus OB2 is the nearest example of a massive star-forming region (SFR), containing over 50 O-type stars and hundreds of B-type stars. We have analyzed the properties of young stars in two fields in Cyg OB2 using the recently published deep catalog of Chandra X-ray point sources with complementary optical and near-IR photometry. Our sample is complete to ∼1 M sun (excluding A- and B-type stars that do not emit X-rays), making this the deepest study of the stellar properties and star formation history in Cyg OB2 to date. From Siess et al. isochrone fits to the near-IR color-magnitude diagram, we derive ages of 3.5 +0.75 -1.0 and 5.25 +1.5 -1.0 Myr for sources in the two fields, both with considerable spreads around the pre-main-sequence isochrones. The presence of a stellar population somewhat older than the present-day O-type stars, also fits in with the low fraction of sources with inner circumstellar disks (as traced by the K-band excess) that we find to be very low, but appropriate for a population of age ∼5 Myr. We also find that the region lacks a population of highly embedded sources that is often observed in young SFRs, suggesting star formation in the vicinity has declined. We measure the stellar mass functions (MFs) in this limit and find a power-law slope of Γ = -1.09 ± 0.13, in good agreement with the global mean value estimated by Kroupa. A steepening of the slope at higher masses is observed and suggested as due to the presence of the previous generation of stars that have lost their most massive members. Finally, combining our MF and an estimate of the radial density profile of the association suggests a total mass of Cyg OB2 of ∼3 x 10 4 M sun , similar to that of many of our Galaxy's most massive SFRs.

  4. Search for OB stars running away from young star clusters. II. The NGC 6357 star-forming region

    Science.gov (United States)

    Gvaramadze, V. V.; Kniazev, A. Y.; Kroupa, P.; Oh, S.

    2011-11-01

    Dynamical few-body encounters in the dense cores of young massive star clusters are responsible for the loss of a significant fraction of their massive stellar content. Some of the escaping (runaway) stars move through the ambient medium supersonically and can be revealed via detection of their bow shocks (visible in the infrared, optical or radio). In this paper, which is the second of a series of papers devoted to the search for OB stars running away from young ( ≲ several Myr) Galactic clusters and OB associations, we present the results of the search for bow shocks around the star-forming region NGC 6357. Using the archival data of the Midcourse Space Experiment (MSX) satellite and the Spitzer Space Telescope, and the preliminary data release of the Wide-Field Infrared Survey Explorer (WISE), we discovered seven bow shocks, whose geometry is consistent with the possibility that they are generated by stars expelled from the young (~1-2 Myr) star clusters, Pismis 24 and AH03 J1725-34.4, associated with NGC 6357. Two of the seven bow shocks are driven by the already known OB stars, HD 319881 and [N78] 34. Follow-up spectroscopy of three other bow-shock-producing stars showed that they are massive (O-type) stars as well, while the 2MASS photometry of the remaining two stars suggests that they could be B0 V stars, provided that both are located at the same distance as NGC 6357. Detection of numerous massive stars ejected from the very young clusters is consistent with the theoretical expectation that star clusters can effectively lose massive stars at the very beginning of their dynamical evolution (long before the second mechanism for production of runaway stars, based on a supernova explosion in a massive tight binary system, begins to operate) and lends strong support to the idea that probably all field OB stars have been dynamically ejected from their birth clusters. A by-product of our search for bow shocks around NGC 6357 is the detection of three circular

  5. Spodbujanje ustvarjalnosti v poletnih počitniških varstvih, sofinanciranih s strani Mestne občine Ljubljana

    OpenAIRE

    Grm, Urša

    2017-01-01

    Spodbujanje ustvarjalnosti skozi umetnost ima ključni pomen pri snovanju novih in različnih idej, izražanju domišljije, kakovostnem preživljanju časa ter izboljšanju kakovosti življenja (Knoll, 2011). Aktivira otrokove intelektualne, čustvene in motivacijske procese (Kroflič in Gobec, 1995). H kakovostnemu preživljanju časa poletnih počitnic prispeva Mestna občina Ljubljana (MOL), ki sofinancira prostočasne in preventivne programe za otroke od 1.–5. razreda osnovne šole s stalnim prebivališče...

  6. More accurate definition of liquation dome in Na2O-B2O3-SiO2 system

    International Nuclear Information System (INIS)

    Alekseeva, Z.D.; Mazurin, O.V.; Aver'yanov, V.I.; Galakhov, F.Ya.

    1977-01-01

    The liquation region in the system Na 2 O-B 2 O 3 -SiO 2 was investigated. The liquation temperatures were determined by the boundary of disappearance of opalescence in specimens with pre-induced opalescence. Extrapolation of the concentration dependences of the liquation temperature along sections with a constant SiO 2 content to a point indicates that with a SiO 2 content of 20-40% the liquation boundary in the system B 2 O 3 -SiO 2 hardly lies above 450 deg C

  7. Globules and pillars in Cygnus X. I. Herschel far-infrared imaging of the Cygnus OB2 environment

    Science.gov (United States)

    Schneider, N.; Bontemps, S.; Motte, F.; Blazere, A.; André, Ph.; Anderson, L. D.; Arzoumanian, D.; Comerón, F.; Didelon, P.; Di Francesco, J.; Duarte-Cabral, A.; Guarcello, M. G.; Hennemann, M.; Hill, T.; Könyves, V.; Marston, A.; Minier, V.; Rygl, K. L. J.; Röllig, M.; Roy, A.; Spinoglio, L.; Tremblin, P.; White, G. J.; Wright, N. J.

    2016-06-01

    The radiative feedback of massive stars on molecular clouds creates pillars, globules and other features at the interface between the H II region and molecular cloud. Optical and near-infrared observations from the ground as well as with the Hubble or Spitzer satellites have revealed numerous examples of such cloud structures. We present here Herschel far-infrared observations between 70 μm and 500 μm of the immediate environment of the rich Cygnus OB2 association, performed within the Herschel imaging survey of OB Young Stellar objects (HOBYS) program. All of the observed irradiated structures were detected based on their appearance at 70 μm, and have been classified as pillars, globules, evaporating gasous globules (EGGs), proplyd-like objects, and condensations. From the 70 μm and 160 μm flux maps, we derive the local far-ultraviolet (FUV) field on the photon dominated surfaces. In parallel, we use a census of the O-stars to estimate the overall FUV-field, that is 103-104 G0 (Habing field) close to the central OB cluster (within 10 pc) and decreases down to a few tens G0, in a distance of 50 pc. From a spectral energy distribution (SED) fit to the four longest Herschel wavelengths, we determine column density and temperature maps and derive masses, volume densities and surface densities for these structures. We find that the morphological classification corresponds to distinct physical properties. Pillars and globules are massive (~500 M⊙) and large (equivalent radius r ~ 0.6 pc) structures, corresponding to what is defined as "clumps" for molecular clouds. EGGs and proplyd-likeobjects are smaller (r ~ 0.1 and 0.2 pc) and less massive (~10 and ~30 M⊙). Cloud condensations are small (~0.1 pc), have an average mass of 35 M⊙, are dense (~6 × 104 cm-3), and can thus be described as molecular cloud "cores". All pillars and globules are oriented toward the Cyg OB2 association center and have the longest estimated photoevaporation lifetimes, a few million

  8. Informe preliminar sobre paludrina

    Directory of Open Access Journals (Sweden)

    Aquiles Peñuela Rozo

    1948-05-01

    Full Text Available En el año de 1945, Curd Davey y Rose eligieron la pirimidina como substancia de experimentación debido a que esta substancia se encuentra en las nucleo-proteinas y por su presencia en algunas sulfadrogas especial mente la sulfadiazina, de conocidas propiedades anti-palúdicas. Ensayaron la pirimidina y derivados en infestaciones por plasmodium gallinaceum en gallinas; y comprobaron que estas substancias tenían realmente acción antipalúdica. Pero al trasladar sus experiencias al hombre, encontraron que la pirimidina y sus derivados eran demasiado tóxicos. Pensando, entonces, en la similitud química del grupo de la pirimida y de la guanidina, incluyeron este último grupo en los compuestos para ensayar, descubriendo que la inclusión de la guanidina aumentaba grandemente la acción de las substancias en experiencia. Se obtuvo de esta manera un producto denominado en el numero 4-888, o paludrina, cuya fórmula o nombre químico es N. P. clorofenil N5 isopropildiguanidina, droga que se encontró muy activa contra las formas sanguíneas del Plasmodium Gallinaceum y que también se hallo activa contra las formas exoeritrocíticas del parásito. Esta capacidad de obrar sobre la fase exoeritrocítica es prácticamente exclusiva de esta substancia. Hasta hace poco tiempo esta fase exoeritrocítica, había sido demostrada solamente en trabajos de experimentación en las  aves; pero en la actualidad ha quedado también demostrada en la enfermedad humana, por experiencias del Filipino Nolasco and África, quien logro demostrar el plasmodium Vivax en el tejido retículo endotelial del pulmón de enfermos de paludismo, aunque ya Brug, en el año de 1940 había hecho comunicaciones en el mismo sentido. Se comprende la grande importancia de la paludrina, en el tratamiento del paludismo; si se considera que las recidivas de la enfermedad son debidas a la existencia de esta fase xeoeritrocítica.

  9. Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice

    Directory of Open Access Journals (Sweden)

    Peter E. M. Gibbs

    2016-01-01

    Full Text Available Insulin’s stimulation of glucose uptake by binding to the IRK extracellular domain is compromised in diabetes. We have recently described an unprecedented approach to stimulating glucose uptake. KYCCSRK (P2 peptide, corresponding to the C-terminal segment of hBVR, was effective in binding to and inducing conformational change in the IRK intracellular kinase domain. Although myristoylated P2, made of L-amino acids, was effective in cell culture, its use for animal studies was unsuitable. We developed a peptidase-resistant formulation of the peptide that was efficient in both mice and cell culture systems. The peptide was constructed of D-amino acids, in reverse order, and blocked at both termini. Delivery of the encapsulated peptide to HepG2 and HSKM cells was confirmed by its prolonged effect on stimulation of glucose uptake (>6 h. The peptide improved glucose clearance in both wild-type and Ob/Ob mice; it lowered blood glucose levels and suppressed glucose-stimulated insulin secretion. IRK activity was stimulated in the liver of treated mice and in cultured cells. The peptide potentiated function of IRK’s downstream effector, Akt-GSK3-(α,β axis. Thus, P2-based approach can be used for improving glucose uptake by cells. Also, it allows for screening peptides in vitro and in animal models for treatment of diabetes.

  10. The CIDA-QUEST large-scale survey of Orion OB1: evidence for rapid disk dissipation in a dispersed stellar population.

    Science.gov (United States)

    Briceño, C; Vivas, A K; Calvet, N; Hartmann, L; Pacheco, R; Herrera, D; Romero, L; Berlind, P; Sánchez, G; Snyder, J A; Andrews, P

    2001-01-05

    We are conducting a large-scale, multiepoch, optical photometric survey [Centro de Investigaciones de Astronomia-Quasar Equatorial Survey Team (CIDA-QUEST)] covering about 120 square degrees to identify the young low-mass stars in the Orion OB1 association. We present results for an area of 34 square degrees. Using photometric variability as our main selection criterion, as well as follow-up spectroscopy, we confirmed 168 previously unidentified pre-main sequence stars that are about 0.6 to 0.9 times the mass of the sun (Mo), with ages of about 1 million to 3 million years (Ori OB1b) and about 3 million to 10 million years (Ori OB1a). The low-mass stars are spatially coincident with the high-mass (at least 3 Mo) members of the associations. Indicators of disk accretion such as Halpha emission and near-infrared emission from dusty disks fall sharply from Ori OB1b to Ori OB1a, indicating that the time scale for disk dissipation and possibly the onset of planet formation is a few million years.

  11. Sensitivity analysis of P-waves and S-waves to gas hydrate in the Shenhu area using OBS

    Science.gov (United States)

    Xing, Lei; Liu, Xueqin; Zhang, Jin; Liu, Huaishan; Zhang, Jing; Li, Zizheng; Wang, Jianhua

    2018-02-01

    Compared to towed streamers, ocean-bottom seismometers (OBS) obtain both S-wave data and richer wavefield information. In this paper, the induced polarization method is used to conduct wavefield separation on OBS data obtained from the Shenhu area in the South China Sea. A comparison of the changes in P- and S-waves, and a comprehensive analysis of geological factors within the area, enable analysis and description of the occurrence of natural gas hydrate in the study area. Results show an increase in P-wave velocity when natural gas hydrate exists in the formation, whereas the S-wave velocity remains almost constant, as S-waves can only propagate through the rock skeleton. Therefore, the bottom-simulating reflection (BSR) response of the P-wave is better than that of the S-wave in the frequency analysis profile. In a wide-angle section, the refractive wave of the hydrate layer is evident when using P-wave components but identification is difficult with S-wave components. This velocity model illustrates the sensitivity of P- and S-wave components to gas hydrate. The use of this polarization method and results of analysis provide technical and theoretical support for research on hydrate deposits and other geological features in the Shenhu area.

  12. THE NON-THERMAL, TIME-VARIABLE RADIO EMISSION FROM Cyg OB2 no. 5: A WIND-COLLISION REGION

    International Nuclear Information System (INIS)

    Ortiz-Leon, Gisela N.; Loinard, Laurent; RodrIguez, Luis F.; Dzib, Sergio A.; Mioduszewski, Amy J.

    2011-01-01

    The radio emission from the well-studied massive stellar system Cyg OB2 no. 5 is known to fluctuate with a period of 6.7 years between a low-flux state, when the emission is entirely of free-free origin, and a high-flux state, when an additional non-thermal component (of hitherto unknown nature) appears. In this paper, we demonstrate that the radio flux of that non-thermal component is steady on timescales of hours and that its morphology is arc-like. This shows that the non-thermal emission results from the collision between the strong wind driven by the known contact binary in the system and that of an unseen companion on a somewhat eccentric orbit with a 6.7 year period and a 5-10 mas semimajor axis. Together with the previously reported wind-collision region located about 0.''8 to the northeast of the contact binary, so far Cyg OB2 no. 5 appears to be the only multiple system known to harbor two radio-imaged wind-collision regions.

  13. Paraffin oil as a "methane vector" for rapid and high cell density cultivation of Methylosinus trichosporium OB3b.

    Science.gov (United States)

    Han, Bing; Su, Tao; Wu, Hao; Gou, Zhongxuan; Xing, Xin-Hui; Jiang, Hao; Chen, Yin; Li, Xin; Murrell, J Colin

    2009-06-01

    Slow growth and relatively low cell densities of methanotrophs have limited their uses in industrial applications. In this study, a novel method for rapid cultivation of Methylosinus trichosporium OB3b was studied by adding a water-immiscible organic solvent in the medium. Paraffin oil was the most effective at enhancing cell growth and final cell density. This is at least partially due to the increase of methane gas transfer between gas and medium phases since methane solubility is higher in paraffin than in water/nitrate minimal salt medium. During cultivation with paraffin oil at 5% (v/v) in the medium, M. trichosporium OB3b cells also showed higher concentrations of the intermediary metabolites, such as formic acid and pyruvic acid, and consumed more methane compared with the control. Paraffin as methane vector to improve methanotroph growth was further studied in a 5-L fermentor at three concentrations (i.e., 2.5%, 5%, and 10%). Cell density reached about 14 g dry weight per liter with 5% paraffin, around seven times higher than that of the control (without paraffin). Cells cultivated with paraffin tended to accumulate around the interface between oil droplets and the water phase and could exist in oil phase in the case of 10% (v/v) paraffin. These results indicated that paraffin could enhance methanotroph growth, which is potentially useful in cultivation of methanotrophs in large scale in industry.

  14. Ensaios sobre economia do empreendorismo

    OpenAIRE

    Gabrielito Rauter Menezes

    2015-01-01

    Esta tese é composta por três ensaios sobre Economia do Empreendedorismo. O primeiro deles trata sobre os determinantes do empreendedorismo no Brasil a partir de modelos de escolha ocupacional, usando os microdados da Pesquisa Nacional por Amostra por Domicílios (PNAD) do ano de 2012. A estratégia empírica adotada empregou os modelos de escolha discreta na estimação da escolha ocupacional. Os resultados demonstraram que existem efeitos significativos para as variáveis: anos de estudos iniciai...

  15. Conversaciones sobre el litoral cordillerano

    OpenAIRE

    Browne,Enrique; Browne,Tomás

    2009-01-01

    Dos arquitectos dialogan sobre los Andes desde su propia vivencia. El territorio de Chile se entiende como límite natural entre mar y cordillera, donde suceden apretadamente una serie de eventos particulares: fallas geológicas, cerros que penetran en las ciudades y torrentes que bajan al mar caracterizan y diferencian sus paisajes.

  16. Sobre Humanismo y Medicina

    Directory of Open Access Journals (Sweden)

    Adolfo de Francisco Zea

    2000-12-01

    Full Text Available

    En esta disertación sobre “Humanismo y Medicina”, título del libro que tuve ocasión de publicar hace un par de años, destacaré algunas de las relaciones que existen entre la medicina y las bellas artes, concretamente la música y la pintura. La Medicina tiene como objeto de su acción al Hombre. Definida como la ciencia y el arte de prevenir, curar o aliviar la enfermedad, no tiene como meta la simple prolongación de la vida biológica.

    Su tarea consiste en postergar la muerte, prevenir o reducir los padecimientos y las deformidades, curar las enfermedades, ampliar las capacidades biológicas y psicológicas de los seres humanos y ocuparse de los sufrimientos de las personas. Para Tristam Engelhardt, es la Medicina de las personas.

    Se concibe a la persona humana como el individuo de conciencia reflexiva normal que es a la vez miembro pleno de la comunidad, con los deberes y derechos que presuponen su pertenencia a ella. A esta acepción de carácter moral de la persona humana, que corresponde a lo que se llama persona “en sentido estricto”, se agrega la acepción social, que hace relación con aquellas personas a las que se otorgan prácticamente los mismos derechos, como es el caso de los niños, de los individuos que perdieron el carácter de personas por padecer de lesiones cerebrales o demencia, y de aquellos que nunca llegarán a serlo como los retrasados mentales profundos.

    Al sostener que no todos los seres humanos son personas “en sentido estricto”, la Bioética que expone Engelhardt impone, sin embargo, como obligación moral, tratar a estos últimos con pleno respeto y comprensión. Lo que es importante acerca de nosotros mismos como seres humanos, es el hecho real de que seamos personas; no simplemente nuestra pertenencia al género Horno sapiens como tal.

    Para Víctor Frankl, la persona humana es de carácter espiritual y en tal virtud, es diferente del organismo psicofísico cuya

  17. Effects of copper mineralogy and methanobactin on cell growth and sMMO activity in Methylosinus trichosporium OB3b

    Directory of Open Access Journals (Sweden)

    C. Dennison

    2011-10-01

    Full Text Available Controls on in situ methanotroph activity are not well understood. One potentially important parameter is copper (Cu because it is the metal-centre of particulate methane monooxygenase (pMMO, the most active enzyme for oxidizing methane to methanol. Further, Cu-to-cell ratios influence the relative expression of pMMO versus the alternate soluble MMO (sMMO in some species. However, most methanotroph studies only have assessed readily soluble forms of Cu (e.g. CuCl2 and there is a dearth of Cu-related activity data for Cu sources more common in the environment. Here we quantified sMMO activity (as a practical indicator of Cu availability and growth kinetics in Methylosinus trichosporium OB3b, an organism that expresses both pMMO and sMMO, when grown on Cu-minerals with differing dissolution equilibria to assess how mineral type and methanobactin (mb might influence in situ methanotroph activity. Mb is a molecule produced by M. trichosporium OB3b that has a high affinity for Cu, reduces Cu toxicity, and may influence Cu availability in terrestrial systems. CuCO3.Cu(OH2 and CuO were chosen for study based on modelling data, reflecting more and less soluble minerals, respectively, and were found to affect M. trichosporium OB3b activity differently. Cells grew without growth lag and with active pMMO on CuCO3.Cu(OH2, regardless of the amount of mineral supplied (−1. The organism also grew well on CuO; however, significant sMMO activity was retained up to 50 μmoles Cu-total l−1, although sMMO activity was suppressed by supplemental mb and-or direct cell-mineral contact. Mb addition increased growth rates (p < 0.05 with both minerals. Results show mb broadly stimulates growth, but Cu mineralogy and mb dictate whether sMMO or pMMO is active in the cells. This explains why sMMO activity has been seen in soils with high Cu and also has implications for predicting dominant MMO activity in terrestrial bioremediation applications.

  18. Primary successions of vegetation on technogenic sand patches in oil and gas producing districts of the middle Ob' river basin

    Energy Technology Data Exchange (ETDEWEB)

    Shilova, I I

    1977-11-01

    Intensive economic exploitation of the natural resources of the oil-and-gas producing districts of the central Ob' basin has led to increased exposure of sandy patches over the landscape. These sandy areas are becoming a common site. Technogenic factors involved include, for example, construction projects, oil-drilling and the like. Exposure is accelerated by wind and water erosion. Efforts are underway to reintroduce verdure in the region, and a study has been underway of the features of the ecotope and the stages of natural overgrowth of the area of reclamation. This overgrowth is proceeding well. Vegetation is of the syngenetic succession type, involving four successive stages and formation of associations of a zonal character. Seventy-four species of yeast, 2 species of fungi, 2 of lichens, 19 of Bryophyton and 106 of vascular spore- and covered-seed plants of the area have been recorded, and are tabulated. Recultivation will require due attention to existing conditions. 14 references.

  19. Oczekiwania klienta pokolenia Y w zakresie sposobu obsługi i oferty biur podróży

    OpenAIRE

    Przybylska, Anna

    2015-01-01

    W pracy scharakteryzowano profil klienta w działalności biura podróży oraz rolę, jaką w niej odgrywa. Wskazano na znaczenie odpowiednich relacji z klientem, które wpływają na jego obsługę i zadowolenie. Krótko opisano zarządzanie relacjami z klientem oraz wytyczne do prawidłowego wprowadzenia tych zasad w firmie w celu maksymalizacji zysków. Badania zostały przeprowadzone na grupie konsumentów z przedziału wiekowego charakteryzującego pokolenie Y oraz pokolenie X – w celach ...

  20. Migration of global radioactive fallout to the Arctic Ocean (on the example of the Ob's river drainage basin).

    Science.gov (United States)

    Miroshnikov, A; Semenkov, I

    2012-11-01

    This article provides an assessment of the impact of global fallout on (137)Cs contamination in the bottom sediments of Kara Sea. The erosiveness of 10th-level river basins was estimated by landscape-geochemical and geomorphological characteristics. All 10th-level basins (n=154) were separated into three groups: mountain, mountain-lowland and plain. Four different types of basins were identified depending on the geochemical conditions of the migration of radiocaesium in the plain and mountain-lowland. Classifications of types were carried out using the geographic information systems-based approach. The Ob River's macroarena covers 3.5 million km(2). Internal drainage basins cover 23 % of the macroarena and accumulate whole radiocaesium from the global fallout. The remaining territory is transitional for the (137)Cs. The field research works performed in the three plain first-level basins allow one to estimate the radiocaesium run-off. The calculations show that 7 % of (137)Cs was removed from the first-level basin in arable land. Accumulation of radiocaesium in the first-level basin under undisturbed forest is 99.8 %. The research shows that (137)Cs transfer from the humid basins is in the range of 6.9-25.5 TBq and for semi-humid basins 5.6-285.5 TBq. The areas of these basins cover 40 and 8 % of the Ob River's macroarena, respectively. Drainage lakes and reservoir drainage basins make up 22 % of the macroarena. Mountainous and semi-arid drainage basins cover 7 % of the macroarena.

  1. TOWARD COMPLETE STATISTICS OF MASSIVE BINARY STARS: PENULTIMATE RESULTS FROM THE CYGNUS OB2 RADIAL VELOCITY SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Kobulnicky, Henry A.; Lundquist, Michael J.; Burke, Jamison; Chapman, James; Keller, Erica; Lester, Kathryn; Rolen, Emily K.; Topel, Eric; Bhattacharjee, Anirban; Smullen, Rachel A.; Álvarez, Carlos A. Vargas; Runnoe, Jessie C.; Dale, Daniel A.; Brotherton, Michael M. [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82070 (United States); Kiminki, Daniel C., E-mail: chipk@uwyo.edu, E-mail: jburke2@swarthmore.edu, E-mail: jc6380@mcla.edu, E-mail: kelle22e@mtholyoke.edu, E-mail: kvl214@lehigh.edu, E-mail: emily.k.rolen@vanderbilt.edu, E-mail: topel@stolaf.edu [Department of Astronomy, University of Arizona, Tucson, AZ 85721 (United States)

    2014-08-01

    We analyze orbital solutions for 48 massive multiple-star systems in the Cygnus OB2 association, 23 of which are newly presented here, to find that the observed distribution of orbital periods is approximately uniform in log P for P < 45 days, but it is not scale-free. Inflections in the cumulative distribution near 6 days, 14 days, and 45 days suggest key physical scales of ≅0.2, ≅0.4, and ≅1 A.U. where yet-to-be-identified phenomena create distinct features. No single power law provides a statistically compelling prescription, but if features are ignored, a power law with exponent β ≅ –0.22 provides a crude approximation over P = 1.4-2000 days, as does a piece-wise linear function with a break near 45 days. The cumulative period distribution flattens at P > 45 days, even after correction for completeness, indicating either a lower binary fraction or a shift toward low-mass companions. A high degree of similarity (91% likelihood) between the Cyg OB2 period distribution and that of other surveys suggests that the binary properties at P ≲ 25 days are determined by local physics of disk/clump fragmentation and are relatively insensitive to environmental and evolutionary factors. Fully 30% of the unbiased parent sample is a binary with period P < 45 days. Completeness corrections imply a binary fraction near 55% for P < 5000 days. The observed distribution of mass ratios 0.2 < q < 1 is consistent with uniform, while the observed distribution of eccentricities 0.1 < e < 0.6 is consistent with uniform plus an excess of e ≅ 0 systems. We identify six stars, all supergiants, that exhibit aperiodic velocity variations of ∼30 km s{sup –1} attributed to atmospheric fluctuations.

  2. Release and transport of artificial radionuclides from nuclear weapons related activities in the Ob River, Siberia over the course of the nuclear age

    International Nuclear Information System (INIS)

    Sayles, F.L.; Kenna, T.C.; Livingston, H.D.

    1999-01-01

    Studies of sediment cores from lakes on the flood plain of the Ob River, Siberia have been used to develop a history of the release, transport, and deposition of artificial radionuclides related to the development and testing of nuclear weapons over the duration of the nuclear age (∼1950 to the present) in this major Arctic river system. The Ob is of particular importance in this regard as two of the former Soviet Union's major weapons production plants, Mayak and Tomsk-7, and the Semipalatinsk test site are located within the Ob drainage basin. Accidents and intentional releases of radionuclides at both plants have been substantial, raising the issue of transport throughout this extensive river system as well as delivery to the Arctic Ocean. Our studies have included determining sediment profiles of 239,240 Pu, 137 Cs, and the natural nuclide 210 Pb and its parent 226 Ra in a number of cores from the Ob delta, as well as analysis of 239 Pu, 240 Pu, and 237 Np. The latter provide sensitive measures of the presence of non-fallout materials derived from weapons production activities

  3. Leptin receptor 170 kDa (OB-R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance

    DEFF Research Database (Denmark)

    Fuentes, T; Ara, I; Guadalupe-Grau, A

    2010-01-01

    To examine whether obesity-associated leptin resistance could be due to down-regulation of leptin receptors (OB-Rs) and/or up-regulation of suppressor of cytokine signalling 3 (SOCS3) and protein tyrosine phosphatase 1B (PTP1B) in skeletal muscle, which blunt janus kinase 2-dependent leptin...

  4. Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Erkasap, N.; Ozkurt, M. [Department of Physiology, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Erkasap, S.; Yasar, F. [Department of General Surgery, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Uzuner, K. [Department of Physiology, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Ihtiyar, E. [Department of General Surgery, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Uslu, S.; Kara, M. [Department of Biochemistry, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Bolluk, O. [Department of Biostatistics, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey)

    2013-03-19

    The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases) and metastatic colon (13 cases) cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA) and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR) for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis.

  5. Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

    International Nuclear Information System (INIS)

    Erkasap, N.; Ozkurt, M.; Erkasap, S.; Yasar, F.; Uzuner, K.; Ihtiyar, E.; Uslu, S.; Kara, M.; Bolluk, O.

    2013-01-01

    The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases) and metastatic colon (13 cases) cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA) and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR) for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis

  6. Leptin receptor (Ob-R mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

    Directory of Open Access Journals (Sweden)

    N. Erkasap

    Full Text Available The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases and metastatic colon (13 cases cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis.

  7. Examination of the site amplification factor of OBS and their application to magnitude estimation and ground-motion prediction for EEW

    Science.gov (United States)

    Hayashimoto, N.; Hoshiba, M.

    2013-12-01

    1. Introduction Ocean bottom seismograph (OBS) is useful for making Earthquake Early Warning (EEW) earlier. However, careful handling of these data is required because the installation environment of OBSs may be different from that of land stations. Site amplification factor is an important factor to estimate the magnitudes, and to predict ground motions (e.g. seismic intensity) in EEW. In this presentation, we discuss the site amplification factor of OBS in the Tonankai area of Japan from these two points of view. 2. Examination of magnitude correction of OBS In the EEW of JMA, the magnitude is estimated from the maximum amplitude of the displacement in real time. To provide the fast magnitude estimation, the magnitude-estimation algorithm switches from the P to S formula (Meew(P) to Meew(S)) depending on the expected S-phase arrival (Kamigaichi,2004). To estimate the magnitude correction for OBS, we determine Meew(P) and Meew(S) at OBSs and compare them with JMA magnitude (Mjma). We find Meew(S) at OBS is generally larger than Mjma by approximately 0.6. The slight differences of spatial distribution of Meew(S) amplification are also found among other OBSs. From the numerical simulations, Nakamura et al. (MGR,submitted) pointed out that the oceanic layer and the low-velocity sediment layers causes the large amplifications in low frequency range (0.1-0.2Hz) at OBSs. We conclude that the site effect of OBS characterized by such a low velocity sediment layers causes those amplification of Magnitude. 3. The frequency-dependent site factor of OBS estimated from Fourier spectrum ratio and their application for prediction of seismic intensity of land station We compare Fourier spectra of S-wave portion on OBSs with those on adjacent land stations. Station pair whose distance is smaller than 50 km is analyzed, and we obtain that spectral ratio of land station (MIEH05 of the KiK-net/NIED) to OBS (KMA01 of the DONET/JAMSTEC) is 5-20 for frequencies 10-20Hz for both

  8. Efeitos agudos do exercício resistido sobre marcadores da resposta inflamatória e imune

    OpenAIRE

    Guilherme Borges Pereira

    2012-01-01

    O objetivo dos pesquisadores do presente estudo foi examinar os efeitos agudos do Exercício Resistido (ER) sobre a apoptose (Anexina V+) e a migração (CX3CR1) de linfócitos T CD4+ e CD8+. 12 sujeitos adultos realizaram duas sessões de ER (3 séries em 9 exercícios) com 1 minuto (Hiper-1) e 3 minutos (Hiper-3) de intervalo entre as séries e exercícios. Não foi observada alteração significativa na contagem celular de linfócitos CD4+ e CD8+ após os protocolos Hiper-1 e Hiper-3 (p > 0,05). Foi obs...

  9. On the Binary Nature of Massive Blue Hypergiants: High-resolution X-Ray Spectroscopy Suggests That Cyg OB2 12 is a Colliding Wind Binary

    Energy Technology Data Exchange (ETDEWEB)

    Oskinova, L. M.; Hamann, W.-R.; Shenar, T.; Sander, A. A. C.; Todt, H.; Hainich, R. [Institute for Physics and Astronomy, University Potsdam, D-14476 Potsdam (Germany); Huenemoerder, D. P. [Massachusetts Institute of Technology, Kavli Institute for Astrophysics and Space Research, 70 Vassar St., Cambridge, MA 02139 (United States); Ignace, R., E-mail: lida@astro.physik.uni-potsdam.de [Department of Physics and Astronomy, East Tennessee State University, Johnson City, TN 37663 (United States)

    2017-08-10

    The blue hypergiant Cyg OB2 12 (B3Ia{sup +}) is a representative member of the class of very massive stars in a poorly understood evolutionary stage. We obtained its high-resolution X-ray spectrum using the Chandra observatory. PoWR model atmospheres were calculated to provide realistic wind opacities and to establish the wind density structure. We find that collisional de-excitation is the dominant mechanism depopulating the metastable upper levels of the forbidden lines of the He-like ions Si xiv and Mg xii. Comparison between the model and observations reveals that X-ray emission is produced in a dense plasma, which could reside only at the photosphere or in a colliding wind zone between binary components. The observed X-ray spectra are well-fitted by thermal plasma models, with average temperatures in excess of 10 MK. The wind speed in Cyg OB2 12 is not high enough to power such high temperatures, but the collision of two winds in a binary system can be sufficient. We used archival data to investigate the X-ray properties of other blue hypergiants. In general, stars of this class are not detected as X-ray sources. We suggest that our new Chandra observations of Cyg OB2 12 can be best explained if Cyg OB2 12 is a colliding wind binary possessing a late O-type companion. This makes Cyg OB2 12 only the second binary system among the 16 known Galactic hypergiants. This low binary fraction indicates that the blue hypergiants are likely products of massive binary evolution during which they either accreted a significant amount of mass or already merged with their companions.

  10. Dum lucet - bibamus sodales. Ob und wie wir Archäologen die Alten verstehen

    Directory of Open Access Journals (Sweden)

    Iva Mikl Curk

    2004-12-01

    -Schälchens, welches uns nur durch eine Publikation bekannt ist (Mratschek 1987, könnte aber den Trinker - ob er schon ein Neusiedler aus Norditalien kommend oder ein Einheimischer, welcher das Schälchen zur Gästegabe bekommen hat, war - direkter ansprechen. Mit Bleiglasur glasierte Ware trägt zum Teil im Reliefdekor noch naturgetreu abgebildete Efeu- und Weinreben-Ranken, die aber bald größtenteils stilisiert werden. Manches Gefäß von dieser Sorte wurde schon in den provinziellen Werkstätten hergestellt, in der ersten Phase allerdings als Modellarbeit der italischen (oder in Italien ausgebildeten Meister. Das beweisen sehr klar die Unterschiede an der Ausarbeitung, wenn man die Gegenstände aus Poetovio z.B. mit denen aus Carnuntum vergleicht. Aus Norditalien stammt jedenfalls auch eine Zahl der Gesichtbecher, besonders derjenigen, die als Grabbeigabe in Emona ausgegraben worden sind (Brathwaite 2001; Schindler Kaudelka, Butti Ronchetti, Schneider 2000. Da aber auch in Emona ein spezifisch gearbeitetes Gefäß mit der Darstellung vom männlichen Gesicht als Graburne gedient hat, und die Scherben aus Siedlungsspuren und aus der Töpferwerkstätte in Poetovio wieder andere Eigenschaften aufweisen, würde die Autorin, was die Bestimmung solcher Gefäße betrifft, die Meinung vertreten, dass sie sowohl für den Gebrauch im Kultus als auch zum Erheitern der Tischrunde gedacht gewesen seien, wenn auch für verschiedene Umgebungen und nicht gleich in der Ausführung. Die Reihe des oben dargestellten Trinkgeschirrs stammte sozusagen ausschließlich aus dem mittelmeerländischen Kulturkreis oder aus direktem Import. Das einheimische Element schien seine Vorstellungen nicht durch naturgetreue Abbildungen an den Artefakten des täglichen Lebens kund gegeben zu haben. In den lokalen Werkstätten sind sogar direkte Nachbildungen, auch technisch so einfach, wie das bei Keramik möglich ist, kaum vorhanden. Das wird auch durch einen Topf von Poetovio (jetzt im Landesmuseum in Graz, der

  11. Sobre aprendizaje escolar y neurociencias

    OpenAIRE

    Terigi, Flavia

    2016-01-01

    En el marco de una creciente difusión de los discursos de y sobre las neurociencias en el campo educativo en Argentina, donde enunciados extraídos del discurso neurocientífico comienzan a transformarse en emblemas de política pública, este trabajo, escrito desde el punto de vista de la educación escolar, se propone situar los alcances y límites de los aportes de estas disciplinas para comprender el aprendizaje escolar. En él se postula que la aparición rutilante de las neurociencias en educac...

  12. Polinomios perfectos sobre F2

    OpenAIRE

    Cely Rojas, Valeria

    2010-01-01

    Este trabajo muestra el status de los números perfectos y el análogo de los números perfectos en los anillos de polinomios. Además, se presentan las demostraciones de algunas propiedades de los polinomios perfectos sobre F2 de forma comprensible, basadas en el trabajo realizado por los profesores Luis Gallardo y Oliver Rahavandrainy. / Abstract. This work shows the status artis of perfect numbers and their analogue in the rings of polynomials. Proofs of some properties of perfect polynomials ...

  13. Contabilidad del impuesto sobre beneficios

    OpenAIRE

    Luceño Martínez, Haizea

    2017-01-01

    Este Trabajo Fin de Grado pretende dar una explicación al tratamiento contable del Impuesto de Sociedades. Siendo un impuesto que hay que contabilizar, pero que se calcula siguiendo criterios fiscales, lleva a tener que realizar ajustes que tendrán su repercusión contable. El punto de partida no es otra que la norma de registro y valoración 13ª del PGC, que versa sobre cómo hay que proceder a contabilizar el Gasto por Impuesto de Sociedades, que se compone tanto del Gasto por Impuesto Co...

  14. OB CITY–Definition of a Family-Based Intervention for Childhood Obesity Supported by Information and Communication Technologies

    Science.gov (United States)

    Hu, Ruofei; Cancela, Jorge; Cea, Gloria; Vlachopapadopoulou, Elpis-Athina; Fotiadis, Dimitrios I.; Fico, Giuseppe

    2016-01-01

    Childhood obesity is becoming one of the 21st century’s most important public health problems. Nowadays, the main treatment of childhood obesity is behavior intervention that aims at improve children’s lifestyle to arrest the disease. Information and communication technologies (ICTs) have not been widely employed in this intervention, and most of existing ICTs systems are not having a long-term effect. The purpose of this paper is to define a system to support family-based intervention through a state-of-the-art analysis of family-based interventions and related technological solutions first, and then using the analytic hierarchy process to derive a childhood obesity family-based behavior intervention model, and finally to provide a prototype of a system called OB CITY. The system makes use of applied behavior analysis, affective computing technologies, as well as serious game and gamification techniques, to offer long term services in all care dimensions of the family-based behavioral intervention aiming to provide positive effects to the treatment of childhood obesity. PMID:27602306

  15. CSO BOLOCAM 1.1 mm CONTINUUM MAPPING OF THE BRAID NEBULA STAR FORMATION REGION IN CYGNUS OB7

    International Nuclear Information System (INIS)

    Aspin, Colin; Beck, Tracy L.; Davis, Chris J.

