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Sample records for sir walter gilbey

  1. An Overview of Justice in Sir Walter Scott Waverley Novels: The Heart of Mid-Lothian

    Directory of Open Access Journals (Sweden)

    Enrique García Díaz

    2014-12-01

    Full Text Available Although Sir Walter Scott is a well-known writer most of his readers know that he became an advocate in 1792, when he was admitted to the bar. Since then Scott and other advocates walked the floor at Parliament House (home of the Faculty of Advocates and the Court of Session waiting to be hired. Scott’s own experiences as a fledgling advocate are echoed in those of Alain Fairford in his novel Redgauntlet (Scott 1824, which provides a vivid picture of Parliament House in the eighteenth century. During his life, Scott combined extensive writing and editing issues with his daily work as Clerk of Session and Sheriff-Depute of Selkirkshire. Walter Scott was not unaware of Justice and Law and The Heart of Mid-Lothian is the novel in which he introduces to the reader the Scottish Legal System during the eighteenth century. However, there are few more examples that I will explain. Aunque Sir Walter Scott es un conocido escritor, la mayoría de sus lectores saben que en 1792 se hizo abogado, cuando fue admitido en el colegio de abogados. Desde entonces Scott y otros abogados rondaron el Parlamento con la esperanza de ser contratados. Las propias experiencias de Scott como un abogado novel se reflejan en las de Alain Fairford en su novela Redgauntlet (Scott 1824, lo que ofrece una vívida imagen del Parlamento (sede de la facultad de Derecho y Tribunal Supremo en el siglo XVIII. Durante su vida, Scott compaginó una profusa actividad como escritor y editor con su trabajo diario como juez en Selkirk. Walter Scott conocía la justicia y el derecho y El corazón de Mid-Lothian es la novela en la presenta al lector el régimen jurídico de Escocia durante el siglo XVIII. Sin embargo, se explicarán algunos otros ejemplos. DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=2543538

  2. Walter Benjamins Berlin

    DEFF Research Database (Denmark)

    Walter Benjamin (1892-1940). Tolkning af alle 33 kapitler i Benjamins bybarndomserindringer fra Berlin i begyndelsen af det 20. århundrede.......Walter Benjamin (1892-1940). Tolkning af alle 33 kapitler i Benjamins bybarndomserindringer fra Berlin i begyndelsen af det 20. århundrede....

  3. Kodu kaitseks / Hannes Walter

    Index Scriptorium Estoniae

    Walter, Hannes, 1952-2004

    2012-01-01

    Kõne Eesti Muinsuskaitse Seltsi ja Eesti Akadeemilise Sõjaajaloo Seltsi korraldatud aktusel "Kodu kaitseks!" Tallinna Linnahallis 14. detsembril 1988. a. Vabadussõjast, selle tähendusest õppetundidest. Poleemika: Väitlus / Margus Laidre, Tõnu Tannberg, Hannes Walter, samas, lk. 332-338

  4. Hess, Prof. Walter Rudolf

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1966 Honorary. Hess, Prof. Walter Rudolf Nobel Laureate (Medicine) - 1949. Date of birth: 17 March 1881. Date of death: 12 August 1973. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting ...

  5. Haworth, Prof. Walter Norman

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1948 Honorary. Haworth, Prof. Walter Norman Nobel Laureate (Chemistry) - 1937. Date of birth: 19 March 1883. Date of death: 19 March 1950. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  6. Walter Ouro Alves

    Directory of Open Access Journals (Sweden)

    Revista Chasqui

    2015-01-01

    Full Text Available CIESPAL y la revista Chasqui, órgano de difusión de este Centro, unen su pesar al de la familia del compañero, amigo y maestro Walter Ouro Alves. Al rendir un homenaje de admiración y gratitud por su honesta y prolífica labor, C1ESPAL recomienda su nombre como impulsor de la democratización de las comunicaciones en América Latina.

  7. Walter Scandale honoured

    CERN Multimedia

    2009-01-01

    On 9 December 2008, Walter Scandale, a member of the EN Department, received the decoration of Knight of the Order of Merit of the Italian Republic, one of Italy’s highest decorations. He was awarded the medal by the Consul-General of Italy in Geneva on behalf of the President of the Italian Republic in recognition of his services to Italy in the field of science.

  8. Walter Greiner: In Memoriam

    Science.gov (United States)

    Zen Vasconcellos, César; Coelho, Helio T.; Hess, Peter Otto

    Walter Greiner (29 October 1935 - 6 October 2016) was a German theoretical physicist. His scientific research interests include the thematic areas of atomic physics, heavy ion physics, nuclear physics, elementary particle physics (particularly quantum electrodynamics and quantum chromodynamics). He is most known in Germany for his series of books in theoretical physics, but he is also well known around the world. Greiner was born on October 29, 1935, in Neuenbau, Sonnenberg, Germany. He studied physics at the University of Frankfurt (Goethe University in Frankfurt Am Main), receiving in this institution a BSci in physics and a Master’s degree in 1960 with a thesis on plasma-reactors, and a PhD in 1961 at the University of Freiburg under Hans Marshal, with a thesis on the nuclear polarization in μ-mesic atoms. During the period of 1962 to 1964 he was assistant professor at the University of Maryland, followed by a position as research associate at the University of Freiburg, in 1964. Starting in 1965, he became a full professor at the Institute for Theoretical Physics at Goethe University until 2003. Greiner has been a visiting professor to many universities and laboratories, including Florida State University, the University of Virginia, the University of California, the University of Melbourne, Vanderbilt University, Yale University, Oak Ridge National Laboratory and Los Alamos National Laboratory. In 2003, with Wolf Singer, he was the founding Director of the Frankfurt Institute for Advanced Studies (FIAS), and gave lectures and seminars in elementary particle physics. He died on October 6, 2016 at the age of 80. Walter Greiner was an excellent teacher, researcher, friend. And he was a great supporter of the series of events known by the acronyms IWARA - International Workshop on Astronomy and Relativistic Astrophysics, STARS - Caribbean Symposium on Cosmology, Gravitation, Nuclear and Astroparticle Physics, and SMFNS - International Symposium on Strong

  9. Vae Victis : Esimene juhtum : Walter Reder / Hannes Walter

    Index Scriptorium Estoniae

    Walter, Hannes, 1952-2004

    2004-01-01

    Teises maailmasõjas Saksamaa poolel võidelnud austerlasest Walter Rederist, kes mõisteti 1951. aastal Bolognas kommunistide korraldatud nn Stalini Venemaa stiilis kohtulavastuse tulemusena süüdi sõjaroimarina

  10. Mälestusi Walter Masingust

    Index Scriptorium Estoniae

    2006-01-01

    Erich Asumäe, Ahto Tihkani, Aivi Rossi, Aigar Saliste, Joann Lillemägi, Henno Viili meenutusi professor Walter Masingust, kes aastatel 1956-1959 oli EOQC-i (Euroopa Kvaliteedikontrolli organisatsioon) president

  11. Sir John Meurig Thomas.

    Science.gov (United States)

    Thomas, John Meurig

    2013-10-11

    "My greatest achievement has been to combine being a teacher, a researcher, and a popularizer of science for over 50 years. My worst nightmare is to find myself dumbstruck when I am about to give a lecture …︁" This and more about Sir John Meurig Thomas can be found on page 10938. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. A Propaedeutic to Walter Benjamin

    Science.gov (United States)

    Socher, David

    2009-01-01

    The Emerson College Web site on Walter Benjamin's essay "The Work of Art in an Age of Mechanical Reproduction" nicely animates some ideas of the essay. One such idea is the following: "To an ever greater degree the work of art reproduced becomes the work of art designed for reproducibility." When Benjamin wrote this essay and this maxim, Norman…

  13. Pergeseran Konsep Berarsitektur Walter Gropius

    OpenAIRE

    Rahmanina, Nur

    2009-01-01

    Tulisan ini akan membahas mengenai pengaruh professional environment terhadap arsitek dankonsepnya, sebagai objek pengkajian adalah Walter Gropius, seorang arsitek yang dikenal mengalamibeberapa kali pergeseran konsep dalam berarsitektur yang terjadi tidak dalam waktu yang lama.Pergeseran konsep berarsitektur Grapius dikaji untuk memperoleh gambaran penyebab terjadinyapergeseran tersebut dan adakah kemungkinan hal tersebut terjadi karena pengaruh unsur‐unsur di dalam professional environment.

  14. Whither Sir William?

    Directory of Open Access Journals (Sweden)

    Stephen J. Greenberg, MSLS, PhD

    2017-04-01

    Full Text Available There are times when something is simply so familiar that we can no longer see it at all. It can be a story, or a concept, or even a flesh-and-blood person. Familiarity breeds not only contempt, but a kind of invisibility as well. For too many of us, such is the case with Sir William Osler. In his time (1849–1919, many considered him to be one of the greatest practitioners, teachers, and writers ever in the field of medicine. He was instrumental in the founding of the Medical Library Association (MLA and was elected its second president.

  15. Sir Isaac Newton

    Directory of Open Access Journals (Sweden)

    E. A. Venter

    1964-03-01

    Full Text Available Die geweldige oplewing van die Christelike wetenskaps- gedagte in ons geeslose tyd, is ongetwyfeld ’n haas onverklaar- bare verskynsel. Dwarsdeur die eeue het Christene ook wetenskap beoefen saam met ongelowiges, maar dit was eers in ons leeftyd dat die principia van die Christelike religie ook vrugbaar gemaak is vir die wetenskapsbeoefening. In hierdie verband sal die name van Dooyeweerd, Vollenhoven, Stoker e.a. steeds met eer vermeld word. Natuurlik het belydende Christene ook voorheen wel deeglik saamgewerk aan die gebou van die wetenskap. Die intieme verband tussen religie, wysbegeerte en wetenskaps­ beoefening is toe egter nog nie suiwer ingesien nie. Uit hier­ die tydperk dateer die arbeid van sir Isaac Newton.

  16. Walter Pater and the Language of Sculpture

    DEFF Research Database (Denmark)

    Østermark-Johansen, Lene

    Walter Pater and the Language of Sculpture is the first monograph to discuss the Victorian critic Walter Pater's attitude to sculpture. It brings together Pater's aesthetic theories with his theories on language and writing, to demonstrate how his ideas of the visual and written language...... the idea of rivalry (paragone) more broadly, examining Pater's concern with positioning himself as an art critic in the late Victorian art world. Situating Pater within centuries of European aesthetic theories as never before done, Walter Pater and the Language of Sculpture throws new light...

  17. Summary of Steve Jobs, Walter Isaacson

    CERN Document Server

    Reader, Capitol

    2013-01-01

    This ebook consists of a summary of the ideas, viewpoints and facts presented by Walter Isaacson in his book "Steve Jobs". This summary offers a concise overview of the entire book in less than 30 minutes reading time. However this work does not replace in any case Walter Isaacson's book.Isaacson reveals the story of Steve Jobs career, which is a tale filled with lessons about innovation, character, leadership and being true to one's own values.

  18. El enigma de Walter Benjamin

    Directory of Open Access Journals (Sweden)

    Javier Sigüenza

    2015-06-01

    Full Text Available El siguiente ensayo inicia reconstruyendo el relato de los últimos días de la vida de Walter Benjamin, en el contexto histórico de la Segunda Guerra Mundial, y la existencia de un misterioso manuscrito perdido en su frustrada huida por la frontera franco-española en 1940; en la segunda parte se intenta descifrar la enigmática fisionomía del pensador berlinés, cuya perspectiva múltiple, tanto en lo teórico como en lo político, lo convierten en un autor incomprendido, pero tremendamente fascinante; en la tercera parte se explora uno de sus textos más herméticos, conocido como las tesis Sobre el concepto de historia, con la intención de poner de manifiesto el carácter crítico de su discurso, como clave para comprender los enigmas del mundo moderno y su necesaria transformación revolucionaria.

  19. Sir Karl Popper and Education

    Science.gov (United States)

    McNamara, D. R.

    1978-01-01

    Sir Karl Popper is one of England's most distinguished contemporary philosophers and it is surprising that his thought has not permeated and informed educational discussion. This paper suggests that educationists have much to learn from Karl Popper's writings and explores ways in which his ideas can illuminate and advance discussion about…

  20. Geim, Prof. Sir Andre Konstantin

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...

  1. Thomas, Prof. Sir John Meurig

    Indian Academy of Sciences (India)

    Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage ... Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more.

  2. King, Prof. Sir David Anthony

    Indian Academy of Sciences (India)

    Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.

  3. Walter van der Cruijsen / Walter van der Cruijsen ; interv. Tilman Baumgärtel

    Index Scriptorium Estoniae

    Cruijsen, Walter van der

    2006-01-01

    1997. a. Berliinis tehtud intervjuu hollandi maali, võrgu- ja installatsioonikunstniku Walter van der Cruijseniga (sünd. 1958), kes kuulub Euroopa ühe edukama 1990-ndatel loodud võrguprojekti De Digitale Stad Amsterdam loojate hulka

  4. Children, Redemption and Remembrance in Walter Benjamin

    Science.gov (United States)

    Jessop, Sharon

    2013-01-01

    Walter Benjamin wrote extensively on children and childhood, though this aspect of his work has hitherto received scant attention despite continuing and growing interest in his thought. This article makes explicit the connection between his acute observations of childhood and his distinctive messianic philosophy. The twin aspects of redemption in…

  5. Walter Frank Raphael Weldon (1860–1906)

    Indian Academy of Sciences (India)

    the second child of Walter Weldon and Anne Cotton. He had ... dergo a regular school education till the age of thirteen, although he was informally taught by .... nent of the importance of discontinuous variations in evolution, and an opponent of ...

  6. Federal president Walter Scheel on nuclear energy

    International Nuclear Information System (INIS)

    Scheel, W.

    1977-01-01

    On the occasion of the award of the Theodor-Heuss-Prize in Munich on February 11th, 1977, the President of the Federal Republic Walter Scheel commented on the citizens' contribution to basic values. In doing this the President also spoke about the peaceful utilization of nuclear energy and stated finally: 'It is wrong to see only the risk of nuclear energy, to discuss only this. We must realize that in many parts of our society we have ushered in developments which involve similar, partly even bigger danger and risk than nuclear energy. And we must be prepared to face those risks everywhere.' (orig./HP) [de

  7. Jim Walter Resources installs new overland conveyor

    Energy Technology Data Exchange (ETDEWEB)

    Fiscor, S.

    2008-12-15

    Embarking on a major expansion plan, the company is constructing a new additional overland conveyor coal to a recently refurbished prep plant. Jim Walter Resources recently invested $20 million in a new 5-mile overland conveyor system to haul coal from the No.7 deep coal mine in Alabama to the No.5 coal preparation plant. The size of the No.7 mine was effectively doubled. The article describes how this expansion move was decided upon and describes the design and installation of the new conveyor which spans approximately 5 miles. 4 photos.

  8. Walter Pater and the Language of Sculpture

    DEFF Research Database (Denmark)

    Østermark-Johansen, Lene

    are closely linked. Going beyond Pater's views on sculpture as an art form, this study traces the notion of relief (rilievo) and hybrid form in Pater, and his view of the writer as sculptor, a carver in language. Alongside her treatment of rilievo as a pervasive trope, Lene Østermark-Johansen also employs...... the idea of rivalry (paragone) more broadly, examining Pater's concern with positioning himself as an art critic in the late Victorian art world. Situating Pater within centuries of European aesthetic theories as never before done, Walter Pater and the Language of Sculpture throws new light...

  9. The essayistic style of Walter Benjamin:

    OpenAIRE

    Ceserani, Remo

    2010-01-01

    This paper examines the peculiar essayistic style of Walter Benjamin. All of the various genres of his writing have an allegorical and surrealistic quality, with hidden and private (and essayistic) meanings, but also with a prophetic, hallucinatory tension. Članek obravnava tipični esejistični stil Walterja Benjamina. Za vse žanre njegovega pisanja je značilna alegoričnost in surrealističnost s skritimi ter zasebnimi (in esejističnimi) pomeni, a tudi s preroško halucinatorično napetostjo....

  10. An Interview with Dr. Walter Lear

    Directory of Open Access Journals (Sweden)

    The Editors

    2009-03-01

    Full Text Available In this issue of the English version of Social Medicine we are publishing the first of several pamphlets loaned to us by the US Health Activism History Collection. To introduce this collection we travelled to Philadelphia on June 18, 2008 to interview Dr. Walter J. Lear. Dr Lear, born in 1923, is the person responsible for the collection. In a wide-ranging interview in his home Dr. Lear discussed his personal background, the origins and purpose of the collection, the impact of the McCarthy period on the US health left, as well as his vision for the future.

  11. Walter Benjamin ja lugemismõnu / Aija Sakova-Merivee

    Index Scriptorium Estoniae

    Sakova-Merivee, Aija, 1980-

    2014-01-01

    Arvustus: Benjamin, Walter. Lapsepõlv Berliinis 1900. aasta paiku : valik esseid. II / Walter Benjamin ; saksa keelest tõlkinud Mati Sirkel ; koostanud ja järelsõna: Marek Tamm. Tallinn : Kultuurileht, 2014. (Loomingu raamatukogu ; 2014, nr. 9/11)

  12. Walter Rowe Courtenay, Jr. (1933–2014)

    Science.gov (United States)

    Benson, Amy J.

    2016-01-01

    WALTER R. COURTENAY, JR., ichthyologist and retired professor, Florida Atlantic University, Boca Raton, Florida, died in Gainesville, Florida, on 30 January 2014 at age 80. Walt was born in Neenah, Wisconsin, on 6 November 1933, son of Walter and Emily Courtenay. Walt's interest in fish began at a young age as evidenced by a childhood diary in which at 13 years of age he wrote about his first catch—a two-and-a-half pound “pike” from Lake Winnebago. When Walt turned ten, the family moved from Wisconsin to Nashville, Tennessee, the move precipitated by his father accepting a position as pastor of the First Presbyterian Church. During those early days in Nashville, Walt's father would take summers off and travel to Michigan to teach at Camp Miniwanca along the shore of Lake Michigan where father and son honed their angling skills. It was also at that time Walt's father had definite views on what his son should be doing in adult life—in Walt's case it was to become a medical doctor. However, his Woods Hole internship in marine biology and oceanography toward the end of his undergraduate years was a transformative experience for him so much so that he abandoned all ideas of becoming a medical doctor and instead specialized in ichthyology and oceanography. Apart from the inherent interest and opportunities Woods Hole opened to him, being back at the shore of a large body of water, in this case the Atlantic Ocean, was far more interesting than sitting in lectures on organic chemistry. With that, Walt completed his B.A. degree at Vanderbilt University in 1956. In 1960 while in graduate school in Miami, Walt met and married Francine Saporito, and over the next several years had two children, Walter III and Catherine. He went on to receive his M.S. in 1961 from The Rosenstiel School of Marine and Atmospheric Science at the University of Miami on the systematics of the genus Haemulon (grunts) and his Ph.D. degree in 1965 working under his advisor C. Richard

  13. The Death and Life of Walter Benjamin

    Directory of Open Access Journals (Sweden)

    David Kishik

    2013-11-01

    Full Text Available What if Walter Benjamin actually made it to New York as he was escaping the Nazis, settling there for the rest of his long life? What if he was working on a sequel to his Arcades Project, translating his ideas about Paris, capital of the nineteenth century, to his new city and own epoch? And what if I inadvertently discovered the manuscript of this so-called Manhattan Project, and decided to write a study dedicated to the unearthed text? This paper offers a few reflections on, and quotations from, the book that I am currently, truly working on, which is an analysis of a phantom of a book, inspired by a real collection of reflections and quotations that were made in preparation for another book that was also never written.

