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Sample records for sir william james

  1. Whither Sir William?

    Directory of Open Access Journals (Sweden)

    Stephen J. Greenberg, MSLS, PhD

    2017-04-01

    Full Text Available There are times when something is simply so familiar that we can no longer see it at all. It can be a story, or a concept, or even a flesh-and-blood person. Familiarity breeds not only contempt, but a kind of invisibility as well. For too many of us, such is the case with Sir William Osler. In his time (1849–1919, many considered him to be one of the greatest practitioners, teachers, and writers ever in the field of medicine. He was instrumental in the founding of the Medical Library Association (MLA and was elected its second president.

  2. Sir William Turner (1832-1916) - Lancastrian, anatomist and champion of the Victorian era.

    Science.gov (United States)

    Wessels, Quenton; Correia, Janine Carla; Taylor, Adam M

    2016-11-01

    Sir William Turner, a Lancastrian, was renowned as a scientist, anatomist and a great reformer of medical education. His students became anatomists at various international institutions, which consequently shaped the future of anatomy as a subject matter both in the United Kingdom and in South Africa. Although Turner's accomplishments have been documented, little is known about the details that determined his career path and the individuals that shaped his future. Here the authors aim to highlight some aspects of Turner's academic achievements and his personal life as well as how he crossed paths with other great minds of the Victorian era including Richard Owen, Charles Darwin, James Paget and Joseph Lister. © The Author(s) 2015.

  3. Sir William Jenner (1815-1898) and Queen Victoria.

    Science.gov (United States)

    Seddon, David; Queen Victoria

    2004-08-01

    This biographical note outlines the work of Sir William Jenner (1815-1898), court physician 1861-93 and President of the Royal College of Physicians 1881-8. He was the first to distinguish between typhoid and typhus both clinically and pathologically.

  4. Sir James Reid and the Death of Queen Victoria: An Early Model for End-of-Life Care.

    Science.gov (United States)

    Abrams, Robert C

    2015-12-01

    An appraisal of the last ten days of Queen Victoria's life, viewed primarily from the perspective of her personal physician, Sir James Reid, is presented. Sir James' clinical encounters with his patient and the Royal Family are examined to reveal his strategic and medical thinking and gauge his level of success in basic palliative aims. It was found that the lack of effective medical interventions, tensions within the Royal Family, the importance of his post to Sir James' professional career, and the political ramifications unavoidably connected with the illness of a head of state, all presented challenges to Reid's efforts to ease the physical and emotional pain of Queen Victoria's dying. Key features of Sir James' approach included reliance on physician-patient and physician-family relationships, emphasis on emotional support for the patient, and the careful selection of interventions for the family. In the first years of the 20th century, an era when the contemporary concepts of palliative care, hospice, and family dynamics did not exist, Sir James' management of the Queen's final illness suggested an early model for end-of-life care. By the end of Queen Victoria's life, Sir James was seen to have preserved his patient's comfort and dignity, at the same time advancing family and societal acceptance of the death of this matriarchal figure. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  5. Sir James Paget: Paget's disease of the nipple, Paget's disease of bone.

    Science.gov (United States)

    Ellis, Harold

    2013-04-01

    Sir James Paget was one of the 'great' Victorians. Eminent as a surgeon, pathologist and teacher, his nobility of character and application to his work made him a leader in his profession in that age of great men.

  6. Space perception and William James's metaphysical presuppositions.

    Science.gov (United States)

    Farrell, Martin J

    2011-05-01

    William James's overtly philosophical work may be more continuous with his psychological work than is sometimes thought. His Essays in Radical Empiricism can be understood as an explicit statement of the absolute presupposition that formed the basis of Jamesian psychology: that direct experience is primary and has to be taken at face value. An examination of James's theory of space perception suggests that, even in his early work, he presupposed the primacy of direct experience, and that later changes in his account of space perception can be understood as making his view more consistent with this presupposition. In his earlier view of space perception, James argued that sensations were directly experienced as spatial, though he accepted that spatial relations between sensations may be constructed by higher order thought. In his later view, however, James argued that spatial relations were just as directly experienced as sensations. The work of T. H. Green may have prompted James to recognize the full consequence of his ideas and to realize that taking experience at face value required that spatial relations be thought of as intrinsic to experience rather than the result of intellectual construction.

  7. Sir William Osler's speech at Troy: a Trojan horse?

    Science.gov (United States)

    Moran, Michael E

    2012-01-01

    Troy, New York, is a city of 55,000 people in upstate New York located along the Hudson River. A city of surprisingly rich cultural heritage, it was the home of New York state's first hospital outside New York City. The 50th anniversary celebration of Troy's hospital brought William Osler to the city as the keynote speaker. This speech, delivered on November 28, 1900, is one of Sir William's less well known addresses. Osler began his comments with Sir Thomas More's Utopia and talked at length about the hospital, its obligations, the influences it has upon the community, and the role of physicians and surgeons. He broached one of his old saws, the salary of attending physicians and their needed role in hospital management. His words were published in the diamond jubilee's records, but the hospital did not outlive its prominent guest professor, and it closed its doors in 1914. Just like the great historical city of Troy, New York's own Troy was on the brink of decline, and its hospital would be the first fatality. Therefore, it is almost prescient that the words of Osler, taken into historical context juxtaposed against the socioeconomic forces at work, are akin to the Greek's offering of a wooden edifice to end the Trojan War.

  8. Sir William Mitchell (1925-2002)

    CERN Multimedia

    2002-01-01

    Sir William (Bill) Mitchell, former President of the CERN Council, died on 30th October 2002 at the age of 77. Mitchell was professor of Physics at Oxford University from 1978 to 1989, having previously been Professor of Physics, Dean of Science and Deputy Vice-Chancellor at Reading University. From 1985 to 1990 he was Chairman of the UK's Science and Engineering Research Council (SERC), which at the time was the funding agency for the UK's participation in the CERN programme. As Chairman, Mitchell was one of the UK representatives on the CERN Council, and in 1991 he was elected President, a position he held for three years. This was a difficult period for CERN. Financial problems were being faced in many member states, notably in Germany as a result of unification. This led to calls for reductions in the CERN budget and, more significantly, to requests for delays in consderation of future programmes. On the other hand for the future of CERN and the progress of elementary particle physics, it was necessary...

  9. William James and the Heidelberg fiasco.

    Science.gov (United States)

    Gundlach, Horst

    2018-02-01

    Urged on by his father to become a physician instead of a painter, William James pursued 3 evasion stratagems. First, to avoid becoming a practitioner, he declared that he wanted to specialize in physiology. Based upon this premise, he left for Germany in the spring of 1867. The second step was giving up general physiology and announcing that he would specialize in the nervous system and psychology. Based upon this premise, he declared that he would go to Heidelberg and study with Helmholtz and Wundt. However, he then deferred going there. When, at last, he was urged by an influential friend of his father's to accompany him to Heidelberg, he employed his default stratagem: He simply fled. He returned home after 3 terms in Europe without enrolling at a single university. There is no evidence that he had learned anything there about psychology or experimental psychology, except, possibly, by reading books. James's "Heidelberg fiasco" was the apogee of his evasion of his father's directive. A dense fog of misinformation surrounds his stay in Heidelberg to this day. By analyzing circumstances and context, this article examines the fiasco and places it in the pattern of his behavior during his stay in Europe. Nevertheless, experiencing this fiasco potentially shaped James's ambivalent attitude toward experimental psychology on a long-term basis. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  10. William James, Gustav Fechner, and Early Psychophysics

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    Stephanie L. Hawkins

    2011-10-01

    Full Text Available American psychologist and philosopher William James devoted the entirety of his career to exploring the nature of volition, as expressed by such phenomena as will, attention, and belief. As part of that endeavor, James's unorthodox scientific pursuits, from his experiments with nitrous oxide and hallucinogenic drugs to his investigation of spiritualist mediums, represent his attempt to address the "hard problems" of consciousness for which his training in brain physiology and experimental psychology could not entirely account. As a student, James's reading in chemistry and physics had sparked his interest in the concepts of energy and force, terms that he later deployed in his writing about consciousness and in his arguments against philosophical monism and scientific materialism, as he developed his radically empiricist ideas privileging discontinuity and plurality. Despite James's long campaign against scientific materialism, he was, however, convinced of the existence of a naturalistic explanation for the more "wayward and fitful" aspects of mind, including transcendent experiences associated with hysteria, genius, and religious ecstasy. In this paper, I examine aspects of James's thought that are still important for contemporary debates in psychology and neuroscience: his "transmission theory" of consciousness, his ideas on the "knowing of things together," and, finally, the related concept of "the compounding of consciousness," which postulates the theoretical possibility for individual entities within a conscious system of thought to "know" the thoughts of others within the system. Taken together, these ideas suggest that James, in spite of, or perhaps because of, his forays into metaphysics, was working toward a naturalistic understanding of consciousness, what I will term a "distributive model," based on his understanding of consciousness as an "awareness" that interacts dynamically within, and in relation to, its environment.

  11. Bases do pensamento fenomenológico e existencial em William James

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    Ana Maria Lopez Calvo de Feijoo

    Full Text Available Neste artigo, temos por objetivo investigar os fundamentos e as bases do pensamento fenomenológico e existencial advindos da Psicologia de William James no que diz respeito à noção de consciência, método e prática clínica. Para tanto, analisamos algumas obras de James e dividimos as suas propostas em três momentos distintos: pragmatismo, funcionalismo e empirismo. Por meio das elaborações em cada um desses momentos, tentamos esclarecer os pontos de encontro e os pontos de desencontro com os pensamentos fenomenológico e existencial. Concluímos que o ponto de encontro diz respeito à tentativa de não objetivação da consciência. Quanto ao desencontro, consideramos que James ainda toma a consciência como objeto da Psicologia e que a fenomenologia e as perspectivas existenciais se afastam da ideia de objeto, uma vez que não consideram a consciência contraposta ao mundo. Outro desencontro apresenta-se na acentuada divergência entre James e o pensamento fenomenológico e existencial no que se refere ao método e à prática bem como aos objetivos da clínica.

  12. Physiology as the antechamber to metaphysics: the young William James's hope for a philosophical psychology.

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    Croce, P J

    1999-11-01

    In the 5 years before 1878, when his career in psychology was becoming established, William James wrote a series of notes and reviews assessing the work of many of the pioneers in the new field. Adopting a public and confident voice, even while he was privately still uncertain and searching, James criticized the dogmatism of positivist and idealist claims to the study of the human brain and mind. In his short writings of 1873-1877, James started to formulate his own middle path. His first steps on that path show that he did not reject either scientific or philosophic inquiry; instead, he viewed scientific knowledge as a way to understand philosophical questions more deeply. Saving his sharpest critiques for positivism, James endorsed scientific investigation without materialist assmptions. While his career in psychology was still only a hope, James treated science as a means toward humanist insight.

  13. Religious Experience and its Essentialism in William James and Ghazzali’s Views

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    Ahmad Ebadi

    2016-03-01

    Full Text Available Abstract Religious experience is an approach to which Western thinkers are considered pioneers among whom Schleiermacher is the most prominent. "The essentialism of religious experience" is one of the several approaches that have been adopted in the case of religious experience. Accordingly, the religion that has sides and various dimensions has been reduced to a religious experience and the religious experience is introduced as the essence of religion. What is presented in this article is a comparative study of the essence of religious experience from the perspective of William James and Ghazzāli. Although mystical experience has a different structure form the religious experience and Ghazali as well as other Muslim philosophers and mystics paid more attention to the way of mystical experience, in the works of Ghazali there are also a traces of religious experience and hence, they are adaptable to some aspects of religious experience offered by William James. William James defines the religion “as the feelings, acts, and experiences that can occur for every individual in their solitudes and he believes that feeling is the essential pillar of religion and inherently reinforces it”. Religious experience is the essence of religion and it means that-the truth of the faith is the same as feelings and emotions that emerge from rational reflections on concrete reality as such, and other spiritual, transcendental, mystical and psychological actions are the consequences of these experiences. On the other hand, in the Muslim world, Al-Ghazzali believes that: The ultimate and holy aim of religion is the perception and experience of ultimate truth that can be achieved through good deeds, worship, asceticism and piety. This article tries to find similarities and differences in essence of religious experience of the two thinkers, because it is only in the theory of the essentialism of religious experience that the similarities and differences of

  14. Why bad Moods Matter. William James on Melancholy, Mystic Emotion, and the Meaning of Life

    NARCIS (Netherlands)

    H.J. Pott (Heleen J.)

    2017-01-01

    textabstractWilliam James’s reputation in the field of emotion research is based on his early psychological writings where he defines emotions as ‘feelings of bodily changes’. In his later work, particularly in his study of mystic emotion (1902), James comes up with what looks like a completely

  15. Ut Pictura Poesis : dialéctica entre palabras e imagen en Sir William Sterling Maxwell

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    Hilary Macartney

    2002-01-01

    Full Text Available En el presente artículo se analiza la estrecha relación entre la historia del arte de Sir William Stirling Maxwell, su biblioteca y su colección artística. Este vínculo encierra la clave para la comprensión de su excepcional aportación a la historiografía del arte español. Sus diversas actividades, como historiador del arte, coleccionista de libros y cuadros, y director de ediciones privadas de libros raros, fueron todas manifestaciones de su gran fascinación por el paralelo entre la literatura y el arte, la palabra y la imagen. Tal relación se encuentra incluso en el esquema decorativo de su biblioteca.This article examines the remarkable unity between Sir William Stirling Maxwell's art history, his library and his art collection and argües that this relationship is the key to understanding his unique contribution to scholarship of Spanish art. In particular, it will be shown that his actlvities as an art historian, bibliophile, art collector and editor of prívate editions of rare books were all expressions of his fascination with the relationship between literature and art in general, and more specifically between word and image. Even the decorative scheme of his library emphasised this relationship.

  16. EL CONCEPTO DE ATENCIÓN Y CONSCIENCIA EN LA OBRA DE WILLIAM JAMES/ THE CONCEPT OF ATTENTION AND CONSCIOUSNESS IN THE WORK OF WILLIAM JAMES/ O CONCEITO DE ATENÇÃO E CONSCIÊNCIA NA OBRA DE WILLIAM JAMES

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    Ana Lorena Domínguez

    2013-06-01

    Full Text Available Situar un punto inicial en la historia de la psicología para rastrear el concepto de la atención no es tarea sencilla. Esta labor indudablemente nos lleva a enfrentar viejos problemas que surgieron con la filosofía y que, con el paso de los años y de los intereses intelectuales, fueron madurando y orientándose hacia múltiples direcciones. Con el ánimo de aportar en este mapa conceptual sobre el problema de la conciencia, abordaremos la obra de un autor fundamental en esta área de estudio. El objetivo del presente texto es reconstruir parte del pensamiento de William James, especialmente sus reflexiones alrededor del concepto de atención y del campo de conciencia.

  17. Interpreting "Mind-Cure": William James and the "chief task…of the science of human nature".

    Science.gov (United States)

    Sutton, Emma Kate

    2012-01-01

    The private papers of the philosopher-psychologist, William James, indicate that he frequented several mental healers during his life, undertaking 100-200 therapeutic sessions concerning a range of symptoms from angina to insomnia. The success of the mind-cure movement constituted for James both a corroboration, and an extension, of the new research into the subconscious self and the psychogenesis of disease. Epistemologically, the experiences of those converts to the "mind-cure religion" exemplified his conviction that positivistic scientific enquiry can only reveal only one part of a wider reality. Metaphysically their reports comprised a powerful body of support for the existence of a "higher consciousness," a supernatural world of some description. The positing of such a source of "supernormal" healing power was, for James, the best way to reconcile the accounts of those who had been regenerated, via their faith, despite having exhausted all natural reserves of energy and will. © 2012 Wiley Periodicals, Inc.

  18. 'Report of the Committee on Mediumistic Phenomena', by William James (1886): With an introduction by.

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    Alvarado, Carlos S

    2016-03-01

    Mediumship was a topic of great interest to some nineteenth-century students of mental phenomena. Together with the phenomena of hypnosis and other manifestations, mediumship was seen by many as a dissociative phenomenon. The purpose of this Classic Text is to present an excerpt of an article about the topic that William James (1842-1910) published in 1886 in the Proceedings of the American Society for Psychical Research about American medium Leonora E. Piper (1857-1950). The article, an indication of late nineteenth-century interactions between dissociation studies and psychical research, was the first report of research with Mrs Piper, a widely investigated medium of great importance for the development of mediumship studies. In addition to studying the case as a dissociative experience, James explored the possibility that Piper's mentation contained verifiable information suggestive of 'supernormal' knowledge. Consequently, James provides an example of a topic neglected in historical studies, the ideas of those who combined conventional dissociation studies with psychical research. © The Author(s) 2016.

  19. Sir William Burnett (1779-1861), professional head of the Royal Naval Medical Department and entrepreneur.

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    Penn, Christopher

    2004-08-01

    Sir William Burnett (1779-1861) had an active career as a Royal Navy surgeon in the French Revolutionary and Napoleonic Wars, including service at the battles of St Vincent, the Nile and Trafalgar. From 1822 to 1855 he was professional head of the Royal Naval Medical Department, when he provided effective leadership in a time of great change. Although his official work earned him the reputation of a "hard-working, unimaginative, somewhat harsh man", his correspondence shows a very humane centre under the official carapace. His official performance and reputation were both eroded towards the end of his career by his determined promotion of zinc chloride, for which he held lucrative patents.

  20. William James on a phenomenological psychology of immediate experience: the true foundation for a science of consciousness?

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    Taylor, Eugene

    2010-01-01

    Throughout his career, William James defended personal consciousness. In his "Principles of Psychology" (1890), he declared that psychology is the scientific study of states of consciousness as such and that he intended to presume from the outset that the thinker was the thought. But while writing it, he had been investigating a dynamic psychology of the subconscious, which found a major place in his Gifford Lectures, published as "The Varieties of Religious Experience" in 1902. This was the clearest statement James was able to make before he died with regard to his developing tripartite metaphysics of pragmatism, pluralism and radical empiricism, which essentially asked "Is a science of consciousness actually possible?" James's lineage in this regard, was inherited from an intuitive psychology of character formation that had been cast within a context of spiritual self-realization by the Swedenborgians and Transcendentalists of New England. Chief among these was his father, Henry James, Sr., and his godfather, Ralph Waldo Emerson. However, james was forced to square these ideas with the more rigorous scientific dictates of his day, which have endured to the present. As such, his ideas remain alive and vibrant, particularly among those arguing for the fusion of phenomenology, embodiment and cognitive neuroscience in the renewed search for a science of consciousness.

  1. The Last Word: An Interview with Frank Pajares--God, the Devil, William James, the Little Prince, and Self-Efficacy

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    Bembenutty, Hefer

    2007-01-01

    This article presents an interview with Frank Pajares, an internationally recognized scholar in the field of motivation and self-efficacy. During the interview, Pajares talked about William James, what he learned from reading "The Little Prince," his self-efficacy beliefs, and his famous speech wherein he spoke of God, the Devil, and solving the…

  2. The Herschel objects and how to observe them exploring sir William Herschel's star clusters, nebulae, and galaxies

    CERN Document Server

    Mullaney, James

    2007-01-01

    Deep-sky observers are always on the lookout for new observing challenges. "The Herschel Objects, and How to Observe them" offers an exciting opportunity to retrace the footsteps of Sir William Herschel, discoverer of Uranus and arguably the greatest visual observer and celestial explorer that ever lived!Following a biography of Herschel that details his life and the telescopes he used, this practical observer's guide lists all the most impressive of Herschel's star clusters, nebulae and galaxies.More than 600 of the brightest of the objects that Herschel observed are covered, and there are detailed descriptions and images of almost 200 of the very best Herschel objects for amateur astronomers.

  3. James Taylor (1859-1946): favourite disciple of Hughlings Jackson and William Gowers.

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    Eadie, M J

    2013-01-01

    In neurological circles today the name James Taylor (1859-1946) is probably remembered mainly for his role in editing the Selected Writings of John Hughlings Jackson, the most readily available source of Jackson's contributions to neurological knowledge. Taylors' own neurological achievements are largely or entirely forgotten, but in his day he was an influential figure whose career linked the great figures of the golden era of late nineteenth century British neurology to the neurology of the first half of the twentieth century. Not only was he a junior professional colleague and close friend of both John Hughlings Jackson and William Gowers, he also produced a substantial corpus of neurological writings in his own right, including a textbook of child neurology and the first English language account of subacute combined degeneration of the spinal cord.

  4. El Concepto de Atención y Consciencia en la Obra de William James

    Directory of Open Access Journals (Sweden)

    Ana Lorena Domínguez

    2013-01-01

    Full Text Available Situar un punto inicial en la historia de la psicología para rastrear el concepto de la atención no es tarea sencilla. Esta labor indudablemente nos lleva a enfrentar viejos problemas que surgieron con la filosofía y que, con el paso de los años y de los intereses intelectuales, fueron madurando y orientándose hacia múltiples direcciones. Con el ánimo de aportar en este mapa conceptual sobre el problema de la conciencia, abordaremos la obra de un autor fundamental en esta área de estudio. El objetivo del presente texto es reconstruir parte del pensamiento de William James, especialmente sus reflexiones alrededor del concepto de atención y del campo de conciencia.

  5. Sir William Osler's perceptions of urolithiasis and the case of the indigo calculus.

    Science.gov (United States)

    Moran, Michael E; Das, Sakti; Rosenberg, Stuart A

    2005-12-01

    Sir William Osler published his textbook, The Principles and Practice of Medicine, in 1892. It became the definitive treatise on a wide variety of diseases. The section on nephrolithiasis clearly presents the etiology, pathology, symptoms, diagnosis, and treatments. What remains a mystery is the mention, under rare forms of human stones, of a type called "indigo." A search of Index Medicus starting from 1909 backward to its inception in 1879 was performed for key words "indigo," "calculus," "renal" or "bladder stones" and "indicanuria." Twelve textbooks of urology published before 1940 were scrutinized for references to indigo calculi. Only two references to indigo were found, both related to its use for treating constipation (1887 and 1891). Of the 12 textbooks, only 4 make passing reference to "indigo stones." They all mention that such calculi are very rare, but direct references to cases are lacking. One textbook references a study of blue stones from Egyptian mummies. It is unlikely that Osler's reference to an indigo calculus was taken lightly during his writing of The Principles and Practice of Medicine. The case of the indigo calculus is fascinating and perhaps enlightening if only for the source of Osler's intrigue.

  6. James Blunt matuselaulude edetabeli tipus

    Index Scriptorium Estoniae

    2006-01-01

    Bereavement Registeri andmetel Suurbritannias matustel tellitavate laulude edetabelis: James Blunt "Goodbye My Lover", Robbie Williams "Angels", Jennifer Warnes ja Bill Medley "I've Had the Time Of My Life", Elton John "Candle in the Wind", Righteous Brothers "Unchained Melody"

  7. '…to whom it will be extremly Usefull.' Dr William Cullen's adoption of James Watt's copying machine.

    Science.gov (United States)

    Wheelock, H

    2016-06-01

    Dr William Cullen (1710-1790) was a leading physician of the Enlightenment era. As professor in Edinburgh he became the most influential teacher of theoretical and practical medicine in 18th century Britain. A renowned private practitioner, Cullen systematically archived his postal 'consultations', now held by the Royal College of Physicians of Edinburgh. Initially Cullen preserved his replies as transcriptions, but from April 1781 he began using a mechanical copier, newly devised by the Scottish engineer James Watt. This paper describes the development, promotion and functioning of Watt's copier and considers Cullen's own adoption of the machine. It is suggested that with Cullen's adoption of Watt's copier, medical record keeping entered a new historical phase comparable with the recent digital revolution.

  8. The Professor and the Student, Sir Ronald Aylmer Fisher (1890-1962) and William Sealy Gosset (1876-1937): Careers of two giants in mathematical statistics.

    Science.gov (United States)

    Vyas, Shreena A; Desai, Sukumar P

    2015-05-01

    Sir Ronald Aylmer Fisher and William Sealy Gosset were responsible for laying the foundations of statistical inference. Tests that bear their names are used by students and researchers in a wide variety of scientific disciplines. Similar and different in many respects, their lives and careers are the subject of this essay. They were not teacher and pupil; in fact the student was 14 years older than the professor. Their careers did not require them to interact with one another much but they were aware of one another's work. Although Sir Ronald is assigned the role of the professor, his success as a teacher was impaired by his inability to understand the limitations of his students. Meanwhile Gosset was forced to publish his work under the pseudonym 'Student' in order to make contributions to the field of mathematical statistics. Both men are undisputed giants in the field of statistics and we celebrate their achievements as much as we try to understand their struggles. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  9. [Sir Geoffrey Keynes 1887-1982. Surgical pioneer, medical historian, humanist].

    Science.gov (United States)

    Bergljung, Lars

    2005-01-01

    Sir Geoffrey Keynes (1887 - 1982), was a pioneer in the surgery of breast cancer and thymic deseases, n.b. in patients suffering from myastenia gravis. He strongly disapproved of the longstanding dogma of so called radical mastectomy in breast cancer, and advocated a more limited surgical approach, followed by radiation therapy. This was done more than fifty years before breastconserving surgery has become the therapy of choice and against considerable opposition from the surgical establishment of his days. He also became a pioneer in the surgical treatment of myastenia gravis by thymectomy, at a time when there was no real understanding of the pathophysiology of the disease and when considerable controversy existed as to the importance or non importance of concomitant tumour formation in the thymus. Besides being a busy surgeon Sir Geoffrey was a medical historian, writing the biography of among others William Harvey, a bibliographer with a special interest in the poet and artist William Blake and a bibliophil with a large book collection of great value to medical history.

  10. William Henry Bragg, man and scientist, Nobel Laureate and First Professor of Physics, University of Adelaide 1886-1909.

    Science.gov (United States)

    Patterson, John; George, Robert

    2018-03-01

    In London, November 1915, a telegram was received at the home of William Henry Bragg from the secretary of the Academy of Science in Stockholm announcing the award of the Nobel Prize in Physics for "the analysis of crystal structures by means of X-rays". A second similar telegram was addressed to his 25 year old son William Lawrence Bragg (Jenkin, 2008). This article commemorates the centenary of that event and the unveiling of a bust of Sir William Bragg alongside that of his son, Sir Lawrence Bragg, on North Terrace in Adelaide where he spent 23 years of his early career. Copyright © 2018. Published by Elsevier Ltd.

  11. The delusion of the Master: the last days of Henry James.

    Science.gov (United States)

    Bartolomeo, Paolo

    2013-11-01

    The novelist Henry James shared with his brother William, the author of the Principles of Psychology, a deep interest in the ways in which personal identity is built through one's history and experiences. At the end of his life, Henry James suffered a vascular stroke in the right hemisphere and developed a striking identity delusion. He dictated in a perfectly clear and coherent manner two letters as if they were written by Napoleon Bonaparte. He also showed signs of reduplicative paramnesia. Negative symptoms resulting from right hemisphere damage may disrupt the feelings of "warmth and intimacy and immediacy" and the "resemblance among the parts of a continuum of feelings (especially bodily feelings)", which are the foundation of personal identity according to William James. On the other hand, a left hemisphere receiving inadequate input from the damaged right hemisphere may produce positive symptoms such as delusional, confabulatory narratives. Other fragments dictated during Henry James's final disease reveal some form of insight, if partial and disintegrated, into his condition. Thus, even when consciousness is impaired by brain damage, something of its deep nature may persist, as attested by the literary characteristics of the last fragments of the Master.

  12. OBITUARY: Sir William Mitchell Physicist and enthusiast for science

    CERN Multimedia

    Cowley, R

    2002-01-01

    "William Mitchell was successively head of Physics at Reading and Oxford universities, and Chairman of the Science and Engineering Research Council from 1985 to 1990. He is largely responsible for the excellent neutron and X-ray facilities that are available for research by scientists in the UK. He was one of the first to realise that these uniquely powerful facilities would be essential tools not only for physicists but also for chemists, biologists, materials scientists and engineers" (1 page).

  13. [Sir William Richard Gowers: author of the "bible of neurology"].

    Science.gov (United States)

    Hirose, Genjiro

    2014-11-01

    William Richard Gowers is one of the great pioneers in neurology and the author of the well-known neurology textbook, "A Manual of Diseases of the Nervous System." His concepts of neurology are based on meticulously and carefully accumulated knowledge of history, observations, and neurological examinations of patients with various neurological diseases. He is not only a great neurologist but also a great teacher who loves teaching students and physicians through well-prepared lectures. We can glean the essence of the field of neurology through his life story and numerous writings concerning neurological diseases.

  14. Do cortical midline variability and low frequency fluctuations mediate William James' "Stream of Consciousness"? "Neurophenomenal Balance Hypothesis" of "Inner Time Consciousness".

    Science.gov (United States)

    Northoff, Georg

    2014-11-01

    William James famously characterized consciousness by 'stream of consciousness' which describes the temporal continuity and flow of the contents of consciousness in our 'inner time consciousness'. More specifically he distinguished between "substantive parts", the contents of consciousness, and "transitive parts", the linkages between different contents. While much research has recently focused on the substantive parts, the neural mechanisms underlying the transitive parts and their characterization by the balance between 'sensible continuity' and 'continuous change' remain unclear. The aim of this paper is to develop so-called neuro-phenomenal hypothesis about specifically the transitive parts and their two phenomenal hallmark features, sensible continuity and continuous change in 'inner time consciousness'. Based on recent findings, I hypothesize that the cortical midline structures and their high degree of variability and strong low frequency fluctuations play an essential role in mediating the phenomenal balance between sensible continuity and continuous change. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. As novidades da psicopatologia estão no século XIX? O retorno a William James e à sua "teoria das emoções"

    Directory of Open Access Journals (Sweden)

    Guilherme Gutman

    2008-12-01

    Full Text Available O autor apresenta alguns dos principais elementos presentes na "Teoria das emoções" de William James. Entre eles, destacam-se os seguintes: 1 Inversão da ordem concebida pelo senso comum em relação à percepção subjetiva das emoções. 2 Investigação das fronteiras entre o que habitualmente se estabelece como os domínios do físico e do mental. 3 Introdução de modo preliminar das questões relacionadas a uma teoria da mente. 4 Sugestão de um novo modo de classificação para emoções, de acordo com o método pragmático.

  16. Sir William Petty: modern epidemiologist (1623-1687).

    Science.gov (United States)

    Banta, J E

    1987-01-01

    William Petty, physician, epidemiologist, political economist, demographer, cartographer, and administrator was an intellectual product of the seventeenth century. Petty was born in the year 1623 in Romsey, England of lower middle class parents; however, by the time of his death in 1687 he had become a knight of the realm, founder of the Royal Society, and friend of kings. Petty's life reflected the northern renaissance which induced such dramatic changes in science, technology, politics, and entrepreneurship. His education was eclectic, nonetheless he took his Doctor of Physic degree from Oxford in 1649 and became an Oxford don, where he spent the next few years as an academic before undertaking a definitive survey of Ireland on behalf of the Cromwell government. Ireland changed Petty's destiny and he became a man of the world and entrepreneur which stimulated his interest in public policy formulation and economics. It was Petty's peculiar genius to be innovative in the application of measurement, statistics, and mathematics to socioeconomic and demographic phenomena. As a physician he related his knowledge of health and disease to these phenomena in what in the modern context would be called human ecology or social epidemiology. These relationships and their measurement were employed to establish an objective set of data which could be analyzed for the purpose of rational public policy planning by the state. This scientific approach to public policy places Petty squarely in the context of modern epidemiologic and public health practice and marks the initiation of a major use of the epidemiologic method.

  17. Who Invented the Word Asteroid: William Herschel or Stephen Weston?

    Science.gov (United States)

    Cunningham, Clifford J.; Orchiston, Wayne

    2011-11-01

    William Herschel made the first serious study of 1 Ceres and 2 Pallas in the year 1802. He was moved by their dissimilarities to the other planets to coin a new term to distinguish them. For this purpose he enlisted the aid of his good friends William Watson and Sir Joseph Banks. Watson gave him a long list of possible names, which Herschel rejected. With a lifetime of experience classifying and naming newly found objects in nature, Banks became the man both Erasmus Darwin (in 1781) and William Herschel (in 1802) turned to for sage advice in developing a new descriptive language. In the case of Ceres and Pallas, Banks turned the task over to his friend, the noted philologist Stephen Weston, FRS. It has recently been stated by a noted British historian that it was Weston - not Herschel - who coined the term 'asteroid' to collectively describe Ceres and Pallas. This claim is investigated, and parallels are drawn in the use of neologism in astronomy and botany.

  18. Ramparts of empire the fortifications of sir william jervois, royal engineer 1821 - 1897

    CERN Document Server

    Crick, Timothy

    2015-01-01

    William Jervois was a military engineer who rose to prominence as a result of Lord Palmerston's extensive programme of fortification against a feared French invasion in the middle years of the nineteenth century. Ramparts of Empire is a detailed and engaging study of his life and works.

  19. Centennial ties: Harvey Cushing (1869-1939) and William Osler (1849-1919) on Andreas Vesalius (1514-1564).

    Science.gov (United States)

    Toodayan, Nadeem

    2017-08-01

    Andreas Vesalius is often regarded as the founding father of modern anatomical study. The quincentennial anniversary of his birth - 31 December 2014 - has been very widely commemorated, and it is the purpose of this article to contrast these celebrations with what happened during the Vesalius quatercentenary year of 1914. More specifically, we look at how Vesalius was perceived a century ago by examining his influence on two of western medicine's most iconic gentlemen - Harvey Williams Cushing (1869-1939) and his larger than life mentor, Sir William Osler (1849-1919).

  20. Estrutura e significado em "Uma rosa para Emily", de William Faulkner

    Directory of Open Access Journals (Sweden)

    Carlos Daghlian

    2004-01-01

    Full Text Available Trata-se de uma análise do consagrado conto "Uma Rosa para Emily", de William Faulkner, voltada para alguns dos principais aspectos de sua estrutura. Após considerarmos o enredo, discutimos a construção das personagens, com destaque para a protagonista, fazendo um levantamento e comentários sobre possíveis fontes de inspiração, destacando, entre outras, aspectos da biografia da poeta Emily Dickinson, a ficção e a poesia de E. A. Poe, romances de Charles Dickens e Henry James, o conto de Sherwood Anderson e a poesia de William Blake, Emily Dickinson, Robert Browning e John Crowe Ransom, acrescentando paralelos com o conto "Bartleby, o escrivão", de Herman Melville. Analisamos, então, o foco narrativo, os símbolos e o significado, ressaltando aqui o desenvolvimento temático da narrativa.This is an analysis of the well-known short story "A Rose for Emily," by William Faulkner, concentrating on some of the main aspects of its structure. A consideration of the plot is followed by a discussion of characterization, with emphasis on the protagonist, by means of a survey and comments on possible sources of inspiration including, among others, aspects of Emily Dickinson's biography, E. A. Poe's fiction and poetry, novels by Charles Dickens and Henry James, Sherwood Anderson's short stories, and the poetry of William Blake, Emily Dickinson, Robert Browning, and John Crowe Ransom, in addition to Herman Melville's short story "Bartleby, the Scrivener." The narrative focus, symbolism and meaning, stressing the thematic development of the narrative, are then analyzed.

  1. Neuroblastoma - remembering the three physicians who described it a century ago: James Homer Wright, William Pepper, and Robert Hutchison

    International Nuclear Information System (INIS)

    Rothenberg, Alexis B.; Berdon, Walter E.; D'Angio, Giulio J.; Yamashiro, Darrell J.; Cowles, Robert A.

    2009-01-01

    Neuroblastoma is often widespread at the time of diagnosis. Three physicians between 1900 and 1910 played an important role in the pathologic definition of neuroblastoma and its route of spread in relation to the age of the patient. These findings eventually led to the advances in treatment and decreased morbidity of today. In 1910 James Homer Wright was the first to recognize the tumor as being of primitive neural cell origin, calling it neuroblastoma and emphasizing the bundle of cells termed rosettes. While Wright recognized the neural nature of the tumor, the authors of previous reports had described its two distinct patterns of spread. In 1901 William Pepper published a series of infants with massive hepatic infiltration associated with adrenal tumors without spread to bone, and in 1907 Robert Grieve Hutchison reported his experience with a similar pathologic process in older infants and children who had orbital and skull metastases. Wright's valuable unifying concept served to tie together the descriptions of Pepper and Hutchison. A century later the names of these physicians should be remembered - Wright, who defined the adrenal tumor as of primitive neural origin, Pepper for his clinically accurate report of massive liver involvement in the infant, and Hutchison for describing the propensity of the tumor to spread to bone in older children. (orig.)

  2. The mitochondrial SIR2 related protein 2 (SIR2RP2 impacts Leishmania donovani growth and infectivity.

    Directory of Open Access Journals (Sweden)

    Nimisha Mittal

    2017-05-01

    Full Text Available Leishmania donovani, a protozoan parasite is the major causative agent of visceral leishmaniasis. Increased toxicity and resistance to the existing repertoire of drugs has been reported. Hence, an urgent need exists for identifying newer drugs and drug targets. Previous reports have shown sirtuins (Silent Information Regulator from kinetoplastids as promising drug targets. Leishmania species code for three SIR2 (Silent Information Regulator related proteins. Here, we for the first time report the functional characterization of SIR2 related protein 2 (SIR2RP2 of L. donovani.Recombinant L. donovani SIR2RP2 was expressed in E. coli and purified. The enzymatic functions of SIR2RP2 were determined. The subcellular localization of LdSIR2RP2 was done by constructing C-terminal GFP-tagged full-length LdSIR2RP2. Deletion mutants of LdSIR2RP2 were generated in Leishmania by double targeted gene replacement methodology. These null mutants were tested for their proliferation, virulence, cell cycle defects, mitochondrial functioning and sensitivity to known SIR2 inhibitors.Our data suggests that LdSIR2RP2 possesses NAD+-dependent ADP-ribosyltransferase activity. However, NAD+-dependent deacetylase and desuccinylase activities were not detected. The protein localises to the mitochondrion of the promastigotes. Gene deletion studies showed that ΔLdSIR2RP2 null mutants had restrictive growth phenotype associated with accumulation of cells in the G2/M phase and compromised mitochondrial functioning. The null mutants had attenuated infectivity. Deletion of LdSIR2RP2 resulted in increased sensitivity of the parasites to the known SIR2 inhibitors. The sirtuin inhibitors inhibited the ADP-ribosyltransferase activity of recombinant LdSIR2RP2. In conclusion, sirtuins could be used as potential new drug targets for visceral leishmaniasis.

  3. Tectonic geomorphology of the Andes with SIR-A and SIR-B

    Science.gov (United States)

    Bloom, Arthur L.; Fielding, Eric J.

    1986-01-01

    Data takes from SIR-A and SIR-B (Shuttle Imaging Radar) crossed all of the principal geomorphic provinces of the central Andes between 17 and 34 S latitude. In conjunction with Thematic Mapping images and photographs from hand-held cameras as well as from the Large Format Camera that was flown with SIR-B, the radar images give an excellent sampling of Andean geomorphology. In particular, the radar images show new details of volcanic rocks and landforms of late Cenozoic age in the Puna, and the exhumed surfaces of tilted blocks of Precambrian crystalline basement in the Sierras Pampeanas.

  4. Between Peirce (1878) and James (1898): G. Stanley Hall, the origins of pragmatism, and the history of psychology.

    Science.gov (United States)

    Leary, David E

    2009-01-01

    This article focuses on the 20-year gap between Charles S. Peirce's classic proposal of pragmatism in 1877-1878 and William James's equally classic call for pragmatism in 1898. It fills the gap by reviewing relevant developments in the work of Peirce and James and by introducing G. Stanley Hall, for the first time, as a figure in the history of pragmatism. In treating Hall and pragmatism, the article reveals a previously unnoted relation between the early history of pragmatism and the early history of the "new psychology" that Hall helped to pioneer. (c) 2009 Wiley Periodicals, Inc.

  5. James George Frazer’s Anthropologic Heritage in the Work of Robert Graves

    Directory of Open Access Journals (Sweden)

    Tomislav M. Pavlović

    2016-02-01

    Full Text Available The works of Sir James George Frazer had an outstanding influence on the literature of modernism. Among those who benefited from Frazer’s ritualism were W. B. Yeats, T. S. Eliot. James Joyce, Ernest Hemingway, D. H. Lawrence, Ezra Pound, Mary Renault, Joseph Campbell, Robert Graves and many others. Robert Graves was known for his famous adaptation of Frazer’s concept of the sacred king who is sacrificed for the benefit of his subjects thus forming the narrative frame for the one of his most controversial novels. The dying king is also identified with the poet striving to attain the favour of the Triple Muse Goddess - who represents the embodiment of true poetic inspiration. The aforementioned concept is not the only thing that Graves inherited from his famous ancestor. In our analysis we laid stress on the customs, rituals, magic symbols and deities both authors dealt with. We also observed a striking resemblance of the style Greves and Frazer developed and their euchemeristic approach to myths as well.

  6. One day, Sir, you may tax it

    CERN Multimedia

    2011-01-01

    “One day, Sir, you may tax it”… Those are the words I used to get the audience's attention during my talk at the World Economic Forum’s annual meeting in Davos, where I was invited to speak about the science agenda in 2011. For those of you who don’t know the quote, it was Michael Faraday’s response to William Gladstone when asked to comment on the utility of his blue-sky research into the newfangled phenomenon of electricity.   So what does a 19th century English scientist have to do with the science agenda today? A great deal, I would contend. Faraday was doing basic science, but he had the foresight to realise that through applied research his findings could one day be developed into something taxable – as it turned out, electric light. Faraday had a sense of the potential of his blue-sky research, but he also appreciated that basic science alone is not enough. This was my key message in Davos. Governments often speak of ...

  7. Análise das relações sociais entre Falstaff e os personagens femininos em peças teatrais de William Shakespeare

    Directory of Open Access Journals (Sweden)

    Daniele Gallindo Gonçalves Silva

    2016-07-01

    Full Text Available Este artigo pretende analisar e discutir a natureza do personagem Sir John Falstaff, de William Shakespeare, e de como ele dirige seus relacionamentos com as representações do feminino que o circundam, sua atitude em relação às mulheres e à honra, assim como suas preocupações com seu corpo.

  8. Ecrire et souffrir : L’inspiration partagée de Constance Fenimore Woolson et de Henry James Literature and Grief: Constance Fenimore Woolson and Henry James, A Common Inspiration

    Directory of Open Access Journals (Sweden)

    Jeannine Hayat

    2007-01-01

    Full Text Available Miss Grief is a story by Constance Fenimore Woolson, an American novelist who often wrote about the difficulty a woman had in becoming an artist — a writer or a painter — in the nineteenth century. This tale is a very strange text, a kind of anticipation of a meeting to come, in Italy, in 1880, between Woolson and Henry James, and a friendship which lasted until the former’s death in 1894. For thirteen years, both writers would share a common inspiration. Death itself could not break the links between the two authors, who were connected even when settled in different European countries. William James, who was a member of the American Society for Psychical Research, probably helped his brother Henry to communicate — or so it appears — in some way with Woolson, even after her fatal accident, or possible suicide, in Venice. Henry James probably had in mind Miss Grief, a story by his dead friend, before writing some of his books. Indeed, Woolson had been the first to develop the image of “the figure in the carpet,” which was later transformed by Henry James. Woolson was also the first to devise a plot which Henry James would later use as a canvas for his novel The Wings of the Dove. What is an author and what is authorship? It seems impossible to separate what is Woolson’s and what is Henry James’s in four works of fiction that are in fact to be read together : Miss Grief, The Figure in the Carpet, The Beast in the Jungle, The Wings of the Dove.

  9. Estrutura e significado em "Uma rosa para Emily", de William Faulkner

    OpenAIRE

    Daghlian,Carlos

    2004-01-01

    Trata-se de uma análise do consagrado conto "Uma Rosa para Emily", de William Faulkner, voltada para alguns dos principais aspectos de sua estrutura. Após considerarmos o enredo, discutimos a construção das personagens, com destaque para a protagonista, fazendo um levantamento e comentários sobre possíveis fontes de inspiração, destacando, entre outras, aspectos da biografia da poeta Emily Dickinson, a ficção e a poesia de E. A. Poe, romances de Charles Dickens e Henry James, o conto de Sherw...

  10. Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast.

    Science.gov (United States)

    Hannan, Abdul; Abraham, Neethu Maria; Goyal, Siddharth; Jamir, Imlitoshi; Priyakumar, U Deva; Mishra, Krishnaveni

    2015-12-02

    Silent information regulator 2 (Sir2), the founding member of the conserved sirtuin family of NAD(+)-dependent histone deacetylase, regulates several physiological processes including genome stability, gene silencing, metabolism and life span in yeast. Within the nucleus, Sir2 is associated with telomere clusters in the nuclear periphery and rDNA in the nucleolus and regulates gene silencing at these genomic sites. How distribution of Sir2 between telomere and rDNA is regulated is not known. Here we show that Sir2 is sumoylated and this modification modulates the intra-nuclear distribution of Sir2. We identify Siz2 as the key SUMO ligase and show that multiple lysines in Sir2 are subject to this sumoylation activity. Mutating K215 alone counteracts the inhibitory effect of Siz2 on telomeric silencing. SUMO modification of Sir2 impairs interaction with Sir4 but not Net1 and, furthermore, SUMO modified Sir2 shows predominant nucleolar localization. Our findings demonstrate that sumoylation of Sir2 modulates distribution between telomeres and rDNA and this is likely to have implications for Sir2 function in other loci as well. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  11. Sir John Macpherson, the first but sometimes overlooked Professor of Psychiatry at the University of Sydney.

    Science.gov (United States)

    White, Richard T

    2014-08-01

    To chronicle the creation of the Chair of Psychiatry at the University of Sydney, and the career and legacy, in New South Wales, of the first incumbent, Professor Sir John Macpherson CB MD FRCPE. The creation of the Chair, Macpherson's appointment, and his contributions to psychiatry in Sydney during the 52 months of his tenure, are well documented in contemporaneous sources and demonstrate that he was a very worthy Foundation Professor of Psychiatry at the University of Sydney. There are several possible reasons why Macpherson has been overlooked, including an erroneous statement in The World History of Psychiatry (1975) that William Siegfried Dawson, his successor from 1927 to 1952, was the first Professor of Psychiatry. © The Royal Australian and New Zealand College of Psychiatrists 2014.

  12. Sir William Rowan Hamilton

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 21; Issue 6 ... and in particular of mechanics, over thecenturies since Galileo and Newton, we ... and the remarkableways in which his work paved the way to theconstruction ...

  13. Sir William Rowan Hamilton

    Indian Academy of Sciences (India)

    IAS Admin

    In this picture, wave fronts are defined as surfaces of constant S(x), while .... Recall here that physical quantities are represented in ... his memory imperishable? Hamilton ... self in the words Ptolemy used of Hipparchus: a lover of labour and a ...

  14. Williams syndrome

    Science.gov (United States)

    Williams-Beuren syndrome ... Williams syndrome is caused by not having a copy of several genes. It may be passed down in families. ... history of the condition. However, people with Williams syndrome have a 50% chance of passing the disorder ...

  15. Evolution of knowledge of electricity and electrotherapeutics with special reference to x -rays and cancer

    International Nuclear Information System (INIS)

    Mould, R. F.; Aronowitz, J. N.