    2011-01-01

    We present a 1.1 mm map of the Braid Nebula star formation region in Cygnus OB7 taken using Bolocam on the Caltech Submillimeter Observatory. Within the 1 deg 2 covered by the map, we have detected 55 cold dust clumps all of which are new detections. A number of these clumps are coincident with IRAS point sources although the majority are not. Some of the previously studied optical/near-IR sources are detected at 1.1 mm. We estimate total dust/gas masses for the 55 clumps together with peak visual extinctions. We conclude that over the whole region, approximately 20% of the clumps are associated with IRAS sources suggesting that these are protostellar objects. The remaining 80% are classed as starless clumps. In addition, both FU Orionis (FUor) like objects in the field, the Braid Star and HH 381 IRS, are associated with strong millimeter emission. This implies that FUor eruptions can occur at very early stages of pre-main-sequence life. Finally, we determine that the cumulative clump mass function for the region is very similar to that found in both the Perseus and ρ Ophiuchus star-forming regions.

  16. A WIDE-FIELD NARROWBAND OPTICAL SURVEY OF THE BRAID NEBULA STAR FORMATION REGION IN CYGNUS OB7

    International Nuclear Information System (INIS)

    Magakian, Tigran Yu.; Nikogossian, Elena H.; Movsessian, Tigran; Aspin, Colin; Pyo, Tae-Soo; Khanzadyan, Tigran; Smith, Michael D.; Mitchison, Sharon; Davis, Chris J.; Beck, Tracy L.; Moriarty-Schieven, Gerald H.

    2010-01-01

    We study the population of Herbig-Haro (HH) flows and jets in an area of Cygnus OB7 designated the Braid Nebula star formation region. This complex forms part of the L 1003 dark cloud, and hosts two FU Orionis (FUor)-like objects as well as several other active young stars. To trace outflow activity and to relate both known and newly discovered flows to young star hosts we intercompare new, deep, narrowband Hα and [S II] optical images taken on the Subaru 8 m Telescope on Mauna Kea, Hawaii. Our images show that there is considerable outflow and jet activity in this region suggesting the presence of an extensive young star population. We confirm that both of the FUor-like objects drive extensive HH flows and document further members of the flows in both objects. The L 1003 star formation complex is a highly kinematically active region with young stars in several different stages of evolution. We trace collimated outflows from numerous young stars although the origin of some HH objects remains elusive.

  17. OB CITY-Definition of a Family-Based Intervention for Childhood Obesity Supported by Information and Communication Technologies.

    Science.gov (United States)

    Hu, Ruofei; Cancela, Jorge; Arredondo Waldmeyer, Maria Teresa; Cea, Gloria; Vlachopapadopoulou, Elpis-Athina; Fotiadis, Dimitrios I; Fico, Giuseppe

    2016-01-01

    Childhood obesity is becoming one of the 21st century's most important public health problems. Nowadays, the main treatment of childhood obesity is behavior intervention that aims at improve children's lifestyle to arrest the disease. Information and communication technologies (ICTs) have not been widely employed in this intervention, and most of existing ICTs systems are not having a long-term effect. The purpose of this paper is to define a system to support family-based intervention through a state-of-the-art analysis of family-based interventions and related technological solutions first, and then using the analytic hierarchy process to derive a childhood obesity family-based behavior intervention model, and finally to provide a prototype of a system called OB CITY. The system makes use of applied behavior analysis, affective computing technologies, as well as serious game and gamification techniques, to offer long term services in all care dimensions of the family-based behavioral intervention aiming to provide positive effects to the treatment of childhood obesity.

  18. VizieR Online Data Catalog: Extinction law in the Cep OB3b young cluster (Allen+, 2014)

    Science.gov (United States)

    Allen, T. S.; Prchlik, J. J.; Megeath, S. T.; Gutermuth, R. A.; Pipher, J. L.; Naylor, T.; Jeffries, R. D.

    2017-06-01

    We use Johnson V and Cousins Rc (hereafter called VR) band phot from the Isaac Newton Telescope (INT), compiled in the catalog of Littlefair et al. (2010, J/MNRAS/403/545). The R-band photometry was obtained using the Sloan r filter. It was calibrated against photometric standard stars measured in the Cousins Rc filter with an arbitrary zero point. Moderate resolution ((λ/Δλ)~1000-2000, FWHM resolution of about 6 Å) optical spectra (covering 4000-9000 Å) were obtained for ~1700 sources toward Cep OB3b using the multi-fiber spectrograph Hectospec on the MMT telescope. About 600 sources were selected for observation because they were determined to be possible cluster members (Allen et al. 2012, J/ApJ/750/125), based on indicators of youth, such as IR emission due to circumstellar dusty material and heightened X-ray activity. We use an extinction map from Allen et al. (2012, J/ApJ/750/125) to initially estimate the extinction toward each source. This map is derived using the 2MASS Point Source Catalog (Skrutskie et al. 2006AJ....131.1163S, Cat. VII/233) H and Ks band photometry of background stars. (1 data file).

  19. Analysis of seismic reflectivity and AVO pattern of BSR using OBS data in the southwestern offshore region of Taiwan

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, W.B.; Yang, H.R. [Jinwen Univ. of Science and Technology, Hsintien City, Taipei County, Taiwan (China). Dept. of Environment and Property Management; Schnurle, P.; Liu, C.S. [National Taiwan Univ., Taipei, Taiwan (China). Inst. of Oceanography; Lee, C.S. [National Taiwan Ocean Univ., Keelung, Taiwan (China). Inst. of Applied Earth Science; Wang, Y.; Chung, S.H.; Chen, S.C. [Ministry of Economic Affairs, Taiwan (China). Central Geological Survey

    2008-07-01

    Regional multi-channel seismic reflection profiles that were conducted in Taiwan from 2003 to 2006 resulted in the identification of a gas hydrate-related bottom simulating reflector (BSR) in the broad southwestern offshore region of Taiwan. In order to understand the regional distribution of methane hydrate bearing layers and explore concentrated hydrate bearing layers, this paper presented a comprehensive analysis of reflection coefficient and amplitude-versus-offset (AVO) pattern of BSR using ocean bottom seismographs (OBSs) seismic data acquired in the southwestern offshore region of Taiwan. The study focused on the analysis and interpretation of airgun array signals recorded by OBSs during 2004 and 2006. Ten profiles of seismic reflection/refraction with a total length of about 140 km and recorded by 50 recovered OBSs were acquired on the active and passive margins in offshore southwestern Taiwan. Amplitudes of the direct water arrival, the multiple, and the BSR were picked interactively for all the OBS lines. A quantitative representation of reflector strength was provided by calculation of reflection coefficients. In general, the seafloor reflection coefficients for the active and passive margins were estimated as 0.1-0.25. The paper presented the data and analysis as well as the results of the study. It was concluded that the results of calculated reflection coefficient of the BSR in offshore southwest Taiwan suggested that inferred hydrate concentration for the passive margin profiles was relatively higher than that for the active margin profiles. 4 refs.

  20. Spatial clustering of summer temperature maxima from the CNRM-CM5 climate model ensembles & E-OBS over Europe

    Directory of Open Access Journals (Sweden)

    Margot Bador

    2015-09-01

    Full Text Available Reducing the dimensionality of the complex spatio-temporal variables associated with climate modeling, especially ensembles of climate models, is a challenging and important objective. For studies of detection and attribution, it is especially important to maintain information related to the extreme values of the atmospheric processes. Typical methods for data reduction involve summarizing climate model output information through means and variances, which does not preserve any information about the extremes. In order to help solve this challenge, a dependence summary measure appropriate for extreme values must be inferred. Here, we adapt one such measure from a recent study to a larger domain with a different variable and gridded data from observations and climate model ensembles, i.e. E-OBS observations and the CNRM-CM5 model. The handling of such ensembles of data is proposed, as well as a comparison of the spatial clusterings between two different ensembles, here a present-day and a future ensemble of climate simulations. This method yields valid information concerning extremes, while greatly reducing the data set.

  1. Gas expulsions and biological activity recorded offshore Molene Island, Brittany (France): video supervised recording of OBS data and analogue modelling

    Science.gov (United States)

    Klingelhoefer, F.; Géli, L.; Dellong, D.; Evangelia, B.; Tary, J. B.; Bayrakci, G.; Lantéri, N.; Lin, J. Y.; Chen, Y. F.; Chang, E. T. Y.

    2016-12-01

    Ocean bottom seismometers (OBS) commonly record signals from Short Duration Events (SDEs), having characteristics that are very different from those produced by tectonic earthquakes, e.g.: durations Brittany within the field of view of the EMSO-Molene underwater observatory, at a water depth of 12 m. The camera images and the recordings reveal the presence of crabs, octopus and several species of fish. Other acoustic signals can be related to the presence of moving algae or the influence from bad weather. Tides produce characteristic curves in the noise recorded on the geophones. SDEs have been recorded on both instruments, that may well have been caused by gas expulsions from the seabed into the water. In order to verify this hypothesis, an aquarium was filled with water overlying an even grain-sized quartz sand layer. A constant air supply through a narrow tube produced gas bubbles in a regular manner and an immersed ocean bottom geophone recorded the resulting acoustic signals. The bubbles tend to have a uniform size and to produce a waveform very close to those found on the OBSs. By comparing the number of SDEs and the volume of escaped air, estimates can be made regarding the volume of gas escaping the seafloor in different environments.

  2. Génétique épidémiologique et moléculaire de l’obésité humaine

    Directory of Open Access Journals (Sweden)

    Iron Albert

    2000-01-01

    Full Text Available L’obésité est une pathologie majeure pour plusieurs raisons qu’il est difficile de hiérarchiser. D’abord parce qu’elle est commune, concernant aujourd’hui près d’un individu sur trois dans les pays industrialisés. Ensuite, parce qu’elle est grave en raison des complications nombreuses et sévères, parmi lesquelles on peut citer des cardiopathies, le diabète, l’HTA, des cancers, etc. Enfin, parce que répondant à la définition de maladie multifactorielle résultant de l’interaction entre des facteurs héréditaires et des facteurs environnementaux, sa connaissance a beaucoup progressé ces dernières années, notamment grâce à l’apport de la génétique moléculaire. À l’échelon individuel et d’une manière simple, on peut définir l’obésité comme résultant d’un excès de tissu adipeux qui va se traduire par un poids élevé par rapport à ce qu’on peut considérer comme étant un poids idéal donné par la formule de Lorentz : Poids idéal (kg = Taille (cm – 100 – [Taille (cm – 150]/4 (homme ou 2,5 (femme Sous l’angle épidémiologique, c’est-à-dire à l’échelle des populations, l’obésité sera définie à partir de critères de nature anthropologique utilisés aussi en clinique pour typer le patient obèse. On peut prendre en compte le rapport du tour de hanche sur le tour de taille (qui permet de définir une obésité de type androïde ou gynoïde selon que ce rapport est supérieur ou inférieur à 0,85 ou la mesure de l’adiposité évaluée par l’appréciation des plis cutanés (en particulier le pli tricipital ou surtout l’indice de corpulence qui est le critère majeur des épidémiologistes pour l’étude de l’obésité chez l’adulte. Cet indice est la référence pour la définition de l’obésité chez l’adulte ; il est aussi appelé indice de masse corporelle (IMC ou indice de Quetelet ; il exprime le rapport du poids (en kg au carré de la taille (en m

  3. Trening za razvijanje občutka za števila in količine pri predšolskih otrocih s posebnimi potrebami

    OpenAIRE

    Kuplenk, Petra

    2017-01-01

    Tako otroci kot tudi odrasli se z matematiko srečujemo na vsakem koraku, pa naj bo to na poti v vrtec, službo ali pa pri delu doma. Matematika vsakodnevno vpliva na naše življenje in delo. Na delovnem mestu, v vrtcu, opažam vse večje težave otrok s posebnimi potrebami na področju razvoja občutka za števila in količine. V predšolskem obdobju je namreč nujno, da otroci razvijejo občutek za števila in količine, saj vsa nadaljnja matematična znanja temeljijo na usvojenih spretnostih. V empirič...

  4. Extinctions and Distances to Dark Clouds from 2MASS, MegaCam and IPHAS Surveys: LDN 1525 in the Direction of the Aur OB1 Association

    Directory of Open Access Journals (Sweden)

    Straižys V.

    2010-12-01

    Full Text Available The possibility of applying photometry from the 2MASS J, H, Ks, MegaCam u, g and IPHAS r, i, Hα surveys for determining the distance to the dark cloud LDN1525 (TGU 1192 in the direction of the Aur OB1 association is investigated using the red clump giants. The main dust cloud, probably related to the emission nebulae Sh 2-232, Sh 2-233, Sh 2-235, the molecular cloud and the association Aur OB2, is found to be located at a distance of 1.3 kpc from the Sun. The nebula Sh 2-231 can be an object of the Perseus arm. The maximum extinction AV found in the cloud is close to 6 mag.

  5. Carbenoxolone treatment ameliorated metabolic syndrome in WNIN/Ob obese rats, but induced severe fat loss and glucose intolerance in lean rats.

    Directory of Open Access Journals (Sweden)

    Siva Sankara Vara Prasad Sakamuri

    Full Text Available BACKGROUND: 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1 regulates local glucocorticoid action in tissues by catalysing conversion of inactive glucocorticoids to active glucocorticoids. 11β-HSD1 inhibition ameliorates obesity and associated co-morbidities. Here, we tested the effect of 11β-HSD inhibitor, carbenoxolone (CBX on obesity and associated comorbidities in obese rats of WNIN/Ob strain, a new animal model for genetic obesity. METHODOLOGY/PRINCIPAL FINDINGS: Subcutaneous injection of CBX (50 mg/kg body weight or volume-matched vehicle was given once daily for four weeks to three month-old WNIN/Ob lean and obese rats (n = 6 for each phenotype and for each treatment. Body composition, plasma lipids and hormones were assayed. Hepatic steatosis, adipose tissue morphology, inflammation and fibrosis were also studied. Insulin resistance and glucose intolerance were determined along with tissue glycogen content. Gene expressions were determined in liver and adipose tissue. CBX significantly inhibited 11β-HSD1 activity in liver and adipose tissue of WNIN/Ob lean and obese rats. CBX significantly decreased body fat percentage, hypertriglyceridemia, hypercholesterolemia, insulin resistance in obese rats. CBX ameliorated hepatic steatosis, adipocyte hypertrophy, adipose tissue inflammation and fibrosis in obese rats. Tissue glycogen content was significantly decreased by CBX in liver and adipose tissue of obese rats. Severe fat loss and glucose- intolerance were observed in lean rats after CBX treatment. CONCLUSIONS/SIGNIFICANCE: We conclude that 11β-HSD1 inhibition by CBX decreases obesity and associated co-morbidities in WNIN/Ob obese rats. Our study supports the hypothesis that inhibition of 11β-HSD1 is a key strategy to treat metabolic syndrome. Severe fat loss and glucose -intolerance by CBX treatment in lean rats suggest that chronic 11β-HSD1 inhibition may lead to insulin resistance in normal conditions.

  6. New Low-mass Stars in the 25 Orionis Stellar Group and Orion OB1a Sub-association from SDSS-III/BOSS Spectroscopy

    Science.gov (United States)

    Suárez, Genaro; Downes, Juan José; Román-Zúñiga, Carlos; Covey, Kevin R.; Tapia, Mauricio; Hernández, Jesús; Petr-Gotzens, Monika G.; Stassun, Keivan G.; Briceño, César

    2017-07-01

    The Orion OB1a sub-association is a rich low-mass star (LMS) region. Previous spectroscopic studies have confirmed 160 LMSs in the 25 Orionis stellar group (25 Ori), which is the most prominent overdensity of Orion OB1a. Nonetheless, the current census of the 25 Ori members is estimated to be lower than 50% complete, leaving a large number of members to be still confirmed. We retrieved 172 low-resolution stellar spectra in Orion OB1a observed as ancillary science in the SDSS-III/BOSS survey, for which we classified their spectral types and determined physical parameters. To determine memberships, we analyzed the {{{H}}}α emission, Li I λ6708 absorption, and Na I λλ8183, 8195 absorption as youth indicators in stars classified as M type. We report 50 new LMSs spread across the 25 Orionis, ASCC 18, and ASCC 20 stellar groups with spectral types from M0 to M6, corresponding to a mass range of 0.10≤slant m/{M}⊙ ≤slant 0.58. This represents an increase of 50% in the number of known LMSs in the area and a net increase of 20% in the number of 25 Ori members in this mass range. Using parallax values from the Gaia DR1 catalog, we estimated the distances to these three stellar groups and found that they are all co-distant, at 338 ± 66 pc. We analyzed the spectral energy distributions of these LMSs and classified their disks into evolutionary classes. Using H-R diagrams, we found a suggestion that 25 Ori could be slightly older than the other two observed groups in Orion OB1a.

  7. Enhancing the Quality of Service for Real Time Traffic over Optical Burst Switching (OBS Networks with Ensuring the Fairness for Other Traffics.

    Directory of Open Access Journals (Sweden)

    Mohammed A Al-Shargabi

    Full Text Available Optical burst switching (OBS networks have been attracting much consideration as a promising approach to build the next generation optical Internet. A solution for enhancing the Quality of Service (QoS for high priority real time traffic over OBS with the fairness among the traffic types is absent in current OBS' QoS schemes. In this paper we present a novel Real Time Quality of Service with Fairness Ratio (RT-QoSFR scheme that can adapt the burst assembly parameters according to the traffic QoS needs in order to enhance the real time traffic QoS requirements and to ensure the fairness for other traffic. The results show that RT-QoSFR scheme is able to fulfill the real time traffic requirements (end to end delay, and loss rate ensuring the fairness for other traffics under various conditions such as the type of real time traffic and traffic load. RT-QoSFR can guarantee that the delay of the real time traffic packets does not exceed the maximum packets transfer delay value. Furthermore, it can reduce the real time traffic packets loss, at the same time guarantee the fairness for non real time traffic packets by determining the ratio of real time traffic inside the burst to be 50-60%, 30-40%, and 10-20% for high, normal, and low traffic loads respectively.

  8. Recursos y enlaces sobre comunidades de aprendizaje

    OpenAIRE

    Ferrer Esteban, Gerard

    2005-01-01

    Obras y artículos sobre el proyecto Comunidades de Aprendizaje desarrollado en el Estado español. Tesis doctorales sobre comunidades de aprendizaje. Fundamentación teórica de las comunidades de aprendizaje. Sitios en Internet relacionados con las comunidades de aprendizaje y proyectos afines de desarrollo comunitario en contextos escolares.

  9. Efecto cristal. Reflexiones sobre arquitectura

    Directory of Open Access Journals (Sweden)

    Dr. Arq. Carlos Pantaleón Panaro

    2017-12-01

    Full Text Available ESPEJISMO es una ilusión óptica debido a la reflexión total de la luz cuando atraviesa capas de aire de densidad distinta, con lo cual los objetos lejanos dan una imagen invertida, como si se reflejaran sobre el agua, tal como ocurre en las llanuras de los desiertos. 1 La definición de espejismo nos explica que es una ilusión, una ficción, un desvarío, un delirio. Algo que no es real ni verdadero, la apariencia engañosa de algo que no existe. ¿Pero no existe, realmente? Tal vez se pueda decir, desde algún punto de vista, que una imagen ilusoria no es real. Pero ¿podríamos afirmarlo desde el punto de vista del fenómeno de la percepción? Si lo vemos, ¿no tendríamos derecho a decir que es real? ¿Algo tiene que ser material y poder tocarse, para ser real? ¿No basta simplemente con verlo? Este artículo de reflexión trata sobre el tema de lo ilusorio, de los espejismos y apariencias engañosas que, no obstante su naturaleza falaz, existen y se perciben, y son procesados por nuestra mente como fenómenos sensoriales que conforman nuestra percepción. El hilo conductor es un viaje a través de diferentes paisajes espejados: el del azar, el de las artes y el de la arquitectura. 1Diccionario de la Real Academia Española

  10. [Modeling of Processes of Migration and Accumulation of Radionuclides in Freshwater Ecosystems by the Example of the Samson, Lev, Vandras Rivers Related to the Ob-Irtysh River Basin].

    Science.gov (United States)

    Trapeznikov, A V; Korzhavin, A V; Trapeznikova, V N; Nikolkin, V N

    2016-01-01

    Mathematical models of horizontal distribution and migration of radionuclides are presented in water and floodplain soils of the Samson-Lev-Vandras river system related to the Ob-Irtysh river basin. Integral inventory of radionuclides in the main components of the river ecosystems is calculated. The estimated annual discharge of radionuclides from the Vandras river to the Great Salym river is given. The effect of the removal of man-made radionuclides in the Samson, Lev, Vandras rivers on radioactive contamination of the Ob-Irtysh river system is shown in comparison with the Techa river, that also belongs to the Ob-Irtysh river basin. Despite the presence of an additional radioactive contamination of the Samson floodplain, the transfer of radioactive substances in the Samson, Lev, Vandras rivers has a much smaller impact on the contamination of the Ob-Irtysh river system, compared to the Techa river, prone to a large-scale radioactive contamination.

  11. Borate mineral assemblages in the system Na2OCaOMgOB2O3H2O

    Science.gov (United States)

    Christ, C.L.; Truesdell, A.H.; Erd, Richard C.

    1967-01-01

    he significant known hydrated borate mineral assemblages (principally of the western United States) in the system Na2OCaOz.sbnd;MgOB2O3H2O are expressible in three ternary composition diagrams. Phase rule interpretation of the diagrams is consistent with observation, if the activity of H2O is generally considered to be determined by the geologic environment. The absence of conflicting tie-lines on a diagram indicates that the several mineral assemblages of the diagram were formed under relatively narrow ranges of temperature and pressure. The known structural as well as empirical formulas for the minerals are listed, and the more recent (since 1960) crystal structure findings are discussed briefly. Schematic Gibbs free energy-composition diagrams based on known solubility-temperature relations in the systems Na2B4O7-H2O and Na2B4O7-NaCl-H2O, are highly useful in the interpretation and prediction of the stability relations in these systems; in particular these diagrams indicate clearly that tincalconite, although geologically important, is everywhere a metastable phase. Crystal-chemical considerations indicate that the same thermodynamic and kinetic behavior observed in the Na2B4O7-H2O system will hold in the Ca2B6O11-H2O system. This conclusion is confirmed by the petrologic evidence. The chemical relations among the mineral assemblages of a ternary diagram are expressed by a schematic "activity-activity" diagram. These activity-activity diagrams permit the tracing-out of the paragenetic sequences as a function of changing cation and H2O activities. ?? 1967.

  12. X-RAY EMISSION FROM THE DOUBLE-BINARY OB-STAR SYSTEM QZ CAR (HD 93206)

    International Nuclear Information System (INIS)

    Parkin, E. R.; Naze, Y.; Rauw, G.; Broos, P. S.; Townsley, L. K.; Pittard, J. M.; Moffat, A. F. J.; Oskinova, L. M.; Waldron, W. L.

    2011-01-01

    X-ray observations of the double-binary OB-star system QZ Car (HD 93206) obtained with the Chandra X-ray Observatory over a period of roughly 2 years are presented. The respective orbits of systems A (O9.7 I+b2 v, P A = 21 days) and B (O8 III+o9 v, P B = 6 days) are reasonably well sampled by the observations, allowing the origin of the X-ray emission to be examined in detail. The X-ray spectra can be well fitted by an attenuated three-temperature thermal plasma model, characterized by cool, moderate, and hot plasma components at kT ≅ 0.2, 0.7, and 2 keV, respectively, and a circumstellar absorption of ≅0.2 x 10 22 cm -2 . Although the hot plasma component could be indicating the presence of wind-wind collision shocks in the system, the model fluxes calculated from spectral fits, with an average value of ≅7 x 10 -13 erg s -1 cm -2 , do not show a clear correlation with the orbits of the two constituent binaries. A semi-analytical model of QZ Car reveals that a stable momentum balance may not be established in either system A or B. Yet, despite this, system B is expected to produce an observed X-ray flux well in excess of the observations. If one considers the wind of the O8 III star to be disrupted by mass transfer, the model and observations are in far better agreement, which lends support to the previous suggestion of mass transfer in the O8 III + o9 v binary. We conclude that the X-ray emission from QZ Car can be reasonably well accounted for by a combination of contributions mainly from the single stars and the mutual wind-wind collision between systems A and B.

  13. Development and implementation of an automated system to exchange attenuators of the OB85/1 gamma irradiator

    International Nuclear Information System (INIS)

    Silva Junior, Iremar A.; Ramos, Marcio A.G.; Carvalho, Valdir S.; Diniz, Raphael E.; Cescon, Claudinei T.; Vivolo, Vitor; Potiens, Maria da Penha A.

    2011-01-01

    In order to improve the calibration process of portable detectors of the Instrument Calibration Laboratory of IPEN, an automated system to exchange the attenuators of the OB85/1 irradiator system was developed. This automation was developed following this sequence: (i) development of the device with the cooperation of the IPEN Sector of Projects, using the Solid Edge software to design the mechanical part of the exchanging device of the attenuators, in 3D; (ii) simulation with the Festo's FluidSim software to define the pneumatic components and their respective actuators; (iii) machining and assembly of mechanical parts; (iv) assembly of pneumatic components and their actuators, like magnetic pneumatic cylinders, which allow the use of magnetic sensors, used to confirm the attenuators opened or closed positions: actuators 5/2 each, with double solenoid; (v) assembly of the control panel for operating the device remotely from the operating room. With this automation, the technicians in charge of the detectors calibration and research testing will have no hand contact with lead attenuators, improving the calibration process due to the decrease in time spent with manual shift from the attenuators and avoiding accidents, like the fall of the lead attenuators. It has been a concern of the LCI-IPEN group the decrease in the time spent by the technicians in the calibration room controlled areas should follow the recommendations of the radiological protection rules, which recommend the shortest time possible of workers in these areas. Automated systems have, usually, a better rate of reproducibility, due to the small participation by the system operator, so the LCI-IPEN is following the trend of several laboratories and automating its processes. (author)

  14. Association entre le travail par quarts et l’obésité chez les hommes dans le nord-est de l’Ontario

    Directory of Open Access Journals (Sweden)

    Anne Grundy

    2017-01-01

    Full Text Available Introduction : Même si certaines études suggèrent une association entre le travail par quarts et l’obésité, peu sont fondées sur la population ou tiennent compte de divers horaires de travail par quarts. L’obésité étant associée à plusieurs problèmes de santé chroniques, il est important de comprendre quelles formes de travail par quarts ont une incidence sur elle et d’effectuer des travaux permettant d’évaluer de façon plus détaillée l’exposition au travail par quarts. Méthodologie : Au moyen d’une régression logistique polytomique multivariée, nous avons étudié l’association entre le travail par quarts (de soir ou nuit, par quarts ou autre type de rotation et le surpoids et l’obésité, en fonction d’une mesure transversale de l’indice de masse corporelle chez 1 561 hommes. Ces hommes avaient déjà servi de témoins dans une étude cas-témoins sur le cancer de la prostate menée dans le nord-est de l’Ontario de 1995 à 1999. Nous avons obtenu l’information sur leurs antécédents de travail (notamment sur le travail par quarts, leur taille et leur poids à partir de données autodéclarées recueillies par questionnaire. Résultats : Nous avons observé une association entre le fait d’avoir déjà travaillé par quarts (par opposition au fait de n’avoir jamais travaillé par quarts et le surpoids (RC [rapport de cotes] = 1,34; IC [intervalle de confiance] à 95 % : 1,05 à 1,73 ainsi que l’obésité (RC = 1,57; IC à 95 % : 1,12 à 2,21. Nous avons également observé des associations statistiquement non significatives avec le fait d’avoir déjà travaillé (par opposition au fait de n’avoir jamais travaillé de façon permanente selon un quart de soir ou de nuit. Nous avons par ailleurs observé une tendance à la hausse statistiquement significative en ce qui concerne le risque de surpoids et d’obésité en fonction de la durée du travail par quarts. Conclusion : Tant l

  15. Puente sobre el rio Medway

    Directory of Open Access Journals (Sweden)

    Freeman, Fox, Ingenieros

    1963-02-01

    have been prestressed both longitudinally and transversally. Between the two circulation roadways an elastic barrier has been placed, supported on metal posts.El puente sobre el río Medway tiene la misión de salvar dicho río en el nuevo trazado de carretera necesario para aliviar el denso tráfico estival entre Dower y Londres. Está situado en las proximidades de la ciudad de Rochester. La estructura se ha construido utilizando las vías de concurso. De todos los tipos presentados se eligió una estructura de hormigón armado. La longitud total de la obra es de 1.000 m. Los tres tramos principales de la obra salvan el río. El central es de 152 m de luz, y los dos adyacentes son de 103 m cada uno. Los accesos tienen un total de 18 tramos, que arrojan una longitud de 654 m. La anchura del puente es de 34 m, y la calzada se ha subdividido en dos direcciones de tráfico de 7,30 m cada una y, además, se han dejado dos espaldones laterales de 2,40 m de anchura. En planta se puede admitir que el puente tiene una alineación recta con una ligerísima curva, y que en el plano vertical presenta una pendiente de desagüe entre las pilas 9 y 10. Los estribos son de hormigón armado: tipo celular el del este y de hormigón en masa el del oeste. Los estribos se apoyan sobre pilotes hexagonales de hormigón armado cuya circunferencia circunscrita tiene 55 cm de radio y de 12 a 20 m de longitud. Cuando el firme se hallaba a profundidades inferiores a 6 m, los estribos se cimentaban directamente sobre el firme. Las pilas constituyen pórtico y tienen una altura variable de 9 a 30 m sobre el nivel del suelo. Los tramos de acceso forman una estructura continua simplemente apoyada. Cada tramo se compone de ocho vigas longitudinales de 30 a 41 m de longitud y de 190 toneladas cada una. Estas vigas son del tipo pretensado y prefabricado. El tramo central es del tipo cantilever, constituido por dos brazos, de 30 m de longitud, formados por vigas cajón. Cada una de estas vigas consta

  16. Puente sobre el Oosterschelde, Holanda

    Directory of Open Access Journals (Sweden)

    Hoving, H. T.

    1967-03-01

    Full Text Available This new bridge, forming part of the Delta project, is made of concrete, and was built by successive overhangs. Precast units were mainly used. The bridge is 5,000 m long, and is 11.85 m wide. The main spans are 95 m in length, except one, which can be opened up to sea traffic, which is 40 m long. The free height of the bridge over the sea is 15 m, which is insufficient for large ships. This required that one of the spans, in deep water, should open up, on hinges, and provide free passage to large ships. The intermediate bridge supports are of special interest. They rest on piles which go down to 38 m. They are hollow, cylindrical, of 4.35 m external diameter, and are driven into the ground in several stages, as they penetrate through the sands at the bottom of the Oosterschelde. To drive them in, an excavating device, inside the pile, was utilised, and also a dredging and suction mechanism, to clean out the bottom, and allow the piles to sink by gravity. But when external friction did not allow this to happen, the piles were weighed down with up to 500 tons of ballast. A series of three of these piles, in a row, makes up each bridge support. A cross member over the pile heads supports, in turn, the bridge deck. The bridge was built in successive sections, overhanging from each support, and then finally connected with a central portion. Use of precast units has been very extensive, so that the bridge can be justiaflably regarded as being prefabricated.Este nuevo puente, que forma parte del Plan de obras denominadas del Delta, es de hormigón y se ha construido por el procedimiento de voladizos sucesivos, utilizando, en su mayor parte, elementos prefabricados. Tiene una longitud total de 5.000 m; una anchura de 11,85 m; tramos principales de 95 m de luz, salvo uno, levadizo, que tiene 40 m. La altura libre sobre las ag^uas del mar es de 15 m, que es insuficiente para las naves de gran tonelaje; esto exigió que uno de sus tramos, en aguas

  17. Discursos sobre la identidad como recurso adaptativo entre inmigrantes colombianos en Europa

    Directory of Open Access Journals (Sweden)

    Gregorio Hernández Pulgarín

    2016-01-01

    Full Text Available Este artículo busca comprender el papel de los discursos que integran la identidad nacional en el proceso de adaptación en condiciones límite de inmigrantes colom - bianos en Europa. El abordaje, parte de un estudio etnográfico de colombianos inmigrantes por razones económicas en Bordeaux, Francia y Sevilla, España en di - ferentes períodos, de 2006 a 2012, y de la aplicación de entrevistas a migrantes colombianos en ambos países, retornados a Pereira, Colombia. Los resultados ob - tenidos muestran que en las situaciones límite, los inmigrantes colombianos suelen responder a los retos del proceso de adaptación, basados en discursos sobre la iden - tidad nacional que producen un efecto performativo con consecuencias favorables para la concepción de sí mismos, para la adaptación a las circunstancias adversas y para continuar el proyecto migratorio.

  18. Cesium-137 global fallout into the Ob river basin and its influence on the Kara sea contamination - Weapons fallout cesium-137 in the Ob' catchment landscapes and its influence on radioactive contamination of the Kara sea: Western Siberia, Russia

    Energy Technology Data Exchange (ETDEWEB)

    Semenkov, Ivan N.; Miroshnikov, Alexey Yu. [The Organization of Russian Academy of Sciences Institute of geology of ore deposits, petrography, mineralogy and geochemistry Russian Academy of Sciences (Russian Federation)

    2014-07-01

    There are several high level {sup 137}Cs anomaly zones detected in the deposits of the SW part of the Kara Sea. These anomaly zones were formed in the Ob' and the Enisey river estuaries due to the geochemical 'river-sea' boarder barrier. Level of radiocaesium specific activity reaches 120 Bq*kg{sup -1} in the deposits from these zones. Radiochemical enterprises occur in the both river basins. Their activity results in caesium-137 transfer into the river net. Vast area is contaminated by {sup 137}Cs after nuclear weapons in Semipalatinsk test-site and Kyshtym disaster in the Ob' river basin. Moreover, caesium comes to the Ob' and the Enisey river basins with global atmospheric fallout. The inflow of global fallout caesium-137 to the catchments is 660 kCi (320 kCi including radioactive decay) that is 4 times higher than {sup 137}Cs emission due to Fukushima disaster. Therefore, these river basins as any other huge catchment are an important sources of radioactive contamination of the Arctic Ocean. The aim of our research is to study behavior of global fallout caesium-137 in the landscapes of the Ob and the Enisey river basins. We studied caesium-137 behavior on the example of first order catchments in taiga, wetland, forest-steppe, steppe, and semi-arid landscapes. Geographic information system (GIS) was made. The tenth-order catchments (n=154, Horton coding system) shape 20-groups due to topsoil properties controlling cesium mobility. Eleven first-order basins, characterized 7 groups of tenth order catchments, were studied. And 700 bulk-core soil samples were collected in 2011-2013. Cesium runoff is calculated for 3 first-order river basins in taiga and forest-steppe landscapes. Storage of global fallout caesium-137 declines from undisturbing taiga first-order river basin (90% of cumulative fallout including radioactive decay)> arable steppe and fores-steppe (70 - 75%)> undisturbing wetland (60%). Caesium-137 transfer is high in arable lands

  19. Somos un envase : Discursos sobre el aborto

    OpenAIRE

    Löcher, Jennifer Irene

    2014-01-01

    No hay persona que no tenga opinión acerca del asunto y, cada vez más, la sociedad argentina debate sobre la pregunta de si se debe legalizar/despenalizar el aborto o no. Nunca antes se habló tanto sobre el tema públicamente: se publican artículos en los diarios, hay manifestaciones a favor y hay manifestaciones en contra de la legalización del aborto. El siguiente trabajo pretende relevar y analizar discursos que circulan socialmente alrededor del debate sobre el aborto. (Párrafo extraíd...

  20. Cooperative Hurricane Network Obs

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Observations from the Cooperative Hurricane Reporting Network (CHURN), a special network of stations that provided observations when tropical cyclones approached the...

  1. The OBS control plane

    DEFF Research Database (Denmark)

    Manolova, Anna Vasileva; Ruepp, Sarah Renée

    2010-01-01

    . The applicability analysis carried out here focuses on the actual feasibility of the integration and the potential trade-offs which appear when two contradicting principles are combined. Taking advantage of the flexibility of the GMPLS control plane does not seem to be as easy and as straightforward as expected...

  2. ANCEIOct-ob-er

    Indian Academy of Sciences (India)

    work of Neumark [2], a British aeronautical engineer, which was published as early as 1965, but not ... You have raised a question that I have always been asking me whenever I get the current ... me want to show off their scholarship and assume the readers know the subject. I used to get ... keep myself away. Resonance is ...

  3. Ob padcu utopije

    Directory of Open Access Journals (Sweden)

    Pascal De Decker

    2009-01-01

    Full Text Available Po koncu 2. svetovne vojne so se začele graditi velike stanovanjske soseske. Pogosto so jih sestavljale stolpnice. Številne le 50 let pozneje podirajo oziroma jih temeljito prenavljajo. Modernistične ideje, ki so jih navdihnili predstavniki kongresa CIAM (Congrès International d’Architecture Moderne in Le Corbusier, so izgubile nekdanjo mikavnost. V tem prispevku si bomo ogledali razvoj dogodkov, predvsem pa se bomo posvetili napačni razlagi (simbolnega pomena bivališča, kakor so ga razumeli predstavniki modernističnega gibanja. Prav to napačno razumevanje je nazadnje pripeljalo do hitrega podiranja teh sosesk.

  4. Estudo multicasos sobre atividades inovativas

    Directory of Open Access Journals (Sweden)

    Sonia Regina Hierro Parolin

    2013-09-01

    Full Text Available Em estudos sobre competitividade argumenta-se que as empresas necessitam de estratégias baseadas em inovações e de capacidades internas em constantes e intensas transformações, não somente nos padrões tecnológicos, mas também no encadeamento do processo de gestão das atividades inovativas, como processos dinâmicos, não lineares e diversificados, em função de múltiplos fatores dos ambientes interno e externo. Para contribuir com essas discussões, neste artigo apresenta-se um estudo multicasos em quatro indústrias de médio e grande portes, de segmentos, densidades tecnológicas e históricos com inovações diferentes entre si. Como principais resultados, salientam-se o encadeamento das atividades inovativas como parte de uma estratégia organizacional para obter resultados com inovação e a afluência de todas as pessoas, e não somente as alocadas em pesquisa e desenvolvimento, para o cumprimento dessa estratégia.

  5. Notas sobre publicaciones medievales portuguesas

    Directory of Open Access Journals (Sweden)

    José Luis MARTÍN

    2009-11-01

    Full Text Available Contra lo que debiera suceder, la proximidad con Portugal no incita al conocimiento de su historia y son muy raros los manuales de Historia de España en los que se concede a la Edad Media Portuguesa la importancia que realmente tiene, y en los tratados de Historia Medieval Europea el espacio dedicado a Portugal es mínimo, al menos hasta la época de los Descubrimientos; por otra parte, son contados los medievalistas españoles que se interesan por la historia de Portugal. Ante estos silencios y ante la escasa presencia en las bibliotecas españolas de obras portuguesas el estudiante de historia puede pensar que el país vecino carece de medievalistas de relieve, que su historia medieval está por hacer... y nada más lejos de la realidad como intentaré probar en este breve comentario, sin ánimo exhaustivo, sobre algunas de las últimas publicaciones aparecidas en Portugal.