  14. Walter Benjamin's allegory and the modernity

    Directory of Open Access Journals (Sweden)

    João Batista Pereira

    2013-12-01

    Full Text Available Committed since Classical Antiquity with the rhetoric and the rules of oratory, the allegory was like a displaced metaphor, striving for clarity of speech. That purpose was transfigured throughout the Middle Ages, when its use was linked to decency and morality, a convention which was changed in Romanticism, when it met its demise. From the texts proposed by Walter Benjamin, its existence was perceived as a resource illuminating the aesthetic universe in the social times, a figure of speech tied to the historical context. We adopt in this article a dialectical perspective as a methodological that more accurately illustrates the contours assumed by allegory in modernity. With the light of experiences in a changing world of insecurity in its own values, it is now envisioned as a category indicting of fragmented representation of society, allowing us to understand the limits of literature as a vehicle in critical of reality.

  15. Obituary: Walter Alexander Feibelman, 1930-2004

    Science.gov (United States)

    Oergerle, William

    2005-12-01

    Walter Alexander Feibelman, 79, an astronomer who discovered the E-ring of Saturn, died of a heart attack 19 November 2004 at his home at Riderwood Village in Silver Spring, Maryland. Walter was born 30 October 1925 in Berlin, Germany to Bernard and Dora Feibelman. He came to the United States with his parents in 1941. They were some of the last German Jews to flee Nazi Germany. Years later, he reported his experiences in an account contributed to the U.S. Holocaust Memorial Museum. As a youth, he worked at a cleaning shop and as a soda jerk before taking a course in tool and die making. He worked at the Abbey Photo Corp. in New York and in a model-making firm, where he constructed models of aircraft for use in identification courses by the Army Air Forces. After high school, he attended the Carnegie Institute of Technology and received his BS degree in 1956. Until 1969, he was a research scientist at the University of Pittsburgh. While working as an assistant research professor in physics and astronomy at the University of Pittsburgh in 1967, he examined a photo of Saturn taken a year earlier at the university's Allegheny Observatory. The E-ring -- unlike the bright main rings, A, B, C, D and F -- is faint and not easily spotted. He paired his observation with calculations and announced his discovery, which remained unconfirmed until the Pioneer 11 flyby in 1979. Walter joined the Optical Astronomy Division of Goddard Space Flight Center in Greenbelt in 1969, and worked there until 2002, when he became an emeritus astronomer at NASA. He became associated with the International Ultraviolet Explorer project, and worked on developing detectors for the orbiting observatory's spectrograph. The project turned out to be one of NASA's most successful observatories, operating from 1978 to 1996. In his scientific career, he published more than 200 refereed articles, mainly on hot stars and planetary nebulae. He also wrote papers in the fields of photography, spectroscopy

  16. Tectonic geomorphology of the Andes with SIR-A and SIR-B

    Science.gov (United States)

    Bloom, Arthur L.; Fielding, Eric J.

    1986-01-01

    Data takes from SIR-A and SIR-B (Shuttle Imaging Radar) crossed all of the principal geomorphic provinces of the central Andes between 17 and 34 S latitude. In conjunction with Thematic Mapping images and photographs from hand-held cameras as well as from the Large Format Camera that was flown with SIR-B, the radar images give an excellent sampling of Andean geomorphology. In particular, the radar images show new details of volcanic rocks and landforms of late Cenozoic age in the Puna, and the exhumed surfaces of tilted blocks of Precambrian crystalline basement in the Sierras Pampeanas.

  17. Baudelaire'i Pariis Walter Benjamini esseedes / Vappu Thurlow

    Index Scriptorium Estoniae

    Thurlow, Vappu, 1960-

    2006-01-01

    Marksismi kalduva Walter Benjamini kulturoloogilisest uurimusest, mis keskendub ühiskondlikule ja kultuurielule ning varases staadiumis olevale modernismile, mistõttu saab tema arutluskäikude keskseks kangelaseks Charles Baudelair kui flaneur

  18. Walter Isard's Contributions to Environmental Economics and Ecological Economics

    NARCIS (Netherlands)

    Rose, Adam; Folmer, Henk; Nijkamp, Peter

    This article summarizes Walter Isard's important contributions to environmental economics and ecological economics. The former is the traditional field that incorporates some limited aspects of the environment into neoclassical economic theory, while the latter is a more comprehensive integration of

  19. Sir Charles Scott Sherrington (1857–1952)

    Indian Academy of Sciences (India)

    Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from twentytwouniversities and ...

  20. Sir Ronald Ross and the Malarial Parasite

    Indian Academy of Sciences (India)

    1997-08-20

    Aug 20, 1997 ... In 1857, a General in the Indian Army, Sir C C G Ross and his wife Matilda .... generally low-caste Indians who required a fee before drinking the water and ... nary demand being made upon their systems, as by fatigue, chill,.

  1. Sir Ronald Ross and the Malarial Parasite

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 7. Sir Ronald Ross and the Malarial Parasite - Discovery of its Route - From Man to Mosquito and Back. Shobhona Sharma. General Article Volume 11 Issue 7 July 2006 pp 4-13 ...

  2. Sir Charles Scott Sherrington (1857–1952)

    Indian Academy of Sciences (India)

    2016-08-26

    Aug 26, 2016 ... Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from ...

  3. A public health physician named Walter Leser.

    Science.gov (United States)

    Mello, Guilherme Arantes; Bonfim, José Ruben de Alcântara

    2015-09-01

    A brief review of the career of the public health physician Walter Sidney Pereira Leser, who died in 2004 aged 94. Self-taught, from his 1933 doctoral thesis he became a country reference in the field of statistics and epidemiology, with dozens of studies and supervisions. In the clinical field he is one of the founders of Fleury Laboratory, and participates in the creation of CREMESP. As an academic, Leser was a professor at the Escola de Sociologia e Política de São Paulo, Escola Paulista de Medicina e Faculdade de Farmácia e Odontologia da USP. Also, Leser introduced objective tests in the college entrance examination, and led the creation of CESCEM and Carlos Chagas Foundation. In the Escola Paulista de Medicina he created the first Preventive Medicine Department of the country. As a public official, he was secretary of the State Department of Health of São Paulo between 1967 and 1971 and between 1975 and 1979, responsible for extensive reforms and innovations. Among the most remembered, the creation of sanitary medical career. Throughout this legacy, he lent his name to the "Medal of Honor and Merit Public Health Management" of the State of São Paulo.

  4. Thomas Walter Bannerman Kibble (1932 - 2016)

    CERN Document Server

    2016-01-01

    Tom Kibble, an internationally-renowned theoretical physicist, passed away on Thursday 2 June.   Tom Kibble in the CMS cavern during a visit to CERN in 2014. (Photo: CMS/CERN) Professor Thomas Walter Bannerman Kibble passed away unexpectedly on 2 June at the age of 83. He was senior research investigator at the Blackett Laboratory and Emeritus Professor of Theoretical Physics at Imperial College, London. He made seminal contributions to our current understanding of symmetries and symmetry breaking in the Standard Model of particle physics. He was among those who, in 1964, proposed the mechanism of spontaneous symmetry breaking in gauge theories, together with G. Guralnik and C. Hagen in the autumn of that year, following the papers by R. Brout and F. Englert and by P. Higgs. When this new understanding was incorporated into a model proposed by S. Glashow in 1961, it led to the first formulations of the Standard Model by S. Weinberg and A. Salam. Kibble deepened our under...

  5. Alfred Walter Campbell's return to Australia.

    Science.gov (United States)

    Macmillan, Malcolm

    2018-01-01

    Alfred Walter Campbell (1868-1937) established the basic cytoarchitectonic structure of the human brain while he was working as a pathologist at the Rainhill Lunatic Asylum near Liverpool in the United Kingdom. He returned to Australia in 1905 and continued doing research while establishing a neurological practice. His research over the next 17 years focused on four topics: (a) localisation in the cerebellum, (b) the neuroses and psychoses in war, (c) localisation in the cerebral cortex of the gorilla, and (d) the causes and pathology of the mysterious Australian "X" Disease (later known as Murray Valley encephalitis). In this article, I elaborate on his research in these areas, which provided evidence (a) against Louis Bolk's thesis that variation in the size of the cerebellar cortex reflected variation in the amount of cortex controlling various groups of muscle, (b) against the view that the neuroses and psychoses in war were different from those in civilian life, (c) for a parcelation of the cortex of the gorilla brain that supported his earlier findings in the higher apes, and (d) on the cause and pathophysiology of Australian "X" disease. Much of this research was overlooked, but it remains of considerable value and historical significance.

  6. Foreword: Sir John Pendry FRS Sir John Pendry FRS

    Science.gov (United States)

    Inglesfield, John; Echenique, Pedro

    2008-07-01

    scattering is much weaker, and this allowed him to develop a method of successive approximation. The material and the calculation are cut up into a series of atomic slices, and the electronic structure solved without approximation in each slice. Being two-dimensional, this was much more manageable than a full three-dimensional calculation. Then the slices could be put together by a sort of perturbation theory to calculate the scattering current as a function of energy along each of the reciprocal lattice 'rods' allowed by the surface periodicity. John didn't just stop at having solved the problem in principle, he also developed a suite of computer codes to do the job in a routine way. He even published the code for all to use, and I believe that to the present day the calculations are still done effectively in the same way. Without the calculations, one cannot interpret the data in terms of a surface atomic structure. Effectively one is doing a computer experiment in parallel to the laboratory experiment, and one fiddles more or less systematically with the surface structure until one gets agreement between the simulations and the laboratory data. One of the things that John noticed was that the process of photoemission (UPS) from a surface is rather similar, and can be calculated in an analogous way. This suddenly became very important because the new synchrotron at Daresbury was about to become operational, pumping out billions of photons for solid state research. Sam Edwards (now Sir Sam) was head of SRC (forerunner of EPSRC) at the time and recognised the problem of interpreting all the data that the machine would provide. And after UPS would come EXAFS, and after that XANES and all the rest of the alphabet soup. With that foresight, unusual at the time, John Pendry was appointed to head the theory group at Daresbury. Previously the theoreticians had revolved around the nuclear physics accelerator, and John had to turn it completely around and refocus it, which he did

  7. Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast.

    Science.gov (United States)

    Hannan, Abdul; Abraham, Neethu Maria; Goyal, Siddharth; Jamir, Imlitoshi; Priyakumar, U Deva; Mishra, Krishnaveni

    2015-12-02

    Silent information regulator 2 (Sir2), the founding member of the conserved sirtuin family of NAD(+)-dependent histone deacetylase, regulates several physiological processes including genome stability, gene silencing, metabolism and life span in yeast. Within the nucleus, Sir2 is associated with telomere clusters in the nuclear periphery and rDNA in the nucleolus and regulates gene silencing at these genomic sites. How distribution of Sir2 between telomere and rDNA is regulated is not known. Here we show that Sir2 is sumoylated and this modification modulates the intra-nuclear distribution of Sir2. We identify Siz2 as the key SUMO ligase and show that multiple lysines in Sir2 are subject to this sumoylation activity. Mutating K215 alone counteracts the inhibitory effect of Siz2 on telomeric silencing. SUMO modification of Sir2 impairs interaction with Sir4 but not Net1 and, furthermore, SUMO modified Sir2 shows predominant nucleolar localization. Our findings demonstrate that sumoylation of Sir2 modulates distribution between telomeres and rDNA and this is likely to have implications for Sir2 function in other loci as well. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  8. SIR - small is safe [in reactor design

    International Nuclear Information System (INIS)

    Hayns, M.

    1989-01-01

    A joint USA-UK venture has been initiated to design a small nuclear reactor which offers low capital cost, greater flexibility and a potentially lower environmental impact. Called Safe Integral Reactor (SIR), the lead unit could be built in the United Kingdom Atomic Energy Authority's (UKAEA's) Winfrith site if the design is accepted by the UK Nuclear Installations Inspectorate (NII). This article describes the 320 MWe reactor unit that is the basis of the design being developed. (author)

  9. The mitochondrial SIR2 related protein 2 (SIR2RP2 impacts Leishmania donovani growth and infectivity.

    Directory of Open Access Journals (Sweden)

    Nimisha Mittal

    2017-05-01

    Full Text Available Leishmania donovani, a protozoan parasite is the major causative agent of visceral leishmaniasis. Increased toxicity and resistance to the existing repertoire of drugs has been reported. Hence, an urgent need exists for identifying newer drugs and drug targets. Previous reports have shown sirtuins (Silent Information Regulator from kinetoplastids as promising drug targets. Leishmania species code for three SIR2 (Silent Information Regulator related proteins. Here, we for the first time report the functional characterization of SIR2 related protein 2 (SIR2RP2 of L. donovani.Recombinant L. donovani SIR2RP2 was expressed in E. coli and purified. The enzymatic functions of SIR2RP2 were determined. The subcellular localization of LdSIR2RP2 was done by constructing C-terminal GFP-tagged full-length LdSIR2RP2. Deletion mutants of LdSIR2RP2 were generated in Leishmania by double targeted gene replacement methodology. These null mutants were tested for their proliferation, virulence, cell cycle defects, mitochondrial functioning and sensitivity to known SIR2 inhibitors.Our data suggests that LdSIR2RP2 possesses NAD+-dependent ADP-ribosyltransferase activity. However, NAD+-dependent deacetylase and desuccinylase activities were not detected. The protein localises to the mitochondrion of the promastigotes. Gene deletion studies showed that ΔLdSIR2RP2 null mutants had restrictive growth phenotype associated with accumulation of cells in the G2/M phase and compromised mitochondrial functioning. The null mutants had attenuated infectivity. Deletion of LdSIR2RP2 resulted in increased sensitivity of the parasites to the known SIR2 inhibitors. The sirtuin inhibitors inhibited the ADP-ribosyltransferase activity of recombinant LdSIR2RP2. In conclusion, sirtuins could be used as potential new drug targets for visceral leishmaniasis.

  10. Walter User’s Manual (Version 1.0).

    Science.gov (United States)

    1987-09-01

    queries and/or commands. 1.2 - How Walter Uses the Screen As shown in Figure 1-1, Walter divides the screen of your terminal into five separate areas...our attention to queries and how to submit them to the database. 1.3.1 - Submitting Queries A query is an expression consisting of words, parentheses...dates, but also with ranges of dates, such as "oct 15 : nov 15". Waiter recognizes three kinds of dates: * Specific dates of the form [date <month> <day

  11. Obituary: Walter G. Egan, 1923-2003

    Science.gov (United States)

    Hilgeman, Theodore

    2009-01-01

    Walter G. Egan, a scientist and engineer with a professional life spanning well over half a century, died on 3 November 2003. Born to Caroline and George Egan on 12 October 1923 in New York City, Egan studied Electrical Engineering at the City College of New York from 1941 until 1943 when he was called to active duty in World War II, switching from enlisted reserve status. During the war, he served honorably in both the Signal Corps and the Medical Corps. Following his discharge in 1946, he resumed his college studies, obtaining a BEE in 1949 from City College of New York, an MA in Physics in 1951 from Columbia University, and a PhD in Solid State Physics in 1960 from the Polytechnic Institute of Brooklyn. Egan's PhD thesis was "Ferromagnetic Resonance in thin Nickel Films," performed under advisor H. Juretschke. Egan's professional career covered both industry and academia. In the summer of 1942, he worked for the Bruce Engineering Company. From 1957 to 1963, he worked for Ford Instrument Company, a Division of Sperry Rand Corporation, successively as an Engineering Project Supervisor, Assistant Director of Research, and Executive Assistant to the Director of Research. From 1964 to 1986 Egan worked as a Staff Scientist at the Grumman Corporation Corporate Research Center where his pioneering work consisted of research and development of remote sensing equipment and techniques for the remote sensing of terrestrial and space targets and backgrounds. I came to know and work with him during his tenure at the Grumman Corporation, where we co-authored many papers and a book. His insight into remote sensing engineering and research, shared willingly with younger colleagues, was a major stimulus to my future research in this field. Egan instilled a sense of discipline in publication, so our work could be shared with others in a timely way. This drive to share his knowledge with others also made him an excellent teacher. Subsequently, he held the position of Research

  12. Intoxication of sheep exposed to ozark milkweed (Asclepias viridis Walter).

    Science.gov (United States)

    Smith, R A; Scharko, P; Bolin, D; Hong, C B

    2000-12-01

    Some 20 sheep died 1 at a time on a farm in Fleming County, KY, in late July of 1999 after consumption of Asclepias viridis Walter. Major histological lesions were mild multifocal nonsuppurative myocarditis. Gross pathology revealed wet and heavy lungs. Many affected animals had a hunched appearance, and marked posterior paresis was also observed.

  13. Walter Dill Scott and the Student Personnel Movement

    Science.gov (United States)

    Biddix, J. Patrick; Schwartz, Robert A.

    2012-01-01

    Walter Dill Scott (1869-1955), tenth president of Northwestern University and pioneer of industrial psychology, is an essential architect of student personnel work. This study of his accomplishments, drawing on records from the Northwestern University archives, tells a story about the people he influenced and his involvement in codifying what was…

  14. Double-diffusive convection of compressible rotating Walters' (B ...

    African Journals Online (AJOL)

    user

    A great number of applications of such a flow in geophysics are found in a ... We have considered an infinite, horizontal, compressible electrically conducting Walters' (Model B′) fluid layer of .... Linearized stability theory and normal mode analysis .... boundaries the boundary conditions are (see Chandrasekhar, 1981). 2.