    2007-01-01

    The first part of this article recounting the history of electricity and electrotherapeutics closed with contribution of Charles Coulomb (1736-1806), Lurgi Galvani (1737-1798), Pierre Bertholon (1742-1800) and Jean-Paul Marat (1743-1793). This second installment continues chronologically with the story with Alessandro Volta (1745-1827) and ends with Lord Kelvin (1824-1907) and James Cleark Maxwell (1831-1879). The concluding part (to be published in 'Nowotwory' 2/2007), commences with Sir William Crookes (1832-1919) and closes with the electrotherapeutics of the early 20 th century. By then, X-ray therapy and radium brachytherapy had replaced electrotherapy as the alternative to surgery in the treatment of cancer. (author)

  16. SirR, a Novel Iron-Dependent Repressor in Staphylococcus epidermidis

    Science.gov (United States)

    Hill, Philip J.; Cockayne, Alan; Landers, Patrick; Morrissey, Julie A.; Sims, Catriona M.; Williams, Paul

    1998-01-01

    In Staphylococcus epidermidis and Staphylococcus aureus, a number of cell wall- and cytoplasmic membrane-associated lipoproteins are induced in response to iron starvation. To gain insights into the molecular basis of iron-dependent gene regulation in the staphylococci, we sequenced the DNA upstream of the 3-kb S. epidermidis sitABC operon, which Northern blot analysis indicates is transcriptionally regulated by the growth medium iron content. We identified two DNA sequences which are homologous to elements of the Corynebacterium diphtheriae DtxR regulon, which controls, in response to iron stress, for example, production of diphtheria toxin, siderophore, and a heme oxygenase. Upstream of the sitABC operon and divergently transcribed lies a 645-bp open reading frame (ORF), which codes for a polypeptide of approximately 25 kDa with homology to the DtxR family of metal-dependent repressor proteins. This ORF has been designated SirR (staphylococcal iron regulator repressor). Within the sitABC promoter/operator region, we also located a region of dyad symmetry overlapping the transcriptional start of sitABC which shows high homology to the DtxR operator consensus sequence, suggesting that this region, termed the Sir box, is the SirR-binding site. The SirR protein was overexpressed, purified, and used in DNA mobility shift assays; SirR retarded the migration of a synthetic oligonucleotide based on the Sir box in a metal (Fe2+ or Mn2+)-dependent manner, providing confirmatory evidence that this motif is the SirR-binding site. Furthermore, Southern blot analysis of staphylococcal chromosomal DNA with the synthetic Sir box as a probe confirmed that there are at least five Sir boxes in the S. epidermidis genome and at least three in the genome of S. aureus, suggesting that SirR controls the expression of multiple target genes. Using a monospecific polyclonal antibody raised against SirR to probe Western blots of whole-cell lysates of S. aureus, S. carnosus, S. epidermidis

  17. A Novel Method of SIR Measurement for Power Control in CDMA Systems

    International Nuclear Information System (INIS)

    Yu, J; Wu, S B; He, J Z

    2006-01-01

    CDMA is interference limited multiple access system. Power control is an effective way to reduce co-channel interference and solve the near-far problem. Consequently, it can improve the system capacity, and make higher data rate possible. CDMA2000 employs fast closed-loop power control in reverse link to combat channel fading, and the estimation of signal to interference ratio (SIR) is required for closed-loop power control. Transmitting power is adjusted by comparing the SIR estimation with SIR target. So, it is crucial to measure the SIR of received signal accurately. Traditional measurement methods mostly depend on pilot signal strongly, when the pilots are few, there is a greater error brought to the measurement of SIR. In this paper, we discuss the SIR measurement of the received signal under the fewer pilots condition (especially only one pilot symbol) and present a novel SIR measurement method. According to the simulation, the numerical results indicate that the SIR measured by the proposed method is more accurate than the SIR measured by conventional method under fewer pilots condition

  18. Sense data and the philosophy of mind: Russell, James, and Mach

    Directory of Open Access Journals (Sweden)

    Gary Hatfield

    2002-12-01

    Full Text Available The theory of knowledge in early twentieth-century Anglo American philosophy was oriented toward phenomenally described cognition There was a healthy respect for the mind body problem, which meant that phenomena in both the mental and physical domain were taken sinuously Bertrand Russell's developing position on sense-data and momentary particulars drew upon, and ultimately became like, the neutral monism of Ernst Mach and William James Due to a more recent behaviorist and physicalist inspired "fear of the mental", this development has been down played in historical work on early analytic philosophy Such neglect as sumes that the "linguistic turn" is a proper and permanent effect of twentieth century philosophy, an assumption that distorts early analytic historiography, and begs a substantive philosophical question about thought and cognition.

  19. First measurement of 153Sm in the SIR

    International Nuclear Information System (INIS)

    Michotte, C.; Ratel, G.; Lucas, L.

    1999-01-01

    In June 1998, the NIST sent to the International Reference System (SIR) a solution of 153 Sm standardized in a 4π ionization chamber. As this radionuclide had not previously been measured in the SIR, the resulting equivalent activity A e,NIST is compared with the value calculated from the efficiency curve of the SIR. However, problems occurred owing to the presence of 154 Eu and 156 Eu impurities in the solution. The manner in which the final equivalent activity value for this solution of 153 Sm has been deduced is described in this report. (authors)

  20. Sir Kenelm Digby (1603-1665): diplomat, entrepreneur, privateer, duellist, scientist and philosopher.

    Science.gov (United States)

    Mellick, Sam A

    2011-12-01

    Kenelm Digby was a man with widely differing interests. He studied at Oxford but left without a degree. At the age of 20, he was involved in a dramatic street brawl in Madrid; the following year saw him as a successful privateer in the Mediterranean and adjacent Atlantic waters, and he was then appointed a naval administrator with lucrative trade monopolies. He practised medicine without formal qualifications and gained notoriety by promoting the use of 'sympathetic' powder for healing wounds. Befriended by King James I and his son who succeeded him, he became chancellor to Queen Henrietta and was knighted by King James I on 21 October 1623 and appointed to the Privy Council. At one time, he even spent a brief time in prison, but he later became a founding member of the Royal Society and published two major philosophical treatises as well as a popular cookbook. He designed and manufactured wine bottles with tapered necks for simpler pouring and square sides for easy stacking. He dabbled in mathematics and corresponded with Fermat of 'Last Theorem' fame. In 1641, he challenged a French nobleman who publicly cast a slur on the British King to a 'digladiation' (a sword duel) and quickly dispatched him. He was a friend and admirer of Sir Thomas Browne whose 'Religio Medici' he helped to publish. The Cowlishaw Library holds a 1659 5th edition copy of this remarkable book, with Digby's name on the spine. Truly, Digby must qualify as a Renaissance man. © 2011 The Author. ANZ Journal of Surgery © 2011 Royal Australasian College of Surgeons.

  1. Lymphocyte integrin expression differences between SIRS and sepsis patients.

    Science.gov (United States)

    Heffernan, D S; Monaghan, S F; Ayala, Alfred

    2017-11-01

    Systemic Inflammatory Response Syndrome (SIRS) and sepsis remain leading causes of death. Despite many similarities, the two entities are very distinct clinically and immunologically. T-Lymphocytes play a key pivotal role in the pathogenesis and ultimately outcome following both SIRS and sepsis. Integrins are essential in the trafficking and migration of lymphocytes. They also serve vital roles in efficient wound healing and clearance of infections. Here, we investigate whether integrin expression, specifically β1 (CD29) and β2 (CD18), are disrupted in SIRS and sepsis, and assess differences in integrin expression between these two critically ill clinical categories. T-Lymphocytes were isolated from whole blood collected from ICU patients exhibiting SIRS or sepsis. Samples were analyzed for CD18 (β2) and CD29 (β1) on CD3 + T cells through flow cytometry. Septic patients were stratified into either exclusively abdominal or non-abdominal sources of sepsis. CD18 was almost ubiquitously expressed on CD3 + T cells irrespective of clinical condition. However, CD29 (β1 integrin) was lowest in SIRS patients (20.4% of CD3 + T cells) when compared with either septic patients (35.5%) or healthy volunteers (54.1%). Furthermore, there was evidence of compartmentalization in septic patients, where abdominal sources had a greater percentage of CD3 + CD29 + T cells (41.7%) when compared with those with non-abdominal sources (29.5%). Distinct differences in T-cell integrin expression exists between patients in SIRS versus sepsis, as well as relative to the source of sepsis. Further work is needed to understand cause and effect relative to the progression from SIRS into sepsis.

  2. Validation of the Spanish SIRS with monolingual Hispanic outpatients.

    Science.gov (United States)

    Correa, Amor A; Rogers, Richard; Hoersting, Raquel

    2010-09-01

    Psychologists are faced with formidable challenges in making their assessment methods relevant to growing numbers of Hispanic clients for whom English is not the primary or preferred language. Among other clinical issues, the determination of malingering has profound consequences for clients. In this investigation, we evaluated a Spanish translation of the Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1992) with 80 Spanish-speaking Hispanic American outpatients. Using a between-subjects simulation design, the Spanish SIRS was found to produce reliable results with small standard errors of measurement. Regarding validity, very large effect sizes (mean Cohen's d= 2.00) were observed between feigners and honest responders for the SIRS primary scales. We consider the potential role of the Spanish SIRS with reference to Spanish translations for other assessment instruments.

  3. The Systemic Inflammatory Response Syndrome (SIRS in acutely hospitalised medical patients: a cohort study

    Directory of Open Access Journals (Sweden)

    Storgaard Merete

    2009-12-01

    Full Text Available Abstract Background Sepsis is an infection which has evoked a systemic inflammatory response. Clinically, the Systemic Inflammatory Response Syndrome (SIRS is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in medical emergency ward patients is unknown. Methods We conducted a prospective cohort study of the frequency of SIRS and its relationship to sepsis and death among acutely hospitalised medical patients. In 437 consecutive patients, SIRS status, blood pressure, infection and comorbidity on admission was registered together with 28-day mortality. Results A hundred and fifty-four patients (35% had SIRS on admission, 211 patients (48% had no SIRS, and 72 patients (16% had insufficient data to evaluate their SIRS status. SIRS patients were 2.2 times more frequently infected, with 66/154 SIRS patients versus 41/211 non-SIRS patients: p Conclusion We found SIRS status on admission to be moderately associated with infection and strongly related to 28-day mortality.

  4. 33 CFR 167.1702 - In Prince William Sound: Prince William Sound Traffic Separation Scheme.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false In Prince William Sound: Prince William Sound Traffic Separation Scheme. 167.1702 Section 167.1702 Navigation and Navigable Waters COAST....1702 In Prince William Sound: Prince William Sound Traffic Separation Scheme. The Prince William Sound...

  5. William Henry Broadbent (1835-1907) as a neurologist.

    Science.gov (United States)

    Eadie, Mervyn

    2015-01-01

    By the end of his career, Sir William Broadbent (1835-1907) had become an eminent London general physician who had been appointed Physician-in-Ordinary to King Edward VII and to the Prince of Wales. Previously he had been Physician-in-Extraordinary to Queen Victoria. At earlier stages in his professional life, he had played a significant role in the development of clinical neurology in Victorian-era Britain. In 1866, he had enunciated a principle (Broadbent's hypothesis) that for the first time satisfactorily accounted for the mechanisms by which the trunk and bulbar muscles and the upper face were spared in hemiplegia. He had also carried out original investigations into the distribution of fiber tracts in the human cerebral hemispheres. At intervals over the years, he published on aspects of aphasia and developed a rather complicated though logical conceptual schema of the presumed anatomical background to the process of speech, based on clinic-pathological correlations. His role in all this neurological research and his other contributions on subjects such as neurosyphilis have largely been forgotten by subsequent generations.

  6. [Williams-Beuren syndrome (Williams syndrome). Case report].

    Science.gov (United States)

    Miklós, Györgyi; Fekete, György; Haltrich, Irén; Tóth, Miklós; Reismann, Péter

    2017-11-01

    Williams syndrome is a rare genetic disorder, that occurs equally in all ethnic groups and both sexes. The diagnosis might be missed during childhood in mild cases. However, establishing the diagnosis is important, not only to find the cause of intellectual disability but to look for cardiovascular, endocrine, psychiatry, urology and other conditions, which can occur at any age in the patients' lifetime. This case report presents the story of 47-year-old woman, who was admitted with haematemesis. During her stay on the ward, in the light of the distinctive facial features, mental retardation, and social behaviour patterns, the possibility of Williams syndrome emerged. Later, the diagnosis was confirmed by genetic analysis. This female is the oldest living patient with Williams syndrome in Hungary. Orv Hetil. 2017; 158(47): 1883-1888.

  7. [Sir Humphry Davy, the discoverer of anesthetic action of nitrous oxide--Davy and poets of British Romanticism and inhalation of laughing gas by his friends].

    Science.gov (United States)

    Fujita, T

    1998-01-01

    In "Dove Cottage", the old house of the poet laureate William Wordsworth (1770-1850) in Grasmere, England, there is a portrait of Sir Humphry Davy (1778-1829). In 1804, Wordsworth invited his young friend to his home. Davy's works in the field of chemistry are well known. Interestingly enough, once he wished he could be a poet. His future seemed to be prosperous and delightful. He was highly evaluated by Robert Southey, poet laureate. But he has chosen the way of chemist. The author found some facts from literatures and received some information by courtesy of the Wordsworth Trust, Centre for British Romanticism. Davy's life and his works were introduced chronologically.

  8. Ebenezer Hopkins Frost (1824-1866): William T.G. Morton's first identified patient and why he was invited to the Ether demonstration of October 16, 1846.

    Science.gov (United States)

    LeVasseur, Ryan; Desai, Sukumar P

    2012-08-01

    Although he was not the first to use ether as an anesthetic, it was not until William Thomas Green Morton's demonstration of the efficacy of ether anesthesia that its use spread rapidly throughout the world. Full identities of the first anesthetized patients of William Edward Clarke and Horace Wells are not known, but we are quite certain that Crawford Williamson Long correctly identified James Venable as his first patient to receive anesthesia. Using municipal records, historical accounts, and recent analyses of Morton's unsavory side, we undertook this study to explore three questions. First, we examine how Morton refined the technique of administering anesthesia based on Wells' failed attempt. Second, we describe the circumstances under which Morton encountered his first patient to receive anesthesia. Third, we offer an explanation as to why Morton insisted on bringing along this patient to attend the grand event we celebrate as Ether Day. This is an essay about William Thomas Green Morton and Ebenezer Hopkins Frost.

  9. SirT1 regulates energy metabolism and response to caloric restriction in mice.

    Directory of Open Access Journals (Sweden)

    Gino Boily

    Full Text Available The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utilize ingested food. These mice are hypermetabolic, contain inefficient liver mitochondria, and have elevated rates of lipid oxidation. When challenged with a 40% reduction in caloric intake, normal mice maintained their metabolic rate and increased their physical activity while the metabolic rate of SirT1-null mice dropped and their activity did not increase. Moreover, CR did not extend lifespan of SirT1-null mice. Thus, SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction.

  10. 33 CFR 147.817 - Sir Douglas Morpeth Tension Leg Platform safety zone.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Sir Douglas Morpeth Tension Leg... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.817 Sir Douglas Morpeth Tension Leg Platform safety zone. (a) Description. The Sir Douglas Morpeth Tension Leg Platform (Morpeth...

  11. New Processing of Spaceborne Imaging Radar-C (SIR-C) Data

    Science.gov (United States)

    Meyer, F. J.; Gracheva, V.; Arko, S. A.; Labelle-Hamer, A. L.

    2017-12-01

    The Spaceborne Imaging Radar-C (SIR-C) was a radar system, which successfully operated on two separate shuttle missions in April and October 1994. During these two missions, a total of 143 hours of radar data were recorded. SIR-C was the first multifrequency and polarimetric spaceborne radar system, operating in dual frequency (L- and C- band) and with quad-polarization. SIR-C had a variety of different operating modes, which are innovative even from today's point of view. Depending on the mode, it was possible to acquire data with different polarizations and carrier frequency combinations. Additionally, different swaths and bandwidths could be used during the data collection and it was possible to receive data with two antennas in the along-track direction.The United States Geological Survey (USGS) distributes the synthetic aperture radar (SAR) images as single-look complex (SLC) and multi-look complex (MLC) products. Unfortunately, since June 2005 the SIR-C processor has been inoperable and not repairable. All acquired SLC and MLC images were processed with a course resolution of 100 m with the goal of generating a quick look. These images are however not well suited for scientific analysis. Only a small percentage of the acquired data has been processed as full resolution SAR images and the unprocessed high resolution data cannot be processed any more at the moment.At the Alaska Satellite Facility (ASF) a new processor was developed to process binary SIR-C data to full resolution SAR images. ASF is planning to process the entire recoverable SIR-C archive to full resolution SLCs, MLCs and high resolution geocoded image products. ASF will make these products available to the science community through their existing data archiving and distribution system.The final paper will describe the new processor and analyze the challenges of reprocessing the SIR-C data.

  12. Development of SIR-C Ground Calibration Equipment

    Science.gov (United States)

    Freeman, A.; Azeem, M.; Haub, D.; Sarabandi, K.

    1993-01-01

    SIR-C/X-SAR is currently scheduled for launch in April 1994. SIR-C is an L-Band and C-Band, multi-polarization spaceborne SAR system developed by NASA/JPL. X- SAR is an X-Band SAR system developed by DARA/ASI. One of the problems involved in calibrating the SIR-C instrument is to make sure that the horizontal (H) and vertical (V) polarized beams are aligned in the azimuth direction, i.e.. that they are pointing in the same direction. This is important if the polarimetric performance specifications for the system are to be met. To solve this problem, we have designed and built a prototype of a low-cost ground receiver capable of recording received power from two antennas, one H-polarized, the other V-polarized. The two signals are mixed to audio then recorded on the left and right stereo channels of a standard audio cassette player. The audio cassette recording can then be played back directly into a Macintosh computer, where it is digitized. Analysis of.

  13. Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.

    Science.gov (United States)

    Gallo, Christopher M; Smith, Daniel L; Smith, Jeffrey S

    2004-02-01

    The Saccharomyces cerevisiae Sir2 protein is an NAD(+)-dependent histone deacetylase (HDAC) that functions in transcriptional silencing and longevity. The NAD(+) salvage pathway protein, Npt1, regulates Sir2-mediated processes by maintaining a sufficiently high intracellular NAD(+) concentration. However, another NAD(+) salvage pathway component, Pnc1, modulates silencing independently of the NAD(+) concentration. Nicotinamide (NAM) is a by-product of the Sir2 deacetylase reaction and is a natural Sir2 inhibitor. Pnc1 is a nicotinamidase that converts NAM to nicotinic acid. Here we show that recombinant Pnc1 stimulates Sir2 HDAC activity in vitro by preventing the accumulation of NAM produced by Sir2. In vivo, telomeric, rDNA, and HM silencing are differentially sensitive to inhibition by NAM. Furthermore, PNC1 overexpression suppresses the inhibitory effect of exogenously added NAM on silencing, life span, and Hst1-mediated transcriptional repression. Finally, we show that stress suppresses the inhibitory effect of NAM through the induction of PNC1 expression. Pnc1, therefore, positively regulates Sir2-mediated silencing and longevity by preventing the accumulation of intracellular NAM during times of stress.

  14. Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states.

    Directory of Open Access Journals (Sweden)

    Stephanie Kueng

    Full Text Available Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM loci in budding yeast. We have performed a detailed biochemical and genetic analysis of the largest Sir protein, Sir4. The N-terminal half of Sir4 is dispensable for SIR-mediated repression of HM loci in vivo, except in strains that lack Yku70 or have weak silencer elements. For HM silencing in these cells, the C-terminal domain (Sir4C, residues 747-1,358 must be complemented with an N-terminal domain (Sir4N; residues 1-270, expressed either independently or as a fusion with Sir4C. Nonetheless, recombinant Sir4C can form a complex with Sir2 and Sir3 in vitro, is catalytically active, and has sedimentation properties similar to a full-length Sir4-containing SIR complex. Sir4C-containing SIR complexes bind nucleosomal arrays and protect linker DNA from nucleolytic digestion, but less effectively than wild-type SIR complexes. Consistently, full-length Sir4 is required for the complete repression of subtelomeric genes. Supporting the notion that the Sir4 N-terminus is a regulatory domain, we find it extensively phosphorylated on cyclin-dependent kinase consensus sites, some being hyperphosphorylated during mitosis. Mutation of two major phosphoacceptor sites (S63 and S84 derepresses natural subtelomeric genes when combined with a serendipitous mutation (P2A, which alone can enhance the stability of either the repressed or active state. The triple mutation confers resistance to rapamycin-induced stress and a loss of subtelomeric repression. We conclude that the Sir4 N-terminus plays two roles in SIR-mediated silencing: it contributes to epigenetic repression by stabilizing the SIR-mediated protection of linker DNA; and, as a target of phosphorylation, it can destabilize silencing in a regulated manner.

  15. SIR-ZEE: plataforma tecnológica para el desarrollo local SIR-ZEE: technology platform for local development

    Directory of Open Access Journals (Sweden)

    Marlen Treviño Villalobos

    2012-11-01

    Full Text Available El Sistema de Información Regional de la Zona Económica Especial (SIR-ZEE nació en Costa Rica aproximadamente en 1998, cuando se concibió la idea de crear un sistema informático para recopilar, gestionar y ofrecer temáticas generadas en forma digital por diferentes entidades públicas y privadas. En el 2008, con los fondos del Programa de Regionalización Interuniversitaria del Consejo Nacional de Rectores, se aprobó la iniciativa SIR-ZEE, Plataforma Tecnológica para el Desarrollo Local, que buscó fortalecer las capacidades productivas y las capacidades de gobernabilidad en la Región Huetar Norte mediante el acceso a la información oportuna y relevante para el desarrollo económico local. Este artículo tiene como objetivo mostrar no solo la relevancia de un sistema de información en la planificación del desarrollo local, sino también que, en la actualidad, el SIR-ZEE se está convirtiendo en una ventaja competitiva para la Región Huetar Norte, ya que facilita el proceso de toma decisiones. Los principales resultados obtenidos al final de la iniciativa fueron una propuesta metodológica para la elaboración de planes estratégicos de desarrollo local en la Región Huetar Norte, la sensibilización de los actores locales sobre la participación ciudadana en las diferentes fases de la planificación, un diagnóstico territorial con el valor agregado de contar con la información georreferenciada y disponible en un sitio web, y avances en la elaboración del Plan estratégico de desarrollo local.The Regional Information System of the Special Economic Zone (SIR-ZEE was born about the year 1998 as a computer system to collect, manage and offer thematic generated in digital format by different public and private entities. In 2008, with the funds of Interuniversity Regionalization Program the National Council of Rectors approved the initiative SIR- ZEE: Platform Technology for Local Development which sought to strengthen productive

  16. An interview with James Briscoe.

    Science.gov (United States)

    Brown, Katherine

    2018-03-27

    James Briscoe is a group leader at The Francis Crick Institute in London. His lab's research focusses on the developing vertebrate spinal cord, with a particular interest in how sonic hedgehog gradients, and the downstream signal transduction and transcriptional networks, regulate the development of this tissue. In September 2018, James will become the new Editor-in-Chief of Development. We met with James to discuss his career and research interests, the importance of interdisciplinary thinking in developmental biology, and his views on the current state and future opportunities in scientific publishing. © 2018. Published by The Company of Biologists Ltd.

  17. Geim, Prof. Sir Andre Konstantin

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...

  18. Sir John Meurig Thomas.

    Science.gov (United States)

    Thomas, John Meurig

    2013-10-11

    "My greatest achievement has been to combine being a teacher, a researcher, and a popularizer of science for over 50 years. My worst nightmare is to find myself dumbstruck when I am about to give a lecture …︁" This and more about Sir John Meurig Thomas can be found on page 10938. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. St. James marine terminal facility description

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    The US Department of Energy (DOE) currently owns and operates a marine terminal on the west bank of the Mississippi River at St. James, Louisiana. The St. James facility was constructed by the Department to provide marine services associated with the fill and drawdown of the Strategic Petroleum Reserve (SPR) crude oil storage facilities located at Bayou Choctaw and Weeks Island, Louisiana. Although strategic to the mission of the SPR in the event of a national emergency, the St. James terminal is situated such that it has a high potential to also serve the commercial industry`s needs for crude oil terminalling and storage. The St. James terminal is located approximately 45 miles west of New Orleans and 30 miles southeast of Baton Rouge, and approximately 160 miles upstream from the mouth of the Mississippi River. Construction of the St. James terminal was initiated in 1978 and was completed in 1980. Since then, the terminal has received and transferred over 125 million barrels of crude oil to the SPR sites for storage. For crude oil distribution, the St. James terminal was connected to the neighboring LOCAP terminal by a 0.1 mile 36-inch pipeline in 1981 and to the Capline terminal by a 0.5 mile 30-inch pipeline in 1988. The terminal also has a 30-inch pipeline connection to the Koch oil terminal which was used for initial fill purposes; however, this pipeline has been disconnected and is currently inactive. A complete description of the St. James terminal facilities, operational capabilities, operational certifications, and future Government requirements are presented in Sections 2, 3, 4, and 5 respectively.

  20. Sir Karl Popper and Education

    Science.gov (United States)

    McNamara, D. R.

    1978-01-01

    Sir Karl Popper is one of England's most distinguished contemporary philosophers and it is surprising that his thought has not permeated and informed educational discussion. This paper suggests that educationists have much to learn from Karl Popper's writings and explores ways in which his ideas can illuminate and advance discussion about…

  1. Thomas, Prof. Sir John Meurig

    Indian Academy of Sciences (India)

    Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage ... Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more.

  2. Constitutive Relation of Engineering Material Based on SIR Model and HAM

    Directory of Open Access Journals (Sweden)

    Haoxiang He

    2014-01-01

    Full Text Available As an epidemic mathematical model, the SIR model represents the transition of the Susceptible, Infected, and Recovered. The profound implication of the SIR model is viewed as the propagation and dynamic evolutionary process of the different internal components and the characteristics in a complex system subject to external effect. The uniaxial stress-strain curve of engineering material represents the basic constitutive relation, which also represents the damage propagation in the units of the damaged member. Hence, a novel dynamic stress-strain model is established based on the SIR model. The analytical solution and the approximate solution for the proposed model are represented according to the homotopy analysis method (HAM, and the relationship of the solution and the size effect and the strain rate is discussed. In addition, an experiment on the size effect of confined concrete is carried out and the solution of SIR model is suitable for simulation. The results show that the mechanical mechanism of the parameters of the uniaxial stress-strain model proposed in this paper reflects the actual characteristics of the materials. The solution of the SIR model can fully and accurately show the change of the mechanical performance and the influence of the size effect and the strain rate.

  3. James Bernoulli与《推测术》%James Bernoulli and Stochastics

    Institute of Scientific and Technical Information of China (English)

    于忠义

    2003-01-01

    Two hundred and eighty-nine years ago, "Arts of conjecturing", the posthumous work of the great mathematician James Bernoulli, was finally produced in the eager wait of mathematicians, Ian Hacking, a famous historian of statistics, commented that the publication of the book signaled the beginning of the mathematical theory of probability and terminated man's long process in the forming of the probability concept By introducing James Bernoulli and his "Arts of conjecturing", this paper aims at providing the reader with the 18th century story of Bemoulli's work, and at making the reader know that even today Bemoulli's idea is very helpful and instructive in the research of modern statistics.

  4. Productive Second elements in nominal compounds: the matching of Englis and German

    Directory of Open Access Journals (Sweden)

    Otto Hietsch

    1984-12-01

    Full Text Available Amongst the treasured reminders of my postgraduate years in England, I cherish a sizable sheaf of manuscript pages, now yellow with age. They are in the hand of Sir William Craigie, that venerable pioneer of lexicographical study. The neat and delicate lines trace out the beginnings of a new venture. Sir William was making a record of the nominal compounds in Beowulf: they are arrayed under the banners of various headwords, each of which, as a glance will show, is a   s e c o n d element of composition. Alas, work on the project was never completed, nor are the present generation of Anglo-Saxonists aware of the particular line of argument Sir William had in mind when he set out to re-list the Beowulf compound vocabu­ lary.

  5. Scientific objectives and selection of targets for the SMART-1 Infrared Spectrometer (SIR)

    Science.gov (United States)

    Basilevsky, A. T.; Keller, H. U.; Nathues, A.; Mall, U.; Hiesinger, H.; Rosiek, M.

    2004-12-01

    The European SMART-1 mission to the Moon, primarily a testbed for innovative technologies, was launched in September 2003 and will reach the Moon in 2005. On board are several scientific instruments, including the point-spectrometer SMART-1 Infrared Spectrometer (SIR). Taking into account the capabilities of the SMART-1 mission and the SIR instrument in particular, as well as the open questions in lunar science, a selection of targets for SIR observations has been compiled. SIR can address at least five topics: (1) Surface/regolith processes; (2) Lunar volcanism; (3) Lunar crust structure; (4) Search for spectral signatures of ices at the lunar poles; and (5) Ground truth and study of geometric effects on the spectral shape. For each topic we will discuss specific observation modes, necessary to achieve our scientific goals. The majority of SIR targets will be observed in the nadir-tracking mode. More than 100 targets, which require off-nadir pointing and off-nadir tracking, are planned. It is expected that results of SIR observations will significantly increase our understanding of the Moon. Since the exact arrival date and the orbital parameters of the SMART-1 spacecraft are not known yet, a more detailed planning of the scientific observations will follow in the near future.

  6. King, Prof. Sir David Anthony

    Indian Academy of Sciences (India)

    Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.

  7. Intervjuu James Corneriga = Interview with James Corner / James Corner ; interv. Andres Sevtshuk

    Index Scriptorium Estoniae

    Corner, James

    2006-01-01

    Büroo Field Operations maastikuarhitekt ning Pennsylvania Ülikooli maastikuarhitektuuri osakonna juhataja James Corner oma büroost, maastikust kui "instrumendist", postindustriaalsete aladega seotud projektidest (New Yorgi High Line'i muutmine pargiks ja promenaadiks), tööst suuremahuliste maastikega (Fresh Kills'i soo, endise prügila muutmine pargialaks), maastikuarhitektuurist ja linnakujundusest (maastiku urbanism), õpetamise tähtsusest oma töös ja maastikuarhitektuuri ideede arendamisel. Bibl. lk. 24

  8. 90Sr content in 90Y-labeled SIR-spheres and Zevalin.

    Science.gov (United States)

    Metyko, John; Erwin, William; Poston, John; Jimenez, Sandra

    2014-11-01

    Three different 90Y internally administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures atMD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize 90Y-labeled microspheres, while Zevalin is an 90Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from 90Y production methods. The 90Y in SIR-Spheres and Zevalin are produced from a 90Sr/90Y generator, which leaves measurable quantities of 90Sr in the final product. TheraSphere 90Y is produced in a nuclear reactor which results in a large number of impurities, most notably 88Y and 91Y. Product information sheets reference these impurities with specific limits given. These limits represent a tiny fraction of the total product activity, and in the case of TheraSphere and SIR-Spheres gamma-emitting impurities, this has been verified in the literature. An analysis of 90Sr impurities in SIR-Spheres and Zevalin is presented in this paper. Impurity quantities were found to be within the vendors’ documented limits.

  9. James Stevens / James Stevens ; interv. Tilman Baumgärtel

    Index Scriptorium Estoniae

    Stevens, James

    2006-01-01

    Inglise disainerist James Stevensist (sünd. 1962) ja tema tegevusest. J. Stevens 2000. a. Amsterdamis tehtud intervjuus koos Jon Bainsi ja Kim Bulliga 1995. a. Londonis avatud Interneti-agentuurist Obsolete, 1996-2000 tegutsenud Interneti-kohvikust Backspace, mittekommertsiaalse juhtmeteta nerworki Consume.net rajamisest Londonis

  10. James Gillies

    CERN Multimedia

    2008-01-01

    "Physicist James gillies is chief of communications at CERN (the European Organisation for Nuclear Research). Based in the Jura foothills, just outside Geneva, Gillies is part of a teamt hat will fire up CERN's Large Hadron Collierd (LHC) - the most complicated piece of scientific equipment ever built." (1/2 page)

  11. Poor and Rich in James: A Relevance Theory Approach to James's Use of the Old Testament

    Science.gov (United States)

    Morales, Nelson R.

    2015-01-01

    The epistle of James was for years a forgotten book in academic circles. In recent decades, however, a renewed focus on early Judaism has generated interest in looking at James with new eyes. Poverty and wealth in the epistle continues to be a point of interest. Other topics, however, are still to be explored. One of these topics is the rhetorical…

  12. SIRS Digues 2.0: A Cooperative Software For Levees Management

    Directory of Open Access Journals (Sweden)

    Moins Isabelle

    2016-01-01

    Full Text Available SIRS Digues is a computing tool that makes informations on levees more durable and accessible in order to enhance their management. The first version of the software, which was IRSTEA’s initiative, was deployed in 2004. The second version was released in 2015. This article aims at pointing out the innovative aspects of this last version. They concern thematic and functionalities, computing technics and architecture, and last but not least, the business model chosen in order to build a long lasting software. The software’s kernel is sketched to propose a general description of levees: it focuses on description of the levees and linked objects, on disorders that affects them, on works... Most of these topics were already broached by the first version. The kernel of the version 2 may be extended using optional thematic modules. These modules concern: vegetation monitoring, reporting (in coherence with current French regulatory requirements, riverbanks, riverbed... Main functionnalities perfomed by SIRS Digues V1 and V2 are : data structuring and centralisation, quick access to relevant data, reporting and mapping, etc. SIRS Digues 2.0 updates and improves already existing functionalities of the first version. SIRS Digues V2 relies on an documentoriented NoSQL database, CouchDB, and on geospatial libraries, Geotoolkit and Apache-SIS. SIRS Digues V2 was released with a copyleft license. Copyrights belong to the French levees managers’ society, “France Digues”, which acts as a cooperative. Members put their heads together in order to gather their financial capacities and fund software development. France Digues has got the technical and thematic expertise and supply various services to the members. This business model aims to ensure accessibility, durability and adaptability of the software.

  13. Coal Age Galapogos: Joggins and the lions of nineteenth century geology

    Energy Technology Data Exchange (ETDEWEB)

    Calder, J.H. [Nova Scotia Department of Natural Resources, Halifax, NS (Canada)

    2006-07-01

    Since the 1870s, the Joggins coastal section has been recognized as an outstanding section of Carboniferous strata. Accounts about the geology of the Joggins area first appeared in the published literature in 1828. Early history, visits by Sir Charles Lyell and Sir William Logan in 1842 and later, early Geological Survey of Canada field projects, tree trunk fauna, O.C. Marsh's fossil discoveries, Lyell, Dawson and Darwin on evolution, the origin of coal, and discoveries by Sir William Dawson are discussed. The Joggins coastal section has been placed on Canada's Tentative List of future World Heritage Site nominees. 71 refs., 18 figs.

  14. Raymond Williams and local cultures

    OpenAIRE

    B Longhurst

    1991-01-01

    In this paper it is maintained that Raymond Williams's writings on culture are of great importance to current developments in cultural geography. His work is periodised into three stages and its different subject matters identified. An interpretation of Williams's theory of culture is offered which places particular emphasis on his concepts of 'structure of feeling' and 'knowable community'. The creative tension between Williams's holistic treatment of culture and his stress on cultural strug...

  15. C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.

    Science.gov (United States)

    Chiang, Wei-Chung; Tishkoff, Daniel X; Yang, Bo; Wilson-Grady, Joshua; Yu, Xiaokun; Mazer, Travis; Eckersdorff, Mark; Gygi, Steven P; Lombard, David B; Hsu, Ao-Lin

    2012-09-01

    FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4--homolog of mammalian SIRT6 and SIRT7 proteins--promotes DAF-16-dependent transcription and stress-induced DAF-16 nuclear localization. SIR-2.4 is required for resistance to multiple stressors: heat shock, oxidative insult, and proteotoxicity. By contrast, SIR-2.4 is largely dispensable for DAF-16 nuclear localization and function in response to reduced insulin/IGF-1-like signaling. Although acetylation is known to regulate localization and activity of mammalian FoxO proteins, this modification has not been previously described on DAF-16. We find that DAF-16 is hyperacetylated in sir-2.4 mutants. Conversely, DAF-16 is acetylated by the acetyltransferase CBP-1, and DAF-16 is hypoacetylated and constitutively nuclear in response to cbp-1 inhibition. Surprisingly, a SIR-2.4 catalytic mutant efficiently rescues the DAF-16 localization defect in sir-2.4 null animals. Acetylation of DAF-16 by CBP-1 in vitro is inhibited by either wild-type or mutant SIR-2.4, suggesting that SIR-2.4 regulates DAF-16 acetylation indirectly, by preventing CBP-1-mediated acetylation under stress conditions. Taken together, our results identify SIR-2.4 as a critical regulator of DAF-16 specifically in the context of stress responses. Furthermore, they reveal a novel role for acetylation, modulated by the antagonistic activities of CBP-1 and SIR-2.4, in modulating DAF-16 localization and function.

  16. Totally James

    Science.gov (United States)

    Owens, Tom

    2006-01-01

    This article presents an interview with James Howe, author of "The Misfits" and "Totally Joe". In this interview, Howe discusses tolerance, diversity and the parallels between his own life and his literature. Howe's four books in addition to "The Misfits" and "Totally Joe" and his list of recommended books with lesbian, gay, bisexual, transgender,…

  17. Stapp's quantum dualism: The James/Heisenberg model of consciousness

    International Nuclear Information System (INIS)

    Noyes, H.P.

    1994-01-01

    Henry Stapp attempts to resolve the Cartesian dilemma by introducing what the author would characterize as an ontological dualism between mind and matter. His model for mind comes from William James' description of conscious events and for matter from Werner Heisenberg's ontological model for quantum events (wave function collapse). His demonstration of the isomorphism between the two types of events is successful, but in the author's opinion fails to establish a monistic, scientific theory. The author traces Stapp's failure to his adamant rejection of arbitrariness, or 'randomness'. This makes it impossible for him (or for Bohr and Pauli before him) to understand the power of Darwin's explanation of biology, let along the triumphs of modern 'neo-Darwinism'. The author notes that the point at issue is a modern version of the unresolved opposition between Leucippus and Democritus on one side and Epicurus on the other. Stapp's views are contrasted with recent discussions of consciousness by two eminent biologists: Crick and Edelman. They locate the problem firmly in the context of natural selection on the surface of the earth. Their approaches provide a sound basis for further scientific work. The author briefly examines the connection between this scientific (rather than ontological) framework and the new fundamental theory based on bit-strings and the combinatorial hierarchy

  18. SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

    Directory of Open Access Journals (Sweden)

    Chi-Hsien Peng

    2010-06-01

    Full Text Available Retinal stem cells bear potency of proliferation, self-renewal, and differentiation into many retinal cells. Utilizing appropriate sensors one can effectively detect the self-renewal and aging process abilities. Silencing information regulator (SirT1, a member of the sirtuin family, is a NAD-dependent histone deacetylase and an essential mediator for longevity in normal cells by calorie restriction. We firstly investigate the SirT1 mRNA expression in retinal stem cells from rats and 19 human eyes of different ages. Results revealed that SirT1 expression was significantly decreased in in vivo aged eyes, associated with poor self-renewal abilities. Additionally, SirT1 mRNA levels were dose-dependently increased in resveratrol- treated retinal stem cells. The expression of SirT1 on oxidative stress-induced damage was significantly decreased, negatively correlated with the level of intracellular reactive oxygen species production. Treatment with resveratrol could effectively further reduce oxidative stress induced by H2O2 treatment in retinal stem cells. Importantly, the anti-oxidant effects of resveratrol in H2O2-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1. SirT1 expression provides a feasible sensor in assessing self-renewal and aging process in retinal stem cells. Resveratrol can prevent reactive oxygen species-induced damages via increased retinal SirT1 expression.

  19. "Cet obscur objet du Désir"

    Directory of Open Access Journals (Sweden)

    Reto Melchior

    1996-09-01

    Full Text Available Luis Bunuel’s last film is based on Pierre Louÿs’ La Femme et le Pantin. This now forgotten bestseller, published in 1898, is drawn from Goya s painting El Pelele, in which four women are playing with a male puppet. In Pierre Louÿs’ novel this scene is inverted so that one woman with two faces plays with four men. In Cet Obscur Objet du Désir this “femme fatale” is interpreted by two actresses. The concentric structure of the film puts focus on a scene of being excluded from knowing. The technique of continually interrupting the flash-back sequences frustrates the audience because of its exclusion from the “real” course of events and gives rise to doubts whether the male protagonist tells the truth about his love-affair or whether he satisfies the curiosity of the audience by telling them Pierre Louÿs’ novel as his own story. This ambiguous art of narration mirrors Bunuel’s claim that the main topic of Cet Obscur Objet du Désir is frustration.

  20. 'Who is wise and understanding among you' (James 3: 13? An analysis of wisdom, eschatology and apocalypticism in the epistle of James

    Directory of Open Access Journals (Sweden)

    Patrick J. Hartin

    1997-12-01

    Full Text Available Three questions form the basis of this analysis of the relationship of the Epistle of James to the traditions of wisdom, eschatology and apocalypticism. What kind of traditions are involved in James? What is the world view of James? What audience or community is presupposed by this writing? Foremost is the connection that James demonstrates to the wisdom tradition evident in the Old Testament and extratestamental literature. In particular two types of wisdom tradition are noted in James: practical wisdom advice as expressed in short sayings, wisdom instructions and admonitions and reflection on the nature of wisdom (1:5-8; 2:1-7; and 3:13-18 as coming from God. Finally, the question of how much apocalyptic symbolism is evident in the eschatological world view of the epistle is addressed.

  1. Sir Charles Scott Sherrington (1857–1952)

    Indian Academy of Sciences (India)

    Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from twentytwouniversities and ...

  2. Sir Charles Scott Sherrington (1857–1952)

    Indian Academy of Sciences (India)

    2016-08-26

    Aug 26, 2016 ... Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from ...

  3. Sir Ronald Ross and the Malarial Parasite

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 7. Sir Ronald Ross and the Malarial Parasite - Discovery of its Route - From Man to Mosquito and Back. Shobhona Sharma. General Article Volume 11 Issue 7 July 2006 pp 4-13 ...

  4. Sir Isaac Newton

    Directory of Open Access Journals (Sweden)

    E. A. Venter

    1964-03-01

    Full Text Available Die geweldige oplewing van die Christelike wetenskaps- gedagte in ons geeslose tyd, is ongetwyfeld ’n haas onverklaar- bare verskynsel. Dwarsdeur die eeue het Christene ook wetenskap beoefen saam met ongelowiges, maar dit was eers in ons leeftyd dat die principia van die Christelike religie ook vrugbaar gemaak is vir die wetenskapsbeoefening. In hierdie verband sal die name van Dooyeweerd, Vollenhoven, Stoker e.a. steeds met eer vermeld word. Natuurlik het belydende Christene ook voorheen wel deeglik saamgewerk aan die gebou van die wetenskap. Die intieme verband tussen religie, wysbegeerte en wetenskaps­ beoefening is toe egter nog nie suiwer ingesien nie. Uit hier­ die tydperk dateer die arbeid van sir Isaac Newton.

  5. Genetics Home Reference: Williams syndrome

    Science.gov (United States)

    ... do well on tasks that involve spoken language, music, and learning by repetition (rote memorization). Affected individuals ... Resources (5 links) Disease InfoSearch: Williams syndrome Genetic Science Learning Center, University of Utah MalaCards: williams-beuren ...

  6. WE-G-213-02: The AAPM Award Eponyms: William D. Coolidge, Edith H. Quimby, and Marvin M.D. Williams - Who Were They and What Did They Do?

    Energy Technology Data Exchange (ETDEWEB)

    Rothenberg, L. [Memorial Sloan-Kettering Cancer Center (United States)

    2015-06-15

    was hired by Giacchino Failla as a radiation physicist at Memorial Hospital for Cancer in New York City. Failla had studied with Madame Curie and obtained his doctoral degree in her laboratory. After many groundbreaking medical physics studies from 1919 until 1942, they both moved to Columbia University. Dr. Quimby developed a widely employed dosimetry system for single plane implants with radium and radon seeds, and a dosimetry methodology for internal radionuclides. She was author of more than 75 scientific publications, and of significant textbooks including the first comprehensive physics textbook for radiologists “Physical Foundations of Radiology”, which was co-authored with Otto Glasser, Lauriston Taylor and James Weatherwax in the first edition, with Russell Morgan added for the second edition and Paul Goodwin for the fourth edition. With Sergei Feitelberg, M.D. she published two editions of “Radioactive Isotopes in Medicine and Biology: Basic Physics and Instrumentation”. Quimby became a renowned examiner for the American Board of Radiology when the third ABR examination, given in 1936, added physics. She served as President of the American Radium Society, received the RSNA Gold Medal, and also numerous prestigious awards given to women in science. Edith Quimby was a Charter Member of AAPM. The AAPM Lifetime Achievement Award was renamed the Edith H. Quimby Lifetime Achievement Award in her honor in 2011. Marvin Martin Dixon Williams (1902–1981) Marvin Williams was born in Walla Walla, WA in 1902, and attended the same college as Edith Quimby, graduating from Whitman College in 1926. He was greatly influenced to go into medical physics by her accomplishments. During his early career, Williams worked with James Weatherwax in Philadelphia while he was working toward an M.S. from the University of Pennsylvania. In 1931 Williams was awarded a Ph.D. in Biophysics from the University of Minnesota, with the work actually performed at the Mayo Clinic

  7. WE-G-213-02: The AAPM Award Eponyms: William D. Coolidge, Edith H. Quimby, and Marvin M.D. Williams - Who Were They and What Did They Do?

    International Nuclear Information System (INIS)

    Rothenberg, L.

    2015-01-01

    was hired by Giacchino Failla as a radiation physicist at Memorial Hospital for Cancer in New York City. Failla had studied with Madame Curie and obtained his doctoral degree in her laboratory. After many groundbreaking medical physics studies from 1919 until 1942, they both moved to Columbia University. Dr. Quimby developed a widely employed dosimetry system for single plane implants with radium and radon seeds, and a dosimetry methodology for internal radionuclides. She was author of more than 75 scientific publications, and of significant textbooks including the first comprehensive physics textbook for radiologists “Physical Foundations of Radiology”, which was co-authored with Otto Glasser, Lauriston Taylor and James Weatherwax in the first edition, with Russell Morgan added for the second edition and Paul Goodwin for the fourth edition. With Sergei Feitelberg, M.D. she published two editions of “Radioactive Isotopes in Medicine and Biology: Basic Physics and Instrumentation”. Quimby became a renowned examiner for the American Board of Radiology when the third ABR examination, given in 1936, added physics. She served as President of the American Radium Society, received the RSNA Gold Medal, and also numerous prestigious awards given to women in science. Edith Quimby was a Charter Member of AAPM. The AAPM Lifetime Achievement Award was renamed the Edith H. Quimby Lifetime Achievement Award in her honor in 2011. Marvin Martin Dixon Williams (1902–1981) Marvin Williams was born in Walla Walla, WA in 1902, and attended the same college as Edith Quimby, graduating from Whitman College in 1926. He was greatly influenced to go into medical physics by her accomplishments. During his early career, Williams worked with James Weatherwax in Philadelphia while he was working toward an M.S. from the University of Pennsylvania. In 1931 Williams was awarded a Ph.D. in Biophysics from the University of Minnesota, with the work actually performed at the Mayo Clinic

  8. Sir Ronald Ross and the Malarial Parasite

    Indian Academy of Sciences (India)

    1997-08-20

    Aug 20, 1997 ... In 1857, a General in the Indian Army, Sir C C G Ross and his wife Matilda .... generally low-caste Indians who required a fee before drinking the water and ... nary demand being made upon their systems, as by fatigue, chill,.

  9. William Butler Yeats’s ‘The Symbolic System’ of William Blake

    Directory of Open Access Journals (Sweden)

    Arianna Antonielli

    2008-03-01

    Full Text Available The theosophical systems formulated by great poets, such as William Blake and William Butler Yeats, represent a personal idiosyncratic actualization of an ancient repertoire of magical symbols and occult visions. This study wants to focus the attention on the philosophical, mythical, and esoteric syncretism that W. B. Yeats drew from William Blake’s symbolical system. A fundamental step of Yeats’s deep investigation into the Blakean ‘vision’ was given by his monumental work, written together with Edwin John Ellis, on Blake’s poetic and pictorial production, completed in 1893 with a three-volume edition entitled The Works of William Blake, Poetic, Symbolic, and Critical. This work, published in London by Bernard Quaritch, deeply influenced Yeats’s symbolical and imaginary system, determining its subsequent development up to its codification in the volume of A Vision. With WWB, Yeats was able to systematize for the first time his own thought, giving unity to his Weltanschauung and his poetry. Following this hypothesis, I concentrated on Yeats’s and Ellis’s numerous analyses dedicated to Blake’s mythological and symbolical corpus and, in particular, I examined the last chapter of the first volume of the Quaritch edition. This chapter, entitled “The Symbolic System”, constitutes an unquestionable link between Yeats the reader and scholar of Blake, and Yeats the poet and follower of Blake.

  10. Converging Ideologies in William Fowler’s Hybrid Translation of Machiavelli’s Il Principe

    Directory of Open Access Journals (Sweden)

    Sergi Mainer

    2014-02-01

    Full Text Available This article explores the place of William Fowler’s translation of Machiavelli’s Prince in the Scottish Jacobean polysystem. Even if it was never finished, Fowler may have seen his rendering of Il Principe as a way of gaining King James’s favor at a time when Fowler had become a peripheral member at the sovereign’s court. Consequently, the translator’s hybrid deployment of three different sources, together with his own additions and suppressions, were aimed to conform to James VI’s political and cultural project. The ideological convergences between the king’s political thought and Fowler’s manipulated Prince supported and legitimized the existing power structures of the target culture. The unfinished/unedited state of the manuscript may suggest that a total reconciliation between James’s markedly idealized vision of kingship and government and Machiavelli’s treatise was impossible despite the translator’s intercultural and ethnocentric appropriation of the source text.