  6. Los derechos de autor sobre obtenciones vegetales

    Directory of Open Access Journals (Sweden)

    Rosario Silva Gilli

    2015-01-01

    Full Text Available Contenido: Las creaciones en la agricultura. Los derechos de autor sobre obtenciones vegetales. El Convenio Internacional para la protección de las obtenciones vegetales (París 1961 y sus revisiones de Ginebra 1972, 1978,1991 Objeto de la protección legal. Condiciones del cultivar. Alcance de la protección. La protección de obtenciones vegetales en el Mercosur. Los Derechos de autor en el Mercosur. El Protocolo de Armonización de normas sobre Propiedad Intelectual en el Mercosur. El Acuerdo de Cooperación y facilitación sobre la protección de las obtenciones vegetales en los Estados Partes del Mercosur.  Alcance de la normativa Mercosur. Los Derechos sobre cultivares en Uruguay. Los Derechos de autor como derechos humanos. ¿Derechos de autor vs. derecho de propiedad intelectual? Reflexión final

  7. Star formation history of Canis Major OB1. II. A bimodal X-ray population revealed by XMM-Newton

    Science.gov (United States)

    Santos-Silva, T.; Gregorio-Hetem, J.; Montmerle, T.; Fernandes, B.; Stelzer, B.

    2018-02-01

    Aims: The Canis Major OB1 Association has an intriguing scenario of star formation, especially in the region called Canis Major R1 (CMa R1) traditionally assigned to a reflection nebula, but in reality an ionized region. This work is focussed on the young stellar population associated with CMa R1, for which our previous results from ROSAT, optical, and near-infrared data had revealed two stellar groups with different ages, suggesting a possible mixing of populations originated from distinct star formation episodes. Methods: The X-ray data allow the detected sources to be characterized according to hardness ratios, light curves, and spectra. Estimates of mass and age were obtained from the 2MASS catalogue and used to define a complete subsample of stellar counterparts for statistical purposes. Results: A catalogue of 387 XMM-Newton sources is provided, of which 78% are confirmed as members or probable members of the CMa R1 association. Flares (or similar events) were observed for 13 sources and the spectra of 21 bright sources could be fitted by a thermal plasma model. Mean values of fits parameters were used to estimate X-ray luminosities. We found a minimum value of log(LX [erg/s] ) = 29.43, indicating that our sample of low-mass stars (M⋆ ≤ 0.5 M⊙), which are faint X-ray emitters, is incomplete. Among the 250 objects selected as our complete subsample (defining our "best sample"), 171 are found to the east of the cloud, near Z CMa and dense molecular gas, of which 50% of them are young (10 Myr). The opposite happens to the west, near GU CMa, in areas lacking molecular gas: among 79 objects, 30% are young and 50% are older. These findings confirm that a first episode of distributed star formation occurred in the whole studied region 10 Myr ago and dispersed the molecular gas, while a second, localized episode (<5 Myr) took place in the regions where molecular gas is still present.

  8. Conocimientos sobre incontinencia urinaria en pacientes hospitalizados

    Directory of Open Access Journals (Sweden)

    Otto Guillen Lopez

    2003-10-01

    Full Text Available Objetivo: Determinar el nivel de conocimientos sobre incontinencia urinaria (IU en pacientes hospitalizados. Material y métodos: Estudio transversal, descriptivo; se entrevistó una muestra por saturación de 325 pacientes hospitalizados de 30 años a más del Hospital Nacional Cayetano Heredia (HNCH, Lima - Perú, utilizando un cuestionario de conocimientos sobre incontinencia, considerándose como adecuado conocimiento cuando había más de 50% de aciertos en él. Resultados: Solamente 35.7% tuvieron conocimiento adecuado sobre IU. Hasta 90% conocía acerca del éxito del tratamiento y posibilidad de curación de los pacientes incontinentes. Sin embargo, 75% consideraron erróneamente que la IU era consecuencia inevitable del envejecimiento, mientras menos de 50% de pacientes conocía el papel de ciertos medicamentos y ejercicios en la IU. Conclusiones: Se demostró un pobre conocimiento general sobre la IU, siendo necesaria una intervención de los profesionales de la salud en la educación de la población, sobre todo hospitalizada y con factores predisponentes para desarrollar IU, para así poder modificar las ideas erróneas que existen sobre el tema. (Rev Med Hered 2003; 14: 186-194.

  9. The distribution and history of nuclear weapons related contamination in sediments from the Ob River, Siberia as determined by isotopic ratios of plutonium and neptunium

    International Nuclear Information System (INIS)

    Kenna, T.C.; Sayles, F.L.

    2002-01-01

    Isotopic ratios of Pu and Np measured in sediment cores from 5 locations in the Ob River drainage basin show clear evidence of input from sources other than global fallout (non-fallout sources). Historical contaminant records obtained by combining isotopic ratio information with chronological information indicate that non-fallout inputs are from several sources that have varied significantly over the past 50 years. Unique isotopic signatures observed in sediments from tributaries that drain areas containing known or suspected sources of non-fallout contamination are used to identify the source of materials in sediments collected at downstream locations. These data can lead to a better understanding of the transport behavior, fate, and relative importance of particle reactive, weapons related contaminants originating from the nuclear facilities Mayak, Tomsk-7, and Semipalitinsk, which lie within the drainage basin. From our work to date, we draw the following conclusions: (1) Persistent non-fallout contamination is observed in the Ob River above its confluence with the Irtysh River, indicating contamination from the Tomsk-7 facility. (2) Non-fallout contamination in the Tobol River above its confluence with the Irtysh River indicates contamination from the Mayak facility. (3) Non-fallout contamination in the Irtysh River above its confluence with the Tobol River indicates contamination from the Semipalitinsk weapons test site. (4) The occurrence of isotopic ratios in Ob Delta sediments that are similar to those observed in source tributaries suggests that contamination from at least two sources has been transported along the length of the river system. (5) Global fallout, a result of high-yield atmospheric weapons tests conducted by the FSU and USA primarily, is the dominant source of Pu and Np to the region; however, there have been brief periods when inputs from non-fallout sources exceeded those from global fallout

  10. The history and source of particulate 137Cs and 239,240Pu deposition in sediments of the Ob River Delta, Siberia

    International Nuclear Information System (INIS)

    Sayles, F.L.; Livingston, H.D.; Panteleyev, G.P.

    1997-01-01

    This paper presents the first results of a project designed to examine the transfer of particle-associated artificial radionuclides down the Ob River in Siberia to its delta over the past 5 decades. The main sources include fallout from atmospheric nuclear weapons tests and weapons complexes and test sites of the Former Soviet Union in or near the Ob watershed. The approach is to measure the accumulation of the radionuclides in undisturbed delta sediments - obtaining a record of their deposition over time. These records were found in sediments of shallow lakes apart from, and connected to, the main channel. Sediment cores were collected in the summer of 1994 using a shallow draft catamaran to reach these lakes from a support ship in the main channel. Measurements are presented on the depth distributions of 137 Cs and Pu isotopes and their inventories in a series of dated sediment cores - including one from a location in the Taz Estuary (which does not receive Ob River sediments). Sediment dating was carried out using the excess 210 Pb technique. The results obtained are compared with known information on the temporal history of releases from the various sources and characteristics of the isotopic composition of the sources. The results show that good records of radionuclide deposition indicate that the major fraction of 137 Cs and Pu isotopes deposited in these delta sediments comes from atmospheric nuclear weapons test fallout - both delivered directly from the atmosphere and from downstream transport of watershed sediments. No more than 25% of the observed inventories could be derived from other sources

  11. PERSPECTIVAS INFANTILES SOBRE LA TERRITORIALIDAD

    Directory of Open Access Journals (Sweden)

    NOELIA ENRIZ

    2009-12-01

    Full Text Available In this paper we propose a different approach to children's ideas about the geographical area in the particular context of the Mbyá Guarani population, from Misiones (Argentine. The territorial fragility, that is exposed to the indigenous people in Argentina aremanifested daily in several areas. Mbyá population, has been crossed by the boundaries of national states of Paraguay, Brazil and Argentina. The sedentary and enclosures land processes in different states, have prompted changes in the logic of subsistence, housing and community organization. In Misiones province case, bureaucratic accreditation of land titles is postponed, the state is not committed to the realization of this right.RESUMEN: En este trabajo nos proponemos un acercamiento a las diversas ideas infantiles sobre el territorio habitado, en el contexto particular de la población mbyá guaraní de Misiones. La fragilidad territorialidad a la que es expuesta la población indígena en Argentina se manifiestan cotidianamente en diversas áreas. La población mbyá, ha sido surcada por los límites de los estados nacionales de Paraguay, Brasil y Argentina. La sedentarización y los cercamientos de tierras en los diferentes estados, han impulsado transformaciones de las lógicas de subsistencia, de habitación y organización comunitaria. En el caso de la provincia de Misiones la acreditación burocrática de los títulos de tierras se encuentra aplazada, el estado no se compromete con la concreción de este derecho.

  12. Consideraciones preliminares sobre la credibilidad

    Directory of Open Access Journals (Sweden)

    Fernando Verdugo

    2004-01-01

    Full Text Available A modo de introducción al Seminario Interno de Profesores de la Facultad de Teología de la PUC, el autor recuerda, en primer lugar, lo que suele entenderse por "credibilidad" y, también, algunos de los criterios generales por los cuales algo o alguien adquiere la calidad de creíble (el que sea razonable, relevante o significativo, capaz de producir gozo estético, etc.. Luego, en la parte más extensa, el autor vuelve a llamar la atención sobre la necesidad de atender a los condicionamientos culturales de la fe cristiana. La fe, al igual que toda experiencia humana, está culturalmente mediada. Tomar conciencia de ese hecho y asumir las consecuencias metodológicas es indispensable para una teología que quiere poner atención a los desafíos actuales y contribuir así a la credibilidad del cristianismoThis article reprints the introductory session to the internal seminar of lecturers from the Faculty of Theology of the UC. In the first place, the author sums up what is usually understood by `credibility' and the general criteria through which something or someone gains credibility (being reasonable, relevant or significant, capable of producing aesthetic pleasure. Then the author deals at length with the need to take notice of the cultural conditionings of the Christian faith. The faith, the same as any other human experience, is culturally mediated. It is crucial for theology to become aware of this fact and come to terms with its methodological consequences, if it wants to face current challenges and so contribute to the credibility of Christianity

  13. Estudios sobre la reactividad de harinas crudas de cemento tratadas con rápidos y diferentes calentamientos

    Directory of Open Access Journals (Sweden)

    Weisweiler, W.

    1988-09-01

    Full Text Available Not available.

    Estudios experimentales llevados a cabo a una temperatura dada de calcinación, sirvieron para observar el efecto de las altas velocidades de calentamiento sobre las reacciones del clinker. Mientras que un aumento de la reactividad de los materiales fue claramente detectada cuando la velocidad pasó de 20 K/min a tomar valores iguales y mayores a 100 K/min, un negativo efecto sobre el Tiempo de Reacción Completa o "Período de Calcinación a Punto" no pudo ser establecido. Considerando además que el tiempo necesario para llevar a la materia prima hasta la temperatura de reacción, es necesariamente un tiempo inefectivo, podrían las plantas productoras de cemento obtener mayores rendimientos en tiempo y espacio, utilizando altas cuotas de calentamiento. Estudios de microscopía probaron que con el aumento de las velocidades de calentamiento, hubo una mayor generación de microcristales incidiendo directamente sobre la molienda y calidad del clinker. [de] Untersuchungen zur Reaktivität van zementrohmehlen nach verschieden schneller Aufheizung. Modellversuche mit linearen Aufheizgeschwindigkeiten solten zeigen, ob bei einer vorgegebenen Brenntemperatur die Verklinkerungsreaktionen beeinfluβt werden können. Während eindeutige Steigerungen der Kalkbindungsraten lediglich zwischen 20 K/min und Aufheizgeschwindigkeiten >=100 K/min nachweisbar waren, konnten negative Auswirkungen auf die Garbranddauern bei keiner Versuchsserie festgestellt werden. Unter Berücksichtigung der zur Aufheizung der Rohstoffe notwendigen Totzeiten, können bei den technischen Zementproduktionsanlagen nach schneller Aufheizung höhere Raum-Zeit-Ausbeuten erreicht werden. Mikroskopische Untersuchungen ergaben, daβ durch Erhöhung der Aufheizraten der Anteil mikrokristalliner Klinkerphasen zunimmt, was sich direkt aut die Zementklinkermahibarkeit und die Klinkerqualität aswirkt.

  14. Efecto del beneficiado de mezclas de variedades de arroz sobre variables de rendimiento molinero

    Directory of Open Access Journals (Sweden)

    Manuel Zeled\\u00F3n-Grau

    2007-01-01

    Full Text Available Efecto del beneficiado de mezclas de variedades de arroz sobre variables de rendimiento molinero. Con el fin de determinar si las variables de rendimiento molinero del arroz (rendimiento de molino, rendimiento de arroz co mer cial e ín di ce de pi la da se afec tan cuan do una va rie dad se be ne fi cia en mez cla con otras, en el Cen tro de In vestigacio nes en Gra nos y Se mi llas (CIGRAS se eva lua ron cua tro mez clas de las tres va rie da des más uti li za das en Cos ta Ri ca en la co se cha 1999-2000 (CR-1113, CR-5272 y Se te sa-9. Otras variables analizadas fueron los por centajes de: grano quebrado, grano quebrado grueso, puntilla, semolina (salvado de arroz, se mo li na pu ra y cas carilla en la semolina. Para cada variable se calculó un índice (Im que ex presa qué tanto el va lor ob te ni do se des vió del va lor esperado para cada una de las mez clas (es pe ra do = pro me dio de los re sultados individua les para cada variedad cuando se la pro cesó sin mezclar. No se encontraron diferencias significativas entre los índices de los tra ta mien tos eva lua dos. Sin em bar go, se ob ser vó un efecto detrimental en las variables de rendimiento molinero de las mez clas en que par ti ci pó CR 5272. Con tra rio a es to, la mezcla CR-1113-Setesa-9 mostró un efecto beneficioso. Los efectos detrimentales observados con el beneficiado de las mez clas fue ron atri bui dos a una ma yor pro duc ción que la esperada de puntilla y de pedazos muy pequeños de arroz en la se mo li na. Por su par te, en la mez cla en la que se re gis tró un efecto beneficioso hubo una menor producción que la esperada de se molina pura y de quebrado grueso. La pérdida económica que causaría la mezcla más perjudicial fue estimada en $ 1 por to ne la da mé tri ca.

  15. Consenso mexicano sobre la dispepsia

    Directory of Open Access Journals (Sweden)

    R. Carmona-Sánchez

    2017-10-01

    Full Text Available Desde la publicación de las guías de dispepsia 2007 de la Asociación Mexicana de Gastroenterología ha habido avances significativos en el conocimiento de esta enfermedad. Se realizó una revisión sistemática de la literatura en PubMed (01/2007 a 06/2016 con el fin de revisar y actualizar las guías 2007 y proporcionar nuevas recomendaciones basadas en evidencia. Se incluyeron todas las publicaciones en español e inglés, de alta calidad. Se redactaron enunciados que fueron votados utilizando el método Delphi. Se estableció la calidad de la evidencia y la fuerza de las recomendaciones según el sistema GRADE para cada enunciado. Treinta y un enunciados fueron redactados, votados y calificados. Se informan nuevos datos sobre definición, clasificación, epidemiología y fisiopatología. La endoscopia debe realizarse en dispepsia no investigada cuando hay datos de alarma o falla al tratamiento. Las biopsias gástricas y duodenales permiten confirmar infección por Helicobacter pylori y excluir enfermedad celiaca, respectivamente. Establecer una fuerte relación médico-paciente, cambios en la dieta y en el estilo de vida son útiles como medidas iniciales. Los bloqueadores H2, inhibidores de la bomba de protones, procinéticos y fármacos antidepresivos son efectivos. La erradicación de H. pylori puede ser eficaz en algunos pacientes. Con excepción de Iberogast y rikkunshito, las terapias complementarias y alternativas carecen de beneficio. No existe evidencia con respecto a la utilidad de prebióticos, probióticos o terapias psicológicas. Los nuevos enunciados proporcionan directrices basadas en la evidencia actualizada. Se presenta la discusión, el grado y la fuerza de la recomendación de cada uno de ellos.

  16. ECA&D and E-OBS: High-resolution datasets for monitoring climate change and effects on viticulture in Europe

    Directory of Open Access Journals (Sweden)

    Photiadou Christiana

    2017-01-01

    Full Text Available Climate change and climate variability profoundly affect the production of wine. When facing a changing climate, the characteristics of wine produced in each region will change while the natural year-to-year variations in climate will increase variability of income for wine businesses and therefore affect profitability and economic resilience. The challenge posed to the viticulture community is thus to closely monitor these changes to be able to adapt business practices. The European Climate Assessment and Dataset (ECA&D and its gridded version E-OBS are tools to monitor the changing climatic conditions over Europe, with an emphasis on changes in extreme climatic conditions. In this paper, the potential of ECA&D and E-OBS for viticulture is demonstrated by a few examples. The examples include the changing areal suitable for Chardonnay cultivation, showing an expansion to areas which have been too cold only a few decades ago and retraction of optimal conditions from areas which have been suitable in the recent past. Other examples show the change in the diurnal temperature range in the latter stages of the ripening process of grapes and the variability in heavy precipitation events. Finally, first results of a new dataset for South America are presented.

  17. Acoustic and Shear-Wave Velocities in Hydrate-Bearing Sediments Offshore Southwestern Taiwan: Tomography, Converted Waves Analysis and Reverse-Time Migration of OBS Records

    Directory of Open Access Journals (Sweden)

    Philippe Schnurle

    2006-01-01

    Full Text Available A 2.5-D combined seismic reflection and refraction survey has been conducted in the accretionary complex offshore of southwestern Taiwan where BSRs (Bottom Simulating Reflectors are highly concentrated and geochemical signals for the presence of gas hydrate are strong. In this study, we perform velocity analysis of the 6 4-component OBS (Ocean-Bottom Seismometer records along the southernmost transect of this seismic experiment. We utilize 3 independent methods in order to accurately determine the acoustic and shear-wave velocities of the sediments: 1-D Root Mean Square (RMS analysis of the P-P and P-S reflected events on individual datumed components, 2-D inversion of the P-P and P-S reflected and refracted events along the in-line transect, and 3-D acoustic inversion of the first arrivals. The principal sources of bias in the determination of the velocities are the 3-dimentional nature of the topography and the complexity of the underlying structures. The three methods result in consistent velocity profiles. Rapid lateral and vertical variations of the velocities are observed. We then investigate the large scale gas hydrate content through rock physic modeling: at the vertical of each OBS, shear-waves velocities are utilized to estimate the water-filled porosities, and the acoustic velocities predicted for a set of gas hydrate, quartz and clay contents are compared to the observed profiles.

  18. MULTI-EPOCH VERY LONG BASELINE ARRAY OBSERVATIONS OF THE COMPACT WIND-COLLISION REGION IN THE QUADRUPLE SYSTEM Cyg OB2 no. 5

    Energy Technology Data Exchange (ETDEWEB)

    Dzib, Sergio A.; Rodriguez, Luis F.; Loinard, Laurent; Ortiz-Leon, Gisela N.; Araudo, Anabella T. [Centro de Radiostronomia y Astrofisica, Universidad Nacional Autonoma de Mexico, Morelia 58089 (Mexico); Mioduszewski, Amy J., E-mail: s.dzib@crya.unam.mx [National Radio Astronomy Observatory, 1003 Lopezville Road, Socorro, NM 87801 (United States)

    2013-02-15

    We present multi-epoch Very Long Base Array observations of the compact wind-collision region in the Cyg OB2 no. 5 system. These observations confirm the arc-shaped morphology of the emission reported earlier. The total flux as a function of time is roughly constant when the source is 'on', but falls below the detection limit as the wind-collision region approaches periastron in its orbit around the contact binary at the center of the system. In addition, at one of the 'on' epochs, the flux drops to about a fifth of its average value. We suggest that this apparent variation could result from the inhomogeneity of the wind that hides part of the flux rather than from an intrinsic variation. We measured a trigonometrical parallax, for the most compact radio emission of 0.61 {+-} 0.22 mas, corresponding to a distance of 1.65 {sup +0.96} {sub -0.44} kpc, in agreement with recent trigonometrical parallaxes measured for objects in the Cygnus X complex. Using constraints on the total mass of the system and orbital parameters previously reported in the literature, we obtain two independent indirect measurements of the distance to the Cyg OB2 no. 5 system, both consistent with 1.3-1.4 kpc. Finally, we suggest that the companion star responsible for the wind interaction, yet undetected, is of spectral type between B0.5 and O8.

  19. MULTI-EPOCH VERY LONG BASELINE ARRAY OBSERVATIONS OF THE COMPACT WIND-COLLISION REGION IN THE QUADRUPLE SYSTEM Cyg OB2 no. 5

    International Nuclear Information System (INIS)

    Dzib, Sergio A.; Rodríguez, Luis F.; Loinard, Laurent; Ortiz-León, Gisela N.; Araudo, Anabella T.; Mioduszewski, Amy J.

    2013-01-01

    We present multi-epoch Very Long Base Array observations of the compact wind-collision region in the Cyg OB2 no. 5 system. These observations confirm the arc-shaped morphology of the emission reported earlier. The total flux as a function of time is roughly constant when the source is 'on', but falls below the detection limit as the wind-collision region approaches periastron in its orbit around the contact binary at the center of the system. In addition, at one of the 'on' epochs, the flux drops to about a fifth of its average value. We suggest that this apparent variation could result from the inhomogeneity of the wind that hides part of the flux rather than from an intrinsic variation. We measured a trigonometrical parallax, for the most compact radio emission of 0.61 ± 0.22 mas, corresponding to a distance of 1.65 +0.96 –0.44 kpc, in agreement with recent trigonometrical parallaxes measured for objects in the Cygnus X complex. Using constraints on the total mass of the system and orbital parameters previously reported in the literature, we obtain two independent indirect measurements of the distance to the Cyg OB2 no. 5 system, both consistent with 1.3-1.4 kpc. Finally, we suggest that the companion star responsible for the wind interaction, yet undetected, is of spectral type between B0.5 and O8.

  20. DISERTACIÓN SOBRE JUSTICIA Y EQUIDAD

    Directory of Open Access Journals (Sweden)

    Sayuri P. Tamura M.

    2001-01-01

    Full Text Available «Disertación sobre equidad y justicia» es básicamente una respuesta a una inquietud en particular que yo tenía sobre las distintas posiciones que existen sobre estos dos temas y cómo definir cuál es la más acertada. Hice una descripción del punto de vista de Amartya Sen –la violación de los derechos sobre la propiedad privada es justificable si evitan las hambrunas2– frente al de Robert Nozick –la propiedad privada es un derecho fundamental y como tal debe ser respetado3–, sin embargo, aunque ambos enfoques son totalmente contrarios tienen mucho sentido, por lo cual es bastante difícil decidirse por uno en particular. Fue de esta forma, enfrentando sus opiniones, que yo logré desarrollar una posición frente a estas dos perspectivas, y así dar mi opinión al DISERTACIÓN SOBRE JUSTICIA Y EQUIDAD SAYURI P. TAMURA M. Estudiante de Economía y Negocios Internacionales de la Universidad ICESI. respecto. Al final, llegué a una conclusión, que aunque no es la más original y tampoco es la única, tiene mucho sentido y seguramente de ser posible, la situación del país podría cambiar para bien.

  1. Impuesto sobre las transacciones financieras: Justicia fiscal

    OpenAIRE

    Mariño, José Ramón

    2016-01-01

    7 p.[Variante del título de la publicación : Boletín electrónico de Hegoa] [ESP] El Impuesto sobre las transacciones financieras se basa en establecer un gravamen sobre las operaciones financieras con el fin de estabilizar los mercados como consecuencia de la disminución de la especulación a corto plazo. Además es una fuente de financiación de inversiones socialmente deseables. Diez países de la Unión Europea han expresado su deseo de introducir el ITF, sin emba...

  2. Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain

    Directory of Open Access Journals (Sweden)

    Shanmugam M Jeyakumar

    2016-01-01

    Full Text Available Background & objectives: Hepatic scavenger receptor class B1 (SR-B1, a high-density lipoprotein (HDL receptor, is involved in the selective uptake of HDL-associated esterified cholesterol (EC, thereby regulates cholesterol homoeostasis and improves reverse cholesterol transport. Previously, we reported in euglycaemic obese rats (WNIN/Ob strain that feeding of vitamin A-enriched diet normalized hypercholesterolaemia, possibly through hepatic SR-B1-mediated pathway. This study was aimed to test whether it would be possible to normalize hypercholesterolaemia in glucose-intolerant obese rat model (WNIN/GR/Ob through similar mechanism by feeding identical vitamin A-enriched diet. Methods: In this study, 30 wk old male lean and obese rats of WNIN/GR-Ob strain were divided into two groups and received either stock diet or vitamin A-enriched diet (2.6 mg or 129 mg vitamin A/kg diet for 14 wk. Blood and other tissues were collected for various biochemical analyses. Results: Chronic vitamin A-enriched diet feeding decreased hypercholesterolaemia and normalized abnormally elevated plasma HDL-cholesterol (HDL-C levels in obese rats as compared to stock diet-fed obese groups. Further, decreased free cholesterol (FC and increased esterified cholesterol (EC contents of plasma cholesterol were observed, which were reflected in higher EC to FC ratio of vitamin A-enriched diet-fed obese rats. However, neither lecithin-cholesterol acyltransferase (LCAT activity of plasma nor its expression (both gene and protein in the liver were altered. On the contrary, hepatic cholesterol levels significantly increased in vitamin A-enriched diet fed obese rats. Hepatic SR-B1 expression (both mRNA and protein remained unaltered among groups. Vitamin A-enriched diet fed obese rats showed a significant increase in hepatic low-density lipoprotein receptor mRNA levels, while the expression of genes involved in HDL synthesis, namely, ATP-binding cassette protein 1 (ABCA1 and

  3. THE BOLOCAM GALACTIC PLANE SURVEY. III. CHARACTERIZING PHYSICAL PROPERTIES OF MASSIVE STAR-FORMING REGIONS IN THE GEMINI OB1 MOLECULAR CLOUD

    International Nuclear Information System (INIS)

    Dunham, Miranda K.; Evans, Neal J.; Harvey, Paul; Merello, Manuel; Rosolowsky, Erik; Cyganowski, Claudia J.; Aguirre, James; Bally, John; Battersby, Cara; Ginsburg, Adam; Glenn, Jason; Stringfellow, Guy S.; Bradley, Eric Todd; Dowell, Darren; Drosback, Meredith; Schlingman, Wayne; Shirley, Yancy L.; Walawender, Josh; Williams, Jonathan P.

    2010-01-01

    We present the 1.1 mm Bolocam Galactic Plane Survey (BGPS) observations of the Gemini OB1 molecular cloud complex, and targeted NH 3 observations of the BGPS sources. When paired with molecular spectroscopy of a dense gas tracer, millimeter observations yield physical properties such as masses, radii, mean densities, kinetic temperatures, and line widths. We detect 34 distinct BGPS sources above 5σ = 0.37 Jy beam -1 with corresponding 5σ detections in the NH 3 (1,1) transition. Eight of the objects show water maser emission (20%). We find a mean millimeter source FWHM of 1.12 pc and a mean gas kinetic temperature of 20 K for the sample of 34 BGPS sources with detections in the NH 3 (1,1) line. The observed NH 3 line widths are dominated by non-thermal motions, typically found to be a few times the thermal sound speed expected for the derived kinetic temperature. We calculate the mass for each source from the millimeter flux assuming the sources are isothermal and find a mean isothermal mass within a 120'' aperture of 230 ± 180 M sun . We find a total mass of 8400 M sun for all BGPS sources in the Gemini OB1 molecular cloud, representing 6.5% of the cloud mass. By comparing the millimeter isothermal mass to the virial mass calculated from the NH 3 line widths within a radius equal to the millimeter source size, we find a mean virial parameter (M vir /M iso ) of 1.0 ± 0.9 for the sample. We find mean values for the distributions of column densities of 1.0 x 10 22 cm -2 for H 2 , and 3.0 x 10 14 cm -2 for NH 3 , giving a mean NH 3 abundance of 3.0 x 10 -8 relative to H 2 . We find volume-averaged densities on the order of 10 3 -10 4 cm -3 . The sizes and densities suggest that in the Gem OB1 region the BGPS is detecting the clumps from which stellar clusters form, rather than smaller, higher density cores where single stars or small multiple systems form.

  4. Gels and gel-derived glasses in the Na2O-B2O3-SiO2 system. [containerless melting in space

    Science.gov (United States)

    Mukherjee, S. P.

    1982-01-01

    The containerless melting of high-purity multicomponent homogeneous gels and gel-monoliths offers a unique approach to making ultrapure multicomponent optical glasses in the reduced gravity environment of space. Procedures for preparing and characterizing gels and gel-derived glasses in the Na2O-B2O3-SiO2 system are described. Preparation is based on the polymerization reactions of alkoxysilane with trimethyl borate or boric acid and a suitable sodium compound. The chemistry of the gelling process is discussed in terms of process parameters and the gel compositions. The physicochemical nature of gels prepared by three different procedures were found to be significantly different. IR absorption spectra indicate finite differences in the molecular structures of the different gels. The melting of the gel powders and the transformation of porous gel-monoliths to transparent 'glass' without melting are described.

  5. Gels and gel-derived glasses in the system Na2O-B2O3-SiO2

    Science.gov (United States)

    Mukherjee, S. P.

    1983-01-01

    The containerless melting of high-purity multicomponent homogeneous gels and gel monoliths offers a unique approach to making ultrapure multicomponent optical glasses in the reduced gravity environment of space. Procedures for preparing and characterizing gels and gel-derived glasses in the system Na2O-B2O3-SiO2 are described. Preparation is based on the polymerization reactions of alkoxysilane with trimethyl borate or boric acid and a suitable sodium compound. The chemistry of the gelling process is discussed in terms of process parameters and the gel compositions. The physicochemical nature of gels prepared by three different procedures was found to be significantly different. Infrared absorption spectra indicate finite differences in the molecular structures of the different gels. The melting of the gel powders and the transformation of porous gel monoliths to transparent 'glass' without melting are described.

  6. DUST PROPERTIES AND DISK STRUCTURE OF EVOLVED PROTOPLANETARY DISKS IN Cep OB2: GRAIN GROWTH, SETTLING, GAS AND DUST MASS, AND INSIDE-OUT EVOLUTION

    International Nuclear Information System (INIS)

    Sicilia-Aguilar, Aurora; Henning, Thomas; Dullemond, Cornelis P.; Bouwman, Jeroen; Sturm, Bernhard; Patel, Nimesh; Juhász, Attila

    2011-01-01

    We present Spitzer/Infrared Spectrograph spectra of 31 T Tauri stars (TTS) and IRAM/1.3 mm observations for 34 low- and intermediate-mass stars in the Cep OB2 region. Including our previously published data, we analyze 56 TTS and 3 intermediate-mass stars with silicate features in Tr 37 (∼4 Myr) and NGC 7160 (∼12 Myr). The silicate emission features are well reproduced with a mixture of amorphous (with olivine, forsterite, and silica stoichiometry) and crystalline grains (forsterite, enstatite). We explore grain size and disk structure using radiative transfer disk models, finding that most objects have suffered substantial evolution (grain growth, settling). About half of the disks show inside-out evolution, with either dust-cleared inner holes or a radially dependent dust distribution, typically with larger grains and more settling in the innermost disk. The typical strong silicate features nevertheless require the presence of small dust grains, and could be explained by differential settling according to grain size, anomalous dust distributions, and/or optically thin dust populations within disk gaps. M-type stars tend to have weaker silicate emission and steeper spectral energy distributions than K-type objects. The inferred low dust masses are in a strong contrast with the relatively high gas accretion rates, suggesting global grain growth and/or an anomalous gas-to-dust ratio. Transition disks in the Cep OB2 region display strongly processed grains, suggesting that they are dominated by dust evolution and settling. Finally, the presence of rare but remarkable disks with strong accretion at old ages reveals that some very massive disks may still survive to grain growth, gravitational instabilities, and planet formation.

  7. Extended Gamma-Ray Emission from the G25.0+0.0 Region: A Star-forming Region Powered by the Newly Found OB Association?

    Energy Technology Data Exchange (ETDEWEB)

    Katsuta, J. [Department of Physical Sciences, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Uchiyama, Y. [Rikkyo University, Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501 (Japan); Funk, S., E-mail: katsuta@hep01.hepl.hiroshima-u.ac.jp [Erlangen Centre for Astroparticle Physics, D-91058 Erlangen (Germany)

    2017-04-20

    We report a study of extended γ -ray emission with the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope , which is likely to be the second case of a γ -ray detection from a star-forming region (SFR) in our Galaxy. The LAT source is located in the G25 region, 1.°7 × 2.°1 around ( l , b ) = (25.°0, 0.°0). The γ -ray emission is found to be composed of two extended sources and one pointlike source. The extended sources have similar sizes of about 1.°4 × 0.°6. An ∼0.°4 diameter subregion of one has a photon index of Γ = 1.53 ± 0.15, and is spatially coincident with HESS J1837−069, likely a pulsar wind nebula. The other parts of the extended sources have a photon index of Γ = 2.1 ± 0.2 without significant spectral curvature. Given their spatial and spectral properties, they have no clear associations with sources at other wavelengths. Their γ -ray properties are similar to those of the Cygnus cocoon SFR, the only firmly established γ -ray detection of an SFR in the Galaxy. Indeed, we find bubble-like structures of atomic and molecular gas in G25, which may be created by a putative OB association/cluster. The γ -ray emitting regions appear confined in the bubble-like structure; similar properties are also found in the Cygnus cocoon. In addition, using observations with the XMM-Newton , we find a candidate young massive OB association/cluster G25.18+0.26 in the G25 region. We propose that the extended γ -ray emission in G25 is associated with an SFR driven by G25.18+0.26. Based on this scenario, we discuss possible acceleration processes in the SFR and compare them with the Cygnus cocoon.

  8. Investigación educativa reciente sobre México

    OpenAIRE

    Núñez-DelaPeña, Francisco J.; Mejía-Arauz, Rebeca

    1985-01-01

    Se presenta una muestra de la investigación educativa sobre México: 22 disertaciones doctorales aceptadas en universidades norteamericanas entre 1982 y 1984. Dos estudios conciernen a la teoría del capital humano; cinco tratan diversos aspectos relacionados con la administración educativa; uno es sobre la televisión; otro sobre las habilidades fonéticas de los niños; uno más es sobre profesionalización de los médicos; cuatro tocan aspectos de política educativa; tres tratan sobre los maestros...

  9. Sobre una Rodoficea parasita de Gelidiaceas

    OpenAIRE

    Seoane Camba, Juan Antonio

    1982-01-01

    En este trabajo se hace un estudio de una Rodofícea parásita, encontrada sobre Gelidium cantabricum Seoane-Camba y Gelidium sesquipedale (Clemente) Thuret. Por sus características generales atribuímos esta planta al género Gelidiocolax. descrito por Gardner en 1927 para un parásito de Gelidium pulchrum Gardner de las costas americanas del Pacífico...

  10. Reflexiones sobre el concepto de justicia

    Directory of Open Access Journals (Sweden)

    Víctor C. Pascual Planchuelo

    2005-06-01

    Full Text Available Este ensayo constituye una reflexión sobre el concepto de Justicia. No se centra, como tantos estudios al respecto, en el plano teórico y metafísico, sino que atiende problemas de mayor actualidad: la opinión de los ciudadanos, la postura de los profesionales y otros asuntos controvertidos del ámbito del Derecho.

  11. Trayectorias (sobre ruedas): un ensayo visual sobre los carritos de supermercado en la ciudad

    OpenAIRE

    Cruz, Edgar Gómez

    2014-01-01

    El siguiente trabajo es un breve bosquejo de las posibilidades del concepto de trabajo “trayectoria”. Una trayectoria no es sólo, en el sentido literal del término, el trazo del movimiento sobre un camino, sino que busca establecer una reflexión sobre las posibilidades de recolección de registros visuales/digitales/móviles para la investigación etnográfica desde la aleatoriedad del movimiento por la ciudad. El concepto de trayectoria busca dialogar con el de “flâneur” de De Certeau y Benjamin...

  12. A 80 OBS and 30 Land 3-component seismometers array encompassing the 280 km segment of the Lesser Antilles subduction megathrust seismogenic zone: view of current seismicity

    Science.gov (United States)

    Laigle, Mireille; Sapin, Martine; Ruiz, Mario; Diaz, Jordi; Kissling, Edi; Charvis, Philippe; Flueh, Ernst; Hirn, Alfred

    2010-05-01

    An extensive onshore and offshore seismic station array in the Lesser Antilles subduction zone allows to monitor microearthquake activity for a period of 4 months in a region previously outside of reach for detailed observation. Such a network has been possible thanks to a cluster of 3 seismic surveys (TRAIL - F/S Merian, SISMANTILLESII - N/O Atalante, and OBSANTILLES - N/O Antea) for deploying and recovering the instruments from several pools (Geoazur, INSU-IPGP, IFM-GEOMAR, AWI ). It has been followed by an additional deployment of the 28 GeoAzur OBSs (OBSANTILLES - N/O Antea) during 5 months in the south-western half. These operations have been carried out for the seismic investigation of the Antilles megathrust seismogenic zone in the framework of the THALES WAS RIGHT european project, and with also the financial support of the french ANR Catastrophes Telluriques et Tsunamis (SUBSISMANTI) and by the EU SALVADOR Programme of IFM-GEOMAR. Onshore, 30 3-components land stations (CSIC Barcelone, IPG Paris, INSU-RLBM and -LITHOSCOPE) have been temporarily deployed. The deep seismic structure of the whole area has been investigated during these seismic surveys by wide-angle reflection and refraction seismics recorded by these instruments as well as multi-channel reflection seismic imaging (MCS) along a dense grid of crossing profiles at the OBS positions providing excellent velocity information for the upper plate. Both the location and the interpretation of the recorded earthquake activity require constraints on the deep seismic structure, which will be discussed with respect to the 3D geometry of the interplate boundary and oceanic Moho, as well as those of the forearc basement and Moho. Preliminary locations have been obtained within a simple 1D velocity model by taking into account corrections for the variable thickness of the mud- and sediments layers beneath each OBS. The latter are estimated for both P- and S-waves to compensate for the huge structural

  13. II Jornadas sobre Emprendimiento Social y Colectivo

    OpenAIRE

    Centro de Investigación en Gestión de Empresas

    2013-01-01

    La línea temática principal del encuentro es el emprendimiento social y colectivo así como las diferentes líneas de investigación de los institutos y centros de la Red relacionadas, como: responsabilidad social, empleo y reincorporación al trabajo, inserción laboral, servicios sociales y dependencia, género, cambios legislativos, utilidad social, medio ambiente, desarrollo local,... Centro de Investigación en Gestión de Empresas (2013). II Jornadas sobre Emprendimiento Social y Colectivo. ...

  14. Literatura infantil sobre problemas infantiles: la diabetes

    OpenAIRE

    Lázaro Fernández, Patricia

    2015-01-01

    Debido al creciente número de casos de diabetes infantil que se está dando en la sociedad actual, no es raro encontrarse en las aulas cada vez más casos de esta enfermedad. Por esta razón, he decidido analizar dos libros sobre esta temática, para hacer un acercamiento del material seleccionado a las aulas y poder desarrollar junto con los niños un aprendizaje colectivo y cooperativo. En este trabajo se expone la importancia de la literatura y la literatura infantil como una ...