  15. Walter Kaufmann and the Advocacy of German Thought in America.

    Science.gov (United States)

    Soll, Ivan

    1997-01-01

    Examines the career and contributions of Walter Kaufmann. A refugee from Hitler's Germany, Kaufmann set himself the unlikely task of trying to revive interest in Hegel and Nietzsche in the United States. Kaufman's work as a translator, interpreter, and teacher of German philosophy had a long-term impact on U.S. intellectuals. (MJP)

  16. Storytelling for Ordinary, Practical Purposes (Walter Benjamin's "The Storyteller")

    Science.gov (United States)

    Pereira, Íris Susana Pires; Doecke, Brenton

    2016-01-01

    This essay explores the role that storytelling can play in teachers' learning. Walter Benjamin's "The Storyteller" provides a theoretical framework that enables us to highlight the complexity of the professional learning of teachers when they share stories about their everyday lives. We develop our argument by presenting two instances of…

  17. "Cet obscur objet du Désir"

    Directory of Open Access Journals (Sweden)

    Reto Melchior

    1996-09-01

    Full Text Available Luis Bunuel’s last film is based on Pierre Louÿs’ La Femme et le Pantin. This now forgotten bestseller, published in 1898, is drawn from Goya s painting El Pelele, in which four women are playing with a male puppet. In Pierre Louÿs’ novel this scene is inverted so that one woman with two faces plays with four men. In Cet Obscur Objet du Désir this “femme fatale” is interpreted by two actresses. The concentric structure of the film puts focus on a scene of being excluded from knowing. The technique of continually interrupting the flash-back sequences frustrates the audience because of its exclusion from the “real” course of events and gives rise to doubts whether the male protagonist tells the truth about his love-affair or whether he satisfies the curiosity of the audience by telling them Pierre Louÿs’ novel as his own story. This ambiguous art of narration mirrors Bunuel’s claim that the main topic of Cet Obscur Objet du Désir is frustration.

  18. [Sir Francis Galton: the father of eugenics].

    Science.gov (United States)

    Aubert-Marson, Dominique

    2009-01-01

    Not only was Sir Francis Galton a famous geographer and statistician, he also invented "eugenics" in 1883. Eugenics, defined as the science of improving racial stock, was developed from a new heredity theory, conceived by Galton himself, and from the evolution theory of Charles Darwin, transposed to human society by Herbert Spencer. Galton's eugenics was a program to artificially produce a better human race through regulating marriage and thus procreation. Galton put particular emphasis on "positive eugenics", aimed at encouraging the physically and mentally superior members of the population to choose partners with similar traits. In 1904, he presented his ideas in front of a vast audience of physicians and scientists in London. His widely-publicized lecture served as the starting point for the development of eugenics groups in Europe and the United States during the first half of the 20th century.

  19. Walter Benjamin i l'aura de l'autobiografia

    OpenAIRE

    Martí Monterde, Antoni, 1968-

    2006-01-01

    És la biblioteca una forma d'autobiografia? Només caldria un sol escrit que ho demostrés de manera plena per a afirmar que sí, i aquest text el va escriure Walter Benjamin, qui el 17 de juliol de 1931 va publicar, a Die literarische Welt, 'un discurs sobre el col·leccionisme' sota el títol 'Tot desembolicant la meua biblioteca'.

  20. Sir Victor Horsley: pioneer craniopharyngioma surgeon.

    Science.gov (United States)

    Pascual, José M; Prieto, Ruth; Mazzarello, Paolo

    2015-07-01

    Sir Victor Horsley (1857-1916) is considered to be the pioneer of pituitary surgery. He is known to have performed the first surgical operation on the pituitary gland in 1889, and in 1906 he stated that he had operated on 10 patients with pituitary tumors. He did not publish the details of these procedures nor did he provide evidence of the pathology of the pituitary lesions operated on. Four of the patients underwent surgery at the National Hospital for Neurology and Neurosurgery (Queen Square, London), and the records of those cases were recently retrieved and analyzed by members of the hospital staff. The remaining cases corresponded to private operations whose records were presumably kept in Horsley's personal notebooks, most of which have been lost. In this paper, the authors have investigated the only scientific monograph providing a complete account of the pituitary surgeries that Horsley performed in his private practice, La Patologia Chirurgica dell'Ipofisi (Surgical Pathology of the Hypophysis), written in 1911 by Giovanni Verga, Italian assistant professor of anatomy at the University of Pavia. They have traced the life and work of this little-known physician who contributed to the preservation of Horsley's legacy in pituitary surgery. Within Verga's pituitary treatise, a full transcription of Horsley's notes is provided for 10 pituitary cases, including the patients' clinical symptoms, surgical techniques employed, intraoperative findings, and the outcome of surgery. The descriptions of the topographical and macroscopic features of two of the lesions correspond unmistakably to the features of craniopharyngiomas, one of the squamous-papillary type and one of the adamantinomatous type. The former lesion was found on necropsy after the patient's sudden death following a temporal osteoplastic craniectomy. Surgical removal of the lesion in the latter case, with the assumed nature of an adamantinomatous craniopharyngioma, was successful. According to the

  1. First measurement of 153Sm in the SIR

    International Nuclear Information System (INIS)

    Michotte, C.; Ratel, G.; Lucas, L.

    1999-01-01

    In June 1998, the NIST sent to the International Reference System (SIR) a solution of 153 Sm standardized in a 4π ionization chamber. As this radionuclide had not previously been measured in the SIR, the resulting equivalent activity A e,NIST is compared with the value calculated from the efficiency curve of the SIR. However, problems occurred owing to the presence of 154 Eu and 156 Eu impurities in the solution. The manner in which the final equivalent activity value for this solution of 153 Sm has been deduced is described in this report. (authors)

  2. Sir William Mitchell (1925-2002)

    CERN Multimedia

    2002-01-01

    Sir William (Bill) Mitchell, former President of the CERN Council, died on 30th October 2002 at the age of 77. Mitchell was professor of Physics at Oxford University from 1978 to 1989, having previously been Professor of Physics, Dean of Science and Deputy Vice-Chancellor at Reading University. From 1985 to 1990 he was Chairman of the UK's Science and Engineering Research Council (SERC), which at the time was the funding agency for the UK's participation in the CERN programme. As Chairman, Mitchell was one of the UK representatives on the CERN Council, and in 1991 he was elected President, a position he held for three years. This was a difficult period for CERN. Financial problems were being faced in many member states, notably in Germany as a result of unification. This led to calls for reductions in the CERN budget and, more significantly, to requests for delays in consderation of future programmes. On the other hand for the future of CERN and the progress of elementary particle physics, it was necessary...

  3. One day, Sir, you may tax it

    CERN Multimedia

    2011-01-01

    “One day, Sir, you may tax it”… Those are the words I used to get the audience's attention during my talk at the World Economic Forum’s annual meeting in Davos, where I was invited to speak about the science agenda in 2011. For those of you who don’t know the quote, it was Michael Faraday’s response to William Gladstone when asked to comment on the utility of his blue-sky research into the newfangled phenomenon of electricity.   So what does a 19th century English scientist have to do with the science agenda today? A great deal, I would contend. Faraday was doing basic science, but he had the foresight to realise that through applied research his findings could one day be developed into something taxable – as it turned out, electric light. Faraday had a sense of the potential of his blue-sky research, but he also appreciated that basic science alone is not enough. This was my key message in Davos. Governments often speak of ...

  4. Sir Robert Sidney’s Poems Revisited: the alternative sequence

    OpenAIRE

    Relvas, Maria de Jesus C.

    1997-01-01

    The essay approaches the lyric sequence written by Sir Robert Sidney (1563-1626) in the Elizabethan age, by mainly exploring its unique formal structure, which encloses an alternative sequence formed by a re-numbering of several poems.

  5. Validation of the Spanish SIRS with monolingual Hispanic outpatients.

    Science.gov (United States)

    Correa, Amor A; Rogers, Richard; Hoersting, Raquel

    2010-09-01

    Psychologists are faced with formidable challenges in making their assessment methods relevant to growing numbers of Hispanic clients for whom English is not the primary or preferred language. Among other clinical issues, the determination of malingering has profound consequences for clients. In this investigation, we evaluated a Spanish translation of the Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1992) with 80 Spanish-speaking Hispanic American outpatients. Using a between-subjects simulation design, the Spanish SIRS was found to produce reliable results with small standard errors of measurement. Regarding validity, very large effect sizes (mean Cohen's d= 2.00) were observed between feigners and honest responders for the SIRS primary scales. We consider the potential role of the Spanish SIRS with reference to Spanish translations for other assessment instruments.

  6. Walter Lippmann’s Ethical Challenge to the Individual

    Directory of Open Access Journals (Sweden)

    Steve Urbanski

    2012-01-01

    Full Text Available This essay analyzes in hermeneutic fashion random concepts of the individual from three of philosopher Walter Lippmann’s major works, Liberty and the News, Public Opinion, and The Phantom Public. The article addresses the following: By considering Lippmann’s multileveled representation of the individual, 21st-century media professionals can become empowered to avoid emotivism and strive toward a more narrative-based form of ethics. The article compares and contrasts Lippmann’s representation of the individual with John Dewey’s Great Community and Daniel Boorstin’s notion of the pseudo-event.

  7. Walter Gropius no Brasil: revisitando críticas

    OpenAIRE

    Rodrigo Marcondes Rocha

    2013-01-01

    O tema desta dissertação de mestrado nasce do interesse pela obra e pela figura do arquiteto alemão Walter Gropius (1883-1969) e enfoca sua passagem pelo Brasil em janeiro de 1954, quando participou como destaque da Exposição Internacional de Arquitetura (evento integrante da II Bienal Internacional de Artes de São Paulo, que por sua vez coincidia com as comemorações do IV Centenário da fundação da cidade), recebeu o Prêmio São Paulo de Arquitetura, em sua primeira e única e...

  8. The Daughters of Fire: Walter Hugo Khouri's female gothic

    Directory of Open Access Journals (Sweden)

    Daniel Serravalle de Sá

    2012-11-01

    This article seeks to investigate the connections between WalterHugo Khouri’s film As Filhas do Fogo (1978 and the Gothicstressing matters of gender, race and nationality. More than asimple re-classification, this Gothic framework of study seeks todemonstrate that the representation of necromancy, mysteriousdeaths and female imprisonment in a tropical manor suggest issueslinked to Brazilian cultural identity and concerns. By associatingKhouri’s film to a form that is representative of popularentertainment this article seeks to establish a case in point ofhow the notion of Gothic can be a useful concept in the investigationof Brazilian film history.

  9. Abysmal Language. The Mystic of the Language in Walter Benjamin

    OpenAIRE

    Emiliano Mendoza Solís

    2014-01-01

    Walter Benjamin expone en su ensayo de juventud denominado “Sobre el lenguaje en cuanto tal y sobre el lenguaje del hombre” (1916), los aspectos más importantes relativos a la teoría del lenguaje. La idea de lenguaje está fundamentadamediante el examen de los contenidos espirituales del hombre y surelación con el ser lingüístico. Esta distinción condiciona a la teoría a permanecer sobre el abismo que anida en el interior de la entidad espiritual del lenguaje. El elemento abismal da lugar a un...

  10. PROTAGONISM OF AMERICAN INDIANS IN WALTER LANTZ'S CARTOONS

    Directory of Open Access Journals (Sweden)

    Rafael Duarte Oliveira Venancio

    2011-06-01

    Full Text Available Condemned to a dubious media representation in early cinema through the novels of the late nineteenth century, the North American Indians never had a high profile in films of this period. However, an animator, Walter Lantz, has a high degree of characterization of Native Americans in his work. The aim of this paper is to study the role of Native Americans in these cartoons and analyze the social implications of these choices, using the concepts of apparatus and formula. Furthermore, the analysis will include a portrayal of the American media scene before and after Lantz, seeking disruptions and legacies.

  11. Development of Immunopathobiogenesis on SIRS-Sepsis

    Directory of Open Access Journals (Sweden)

    A Guntur Hermawan

    2009-04-01

    Full Text Available Over the past decade, sepsis has been diagnosed according to consensus guidelines established in 1991 as an infection in addition to the symptoms of systemic inflammatory response syndrome (SIRS. In addition to the previous criteria, the 2001 conference added several new diagnostic criteria for sepsis. Of particular interest was the inclusion of the biomarkers procalcitonin (PCT and C-reactive protein (CRP, despite the overall conclusion that it was premature to use biomarkers for sepsis diagnosis. The primary recommendation of the panel was the implementation of the Predisposition, insult Infection, Response, and Organ dysfunction (PIRO.The immune system has traditionally been devided into innate and adaptive components, each of which has a different role and function in defending the host against infectious agents. Stimulation of different TLRs induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also increasing evidence supports an additional critical role for TLRs in orchestrating the development of adaptive immune responses. The superantigens are able to induce toxic shock syndrome and can sometimes cause multiple organ failure via adaptive immune system. The superantigenic activity of the bacterial exotoxins can be attributed to their ability to cross-link major histocompatibility complex class II molecules on antigen-presenting cells outside the peptide groove with T-cell receptors to form a trimolecular complex. This trimolecular interaction leads to uncontrolled release of a number of proinflammatory cytokines. Proinflammatory cytokines especially IFN-γ and TNF-α, the key cytokines causing toxic shock syndrome. KEYWORDS: sepsis, innate immunity, adaptive.

  12. Walter Charleton (1620 - 1707 e sua Teoria Atômica The atomic theory of walter charleton (1620 - 1707

    Directory of Open Access Journals (Sweden)

    Paulo Alves Porto

    1997-06-01

    Full Text Available Several authors in the 17th century used the atomic hypothesis to explain observable phenomena. This paper analyzes some ideas about chemical transformation proposed by the English physician Walter Charleton. In Physiologia Epicuro-Gassendo-Charltoniana (London, 1654, Charleton examined philosophical aspects of the atomic theory, and suggested that the best explanation for all natural phenomena would be only in terms of atoms and their motions. Sometimes, however, he had to attribute to the atoms some kind of "internal virtue", to explain more complex properties of the matter. His idea of "element", and the little use of experimentation and quantification, also limited the range of Charleton's theory.

  13. Walter Benjamin, historia cultural y fotografía

    Directory of Open Access Journals (Sweden)

    Maria Isabel Zapata Villamil

    2004-06-01

    Full Text Available In this article we will see that Walter Benjamin's construction of a concept of history is not based only on thinkers like Marx, Freud or Nietzsche. For Benjamin, certain works of art were sources of great inspiration. Besides pointing out this wide range of sources, my interest is in highlighting Benjamin’sinterest in images as sources. Benjamin considers iconography, mass production of art and technical aspects of photographic reproduction.//A lo largo de este artículo veremos cómo Walter Benjamin no se basará únicamente en pensadores como Marx, Freud y Nietzsche para construir su concepción de la historia. Para él serán también fuentes de inspiración fundamental algunas obras artísticas. Además de destacar esta amplia gama de fuentes mi interés es resaltar su acercamiento a estas últimas, principalmente con relación a las imágenes. Para referirse a ellas Benjamin considerará: La interpretación de lo iconográfico, la consideración del arte de masas y el estudio de la técnica reproductiva.

  14. Lymphocyte integrin expression differences between SIRS and sepsis patients.

    Science.gov (United States)

    Heffernan, D S; Monaghan, S F; Ayala, Alfred

    2017-11-01

    Systemic Inflammatory Response Syndrome (SIRS) and sepsis remain leading causes of death. Despite many similarities, the two entities are very distinct clinically and immunologically. T-Lymphocytes play a key pivotal role in the pathogenesis and ultimately outcome following both SIRS and sepsis. Integrins are essential in the trafficking and migration of lymphocytes. They also serve vital roles in efficient wound healing and clearance of infections. Here, we investigate whether integrin expression, specifically β1 (CD29) and β2 (CD18), are disrupted in SIRS and sepsis, and assess differences in integrin expression between these two critically ill clinical categories. T-Lymphocytes were isolated from whole blood collected from ICU patients exhibiting SIRS or sepsis. Samples were analyzed for CD18 (β2) and CD29 (β1) on CD3 + T cells through flow cytometry. Septic patients were stratified into either exclusively abdominal or non-abdominal sources of sepsis. CD18 was almost ubiquitously expressed on CD3 + T cells irrespective of clinical condition. However, CD29 (β1 integrin) was lowest in SIRS patients (20.4% of CD3 + T cells) when compared with either septic patients (35.5%) or healthy volunteers (54.1%). Furthermore, there was evidence of compartmentalization in septic patients, where abdominal sources had a greater percentage of CD3 + CD29 + T cells (41.7%) when compared with those with non-abdominal sources (29.5%). Distinct differences in T-cell integrin expression exists between patients in SIRS versus sepsis, as well as relative to the source of sepsis. Further work is needed to understand cause and effect relative to the progression from SIRS into sepsis.

  15. "Un paysage hanté, intense comme l'opium". Ville et notion de paysage selon Siegfried Kracauer et Walter Benjamin

    DEFF Research Database (Denmark)

    Reeh, Henrik

    2001-01-01

    bykultur, filosofi, Walter Benjamin, Siegfried Kracauer, Berlin, Paris, landskab, begrebet bylandskab......bykultur, filosofi, Walter Benjamin, Siegfried Kracauer, Berlin, Paris, landskab, begrebet bylandskab...

  16. Abysmal Language. The Mystic of the Language in Walter Benjamin

    Directory of Open Access Journals (Sweden)

    Emiliano Mendoza Solís

    2014-01-01

    Full Text Available Walter Benjamin expone en su ensayo de juventud denominado “Sobre el lenguaje en cuanto tal y sobre el lenguaje del hombre” (1916, los aspectos más importantes relativos a la teoría del lenguaje. La idea de lenguaje está fundamentadamediante el examen de los contenidos espirituales del hombre y surelación con el ser lingüístico. Esta distinción condiciona a la teoría a permanecer sobre el abismo que anida en el interior de la entidad espiritual del lenguaje. El elemento abismal da lugar a una revelación o principio (arché vinculadoa la mística del lenguaje.

  17. SIR-2 Data Normalization and Integration with M3 Data

    Science.gov (United States)

    Grumpe, A.; Felder, M. P.; Wöhler, C.; Mall, U.

    2013-09-01

    The point spectrometer SIR-2 on Chandrayaan-1 provided radiance spectra integrated over circular footprints of 200 m diameter in the wavelength range 934-2410.8 nm in 256 channels [1]. To analyze SIR-2 reflectance spectra in their spatial context, a coregistration to Chandrayaan-1 M³ hyperspectral images [2] as well as a correction for topography and thermal emission are inevitable. The thermal and topographic correction procedure is based on the surface temperature and a digital elevation model (DEM) inferred from M³ data. The corrected reflectance spectra are then normalized to a standard illumination and viewing geometry.