  11. A human neurodevelopmental model for Williams syndrome.

    Science.gov (United States)

    Chailangkarn, Thanathom; Trujillo, Cleber A; Freitas, Beatriz C; Hrvoj-Mihic, Branka; Herai, Roberto H; Yu, Diana X; Brown, Timothy T; Marchetto, Maria C; Bardy, Cedric; McHenry, Lauren; Stefanacci, Lisa; Järvinen, Anna; Searcy, Yvonne M; DeWitt, Michelle; Wong, Wenny; Lai, Philip; Ard, M Colin; Hanson, Kari L; Romero, Sarah; Jacobs, Bob; Dale, Anders M; Dai, Li; Korenberg, Julie R; Gage, Fred H; Bellugi, Ursula; Halgren, Eric; Semendeferi, Katerina; Muotri, Alysson R

    2016-08-18

    Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon hypersociability and a mosaic of retained and compromised linguistic and cognitive abilities. Nearly all clinically diagnosed individuals with Williams syndrome lack precisely the same set of genes, with breakpoints in chromosome band 7q11.23 (refs 1-5). The contribution of specific genes to the neuroanatomical and functional alterations, leading to behavioural pathologies in humans, remains largely unexplored. Here we investigate neural progenitor cells and cortical neurons derived from Williams syndrome and typically developing induced pluripotent stem cells. Neural progenitor cells in Williams syndrome have an increased doubling time and apoptosis compared with typically developing neural progenitor cells. Using an individual with atypical Williams syndrome, we narrowed this cellular phenotype to a single gene candidate, frizzled 9 (FZD9). At the neuronal stage, layer V/VI cortical neurons derived from Williams syndrome were characterized by longer total dendrites, increased numbers of spines and synapses, aberrant calcium oscillation and altered network connectivity. Morphometric alterations observed in neurons from Williams syndrome were validated after Golgi staining of post-mortem layer V/VI cortical neurons. This model of human induced pluripotent stem cells fills the current knowledge gap in the cellular biology of Williams syndrome and could lead to further insights into the molecular mechanism underlying the disorder and the human social brain.

  12. Environmental Assessment on the leasing of the Strategic Petroleum Reserve, St. James Terminal, St. James Parish, Louisiana

    International Nuclear Information System (INIS)

    1995-01-01

    The US Department of Energy (DOE) proposes to lease the Strategic Petroleum Reserve's (SPR) St. James Terminal to private industry. The St. James Terminal consists of six storage tanks, a pumping station, two maine docks and ancillary facilities. DOE believes that the St. James Terminal presents an opportunity to establish a government- industry arrangement that could more effectively use this asset to serve the nations's oil distribution needs, reduce the operational cost of the SPR, and provide a source of revenue for the Government. DOE solicited interest in leasing its distribution facilities in a notice published March 16, 1994. In response, industry has expressed interest in leasing the St. James Terminal, as well as several DOE pipelines, to enhance the operation of its own facilities or to avoid having to construct new ones. Under such a lease, industry use would be subordinate to DOE use in the event of a national energy emergency. This Environmental Assessment describes the proposed leasing operation, its alternatives, and potential environmental impacts. Based on this analyses, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA) OF 1969 and has issued the Finding of No Significant Impact (FONSI)

  13. Permanence for a Delayed Nonautonomous SIR Epidemic Model with Density-Dependent Birth Rate

    Directory of Open Access Journals (Sweden)

    Li Yingke

    2011-01-01

    Full Text Available Based on some well-known SIR models, a revised nonautonomous SIR epidemic model with distributed delay and density-dependent birth rate was considered. Applying some classical analysis techniques for ordinary differential equations and the method proposed by Wang (2002, the threshold value for the permanence and extinction of the model was obtained.

  14. SIR-2 Data Normalization and Integration with M3 Data

    Science.gov (United States)

    Grumpe, A.; Felder, M. P.; Wöhler, C.; Mall, U.

    2013-09-01

    The point spectrometer SIR-2 on Chandrayaan-1 provided radiance spectra integrated over circular footprints of 200 m diameter in the wavelength range 934-2410.8 nm in 256 channels [1]. To analyze SIR-2 reflectance spectra in their spatial context, a coregistration to Chandrayaan-1 M³ hyperspectral images [2] as well as a correction for topography and thermal emission are inevitable. The thermal and topographic correction procedure is based on the surface temperature and a digital elevation model (DEM) inferred from M³ data. The corrected reflectance spectra are then normalized to a standard illumination and viewing geometry.

  15. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression

    International Nuclear Information System (INIS)

    Chang, C.-J.; Hsu, C.-C.; Yung, M.-C.; Chen, K.-Y.; Tzao Ching; Wu, W.-F.; Chou, H.-Y.; Lee, Y.-Y.; Lu, K.-H.; Chiou, S.-H.; Ma, H.-I

    2009-01-01

    CD133-expressing glioma cells play a critical role in tumor recovery after treatment and are resistant to radiotherapy. Herein, we demonstrated that glioblastoma-derived CD133-positive cells (GBM-CD133 + ) are capable of self-renewal and express high levels of embryonic stem cell genes and SirT1 compared to GBM-CD133 - cells. To evaluate the role of SirT1 in GBM-CD133 + , we used a lentiviral vector expressing shRNA to knock-down SirT1 expression (sh-SirT1) in GBM-CD133 + . Silencing of SirT1 significantly enhanced the sensitivity of GBM-CD133 + to radiation and increased the level of radiation-mediated apoptosis. Importantly, knock-down of SirT1 increased the effectiveness of radiotherapy in the inhibition of tumor growth in nude mice transplanted with GBM-CD133 + . Kaplan-Meier survival analysis indicated that the mean survival rate of GBM-CD133 + mice treated with radiotherapy was significantly improved by Sh-SirT1 as well. In sum, these results suggest that SirT1 is a potential target for increasing the sensitivity of GBM and glioblastoma-associated cancer stem cells to radiotherapy.

  16. Serum inflammatory markers in the elderly: are they useful in differentiating sepsis from SIRS?

    Directory of Open Access Journals (Sweden)

    Mahshid Talebi-Taher

    2014-06-01

    Full Text Available Differentiating sepsis from other noninfectious causes of systemic inflammation is often difficult in the elderly. The aim of this study was to evaluate the ability of C-reactive protein (CRP, Erythrocyte Sedimentation Rate (ESR, procalcitonin (PCT, and Interleukin-6 (IL-6 to identify elderly patients with sepsis. In this single center prospective observational study, we included all consecutive elderly patients admitted with suspected sepsis and systemic inflammatory response syndrome (SIRS in an emergency department. Blood samples for measuring CRP, PCT, IL-6, ESR and white blood cells (WBC count were taken at first day of admission. Sensitivity, specificity, positive and negative predictive values were calculated for each inflammatory markers being studied. A total of 150 elderly patients aged 65 and older, 50 with sepsis and 50 with SIRS, and fifty individuals in a normal health status were included. CRP exhibited the greatest sensitivity (98% and negative predictive value (98.6% and performed best in differentiating patients with sepsis from those with SIRS. In a receiver operating characteristic curve analysis, IL-6 performed best in distinguishing between SIRS and the control group (AUC 0.75, 95% CI. On the other hand, both CRP and ESR appeared to be a more accurate diagnostic parameter for differentiating sepsis from SIRS among elderly patients.

  17. Operations Events Census Report: Volume III, 1975-1980. Sanitized Version.

    Science.gov (United States)

    1985-04-01

    2 0971 WILKINSON, WILLIAM 2 0746 122 Personnel Dose Information_ 1977 ID ORG. NAME CODE CODE WILLIAMS, ALONZO 2 0961 WILLIAMS, DAVE S. 2 0971...0903 GONZALEZ, DAVE 2 0874 GOOD, JACKIE C. 2 0837 GOOD, JAMES H. 2 0845 GORDON, DONALD C. 2 0680 GORDON, JAMES A. 2 0879 GORE, ARWIND K. 2 0679 GORMAN...0687 ZERGA, DONALD L. 2 0918 ZERGA, SUSAN J. 2 0918 ZIELINSKI , KENNETH 2 0679 ZIKA, ANDREW P., III 2 0837 ZIMMERMAN, DOUGLAS E. 2 0918 ZYGAN, ROBERT

  18. dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

    Directory of Open Access Journals (Sweden)

    Kushal Kr. Banerjee

    2012-12-01

    Full Text Available Sir2, an evolutionarily conserved NAD+-dependent deacetylase, has been implicated as a key factor in mediating organismal life span. However, recent contradictory findings have brought into question the role of Sir2 and its orthologs in regulating organismal longevity. In this study, we report that Drosophila Sir2 (dSir2 in the adult fat body regulates longevity in a diet-dependent manner. We used inducible Gal4 drivers to knock down and overexpress dSir2 in a tissue-specific manner. A diet-dependent life span phenotype of dSir2 perturbations (both knockdown and overexpression in the fat body, but not muscles, negates the effects of background genetic mutations. In addition to providing clarity to the field, our study contrasts the ability of dSir2 in two metabolic tissues to affect longevity. We also show that dSir2 knockdown abrogates fat-body dFOXO-dependent life span extension. This report highlights the importance of the interplay between genetic factors and dietary inputs in determining organismal life spans.

  19. Social and environmental impacts of the James Bay hydroelectric project

    International Nuclear Information System (INIS)

    Hornig, J.F.

    1999-01-01

    The book, which is an analysis and not an advocacy, examines the anatomy of the controversy that has swirled around the James Bay project - the La Grande and Great Whale projects combined - from the 1970s to the 1990s, and seeks, in the process, to determine whether there are lessons that can be learned from such an analysis that are applicable to other cases as well as to James Bay itself. The contributors are interested, at one and the same time, in finding ways to integrate the knowledge of natural scientists and social scientists to deepen the understanding of human/environment relations and to link science and policy to encourage a productive dialogue between practitioners and scholars in this increasingly important area of inquiry. The contributor's papers include the following: introduction to the issues; hydroelectric power development at James Bay: establishing a frame of reference; James Bay: environmental considerations for building large hydroelectric dams and reservoirs in Quebec; elevated mercury in fish as a result of the James Bay hydroelectric power development: perception and reality; the Cree people of James Bay: assessing the social impacts of hydroelectric dams and reservoirs; culture, social change, and Cree opposition to the James Bay hydroelectric development; and the impact of James Bay hydroelectric development on the art and craft of the James Bay Cree. The authors of the volume have attempted to stand back and examine just a few of these issues from the perspective of a variety of disciplines, and their purpose is to inform and stimulate thoughtful consideration by providing an overall perspective that might might serve to broaden the context in which specific issues can be debated. refs., 3 tabs., 5 figs

  20. Comparison of QSOFA score and SIRS criteria as screening mechanisms for emergency department sepsis.

    Science.gov (United States)

    Haydar, Samir; Spanier, Matthew; Weems, Patricia; Wood, Samantha; Strout, Tania

    2017-11-01

    The Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) score has been shown to accurately predict mortality in septic patients and is part of recently proposed diagnostic criteria for sepsis. We sought to ascertain the sensitive of the score in diagnosing sepsis, as well as the diagnostic timeliness of the score when compared to traditional systemic inflammatory response syndrome (SIRS) criteria in a population of emergency department (ED) patients treated in the ED, admitted, and subsequently discharged with a diagnosis of sepsis. Electronic health records of 200 patients who were treated for suspected sepsis in our ED and ultimately discharged from our hospital with a diagnosis of sepsis were randomly selected for review from a population of adult ED patients (N=1880). Data extracted included the presence of SIRS criteria and the qSOFA score as well as time required to meet said criteria. In this cohort, 94.5% met SIRS criteria while in the ED whereas only 58.3% met qSOFA. The mean time from arrival to SIRS documentation was 47.1min (95% CI: 36.5-57.8) compared to 84.0min (95% CI: 62.2-105.8) for qSOFA. The median ED "door" to positive SIRS criteria was 12min and 29min for qSOFA. Although qSOFA may be valuable in predicting sepsis-related mortality, it performed poorly as a screening tool for identifying sepsis in the ED. As the time to meet qSOFA criteria was significantly longer than for SIRS, relying on qSOFA alone may delay initiation of evidence-based interventions known to improve sepsis-related outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Environmental Assessment on the leasing of the Strategic Petroleum Reserve, St. James Terminal, St. James Parish, Louisiana

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-01-01

    The US Department of Energy (DOE) proposes to lease the Strategic Petroleum Reserve`s (SPR) St. James Terminal to private industry. The St. James Terminal consists of six storage tanks, a pumping station, two maine docks and ancillary facilities. DOE believes that the St. James Terminal presents an opportunity to establish a government- industry arrangement that could more effectively use this asset to serve the nations`s oil distribution needs, reduce the operational cost of the SPR, and provide a source of revenue for the Government. DOE solicited interest in leasing its distribution facilities in a notice published March 16, 1994. In response, industry has expressed interest in leasing the St. James Terminal, as well as several DOE pipelines, to enhance the operation of its own facilities or to avoid having to construct new ones. Under such a lease, industry use would be subordinate to DOE use in the event of a national energy emergency. This Environmental Assessment describes the proposed leasing operation, its alternatives, and potential environmental impacts. Based on this analyses, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA) OF 1969 and has issued the Finding of No Significant Impact (FONSI).

  2. Tribute to the legend Mr. Veterinary Public Health, Professor James ...

    African Journals Online (AJOL)

    The author was also destined during his Sabbatical Leave to have an interactive interview session with Prof James Steele after attending the 20th Annual James Steele lecture/ 99th birthday Dinner of Professor James Steele 4th and 6th April 2012 at the Texas School of Public Health, Houston, Texas, USA. The interview ...

  3. Delineation of major geologic structures in Turkey using SIR-B data

    Science.gov (United States)

    Toksoz, M. N.; Pettengill, G. H.; Ford, P.; Gulen, L.

    1984-01-01

    Shuttle Imaging Radar-B (SIR-B) images of well mapped segments of major faults, such as the North Anatolian Fault (NAF) and East Anatolian Fault (EAF) will be studied to identify the prominent signatures that characterize the fault zones for those specific regions. The information will be used to delineate the unmapped fault zones in areas with similar geological and geomorphological properties. The data obtained from SIR-B images will be compared and correlated with the LANDSAT thematic mapper and seismicity alignments based on well constrained earthquake epicenters.

  4. Handedness and corpus callosal morphology in Williams syndrome.

    Science.gov (United States)

    Martens, Marilee A; Wilson, Sarah J; Chen, Jian; Wood, Amanda G; Reutens, David C

    2013-02-01

    Williams syndrome is a neurodevelopmental genetic disorder caused by a hemizygous deletion on chromosome 7q11.23, resulting in atypical brain structure and function, including abnormal morphology of the corpus callosum. An influence of handedness on the size of the corpus callosum has been observed in studies of typical individuals, but handedness has not been taken into account in studies of callosal morphology in Williams syndrome. We hypothesized that callosal area is smaller and the size of the splenium and isthmus is reduced in individuals with Williams syndrome compared to healthy controls, and examined age, sex, and handedness effects on corpus callosal area. Structural magnetic resonance imaging scans were obtained on 25 individuals with Williams syndrome (18 right-handed, 7 left-handed) and 25 matched controls. We found that callosal thickness was significantly reduced in the splenium of Williams syndrome individuals compared to controls. We also found novel evidence that the callosal area was smaller in left-handed participants with Williams syndrome than their right-handed counterparts, with opposite findings observed in the control group. This novel finding may be associated with LIM-kinase hemizygosity, a characteristic of Williams syndrome. The findings may have significant clinical implications in future explorations of the Williams syndrome cognitive phenotype.

  5. WE-G-213-00: History Symposium: Radiological Physics Pioneers: Roentgen and the AAPM Award Eponyms - William Coolidge, Edith Quimby, and Marvin Williams - Who Were They and What Did They Do?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    was hired by Giacchino Failla as a radiation physicist at Memorial Hospital for Cancer in New York City. Failla had studied with Madame Curie and obtained his doctoral degree in her laboratory. After many groundbreaking medical physics studies from 1919 until 1942, they both moved to Columbia University. Dr. Quimby developed a widely employed dosimetry system for single plane implants with radium and radon seeds, and a dosimetry methodology for internal radionuclides. She was author of more than 75 scientific publications, and of significant textbooks including the first comprehensive physics textbook for radiologists “Physical Foundations of Radiology”, which was co-authored with Otto Glasser, Lauriston Taylor and James Weatherwax in the first edition, with Russell Morgan added for the second edition and Paul Goodwin for the fourth edition. With Sergei Feitelberg, M.D. she published two editions of “Radioactive Isotopes in Medicine and Biology: Basic Physics and Instrumentation”. Quimby became a renowned examiner for the American Board of Radiology when the third ABR examination, given in 1936, added physics. She served as President of the American Radium Society, received the RSNA Gold Medal, and also numerous prestigious awards given to women in science. Edith Quimby was a Charter Member of AAPM. The AAPM Lifetime Achievement Award was renamed the Edith H. Quimby Lifetime Achievement Award in her honor in 2011. Marvin Martin Dixon Williams (1902–1981) Marvin Williams was born in Walla Walla, WA in 1902, and attended the same college as Edith Quimby, graduating from Whitman College in 1926. He was greatly influenced to go into medical physics by her accomplishments. During his early career, Williams worked with James Weatherwax in Philadelphia while he was working toward an M.S. from the University of Pennsylvania. In 1931 Williams was awarded a Ph.D. in Biophysics from the University of Minnesota, with the work actually performed at the Mayo Clinic

  6. WE-G-213-00: History Symposium: Radiological Physics Pioneers: Roentgen and the AAPM Award Eponyms - William Coolidge, Edith Quimby, and Marvin Williams - Who Were They and What Did They Do?

    International Nuclear Information System (INIS)

    2015-01-01

    was hired by Giacchino Failla as a radiation physicist at Memorial Hospital for Cancer in New York City. Failla had studied with Madame Curie and obtained his doctoral degree in her laboratory. After many groundbreaking medical physics studies from 1919 until 1942, they both moved to Columbia University. Dr. Quimby developed a widely employed dosimetry system for single plane implants with radium and radon seeds, and a dosimetry methodology for internal radionuclides. She was author of more than 75 scientific publications, and of significant textbooks including the first comprehensive physics textbook for radiologists “Physical Foundations of Radiology”, which was co-authored with Otto Glasser, Lauriston Taylor and James Weatherwax in the first edition, with Russell Morgan added for the second edition and Paul Goodwin for the fourth edition. With Sergei Feitelberg, M.D. she published two editions of “Radioactive Isotopes in Medicine and Biology: Basic Physics and Instrumentation”. Quimby became a renowned examiner for the American Board of Radiology when the third ABR examination, given in 1936, added physics. She served as President of the American Radium Society, received the RSNA Gold Medal, and also numerous prestigious awards given to women in science. Edith Quimby was a Charter Member of AAPM. The AAPM Lifetime Achievement Award was renamed the Edith H. Quimby Lifetime Achievement Award in her honor in 2011. Marvin Martin Dixon Williams (1902–1981) Marvin Williams was born in Walla Walla, WA in 1902, and attended the same college as Edith Quimby, graduating from Whitman College in 1926. He was greatly influenced to go into medical physics by her accomplishments. During his early career, Williams worked with James Weatherwax in Philadelphia while he was working toward an M.S. from the University of Pennsylvania. In 1931 Williams was awarded a Ph.D. in Biophysics from the University of Minnesota, with the work actually performed at the Mayo Clinic

  7. 33 CFR 167.1700 - In Prince William Sound: General.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false In Prince William Sound: General... Schemes and Precautionary Areas Pacific West Coast § 167.1700 In Prince William Sound: General. The Prince William Sound Traffic Separation Scheme consists of four parts: Prince William Sound Traffic Separation...

  8. SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells

    International Nuclear Information System (INIS)

    Xie Yuexia; Zhang Jianghong; Shao Chunlin; Xu Yanwu

    2012-01-01

    Intratumoral hypoxia is an important contributory factor to tumor cell resistance to radiotherapy. SirT1, a nicotinamide adenine dinucleotide (NAD + )-dependent histone/protein deacetylase, has been linked to the decrease of radiation-induced DNA damage and seems to be critical for cancer therapy. The purpose of this study was to investigate the role of SirT1 in hypoxia-induced radiation response on hepatoma cells. It was found that the administration with resveratrol, a putative SirT1 activator, enhanced the resistance of HepG2 cells against radiation-induced DNA damage of MN formation under hypoxia condition; while nicotinamide, a well-known SirT1 inhibitor, sensitized this radiation damage. Nevertheless, pretreatment of cells with 10058-F4, a specific inhibitor of c-Myc, almost eliminated the nicotinamide-induced radiosensitive effect. Further studies revealed that resveratrol inhibited c-Myc protein accumulation via up-regulation of SirT1 expression and deacetylase activity, and this loss of c-Myc protein was abolished by inhibiting its degradation in the presence of MG132, a potent inhibitor of proteasome. In contrast, nicotinamide attenuated c-Myc protein degradation induced by radiation under hypoxia through inhibition of SirT1 deacetylase activity. Our findings suggest that SirT1 could serve as a novel potent target of radiation-induced DNA damage and thus as a potential strategy to advance the efficiency of radiation therapy in hepatoma entities. (author)

  9. The susceptible-infected-recovered (SIR) model for viral marketing

    Science.gov (United States)

    Ismail, Siti Suhaila; Akil, Ku Azlina Ku; Chulan, Majdah; Sharif, Noorzila

    2017-11-01

    Viral marketing is a marketing strategy utilizes social media to spread information about a product or services provided. It is the most powerful way to share information in a short amount of time. The objective of this study is to investigate the dynamic of viral marketing within a time duration in the point of view of mathematics. This study used the epidemiological model known as Susceptible-Infected-Recovered (SIR). The model consists of a system of three differential equations with three state variables namely susceptible (S), infected (I) and recovered (R). It considers a case of SIR model with demography. Numerical experiments have been performed. The results show that viral marketing reaches its peak within two days. The online messages shared will become higher if the initial number of the infected individual has been increased.

  10. Porters, watchmen, and the crime of William Sayers: the non-scientific staff of the Royal Observatory, Greenwich, in Victorian times

    Science.gov (United States)

    Chapman, Allan

    2003-06-01

    A careful study of the detailed archives of the Victorian Royal Observatory makes it possible to build up a picture of the employment and working conditions not only of the astronomical staff who worked at Greenwich, but also of the labourers, watchmen, and gate porters. Indeed, the archives open up a window on to how the Observatory was run on a daily basis: how its non-scientific staff were recruited and paid, and what were their terms of employment. They also say a great deal about how Sir George Biddell Airy directed and controlled every aspect of the Observatory's life. Yet while Airy was a strict employer, he emerges as a man who was undoubtedly fair-minded and sometimes even generous to his non-scientific work-force. A study of the Observatory staff files also reveals the relationship between the Observatory labouring staff and the Airy family's domestic servants. And of especial interest is the robbery committed by William Sayers, the Airy family footman in 1868, bringing to light as it does Sir George and Lady Richarda Airy's views on crime and its social causes and consequences, the prison rehabilitation service in 1868, and their opinions on the reform of offenders. Though this paper is not about astronomy as such, it illuminates a fascinating interface where the world of astronomical science met and worked alongside the world of ordinary Victorian people within the walls of one of the nineteenth century's most illustrious astronomical institutions.

  11. Sir Karl Popper and his philosophy of physics

    Science.gov (United States)

    Jammer, Max

    1991-12-01

    The eminent mathematical physicist Sir Hermann Bondi once said: “There is no more to science than its method, and there is no more to its method than Popper has said.” Indeed, many regard Sir Karl Raimund Popper the greatest philosopher of science in our generation. Much of what Popper “has said” refers to physics, but physicists, generally speaking, have little knowledge of what he has said. True, Popper's philosophy of science and, in particular, his realistic interpretation of quantum mechanics deviates considerably from the generally accepted doctrine. But as Popper, rightly I think, points out, it is precisely the proliferation of divergent theories which promotes the growth of scientific knowledge; it would be a danger for physics if physicists were dogmatically tied to a single theory or would not test their theory against alternatives. It is for this purpose that, on the occasion of the nonagenarian celebration of Popper's birthday, the present essay has been written.

  12. Verification of the linearity of the new SIR using sources of 64Cu and 99mTc

    International Nuclear Information System (INIS)

    Michotte, Carine

    2012-02-01

    The linearity of the new SIR electronics has been verified by looking for deviations from the exponential decay for several 64 Cu and 99m Tc sources. Data analyses are compared with the half-life used as a fixed or free parameter. It is concluded that no significant non-linearity is observed in the new SIR. For comparison, the same method has been applied to analyse existing data from the original SIR. (author)

  13. Sir Robert Sidney’s Poems Revisited: the alternative sequence

    OpenAIRE

    Relvas, Maria de Jesus C.

    1997-01-01

    The essay approaches the lyric sequence written by Sir Robert Sidney (1563-1626) in the Elizabethan age, by mainly exploring its unique formal structure, which encloses an alternative sequence formed by a re-numbering of several poems.

  14. Edinburgh, the Scottish pioneers of anatomy and their lasting influence in South Africa.

    Science.gov (United States)

    Correia, J C; Wessels, Q; Vorster, W

    2013-11-01

    The history of the origin of anatomy education in South Africa is the history of an arduous journey through time. The lasting influence of Edinburgh came in the form of Robert Black Thomson. He was a student and assistant of Sir William Turner who gave rise to the first chair of anatomy and the establishment of a department at the South African College, known today as University of Cape Town. Thomson was later succeeded by Matthew Drennan, a keen anthropologist, who was revered by his students. This Scottish link prevailed over time with the appointment of Edward Philip Stibbe as the chair of anatomy at the South African School of Mines and Technology, which later became the University of the Witwatersrand. Stibbe's successor, Raymond Arthur Dart, a graduate of the University of Sydney, was trained in an anatomy department sculpted on that of Edinburgh by Professor James Thomas Wilson. Wilson's influence at the University of Sydney can be traced back to Edinburgh and William Turner through Thomas Anderson Stuart. Both Dart and Robert Broom, another Scot, were considered as Africa's wild men by the late Professor Tobias. Here, the authors explore the Scottish link and origins of anatomy pedagogy in South Africa.

  15. SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation

    International Nuclear Information System (INIS)

    Xie, Yuexia; Tu, Wenzhi; Zhang, Jianghong; He, Mingyuan; Ye, Shuang; Dong, Chen; Shao, Chunlin

    2015-01-01

    Highlights: • γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells. • SirT1 played a protective role in regulating this bystander effect. • SirT1 contributed to the protective effects via elimination the accumulation of ROS. • The activity of c-Myc is critical for maintaining the protective role of SirT1. - Abstract: Radiation-induced bystander effect (RIBE) has important implications for secondary cancer risk assessment during cancer radiotherapy, but the bystander signaling processes, especially under hypoxic condition, are still largely unclear. The present study found that micronuclei (MN) formation could be induced in the non-irradiated HL-7702 hepatocyte cells after being treated with the conditioned medium from irradiated hepatoma HepG2 and SK-Hep-1 cells under either normoxia or hypoxia. This bystander response was dramatically diminished or enhanced when the SirT1 gene of irradiated hepatoma cells was overexpressed or knocked down, respectively, especially under hypoxia. Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation. But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference. Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion. These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved

  16. SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation

    Energy Technology Data Exchange (ETDEWEB)

    Xie, Yuexia [Institute of Radiation Medicine, Fudan University, Shanghai (China); Central Laboratory, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai (China); Tu, Wenzhi; Zhang, Jianghong; He, Mingyuan; Ye, Shuang; Dong, Chen [Institute of Radiation Medicine, Fudan University, Shanghai (China); Shao, Chunlin, E-mail: clshao@shmu.edu.cn [Institute of Radiation Medicine, Fudan University, Shanghai (China)

    2015-02-15

    Highlights: • γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells. • SirT1 played a protective role in regulating this bystander effect. • SirT1 contributed to the protective effects via elimination the accumulation of ROS. • The activity of c-Myc is critical for maintaining the protective role of SirT1. - Abstract: Radiation-induced bystander effect (RIBE) has important implications for secondary cancer risk assessment during cancer radiotherapy, but the bystander signaling processes, especially under hypoxic condition, are still largely unclear. The present study found that micronuclei (MN) formation could be induced in the non-irradiated HL-7702 hepatocyte cells after being treated with the conditioned medium from irradiated hepatoma HepG2 and SK-Hep-1 cells under either normoxia or hypoxia. This bystander response was dramatically diminished or enhanced when the SirT1 gene of irradiated hepatoma cells was overexpressed or knocked down, respectively, especially under hypoxia. Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation. But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference. Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion. These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved.

  17. William Rowan Hamilton: Mathematical genius

    International Nuclear Information System (INIS)

    Wilkins, D.R.

    2006-01-01

    This year Ireland celebrates the bicentenary of the mathematician William Rowan Hamilton, best remembered for quaternions and for his pioneering work on optics and dynamics. Two centuries after his birth, the extent to which terms such as Hamiltonian and Hamiltonian system have entered the everyday language of mathematicians and physicists testifies to the continuing impact of the scientific work of William Rowan Hamilton. (U.K.)

  18. Stapp`s quantum dualism: The James/Heisenberg model of consciousness

    Energy Technology Data Exchange (ETDEWEB)

    Noyes, H.P.

    1994-02-18

    Henry Stapp attempts to resolve the Cartesian dilemma by introducing what the author would characterize as an ontological dualism between mind and matter. His model for mind comes from William James` description of conscious events and for matter from Werner Heisenberg`s ontological model for quantum events (wave function collapse). His demonstration of the isomorphism between the two types of events is successful, but in the author`s opinion fails to establish a monistic, scientific theory. The author traces Stapp`s failure to his adamant rejection of arbitrariness, or `randomness`. This makes it impossible for him (or for Bohr and Pauli before him) to understand the power of Darwin`s explanation of biology, let along the triumphs of modern `neo-Darwinism`. The author notes that the point at issue is a modern version of the unresolved opposition between Leucippus and Democritus on one side and Epicurus on the other. Stapp`s views are contrasted with recent discussions of consciousness by two eminent biologists: Crick and Edelman. They locate the problem firmly in the context of natural selection on the surface of the earth. Their approaches provide a sound basis for further scientific work. The author briefly examines the connection between this scientific (rather than ontological) framework and the new fundamental theory based on bit-strings and the combinatorial hierarchy.

  19. SIR JOHN CRAWFORD MEMORIAL ADDRESS: Agriculture: The challenges of the 21st century

    OpenAIRE

    Beddington, Sir John

    2012-01-01

    The Sir John Crawford Memorial Address has been presented since 1985, in honour of the distinguished Australian civil servant, educator and agriculturalist in whose name the Crawford Fund was established. Sir John Crawford was a remarkable Australian who contributed at the highest levels, and was a passionate supporter of international agricultural research for development. This talk draws attention to four current and interrelated trends that suggest the world will be rather different by 202...

  20. Stability analysis of the Euler discretization for SIR epidemic model

    International Nuclear Information System (INIS)

    Suryanto, Agus

    2014-01-01

    In this paper we consider a discrete SIR epidemic model obtained by the Euler method. For that discrete model, existence of disease free equilibrium and endemic equilibrium is established. Sufficient conditions on the local asymptotical stability of both disease free equilibrium and endemic equilibrium are also derived. It is found that the local asymptotical stability of the existing equilibrium is achieved only for a small time step size h. If h is further increased and passes the critical value, then both equilibriums will lose their stability. Our numerical simulations show that a complex dynamical behavior such as bifurcation or chaos phenomenon will appear for relatively large h. Both analytical and numerical results show that the discrete SIR model has a richer dynamical behavior than its continuous counterpart

  1. William Rowan Hamilton: Mathematical genius

    Energy Technology Data Exchange (ETDEWEB)

    Wilkins, D.R. [School of Mathematics, Trinity College, Dublin (Ireland)]. E-mail: dwilkins@maths.tcd.ie

    2005-08-01

    This year Ireland celebrates the bicentenary of the mathematician William Rowan Hamilton, best remembered for 'quaternions' and for his pioneering work on optics and dynamics. Two centuries after his birth, the extent to which terms such as 'Hamiltonian' and 'Hamiltonian system' have entered the everyday language of mathematicians and physicists testifies to the continuing impact of the scientific work of William Rowan Hamilton. (U.K.)

  2. James Cronin, CP Violation, and the Pierre Auger Observatory

    Science.gov (United States)

    dropdown arrow Site Map A-Z Index Menu Synopsis James Cronin, CP Violation and the Pierre Auger Observatory matter over antimatter."1 "The experiment uncovered the CP [charge-parity] violation, or a with Additional Information Additional information about James Cronin and the charge-parity (CP

  3. 33 CFR 110.233 - Prince William Sound, Alaska.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Prince William Sound, Alaska. 110... ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.233 Prince William Sound, Alaska. (a) The anchorage grounds. In Prince William Sound, Alaska, beginning at a point at latitude 60°40′00″ N., longitude 146°40...

  4. L’économie politique du désir dans le rituel et le militantisme au SriLanka

    Directory of Open Access Journals (Sweden)

    Wim Van Daele

    2013-03-01

    Full Text Available Le désir est au cœur des interactions complexes entre le développement et la religion. Cet article examine ses différentes expressions, comme étant une des préoccupations fondamentales de nombreuses religions, qui motivent à la fois le développement et les alternatives au développement. Au SriLanka, face au changement social, la forme néolibérale et mondialisée du développement est comprise et réinterprétée à travers des idiomes et des formations locales du désir. L’économie néolibérale cultive le désir et mène à un accroissement présumé de la présence des preta (fantômes affamés et avides qui se manifestent parfois au moment de la mort d’une personne. Les fantômes affamés, en tant que formations fétichisées du désir, trouvent un écho chez les consommateurs et les entrepreneurs, qui montrent unappétit insatiable vis-à-vis d’une richesse matérielle en constante croissance. Ainsi, l’apaisement ritualisé des fantômes affamés et le militantisme social de groupes tels que le Movement for National Land and Agricultural Reform (MONLAR sont clairement liés par leur préoccupation mutuelle face à l’insécurité existentielle des êtres humains et non humains, causée par un désir excessif et déséquilibré. L’action rituelle et le militantisme social divergent toutefois dans la formulation explicite de leurs préoccupations spécifiques concernant le désir. Le rituel matérialise et condense l’angoisse liée au désir, alors que le militantisme social décrit la fétichisation du désir en termes économiques, politiques et scientifiques plus abstraits.

  5. Williams Syndrome with a “Twist”

    Directory of Open Access Journals (Sweden)

    Despoina Maritsi

    2010-01-01

    Full Text Available Williams syndrome is a rare genetic condition with multisystemic involvement, caused by a microscopic deletion in the chromosome band 7q11.23. We describe the first case of a toddler with Williams syndrome who developed Benign Paroxysmal Torticollis (BPT, a benign dystonic disorder of unknown aetiology.

  6. Bicomplex holomorphic functions the algebra, geometry and analysis of bicomplex numbers

    CERN Document Server

    Luna-Elizarrarás, M Elena; Struppa, Daniele C; Vajiac, Adrian

    2015-01-01

    The purpose of this book is to develop the foundations of the theory of holomorphicity on the ring of bicomplex numbers. Accordingly, the main focus is on expressing the similarities with, and differences from, the classical theory of one complex variable. The result is an elementary yet comprehensive introduction to the algebra, geometry and analysis of bicomplex numbers. Around the middle of the nineteenth century, several mathematicians (the best known being Sir William Hamilton and Arthur Cayley) became interested in studying number systems that extended the field of complex numbers. Hamilton famously introduced the quaternions, a skew field in real-dimension four, while almost simultaneously James Cockle introduced a commutative four-dimensional real algebra, which was rediscovered in 1892 by Corrado Segre, who referred to his elements as bicomplex numbers. The advantages of commutativity were accompanied by the introduction of zero divisors, something that for a while dampened interest in this subject. ...

  7. 76 FR 1130 - Prince William Sound Resource Advisory Committee

    Science.gov (United States)

    2011-01-07

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource Advisory... conducted: The Prince William Sound Resource Advisory Committee (RAC) will be discussing and voting on...

  8. 77 FR 45331 - Prince William Sound Resource Advisory Committee

    Science.gov (United States)

    2012-07-31

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource Advisory... Prince William Sound Resource Advisory Committee (RAC) will be discussing and voting on proposals that...

  9. Ending Caleb Williams: on storytelling influencing William Godwin’s politics

    Directory of Open Access Journals (Sweden)

    Peterson Roberto da Silva

    2017-12-01

    Full Text Available William Godwin escreveu o romance gótico Things as They Are; or, the Adventures of Caleb Williams (“As Coisas como Elas São; ou, as Aventuras de Caleb Williams”, em tradução livre em 1794 para disseminar suas ideias filosóficas e políticas. Inicio o artigo revisando a literatura para demonstrar como sua teoria influenciou tanto sua decisão de escrever ficções quanto o tipo de ficção que ele escreveu, mostrando como o autor usou e inovou convenções do gênero gótico para transmitir suas ideias para um público mais amplo. Então comparo duas perspectivas divergentes na literatura quanto à maneira como suas narrativas influenciaram suas ideias políticas e filosóficas, em particular a partir de comentários acerca do significado e do impacto de mudanças de última hora ao desfecho de Caleb Williams. Argumento que essa relação ambígua entre narrativa e política na obra de Godwin é relevante para reflexões políticas contemporâneas sobre a relação entre representação e ação política, ou como narrativas sobre a condição humana e realidades políticas podem afetas as ideias, atitudes e relações sociais de seus narradores.

  10. In conversation with: Professor Richard James

    Directory of Open Access Journals (Sweden)

    John Clarke

    2014-03-01

    Full Text Available In 2011, Richard James wrote in the Foreword to Nelson, Clarke, Kift, and Creagh’s (2012 monograph on Australasian literature on the First Year Experience that:The trend towards universal participation will usher in dramatic changes in the character of the first year in higher education. … (p. iiiIn an interview at the University of Melbourne, Australia in July 2013 between Richard James and John Clarke, Co-editor of the International Journal of the First Year in Higher Education, these and related issues were explored.  The interview picks up where the Foreword left off:  focussing on universal participation.

  11. 76 FR 18715 - Prince William Sound Resource Advisory Committee

    Science.gov (United States)

    2011-04-05

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource Advisory... meeting is open to the public. The following business will be conducted: The Prince William Sound Resource...

  12. James Watt's Leicester Walk

    OpenAIRE

    Bell, Kathleen

    2016-01-01

    a poem in which James Watt, inventor of the separate condenser, walks through contemporary Leicester (his route is from Bonners Lane and alongside the canal, taking in the Statue of Liberty on its traffic island near Sage Road). It is derived from the exercise of taking a character for a walk,

  13. James Bay Development Corporation annual report, 1986. Societe de Developpement de la Baie James et entites affiliees rapport annuel, 1986

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    The James Bay Development Corporation is a paragovernmental body whose objective is to promote the development and exploitation of those natural resources, other than hydroelectric, which are found in the James Bay region of Quebec. It also oversees the administration and infrastructure management in the territory. This report reviews the year's activities of the Corporation and its affiliates involved in tourism, native development, mining, and municipal affairs. Most of the report consists of financial statements.

  14. Hoarding symptoms among psychiatric outpatients: confirmatory factor analysis and psychometric properties of the Saving Inventory – Revised (SI-R

    Directory of Open Access Journals (Sweden)

    Siau Pheng Lee

    2016-10-01

    Full Text Available Abstract Background The growing interest in problematic hoarding as an independent clinical condition has led to the development of the Saving Inventory-Revised (SI-R to assess hoarding phenomenology. The SI-R is one of the most widely used instruments to measure hoarding symptoms; however, it lacks validation in non-Western samples. Methods The current study examined the construct, convergent, and discriminant validity of the SI-R among 500 outpatients at a psychiatric hospital in Singapore. The three-factor structure solution of the SI-R was fitted in a confirmatory factor analysis. Results The final model achieved mediocre fit (χ2 = 1026.02, df = 186; RMSEA = 0.095, SRMR = 0.06; CFI = 0.86; NNFI = 0.85. Two reverse-coded items (items 2 and 4 were removed due to insufficient factor loadings, resulting in the modified 21-item SI-R (SIR-21. Our findings indicate the need to further examine the construct validity of the SI-R, particularly in non-Western samples. Nonetheless, correlations with other hoarding-related constructs, such as anxiety (Beck Anxiety Inventory and depression (Beck Depression Inventory-II, supported the convergent and discriminant validity of the SIR-21 in our sample. Conclusions Findings in our current majority Chinese sample were consistent with previous observations from other Chinese samples. Implications were discussed from a cross-cultural perspective, such as cultural emphasis on saving for future use and overlap between the concepts of discarding and acquiring in Chinese samples. Future studies should also examine differences among other ethnic groups (e.g., Malay, Indian.

  15. Sustainable development in the Hudson Bay/James Bay bioregion

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    An overview is presented of projects planned for the James Bay/Hudson Bay region, and the expected environmental impacts of these projects. The watershed of James Bay and Hudson Bay covers well over one third of Canada, from southern Alberta to central Ontario to Baffin Island, as well as parts of north Dakota and Minnesota in the U.S.A. Hydroelectric power developments that change the timing and rate of flow of fresh water may cause changes in the nature and duration of ice cover, habitats of marine mammals, fish and migratory birds, currents into and out of Hudson Bay/James Bay, seasonal and annual loads of sediments and nutrients to marine ecosystems, and anadromous fish populations. Hydroelectric projects are proposed for the region by Quebec, Ontario and Manitoba. In January 1992, the Canadian Arctic Resources Committee (CARC), the Environmental Committee of Sanikuluaq, and the Rawson Academy of Arctic Science will launch the Hudson Bay/James Bay Bioregion Program, an independent initiative to apply an ecosystem approach to the region. Two main objectives are to provide a comprehensive assessment of the cumulative impacts of human activities on the marine and freshwater ecosystems of the Hudson Bay/James Bay bioregion, and to foster sustainable development by examining and proposing cooperative processes for decision making among governments, developers, aboriginal peoples and other stakeholders. 1 fig

  16. Williams propylene upgrading

    Energy Technology Data Exchange (ETDEWEB)

    Chappell, D. [Williams Energy Canada Inc., Edmonton, AB (Canada)

    2004-07-01

    Edmonton-based Williams Energy Canada Inc. extracts petrochemicals from oil sands and operates a straddle plant business and an olefins business. This presentation provided an update of both businesses and reviewed the advantage of polypropylene production in Alberta, with reference to premium markets and to comparative rail costs to Chicago via Texas, and rail costs to Chicago from Alberta. Williams' straddle plant business includes the Cochrane Straddle Plant, the Empress 2 Straddle Plant, and the Empress 5 Straddle Plant. The Fort McMurray Extraction Plant was also described along with the Redwater Olefins Fractionator and its potential for salt cavern storage and distribution. It was noted that Alberta is well positioned for polypropylene production because it already has a secure supply and an excellent distribution network. tabs., figs.

  17. Williams propylene upgrading

    International Nuclear Information System (INIS)

    Chappell, D.

    2004-01-01

    Edmonton-based Williams Energy Canada Inc. extracts petrochemicals from oil sands and operates a straddle plant business and an olefins business. This presentation provided an update of both businesses and reviewed the advantage of polypropylene production in Alberta, with reference to premium markets and to comparative rail costs to Chicago via Texas, and rail costs to Chicago from Alberta. Williams' straddle plant business includes the Cochrane Straddle Plant, the Empress 2 Straddle Plant, and the Empress 5 Straddle Plant. The Fort McMurray Extraction Plant was also described along with the Redwater Olefins Fractionator and its potential for salt cavern storage and distribution. It was noted that Alberta is well positioned for polypropylene production because it already has a secure supply and an excellent distribution network. tabs., figs

  18. Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions

    Directory of Open Access Journals (Sweden)

    Christian eLinke

    2013-07-01

    Full Text Available The Forkhead box family of transcription factors is evolutionary conserved from yeast to higher eukaryotes and its members are involved in many physiological processes including metabolism, DNA repair, cell cycle, stress resistance, apoptosis and aging. In budding yeast, four Forkhead transcription factors were identified, namely Fkh1, Fkh2, Fhl1, and Hcm1, which are implicated in chromatin silencing, cell cycle regulation and stress response. These factors impinge transcriptional regulation during cell cycle progression, and histone deacetylases play an essential role in this process, e.g. the nuclear localisation of Hcm1 depends on Sir2 activity, whereas Sin3/Rpd3 silence cell cycle specific gene transcription in G2/M phase. However, a direct involvement of Sir2 in Fkh1/Fkh2-dependent regulation of target genes is at present unknown. Here, we show that Fkh1 and Fkh2 associate with Sir2 in G1 and M phase, and that Fkh1/Fkh2-mediated activation of reporter genes is antagonized by Sir2. We further report that Sir2 overexpression strongly affects cell growth in an Fkh1/Fkh2-dependent manner. In addition, Sir2 regulates the expression of the mitotic cyclin Clb2 through Fkh1/Fkh2-mediated binding to the CLB2 promoter in G1 and M phase. We finally demonstrate that Sir2 is also enriched at the CLB2 promoter under stress conditions, and that the nuclear localization of Sir2 is dependent on Fkh1 and Fkh2. Taken together, our results show a functional interplay between Fkh1/Fkh2 and Sir2 suggesting a novel mechanism of cell cycle repression. Thus, in budding yeast, not only the regulation of G2/M gene expression but also the protective response against stress could be directly coordinated by Fkh1 and Fkh2.

  19. James Madison High School. A Curriculum for American Students.

    Science.gov (United States)

    Bennett, William J.

    This document presents the Secretary of Education's personal concept of a sound secondary school core curriculum. It is called "James Madison High School" in honor of President James Madison and his strong views that the people, in order to govern properly, must arm themselves with knowledge. The theoretical curriculum consists of four…

  20. Williams-Beuren's Syndrome: A Case Report.

    Science.gov (United States)

    Zamani, Hassan; Babazadeh, Kazem; Fattahi, Saeid; Mokhtari-Esbuie, Farzad

    2012-01-01

    Williams-Beuren syndrome is a rare familial multisystem disorder occurring in 1 per 20,000 live births. It is characterized by congenital heart defects (CHD), skeletal and renal anomalies, cognitive disorder, social personality disorder and dysmorphic facies. We present a case of Williams syndrome that presented to us with heart murmur and cognitive problem. A 5-year-old girl referred to pediatric cardiologist because of heart murmurs. She had a systolic murmur (2-3/6) in right upper sternal border with radiation to right cervical region. She also had a bulge forehead. Angiography showed mild supra valvular aortic stenosis and mild multiple peripheral pulmonary stenosis. Fluorescent in situ hybridization (FISH) was performed and the result was: 46.XX, ish del (7q11.2) (ELN X1) (7q22 X2) ELN deletion compatible with Williams syndrome. Peripheral pulmonary artery stenosis is associated with Noonan syndrome, Alagille syndrome, Cutis laxa, Ehler-Danlos syndrome, and Silver-Russel syndrome. The patient had peripheral pulmonary artery stenosis, but no other signs of these syndromes were present, and also she had a supravalvular aortic stenosis which was not seen in other syndromes except Williams syndrome. Conclusion. According to primary symptoms, paraclinical and clinical finding such as dysmorphic facies, cognitive disorder and congenital heart defect, Williams syndrome was the first diagnosis. We suggest a more attention for evaluating heart murmur in childhood period, especially when the patient has abnormal facial features or mental problem.

  1. Williams-Beuren's Syndrome: A Case Report

    Directory of Open Access Journals (Sweden)

    Hassan Zamani

    2012-01-01

    Full Text Available Williams-Beuren syndrome is a rare familial multisystem disorder occurring in 1 per 20,000 live births. It is characterized by congenital heart defects (CHD, skeletal and renal anomalies, cognitive disorder, social personality disorder and dysmorphic facies. We present a case of Williams syndrome that presented to us with heart murmur and cognitive problem. A 5-year-old girl referred to pediatric cardiologist because of heart murmurs. She had a systolic murmur (2-3/6 in right upper sternal border with radiation to right cervical region. She also had a bulge forehead. Angiography showed mild supra valvular aortic stenosis and mild multiple peripheral pulmonary stenosis. Fluorescent in situ hybridization (FISH was performed and the result was: 46.XX, ish del (7q11.2 (ELN X1 (7q22 X2 ELN deletion compatible with Williams syndrome. Peripheral pulmonary artery stenosis is associated with Noonan syndrome, Alagille syndrome, Cutis laxa, Ehler-Danlos syndrome, and Silver-Russel syndrome. The patient had peripheral pulmonary artery stenosis, but no other signs of these syndromes were present, and also she had a supravalvular aortic stenosis which was not seen in other syndromes except Williams syndrome. Conclusion. According to primary symptoms, paraclinical and clinical finding such as dysmorphic facies, cognitive disorder and congenital heart defect, Williams syndrome was the first diagnosis. We suggest a more attention for evaluating heart murmur in childhood period, especially when the patient has abnormal facial features or mental problem.

  2. Aerial photographic water color variations from pollution in the James River

    Science.gov (United States)

    Bressette, W. E.

    1978-01-01

    A photographic flight was made over the James River on May 17, 1977. The data show that, in general, James River water has very high sunlight reflectance. In the Bailey Bay area this reflectance is drastically reduced. Also shown is a technique for normalizing off-axis variations in radiance film exposure from camera falloff and uneven sunlight conditions to the nadir value. After data normalization, a spectral analysis is performed that identifies Bailey Creek water in James River water. The spectral results when compared with laboratory spectrometer data indicate that reflectance from James River water is dominated by suspended matter, while the substance most likely responsible for reduced reflectance in Bailey Creek water is dissolved organic carbon.