  15. Soportes apoyados sobre vigas pretensadas (EE. UU.

    Directory of Open Access Journals (Sweden)

    Editorial, Equipo

    1965-12-01

    Full Text Available This work has been awarded a prize by the Prestreesed Concrete Institute. It refers to a number of flyovers on the Arroyo Seco, of California. This river has been canalized, to help drainage in case of heavy rainfall. The canal runs through a highly populated zone, and a motor road and accessory ramps had to cross the canal. The resulting design involves three prestressed girders, lightly arched in a parabolic outline, resting on each river shore, running along the line of the bridge, over the canal. It was decided that the bridge piles should not rest on the river bed, in order not to reduce its flow capacity. The girders of a maximum length of 39 ms, are box shaped, and stiffened with thin diaphragms. The cylindrical pile, 1.50 m in diameter, is an integral part of the girder, and applies to it a concentrated load of about 4000 tons. The girders rest on reinforced concrete cubes, which in turn are supported by concrete slabs and piles driven into the soil.Esta obra ha sido premiada por el Prestressed Concrete Institute y se refiere a una serie de pasos superiores sobre el Arroyo Seco, en California, que se ha canalizado para servir de desagüe en el caso de avenidas torrenciales. El canal se halla en una zona de edificación densa y se trata del paso—sobre aquél—de una autopista y rampas de acceso. La solución adoptada consistió en tres vigas pretensadas, ligeramente arqueadas con perfil parabólico, apoyadas en las dos márgenes y situadas en correspondencia con los tres soportes, sobre el propio canal, ya que ninguno de aquéllos debía apoyarse en el lecho de este último al objeto de no disminuir su capacidad de desagüe. Las vigas—de unos 39 m de longitud la mayor—son del tipo cajón, rigidizadas con unos diafragmas de pequeño espesor. El soporte cilíndrico, de 1,50 m de diámetro, se solidariza con la viga y le transmite una notable carga concentrada, del orden de 4.000 toneladas. Los apoyos de estas vigas son simples dados

  16. Ensayo sobre la melancolía

    Directory of Open Access Journals (Sweden)

    Marta Chacón Salinas

    2013-07-01

    Full Text Available Este trabajo es un intento de delimitar la melancolía del conjunto de los trastornos depresivos y de reflexionar sobre sus características tal como aparecen en el discurso de los melancólicos. Se consideran algunas hipótesis en la línea psicoanalítica freudiana y lacaniana (Lambottc, Kristeva para entender cómo se va constituyendo en sus características principales: la intolerancia a la pérdida del objeto y el desfallecimiento del símbolo que le impide elaborar este duelo.

  17. Comentarios sobre dibujo analítico

    OpenAIRE

    Mata Botella, Elena

    2004-01-01

    Cuaderno de apoyo a la docencia del DIBUJO DE ARQUITECTURA que pretende hacer reflexionar al alumno (de primero o segundo de carrera) sobre un tipo de dibujo que aquí se ha llamado “dibujo analítico”. Un dibujo que a través de operaciones gráficas y conceptuales como la esquematización y la selección de información, tiende a alejarse de la descripción del objeto arquitectónico para adentrarse en determinados aspectos o dimensiones que subyacen en el proyecto arquitectónico. Unas notas intr...

  18. Sobre la evaluación docente

    OpenAIRE

    Chamizo, José Antonio

    2012-01-01

    Las universidades requieren una reflexión profunda sobre sus metas primordiales para construir una cultura de la evaluación de la actividad de enseñanza, la cual es diferente de la de investigación. La idea principal es que el proceso de evaluación sumativa, burocrático, superficial y cerrado, sea transformado en uno que involucre a los profesores y sea y abierto. Universities require a deep reflection on their ultimate goals to build a culture of evaluation on teaching activities, which a...

  19. Refuerzo de pavimentos sobre arcillas expansivas

    OpenAIRE

    Zornberg, Jorge

    2012-01-01

    El refuerzo de la capa base de pavimentos se ha utilizado a los efectos de: (i) aumentar la vida útil de un pavimento manteniendo el espesor de la capa base, o (ii) disminuir el espesor de la capa base manteniendo la vida útil del pavimento. Este artículo describe una tercera aplicación del refuerzo basal de pavimentos, a saber, la mitigación de grietas longitudinales inducidas en pavimentos construidos sobre subrasantes compuestas de arcillas expansivas. Aunque todavía existe la necesidad de...

  20. Cinco puntos sobre la revista Barcelona

    OpenAIRE

    Bertone Crippa, Mauro

    2012-01-01

    El humor, como género y narrativa mediática, ocupa un lugar destacado al interior del campo del periodismo gráfico argentino. Como emergente contemporáneo dentro de este ámbito, la revista Barcelona se vuelve un objeto de estudio sugestivo al trabajar, a partir del registro del humor, sobre la agenda y la enunciación de los medios gráficos de actualidad. De esta manera, se analizan las condiciones de producción del discurso de Barcelona para ver qué novedades aporta al campo del hu...

  1. Observaciones sobre colostomía

    Directory of Open Access Journals (Sweden)

    Jaime Escobar T.

    1971-01-01

    Full Text Available Se hace una revisión sobre 133 casos de colostomías hechas en pacientes del Hospital San Juan de Dios de Bogotá en un período de cinco años; el 43.7 por ciento de los casos eran heridas por arma de fuego. La mortalidad global fue de 16.5 por ciento. La colostomía derivativa, en ASA, ha bajado la mortalidad en las heridas de colon en dicho hospital.

  2. Multiphase formation of the Obří důl polymetallic skarn deposit, West Sudetes, Bohemian Massif: geochemistry and Re-Os dating of sulfide mineralization

    Science.gov (United States)

    Veselovský, František; Ackerman, Lukáš; Pašava, Jan; Žák, Karel; Haluzová, Eva; Creaser, Robert A.; Dobeš, Petr; Erban, Vojtěch; Tásler, Radko

    2018-06-01

    The Obří důl Fe-Cu-As polymetallic sulfide skarn deposit is developed in a metamorphic series in the West Sudetes, Bohemian Massif. It consists of lenses of marble, calc-silicate rocks, and skarns. We studied the Gustav orebody, which is located few hundred meters away from the contact with a large, late-orogenic Variscan Krkonoše-Jizera Plutonic Complex (KJPC) emplaced into shallow crust. Mineralogical and fluid inclusion study evidence indicates that the main sulfide stage, dominated by pyrrhotite, arsenopyrite, and chalcopyrite originated from aqueous hydrothermal fluids with salinity up to 8 wt% NaCl eq. with minimum homogenization temperatures ranging from 324 to 358 °C. These fluids mainly replaced carbonate-rich lithologies. Carbon, oxygen, and strontium isotope data in Ca-rich rocks imply total overprinting by channelized metasomatic fluid flow, which is most probably related to the intrusion of the KJPC, whereas δ34S values of sulfides argue for a magmatic source of sulfur. The Re-Os age of arsenopyrite overlaps published age data for the KJPC and suggests synchronous formation of the main sulfide mineralization and pluton emplacement.

  3. NEAR-INFRARED PERIODIC AND OTHER VARIABLE FIELD STARS IN THE FIELD OF THE CYGNUS OB7 STAR-FORMING REGION

    Energy Technology Data Exchange (ETDEWEB)

    Wolk, Scott J.; Rice, Thomas S. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Aspin, Colin A. [Institute for Astronomy, University of Hawaii at Manoa, 640 North Aohoku Place, Hilo, HI 96720 (United States)

    2013-04-15

    We present a subset of the results of a three-season, 124 night, near-infrared monitoring campaign of the dark clouds Lynds 1003 and Lynds 1004 in the Cygnus OB7 star-forming region. In this paper, we focus on the field star population. Using three seasons of UKIRT J, H, and K-band observations spanning 1.5 years, we obtained high-quality photometry on 9200 stars down to J = 17 mag, with photometric uncertainty better than 0.04 mag. After excluding known disk-bearing stars we identify 149 variables-1.6% of the sample. Of these, about 60 are strictly periodic, with periods predominantly <2 days. We conclude this group is dominated by eclipsing binaries. A few stars have long period signals of between 20 and 60 days. About 25 stars have weak modulated signals, but it was not clear if these were periodic. Some of the stars in this group may be diskless young stellar objects with relatively large variability due to cool starspots. The remaining {approx}60 stars showed variations which appear to be purely stochastic.

  4. Structural study of Na2O-B2O3-SiO2 glasses from molecular simulations using a polarizable force field.

    Science.gov (United States)

    Pacaud, Fabien; Delaye, Jean-Marc; Charpentier, Thibault; Cormier, Laurent; Salanne, Mathieu

    2017-10-28

    Sodium borosilicate glasses Na 2 O-B 2 O 3 -SiO 2 (NBS) are complex systems from a structural point of view. Three main building units are present: tetrahedral SiO 4 and BO 4 (B IV ) and triangular BO 3 (B III ). One of the salient features of these compounds is the change of the B III /B IV ratio with the alkali concentration, which is very difficult to capture in force fields-based molecular dynamics simulations. In this work, we develop a polarizable force field that is able to reproduce the boron coordination and more generally the structure of several NBS systems in the glass and in the melt. The parameters of the potential are fitted from density functional theory calculations only, in contrast with the existing empirical potentials for NBS systems. This ensures a strong improvement on the transferability of the parameters from one composition to another. Using this new force field, the structure of NBS systems is validated against neutron diffraction and nuclear magnetic resonance experiments. A special focus is given to the distribution of B III /B IV with respect to the composition and the temperature.

  5. Tributos sobre a folha ou sobre o faturamento? Efeitos quantitativos para o Brasil

    Directory of Open Access Journals (Sweden)

    Tiago V Cavalcanti

    2008-09-01

    Full Text Available Este artigo estuda os impactos alocativos e de bem-estar de uma reforma tributária que substitui os impostos sobre a folha de salários por outro que incide sobre a receita. Para isso, desenvolve-se um modelo neoclássico de crescimento econômico com impostos sobre a receita e sobre a folha de salários. As simulações com parâmetros da economia brasileira mostram que tal reforma tributária tem um efeito negativo no bem-estar, no estoque de capital de longo prazo e consequentemente no produto per capita de longo prazo. Contudo, o emprego aumenta.This paper studies the impacts of a tax reform which substitutes taxes on labor income by taxes on total revenue. In order to accomplish that, we construct and solve a general equilibrium neoclassical growth model with taxes on labor income and total revenue. The numerical simulations with Brazilian parameters show that such tax reforms would negatively affect welfare, the capital stock, and consequently per capita output. However, employment would increase. Such effects are quantitatively important.

  6. Sobre Geoestatística e mapas

    Directory of Open Access Journals (Sweden)

    Paulo Milton Barbosa Landim

    2015-06-01

    Full Text Available A Geologia, até há bem pouco tempo, era freqüentemente considerada uma ciência baseada em interpretações puramente qualitativas dos fenômenos geológicos. Nos últimos 40 anos, porém, tem sido notável a mudança da fase descritiva para a utilização de métodos quantitativos, principalmente na área da Geologia Aplicada. Entre tantos temas relacionados com a quantificação em Geologia o assunto abordado neste artigo, que pretende ser de cunho didático, diz respeito à aplicação da Geoestatística na confecção de mapas geológicos. Na primeira parte do trabalho é feita uma introdução sobre os aspectos quantitativos na interpretação dos fenômenos geológicos, em seguida conceitos básicos sobre a metodologia geoestatística e, na última parte, uma aplicação clássica da geoestatística linear, baseada nos conceitos de estacionaridade da covariância e do variograma, para a confecção de mapas.

  7. Estrategia educativa sobre sexualidad sana en adolescentes

    Directory of Open Access Journals (Sweden)

    Carmen Olivera Carmenates

    Full Text Available Se realizó un estudio de intervención con el objetivo de elaborar una estrategia educativa para incrementar conocimientos sobre sexualidad sana en un grupo de adolescentes de la escuela Secundaria Básica Alfredo Gómez del Municipio Camagüey entre octubre de 2012 y febrero de 2013. La muestra fue de 37 estudiantes. Se aplicó una encuesta que se convirtió en el registro primario de datos, confeccionada según criterios de expertos y la bibliografía. Una vez analizados los resultados se procedió a diseñar la estrategia educativa y posteriormente a su evaluación. Los datos se procesaron de forma automatizada. Antes de aplicar la estrategia educativa se comprobó que los adolescentes no tenían un adecuado conocimiento sobre la sexualidad sana. Los resultados demuestran la importancia de los estudios de intervención.

  8. The current content of artificial radionuclides in the water of the Tobol-Irtysh river system (from the mouth of the Iset River to the confluence with the Ob River)

    Energy Technology Data Exchange (ETDEWEB)

    Nikitin, Alexander I. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation)]. E-mail: nikitin@typhoon.obninsk.ru; Chumichev, Vladimir B. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Valetova, Nailia K. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Katrich, Ivan Yu. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Kabanov, Alexander I. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Dunaev, Gennady E. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Shkuro, Valentina N. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Rodin, Victor M. [Tobolsk Biological Station of RAS, 15, Voikov street, Tobolsk, Tyumen region 626150 (Russian Federation); Mironenko, Alexander N. [Tobolsk Biological Station of RAS, 15, Voikov street, Tobolsk, Tyumen region 626150 (Russian Federation); Kireeva, Elena V. [Tobolsk Biological Station of RAS, 15, Voikov street, Tobolsk, Tyumen region 626150 (Russian Federation)

    2007-07-15

    Data on content of {sup 90}Sr, {sup 137}Cs, {sup 239,240}Pu and {sup 3}H in water of the Tobol-Irtysh part of the Techa-Iset-Tobol-Irtysh-Ob river system (through which the 'Mayak' PA radioactive wastes are transported) are presented and discussed. The data were received in 2004-2005 under the ISTC project on radioecological monitoring of the Tobol and Irtysh rivers. Monthly observations of {sup 137}Cs, {sup 90}Sr and {sup 3}H content in water in the area of the Tobol and Irtysh confluence have been conducted starting from May 2004. To obtain information on the investigated river system as a whole, the radioecological survey of the Tobol and Irtysh rivers at the section from the mouth of the Iset River to the confluence with the Ob River was carried out in 2004. It is shown that the impact of 'Mayak' PA waste transport by {sup 90}Sr is distinctly traced as far as the area of the Irtysh and Ob confluence.

  9. The current content of artificial radionuclides in the water of the Tobol-Irtysh river system (from the mouth of the Iset River to the confluence with the Ob River)

    International Nuclear Information System (INIS)

    Nikitin, Alexander I.; Chumichev, Vladimir B.; Valetova, Nailia K.; Katrich, Ivan Yu.; Kabanov, Alexander I.; Dunaev, Gennady E.; Shkuro, Valentina N.; Rodin, Victor M.; Mironenko, Alexander N.; Kireeva, Elena V.

    2007-01-01

    Data on content of 90 Sr, 137 Cs, 239,240 Pu and 3 H in water of the Tobol-Irtysh part of the Techa-Iset-Tobol-Irtysh-Ob river system (through which the 'Mayak' PA radioactive wastes are transported) are presented and discussed. The data were received in 2004-2005 under the ISTC project on radioecological monitoring of the Tobol and Irtysh rivers. Monthly observations of 137 Cs, 90 Sr and 3 H content in water in the area of the Tobol and Irtysh confluence have been conducted starting from May 2004. To obtain information on the investigated river system as a whole, the radioecological survey of the Tobol and Irtysh rivers at the section from the mouth of the Iset River to the confluence with the Ob River was carried out in 2004. It is shown that the impact of 'Mayak' PA waste transport by 90 Sr is distinctly traced as far as the area of the Irtysh and Ob confluence

  10. Apuntes sobre el Cultivo del Cacao

    Directory of Open Access Journals (Sweden)

    Ochoa Horacio

    1940-03-01

    Full Text Available Por muchos años permaneció el cultivo del cacao en nuestro país, en un deplorable atraso técnico; el agricultor a duras penas si tenía conocimientos generales de su explotación y, de una industria que tuvo su auge debido a la extensividad de las plantaciones, hoy sólo resta una reducida porción de ella. ¿Qué factores operaron esa tan notoria reducción hasta el punto de que exportadores en otros tiempos nos convertimos en importadores obligados de ese producto? Hay muchas razones de orden técnico y de orden económico. Los cacaotaleros obtenían halagadoras retribuciones cuando el jornal consistía en la alimentación que se le daba a la peonada y cuando, generoso, añadía una sobretasa en dinero. Bajo ese sistema de explotación, el descuadre que pudiera ocasionar tanto las enfermedades criptogámicas como los plagas, no era suficiente como para provocar el pesimismo en el hacendado y por tanto inducirlo al abandono de la plantación. A medida que las condiciones sociales del campesino se fueron modificando y su standard de vida aumentaba, cambió fundamentalmente el mecanismo de la industria Se observó entonces que los árboles morían y que era pobre la producción; que lo que en tiempos pasados fuera un negocio lucrativo, se les había convertido en una actividad improductiva y, para controlar estos fenómenos que se generalizaban en todas las zonas cacaotaleras, opusieron la ignorancia, el rutinarismo y la desidia. Lentamente se han ido modificando los conceptos antiguos sobre el trabajo cultural y los cuidados que con relación a las enfermedades y plagas requiere este delicado cultivo; la rutina está echando paso atrás y las experiencias científicas que procuran la prosperidad del plantío, se ponen en práctica en algunas zonas . Esto da esperanza para la reconstitución de la industria cacaotalera en nuestro país, que cuenta con inmensas regiones de óptima calidad para hacerla florecer sobre bases nuevas, con

  11. Sobre a moralidade do direito em Kant

    Directory of Open Access Journals (Sweden)

    Joãosinho Beckenkamp

    2009-07-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2009v8n1p63 Na atual literatura sobre a fi losofi a prática de Kant há uma tendência a negligenciar a distinção feita na Metaphysik der Sitten entre direito (Jus e ética (Ethica, a ponto de ser a doutrina do direito de Kant vista como uma mera aplicação do imperativo categórico. Este artigo procura mostrar que Kant apresenta em sua doutrina do direito uma série de argumentos que logram estabelecer o direito de modo inteiramente independente da ética.

  12. Zubiri et alii sobre la consciencia

    Directory of Open Access Journals (Sweden)

    Solari, Enzo

    2016-08-01

    Full Text Available In recent literature on science and philosophy related to consciousness, the description and analysis are not always appropriate for the phenomenical consciousness that one wants to explain. From this one can sustain, contrary to some approaches to neuroscience and analytic philosophy, that the fact of consciousness previously requires a better phenomenological description and a more precise conceptual analysis.En la reciente literatura científica y filosófica sobre la consciencia no siempre se describe ni analiza adecuadamente cuál es esa consciencia fenoménica que se desea explicar. De ahí que se argumente, contra ciertas aproximaciones de la neurociencia y la filosofía analítica, que el hecho de la consciencia necesita previamente de una mejor descripción fenomenológica y de una más ajustada analítica conceptual.

  13. Notas de historia sobre ética

    OpenAIRE

    Hernando Forero Caballero

    1998-01-01

    La primera reglamentación de que se tiene noticia sobre la profesión médica es la dictada por el rey Hamurabi de Babilonia, en la cual se protocolizó el códice que lleva su nombre, hacia los 2000 años antes de Cristo. En el Egipto antigua, los libros Herméticos del Dios Thoh contenían profundos preceptos de moral médica y conceptos científicos importantes de la medicina de entonces. En Persia y Arabia, los libros  Zendavesta y Vendia contenían principios de deontología médica, lo mismo que en...

  14. Reflexiones sobre contabilidad privada y contabilidad nacional

    Directory of Open Access Journals (Sweden)

    José Arturo Gutiérrez

    1995-01-01

    Full Text Available Se discuten las interrelaciones de la contabilidad privada y la contabilidad nacional, insistiendo en sus condicionantes internos contradictorios en relación con la sobredeterminación de la formación económico-social vigente. En relación con ello se introduce la reflexión sobre la unidad contradictoria entre empresa y capital, esto es, la base técnica frente a su determinante socioeconómico, conflicto que la propia contabilidad privada expresa: al describir el capital aporta necesariamente el conocimiento de la producción social. De allí su probable compatibilidad con el propósito de la contabilidad nacional, y, por extensión, ambiental.

  15. IMPRESSÕES SOBRE A JORNADA

    Directory of Open Access Journals (Sweden)

    Gabrie Rodrigues da Silva

    2012-07-01

    Full Text Available Entre os dias 10 e 13 de Outubro de 2008 ocorreu na Universidade Federal de Goiás – UFG campus de Catalão a IX Jornada sobre o Trabalho. Evento realizado anualmente pelo CEGeT (Centro de Estudos de Geografia do Trabalho, da UNESP/FCT campus de P. Prudente. No entanto, no ano de 2006 foi realizado na UNIOESTE campus de Marechal Cândido  Rondon/PR, através da iniciativa do Geolutas (Grupo de Estudos das Lutas no Campo e na Cidade que se prontificou a iniciar uma nova fase do evento, a de migração para outras Universidades, onde existem as células do CEGeT.

  16. Sobre el Boletín

    Directory of Open Access Journals (Sweden)

    Andrés Arias

    2007-04-01

    Full Text Available En la página de Internet de la Biblioteca Luis Ángel Arango se indica que una de la funciones principales del Boletín es la de reseñar la novedades bibliográfica que van apareciendo en el país. "Novedades": de lo nuevo, tanto en las publicaciones como en las reseñas. Es decir, si lo que asegura la página de la Biblioteca es cierto, quien se acerca al Boletín debe encontrarse con comentarios recientes sobre libros recientes. Con guía que le ayuden a elegir entre las mil ofertas que hay en el mercado bibliográfico. Pero bien sabemos que este objetivo no se cumple.

  17. Notas de historia sobre ética

    Directory of Open Access Journals (Sweden)

    Hernando Forero Caballero

    1998-01-01

    Full Text Available La primera reglamentación de que se tiene noticia sobre la profesión médica es la dictada por el rey Hamurabi de Babilonia, en la cual se protocolizó el códice que lleva su nombre, hacia los 2000 años antes de Cristo. En el Egipto antigua, los libros Herméticos del Dios Thoh contenían profundos preceptos de moral médica y conceptos científicos importantes de la medicina de entonces. En Persia y Arabia, los libros  Zendavesta y Vendia contenían principios de deontología médica, lo mismo que en el Código de Manu de las Indias y en los libros de la época de Confucio en la China.

  18. A DYNAMICAL STUDY OF SUSPECTED RUNAWAY STARS AS TRACES OF PAST SUPERNOVA EXPLOSIONS IN THE REGION OF THE SCORPIUS-CENTAURUS OB ASSOCIATION

    International Nuclear Information System (INIS)

    Jilinski, E.; Ortega, V. G.; Drake, N. A.; De la Reza, R.

    2010-01-01

    We address the question of identifying possible past supernovae events taking place in the region of the Scorpius-Centaurus (Sco-Cen) OB association based on stars proposed by Hoogerwerf et al. With this purpose, we obtained a time series of high-resolution spectra of six stars (HIP 42038, HIP 46950, HIP 48943, HIP 69491, HIP 76013, and HIP 82868) which, according to Hoogerwerf et al., may have been runaway stars with origins in the region of the Sco-Cen association. This also includes the nearby young open clusters IC 2391 and IC 2602. If confirmed, such supernovae events could, in principle, have played a role in triggering the formation of some small stellar groups thought to be associated with the Sco-Cen association. Our analysis shows that, except for HIP 48943, the remaining stars are spectroscopic binary systems. For HIP 46950 and HIP 69491, this was already noted by other authors. Our high-resolution spectra allowed us to obtain the radial velocities for all the stars which, combined with their proper motions and parallaxes from Hipparcos, provide a means to investigate, by retracing their orbits, if the Sco-Cen region was, in fact, the origin of these stars. We find that none of these systems originated in the Sco-Cen region. Exploring the possibility that the birthplace of the studied stars occurred in the clusters IC 2391 and IC 2602, we noticed that at the epoch of 2-3 Myr ago these clusters were at a distance comparable with their tidal radii.

  19. Up-to-date concentrations of long-lived artificial radionuclides in the Tom and Ob rivers in the area influenced by discharges from Siberian chemical combine

    International Nuclear Information System (INIS)

    Nikitin, A.I.; Kryshev, I.I.; Bashkirov, N.I.; Valetova, N.K.; Dunaev, G.E.; Kabanov, A.I.; Katrich, I.Yu; Krutovsky, A.O.; Nikitin, V.A.; Petrenko, G.I.; Polukhina, A.M.; Selivanova, G.V.; Shkuro, V.N.

    2012-01-01

    The Siberian Chemical Combine (SCC) is located in Seversk (formerly known as Tomsk-7) in the Tomsk Region of the Russian Federation. The main contribution of radionuclides in the SCC process water discharged into the Tom River was from the single-pass reactors, now removed from service (the last SCC reactor was shutdown on June 5, 2008). The data on the concentrations of 90 Sr, 137 Cs, 239,240 Pu and other artificial radionuclides in water, bottom sediments and flood-plain soils of the Tom and Ob rivers from Tomsk to the confluence of the rivers, are presented and discussed. The results of measurements carried out after shutdown of the last SCC single-pass reactor indicated no radiologically significant consequences of SCC activities for the studied water environment compartments. Contemporary activity concentrations of long-lived artificial radionuclides 3 H, 90 Sr, 137 Cs and 239,240 Pu in river water were below the intervention levels established by current regulations of the Russian Federation for these radionuclides. The results of 3 H analysis in water from the Tom and Samuska rivers demonstrated no inflow of contaminated formation water to surface water from the sites where liquid radioactive wastes of the SCC were injected below the surface. However, the density of flood-plain soil contamination by long-lived 137 Cs in the area influenced by SCC liquid discharges was higher than regional technogenic background. There were local flood-plain areas contaminated not only by 137 Cs, but also other gamma-emitters, such as 60 Co and 152 Eu.

  20. Characterization of a thermostable recombinant l-rhamnose isomerase from Caldicellulosiruptor obsidiansis OB47 and its application for the production of l-fructose and l-rhamnulose.

    Science.gov (United States)

    Chen, Ziwei; Xu, Wei; Zhang, Wenli; Zhang, Tao; Jiang, Bo; Mu, Wanmeng

    2018-04-01

    l-Hexoses are rare sugars that are important components and precursors in the synthesis of biological compounds and pharmaceutical drugs. l-Rhamnose isomerase (L-RI, EC 5.3.1.14) is an aldose-ketose isomerase that plays a significant role in the production of l-sugars. In this study, a thermostable, l-sugar-producing L-RI from the hyperthermophile Caldicellulosiruptor obsidiansis OB47 was characterized. The recombinant L-RI displayed maximal activity at pH 8.0 and 85 °C and was significantly activated by Co 2+ . It exhibited a relatively high thermostability, with measured half-lives of 24.75, 11.55, 4.15 and 3.30 h in the presence of Co 2+ at 70, 75, 80 and 85 °C, respectively. Specific activities of 277.6, 57.9, 13.7 and 9.6 U mg -1 were measured when l-rhamnose, l-mannose, d-allose and l-fructose were used as substrates, respectively. l-Rhamnulose was produced with conversion ratios of 44.0% and 38.6% from 25 and 50 g L -1 l-rhamnose, respectively. l-Fructose was also efficiently produced by the L-RI, with conversion ratios of 67.0% and 58.4% from 25 and 50 g L -1 l-mannose, respectively. The recombinant L-RI could effectively catalyze the formation of l-rhamnulose and l-fructose, suggesting that it was a promising candidate for industrial production of l-rhamnulose and l-fructose. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  1. Effects of coronal regions on the x-ray flux and ionization conditions in the winds of ob supergiants and of stars

    International Nuclear Information System (INIS)

    Cassinelli, J.P.; Olson, G.L.

    1979-01-01

    The anomalously strong O VI and N V lines in O stars and the C IV lines in B supergiants may be due to Auger ionization by X-rays from a thin coronal zone at the base of the cool stellar winds. We determine the size of a corona that is necessary to produce the overall ionization conditions in zeta Pup as has been deduced by Olson from line profile analysis. In the ionization balance calculations we account for diffuse radiation field in the wind and for the large optical depths in the He II continuum due to radiative and Auger ionization edges of abundant elements. The X-ray flux transmitted through the wind is calculated and compared with upper limits derived for upper limits derived for zeta Pup observations from ANS and Uhuru satellites. It is found that a coronal zone with a temperature of 5x10 6 K and a volume emission measure of 10 58 cm -3 can produce the required ionization in a wind having a temperature of 30,000--35,000 K. The emergent X-ray flux bears little resemblance to the coronal emissivity because of the opacity of the wind. The X-ray flux nearly reaches the upper limits derived from the ANS observations and, at several energy bands, should be detectable by the HEAO B satellite. A simplified analysis of the Auger ionization process is developed and applied to other Of and OB supergiants. We find that the model can explain the presence of C IV and Si IV in supergaints with effective temperatures as low as 12,000 K and can explain the appearance of O VI and N V lines in early type supergiants as late as BO.5 and B2, respectively

  2. Kharlamova, N. F. Climate Changes over the 20th and 21st Centuries in the Upper Basin of the Ob and Irtysh Rivers (Altai Region)

    Science.gov (United States)

    Fedorovna, K. N., II

    2015-12-01

    The Russian climate is more sensitive to global warming than the climate in many other parts of the world. According to the Second Climate Change National Assessment, since the mid-1970s, the average temperature has been rising with rate of 0.43 ° C / 10 years, which is more than two times higher than the rate of global warming. In the Altai region, the rate of temperature change is higher than the average for Russia with an annual surface air temperature increase equal to 1.8°C the 20th century. The maximum value of this increase the past 50 years (1963-2013) was found in the intermountain basins of Altai (+ 2.6°C) mainly due to the winter and spring warming with changes in the summer season being considerably smaller. This warming is accompanied with negative tendencies in annual precipitation over the entire Altai Krai. The mountain ranges of Altai are called the "water tower" of Northern Eurasia. The northward flow of numerous rivers streaming down from these ranges in the Basin of the Ob and the Irtysh Rivers is formed by melting of Altai glaciers and snowfields. Since the middle of the 19th century the largest glaciers in the Altai have retreated by 1.5-2 km and the thickness of their tails decreased by 50-70 m. The reduction of mountain glaciers poses a threat of depletion of water flow to major agricultural regions downstream affecting human activity and even the drinking water availability. Permafrost in the Altai Mountains is actively degraded (thawing), which represents a danger for infrastructure (first of all for roads and pipelines) and increases risk of catastrophic events (landslides, mudflows). Continued warming could contribute to a significant reduction of water resources, biodiversity and other negative processes in the region.The reported study was partially supported by the Russian Foundation for Baseline Research (project No. 15-45-04450).

  3. Notas sobre Matisia longiflora Gleas. (Bombacaceae Notas sobre Matisia longiflora Gleas. (Bombacaceae

    Directory of Open Access Journals (Sweden)

    Fernández Alonso José Luis

    1992-09-01

    Full Text Available Dentro del grupo de géneros de bombacáceas de hojas simples que componen la tribu Quararibeae (= Matisieae Hutchinson, es Matisia Humb. & Bonpl. el que cuenta con mayor número de especies en Colombia. Al respecto se presentaron recientemente algunas consideraciones preliminares sobre la diversidad de especies en este grupo en Colombia (Fernández Alonso, 1991.

  4. Miradas francesas sobre la Guerra Civil

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    Jean-Marc DELAUNAY

    2015-03-01

    Full Text Available Como muestra el asunto hoy vigente —pero relativamente discreto— de la venta del edificio que abrigó el antiguo taller parisino donde Picasso hizo su Guernica (1937, la Guerra Civil española sigue siendo en Francia una referencia mayor de la historia contempóranea. Al ritmo de las conmemoraciones decenales de su estallido (1996/2006, se ha desarrollado una verdadera marea memorial nutrida tanto por la apertura de archivos escritos y audiovisuales como por la desinhibición de los nietos de exiliados condicionados durante tanto tiempo por la historia de la derrota de sus padres y abuelos. Animan el debate las tribulaciones de la vida política española actual, entre neofranquismo, republicanismo y nacionalismos centralistas y/o regionales. Por haber sido la unica vía de salida, Francia —metropolis y África del norte— se vio más involucrada que cualquier otro país al recibir la aplastante mayoría de los exiliados. Aunque los verdaderos especialistas en dicha guerra son poco numerosos, todo un mundillo se ha otorgado el derecho y la capacidad de escribir sobre ella como descendientes de exiliados o activistas políticos, sobre todo en el sur de Francia. Todos los medios se ven afectados: desde la literatura estrictamente histórica al internet. De las obras eruditas, de vulgarización —también para la juventud— a las memorias arrancadas al olvido; de las actas de los coloquios a los tebeos; de los álbumes fotográficos a los documentales (siempre pro republicanos. Al tiempo toda la producción histórica generalista o militar junta a los partidarios de una visión anticomunista, neutralista o manifestamente pro franquista. La Guerra Civil española, que había encontrado una Francia dividida, la reencuentra de nuevo como tal a pesar de todos los intentos de mediación científica.

  5. Reflexiones sobre la crisis. Vidas y Memorias

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    Estela Vázquez

    2009-11-01

    Full Text Available El artículo se plantea analizar la deslegitimación de la política y de los políticos, así como del acto de votar. Encuadrado en el marco del contexto de la crisis argentina de los últimos años, quiere responder, por medio de la entrevista oral y la historia de vida, a cómo se ve desde la ciudadanía el ejercicio de la democracia, las prácticas políticas, la alternancia en el poder y de qué forma todo esto influye en las vidas personales de los entrevistados. Asimismo, se entrelaza el análisis del espectáculo político con el público que ofrecen los medios de comunicación y de entretenimiento, con lo que se viene a concluir que es cada vez más difícil distinguir en el debate social la ficción de los hechos y personajes verdaderamente reales. Para este trabajo se analizan tres trayectorias laborales de ex-empleados de la administración pública, y sus apreciaciones sobre el despido, vinculando estas experiencias de vida a la formación de sus ideas sobre la política y los políticos.. Sus lugares de trabajo eran el Registro Civil, la Secretaría de Educación y la Legislatura, respectivamente.__________________ABSTRACT:This article tries to analyse the discredit of politics and politicians along with the act of voting. Placed in the context of the Argentine crisis, it wants to determinate through oral interview and life story how citizens see the exercise of democracy, the political practices and the power switching, to establish how they have influenced in the lifes of the persons being interviewed. At the same time, it interlaces an analysis of he political spectacle shown to the public by the media, to conclude that is becoming more a more difficult to distinguish the fiction from the real characters in the social debate.

  6. El puente Bendorf sobre el Rin (Alemania

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    Hirschfeld, Kurt

    1966-03-01

    Full Text Available This recently completed bridge over the Rhine is 524 m long, and is a reinforced concrete structure, built by successive overhangs, without the aid of formwork or scaffolding. The centre span is 208 m in length, and the other six vary between 43 and 71 m. The deck consists of two independent parts, including a continuous box girder, with a hinge at the crown of the main span. It is stiffened with transversal diaphragms, spaced every 34 m. The piles rest on pneumatic caissons, which go down to 16 m below the river bed. The attachment between the piles and the caissons is rigid, at the central pile, and at the other piles it operates through a roller bearing. The central span was constructed without intermediate supports for the first 40 m, and beyond that stage, for greater safety, a provisional movable tower was built, as a temporary point of support for the free overhang. The various sections were concreted and post-tensioned with 32 mm bars, by the Dywidag procedure. Account was taken of the varying deformations that took place at each section, so as to add the necessary counter-deflection that finally enabled the two sides of the arch to meet at the crown at the calculated point.Este puente, recientemente construido, sobre el Rin, tiene una longitud total de 524 m, es de hormigón armado y se ha realizado por el procedimiento de voladizos sucesivos, sin entramado auxiliar ni cimbras. La luz del tramo central es de 208 m, y las de los otros seis oscilan entre 43 y 71 m. La estructura del tablero se compone de dos partes independientes, formadas por una viga tipo cajón, continua, con una articulación en la clave del tramo central y rigidizada con diafragmas transversales espaciados a 34 m. Las pilas centrales se apoyan sobre cajones neumáticos que descienden 16 m debajo del fondo del río. La unión entre estas pilas y la estructura cajón es rígida, y de tipo rodillo en las otras pilas. El tramo central se ha construido por voladizos

  7. REPRESENTAÇÃO SOCIAL DOS ENFERMEIROS SOBRE CUIDADOS PALIATIVOS

    OpenAIRE

    Coelho de Britto, Sabrina Maria; de Souza Ramos, Raquel; dos Santos, Érick Igor; da Silva Veloso, Olga; Melo da Silva, Aline; de Aguiar Mariz, Rosângela Guiomar

    2015-01-01

    Introdução: O presente estudo refere-se a um processo de investigação sobre a representação social dos enfermeiros sobre cuidados paliativos. Objetivos: identificar a estrutura das representações sociais dos enfermeiros sobre cuidados paliativos; discutir as repercussões dessas representações no cotidiano da prática assistencial. Materiais e Métodos: Para a realização deste estudo foram abordados 70 enfermeiros que atuam nas enfermarias do serviço de Clínica Médica. A técnica para coleta de d...

  8. Pistas para pensar las significaciones imaginarias sobre la invariancia

    OpenAIRE

    Bilyk, Pablo Andrés

    2011-01-01

    Este escrito propone un primer esbozo de nominalizaciones sobre las significaciones imaginarias en torno a la idea de invariancia, con el fin de comenzar a mapear categorías para transitar que nos permitan pensar las construcciones fantasmáticas sobre el no-cambio. En definitiva, se trata de avanzar sobre la problematización de los modos de funcionamiento, constitución y reconfiguraciones de las hegemonías en los entramados sociales contemporáneos. Facultad de Periodismo y Comunicación Soc...

  9. El abrigo de Martinarri (Obécuri, Treviño: una ocupación del Tardiglaciar en la Cuenca Alta del Ebro

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    Alday, Alfonso

    2012-12-01

    Full Text Available We present recently discovered Martinarri’s site, in Treviño. The initial excavations have shown that it was occupied during the transition from Pleistocene to Holocene, providing information of a largely unknown episode in the Upper Ebro and in the interior of the Iberian peninsula. The text provides an initial assessment of the stratigraphic sequence and the materials recovered. Along with carbon-14 data (unpublished, we propose an initial interpretation of the dynamics of occupation of the site. Also, the nature of the period to which it refers, requires a review of currently available knowledge and reflection on its characterization.

    Presentamos el yacimiento de Martinarri, recientemente descubierto en Treviño. Los iniciales trabajos de excavación han evidenciado ocupaciones en el tránsito del Pleistoceno al Holoceno que llenan de contenido un episodio cultural muy desconocido en el Alto Ebro, en particular, y en el interior de la Península Ibérica, en general. En el texto se ofrece una primera evaluación tanto de la secuencia estratigráfica como de los materiales recuperados, esbozando junto con los datos radiocronológicos (inéditos, una primera interpretación de la dinámica ocupacional del lugar. Dada la propia naturaleza del período se revisa el conocimiento disponible en la actualidad sobre el mismo y se reflexiona sobre su caracterización.