  18. On the Shoulders of Sir Isaac Newton and Arthur Storer

    Science.gov (United States)

    Martin, Helen E.; Evans-Gondo, Bonita

    2013-01-01

    Helen E. Martin, the author of this article, is a retired National Board Certified Teacher who has been researching Sir Isaac Newton's unpublished manuscripts for over three decades. While researching the work of Newton, a teacher she was mentoring asked for some hands-on activities to study planetary motion. The description of the activity…

  19. Sir William Jenner (1815-1898) and Queen Victoria.

    Science.gov (United States)

    Seddon, David; Queen Victoria

    2004-08-01

    This biographical note outlines the work of Sir William Jenner (1815-1898), court physician 1861-93 and President of the Royal College of Physicians 1881-8. He was the first to distinguish between typhoid and typhus both clinically and pathologically.

  20. Investigating The Travelling Wave Solution For an SIR Endemic ...

    African Journals Online (AJOL)

    This paper presents the travelling wave solution for an SIR endemic disease model with no disease related death when the spatial spread of the susceptible is not negligible. In this case the disease is driven by both the susceptible and the infective classes. The population is open since the disease is habitually prevalent in ...

  1. Buffels (Wes), Elsies, Sir Lowry's pass, Steenbras and Buffels (Oos)

    CSIR Research Space (South Africa)

    Heinecken, TJE

    1982-06-01

    Full Text Available This report is a synthesis of all available information on five of the smaller rivers discharging in to False bay combined as a single volume. The rivers dealt with are the Buffels (Wes), Elsies, Sir Lowry' Pass, Steenbras and Buffels (Oos). False...

  2. Sir John and Lady Rita Cornforth: a distinguished chemical partnership.

    Science.gov (United States)

    Purchase, Rupert; Hanson, James R

    2015-01-01

    This review describes the life of Sir John Cornforth AC CBE FRS, who was awarded the Nobel Prize for Chemistry in 1975. It covers his early life in Australia, his work in Oxford, the National Institute for Medical Research, the Milstead Laboratory of Chemical Enzymology and the University of Sussex, together with the contributions made by his wife, Lady Rita Cornforth.

  3. Science and controversy a biography of Sir Norman Lockyer

    CERN Document Server

    Meadows, A

    2008-01-01

    Sir Norman Lockyer left Nature, the world''s leading scientific journal, as his lasting memorial. But his life, and controversial theories, are an important part of science history. His ideas were at the forefront of public debate, and ranged from brilliant to perverse. This entertaining book is a fascinating insight into his eventful life

  4. Walter Cronkite Speaks to Teachers...(and That's the Way It Is).

    Science.gov (United States)

    Cronkite, Walter; Martorelli, Debra

    1980-01-01

    In this interview with "Instructor" assistant editor Debra Martorelli, respected television journalist Walter Cronkite discusses the amount of time children spend watching television, public concerns with the schools, and the news media's coverage of education. (SJL)

  5. Heat transfer in MHD flow of dusty viscoelastic (Walters' liquid model ...

    Indian Academy of Sciences (India)

    fluid in porous medium on a parallel plate channel inclined at an angle θ. ... temperature field, Nusselt number, skin friction and flow flux are obtained within the channel. The ... Walters [2] proposed a theoretical model for elastoviscous fluids.

  6. Täiustatud tõde ehk Walter Andersoni rahvajuttude enesekontrolli seadus / Elo-Hanna Seljamaa

    Index Scriptorium Estoniae

    Seljamaa, Elo-Hanna, 1980-

    2007-01-01

    Geograafilis-ajaloolise meetodi lähtealuste ja eesmärkide toel analüüsitakse Walter Andersoni, Tartu Ülikooli esimese folkloristikaprofessori käsitlusi folkloorist ja folkloori uurimisest ning tema tegevust meetodi edasiarendajana

  7. AFSC/ABL: Little Port Walter Marine Research Station Supply Run Oceanographic Observations

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In November, 2006, Oceanographic observations were initiated during the resupply cruises to the Little Port Walter Research Station on lower Baranof Island,...

  8. Microsoft PowerPoint - Walter Coke Comm May 19 Karen correction presentation [Compatibility Mode

    Science.gov (United States)

    Contains slides from a presentation to Collegeville, Harriman Park, and Fairmont neighborhoods in North Birmingham, Alabama updating the community on the environmental sampling and next steps on the Walter Coke cleanup site.

  9. STS-55 MS1/PLC Ross monitors Payload Specialist Walter's Anthrorack activity

    Science.gov (United States)

    1993-01-01

    STS-55 German Payload Specialist 1 Ulrich Walter breathes into Rack 9 Anthrorack (AR) (Human Physiology Laboratory) device for Pulmonary Perfusion and Ventilation During Rest and Exercise experiment while working inside the Spacelab Deutsche 2 (SL-D2) science module aboard the Earth-orbiting Columbia, Orbiter Vehicle (OV) 102. Seated on the bicycle ergometer, Walter utilizes the respiratory monitoring system, part of a broad battery of experiments designed to investigate human physiology under microgravity conditions. In the background, Mission Specialist 1 (MS1) and Payload Commander (PLC) Jerry L. Ross monitors Walter's activity. Walter represents the German Aerospace Research Establishment (DLR) on the 10-day SL-D2 mission. Visible on the aft end cone are a fire extinguisher and the Crew Telesupport Experiment (CTE) Macintosh portable computer mounted on an adjustable work platform.

  10. Walter Benjamin e Paris: individualidade e trabalho intelectual

    Directory of Open Access Journals (Sweden)

    Renato Ortiz

    2000-05-01

    Full Text Available Este artigo é uma leitura do texto de Walter Benjamin Paris capital do século XIX. A partir do conjunto de anotações que Benjamin faz de diversos livros consultados, principalmente durante sua pesquisa na Bibliothèque Nationale, o autor pretende trabalhar a noção de indivíduo vinculando-a a dois temas. Primeiro, a emergência do flâneur como tradução do espírito de mobilidade que se inaugura com a modernidade. Para isso a discussão sobre a noção de espaço, particularmente no que diz respeito a cidade de Paris, é importante. O flâneur surge assim como um indivíduo desenraizado que se locomove através do espaço urbano remodelado. Segundo, uma aproximação entre o ato da flânerie e o trabalho intelectual. Considerando a flânerie como uma atividade intelectual o autor mostra como os temas do distanciamento e da construção do objeto são relevantes tanto para o flâneur-detetive quanto para a reflexão nas ciências sociais.This paper is an interpretation of Walter Benjamins Paris, Capital of the 19th Century. Based on the notes Benjamin made on several books he read, mainly during his research at the Bibliotèque Nationale, the author discusses the notion of the individual linking it to two themes. First, to the emergence of the flâneur as a translation of the spirit of mobility which starts with modernity. The discussion on the notion of space, especially where it concerns Paris, is essential for this analysis. The flâneur is seen as an uprooted individual who moves around the remodelled urban space. Second, to the proximity between the act of flânerie and that of intellectual work. Taking flânerie to be intellectual activity, the author shows how the themes of the distancing and the construction of the object are relevant, both to the detective-flâneur and to the reflection in social sciences.

  11. 33 CFR 147.817 - Sir Douglas Morpeth Tension Leg Platform safety zone.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Sir Douglas Morpeth Tension Leg... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.817 Sir Douglas Morpeth Tension Leg Platform safety zone. (a) Description. The Sir Douglas Morpeth Tension Leg Platform (Morpeth...

  12. Fragments on black swan: money, credit and finance in The Arcades Project of Walter Benjamin

    OpenAIRE

    Estrada, Fernando

    2010-01-01

    The main objective of this paper is to present a reading of The Arcades Project by Walter Benjamin in the context of the financial crisis, in particular, reflect from a few fragments of Benjamin's work appear to lie around a Black Swan. The recovery of the fragments of The Arcades seems appropriate at a time when the financial crisis should be taught as a deeper crisis. Walter Benjamin is placed beyond its time, with a powerful sense of observation worthy of emulation analytical.

  13. Auf den Spuren des verschollenen Polarforschers Baron Eduard Toll und seines Freundes Hermann Walter auf der Kotelny-Insel / Erki Tammiksaar, Roland Walter, Hans-Otto von Walter... [jt.

    Index Scriptorium Estoniae

    Tammiksaar, Erki, 1969-

    2011-01-01

    Baltisakslaste koostööst kuulsa vene polaaruurija Dmitri Šparoga seoses baltisaksa polaaruurija Hermann Walteri säilmete ringimatmisega Kotelnõi saarel. Hermann Walter osales Eduard von Tolli Sannikovi maa otsimise ekspeditsioonis. Hermann Walteri põhjalik iseloomustus

  14. Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states.

    Directory of Open Access Journals (Sweden)

    Stephanie Kueng

    Full Text Available Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM loci in budding yeast. We have performed a detailed biochemical and genetic analysis of the largest Sir protein, Sir4. The N-terminal half of Sir4 is dispensable for SIR-mediated repression of HM loci in vivo, except in strains that lack Yku70 or have weak silencer elements. For HM silencing in these cells, the C-terminal domain (Sir4C, residues 747-1,358 must be complemented with an N-terminal domain (Sir4N; residues 1-270, expressed either independently or as a fusion with Sir4C. Nonetheless, recombinant Sir4C can form a complex with Sir2 and Sir3 in vitro, is catalytically active, and has sedimentation properties similar to a full-length Sir4-containing SIR complex. Sir4C-containing SIR complexes bind nucleosomal arrays and protect linker DNA from nucleolytic digestion, but less effectively than wild-type SIR complexes. Consistently, full-length Sir4 is required for the complete repression of subtelomeric genes. Supporting the notion that the Sir4 N-terminus is a regulatory domain, we find it extensively phosphorylated on cyclin-dependent kinase consensus sites, some being hyperphosphorylated during mitosis. Mutation of two major phosphoacceptor sites (S63 and S84 derepresses natural subtelomeric genes when combined with a serendipitous mutation (P2A, which alone can enhance the stability of either the repressed or active state. The triple mutation confers resistance to rapamycin-induced stress and a loss of subtelomeric repression. We conclude that the Sir4 N-terminus plays two roles in SIR-mediated silencing: it contributes to epigenetic repression by stabilizing the SIR-mediated protection of linker DNA; and, as a target of phosphorylation, it can destabilize silencing in a regulated manner.

  15. Il desiderio Kitsch: i troppi paradisi di Walter Siti

    Directory of Open Access Journals (Sweden)

    Ornella Tajani

    2013-06-01

    Full Text Available Cosa ne è del desiderio all’interno del Kitsch, sistema in cui la vita è vissuta come uno spot pubblicitario e l’identità come una eterna performance? In una dimensione utopistica in cui l’uomo non cerca altro che una continua soddisfazione come possono trovare spazio le tensioni e le mancanze che muovono il desiderio? Dopo una premessa teorica su cosa è il Kitsch, l’intervento si propone di rispondere al quesito attraverso tre opere di Walter Siti: i romanzi Troppi paradisi e Autopsia dell’ossessione e il reportage narrativo Il canto del diavolo. In queste opere vengono individuati tre paradigmi dell’esperienza Kitsch: il turismo, la televisione e un certo tipo di prostituzione. Indagandone le modalità e analizzando le riflessioni dell’autore in merito si vedrà come si deforma il desiderio quando si trova a dover fare i conti con il perpetuo sforzo del Kitschmensch di camuffarsi, per dirla con Kundera, «dans le miroir du mensonge embellissant et de s’y reconnaître avec une satisfaction émue». La meravigliosa e sostenibilissima leggerezza dell’essere che assurge a cifra interpretativa dell’utopia Kitsch non prevede la presenza del desiderio se non nella sua veste di “realizzabilità”: il desiderio Kitsch, il surrogato del desiderio, è offerto in omaggio col prodotto che lo appaga.

  16. Gerard Manley Hopkins and Walter Pater : the labyrinths of transience

    Directory of Open Access Journals (Sweden)

    Mirko Starčević

    2016-12-01

    Full Text Available Transience forming life's very essence left an indelible mark on the creative explorations of Gerard Manley Hopkins and Walter Pater. The permanently indeterminable presence of mutability made both of them face the umbrous and unknowable aspect of death, thus revealing unto them the task of determining the role of art in life ruled by ceaseless corrosion. Pater accepts the flux of mutability as the primary particle in the revelatory act of the authentic creative experience. The power of that which is frolicsome in art augments the constitution of life's essence submerged in the unsettled condition of fate. Hopkins the priest particularly in his theoretic excursions recognizes in art itself only an approximate value to the timeless grandeur of God's ubiquity. His poetry, however, presents a dissimilar narrative. The poetic image that Hopkins forges corresponds to the mode of exposed individuality of the Romantic spirit, which Pater perceives as the harmony of strangeness and beauty. During Hopkins' student days at Oxford, Pater's relationship to the young poet was not confined to coaching only. Much of their time they spent in conversation, meditating upon the essential principles of artistic expression. Pater influenced Hopkins greatly and contributed impressively to the discipline of his poetic heart. Traces of this companionship do not find the path to Hopkins' religious ruminations; they announce their own existence, although very subtly, upon the individual levels of Hopkins' poetic yearnings.

  17. Sir Karl Popper and his philosophy of physics

    Science.gov (United States)

    Jammer, Max

    1991-12-01

    The eminent mathematical physicist Sir Hermann Bondi once said: “There is no more to science than its method, and there is no more to its method than Popper has said.” Indeed, many regard Sir Karl Raimund Popper the greatest philosopher of science in our generation. Much of what Popper “has said” refers to physics, but physicists, generally speaking, have little knowledge of what he has said. True, Popper's philosophy of science and, in particular, his realistic interpretation of quantum mechanics deviates considerably from the generally accepted doctrine. But as Popper, rightly I think, points out, it is precisely the proliferation of divergent theories which promotes the growth of scientific knowledge; it would be a danger for physics if physicists were dogmatically tied to a single theory or would not test their theory against alternatives. It is for this purpose that, on the occasion of the nonagenarian celebration of Popper's birthday, the present essay has been written.

  18. The susceptible-infected-recovered (SIR) model for viral marketing

    Science.gov (United States)

    Ismail, Siti Suhaila; Akil, Ku Azlina Ku; Chulan, Majdah; Sharif, Noorzila

    2017-11-01

    Viral marketing is a marketing strategy utilizes social media to spread information about a product or services provided. It is the most powerful way to share information in a short amount of time. The objective of this study is to investigate the dynamic of viral marketing within a time duration in the point of view of mathematics. This study used the epidemiological model known as Susceptible-Infected-Recovered (SIR). The model consists of a system of three differential equations with three state variables namely susceptible (S), infected (I) and recovered (R). It considers a case of SIR model with demography. Numerical experiments have been performed. The results show that viral marketing reaches its peak within two days. The online messages shared will become higher if the initial number of the infected individual has been increased.

  19. Stability analysis of the Euler discretization for SIR epidemic model

    International Nuclear Information System (INIS)

    Suryanto, Agus

    2014-01-01

    In this paper we consider a discrete SIR epidemic model obtained by the Euler method. For that discrete model, existence of disease free equilibrium and endemic equilibrium is established. Sufficient conditions on the local asymptotical stability of both disease free equilibrium and endemic equilibrium are also derived. It is found that the local asymptotical stability of the existing equilibrium is achieved only for a small time step size h. If h is further increased and passes the critical value, then both equilibriums will lose their stability. Our numerical simulations show that a complex dynamical behavior such as bifurcation or chaos phenomenon will appear for relatively large h. Both analytical and numerical results show that the discrete SIR model has a richer dynamical behavior than its continuous counterpart

  20. The Systemic Inflammatory Response Syndrome (SIRS in acutely hospitalised medical patients: a cohort study

    Directory of Open Access Journals (Sweden)

    Storgaard Merete

    2009-12-01

    Full Text Available Abstract Background Sepsis is an infection which has evoked a systemic inflammatory response. Clinically, the Systemic Inflammatory Response Syndrome (SIRS is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in medical emergency ward patients is unknown. Methods We conducted a prospective cohort study of the frequency of SIRS and its relationship to sepsis and death among acutely hospitalised medical patients. In 437 consecutive patients, SIRS status, blood pressure, infection and comorbidity on admission was registered together with 28-day mortality. Results A hundred and fifty-four patients (35% had SIRS on admission, 211 patients (48% had no SIRS, and 72 patients (16% had insufficient data to evaluate their SIRS status. SIRS patients were 2.2 times more frequently infected, with 66/154 SIRS patients versus 41/211 non-SIRS patients: p Conclusion We found SIRS status on admission to be moderately associated with infection and strongly related to 28-day mortality.

  1. SirT1 regulates energy metabolism and response to caloric restriction in mice.

    Directory of Open Access Journals (Sweden)

    Gino Boily

    Full Text Available The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utilize ingested food. These mice are hypermetabolic, contain inefficient liver mitochondria, and have elevated rates of lipid oxidation. When challenged with a 40% reduction in caloric intake, normal mice maintained their metabolic rate and increased their physical activity while the metabolic rate of SirT1-null mice dropped and their activity did not increase. Moreover, CR did not extend lifespan of SirT1-null mice. Thus, SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction.

  2. Stability and bifurcation analysis in a delayed SIR model

    International Nuclear Information System (INIS)

    Jiang Zhichao; Wei Junjie

    2008-01-01

    In this paper, a time-delayed SIR model with a nonlinear incidence rate is considered. The existence of Hopf bifurcations at the endemic equilibrium is established by analyzing the distribution of the characteristic values. A explicit algorithm for determining the direction of the Hopf bifurcation and the stability of the bifurcating periodic solutions are derived by using the normal form and the center manifold theory. Numerical simulations to support the analytical conclusions are carried out

  3. [Sir Harold Ridley--the creator of modern cataract surgery].

    Science.gov (United States)

    Obuchowska, Iwona; Mariak, Zofia

    2005-01-01

    In February 2000, the worldwide ophthalmology community celebrated the 50th anniversary of one of the twentieth century's most important innovations in eye care--the implantation of the first intraocular lens after cataract extraction by Sir Harold Ridley. It was the initiation of a golden age for the development of ophthalmology, especially cataract surgery. In our paper we would like to remember this outstanding English ophthalmologist and his great invention.

  4. Development of SIR-C Ground Calibration Equipment

    Science.gov (United States)

    Freeman, A.; Azeem, M.; Haub, D.; Sarabandi, K.

    1993-01-01

    SIR-C/X-SAR is currently scheduled for launch in April 1994. SIR-C is an L-Band and C-Band, multi-polarization spaceborne SAR system developed by NASA/JPL. X- SAR is an X-Band SAR system developed by DARA/ASI. One of the problems involved in calibrating the SIR-C instrument is to make sure that the horizontal (H) and vertical (V) polarized beams are aligned in the azimuth direction, i.e.. that they are pointing in the same direction. This is important if the polarimetric performance specifications for the system are to be met. To solve this problem, we have designed and built a prototype of a low-cost ground receiver capable of recording received power from two antennas, one H-polarized, the other V-polarized. The two signals are mixed to audio then recorded on the left and right stereo channels of a standard audio cassette player. The audio cassette recording can then be played back directly into a Macintosh computer, where it is digitized. Analysis of.