  3. American views of Sir Victor Horsley in the era of Cushing.

    Science.gov (United States)

    Lehner, Kurt R; Schulder, Michael

    2018-03-09

    Sir Victor Horsley was a pioneering British neurosurgeon known for his numerous neurosurgical, scientific, and sociopolitical contributions. Although word of these surgical and scientific achievements quickly spread throughout Europe and North America in the late 19th century, much of modern neurosurgery's view of Horsley has been colored by a single anecdote from John Fulton's biography of Harvey Cushing. In this account, Cushing observes a frenetic Horsley hastily removing a Gasserian ganglion from a patient in the kitchen of a British mansion. Not long after, Cushing left Britain saying that he had little to learn from British neurosurgery. The authors of this paper examined contemporary views of Horsley to assess what his actual reputation was in the US and Canada. The authors conducted a thorough search of references to Horsley using the following sources: American surgical and neurosurgical textbooks; major biographies; diary entries and letters; PubMed; newspaper articles; and surgical and neurosurgical texts. The positive reception of his work is corroborated by invitations for Horsley to speak in America. Research additionally revealed that Horsley had numerous personal and professional relationships with prominent Americans in medicine, including William Osler, John Wheelock Elliot, Ernest Sachs, and (yes) Harvey Cushing. Horsley's contributions to medicine and science were heavily reported in American newspapers; outside of neurosurgery, his strong opposition to the antivivisectionists and his support for alcohol prohibition were widely reported in popular media. Horsley's contributions to neurosurgery in America are undeniable. Writings from and about prominent Americans reveal that he was viewed favorably by those who had met him. Frequent publication of his views in the American media suggests that medical professionals and the public in the US valued his contributions on scientific as well as social issues. Horsley died too young, but not without the

  4. How James Wood Works

    Science.gov (United States)

    Goldstein, Evan R., Comp.

    2008-01-01

    Reading through news-media clippings about James Wood, one might reasonably conclude that "pre-eminent critic" is his official job title. In fact, Wood is a staff writer for "The New Yorker" and a professor of the practice of literary criticism at Harvard University. But at a time when there is much hand-wringing about the death of the…

  5. James B. Macdonald: A Bibliography.

    Science.gov (United States)

    Brubaker, Dale L., Comp.; Brookbank, Gayle, Comp.

    1986-01-01

    Presents a bibliography of James B. Macdonald's writings and printed speeches arranged chronologically according to the educator's themes of inquiry. Macdonald's videotaped autobiography identifies four explorative stages: (1) Scientism, (2) person-centered humanism, (3) sociopolitical humanism, and (4) transcendentalism, signaling a need for…

  6. SIR - small is safe [in reactor design

    International Nuclear Information System (INIS)

    Hayns, M.

    1989-01-01

    A joint USA-UK venture has been initiated to design a small nuclear reactor which offers low capital cost, greater flexibility and a potentially lower environmental impact. Called Safe Integral Reactor (SIR), the lead unit could be built in the United Kingdom Atomic Energy Authority's (UKAEA's) Winfrith site if the design is accepted by the UK Nuclear Installations Inspectorate (NII). This article describes the 320 MWe reactor unit that is the basis of the design being developed. (author)

  7. Analysis of data acquired by Shuttle Imaging Radar SIR-A and Landsat Thematic Mapper over Baldwin County, Alabama

    Science.gov (United States)

    Wu, S.-T.

    1985-01-01

    Seasonally compatible data collected by SIR-A and by Landsat 4 TM over the lower coastal plain in Alabama were coregistered, forming a SIR-A/TM multichannel data set with 30 m x 30 m pixel size. Spectral signature plots and histogram analysis of the data were used to observe data characteristics. Radar returns from pine forest classes correlated highly with the tree ages, suggesting the potential utility of microwave remote sensing for forest biomass estimation. As compared with the TM-only data set, the use of SIR-A/TM data set improved classification accuracy of the seven land cover types studied. In addition, the SIR-A/TM classified data support previous finding by Engheta and Elachi (1982) that microwave data appear to be correlated with differing bottomland hardwood forest vegetation as associated with varying water regimens (i.e., wet versus dry).

  8. SIRS score on admission and initial concentration of IL-6 as severe acute pancreatitis outcome predictors.

    Science.gov (United States)

    Gregoric, Pavle; Pavle, Gregoric; Sijacki, Ana; Ana, Sijacki; Stankovic, Sanja; Sanja, Stankovic; Radenkovic, Dejan; Dejan, Radenkovic; Ivancevic, Nenad; Nenad, Ivancevic; Karamarkovic, Aleksandar; Aleksandar, Karamarkovic; Popovic, Nada; Nada, Popovic; Karadzic, Borivoje; Borivoje, Karadzic; Stijak, Lazar; Stefanovic, Branislav; Branislav, Stefanovic; Milosevic, Zoran; Zoran, Milosević; Bajec, Djordje; Djordje, Bajec

    2010-01-01

    Early recognition of severe form of acute pancreatitis is important because these patients need more agressive diagnostic and therapeutical approach an can develope systemic complications such as: sepsis, coagulopathy, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Dysfunction Syndrome (MODS), Multiple Organ Failure (MOF). To determine role of the combination of Systemic Inflammatory Response Syndrome (SIRS) score and serum Interleukin-6 (IL-6) level on admission as predictor of illness severity and outcome of Severe Acute Pancreatitis (SAP). We evaluated 234 patients with first onset of SAP appears in last twenty four hours. A total of 77 (33%) patients died. SIRS score and serum IL-6 concentration were measured in first hour after admission. In 105 patients with SIRS score 3 and higher, initial measured IL-6 levels were significantly higher than in the group of remaining 129 patients (72 +/- 67 pg/mL, vs 18 +/- 15 pg/mL). All nonsurvivals were in the first group, with SIRS score 3 and 4 and initial IL-6 concentration 113 +/- 27 pg/mL. The values of C-reactive Protein (CRP) measured after 48h, Acute Physiology and Chronic Health Evaluation (APACHE II) score on admission and Ranson score showed the similar correlation, but serum amylase level did not correlate significantly with Ranson score, IL-6 concentration and APACHE II score. The combination of SIRS score on admission and IL-6 serum concentration can be early, predictor of illness severity and outcome in SAP.

  9. William Wilde: Historian.

    Science.gov (United States)

    Geary, L

    2016-05-01

    This essay attempts to assess William Wilde as a social historian. It examines some of his contributions to the discipline of history and looks particularly at 'The food of the Irish', which was published in the Dublin University Magazine in February 1854.

  10. Language and Communicative Development in Williams Syndrome

    Science.gov (United States)

    Mervis, Carolyn B.; Becerra, Angela M.

    2007-01-01

    Williams syndrome, a genetic disorder caused by a microdeletion of approximately 25 genes on chromosome 7q11.23, is associated with mild to moderate intellectual disability or learning difficulties. Most individuals with Williams syndrome evidence a cognitive profile including relative strengths in verbal short-term memory and language, and…

  11. 75 FR 39910 - Prince William Sound Resource Advisory Committee; Meeting

    Science.gov (United States)

    2010-07-13

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee; Meeting AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource..., Anchorage, Alaska 99503. Send written comments to Prince William Sound Resource Advisory Committee, c/o USDA...

  12. Social Cognition in Williams Syndrome: Face Tuning.

    Science.gov (United States)

    Pavlova, Marina A; Heiz, Julie; Sokolov, Alexander N; Barisnikov, Koviljka

    2016-01-01

    Many neurological, neurodevelopmental, neuropsychiatric, and psychosomatic disorders are characterized by impairments in visual social cognition, body language reading, and facial assessment of a social counterpart. Yet a wealth of research indicates that individuals with Williams syndrome exhibit remarkable concern for social stimuli and face fascination. Here individuals with Williams syndrome were presented with a set of Face-n-Food images composed of food ingredients and in different degree resembling a face (slightly bordering on the Giuseppe Arcimboldo style). The primary advantage of these images is that single components do not explicitly trigger face-specific processing, whereas in face images commonly used for investigating face perception (such as photographs or depictions), the mere occurrence of typical cues already implicates face presence. In a spontaneous recognition task, participants were shown a set of images in a predetermined order from the least to most resembling a face. Strikingly, individuals with Williams syndrome exhibited profound deficits in recognition of the Face-n-Food images as a face: they did not report seeing a face on the images, which typically developing controls effortlessly recognized as a face, and gave overall fewer face responses. This suggests atypical face tuning in Williams syndrome. The outcome is discussed in the light of a general pattern of social cognition in Williams syndrome and brain mechanisms underpinning face processing.

  13. A new case of keratoconus associated with Williams-Beuren syndrome.

    Science.gov (United States)

    Viana, Melissa Machado; Frasson, Maria; Leão, Letícia Lima; Stofanko, Martin; Gonçalves-Dornelas, Higgor; Cunha, Pricila da Silva; de Aguiar, Marcos José Burle

    2013-09-01

    Williams-Beuren syndrome is a multisystemic genetic disorder caused by a contiguous gene deletion at 7q11.23. Keratoconus is a complex disease and it is suspected to have a genetic origin, although the specific gene responsible for keratoconus has not been identified. Although there are several ocular features in Williams-Beuren syndrome, keratoconus is not regularly described as part of this syndrome. To report a new patient with keratoconus and Williams-Beuren syndrome. This is the third case of an association between Williams-Beuren syndrome and keratoconus. The authors believe that the Williams-Beuren syndrome chromosome region can be a possible target for further investigation as the genetic basis of keratoconus.

  14. Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination.

    Directory of Open Access Journals (Sweden)

    Alison E Ringel

    Full Text Available Sir2 is an NAD(+-dependent histone deacetylase required to mediate transcriptional silencing and suppress rDNA recombination in budding yeast. We previously identified Tdh3, a glyceraldehyde 3-phosphate dehydrogenase (GAPDH, as a high expression suppressor of the lethality caused by Sir2 overexpression in yeast cells. Here we show that Tdh3 interacts with Sir2, localizes to silent chromatin in a Sir2-dependent manner, and promotes normal silencing at the telomere and rDNA. Characterization of specific TDH3 alleles suggests that Tdh3's influence on silencing requires nuclear localization but does not correlate with its catalytic activity. Interestingly, a genetic assay suggests that Tdh3, an NAD(+-binding protein, influences nuclear NAD(+ levels; we speculate that Tdh3 links nuclear Sir2 with NAD(+ from the cytoplasm.

  15. Epistemologia pragmatyczna Michaela Williamsa (PRAGMATIST EPISTEMOLOGY BY MICHAEL WILLIAMS

    Directory of Open Access Journals (Sweden)

    Renata Ziemińska

    2007-06-01

    Full Text Available The article presents three main elements of Williams' epistemology: the concept of knowledge, the problem of skepticism and the concept of truth. Williams takes knowledge not as pure descriptive but partly normative concept (to know is to be engaged and entitled. He rejects the demonstrative conception of knowledge (knowledge is infallible and prefers the fallibilist conception of knowledge (knowledge is uncertain and fallible. Williams is good at bringing skeptical presuppositions to light: the demonstrative conception of knowledge and the conception of justification with Prior Grounding Requirement, epistemological realism and priority for internal knowledge. He rightly observes that when we change that presuppositions (skeptic's context, knowledge does exist. However, Williams-fallibilist is close to a skeptic: they both agree that our beliefs are uncertain. The difference is only whether some of our beliefs deserve to be called knowledge. The most important worries concern Williams' concept of truth (deflationary pragmatism. According to Williams truth has no nature and it is not a goal of inquiry. However, if truth is not a goal, we can hardly understand the previous discussion with skepticism and the defense of rationality.

  16. Investigating The Travelling Wave Solution For an SIR Endemic ...

    African Journals Online (AJOL)

    This paper presents the travelling wave solution for an SIR endemic disease model with no disease related death when the spatial spread of the susceptible is not negligible. In this case the disease is driven by both the susceptible and the infective classes. The population is open since the disease is habitually prevalent in ...

  17. Science and controversy a biography of Sir Norman Lockyer

    CERN Document Server

    Meadows, A

    2008-01-01

    Sir Norman Lockyer left Nature, the world''s leading scientific journal, as his lasting memorial. But his life, and controversial theories, are an important part of science history. His ideas were at the forefront of public debate, and ranged from brilliant to perverse. This entertaining book is a fascinating insight into his eventful life

  18. The inauguration of Robert-Bourassa Park at James Bay

    International Nuclear Information System (INIS)

    Valiquette, M.

    1997-01-01

    Robert Bourassa's contributions to the hydroelectric development at James Bay were acknowledged with the inauguration of a park in the ex-prime minister's name. Phase 1 of the James Bay hydroelectric project constituted the world's biggest construction site, employing more than 180,000 people from beginning to project completion. The James Bay project allowed Hydro-Quebec to gain one of the world's largest electric power utilities and to gain significant competitive edge over its competitors. The Robert Bourassa Park contains a picnic area and a visitor interpretation centre which describes the history of the project. A sequence of 5 signposts summarize the contributions that Robert Bourassa made to the megaproject which cost over $20.6 billion. The complex consists of 65 turbines which produce 15,235 megawatts of electricity. 1 fig

  19. From James Hutton’s «Theory of the Earth» to James Lovelock’s «Gaia Hypothesis»

    Directory of Open Access Journals (Sweden)

    García Cruz, Cándido Manuel

    2007-06-01

    Full Text Available In order to understand to what extent James Hutton (1726-1797 can in fact be considered as one of the first forerunners of the Gaia Hypothesis, his Theory of the Earth is analysed into context
    of the three basic traditions of science: organismic, magical and mechanistic. In the some authors’ opinion, Hutton should have written in his theory the Earth was a superorganism and its proper
    study should be by physiology. These supposed assertions are merely a misinterpretation of the Huttonian philosophy, since were never held by this author. Hutton has nevertheless an holistic view which is closer to the Alfred N. Whitehead's organic mechanicism than the James Lovelock's
    Gaia Hypothesis, being therefore a clear forerunner of Ludwig von Bertalanffy and his System
    General Theory.

    Para comprender en qué medida James Hutton (1726-1797 puede ser considerado en realidad como uno de los primeros precursores de la Hipótesis Gaia, se analiza su Theory of the Earth en el contexto de las tres tradiciones básicas de la ciencia: la organísmica, la mágica y la mecanicista. Para algunos autores, Hutton habría sugerido en su teoría que la tierra era un superorganismo y que la forma más correcta para estudiarla era la fisiología. Estas supuestas afirmaciones son simplemente una interpretación errónea del pensamiento huttoniano, puesto que este autor nunca las hizo. Sin embargo, Hutton posee de hecho una visión holística que está más próxima al mecanicismo orgánico de Alfred N. Whitehead que a la Hipótesis Gaia de James Lovelock, siendo por tanto un claro precursor de Ludwig von Bertalanffy y su Teoría General de Sistemas.

  20. 33 CFR 161.60 - Vessel Traffic Service Prince William Sound.

    Science.gov (United States)

    2010-07-01

    ... William Sound. 161.60 Section 161.60 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Movement Reporting System Areas and Reporting Points § 161.60 Vessel Traffic Service Prince William Sound... Cape Hinchinbrook Light to Schooner Rock Light, comprising that portion of Prince William Sound between...

  1. Buffels (Wes), Elsies, Sir Lowry's pass, Steenbras and Buffels (Oos)

    CSIR Research Space (South Africa)

    Heinecken, TJE

    1982-06-01

    Full Text Available This report is a synthesis of all available information on five of the smaller rivers discharging in to False bay combined as a single volume. The rivers dealt with are the Buffels (Wes), Elsies, Sir Lowry' Pass, Steenbras and Buffels (Oos). False...

  2. Skin findings in Williams syndrome.

    Science.gov (United States)

    Kozel, Beth A; Bayliss, Susan J; Berk, David R; Waxler, Jessica L; Knutsen, Russell H; Danback, Joshua R; Pober, Barbara R

    2014-09-01

    Previous examination in a small number of individuals with Williams syndrome (also referred to as Williams-Beuren syndrome) has shown subtly softer skin and reduced deposition of elastin, an elastic matrix protein important in tissue recoil. No quantitative information about skin elasticity in individuals with Williams syndrome is available; nor has there been a complete report of dermatologic findings in this population. To fill this knowledge gap, 94 patients with Williams syndrome aged 7-50 years were recruited as part of the skin and vascular elasticity (WS-SAVE) study. They underwent either a clinical dermatologic assessment by trained dermatologists (2010 WSA family meeting) or measurement of biomechanical properties of the skin with the DermaLab™ suction cup (2012 WSA family meeting). Clinical assessment confirmed that soft skin is common in this population (83%), as is premature graying of the hair (80% of those 20 years or older), while wrinkles (92%), and abnormal scarring (33%) were detected in larger than expected proportions. Biomechanical studies detected statistically significant differences in dP (the pressure required to lift the skin), dT (the time required to raise the skin through a prescribed gradient), VE (viscoelasticity), and E (Young's modulus) relative to matched controls. The RT (retraction time) also trended longer but was not significant. The biomechanical differences noted in these patients did not correlate with the presence of vascular defects also attributable to elastin insufficiency (vascular stiffness, hypertension, and arterial stenosis) suggesting the presence of tissue specific modifiers that modulate the impact of elastin insufficiency in each tissue. © 2014 Wiley Periodicals, Inc.

  3. Op zoek naar James Bond: media-pelgrimages, fans en masculiniteit

    NARCIS (Netherlands)

    Reijnders, S.

    2009-01-01

    Visiting the settings of popular films and tv series has become a growing niche in the tourist market. Little is known about what makes these visits so appealing. This question is explored on the basis of the case of James Bond. Twenty-three interviews were conducted with James Bond fans who had

  4. James Joyce kui religiooni subjekt ja objekt / Kalle Käsper

    Index Scriptorium Estoniae

    Käsper, Kalle, 1952-

    2003-01-01

    Arvustus: Joyce, James. Dublinlased : [novellid] / inglise keelest tõlkinud Jaak Rähesoo. 2. tr. [Tallinn] : Varrak, 2003 ; Joyce, James. Kunstniku noorpõlveportree : [romaan] / inglise keelest tõlkinud [ja järelsõna:] Jaak Rähesoo. [Tallinn] : Varrak, 2003; vt ka vastukaja: Raudam, Toomas. Kontra Käsper // Sirp (2003) 20. juuni, lk. 5

  5. Simulation of emotional contagion using modified SIR model: A cellular automaton approach

    Science.gov (United States)

    Fu, Libi; Song, Weiguo; Lv, Wei; Lo, Siuming

    2014-07-01

    Emotion plays an important role in the decision-making of individuals in some emergency situations. The contagion of emotion may induce either normal or abnormal consolidated crowd behavior. This paper aims to simulate the dynamics of emotional contagion among crowds by modifying the epidemiological SIR model to a cellular automaton approach. This new cellular automaton model, entitled the “CA-SIRS model”, captures the dynamic process ‘susceptible-infected-recovered-susceptible', which is based on SIRS contagion in epidemiological theory. Moreover, in this new model, the process is integrated with individual movement. The simulation results of this model show that multiple waves and dynamical stability around a mean value will appear during emotion spreading. It was found that the proportion of initial infected individuals had little influence on the final stable proportion of infected population in a given system, and that infection frequency increased with an increase in the average crowd density. Our results further suggest that individual movement accelerates the spread speed of emotion and increases the stable proportion of infected population. Furthermore, decreasing the duration of an infection and the probability of reinfection can markedly reduce the number of infected individuals. It is hoped that this study will be helpful in crowd management and evacuation organization.

  6. Discoverers of the universe William and Caroline Herschel

    CERN Document Server

    Hoskin, Michael

    2011-01-01

    Discoverers of the Universe tells the gripping story of William Herschel, the brilliant, fiercely ambitious, emotionally complex musician and composer who became court astronomer to Britain's King George III, and of William's sister, Caroline, who assisted him in his observations of the night sky and became an accomplished astronomer in her own right. Together, they transformed our view of the universe from the unchanging, mechanical creation of Newton's clockmaker god to the ever-evolving, incredibly dynamic cosmos that it truly is. William was in his forties when his amateur observations usi

  7. Conference James F.Buckli

    CERN Multimedia

    Buckli,J

    1988-01-01

    L'association du personnel a le plaisir d'accueillir Mons. James F.Buckli, astronaute, né en 1947. Il a participé à la mission Space Lab D1 qui pour la première fois mettait 8 personnes sur orbite.L'ass.du pers. remercie aussi Gordon White(s) de la mission américaine d'avoir permis d'organiser cette conférence

  8. The Octopus, the Squid and the Tortoise

    Science.gov (United States)

    Caruth, Gail D.; Caruth, Donald L.

    2013-01-01

    What is the role of the Doctor of Philosophy (PhD) today? This is not a new question. In 1903, William James questioned the value of the degree as an indicator of teaching ability. Unfortunately, the issue James raised has never been resolved. Move forward in time to 1990. Theodore Ziolkowski essentially agreed with James, but raised additional…

  9. Clear as Crystal: The Story of the Braggs--How X-Ray Crystallography Has Contributed to Science

    Science.gov (United States)

    George, Robert; Patterson, John

    2014-01-01

    Here is a brief history of the work of two of Australia's most famous scientists, Sir William Bragg and his son Sir Lawrence Bragg. Jointly awarded the Nobel Prize in 1915 for their groundbreaking research into the use of X-rays to study the chemical structure and function of molecules, they have contributed to our heritage and to science at an…

  10. Le continent noir du désir masculin : Colet et Flaubert, encore

    OpenAIRE

    Vinken, Barbara

    2010-01-01

    Il y a peu d’échanges de lettres qui surprennent le lecteur aussi douloureusement que celui entre Louise Colet et Gustave Flaubert. Rarement, l’espoir qui sommeille au fond de tout lecteur d’une histoire d’amour heureux fut à ce point frustré.Les études de Freud – un des plus grands sceptiques en matière d’amour – sur la vie sexuelle éclairent les vicissitudes du désir amoureux masculin. Les Lettres de Flaubert à Colet sont la mise en scène dramatique d’un désir qui suit les complications du ...

  11. Investigating the ''social brain'' through Williams syndrome

    International Nuclear Information System (INIS)

    Nagamine, Masanori; Mimura, Masaru; Reiss, A.L.; Hoeft, F.

    2010-01-01

    Recent advances in social cognitive neuroscience have led to the concept of the ''social brain''. The social brain includes neural processes specialized for processing social information necessary for the recognition of self and others, and interpersonal relationships. Because of its unique behavioral phenotypic features which includes 'hypersociability', Williams syndrome has gained popularity among social cognitive neuroscientists. Individuals with Williams syndrome share the same genetic risk factor for cognitive-behavioral dysfunction utilizing brain imaging to elucidate endophenotype provides us with an unprecendented opportunity to study gene, brain and behavior relationships especially those related to social cognition. In this review, we provide an overview of neuroimaging studies on social cognition in Williams syndrome and discuss the neural basis of the social brain. (author)

  12. The William and Flora Hewlett Foundation | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The William and Flora Hewlett Foundation. The William and Flora Hewlett Foundation. http://www.hewlett.org/. Think Tank Initiative. This initiative is creating high-quality independent research and policy institutions throughout the developing world. View more. Think Tank Initiative. Growth and Economic Opportunities for ...

  13. Mental Health Problems in Adults with Williams Syndrome

    Science.gov (United States)

    Stinton, Chris; Elison, Sarah; Howlin, Patricia

    2010-01-01

    Although many researchers have investigated emotional and behavioral difficulties in individuals with Williams syndrome, few have used standardized diagnostic assessments. We examined mental health problems in 92 adults with Williams syndrome using the Psychiatric Assessment Schedule for Adults with Developmental Disabilities--PAS-ADD (Moss,…

  14. 34 CFR 685.100 - The William D. Ford Federal Direct Loan Program.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false The William D. Ford Federal Direct Loan Program. 685...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION WILLIAM D. FORD FEDERAL DIRECT LOAN PROGRAM Purpose and Scope § 685.100 The William D. Ford Federal Direct Loan Program. (a) Under the William D. Ford...

  15. Congenital heart defects in Williams syndrome.

    Science.gov (United States)

    Yuan, Shi-Min

    2017-01-01

    Yuan SM. Congenital heart defects in Williams syndrome. Turk J Pediatr 2017; 59: 225-232. Williams syndrome (WS), also known as Williams-Beuren syndrome, is a rare genetic disorder involving multiple systems including the circulatory system. However, the etiologies of the associated congenital heart defects in WS patients have not been sufficiently elucidated and represent therapeutic challenges. The typical congenital heart defects in WS were supravalvar aortic stenosis, pulmonary stenosis (both valvular and peripheral), aortic coarctation and mitral valvar prolapse. The atypical cardiovascular anomalies include tetralogy of Fallot, atrial septal defects, aortic and mitral valvular insufficiencies, bicuspid aortic valves, ventricular septal defects, total anomalous pulmonary venous return, double chambered right ventricle, Ebstein anomaly and arterial anomalies. Deletion of the elastin gene on chromosome 7q11.23 leads to deficiency or abnormal deposition of elastin during cardiovascular development, thereby leading to widespread cardiovascular abnormalities in WS. In this article, the distribution, treatment and surgical outcomes of typical and atypical cardiac defects in WS are discussed.

  16. Recent paleoseismicity record in Prince William Sound, Alaska, USA

    Science.gov (United States)

    Kuehl, Steven A.; Miller, Eric J.; Marshall, Nicole R.; Dellapenna, Timothy M.

    2017-12-01

    Sedimentological and geochemical investigation of sediment cores collected in the deep (>400 m) central basin of Prince William Sound, along with geochemical fingerprinting of sediment source areas, are used to identify earthquake-generated sediment gravity flows. Prince William Sound receives sediment from two distinct sources: from offshore (primarily Copper River) through Hinchinbrook Inlet, and from sources within the Sound (primarily Columbia Glacier). These sources are found to have diagnostic elemental ratios indicative of provenance; Copper River Basin sediments were significantly higher in Sr/Pb and Cu/Pb, whereas Prince William Sound sediments were significantly higher in K/Ca and Rb/Sr. Within the past century, sediment gravity flows deposited within the deep central channel of Prince William Sound have robust geochemical (provenance) signatures that can be correlated with known moderate to large earthquakes in the region. Given the thick Holocene sequence in the Sound ( 200 m) and correspondingly high sedimentation rates (>1 cm year-1), this relationship suggests that sediments within the central basin of Prince William Sound may contain an extraordinary high-resolution record of paleoseismicity in the region.

  17. BOREAS RSS-15 SIR-C and Landsat TM Biomass and Landcover Maps of the NSA

    Science.gov (United States)

    Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Ranson, K. Jon

    2000-01-01

    As part of BOREAS, the RSS-15 team conducted an investigation using SIR-C, X-SAR, and Landsat TM data for estimating total above-ground dry biomass for the SSA and NSA modeling grids and component biomass for the SSA. Relationships of backscatter to total biomass and total biomass to foliage, branch, and bole biomass were used to estimate biomass density across the landscape. The procedure involved image classification with SAR and Landsat TM data and development of simple mapping techniques using combinations of SAR channels. For the SSA, the SIR-C data used were acquired on 06-Oct-1994, and the Landsat TM data used were acquired on 02-Sep-1995. The maps of the NSA were developed from SIR-C data acquired on 13-Apr-1994. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  18. James Wallbank (Redundant Technology Initiative) (RTI) / James Wallbank ; interv. Tilman Baumgärtel

    Index Scriptorium Estoniae

    Wallbank, James

    2006-01-01

    James Wallbank (sünd. 1966) on RTI (Aegunud Tehnoloogia Initsiatiiv), mis hoiab alates 2000. aastast käigus Interneti-kohvikut "Access Space") Sheffieldis, rajaja. J. Wallbank 6. 10. 2000 tehtud intervjuus RTI-st, mis kasutab oma installatsioonides, skulptuurides ja teistes madaltehnoloogilistes teostes vanu arvuteid, installatsioonist näitusel "net_condition" Karlssruhe Kunsti- ja Meediatehnoloogia Keskuses (1999), tööst "Network Low Tech Video Wall" (2000) ja muust

  19. Emotional Responsivity in Young Children with Williams Syndrome

    Science.gov (United States)

    Fidler, Debbie J.; Hepburn, Susan L.; Most, David E.; Philofsky, Amy; Rogers, Sally J.

    2007-01-01

    The hypothesis that young children with Williams syndrome show higher rates of emotional responsivity relative to other children with developmental disabilities was explored. Performance of 23 young children with Williams syndrome and 30 MA-matched children with developmental disabilities of nonspecific etiologies was compared on an adaptation of…

  20. Malformations vasculaires au cours du syndrome de Williams ...

    African Journals Online (AJOL)

    Le syndrome de Williams-Beuren est une maladie génétique rare, il associe classiquement une dysmorphie faciale assez spécifique, des malformations cardiovasculaires et un profil neuropsychologique particulier. Nous rapportons les observations de trois enfants atteints du syndrome de Williams-Beuren en insistant ...

  1. The psychology and physiology of temperament: pragmatism in context.

    Science.gov (United States)

    Bordogna, F

    2001-01-01

    This paper traces William James's famous "temperament thesis" according to which the philosophical stance that individuals take depends on their "temperaments." It seeks to understand James's conception of temperament by locating James within a set of contemporary investigations that linked the sources of mental, and even higher, intellectual processes to the physiological and organic constitution of the individual. The paper argues that James understood temperament along the reflex-arc model and discusses the implications of that physiological account of temperament for James's overall conception of philosophy.

  2. William Carlos Williams’ cubism: The sensory dimension

    Directory of Open Access Journals (Sweden)

    J-L Kruger

    1995-05-01

    Full Text Available In this article the cubism of the American poet William Carlos Williams is discussed as a product of sensory elements combined with techniques derived from the work of the visual artists associated with this style. Through the study o f a number of poems written in the period between 1917 and 1923 it is shown that Williams employs the cubist intersection of sensory planes in particular to create a sensory dimension that not only renews the traditions and mode of poetry, but also reveals the cubist concern with the defamiliarization and foregrounding of fragments of everyday experiences. Ultimately the article is an attempt to indicate Williams’ incorporation o f a sensual dimension in creating a style that achieves modernist presentation revealing an independence from both traditional literary and visual styles.

  3. Quantitative measurement of Y90 brehmmstrahlung images after of Y90 Sir-Spheres implantation to assess lung shunting

    International Nuclear Information System (INIS)

    Forwood, Nicholas J.; Pocock, Nicholas; Shin, Jane; Young, Andy M; Szeto, Edwin R.

    2009-01-01

    Full text: Background: In clinical practice the dose of Y 9 0 Sir-Spheres is calculated using a pre injection of Tc 9 9 m MAA. There is however a potential difference due to the different properties of Tc 9 9 m MAA and Y 9 0 Sir-Spheres. We assessed the concordance of lung shunting of Y 9 0 Sir-Spheres estimated using Y 9 0 Bremsstrahlung imaging, compared to shunting assessed using Tc 9 9 m MAA. Methods: 15 Patients were evaluated using 150-200 MBq of Tc 9 9 m MAA injected into the hepatic artery under angiographic guidance. Whole body images were acquired using a LEAP collimator (window of 140 kEv+/-10%). The patients were subsequently treated with Y 9 0 Sir-Spheres. After microspheres injection, whole body brehmsstrahlung images were acquired using a medium energy collimator (window settings of 75 kEv +/- 20%). Tc 9 9 m MAA images were paired with their corresponding bremsstrahlung image and lung shunting in the stu ides calculated simultaneously. Each paired dataset was analyzed by 5 operators. Results: The mean lung shunting for Tc 9 9 m MAA acquisition was 3.32% (SD 2.03) which was significantly lower than the lung shunting using the Y 9 0 acquisitions: mean 16.19% (SD of 6.43). The Pearson coefficient was r = 0.62 (p 9 0 Sir-Spheres bremsstrahlung imaging is higher than that calculated by Tc 9 9 m MAA imaging. The relationship is not sufficiently strong to use bremsstahlung imaging to retrospectively quantify the lung-to-liver shunting as indicated using Tc 9 9 M AA. Further studies are underway to assess the reliability of Tc 9 9 m MAA lung uptake calculations in determining the dose of Y 9 0 Sir-Spheres.

  4. Infantile ictal apneas in a child with williams-beuren syndrome.

    Science.gov (United States)

    Myers, Kenneth A; McLeod, D Ross; Bello-Espinosa, Luis

    2013-02-01

    Williams-Beuren syndrome is a genetic disorder rarely associated with seizures. The few described cases of Williams-Beuren syndrome and epilepsy have primarily involved infantile spasms and deletions extending beyond the common deletion region for this disorder. We present the case of a 5-week-old child with ictal apneas and typical Williams-Beuren syndrome deletion. Diagnosis was challenging, because the child had cardiac, respiratory, and gastrointestinal abnormalities typically associated with Williams-Beuren syndrome, which are also associated with cyanotic episodes. The results of interictal electroencephalography were normal, illustrating that prolonged electroencephalography is often essential in evaluation of suspected ictal apneas. Seizure freedom was achieved with carbamazepine. Sudden death is seen in Williams-Beuren syndrome, and this case raises the question whether some of these cases may be related to ictal apneas and could potentially be preventable with appropriate pharmaceutical intervention. Copyright © 2013 Elsevier Inc. All rights reserved.

  5. Milestones in plant sulfur research on sulfur-induced-resistance (SIR in Europe

    Directory of Open Access Journals (Sweden)

    Elke eBloem

    2015-01-01

    Full Text Available Until the 1970´s of the last century sulfur (S was mainly regarded as a pollutant being the main contributor of acid rain, causing forest dieback in central Europe. When Clean Air Acts came into force at the start of the 1980´s SO2 contaminations in the air were consequently reduced within the next years. S changed from an unwanted pollutant into a lacking plant nutrient in agriculture since agricultural fields were no longer fertilized indirectly by industrial pollution. S deficiency was first noticed in Brassica crops that display an especially high S demand because of its content of S-containing secondary metabolites, the glucosinolates. In Scotland, where S depositions decreased even faster than in continental Europe, an increasing disease incidence with Pyrenopeziza brassicae was observed in oilseed rape in the beginning 1990´s and the concept of sulfur-induced-resistance (SIR was developed after a relationship between the S status and the disease incidence was uncovered. Since then a lot of research was carried out to unravel the background of SIR in the metabolism of agricultural crops and to identify metabolites, enzymes and reactions, which are potentially activated by the S metabolism to combat fungal pathogens. The S status of the crop is affecting many different plant features such as color and scent of flowers, pigments in leaves, metabolite concentrations and the release of gaseous S compounds which are directly influencing the desirability of a crop for a variety of different organisms from microorganisms, over insects and slugs to the point of grazing animals.The present paper is an attempt to sum up the knowledge about the effect of the S nutritional status of agricultural crops on parameters that are directly related to their health status and by this to SIR. Milestones in SIR research are compiled, open questions are addressed and future projections were developed.

  6. James Moir as Organic Chemist

    African Journals Online (AJOL)

    NICO

    James Moir (1874–1929) played an important role in the field of chemistry in South ... into the colour of organic compounds and the relationship be- tween colour ...... theory put forward by E.R.Watson,34 the depth of colour, or the displacement .... cover-glass, such as used in microscopy, to photograph absorp- tion bands ...

  7. Northern gas: Williams petrochemical feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Chappell, D. [Williams Energy Canada, Calgary, AB (Canada)

    2002-07-01

    Williams Energy is a company that is involved in the following fields: gas pipelines, exploration and production, midstream, refining, petrochemical, power, and marketing and trading. The author provides an overview of the global and Canadian infrastructure before proceeding to discuss Arctic gas, which is viewed by Williams Energy as necessary. It favors the Alaska Highway route with a consortium for project development. Williams performed a petrochemical study to determine the feasibility of a petrochemical complex utilizing natural gas liquid from an Arctic gas pipeline. The scope of the study encompassed facilities (extraction plant, cracker, polyolefins plant), size (world scale, approximately 2 billion pounds per year), and location (Fairbanks or Alberta). The study led to the following findings: (1) review of several scenarios for both locations, (2) complex to produce two grades of polyethylene, (3) feedstock cost favors Alaska, (4) construction costs lower in Alberta, (5) and the primary market for the Alaska complex would be northeast Asia, while the primary market for the Alberta location would be the United States. It was determined that both options would be viable, however Alberta was favored due to the polyethylene forecast. The challenges still being faced by Williams include low frac spread, market inefficiencies, empress volumes, carbon dioxide, and fuel and electricity cost. Each of these challenges is discussed separately. The author concludes by indicating that incremental ethane is available, carbon dioxide issues need resolution, and Alberta and Alaska are attractive for Arctic ethane petrochemical production. figs.

  8. Review of James L. Baughman, Jennifer Ratner-Rosenhagen, and James P. Danky, eds, Protest on the Page: Essays on Print and the Culture of Dissent since 1865 (2015

    Directory of Open Access Journals (Sweden)

    Maria Zirra

    2017-12-01

    Full Text Available James L. Baughman, Jennifer Ratner-Rosenhagen, and James P. Danky, eds, Protest on the Page: Essays on Print and the Culture of Dissent since 1865 (Madison: University of Wisconsin Press, 2015. xv + 259 pp. ISBN 978-0-299-30284-9.

  9. Does SOFA predict outcomes better than SIRS in Brazilian ICU patients with suspected infection? A retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Regis Goulart Rosa

    2017-11-01

    Full Text Available We compared the discriminatory capacity of the sequential organ failure assessment (SOFA versus the systemic inflammatory response syndrome (SIRS score for predicting ICU mortality, need for and length of mechanical ventilation, ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition and SIRS (SIRS score ≥2 points. From January 2008 to December 2014, 1487 patients were admitted to the ICU due to suspected infection. SOFA ≥2 identified more septic patients than SIRS ≥2 (79.0% [n = 1175] vs. 68.5% [n = 1020], p  7 days (AUROC = 0.65 vs. 0.63, p = 0.004, and length of hospitalization >10 days (AUROC = 0.61 vs. 0.59, p 7 days.

  10. Celiac disease in patients with Williams-Beuren syndrome.

    Science.gov (United States)

    Mıhçı, Ercan; Nur, Banu Güzel; Berker-Karaüzüm, Sibel; Yılmaz, Aygen; Artan, Reha

    2015-01-01

    Celiac disease is an autoimmune, gastrointestinal disorder characterized by intolerance to the dietary grain protein gluten. An increased prevalence of celiac disease has been reported in Down syndrome and Turner syndrome, but there has been only few previous reports with respect to the association of celiac disease in Williams-Beuren syndrome. The aim of this study was to evaluate the frequency of celiac disease in our 24 Williams-Beuren syndrome patients. Gastrointestinal problems and celiac disease symptoms of patients were noted. All patients were analyzed by the titer of tissue transglutaminases IgA and IgG. HLA genotyping and intestinal biopsy was performed to the patients with positive serology. We also performed gluten free diet in the presence of compatible symptoms, serology, HLA genotyping and intestinal biopsy. In our study, two patients had positive tTG antibodies, but only one had positive biopsy finding for celiac disease. The frequency of celiac disease in patients with Williams-Beuren syndrome was estimated as 1/24 (4.1%). Though the number of participants in this study was limited, the results show that the frequency of celiac disease is higher in Williams-Beuren syndrome compared to the general population. We suggest that a high suspicion and testing for celiac disease should be recommended at certain intervals in all cases with Williams-Beuren syndrome to detect the cause of growth retardation and gastrointestinal problems.

  11. Williams Syndrome and 15q Duplication: Coincidence versus Association.

    Science.gov (United States)

    Khokhar, Aditi; Agarwal, Swashti; Perez-Colon, Sheila

    2017-01-01

    Williams syndrome is a multisystem disorder caused by contiguous gene deletion in 7q11.23, commonly associated with distinctive facial features, supravalvular aortic stenosis, short stature, idiopathic hypercalcemia, developmental delay, joint laxity, and a friendly personality. The clinical features of 15q11q13 duplication syndrome include autism, mental retardation, ataxia, seizures, developmental delay, and behavioral problems. We report a rare case of a girl with genetically confirmed Williams syndrome and coexisting 15q duplication syndrome. The patient underwent treatment for central precocious puberty and later presented with primary amenorrhea. The karyotype revealed 47,XX,+mar. FISH analysis for the marker chromosome showed partial trisomy/tetrasomy for proximal chromosome 15q (15p13q13). FISH using an ELN -specific probe demonstrated a deletion in the Williams syndrome critical region in 7q11.23. To our knowledge, a coexistence of Williams syndrome and 15q duplication syndrome has not been reported in the literature. Our patient had early pubertal development, which has been described in some patients with Williams syndrome. However, years later after discontinuing gonadotropin-releasing hormone analogue treatment, she developed primary amenorrhea.

  12. "Restructuring" Stirs Outcry at James Madison.

    Science.gov (United States)

    Magner, Denise K.

    1995-01-01

    An administration plan to discontinue the physics major at James Madison University (Virginia) has raised concerns about the president's leadership and management style, and the role of faculty in institutional decision making. Faculty were notified of the plan only after student leaders were told. (MSE)

  13. PALEODRAINAGES OF THE EASTERN SAHARA - THE RADAR RIVERS REVISITED (SIR - A/B IMPLICATIONS FOR A MID - TERTIARY TRANS - AFRICAN DRAINAGE SYSTEM).

    Science.gov (United States)

    McCauley, John F.; Breed, Carlos S.; Schaber, Gerald G.; McHugh, William P.; Issawi, Bahay; Haynes, C. Vance; Grolier, Maurice J.; El Kilani, Ali

    1986-01-01

    A complex history of Cenozoic fluvial activity in the presently hyperarid eastern Sahara is inferred from Shuttle Imaging Radar (SIR) data and postflight field investigations in southwest Egypt and northwest Sudan. SIR images were coregistered with Landsat and existing maps as a guide to exploration of the buried paleodrainages (radar rivers) first discovered by SIR-A. Field observations explain the radar responses of three types of radar rivers: RR-1, RR-2, and RR-3. A generalized model of the radar rivers, based on field studies and regional geologic relations, shows apparent changes in river regimen since the large valleys were established during the late Paleogene-early Neogene eras. SIR-based mapping of these paleodrainages, although incomplete, reveals missing links in an area once thought to be devoid of master streams.

  14. Colour discrimination and categorisation in Williams syndrome

    OpenAIRE

    Farran, E. K.; Cranwell, M. B.; Alvarez, J.; Franklin, A.

    2013-01-01

    Individuals with Williams syndrome (WS) present with impaired functioning of the dorsal visual stream relative to the ventral visual stream. As such, little attention has been given to ventral stream functions in WS. We investigated colour processing, a predominantly ventral stream function, for the first time in nineteen individuals with Williams syndrome. Colour discrimination was assessed using the Farnsworth-Munsell 100 hue test. Colour categorisation was assessed using a match-to-sample ...

  15. 76 FR 44893 - Prince William Sound Resource Advisory Committee

    Science.gov (United States)

    2011-07-27

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource Advisory... District, 145 Forest Station Road, Girdwood, AK; Prince Willam Sound Community College, 303 Lowe Street...

  16. 33 CFR 165.1704 - Prince William Sound, Alaska-regulated navigation area.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Prince William Sound, Alaska... District § 165.1704 Prince William Sound, Alaska-regulated navigation area. (a) The following is a... Hinchinbrook Light to Schooner Rock Light, comprising that portion of Prince William Sound between 146°30′ W...

  17. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    Energy Technology Data Exchange (ETDEWEB)

    Samat, N. A.; Ma' arof, S. H. Mohd Imam [Department of Mathematics, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjung Malim, Perak (Malaysia)

    2014-12-04

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

  18. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    International Nuclear Information System (INIS)

    Samat, N. A.; Ma'arof, S. H. Mohd Imam

    2014-01-01

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases

  19. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    Science.gov (United States)

    Samat, N. A.; Ma'arof, S. H. Mohd Imam

    2014-12-01

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

  20. Looking at the vintage of 1949

    Science.gov (United States)

    Fifty years ago, as 1949 began, AGU dues had been raised from $5 to $7 per year. James Bernard Macelwane had just received the William Bowie Medal. Walter H. Bucher was about to become president, and H. U-.Sverdrup was vice-president.The Union's 4,500 members could choose among eight sections: Geodesy, Seismology, Meteorology, Terrestrial Magnetism and Electricity, Oceanography, Volcanology Hydrology, and Tectonophysics. Of the approximately 200 new members that joined AGU in 1949, 34 are celebrating 50 years of membership this year.The individuals listed below join the distinguished ranks of the other 50-year members. Their continuing commitment to AGU is deeply appreciated. Stephen E. Blewett, William E. Bonini, William M. Cameron, Robert A. Clark, John C. Cook, Joseph S. Cragwall, Jr., Richard C. Culler, Martin M. Fogel, Joseph B. Franzini, Thomas A. Gleeson, O. Milton Hackett, Arthur FHasbrook, James W. Hood, Shragga Irmay William W. Kellogg, Elizabeth R. King, Howard Klein, Finley B. Laverty Heinz H. Lettau, Kurt E. Lowe, Arthur R. Miller, Joseph W Mixsell, Carlo Morelli, Jack E. Oliver, B. H. Olsson, George L. Pickard, John L. Rosenfeld, Thorndike Saville, Jr., John W. Siegmund, James E. Slosson, John Summersett, Harold A. Thomas, Jr., Charles M. Weiss, and Glenn C. Werth.

  1. The hunters of humanity: creatures of horror in M. R. James's ghost stories

    OpenAIRE

    Oryshchuk, Nataliya

    2017-01-01

    In his ghost stories, M.R. James disclosed the most irrational and fearful aspects of archaic demonology still haunting the modern world. He turns humans into prey species, hunted and haunted by repulsive insect- and spider-like demons. This paper offers a closer look at the creatures of horror and the recurrent theme of the hunt in James's ghost stories, viewing them in the context of Victorian evolutionary theories as well as traditional medieval beliefs. James's protagonists, unimaginative...

  2. Florence Jessie Mac Williams

    Indian Academy of Sciences (India)

    CPMGIKAlBGE-340/2003-05. Resonance - January 2005. Licenced to post WPP No.6 RT Nagar Postoffice. Florence Jessie Mac Williams. (1917 - 1990). Registered with Registrar of Newspapers in India vide Regn. No. 66273/96. ISSN 0971-8044. Price per copy: Rs 40.

  3. On the Shoulders of Sir Isaac Newton and Arthur Storer

    Science.gov (United States)

    Martin, Helen E.; Evans-Gondo, Bonita

    2013-01-01

    Helen E. Martin, the author of this article, is a retired National Board Certified Teacher who has been researching Sir Isaac Newton's unpublished manuscripts for over three decades. While researching the work of Newton, a teacher she was mentoring asked for some hands-on activities to study planetary motion. The description of the activity…

  4. Mailability v. the Crusader: Williams v. O'Brien.

    Science.gov (United States)

    Simmons, Charles E.

    The issues of prior restraint and press censorship are examined in this paper, which focuses on the 1970 Williams v. O'Brien court case. The paper discusses the litigation, in which Robert F. Williams, as an American citizen living in Peking, China, sued the United States Postmaster General over the banning of the May 1967 issue of "The…

  5. [Sir Harold Ridley--the creator of modern cataract surgery].

    Science.gov (United States)

    Obuchowska, Iwona; Mariak, Zofia

    2005-01-01

    In February 2000, the worldwide ophthalmology community celebrated the 50th anniversary of one of the twentieth century's most important innovations in eye care--the implantation of the first intraocular lens after cataract extraction by Sir Harold Ridley. It was the initiation of a golden age for the development of ophthalmology, especially cataract surgery. In our paper we would like to remember this outstanding English ophthalmologist and his great invention.

  6. Milline on hea maksusüsteem? Mirrlees Review vastab / Risto Kaarna

    Index Scriptorium Estoniae

    Kaarna, Risto, 1985-

    2010-01-01

    Ülevaade maailma tunnustatud maksuteoreetikute poolt koostatud ülevaatest "Tax by design" (Mirrlees Review). Ülevaade pakub välja üldise hea maksusüsteemi. Uurimuse juhiks on Nobeli preemia laureaat Sir James Mirrlees

  7. Sir Peter Medawar: science, creativity and the popularization of Karl Popper

    Science.gov (United States)

    Calver, Neil

    2013-01-01

    Sir Peter Medawar was respected by scientists and literati alike. It was perhaps not surprising, then, that he would choose to involve himself in the ‘two cultures’ debate of 1959 and beyond. The focus of his intervention was the philosophy of Sir Karl Popper. However, Medawar's Popper was not the guru of falsification familiar from philosophy textbooks. Medawar's distinctive interpretation of Popper treated him instead as the source of insights into the role of creativity and imagination in scientific inquiry. This paper traces the context for Medawar's adoption of Popperian philosophy, together with its application before the debate. It then examines, within the context of the debate itself, the way in which Medawar attempted to reconcile scientific inquiry with literary practice. Medawar became increasingly convinced that not only was induction epistemologically unsound, but it was also damaging to the public role of the scientist. His construction of Popperianism would, he envisaged, provide a worthy alternative for scientists’ self-image.