  10. Promise(s of mesenchymal stem cells as an in vitro model system to depict pre-diabetic/diabetic milieu in WNIN/GR-Ob mutant rats.

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    Soundarya L Madhira

    Full Text Available BACKGROUND: Development of model systems have helped to a large extent, in bridging gap to understand the mechanism(s of disease including diabetes. Interestingly, WNIN/GR-Ob rats (Mutants, established at National Centre for Laboratory Animals (NCLAS of National Institute of Nutrition (NIN, form a suitable model system to study obesity with Type 2 diabetes (T2D demonstrating several secondary complications (cataract, cardiovascular complications, infertility, nephropathy etc. The present study has been carried out to explore the potent application(s of multipotent stem cells such as bone marrow mesenchymal stem cells (BM-MSCs, to portray features of pre-diabetic/T2D vis-à-vis featuring obesity, with impaired glucose tolerance (IGT, hyperinsulinemia (HI and insulin resistance (IR seen with Mutant rats akin to human situation. METHODOLOGY/PRINCIPAL FINDINGS: Primary cultures of BM-MSCs (third passage from Mutants, its lean littermate (Lean and parental control (Control were characterized for: proliferation markers, disease memory to mark obesity/T2D/HI/IR which included phased gene expression studies for adipogenic/pancreatic lineages, inflammatory markers and differentiation ability to form mature adipocytes/Insulin-like cellular aggregates (ILCAs. The data showed that BM-MSCs from Mutant demonstrated a state of disease memory, depicted by an upregulated expression of inflammatory markers (IL-6, TNFα; increased stem cell recruitment (Oct-4, Sox-2 and proliferation rates (CD90+/CD29+, PDA, 'S' phase of cell cycle by FACS and BrdU incorporation; accelerated preadipocyte induction (Dact-1, PPARγ2 with a quantitative increase in mature adipocyte formation (Leptin; ILCAs, which were non-responsive to high glucose did confer the Obese/T2D memory in Mutants. Further, these observations were in compliance with the anthropometric data. CONCLUSIONS: Given the ease of accessibility and availability of MSCs, the present study form the basis to report for

  11. Estudio sobre encofrados de madera modernos

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    de la Peña Aznar, Juan M.

    1980-11-01

    Full Text Available The author continues the development of the subject «Modern Timber Formwork», by summing up the comparative examination —already carried out in Part III of this Study— of the different types of glued timber existing on the market. In addition, the loads and stresses allowable for coniferous timber and the proposal for establishing Regulations for the Timber Section of the Research and Experimental Forestry Institute of Spain are given. In part V of the author's Study, published in this article, the important subject of the glues used for joining timber, a truly vital point in order to obtain louvered timber beams which are simply glued together, is approached.

    El autor continúa el desarrollo del tema sobre «Encofrados de madera modernos», resumiendo el estudio comparativo —ya hecho en la Parte III de este Estudio— de las diferentes vigas de madera encolada existentes en el mercado dando, además, las cargas y tensiones admisibles para maderas coníferas y la propuesta de Reglamentación de la Sección de Maderas del Instituto Forestal de Investigaciones y Experiencias de España. En la parte V del Estudio del autor, publicada en este articulo, se aborda el importante tema de las colas empleadas para las uniones de madera, algo realmente vital para la obtención de vigas de madera en celosía simplemente encoladas.

  12. Sobre a diversidade de sentidos de comunidade

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    Silva, Rosalina Carvalho da

    2005-01-01

    Full Text Available Nosso objetivo neste trabalho foi realizar algumas reflexões sobre as implicações da expansão do uso do termo comunidade e sua diversidade de sentidos. Pretendemos discutir os usos indiscriminados do termo nem sempre acompanhados da devida reflexão e crítica. A partir das perspectivas da sociologia, saúde e psicologia social identificamos que o termo ainda permanece arraigado aos ideais de comunidades naturais próprios aos períodos do feudalismo e do pós-revolução industrial. Esta concepção pode camuflar formas impositivas de trabalho em muitos dos quais o termo comunidade é empregado praticamente como sinônimo de população-alvo e participação comunitária é vista meramente como freqüência às atividades propostas por profissionais que determinam quem são as comunidades. Comprometem-se assim, as práticas emancipatórias. Para repensarmos comunidades, hoje, consideramos necessário relevar os aspectos processuais relacionais, dialógicos e identitários em constantes mudanças. Assim, a condição de comunidade extrapola a delimitação geográfica para as possibilidades de pertencimento e participação através dos espaços simbolicamente delimitados

  13. NOTAS SOBRE A IRRACIONALIDADE DA GUERRA

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    Edilene Leal

    2014-08-01

    Full Text Available Nesse artigo, procedemos a uma análise sobre a irracionalidade da guerra em tempos cada vez mais caracterizados pela evolução da racionalidade técnica, ou seja, em tempos contemporâneos. Esse é o ponto a partir do qual traçamos, aqui, um percurso argumentativo dividido em duas partes. Na primeira, reconstituímos elementos da concepção de guerra de filósofos como Maquiavel, Clausewitz e Kant, destacando, nos dois primeiros pensadores, a prerrogativa de que a guerra é racional quando se configura meio para fins políticos. Na segunda parte, confrontamos essa racionalidade política da guerra com a dupla dimensão técnica que a guerra assumiu: de um lado, a guerra como um fim em si mesmo e não mais como meio da ação política; de outro, a dimensão racionalizante da guerra como resultado do progresso técnico e científico, atualizada como guerra do terror.

  14. Estudio sobre encofrados de madera modernos

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    de la Peña Aznar, Juan M.

    1980-03-01

    Full Text Available This article is a compendium of almost all of the existing literature, in addition to important contributions by the author, on forms —an important aspect of the building industry, as their cost is not infrequently as high or higher than that of the actual concrete poured. Thus, to the benefit of architects, engineers, site supervisors and carpenters, data are provided, as well as charts and calculations for a rational use of these forms, whether wooden, metal or of other material.

    En esta artículo sa compendia casi toda la literatura existente, así como importantes aportaciones del autor, sobre encofrados, capítulo importante en la construcción, ya que su costo resulta no pocas veces tan elevado o más que el propio hormigón vertido. Así, pues, en beneficio de arquKectos, ingenieros, encargados y carpinteros, se dan datos, cuadros y abacos para el empleo racional de los citados encofrados, sean de madera, metálicos, etcétera.

  15. Estudio sobre encofrados de madera modernos

    Directory of Open Access Journals (Sweden)

    de la Peña Aznar, Juan M.

    1980-06-01

    Full Text Available This article is a compendium of almost all of the existing literature, in addition to important contributions by the author, on forms —an important aspect of the building industry, as their cost is not infrequently as high or higher than that of the actual concrete poured. Thus, to the benefit of architects, engineers, site supervisors and carpenters, data are provided, as well as charts and calculations for a rational use of these forms, whether wooden, metal or of other material.

    En este artículo se compendia casi toda la literatura existente, así como importantes aportaciones del autor, sobre encofrados, capítulo importante en la construcción, ya que su costo resulta no pocas veces tan elevado o más que el propio hormigón vertido. Así pues en beneficio de arquitectos, ingenieros, encargados y carpinteros se dan datos, cuadros y ábacos para el empleo racional de los citados encofrados, sean de madera, metálicos, etc.

  16. Estudio sobre encofrados de madera modernos

    Directory of Open Access Journals (Sweden)

    de la Peña Aznar, Juan M.

    1980-10-01

    Full Text Available This article is a compendium of almost all of the existing literature, in addition to important contributions by the author, on forms —an important aspect of the building industry, as their cost is not infrequently as high or higher than that of the actual concrete poured. Thus, to the benefit of architects, engineers, site supervisors and carpenters, data are provided, as well as charts and calculations for a rational use of these forms, whether wooden, metal or of other material.

    En este artículo se compendia casi toda la literatura existente, así como importantes aportaciones del autor, sobre encofrados, capítulo importante en la construcción, ya que su costo resulta no pocas veces tan elevado o más que el propio hormigón vertido. Así pues en beneficio de arquitectos, ingenieros, encargados y carpinteros se dan datos, cuadros y ábacos para el empleo racional de los citados encofrados, sean de madera, metálicos, etc.

  17. Considerações sobre Agamben

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    Luiz Hebeche

    2012-12-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2012v11n3p329 Giorgio Agamben em pequenos artigos, entrevistas e baixo-assinados tem chamado a atenção para o estado de abandono do povo palestino, mas curiosamente esse assunto não é tratado em suas obras mais importantes. Em Homo sacer, por exemplo, ele retoma o termo “muçulmano”, comumente empregado pelos prisioneiros dos campos de concentração como a expressão do maior abandono possível da existência humana, mas não reflete suficientemente sobre a origem dessa palavra, isto é, de que nessa expressão já se encontrava o ódio e o desprezo do sionismo, não só entre os próprios prisioneiros, mas pelo povo palestino e pelos árabes em geral. A seguir comentaremos brevemente algumas obras desse autor que, dando continuidade à ideologia da vitimação, faz com que, mais uma vez, o passado inominável acabe encobrindo o presente abominável.

  18. Apuntes sobre el Cultivo del Cacao

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    Chavarriaga. Eduardo

    1940-09-01

    Full Text Available El sombrío constituye uno de los problemas que se presentan en el cultivo del cacao, de necesaria resolución para ayuda del agricultor en su labor al producir tan importante grano. Contribuye a la economía del cultivo un conocimiento amplio de la cuestión que debe preocupar al productor inquiriendo no solamente por lo acostumbrado en la región, sino por lo que en otras partes se conoce sobre el particular, para abandonar un poco el emperismo y hacer una industria cada día más próspera. Como razón a favor del sombrío, tenemos los países en donde se produce cacao de fina calidad; Trinidad, Venezuela. Nicaragua, siempre acostumbran la sombra; y sin ir muy lejos, en el Valle del Cauca, donde no se cultiva a pleno sol y se obtienen plantaciones de larga duración y producto superior, es bien conocido el beneficio de ella; allí, los agricultores conocen los desastrosos efectos que ocasiona la falta de sombra, cuando por cualquier causa mueren los árboles que la suministran. Por tanto, en este estudio indicaremos el uso de la sombra para el cacao, como el medio de conservar la fertilidad y buenas condiciones del suelo, obtener buenos rendimientos y asegurar larga vida a la plantación.

  19. Análisis sobre la factibilidad de implementar un producto de derivados sobre gas natural en Colombia

    OpenAIRE

    Dowd Aguirre, Jessica Alexandra; Tirado Naranjo, Lina María

    2012-01-01

    El objetivo de este trabajo es realizar un análisis sobre la factibilidad de implementar un producto de derivados sobre gas natural en Colombia dado el desarrollo del sector y la importancia de este hidrocarburo como fuente alternativa de generación eléctrica. 73 p. Contenido parcial: Situación actual del mercado de gas natural colombiano -- Expectativas del mercado de gas natural colombiano -- Mercados de derivados sobre gas natural en Europa y Estados Unidos -- Mercado de gas natural ...

  20. Doppiaggio in italiano del film 'Astérix et Obélix - Au service de Sa Majesté'. Trasposizione degli elementi culturali e umoristici

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    Alessandra Rollo

    2016-01-01

    Full Text Available Abstract – At present, audiovisual translation is one of the most interesting and stimulating domains within the field of Translation Studies. Resting on a rich semiotic apparatus, marked by the interplay of a double channel of communication – audio/visual – with different types of signs – verbal/non-verbal codes, the audiovisual text is a complex one, whose transfer from one language into another represents a challenging task for every professional in this field. Especially in dubbing, the translator/adapter has to work on the interlinguistic level as well as on the intersemiotic level (iconic, paralinguistic elements, etc.: as many codes having great semantic potential and transmitting useful cultural information, as we shall see in the film which we have taken as the object of our analyses: Astérix et Obélix: Au Service de Sa Majesté (2012. This fourth film adaptation (except cartoons of Astérix’s adventures offers a series of gags playing on the parody of typical traditions, symbols, linguistic clichés and cultural stereotypes associated with British culture. Italian dubbing resorts to different translation strategies, some of which come under a foreignizing approach, aiming at preserving the original’s colour and mood, whereas others are in line with a domesticating approach, in order to bring the product closer to the final audience. Indeed, instead of stressing the idea of a polarization or a dichotomy between two contrasting perspectives, we find it advisable to envisage a gradation between two instances which occur at the same time and coexist in a complementary way during the translation process.   Keywords: audiovisual translation; dubbing; cultural elements; humorous elements; foreignization/domestication.     Résumé – La traduction audiovisuelle se configure à l’heure actuelle comme l’un des domaines les plus intéressants et les plus stimulants dans le panorama des etudes traductologiques. Reposant sur

  1. Biogeochemical migration of heavy metals, Ti, V, Mo, Ta, W, and U, in the profile of a low-laid peatbog in the country between the Ob and Tom rivers

    International Nuclear Information System (INIS)

    Efremova, T.T.; Efremov, S.P.; Koutsenogii, K.P.; Peresedov, V.F.

    2003-01-01

    Biogeochemical migration of heavy metals in the course of marsh formation is mainly determined by physical-chemical processes, such as the oxidation-reduction zonality of the peatbog thickness and the state of humous substances (the quality of humus adsorptive barriers). In the process of peatbog formation V, U, Ta are the weakly captured elements while Mo is captured to a relatively higher extent. Elements as Ti and W are found in separate layers. No technogenic degradation of the marsh ecosystem in the Ob and Tom has been observed. (author)

  2. Ocena prostorske razsežnosti žledoloma februarja 2014 v bukovih in smrekovih sestojih v občinah Tolmin in Dobrova - Polhov Gradec s pomočjo tehnologije daljinskega zaznavanja

    OpenAIRE

    Šafran, Aljoša

    2018-01-01

    V magistrskem delu obravnavamo žledolom, ki je ob koncu januarja in začetku februarja 2014 povzročil gmotno škodo ne le na vegetaciji, temveč tudi na energetski in železniški infrastrukturi. Po dosedanjih ocenah gre za enega izmed najobsežnejših žledolomov na območju Slovenije v zadnjih desetletjih. V raziskavi nas je zanimala prostorska razporeditev sprememb v biomasi bukovih in smrekovih sestojev na z žledom prizadetih območjih, zaznanih s pomočjo satelita Landsat. V raziskavo sta bili zaje...

  3. Vitamin A decreases pre-receptor amplification of glucocorticoids in obesity: study on the effect of vitamin A on 11beta-hydroxysteroid dehydrogenase type 1 activity in liver and visceral fat of WNIN/Ob obese rats

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    Ayyalasomayajula Vajreswari

    2011-06-01

    Full Text Available Abstract Background 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1 catalyzes the conversion of inactive glucocorticoids to active glucocorticoids and its inhibition ameliorates obesity and metabolic syndrome. So far, no studies have reported the effect of dietary vitamin A on 11β-HSD1 activity in visceral fat and liver under normal and obese conditions. Here, we studied the effect of chronic feeding of vitamin A-enriched diet (129 mg/kg diet on 11β-HSD1 activity in liver and visceral fat of WNIN/Ob lean and obese rats. Methods Male, 5-month-old, lean and obese rats of WNIN/Ob strain (n = 16 for each phenotype were divided into two subgroups consisting of 8 rats of each phenotype. Control groups received stock diet containing 2.6 mg vitamin A/kg diet, where as experimental groups received diet containing 129 mg vitamin A/Kg diet for 20 weeks. Food and water were provided ad libitum. At the end of the experiment, tissues were collected and 11β-HSD1 activity was assayed in liver and visceral fat. Results Vitamin A supplementation significantly decreased body weight, visceral fat mass and 11β-HSD1 activity in visceral fat of WNIN/Ob obese rats. Hepatic 11β-HSD1 activity and gene expression were significantly reduced by vitamin A supplementation in both the phenotypes. CCAAT/enhancer binding protein α (C/EBPα, the main transcription factor essential for the expression of 11β-HSD1, decreased in liver of vitamin A fed-obese rats, but not in lean rats. Liver × receptor α (LXRα, a nuclear transcription factor which is known to downregulate 11β-HSD1 gene expression was significantly increased by vitamin A supplementation in both the phenotypes. Conclusions This study suggests that chronic consumption of vitamin A-enriched diet decreases 11β-HSD1 activity in liver and visceral fat of WNIN/Ob obese rats. Decreased 11β-HSD1 activity by vitamin A may result in decreased levels of active glucocorticoids in adipose tissue and possibly

  4. Sobre manhãs, humor e atos de fala

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    Joana Plaza PINTO

    Full Text Available RESUMO Este ensaio apresenta uma trajetória de leituras de Frege a Austin, intermediadas pela interpretação independente e ousada de Kanavillil Rajagopalan. Ao argumentar sobre uma gama de aproximações teóricas entre Frege e Austin, este ensaio narra a importância da interpretação de Rajagopalan para o debate sobre Austin no Brasil.

  5. Variaciones sobre el concepto de ética

    OpenAIRE

    Pérez Oliva, Elizabeth; Velasco, José Armando

    2007-01-01

    A lo largo de la historia, pensadores han dado ideas y teorías sobre la ética, pero todos concuerdan en que es una arte de la filosofía que trata de los actos morales, normas de conducta sobre el bien y el mal en el ser humano; término desarrollado a través del tiempo.

  6. Liberalismo versus republicanismo: notas sobre o conceito de liberdade.

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    Felipe Nunes

    2007-01-01

    Full Text Available Este artigo tem como objetivo contrastar as perspectivas liberal e republicana sobre o conceito de liberdade. Através da comparação feita entre os dois modelos tecemos considerações sobre a realidade brasileira tendo como foco o atual estado de crises advindas dos casos de corrupção no país.

  7. O DISCURSO OFICIAL SOBRE A CRIANÇA NO BRASIL

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    Carla Letuza Moreira e Silva

    2016-09-01

    Full Text Available Este estudo é um recorte da tese de doutoramento apresentada em 2012, no Programa de Pós-Graduação e Letras e Linguística da Universidade Federal de Alagoas (UFAL, em Maceió, sobre os discursos da/sobre a criança e as infâncias, no Brasil. O objetivo central é o de apresentar os efeitos de sentido que demandam dos dizeres oficiais no Estatuto da Criança e do Adolescente (ECA, 1990 em vigor no Brasil, sobre a criança, e que determinam modos de pensar e agir sobre as crianças e a infância na contemporaneidade. As noções de sujeito e formação discursiva da análise do discurso francesa (AD, iniciada em Pêcheux (1997, permeiam as análises e elucidam os papéis históricos e ideológicos que determinam e são determinados nos/pelos dizeres dos discursos da/sobre. Faz-se necessário, portanto, adentrar os discursos da e sobre a criança e a infância para entender as contradições e os confrontos dos discursos entre dizeres e silenciamentos.

  8. Reflexiones sobre Enfermería

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    Inés Durana Samper

    1992-12-01

    Full Text Available

    agosto 6 de 1992

    Presentación ante la Academia Nacional de Medicina
    Señores miembros de la Junta Directiva, académicos, enfermeras, señores, señoras:

    Introducción
    Para ingresar como Miembro Asociado de esta ilustre Academia Nacional de Medicina, quiero exponer algunas reflexiones sobre la evolución en Colombia de la enfermería, mi profesión, ejercida ininterrumpidamente en estos últimos cuarenta años. Amanera de colofón, me referiré a la función esencial de la enfermera, es decir a su consagración al arte de cuidar.

    La metodología aplicada en este trabajo incluye la revisión de archivos, la lectura de publicaciones y, además, algunas entrevistas con personas que pacientemente escucharon mis preguntas y ampliaron mi información con valiosos comentarios.

    Mis agradecimientos van, en primer término, al académico Fernando Serpa Flórez, quien ha tenido la iniciativa de presentarme a la Academia Nacional de Medicina; también va para aquellos académicos que respaldaron mi aceptación en esta prestigiosa sociedad científica. Igualmente expreso mi reconocimiento al académico Héctor Pedraza Mendoza, autor del primer libro conocido sobre reseña histórica de la enfermería en el país, y a quien correspondió, como funcionario de la administración pública, la orientación y control de la profesión en su cargo de Jefe de la División Infantil y Materna del entonces Ministerio de Trabajo, Higiene y Previsión Social. Libro citado con frecuencia’ durante el trabajo.

    Mis agradecimientos también a mis profesores, y entre ellos, en especial, al académico Alberto Albornoz- Plata. No puedo pasar por alto la memoria de los siempre recordados, doctores Jorge Boshell Manrique y José Pablo Leyva, quienes, desde la Escuela Superior de Higiene, supieron orientarme en la transformación académica del

  9. PROTOCOLO DE KYOTO: DEBATE SOBRE AMBIENTE Y DESARROLLO EN LAS DISCUSIONES SOBRE CAMBIO CLIMÁTICO

    Directory of Open Access Journals (Sweden)

    Rodríguez S. Liliana

    2008-07-01

    Full Text Available El comportamiento climático del planeta y sus consecuencias han propiciado debates sobre los modelos de desarrollo de los países responsables del deterioro acelerado del ambiente y de los fenómenos naturales por estos días recurrentes. Sin embargo, países como Estados Unidos, luego de firmar compromisos como la Convención sobre Cambio Climático, rehúsan adquirir las obligaciones del Protocolo de Kyoto, por temor a sufrir deterioro en sus economías. En este escenario, donde la nación responsable de la emisión de aproximadamente 36% de los gases efecto invernadero resultado de la acción humana en el planeta no se compromete a adoptar políticas restrictivas tendientes a hacer sus modelos de producción más amigables con la naturaleza a pesar de que dichas medidas empiezan a ser impuestas a otras naciones como condicionantes en las negociaciones comerciales internacionales, parece ser que la adopción del Protocolo de Kyoto para países en desarrollo como Colombia no es del todo benéfica.

  10. Sobre el genio de las mujeres

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    Valcárcel, Amelia

    1992-11-01

    Full Text Available Not available.

    A los varones, desde Tácito a Schopenhauer, nunca les ha parecido que las verdaderas mujeres son las que tienen en casa, sino las que tienen los otros varones (los germanos, los orientales. Por su parte, Wojtyla ha hecho profesión de fe «en el genio de las mujeres», reclutando enternecidos agradecimientos como el de Macciochi. La autora del presente artículo adopta una perspectiva histórica y una actitud analítica para aclarar qué es ese genio que como genérico nos adjudican. En primer lugar, la idea de genio es romántica y va emparejada con la de destino, sobre todo en el caso de los genios colectivos. Se trata de nociones que se construyen estipulativamente con fines pragmáticos y no admiten, por definición, contraejemplos. En el caso del genio de las mujeres, los llamados «valores femeninos» que lo constituyen pertenecen al ámbito de la Siulichkeit, y su eventual convalidación en el de la Moralitiit no puede obviar el proceso consistente en la crítica y el desmarcarse de una Sittlichkeit adjudicada como estereotipia que se contrasta, no con otra estereotipia simétrica, sino con lo universal, que se solapa con el genérico masculino. La autora, por último, nos recuerda que la fabricación de este genio que, a título de colectivo, se nos atribuye a las mujeres tiene lugar a costa de la usurpación de nuestra individualidad y de la ausencia de esquemas pragmáticos de reconocimiento de la genialidad individual que pueda producirse en el genérico femenino. Ahora bien: es esta última la que las mujeres necesitamos para poder romper con las tradiciones establecidas e instituir nuevos relatos.

  11. Construcciones en yeso proyectado sobre vegetales

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    Martínez, Hubert

    1986-07-01

    Full Text Available A construction method developed in early 1981 in Senegal, whose main objective is the evaluation of natural and human sources, specially those of wild vegetables and the phosphogypsum (a waste of chemical industry in Senegal. The introduction of the mechanical projection allows a noticeably growth in work performances and an improvement of the quality. The projection reduces de number of trades intervening in the work, doing away with plasters, watertightness systems and paintings, and simplifying the setting of technical installations and of carpentry. The acquisition of this projecting material is not very expensive, so, it is easy for small and medium enterprises to reach an expertness in gypsum work. Its finantial rentability is assured for a prize of the gypsum of 180% of the prize of the cement.Procedimiento de construcción desarrollado al comienzo de 1981 en el Senegal, teniendo como objetivo la valoración de las fuentes naturales y humanas, especialmente los vegetales en estado silvestre y el fosfoyeso, residuo de la industria química del Senegal. La introducción de la proyección mecánica permite aumentar sensiblemente el rendimiento del trabajo y mejorar la calidad. La proyección reduce el número de oficios que intervienen en la obra por la supresión de enlucidos, sistemas de estanquidad y pinturas sobre la gruesa obra y simplifica la colocación de las instalaciones técnicas y de carpintería. La adquisición del material de proyección, necesitando un capital relativamente modesto, se encuentra al alcance de pequeñas y medianas empresas que deseen especializarse en los trabajos de yeso. La rentabilidad financiera del procedimiento está asegurada para un precio del yeso de hasta el 180% del precio del cemento.

  12. Sobre el estado evolutivo de β Pictoris

    Science.gov (United States)

    Brunini, A.; Benvenuto, O. G.

    Desde el descubrimiento de fuertes excesos infrarrojos en β Pictoris, esta estrella ha sido muy estudiada y es considerada candidata a poseer un sistema planetario propio. β Pic está rodeada de un disco asimétrico de polvo que se observa de canto y que esta vacío a distancias de la presencia de (al menos) un planeta gigante. Recientemente se han observado líneas de material circunestelar que se han interpretado como consecuencia de la caída de objetos cometarios sobre esta estrella. Recientemente se ha utilizado la existencia del disco de polvo para atribuir una edad corta (pre - secuencia principal) a βPic. Sin embargo, la evaporación de estos cometas provee suficiente polvo como para explicar la presencia del disco observado sin necesidad de edades cortas. En este trabajo mostramos que la comparación entre la tasa de impactos cometarios estimada en el Sistema Solar para diferentes etapas de su evolución y los datos observados en β Pic indica edades avanzadas para β Pic. Esta estimación debe tomarse con cautela ya que depende de la estructura de los sistemas planetarios. Además mostramos que, desde el punto de vista de la evolución estelar y con las incertezas presentes en la luminosidad y la temperatura efectiva, existe un continuo de edades posible para β Pic. Sin embargo, empleando los datos provenientes de los flujos cometarios encontramos que una edad prolongada es consistente con ambos tratamientos.

  13. Considerações sobre o Mercosul

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    Ricardo Seitenfus

    1992-12-01

    Full Text Available Após traçar as origens históricas e conjunturais do processo de integração na Bacia do Prata, o autor analisa as características do Tratado de Assunção, através de um organograma detalhado. Na segunda parte, três questões sem resposta são colocadas aos leitores, ou seja, o processo de institucionalização envolvendo a constituição de um espaço supranacional que estará diretamente vinculado aos objetivos do processo; as relações do Mercosul com o Nafta e a definição de um quadro de cooperação e, finalmente, coloca a questão sobre o nível de participação do Estado no processo integracionista sob a ótica da necessidade de reconversão de certos setores econômicosIn the first part of this article, the author, after delineating the historical and circumstancial sources regarding the process of integration in the Prata Basin, analyses the characteristics of the Traty of Asunción (Paraguay through a detailed organizational chart. In the second part, three open questions are discussed: (a the process of institutionalization which involves the constitution of some supranationalization which invoves the constitution of some supranational space which will be closely related to the objectives of the process; (b the relationships between the Mercosul and the Nafta and the definition of a cooperative program; (c the level of participation of the State into the integrationist process under the dear need of a reconversion of some economic sectors.

  14. Estudio sobre encofrados de madera modernos

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    de la Peña Aznar, Juan M.

    1980-12-01

    Full Text Available The author continues the development of the subject «Modern Timber Formwork», by summing up the comparative examination —already carried out in Part III of this Study— of the different types of glued timber existing on the market. In addition, the loads and stresses allovk/able for coniferous timber and the proposal for establishing Regulations for the Timber Section of the Research and Experimental Forestry Institute of Spain are given. In part V of the author's Study, published in this article, the important subject of the glues used for joining timber, a truly vital point in order to obtain louvered timber beams which are simply glued together, is approached.

    El autor continúa el desarrollo del tema sobre «Encofrados de madera modernos», resumiendo el estudio comparativo —ya hecho en la Parte III de este Estudio— de las diferentes vigas de madera encolada existentes en el mercado dando, además, las cargas y tensiones admisibles para maderas coníferas y la propuesta de Reglamentación de la Sección de Maderas del Instituto Forestal de Investigaciones y Experiencias de España. En la parte V del Estudio del autor, publicada en este artículo, se aborda el importante tema de las colas empleadas para las uniones de madera, algo realmente vital para la obtención de vigas de madera en celosía simplemente encoladas.

  15. Perspectivas sobre la comunicación

    Directory of Open Access Journals (Sweden)

    María Luisa Naranjo Pereira

    2005-01-01

    Full Text Available Existen diversas teorías, enfoques y modelos de comunicación; de cada uno de ellos pueden rescatarse aspectos de gran valor para el logro de una comunicación eficaz. Este documento presenta una revisión de esos aspectos, para que se pueda comprender mejor y enriquecer uno de los procesos más importantes para el ser humano: el proceso de comunicación. Este es un ensayo en el cual se da a conocer la posición de la autora sobre el tema abordado. Se rescata el acento del enfoque humanista en la relación humana y en las etapas donde se desarrolla. A partir de la comunicación pragmática, se analizan los axiomas comunicacionales en que se fundamenta y lo que se conoce como patologías de esos axiomas. Además se revisan las principales características que distinguen la asertividad en la comunicación y las distintas formas de manipulación que la entorpecen. Del enfoque de Virginia Satir, se presentan los diversos aspectos de la comunicación, tanto funcional como disfuncional y los modelos de comunicación propuestos por esta autora. Se revisan aspectos importantes del enfoque de la comunicación educativa, tales como el control de la distancia, la voz y el cuerpo, las palabras y el situacional; así como los elementos que bloquean el proceso de comunicación y las sugerencias acerca de formas correctas de escuchar. Además, se hace referencia a la necesidad de emplear procesos educativos más holísticos y constructivistas y una comunicación-interrelación horizontal y con equidad.

  16. Reflexiones sobre las estrategias de desarrollo

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    Alberto Ortíz Gómez

    1991-05-01

    Full Text Available RESUMEN La apertura constituye actualmente el tema que mayor atención genera en los diversos círculos donde se debate si la condición  económica de la nación debe descansar en el modelo de sustitución de importaciones, debe residir en el fortalecimiento  de las exportaciones menores o debe definitivamente sustentarse en esfuerzos  integrados del aparato  gubernamental, el sistema financiero y la clase empresarial. Nadie discute la importancia de avanzar en pos de la actualización tecnológica, el incremento de los coeficientes de productividad, el mejoramiento de los niveles de calidad y la consecuente  intromisión de nuestra producción en los mercados internacionales. Frente a la necesidad de eliminar atávicas costumbres relacionadas con el pensar actuar en pequeño, vivir el pasado, aprovechar situaciones monopólicas de mercado y usufructuar el proteccionismo gubernamental, el remezón constitucional y la apertura en todos los órdenes de la vida nacional deben apuntar a un desarrollo de que participe de la colectividad en su conjunto. Sin embargo, en el convencimiento en las ventajas que plantean el nuevo esquema de desarrollo, es claro que existen dudas a espejar  e interrogantes no resueltos sobre la forma como deben articularse las  medidas económicas instauradas alrededor  de un proceso de apertura cuyos resultados no pueden analizarse con el criterio miope de quienes todo lo juzgan con base en la inmediatez.

  17. Estudos sobre a Esquistosomose em Pernambuco, Brasil

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    Aggeu Magalhães

    1940-01-01

    Full Text Available Os autores referem os resultados dos estudos sobre esquistosomose realisados, em Pernambuco, de Novembro de 1938 a Dezembro de 1939. Não se extendem em discussão, nem comentarios, tampouco, relacionam suas verificações com o que já foi relatado sobre o assunto em trabalhos nacionais e estrangeiros, pelo fato de que, não se trata de um resultado definitivo e sim de atividades que irão proseguir. Os estudos sistematicos em torno da endemia esquistosomica foram executados em duas localidades diversas pela população e pela situação geografica e ecologica. Pontezinha é uma povoação de 1200 habitantes localizada proximo a um conjunto de charcos e lagõas de agua dôce onde pululam caramujos do tipo olivaceus de Spix, e apresenta uma taxa de infestação de 21,4% para individuos do sexo masculino, e de 14,7% para os do sexo feminino. A distribuição por grupos de idade mostra que a incidencia cresce até o grupo de 16 a 20 anos de idade, quando atinge a percentagem de 37,8%, para decrescer em seguida. Em Vitoria a incidencia foi maior nos indivíduos do sexo feminino, atingindo a taxa de 41,4%, dando o sexo masculino a taxa de 36,9%. Por idade a percentagem maxima é atingida pelo grupo de 11 a 15 anos. Vitoria é uma cidade de 1500 habitantes, construida á margem do rio Tapacurá, onde se encontram numerosos caramujos do tipo centimetralis Lutz. A divergencia de incidencia corre por conta dos habitos da população e pela utilização que ela faz do rio, sendo maior em Vitoria porque a proximidade do rio facilita o uso de suas aguas para banho e serviços domesticos, condicionando este ultimo fato, a maior infestação das mulheres. O estudo da frequencia da infestação dos caramujos por cercarias de diversos trematodios, permite suspeitar uma relação inversa entre a taxa de infestação e o diametro maximo atingido pelos caramujos, parecendo este fato confirmar os trabalhos de Vianna Martins sobre a identidade dos hospedeiros

  18. A REVISED AGE FOR UPPER SCORPIUS AND THE STAR FORMATION HISTORY AMONG THE F-TYPE MEMBERS OF THE SCORPIUS-CENTAURUS OB ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Pecaut, Mark J.; Mamajek, Eric E.; Bubar, Eric J. [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627-0171 (United States)

    2012-02-20

    We present an analysis of the ages and star formation history of the F-type stars in the Upper Scorpius (US), Upper Centaurus-Lupus (UCL), and Lower Centaurus-Crux (LCC) subgroups of Scorpius-Centaurus (Sco-Cen), the nearest OB association. Our parent sample is the kinematically selected Hipparcos sample of de Zeeuw et al., restricted to the 138 F-type members. We have obtained classification-resolution optical spectra and have also determined the spectroscopic accretion disk fraction. With Hipparcos and 2MASS photometry, we estimate the reddening and extinction for each star and place the candidate members on a theoretical H-R diagram. For each subgroup we construct empirical isochrones and compare to published evolutionary tracks. We find that (1) our empirical isochrones are consistent with the previously published age-rank of the Sco-Cen subgroups; (2) subgroups LCC and UCL appear to reach the main-sequence turn-on at spectral types {approx}F4 and {approx}F2, respectively. An analysis of the A-type stars shows US reaching the main sequence at about spectral type {approx}A3. (3) The median ages for the pre-main-sequence members of UCL and LCC are 16 Myr and 17 Myr, respectively, in agreement with previous studies, however we find that (4) Upper Sco is much older than previously thought. The luminosities of the F-type stars in US are typically a factor of {approx}2.5 less luminous than predicted for a 5 Myr old population for four sets of evolutionary tracks. We re-examine the evolutionary state and isochronal ages for the B-, A-, and G-type Upper Sco members, as well as the evolved M supergiant Antares, and estimate a revised mean age for Upper Sco of 11 {+-} 1 {+-} 2 Myr (statistical, systematic). Using radial velocities and Hipparcos parallaxes we calculate a lower limit on the kinematic expansion age for Upper Sco of >10.5 Myr (99% confidence). However, the data are statistically consistent with no expansion. We reevaluate the inferred masses for the known

  19. The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role

    International Nuclear Information System (INIS)

    Krishna, S. Sri; Aravind, L.; Bakolitsa, Constantina; Caruthers, Jonathan; Carlton, Dennis; Miller, Mitchell D.; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L; Chiu, Hsiu-Ju; Clayton, Thomas; Deller, Marc C.; Duan, Lian; Feuerhelm, Julie; Grant, Joanna C.; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Kumar, Abhinav; Marciano, David; McMullan, Daniel; Morse, Andrew T.; Nigoghossian, Edward; Okach, Linda; Reyes, Ron; Rife, Christopher L.; Bedem, Henry van den; Weekes, Dana; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Elsliger, Marc-André; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

    2010-01-01

    The crystal structure of SSO2064, the first structural representative of Pfam family PF01796 (DUF35), reveals a two-domain architecture comprising an N-terminal zinc-ribbon domain and a C-terminal OB-fold domain. Analysis of the domain architecture, operon organization and bacterial orthologs combined with the structural features of SSO2064 suggests a role involving acyl-CoA binding for this family of proteins. SSO2064 is the first structural representative of PF01796 (DUF35), a large prokaryotic family with a wide phylogenetic distribution. The structure reveals a novel two-domain architecture comprising an N-terminal, rubredoxin-like, zinc ribbon and a C-terminal, oligonucleotide/oligosaccharide-binding (OB) fold domain. Additional N-terminal helical segments may be involved in protein–protein interactions. Domain architectures, genomic context analysis and functional evidence from certain bacterial representatives of this family suggest that these proteins form a novel fatty-acid-binding component that is involved in the biosynthesis of lipids and polyketide antibiotics and that they possibly function as acyl-CoA-binding proteins. This structure has led to a re-evaluation of the DUF35 family, which has now been split into two entries in the latest Pfam release (v.24.0)

  20. As vicissitudes do "ensaio sobre o dom"

    Directory of Open Access Journals (Sweden)

    Lygia Sigaud

    1999-10-01

    Full Text Available A partir dos anos 60, antropólogos de diferentes tradições nacionais passaram a convergir no sentido de considerar que o texto de Marcel Mauss, "Ensaio sobre o Dom", contivesse uma teoria da troca, que atribui à identificação entre a coisa dada e o espírito do doador o princípio de explicação das transações. Esta interpretação contrasta com a que tiveram os contemporâneos de Mauss, os quais resgataram do trabalho suas dimensões relativas ao direito, às obrigações e às prestações totais. Partindo desta constatação, o artigo problematiza o destino do ensaio e busca torná-lo inteligível. Para tanto examina as condições sociointelectuais que contribuíram para que se produzisse a inflexão na leitura e a consolidação de uma espécie de crença coletiva em relação ao trabalho. Através deste estudo de caso, a autora identifica mecanismos que operam no processo de construção de teorias, na conformação de representações acerca de textos e na sua consagração no âmbito da antropologia.From the 1960s, anthropologists of different national traditions came to share the view that Marcel Mauss’s text, "Essay on the Gift," contained a theory of exchange which takes the identification between the thing given and the spirit of the donor as the explanatory principle of transactions. This interpretation contrasts with that held by Mauss’s contemporaries, who lifted from the work aspects relating to law, obligations and total prestations. Starting from this fact, the article problematizes the essay’s fate and seeks to make it intelligible. To this end, it examines the socio-intellectual conditions which contributed to producing this inflection in the readings of the work and the consolidation of a kind of collective belief concerning it. Through this case study, the author identifies mechanisms which operate in the process of constructing theories, in the conformity found in representations of certain texts, and in the

  1. ESTUDO PROSPECTIVO SOBRE ENCAPSULAMENTO DE COMPOSTOS BIOATIVOS

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    Larissa Assunção

    2014-12-01

    Full Text Available Com o advento da nanotecnologia, houve o desenvolvimento de técnicas envolvendo processamento, fabricação e aplicação de estruturas, com forma e tamanho controlados, sendo que na indústria de alimentos, estas formulações, tanto na faixa micrométrica como nanométrica, vêm sendo utilizadas com o objetivo de favorecer o produto final. Tendo em vista a importância tecnológica dessa técnica e do grande interesse nacional e internacional, principalmente no ramo da indústria alimentícia, sobre os benefícios do encapsulamento, o presente estudo prospectivo teve como objetivo avaliar o panorama mundial relativo ao tema em questão, correlacionando-o com os documentos de patentes depositados. Para tanto, realizou-se uma pesquisa das patentes na base de dados europeia Espacenet®, utilizando os descritores do tema em estudo associados aos códigos de classificação. As informações encontradas foram compiladas em gráficos e discutidas. Pôde-se observar que o maior número de patentes referiu-se ao código A23L1/00 - alimentos ou produtos alimentícios: a sua preparação ou tratamento e houve um crescimento exponencial em relação ao depósito de patentes nos últimos 10 anos, sendo os Estados Unidos o país líder em número de patentes depositadas (60%. A Firmenich e CIE lidera o ranking com mais patentes depositadas. Em relação à área de atuação, predomina a indústria alimentícia (69%. No que diz respeito ao Brasil, o país aparece com apenas 1 patente detentora desta tecnologia, sendo um número bastante reduzido o que mostra a falta de incentivo neste setor. Diante dos resultados obtidos, concluiu-se que, apesar de ser uma tecnologia recente, observa-se uma tendência ao crescimento de depósito de patentes.