  5. The firms Sandvik Coromant and Walter instruments choice algorithmization

    Directory of Open Access Journals (Sweden)

    Євген Іванович Іванов

    2015-11-01

    Full Text Available This article describes the typical algorithms for choosing modern tools made by foreign firms Sandvik Coromant and Walter. The use of modern tools is effective on both new and old equipment. Algorithms ensure orderly operation of engineers in the development of new or upgrading old processes, and may also be useful for students enrolled in the specialty "Mechanical Engineering". The use of modern tools is effective on both new and old equipment. Correctly chosen tool make it possible for you to quickly recoup the cost of new equipment and significantly improve the work of the old equipment. Currently, all cutting tools can be divided into the following groups: a a solid; b composite; c assembly; d modular (dial-up. In composite cutting tools and parts theholders are attached permanently. For example, the attachment can be blocked by welding or soldering. At modular and modular cutting tools and parts are detachable. In those parts of the modular tool there are separate assembly units (modules with standardized mounting surface. Thus one and the same cutter head may be attached to a holder (mandrel housings of different configuration and function. The choice of the cutting part of such tools includes determining the shape and size of the indexable insert (SMP, the geometry of its front surface, corner radius and tool material. Selecting the holder (mandrel body includes determining its type and size. It is necessary to take into account the possibility of technological equipment (type and size of the mounting surfaces of the tool holder and tool spindle.After selecting the tool it is necessary to determine working regimes

  6. Taking Charge: Walter Sydney Adams and the Mount Wilson Observatory

    Science.gov (United States)

    Brashear, R.

    2004-12-01

    The growing preeminence of American observational astronomy in the first half of the 20th century is a well-known story and much credit is given to George Ellery Hale and his skill as an observatory-building entrepreneur. But a key figure who has yet to be discussed in great detail is Walter Sydney Adams (1876-1956), Hale's Assistant Director at Mount Wilson Observatory. Due to Hale's illnesses, Adams was Acting Director for much of Hale's tenure, and he became the second Director of Mount Wilson from 1923 to 1946. Behind his New England reserve Adams was instrumental in the growth of Mount Wilson and thus American astronomy in general. Adams was hand-picked by Hale to take charge of stellar spectroscopy work at Yerkes and Mount Wilson and the younger astronomer showed tremendous loyalty to Hale and Hale's vision throughout his career. As Adams assumed the leadership role at Mount Wilson he concentrated on making the observatory a place where researchers worked with great freedom but maintain a high level of cooperation. This paper will concentrate on Adams's early years and look at his growing relationship with Hale and how he came to be the central figure in the early history of Mount Wilson as both a solar and stellar observatory. His education, his years at Dartmouth and Yerkes (including his unfortunate encounter with epsilon Leonis), and his formative years on Mount Wilson are all important in learning how he shaped the direction of Mount Wilson and the development of American astronomy in the first half of the 20th century. This latter history cannot be complete until we bring Adams into better focus.

  7. Walter Benjamin's concept of aura and the cultural industry

    Directory of Open Access Journals (Sweden)

    Bráulio Santos Rabelo de Araújo

    2010-12-01

    Full Text Available Trata-se de uma análise do texto A obra de arte na era da reprodutibilidade técnica, de 1935, de Walter Benjamin, no qual o autor analisa as alterações provocadas pelas novas técnicas de produção artística na esfera da cultura, e desenvolve, como elemento principal, a tese de a reprodutibilidade técnica provocar a superação da aura pela obra de arte. Tendo como apoio o contraste do texto de Benjamin com o texto A indústria cultural: O esclarecimento como mistificação das massas, de Theodor Adorno e Max Horkheimer, de 1947, e a observação da produção do cinema, da música e do livro (artes necessariamente reprodutíveis, este artigo (a analisa a tese da superação do conceito de aura pela obra de arte na era da reprodutibilidade técnica, (b contrasta essa tese com a reflexão sobre indústria cultural de Adorno e Horkheimer e com as características da obra de arte produzida no decorrer do século 20 e início do século 21, e (c apresenta as contribuições que podem ser retiradas dessa análise para a atual reflexão a respeito dos impactos da Internet e das tecnologias digitais sobre a produção cultural contemporânea. Como resultado principal e do qual decorre outras conclusões, o artigo considera que as técnicas analisadas por Benjamin, apesar de terem tornado a obra de arte independente de um substrato único, não a emanciparam de seu caráter aurático. Os elementos centrais da aura (autenticidade e unicidade não foram superados, mas, ao contrário, adaptaram-se às mudanças técnicas, adaptação essa que ocorreu em torno da industrialização, a qual marcou a produção cultural no século 20.

  8. An SIRS model with a nonlinear incidence rate

    International Nuclear Information System (INIS)

    Jin Yu; Wang, Wendi; Xiao Shiwu

    2007-01-01

    The global dynamics of an SIRS model with a nonlinear incidence rate is investigated. We establish a threshold for a disease to be extinct or endemic, analyze the existence and asymptotic stability of equilibria, and verify the existence of bistable states, i.e., a stable disease free equilibrium and a stable endemic equilibrium or a stable limit cycle. In particular, we find that the model admits stability switches as a parameter changes. We also investigate the backward bifurcation, the Hopf bifurcation and Bogdanov-Takens bifurcation and obtain the Hopf bifurcation criteria and Bogdanov-Takens bifurcation curves, which are important for making strategies for controlling a disease

  9. Sir Winston Churchill: treatment for pneumonia in 1943 and 1944.

    Science.gov (United States)

    Vale, J A; Scadding, J W

    2017-12-01

    This paper reviews Churchill's illnesses in February 1943 and August/September 1944 when he developed pneumonia; on the first occasion this followed a cold and sore throat. Churchill was managed at home by Sir Charles Wilson (later Lord Moran) with the assistance of two nurses and the expert advice of Dr Geoffrey Marshall, Brigadier Lionel Whitby and Colonel Robert Drew. A sulphonamide (sulphathiazole on the first occasion) was prescribed for both illnesses. Churchill recovered, and despite his illnesses continued to direct the affairs of State from his bed. On the second occasion, Churchill's illness was not made public.

  10. Sir Rudolf Peierls Selected private and scientific correspondence

    CERN Document Server

    Lee, Sabine

    2007-01-01

    This edition of the private and scientific correspondence of Sir Rudolf Peierls gives a unique insight into the life and work of one of the greatest theoretical physicists of the 20th century. Rudolf Peierls' scientific work contributed to the early developments in quantum mechanics, and he is well known and much appreciated for his contributions to various disciplines, including solid state physics, nuclear physics, and particle physics. As an enthusiastic and devoted teacher, he passed on his knowledge and understanding and inspired the work of collaborators and students alike. As an effecti

  11. Sir Ronald A. Fisher and the International Biometric Society.

    Science.gov (United States)

    Billard, Lynne

    2014-06-01

    The year 2012 marks the 50th anniversary of the death of Sir Ronald A. Fisher, one of the two Fathers of Statistics and a Founder of the International Biometric Society (the "Society"). To celebrate the extraordinary genius of Fisher and the far-sighted vision of Fisher and Chester Bliss in organizing and promoting the formation of the Society, this article looks at the origins and growth of the Society, some of the key players and events, and especially the roles played by Fisher himself as the First President. A fresh look at Fisher, the man rather than the scientific genius is also presented. © 2014, The International Biometric Society.

  12. The Rolf and Gertrud Dahlgren Prize for 2017 Awarded to Hans Walter Lack

    DEFF Research Database (Denmark)

    Friis, Ib

    2018-01-01

    The reasons for awarding the Rolf and Gertrud Dahlgren Prize to Hans Walter Lack are summarised and the prize described. It is also mentioned that Rosén's Linnaeus Medal in Gold was awarded to Arne Strid at the same ceremony.......The reasons for awarding the Rolf and Gertrud Dahlgren Prize to Hans Walter Lack are summarised and the prize described. It is also mentioned that Rosén's Linnaeus Medal in Gold was awarded to Arne Strid at the same ceremony....

  13. Walter Schottky. Atom-theorist and electrotechnician. His life and work until the year 1941; Walter Schottky. Atomtheoretiker und Elektrotechniker. Sein Leben und Werk bis ins Jahr 1941

    Energy Technology Data Exchange (ETDEWEB)

    Serchinger, Reinhard W.

    2008-07-01

    In this first scientific biography of Walter Schottky at the one hand the origin of his scientific and technical works is reproduced and put in the physical-historical connection of his time. At the other hand his special role in the research strategy of the Siemens company becomes clear, which could in the framework of this research project for the first time be identified. Also psychological aspects were essentially included in the study, because else the binding of the particular more corresponding to an ivory-tower than and industrial physicist personality of Schottky to the Siemens trust not would be understandable. The example of Walter Schottky shows the importance of the researching individuum, which until today undoubtly can be an important element of company-internal innovation processes not only contrarily but also in the transition to scientific team work.

  14. SIR-ZEE: plataforma tecnológica para el desarrollo local SIR-ZEE: technology platform for local development

    Directory of Open Access Journals (Sweden)

    Marlen Treviño Villalobos

    2012-11-01

    Full Text Available El Sistema de Información Regional de la Zona Económica Especial (SIR-ZEE nació en Costa Rica aproximadamente en 1998, cuando se concibió la idea de crear un sistema informático para recopilar, gestionar y ofrecer temáticas generadas en forma digital por diferentes entidades públicas y privadas. En el 2008, con los fondos del Programa de Regionalización Interuniversitaria del Consejo Nacional de Rectores, se aprobó la iniciativa SIR-ZEE, Plataforma Tecnológica para el Desarrollo Local, que buscó fortalecer las capacidades productivas y las capacidades de gobernabilidad en la Región Huetar Norte mediante el acceso a la información oportuna y relevante para el desarrollo económico local. Este artículo tiene como objetivo mostrar no solo la relevancia de un sistema de información en la planificación del desarrollo local, sino también que, en la actualidad, el SIR-ZEE se está convirtiendo en una ventaja competitiva para la Región Huetar Norte, ya que facilita el proceso de toma decisiones. Los principales resultados obtenidos al final de la iniciativa fueron una propuesta metodológica para la elaboración de planes estratégicos de desarrollo local en la Región Huetar Norte, la sensibilización de los actores locales sobre la participación ciudadana en las diferentes fases de la planificación, un diagnóstico territorial con el valor agregado de contar con la información georreferenciada y disponible en un sitio web, y avances en la elaboración del Plan estratégico de desarrollo local.The Regional Information System of the Special Economic Zone (SIR-ZEE was born about the year 1998 as a computer system to collect, manage and offer thematic generated in digital format by different public and private entities. In 2008, with the funds of Interuniversity Regionalization Program the National Council of Rectors approved the initiative SIR- ZEE: Platform Technology for Local Development which sought to strengthen productive

  15. A Novel Method of SIR Measurement for Power Control in CDMA Systems

    International Nuclear Information System (INIS)

    Yu, J; Wu, S B; He, J Z

    2006-01-01

    CDMA is interference limited multiple access system. Power control is an effective way to reduce co-channel interference and solve the near-far problem. Consequently, it can improve the system capacity, and make higher data rate possible. CDMA2000 employs fast closed-loop power control in reverse link to combat channel fading, and the estimation of signal to interference ratio (SIR) is required for closed-loop power control. Transmitting power is adjusted by comparing the SIR estimation with SIR target. So, it is crucial to measure the SIR of received signal accurately. Traditional measurement methods mostly depend on pilot signal strongly, when the pilots are few, there is a greater error brought to the measurement of SIR. In this paper, we discuss the SIR measurement of the received signal under the fewer pilots condition (especially only one pilot symbol) and present a novel SIR measurement method. According to the simulation, the numerical results indicate that the SIR measured by the proposed method is more accurate than the SIR measured by conventional method under fewer pilots condition

  16. Sir Victor Horsley (1857-1916): pioneer of neurological surgery.

    Science.gov (United States)

    Tan, Tze-Ching; Black, Peter McL

    2002-03-01

    Immortalized in surgical history for the introduction of "antiseptic wax," Sir Victor Horsley played a pivotal role in shaping the face of standard neurosurgical practice. His contributions include the first laminectomy for spinal neoplasm, the first carotid ligation for cerebral aneurysm, the curved skin flap, the transcranial approach to the pituitary gland, intradural division of the trigeminal nerve root for trigeminal neuralgia, and surface marking of the cerebral cortex. A tireless scientist, he was a significant player in discovering the cure for myxedema, the eradication of rabies from England, and the invention of the Horsley-Clarke stereotactic frame. As a pathologist, Horsley performed research on bacteria and edema and founded the Journal of Pathology. Horsley's kindness, humility, and generous spirit endeared him to patients, colleagues, and students. Born to privilege, he was nonetheless dedicated to improving the lot of the common man and directed his efforts toward the suffrage of women, medical reform, and free health care for the working class. Knighted in 1902 for his many contributions to medicine, Sir Victor met an untimely death during World War I from heat stroke at the age of 59. An iconoclast of keen intellect, unlimited energy, and consummate skill, his life and work justify his epitaph as a "pioneer of neurological surgery."

  17. Sir William Osler's speech at Troy: a Trojan horse?

    Science.gov (United States)

    Moran, Michael E

    2012-01-01

    Troy, New York, is a city of 55,000 people in upstate New York located along the Hudson River. A city of surprisingly rich cultural heritage, it was the home of New York state's first hospital outside New York City. The 50th anniversary celebration of Troy's hospital brought William Osler to the city as the keynote speaker. This speech, delivered on November 28, 1900, is one of Sir William's less well known addresses. Osler began his comments with Sir Thomas More's Utopia and talked at length about the hospital, its obligations, the influences it has upon the community, and the role of physicians and surgeons. He broached one of his old saws, the salary of attending physicians and their needed role in hospital management. His words were published in the diamond jubilee's records, but the hospital did not outlive its prominent guest professor, and it closed its doors in 1914. Just like the great historical city of Troy, New York's own Troy was on the brink of decline, and its hospital would be the first fatality. Therefore, it is almost prescient that the words of Osler, taken into historical context juxtaposed against the socioeconomic forces at work, are akin to the Greek's offering of a wooden edifice to end the Trojan War.

  18. Seeing and Playing as Labor: Toward a Visual Materialist Pedagogy of Video Games through Walter Benjamin

    Science.gov (United States)

    Bulut, Ergin

    2013-01-01

    In this article, the author draws specifically on the work of Walter Benjamin and engages with the world of video games by focusing on the constitution of labor as it unfolds in modding practices, as well as approaching the very act of seeing labor in a highly visual culture where value is extracted not just through the labor process but also…

  19. Le cercle mythique: Walter Benjamin sur la politique et son interruption

    NARCIS (Netherlands)

    van Rooden, A.

    2014-01-01

    This contribution starts from the idea that it is not so much pre-modern political orders that appeal to mythical logic, but contemporary ones. Lacking an external authority, contemporary political orders cannot but erect themselves in an act of auto-constitution. With reference to Walter Benjamin’s

  20. Meeting Opposites: The Political Theologies of Walter Benjamin and Carl Schmitt

    NARCIS (Netherlands)

    de Wilde, M.

    2011-01-01

    This article analyzes the critical dialogue between Walter Benjamin and Carl Schmitt, to which a letter and several references in their work testify. It shows how affinities and differences between their respective positions can be explained from a shared theologico-political approach. Both authors

  1. Notas sobre narração e experiência em Walter Benjamin

    Directory of Open Access Journals (Sweden)

    Wagner de Avila Quevedo

    2008-12-01

    Full Text Available O objetivo deste texto é o de elucidar alguns escritos clássicos sobre o conceito de experiência (Erfahrung em Walter Benjamin, mostrando sua relação com a narração (Erzählung e a memória.

  2. Magic, Mimesis, and Revolutionary Praxis: Illuminating Walter Benjamin's Rhetoric of Redemption.

    Science.gov (United States)

    DeChaine, D. Robert

    2000-01-01

    Outlines the rhetorical contributions of Walter Benjamin, who attempted to develop a social critique arguing for the decisive function of critical intervention. Suggests Benjamin's insights about the liberatory role of the engaged social agent warrant closer attention. Proposes his ideas provide useful avenues for examining contemporary texts and…

  3. Enlightening City Childhoods: Walter Benjamin's Berlin and Erich Kästner's Dresden

    Science.gov (United States)

    Lathey, Gillian

    2016-01-01

    Walter Benjamin, cultural critic and philosopher, compiled "Berlin childhood around 1900" (trans. Howard Eiland, 2006) while in exile from Germany in the early 1930s, filtering impressions of a privileged childhood through a politicised adult consciousness. Erich Kästner, journalist, poet, satirist and author of the children's classic…

  4. The Bauhaus Artist-Teacher: Walter Gropius's Philosophy of Art Education

    Science.gov (United States)

    Daichendt, G. James

    2010-01-01

    Walter Gropius built the internationally known movement and art school known as the Bauhaus between the years 1919 and 1928. This new institution was born by combining two fledging schools: the Weimar School of Arts and Crafts with the Weimar Academy of Fine Arts. In this new academy all media were regarded as acceptable as Gropius sought to…

  5. Virtualizing the Word: Expanding Walter Ong's Theory of Orality and Literacy through a Culture of Virtuality

    Science.gov (United States)

    Dempsey, Jennifer Camille

    2014-01-01

    This dissertation seeks to create a vision for virtuality culture through a theoretical expansion of Walter Ong's literacy and orality culture model. It investigates the ubiquitous and multimodal nature of the virtuality cultural phenomenon that is mediated by contemporary technology and not explained by pre-existing cultural conventions. Through…

  6. Critique of art : Walter Benjamin and Theodor W. Adorno on art criticism

    NARCIS (Netherlands)

    Lijster, Thijs Erik

    2012-01-01

    Kunstkritiek vervult een cruciale rol als medium tussen het kunstwerk en de maatschappelijke werkelijkheid. Dat concludeert promovendus Thijs Lijster. Daarbij moet kunstkritiek, in navolging van Walter Benjamin en Theodor Adorno, niet in de eerste plaats opgevat worden als het beoordelen van

  7. 77 FR 59899 - Proposed Information Collection; Comment Request; Coastal Zone Management Act Walter B. Jones and...