  8. James Bay Mercury Committee report of activities. Rapport d'activites du Comite de la Baie James sur le mercure

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    The James Bay Mercury Committee has the mandate to oversee the implementation of the research, monitoring, and remediation programs related to the mercury pollution problem associated with hydroelectric developments in the James Bay region of Quebec. A summary of activities for 1990-91 is presented. Monitoring programs conducted during the year included studies of fish in the western part of the LaGrande complex, in which a decrease in Hg levels first noted in 1990 persisted; and a hair sampling and analysis program conducted on high-risk groups in the James Bay Cree population, which noted a continuing downward trend in Hg levels although this trend was not statistically significant. Research programs included a study of the influence of environmental factors on the release of Hg from vegetation and soil flooded by hydroelectric reservoirs. Mercury research in 1990 allowed confirmation of the fact that a higher Hg uptake in certain fish downstream from the LaGrande 2 station was related to a change in their feeding habits. Other studies were conducted on the effects of methylmercury exposure on health, sociocultural and economic aspects, and mitigative measures. Total expenditures for the year were just over $2 million. 8 refs., 3 figs., 2 tabs.

  9. 75 FR 49994 - James Stephen Ferguson, D.M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 09-64] James Stephen Ferguson, D.M.D.; Revocation of Registration On July 24, 2009, the Deputy Assistant Administrator, Office of Diversion Control, Drug Enforcement Administration (DEA), issued an Order to Show Cause to James Stephen...

  10. ACUTE AND CHRONIC TOXICITY OF BREVETOXIN TO OYSTERS AND GRASS SHRIMP

    Science.gov (United States)

    Walker, Calvin C., James T. Winstead, Steven S. Foss, Janis C. Kurtz, James Watts, Jeanne E. Scott and William S. Fisher. In press. Acute and Chronic Toxicity of Brevetoxin to Oysters and Grass Shrimp (Abstract). To be presented at the SETAC Fourth World Congress, 14-18 November ...

  11. David Owen WILLIAMS

    CERN Multimedia

    2006-01-01

    Lidy Williams-Oonk and her children Mark & Marietta, being unable to thank everybody individually, would like to express their sincere thanks to friends and colleagues at CERN and abroad for their great help and support, their messages and flowers, as well as their donations to the Ligue Genevoise contre le Cancer, on the death of their beloved husband and father.

  12. Kunst, kunstiajalugu ja visuaalkultuur / James Elkins ; intervjueerinud Maarin Mürk

    Index Scriptorium Estoniae

    Elkins, James, 1955-

    2010-01-01

    Kultuuriteaduste ja kunstide doktorikool korraldas 20.-22. sept. 2010 Eesti Kunstiakadeemia kunstikultuuri teaduskonnas ameerika kunstiteadlase James Elkensi seminari "Kunst, kunstiajalugu ja visuaalkultuuri uuringud. Uurimise ja kirjastamise probleeme ja kontseptsioone tänapäeval". James Elkensiga kunstiteadusest, sellest, kuidas visuaalkultuuri uurimine paneb küsimärgi alla senise kunstiajaloo ning kuidas on võimalik kirjutada ka Euroopa traditsioonist väljapoole jäävat kunstiajalugu, siinsest kunstiajaloo uurimisest ja kirjutamisest

  13. 77 FR 19301 - Prince William Sound Regional Citizens' Advisory Council Charter Renewal

    Science.gov (United States)

    2012-03-30

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2012-0099] Prince William Sound Regional... Prince William Sound Regional Citizens' Advisory Council (PWSRCAC) as an alternative voluntary advisory group for Prince William Sound, Alaska. This certification allows the PWSRCAC to monitor the activities...

  14. Interaction with William Carnall

    International Nuclear Information System (INIS)

    Judd, Brian R.

    2005-01-01

    A personal account is given of interaction with William T. Carnall during the period 1977-1988, when I made regular visits to the Argonne National Laboratory to discuss the theoretical background to the spectroscopic work he was carrying out on the lanthanides and actinides

  15. Global and local music perception in children with Williams syndrome.

    Science.gov (United States)

    Deruelle, Christine; Schön, Daniele; Rondan, Cécilie; Mancini, Josette

    2005-04-25

    Musical processing can be decomposed into the appreciation of global and local elements. This global/local dissociation was investigated with the processing of contour-violated and interval-violated melodies. Performance of a group of 16 children with Williams syndrome and a group of 16 control children were compared in a same-different task. Control participants were more accurate in detecting differences in the contour-violated than in the interval-violated condition while Williams syndrome individuals performed equally well in both conditions. This finding suggests that global precedence may occur at an early perceptual stage in normally developing children. In contrast, no such global precedence is observed in the Williams syndrome population. These data are discussed in the context of atypical cognitive profiles of individuals with Williams syndrome.

  16. A Possible Source For Sir Thomas More’s ‘Mountainish Inhumanity’

    NARCIS (Netherlands)

    Steenbergh, Kristine

    2017-01-01

    Shakespeare’s authorship of a scene in Sir Thomas More has been established as highly probable on the basis of an analysis of the handwriting, vocabulary, and collocations stylistics. His addition to the play was long believed to have been written soon after publication of the original play, in

  17. Sir Victor Horsley (1857-1916): pioneer of neurological surgery.

    Science.gov (United States)

    Tan, Tze-Ching; Black, Peter McL

    2002-03-01

    Immortalized in surgical history for the introduction of "antiseptic wax," Sir Victor Horsley played a pivotal role in shaping the face of standard neurosurgical practice. His contributions include the first laminectomy for spinal neoplasm, the first carotid ligation for cerebral aneurysm, the curved skin flap, the transcranial approach to the pituitary gland, intradural division of the trigeminal nerve root for trigeminal neuralgia, and surface marking of the cerebral cortex. A tireless scientist, he was a significant player in discovering the cure for myxedema, the eradication of rabies from England, and the invention of the Horsley-Clarke stereotactic frame. As a pathologist, Horsley performed research on bacteria and edema and founded the Journal of Pathology. Horsley's kindness, humility, and generous spirit endeared him to patients, colleagues, and students. Born to privilege, he was nonetheless dedicated to improving the lot of the common man and directed his efforts toward the suffrage of women, medical reform, and free health care for the working class. Knighted in 1902 for his many contributions to medicine, Sir Victor met an untimely death during World War I from heat stroke at the age of 59. An iconoclast of keen intellect, unlimited energy, and consummate skill, his life and work justify his epitaph as a "pioneer of neurological surgery."

  18. 76 FR 76980 - Notice of Listing of Members of the Food and Drug Administration's Senior Executive Service...

    Science.gov (United States)

    2011-12-09

    ...'Tonya Davis Sheryl Lard-Whiteford David Elder Murray Lumpkin Denise Esposito William Maisel Tracy Forfa... Steven Solomon Daniel McChesney Stephen Spielberg William McConagha Roberta Wagner Patrick McGarey David... Murphy Donald Zink Melinda Plaisier Lynne Rice Mark Roh James Sigg Steven Silverman Howard Sklamberg...

  19. Intracranial arteries in individuals with the elastin gene hemideletion of Williams syndrome.

    Science.gov (United States)

    Wint, D P; Butman, J A; Masdeu, J C; Meyer-Lindenberg, A; Mervis, C B; Sarpal, D; Morris, C A; Berman, K F

    2014-01-01

    Williams syndrome, a rare genetic disorder with a striking neurobehavioral profile characterized by extreme sociability and impaired visuospatial construction abilities, is caused by a hemideletion that includes the elastin gene, resulting in frequent supravavular aortic stenosis and other stenotic arterial lesions. Strokes have been reported in Williams syndrome. Although the extracranial carotid artery has been studied in a sample of patients with Williams syndrome, proximal intracranial arteries have not. Using MRA, we studied the intracranial vessels in 27 participants: 14 patients with Williams syndrome (age range, 18-44 years; mean age, 27.3 ± 9.1; 43% women) and 13 healthy control participants with similar age and sex distribution (age range, 22-52 years; mean age, 33.4 ± 7.6; 46% women). All participants with Williams syndrome had hemideletions of the elastin gene. Blinded to group allocation or to any other clinical data, a neuroradiologist determined the presence of intracranial vascular changes in the 2 groups. The Williams syndrome group and the healthy control group had similar patency of the proximal intracranial arteries, including the internal carotid and vertebral arteries; basilar artery; and stem and proximal branches of the anterior cerebral artery, MCA, and posterior cerebral arteries. The postcommunicating segment of the anterior cerebral artery was longer in the Williams syndrome group. Despite the elastin haploinsufficiency, the proximal intracranial arteries in Williams syndrome preserve normal patency.

  20. Sir John and Lady Rita Cornforth: a distinguished chemical partnership.

    Science.gov (United States)

    Purchase, Rupert; Hanson, James R

    2015-01-01

    This review describes the life of Sir John Cornforth AC CBE FRS, who was awarded the Nobel Prize for Chemistry in 1975. It covers his early life in Australia, his work in Oxford, the National Institute for Medical Research, the Milstead Laboratory of Chemical Enzymology and the University of Sussex, together with the contributions made by his wife, Lady Rita Cornforth.

  1. Stability and bifurcation analysis in a delayed SIR model

    International Nuclear Information System (INIS)

    Jiang Zhichao; Wei Junjie

    2008-01-01

    In this paper, a time-delayed SIR model with a nonlinear incidence rate is considered. The existence of Hopf bifurcations at the endemic equilibrium is established by analyzing the distribution of the characteristic values. A explicit algorithm for determining the direction of the Hopf bifurcation and the stability of the bifurcating periodic solutions are derived by using the normal form and the center manifold theory. Numerical simulations to support the analytical conclusions are carried out

  2. James Madison and "The Federalist Papers."

    Science.gov (United States)

    Patrick, John J.; And Others

    A collection of resources for high school history and government teachers and their students, this volume treats core ideas on constitutional government in the United States. James Madison's ideas as found in "The Federalist Papers" are examined in conjunction with their counterpoints in essays of the Anti-Federalists. This volume…

  3. James Bernard Russell: Scholar, collaborator, mentor

    Science.gov (United States)

    At the time of his untimely death in 2009, ARS scientist Dr. James B. Russell had established himself as the premier rumen microbiologist of his generation. Dr. Russell’s many contributions to the field, including much of the early work on the Cornell Net Carbohydrate System model, were the product ...

  4. The use of multifrequency and polarimetric SIR-C/X-SAR data in geologic studies of Bir Safsaf, Egypt

    Science.gov (United States)

    Schaber, G.G.; McCauley, J.F.; Breed, C.S.

    1997-01-01

    Bir Safsaf, within the hyperarid 'core' of the Sahara in the Western Desert of Egypt, was recognized following the SIR-A and SIR-B missions in the 1980s as one of the key localities in northeast Africa, where penetration of dry sand by radar signals delineates previously unknown, sand-buried paleodrainage valleys ('radar-rivers') of middle Tertiary to Quaternary age. The Bir Safsaf area was targeted as a focal point for further research in sand penetration and geologic mapping using the multifrequency and polarimetric SIR-C/X-SAR sensors. Analysis of the SIR-C/X-SAR data from Bir Safsaf provides important new information on the roles of multiple SAR frequency and polarimetry in portraying specific types of geologic units, materials, and structures mostly hidden from view on the ground and on Landsat TM images by a relatively thin, but extensive blanket of blow sand. Basement rock units (granitoids and gneisses) and the fractures associated with them at Bir Safsaf are shown here for the first time to be clearly delineated using C- and L-band SAR images. The detectability of most geologic features is dependent primarily on radar frequency, as shown for wind erosion patterns in bedrock at X-band (3 cm wavelength), and for geologic units and sand and clay-filled fractures in weathered crystal-line basement rocks at C-band (6 cm) and L-band (24 cm). By contrast, Quaternary paleodrainage channels are detectable at all three radar frequencies owing, among other things, to an usually thin cover of blow sand. The SIR-C/X-SAR data investigated to date enable us to make specific recommendations about the utility of certain radar sensor configurations for geologic and paleoenvironmental reconnaissance in desert regions.Analysis of the shuttle imaging radar-C/X-synthetic aperture radar (SIR-C/X-SAR) data from Bir Safsaf provides important new information on the roles of multiple SAR frequency and polarimetry in portraying specific types of geologic units, materials, and

  5. James Madison and a Shift in Precipitation Seasonality

    Science.gov (United States)

    Druckenbrod, D. L.; Mann, M. E.; Stahle, D. W.; Cleaveland, M. K.; Therrell, M. D.; Shugart, H. H.

    2001-12-01

    An eighteen-year meteorological diary and tree ring data from James Madison's Montpelier plantation provide a consistent reconstruction of early summer and prior fall rainfall for the 18th Century Virginia piedmont. The Madison meteorological diary suggests a seasonal shift in monthly rainfall towards an earlier wet season relative to 20th Century norms. Furthermore, dendroclimatic reconstructions of early summer and prior fall rainfall reflect this shift in the seasonality of summer rainfall. The most pronounced early summer drought during the Madison diary period is presented as a case study. This 1792 drought occurs during one of the strongest El Niño events on record and is highlighted in the correspondence of James Madison.

  6. [Association between Williams syndrome and adrenal insufficiency].

    Science.gov (United States)

    Rchachi, Meryem; Larwanou, Maazou Mahamane; El Ouahabi, Hanan; Ajdi, Farida

    2017-01-01

    Williams syndrome is a developmental disorder including dysmorphia, cardiovascular malformations and a specific neuropsychological profile together with other associated disorders. We report the case of a 17-year old girl, born of a non-inbred marriage, with Williams syndrome discovered during an assessment of degree of failure to thrive. Its association with primary adrenal insufficiency makes it unique. Diagnosis is confirmed by cytogenetic and molecular analysis. Its management consists of the implementation of treatment for adrenal insufficiency associated with a clinico-biological monitoring.

  7. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

    DEFF Research Database (Denmark)

    Lombard, David B; Alt, Frederick W; Cheng, Hwei-Ling

    2007-01-01

    Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here, we investigate the localization and function of SIRT3 in vivo. We show that endogenous mouse SIRT3 is a solubl...

  8. The Learning Way: Meta-Cognitive Aspects of Experiential Learning

    Science.gov (United States)

    Kolb, Alice Y.; Kolb, David A.

    2009-01-01

    Contemporary research on meta-cognition has reintroduced conscious experience into psychological research on learning and stimulated a fresh look at classical experiential learning scholars who gave experience a central role in the learning process--William James, John Dewey, Kurt Lewin, Carl Rogers, and Paulo Freire. In particular James's…

  9. White matter integrity deficits in prefrontal-amygdala pathways in Williams syndrome.

    Science.gov (United States)

    Avery, Suzanne N; Thornton-Wells, Tricia A; Anderson, Adam W; Blackford, Jennifer Urbano

    2012-01-16

    Williams syndrome is a neurodevelopmental disorder associated with significant non-social fears. Consistent with this elevated non-social fear, individuals with Williams syndrome have an abnormally elevated amygdala response when viewing threatening non-social stimuli. In typically-developing individuals, amygdala activity is inhibited through dense, reciprocal white matter connections with the prefrontal cortex. Neuroimaging studies suggest a functional uncoupling of normal prefrontal-amygdala inhibition in individuals with Williams syndrome, which might underlie both the extreme amygdala activity and non-social fears. This functional uncoupling might be caused by structural deficits in underlying white matter pathways; however, prefrontal-amygdala white matter deficits have yet to be explored in Williams syndrome. We used diffusion tensor imaging to investigate prefrontal-amygdala white matter integrity differences in individuals with Williams syndrome and typically-developing controls with high levels of non-social fear. White matter pathways between the amygdala and several prefrontal regions were isolated using probabilistic tractography. Within each pathway, we tested for between-group differences in three measures of white matter integrity: fractional anisotropy (FA), radial diffusivity (RD), and parallel diffusivity (λ(1)). Individuals with Williams syndrome had lower FA, compared to controls, in several of the prefrontal-amygdala pathways investigated, indicating a reduction in white matter integrity. Lower FA in Williams syndrome was explained by significantly higher RD, with no differences in λ(1), suggestive of lower fiber density or axon myelination in prefrontal-amygdala pathways. These results suggest that deficits in the structural integrity of prefrontal-amygdala white matter pathways might underlie the increased amygdala activity and extreme non-social fears observed in Williams syndrome. Copyright © 2011 Elsevier Inc. All rights reserved.

  10. Musicalidade e transmissao da voz: James, John e Lucia Joyce // Musicality and transmission of the voice: James, John and Lucia Joyce

    Directory of Open Access Journals (Sweden)

    Renata Mattos

    2012-06-01

    Full Text Available Este artigo tem como objetivo trabalhar a temática da voz, da música e do traço em James Joyce, seu pai John e sua filha Lucia com o intuito de pensar as diferentes saídas possíveis face à questão do sintoma da carência paterna, seja pela elevação ao sinthoma pela escrita de uma obra literária no caso de Joyce, seja pela tentativa de manejo da voz através da dança, no caso de Lucia. Propomos tomar a escrita de James Joyce naquilo que ela nos oferece para pensar a relação entre uma escrita possível da voz e a invocação ao Pai, detendo-nos na transmissão da voz efetuada nestas três gerações da família Joyce, no que cada um deles pôde, de maneiras singulares, criar face ao real. // The aim of this paper is to work the thematic of the voice, the music and the trait in James Joyce, his father John and his daughter Lucia in order to think about the question of the elevation of the symptom of the lack of the father through the writing of James Joyce in his literary work as well as though the relation of Lucia with the dance. Our proposal is to reflect about the writing of Joyce to think about the relation between a possible writing of the voice and the invocation to the Father, as well as the transmission of the voice made in these three generations of the Joyce family in what each one of them could, in different ways, create guided by the real.

  11. Kuula. Kellele ei meeldiks James Blunt? / Mart Juur

    Index Scriptorium Estoniae

    Juur, Mart, 1964-

    2007-01-01

    Heliplaatidest: James Blunt "Back To Bedlam", Enrique Iglesias "Insomniac", Prince "Planet Earth", Garbage "Absolut Garbage", Justice "Cross", Interpol "Our Love To Admire", Rufus Wainwright "Release The Stars"

  12. Sir Rudolf Peierls Selected private and scientific correspondence

    CERN Document Server

    Lee, Sabine

    2007-01-01

    This edition of the private and scientific correspondence of Sir Rudolf Peierls gives a unique insight into the life and work of one of the greatest theoretical physicists of the 20th century. Rudolf Peierls' scientific work contributed to the early developments in quantum mechanics, and he is well known and much appreciated for his contributions to various disciplines, including solid state physics, nuclear physics, and particle physics. As an enthusiastic and devoted teacher, he passed on his knowledge and understanding and inspired the work of collaborators and students alike. As an effecti

  13. Application of Homotopy Perturbation and Variational Iteration Methods to SIR Epidemic Model

    DEFF Research Database (Denmark)

    Ghotbi, Abdoul R.; Barari, Amin; Omidvar, M.

    2011-01-01

    effective strategy against childhood diseases, the development of the framework that would predict the optimal vaccine coverage level needed to prevent the spread of diseases is crucial. The SIR model is a standard compartmental model that has been used to describe many epidemiological diseases...

  14. Discovering Structure in Auditory Input: Evidence from Williams Syndrome

    Science.gov (United States)

    Elsabbagh, Mayada; Cohen, Henri; Karmiloff-Smith, Annette

    2010-01-01

    We examined auditory perception in Williams syndrome by investigating strategies used in organizing sound patterns into coherent units. In Experiment 1, we investigated the streaming of sound sequences into perceptual units, on the basis of pitch cues, in a group of children and adults with Williams syndrome compared to typical controls. We showed…

  15. James Madison and the Constitutional Convention.

    Science.gov (United States)

    Scanlon, Thomas M.

    1987-01-01

    Part 1 of this three-part article traces James Madison's life and focuses primarily on those events that prepared him for leadership in the U.S. Constitutional Convention of 1787. It describes his early love of learning, education, and public service efforts. Part 2 chronicles Madison's devotion to study and preparation prior to the Constitutional…

  16. Dental management of patient with Williams Syndrome - A case report.

    Science.gov (United States)

    Wong, Daniel; Ramachandra, Srinivas Sulugodu; Singh, Ashish Kumar

    2015-01-01

    Williams syndrome is a multisystemic rare genetic disorder caused by deletion of 26-28 genes in the long arm of chromosome 7. It is characterized by developmental and physical abnormalities including congenital cardiovascular abnormalities, mental retardation, neurological features, growth deficiency, genitourinary manifestations, gastrointestinal problems, musculoskeletal problems, unique behavioral characteristics, and dental problems. Dental abnormalities include malocclusion, hypodontia, malformed teeth, taurodontism, pulp stones, increased space between teeth, enamel hypoplasia, and high prevalence of dental caries. Authors report a 17-year-old female patient with underlying Williams syndrome. Oral features and problems seen in the patient are listed. Malocclusion and screwdriver shaped teeth were noticed. Generalized widening of the periodontal ligament space with vital teeth was seen. This finding has not been reported in cases of Williams syndrome earlier. Precautions taken during dental treatment in patients with Williams syndrome are also discussed.

  17. Sir Victor Horsley: pioneer craniopharyngioma surgeon.

    Science.gov (United States)

    Pascual, José M; Prieto, Ruth; Mazzarello, Paolo

    2015-07-01

    Sir Victor Horsley (1857-1916) is considered to be the pioneer of pituitary surgery. He is known to have performed the first surgical operation on the pituitary gland in 1889, and in 1906 he stated that he had operated on 10 patients with pituitary tumors. He did not publish the details of these procedures nor did he provide evidence of the pathology of the pituitary lesions operated on. Four of the patients underwent surgery at the National Hospital for Neurology and Neurosurgery (Queen Square, London), and the records of those cases were recently retrieved and analyzed by members of the hospital staff. The remaining cases corresponded to private operations whose records were presumably kept in Horsley's personal notebooks, most of which have been lost. In this paper, the authors have investigated the only scientific monograph providing a complete account of the pituitary surgeries that Horsley performed in his private practice, La Patologia Chirurgica dell'Ipofisi (Surgical Pathology of the Hypophysis), written in 1911 by Giovanni Verga, Italian assistant professor of anatomy at the University of Pavia. They have traced the life and work of this little-known physician who contributed to the preservation of Horsley's legacy in pituitary surgery. Within Verga's pituitary treatise, a full transcription of Horsley's notes is provided for 10 pituitary cases, including the patients' clinical symptoms, surgical techniques employed, intraoperative findings, and the outcome of surgery. The descriptions of the topographical and macroscopic features of two of the lesions correspond unmistakably to the features of craniopharyngiomas, one of the squamous-papillary type and one of the adamantinomatous type. The former lesion was found on necropsy after the patient's sudden death following a temporal osteoplastic craniectomy. Surgical removal of the lesion in the latter case, with the assumed nature of an adamantinomatous craniopharyngioma, was successful. According to the

  18. Sir William Henry Perkin: The Man and his 'Mauve'

    Indian Academy of Sciences (India)

    design was different. Just before he .... leaving the Royal College of Chemistry to take up manufacturing, as it was ... For Perkin, the situation to start an industry to manufacture .... Alizarin, in the early years of its production, had become a.

  19. The Case of James Leininger: An American Case of the Reincarnation Type.

    Science.gov (United States)

    Tucker, Jim B

    2016-01-01

    Numerous cases of young children who report memories of previous lives have been studied over the last 50 years. Though such cases are more easily found in cultures that have a general belief in reincarnation, they occur in the West as well. This article describes the case of James Leininger, an American child who at age two began having intense nightmares of a plane crash. He then described being an American pilot who was killed when his plane was shot down by the Japanese. He gave details that included the name of an American aircraft carrier, the first and last name of a friend who was on the ship with him, and a location and other specifics about the fatal crash. His parents eventually discovered a close correspondence between James׳s statements and the death of a World War II pilot named James Huston. Documentation of James׳s statements that was made before Huston was identified includes a television interview with his parents that never aired but which the author has been able to review. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. King James II in Foreign Historiography: the Main Scientifi c Trends and Approaches .

    Directory of Open Access Journals (Sweden)

    Stankov Kirill

    2016-07-01

    Full Text Available The fate of the tragic figure of the British king James II Stuart is considered in the article. In this paper the author pays speсial attention to the history of investigation of the character and politics of this person by the British historians, as well as by the leading European and American specialists on the Early Modern Time. The estimates of James II are of vast variety in the British historiography but at the same time diff erent authors have some similar features in their attitude. Except the apologists the British historians on the whole criticized this king and explain that the majority of the problems connected with him are based on the religious factor that is not really right. On the other hand there are some differences in this negative approaches among various scientifi c schools of British historiography. The Whigs stated that James II tried to limit the personal rights of the Englishmen which was the main result of the English revolution of the middle of the 17th century. The Tories proved that the king neglected the gentry’s property rights and tried to transform the dualistic monarchy into absolutism. The Positivists thought that James II supported the Catholic Counterreformation and fought against the Enlightenment. The revisionists and postrevisionists tried to revalue the person of James II based on the true scientific foundations. A special view on James II’ policy is produced by Non-British authors: German, French and American historians.

  1. 75 FR 16159 - Prince William Sound Regional Citizens' Advisory Council (PWSRCAC) Charter Renewal

    Science.gov (United States)

    2010-03-31

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2010-0121] Prince William Sound Regional... the Prince William Sound Regional Citizens' Advisory Council (PWSRCAC) as an alternative voluntary advisory group for Prince William Sound, Alaska. This certification allows the PWSRCAC to monitor the...

  2. Kuidas kõrgemale ohvitserile ettekannet teha / James Stavridis

    Index Scriptorium Estoniae

    Stavridis, James, 1955-

    2013-01-01

    Endine NATO Euroopa liitlasvägede ülemjuhataja jagab nõuandeid mõjusa ja konstruktiivse ettekande kirjutamiseks ja selle esitlemiseks. Lisatud foto, kus kujutatud James Stavridise autasustamist president Toomas Hendrik Ilvese poolt

  3. James Brown, Sample Culture and the Permanent Distance of Glory

    Directory of Open Access Journals (Sweden)

    Steve Jones

    2009-12-01

    Full Text Available The James Brown song ‘I’m Real’ (1988 features lyrics regaled from James Brown’s back catalogue, alongside vocal samples extracted from his earlier hits. As one of the most sampled artists of the hip-hop era, James employed sampling in order to reclaim his position as the “Godfather of Soul” and express his disatisfaction at having his work overtly plundered. The central questions I pose here focus on what the choice to sample himself reveals about Brown’s status as a Soul legend, and whether the contemporaneous James could sincerely live up to the mythic status inherent to the message of ‘I’m Real’ given its self-conscious form. This confusion appears to be an extension of Walter Benjamin’s conception of déjà vu as an acoustic effect - ‘the cool tomb of long ago, from the vault of which the present seems to return only as an echo’ (Benjamin cited in Breyley, 2009: 145 - only here the slippage between past and present is quite literal, involving the discordant imbrication of two divergent temporal states. Via a detailed investigation of the song ‘I’m Real‘, I will probe Brown’s playful employment of his own past. His gambit, I will argue, may be read simultaneously as testament to his own glory, and as a signifier that the excesses of egotistic auto-projection were always more distant than they first appeared to be.

  4. A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability.

    Directory of Open Access Journals (Sweden)

    Tânia Reis

    2010-11-01

    Full Text Available Obesity has a strong genetic component, but few of the genes that predispose to obesity are known. Genetic screens in invertebrates have the potential to identify genes and pathways that regulate the levels of stored fat, many of which are likely to be conserved in humans. To facilitate such screens, we have developed a simple buoyancy-based screening method for identifying mutant Drosophila larvae with increased levels of stored fat. Using this approach, we have identified 66 genes that when mutated increase organismal fat levels. Among these was a sirtuin family member, Sir2. Sirtuins regulate the storage and metabolism of carbohydrates and lipids by deacetylating key regulatory proteins. However, since mammalian sirtuins function in many tissues in different ways, it has been difficult to define their role in energy homeostasis accurately under normal feeding conditions. We show that knockdown of Sir2 in the larval fat body results in increased fat levels. Moreover, using genetic mosaics, we demonstrate that Sir2 restricts fat accumulation in individual cells of the fat body in a cell-autonomous manner. Consistent with this function, changes in the expression of metabolic enzymes in Sir2 mutants point to a shift away from catabolism. Surprisingly, although Sir2 is typically upregulated under conditions of starvation, Sir2 mutant larvae survive better than wild type under conditions of amino-acid starvation as long as sugars are provided. Our findings point to a Sir2-mediated pathway that activates a catabolic response to amino-acid starvation irrespective of the sugar content of the diet.

  5. Anderson, Prof. Basil Williams

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1964 Honorary. Anderson, Prof. Basil Williams. Date of birth: 3 July 1901. Date of death: 24 February 1984. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...

  6. Series, Prof. George William

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1984 Honorary. Series, Prof. George William. Date of birth: 22 February 1920. Date of death: 2 January 1995. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...

  7. Kirjad riigikantslerile / Katre Kaju

    Index Scriptorium Estoniae

    Kaju, Katre

    2008-01-01

    Rets. rmt.: Letters from Sir James Spens and Jan Rutgers. Edited by Arne Jönsson. (The Works and Correspondence of Axel Oxenstierna edited by The Royal Swedish Academy in co-operation with The Swedish National Archives, 2:13). Stockholm, 2007.

  8. Wittgenstein: an expressivist approach about emotions = Wittgenstein: uma abordagem expressivista sobre as emoções

    Directory of Open Access Journals (Sweden)

    Carmo, Juliano Santos do

    2014-01-01

    Full Text Available Neste trabalho, tem-se a intenção de mostrar que a abordagem de Wittgenstein sobre os conceitos de sensação e emoção pode lançar luz sobre muitos dilemas filosóficos que permanecem presentes no debate contemporâneo. A minha análise tem como ponto de partida a abordagem de Jesse Prinz sobre as emoções, a qual é fortemente influenciada pela teoria fisiológica de William James. Nesse sentido, procurarei mostrar que Prinz está sujeito as mesmas críticas que Wittgenstein endereçou à teoria de William James. Por fim, eu argumentarei que Wittgenstein, nas Investigações filosóficas, defendeu um tipo peculiar de expressivismo que, apesar de manter profundas diferenças com o expressivismo tradicional, é capaz de figurar como uma posição não-cognitivista. Argumentarei, adicionalmente, que o erro na teoria de William James (e, portanto, também o erro de Prinz é não considerar os múltiplos usos dos termos psicológicos (ou seja, pensar que os termos psicológicos possuem um uso uniforme

  9. 78 FR 70027 - Senior Executive Service; Performance Review Board

    Science.gov (United States)

    2013-11-22

    ..., WILLIAM N. BURROWS, CHARLES W. BUTTRESS, LARRY D. CADIEUX, GENA E. CALBOS, PHILIP T. CALLAHAN, SAMUEL N..., LARRY N. BELL, MELODY C. BESTANI, ROBERT M. BIENIAWSKI, ANDREW J. BIERBOWER, WILLIAM J. BINKLEY, JOHN S..., STAN M. KEARNEY, JAMES H. KELLY, HENRY C. KELLY, JOHN E. KELLY, LARRY C. KENCHINGTON, HENRY S. KENDELL...

  10. May thrombopoietin be a useful marker of sepsis severity assessment in patients with SIRS entering the emergency department?

    Science.gov (United States)

    Segre, Elisabetta; Pigozzi, Luca; Lison, Davide; Pivetta, Emanuele; Bosco, Ornella; Vizio, Barbara; Suppo, Umberto; Turvani, Fabrizio; Morello, Fulvio; Battista, Stefania; Moiraghi, Corrado; Montrucchio, Giuseppe; Lupia, Enrico

    2014-10-01

    Thrombopoietin (TPO), a growth factor primarily involved in regulating thrombopoiesis, has been recently implicated in the pathogenesis of sepsis. TPO levels are, indeed, greatly increased in patients with sepsis compared to control subjects, and correlate with sepsis severity. The aim of this study was to evaluate TPO as predictive biomarker of sepsis and of sepsis severity in patients entering the emergency department (ED) with systemic inflammatory response syndrome (SIRS). This was a prospective observational study. Ours is a sub-study of the 'Need-speed trial', a multi-center observational study involving six Italian centers affiliated to the GREAT Italian Network. TPO was measured by ELISA. We enrolled 13 patients with SIRS (6 with acute pancreatitis, 3 with acute heart failure, 1 with pulmonary embolism, and 3 with allergic reactions), and 40 patients with sepsis, eight of whom had severe sepsis and three septic shock. TPO was significantly higher in patients with sepsis than with SIRS. In addition, TPO was higher in patients with severe sepsis than with sepsis, and in patients with septic shock than with severe sepsis, although these differences did not reach the statistical significance. Our preliminary results suggest that TPO may have the potential to be considered a promising early biomarker for both the diagnosis of sepsis and the assessment of sepsis severity in patients with SIRS entering the ED.

  11. Entrevista a James Curran

    OpenAIRE

    Curran, James; Figueiras, Rita; Ribeiro, Nelson

    2012-01-01

    James Curran é professor catedrático e diretor do Goldsmiths Leverhulme Media Research Centre. A sua investigação centra-se sobretudo na relação entre os media e a democracia, quer através do ângulo da história dos media, quer da economia política dos media, áreas sobre as quais publicou mais de duas dezenas de livros, como Media and Democracy, Power without Responsability (co-autoria de Jean Seaton) e Media and Society. Na sua obra mais recente, Misunderstanding the Internet (co-autoria de N...

  12. Societe d'energie de la Baie James, progress report 1991

    International Nuclear Information System (INIS)

    1992-01-01

    The Societe d'energie de la Baie James is a wholly owned subsidiary of Hydro-Quebec and is responsible for harnessing the hydroelectric resources of the James Bay territory. The Societe executes, manages, and administers the design and construction of hydroelectric development projects in the James Bay territory as well as any other project assigned by Hydro-Quebec. In 1991, the Societe saw its strongest surge of activity since development projects were resumed in 1986. Work at the La Grande -2A, La Grande-1, Laforge-1, and Brisay developments, representing over 4,500 MW of installed capacity, continued in compliance with schedules and cost projections. The first three turbine generator units of La Grande-2A were commissioned and detailed design continued for Laforge-2 and Eastmain-1. At LaGrande-1, the spillway and two embankments were completed; at Brisay,excavation of headrace tunnels and the tailbay of the power station were completed; and in total, over $500 million in contracts and $54 million in purchases were made in 1991. 15 figs., 2 tabs

  13. Little Book, Big Waves: The Epistle of James and Global Stewardship in Bioethics

    Directory of Open Access Journals (Sweden)

    Lora Jean Brake

    2016-03-01

    Full Text Available At first glance the twenty-first century arena of biotechnology and bioethics seems worlds away from the practical concerns of the first century outlook of the New Testament book of James. A closer look, however, reveals that the issues that James addresses have applications to challenges in bioethics. This article will give an overview of James and examine James’ teaching on wealth, poverty, and generosity and its import for the issue of global stewardship in bioethics.  Stewardship concerns both a Christian’s care and management of time, talents, and treasures.  Faithful use of the resources God has given demonstrates the fruitful faith that James writes of in his epistle. The idea of global stewardship, though “stewardship” is grounded in a distinctly Christian ethic, reflects an emerging discussion in bioethics regarding the need to address the inequities present between the money and time spent on biotechnology in some of the world in proportion to the money spent on meeting the basic healthcare needs of the poor of the entire world.  This New Testament epistle gives clear indications of how the Christian is to view wealth and how the Christian is to respond to poverty.  James, though a comparatively small book, sends a crucial message across the years that should greatly impact how Christians view stewardship in terms of global healthcare needs. 

  14. Young James Madison: His Character and Civic Values.

    Science.gov (United States)

    Bennett, William J.

    1987-01-01

    Examines the life of James Madison, Founding Father and "theoretic statesman." Focuses specifically on Madison's education and character, his friendship with Thomas Jefferson, and his civic legacy: a selfless devotion to republican government and union. (JDH)

  15. The use of emotions in narratives in Williams syndrome.

    Science.gov (United States)

    Van Herwegen, Jo; Aznar, Ana; Tenenbaum, Harriet

    2014-01-01

    Although individuals with Williams syndrome are very sociable, they tend to have limited contact and friendships with peers. In typically developing children the use of positive emotions (e.g., happy) has been argued to be related to peer relationships and popularity. The current study investigated the use and development of emotion words in Williams syndrome using cross-sectional developmental trajectories and examined children's use of different types of emotion words. Nineteen children with Williams syndrome (WS) and 20 typically developing (TD) children matched for chronological age told a story from a wordless picture book. Participants with WS produced a similar number of emotion words compared to the control group and the use of emotion words did not change when plotted against chronological age or vocabulary abilities in either group. However, participants with WS produced more emotion words about sadness. Links between emotion production and friendships as well as future studies are discussed. After reading this article, readers will be able to: explain the development of positive and negative emotions in Williams syndrome and recognize that emotion production is atypical in this population. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. 33 CFR 167.1701 - In Prince William Sound: Precautionary areas.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false In Prince William Sound: Precautionary areas. 167.1701 Section 167.1701 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1701 In Prince William Sound...

  17. A MacWilliams Identity for Convolutional Codes : The General Case

    NARCIS (Netherlands)

    Gluesing-Luerssen, Heide; Schneider, Gert

    A MacWilliams Identity for convolutional codes will be established. It makes use of the weight adjacency matrices of the code and its dual, based on state space realizations (the controller canonical form) of the codes in question. The MacWilliams Identity applies to various notions of duality

  18. NASA 3D Models: James Webb Space Telescope

    Data.gov (United States)

    National Aeronautics and Space Administration — The James Webb Space Telescope (JWST) will be a large infrared telescope with a 6.5-meter primary mirror. The project is working to a 2018 launch date. The JWST will...

  19. Probed Serial Recall in Williams Syndrome: Lexical Influences on Phonological Short-Term Memory

    Science.gov (United States)

    Brock, Jan; McCormack, Teresa; Boucher, Jill

    2005-01-01

    Williams syndrome is a genetic disorder that, it has been claimed, results in an unusual pattern of linguistic strengths and weaknesses. The current study investigated the hypothesis that there is a reduced influence of lexical knowledge on phonological short-term memory in Williams syndrome. Fourteen children with Williams syndrome and 2…

  20. Agro-transformation and evaluation of resistance to Phytophthora infestansin Solanum tuberosumL. variety Désirée

    Directory of Open Access Journals (Sweden)

    Jeanette Orbegozo

    2014-03-01

    Full Text Available The Oomycete Phytophthora infestans (Mont. de Bary, the causal agent of the disease known as late blight, is primarily responsible for the decreased in production performance and potato crops worldwide. The integration of the complete Rgenes sequences in the potato genome using Agro-transformation appears an alternative to be considered in the fight against this pathogen. The Rpi-blb2 gene (Rgene from the wild species Solanum bulbocastanumDunal shows a broad resistance to isolates ofP. infestans,making it an important candidate for plant breeding studies. This paper reports the integration of the Rpi-blb2gene into potato var. Désirée genome by Agrobacterium tumefaciens- mediated transformation system, the molecular characterization of 29 events transformed and whole plant infection with isolate POX67 of P. infestansfrom Peru. Désirée events [Rpi-blb2] 4 and Désirée [Rpi-blb2] 30, showed a substantial resistance to P. infestansinfection confirming complete transfer of the Rpi-blb2gene from a wild species to a cultivated species by genetic transformation.

  1. 78 FR 28953 - William D. Ford Federal Direct Loan Program

    Science.gov (United States)

    2013-05-16

    .... Ford Federal Direct Loan Program; Interim Final Rule #0;#0;Federal Register / Vol. 78, No. 95... [Docket ID ED-2013-OPE-0066] RIN 1840-AD13 William D. Ford Federal Direct Loan Program AGENCY: Office of... Secretary amends the William D. Ford Federal Direct Loan Program (Direct Loan Program) regulations to...

  2. Pursuing the Panderer: An Analysis of "United States v. Williams"

    Science.gov (United States)

    McGrain, Patrick N.; Moore, Jennifer L.

    2010-01-01

    In May 2008, the Supreme Court addressed whether the government can regulate the ownership and distribution of virtual child pornography. "U.S. v. Williams" marked the first time the Court directly addressed the concept of pandering virtual child pornography. This article examines the Court's decision in "U.S. v. Williams" and…

  3. A Conversation with James Hannan

    OpenAIRE

    Gilliland, Dennis; Ramamoorthi, R. V.

    2010-01-01

    Jim Hannan is a professor who has lived an interesting life and one whose fundamental research in repeated games was not fully appreciated until late in his career. During his service as a meteorologist in the Army in World War II, Jim played poker and made weather forecasts. It is curious that his later research included strategies for repeated play that apply to selecting the best forecaster. ¶ James Hannan was born in Holyoke, Massachusetts on September 14, 1922. He attended St. Jero...

  4. James Peacock, Understanding Paul Auster

    Directory of Open Access Journals (Sweden)

    Chrysavgi Papayianni

    2011-10-01

    Full Text Available Paul Auster’s impressive gamut of work continues to incite fascination and controversy. Indeed, his compelling storytelling style taken together with his mixing of crime fiction and absurdism has made his readers and critics vacillate between praise and condemnation. James Peacock’s Understanding Paul Auster, sheds new light to otherwise obscure aspects of Auster’s novels, films, and other works undermining in this way the negative criticism of the past and thus creating a new appreciation fo...

  5. Prince William Sound, Alaska ESI: INDEX

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) data for Prince William Sound, Alaska. ESI data characterize estuarine environments and wildlife by...

  6. James Madison University Survey of Faculty Activities.

    Science.gov (United States)

    James Madison Univ., Harrisonburg, VA.

    The activities of the faculty at James Madison University during the fall term of the academic year 1978-79 are described. Full-time instructional faculty, part-time faculty involved in resident instruction, administrators and classified employees who taught at least one course, and graduate teaching assistants were surveyed. Information was…

  7. Using novel control groups to dissect the amygdala's role in Williams syndrome.

    Science.gov (United States)

    Thornton-Wells, Tricia A; Avery, Suzanne N; Blackford, Jennifer Urbano

    2011-07-01

    Williams syndrome is a neurodevelopmental disorder with an intriguing behavioral phenotype-hypersociability combined with significant non-social fears. Previous studies have demonstrated abnormalities in amygdala function in individuals with Williams syndrome compared to typically-developing controls. However, it remains unclear whether the findings are related to the atypical neurodevelopment of Williams syndrome, or are also associated with behavioral traits at the extreme end of a normal continuum. We used functional magnetic resonance imaging (fMRI) to compare amygdala blood-oxygenation-level-dependent (BOLD) responses to non-social and social images in individuals with Williams syndrome compared to either individuals with inhibited temperament (high non-social fear) or individuals with uninhibited temperament (high sociability). Individuals with Williams syndrome had larger amygdala BOLD responses when viewing the non-social fear images than the inhibited temperament control group. In contrast, when viewing both fear and neutral social images, individuals with Williams syndrome did not show smaller amygdala BOLD responses relative to the uninhibited temperament control group, but instead had amygdala responses proportionate to their sociability. These results suggest heightened amygdala response to non-social fear images is characteristic of WS, whereas, variability in amygdala response to social fear images is proportionate to, and might be explained by, levels of trait sociability.

  8. The Scientific Papers of James Clerk Maxwell

    Science.gov (United States)

    Clerk Maxwell, James; Niven, W. D.

    2011-01-01

    27. On the viscosity or internal friction of air and other gases; 28. On the dynamical theory of gases; 29. On the theory of the maintenance of electric currents by mechanical work without the use of permanent magnets; 30. On the equilibrium of a spherical envelope; 31. On the best arrangement for producing a pure spectrum on a screen; 32. The construction of stereograms of surfaces; 33. On reciprocal diagrams in space and their relation to Airy's function of stress; 34. On governors; 35. Experiment in magneto-electric induction; 36. On a method of making a direct comparison of electrostatic with electromagnetic force; 37. On the cyclide; 38. On a bow seen on the surface of ice; 39. On reciprocal figures, frames, and diagrams of forces; 40. On the displacement in a case of fluid motion; 41. Address to the mathematical and physical sections of the British Association, 1870; 42. On colour-vision at different points of the retina; 43. On hills and dales; 44. Introductory lecture on experimental physics; 45. On the solution of electrical problems by the transformation of conjugate functions; 46. On the mathematical classification of physical quantities; 47. On colour vision; 48. On the geometrical mean distance of two figures on a plane; 49. On the induction of electric currents in an infinite plane sheet of uniform conductivity; 50. On the condition that, in the transformation of any figure by curvilinear co-ordinates in three dimensions, every angle in the new figure shall be equal to the corresponding angle in the original figure; 51. Reprint of Papers on electrostatics and magnetism. By Sir W. Thomson. (Review); 52. On the proof of the equations of motion of a connected system; 53. On a problem in the calculus of variations in which the solution is discontinuous; 54. On action at a distance; 55. Elements of natural philosophy. By Sir W. Thomson and P. G. Tait. (Review); 56. On the theory of a system of electrified conductors, and other physical theories involving

  9. How acquainting shows verbally

    DEFF Research Database (Denmark)

    Hermann, Jesper

    2004-01-01

    A central tenet of the integrational view of language and communication is an anchoring in the acting and integrating behaviour of the communicants themselves. In this way the integrational approach has a certain phenomenological slant. What happens when this approach is combined with a ¿psycholo...... to some of William James' classical psychological observations. 16...... of linguistic exertion¿ based upon the descriptions of the  stream of thought, and of conception (>acquainting) by William James? Text-examples taken from an internet site for dieters illustrate the combined James'ian & integrational approach in practice. Some of the examples are also specifically related......A central tenet of the integrational view of language and communication is an anchoring in the acting and integrating behaviour of the communicants themselves. In this way the integrational approach has a certain phenomenological slant. What happens when this approach is combined with a ¿psychology...

  10. 76 FR 1187 - Application for Recertification of Prince William Sound Regional Citizens' Advisory Council

    Science.gov (United States)

    2011-01-07

    ... Prince William Sound Regional Citizens' Advisory Council AGENCY: Coast Guard, DHS. ACTION: Notice of... on, the application for recertification submitted by the Prince William Sound Regional Citizen's... advisory group in lieu of a Regional Citizens' Advisory Council for Prince William Sound, Alaska. This...

  11. Dreamers in dialogue: evolution, sex and gender in the utopian visions of William Morris and William Henry Hudson

    Directory of Open Access Journals (Sweden)

    Caterina Novák

    2013-12-01

    Full Text Available The aim of this article is to explore the parallels between two late-nineteenth-century utopias,William Henry Hudsons A Crystal Age (1882 and William Morriss News from Nowhere (1891. Itaims to explore how these two works respond to the transition from a kinetic to a static conception ofutopia that under pressure from evolutionary and feminist discourses took place during the period.Particular focus lies on the way in which this is negotiated through the depiction of evolution, sexuality,and gender roles in the respective novels, and how the depiction of these disruptive elements may workas a means of ensuring the readers active engagement in political, intellectual and emotional terms.

  12. The optimal dynamic immunization under a controlled heterogeneous node-based SIRS model

    Science.gov (United States)

    Yang, Lu-Xing; Draief, Moez; Yang, Xiaofan

    2016-05-01

    Dynamic immunizations, under which the state of the propagation network of electronic viruses can be changed by adjusting the control measures, are regarded as an alternative to static immunizations. This paper addresses the optimal dynamical immunization under the widely accepted SIRS assumption. First, based on a controlled heterogeneous node-based SIRS model, an optimal control problem capturing the optimal dynamical immunization is formulated. Second, the existence of an optimal dynamical immunization scheme is shown, and the corresponding optimality system is derived. Next, some numerical examples are given to show that an optimal immunization strategy can be worked out by numerically solving the optimality system, from which it is found that the network topology has a complex impact on the optimal immunization strategy. Finally, the difference between a payoff and the minimum payoff is estimated in terms of the deviation of the corresponding immunization strategy from the optimal immunization strategy. The proposed optimal immunization scheme is justified, because it can achieve a low level of infections at a low cost.

  13. An SIRS model with a nonlinear incidence rate

    International Nuclear Information System (INIS)

    Jin Yu; Wang, Wendi; Xiao Shiwu

    2007-01-01

    The global dynamics of an SIRS model with a nonlinear incidence rate is investigated. We establish a threshold for a disease to be extinct or endemic, analyze the existence and asymptotic stability of equilibria, and verify the existence of bistable states, i.e., a stable disease free equilibrium and a stable endemic equilibrium or a stable limit cycle. In particular, we find that the model admits stability switches as a parameter changes. We also investigate the backward bifurcation, the Hopf bifurcation and Bogdanov-Takens bifurcation and obtain the Hopf bifurcation criteria and Bogdanov-Takens bifurcation curves, which are important for making strategies for controlling a disease

  14. The poor in the Epistle of James and the Gospel of Thomas

    Directory of Open Access Journals (Sweden)

    Patrick J. Hartin

    1997-12-01

    Full Text Available This study explores similarities in the thought world of the Epistle of James and the Gospel of Thomas. Particular attention is devoted to the role that the 'poor' and 'poverty' play in both documents. For the Epistle of James it is 'the poor in the world that God has chosen to be rich in faith and heirs of the kingdom' (Ja 2:5.  In a similar vein, in the Gospel of Thomas the kingdom is promised to those who have embraced the poverty of a radical life-style: 'Blessed are the poor, for yours is the kingdom of heaven' (GTh 54. This outlook betrays a basic ethos adopted toward the world. In both the Epistle of James and the Gospel of Thomas the relationship to the world ultimately determines one's relationship to the kingdom or to God. For the Epistle of James the very definition of religion demands that one keep 'oneself unstained from  the world' (Ja 1 :27 and that 'friendship with the world' is enmity with God (Ja 4:4. For the Gospel of Thomas the rejection of the world involves a radical ethos that embraces an intinerant life ('Be passersby' [GTh 42J, which includes a rejection of wealth (GTh 63.'If you do not abstain from the world, you will not find the kingdom' (GTh 27. It is argued that the Gospel of Thomas and the Epistle of James reflect traditional sayings that endorse a similar ethos of radical discipleship.