  2. CONSIDERACIONES SOBRE EDUCACION MEDICA y SALUD

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    Jaime Escobar Triana

    1984-11-01

    Full Text Available

    l. Los cambios, las corrientes migratorias internas, transformaron un país de población rural en urbana, al mismo tiempo con un epifenómeno de ruralización de la ciudad. De un 700/0 de población rural se pasó a un 700/0 o más y con tendencia a umentar la población urbana. Esto lleva a un replanteamiento en la atención de la salud. Además, se suma a lo anterior, la información masiva sobre la población que alienta la posibilidad de alcanzar
    tratamientos y drogas maravillosas o recursos extraordinarios como las unidades de cuidados intensivos o los transplantes, para dar dos ejemplos, que motivan al público a demandar dichos servicios. De otra parte, la misma información científica que alcanza
    apabullantes cantidades, solamente permite que el médico logre obtenerla y asimilarla en forma limitada y angustiante para su aplicación práctica.

    2. En la creación de nuevas Escuelas de Medicina deben considerarse entre otros los siguientes hechos o factores, favorables o desfavorables que no sólo afectan a Colombia sino que tienen características universales en algunos de sus aspectos:
    a La demanda de cupos en educación superior, entre ellos la medicina, nunca satisfecha.
    b Las presiones sociales que tienen el estudio como un método de ascenso por prestigio local o regional o político o todos juntos y no por la necesidad de formar más médicos.
    c La inconveniencia de la masificación de la educacación médica que demerita la calidad y por tanto es preferible el crear nuevas escuelas con número limitado de estudiantes que permitan una alta calidad de formación.
    d La dificultad de modificar los curricula tradicionales establecidos que impiden actualizar la docencia a las circunstancias que vive y requiere la salud del país.
    e La politización de las universidades públicas que demeritan la actividad docente al imponerse condiciones extrauniversitarias en la formación y realización de

  3. Notas sobre fiebre amarilla en Colombia

    Directory of Open Access Journals (Sweden)

    Luis Patiño Camargo

    1937-09-01

    Full Text Available I-Introducción ll.-Datos clínicos anteriores al período de las investigaciones de laboratorio. Época colonial. III-Período de laboratorio anterior al descubrimiento de los animales receptivos. IV.-Período posterior al descubrimiento de los animales receptivos y a la prueba de protección. V.-Trabajos en Colombia durante el período de las investigaciones. VI. El servicio de fiebre amarilla cooperativo entre el Departamento Nacional de Higiene y la Fundación Rockejeller. VIl.-Consideraciones generales. VIlI.-Conclusiones. IX-Recomendaciones. X. Agradecimientos. XI.-Bibliografía. XIl.-Anexos. Legislación sobre viscerotomía. Es de fundamental interés para la vida de la República el estudio y solución de los problemas que se refieren a la salud de sus habitantes; y como el territorio colombiano es cálido en su mayoría, lógicamente se concluye que los asuntos de patología tropical han de ser los primeros en orden de importancia. La fiebre amarilla ha revestido graves caracteres epidémicos en repetidas épocas y por su condición endémica en anchas zonas del territorio colombiano, es una constante amenaza pública; un estudio para conocer su historia, la aparición de los brotes epidémicos, su distribución geográfica, la incidencia de morbosidad y Ietalidad, la localización precisa y la extensión de los territorios afectados, las fuentes del virus y los agentes transmisores, así como la preparación de planes y programas de lucha contra el flagelo, son cuestiones tan interesantes que basta anunciarlas para reconocer su trascendencia. En el deseo de contribuír modestamente al desarrollo de tal programa, he recogido los apuntes cuya exposición forma el presente trabajo.

  4. Reflexiones sobre la anorexia Reflexões sobre a anorexia Reflections about anorexy

    Directory of Open Access Journals (Sweden)

    Andrea Ferrero

    2009-03-01

    Full Text Available El propósito de este artículo es presentar algunas reflexiones sobre el trastorno anoréxico, algunas posibles explicaciones sobre el mismo, y proponer una respuesta posible desde la perspectiva psicoanalítica. Este estudio plantea el sufrimiento del sujeto como la manifestación de una relación inconsciente entre las ecuaciones afectivas y el entramado social de la persona. Se discute la particular relación que se establece entre la necesidad, la demanda y el deseo en este tipo de trastornos, y cómo el síntoma anoréxico se plantea como estrategia enferma de defensa del deseo. Se puede considerar el impacto que la presión de la cultura tiene en la manutención del síntoma anoréxico, dada la importancia del ideal de delgadez y belleza, también asociados con la obtención de mayor éxito y felicidad. Finalmente, se plantea el valor del análisis de la personalidad en relación a aspectos sociales para la consideración del trastorno anoréxico, el cual debe ser comprendido singularmente, más allá de sus manifestaciones y de la posible limitación a la estructura de la histeria.O objetivo deste artigo é apresentar algumas reflexões sobre o processo de adoecimento da anorexia e algumas possíveis explicações sobre esse processo, bem como propor uma possível resposta a partir da perspectiva psicanalítica. Este estudo estabelece o sofrimento do sujeito como a manifestação da relação inconsciente entre as equações afetivas e a trama social da pessoa. Procura-se discutir a peculiar relação entre necessidade, demanda e desejo neste tipo de transtorno, e como a anorexia é uma estratégia patológica de defesa do desejo. Pôde-se observar a influência da pressão da cultura na manutenção da anorexia, justificada pelo ideal de magreza e de beleza, que também são associadas com a possibilidade de obter maior êxito e felicidade. Por último, considera-se o valor da análise da personalidade em relação aos aspectos sociais

  5. Comentarios sobre la Ley de Ordenamiento Territorial Sostenible

    Directory of Open Access Journals (Sweden)

    Arturo J. Yglesias

    2014-04-01

    Full Text Available La denominada Ley de Ordenamiento Territorial Sostenible, no fue bien recibida en el medio jurídico. Tanto los profesores de las diferentes materias de Derecho de nuestra Facultad como las asociaciones profesionales y otros grupos e juristas de nuestro medio, formularon reservas de diverso calibre sobre el texto de la ley que van desde sus aspectos adjetivos como la terminología y redacción hasta cuestiones sustanciales como lo que ella dice sobre el régimen de la propiedad territorial y otras cuestiones vinculadas.Desde el discurso político vimos lanzar opiniones iracundas y alarmistas sobre las modificaciones que la ley estaría haciendo al régimen de la propiedad privada, sobre su supuesta inconstitucionalidad.Nosotros nos vamos a referir a la ley a sus antecedentes y de las críticas que se le hacían, en la parte que toca a nuestra materia, esto es en lo relativo al régimen de la propiedad y debemos decir, a vía de adelanto, que no vemos en ella nada que afecte el derecho de propiedad consagrado por la Constitución de la República, ni los principios generales que regulan la propiedad territorial conforme al Código Civil, conforme a la vieja ley de Centros Poblados, sus modificativas ni demás normas sobre la materia.

  6. Perspectivas sobre la comunicación

    Directory of Open Access Journals (Sweden)

    Naranjo Pereira, María Luisa

    2005-12-01

    Full Text Available Existen diversas teorías, enfoques y modelos de comunicación; de cada uno de ellos pueden rescatarse aspectos de gran valor para el logro de una comunicación eficaz. Este documento presenta una revisión de esos aspectos, para que se pueda comprender mejor y enriquecer uno de los procesos más importantes para el ser humano: el proceso de comunicación. Este es un ensayo en el cual se da a conocer la posición de la autora sobre el tema abordado. Se rescata el acento del enfoque humanista en la relación humana y en las etapas donde se desarrolla. A partir de la comunicación pragmática, se analizan los axiomas comunicacionales en que se fundamenta y lo que se conoce como patologías de esos axiomas. Además se revisan las principales características que distinguen la asertividad en la comunicación y las distintas formas de manipulación que la entorpecen. Del enfoque de Virginia Satir, se presentan los diversos aspectos de la comunicación, tanto funcional como disfuncional y los modelos de comunicación propuestos por esta autora. Se revisan aspectos importantes del enfoque de la comunicación educativa, tales como el control de la distancia, la voz y el cuerpo, las palabras y el situacional; así como los elementos que bloquean el proceso de comunicación y las sugerencias acerca de formas correctas de escuchar. Además, se hace referencia a la necesidad de emplear procesos educativos más holísticos y constructivistas y una comunicación-interrelación horizontal y con equidad. Each of the diverse theories, approaches, and models of communication can provide valuable elements for the attainment of effective communication. This article presents a review of those elements with the goal of providing a better understanding and enhancement of one of the most important processes for human beings: the process of communication. This essay presents the author´s position on the topic. The importance given to human relationships and the stages

  7. Efeitos dos choques fiscais sobre o mercado de trabalho brasileiro

    Directory of Open Access Journals (Sweden)

    Diogo Baerlocher Carvalho

    2013-06-01

    Full Text Available Esse trabalho tem por objetivo entender quais os efeitos dos choques fiscais sobre o mercado de trabalho brasileiro. Em particular, utiliza se uma abordagem SVAR para avaliar esses efeitos sobre o emprego e o salário real. Os choques fiscais são identificados a partir da imposição de restrições de sinais puras sobre a relação dinâmica entre os gastos do governo, o produto real e a oferta de trabalho. As restrições são obtidas a partir de funções de resposta a impulso Bayesianas derivadas de um modelo DSGE na tradição da Nova Síntese Neoclássica. As funções de resposta a impulso obtidas a partir da abordagem SVAR mostram que choques fiscais aumentam o salário real e o emprego.

  8. Deformaciones faciales y sus influencias sobre el psiquismo

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    Guillermo Nieto Cano

    1957-04-01

    Full Text Available Creemos haber dejado establecido, en síntesis, que todas las minusvalías físicas repercuten sobre el psiquismo, y que entre éstas las deformaciones faciales, por su ostentosa evidencia, son las que afectan más seriamente al individuo y modifican por eso más radicalmente su conducta, incidiendo así, en forma trascendental, sobre la colectividad. Tales defectos constituyen, por consiguiente, un serio problema humano, cuyo estudio y remedio incumbe no solamente al esteta cirujano, sino que interesa a todos aquellos que puedan influir sobre la estabilidad armónica y la buena marcha de la sociedad en que viven.

  9. Revisitando uma carta em português sobre Sabbatai Zvi

    Directory of Open Access Journals (Sweden)

    Rodrigues da Silva Tavim, José Alberto

    2007-06-01

    Full Text Available The present paper deals with the Iberian context of the production-translation of a text in Portuguese language about Shabbatai Zevi, in 1666. We refer the production of similar texts and the information about the adherents in Spain, mostly in Malaga. We reflect on the various messsianic currents that crossed the different social groups in Portugal. We present a text that proves the spreading of news about Shabbatai in Portuguese Lands, and the interest kindled among the Portuguese Conversos. And we place the hypothesis that this text to the movement of Shabbatai, could have different readings, among them one that could be convenient to the conversos.

    Este artículo aborda el contexto de la producción-traducción de un texto en portugués sobre Sabetay Sebí, en 1666. Se alude a la producción de otros textos similares y a la información sobre los adeptos del movimiento en España, sobre todo en Málaga. Se reflexiona sobre las varias corrrientes mesiánicas que cruzaban los diferentes grupos sociales en Portugal. Se presenta un texto que prueba la divulgación de noticias sobre Sabetay, en tierras portuguesas y del interés desperttado entre los medios conversos sobre el movimiento. Y se plantea la hipótesis de que este texto contrario al movimiento de Sabbatai pudiera tener varias lecturas, entre ellas una que debería ser conveniente para los conversos.

  10. Pequena monografia sobre o Rio Grande do Sul

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    Ana Maria Pinho

    2014-05-01

    Full Text Available Pequena monografia desenvolvida por membros do Colégio Sevigne, que versa sobre diversos assuntos a respeito do Rio Grande do Sul, divididos em histórico, fronteiras, organização política administrativa, características geográficas, formação geomorfológica, economia, aspectos históricos e geográficos da capital do Estado, generalidades étnicas, e sobre o gaúcho em si. Grande quantidade de ilustrações e poemas enriquecem o artigo.

  11. Teorias sobre o amor no campo da Psicologia Social

    OpenAIRE

    Martins-Silva, Priscilla de Oliveira; Trindade, Zeidi Araujo; Silva Junior, Annor da

    2013-01-01

    Este é um ensaio teórico sobre o fenômeno amor em relacionamentos românticos no campo da Psicologia e no da Psicologia social. São apresentadas as primeiras teorias sobre o amor na Psicologia, e, posteriormente, são abordadas em maior profundidade três teorias da Psicologia social: os estilos de amor de John Alan Lee, a teoria de apego, de Phillip Shaver, Cindy Hazan e Donna Bradshaw, e a teoria triangular do amor, de Robert J. Sternberg. São apresentados os aspectos teóricos, empíricos e met...

  12. La literatura comparada sobre reformas administrativas: Desarrollos, limitaciones y posibilidades

    OpenAIRE

    Dussauge Laguna, Mauricio I.

    2009-01-01

    Durante las últimas dos décadas, la literatura comparada sobre reformas administrativas ha crecido significativamente. ¿Cuáles han sido sus aportaciones y cuáles sus limitaciones? ¿Qué nos queda por aprender sobre el tema? Este ensayo repasa los debates centrales de la literatura, analiza sus principales debilidades y sugiere un conjunto de futuras líneas de investigación. El argumento central del ensayo es que la literatura comparada en esta materia ha avanzado en forma considerable en térmi...

  13. Nuevos documentos sobre Rojas Zorrilla y su teatro

    Directory of Open Access Journals (Sweden)

    Madroñal, Abraham

    2007-06-01

    Full Text Available This article contains twelve unpublished documents on Rojas Zorrilla, related to his biography and literary works (comedias and autos sacramentales. The majority are handwritten by the poet himself, and they provide new information relevant to our knowledge of his life and to the understanding of his works.Se publican una docena de documentos inéditos sobre Rojas Zorrilla referidos a su biografía y a algunas comedias y autos. En buena parte dichos documentos son autógrafos del poeta y añaden o matizan informaciones concretas sobre él y sus obras.

  14. EFECTOS DEL MERCURIO SOBRE ALGUNAS PLANTAS ACUÁTICAS TROPICALES

    OpenAIRE

    Posada, Martha Isabel; Arroyave, María del Pilar

    2006-01-01

    El presente artículo es una descripción de los efectos del mercurio sobre algunas plantas acuáticas tropicales y sobre los ecosistemas donde habitan. Adicionalmente, se recomienda un protocolo para realizar pruebas de toxicidad con la lenteja de agua (Lemna minor) y se presentan los resultados de los preensayos con diferentes concentraciones de sales de mercurio en condiciones de laboratorio. Se encontró que la biodisponibilidad del mercurio depende de factores que facilitan la disolución del...

  15. Santa sexualidad: concepciones de dos monjas sobre Feminidad y sexualidad

    OpenAIRE

    Giraldo Quijano, Isabel Cristina

    2009-01-01

    En el contexto de la religión católica, la feminidad y la sexualidad femenina se configuran según dogmas y representaciones sociales específicos, en los que la imagen de Cristo -y todo lo que ello implica- actúa como elemento fundamental en la construcción de las concepciones de las mujeres consagradas a la vida religiosa sobre sex ualidad, erotismo, cuerpo. amor. Este artículo pretende explorar desde un punto de vista sociológico las concepciones de dos monjas sobre los temas mencionados....

  16. Contexto y pensamiento de Charles Taylor sobre el consenso

    Directory of Open Access Journals (Sweden)

    Doris Elena Ospina Muñoz

    2017-01-01

    Full Text Available El artículo sostiene que el consenso no es un tema de primer orden en la filosofía política de Charles Taylor, pero una lectura orientada al problema puede ofrecer los elementos para establecer una teoría sobre dicha noción e identificar los argumentos para su justificación. Además, se enfatiza en el contexto de discusión que permite introducir la filosofía de Taylor como un modo de pensar sobre el consenso, alternativo al constructivismo.

  17. (I) Informe sobre conflicto violento en colombia (2011–2012)

    OpenAIRE

    2014-01-01

    Las negociaciones de paz entre el gobierno nacional y las FARC avanzan de modo considerable. Al momento del cierre del presente informe –julio de 2014–, se construyó un acuerdo sobre los tres primeros puntos de la agenda –la reforma agraria, la participación política y las drogas ilícitas–. Sin duda la negociación progresa, los puntos sobre los que se trazó un acuerdo tocan dimensiones neurálgicas de la vida colectiva: el agro y su atraso histórico, la democracia y sus cierres, el narcotráfic...

  18. Reflexiones sobre la corrupción y su impacto sobre la salud

    Directory of Open Access Journals (Sweden)

    Alfredo Jácome Roca

    2017-04-01

    Existe una gran variedad de teorías biológicas, psicológicas, sociológicas y económicas que explican la conducta corrupta, algunas de las cuales profundizan sobre cómo las prácticas generalizadas de violación de las reglas pueden afectar la honestidad individual y la voluntad intrínseca de seguir las leyes. Así, por ejemplo, hay quienes sostienen que el engaño es común en el mundo animal y hace parte del proceso evolutivo; en ese sentido, se considera como un acto natural, innato y que responde a la lucha por la supervivencia. Por eso, se encuentran especies que se camuflan, se mimetizan, se hacen las muertas, utilizan químicos que no permiten ver la gravedad de un ataque, consiguen que el competidor las considere más grandes de lo que realmente son adoptando ciertas posturas, etc.

  19. SOBRE LA PAZ Y LOS DIÁLOGOS. CONSIDERACIONES SOBRE EL PAPEL DE LA SOCIEDAD CIVIL

    Directory of Open Access Journals (Sweden)

    William Ortiz Jiménez

    2014-10-01

    Full Text Available El ensayo hace una reflexión en torno al proceso de paz que se llevó a cabo en el gobierno del presidente Andrés Pastrana, y la participación que tuvo la sociedad civil en este asunto. Pero, trasciende, además, a la situación actual del conflicto en Colombia. A partir de las formulaciones de varios teóricos, entre los que se destacan Daniel Pécaut, Cohen, y Arato., Margarita Bonamusa, María Teresa Uribe, Daniel García-Peña, Habermas, Rawls, entre otros, se fortalece un marco teórico y de referencia bastante sólido para mostrar cómo lo público es indispensable en las acotaciones que lleven a la solución de los conflictos. Sin el concurso de lo público, tampoco sería viable la participación de la sociedad civil. Los espacios de solución de conflictos, el ágora, en palabras de Hanna Arendt, es el lugar esencial para la discusión, el consenso y los acuerdos. En política, la esfera de lo público prima sobre lo privado, porque el reconocimiento de las libertades, manifestaciones y la plenitud de los derechos sólo se logra en lugares comunes.

  20. Construcciones sociales sobre mujeres desde el discurso jurídico en sentencias penales sobre infanticidio

    Directory of Open Access Journals (Sweden)

    María Eugenia Gastiazoro

    2015-12-01

    Full Text Available El infanticidio como figura penal se suprime del Código Penal Argentino en 1994, para ser una figura de homicidio agravado por el vínculo con prisión o reclusión perpetua. Diez años después de su última derogación, el caso Romina Tejerina en Jujuy generó una serie de cuestionamientos respecto de su penalización. Otro caso, que tomó estado público fue el de Eli Díaz en la ciudad de Villa Dolores en Córdoba, juzgada en el 2006, siendo (en contraposición al caso Tejerina absuelta por una mayoría compuesta solo de ciudadanos comunes (jurados. En el presente trabajo se analiza la construcción y la producción que desde el discurso jurídico se hace de las diferentes mujeres en los casos de infanticidio. A su vez, estas imágenes se comparan con las representaciones que los legisladores tuvieron en el debate del Congreso del año 2010 cuando se intentó reponer la figura. La sujeción del género centrada en la buena o mala madre, mujer, esposa, en intersección con otras dimensiones de clase social, y edad, se categoriza en el discurso de los tribunales de acuerdo a imaginarios sociales que sostienen una identidad normativa sobre estas mujeres.

  1. Una mirada sobre lo popular. Reflexiones sobre el etnocentrismo en el nuevo cine argentino

    Directory of Open Access Journals (Sweden)

    Gonzalo Assusa

    2013-01-01

    Full Text Available La emergencia del nuevo cine argentino desata una serie de debates teóricos. Probablemente una de las caracterizaciones más convincentes es la que lo define como surgido de una misma crisis, no sólo en el campo cinematográfico, sino también de una misma crisis social. En el marco de un análisis sociológico de este fenómeno cultural, el presente trabajo planteará una hipótesis de lectura para algunas de las producciones audiovisuales del denominado nuevo cine argentino, en pos de establecer conceptualmente la estructuración desde el polo productivo de la elaboración imaginaria de esta crisis social, concretamente, de la emergencia de las clases populares en sus filmes. Para finalizar, se evaluará la productividad de la hipótesis de lectura basada en una definición teórica de lo popular, aplicándola a un cuerpo de filmes del realizador argentino Adrián Caetano, para concluir con reflexiones sobre la importancia del cruce entre la estructuración textual y la estructuración en el momento del consumo.

  2. Economic Aspects of Radiation Treatment; Considerations Economiques sur le Traitement par Irradiation; Ehkonomicheskie aspekty obrabotki produktov metodom oblucheniya; Consideraciones Economicas Sobre el Tratamiento por Irradiacion

    Energy Technology Data Exchange (ETDEWEB)

    Leveque, P. [Centre d' Etudes Nucleaires de Saclay (France)

    1966-11-15

    pudieron sacar varias conclusiones sobre el costo del tratamiento por medio de fuentes radiactivas y maquinas. Es conveniente, tres aflos despues, revisar las hipotesis fundamentales y, sobre todo, tener en cuenta el abaratamiento de los radioelementos, en particular, del {sup 137}Cs. Esto influye a la vez sobre el precio del kilovatio instalado y del kilovatio-hora de energfa producido. La experiencia adquirida en estos tres ultimos aflos permite precisar los rendimientos y factores de carga observados en instalaciones actualmente en servicio. Es cierto que en la mayorfa de los casos estas consisten en instalaciones de tratamiento de accesorios medicos, pero los problemas son analogos. (author) [Russian] V mae 1963 goda vo vremja raboty Konferencii po promyshlennomu primeneniju moshhnyh istochnikov izluchenija, organizovannoj MAGATJe, razvernulas' bol'shaja diskussija po voprosu sebestoimosti. V rezul'tate obmena mnenijami mozhno sdelat' nekotorye ocenki stoimosti obrabotki radioaktivnymi istochnikami i ustrojstvami. Zhelatel'no po istechenii treh let peresmotret' osnovnye gipotezy i uchest' snizhenie stoimosti radiojelementov, i v osobennosti cezija-137. Stoimost' radiojelementov okazyvaet vlijanie srazu na stoimost' 1 kvt ustanovlennoj moshhnosti i kilovatt/chasa proizvodimoj jelektrojenergii. V svete poluchennogo v techenie poslednih treh let opyta imeetsja vozmozhnost' utochnit' proizvoditel'nost' i kojefficient nagruzki dejstvujushhih v nastojashhee vremja ustanovok; Rech' idet v bol'shinstve sluchaev ob obrabotke vspomogatel'nogo medicinskogo oborudovanija, no vse jeti problemy sravnimy. (author)

  3. RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain.

    Science.gov (United States)

    Pavani, R S; Fernandes, C; Perez, A M; Vasconcelos, E J R; Siqueira-Neto, J L; Fontes, M R; Cano, M I N

    2014-12-20

    Replication protein A-1 (RPA-1) is a single-stranded DNA-binding protein involved in DNA metabolism. We previously demonstrated the interaction between LaRPA-1 and telomeric DNA. Here, we expressed and purified truncated mutants of LaRPA-1 and used circular dichroism measurements and molecular dynamics simulations to demonstrate that the tertiary structure of LaRPA-1 differs from human and yeast RPA-1. LaRPA-1 interacts with telomeric ssDNA via its N-terminal OB-fold domain, whereas RPA from higher eukaryotes show different binding modes to ssDNA. Our results show that LaRPA-1 is evolutionary distinct from other RPA-1 proteins and can potentially be used for targeting trypanosomatid telomeres. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  4. Concentration urinaire de bisphénol A et obésité chez les adultes : résultats de l’Enquête canadienne sur les mesures de la santé

    Directory of Open Access Journals (Sweden)

    Minh T. Do

    2017-01-01

    Full Text Available Introduction : Des études chez l’animal ont révélé que l’exposition au bisphénol A (BPA affecte le métabolisme des lipides et favorise la prise de poids. Des études épidémiologiques récentes appuient aussi l’existence d’un lien entre le BPA et l’obésité chez l’humain, mais la plupart d’entre elles se limitent à une seule mesure de l’adiposité ou ne tiennent pas compte des facteurs de confusion alimentaires possibles. Cette étude vise à examiner les associations entre les concentrations urinaires de BPA et les mesures de l’adiposité dans un échantillon national représentatif des adultes canadiens. Méthodologie : Nous avons réalisé des analyses à l’aide de données de biosurveillance et de données anthropométriques mesurées directement auprès de 4 733 adultes de 18 à 79 ans dans le cadre de l’Enquête canadienne sur les mesures de la santé (2007-2011. Nous avons utilisé des modèles de régression logistique multinomiale et binaire pour estimer les associations entre, d’une part, les concentrations urinaires de BPA et, d’autre part, les diverses catégories d’indice de masse corporelle (IMC (embonpoint par opposition à poids insuffisant ou normal; obésité par opposition à poids insuffisant ou normal et un tour de taille élevé (102 cm ou plus pour les hommes; 88 cm ou plus pour les femmes en tenant compte des facteurs de confusion possibles. Des analyses de régression linéaire ont aussi été effectuées pour évaluer les associations entre les concentrations urinaires de BPA et des mesures de l’IMC et du tour de taille. Résultats : On a pu associer positivement la concentration urinaire de BPA et l’obésité (définie par l’IMC. Le rapport de cotes s’est situé à 1,54 (intervalle de confiance [IC] à 95 % : 1,002 à 2,37 dans le quartile de BPA le plus élevé par rapport au plus bas (test de tendance, p = 0,041. La concentration urinaire de BPA n’a pas été associ

  5. Late Paleozoic closure of the Ob-Zaisan Ocean along the Irtysh/Chara shear zone and implications for arc amalgamation and oroclinal bending in the western Central Asian Orogenic Belt

    Science.gov (United States)

    Li, Pengfei; Sun, Min; Rosenbaum, Gideon

    2016-04-01

    The Irtysh/Chara Shear Zone is one of the largest strike-slip systems in the Central Asian Orogenic Belt (CAOB). It records collisional processes of the peri-Siberian orogenic system with the West Junggar-Kazakhstan-Tianshan orogenic system following the closure of the Ob-Zaisan Ocean, but the exact timing of these events remains enigmatic. We conducted detailed structural analysis along the Irtysh Shear Zone (NW China), which together with new geochronological data allows us to reconstruct the tectonic evolution during the final closure of the Ob-Zaisan Ocean. Our results showed that subduction-accretion processes lasted at least until the Late Carboniferous in the Chinese Altai and the East/West Junggar. The subsequent arc amalgamation is characterized by a cycle of crustal thickening, orogenic collapse and transpressional thickening. On a larger scale, the West Junggar- Kazakhstan -Tianshan orogenic system defines a U-shape oroclinal structure (e.g. Xiao et al., 2010). A major phase of oroclinal bending that involved ~110° rotation may have occurred during the Late Devonian to Early Carboniferous (Levashova et al., 2012). Previous authors have linked oroclinal bending with the late Paleozoic amalgamation of the western CAOB, and proposed that a quasi-linear West Junggar- Kazakhstan -Tianshan orogenic system was buckled during the convergence of the Siberian and Tarim cratons following the closure of the Ob-Zaisan Ocean (in the north) and the South Tianshan Ocean (in the south) (e.g. Abrajevitch et al., 2008). This model, however, is not supported by our new data that constrain the closure of the Ob-Zaisan Ocean to the Late Carboniferous. Alternatively, we propose that oroclinal bending may have involved two phases of bending, with the ~110° rotation in the Late Devonian to Early Carboniferous possibly associated with trench retreat. Further tightening may have occurred in response to the convergence of the Siberian and Tarim cratons during the Late

  6. The phenomenon of phase separated in Na2O-B2O3-SiO2, Na2O-SiO2-P2O5 glasses

    International Nuclear Information System (INIS)

    Procyk, B.; Bieniarz, P.; Plichta, E.; Pudelek, B.; Kucinski, G.; Staniewicz-Brudnik, B.

    1997-01-01

    During the thermal treatment, the phenomenon of phase separation has been observed in the some glasses. The glass has became opaque, due to the opalescence of phase separated. Investigations of the phenomenon of phase separation were conducted using the basic systems: Na 2 O-B 2 O 3 -SiO 2 , Na 2 O-SiO 2 -P 2 O 5 and theirs modifications. The occurrence of binodal and spinodal phase decomposition was observed by TEM. The phase separation inhomogeneities have drop-like character and with higher concentration shows a tendency for coalescence. The influence of the chemical composition, temperature and time on the phenomenon of phase separation in the investigated glasses has been defined. (author)

  7. Consideraciones del bioderecho sobre la eutanasia en Colombia

    Directory of Open Access Journals (Sweden)

    José Antonio García Pereáñez

    2017-01-01

    Full Text Available Este artículo aborda de manera reflexiva las incidencias del bioderecho sobre situaciones de eutanasia en Colombia, al interpretar conflictos morales y jurídicos suscitados por las sentencias de la Corte Constitucional C239 de 1997, T970 de 2014 y la Resolución del Ministerio de Salud y Protección Social 1216, de 2015. El propósito fundamental es el análisis de las decisiones judiciales sobre el final de la vida humana. Por lo tanto, se realiza una revisión de la construcción histórica y jurídica del concepto de eutanasia y se propone la discusión sobre su manejo jurídico y su influencia en el colectivo moral. Asimismo, se diserta sobre el concepto de dignidad humana y muerte digna, como precedentes para dirimir los conflictos éticos que la eutanasia suscita. Al final, se analiza el caso de don Ovidio González, quien se convirtió en 2015 en el primer colombiano en recibir la eutanasia de manera legal dentro del sistema de salud.

  8. Impacto de las redes sociales sobre la salud

    OpenAIRE

    Roldán Roldán, Raquel; Aranda Aranda, Federico Manuel; González Castillo, Silvia

    2017-01-01

    Cartel presentado en el 3er Congreso Internacional de Comunicación en Salud (3ICHC), celebrado los días 19 y 20 de octubre de 2017 en la Universidad Carlos III de Madrid. El objetivo de este trabajo es analizar si existe una influencia de las redes sociales sobre la población en temas relacionados con su salud.

  9. Sobre-educación en el mercado laboral colombiano

    Directory of Open Access Journals (Sweden)

    Jhon James Mora

    2008-12-01

    Full Text Available Este artículo analiza la sobre-educación en Colombia con datos de individuos y empresas compilados por el Servicio Nacional de Aprendizaje de Colombia en 2006, encuentra que la probabilidad de estar sobre-educado es del 14% y que depende de la movilidad entre áreas de desempeño, la experiencia, el género, el tamaño de la empresa y el nivel de educación. Los trabajadores sobre-educados ganan un 2% menos que los trabajadores correctamente educados, conforme al patrón internacional. Los resultados también muestran que la probabilidad de que los profesionales permanezcan en la misma área de desempeño aumenta con la experiencia, que cuanto mayor es la sobre-educación menor es la probabilidad de permanecer en dicha área y que los trabajadores con postgrado tienen menor probabilidad de permanecer en su área de desempeño.

  10. REFLETINDO SOBRE AS ESPECIFICIDADES DA GEOGRAFIA NA CRISE DA MODERNIDADE

    Directory of Open Access Journals (Sweden)

    Patrício A. S. Carneiro Carneiro

    2010-08-01

    Full Text Available O presente artigo discute a evolução da ciência moderna, bem como a crise desse paradigma dominante e seus efeitos sobre a geografia. Destaca ainda a necessidade da construção de um novo pensamento científico para além das fronteiras disciplinares e do método absoluto.

  11. 1er. Taller internacional sobre oso hormiguero gigante (Myrmecophaga tridactyla)

    OpenAIRE

    M.V. Guillermo Pérez Jimeno

    2008-01-01

    ResumenLos pasados días 2 y 3 de noviembre se llevó a cabo el 1er. Taller internacional sobre oso hormiguero gigante (Myrmecophaga tridactyla), en instalaciones del Zoológico de Florencio Varela. Participaron activamente representantes de Brasil, Colombia, Holanda, Alemania y Argentina.

  12. Nota sobre el cambio de variable en las integrales definidas

    OpenAIRE

    Soriano, Luis Ignacio

    2012-01-01

    En los textos más frecuentemente empleados por nuestras alumnos de las Facultades técnicas no se hacen indicaciones de ninguna clase sobre las precauciones que es necesaria tomar en el caso de cambio de variable en las integrales definidas; El siguiente ejemplo hará ver la necesidad de ser cuidadosos

  13. Rutas de glicosilación en Candida albicans: circuitos reguladores y efectos sobre virulencia

    OpenAIRE

    Domínguez Cantero, María del Pilar

    2011-01-01

    [ES]Esta tesis trata sobre las rutas de glicosilación en Candida albicans: circuitos reguladores y efectos sobre virulencia. [EN]This thesis is about glycosylation pathways in Candida albicans: regulatory circuits and effects on virulence.

  14. Tiempo de feminismo. Sobre feminismo, proyecto ilustrado y postmodernidad, de Celia Amorós [Ressenya

    OpenAIRE

    Campillo, Neus

    1998-01-01

    Se trata de una reseña sobre el libro Amorós, C., Tiemp de feminismo. Sobre feminismo, proyecto ilustrado y postmodernidad. Madrid, Cátedra, Universitat de Valencia, Instituto de la Mujer, 1997, 463 pp.

  15. Nové poznatky ze studia mineralogie, fluidních inkluzí a izotopů síry v rudách skarnového ložiska v Obřím dole

    Czech Academy of Sciences Publication Activity Database

    Pašava, J.; Veselovský, F.; Dobeš, P.; Haluzová, Eva; Ackerman, Lukáš; Tásler, R.

    2016-01-01

    Roč. 49, č. 1 (2016), s. 47-52 ISSN 0514-8057 R&D Projects: GA ČR GA13-15390S Institutional support: RVO:67985831 Keywords : Obří důl skarn-type deposit * mineralogy * fluid inclusions * sulfur isotopes Subject RIV: DB - Geology ; Mineralogy

  16. Hölderlin: sobre la religión

    Directory of Open Access Journals (Sweden)

    Andrés Alfredo Castrillón Castrillón

    2014-06-01

    Full Text Available El artículo se propone dilucidar la noción de religión que tiene Friedrich Hölderlin en el ensayo “Sobre la religión”, el cual traza un pensamiento tan o más complejo de la relación hombre - dios, y hombre - comunidad, que los de filósofos como Kant o Hegel en sus reflexiones sobre Dios y la religión. Destacar por medio del análisis del ensayo cómo comprende Hölderlin la religión y cómo la vincula con la vida de los hombres en su contexto es la tarea fundamental del escrito, para concluir con las propuestas poéticas de la fundación de religiones o sus manifestaciones a través del mito.

  17. Pregnancias. Sobre cuatro lavis de Colette Deblé

    Directory of Open Access Journals (Sweden)

    Jacques Derrida

    2013-07-01

    Full Text Available ¿Cómo citar la representación del cuerpo femenino en la Historia del Arte occidental dejándose impregnar por los patrones y modelos pictóricos masculinos pero imprimiendo, a su vez, otras huellas, las de otro cuerpo? Esta pregunta atraviesa el texto del filósofo Jacques Derrida sobre las aguadas (lavis de la pintora francesa Colette Deblé, dando lugar a una reflexión sobre el engendramiento, el parto y la cita pictórica. En el trabajo de Colette Deblé, el legado de la Historia del Arte y su mitología engendrarán una serie infinita de aguadas donde el agua no pretende “lavar” la tradición (deshacerse de ella, acabar con ella sino inundarla, mojarla, empaparla con nuevas aguas para, escurriéndola, hacerla resonar nuevamente.

  18. Conceitos de mulheres sobre sua menstruação

    Directory of Open Access Journals (Sweden)

    Márcia Yuri Shinohara

    1994-06-01

    Full Text Available Dando prosseguimento às pesquisas anteriores realizadas pelo Núcleo de Assistência para o Autocuidado da Mulher (NAAM sobre aspectos relativos à menstruação, desenvolvemos um trabalho que estudou os conceitos de 705 mulheres sobre sua menstruação. Foram utilizadas informações do banco de dados do NAAM, obtidos na aplicação do Histórico de Saúde da Mulher no Município de Vargem Grande Paulista. O conceito mais relatado pelas mulheres foi o Normal. Isto talvez explique os dados obtidos em trabalhos anteriores, onde muitas mulheres nada fazem para aliviar os sintomas dolorosos da menstruação. O acesso a estes conceitos próprios é importante para elaborar uma assistência de enfermagem de qualidade respeitando as crenças e valores dentro da cultura das mulheres.

  19. Últimos trabajos sobre ladrillos huecos y perforados

    Directory of Open Access Journals (Sweden)

    Editorial, Equipo

    1958-10-01

    Full Text Available Not availableEn la Building Research Station se están llevando a cabo, cada día con resultados positivos más alentadores, investigaciones sobre nuevos tipos de ladrillos huecos y perforados. Es de esperar que, en breve, todos estos estudios den lugar a la aparición de unas normas para su empleo en escala industrial y, precisamente ahora, es, en Inglaterra, el momento oportuno, puesto que, actualmente, está celebrando reuniones la Sociedad Cerámica Británica. Lo que se publica en este artículo es un anticipo sobre las tendencias actuales dentro da este campo.