    Science.gov (United States)

    2012-10-01

    ... Collection; Comment Request; Coastal Zone Management Act Walter B. Jones and NOAA Excellence Awards AGENCY... approved information collection. The 1990 reauthorization of the Coastal Zone Management Act (CZMA) authorized an awards program to ``implement a program to promote excellence in coastal zone management by...

  8. Taking Care of Business: Walter Carpenter and the Management of American Enterprise.

    Science.gov (United States)

    Cheape, Charles W.

    1996-01-01

    Evaluates the life and career of DuPont corporate executive, Walter Carpenter, and uses it to illustrate the rise of the managerial class. Neither owners nor entrepreneurs, managers like Carpenter used their intelligence and skill to reorganize and expand the companies the companies where they worked. (MJP)

  9. Book review: Decolonisation and border thinking: Walter D. Mignolo, disobeying modern reason

    Directory of Open Access Journals (Sweden)

    Jordi Quero

    2015-12-01

    Full Text Available Mignolo, Walter D. Habitar la frontera: Sentir y pensar la descolonialidad (Antología, 1999-2014. Carballo, Francisco y Herrera Robles, Luis Alfonso (prólogo y selección. CIDOB, 2015 505 págs.

  10. Walter Scandale receives the decoration of Knight of the Order of Merit of the Italian Republic

    CERN Multimedia

    2008-01-01

    On 9 December 2008, Walter Scandale, a member of the EN Department, received the decoration of Knight of the Order of Merit of the Italian Republic, one of Italy's highest decorations. He was awarded the medal by the Consul-General of Italy in Geneva.

  11. Towards a Critique of Educative Violence: Walter Benjamin and "Second Education"

    Science.gov (United States)

    Charles, Matthew

    2016-01-01

    Although modern systems of mass education are typically defined in their opposition to violence, it has been argued that it is only through an insistent and critical focus upon violence that radical thought can be sustained. This article seeks to take up this challenge in relation to Walter Benjamin's lesser known writings on education. Benjamin…

  12. "Cracking Open the Natural Teleology": Walter Benjamin, Charles Fourier and the Figure of the Child

    Science.gov (United States)

    Dolbear, Sam; Proctor, Hannah

    2016-01-01

    The French utopian socialist Charles Fourier is a key figure in Walter Benjamin's "Arcades Project". For Benjamin, one of the most significant aspects of Fourier's utopian vision was its conceptualisation of work as a form of play. According to Fourier it would be possible to build a world around people's inherent desires. In such a…

  13. Permanence for a Delayed Nonautonomous SIR Epidemic Model with Density-Dependent Birth Rate

    Directory of Open Access Journals (Sweden)

    Li Yingke

    2011-01-01

    Full Text Available Based on some well-known SIR models, a revised nonautonomous SIR epidemic model with distributed delay and density-dependent birth rate was considered. Applying some classical analysis techniques for ordinary differential equations and the method proposed by Wang (2002, the threshold value for the permanence and extinction of the model was obtained.

  14. Dynamical Analysis of SIR Epidemic Models with Distributed Delay

    Directory of Open Access Journals (Sweden)

    Wencai Zhao

    2013-01-01

    Full Text Available SIR epidemic models with distributed delay are proposed. Firstly, the dynamical behaviors of the model without vaccination are studied. Using the Jacobian matrix, the stability of the equilibrium points of the system without vaccination is analyzed. The basic reproduction number R is got. In order to study the important role of vaccination to prevent diseases, the model with distributed delay under impulsive vaccination is formulated. And the sufficient conditions of globally asymptotic stability of “infection-free” periodic solution and the permanence of the model are obtained by using Floquet’s theorem, small-amplitude perturbation skills, and comparison theorem. Lastly, numerical simulation is presented to illustrate our main conclusions that vaccination has significant effects on the dynamical behaviors of the model. The results can provide effective tactic basis for the practical infectious disease prevention.

  15. Sir Robert Ball: Victorian Astronomer and Lecturer par excellence

    Science.gov (United States)

    Jones, R. I. G.

    2005-12-01

    Between 1875 and 1910 Sir Robert Stawell Ball gave an estimated 2,500 lectures in towns and cities all over the British Isles and abroad. This paper traces his lecturing career from its beginnings in Ireland to the triumphs of the Royal Institution, and on lecture tours in the United States of America. After a period in mathematics and mechanics, he became a populariser of science, especially astronomy, and found fame and fortune among the working classes and the aristocracy. What motivated him to tireless travels is uncertain, but it might have been that it was rewarding, financially and to his reputation. Whatever his motives, contemporary accounts are clear that BallÕs lectures were extremely popular and well-received.

  16. Microstrip Cross-coupled Interdigital SIR Based Bandpass Filter

    Directory of Open Access Journals (Sweden)

    R. K. Maharjan

    2012-09-01

    Full Text Available A simple and compact 4.9 GHz bandpass filter for C-band applications is proposed. This paper presents a novel microstrip cross-coupled interdigital half-wavelength stepped impedance resonator (SIR based bandpass filter (BPF.The designed structure is similar to that of a combination of two parallel interdigital capacitors. The scattering parameters of the structure are measured using vector network analyzer (VNA. The self generated capacitive and inductive reactances within the interdigital resonators exhibited in a resonance frequency of 4.9 GHz. The resonant frequency and bandwidth of the capacitive cross-coupled resonator is directly optimized from the physical arrangement of the resonators. The measured insertion loss (S21 and return loss (S11 were 0.3 dB and 28 dB, respectively, at resonance frequency which were almost close to the simulation results.

  17. Vaccination strategies for SIR vector-transmitted diseases.

    Science.gov (United States)

    Cruz-Pacheco, Gustavo; Esteva, Lourdes; Vargas, Cristobal

    2014-08-01

    Vector-borne diseases are one of the major public health problems in the world with the fastest spreading rate. Control measures have been focused on vector control, with poor results in most cases. Vaccines should help to reduce the diseases incidence, but vaccination strategies should also be defined. In this work, we propose a vector-transmitted SIR disease model with age-structured population subject to a vaccination program. We find an expression for the age-dependent basic reproductive number R(0), and we show that the disease-free equilibrium is locally stable for R(0) ≤ 1, and a unique endemic equilibrium exists for R(0) > 1. We apply the theoretical results to public data to evaluate vaccination strategies, immunization levels, and optimal age of vaccination for dengue disease.

  18. SIR (Safe Integral Reactor) - reducing size can reduce cost

    International Nuclear Information System (INIS)

    Hayns, M.R.

    1991-01-01

    Traditional engineering economics have favoured the advantages of larger size as a means of reducing specific capital costs and hence unit generating costs. For large and small plants utilising the same concept, e.g. a small four-loop PWR vs a large four-loop PWR with the same number of components, economies of scale are well established. If, however, a smaller plant is sized to take advantage of features which are only feasible at smaller outputs, is of simpler design, with the advantage taken of the simplified design to produce the most cost-effective layout, and incorporates fewer, more easily replaceable components with minimal assembly on site, it is possible to produce a plant which is competitive with larger plant of more traditional design. When 'system' effects, such as better matching of installed capacity to the growth in demand and the fact that a smaller total capacity will be needed to meet a given demand with a specified level of confidence, are taken into account, it can be shown that a utility's overall cash-flow position can be improved with lower associated absolute financial risks. The UK/US Safe Integral Reactor (SIR) is an integral pressurized water reactor in the 300-400 MW(e) range which utilises conventional water reactor technology in a way not feasible at the very large, sizes of recent years. The SIR concept is briefly explained and its technical and economic advantages in terms of simplicity, construction, maintenance, availability, decommissioning, safety and siting described. The results of system analyses which demonstrate the overall financial advantages to a utility are presented. (author)

  19. Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.

    Science.gov (United States)

    Gallo, Christopher M; Smith, Daniel L; Smith, Jeffrey S

    2004-02-01

    The Saccharomyces cerevisiae Sir2 protein is an NAD(+)-dependent histone deacetylase (HDAC) that functions in transcriptional silencing and longevity. The NAD(+) salvage pathway protein, Npt1, regulates Sir2-mediated processes by maintaining a sufficiently high intracellular NAD(+) concentration. However, another NAD(+) salvage pathway component, Pnc1, modulates silencing independently of the NAD(+) concentration. Nicotinamide (NAM) is a by-product of the Sir2 deacetylase reaction and is a natural Sir2 inhibitor. Pnc1 is a nicotinamidase that converts NAM to nicotinic acid. Here we show that recombinant Pnc1 stimulates Sir2 HDAC activity in vitro by preventing the accumulation of NAM produced by Sir2. In vivo, telomeric, rDNA, and HM silencing are differentially sensitive to inhibition by NAM. Furthermore, PNC1 overexpression suppresses the inhibitory effect of exogenously added NAM on silencing, life span, and Hst1-mediated transcriptional repression. Finally, we show that stress suppresses the inhibitory effect of NAM through the induction of PNC1 expression. Pnc1, therefore, positively regulates Sir2-mediated silencing and longevity by preventing the accumulation of intracellular NAM during times of stress.

  20. Walter Reed Army Medical Center (WRAMC) and Office of Management and Budget (OMB) Circular A-76: Implications for the Future

    National Research Council Canada - National Science Library

    Grasso, Valerie B

    2007-01-01

    This report examines the issues surrounding the recent Walter Reed public-private competition conducted under OMB Circular A-76 and its potential impact on future Department of Defense competitions...

  1. The neurosurgeon as baseball fan and inventor: Walter Dandy and the batter's helmet.

    Science.gov (United States)

    Brewster, Ryan; Bi, Wenya Linda; Smith, Timothy R; Gormley, William B; Dunn, Ian F; Laws, Edward R

    2015-07-01

    Baseball maintains one of the highest impact injury rates in all athletics. A principal causative factor is the "beanball," referring to a pitch thrown directly at a batter's head. Frequent morbidities elicited demand for the development of protective gear development in the 20th century. In this setting, Dr. Walter Dandy was commissioned to design a "protective cap" in 1941. His invention became widely adopted by professional baseball and inspired subsequent generations of batting helmets. As a baseball aficionado since his youth, Walter Dandy identified a natural partnership between baseball and medical practice for the reduction of beaning-related brain injuries. This history further supports the unique position of neurosurgeons to leverage clinical insights, inform innovation, and expand service to society.

  2. Jean-Louis Déotte, Walter Benjamin et la forme plastique. Architecture, technique, lieux

    OpenAIRE

    Brabant, Dominik

    2014-01-01

    Une longue fréquentation de Walter Benjamin a permis à Jean-Louis Déotte de construire, progressivement, par touches successives et motifs récurrents sans cesse repris et retravaillés, une figure de l’œuvre qui n’en soit pas la simple exégèse toujours recommencée, mais bien la reconfiguration constante de son lieu, du site de son avoir-lieu, si l’on considère l’œuvre-Benjamin à l’image d’un événement. Walter Benjamin et la forme plastique constitue à cet égard une étape importante, sans postu...

  3. SirR, a Novel Iron-Dependent Repressor in Staphylococcus epidermidis

    Science.gov (United States)

    Hill, Philip J.; Cockayne, Alan; Landers, Patrick; Morrissey, Julie A.; Sims, Catriona M.; Williams, Paul

    1998-01-01

    In Staphylococcus epidermidis and Staphylococcus aureus, a number of cell wall- and cytoplasmic membrane-associated lipoproteins are induced in response to iron starvation. To gain insights into the molecular basis of iron-dependent gene regulation in the staphylococci, we sequenced the DNA upstream of the 3-kb S. epidermidis sitABC operon, which Northern blot analysis indicates is transcriptionally regulated by the growth medium iron content. We identified two DNA sequences which are homologous to elements of the Corynebacterium diphtheriae DtxR regulon, which controls, in response to iron stress, for example, production of diphtheria toxin, siderophore, and a heme oxygenase. Upstream of the sitABC operon and divergently transcribed lies a 645-bp open reading frame (ORF), which codes for a polypeptide of approximately 25 kDa with homology to the DtxR family of metal-dependent repressor proteins. This ORF has been designated SirR (staphylococcal iron regulator repressor). Within the sitABC promoter/operator region, we also located a region of dyad symmetry overlapping the transcriptional start of sitABC which shows high homology to the DtxR operator consensus sequence, suggesting that this region, termed the Sir box, is the SirR-binding site. The SirR protein was overexpressed, purified, and used in DNA mobility shift assays; SirR retarded the migration of a synthetic oligonucleotide based on the Sir box in a metal (Fe2+ or Mn2+)-dependent manner, providing confirmatory evidence that this motif is the SirR-binding site. Furthermore, Southern blot analysis of staphylococcal chromosomal DNA with the synthetic Sir box as a probe confirmed that there are at least five Sir boxes in the S. epidermidis genome and at least three in the genome of S. aureus, suggesting that SirR controls the expression of multiple target genes. Using a monospecific polyclonal antibody raised against SirR to probe Western blots of whole-cell lysates of S. aureus, S. carnosus, S. epidermidis

  4. The creation of an Alternative Subjectivity in Walter Mosley's Detective Novels.

    OpenAIRE

    Reyes Torres, Agustín

    2008-01-01

    Walter Mosley reappropriates the detective conventions to represent the American society of the 1950s and 1960s from a marginal perspective. He creates a black private eye, Easy Rawlins, whose profile mirrors that of his white counterparts but also subverts it. This thesis analyzes Raymond Chandlers canonical work The Simple Art of Murder and establish those traits that characterize Easy Rawlins. Likewise, it compares Mosley and Chester Himess black detective heroes and highlight the trait...

  5. [Sir Arthur Conan Doyle, Sherlock Holmes and infectious diseases].

    Science.gov (United States)

    Ledermann D, Walter

    2010-10-01

    Besides a pleasant author of best sellers, Sir Arthur Conan Doyle was a medical doctor, writing excellent short stories about the exercise of his profession in England. However, even he mentions The British Medical Journal and The Lancet in the Sherlock Holmes's stories, when in the plot introduces infectious diseases, Conan Doyle ignores important discoveries in the field of tetanus. Anyway, the appearing of infectious diseases in the adventures of the detective are rare: one mention of tetanus, another of leprosy and- the most analyzed in medical literature a case of murder by inoculation of bacteria, probably the agent of melioidosis. Also he makes his hero discovers the toxic actions of a medusa and a transplant of solid organ. Little for a physician and less for an author who also wrote science fiction: it seems that the history of the great medical discoveries at the end of nineteenth century and beginning of the twentieth has passed by his side.., and he just couldn't see it.

  6. Italian Society of Rheumatology (SIR recommendations for performing arthrocentesis

    Directory of Open Access Journals (Sweden)

    A. Spadaro

    2011-09-01

    Full Text Available Joint fluid aspiration, or arthrocentesis, is one of the most useful and commonly performed procedures for the diagnosis and treatment of rheumatic diseases, but to date no definite guidelines have been published. For this reason, a group of experts of the Italian Society of Rheumatology (SIR produced evidence based recommendations for performing arthrocentesis. Among them, the most relevant are: a arthrocentesis is necessary when synovial effusion of unknown origin is present, especially if septic or crystal arthritis is suspected; b the patient should be clearly informed of the benefits and risks of the procedure in order to give an informed consent; c ultrasonography should be used to facilitate arthrocentesis in difficult joints; d fluid evacuation often has a therapeutic effect and facilitates the success of the following intraarticular injection; e careful skin disinfection and the use of sterile, disposable material is mandatory for avoiding septic complications. Disposable, non sterile gloves should always be used by the operator, mainly for his own protection; f contraindications are the presence of skin lesions or infections in the area of the puncture; g the patient’s anticoagulant treatment is not a contraindication, providing the therapeutic range is not exceeded; h joint rest after arthrocentesis is not indicated. Several of these recommendations were based on experts’ opinion rather than on published evidence which is scanty.

  7. Sir James Paget: Paget's disease of the nipple, Paget's disease of bone.

    Science.gov (United States)

    Ellis, Harold

    2013-04-01

    Sir James Paget was one of the 'great' Victorians. Eminent as a surgeon, pathologist and teacher, his nobility of character and application to his work made him a leader in his profession in that age of great men.

  8. SIR-A views our environment An Experiment in the Batu Angkal Area, West Kalimantan, Indonesia

    Directory of Open Access Journals (Sweden)

    Sutanto .

    2013-07-01

    Factors affecting the ease of identification are. mainly tonal contrast, shape, size, surface roughness, direction in relation to the illumination, and dielectric constant. Due to the future availability of SIR-B image of Kalimantan, further study is recommended.

  9. Identifying settlements on the SIR-B images of Rimbobujang and the surrounding areas, Sumatra, Indonesia

    Directory of Open Access Journals (Sweden)

    Sutanto .

    2013-07-01

    SIR-B image proves to be a reasonably good tool to identify rural settlement in an open area, especially for that with high density of houses. Its use to identify towns and cities is more recommended.

  10. SIR JOHN CRAWFORD MEMORIAL ADDRESS: Agriculture: The challenges of the 21st century

    OpenAIRE

    Beddington, Sir John

    2012-01-01

    The Sir John Crawford Memorial Address has been presented since 1985, in honour of the distinguished Australian civil servant, educator and agriculturalist in whose name the Crawford Fund was established. Sir John Crawford was a remarkable Australian who contributed at the highest levels, and was a passionate supporter of international agricultural research for development. This talk draws attention to four current and interrelated trends that suggest the world will be rather different by 202...

  11. Scientific objectives and selection of targets for the SMART-1 Infrared Spectrometer (SIR)

    Science.gov (United States)

    Basilevsky, A. T.; Keller, H. U.; Nathues, A.; Mall, U.; Hiesinger, H.; Rosiek, M.

    2004-12-01

    The European SMART-1 mission to the Moon, primarily a testbed for innovative technologies, was launched in September 2003 and will reach the Moon in 2005. On board are several scientific instruments, including the point-spectrometer SMART-1 Infrared Spectrometer (SIR). Taking into account the capabilities of the SMART-1 mission and the SIR instrument in particular, as well as the open questions in lunar science, a selection of targets for SIR observations has been compiled. SIR can address at least five topics: (1) Surface/regolith processes; (2) Lunar volcanism; (3) Lunar crust structure; (4) Search for spectral signatures of ices at the lunar poles; and (5) Ground truth and study of geometric effects on the spectral shape. For each topic we will discuss specific observation modes, necessary to achieve our scientific goals. The majority of SIR targets will be observed in the nadir-tracking mode. More than 100 targets, which require off-nadir pointing and off-nadir tracking, are planned. It is expected that results of SIR observations will significantly increase our understanding of the Moon. Since the exact arrival date and the orbital parameters of the SMART-1 spacecraft are not known yet, a more detailed planning of the scientific observations will follow in the near future.