  15. 40 CFR 81.347 - Virginia.

    Science.gov (United States)

    2010-07-01

    ... County X King William County X Lancaster County X Louisa County X Madison County X Mathews County X... Intrastate AQCR: Isle of Wight County X James City County X Southampton County X York County X City of... County X King George County X King William County X Lancaster County X Louisa County X Madison County X...

  16. A case of William's syndrome associated peripheral pulmonary arterial stenosis

    International Nuclear Information System (INIS)

    Jung, Kyung Hwa; Hwang, Mi Soo; Kim, Sun Yong; Chang, Jae Chun; Park, Bok Hwan

    1988-01-01

    William's syndrome, in order to more completely delineate the total spectrum of the disorder, indicates that 'infantile hypercalcemia', 'peculiar facies' and 'supravalvular aortic stenosis.' In has other many vascular anomalies, such as peripheral pulmonary arterial stenosis, coronary arterial stenosis, celiac arterial stenosis, and renal aterial stenosis. Only 32% of the patients have evidence of supravalvular aortic stenosis. And it is very rare disease entity that has been reported rarely in Korea. Recently authors experienced a case that was questioned William's syndrome with peripheral pulmonary arterial stenosis, clinically and preliminary radiologically and this case was confirmed by operation. Here we report a case of William's syndrome with peripheral pulmonary arterial stenosis and reviewed literatures

  17. Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.

    Science.gov (United States)

    Ondracek, Caitlin R; Frappier, Vincent; Ringel, Alison E; Wolberger, Cynthia; Guarente, Leonard

    2017-03-07

    Sirtuin enzymes depend on NAD + to catalyze protein deacetylation. Therefore, the lowering of NAD + during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic screen to identify two mutations in the catalytic domain of yeast Sir2 that allow the enzyme to function in an NAD + -depleted environment. These mutant enzymes give rise to a significant increase of yeast replicative lifespan and increase deacetylation by the Sir2 ortholog, SIRT1, in mammalian cells. Our data suggest that these mutations increase the stability of the conserved catalytic sirtuin domain, thereby increasing the catalytic efficiency of the mutant enzymes. Our approach to identifying sirtuin mutants that permit function in NAD + -limited environments may inform the design of small molecules that can maintain sirtuin activity in aging organisms. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  18. Plasma: the genesis of the word

    OpenAIRE

    Pinheiro, Mario J.

    2007-01-01

    The historical roots of the word plasma are recalled. It is suggested that possibly at the beginning of the researches in low-pressure gas discharges the driving motivation was related to the psychic phenomena investigated by Sir William Crookes.

  19. James Joyce, music and memory

    OpenAIRE

    Brown, Katie

    2007-01-01

    This thesis, James Joyce, Music and Memory, explores the connection between music and Irish cultural memory in Joyce’s works from Chamber Music to the “pure music” of Finnegans Wake. Overall, it shows that Joyce’s ongoing desire to emulate musical forms must be seen in light of Joyce’s wish to come to terms with Irish cultural history, as these are the driving forces that bring about his changes in style. TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please cont...

  20. 77 FR 73510 - Virginia Disaster #VA-00052

    Science.gov (United States)

    2012-12-10

    ...; Madison; Manassas City; Mathews; Middlesex; Nelson; Northampton; Northumberland; Prince William... injury is 133998. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera...

  1. A MacWilliams Identity for Convolutional Codes: The General Case

    OpenAIRE

    Gluesing-Luerssen, Heide; Schneider, Gert

    2008-01-01

    A MacWilliams Identity for convolutional codes will be established. It makes use of the weight adjacency matrices of the code and its dual, based on state space realizations (the controller canonical form) of the codes in question. The MacWilliams Identity applies to various notions of duality appearing in the literature on convolutional coding theory.

  2. Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination

    OpenAIRE

    Miao, Anqi; Zhang, Jian; Zhang, Tongqian; Pradeep, B. G. Sampath Aruna

    2017-01-01

    A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control.

  3. 75 FR 59237 - TRICARE Co-Pay Waiver at Captain James A. Lovell Federal Health Care Center Demonstration Project

    Science.gov (United States)

    2010-09-27

    ... DEPARTMENT OF DEFENSE Office of the Secretary TRICARE Co-Pay Waiver at Captain James A. Lovell.... ACTION: Notice of TRICARE Co-Pay waiver at Captain James A. Lovell Federal Health Care Center... ``TRICARE Co-Pay Waiver at Captain James A. Lovell Federal Health Care (FHCC) Demonstration Project.'' Under...

  4. Bora Bora, Tahaa, and Raiatea, French Polynesia, Landsat and SIR-C Images Compared to SRTM Shaded

    Science.gov (United States)

    2005-01-01

    Bora Bora, Tahaa, and Raiatea (top to bottom) are Polynesian Islands about 220 kilometers (135 miles) west-northwest of Tahiti in the South Pacific. Each of the islands is surrounded by a coral reef and its associated islets ('motus') that enclose a lagoon. Actually, as seen here, Tahaa and Raiatea are close enough together to share a common lagoon and reef. These islands are volcanic in origin and were built up from the sea floor by lava extrusions millions of years ago. None is now active, and all are deeply eroded. This display compares three differing 'views from space' of these islands. On the left, an image from the Landsat 7 satellite shows the islands as they might have appeared to an astronaut in orbit in 1999 (but a little sharper and with atmospheric haze suppressed). In the middle is an image created from data gathered by the third-generation Shuttle Imaging Radar (SIR-C), flown in 1994. On the right is a graphic illustrating elevation data gathered by the Shuttle Radar Topography Mission (SRTM) in 2000. Each of these images shows very different information as compared to the other two. Landsat sees clouds, which are almost always above these islands, blocking the view of the terrain. It also readily sees through shallow water down to the reefs. SIR-C sees the waves and other effects of winds upon the ocean surface. It does not look through water to see the reefs, but it clearly separates land and water. It also provides a bolder (but distorted) view of the islands' topographic patterns. With the ability of radar to see through clouds and provision of its own illumination, the SIR-C view is not limited by clouds nor their shadows. SRTM was designed to provide new information that is missing in the Landsat and SIR-C views. Specifically, SRTM created the world's first near-global, detailed elevation model. Natural topographic shading in Landsat imagery and radar topographic shadowing of SIR-C give some evidence of the shape of the ground but do not

  5. Unheard voices: James Bay II and the women of Kuujjuarapik

    Energy Technology Data Exchange (ETDEWEB)

    Hawkes, S. (Waterloo Univ., ON (Canada))

    The attitudes held by the aboriginal peoples of the James Bay region toward the James Bay II hydroelectric power development are described. These attitudes are communicated primarily through the comments of Innu women. Major concerns with the Great Whale project relate to its impact on country food, mercury contamination, and camps. The entire community of Kuujjuarapik was totally opposed to the Great Whale project. While direct impacts such as mercury contamination or reduced wildlife harvest are the most obvious impacts, indirect impacts relating to cultural damage, increased abuse and alcoholism, and influx of non-native construction workers will also have significant effects, and warrant further study.

  6. Unheard voices: James Bay II and the women of Kuujjuarapik

    International Nuclear Information System (INIS)

    Hawkes, S.

    1991-01-01

    The attitudes held by the aboriginal peoples of the James Bay region toward the James Bay II hydroelectric power development are described. These attitudes are communicated primarily through the comments of Innu women. Major concerns with the Great Whale project relate to its impact on country food, mercury contamination, and camps. The entire community of Kuujjuarapik was totally opposed to the Great Whale project. While direct impacts such as mercury contamination or reduced wildlife harvest are the most obvious impacts, indirect impacts relating to cultural damage, increased abuse and alcoholism, and influx of non-native construction workers will also have significant effects, and warrant further study

  7. Henry James – Modern Theoretician of Narration

    Directory of Open Access Journals (Sweden)

    Alexandra - Denisa IGNA

    2013-01-01

    Full Text Available Henry James, properly named world writer, was one of the first modern novelists, with an exigent writing conscience. The American writer subverted the prejudgement of the omniscient author in favour of the narration which is centred on the characters’ point of view, thus modernising the novel before V. Woolf, Huxley, Thomas Mann, or in our case Camil Petrescu and G. Călinescu. Some bio-bibliographical information familiarises the reader with the life and work of this writer. The larger part of the article is dedicated to a case study of the novel with the metaphorical title: The Figure in the Carpet, where Henry James tries to illustrate in an artistic manner his conception regarding the profundity and ineffability of the literary creation. The conclusion which the author reaches, alternating the familiar plan of the relationship between a married couple with the esthetical plan, is that the relationship between writer and his work represents an act of fully intimacy, just like a ceremony that takes place in the wedding night

  8. Psychotherapy In General Practice

    African Journals Online (AJOL)

    1974-08-03

    Aug 3, 1974 ... According to Sir William OsIer, 'The contractor put in poor materials'. ... affairs, stressful situations at work, tension, lack of scope . for self-realisation or ... endure an emotional impact of a very high intensity, which may even ...

  9. Learning by observation: insights from Williams syndrome.

    Science.gov (United States)

    Foti, Francesca; Menghini, Deny; Mandolesi, Laura; Federico, Francesca; Vicari, Stefano; Petrosini, Laura

    2013-01-01

    Observing another person performing a complex action accelerates the observer's acquisition of the same action and limits the time-consuming process of learning by trial and error. Observational learning makes an interesting and potentially important topic in the developmental domain, especially when disorders are considered. The implications of studies aimed at clarifying whether and how this form of learning is spared by pathology are manifold. We focused on a specific population with learning and intellectual disabilities, the individuals with Williams syndrome. The performance of twenty-eight individuals with Williams syndrome was compared with that of mental age- and gender-matched thirty-two typically developing children on tasks of learning of a visuo-motor sequence by observation or by trial and error. Regardless of the learning modality, acquiring the correct sequence involved three main phases: a detection phase, in which participants discovered the correct sequence and learned how to perform the task; an exercise phase, in which they reproduced the sequence until performance was error-free; an automatization phase, in which by repeating the error-free sequence they became accurate and speedy. Participants with Williams syndrome beneficiated of observational training (in which they observed an actor detecting the visuo-motor sequence) in the detection phase, while they performed worse than typically developing children in the exercise and automatization phases. Thus, by exploiting competencies learned by observation, individuals with Williams syndrome detected the visuo-motor sequence, putting into action the appropriate procedural strategies. Conversely, their impaired performances in the exercise phases appeared linked to impaired spatial working memory, while their deficits in automatization phases to deficits in processes increasing efficiency and speed of the response. Overall, observational experience was advantageous for acquiring competencies

  10. Learning by observation: insights from Williams syndrome.

    Directory of Open Access Journals (Sweden)

    Francesca Foti

    Full Text Available Observing another person performing a complex action accelerates the observer's acquisition of the same action and limits the time-consuming process of learning by trial and error. Observational learning makes an interesting and potentially important topic in the developmental domain, especially when disorders are considered. The implications of studies aimed at clarifying whether and how this form of learning is spared by pathology are manifold. We focused on a specific population with learning and intellectual disabilities, the individuals with Williams syndrome. The performance of twenty-eight individuals with Williams syndrome was compared with that of mental age- and gender-matched thirty-two typically developing children on tasks of learning of a visuo-motor sequence by observation or by trial and error. Regardless of the learning modality, acquiring the correct sequence involved three main phases: a detection phase, in which participants discovered the correct sequence and learned how to perform the task; an exercise phase, in which they reproduced the sequence until performance was error-free; an automatization phase, in which by repeating the error-free sequence they became accurate and speedy. Participants with Williams syndrome beneficiated of observational training (in which they observed an actor detecting the visuo-motor sequence in the detection phase, while they performed worse than typically developing children in the exercise and automatization phases. Thus, by exploiting competencies learned by observation, individuals with Williams syndrome detected the visuo-motor sequence, putting into action the appropriate procedural strategies. Conversely, their impaired performances in the exercise phases appeared linked to impaired spatial working memory, while their deficits in automatization phases to deficits in processes increasing efficiency and speed of the response. Overall, observational experience was advantageous for

  11. Patterns of Gram-stained fecal flora as a quick diagnostic marker in patients with severe SIRS.

    Science.gov (United States)

    Shimizu, Kentaro; Ogura, Hiroshi; Tomono, Kazunori; Tasaki, Osamu; Asahara, Takashi; Nomoto, Koji; Morotomi, Masami; Matsushima, Asako; Nakahori, Yasutaka; Yamano, Shuhei; Osuka, Akinori; Kuwagata, Yasuyuki; Sugimoto, Hisashi

    2011-06-01

    The gut is an important target organ of injury during critically ill conditions. Although Gram staining is a common and quick method for identifying bacteria, its clinical application has not been fully evaluated in critically ill conditions. This study's aims were to identify patterns of Gram-stained fecal flora and compare them to cultured bacterial counts and to investigate the association between the patterns and septic complications in patients with severe systemic inflammatory response syndrome (SIRS). Fifty-two patients with SIRS were included whose Gram-stained fecal flora was classified into three patterns. In a diverse pattern, large numbers of multiple kinds of bacteria completely covered the field. In a single pattern, one specific kind of bacteria or fungi predominantly covered the field. In a depleted pattern, most bacteria were diminished in the field. In the analysis of fecal flora, the numbers of total obligate anaerobes in the depleted pattern was significantly lower than those in the diverse pattern and single pattern (p Gram-stained fecal flora can be classified into three patterns and are associated with both cultured bacterial counts and clinical information. Gram-stained fecal bacteria can be used as a quick bedside diagnostic marker for severe SIRS patients.

  12. On Reading Poems: Visual & Verbal Icons in William Carlos Williams' «Landscape With The Fall Of Icarus»

    Directory of Open Access Journals (Sweden)

    Irene R. Fairley

    1981-09-01

    Full Text Available Williams' admiration for Brueghel's landscape is coded in structural and stylistic correspondences between the poem and the painting. Structures in the poem have effects analogous to the use of devices of color, line, foregrounding in the painting. The poem, like the painting, presents a «neutral» scene but subtly insures the reader's involvement. Further, Williams draws a visual statement so that graphic features suggest a global image isomorphic with the motif of descent. Features of the poem, such as line and clause length, syntactic construction, semantic coherence, are discussed as factors that contribute to rapid glancing and increase readability. A study of readers shows their sensitivity to graphic features including the poem's shape, and corroborates the importance of stylistic features.

  13. sir, besoin, dépendance : l'addiction comme (épreuve de la modernité

    Directory of Open Access Journals (Sweden)

    Rita Di Lorenzo

    2016-04-01

    Full Text Available La frontière entre la santé et la pathologie est un lieu fascinant et dangereux, au caractère poreux et riche de familiarités des deux côtés, inavouées et coûteuses. Le terme d’addiction semble s’installer précisément sur cette frontière, gagnant en étendue médiatique ce qu’il perd en précision nosographique ; ainsi, aujourd’hui, nous serions « tous addicts » – au sucre, au téléphone portable, au chocolat, au café, aux soldes, à la chirurgie esthétique, à Facebook, à l’amour, cette liste pouvant être continuée par chacun d’entre nous puisque nous avons tous fait, nous faisons et ferons tous, l’expérience de la force des (mauvaises habitudes, du désir, voire de la pulsion, de l’abus et de la dépendance. Notre société contemporaine semble stimuler cette expérience, en multipliant tant les objets addictogènes que les comportements addictifs : d’une part par le statut attribué aux biens sériels, d’autre part par la dimension pulsionnelle revendiquée dans les habitudes de consommation. Société du plaisir, peut-être plus hédoniste qu’épicurienne, l’époque contemporaine impose le plaisir et son désir comme nouvelle norme. Dès lors, quel est notre rapport à la pulsion, au désir compulsif, au dépassement des limites imposées aux besoins et aux envies socialement acceptables ? Comment notre société régule le désir ? Comment la politique et les médias concourent-ils à le structurer, voire à le prescrire ? Quels mécanismes à l’œuvre dans l’addiction contredisent cette prescription, et surtout : s’agit-il véritablement d’une contradiction ? Notre culture de performance et satisfaction rapides peut effectivement expliquer certaines dépendances induites par leur objet ; néanmoins, la véritable addiction mentale se nourrit d’éléments plus profondément constitutifs de l’identité de l’homme moderne et contemporain : avant tout, la fragilité des acquis, la

  14. Vaccination strategies for SIR vector-transmitted diseases.

    Science.gov (United States)

    Cruz-Pacheco, Gustavo; Esteva, Lourdes; Vargas, Cristobal

    2014-08-01

    Vector-borne diseases are one of the major public health problems in the world with the fastest spreading rate. Control measures have been focused on vector control, with poor results in most cases. Vaccines should help to reduce the diseases incidence, but vaccination strategies should also be defined. In this work, we propose a vector-transmitted SIR disease model with age-structured population subject to a vaccination program. We find an expression for the age-dependent basic reproductive number R(0), and we show that the disease-free equilibrium is locally stable for R(0) ≤ 1, and a unique endemic equilibrium exists for R(0) > 1. We apply the theoretical results to public data to evaluate vaccination strategies, immunization levels, and optimal age of vaccination for dengue disease.

  15. Interview: William and Barbara Christopher.

    Science.gov (United States)

    Teaching Exceptional Children, 1986

    1986-01-01

    Asserting that the biggest mistake educators can make is to set themselves up as experts vis-a-vis parents as amateurs, Barbara and William Christopher emphasize the importance of continued education for the autistic individual and relate their experiences with the educational community as they sought help for their autistic son. (JC)

  16. Sir John Struthers (1823-1899), Professor of Anatomy in the University of Aberdeen (1863-1889), President of the Royal College of Surgeons of Edinburgh (1895-1897).

    Science.gov (United States)

    Kaufman, M H

    2015-11-01

    Between 1841 and 1845 John Struthers attended both the University of Edinburgh and some of the various Extra-mural Schools of Medicine associated with Surgeons' Hall. While a medical student he became a Member of the Hunterian Medical Society of Edinburgh and later was elected one of their Annual Presidents. He graduated with the MD Edin and obtained both the LRCS Edin and the FRCS Edin diplomas in 1845. Shortly afterwards he was invited to teach Anatomy in Dr Handyside's Extra-mural School in Edinburgh. The College of Surgeons certified him to teach Anatomy in October 1847. He had two brothers, and all three read Medicine in Edinburgh. His younger brother, Alexander, died of cholera in the Crimea in 1855 while his older brother James, who had been a bachelor all his life, practised as a Consultant Physician in Leith Hospital, Edinburgh, until his death.When associated with Dr Handyside's Extra-mural School in Edinburgh, John taught Anatomy there until he was elected to the Chair of Anatomy in Aberdeen in 1863. Much of his time was spent in Aberdeen teaching Anatomy and in upgrading the administrative facilities there. He resigned from this Chair in 1889 and subsequently was elected President of Leith Hospital from 1891 to 1897. This was in succession to his older brother, James, who had died in 1891. Later, he was elected President of the Royal College of Surgeons of Edinburgh from 1895 to 1897 and acted as its Vice-President from 1897 until his death in 1899. In 1898, Queen Victoria knighted him. His youngest son, John William Struthers, was the only one of his clinically qualified sons to survive him and subsequently was elected President of the Edinburgh College of Surgeons from 1941 to 1943. © The Author(s) 2014.

  17. 78 FR 50458 - Entergy Nuclear Operations, Inc., James A. Fitzpatrick Nuclear Power Plant, Vermont Yankee...

    Science.gov (United States)

    2013-08-19

    ... Nuclear Operations, Inc., James A. Fitzpatrick Nuclear Power Plant, Vermont Yankee Nuclear Power Station... that the NRC take action with regard to James A. Fitzpatrick Nuclear Power Plant, Vermont Yankee.... Fitzpatrick Nuclear Power Plant (Fitzpatrick), Vermont Yankee Nuclear Power Station (Vermont Yankee), and...

  18. Impulsive vaccination and dispersal on dynamics of an SIR epidemic model with restricting infected individuals boarding transports

    Science.gov (United States)

    Jiao, Jianjun; Cai, Shaohong; Li, Limei

    2016-05-01

    To understand the effect of impulsive vaccination and restricting infected individuals boarding transports on disease spread, we establish an SIR model with impulsive vaccination, impulsive dispersal and restricting infected individuals boarding transports. This SIR epidemic model for two regions, which are connected by transportation of non-infected individuals, portrays the evolvement of diseases. We prove that all solutions of the investigated system are uniformly ultimately bounded. We also prove that there exists globally asymptotically stable infection-free boundary periodic solution. The condition for permanence is discussed. It is concluded that the approach of impulsive vaccination and restricting infected individuals boarding transports provides reliable tactic basis for preventing disease spread.

  19. Review

    NARCIS (Netherlands)

    Lam, H.J.

    1959-01-01

    The well-known Ray Society undertook the publication of this new facsimile of Linnaeus’s most famous and still indispensable botanical work and had it reproduced photographically from an original copy in Linnaeus’s library, later owned by Sir James Edward Smith. It represents the third facsimile

  20. Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination

    Directory of Open Access Journals (Sweden)

    Anqi Miao

    2017-01-01

    Full Text Available A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control.

  1. Rass / Kwame Anthony Appiah ; inglise k. tlk. Joonas Kiik

    Index Scriptorium Estoniae

    Appiah, Kwame Anthony

    1997-01-01

    Rahvastevaheliste erinevuste käsitlusest kirjanduses ja kirjandusteaduses (ka William Shakespeare'i 'Tormis', Walter Scotti 'Ivanhoes' ja James Fenimore Cooperi 'Nahksuka juttudes') ning afroameerika kirjanduse reaktsioonist sellele

  2. Identifying settlements on the SIR-B images of Rimbobujang and the surrounding areas, Sumatra, Indonesia

    Directory of Open Access Journals (Sweden)

    Sutanto .

    2013-07-01

    SIR-B image proves to be a reasonably good tool to identify rural settlement in an open area, especially for that with high density of houses. Its use to identify towns and cities is more recommended.

  3. The urban short story cycle before Joyce: James Stephens’ Here are Ladies

    OpenAIRE

    Brouckmans, Debbie

    2013-01-01

    Published ten years after George Moore’s The Untilled Field (1903) and one year before James Joyce’s Dubliners (1914), James Stephens’ Here are Ladies (1913) consists of short stories, poems and monologues. The work is not often discussed, presumably because it is rather difficult to define. It is usually classified as a collection of short stories, but this neglects the poems and monologues and fails to do justice to the thematic and formal links between the texts. Therefore, I would like to...

  4. James Chadwick Nobel Prize for Physics 1935. Discovery of the neutron; James Chadwick Premio Nobel de Fisica 1935. Descubrimiento del neutron

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    James Chadwick (1981-1974) was a key figure in the field of nuclear science. Through his studies, he researched the disintegration of atoms by bombarding alpha particles and proved the existence of neutrons. For this discovery, he was awarded the Nobel Prize for physics in 1935. (Author)

  5. 78 FR 11857 - Agency Information Collection Activities; Comment Request; William D. Ford Federal Direct Loan...

    Science.gov (United States)

    2013-02-20

    ...; Comment Request; William D. Ford Federal Direct Loan Program (DL) Regulations AGENCY: Department of... in response to this notice will be considered public records. Title of Collection: William D. Ford.... Abstract: The William D. Ford Federal Direct Loan Program regulations cover areas of program administration...

  6. 77 FR 24491 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Science.gov (United States)

    2012-04-24

    ... Smyrna, Tennessee; James A. Campbell, Nashville, Tennessee; William Kent Coleman, Murfreesboro, Tennessee... River Hills, Wisconsin; David J. Lubar, Fox Point, Wisconsin; Susan Lubar Solvang, and Joan P. Lubar...

  7. The James Madison College Student Handbook, 1970-71.

    Science.gov (United States)

    Michigan State Univ., East Lansing. James Madison Coll.

    James Madison College of Michigan State University provides a 4-year, residentially-based program devoted to the study of major social, economic, and political policy problems. It offers 5 fields of concentration: (1) Ethnic and Religious Intergroup Relations Policy Problems; (2) International Relations Policy Problems; (3) Justice, Morality and…

  8. Rorty, Williams, and Davidson: Skepticism and Metaepistemology

    Directory of Open Access Journals (Sweden)

    Christopher Ranalli

    2013-07-01

    Full Text Available We revisit an important exchange on the problem of radical skepticism between Richard Rorty and Michael Williams. In his contribution to this exchange, Rorty defended the kind of transcendental approach to radical skepticism that is offered by Donald Davidson, in contrast to Williams’s Wittgenstein-inspired view. It is argued that the key to evaluating this debate is to understand the particular conception of the radical skeptical problem that is offered in influential work by Barry Stroud, a conception of the skeptical problem which generates metaepistemological ramifications for anti-skeptical theories. In particular, we argue that, contra Williams, Rorty’s view that Davidson was offering a theoretical diagnosis of radical skepticism can be consistently maintained with his transcendental approach.

  9. SIR-A views our environment An Experiment in the Batu Angkal Area, West Kalimantan, Indonesia

    Directory of Open Access Journals (Sweden)

    Sutanto .

    2013-07-01

    Factors affecting the ease of identification are. mainly tonal contrast, shape, size, surface roughness, direction in relation to the illumination, and dielectric constant. Due to the future availability of SIR-B image of Kalimantan, further study is recommended.

  10. Music and Anxiety in Williams Syndrome: A Harmonious or Discordant Relationship?

    Science.gov (United States)

    Dykens, Elisabeth M.; Rosner, Beth A.; Ly, Tran; Sagun, Jaclyn

    2005-01-01

    In this two-part study, we assessed musical involvements in two samples of persons with Williams syndrome compared to others with mental retardation and also related musicality to anxiety and fears in Study 2. Relative to others with mental retardation, those with Williams syndrome were more likely to take music lessons, play an instrument, and…

  11. Religious Studies: The Shaping of a Field and a Guide to Reference Resources.

    Science.gov (United States)

    Lippy, Charles H.

    1992-01-01

    Discusses the development of religious studies as an academic discipline. Examines the work of leading thinkers in the field, including anthropologists Sir James Fraser and Edward Burnett Taylor, sociologist Max Weber, and psychologist Erik Erikson. Identifies some of the many reference works that deal with religious studies. (SG)

  12. Die Another Day, James Bond's smoking over six decades.

    Science.gov (United States)

    Wilson, Nick; Tucker, Anne

    2016-09-01

    We aimed to examine smoking-related content in all 24 James Bond movies in the Eon Productions series from 1962 to 2015. There were favourable downward trends for any smoking by James Bond (p=0.015 for trend), and for tobacco-related spy-gadgetry (p=0.009). Around 20% of Bond's 60 sexual partners smoked in each decade, and most recently in 2012. There were regular mentions of smoking risks to health (starting from 1967) and product placement of branded packs was present in two movies. Overall, the persisting smoking content remains problematic from a public health perspective, especially given the popularity of this movie series. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  13. [Sir Francis Galton: the father of eugenics].

    Science.gov (United States)

    Aubert-Marson, Dominique

    2009-01-01

    Not only was Sir Francis Galton a famous geographer and statistician, he also invented "eugenics" in 1883. Eugenics, defined as the science of improving racial stock, was developed from a new heredity theory, conceived by Galton himself, and from the evolution theory of Charles Darwin, transposed to human society by Herbert Spencer. Galton's eugenics was a program to artificially produce a better human race through regulating marriage and thus procreation. Galton put particular emphasis on "positive eugenics", aimed at encouraging the physically and mentally superior members of the population to choose partners with similar traits. In 1904, he presented his ideas in front of a vast audience of physicians and scientists in London. His widely-publicized lecture served as the starting point for the development of eugenics groups in Europe and the United States during the first half of the 20th century.

  14. Influence of heat conductivity on the performance of RTV SIR coatings with different fillers

    Energy Technology Data Exchange (ETDEWEB)

    Siderakis, K [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, GR-26110 Patras (Greece); Agoris, D [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, Greece, GR-26500, Rion, Greece (Greece); Gubanski, S [High Voltage Laboratory, Department of Electric Power Engineering, Chalmers University of Technology, S-41296, Gothenburg (Sweden)

    2005-10-07

    Room temperature vulcanized silicone rubber (RTV SIR) coatings are employed in order to improve the pollution performance of high voltage ceramic insulators by imparting surface hydrophobicity. In this paper, the performance of three RTV SIR coatings containing different fillers is investigated in a salt-fog test. Alumina trihydrate (ATH) and silica are the fillers included in the formulation, aiming to increase the material endurance to the energy supplied by the surface electrical activity during periods of hydrophobicity loss. The primary action of these fillers is to increase the material heat conductivity, i.e. the amount of energy conducted to the substrate. In addition, in the case of ATH relief is also achieved due to particle decomposition. The results indicate that for the compositions commercially available, where low amounts of fillers are used, and under the conditions of the test, ATH filled coatings performed better than the silica filled ones. This is attributed to ATH decomposition which further relieves the material structure and therefore decelerates material aging.

  15. Prince William Sound, Alaska ESI: HYDRO (Hydrology)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) data for Prince William Sound, Alaska. ESI data characterize estuarine environments and wildlife by...

  16. Prince William Sound, Alaska ESI: INVERT (Invertebrates)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) data for Prince William Sound, Alaska. ESI data characterize estuarine environments and wildlife by...

  17. Who Was the Real William Shakespeare?

    Science.gov (United States)

    Edwards, Michael Todd

    2009-01-01

    This article highlights a project that encourages students to connect reading and mathematics instruction by using a data analysis approach. Students analyze sonnets from statistical, literary, and historical points of view in an effort to uncover the true identity of William Shakespeare. (Contains 10 figures.)

  18. Mr. William Shakespeare and the Internet.

    Science.gov (United States)

    Reeves, Barbara

    2000-01-01

    Describes resources and links on a Web site entitled "Mr. William Shakespeare and the Internet," with suggestions for using them with students. Highlights include: historical context; impact of events/situations on works; motivational/preparatory lessons; reading and understanding Shakespeare; analysis of works; language; assessing other…

  19. James Madison's "Public" As Interpreter of the Constitution.

    Science.gov (United States)

    Dewey, Donald O.

    James Madison's thoughts on various interpretations of the Constitution maintain that public opinion is the ultimate method of legitimizing the document. The Constitution must prevail against mere public opinion, but public opinion may be used to establish the meaning of the Constitution when conflicting interpretations exist. The public good and…

  20. Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging.

    Science.gov (United States)

    Orlandi, Ivan; Pellegrino Coppola, Damiano; Strippoli, Maurizio; Ronzulli, Rossella; Vai, Marina

    2017-01-01

    Nicotinamide (NAM), a form of vitamin B 3 , is a byproduct and noncompetitive inhibitor of the deacetylation reaction catalyzed by Sirtuins. These represent a family of evolutionarily conserved NAD + -dependent deacetylases that are well-known critical regulators of metabolism and aging and whose founding member is Sir2 of Saccharomyces cerevisiae. Here, we investigated the effects of NAM supplementation in the context of yeast chronological aging, the established model for studying aging of postmitotic quiescent mammalian cells. Our data show that NAM supplementation at the diauxic shift results in a phenocopy of chronologically aging sir2Δ cells. In fact, NAM-supplemented cells display the same chronological lifespan extension both in expired medium and extreme Calorie Restriction. Furthermore, NAM allows the cells to push their metabolism toward the same outcomes of sir2Δ cells by elevating the level of the acetylated Pck1. Both these cells have the same metabolic changes that concern not only anabolic pathways such as an increased gluconeogenesis but also respiratory activity in terms both of respiratory rate and state of respiration. In particular, they have a higher respiratory reserve capacity and a lower non-phosphorylating respiration that in concert with a low burden of superoxide anions can affect positively chronological aging. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  1. Nitrites in Urine: MedlinePlus Lab Test Information

    Science.gov (United States)

    ... K. Brunner & Suddarth's Handbook of Laboratory and Diagnostic Tests. 2 nd Ed, Kindle. Philadelphia: Wolters Kluwer Health, Lippincott Williams & Wilkins; c2014. Urinalysis; p. 508–9. James G, ...

  2. MacWilliams Identity for M-Spotty Weight Enumerator

    Science.gov (United States)

    Suzuki, Kazuyoshi; Fujiwara, Eiji

    M-spotty byte error control codes are very effective for correcting/detecting errors in semiconductor memory systems that employ recent high-density RAM chips with wide I/O data (e.g., 8, 16, or 32bits). In this case, the width of the I/O data is one byte. A spotty byte error is defined as random t-bit errors within a byte of length b bits, where 1 le t ≤ b. Then, an error is called an m-spotty byte error if at least one spotty byte error is present in a byte. M-spotty byte error control codes are characterized by the m-spotty distance, which includes the Hamming distance as a special case for t =1 or t = b. The MacWilliams identity provides the relationship between the weight distribution of a code and that of its dual code. The present paper presents the MacWilliams identity for the m-spotty weight enumerator of m-spotty byte error control codes. In addition, the present paper clarifies that the indicated identity includes the MacWilliams identity for the Hamming weight enumerator as a special case.

  3. Global analysis of multi-strains SIS, SIR and MSIR epidemic models

    OpenAIRE

    Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier

    2014-01-01

    International audience; We consider SIS, SIR and MSIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maxim...

  4. Competitive exclusion principle for SIS and SIR models with n strains

    OpenAIRE

    Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier

    2012-01-01

    We consider SIS and SIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maximum of each individual basic re...

  5. Montaigne, Sir Ralph Bankes and other English readers of the Essais.

    OpenAIRE

    O'Brien, John

    2013-01-01

    This article deals with a hitherto unknown and unpublished early modern English manuscript account of Montaigne's Essais by Sir Ralph Bankes (1631?–77) of Kingston Lacy in Dorset. Bankes's account covers a range of features in Montaigne's work: crucial elements of self-portraiture such as judgement, but also his attitude to women and doctors. These characteristics are analysed and compared first with Montaigne's own pronouncements about the aspects Bankes selects and secondly with two other s...

  6. [Vascular malformations in the Williams-Beuren syndrome: report of three new cases].

    Science.gov (United States)

    Sator, Hicham; Rhouni, Fatima Ezzahra; Benjouad, Ibitihale; Rhouni, Fatima Ezzahra; Benjouad, Ibitihale; Dafiri, Rachida; Chat, Latifa

    2016-01-01

    The Williams-Beuren syndrome is a rare genetic disease. It combines classically specific facial dysmorphism, cardiovascular malformations and specific neuropsychological profile. We report three cases of Williams-Beuren syndrome in children with particular emphasis on vascular abnormalities observed on CT angiography and MR angiography.

  7. SIR (Safe Integral Reactor) - reducing size can reduce cost

    International Nuclear Information System (INIS)

    Hayns, M.R.

    1991-01-01

    Traditional engineering economics have favoured the advantages of larger size as a means of reducing specific capital costs and hence unit generating costs. For large and small plants utilising the same concept, e.g. a small four-loop PWR vs a large four-loop PWR with the same number of components, economies of scale are well established. If, however, a smaller plant is sized to take advantage of features which are only feasible at smaller outputs, is of simpler design, with the advantage taken of the simplified design to produce the most cost-effective layout, and incorporates fewer, more easily replaceable components with minimal assembly on site, it is possible to produce a plant which is competitive with larger plant of more traditional design. When 'system' effects, such as better matching of installed capacity to the growth in demand and the fact that a smaller total capacity will be needed to meet a given demand with a specified level of confidence, are taken into account, it can be shown that a utility's overall cash-flow position can be improved with lower associated absolute financial risks. The UK/US Safe Integral Reactor (SIR) is an integral pressurized water reactor in the 300-400 MW(e) range which utilises conventional water reactor technology in a way not feasible at the very large, sizes of recent years. The SIR concept is briefly explained and its technical and economic advantages in terms of simplicity, construction, maintenance, availability, decommissioning, safety and siting described. The results of system analyses which demonstrate the overall financial advantages to a utility are presented. (author)

  8. Procalcitonin, C-reactive protein and serum lactate dehydrogenase in the diagnosis of bacterial sepsis, SIRS and systemic candidiasis.

    Science.gov (United States)

    Miglietta, Fabio; Faneschi, Maria Letizia; Lobreglio, Giambattista; Palumbo, Claudio; Rizzo, Adriana; Cucurachi, Marco; Portaccio, Gerolamo; Guerra, Francesco; Pizzolante, Maria

    2015-09-01

    The aim of this study was to evaluate procalcitonin (PCT), C-reactive protein (CRP), platelet count (PLT) and serum lactate dehydrogenase (LDH) as early markers for diagnosis of SIRS, bacterial sepsis and systemic candidiasis in intensive care unit (ICU) patients. Based on blood culture results, the patients were divided into a sepsis group (70 patients), a SIRS group (42 patients) and a systemic candidiasis group (33 patients). PCT, CRP, LDH and PLT levels were measured on day 0 and on day 2 from the sepsis symptom onset. PCT levels were higher in Gram negative sepsis than those in Gram positive sepsis, although the P value between the two subgroups is not significant (P=0.095). Bacterial sepsis group had higher PCT and CRP levels compared with the systemic candidiasis group, whereas PLT and LDH levels showed similar levels in these two subgroups. The AUC for PCT (AUC: 0.892, P candidiasis groups (P=0.093 N.S.). In conclusion, PCT can be used as a preliminary marker in the event of clinical suspicion of systemic candidiasis; however, low PCT levels (candidiasis and SIRS groups.

  9. Fulltext PDF

    Indian Academy of Sciences (India)

    sharing personal experiences and viewpoints on matters related to teaching and learning science. ... School of Engineering and. Applied Sciences ... borative discovery (with Sir William Ramsay) of the inert elementary gas argon. Rayleigh's ..... J RA Pearson of the Imperial College of Science and Technology in London.

  10. James Webb Space Telescope Optical Telescope Element Mirror Development History and Results

    Science.gov (United States)

    Feinber, Lee D.; Clampin, Mark; Keski-Kuha, Ritva; Atkinson, Charlie; Texter, Scott; Bergeland, Mark; Gallagher, Benjamin B.

    2012-01-01

    In a little under a decade, the James Webb Space Telescope (JWST) program has designed, manufactured, assembled and tested 21 flight beryllium mirrors for the James Webb Space Telescope Optical Telescope Element. This paper will summarize the mirror development history starting with the selection of beryllium as the mirror material and ending with the final test results. It will provide an overview of the technological roadmap and schedules and the key challenges that were overcome. It will also provide a summary or the key tests that were performed and the results of these tests.

  11. Stranger Danger Awareness in Williams Syndrome

    Science.gov (United States)

    Riby, D. M.; Kirk, H.; Hanley, M.; Riby, L. M.

    2014-01-01

    Background: The developmental disorder Williams syndrome (WS) is characterised by a distinctive cognitive profile and an intriguing social phenotype. Individuals with the disorder are often highly social engaging with familiar and unfamiliar people and once in an interaction they often show subtle abnormalities of social behaviour. Atypically…

  12. Looking Backward: James Madison University's General Education Reform.

    Science.gov (United States)

    Reynolds, Charles W.; Allain, Violet Anselmini; Erwin, T. Dary; Halpern, Linda Cabe; McNallie, Robin; Ross, Martha K.

    1998-01-01

    Describes the new general education program at James Madison University (Virginia) and the process by which it was developed. Indicates that the program is organized by five broad areas of knowledge that are defined by interdisciplinary clusters of learning objectives, which in turn were developed using input from every academic department on…

  13. Sir Ronald A. Fisher and the International Biometric Society.

    Science.gov (United States)

    Billard, Lynne

    2014-06-01

    The year 2012 marks the 50th anniversary of the death of Sir Ronald A. Fisher, one of the two Fathers of Statistics and a Founder of the International Biometric Society (the "Society"). To celebrate the extraordinary genius of Fisher and the far-sighted vision of Fisher and Chester Bliss in organizing and promoting the formation of the Society, this article looks at the origins and growth of the Society, some of the key players and events, and especially the roles played by Fisher himself as the First President. A fresh look at Fisher, the man rather than the scientific genius is also presented. © 2014, The International Biometric Society.

  14. 33 CFR 164.43 - Automatic Identification System Shipborne Equipment-Prince William Sound.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Automatic Identification System Shipborne Equipment-Prince William Sound. 164.43 Section 164.43 Navigation and Navigable Waters COAST GUARD... Automatic Identification System Shipborne Equipment—Prince William Sound. (a) Until December 31, 2004, each...

  15. Investigating Environmentally Sustainable Transport Based on DALY weights and SIR Method

    Directory of Open Access Journals (Sweden)

    Hossein Nezamianpour Jahromi

    2012-09-01

    Full Text Available Accessibility is one of the main causes of well-being and growth in contemporary societies. Transportation is the backbone of accessibility systems that lead to the growth of economic and social networks and spatial dispersion of activities. Unfortunately, the adverse effects of transportation have a great impact on the natural and human environment. Since transportation is associated with fossil fuel combustion, it results in emissions of pollutants that cause damage to human health. To save the global eco-system, sustainable development has become an international priority. To deal with the sustainability of transportation systems is an important issue as testified by a growing number of initiatives framed to define and measure sustainability in transportation planning and infrastructure planning as well. The capability of environmental assessment as a sustainability instrument is well known. This study proposes a new approach to rank countries based on environmental sustainability development applying disability adjusted life year (DALY weights for transportation sector emissions. DALY weights consider actual impacts of pollutants on human health. By employing SIR method, a superiority and inferiority ranking method is presented for multiple criteria decision making, the sustainability ranking of a number of European countries is presented. Three various ranking methods extracted from SIR ranking method are discussed and the results and the correlation among them are demonstrated.

  16. Dynamic Behavior for an SIRS Model with Nonlinear Incidence Rate and Treatment

    Directory of Open Access Journals (Sweden)

    Junhong Li

    2013-01-01

    Full Text Available This paper considers an SIRS model with nonlinear incidence rate and treatment. It is assumed that susceptible and infectious individuals have constant immigration rates. We investigate the existence of equilibrium and prove the global asymptotical stable results of the endemic equilibrium. We then obtained that the model undergoes a Hopf bifurcation and existences a limit cycle. Some numerical simulations are given to illustrate the analytical results.

  17. The King James Bible and the Politics of Religious Education: Secular State and Sacred Scripture

    Science.gov (United States)

    Gearon, Liam

    2013-01-01

    This article provides an outline historical-educational analysis of the King James Bible from its 1611 publication through to its four-hundredth anniversary commemoration in 2011. With particular focus on England, the article traces the educational impact of the King James Bible and charts, in the country of its origin, its progressive decline in…

  18. N-acetylcysteine for neuropsychiatric symptoms in a woman with Williams syndrome.

    Science.gov (United States)

    Pineiro, Mildred Lopez; Roberts, Antoinette M; Waxler, Jessica L; Mullett, Jennifer E; Pober, Barbara R; McDougle, Christopher J

    2014-11-01

    Williams syndrome is a relatively rare genetic disorder caused by the hemizygous microdeletion of a region in chromosome 7q11.23. Individuals with Williams syndrome typically present with a highly social, overfriendly, and empathic personality. Comorbid medical and neuropsychiatric disorders are common. Reports of effective pharmacological treatment of associated neuropsychiatric disorders are limited. The authors describe the successful treatment of interfering anger, aggression, and hair-pulling with N-acetylcysteine in a 19-year-old woman with Williams syndrome. The neuropsychiatric symptoms emerged 1 week following an upper gastrointestinal endoscopy, for which fentanyl, midazolam, and propofol were used as anesthetics. The patient's treatment course and hypothesized mechanisms underlying the clinical presentation and symptom resolution are described. © The Author(s) 2014.

  19. Miscellaneous information

    NARCIS (Netherlands)

    Yap, Richard E.; Linnaeus, C.

    1964-01-01

    Mr S. Savage, F.L.S., formerly the Linnean Society’s Librarian and Assistant Secretary, has now completed the catalogue of the Herbarium of the Society’s first President, Sir James Edward Smith, which contains nearly 20,000 sheets. The MS. consists of over 1400 foolscap pages and includes a preface,

  20. Bell's palsy before Bell : Cornelis Stalpart van der Wiel's observation of Bell's palsy in 1683

    NARCIS (Netherlands)

    van de Graaf, RC; Nicolai, JPA

    Bell's palsy is named after Sir Charles Bell (1774-1842), who has long been considered to be the first to describe idiopathic facial paralysis in the early 19th century. However, it was discovered that Nicolaus Anton Friedreich (1761-1836) and James Douglas (1675-1742) preceded him in the 18th

  1. Fading-Figure Tracing in Williams Syndrome

    Science.gov (United States)

    Nagai, Chiyoko; Inui, Toshio; Iwata, Makoto

    2011-01-01

    Williams syndrome (WS) is a neurodevelopmental disorder characterized by severe impairment of visuospatial abilities. Figure-drawing abilities, which are thought to reflect visuospatial abilities, have yet to be fully investigated in WS. The purpose of the present study was to clarify whether drawing abilities differ between WS individuals and…

  2. James Van Allen and His Namesake NASA Mission

    Science.gov (United States)

    Baker, D. N.; Hoxie, V. C.; Jaynes, A.; Kale, A.; Kanekal, S. G.; Li, X.; Reeves, G. D.; Spence, H. E.

    2013-12-01

    In many ways, James A. Van Allen defined and "invented" modern space research. His example showed the way for government-university partners to pursue basic research that also served important national and international goals. He was a tireless advocate for space exploration and for the role of space science in the spectrum of national priorities.

  3. James Madison's Practical Ideals for the 1990s.

    Science.gov (United States)

    Delattre, Edwin J.

    This paper examines recent behavior of public officials at various levels of government in the United States, finds a systemic failure to meet ethical standards, and concludes that the wisdom of James Madison has much applicability to current times. Given his keen perception of human nature, Madison would not be too surprised at today's poor…

  4. Engineering new medicine: an interview with James Collins.

    Science.gov (United States)

    Collins, James

    2010-01-01

    At first glance, the commonality among synthetic gene networks, nerve cell response times and the emergence of antibiotic resistance is obscure. Yet, when speaking with James (Jim) Collins, the relationship becomes clear: all are applications-oriented problems, and all inspire unique approaches from this unusual engineer who is empowered by his freedom to fail.

  5. "To Mediate Relevantly": A Response to James Simpson

    Science.gov (United States)

    Waters, Alan

    2009-01-01

    In Waters (2009), it was contended that, because of its ideological orientation, a good deal of applied linguistics for language teaching (ALLT) fails to "mediate relevantly" between academic and practitioner perspectives. James Simpson's rejoinder to my article (Simpson 2009) attempts to refute its claims. However, in my view, it fails to do so,…

  6. The James Bay Advisory Committee on the Environment annual report, 1990-1991

    International Nuclear Information System (INIS)

    1992-01-01

    The James Bay Advisory Committee on the Environment (JBACE) was established under the James Bay and Northern Quebec Agreement as the preferred, official form for the Quebec and Canadian governments as well as for aboriginal groups and territorial municipalities when they wish to formulate laws and regulations relating to the environment and social milieu of the territory falling under the Agreement. JBACE activities for 1990-91 included action regarding an environmental impact study of the Great Whale hydroelectric development project, a response to provincial hearings on electricity in Quebec, and a study of forest management plans for the James Bay region. In response to a Quebec environmental ministry notice that planned roads and airports for the Great Whale project should have a separate environmental assessment, the JBACE recommended that there should be only one assessment for all aspects of the Great Whale project. The committee also presented a brief regarding its views on hydroelectric megaprojects in Quebec, the need to examine their environmental impacts as a whole, and the need to standardize environmental assessment procedures. 1 fig., 1 tab

  7. The James Bay Advisory Committee on the Environment annual report, 1991-1992

    International Nuclear Information System (INIS)

    1993-01-01

    The James Bay Advisory Committee on the Environment (JBACE) was established under the James Bay and Northern Quebec Agreement as the preferred, official form for the Quebec and Canadian governments as well as for aboriginal groups and territorial municipalities when they wish to formulate laws and regulations relating to the environment and social milieu of the territory falling under the Agreement. JBACE activities for 1991-92 included action regarding an environmental impact study of the Great Whale hydroelectric development project, an environmental assessment of a proposed 735-kV transmission line, language policies under the Agreement, and a study of forest management plans for the James Bay region. In response to a Quebec environmental ministry notice that planned access and accomodation infrastructures for the Great Whale project should have a separate environmental assessment, the JBACE had recommended that there should be only one assessment for all aspects of the Great Whale project. In January 1992, a memorandum of agreement was signed satisfying JBACE's requests on the environmental assessment. 1 fig., 1 tab

  8. Getting a grip on affordances, attention and visual fields

    OpenAIRE

    Linden, Lotje van der; Theeuwes, Jan; Ellis, Rob

    2013-01-01

    van der Linden, L., Theeuwes, J., & Ellis, R. (2012). Getting a grip on affordances, attention, and visual fields. Poster presented at the 2012 William James Graduate School Symposium, Amsterdam, The Netherlands.