  20. MITOS Y LEYENDAS SOBRE LOS JUEGOS DE ROL

    Directory of Open Access Journals (Sweden)

    Rocío Tizón

    2010-11-01

    Full Text Available Los juegos de rol aparecen en la década de los años 70 en Estados Unidos, creados por Gary Gigax y Dave Arneson, padres del ya famoso Dragones & Mazmorras. No obstante, fueron pocos los años de tranquilidad, ya que en su país natal se le consideró culpable de promover el suicidio de varios adolescentes que habían sido jugadores de Dragones & Mazmorras. Los engaños de la información y los prejuicios de las noticias sobre estos juegos de rol provocaron que varias personas se interesaran por este fenómeno, analizando dichos mitos y comprobando la verdad de estos rumores. Uno de estos estudiosos fue William Watson, creador de la página web The Inquirer, en la que se dedica a desmontar estos y otros tópicos sobre juegos de rol.

  1. Consenso Cultural sobre el Intento de Suicidio en Adolescentes

    Directory of Open Access Journals (Sweden)

    Javier Eduardo García de Alba García

    2011-01-01

    Full Text Available Este estudio buscó identificar la estructura semántica del dominio cultural, el promedio de conocimiento y el grado de consenso cultural manifestado por los adolescentes sobre el intento de suicidio. Fue un estudio cualitativo de listas libres, con un muestreo propositivo no aleatorizado de 27 adolescentes entre 13 y 18 años. Los resultados evidenciaron un solo modelo semántico. En lo estructural se identificó el problema familiar como una causa importante del intento suicida; las categorías depresión y tristeza se consideraron como signos y síntomas previos a esta tentativa y no como causas. Como estrategias de prevención, se consideró recibir información mediante pláticas o establecer conversaciones sobre los problemas. Este modelo permite proponer estrategias de prevención que privilegien el núcleo familiar.

  2. Planteamientos sobre la pobreza: una aproximación conceptual

    Directory of Open Access Journals (Sweden)

    Bertha Lucía Martínez Bernal

    2015-07-01

    Full Text Available En el presente artículo se presentan varias definiciones o conceptos para la comprensión, medición y el análisis de la pobreza. Para ello se retoma la producción escrita de diferentes estudiosos e investigadores que han hecho aportes valiosos sobre el tema. Al lado de estos conceptos se analizan los diferentes enfoques que se utilizan para aproximarse al estudio de la pobreza, aunque estas no son teorías ni explicaciones de sus causas, sino perspectivas sobre pobreza que denotan dichos enfoques. Así mismo se desarrolla una revisión de las metodologías más utilizadas en los procesos de identificación y agregación. Finalmente se interpretan las políticas públicas en los sectores sociales.

  3. Concepções sobre criminalidade e modelos de policiamento

    Directory of Open Access Journals (Sweden)

    Marco Antônio de Azevedo

    Full Text Available Podem-se conceber duas perspectivas teóricas básicas para explicar a criminalidade: a culturalista e a racionalista. Da primeira derivam políticas públicas destinadas a reduzir a criminalidade através de uma atuação sobre a desorganização social. Na segunda privilegia-se uma estratégia segundo a qual o principal papel do Estado é dissuadir o criminoso da prática delituosa. Este trabalho revisa a literatura, evidenciando mitos sobre o crime e a atividade policial. São discutidos dois modelos de policiamento: um mais tradicional e reativo e outro mais preventivo, procurando-se mostrar que o racionalismo dá maior suporte teórico a políticas de segurança pública que valorizam a promoção da cidadania.

  4. O pensamento freudiano sobre a intolerância

    OpenAIRE

    Fuks,Betty Bernardo

    2007-01-01

    A partir do conceito psicanalítico de "narcisismo das pequenas diferenças", o artigo tem como objetivos pensar o modo como Freud foi tecendo um pensamento sobre a intolerância e discutir as contribuições da psicanálise à história das teorias sobre a tolerância. A autora perscruta o fenômeno de intolerância à diferença do outro à luz dos trabalhos de Freud que envolvem e atestam sua sensibilidade para com a intolerância racista que atingiu o tempo em que viveu. Desde este trajeto, propõe algum...

  5. Bombeiros: um olhar sobre a qualidade de vida no trabalho

    Directory of Open Access Journals (Sweden)

    Janine Kieling Monteiro

    Full Text Available Este trabalho apresenta uma intervenção no corpo de bombeiros (São Leopoldo - RS realizada pelo NEPT (Núcleo de Excelência em Psicologia do Trabalho. Utilizamos um diagnóstico com sessenta e três entrevistas semi-estruturadas sobre o trabalho e funcionamento da corporação. Partindo da análise deste, propusemos palestras sobre estresse e qualidade de vida no trabalho (QVT. Foram levantados questionamentos acerca do mito do herói e do amor pela profissão bombeiro, que deixa em segundo plano seus problemas. Destacou-se o estresse no trabalho por situações traumáticas, como risco de vida eminente e mortes nos salvamentos. Entendemos que as intervenções contribuíram como espaço de escuta que propiciou reflexões a respeito da QVT.

  6. Sobre inundaciones y anegamientos / Reflections on floods and flooding

    Directory of Open Access Journals (Sweden)

    Ferrando A., Francisco J.

    2006-11-01

    Full Text Available Respecto a anegamientos e inundaciones, el autor realiza algunas precisiones conceptuales que afectan la gestión de acciones preventivas, la planificación y el ordenamiento territorial; además se ofrece una sistematización del quehacer sobre las inundaciones./ The author punctualizes the concepts regarding preventive actions and territorial planning. Also the article includes a systematized list of actions related to flood management.

  7. Para saber más sobre la violencia escolar

    Directory of Open Access Journals (Sweden)

    María Rosario Fernández Domínguez

    2001-01-01

    Full Text Available En este documento se recoge una parte importante de la producción bibliográfica sobre la violen-cia escolar y otros temas colaterales, publicada en lengua castellana a partir de 1990. Se deja constanciatambién de la legislación española más reciente para facilitar la convivencia en los centros de enseñanza.

  8. Nuevos discursos sobre las ciudades, los municipios y las mujeres

    Directory of Open Access Journals (Sweden)

    Ana María Goetschel

    2009-01-01

    Full Text Available Escritora y activista feminista. Estudió Literatura y Periodismo en la Pontificia Universidad Católica del Perú y se gradúo de Magíster en Política Social por la Universidad Nacional Mayor de San Marcos. Por espacio de más de dos décadas se desempeña como profesora en el Diploma de Estudios de Género de la Pontificia Universidad Católica del Perú y como consultora de proyectos de desarrollo en las áreas de planificación, evaluación institucional y enfoque de género para diversas agencias internacionales de cooperación en Perú y otros países de América Latina. Es Investigadora asociada y miembro del Consejo Directivo del Centro Peruano de Estudios Sociales (CEPES. Maruja Barrig acredita un vasto trabajo de investigación sobre empleo femenino, desarrollo local y organizaciones de mujeres. En una reciente conferencia “Nuevos discursos sobre las ciudades, los municipios y las mujeres” , esta investigadora peruana hizo un balance sobre las formas en que el género ha sido incorporado en las prácticas de desarrollo y las consecuencias que conlleva este tipo de intervención para el avance de la agenda del feminismo crítico. Sobre este y otros temas relacionados con su trayectoria intelectual y la acción del movimiento de mujeres en el contexto político actual de las sociedades latinoamericanas, dialogamos con Maruja Barrig.

  9. Reflexiones sobre interpretaciones recientes de la violencia en Colombia

    Directory of Open Access Journals (Sweden)

    Pedro Valenzuela

    2002-01-01

    Full Text Available Estudios recientes han negado la relación de causalidad entre las condiciones objetivas y la violencia en Colombia. Este artículo critica la forma como se ha llegado a estas conclusiones y discute algunas hipótesis que vinculan la cultura y las causas objetivas con la violencia. Concluye con una discusión sobre la interpretación de la relación entre causas estructurales y el conflicto armado interno.

  10. Propiedades beneficiosas de los terpenos iridoides sobre la salud

    OpenAIRE

    López-Carreras, Noemi; Miguel, Marta; Aleixandre, Amaya

    2012-01-01

    [ES]: Algunos componentes de los alimentos presentan actividad biológica y pueden producir un efecto beneficioso sobre la salud. Aquellos que provienen de las plantas se conocen con el nombre de fitoquímicos. Muchos de estos compuestos proceden de la condensación del isopreno y presentan la estructura propia de los terpenos. Entre ellos, destacan algunos monoterpenos bicíclicos derivados del geraniol, que se denominan iridoides. Los iridoides pueden encontrarse como estructuras abiertas...

  11. Significaciones imaginarias sobre el espacio público

    OpenAIRE

    Bilyk, Pablo Andrés

    2012-01-01

    El presente escrito se propone profundizar y poner en discusión una serie de reflexiones en torno de las significaciones imaginarias, el rol del investigador en su abordaje y los modos en que este concepto nos permite aproximarnos a los sentidos construidos sobre el espacio público. This article aims to discuss some ideas over imaginary significations, researcher's role in their analysis and the ways in which this concept allows us to reach public space built senses. Facultad de Periodi...

  12. Two Twin Judgements of Cienfuegos Dos juicios gemelos sobre Cienfuegos

    Directory of Open Access Journals (Sweden)

    René ANDIOC

    2011-01-01

    Full Text Available Manuel eduardo de Gorostiza, in London after the constitutional triennium, signed four articles about Spanish theatre in The New Monthly Magazine using just the letter «G». At the end of that same year, 1824, an author signing with an «M», in all likelihood Prosper Mérimée, published a set of articles in Le Globe in Paris regarding the same topic. these were literal translations of those written by Gorostiza about cienfuegos, but his authorship is not mentioned.Manuel eduardo de Gorostiza, en Londres después del trienio constitucional, firmó «G» cuatro artículos sobre teatro español moderno en The New Monthly Magazine. Al final del mismo año de 1824, un tal «M», con toda probabilidad el joven Próspero Mérimée, publicó en el periódico Le Globe, de París, otros tantos sobre el propio tema, traduciendo literalmente en particular, sin mención de fuente, lo escrito por Gorostiza sobre cienfuegos.

  13. Sobre nomes e coisas: Arnaldo Antunes em sala de aula

    Directory of Open Access Journals (Sweden)

    Érica Dias Gomes

    2016-12-01

    Full Text Available A presente pesquisa teve como objetivo investigar sobre a compreensão de alunos de um curso de formação de docentes sobre as obras audiovisuais “Nome” e “Carnaval” de Arnaldo Antunes, pensando na forma com que percebem seu cotidiano e a sociedade atual por meio da interpretação. O questionamento que se faz é como, a partir da reflexão sobre as obras do artista, desenvolver um trabalho de sensibilização, investigação e criação em sala de aula. A pesquisa participante apresenta uma proposta pedagógica realizada com uma turma de estudantes do curso de formação de docentes do Colégio Estadual Visconde de Guarapuava, buscando desenvolver assim a expressividade e a formulação de ideias de forma conjunta, por meio do desenvolvimento de um processo criativo. Foram analisados os resultados das propostas realizadas em sala de aula, além dos registros em diário de campo. Por meio da pesquisa, percebeu-se a importância dos trabalhos que envolvam fruição, reflexão e produção como forma de apropriação dos conteúdos.

  14. Orden de no reanimar, consideraciones sobre este problema

    Directory of Open Access Journals (Sweden)

    Dr. G. Luis Cereceda

    2011-05-01

    Se analizan los principales problemas, comenzando por las dificultades según los diferentes escenarios (servicio de urgencia, pabellón de maternidad, sala de hospitalizados, unidad de intensivo, pabellones quirúrgicos; se analiza la incertidumbre sobre el pronóstico de cada pacientes y sobre quién(es deben tomar las decisiones sobre el fin de la vida. Idealmente debe ser el paciente autónomo quien tome la decisión, pero en otros casos se requieren alternativas, una de ellas es la Orden Unilateral. Otros problemas son la Validez de las órdenes de no-RCP en los diferentes tiempos evolutivos, el problema de la Futilidad y la Validez de las “Directivas Anticipadas”, en este grupo resalta el enfoque POLST (Physician’s Order for Life Sustaining Treatment como más comprehensivo; como complemento ha surgido también el concepto AND (Allow Natural Death, que podría estar destinado a remplazar la orden de no-RCP (DNR.

  15. Sobre el Contenido de los Marcos Conceptuales Contables

    Directory of Open Access Journals (Sweden)

    Leila Di Russo de Hauque

    2007-12-01

    Full Text Available El presente trabajo tiene como objetivo el análisis de los distintos marcos conceptuales vigentes en diferentes sistemas normativos contables. Paralelamente a las revisiones empíricas que dicho trabajo determina, incluye reflexiones a priori sobre el contenido de dichos marcos conceptuales. El trabajo discurre inicialmente sobre el problema de la naturaleza normativa o doctrinaria de sus contenidos tradicionales sin inclinarse definitivamente por una u otra vertiente. Respecto de los elementos que se incluirán en ellos, se justifica la inclusión de las listas de objetivos y requisitos de la información contable para definir el alcance del concepto de informe de uso externo. Además se define a favor de la inclusión, conjuntamente con las respuestas a las pregunas básicas sobre la labor contable, de contenidos ligados al proceso de obtención y de la exposición de la información contable de uso externo.

  16. Uma Reflexão sobre Autoria Acadêmica

    Directory of Open Access Journals (Sweden)

    Francisco José da Costa

    2017-06-01

    Full Text Available Este estudo tem como objetivo apresentar elementos para um debate sobre a ética das práticas de autoria no campo científico brasileiro. Os autores utilizam exemplos ilustrativos para explorar as práticas de pseudoautoria, estabelecendo relações entre essas práticas, as coerções oriundas do campo acadêmico e o habitus dos agentes sociais. Foi elaborada uma definição preliminar do que seja autoria a fim de possibilitar a discussão sobre dois problemas centrais, que são: a lógica de “colocar o nome” e o plágio. Uma das principais contribuições deste trabalho repousa na reflexão orientada para a construção de uma prática aperfeiçoada de autoria, possibilitando a crítica e a autocrítica dos agentes do meio acadêmico sobre algumas práticas problemáticas de autoria.

  17. Hegel sobre Tácito y la libertad teutona

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    Valerio Rocco Lozano

    2015-09-01

    Full Text Available Una investigación sobre la presencia (así como sobre la ausencia de Tácito en Hegel es crucial para entender la posición política y filosófica de este pensador, especialmente en la época de Jena. Tras algunas consideraciones sobre el conocimiento hegeliano de la historia y la cultura romanas, se abordará un análisis de su noción de "libertad teutona": Hegel se opone tanto a la neo-romanidad de los revolucionarios franceses como al esencialismo teutómano de los conservadores alemanes (derivado fundamentalmente de un uso fuertemente ideológico de la "Germania" de Tácito, así como a las caducas instituciones imperiales. Esta doble oposición sitúa a Hegel en medio de dos corrientes políticas (e incluso de dos ejércitos en guerra y se lleva a cabo desde una actitud que puede denominarse como “mediación sin nostalgia”

  18. La red sobre trabajo infantil peligroso (Red Tip

    Directory of Open Access Journals (Sweden)

    Walter Varillas

    2003-01-01

    Full Text Available En el mundo, aproximadamente 351.7 millones de niños entre 5 y 17 años realizaban algún tipo de actividad económica, de ellos 170.5 millones (48.5% realizaban algún tipo de trabajo considerado peligroso. Un alto porcentaje se encuentra en la agricultura, otros en minas, manufacturas, ladrilleras, predominantemente en la economía informal. El Convenio 138 (cobre la edad mínima de admisión en el empleo de la OIT y el Convenio 182 (sobre las peores formas de trabajo infantil, definen como trabajo infantil peligroso el que puede afectar la salud, seguridad y moralidad de los menores. Estudios específicos sobre los menores muestran su susceptibilidad particular frente a los riesgos laborales, aumentando la peligrosidad para su normal desarrollo y crecimiento: "los niños no son adultos pequeños". Los profesionales de la seguridad y salud en el trabajo pueden colaborar con los profesionales y las organizaciones especializadas en el trabajo infantil, en la definición y caracterización de lo que significa el trabajo infantil peligroso. Para ello se ha conformado la Red sobre Trabajo Infantil Peligroso (Red TIP, con la finalidad de articular estos dos espacios, orientados a eliminar el trabajo infantil peligroso y rescatar al menor y devolverle la oportunidad de sonreír ahora y en el futuro.

  19. Effect of Mixed Glass Former on Ionic Conductivity of Silver Boro Tungstate glass system x[0.75AgI:0.25AgCl]: (1-x) [Ag2O-{B2O3:WO3}

    Science.gov (United States)

    Dehariya, Harsha; Kumar, R.; Polu, A. R.

    2012-05-01

    The idea to explore new 'Superionic Electrolytes', "Fast ionic conductors" is due to their tremendous potential applications in solid state electrochemical devices viz. solid state batteries, fuel cells, sensors, super capacitors. Superionic glasses have attracted great deal of attention due to their several advantageous over their crystalline counterparts such as high ionic conductivity, easy preparation, wide selection of compositions, isotropic properties and high stability etc [4-7]. Large numbers of silver ion based glasses have been reported in the literature for the glassy system of AgI:Ag2O: MxOy (MxOy = B2O3, SiO2, P2O5, GeO2, V2O5, As2O5, CrO3, SeO2, MoO3 & TeO3 etc many of them shows high silver ion conductivity [8]. Ion transport behavior of Silver Boro Tungstate glass system x[0.75AgI:0.25AgCl]: (1-x) [Ag2O{B2O3:WO3}], where 0 <= x <= 1 in molar wt% prepared by melt quench technique were reported. The new host [0.75AgI:0.25AgCl] was used as a better alternate in place of conventional host salt AgI. Conductivity measurement were carried out on this glass system as a function of frequency from 50 Hz to 5 MHz, over a temperature range of 27°C to 200°C, for different compositions by Impedance spectroscopy. The composition 0.7[0.75AgI:0.25AgCl]: 0.3[Ag2O{B2O3:WO3}] shows the highest conductivity of the order of σrt ~ 2.76 × 10-2 S/cm, referred to as the Optimum Conducting Composition (OCC). The enhancement in the conductivity has been obtained by mixed former effect. XRD result shows that the system is completely amorphous. Temperature dependence of conductivity of all compositions were studied & reported. Activation energies (Ea) were also evaluated from the slope of .Log(σ) vs 1000/T, Arrhenius plots.

  20. Effect of Mixed Glass Former on Ionic Conductivity of Silver Boron Tungstate glass system x[0.75AgI:0.25AgCl]: (1-x) [Ag2O-(B2O3:WO3)

    International Nuclear Information System (INIS)

    Dehariya, Harsha; Kumar, R; Polu, A R

    2012-01-01

    The idea to explore new 'Superionic Electrolytes', 'Fast ionic conductors' is due to their tremendous potential applications in solid state electrochemical devices viz. solid state batteries, fuel cells, sensors, super capacitors. Superionic glasses have attracted great deal of attention due to their several advantageous over their crystalline counterparts such as high ionic conductivity, easy preparation, wide selection of compositions, isotropic properties and high stability etc [4-7]. Large numbers of silver ion based glasses have been reported in the literature for the glassy system of AgI:Ag2O: MxOy (MxOy = B2O3, SiO2, P2O5, GeO2, V2O5, As2O5, CrO3, SeO2, MoO3 and TeO3 etc many of them shows high silver ion conductivity [8]. Ion transport behavior of Silver Boro Tungstate glass system x[0.75AgI:0.25AgCl]: (1-x) [Ag2O(B2O3:WO3)], where 0 ≤ x ≤ 1 in molar wt% prepared by melt quench technique were reported. The new host [0.75AgI:0.25AgCl] was used as a better alternate in place of conventional host salt AgI. Conductivity measurement were carried out on this glass system as a function of frequency from 50 Hz to 5 MHz, over a temperature range of 27 C to 200 C, for different compositions by Impedance spectroscopy. The composition 0.7[0.75AgI:0.25AgCl]: 0.3[Ag2O(B2O3:WO3)] shows the highest conductivity of the order of σrt ∼ 2.76x10-2 S/cm, referred to as the Optimum Conducting Composition (OCC). The enhancement in the conductivity has been obtained by mixed former effect. XRD result shows that the system is completely amorphous. Temperature dependence of conductivity of all compositions were studied and reported. Activation energies (Ea) were also evaluated from the slope of .Log(σ) vs 1000/T, Arrhenius plots.

  1. Hardness properties and microscopic investigation of crack- crystal interaction in SiO(2)-MgO-Al(2)O(3)-K(2)O-B(2)O(3)-F glass ceramic system.

    Science.gov (United States)

    Roy, Shibayan; Basu, Bikramjit

    2010-01-01

    In view of the potential engineering applications requiring machinability and wear resistance, the present work focuses to evaluate hardness property and to understand the damage behavior of some selected glass-ceramics having different crystal morphologies with SiO(2)-MgO-Al(2)O(3)-K(2)O-B(2)O(3)-F composition, using static micro-indentation tests as well as dynamic scratch tests, respectively. Vickers hardness of up to 5.5 GPa has been measured in glass-ceramics containing plate like mica crystals. Scratch tests at a high load of 50 Nin artificial saliva were carried out in order to simulate the crack-microstructure interaction during real-time abrasion wear and machining operation. The experimental observations indicate that the novel "spherulitic-dendritic shaped "crystals, similar to the plate like crystals, have the potential to hinder the scratching induced crack propagation. In particular, such potential of the 'spherulitic-dendritic' crystals become more effective due to the larger interfacial area with the glass matrix as well as the dendritic structure of each mica plate, which helps in crack deflection and crack blunting, to a larger extent.While modest damage tolerant behavior is observed in case of 'spherulitic-dendritic' crystal containing material, severe brittle fracture of plate like crystals were noted, when both were scratched at 50 N load.

  2. QUESTÕES SOBRE A PENA DE MORTE

    Directory of Open Access Journals (Sweden)

    SOUSA, L.N.

    2015-12-01

    Full Text Available Pelo menos, desde o Código de Hamurabi as punições para atos desviantes tem sido um foco de reflexão. Este trabalho encerra essa reflexão acerca de aspectos em torno do tema pena de morte. Além de feito político contra o crime, também seria um ato com fins vingativos, fundamentado na violação da dignidade humana, o que justifica a necessidade de haver uma rigorosa análise sobre tal questão, visando os argumentos lógicos, baseados na realidade social brasileira. Alguns estudos demonstram que a percepção da classe menos favorecida é que já existe, de certa forma, uma pena de morte informal no Brasil, praticada pela polícia ou grupos de extermínio. No entanto, diversos setores defendem a pena de morte em nome dos direitos humanos. O debate sobre o referido tema não deve limitar-se às questões relacionadas ao desenvolvimento moral individual, antes deve incluir também a análise de fatores históricos, culturais, econômicos, políticos e ideológicos. Este estudo tem como objetivo coletar dados bibliográficos, bem como dados sobre as opiniões que as pessoas em Campos dos Goytacazes têm sobre a pena de morte. A pesquisa feita é de caráter exploratório. Utilizaram-se as metodologias pertinentes a uma pesquisa bibliográfica. Foi realizada com moradores da cidade de Campos dos Goytacazes/RJ, especificamente com 40 jovens e adultos, de gênero masculino e feminino, com idades entre 18 e 48 anos, sendo a maioria mulheres. A coleta de dados foi feita através de questionários fechados, do tipo likert. Cerca de 48% da amostra concorda com a sentença pena de morte. As respostas quanto a não ter opinião formada sobre o assunto foram minoria, somando 20% ao todo, restando 32% de sujeitos que declararam ser contrários. Metade dos sujeitos não concordou que a sentença seria aplicada corretamente no Brasil. A minoria concordou que a lei teria uma aplicabilidade positiva no país. Aproximadamente 43% dos sujeitos pesquisados

  3. Parte de la Naturaleza: sobre el cuerpo como potencia compositiva

    Directory of Open Access Journals (Sweden)

    Juliana Merçon

    2012-11-01

    Full Text Available http://dx.doi.org/10.5007/2175-795X.2012v30n2p473 En medio de la constelación de mitos que han contribuido a la actual crisis socioecológica,se encuentra la creencia de que somos individuos sustanciales, atomizadoso separados del entorno al cual intentamos ‘dominar’. La ignorancia con respecto anuestra interdependencia ontológica está en la base de muchas de nuestras posturas(auto destructivas y ha sido reforzada por diversos sistemas teóricos a lo largo de lahistoria occidental. Al margen de dualismos platónicos, de transcendencias judaicocristianasy del cogito cartesiano, la filosofía de Benedictus de Spinoza (1632-1677nos invita a repensar los fundamentos de la realidad compleja en la cual estamosinmersos. Mi propósito en este artículo es tejer relaciones productivas entre algunasdimensiones de su filosofía, el pensamiento ambiental y la educación. El punto departida será la concepción spinozista de cuerpo. Este será definido como potencia quese expresa a la vez como productividad (fuerza causal y sensibilidad (fuerza receptiva.El carácter esencialmente relacional y afectivo del cuerpo humano nos permitirápensarlo también como potencia compositiva. Desconstruyendo la dicotomíaentre Naturaleza y Cultura, propondré que reflexionemos sobre las composicioneshumano-tecnológicas con respecto a sus efectos sobre nuestra potencia de pensar yactuar. En conclusión, presentaré algunos comentarios sobre el rol de la educacióncomo espacio relacional, en el cual se pueden integrar de forma potenciadora lasdimensiones epistémica, ética, política y ambiental de nuestra existencia como partesinterdependientes de la Naturaleza.

  4. Conocimientos de los adolescentes sobre aspectos de la sexualidad

    Directory of Open Access Journals (Sweden)

    Ileana García Imia

    2002-12-01

    Full Text Available Se realizó un estudio descriptivo retrospectivo, de corte transversal, en el área del Policlínico Docente "Wilfredo Pérez Pérez" del municipio San Miguel del Padrón, de Ciudad de La Habana, con el fin de explorar los conocimientos sobre algunos aspectos de la sexualidad, en un grupo de 100 adolescentes en edades entre 10 y 19 años y de uno y otro sexos, en el año 2001. Se apreció un elevado tanto por ciento de jóvenes que tenían conocimientos sobre la anatomía del aparato genital, la mejor edad para tener hijos y la anticoncepción. En general, no tenían conocimientos de todas las enfermedades de transmisión sexual, no así el método más eficaz para evitarlas. El grupo de edad de mayor relevancia lo constituyó el de 10 a 13 años por sus escasos conocimientos sobre sexualidad.A retrospective, descriptive and crosswise study was made in the health areas of "Wilfredo Pérez Pérez" Teaching Polyclinics in San Miguel del Padrón municipality, Havana City province, with the objective of exploring what a group of 100 adolescents aged 10-19 years of both sexes knows about sexuality in the year 2001. A high percentage of them had knowledge about anatomy of the genital system, the most suitable age for having children and contraception. In general, they did not know all the sexually-transmitted diseases but they did know the most efficient method to prevent them. The most relevant age group was 10-13 years old because of their poor knowledge about sexuality.

  5. Estado del arte del conocimiento sobre perifiton en Colombia

    Directory of Open Access Journals (Sweden)

    Yimmy Montoya Moreno

    2013-12-01

    Full Text Available El perifiton es un componente de las comunidades bióticas acuáticas, su estudio es importante tanto desde la perspectiva ecológica, para comprender el funcionamiento de los ecosistemas acuáticos, como desde el punto de vista ambiental, pues su composición y estructura pueden servir como indicadores de la calidad del agua y de procesos que como la contaminación puedan estar afectando a los ecosistemas. La investigación sobre el perifiton es compleja; la definición misma de perifiton aún genera controversias. Sumado a esto, la variedad de metodologías para su estudio integral, la diversidad de arquitecturas de la matriz perifítica, la gran diversidad de ecosistemas y la ausencia de escuelas taxonómicas en el país, contribuyen a que sean pocos los trabajos que se publican sobre el tema, lo que incrementa el valor e importancia de los estudios reseñados en esta revisión. El objetivo de este artículo es dar a conocer el estado del arte en la investigación sobre el perifiton en Colombia, mediante el análisis de diferentes líneas de investigación que se han desarrollado y su grado de avance. Con este fin, se examinaron 84 trabajos a los que los autores tuvieron acceso. La mayoría de investigaciones consultadas en este trabajo (90%, corresponden al estudio de ficoperifiton, el 10% restante incluyó ambos componentes del perifiton y se encontró una dedicada exclusivamente al zooperifiton. Sólo el 10,5% de las investigaciones (8 trabajos se han dedicado al estudio taxonómico detallado, el resto de publicaciones se orientan al estudio de la estructura y dinámica de la comunidad perifítica.

  6. EL IMPUESTO SOBRE BEBIDAS AZUCARADAS EN ESPAÑA

    Directory of Open Access Journals (Sweden)

    Vicente Ortún

    2016-01-01

    Full Text Available Este artículo aporta una revisión crítica acerca de los retos a los que se enfrentan los impuestos sobre las bebidas azucaradas como instrumento de políticas de salud, para revertir la tendencia epidémica de la obesidad. Se valoran las experiencias de los países más significados, en particular México, y se reflexiona sobre el contrapeso que ejerce la industria a las políticas antiobesidad y el poder de los lobbies. Esas políticas impositivas en pro de la salud pública han de sobreponerse a la enorme fuerza de la industria, que es ejercida en varios niveles –ciencia e investigación, reputación de marca, influencia en reguladores–. Se sugiere que un impuesto específico sobre bebidas azucaradas tiene bastante potencial para reducir enfermedades no transmisibles y riesgos –diabetes mellitus, hipertrigliceridemia, lipoproteínas de baja densidad, hipetensión diastólica–, a través de la reducción del consumo, al ser alta la elasticidad del precio de estas bebidas. Además, los efectos incluso se amplifican a medio plazo, una vez establecidos nuevos hábitos de consumo más saludable. Los impuestos podrían fomentar la innovación empresarial sin infligir costes de pérdida de empleos y contribuirían a reducir el gradiente social de la obesidad.

  7. Dos hipótesis sobre el presidencialismo autoritario

    Directory of Open Access Journals (Sweden)

    Soledad Loaeza

    2013-01-01

    Full Text Available El presidencialismo autoritario mexicano ha sido objeto de muchas reflexiones y opiniones. No obstante, se ha impuesto un paradigma presidencialista que privilegia la perspectiva personalizada e idiosincrática del ejercicio del poder, con un importante componente cultu- ralista. Aquí se propone, por una parte, una perspectiva histórica que contextualiza las accio- nes presidenciales en el período 1944-1970; por la otra, se parte de dos presupuestos generales. Uno, sostiene que los presidentes mexicanos actuaban bajo importantes restricciones y según los ritmos de un proceso que avanzó en episodios, más que en forma lineal o acumulativa; el otro destaca la limitación geopolítica que se deriva de la vecindad con Estados Unidos que incidió sobre las acciones presidenciales, pero también sobre el desarrollo institucional del país. La evolución del presidencialismo autoritario lleva la huella de esta influencia. Este artículo introduce elementos para la discusión de las hipótesis. La primera parte hace una revisión crítica del paradigma presidencialista; la segunda expone las restricciones que se derivaban de la vecindad con Estados Unidos. La tercera y última está dedicada a la descripción del tipo de episodios que Pueden servir para ilustrar la evolución del presidencialismo autoritario. Las dos hipótesis que aquí se presentan han guiado una investigación más amplia sobre el impacto de la Guerra Fría en México y el desarrollo del presidencialismo.

  8. Propuesta de programa educativo sobre enfermedades del cuello uterino

    Directory of Open Access Journals (Sweden)

    Grisel Mariela Mass Basulto

    2011-10-01

    Full Text Available Fundamento: El cáncer ginecológico está entre las más frecuentes causas de muerte en la población femenina. En Cuba, el diagnóstico precoz de tal afección está entre los programas priorizados del Sistema de Salud Pública; pero también es necesario enfatizar en la prevención, que puede lograse, sobre todo, desde la atención primaria de salud, mediante la implementación de programas educativos. Objetivo: Diseñar un programa educativo sobre afecciones del cuello uterino. Métodos: Estudio descriptivo y retrospectivo, en el período comprendido del 1 de enero de 2008 al 1 de enero de 2009. Se analizaron variables como edad, escolaridad, primeras relaciones sexuales, número de partos, número de compañeros sexuales, uso de anticonceptivo, antecedentes de infecciones de transmisión sexual, hábitos tóxicos y nivel de conocimiento. Se aplicó el criterio de expertos para la validación de la propuesta educativa. Resultados: La mayoría de las mujeres tuvieron relaciones sexuales precoces, cuatro o más compañeros sexuales y eran fumadoras, mientras que el total de ellas había presentado alguna vez infecciones vaginales. El nivel de conocimiento que predominó fue regular. Conclusiones: Es evidente que en la población estudiada se concentran varios factores de riesgo para el cáncer de cuello uterino. El Programa Educativo sobre enfermedades del cuello uterino, fue validado mediante criterio de expertos, los cuales coincidieron en que tiene gran actualidad científica, congruencia interna y en que favorece el proceso de preparación de la mujer para evitar ese tipo de enfermedades.

  9. Conocimientos sobre tuberculosis infantil en madres comunitarias de Cartagena, Colombia

    Directory of Open Access Journals (Sweden)

    Jacqueline Hernandez Escolar

    2017-01-01

    Full Text Available Objetivo: Evaluar los conocimientos sobre Tuberculosis (TB Infantil, que tienen las madres comunitarias de Cartagena. Método: Estudio descriptivo realizado con 49 madres comunitarias a las cuales se aplicó una encuesta para evaluar variables sociodemográficas y un cuestionario con 50 preguntas, para medir conocimientos sobre tuberculosis en los niños. Se evaluaron cinco grandes aspectos, (diez preguntas para cada uno así: características de la enfermedad, factores de riesgo, prácticas de prevención, manifestaciones clínicas e identificación de casos, y ruta de atención para los casos sospechosos. Los datos se almacenaron y analizaron en una base de datos del programa SPSSS versión 21, fueron calculadas medidas de frecuencias para las variables categóricas, medidas de tendencia central y desviaciones estándar para variables cuantitativas. Resultado: Del total de participantes, 91,6% (40 desconoce que un individuo con tuberculosis latente puede transmitir la enfermedad; 38,8% (19 no conoce el riesgo que tienen los menores de un año a contagiarse; 22,4% (11 no identifica como factor de riesgo para los niños el contacto estrecho con una persona enferma. Solo el 2% (1 reconoce como signo sugestivo de la enfermedad tuberculosa en los niños la presencia de tos por más de 21 días. Conclusión: Las madres comunitarias de éste estudio tienen poco conocimiento acerca de la TB infantil. Se considera necesario realizar intervenciones educativas a estos actores sociales para que tengan conocimientos amplios sobre este tema.

  10. La UNASUR y el Protocolo sobre Compromiso con la Democracia

    OpenAIRE

    Luchetti, Javier Fernando

    2012-01-01

    En el presente trabajo describiremos brevemente el proceso que llevó a la UNASUR a añadir a su Tratado Constitutivo, el Protocolo Adicional sobre Compromiso con la Democracia, que pretende constituirse en un apéndice importante en la defensa de las instituciones democráticas y el respeto por los derechos humanos en el sur del continente suramericano, más allá que en otras organizaciones regionales también se menciona que la defensa de la democracia es uno de los pilares de dichas organizacion...

  11. Convecção mista sobre cavidade porosa aberta

    OpenAIRE

    Jorge Isaias Llagostera Beltran

    1990-01-01

    Resumo: Este trabalho apresenta um extenso conjunto de resultados de simulação numérica sobre a convecção mista, natural e forçada em uma configuração porosa abert.a. A configuração estudada é formada por uma camada horizontal que apresenta em sua parede inferior uma cavidade de secção transversal retangular. A parede de fundo da cavidade é aquecida e a parede superior da camada horizontal é resfriada ambas isotermicamente o problema em regime permanente é analisado procurando-se estabelec...

  12. Consideraciones sobre la valoración social del agua

    Directory of Open Access Journals (Sweden)

    Robert Hérin

    2003-01-01

    Full Text Available Las características del clima mediterráneo y el intenso aprovechamiento de los recursos hídricos en este ámbito, son los causantes de la excepcional importancia que se atribuye al agua en la cultura y la configuración de los paisajes. En este artículo se realiza un análisis de la evolución que ha seguido, sobre todo en los últimos siglos, el agro mediterráneo, desde las huertas tradicionales y los paisajes de secano a las nuevas formas de aprovechamiento agrícola, desde una perspectiva social.

  13. Aborto y Parlamento: un estudio sobre Brasil, Uruguay y Argentina

    OpenAIRE

    Rocha,Maria Isabel Baltar da; Rostagnol,Susana; Gutiérrez,María Alicia

    2009-01-01

    El presente trabajo desarrolla un estudio comparativo entre Brasil, Argentina y Uruguay sobre las legislaciones y las acciones de diversos actores en relación a la despenalización y/o legalización del aborto. El tema se instala en la agenda pública en los tres países a partir del proceso de democratización iniciado en la década de los 80 produciéndose diversas intervenciones tanto del movimiento de mujeres, como de las corporaciones médicas y otros actores sociales en el transcurso de la déca...

  14. Ensayos sobre la sonrisa de volatilidad en mercados de opciones

    OpenAIRE

    Serna Calvo, Gregorio

    2011-01-01

    La tesis comienza analizando los determinantes de la "sonrisa de volatilidad" en el mercado de opciones sobre el indice IBEX-35,obteniendose evidencia de causalidad lineal en el sentido de Granger de los costes de transacción, representados por el diferencial "bid-ask" relativo, ala forma de la sonrisa. A continuación, se propone un modelo de Black-Scholes ampliando donde la volatilidad depende del precio de ejercicio y del diferencial "bid-ask" relativo, obteniendose que dicho modelo no mejo...

  15. Antioxidantes de origen vegetal. Efecto sobre el envejecimiento

    OpenAIRE

    Descalzo Perea, Virginia

    2016-01-01

    Este trabajo consiste en una revisión bibliográfica sobre diferentes tipos de antioxidantes de origen vegetal que podemos encontrar en los alimentos, así como sus características y efectos principales. Los radicales libres más frecuentes son los derivados del oxígeno y se producen como consecuencia de las reacciones de oxidación, que constituyen una parte esencial del metabolismo. Cuando la producción de radicales libres excede a la defensa antioxidante se da un desequilibrio y, como consecue...

  16. Recursos bibliográgicos sobre los estudios en italiano

    OpenAIRE

    Caprara, Giovanni

    2009-01-01

    Este artículo bibliográfico busca ofrecer una visión panorámica actualizada (y representativa) de los Estudios de Traducción en lengua italiana. En ella se clasifican por temas objeto de estudio toda una serie de obras (libros, monografías colectivas, etc.) que inciden sobre el estudio de la Traducción e Interpretación desde la perspectiva de la lengua y la cultura italianas o que, aunque hayan sido realizados por autores extranjeros, su publicación utiliza como lengua vehicular de comunic...