  12. Occupational exposure following Yttrium-90 microspheres SIR therapy

    International Nuclear Information System (INIS)

    Fontaine, P.; Boirie, G.; Dieudonne, A.; Leguludec, D.; Lebtahi, R.; Ben Reguiga, M.

    2015-01-01

    Full text of publication follows. Introduction: Selective Internal Radiation Therapy (SIRT) is a promising technique for solid hepatic neoplasms treatment. SIRT consists in implanting radioactive microspheres (RMS) in targeted hepatic lesions via femoral artery. Two RMS-Therapsheres [glass-microspheres/TSR] and Sir-Spheres [resin-spheres/SSR]- are marketed in the European market, both radiolabeled with Yttrium-90. The objective of this study is to assess occupational exposure for nuclear medicine, radiology and clinical staff involved in Y 90 -RMS preparation and implantation. Materials and methods: The study was conducted on 20 patients treated for Hepato-Cellular Carcinoma: 10 treated with TSR and 10 with SSR. Dose rate (DR, mSv/h) or absorbed doses (mSv) measurements were made during all steps of TSR and SSR handling: sources receipt and unpacking, preparation, transport to radiology, implantation, and patient care. Measurements were made with portable ionization chamber(Babyline/Nardeux), spectrometer(FieldSpect/Aries), digital dosimeter (NED/Unfors) and operational dosimeter (Mk2/Siemens). Values were expressed as mean±SD. Results: patients received of 1.8 GBq to 3.1 GBq of TSR and 0.55 GBq to 2.4 GBq of SSR. TSR were delivered ready-to-use with the prescribed activity. For SSR only one activity was commercially available and shipped (3 GBq at calibration-time)requiring a preparation step to adjust needed activity. DR measured during RMS was 1723 ± 157 μSv/h SSR and 1189 ± 92 μSv/h for TSR. When preparing spheres in radiopharmacy, fingers and whole body doses were respectively 8326 ± 2360 μSv and 12.3 ± 5,2 μSv for Sir-Spheres vs. 33.5 ± 7.8 μSv and 1.1 ± 0.3 μSv for TSR. DR in contact with carrying case during RMS transfer to radiology were 299 ± 102 μSv/h for SSR and 5.3 ± 1.2 μSv/h for TSR. During RMS infusion, radiologist's finger doses were limited to 3.6 ± 1 μSv for SSR and 0.7± 0.3 μSv for TSR. Finally, following RMS

  13. New Processing of Spaceborne Imaging Radar-C (SIR-C) Data

    Science.gov (United States)

    Meyer, F. J.; Gracheva, V.; Arko, S. A.; Labelle-Hamer, A. L.

    2017-12-01

    The Spaceborne Imaging Radar-C (SIR-C) was a radar system, which successfully operated on two separate shuttle missions in April and October 1994. During these two missions, a total of 143 hours of radar data were recorded. SIR-C was the first multifrequency and polarimetric spaceborne radar system, operating in dual frequency (L- and C- band) and with quad-polarization. SIR-C had a variety of different operating modes, which are innovative even from today's point of view. Depending on the mode, it was possible to acquire data with different polarizations and carrier frequency combinations. Additionally, different swaths and bandwidths could be used during the data collection and it was possible to receive data with two antennas in the along-track direction.The United States Geological Survey (USGS) distributes the synthetic aperture radar (SAR) images as single-look complex (SLC) and multi-look complex (MLC) products. Unfortunately, since June 2005 the SIR-C processor has been inoperable and not repairable. All acquired SLC and MLC images were processed with a course resolution of 100 m with the goal of generating a quick look. These images are however not well suited for scientific analysis. Only a small percentage of the acquired data has been processed as full resolution SAR images and the unprocessed high resolution data cannot be processed any more at the moment.At the Alaska Satellite Facility (ASF) a new processor was developed to process binary SIR-C data to full resolution SAR images. ASF is planning to process the entire recoverable SIR-C archive to full resolution SLCs, MLCs and high resolution geocoded image products. ASF will make these products available to the science community through their existing data archiving and distribution system.The final paper will describe the new processor and analyze the challenges of reprocessing the SIR-C data.

  14. New Daily Persistent Headache: Historical Review and an Interview with Dr. Walter Vanast.

    Science.gov (United States)

    Robbins, Matthew S; Vanast, Walter J; Allan Purdy, R

    2017-06-01

    New daily persistent headache (NDPH) is an idiopathic headache syndrome characterized by the abrupt onset of an unremitting, daily, continuous headache without an antecedent escalating headache pattern, and not attributable to other primary or secondary headache disorders. We review the history of NDPH in terms of its characterization and classification, and then interview Dr. Walter Vanast, the neurologist who initially described NDPH three decades ago, to gain his perspective now that there is more widespread recognition and interest in this syndrome. © 2017 American Headache Society.

  15. The sons of Caim: the race of outcasts and disinherited in Walter Benjamin and Charles Baudelaire

    Directory of Open Access Journals (Sweden)

    Ricardo André Ferreira Martins

    2014-08-01

    Full Text Available This article aims to develop a reflection essay about the philosophical and literary representation concerning the marginalized and oppressed in history, inside the works of Charles Baudelaire and Walter Benjamin. This is to ascertain and analyze how these two authors, from their respective works, allowed the proletariat gradually took the shape of an object and productive character for social and lyrical reflection, thus, in the wake of works as Flowers of Evil, the assumption of themes drawn from a tradition historically long, connected, in turn, by the recent historiographical perspective from below.

  16. L’esperienza estetica come esperienza di immagini. Walter Benjamin e Theodor W. Adorno

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    Elena Tavani

    2012-05-01

    Full Text Available Both Walter Benjamin and Theodor W. Adorno consider ‘aesthetical experience’ as an “image experience” assuming a power of images “to set free forces” directed to produce or support aesthetical-political (Benjamin or aesthetical-critical (Adorno requirements. Profane illumination, ‘thinkimages’, phantasmagory, dialectical images, decayed ‘aura’ and technicalized images in Benjamin’s theory of aesthetical modernity. Expressive feature or “mimetic” eloquence in nature and art countering reality, dismantled ‘aura’ in contemporary desacralized work of art, but also persisting ‘aura’ in its meaningful dimension in Adorno’s aesthetical theory.

  17. Gothic elements in contemporary detective story : Matthew Gregory Lewis and Minette Walters compared

    Directory of Open Access Journals (Sweden)

    Vesna Marinko

    2009-12-01

    Full Text Available One of the most shocking Gothic novels was written by Matthew Gregory Lewis in 1796. His Gothic novel The Monk contains all the typical Gothic elements such as a ruined castle, aggressive villain, women in distress, the atmosphere of terror and horror and a lot more. This article analyses and compares to what extent the Gothic elements of the late 18th century survived in the contemporary detective story The Ice House (1993 written by Minette Walters and how these elements have changed.

  18. [Decriminalizing traditional Andean medicine: an interview with Walter Álvarez Quispe].

    Science.gov (United States)

    Quispe, Walter Álvarez; Loza, Carmen Beatriz

    2014-01-01

    Walter Álvarez Quispe, a Kallawaya healer and biomedical practitioner specializing in general surgery and gynecology, presents the struggle of traditional and alternative healers to get their Andean medical systems depenalized between 1960 and 1990. Bolivia was the first country in Latin America and the Caribbean to decriminalize traditional medicine before the proposals of the International Conference on Primary Health Care (Alma-Ata, 1978). The data provided by the interviewee show that the successes achieved, mainly by the Kallawayas, stem from their own independent initiative. These victories are not the result of official policies of interculturality in healthcare, although the successes achieved tend to be ascribed to them.

  19. Medicinas tradicionales andinas y su despenalización: entrevista con Walter Álvarez Quispe

    OpenAIRE

    Quispe, Walter Álvarez; Loza, Carmen Beatriz

    2014-01-01

    Walter Álvarez Quispe, terapeuta kallawaya y biomédico especializado en cirugía general y ginecología, presenta la lucha de los terapeutas tradicionales y alternativos por la depenalización de estos sistemas médicos andinos realizada entre 1960 y 1990. Bolivia se torna el primer país en América Latina y el Caribe en despenalizar la medicina tradicional antes de los planteamientos de la Conferencia Internacional sobre Atención Primaria de Salud (Alma-Ata, 1978). Los datos aportados por el entr...

  20. Verification of the linearity of the new SIR using sources of 64Cu and 99mTc

    International Nuclear Information System (INIS)

    Michotte, Carine

    2012-02-01

    The linearity of the new SIR electronics has been verified by looking for deviations from the exponential decay for several 64 Cu and 99m Tc sources. Data analyses are compared with the half-life used as a fixed or free parameter. It is concluded that no significant non-linearity is observed in the new SIR. For comparison, the same method has been applied to analyse existing data from the original SIR. (author)

  1. Serum inflammatory markers in the elderly: are they useful in differentiating sepsis from SIRS?

    Directory of Open Access Journals (Sweden)

    Mahshid Talebi-Taher

    2014-06-01

    Full Text Available Differentiating sepsis from other noninfectious causes of systemic inflammation is often difficult in the elderly. The aim of this study was to evaluate the ability of C-reactive protein (CRP, Erythrocyte Sedimentation Rate (ESR, procalcitonin (PCT, and Interleukin-6 (IL-6 to identify elderly patients with sepsis. In this single center prospective observational study, we included all consecutive elderly patients admitted with suspected sepsis and systemic inflammatory response syndrome (SIRS in an emergency department. Blood samples for measuring CRP, PCT, IL-6, ESR and white blood cells (WBC count were taken at first day of admission. Sensitivity, specificity, positive and negative predictive values were calculated for each inflammatory markers being studied. A total of 150 elderly patients aged 65 and older, 50 with sepsis and 50 with SIRS, and fifty individuals in a normal health status were included. CRP exhibited the greatest sensitivity (98% and negative predictive value (98.6% and performed best in differentiating patients with sepsis from those with SIRS. In a receiver operating characteristic curve analysis, IL-6 performed best in distinguishing between SIRS and the control group (AUC 0.75, 95% CI. On the other hand, both CRP and ESR appeared to be a more accurate diagnostic parameter for differentiating sepsis from SIRS among elderly patients.

  2. Constitutive Relation of Engineering Material Based on SIR Model and HAM

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    Haoxiang He

    2014-01-01

    Full Text Available As an epidemic mathematical model, the SIR model represents the transition of the Susceptible, Infected, and Recovered. The profound implication of the SIR model is viewed as the propagation and dynamic evolutionary process of the different internal components and the characteristics in a complex system subject to external effect. The uniaxial stress-strain curve of engineering material represents the basic constitutive relation, which also represents the damage propagation in the units of the damaged member. Hence, a novel dynamic stress-strain model is established based on the SIR model. The analytical solution and the approximate solution for the proposed model are represented according to the homotopy analysis method (HAM, and the relationship of the solution and the size effect and the strain rate is discussed. In addition, an experiment on the size effect of confined concrete is carried out and the solution of SIR model is suitable for simulation. The results show that the mechanical mechanism of the parameters of the uniaxial stress-strain model proposed in this paper reflects the actual characteristics of the materials. The solution of the SIR model can fully and accurately show the change of the mechanical performance and the influence of the size effect and the strain rate.

  3. SIRS score on admission and initial concentration of IL-6 as severe acute pancreatitis outcome predictors.

    Science.gov (United States)

    Gregoric, Pavle; Pavle, Gregoric; Sijacki, Ana; Ana, Sijacki; Stankovic, Sanja; Sanja, Stankovic; Radenkovic, Dejan; Dejan, Radenkovic; Ivancevic, Nenad; Nenad, Ivancevic; Karamarkovic, Aleksandar; Aleksandar, Karamarkovic; Popovic, Nada; Nada, Popovic; Karadzic, Borivoje; Borivoje, Karadzic; Stijak, Lazar; Stefanovic, Branislav; Branislav, Stefanovic; Milosevic, Zoran; Zoran, Milosević; Bajec, Djordje; Djordje, Bajec

    2010-01-01

    Early recognition of severe form of acute pancreatitis is important because these patients need more agressive diagnostic and therapeutical approach an can develope systemic complications such as: sepsis, coagulopathy, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Dysfunction Syndrome (MODS), Multiple Organ Failure (MOF). To determine role of the combination of Systemic Inflammatory Response Syndrome (SIRS) score and serum Interleukin-6 (IL-6) level on admission as predictor of illness severity and outcome of Severe Acute Pancreatitis (SAP). We evaluated 234 patients with first onset of SAP appears in last twenty four hours. A total of 77 (33%) patients died. SIRS score and serum IL-6 concentration were measured in first hour after admission. In 105 patients with SIRS score 3 and higher, initial measured IL-6 levels were significantly higher than in the group of remaining 129 patients (72 +/- 67 pg/mL, vs 18 +/- 15 pg/mL). All nonsurvivals were in the first group, with SIRS score 3 and 4 and initial IL-6 concentration 113 +/- 27 pg/mL. The values of C-reactive Protein (CRP) measured after 48h, Acute Physiology and Chronic Health Evaluation (APACHE II) score on admission and Ranson score showed the similar correlation, but serum amylase level did not correlate significantly with Ranson score, IL-6 concentration and APACHE II score. The combination of SIRS score on admission and IL-6 serum concentration can be early, predictor of illness severity and outcome in SAP.

  4. SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

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    Chi-Hsien Peng

    2010-06-01

    Full Text Available Retinal stem cells bear potency of proliferation, self-renewal, and differentiation into many retinal cells. Utilizing appropriate sensors one can effectively detect the self-renewal and aging process abilities. Silencing information regulator (SirT1, a member of the sirtuin family, is a NAD-dependent histone deacetylase and an essential mediator for longevity in normal cells by calorie restriction. We firstly investigate the SirT1 mRNA expression in retinal stem cells from rats and 19 human eyes of different ages. Results revealed that SirT1 expression was significantly decreased in in vivo aged eyes, associated with poor self-renewal abilities. Additionally, SirT1 mRNA levels were dose-dependently increased in resveratrol- treated retinal stem cells. The expression of SirT1 on oxidative stress-induced damage was significantly decreased, negatively correlated with the level of intracellular reactive oxygen species production. Treatment with resveratrol could effectively further reduce oxidative stress induced by H2O2 treatment in retinal stem cells. Importantly, the anti-oxidant effects of resveratrol in H2O2-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1. SirT1 expression provides a feasible sensor in assessing self-renewal and aging process in retinal stem cells. Resveratrol can prevent reactive oxygen species-induced damages via increased retinal SirT1 expression.

  5. Psychosurgery, ethics, and media: a history of Walter Freeman and the lobotomy.

    Science.gov (United States)

    Caruso, James P; Sheehan, Jason P

    2017-09-01

    At the peak of his career, Walter J. Freeman II was a celebrated physician and scientist. He served as the first chairman of the Department of Neurology at George Washington University and was a tireless advocate of surgical treatment for mental illness. His eccentric appearance, engaging personality during interviews, and theatrical demonstrations of his surgical techniques gained him substantial popularity with local and national media, and he performed more than 3000 prefrontal and transorbital lobotomies between 1930 and 1960. However, poor patient outcomes, unfavorable portrayals of the lobotomy in literature and film, and increased regulatory scrutiny contributed to the lobotomy's decline in popularity. The development of antipsychotic medications eventually relegated the lobotomy to rare circumstances, and Freeman's reputation deteriorated. Today, despite significant advancements in technique, oversight, and ethical scrutiny, neurosurgical treatment of mental illness still carries a degree of social stigma. This review presents a historical account of Walter Freeman's life and career, and the popularization of the lobotomy in the US. Additionally, the authors pay special attention to the influence of popular literature and film on the public's perception of psychosurgery. Aided by an understanding of this pivotal period in medical history, neurosurgeons are poised to confront the ethical and sociological questions facing psychosurgery as it continues to evolve.

  6. PROTAGONISMO DOS ÍNDIOS NORTE-AMERICANOS NOS DESENHOS ANIMADOS DE WALTER LANTZ

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    RAFAEL DUARTE OLIVEIRA VENANCIO

    2011-06-01

    Full Text Available Condemned to a dubious media representation in early cinema through thenovels of the late nineteenth century, the North American Indians never had a high profile infilms of this period. However, an animator, Walter Lantz, has a high degree of characterizationof Native Americans in his work. The aim of this paper is to study the role of Native Americansin these cartoons and analyze the social implications of these choices, using the concepts ofapparatus and formula. Furthermore, the analysis will include a portrayal of the Americanmedia scene before and after Lantz, seeking disruptions and legacies.Condenados a uma duvidosa representação midiática no início do cinema graçasaos romances do final do século XIX, os índios norte-americanos nunca tiveram um grandedestaque nos filmes dessa época. No entanto, um realizador de desenhos animados, WalterLantz, possui um alto grau de caracterização de nativos norte-americanos em seus trabalhos. Oobjetivo do presente artigo é estudar o protagonismo dos índios norte-americanos nessesdesenhos animados, e analisar as implicações sociais dessas escolhas através do uso dosconceitos de dispositivo e fórmula. Além disso, a análise incluirá a retratação da cenamidiática norte-americana antes e depois de Lantz, buscando rupturas e legados.

  7. STS-55 MS1/PLC Ross and Payload Specialist Walter work in SL-D2 module

    Science.gov (United States)

    1993-01-01

    STS-55 Mission Specialist 1 (MS1) and Payload Commander (PLC) Jerry L. Ross floats near cycle ergometer and Rack 9 Anthrorack (AR) (Human Physiology Laboratory) as German Payload Specialist 1 Ulrich Walter reviews a checklist in front of Rack 11 Experiment Rack. These experiment stations and the crewmembers are in the shirt-sleeve environment of the Spacelab Deutsche 2 (SL-D2) science module onboard the Earth-orbiting Columbia, Orbiter Vehicle (OV) 102. In the background is the SL-D2 aft end cone. Behind Ross and Walter is Rack 12 Experiment Rack with Baroreflex (BA).

  8. BOREAS RSS-15 SIR-C and Landsat TM Biomass and Landcover Maps of the NSA

    Science.gov (United States)

    Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Ranson, K. Jon

    2000-01-01

    As part of BOREAS, the RSS-15 team conducted an investigation using SIR-C, X-SAR, and Landsat TM data for estimating total above-ground dry biomass for the SSA and NSA modeling grids and component biomass for the SSA. Relationships of backscatter to total biomass and total biomass to foliage, branch, and bole biomass were used to estimate biomass density across the landscape. The procedure involved image classification with SAR and Landsat TM data and development of simple mapping techniques using combinations of SAR channels. For the SSA, the SIR-C data used were acquired on 06-Oct-1994, and the Landsat TM data used were acquired on 02-Sep-1995. The maps of the NSA were developed from SIR-C data acquired on 13-Apr-1994. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  9. Comparison of QSOFA score and SIRS criteria as screening mechanisms for emergency department sepsis.