  9. 77 FR 43276 - Notice of Proposed Information Collection Requests; Federal Student Aid; William D. Ford Federal...

    Science.gov (United States)

    2012-07-24

    ...; William D. Ford Federal Direct Loan Program General Forbearance Request SUMMARY: Borrowers who receive loans through the William D. Ford Federal Direct Loan Program will use this form to request forbearance... considered public records. Title of Collection: William D. Ford Federal Direct Loan Program General...

  10. Seasonal distribution of Dall's porpoise in Prince William Sound, Alaska

    Science.gov (United States)

    Moran, John R.; O'Dell, Matthew B.; Arimitsu, Mayumi L.; Straley, Janice M.; Dickson, Danielle M. S.

    2018-01-01

    Dall's porpoise, Phocoenoides dalli, are a conspicuous predator in the Prince William Sound ecosystem, yet there has been little effort directed towards monitoring this species since the 1980s, prior to the Exxon Valdez oil spill. We used vessel-based surveys to examine the seasonal distribution of Dall's porpoise in the waters of Prince William Sound during eight years from 2007 to 2015. Over the course of 168 days and 15,653 km of survey effort, 921 Dall's porpoise were encountered in 210 groups. We estimate an encounter rate of 0.061 porpoise/km traveled or 1 porpoise encountered for every 16.5 km traveled. Dall's porpoise were found throughout the year in Prince William Sound, and used a wide range of habitats, including those not considered typical of the species, such as bays, shallow water, and nearshore waters. Dall's porpoise seasonally shifted their center of distribution from the western passages in fall to the bays of the eastern Sound in winter and spring. Dall's porpoises were widely dispersed throughout the Sound in summer. We identified potential Dall's porpoise habitat (depth, slope, and distance from shore) within Prince William Sound using generalized additive models (GAM). Dall's porpoise were found in deeper water during summer and in shallowest water during spring. We propose that their use of novel habitats is a function of reduced predation risk associated with the decline of their main predator, killer whales (Orcinus orca), following the Exxon Valdez oil spill, and the presence of overwintering and spawning Pacific herring (Clupea pallasii). While the size of the Dall's porpoise population within Prince William Sound remains unknown, our encounter rates were lower than those reported in the 1970s. Their high metabolic rate and ubiquitous presence makes them one of the more important, yet understudied, forage fish predators in the region.

  11. Williams-Beuren syndrome associated with single kidney and nephrocalcinosis: a case report.

    Science.gov (United States)

    Abidi, Kamel; Jellouli, Manel; Ben Rabeh, Rania; Hammi, Yousra; Gargah, Tahar

    2015-01-01

    Williams-Beuren syndrome is a rare neurodevelopmental disorder, characterized by congenital heart defects, abnormal facial features, mental retardation with specific cognitive and behavioral profile, growth hormone deficiency, renal and skeletal anomalies, inguinal hernia, infantile hypercalcaemia. We report a case with Williams-Beuren syndrome associated with a single kidney and nephrocalcinosis complicated by hypercalcaemia. A male infant, aged 20 months presented growth retardation associated with a psychomotor impairment, dysmorphic features and nephrocalcinosis. He had also hypercalciuria and hypercalcemia. Echocardiography was normal. DMSA renal scintigraphy showed a single functioning kidney. The FISH generated one ELN signal in 20 metaphases read and found the presence of ELN deletion, with compatible Williams-Beuren syndrome.

  12. 77 FR 47374 - Notice of Proposed Information Collection Requests; Federal Student Aid; William D. Ford Federal...

    Science.gov (United States)

    2012-08-08

    ...; William D. Ford Federal Direct Loan (Direct Loan) Program/ Federal Family Loan (FFEL) Program: Deferment... which borrowers in the William D. Ford Federal Direct Loan (Direct Loan) and Federal Family Education... considered public records. Title of Collection: William D. Ford Federal Direct Loan (Direct Loan) Program...

  13. MRI Amygdala Volume in Williams Syndrome

    Science.gov (United States)

    Capitao, Liliana; Sampaio, Adriana; Sampaio, Cassandra; Vasconcelos, Cristiana; Fernandez, Montse; Garayzabal, Elena; Shenton, Martha E.; Goncalves, Oscar F.

    2011-01-01

    One of the most intriguing characteristics of Williams Syndrome individuals is their hypersociability. The amygdala has been consistently implicated in the etiology of this social profile, particularly given its role in emotional and social behavior. This study examined amygdala volume and symmetry in WS individuals and in age and sex matched…

  14. Attention to Faces in Williams Syndrome

    Science.gov (United States)

    Riby, Deborah M.; Jones, Nicola; Brown, Philippa H.; Robinson, Lucy J.; Langton, Stephen R. H.; Bruce, Vicki; Riby, Leigh M.

    2011-01-01

    Williams syndrome (WS) is associated with distinct social behaviours. One component of the WS social phenotype is atypically prolonged face fixation. This behaviour co-exists with attention difficulties. Attention is multi-faceted and may impact on gaze behaviour in several ways. Four experiments assessed (i) attention capture by faces, (ii)…

  15. Lyapunov functions and global stability for SIR and SEIR models with age-dependent susceptibility

    KAUST Repository

    Korobeinikov, Andrei; Melnik, Andrey V.

    2013-01-01

    We consider global asymptotic properties for the SIR and SEIR age structured models for infectious diseases where the susceptibility depends on the age. Using the direct Lyapunov method with Volterra type Lyapunov functions, we establish conditions for the global stability of a unique endemic steady state and the infection-free steady state.

  16. James Madison High: A School at the Crossroads

    Science.gov (United States)

    Stroup, John T.; Salmonowicz, Michael J.; Broom, Christopher C.

    2007-01-01

    This case tells the story of James Madison High School, which became the epicenter of a debate over the future reorganization and control of large secondary schools in the Los Angeles Unified School District (LAUSD). The LAUSD, recently taken over by the newly elected mayor, was fighting for control of this 3,000-student high school with a charter…

  17. Enough room for Williams and IMF? / Paul Beckman

    Index Scriptorium Estoniae

    Beckman, Paul

    1999-01-01

    Lõppesid Leedu ja USA energeetikakompanii Williams International läbirääkimised Leedu naftakompleksis osaluse omandamise asjus. IMF uurib Leedu majanduslikku arengut, mida tehing Williamsiga komplitseerib

  18. 75 FR 11575 - James A. Fitzpatrick Nuclear Power Plant Environmental Assessment and Finding of No Significant...

    Science.gov (United States)

    2010-03-11

    ... Power Plant Environmental Assessment and Finding of No Significant Impact The U.S. Nuclear Regulatory...), for the operation of the James A. FitzPatrick Nuclear Power Plant (JAFNPP) located in Oswego County... the Final Environmental Statement for the James A. FitzPatrick Nuclear Power Plant, Docket No. 50-333...

  19. ABORDAGEM DIAGNÓSTICA DA SÍNDROME DE WILLIAMS - BEUREN.

    OpenAIRE

    Santos, Marina Machado

    2016-01-01

    As anomalias cromossômicas causam fenótipos específicos e complexos resultantes de desequilíbrios na dose normal de genes localizados em um segmento cromossômico específico, sendo responsáveis por 60 % ou mais das síndromes genéticas identificáveis. A Síndrome de Williams-Beuren (SWB) caracteriza-se por anomalias múltiplas e deficiência intelectual, descrita independentemente por Williams et al. (1961) e por Beuren et al. (1962). A SWB consiste em uma doença genética causada pela microdeleção...

  20. Determination of the Geographical Origin of All Commercial Hake Species by Stable Isotope Ratio (SIR) Analysis.

    Science.gov (United States)

    Carrera, Mónica; Gallardo, José M

    2017-02-08

    The determination of the geographical origin of food products is relevant to comply with the legal regulations of traceability, to avoid food fraud, and to guarantee food quality and safety to the consumers. For these reasons, stable isotope ratio (SIR) analysis using an isotope ratio mass spectrometry (IRMS) instrument is one of the most useful techniques for evaluating food traceability and authenticity. The present study was aimed to determine, for the first time, the geographical origin for all commercial fish species belonging to the Merlucciidae family using SIR analysis of carbon (δ 13 C) and nitrogen (δ 15 N). The specific results enabled their clear classification according to the FAO (Food and Agriculture Organization of the United Nations) fishing areas, latitude, and geographical origin in the following six different clusters: European, North African, South African, North American, South American, and Australian hake species.

  1. Positron-emitting resin microspheres as surrogates of 90Y SIR-Spheres: a radiolabeling and stability study

    International Nuclear Information System (INIS)

    Avila-Rodriguez, Miguel A.; Selwyn, Reed G.; Hampel, Joseph A.; Thomadsen, Bruce R.; DeJesus, Onofre T.; Converse, Alexander K.; Nickles, Robert J.

    2007-01-01

    Commercially available resin microspheres and SIR-Spheres were labeled with metallic positron emitters and evaluated as positron emission tomography (PET) imaging surrogates of 90 Y SIR-Spheres. Radiolabeling was performed using a batch method, and in vitro stability over 24 h was evaluated in saline at physiological pH at 37 o C. The activity per microsphere distribution, as evaluated by autoradiography, showed the activity per microsphere to be proportional to the square radius of the spheres, suggesting surface binding. The in vivo stability of radiolabeling was evaluated in rats by micro-PET imaging after the intravenous injection of labeled microspheres. The different resin microspheres and radionuclides evaluated in this study all showed good radiolabeling efficiency and in vitro stability. However, only resins labeled with 86 Y and 89 Zr proved to have the in vivo stability required for clinical applications

  2. The threshold of a stochastic delayed SIR epidemic model with temporary immunity

    Science.gov (United States)

    Liu, Qun; Chen, Qingmei; Jiang, Daqing

    2016-05-01

    This paper is concerned with the asymptotic properties of a stochastic delayed SIR epidemic model with temporary immunity. Sufficient conditions for extinction and persistence in the mean of the epidemic are established. The threshold between persistence in the mean and extinction of the epidemic is obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number R0 of the deterministic system.

  3. Sir Winston Churchill: treatment for pneumonia in 1943 and 1944.

    Science.gov (United States)

    Vale, J A; Scadding, J W

    2017-12-01

    This paper reviews Churchill's illnesses in February 1943 and August/September 1944 when he developed pneumonia; on the first occasion this followed a cold and sore throat. Churchill was managed at home by Sir Charles Wilson (later Lord Moran) with the assistance of two nurses and the expert advice of Dr Geoffrey Marshall, Brigadier Lionel Whitby and Colonel Robert Drew. A sulphonamide (sulphathiazole on the first occasion) was prescribed for both illnesses. Churchill recovered, and despite his illnesses continued to direct the affairs of State from his bed. On the second occasion, Churchill's illness was not made public.

  4. Florence Jessie Mac Williams (1917-1990)

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 10; Issue 1. Florence Jessie Mac Williams (1917-1990). Featured Scientist Volume 10 Issue 1 January 2005 pp 98-98. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/010/01/0098-0098. Resonance ...

  5. Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively.

    Directory of Open Access Journals (Sweden)

    Inbal Nussbaum

    Full Text Available Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood, although deteriorated stress response is one of the hallmarks of aging. The budding yeast Saccharomyces cerevisiae is a valuable model organism to study the genetics of aging, because yeast ages within days and are amenable to genetic manipulations. As a unicellular organism, yeast has evolved robust systems to respond to environmental challenges. This response is orchestrated largely by the conserved transcription factor Hsf1, which in S. cerevisiae regulates expression of multiple genes in response to diverse stresses. Here we demonstrate that Hsf1 response to heat shock and oxidative stress deteriorates during yeast transition from exponential growth to stationary-phase, whereas Hsf1 activation by glucose starvation is maintained. Overexpressing Hsf1 does not significantly improve heat shock response, indicating that Hsf1 dwindling is not the major cause for Hsf1 attenuated response in stationary-phase yeast. Rather, factors that participate in Hsf1 activation appear to be compromised. We uncover two factors, Yap1 and Sir2, which discretely function in Hsf1 activation by oxidative stress and heat shock. In Δyap1 mutant, Hsf1 does not respond to oxidative stress, while in Δsir2 mutant, Hsf1 does not respond to heat shock. Moreover, excess Sir2 mimics the heat shock response. This role of the NAD+-dependent Sir2 is supported by our finding that supplementing NAD+ precursors improves Hsf1 heat shock response in stationary-phase yeast, especially when combined with expression of excess Sir2. Finally, the combination of excess Hsf1, excess Sir2 and NAD+ precursors rejuvenates the heat shock response.

  6. Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively.

    Science.gov (United States)

    Nussbaum, Inbal; Weindling, Esther; Jubran, Ritta; Cohen, Aviv; Bar-Nun, Shoshana

    2014-01-01

    Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood, although deteriorated stress response is one of the hallmarks of aging. The budding yeast Saccharomyces cerevisiae is a valuable model organism to study the genetics of aging, because yeast ages within days and are amenable to genetic manipulations. As a unicellular organism, yeast has evolved robust systems to respond to environmental challenges. This response is orchestrated largely by the conserved transcription factor Hsf1, which in S. cerevisiae regulates expression of multiple genes in response to diverse stresses. Here we demonstrate that Hsf1 response to heat shock and oxidative stress deteriorates during yeast transition from exponential growth to stationary-phase, whereas Hsf1 activation by glucose starvation is maintained. Overexpressing Hsf1 does not significantly improve heat shock response, indicating that Hsf1 dwindling is not the major cause for Hsf1 attenuated response in stationary-phase yeast. Rather, factors that participate in Hsf1 activation appear to be compromised. We uncover two factors, Yap1 and Sir2, which discretely function in Hsf1 activation by oxidative stress and heat shock. In Δyap1 mutant, Hsf1 does not respond to oxidative stress, while in Δsir2 mutant, Hsf1 does not respond to heat shock. Moreover, excess Sir2 mimics the heat shock response. This role of the NAD+-dependent Sir2 is supported by our finding that supplementing NAD+ precursors improves Hsf1 heat shock response in stationary-phase yeast, especially when combined with expression of excess Sir2. Finally, the combination of excess Hsf1, excess Sir2 and NAD+ precursors rejuvenates the heat shock response.

  7. The influence of percutaneous nephrolithotomy on human systemic stress response, SIRS and renal function.

    Science.gov (United States)

    Shen, Pengfei; Wei, Wuran; Yang, Xiaochun; Zeng, Hao; Li, Xiong; Yang, Jie; Wang, Jia; Huang, Jiaoti

    2010-10-01

    The objective of this study is to investigate the influences of percutaneous nephrolithotomy (PNL) and open surgery nephrolithotomy on the systemic stress response, SIRS and renal function. Forty patients with kidney calculi were enrolled in the study. Twenty cases were randomized to the PNL group and the other twenty cases to the open surgery group. Levels of C-reactive protein (CRP), interleukin-6(IL-6), β(2)-microglobulin (β(2)-MG), respiration rate, heart rate, body temperature and white blood cell counts were examined. CRP and IL-6 were measured in all patients pre-operatively and on post-operative days 1, 3 and 6, respectively. There was significant difference in their pre- and post-operation levels (P PNL group and 12 cases in open surgery group; there was significant difference between the two groups (P 0.05). Urine β(2)-MG levels were also measured. There was significant difference between pre- and the first day post-PNL (P PNL (P > 0.05). There was significant difference between pre- and first and third day post-open surgery (P 0.05). There was significant difference between two groups at the first, third and sixth days (P PNL group and open surgery group to some extent. The degree of stress response of PNL is lower than that of open surgery, proving the advantages of PNL with reference to serum immunology. There were cases in both the groups with SIRS, but the degree of SIRS in PNL group was lesser than the other group. Both the groups have no obvious effect on glomerular filtration function after operation and have effect on renal tubular reabsorption in the early stage after operation; but the recovery of the PNL group is faster than the open surgery group. It is thus shown that PNL is much safer and more feasible and has lesser effect on renal function.

  8. Outcome in Adult Life for People with Williams Syndrome Results from a Survey of 239 Families

    Science.gov (United States)

    Howlin, P.; Udwin, O.

    2006-01-01

    BACKGROUND: Although there has been considerable research into the genotype and phenotype of Williams syndrome, there have been relatively few studies of long-term prognosis. As a preliminary to a more detailed investigation of adults with Williams syndrome, a parental questionnaire was distributed to members of the UK Williams Syndrome…

  9. Coronary ostium occlusion by coronary cusp displacement in Williams syndrome.

    Science.gov (United States)

    Shiohama, Tadashi; Fujii, Katsunori; Ebata, Ryota; Funabashi, Nobusada; Matsumiya, Goro; Saito, Yuko Kazato; Takechi, Fumie; Yonemori, Yoko; Nakatani, Yukio; Shimojo, Naoki

    2016-06-01

    Williams syndrome is a contiguous gene deletion syndrome resulting from a heterozygous deletion on chromosome 7q11.23, and is characterized by distinctive facial features and supravalvular aortic stenosis (SVAS). This syndrome rarely presents unpredictable cardiac death, and yet, as illustrated in the present case, it is still not possible to predict it, even on close monitoring. We herein describe the case of a 6-year-old Japanese girl with Williams syndrome, who had sudden cardiac collapse due to cardiac infarction after pharyngitis. Cardiac failure followed a critical course that did not respond to catecholamine support or heart rest with extracardiac mechanical support. Although marked coronary stenosis was not present, the left coronary cusp abnormally adhered to the aortic wall, which may synergistically cause coronary ostium occlusion with SVAS. Altered hemodynamic state, even that caused by the common cold, may lead to critical myocardial events in Williams syndrome with SVAS. © 2015 Japan Pediatric Society.

  10. A case of Swyer-James syndrome

    International Nuclear Information System (INIS)

    Suzuki, Toshimitsu; Ohtani, Naoshi; Kimura, Sohichi; Izuchi, Rokuro; Iio, Masaaki; Fujinami, Kenji.

    1982-01-01

    Infantile infections are thought to constitute one of the main bases of the etiology of Swyer-James syndrome. This case seems to support the above theory allowing for the anamnesis of the pleuritis at 2 years of age, bronchographical findings - bilateral but markedly left-sided bud-like bronchiectatic changes - and left pulmonary angiographical findings - simultaneous appearance of pulmonary arteries and veins with scarce capillary image. Concerning the ventilation of this syndrome, 133 Xe inhalation test showed a ''Pendelluft'' phenomenon, shift of 133 Xe from the healthy to the affected lung on forced expiration. (author)

  11. Medicinal use of earths and minerals from Hippocrates to Sir Hans Sloane and beyond.

    Science.gov (United States)

    Retsas, Spyros

    2012-12-01

    In 1931 two pharmaceutical drawers containing mineral specimens, belonging to Sir Hans Sloane, the 18th century collector, Royal Physician, President of the Royal Society and of the Royal College of Physicians of London, were found in the Department of Botany of the Natural History Museum (NHM) of London. The drawers, each divided into 49 compartments, contained a total of 107 mineral pharmaceutical specimens, some labelled as mercury or white arsenic. Their registration, identification with the Sloane Manuscript Catalogues and subsequent transfer to the Mineralogy department of the NHM where one of these drawers is now on public display, had been documented by 1935. In antiquity therapeutic empiricism attributed medicinal properties to animal products, plants and minerals, including the soil of specific geographic locations. This communication traces the medicinal use of certain earths and minerals, listed in Sir Hans Sloane's manuscript catalogues, to classical antiquity with a reference to Arsenic compounds, which in our time are finding application in the treatment of acute promyelocytic leukaemia and to Terra Lemnia, a celebrated antidote of repute spanning twenty centuries, also included in the Sloane collections.

  12. 78 FR 24303 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-04-24

    ... exemption applications, FMCSA exempts Christopher R. Anderson (MN), Brent T. Applebury (MO), Joseph A.... Torklidson (WI), Terry R. Washa (NE), Alfred J. Williams (VA), Scott B. Wood (ND), and James L. Zore (IN...

  13. Intelligentsuse jälile pole saadud ka IQ-testide abil / Tiit Kändler

    Index Scriptorium Estoniae

    Kändler, Tiit, 1948-

    2009-01-01

    Uus-Meremaa teadlased, Otago ülikooli professor James R. Flynn ja William W. Dickens Brookings Institutionist on välja selgitanud, et keskkonnafaktorid avaldavad intelligentsusele märkimisväärset mõju

  14. 76 FR 69793 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-11-09

    ... Michael Wayne Gilley William C. Miller Darrell Prather James Jaramillo One applicant, Robert J. Moore, Jr... federal government, state, or any political sub-division of the state. Jimmy Dale Johnson, II Wesley R...

  15. The Threshold of a Stochastic SIRS Model with Vertical Transmission and Saturated Incidence

    Directory of Open Access Journals (Sweden)

    Chunjuan Zhu

    2017-01-01

    Full Text Available The threshold of a stochastic SIRS model with vertical transmission and saturated incidence is investigated. If the noise is small, it is shown that the threshold of the stochastic system determines the extinction and persistence of the epidemic. In addition, we find that if the noise is large, the epidemic still prevails. Finally, numerical simulations are given to illustrate the results.

  16. Traveling waves in a delayed SIR model with nonlocal dispersal and nonlinear incidence

    Science.gov (United States)

    Zhang, Shou-Peng; Yang, Yun-Rui; Zhou, Yong-Hui

    2018-01-01

    This paper is concerned with traveling waves of a delayed SIR model with nonlocal dispersal and a general nonlinear incidence. The existence and nonexistence of traveling waves of the system are established respectively by Schauder's fixed point theorem and two-sided Laplace transform. It is also shown that the spread speed c is influenced by the dispersal rate of the infected individuals and the delay τ.

  17. Successful pregnancy outcome in Swyer-James-Macleod syndrome

    Directory of Open Access Journals (Sweden)

    Chopra Seema

    2008-01-01

    Full Text Available Swyer-James-MacLeod (SJM syndrome is a chronic, progressive lung disease as a result of infection and bronchial obstruction that ultimately leads to emphysema. It is associated with chronic cough, sputum production and recurrent chest infections and is occasionally seen in women of reproductive age. The radiological finding of unilateral hyperlucent lung is considered synonymous with the disease entity.

  18. James J. Gallagher: Man in the White Hat

    Science.gov (United States)

    Jolly, Jennifer L.; Robinson, Ann

    2014-01-01

    In classic Western movies, the good guy could be frequently identified by his trademark white Stetson hat, whereas the bad guy always wore black. James J. Gallagher wore many hats during his career that spanned over six decades; he too would be known as the "man in the white hat,"--trusted to do the right thing. From 1967 to 1970,…

  19. The scientific legacy of William Herschel

    CERN Document Server

    2018-01-01

    This book presents a modern scholarly analysis of issues associated with England’s most famous astronomer, William Herschel. The world’s leading experts on Herschel, discoverer of the planet Uranus, here offer their combined wisdom on many aspects of his life and astronomical research. Solar system topics include comets, Earth’s Moon, and the spurious moons of Uranus, all objects whose observation was pioneered by Herschel.  The contributors examine his study of the structure of the Milky Way and an in-depth look at the development of the front view telescopes he built. The popular subject of extraterrestrial life is looked at from the point of view of both William Herschel and his son John, both of whom had an interest in the topic. William’s personal development through the educational system of the late eighteenth-century is also explored, and the wide range of verse and satire in various languages associated with his discoveries is collected here for the first time. Hershel worked at a time of i...

  20. REHISTORIAR LA BIOÉTICA EN LATINOAMÉRICA: LA CONTRIBUCIÓN DE JAMES DRANE RE-HISTORIAR A BIOÉTICA NA AMÉRICA LATINA: A CONTRIBUIÇÃO DE JAMES DRANE REMAKING BIOETHICS' HISTORY IN LATIN AMERICA: JAMES DRANE'S CONTRIBUTION

    Directory of Open Access Journals (Sweden)

    Fernando Lolas Stepke

    2005-01-01

    Full Text Available Este artículo presenta la persona y la obra de James Drane en su relación con la bioética en Latinoamérica. Tras un breve examen de su carrera y publicaciones, se destaca la creación de un centro de estudios en Edinboro University of Pennsylvania, legado de la filantropía de Russell B. Roth y su familia, que perpetuará el espíritu de interrogación libre y lealtad a sus principios que Drane ha mantenido a lo largo de su vidaEste artigo apresenta a pessoa e a obra de James Drane relacionada com a bioética na América Latina. Após um breve exame de sua carreira e publicações, destaca-se a criação de um centro de estudo na Edinboro Univerisity na Pensilvânia (EUA, legado da filantropia de Russell B. Roth e sua família. Este centro perpetuará o espírito de livre pensador e lealdade aos seus princípios que Drane tem defendido ao longo de sua vidaThis article presents the person and work of James Drane in their relation to bioethics in Latin America. After a brief analysis of his career and publications, the establishment of a study center at the Edinboro University of Pennsylvania is underscored, a legacy of the late Russell B. Roth and his family, which will perpetuate the spirit of free inquiry and loyalty to his principles that Drane has kept throughout his life

  1. Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90α in Severe Sepsis and SIRS

    Directory of Open Access Journals (Sweden)

    K. Vardas

    2014-01-01

    Full Text Available Objective. To evaluate the early heat shock protein (HSP and hormonal stress response of intensive care unit (ICU patients with severe sepsis/septic shock (SS or systemic inflammatory response syndrome (SIRS compared to healthy subjects (H. Methods. Patients with early (first 48 hrs SS (n=29 or SIRS (n=29 admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72 and interleukins. Mean fluorescence intensity (MFI values for intracellular HSPs (iHSP72, iHSP90α were measured using 4-colour flow-cytometry. Results. Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H (P<0.003. ACTH and eHSP72 were significantly higher in SS and SIRS compared to H (P<0.005. SS monocytes expressed lower iHSP72 MFI levels compared to H (P=0.03. Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate (P<0.05. In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10. Conclusion. Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.

  2. Holocene deposition and megathrust splay fault geometries within Prince William Sound, Alaska

    Science.gov (United States)

    Finn, S.; Liberty, L. M.; Haeussler, P. J.; Pratt, T. L.

    2011-12-01

    New high resolution sparker seismic reflection data, in conjunction with reprocessed legacy seismic data, provide the basis for a new fault, fold, and Holocene sediment thickness database for Prince William Sound, Alaska. Additionally, legacy airgun seismic data in Prince William Sound and the Gulf of Alaska tie features on these new sparker data to deeper portions of megathrust splay faults. We correlate regionally extensive bathymetric lineaments within Prince William Sound to megathrust splay faults, such as the ones that ruptured in the 1964 M9.2 earthquake. Lastly, we estimate Holocene sediment thickness within Prince William Sound to better constrain the Holocene fault history throughout the region. We identify three seismic facies related to Holocene, Quaternary, and Tertiary strata that are crosscut by numerous high angle normal faults in the hanging wall of the megathrust splay faults. The crustal-scale seismic reflection profiles show splay faults emerging from 20 km depth between the Yakutat block and North American crust and surfacing as the Hanning Bay and Patton Bay faults. A change in exhumation rates, slip rates, and fault orientation appears near Hinchinbrook that we attribute to differences in subducted slab geometry. Based on our slip rate analysis, we calculate average Holocene displacements of 20 m and 100 m in eastern and western Prince William Sound, respectively. Landward of two splay faults exposed on Montague Island, we observe subsidence, faulting, and landslides that record deformation associated with the 1964 and older megathrust earthquakes.

  3. March 1964 Prince William Sound, USA Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Prince William Sound magnitude 9.2 Mw earthquake on March 28, 1964 at 03:36 GMT (March 27 at 5:36 pm local time), was the largest U.S. earthquake ever recorded...

  4. Attentional Disengagement in Adults with Williams Syndrome

    Science.gov (United States)

    Lense, Miriam D.; Key, Alexandra P.; Dykens, Elisabeth M.

    2011-01-01

    Williams syndrome (WS) is a neurodevelopmental disorder characterized by a distinctive behavioral and cognitive profile, including widespread problems with attention. However, the specific nature of their attentional difficulties, such as inappropriate attentional allocation and/or poor attentional disengagement abilities, has yet to be…

  5. James Stirling Regionalismo y modernidad

    Directory of Open Access Journals (Sweden)

    Javier de Esteban Garbayo

    2015-05-01

    Full Text Available ResumenEn los años treinta, la arquitectura moderna se había introducido en los más remotos lugares del mundo enfrentándose con la infinita idiosincrasia de lo local, y al mismo tiempo, el arquitecto, sintiendo las limitaciones de su estilo e intentando ampliar su vocabulario, se embarcó en un proceso de difusión, asimilación y personalización.La idea de una renovada época después de la posguerra británica, sería compartida por una joven generación de arquitectos con el fin de encontrar una nueva forma de modernidad.Si en sus proyectos domésticos de mediados de los cincuenta, James Stirling partió de una aproximación al regionalismo y a la 'tradición funcional' con el fin de renovar el lenguaje moderno, no abandonaría la idea 'programática' inicial de entender la arquitectura desde una consistencia formal y una lógica que combinaba 'una síntesis común del pasado reciente y una certera actitud hacia el futuro'. AbstractThirties, modern architecture had percolated into remote corners of the world, encountering the infinite idiosyncrasies of locality, and, at the same time, Architects, feelings the limitations of their style and becoming intent upon extending their vocabulary, embarked upon a process of diffusion, assimilation and personalitation.The idea of a renewed period after British postwar, was shared for a new young architects generationto find a new way of modernity.While in his mid fifties housing projects, James Stirling approached to 'regionalism' and 'the functional tradition' to renew the modern language, he wouldn't reject the programmatic idea to understand architecture from a logic and formal consistency that combine 'a common synthesis of the recent past and a certain attitude toward the future'.

  6. Sleep-EEG in dizygotic twins discordant for Williams syndrome.

    Science.gov (United States)

    Bódizs, Róbert; Gombos, Ferenc; Szocs, Katalin; Réthelyi, János M; Gerván, Patrícia; Kovács, Ilona

    2014-01-30

    Reports on twin pairs concordant and discordant for Williams syndrome were published before, but no study unravelled sleep physiology in these cases yet. We aim to fill this gap by analyzing sleep records of a twin pair discordant for Williams syndrome extending our focus on presleep wakefulness and sleep spindling. We performed multiplex ligation-dependent probe amplification of the 7q11.23 region of a 17 years old dizygotic opposite-sex twin pair discordant for Williams syndrome. Polysomnography of laboratory sleep at this age was analyzed and followed-up after 1.5 years by ambulatory polysomnography. Sleep stages scoring, EEG power spectra and sleep spindle analyses were carried out. The twin brother showed reduced levels of amplification for all of the probes in the 7q11.23 region indicating a typical deletion spanning at least 1.038 Mb between FKBP6 and CLIP2. The results of the twin sister showed normal copy numbers in the investigated region. Lower sleep times and efficiencies, as well as higher slow wave sleep percents of the twin brother were evident during both recordings. Roughly equal NREM, Stage 2 and REM sleep percents were found. EEG analyses revealed state and derivation-independent decreases in alpha power, lack of an alpha spectral peak in presleep wakefulness, as well as higher NREM sleep sigma peak frequency in the twin brother. Faster sleep spindles with lower amplitude and shorter duration characterized the records of the twin brother. Spectra show a striking reliability and correspondence between the two situations (laboratory vs. home records). Alterations in sleep and specific neural oscillations including the alpha/sigma waves are inherent aspects of Williams syndrome.

  7. Auditory Attraction: Activation of Visual Cortex by Music and Sound in Williams Syndrome

    Science.gov (United States)

    Thornton-Wells, Tricia A.; Cannistraci, Christopher J.; Anderson, Adam W.; Kim, Chai-Youn; Eapen, Mariam; Gore, John C.; Blake, Randolph; Dykens, Elisabeth M.

    2010-01-01

    Williams syndrome is a genetic neurodevelopmental disorder with a distinctive phenotype, including cognitive-linguistic features, nonsocial anxiety, and a strong attraction to music. We performed functional MRI studies examining brain responses to musical and other types of auditory stimuli in young adults with Williams syndrome and typically…

  8. Konstruksi Realitas Pengguna Ponsel Cerdas Berdasarkan Pesan Penempatan Merek dalam Film James Bond: Spectre

    OpenAIRE

    Hafiz, M. Faisal

    2016-01-01

    This study entitled "Construction of Reality of Smartphone User Based on Branding Placement Message in James Bond: Spectre Film". The research is going to examine the relations between the process of branding placement of Sony Xperia Z5 to the movie-viewer who use smartphone from a variety of backgrounds. Researcher focus on how smartphone users adapt to their social needs, how subjective meaning of Sony Xperia Z5 upon the branding placement message in James Bond: Spectre, a...

  9. Florence Jessie MacWilliams (1917-1990)

    Indian Academy of Sciences (India)

    famous mathematician Oscar Zariski, well known for his work in algebraic geometry, at. Johns Hopkins University, following him to Harvard University to study with him for a year. There was a break in her studies for many years following her marriage in 1941 to. W al ter Mac Williams, an engineer, and the birth and raising of ...

  10. THE JAMES MADISON WOOD QUADRANGLE, STEPHENS COLLEGE, COLUMBIA, MISSOURI.

    Science.gov (United States)

    MCBRIDE, WILMA

    THE JAMES MADISON WOOD QUADRANGLE AT STEPHENS COLLEGE IS A COMPLEX OF BUILDINGS DESIGNED TO MAKE POSSIBLE A FLEXIBLE EDUCATIONAL ENVIRONMENT. A LIBRARY HOUSES A GREAT VARIETY OF AUDIO-VISUAL RESOURCES AND BOOKS. A COMMUNICATION CENTER INCORPORATES TELEVISION AND RADIO FACILITIES, A FILM PRODUCTION STUDIO, AND AUDIO-VISUAL FACILITIES. THE LEARNING…

  11. Prince William Sound, Alaska ESI: FISH (Fish Polygons)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) data for Prince William Sound, Alaska. ESI data characterize estuarine environments and wildlife by...

  12. Prince William Sound, Alaska ESI: NESTS (Bird Nests)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) data for Prince William Sound, Alaska. ESI data characterize estuarine environments and wildlife by...

  13. Doctors, disease and James Joyce.

    Science.gov (United States)

    Kaplan, Robert M

    2008-08-01

    The Irish author James Joyce is regarded as the greatest modernist writer of his time. His works, notably The Dead, A Portrait of the Artist as a Young Man, Ulysses and Finnegans Wake--are intensely autobiographic including meticulous descriptions of illness and states of health--no surprise in view of Joyce's medical history and hypochondria. The Dead revolves around the tragic love of a doomed tubercular youth. Ulysses has a graphic description of Mary Joyce-s death, a funeral and a birth; Stephen Dedalus, the character based on Joyce, attends a drinking session with medical students at the lying-in hospital just as Joyce had done as a student; references to syphilis, alcoholism and other illnesses abound.

  14. [Delocalizing the mind. Peirce, James, Wittgenstein, Descombes].

    Science.gov (United States)

    Chauviré, Christiane

    2010-01-01

    The cognitive sciences have breathed fresh air into the old problem of localizing mental functions, which was often laughed off. Regarding the most philosophical form of the question on the localization of the mind, authors such as Peirce, James, Wittgenstein, and most recently Descombes have imagined delocalizing the mind in order to spread the conviction that the idea itself of a location of the mental is meaningless and to criticize the localisationism of today's cognitive scientists.

  15. The threshold of a stochastic delayed SIR epidemic model with vaccination

    Science.gov (United States)

    Liu, Qun; Jiang, Daqing

    2016-11-01

    In this paper, we study the threshold dynamics of a stochastic delayed SIR epidemic model with vaccination. We obtain sufficient conditions for extinction and persistence in the mean of the epidemic. The threshold between persistence in the mean and extinction of the stochastic system is also obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number Rbar0 of the deterministic system. Results show that time delay has important effects on the persistence and extinction of the epidemic.

  16. Resonance – Journal of Science Education | News

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 1. Issue front cover thumbnail Issue back cover thumbnail. Volume 14, Issue 1. January 2009, pages 1-100. pp 1-2 Editorial. Editorial · S Mahadevan · More Details Fulltext PDF. pp 3-5 Article-in-a-Box. Sir James Lighthill · Renuka Ravindran.

  17. James Weldon Johnson and the Speech Lab Recordings

    Directory of Open Access Journals (Sweden)

    Chris Mustazza

    2016-03-01

    Full Text Available On December 24, 1935, James Weldon Johnson read thirteen of his poems at Columbia University, in a recording session engineered by Columbia Professor of Speech George W. Hibbitt and Barnard colleague Professor W. Cabell Greet, pioneers in the field that became sociolinguistics. Interested in American dialects, Greet and Hibbitt used early sound recording technologies to preserve dialect samples. In the same lab where they recorded T.S. Eliot, Gertrude Stein, and others, James Weldon Johnson read a selection of poems that included several from his seminal collection God’s Trombones and some dialect poems. Mustazza has digitized these and made them publicly available in the PennSound archive. In this essay, Mustazza contextualizes the collection, considering the recordings as sonic inscriptions alongside their textual manifestations. He argues that the collection must be heard within the frames of its production conditions—especially its recording in a speech lab—and that the sound recordings are essential elements in an hermeneutic analysis of the poems. He reasons that the poems’ original topics are reframed and refocused when historicized and contextualized within the frame of The Speech Lab Recordings.

  18. William Shakespeare’s“Hamlet”and Oedipus Complex

    Institute of Scientific and Technical Information of China (English)

    迪丽努尔

    2014-01-01

    “Hamlet”is one of the great dramas of William Shakespeare. This paper by describing the relationship between Hamlet and his mother, the Ghost and his uncle, tries to approve that Oedipus complex is the main reason of Hamlet’s kil ing his uncle.

  19. De wereld in 18 lessen: Christopher Williams

    NARCIS (Netherlands)

    Berrebi, S.

    2011-01-01

    Hij is een echte artist’s artist, de conceptuele fotograaf Christopher Williams. Sinds hij in Duitsland woont en werkt, vindt zijn afgewogen werk, dat de fotografie tegelijk eert en ondervraagt, steeds makkelijker onderdak in Europese kunstinstituten, zoals dit voorjaar bij Museum Dhondt-Dhaenens in

  20. A case of William's syndrome associated peripheral pulmonary arterial stenosis

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Kyung Hwa; Hwang, Mi Soo; Kim, Sun Yong; Chang, Jae Chun; Park, Bok Hwan [College of Medicine, Yeungam University, Daegu (Korea, Republic of)

    1988-06-15

    William's syndrome, in order to more completely delineate the total spectrum of the disorder, indicates that 'infantile hypercalcemia', 'peculiar facies' and 'supravalvular aortic stenosis.' In has other many vascular anomalies, such as peripheral pulmonary arterial stenosis, coronary arterial stenosis, celiac arterial stenosis, and renal aterial stenosis. Only 32% of the patients have evidence of supravalvular aortic stenosis. And it is very rare disease entity that has been reported rarely in Korea. Recently authors experienced a case that was questioned William's syndrome with peripheral pulmonary arterial stenosis, clinically and preliminary radiologically and this case was confirmed by operation. Here we report a case of William's syndrome with peripheral pulmonary arterial stenosis and reviewed literatures.

  1. 75 FR 44720 - Safety Zone; Live-Fire Gun Exercise, M/V Del Monte, James River, VA

    Science.gov (United States)

    2010-07-29

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2010-0585] RIN 1625-AA00 Safety Zone; Live-Fire Gun Exercise, M/V Del Monte, James River, VA AGENCY: Coast Guard, DHS... follows: Sec. 165.T05-0585 Safety Zone; Live-Fire Gun Exercise, M/V Del Monte, James River, VA (a...

  2. An individual-based approach to SIR epidemics in contact networks.

    Science.gov (United States)

    Youssef, Mina; Scoglio, Caterina

    2011-08-21

    Many approaches have recently been proposed to model the spread of epidemics on networks. For instance, the Susceptible/Infected/Recovered (SIR) compartmental model has successfully been applied to different types of diseases that spread out among humans and animals. When this model is applied on a contact network, the centrality characteristics of the network plays an important role in the spreading process. However, current approaches only consider an aggregate representation of the network structure, which can result in inaccurate analysis. In this paper, we propose a new individual-based SIR approach, which considers the whole description of the network structure. The individual-based approach is built on a continuous time Markov chain, and it is capable of evaluating the state probability for every individual in the network. Through mathematical analysis, we rigorously confirm the existence of an epidemic threshold below which an epidemic does not propagate in the network. We also show that the epidemic threshold is inversely proportional to the maximum eigenvalue of the network. Additionally, we study the role of the whole spectrum of the network, and determine the relationship between the maximum number of infected individuals and the set of eigenvalues and eigenvectors. To validate our approach, we analytically study the deviation with respect to the continuous time Markov chain model, and we show that the new approach is accurate for a large range of infection strength. Furthermore, we compare the new approach with the well-known heterogeneous mean field approach in the literature. Ultimately, we support our theoretical results through extensive numerical evaluations and Monte Carlo simulations. Published by Elsevier Ltd.

  3. Isonicotinamide Enhances Sir2 Protein-mediated Silencing and Longevity in Yeast by Raising Intracellular NAD+ Concentration*

    Science.gov (United States)

    McClure, Julie M.; Wierman, Margaret B.; Maqani, Nazif; Smith, Jeffrey S.

    2012-01-01

    Sirtuins are an evolutionarily conserved family of NAD+-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD+ concentration through the combined action of NAD+ biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD+ precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the nicotinamidase Pnc1 converts NAM to nicotinic acid (NA), which is then used as a substrate by the NAD+ salvage pathway enzyme NA phosphoribosyltransferase (Npt1). Isonicotinamide (INAM) is an isostere of NAM that stimulates yeast Sir2 deacetylase activity in vitro by alleviating the NAM inhibition. In this study, we determined that INAM stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD+ concentration. INAM enhanced normal silencing at the rDNA locus but only partially suppressed the silencing defects of an npt1Δ mutant. Yeast cells grown in media lacking NA had a short replicative life span, which was extended by INAM in a SIR2-dependent manner and correlated with increased NAD+. The INAM-induced increase in NAD+ was strongly dependent on Pnc1 and Npt1, suggesting that INAM increases flux through the NAD+ salvage pathway. Part of this effect was mediated by the NR salvage pathways, which generate NAM as a product and require Pnc1 to produce NAD+. We also provide evidence suggesting that INAM influences the expression of multiple NAD+ biosynthesis and salvage pathways to promote homeostasis during stationary phase. PMID:22539348

  4. Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.

    Science.gov (United States)

    McClure, Julie M; Wierman, Margaret B; Maqani, Nazif; Smith, Jeffrey S

    2012-06-15

    Sirtuins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD(+) concentration through the combined action of NAD(+) biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD(+) precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the nicotinamidase Pnc1 converts NAM to nicotinic acid (NA), which is then used as a substrate by the NAD(+) salvage pathway enzyme NA phosphoribosyltransferase (Npt1). Isonicotinamide (INAM) is an isostere of NAM that stimulates yeast Sir2 deacetylase activity in vitro by alleviating the NAM inhibition. In this study, we determined that INAM stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD(+) concentration. INAM enhanced normal silencing at the rDNA locus but only partially suppressed the silencing defects of an npt1Δ mutant. Yeast cells grown in media lacking NA had a short replicative life span, which was extended by INAM in a SIR2-dependent manner and correlated with increased NAD(+). The INAM-induced increase in NAD(+) was strongly dependent on Pnc1 and Npt1, suggesting that INAM increases flux through the NAD(+) salvage pathway. Part of this effect was mediated by the NR salvage pathways, which generate NAM as a product and require Pnc1 to produce NAD(+). We also provide evidence suggesting that INAM influences the expression of multiple NAD(+) biosynthesis and salvage pathways to promote homeostasis during stationary phase.

  5. Microstrip Cross-coupled Interdigital SIR Based Bandpass Filter

    Directory of Open Access Journals (Sweden)

    R. K. Maharjan

    2012-09-01

    Full Text Available A simple and compact 4.9 GHz bandpass filter for C-band applications is proposed. This paper presents a novel microstrip cross-coupled interdigital half-wavelength stepped impedance resonator (SIR based bandpass filter (BPF.The designed structure is similar to that of a combination of two parallel interdigital capacitors. The scattering parameters of the structure are measured using vector network analyzer (VNA. The self generated capacitive and inductive reactances within the interdigital resonators exhibited in a resonance frequency of 4.9 GHz. The resonant frequency and bandwidth of the capacitive cross-coupled resonator is directly optimized from the physical arrangement of the resonators. The measured insertion loss (S21 and return loss (S11 were 0.3 dB and 28 dB, respectively, at resonance frequency which were almost close to the simulation results.

  6. Word-Preserving Arts: Material Inscription, Ekphrasis, and Spatial Form in the Later Work of William Wordsworth

    DEFF Research Database (Denmark)

    Simonsen, Peter

    William Wordsworth, posterity, reading, material inscription, ekphrasis, description, sonnet, portraiture......William Wordsworth, posterity, reading, material inscription, ekphrasis, description, sonnet, portraiture...

  7. Applications of Artificial Intelligence to the Strategic Defense Initiative’s Battle Management/Command and Control Objective.

    Science.gov (United States)

    1985-09-01

    technology issue is expected to take years of research (20:11). According to Lt Gen James A. Abrahamson, director of the SDI organization heading up...from occurring (14:79). A Wqhite House Panel known as the (Dr. James ) Fletcher Defensive Technologies Study Group has pointed out that, in the past...Handbook of Artificial Intelligence. Volume I. Los Altos CA: WilliamKaufmann Inc., 1981. 5. Basden , Andrew. "On the Application of Expert Systems,N

  8. ‘Historical narratives and historical desires: re-evaluating American art criticism of the mid-nineteenth century’: Karen Georgi, Critical Shift: Rereading Jarves, Cook, Stillman, and the Narratives of Nineteenth-Century American Art, The Pennsylvania State University Press, 2013

    OpenAIRE

    Emily Gephart

    2014-01-01

    Striving to distinguish their authority as and demonstrate their professionalism, art critics James Jackson Jarves, Clarence Cook, and William James Stillman wrote exhibition reviews, essays, and increasingly self-conscious histories of American art and artists in the mid-nineteenth century. Whereas their writing has often been employed to establish a model of opposed pre- and post-war periodization in American art, Karen Georgi challenges this view, re-evaluating the rhetorical structures t...

  9. M. Pirgerou on D. Izzo and C. Martinez’s Revisionary Interventions into Henry James

    Directory of Open Access Journals (Sweden)

    2009-07-01

    Full Text Available Donatella Izzo and Carlo Martinez. Revisionary Interventions Into Henry James. Eds. Napoli, 2008. Revisionary Interventions into Henry James is a compilation of a series of papers presented at a colloquium which took place at Università Orientale in Naples, Italy, on October 27, 2006. In her introduction to the volume, Donatella Izzo acknowledges the “rather blatant plagiarism” (7 which lent the book its title.  The borrowing, of course, refers to Donald Pease’s landmark Revisionary Interve...

  10. Sir Charles Alfred Ballance (1856-1936) and the introduction of facial nerve crossover anastomosis in 1895

    NARCIS (Netherlands)

    Van de Graaf, Robert C.; Ijpma, Frank F. A.; Nicolai, Jean-Philippe A.

    Sir Charles Ballance (1856-1936) was the first surgeon in history to perform a facial nerve crossover anastomosis in 1895. Although, recently, several papers on the history of facial nerve surgery have been published, little is known about this historically important operation, the theoretical

  11. How Would Blackstone Teach Today's Law Students with Learning Disabilities?: A Proposal

    Science.gov (United States)

    Schmitz, Suzanne J.

    2007-01-01

    Although Sir William Blackstone would not have known if he had been lecturing to students with learning disabilities, today's law professors are. Law schools are legally required to accommodate students with learning disabilities unless the requested accommodation would alter the fundamental nature of the program. Courts give great deference to…

  12. In Memoriam: James Harlan Steele (1913—2013)

    Centers for Disease Control (CDC) Podcasts

    2014-05-19

    Drs. Jennifer McQuiston and Casey Barton Behravesh talk with Dr. Myron Schultz about the legendary Dr. James Harlan Steele.  Created: 5/19/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 5/20/2014.