  17. Sobre las implicaciones normativas de la neurociencia social

    OpenAIRE

    Salles, Arleen

    2013-01-01

    En las últimas décadas, la neurociencia y la psicología cognitiva nos ha permitido comenzar a entender la relación entre procesos psicológicos diversos y hasta sobre las bases neurológicas de las creencias, las emociones, los juicios y las decisiones morales. Pese a la aceptada distinción entre el carácter descriptivo de la ciencia y el normativo de la moralidad, algunos autores afirman que los resultados de los estudios neurocientíficos tienen implicaciones normativas. No es c...

  18. El informe mundial sobre la violencia y la salud.

    OpenAIRE

    Etienne G. Krug; James A. Mercy; Linda L. Dahlberg; Anthony B. Zwi

    2002-01-01

    En 1966, la Organización Mundial de la Salud declaró la violencia como uno de los principales problemas de salud pública. Para dar seguimiento a dicha resolución, el 3 de octubre de este año, la OMS publicó el primer Informe mundial sobre la violencia y la salud, el cual analiza los diferentes tipos de violencia, incluidos el maltrato y abandono de menores, la violencia entre los jóvenes, la violencia contra la pareja, la violencia sexual, el maltrato a ancianos, la violencia autoinfligida y ...

  19. Información sobre deporte femenino: el gran olvido

    OpenAIRE

    Ibáñez, Eugenia

    2001-01-01

    Las referencias al deporte femenino en los diarios de información deportiva han llegado a mínimos difícilmente superables. Prensa, radio y televisión han llegado a la conclusión por la vía de los hechos consumados de que el hombre es el único merecedor de convertirse en noticia en los medios informativos. La prensa deportiva y las secciones de deporte de los diarios de información general ignoran sistemáticamente a la mujer deportista, no informan sobre sus actividades, lo hacen mal y a desti...

  20. Stuart Hall sobre “hacer estudios culturales”

    OpenAIRE

    Mato, Daniel; Universidad Nacional Tres de Febrero (Untref), Buenos Aires, Argentina

    2016-01-01

    Traducción de Emeshe Juhász MininbergEmeshe Juhász Mininberg es escritora e investigadora independiente. Doctora en Filosofía y Letras, Yale University, Estados Unidos. Traductora y editora de textos de crítica cultural y de artes plásticas. Ha publicado varios artículos sobre ciudadanía, cultura e identidad nacional en tiempos de globalización, que aparecen, entre otros, en Cultura, política y sociedad: perspectivas latinoamericanas (Clacso, 2005) y en el Diccionario de estudios culturales l...

  1. Efectos de instrumentos odontológicos sobre los marcapasos

    OpenAIRE

    Gómez Val, Gonzalo

    2014-01-01

    L’ús del marcapàs ha creat un tipus particular de precaucions postoperatòries. Alguns dels problemes no son coneguts, altres problemes s'han conegut mitjançant els problemes ocorreguts. Actualment, les instruccions dels localitzadors electrònics d’àpex i els piezoelèctrics contraindiquen la seva utilització en pacients portadors de marcapassos, però, aquesta preocupació pel que fa a efectes possibles negatius, està basada en l'especulació sobre el risc potencial de les interferències electro...

  2. Nota complementar sobre o famoso chute de Pelé

    OpenAIRE

    Ferreira, G.F. Leal

    2005-01-01

    Baseado nos dados levantados e calculados em recente artigo publicado nesta revista, de autoria de C.E. Aguiar e G. Rubini [1] sobre o famoso chute de Pelé na Copa do Mundo do México de 1970, obtem-se a posição em que a impulsão foi aplicada à bola. Based on monitored and calculated data performed in recent article published in this journal, by C.E. Aguiar and G. Rubini [1] about the famous Pelé kick in the 1970 Mexico World Cup, the position where the impulse was applied on the ball is ca...

  3. Notas sobre tres especies de Gigartinaceae (Rhodophyta del litoral peruano

    Directory of Open Access Journals (Sweden)

    Martha Calderón

    2011-05-01

    Full Text Available La gran variabilidad morfológica de la familia Gigartinaceae ha producido constantes cambios taxonómicos en sus especies miembros. Tradicionalmente su taxonomía ha estado basada en caracteres de la morfología externa; sin embargo, recientes estudios morfológicos, respaldados con trabajos moleculares, han delimitado los géneros en base a al desarrollo del cistocarpo y de los tetrasporangios. El presente trabajo revisa y comenta sobre las estructuras morfológicas vegetativas y reproductivas de tres especies presentes en Perú: Chondracanthus chamissoi, Mazzaella denticulata y Chondrus canaliculatus.

  4. Regimen de propiedad sobre recursos genericos y conocimiento tradicional

    OpenAIRE

    Nemogá Soto, Gabriel R.

    2013-01-01

    Este artículo expone los cambios históricos que se han dado en relación con la propiedad, el control y el acceso a los recursos genéticos. Desde su consideración como patrimonio común de la humanidad, los derechos sobre el material y la información genética han sufrido profundas transformaciones. El marco jurídico internacional concerniente a estos derechos se ha transformado para legitimar y promover su apropiación y monopolización. Parte de esta transformación fue la expansión de derecho...

  5. Narrativas sobre conjugalidade de mulheres que se relacionam com crossdressers

    OpenAIRE

    Vencato, Anna Paula

    2017-01-01

    Resumo: Este texto discute dados coletados em pesquisa com mulheres que se identificam como “esposas” ou “S/O’s” de homens que “praticam crossdressing”. É, também, um desdobramento de minha tese de Doutorado, sobre como homens que se identificam como crossdressers negociam esta prática em suas vidas cotidianas. A pesquisa parte de uma etnografia e é complementada por entrevistas semiestruturadas com estas mulheres. Busca-se compreender como elas lidam com as tensões relativas às convenções so...

  6. Declaración sobre la Crisis Migratoria Mundial

    OpenAIRE

    Villaseñor-Bayardo, Sergio Javier; Alarcón, Renato; Rohlof, Hans

    2016-01-01

    En este artículo se presenta una versión resumida de la Declaración sobre la Crisis Migratoria Mundial (1), suscrita por la Asociación Mundial de Psiquiatría Cultural en el marco del Congreso Desafíos globales y psiquiatría cultural: Desastres naturales, conflictos, inseguridad, migración y espiritualidad -sostenido en Puerto Vallarta, Jalisco, México, del 29 de octubre al 2 de noviembre de 2015-. El tema principal abordado por la declaración es la actual crisis migratoria mundial, causada, e...

  7. Declaración sobre la Crisis Migratoria Mundial

    OpenAIRE

    2015-01-01

    En este artículo se presenta una versión resumida de la Declaración sobre la Crisis Migratoria Mundial (1), suscrita por la Asociación Mundial de Psiquiatría Cultural en el marco del Congreso Desafíos globales y psiquiatría cultural: Desastres naturales, conflictos, inseguridad, migración y espiritualidad —sostenido en Puerto Vallarta, Jalisco, México, del 29 de octubre al 2 de noviembre de 2015—.  El tema principal abordado por la declaración es la actual crisis migratoria mundial, causad...

  8. Aplicaciones sobre plataformas de redes neuronales en tiempo real

    OpenAIRE

    Tosini, Marcelo Alejandro; Acosta, Nelson

    2003-01-01

    El presente trabajo pretende el diseño de una metodología para la construcción de aplicaciones basadas en redes neuronales sobre una plataforma Muren. Las aplicaciones se restringen a sistemas de control y reconocimiento de patrones por imágenes. Se describe la arquitectura del sistema de desarrollo Muren, basado en 2 procesadores ZISC de 78 neuronas cada uno, una FPGA Spartan II, bancos de memoria y lógica adicional de comunicación.

  9. Tendências de pesquisas brasileiras sobre mulheres mastectomizadas

    OpenAIRE

    Azevedo, Elisângela Braga de; Bezerra, Pollyana Amorim Ponce de Leon; Neto, José Melquiades Ramalho; Bustorff, Leila Alcina Correia Vaz; Souto, Cláudia Maria Ramos Medeiros

    2012-01-01

    Objetivou-se analisar as tendências das pesquisas realizadas no Brasil sobre mulheres mastectomizadas. Trata-se de um estudo bibliográfico de abordagem quantitativa, realizado de 15 de junho a 31 de julho de 2009. Para coleta dos dados empíricos utilizou-se um instrumento estruturado, posteriormente os dados foram tabulados, analisados, transformados em porcentagens e agrupados em uma tabela para facilitar a visualização das informações. A amostra foi constituída por resumos adquiridos atravé...

  10. Segurança e estudos sobre a paz

    OpenAIRE

    Couto, Abel Cabral

    2000-01-01

    O autor começa por expor sucintamente as principais teorias sobre a origem da guerra: teleológicas, bio-sociológicas e evolucionistas, equacionando de seguida três modelos de relacionamento entre a segurança e a paz: equilíbrio estratégico, segurança colectiva e Governo mundial. Até fim da Guerra Fria o Sistema Internacional era, essencialmente, um sistema de relacionamento interestatal, sendo que o problema da segurança se reportava à segurança entre Estados. O autor caracteriza ...

  11. Material audiovisual sobre el mausoleo del mambisado guantanamero

    Directory of Open Access Journals (Sweden)

    Jorge Vidal Gamayo

    2017-11-01

    Full Text Available El material está relacionado con la historia de la provincia Guantánamo, específicamente el mausoleo al mambisado, y es resultado de varias investigaciones relacionadas por parte de estudiantes y trabajadores de la Universidad de Ciencias Pedagógicas “Raúl Gómez García”. Aparecen los hechos históricos acontecidos el 24 de febrero de 1895 en La Confianza, con una descripción de las reliquias históricas sobre la guerra de independencia.

  12. Producción cepalina sobre educación

    OpenAIRE

    Fernando Díaz Ortega

    2005-01-01

    El siguiente trabajo presenta una visión global del conjunto de la producción de la Comisión Económica para América Latina y el Caribe (CEPAL) sobre educación, mediante la clasificación y análisis de las publicaciones cepalinas relacionadas con el tema educativo desde 1949 hasta 2002. Para dar esa visión dividí los documentos bajo tres criterios temporales y bajo cuatro clasificaciones. Los criterios temporales fueron: anualmente, en dos periodos (1949-1976 y 1977-2002) y en seis etapas (1949...

  13. Seis Tesis no convencionales sobre participación

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    Bernardo Kliksberg

    1999-08-01

    Full Text Available Si bien hasta hace pocos años la participación generaba mucha polémica, actualmente se esta transformando en un consenso y gran parte de los organismos internacionales la están adoptando como estrategia de acción. Este trabajo plantea una serie de tesis sobre aspectos claves del tema. El objetivo no es dar un tratamiento exhaustivo a ninguno de los temas planteados, sino estimular el análisis colectivo de la misma.

  14. Stuart Hall sobre raza y racismo: estudios culturales y la práctica del contextualismo

    Directory of Open Access Journals (Sweden)

    Lawrence Grossberg

    2006-01-01

    Full Text Available El trabajo de Stuart Hall sobre la raza no puede separarse de su trabajo sobre los estudios culturales, y en particular, de su compromiso con un contextualismo radical. En este artículo, argumento que la obra de Stuart Hall sobre raza y racismo en el contexto de su compromiso de larga data con una práctica radicalmente contextualista y con la noción de la especificidad histórica en particular.

  15. Rozwój morfologiczny i sprawności specjalnej 13 – letnich chłopców trenujących piłkę nożną w Klubie Sportowym „Pogoń” Łobżenica = Morphological and a special efficiency development 13-years old boys soccer summer training in a sports club "Chase" Łobżenica

    Directory of Open Access Journals (Sweden)

    Mariusz Klimczyk

    2016-07-01

      Słowa kluczowe: test, sprawność fizyczna, sprawność specjalna, piłka nożna, rozwój morfologiczny.   Abstract The aim of the work was to identify the morphological development and efficiency of a special 13-years old boys soccer summer training in "Chasing" Łobżenica. The test group consisted of 17 players who attended training classes three times a week (training unit was 60 minutes. In addition, participated four times a week in physical education classes in school. The study took place in two periods: the first in August 2015, and the second in April 2016. Measured weight and height of the body and was carried out "technical performance for boys aged 10-14 years old," George Talaga. There was progress and large diversity of subjects. Correlation between morphological features, and obtained points in the test performance special was released to moderate the relationship between these characteristics. The work shows that when the young player does not attend regularly for training, no progression of their skills. It is therefore necessary to systematic monitoring by the skill level of students, and applying adjustments in the training plan to in the future make it easier to eliminate this phenomenon. Keywords: test, physical fitness, the efficiency of the special, football, morphological development.

  16. Seguridad en redes y sistemas : Técnicas y conceptos sobre hacking y pentesting

    OpenAIRE

    Jiménez Jiménez, Cristian

    2016-01-01

    El siguiente documento trata sobre seguridad informática. Se detallarán técnicas y conceptos sobre seguridad en redes y sistemas, pentesting y auditorías de seguridad. El següent document tracta sobre seguretat informàtica. Es detallaran tècniques i conceptes sobre seguretat en xarxes i sistemes, pentesting i auditories de seguretat. The following document is about computer security. Techniques and network security concepts and systems, pentesting and safety practices will be described....

  17. Celulas solares e sensores de filme fino de silicio depositados sobre substratos flexiveis =

    Science.gov (United States)

    Pinto, Emilio Sergio Marins Vieira

    Celulas solares flexiveis de filmes finos de silicio sao geralmente fabricadas a baixa temperatura sobre substratos de plastico ou a mais elevadas temperaturas sobre folhas de aco. Esta tese reporta o estudo da deposicao de filmes finos sobre diferentes substratos de plastico, transparentes e coloridos, para celulas solares do tipo sobrestrato e substrato, respectivamente. Como objetivo co-lateral, os filmes dopados depositados sobre plastico foram usados como sensores de deformacao, utilizando as suas propriedades piezo-resistivas. Elevadas taxas de deposicao dos filmes de silicio depositados sobre plastico foram obtidas a baixa temperatura do substrato (150ºC) por rf-PECVD. A influencia de diferentes parametros de deposicao sobre as propriedades e taxa de deposicao dos filmes resultantes foram estudados e correlacionados. Celulas solares de filmes finos de silicio amorfo e microcristalino foram desenvolvidas a baixas temperaturas sobre plasticos. Eficiencias de 5 - 6.5% foram alcancadas para as celulas amorfas e 7.5% para as celulas microcristalinas. Efeitos de aprisionamento da luz foram estudados atraves da texturizacao por ablacao laser de substratos de plastico e corrosao umida de TCO sobre plastico. Filmes finos de silicio microcristalino, depositados por HW-CVD, com fator piezoresistivo de -32.2, foram usados para fabricar sensores de deformacao em uma membrana plastica muito fina (15 μm). Estruturas de teste em textil e a miniaturizacao dos sensores piezoresistivos depositados sobre substratos flexiveis de poliimida foram abordados.

  18. Análisis sobre consumo de carne porcina en la Argentina : relevamiento sobre una población seleccionada

    OpenAIRE

    Marchese, Nicolás Gaspar; Alippe, María Victoria; Vieites, Carlos María; López, María Virginia; De Caro, Adriana E. J.

    2002-01-01

    p.179-184 La carne porcina es la de mayor consumo en el mundo; en la Argentina tiene baja incidencia en el consumo total de carnes, especialmente en estado fresco. Se carece de antecedentes publicados para determinar las causas culturales y/o de información que provocan este comportamiento. Se realizó una encuesta de opinión sobre preferencias en el consumo de carnes, utilizando el Muestreo Aleatorio Estratificado con muestras de la población de la Facultad de Agronomía (UBA). No se observ...

  19. La ceguera como motivo en Ensayo sobre la ceguera de José Saramago e Informe sobre ciegos de Ernesto Sábato

    OpenAIRE

    Fonseca, Marco Antonio

    2008-01-01

    El trabajo de investigación, El motivo de la ceguera en el Ensayo sobre la ceguera de José Saramago e Informe sobre ciegos de Ernesto Sábato, analiza desde el área y la metodología de la literatura comparada el uso del motivo literario de la ceguera en los dos textos mencionados, resaltando las similitudes y diferencias del tratamiento del motivo dentro de las dos obras y como éste sostiene una serie de obsesiones e ideas sobre el estado actual del mundo que comparten los autores de las dos n...

  20. Familias reconstituidas: Un estudio sobre las nuevas estructuras familiares

    Directory of Open Access Journals (Sweden)

    ISABEL ESPINAR FELLMANN

    2003-01-01

    Full Text Available En la mayoría de las investigaciones sobre la familia, los estudios se han centrado en las familias intactas o primeras familias. Sin embargo, es cada vez mayor el número de familias cuya configuración incluye un segundo matrimonio e hijos de una unión anterior (i.e. familias reconstituidas. En la consolidación del complejo proceso de ajuste de estas familias se han identificado unas fuentes comunes de estrés relacionadas principalmente con la formación de un nuevo sistema familiar. El objetivo de este artículo es realizar una revisión de las variables que inciden en el bienestar y/o malestar psicológico sobre una muestra de padrastros y madrastras españoles en el seno de estas nuevas configuraciones familiares. En una primera fase se realizaron, desde un diseño cualitativo, 20 entrevistas en profundidad a una muestra de padrastros y madrastras. En una segunda fase, se diseñó un cuestionario que fue respondido por 77 sujetos con la finalidad de analizar la posible relación entre alguna de las variables estudiadas.

  1. A etnografia das ruas: notas sobre estudar e ser estudado

    Directory of Open Access Journals (Sweden)

    Hecht, Tobias

    2002-01-01

    Full Text Available Passeando entre as notas e as lembranças de dois períodos distintos de trabalho de campo, este ensaio "impressionista" trata da dinâmica em mudança de uma relação de pesquisa com crianças de rua. Em 1992-1993, conduzi trabalho de campo para uma dissertação sobre crianças de rua no nordeste brasileiro. Retornando à região seis anos mais tarde, descobri que a maioria das crianças estudadas apenas uma fração de geração antes estavam então mortas. Estas anotações enfocam minhas conversas com um dos sobreviventes e com quem (e sobre quem estou agora escrevendo uma biografia. Esse esforço colaborativo, voltado de certo modo a reconsiderar as implicações éticas da pesquisa com crianças que levam vidas violentas e vulneráveis, levanta uma gama de novos desafios éticos, alguns dos quais inteiramente imprevistos

  2. Notas sobre palmas colombianas y una del Brasil

    Directory of Open Access Journals (Sweden)

    Dugand Armando

    1941-11-01

    Full Text Available Por mucho tiempo se ha creído que la palma de moriche de los Llanos orientales, en la región del Meta, era la Mauritia flexuosa L. f., especie típica del genero y originaria de Surinam. Al menos todas las obras botánicas publicadas por autores colombianos sobre la flora de nuestro país coinciden en la identificación anotada, incluso mi reciente trabajo sobre las Palmas de Colombia (Caldasia: 1: 22 y 32. 1940. Sin embargo, en este último trabajo, -que no es más que una nómina preliminar de las palmas descritas o señaladas en Colombia mientras adelanto su estudio sistemático en detalle, -identifiqué como Mauritia minor Burret unos frutos procedentes del Meta y sólo incluía la M. flexuosa ateniéndome a los autores que había consultado, suponiendo que ellos estarían en lo cierto respecto a la existencia de esta especie en Colombia, ya que no contaba yo con material autentico colombiano de la misma. Creía pues que realmente existieran ambas especies, M. flexuosa L.f.. y M. minor Burret, en nuestros Llanos, pero circunstancias recientes han venido a rectificar mi criterio.

  3. Apontamentos para o debate sobre o pleno emprego no Brasil

    Directory of Open Access Journals (Sweden)

    Fernando Augusto Mansor de Mattos

    2015-08-01

    Full Text Available RESUMOEste artigo analisa a evolução dos indicadores de emprego e de desemprego na economia brasileira desde o início dos anos 2000 até os dados referentes a 2012, tomando como referências teóricas a formulação de Keynes sobre o desemprego involuntário e também os estudos sobre a dinâmica das relações entre setor formal e setor informal dos mercados de trabalho formulados por autores ligados ao Prealc. O artigo apresenta um exercício econométrico (que teve por base a função emprego de Keynes explicada pelo Princípio da Demanda Efetiva que revela que o crescimento do emprego é uma função positiva do crescimento econômico. Dados adicionais mostram que, a despeito do crescimento da ocupação e da formalização do emprego ocorrida no período, com consequente queda da taxa de desemprego para patamares historicamente baixos, a economia brasileira não conseguiu, segundo as referências teóricas adotadas, atingir o pleno emprego ao final do período analisado, devido à persistência de parcela expressiva de mão de obra subutilizada no mercado de trabalho.

  4. Sobre el uso de conceptos comprensivos en los Ciencias Sociales

    Directory of Open Access Journals (Sweden)

    LUIS NÚÑEZ LADEVÉZE

    1985-01-01

    Full Text Available Se comparan los conceptos particulares, que describen la diversidad de los datos, y los conceptos generales, que se ocupan de los valores de las variables. En Ciencias Naturales, la generalización es el objetivo del conocimiento ; sin embargo, en las Ciencias Sociales, lo que se persigue es la consistencia del significado de los datos, mientras que la generalización es sólo un medio de conocimiento. D. Bell, en The Coming of the Post-Industrial Society, interpreta conjuntamente lo peculiar de la individualidad, del intérprete, del texto, de la acción o el conjunto de acciones, y de los contextos institucionales, sociales e históricos. Los estudios modernos de Pragmática y crítica textual aportan nuevas nociones sobre el texto como un producto de la actividad del intérprete, y sobre el contexto como el medio en el cual se realiza la actividad. Una ciencia social orientada hacia las ciencias del espíritu puede basarse en esos instrumentos teóricos. La Filosofía, la Sociología del Lenguaje, las teorías de la acción y el texto se unifican en una ciencia conjunta de alcance social e histórico.

  5. Comportamento da cajazeira enxertada sobre umbuzeiro em Pacajus-CE

    Directory of Open Access Journals (Sweden)

    Souza Francisco Xavier de

    2002-01-01

    Full Text Available A cajazeira é uma fruteira da família Anacardiaceae, explorada extrativamente, cujos frutos são nuculânios amarelos, de sabor agridoce, perfumados, ricos em carotenóides, açúcares, vitaminas A e C, denominados de taperebá, cajá-mirim ou cajá e muito utilizados na alimentação humana. Os problemas mais limitantes ao cultivo da cajazeira são a inexistência de clones recomendados para cultivo comercial e o elevado porte da planta. A cajazeira enxertada sobre umbuzeiro apresenta compatibilidade e afinidade entre as partes enxertadas e pouco interfere na forma de crescimento da planta, que é muito semelhante à de planta oriunda de semente, ou seja, tendência em formar caule de haste única e copa alta. A cultura ainda exige estudos sobre as modalidades e épocas de realização das podas para o controle do crescimento da planta e formação de copas que se enquadrem dentro de modelos de exploração intensiva.

  6. Nuevas reflexiones sobre la Posgerontología

    Directory of Open Access Journals (Sweden)

    Ricardo Iacub

    2014-03-01

    Full Text Available La Posgerontología plantea una lectura epistemológica, crítica y política sobre los relatos con los que se construye el envejecimiento y la vejez desde la gerontología. En este artículo se analizará crítica y políticamente a la gerontología, tanto como un objeto cultural exótico - por su pretensión omnicomprensiva -, como por ser un campo de conocimientos cuyos presupuestos explícitos e implícitos inciden sobre su objeto de estudio. Estos factores ponen en consideración los ajustes que debe realizar todo campo de conocimiento frente a los cambios que le imprime el contexto. Así como también expresan la necesidad de dar cuenta de los efectos de la realidad que construyen en las diversas formas de saber y en las prácticas sociales.

  7. Sobre fuentes, temporalidad y escritura de la historia

    Directory of Open Access Journals (Sweden)

    Germán Colmenares

    1987-01-01

    Full Text Available Una exposición sobre métodos históricos no puede reducirse a una mera colección de recetas sobre la manera como debe conducirse una investigación desde el momento en que se selecciona un tema monográfico, se localizan las fuentes aprovechables y se someten a variados procedimientos críticos y cuantitativos, hasta cuando se acomete la empresa final de la presentación narrativa o analítica de los resultados. Cada uno de estos pasos ha recibido un énfasis diferente en diferentes épocas, tipificando así una escuela o toda una manera de concebir la tarea historiográfica. El primero de ellos, por ejemplo, no parece recelar mayores dificultades. Sin embargo, cuando en él se considera incluido el planteamiento de un problema y la identificación de los elementos que lo constituyen, entonces resulta encerrar el mayor número de cuestiones teóricas.

  8. Letalidad de hongos entomopatogenos sobre Dysdercus peruvianus (Hemiptera: Pirrhocoridae

    Directory of Open Access Journals (Sweden)

    Francesca Falconi

    2011-05-01

    Full Text Available Se evaluó la patogenicidad y virulencia sobre Dysdercus peruvianus de una cepa de Acremonium y una de Scopulariopsis, aisladas de adultos infectados de D. peruvianus procedentes de Mala, Provincia de Cañete. También se evaluó una cepa de Beauveria sp. aislada de Schistocerca piceifrons peruviana procedente de Ayacucho. Los bioensayos se realizaron sobre ninfas del cuarto estadío de D. peruvianus y las concentraciones empleadas fueron 3,7x108, 1,9x108, 9,4x107 conidias/mL para Beauveria sp., Acremonium sp. y Scopulariopsis sp. respectivamente. Veinte días posteriores al tratamiento, los mayores porcentajes de mortalidad los causaron Beauveria sp. (83,3% y Acremonium sp. (80%. Scopulariopsis sp. causo una mortalidad de 23,3%. Acremonium sp. fue la cepa más agresiva con un tiempo de letalidad (TL50 3,8 días.

  9. Algumas anedotas sobre Demóstenes: uma releitura

    Directory of Open Access Journals (Sweden)

    Maddalena Vallozza

    2013-06-01

    Full Text Available Muitas das anedotas sobre Demóstenes estão relacionados a seus problemas de voz e a suas dificuldades no momento da hypokrisis. Eu proponho uma reinterpretação das páginas em que eles nos são transmitidos: de Quintiliano (11, 3, a principal testemunha, a Cícero (Orator 26 e 56-58, Brutus 142, De Oratore I 261 e III 213, do autor da seção sobre Demóstenes nas Vidas dos Dez Oradores (844 d-845 b à Vida de Demóstene, de Plutarco. Com base nisso, particularmente graças a Plutarco, que cita Hermipo e Demétrio de Fáleros, é possível formular a hipótese de que a tradição nasceu no Perípato, na área de interesses pela hypokrisis que demonstram o perdido Perì hypokríseos de Teofrasto e os fragmentos da Retórica de Demétrio de Fáleros.

  10. EFECTOS DEL MERCURIO SOBRE ALGUNAS PLANTAS ACUÁTICAS TROPICALES

    Directory of Open Access Journals (Sweden)

    Martha Isabel Posada

    Full Text Available El presente artículo es una descripción de los efectos del mercurio sobre algunas plantas acuáticas tropicales y sobre los ecosistemas donde habitan. Adicionalmente, se recomienda un protocolo para realizar pruebas de toxicidad con la lenteja de agua (Lemna minor y se presentan los resultados de los preensayos con diferentes concentraciones de sales de mercurio en condiciones de laboratorio. Se encontró que la biodisponibilidad del mercurio depende de factores que facilitan la disolución del elemento en el agua. Algunas plantas actúan como bioindicadores de la presencia de este metal en el medio al retenerlo selectivamente; mientras que otras se comportan como bioacumuladoras al tolerar su presencia y acumularlo en su estructura, y pueden dar paso a la bioconcentración a través de la cadena trófica. De acuerdo con los preensayos de toxicidad realizados con Lemna minor se sugiere que las concentraciones de sal de mercurio adecuadas para la realización de pruebas de toxicidad deben estar entre 0,01 mg/L y 10,0 mg/L.

  11. Deus sobre as pedras: Guilherme Figueiredo em Israel

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    Filipe Amaral Rocha de Meneses

    2010-03-01

    Full Text Available Entre 1963 e 1964, Guilherme Figueiredo – teatrólogo, romancista e crítico de teatro brasileiro – fez uma viagem a Israel, na época uma ainda jovem nação de quinze anos. Essa viagem resultou em Deus sôbre as pedras: Israel, publicado em 1965. O livro contém assuntos variados relativos a Israel, desde explicações sobre a formação do Estado, crítica teatral de autores israelenses e explicação sobre como são constituídos os kibutzim. O objetivo deste artigo é analisar este relato, tomando por base: as descrições dos locais históricos visitados pelo autor, a critica e a interpretação da cultura nacional israelense em formação e os diálogos e encontros que Figueiredo mantem com brasileiros que viviam em Israel – conversas nas quais o principal assunto era a comparação entre a cultura brasileira e a cultura israelense em formação.

  12. Precisiones sobre la luz en el Pantheon de Roma

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    Oscar Linares de la Torre

    2015-04-01

    Full Text Available El Pantheon de Adriano es una de las obras más celebradas de la historia de la arquitectura. Han sido muchas las cuestiones que han cautivado a cuantos han entrado en él, pero es la luz la que ha acaparado el mayor protagonismo: una vez despojado el edificio de su originaria carga simbólica, la manifestación de su luz interior parece ser el único fin de este inmenso espacio-luz que tanto ha fascinado a arquitectos, historiadores del arte, pintores y fotógrafos. Parece difícil poder aportar nada nuevo. Consciente de ello, el autor del presente artículo sólo pretende apuntar algunas cuestiones sobre distintos aspectos de la luz en el Pantheon que considera que no han sido aún suficientemente desarrolladas: el por qué de la orientación solar y urbana del templo con respecto al eje norte-sur; la reconstrucción de la secuencia de luz y sombra que debió de darse en el recorrido original de acceso al interior del templo; la interpretación del haz de luz ocular como reminiscencia inmaterial del soporte central de las falsas cúpulas etruscas, convertida en una columna de materia sutil que, sin alcanzar nunca la vertical, incide de manera variada sobre los paramentos que conforman el interior.

  13. "Sobre muros e jardins": poesia e videodança

    Directory of Open Access Journals (Sweden)

    Olga Valeska

    2014-07-01

    Full Text Available http://dx.doi.org/10.5007/1807-9288.2014v10n1p187 Neste trabalho propomos uma análise semiótica da videodança “Sobre Muros e Jardins”, promovido pelos Grupos de Pesquisa parceiros COMTE do Posling-CEFET-MG e CCODA da UFMG. Este vídeo foi produzido a partir do poema homônimo de Olga Valeska "Sobre Muros e Jardins", presente no seu livro Mundos e Mutações. Como tradução semiótica ele envolve distintas linguagens como a literária, a fílmica e a dança. Nosso objetivo é verificar como tais linguagens foram transpostas para o gênero “vídeodança”, em um processo dinâmico de mutação entre distintas texturas de imagens, sons e movimentos rítmicos.

  14. UM “ENTENDIMENTO DO ENTENDIMENTO”: OLHAR SOBRE OSABER LOCAL

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    Miriam Espindula dos Santos

    2014-09-01

    Full Text Available Primeiramente quero justificar minha opção por fazer uma síntese-resenha do livro O Saber Local: novos ensaios em antropologia interpretativa, de Clifford Geertz. A escolha se deu pela inquietação que o mesmo provocou no momento de sua leitura, o referido ensaio contribuiu de forma significante para o meu processo de (in maturação acadêmica, pessoal e de pesquisadora. A intenção é destacar os pontos mais relevantes do livro, lançar um olhar sobre algumas questões problematizadas pelo autor. Apesar de não utilizar a hermenêutica interpretativa proposta por Geertz em minha pesquisa, a mesma possibilitou muitas ideias acerca de como proceder enquanto pesquisadora, no trato que devo ter para com o meu objeto, um trato respeitoso, atencioso, aberto, com um olhar afinado para as questões que o cerca, bem como o uso de analogias para analisar determinados fatos. Destaco que o meu olhar sobre este ensaio também reflete as discussões calorosas que realizamos em sala de aula acerca do mesmo, bem como dos momentos em que analisamos os projetos de pesquisas dos colegas da turma, apesar de não me deter neste aspecto. Assim sendo, vou seguir basicamente a divisão proposta pelo ensaísta nesta obra, refletindo acerca do que mais me inquietou neste ensaio...

  15. Sobre la teoría impura del derecho

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    Danilo Rojas Betancourt

    2006-01-01

    Full Text Available La reseña hecha al libro del profesor Diego López, la Teoría impura del derecho, muestra algunos aspectos que debilitan la novedosa e importante tesis allí sostenida sobre la transformación de la teoría jurídica en Latinoamérica. En especial, señala que la particular apreciación de López sobre algunos tópicos kelsenianos deja demasiado expuesta la demostración que respecto de Kelsen proporciona como ejemplo de transformación teórica en Colombia. El reparo central radica en que la construcción hecha por López de lo que se denominaría regla de tanteo de la Teoría Transnacional del Derecho, TTD, toma como base una versión formalizada y no crítica de esta. Al hacerlo, López cae en la misma trampa que pretende mostrar como característica de la transformación local y que, conforme a la lectura estándar de cierta TTD, debe señalarse como incorrecta.

  16. Influencia do tempo de exposicao a obesidade induzida por dieta hiperlipidica sobre os colagenos tipo I e III miocardico

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    Danielle Cristina Tomaz da Silva

    2014-03-01

    Full Text Available FUNDAMENTO: A obesidade é um fator de risco para muitas complicações médicas; a pesquisa médica demonstrou que as alterações hemodinâmicas, morfológicas e funcionais estão correlacionadas com a duração e gravidade da obesidade. OBJETIVO: O presente estudo determinou a influência do tempo de exposição à obesidade induzida por dieta com alto teor de gordura no colágenos tipo I e III miocárdico. MÉTODOS: Ratos machos com trinta dias de idade, da raça Wistar, foram distribuídos aleatoriamente em dois grupos: um grupo de controle (C alimentado com ração padrão e um grupo de ratos obesos (Ob alternadamente alimentados com uma de quatro dietas palatáveis ricas em gordura. Cada dieta foi mudada diariamente, e os ratos foram mantidos em suas respectivas dietas por 15 (C15 e Ob15 e 30 (C30 e Ob30 semanas consecutivas. A obesidade foi determinada pelo índice de adiposidade. RESULTADOS: O grupo Ob15 foi similar ao grupo C15 em relação à expressão de colágeno miocárdico tipo I; contudo, a expressão no grupo Ob30 foi menor do que no grupo C30. O tempo de exposição à obesidade foi associado com uma redução de colágeno do tipo I no grupo Ob30, quando comparado com o Ob15. A obesidade não afetou a expressão do colágeno tipo III. CONCLUSÃO: Este estudo mostrou que o tempo de exposição à obesidade por 30 semanas induzida por uma dieta rica em gordura insaturada causou uma redução na expressão do colágeno miocárdico tipo I em ratos obesos. No entanto, nenhum efeito foi observado em relação à expressão do colágeno miocárdico tipo III

  17. Considerações sobre cuidado paliativo e trabalho hospitalar: uma abordagem plural sobre o processo de trabalho de enfermagem

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    Miguel de Simoni

    2003-01-01

    Full Text Available O objetivo deste artigo é apresentar o esforço de síntese dos autores sobre material de pesquisa em cuidados paliativos e bibliografia estudada. Inicialmente, apresentamos algumas considerações sobre cuidado paliativo em dois países estruturalmente distintos, Brasil e França. A discussão está centrada nas experiências de pesquisa dos autores em um serviço de AIDS no Brasil e em um serviço de Medicina Interna na França, que adotava a lógica dos cuidados paliativos e abrigava predominantemente pacientes com AIDS e câncer. Abordamos, em seguida, aspectos referidos à dor e à morte, considerando conceitos da Bioética e a dimensão relacional do cuidado em saúde. Os conceitos assinalados são os de justiça, autonomia, beneficência e não-maleficência. Concluímos, apresentando algumas possíveis contribuições da Ergonomia e da Psicodinâmica do Trabalho na área de Cuidados Paliativos, considerando especialmente a dimensão psicológica deste debate.

  18. Contabilidad de Costos I. - Problemas sobre contabilización de las actividades relacionadas con los materiales

    OpenAIRE

    Morillo Moreno, Marysela C.

    2008-01-01

    ÍNDICE Introducción Problemas sobre terminología básica Problemas básicos sobre el Ciclo de la Contabilidad de Costos Problemas sobre contabilización de las actividades relacionadas con los materiales Problemas sobre la contabilización de las actividades relacionadas con la mano de obra Problemas sobre la contabilización de las actividades relacionadas con los costos indirectos de fabricación Problemas sobre el Ciclo de la Contabilida...

  19. Contabilidad de Costos I. - Problemas sobre la contabilización de las actividades relacionadas con la mano de obra

    OpenAIRE

    Morillo Moreno, Marysela C.

    2008-01-01

    ÍNDICE Introducción Problemas sobre terminología básica Problemas básicos sobre el Ciclo de la Contabilidad de Costos Problemas sobre contabilización de las actividades relacionadas con los materiales Problemas sobre la contabilización de las actividades relacionadas con la mano de obra Problemas sobre la contabilización de las actividades relacionadas con los costos indirectos de fabricación Problemas sobre el Ciclo de la Contabilida...

  20. Eflorescencias y costras sobre areniscas de Villamayor. Ensayos de laboratorio

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    Madruga, F.

    1994-06-01

    Full Text Available Accelerated tests carried out in the laboratory allow us to study the crystalline material settled over the surface of the sandstones when in contact with watery solutions of different compositions. Sandstone specimens of three different textures were placed on trays containing watery solutions, putting one surface in contact with the liquid. In order to accelarate the capillary absorption, a flow of air was established over the opposite surfaces. The humidity and dryness cycles were repeated 45 times. The crystallized salts were identified by X-ray diffraction, SEM and chemical microanalysis by X-rays dispersive energy. The following results were obtained: gypsum, hexahydrite, picromerite, natrone, arcanite in saline solutions; trone, aftitalite, and presence of gypsy m in cement solutions; gypsum and syngenite in the guano solution test. These salts are analogous to those found in the superficially damaged stones of the Cathedral of Salamanca.

    Ensayos acelerados realizados en el laboratorio, permiten estudiar el material cristalino depositado sobre la superficie de areniscas cuando están en contacto con disoluciones acuosas de diferente composición. Probetas de areniscas de tres texturas diferentes se colocan sobre bandejas que contienen las disoluciones acuosas, de tal forma que una de las superficies esté en contacto con el líquido. Sobre las superficies opuestas se establece una corriente de aire que acelere la absorción capilar del líquido. Ciclos de humedad y secado se repiten 45 veces. Las sales cristalizadas se identifican por difracción de rayos-X, SEM y microanálisis químico por energía dispersiva de rayos-X. Los resultados son los siguientes; yeso, hexahidrita, picromerita, natrón y arcanita cuando se trata de disoluciones salinas; trona, aftitalita y presencia de yeso cuando la disolución es de cemento; yeso y syngenita en el ensayo con disolución de guano. Estas sales son análogas a las encontradas en las