  13. The β-1,3-glucanosyltransferase Gas1 regulates Sir2-mediated rDNA stability in Saccharomyces cerevisiae.

    Science.gov (United States)

    Ha, Cheol Woong; Kim, Kwantae; Chang, Yeon Ji; Kim, Bongkeun; Huh, Won-Ki

    2014-07-01

    In Saccharomyces cerevisiae, the stability of highly repetitive rDNA array is maintained through transcriptional silencing. Recently, a β-1,3-glucanosyltransferase Gas1 has been shown to play a significant role in the regulation of transcriptional silencing in S. cerevisiae. Here, we show that the gas1Δ mutation increases rDNA silencing in a Sir2-dependent manner. Remarkably, the gas1Δ mutation induces nuclear localization of Msn2/4 and stimulates the expression of PNC1, a gene encoding a nicotinamidase that functions as a Sir2 activator. The lack of enzymatic activity of Gas1 or treatment with a cell wall-damaging agent, Congo red, exhibits effects similar to those of the gas1Δ mutation. Furthermore, the loss of Gas1 or Congo red treatment lowers the cAMP-dependent protein kinase (PKA) activity in a cell wall integrity MAP kinase Slt2-dependent manner. Collectively, our results suggest that the dysfunction of Gas1 plays a positive role in the maintenance of rDNA integrity by decreasing PKA activity and inducing the accumulation of Msn2/4 in the nucleus. It seems that nuclear-localized Msn2/4 stimulate the expression of Pnc1, thereby enhancing the association of Sir2 with rDNA and promoting rDNA stability. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  14. Sir Robert Ball: Victorian Astronomer and Lecturer par excellence

    Science.gov (United States)

    Jones, R. I. G.

    2005-12-01

    Between 1875 and 1910 Sir Robert Stawell Ball gave an estimated 2,500 lectures in towns and cities all over the British Isles and abroad. This paper traces his lecturing career from its beginnings in Ireland to the triumphs of the Royal Institution, and on lecture tours in the United States of America. After a period in mathematics and mechanics, he became a populariser of science, especially astronomy, and found fame and fortune among the working classes and the aristocracy. What motivated him to tireless travels is uncertain, but it might have been that it was rewarding, financially and to his reputation. Whatever his motives, contemporary accounts are clear that BallÕs lectures were extremely popular and well-received.

  15. Colour discrimination and categorisation in Williams syndrome.

    Science.gov (United States)

    Farran, Emily K; Cranwell, Matthew B; Alvarez, James; Franklin, Anna

    2013-10-01

    Individuals with Williams syndrome (WS) present with impaired functioning of the dorsal visual stream relative to the ventral visual stream. As such, little attention has been given to ventral stream functions in WS. We investigated colour processing, a predominantly ventral stream function, for the first time in nineteen individuals with Williams syndrome. Colour discrimination was assessed using the Farnsworth-Munsell 100 hue test. Colour categorisation was assessed using a match-to-sample test and a colour naming task. A visual search task was also included as a measure of sensitivity to the size of perceptual colour difference. Results showed that individuals with WS have reduced colour discrimination relative to typically developing participants matched for chronological age; performance was commensurate with a typically developing group matched for non-verbal ability. In contrast, categorisation was typical in WS, although there was some evidence that sensitivity to the size of perceptual colour differences was reduced in this group. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. The Contributions of James Moir to Physical Chemistry | Loyson ...

    African Journals Online (AJOL)

    James Moir was a pioneering chemist in the early 1900s who played a leading role in various chemical societies in South Africa. Although he was mainly an organic chemist, he was a very good all-round chemist, whose analytical and organic activities have already been covered in this journal. This article examines his ...

  17. Navy Enterprise Resource Planning Program: Governance Challenges in Deploying an Enterprise-Wide Information Technology System in the Department of the Navy

    Science.gov (United States)

    2010-12-01

    Douglas E. Brinkley, Support Advisor _____________________________________ William R. Gates, Dean Graduate School of Business and...Washington, DC: Assistant Secretary of the Navy for Research, Development and Acquisition. Blackstone , John H., and James F. Cox. 2005. APICS Dictionary

  18. Any Time, Every Place: The Networked Societies of War Fighters in a Battlespace of Flows

    Science.gov (United States)

    2015-10-01

    Power Journal Blair Notes 1. William H. McRaven, Spec Ops: Case Studies in Special Operations Warfare: Theory and Practice (New York: Presidio Press...and Dr. William Thiesen and others, various interviews by the author, US Coast Guard Historian’s Office, Spring 2013. 14. James C. Scott, Seeing... Cullen , “The MQ-9 Reaper Remotely Piloted Aircraft: Humans and Machines in Ac- tion” (PhD diss., Massachusetts Institute of Technology, 2011), 129, 216

  19. Yeni Redhouse Lugati; Ingilizce-Turkce (Revised Redhouse Dictionairy; English-Turkish).

    Science.gov (United States)

    United Church Board for World Ministries, Istanbul (Turkey). Near East Mission.

    The general plan of this dictionary, first prepared by Sir James Redhouse in 1861 and revised in 1950 and 1953, has been to include all words which appear in the Oxford Concise Dictionary and Webster's Collegiate Dictionary. In addition, a great number of idioms have been added; the volume now contains between 60,000 and 70,000 definitions.…

  20. The world in eighteen lessons: Christopher Williams

    NARCIS (Netherlands)

    Berrebi, S.

    2011-01-01

    Conceptual photographer Christopher Williams is a real artist's artist. Ever since he moved to Germany, his measured work, which both reveres and examines the art of photography, has more and more easily found its way into European art institutes, such as this spring at Museum Dhondt-Dhaenens in

  1. Analysis of Speech Fluency in Williams Syndrome

    Science.gov (United States)

    Rossi, Natalia Freitas; Sampaio, Adriana; Goncalves, Oscar F.; Giacheti, Celia Maria

    2011-01-01

    Williams syndrome (WS) is a neurodevelopmental genetic disorder, often referred as being characterized by dissociation between verbal and non-verbal abilities, although the number of studies disputing this proposal is emerging. Indeed, although they have been traditionally reported as displaying increased speech fluency, this topic has not been…

  2. Attribution of Negative Intention in Williams Syndrome

    Science.gov (United States)

    Godbee, Kali; Porter, Melanie A.

    2013-01-01

    People with Williams syndrome (WS) are said to have sociable and extremely trusting personalities, approaching strangers without hesitation. This study investigated whether people with WS are less likely than controls to attribute negative intent to others when interpreting a series of ambiguous pictures. This may, at least partially, explain…

  3. Petroleum possibilities of the James Bay Lowland area: Drilling in the James Bay Lowland

    Energy Technology Data Exchange (ETDEWEB)

    Martison, N W

    1954-12-31

    Interest in the possible occurrence of petroleum and natural gas in the James Bay lowland arises from the presence there of Palaeozoic sedimentary formations resembling those in south-western Ontario. The first part of this report reviews earlier geologic surveys conducted in the lowland and reports results of field work and drill core studies 1946-51. It describes the area`s topography, climate, stratigraphy and palaeontology (Ordovician to Lower Cretaceous, plus Pleistocene and recent glacial deposits), structural geology, and evidence of petroleum. Lists of fossils and correlations are included. The appendices include a list of fossil locations and drill logs. The second part details the drilling programs carried out in the lowland by the Ontario Dept. of Mines, including detailed logs, as well as drilling carried out by some other organisations.

  4. New approaches to improve a WCDMA SIR estimator by employing different post-processing stages

    Directory of Open Access Journals (Sweden)

    Amnart Chaichoet

    2008-09-01

    Full Text Available For effective control of transmission power in WCDMA mobile systems, a good estimate of signal-to-interference ratio (SIR is needed. Conventionally, an adaptive SIR estimator employs a moving average (MA filter (Yoon et al., 2002 to encounter fading channel distortion. However, the resulting estimate seems to have high estimation error due to fluctuation in the channel variation. In this paper, an additional post-processing stage is proposed to improve the estimation accuracy by reducing the variation of the estimate. Four variations of post-processing stages, namely 1 a moving average (MA postfilter,2 an exponential moving average (EMA post-filter, 3 an IIR post-filter and 4 least-mean-squared (LMS adaptive post-filter, are proposed and their optimal performance in terms of root-mean-square error (RMSE are then compared by simulation. The results show the best comparable performance when the MA and LMS post-filter are used. However, the MA post-filter requires a lookup table of filter order for optimal performance at different channel conditions, while the LMS post-filter can be used conveniently without a lookup table.

  5. William Barlow and the Determination of Atomic Arrangement in Crystals.

    Science.gov (United States)

    Mauskopf, Seymour H

    2015-04-01

    William Barlow (1845-1934) was an important if unconventional scientist, known for having developed the 'closest-packing' atomic models of crystal structure. He resumed an early nineteenth-century tradition of utilizing crystallographical and chemical data to determine atomic arrangements in crystals. This essay recounts Barlow's career and scientific activity in three parts: (a) His place in the tradition of determining atomic arrangement in context of this earlier tradition and of contemporaneous developments of crystallography and chemistry, (b) his unconventional career, and (c) the 'success' of his program to determine atomic arrangements in crystals and its influence on the work of William Lawrence Bragg.

  6. Design of power controller in CDMA system with power and SIR error minimization

    Institute of Scientific and Technical Information of China (English)

    Shulan KONG; Huanshui ZHANG; Zhaosheng ZHANG; Hongxia WANG

    2007-01-01

    In this paper, an uplink power control problem is considered for code division multiple access (CDMA) systems. A distributed algorithm is proposed based on linear quadratic optimal control theory. The proposed scheme minimizes the sum of the power and the error of signal-to-interference ratio (SIR). A power controller is designed by constructing an optimization problem of a stochastic linear quadratic type in Krein space and solving a Kalman filter problem.

  7. Persistent organic pollutants in soils and sediments from James Ross Island, Antarctica

    International Nuclear Information System (INIS)

    Klanova, Jana; Matykiewiczova, Nina; Macka, Zdenek; Prosek, Pavel; Laska, Kamil; Klan, Petr

    2008-01-01

    Soil and sediment samples from James Ross Island were analyzed for their PCB, OCP and PAH contents. Soil concentrations ranged between 0.51 and 1.82 ng g -1 for seven indicator PCB congeners, between 0.49 and 1.34 ng g -1 for HCH congeners, between 0.51 and 3.68 ng g -1 for the sum of p,p'-DDT, DDE, and DDD, and between 34.9 and 171 ng g -1 for the sum of 16 EPA PAHs. Sediment levels from 0.32 to 0.83 ng g -1 were found for PCBs, from 0.14 to 0.76 ng g -1 for HCHs, from 0.19 to 1.15 ng g -1 for DDTs, and from 1.4 to 205 ng g -1 for PAHs. A prevalence of low-mass PAHs, less chlorinated PCBs, and more volatile chemicals indicates that the long-range atmospheric transport from populated areas of Africa, South America, and Australia is the most probable contamination source for the solid matrices in James Ross Island. - A survey of soil, sediment and air contamination in James Ross Island, Antarctica serves as a baseline study for evaluation of an anthropogenic impact of the new research facility

  8. 77 FR 63308 - J. William Foley Incorporated v. United Illuminating Company; Notice of Complaint

    Science.gov (United States)

    2012-10-16

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL12-106-000] J. William Foley Incorporated v. United Illuminating Company; Notice of Complaint Take notice that on October 5...) and 825(e), J. William Foley Incorporated (Complainant) filed a formal complaint against United...

  9. Crystal clear the autobiographies of Sir Lawrence and Lady Bragg

    CERN Document Server

    Thomson, Patience

    2015-01-01

    The main body of this book contains the hitherto unpublished autobiographies of both William Lawrence Bragg, an innovative scientist who won the Nobel Prize for Physics in 1915, and his wife, Alice, a Mayor of Cambridge and National Chairman of Marriage Guidance. Their autobiographies give unusual insights into the lives and times of two distinguished people and the real personalities behind their public appearance.

  10. Keening Woman and Today: James Welch's Early Unpublished Novel

    Science.gov (United States)

    Orton, Thomas

    2006-01-01

    It was most likely in the spring of 1966 that the late American Indian novelist James Welch wrote his first novel, predating his first published fiction by eight years. The titleless, hand-corrected typescript, stored in his Missoula home for many years, is 114 pages long and unfinished. The book is playful and experimental the way warm-ups…

  11. Application of Choi—Williams Reduced Interference Time Frequency Distribution to Machinery Diagnostics

    Directory of Open Access Journals (Sweden)

    Howard A. Gaberson

    1995-01-01

    Full Text Available This article discusses time frequency analysis of machinery diagnostic vibration signals. The short time Fourier transform, the Wigner, and the Choi–Williams distributions are explained and illustrated with test cases. Examples of Choi—Williams analyses of machinery vibration signals are presented. The analyses detect discontinuities in the signals and their timing, amplitude and frequency modulation, and the presence of different components in a vibration signal.

  12. The Way of Saint James and the Xacobeo 2010 in the tourism websites of the Spanish autonomous communities

    Directory of Open Access Journals (Sweden)

    María-Dolores Fernández-Poyatos, Ph.D.

    2012-01-01

    Full Text Available This article analyses the tourism websites of Spanish autonomous communities crossed by the Way of Saint James. Considering that the Way of Saint James and the Xacobeo 2010 are important touristic opportunities for these autonomous regions, the main objective of this investigation is to evaluate the information about these touristic places in their tourism websites. The analysis focused on two aspects: firstly, establishing whether the autonomous communities have used the Way of Saint James and the Xacobeo 2010 to promote themselves, and secondly, evaluating the quality of the websites. The study included a literature review, definition of concepts and criteria to measure the quality of websites, and the analysis of the content and design of the selected tourism websites. The results show that the Galician website is the most complete in terms of information about the Way of Saint James and the Xacobeo 2010. The information about the Way of Saint James and the Xacobeo 2010 in the websites of the other communities is vague and differs from one website to another. Due to the touristic significance of the Xacobeo 2010 and the importance of Internet as a medium of communication, the research group plans to conduct a new analysis of the communities’ institutional websites in 2011.

  13. Nutritional support of the hospitalized patIent

    African Journals Online (AJOL)

    1983-04-16

    Apr 16, 1983 ... one ofthe earliest attempts known was that of Sir Christopher. \\\\hen, to whom 50 much ofthe architectural elegance of London can be attributed, being ..... O'Keefe SJO, Abraham R, EI-Zayadi A, Marshall W, O"'is M, Williams R. Increased plasma tyrosine concentrations in patients with cirrhosis and fulmi-.

  14. 75 FR 16520 - James A. Fitzpatrick Nuclear Power Plant; Exemption

    Science.gov (United States)

    2010-04-01

    ... Power Plant; Exemption 1.0 Background Entergy Nuclear Operations, Inc. (the licensee) is the holder of Facility Operating License No. DPR-59, which authorizes operation of the James A. FitzPatrick Nuclear Power... date for all operating nuclear power plants, but noted that the Commission's regulations provide...

  15. Astronaut James Lovell checks body temperature with oral temperature probe

    Science.gov (United States)

    1965-01-01

    Gemini 7 pilot Astronaut James A. Lovell Jr. has temperature check with oral temperature probe attached to his space suit during final preflight preparations for the Gemini 7 space mission. The temperature probe allows doctors to monitor astronauts body temperature at any time during the mission.

  16. Increased overall cortical connectivity with syndrome specific local decreases suggested by atypical sleep-EEG synchronization in Williams syndrome.

    Science.gov (United States)

    Gombos, Ferenc; Bódizs, Róbert; Kovács, Ilona

    2017-07-21

    Williams syndrome (7q11.23 microdeletion) is characterized by specific alterations in neurocognitive architecture and functioning, as well as disordered sleep. Here we analyze the region, sleep state and frequency-specific EEG synchronization of whole night sleep recordings of 21 Williams syndrome and 21 typically developing age- and gender-matched subjects by calculating weighted phase lag indexes. We found broadband increases in inter- and intrahemispheric neural connectivity for both NREM and REM sleep EEG of Williams syndrome subjects. These effects consisted of increased theta, high sigma, and beta/low gamma synchronization, whereas alpha synchronization was characterized by a peculiar Williams syndrome-specific decrease during NREM states (intra- and interhemispheric centro-temporal) and REM phases of sleep (occipital intra-area synchronization). We also found a decrease in short range, occipital connectivity of NREM sleep EEG theta activity. The striking increased overall synchronization of sleep EEG in Williams syndrome subjects is consistent with the recently reported increase in synaptic and dendritic density in stem-cell based Williams syndrome models, whereas decreased alpha and occipital connectivity might reflect and underpin the altered microarchitecture of primary visual cortex and disordered visuospatial functioning of Williams syndrome subjects.

  17. Notas no percurso: linguagem musical e Síndrome de Williams/Notes on the way: musical language and Williams Syndrome

    Directory of Open Access Journals (Sweden)

    Paulo Sérgio Souza Junior

    2009-12-01

    Full Text Available O presente artigo versa sobre uma síndrome em particular chamada Síndrome de Williams-Beuren. Esta síndrome possui uma relação específica com a música, relação esta que estará no fulcro de nossas preocupações durante as páginas que se seguem. Num primeiro momento faremos uma apresentação da síndrome e de suas singularidades; em seguida nos debruçaremos sobre a especificidade que aqui está em questão, ou seja, a relação da síndrome com o universo sonoro; por fim, traremos um caso com o qual tivemos contato envolvendo a educação musical em contexto da síndrome, e discutiremos a respeito dos elementos que esse contato nos trouxe para pensar essa curiosa e relevante relação entre arte-educação e o desenvolvimento neuropsicológico atípico. The present article is about a particular syndrome, called Williams-Beuren. This syndrome has a very specific relationship with music, which will be at the heart of our concerns over the following pages. Initially we will make a presentation of the syndrome and its singularities. Then we will focus on the uniqueness of the correlation between Williams-Beuren and the musical world. Finally, we will discuss a case which involves musical education in the context of this syndrome, and discuss about the elements, brought by that contact, that are useful to think about this curious and relevant relationship between art education and atypical neuropsychological development.

  18. 77 FR 58819 - Notice of Submission for OMB Review; Federal Student Aid; William D. Ford Federal Direct Loan...

    Science.gov (United States)

    2012-09-24

    ... DEPARTMENT OF EDUCATION Notice of Submission for OMB Review; Federal Student Aid; William D. Ford... William D. Ford Federal Direct Loan Program will use this form to request forbearance on their loans when... of Collection: William D. Ford Federal Direct Loan Program General Forbearance Request. OMB Control...

  19. 77 FR 29988 - Notice of Submission for OMB Review; Federal Student Aid; William D. Ford Federal Direct Loan...

    Science.gov (United States)

    2012-05-21

    ... DEPARTMENT OF EDUCATION Notice of Submission for OMB Review; Federal Student Aid; William D. Ford... borrowers in the William D. Ford Federal Direct Loan (Direct Loan) and Federal Family Education Loan (FFEL... of Collection: William D. Ford Federal Direct Loan Program Deferment Request Forms. OMB Control...

  20. Crystallization and preliminary X-ray diffraction studies of the putative haloalkane dehalogenase DppA from Plesiocystis pacifica SIR-I

    International Nuclear Information System (INIS)

    Bogdanović, Xenia; Hesseler, Martin; Palm, Gottfried J.; Bornscheuer, Uwe T.; Hinrichs, Winfried

    2010-01-01

    The crystallization and preliminary X-ray diffraction studies of DppA from P. pacifica SIR-I are reported. DppA from Plesiocystis pacifica SIR-I is a putative haloalkane dehalogenase (EC 3.8.1.5) and probably catalyzes the conversion of halogenated alkanes to the corresponding alcohols. The enzyme was expressed in Escherichia coli BL21 and purified to homogeneity by ammonium sulfate precipitation and reversed-phase and ion-exchange chromatography. The DppA protein was crystallized by the vapour-diffusion method and protein crystals suitable for data collection were obtained in the orthorhombic space group P2 1 2 1 2. The DppA crystal diffracted X-rays to 1.9 Å resolution using an in-house X-ray generator

  1. Engineers on the Twin Rivers: A History of the Nashville District Corps of Engineers United States Army

    Science.gov (United States)

    1978-01-01

    Kentucky, near the present site of Barkley Dam. The schooners Fanny and Maria and Con- cordia were built by James Winchester, William Cage, James Cage...Cumber- land Valley. Many farmers hoped to abandon the uncertain business of farm- ing and get rich by feeding the produc- tive worms. Acres were planted ...frequently attempt to capture the entire plant , careless of any damage inflicted on the lock masonry, lock gates, lever of sluices, &c." To curb this "in

  2. Clinical utility of an array comparative genomic hybridization analysis for Williams syndrome.

    Science.gov (United States)

    Yagihashi, Tatsuhiko; Torii, Chiharu; Takahashi, Reiko; Omori, Mikimasa; Kosaki, Rika; Yoshihashi, Hiroshi; Ihara, Masahiro; Minagawa-Kawai, Yasuyo; Yamamoto, Junichi; Takahashi, Takao; Kosaki, Kenjiro

    2014-11-01

    To reveal the relation between intellectual disability and the deleted intervals in Williams syndrome, we performed an array comparative genomic hybridization analysis and standardized developmental testing for 11 patients diagnosed as having Williams syndrome based on fluorescent in situ hybridization testing. One patient had a large 4.2-Mb deletion spanning distally beyond the common 1.5-Mb intervals observed in 10/11 patients. We formulated a linear equation describing the developmental age of the 10 patients with the common deletion; the developmental age of the patient with the 4.2-Mb deletion was significantly below the expectation (developmental age = 0.51 × chronological age). The large deletion may account for the severe intellectual disability; therefore, the use of array comparative genomic hybridization may provide practical information regarding individuals with Williams syndrome. © 2014 Japanese Teratology Society.

  3. Briti parim maja on Peckhami raamatukogu / Ingrid Lillemägi

    Index Scriptorium Estoniae

    Lillemägi, Ingrid

    2000-01-01

    2000. a. James Stirlingi auhinna said arhitektid William Alsop ja Jan Störmer (Peckhami raamatukogu), keskkondlikkuse auhinna sai büroo Chetwood & Associates (Sainsbury's supermarket), Stephen Lawrence'i auhinna büroo Softroom Architects (praamiootepaviljon). 1 ill

  4. Shepard Award Winners, Part 2: Dr. Tracie Williams

    Centers for Disease Control (CDC) Podcasts

    2009-07-29

    This podcast highlights the accomplishments of Dr. Tracie Williams, recipient of the prestigious 2009 CDC Charles C. Shepard Award.  Created: 7/29/2009 by Centers for Disease Control and Prevention (CDC).   Date Released: 7/29/2009.

  5. The contribution of CLIP2 haploinsufficiency to the clinical manifestations of the Williams-Beuren syndrome.

    Science.gov (United States)

    Vandeweyer, Geert; Van der Aa, Nathalie; Reyniers, Edwin; Kooy, R Frank

    2012-06-08

    Williams-Beuren syndrome is a rare contiguous gene syndrome, characterized by intellectual disability, facial dysmorphisms, connective-tissue abnormalities, cardiac defects, structural brain abnormalities, and transient infantile hypercalcemia. Genes lying telomeric to RFC2, including CLIP2, GTF2I and GTF2IRD1, are currently thought to be the most likely major contributors to the typical Williams syndrome cognitive profile, characterized by a better-than-expected auditory rote-memory ability, a relative sparing of language capabilities, and a severe visual-spatial constructive impairment. Atypical deletions in the region have helped to establish genotype-phenotype correlations. So far, however, hardly any deletions affecting only a single gene in the disease region have been described. We present here two healthy siblings with a pure, hemizygous deletion of CLIP2. A putative role in the cognitive and behavioral abnormalities seen in Williams-Beuren patients has been suggested for this gene on the basis of observations in a knock-out mouse model. The presented siblings did not show any of the clinical features associated with the syndrome. Cognitive testing showed an average IQ for both and no indication of the Williams syndrome cognitive profile. This shows that CLIP2 haploinsufficiency by itself does not lead to the physical or cognitive characteristics of the Williams-Beuren syndrome, nor does it lead to the Williams syndrome cognitive profile. Although contribution of CLIP2 to the phenotype cannot be excluded when it is deleted in combination with other genes, our results support the hypothesis that GTF2IRD1 and GTF2I are the main genes causing the cognitive defects associated with Williams-Beuren syndrome. Copyright © 2012 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  6. Brief Report: Developing Spatial Frequency Biases for Face Recognition in Autism and Williams Syndrome

    Science.gov (United States)

    Leonard, Hayley C.; Annaz, Dagmara; Karmiloff-Smith, Annette; Johnson, Mark H.

    2011-01-01

    The current study investigated whether contrasting face recognition abilities in autism and Williams syndrome could be explained by different spatial frequency biases over developmental time. Typically-developing children and groups with Williams syndrome and autism were asked to recognise faces in which low, middle and high spatial frequency…

  7. Denigrating Carl Rogers: William Coulson's Last Crusade.

    Science.gov (United States)

    Kirschenbaum, Howard

    1991-01-01

    Reviews William Coulson's assertions that Carl Rogers, Abraham Maslow, and he initiated the humanistic education field, that Rogers repudiated his philosophy late in life, and that they owe the nation's parents an apology. Argues that these charges are groundless and provides examples and quotations from Rogers' later writings to show how Rogers…

  8. Fears, Hyperacusis and Musicality in Williams Syndrome

    Science.gov (United States)

    Blomberg, Stefan; Rosander, Michael; Andersson, Gerhard

    2006-01-01

    The study investigated the prevalence of fear and hyperacusis and the possible connections between fear, hyperacusis and musicality in a Swedish sample of individuals with Williams syndrome (WS). The study included 38 individuals and a cross-sectional design, with no matched control group. Two persons, who knew the participant well, completed a…

  9. Executive Functions in Individuals with Williams Syndrome

    Science.gov (United States)

    Menghini, D.; Addona, F.; Costanzo, F.; Vicari, S.

    2010-01-01

    Background: The present study was aimed at investigating working memory (WM) and executive functions capacities in individuals with Williams syndrome (WS) as compared with mental-age matched typically developing (TD) children. Method: In order to serve the study goal, a sizeable battery of tasks tapping WM as well as attention, memory, planning,…

  10. Power and dignity: the social consequences of hydro-electric development for the James Bay Cree

    International Nuclear Information System (INIS)

    Niezen, R.

    1993-01-01

    The social impact that large-scale hydro-electric development has on the Cree of James Bay following the construction of the La Grande Complex was discussed. Many environmental changes were brought about by dam construction. The project, which also involved the first settlement (the James Bay and Northern Quebec Agreement) directed at extinguishing aboriginal title to land and natural resources in Canada, resulted in several relocations of Cree communities. In addition to compensation, the Agreement included a formal procedure for environmental and social impact assessment for development projects. However, there was little commitment, as a matter of corporate or government policy, to monitoring any of the social impacts. This paper is a preliminary response to an appeal for attention to be focused on the social consequences of hydro-electric development for the Cree in James Bay. Data from social service files indicate that the rapid centralization of the James Bay Cree into structured communities led to social instability in the villages, reflected by high frequencies in suicide, neglect of children, vandalism and drug and alcohol abuse. The material presented here is expected to serve as a warning that in further developing the far North of Quebec the pace of social change in Cree society will have to be slowed down to avoid social destruction of the native communities. 15 refs., 2 tabs

  11. Power and dignity: the social consequences of hydro-electric development for the James Bay Cree

    Energy Technology Data Exchange (ETDEWEB)

    Niezen, R [Harvard Univ., Boston, MA (United States)

    1993-11-01

    The social impact that large-scale hydro-electric development has on the Cree of James Bay following the construction of the La Grande Complex was discussed. Many environmental changes were brought about by dam construction. The project, which also involved the first settlement (the James Bay and Northern Quebec Agreement) directed at extinguishing aboriginal title to land and natural resources in Canada, resulted in several relocations of Cree communities. In addition to compensation, the Agreement included a formal procedure for environmental and social impact assessment for development projects. However, there was little commitment, as a matter of corporate or government policy, to monitoring any of the social impacts. This paper is a preliminary response to an appeal for attention to be focused on the social consequences of hydro-electric development for the Cree in James Bay. Data from social service files indicate that the rapid centralization of the James Bay Cree into structured communities led to social instability in the villages, reflected by high frequencies in suicide, neglect of children, vandalism and drug and alcohol abuse. The material presented here is expected to serve as a warning that in further developing the far North of Quebec the pace of social change in Cree society will have to be slowed down to avoid social destruction of the native communities. 15 refs., 2 tabs.

  12. Revolution and Exploration: the English Translations of Rousseau and Humboldt by Helen Maria Williams

    Directory of Open Access Journals (Sweden)

    Paula Yurss Lasanta

    2017-12-01

    Full Text Available British author Helen Maria Williams (1759-1827 was a well-known figure in the eighteenth century literary circles, whose work was praised by Elizabeth Montagu, Samuel Johnson, Dorothy and William Wordsworth, Mary Wollstonecraft, Hester Piozzi or Alexander von Humboldt.  In her early poems  Edwin and Eltruda (1782, An Ode to the Peace (1783 and Peru (1784, Williams starts to reveal her political tendencies by appealing to strong empathic feelings as a key to social and political transformation. As a result of her interest in politics, she travelled to France in 1790 and published her most acclaimed work Letters from France (1790. However, the rest of her production has received little critical attention by modern scholars, who have overlooked her involvement in translation. Williams’ only extant novel, Julia (1790 is in fact a creative translation of Rousseau’s Julie ou La Nouvelle Héloïse (1761, in which Williams includes poems that evidence her interest in revolutionary politics. Four years later, she translated Bernardin de Saint Pierre’s Paul et Virginie, while she was imprisoned in Paris. While translating novels was regarded as a respectable exercise for women writers, Williams challenges gender assumptions by translating Researches (1814 and the seven volumes of Personal Narrative (1814-1829, which had been produced by one of the most influential eighteenth century scientists, Alexander von Humboldt. This article interrogates how Williams makes use of translation to access areas of knowledge traditionally restricted to men, such as philosophy, politics and science. For this purpose, I will focus on her translations of the work of two leading intellectual figures of the eighteenth century,  Rousseau and Von Humboldt.

  13. WILLIAM STANLEY JEVONS: EL USO DE LAS PROBABILIDADES Y EL CÁLCULO

    Directory of Open Access Journals (Sweden)

    Jhon James Mora

    2000-01-01

    Full Text Available En el capítulo tercero de la TPE, Jevons recurre al uso de las probabilidades como un método alternativo para analizar el intercambio de las mercancías. Jevons, decide no continuar con el uso de las probabilidades en los capítulos siguientes; su teoría se bifurca imperando el uso del cálculo diferencial. La explicación de esta bifurcación radica en la existencia de dos métodos alternativos para explicar el análisis del intercambio: La teoría de las probabilidades y el cálculo diferencial. Usar el cálculo diferencial no significaba que fuese el método más eficiente, pues no sólo existieron errores al maximizar como muestra Westergaard (1874, sino también problemas metodológicos, como muestran Stigler (1956 y Blaug (1985. Por otro lado, el método de las probabilidades habría significado para el análisis del intercambio, un problema de valores esperados y un camino totalmente diferente para la revolución marginalista. WILLIAM STANLEY JEVONS: EL USO DE LAS PROBABILIDADES Y EL CÁLCULO JOHN JAMES MORA R.1 Economista Universidad del Valle. Maestría en Economía Ambiental Universidad Autónoma de Madrid. Jefe del Departamento de Economía de la Universidad Icesi e-mail:jjmora@icesi.edu.co 1. Este ensayo comenzó a escribirse hace casi cinco años, cuando era asistente de investigación del profesor Boris Salazar en la Universidad del Valle. Muchos eventos impidieron culminar esta “deuda intelectual” que tenía con Boris, quien nunca ha reparado en brindarme su desinteresada crítica y, de quien siempre estaré en deuda.

  14. Läbi legendide William Shakespeare'i poole / Maris Peters

    Index Scriptorium Estoniae

    Peters, Maris

    2010-01-01

    Tutvustus: Wells, Stanley. Kas on tõsi, et Shakespeare ...? / tõlkinud Maris Peters. Tallinn : Argo, 2010. Raamat William Shakespeare kohta käivatest legendidest, kuuldustest ja teooriatest ning tema teoste autorsusest

  15. William and Caroline Herschel pioneers in late 18th-century astronomy

    CERN Document Server

    Hoskin, Michael

    2013-01-01

    This beautifully structured book presents the essentials of William and Caroline Herschel's pioneering achievements in late 18th-century astronomy. Michael Hoskin shows that William Herschel was the first observational cosmologist and one of the first observers to attack the sidereal universe beyond the solar system:Herschel built instruments far better than any being used at the royal observatory. Aided by his sister Caroline, he commenced a great systematic survey that led to his discovery of Uranus in 1781.Unlike observers before him, whose telescopes did not reveal them as astronomical obj

  16. Kes on kes ehk Tulgu uus taevas / Ervin Õunapuu

    Index Scriptorium Estoniae

    Õunapuu, Ervin, 1956-

    2002-01-01

    Tuntud tegijad, kes on oma sõnul ateistid, agnostikud või umbuskliku suhtumisega ristiusu kirikusse: William Seward Burroughs, Vincent Van Gogh, Oscar Niemeyer, Sven Alur Reinans, Sir Joshua Reynolds, Diego Rivera, Neil Rogers, John Ruskin, Matt Wagner, Frank Lloyd Wright, Ervin Õunapuu jne. Ilmunud ka kogumikus "Öövöö", lk.109-124

  17. Groundbreaking Investigator of Creativity: An Interview with James C. Kaufman

    Science.gov (United States)

    Henshon, Suzanna E.

    2010-01-01

    This article presents an interview with James C. Kaufman, an associate professor of psychology at the California State University at San Bernardino, where he directs the Learning Research Institute. Kaufman received his PhD in cognitive psychology from Yale University in 2001. Dr. Kaufman's research broadly focuses on nurturing and encouraging…

  18. 75 FR 13323 - James A. Fitzpatrick Nuclear Power Plant; Exemption

    Science.gov (United States)

    2010-03-19

    ... Power Plant; Exemption 1.0 Background Entergy Nuclear Operations, Inc. (the licensee) is the holder of... nuclear power plants that were licensed before January 1, 1979, satisfy the requirements of 10 CFR Part 50...), as supplemented by letter dated March 30, 2009, ``James A. FitzPatrick Nuclear Power Plant-Response...

  19. Thermal vacuum test of space equipment: tests of SIR-2 instrument Chandrayaan-1 mission

    Science.gov (United States)

    Sitek, P.

    2008-11-01

    We describe the reasons of proceeding Thermal-Vacuum tests for space electronic. We will answer on following questions: why teams are doing TV tests, what kind of phases should be simulated, which situations are the most critical during TV tests, what kind of results should be expected, which errors can be detect. As an example, will be shown TV-test of SIR-2 instrument for Chandrayaan-1 moon mission.

  20. Herbert Hoover and William Shakespeare: Two Writers on Ethics.

    Science.gov (United States)

    Somers, Margaret L.

    1979-01-01

    Outlines the ways in which Herbert Hoover and William Shakespeare wrote about professional ethics (for engineers and kings, respectively) using the writing techniques of concreteness, audience awareness, and development by induction. (TJ)

  1. James Wertsi ja SaxEsti ühiskontsert. "Valge gospel" asub taas tuurile

    Index Scriptorium Estoniae

    2007-01-01

    Ameerika laulja ja kitarristi James Wertsi ning saksofonikvarteti SaxEst kontserdituurist Eestis algusega 1. dets. Haljala rahvamajast. Kontserdituurist "Valge gospel" alates 11. dets. kuues Eestimaa kirikus (viimane kontsert 20. dets. Tallinna Linnahallis)

  2. Myšlení pozdního Wittgensteina a gramatika náboženského diskursu

    Directory of Open Access Journals (Sweden)

    Jan Regner

    2014-10-01

    Full Text Available The aim of the present paper is to find a way of the theological method after Ludwig Wittgenstein’s remarks, especially in his Philosophical Investigations. As he maintains, language and human behaviour is connected, and so we cannot judge religious discourse without observing other nonverbal phenomena. We focused on works and authors who influenced Wittgenstein’s thoughts such as William James and James G. Frazer; and we briefly introduced to Wittgenstein’s argumentation against scientism. Hlavním cílem tohoto článku je najít podobu teologické metody, která by vzala v potaz pozdní myšlení Ludwiga Wittgensteina, zejména jeho Filosofická zkoumání. Rakouský autor je přesvědčen, že jazyk je úzce spojen s lidským jednáním, a proto není možné posuzovat náboženský diskurs, aniž bychom bedlivě pozorovali nonverbální projevy, které tento diskurs provázejí. Zaměřili jsme se na díla autorů, kteří ovlivnili Wittgensteinovo myšlení, jako byl William James nebo James G. Frazer, a představili jsme také Wittgensteinovu argumentaci proti scientismu.

  3. 78 FR 45515 - Agency Information Collection Activities; Comment Request; William D. Ford Federal Direct Loan...

    Science.gov (United States)

    2013-07-29

    ... DEPARTMENT OF EDUCATION [Docket No.: ED-2013-ICCD-0099] Agency Information Collection Activities; Comment Request; William D. Ford Federal Direct Loan Program Repayment Plan Selection Form AGENCY... notice will be considered public records. Title of Collection: William D. Ford Federal Direct Loan...

  4. Psycholinguistic Abilities of Children with Williams Syndrome

    Science.gov (United States)

    Rossi, Natalia F.; Heinze, Elena Garayzabal; Giacheti, Celia M.; Goncalves, Oscar F.; Sampaio, Adriana

    2012-01-01

    The objective of this study was to investigate the psycholinguistic abilities of children with Williams syndrome (WS) and typically developing children using the Illinois Test of Psycholinguistic Abilities (ITPA). Performance on the ITPA was analysed in a group with WS (N=20, mean age=8.5 years, SD=1.62) and two typically developing groups,…

  5. 7 CFR 1412.47 - Planting flexibility.

    Science.gov (United States)

    2010-01-01

    ..., Imperial, Kern, Kings, Madera, Merced, Riverside, Sacramento, San Benito, San Joaquin, Santa Clara..., Henrico, Henry, Highland, Isle of Wight, James City, King and Queen, King George, King William, Lancaster..., persimmon, persian melon, pimentos, pineapple, pistachios, plantain, plumcots, plums, pomegranates, potatoes...

  6. 77 FR 2521 - Integrated System Power Rates

    Science.gov (United States)

    2012-01-18

    .... James K. McDonald, Administrator, Southwestern Power Administration, Department of Energy, Williams Center Tower I, One West Third Street, Tulsa, Oklahoma 74103, (918) 595-6690, jim.mcdonald@swpa.gov... Commission. Available: In the marketing area of Southwestern Power Administration (Southwestern), described...

  7. The Need to Re-Conceptualize African 'Traditional' Religion

    African Journals Online (AJOL)

    First Lady

    definitions of religion, point out the areas of misconception about African religion ... concrete deity or not‖ by William James (1902) opens up the idea of religion .... a belief which is also very central in the Judeo-Christian faith, especially in.

  8. London home for Crick archive.

    Science.gov (United States)

    Williams, Nigel

    2002-01-08

    Unprecedented access to the archives of Francis Crick, just before the 50th anniversary next year of his famous paper co-authored with James Watson on the proposed double helix structure of DNA, looks set to go ahead. Nigel Williams reports.

  9. 1 BEYOND BASIC EDUCATION: TOWARDS A PRAGMATARIAN ...

    African Journals Online (AJOL)

    Ike Odimegwu

    This implies that the human person is morally empowered and therefore .... of Right, whether any one on buying goods for his own business, realises a profit ... issue of right is out of order. Furthermore .... As William James explains, “we think.

  10. Arizonasesse kunsti nautima

    Index Scriptorium Estoniae

    1999-01-01

    Arizona osariigi Phoenixi osa Scottsdale uus Kaasaegse Kunsti Muuseum on kujundatud endisesse kinohoonesse. Efektseimad muutused tehti ehitise välispinnal. Hoone on kaetud hõbedaste galvaniseeritud metallist paneelidega. Lõunaküljel skulptuurjas klaasosa (kunstnik James Fraser). Arhitekt William P. Bruder

  11. 78 FR 52169 - Agency Information Collection Activities; Comment Request; William D. Ford Federal Direct Loan...

    Science.gov (United States)

    2013-08-22

    ... DEPARTMENT OF EDUCATION [Docket No. ED-2013-ICCD-0109] Agency Information Collection Activities; Comment Request; William D. Ford Federal Direct Loan (Direct Loan) Program Federal Direct PLUS Loan Master... to this notice will be considered public records. Title of Collection: William D. Ford Federal Direct...

  12. Williams syndrome deletions and duplications: Genetic windows to understanding anxiety, sociality, autism, and schizophrenia.

    Science.gov (United States)

    Crespi, Bernard J; Procyshyn, Tanya L

    2017-08-01

    We describe and evaluate an integrative hypothesis for helping to explain the major neurocognitive features of individuals with Williams syndrome region deletions and duplications. First, we demonstrate how the cognitive differences between Williams syndrome individuals, individuals with duplications of this region, and healthy individuals parallel the differences between individuals subject to effects of increased or decreased oxytocin. Second, we synthesize evidence showing that variation in expression of the gene GTF2I (General Transcription Factor II-I) underlies the primary social phenotypes of Williams syndrome and that common genetic variation in GTF2I mediates oxytocin reactivity, and its correlates, in healthy populations. Third, we describe findings relevant to the hypothesis that the GTF2I gene is subject to parent of origin effects whose behavioral expression fits with predictions from the kinship theory of genomic imprinting. Fourth, we describe how Williams syndrome can be considered, in part, as an autistic syndrome of Lorna Wing's 'active-but-odd' autism subtype, in contrast to associations of duplications with both schizophrenia and autism. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Williams syndrome and mature B-Leukemia: A random association?

    Science.gov (United States)

    Decimi, Valentina; Fazio, Grazia; Dell'Acqua, Fabiola; Maitz, Silvia; Galbiati, Marta; Rizzari, Carmelo; Biondi, Andrea; Cazzaniga, Giovanni; Selicorni, Angelo

    2016-12-01

    Williams syndrome (WBS) is a rare neurodevelopmental disorder with specific phenotypic characteristics and cardiac abnormalities, but is not considered as a cancer predisposing condition. However, in rare cases, malignancies have been described in patients with WBS, with hematologic cancer (mainly Burkitt Lymphoma and Acute Lymphoblastic Leukemia) as the most represented. We report here the case of a boy with WS and B-NHL. This is the unique case within the large cohort of patients (n = 117) followed in our institution for long time (mean clinical follow-up, 13 years). We herewith propose that the BCL7B gene, located in the chromosomal region commonly deleted in Williams syndrome, could potentially have a role in this particular association. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  14. Ischemic Stroke in Williams-Beuren Syndrome: A Case Report

    Directory of Open Access Journals (Sweden)

    Wei-Der Lee

    2009-04-01

    Full Text Available A 15-year-old girl was admitted because of an acute onset of facial palsy and right hemiparesis. The patient had a history of moderate mental retardation and developmental delay. On admission, her vital signs were stable, except for high blood pressure. Magnetic resonance imaging demonstrated an infarct involving the left internal capsule and putamen. Because of the patient's young age, an extensive stroke survey was performed. Williams-Beuren syndrome was finally confirmed by fluorescent in situ hybridization. Compared with the previously reported cases, no evidence of cerebral arterial stenosis or cardiac abnormalities was found by noninvasive imaging techniques. Because Williams-Beuren syndrome is a complex, multiple congenital anomaly syndrome with prominent cardiovascular features, regular assessment and antihypertensive treatment are necessary to minimize the lifelong cardiovascular risk in patients with this syndrome.

  15. Sawtooth events and O+ in the plasma sheet and boundary layer: CME- and SIR-driven events

    Science.gov (United States)

    Lund, E. J.; Nowrouzi, N.; Kistler, L. M.; Cai, X.; Liao, J.

    2017-12-01

    The role of ionospheric ions in sawtooth events is an open question. Simulations[1,2,3] suggest that O+ from the ionosphere produces a feedback mechanism for driving sawtooth events. However, observational evidence[4,5] suggest that the presence of O+ in the plasma sheet is neither necessary nor sufficient. In this study we investigate whether the solar wind driver of the geomagnetic storm has an effect on the result. Building on an earlier study[4] that used events for which Cluster data is available in the plasma sheet and boundary layer, we perform a superposed epoch analysis for coronal mass ejection (CME) driven storms and streaming interaction region (SIR) driven storms separately, to investigate the hypothesis that ionospheric O+ is an important contributor for CME-driven storms but not SIR-driven storms[2]. [1]O. J. Brambles et al. (2011), Science 332, 1183.[2]O. J. Brambles et al. (2013), JGR 118, 6026.[3]R. H. Varney et al. (2016), JGR 121, 9688.[4]J. Liao et al. (2014), JGR 119, 1572.[5]E. J. Lund et al. (2017), JGR, submitted.

  16. Dynamical Analysis of SIR Epidemic Models with Distributed Delay

    Directory of Open Access Journals (Sweden)

    Wencai Zhao

    2013-01-01

    Full Text Available SIR epidemic models with distributed delay are proposed. Firstly, the dynamical behaviors of the model without vaccination are studied. Using the Jacobian matrix, the stability of the equilibrium points of the system without vaccination is analyzed. The basic reproduction number R is got. In order to study the important role of vaccination to prevent diseases, the model with distributed delay under impulsive vaccination is formulated. And the sufficient conditions of globally asymptotic stability of “infection-free” periodic solution and the permanence of the model are obtained by using Floquet’s theorem, small-amplitude perturbation skills, and comparison theorem. Lastly, numerical simulation is presented to illustrate our main conclusions that vaccination has significant effects on the dynamical behaviors of the model. The results can provide effective tactic basis for the practical infectious disease prevention.

  17. "Attacking the Citadel": James Moncreiff's Proposals to Reform Scottish Education, 1851-69.

    Science.gov (United States)

    Bain, Wilson H.

    1978-01-01

    A review of the parliamentary actions of Lord Advocate James Moncreiff to create a fully national Scottish educational system against the opposition by church groups reluctant to lose control over parish schools and schoolmasters. (SJL)

  18. Experiences of Bullying for Individuals with Williams Syndrome

    Science.gov (United States)

    Fisher, Marisa H.; Lough, Emma; Griffin, Megan M.; Lane, Laurel A.

    2017-01-01

    Background: Individuals with intellectual disability experience high rates of bullying, but it is not known how people with specific syndromes, such as Williams syndrome (WS), experience and respond to bullying. Given their behavioral profile, including hypersociability and heightened anxiety, and their risk for experiencing other forms of…

  19. Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine.

    Science.gov (United States)

    McILwain, R Britt; Timpa, Joseph G; Kurundkar, Ashish R; Holt, David W; Kelly, David R; Hartman, Yolanda E; Neel, Mary Lauren; Karnatak, Rajendra K; Schelonka, Robert L; Anantharamaiah, G M; Killingsworth, Cheryl R; Maheshwari, Akhil

    2010-01-01

    Extracorporeal membrane oxygenation (ECMO) is a life-saving support system used in neonates and young children with severe cardiorespiratory failure. Although ECMO has reduced mortality in these critically ill patients, almost all patients treated with ECMO develop a systemic inflammatory response syndrome (SIRS) characterized by a 'cytokine storm', leukocyte activation, and multisystem organ dysfunction. We used a neonatal porcine model of ECMO to investigate whether rising plasma concentrations of inflammatory cytokines during ECMO reflect de novo synthesis of these mediators in inflamed tissues, and therefore, can be used to assess the severity of ECMO-related SIRS. Previously healthy piglets (3-week-old) were subjected to venoarterial ECMO for up to 8 h. SIRS was assessed by histopathological analysis, measurement of neutrophil activation (flow cytometry), plasma cytokine concentrations (enzyme immunoassays), and tissue expression of inflammatory genes (PCR/western blots). Mast cell degranulation was investigated by measurement of plasma tryptase activity. Porcine neonatal ECMO was associated with systemic inflammatory changes similar to those seen in human neonates. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) concentrations rose rapidly during the first 2 h of ECMO, faster than the tissue expression of these cytokines. ECMO was associated with increased plasma mast cell tryptase activity, indicating that increased plasma concentrations of inflammatory cytokines during ECMO may result from mast cell degranulation and associated release of preformed cytokines stored in mast cells. TNF-alpha and IL-8 concentrations rose faster in plasma than in the peripheral tissues during ECMO, indicating that rising plasma levels of these cytokines immediately after the initiation of ECMO may not reflect increasing tissue synthesis of these cytokines. Mobilization of preformed cellular stores of inflammatory cytokines such as in mucosal mast cells may have

  20. Late-Eighteenth-Century Precipitation Reconstructions from James Madison's Montpelier Plantation.

    Science.gov (United States)

    Druckenbrod, Daniel L.; Mann, Michael E.; Stahle, David W.; Cleaveland, Malcolm K.; Therrell, Matthew D.; Shugart, Herman H.

    2003-01-01

    This study presents two independent reconstructions of precipitation from James Madison's Montpelier plantation at the end of the eighteenth century. The first is transcribed directly from meteorological diaries recorded by the Madison family for 17 years and reflects the scientific interests of James Madison and Thomas Jefferson. In his most active period as a scientist, Madison assisted Jefferson by observing the climate and fauna in Virginia to counter the contemporary scientific view that the humid, cold climate of the New World decreased the size and number of its species. The second reconstruction is generated using tree rings from a forest in the Montpelier plantation and connects Madison's era to the modern instrumental precipitation record. These trees provide a significant reconstruction of both early summer and prior fall precipitation. Comparison of the dendroclimatic and diary reconstructions suggests a delay in the seasonality of precipitation from Madison's era to the mid-twentieth century. Furthermore, the dendroclimatic reconstructions of early summer and prior fall precipitation appear to track this shift in seasonality.