    Science.gov (United States)

    Haydar, Samir; Spanier, Matthew; Weems, Patricia; Wood, Samantha; Strout, Tania

    2017-11-01

    The Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) score has been shown to accurately predict mortality in septic patients and is part of recently proposed diagnostic criteria for sepsis. We sought to ascertain the sensitive of the score in diagnosing sepsis, as well as the diagnostic timeliness of the score when compared to traditional systemic inflammatory response syndrome (SIRS) criteria in a population of emergency department (ED) patients treated in the ED, admitted, and subsequently discharged with a diagnosis of sepsis. Electronic health records of 200 patients who were treated for suspected sepsis in our ED and ultimately discharged from our hospital with a diagnosis of sepsis were randomly selected for review from a population of adult ED patients (N=1880). Data extracted included the presence of SIRS criteria and the qSOFA score as well as time required to meet said criteria. In this cohort, 94.5% met SIRS criteria while in the ED whereas only 58.3% met qSOFA. The mean time from arrival to SIRS documentation was 47.1min (95% CI: 36.5-57.8) compared to 84.0min (95% CI: 62.2-105.8) for qSOFA. The median ED "door" to positive SIRS criteria was 12min and 29min for qSOFA. Although qSOFA may be valuable in predicting sepsis-related mortality, it performed poorly as a screening tool for identifying sepsis in the ED. As the time to meet qSOFA criteria was significantly longer than for SIRS, relying on qSOFA alone may delay initiation of evidence-based interventions known to improve sepsis-related outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Delineation of major geologic structures in Turkey using SIR-B data

    Science.gov (United States)

    Toksoz, M. N.; Pettengill, G. H.; Ford, P.; Gulen, L.

    1984-01-01

    Shuttle Imaging Radar-B (SIR-B) images of well mapped segments of major faults, such as the North Anatolian Fault (NAF) and East Anatolian Fault (EAF) will be studied to identify the prominent signatures that characterize the fault zones for those specific regions. The information will be used to delineate the unmapped fault zones in areas with similar geological and geomorphological properties. The data obtained from SIR-B images will be compared and correlated with the LANDSAT thematic mapper and seismicity alignments based on well constrained earthquake epicenters.

  11. Richard J. Hill, Picturing Scotland through the Waverley Novels: Walter Scott and the Origins of the Victorian Illustrated Novel.

    Directory of Open Access Journals (Sweden)

    Jacqueline Irene Cannata

    2012-10-01

    Full Text Available Richard J. Hill, Picturing Scotland through the Waverley Novels: Walter Scott and the Origins of the Victorian Illustrated Novel . Farnham, Surrey, and Burlington, VT: Ashgate, 2010. Pp. 236. ISBN 978-0-7546-6806-0. US$99.99.

  12. A poética da tradução em Walter Benjamin e Haroldo de Campos

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    Luciene Guimarães de Oliveira

    2005-04-01

    Full Text Available Este ensaio visa traçar um paralelo entre a poética da tradução de Walter Benjamin, em “A Tarefa do Tradutor”, e a de Haroldo de Campos, poeta, tradutor, e crítico brasileiro em sua teoria da tradução.

  13. "Walter Gropius" by Dean Carter. Exhibition of College of Architecture and Urban Studies Timeline and Portrait Busts.

    OpenAIRE

    Carter, Dean

    2014-01-01

    DEAN CARTER. Walter Gropius. Cast bronze. The Art Collection / Virginia Tech Foundation Exhibition of portrait busts and the timeline of the history College of Architecture and Urban Studies, on the occasion of the 50th anniversary of the College. Curated by Truman Capone and Deb Sim. Francis T. Eck Exhibition Corridor, Moss Arts Center, Virginia Tech. Image 13

  14. Internal Quality Assurance Reviews: Challenges and Processes--Walter Sisulu University's Business, Management Sciences and Law Faculty

    Science.gov (United States)

    Moodly, A.; Saunderson, I.

    2008-01-01

    The Council for Higher Educations' (CHE) Higher Education Quality Committee (HEQC) requires internal quality evaluations to be performed on the various programmes offered by the Faculty before visitation by the HEQC. This article examines some of the challenges and processes followed by six of the departments of Walter Sisulu University's Faculty…

  15. Memória e história: Hannah Arendt em diálogo com Walter Benjamin

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    Magalhães, Marionilde Brepohl de

    2006-01-01

    Full Text Available A autora tem como proposta refletir sobre o papel da memória e da História em nossa cultura contemporânea, através de uma aproximação ao pensamento de Hannah Arendt e Walter Benjamin

  16. L´autobiografia e il desiderio: sulla trilogia di Walter Siti

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    Alberto Casadei

    2008-04-01

    Full Text Available Neste ensaio é examinada toda a produção do escritor e crítico Walter Siti. A análise é desenvolvida segundo dois eixos fundamentais de um lado a relação com a forma da autobiografia, que se torna aqui explicitamente "falsificada", pondo em discussão a relação entre ficção/não ficção; de outro a relação com a tradição literária, especialmente com o modelo dantesco, decisivo para uma leitura "alegórica" dos vários contos.

  17. Seasonal variation in secondary metabolites of edible shoots of Buck's beard [Aruncus dioicus (Walter) Fernald (Rosaceae)].

    Science.gov (United States)

    Fusani, Pietro; Piwowarski, Jakub P; Zidorn, Christian; Kiss, Anna K; Scartezzini, Fabrizio; Granica, Sebastian

    2016-07-01

    Aruncus dioicus (Walter) Fernald is an herbaceous plant belonging to the Rosaceae family. In the northern regions of Italy young shoots of A. dioicus are collected and used as vegetable. No studies on the chemical composition of young shoots of A. dioicus have been reported so far. Thus, the aim of the present paper was to develop and validate a comprehensive chromatographic method allowing the identification and quantification of chemical compounds occurring in A. dioicus shoots harvested at different developmental stages. The results showed that shoots contain mainly polyphenols. Twenty-four compounds were detected. Caffeoylglucose derivatives were recognized as major compounds. It was also confirmed that shoots contain the cyanogenic compound prunasin at all investigated vegetation stages. It was shown that the prunasin content significantly increases during plant development, thus justifying the belief that after the development of the first green leaves, shoots should not be used for culinary purposes any longer. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. W. Grey Walter, pioneer in the electroencephalogram, robotics, cybernetics, artificial intelligence.

    Science.gov (United States)

    Bladin, Peter F

    2006-02-01

    With the announcement by William Lennox at the 1935 London International Neurology Congress of the use of electroencephalography in the study of epilepsy, it became evident that a new and powerful technique for the investigation of seizures had been discovered. William Grey Walter, a young researcher finishing his post-graduate studies at Cambridge, was selected to construct and study the EEG in clinical neurology at the Maudsley Hospital, London. His hugely productive pioneering career in the use of EEG would eventually lead to groundbreaking work in other fields --the emerging sciences of robotics, cybernetics, and early work in artificial intelligence. In this historical note his pioneering work in the fields of clinical neurophysiology is documented, both in the areas of epileptology and tumour detection. His landmark contributions to clinical neurophysiology are worthy of documentation.

  19. Walter Miles, Pop Warner, B. C. Graves, and the psychology of football.

    Science.gov (United States)

    Baugh, Frank G; Benjamin, Ludy T

    2006-01-01

    In 1926-1927, a graduate student, B. C. Graves, working with Stanford University psychologist Walter Miles and legendary football coach Pop Warner, conducted an investigation of variations in signal calling as they affected the charging times of football players. The study was one of two that involved Miles and the ingenious multiple chronograph that he had invented to time the reactions of seven players simultaneously. These studies represented a brief digression in the career of Miles, who certainly was no sport psychologist. They tell of an interesting collaboration between scientist and coaches that produced one of the richest studies in sport psychology in the first half of the twentieth century. Copyright 2006 Wiley Periodicals, Inc.

  20. A TEMÁTICA DA INFÂNCIA SOB A VISÃO DE WALTER BENJAMIN

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    Aparecida Maria Sales de SOUZA

    2011-01-01

    Full Text Available Este texto tem como objetivo analisar as reflexões de Walter Benjamin relacionadas à temática da infância e demonstrar que as considerações do filósofo são relevantes para a sociedade contemporânea. Benjamin critica a pedagogia, dá ênfase à valorização da criança e vê o brincar como experiência formadora da infância plena e do adulto realizado. Através das proposições de Benjamin, pode-se ter outra visão sobre a experiência educacional da criança. A pesquisa é teórica confirmando o pensamento de Benjamin com outros autores em relação à criança, o brincar e à educação.

  1. Conference on Inequalities and Applications : Dedicated to the Memory of Wolfgang Walter

    CERN Document Server

    Gilányi, Attila; Losonczi, László; Plum, Michael

    2012-01-01

    Inequalities arise as an essential component in various mathematical areas. Besides forming a highly important collection of tools, e.g. for proving analytic or stochastic theorems or for deriving error estimates in numerical mathematics, they constitute a challenging research field of their own. Inequalities also appear directly in mathematical models for applications in science, engineering, and economics. This edited volume covers divers aspects of this fascinating field. It addresses classical inequalities related to means or to convexity as well as inequalities arising in the field of ordinary and partial differential equations, like Sobolev or Hardy-type inequalities, and inequalities occurring in geometrical contexts. Within the last five decades, the late Wolfgang Walter has made great contributions to the field of inequalities. His book on differential and integral inequalities was a real breakthrough in the 1970’s and has generated a vast variety of further research in this field. He also organize...

  2. Subjectivity and the “Shocking”: Walter Pater, Oscar Wilde and Ethical Limits of Pleasure

    Directory of Open Access Journals (Sweden)

    Ashmita Mukherjee

    2016-02-01

    Full Text Available The article analyzes the “shocking” and so-called “immoral” as a response to the institution-imposed methods of surveillance. This leads to initiation of discourses over behavior or actions which may not be unethical but which may be questionable in terms of social propriety. Moreover, the “shocking” may be seen as persistent attempts at formulation of subjectivity -the “performative self.” These ideas are analyzed with reference to Foucault's perspective on the issues and briefly in context of the late Victorian Aesthete culture spearheaded by Walter Pater and later, Oscar Wilde, the quintessential “dandy.” Their texts Marius the Epicurean and The Picture of Dorian Gray are read with the question of ethics and hedonism in mind, also relating the same to their fascination with classical Epicureanism.     Keywords: Aesthetics; Ethics; Pater; Wilde; Shocking; Surveillance; Foucault; Epicureanism.

  3. Stephen Hall Receives 2012 Walter Sullivan Award for Excellence in Science Journalism-Features: Citation

    Science.gov (United States)

    Pearson, Helen

    2013-01-01

    Stephen Hall, a freelance science writer and science-communication teacher, received the Walter Sullivan Award for Excellence in Science Journalism-Features at the AGU Fall Meeting Honors Ceremony, held on 5 December 2012 in San Francisco, Calif. Hall was honored for the article "At Fault?" published 15 September 2011 in Nature. The article examines the legal, personal, and political repercussions from a 2009 earthquake in L'Aquila, Italy for seismologists who had attempted to convey seismic risk assessments to the public. The 6.3 magnitude quake devastated the medieval town and caused more than 300 deaths. Six scientists and one government official were subsequently convicted of manslaughter and sentenced to prison for inadequately assessing and mischaracterizing the risks to city residents, despite the inexact nature of seismic risk assessment. The Sullivan award is for work published with a deadline pressure of more than 1 week.

  4. The implementation of research recommendations at the Walter Sisulu National Botanical Garden

    Directory of Open Access Journals (Sweden)

    Martie Mearns

    2009-09-01

    Full Text Available A comparative study Biodiversity is not a static phenomenon and many variables have an effect on accelerated biodiversity loss. While most of the variables affecting biodiversity loss are caused by humankind, many species are affected by more than one variable simultaneously. Six fundamental causes for biodiversity loss have been identifi ed, namely unsustainable population growth and associated increased pressure on natural resources; a reduced spectrum of agricultural, forestry and fishery products; failure of economic systems to attach appropriate economic value to the environment and resources; inequality in ownership, flow and management of the benefits and utilisation of resources; insufficient knowledge in the application and use of resources; and legislation and institutional systems that promote unsustainable abuse of the environment (Middleton 2003:250. The worldwide loss of biodiversity makes the management of protected areas more important than ever. Protected areas are under increasing pressure to become economically viable and independent of state grants. Tourism creates the mechanism and opportunities for protected areas to increase their economic viability while advancing the appreciation of nature. The management of these protected areas therefore includes the management of visitors. South Africa is the third most bio diverse country in the world. Amongst a variety of nature conservation endeavours nine national botanical gardens are managed by the South African National Biodiversity Institute (SANBI. One of the nine national gardens is the Walter Sisulu National Botanical Garden situated in Roodekrans towards the west of Johannesburg. A study was launched to determine preferences of visitors to the Walter Sisulu National Botanical Garden by making use of semi-structured interviews. The purpose of the study was threefold. Firstly the study was launched to determine whether visitors to the garden had an increased awareness

  5. Rayleigh-Taylor instability of two superposed conducting Walters B' elastico-viscous fluids in hydromagnetics

    International Nuclear Information System (INIS)

    Sharma, R.C.; Kumar, Pardeep

    1998-01-01

    The Rayleigh-Taylor instability of two superposed electrically conducting Walters elastico-viscous fluids (Model B') of uniform densities when the whole system is immersed in a uniform horizontal magnetic field has been studied. The stability analysis has been carried out, for mathematical simplicity, for two highly viscoelastic fluids of equal kinematic viscosities and equal kinematic viscoelasticities. For the stable configuration as in hydrodynamic case, the system is found to be stable or unstable for the wave-number range k (2v') -12 depending on kinematic viscoelasticity v'. For the unstable configuration, the magnetic field has got stabilizing effect and completely stabilizes certain wave-number range which was always unstable in the absence of magnetic field. The behaviour of growth rates with respect kinematic viscosity and kinematic viscoelasticity parameters are examined analytically. (author)

  6. Universos ficcionais: o romanesco em Walter Scott e José de Alencar

    Directory of Open Access Journals (Sweden)

    Marcos Roberto Flamínio Peres

    2016-10-01

    Full Text Available Tamanha é a força do romanesco em Walter Scott que ele foi capaz de dar origem a duas linhas de força críticas antagônicas: uma tendendo a situá-lo dentro do conjunto da literatura ocidental, reatualizando arquétipos ancestrais (Frye; outra considerando-o a quintessência do romance histórico por representar momentos cruciais por que passava a sociedade capitalista entre os séculos XVIII e XIX (Lukács. À luz desse pano de fundo teórico contrastivo, este artigo busca analisar Waverley (1814, obra mais influente de Scott, em comparação com As minas de prata (1865-1866, romance mais ambicioso de José de Alencar e que lança mão de estratégias narrativas similares.

  7. Furio Jesi’s mythological machine and the quote to Walter Benjamin

    Directory of Open Access Journals (Sweden)

    Mercedes Ruvitoso

    2014-12-01

    Full Text Available In his cognitive model called “mithological machine”, Furio Jesi proposes to circumscribe the concept of “myth” by means of a technique of critical composition of data and doctrines about the myth and the mythology. The model not only seeks to brave scientific-methodological reasons but also ethical-political ones. It’s about avoiding all the evocation and instrumentalization of myth in view of a political interest. This work analyzes the way as the model of Jesi resumes and develops two motives of Walter Benjamin’s work: (1 the one known as method of the quote without quotation marks and (2 the criticism of the reactionary theories of myth, specifically regarding the rehabilita­tion of Bachofen in the German culture from 1920’s and 1930’s.

  8. Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination

    OpenAIRE

    Miao, Anqi; Zhang, Jian; Zhang, Tongqian; Pradeep, B. G. Sampath Aruna

    2017-01-01

    A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control.

  9. The Threshold of a Stochastic SIRS Model with Vertical Transmission and Saturated Incidence

    Directory of Open Access Journals (Sweden)

    Chunjuan Zhu

    2017-01-01

    Full Text Available The threshold of a stochastic SIRS model with vertical transmission and saturated incidence is investigated. If the noise is small, it is shown that the threshold of the stochastic system determines the extinction and persistence of the epidemic. In addition, we find that if the noise is large, the epidemic still prevails. Finally, numerical simulations are given to illustrate the results.

  10. Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination

    Directory of Open Access Journals (Sweden)

    Anqi Miao

    2017-01-01

    Full Text Available A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control.

  11. Lyapunov functions and global stability for SIR and SEIR models with age-dependent susceptibility

    KAUST Repository

    Korobeinikov, Andrei; Melnik, Andrey V.

    2013-01-01

    We consider global asymptotic properties for the SIR and SEIR age structured models for infectious diseases where the susceptibility depends on the age. Using the direct Lyapunov method with Volterra type Lyapunov functions, we establish conditions for the global stability of a unique endemic steady state and the infection-free steady state.

  12. A Possible Source For Sir Thomas More’s ‘Mountainish Inhumanity’

    NARCIS (Netherlands)

    Steenbergh, Kristine

    2017-01-01

    Shakespeare’s authorship of a scene in Sir Thomas More has been established as highly probable on the basis of an analysis of the handwriting, vocabulary, and collocations stylistics. His addition to the play was long believed to have been written soon after publication of the original play, in

  13. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

    DEFF Research Database (Denmark)

    Lombard, David B; Alt, Frederick W; Cheng, Hwei-Ling

    2007-01-01

    Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here, we investigate the localization and function of SIRT3 in vivo. We show that endogenous mouse SIRT3 is a solubl...

  14. Application of Homotopy Perturbation and Variational Iteration Methods to SIR Epidemic Model

    DEFF Research Database (Denmark)

    Ghotbi, Abdoul R.; Barari, Amin; Omidvar, M.

    2011-01-01

    effective strategy against childhood diseases, the development of the framework that would predict the optimal vaccine coverage level needed to prevent the spread of diseases is crucial. The SIR model is a standard compartmental model that has been used to describe many epidemiological diseases...

  15. 90Sr content in 90Y-labeled SIR-spheres and Zevalin.

    Science.gov (United States)

    Metyko, John; Erwin, William; Poston, John; Jimenez, Sandra

    2014-11-01

    Three different 90Y internally administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures atMD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize 90Y-labeled microspheres, while Zevalin is an 90Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from 90Y production methods. The 90Y in SIR-Spheres and Zevalin are produced from a 90Sr/90Y generator, which leaves measurable quantities of 90Sr in the final product. TheraSphere 90Y is produced in a nuclear reactor which results in a large number of impurities, most notably 88Y and 91Y. Product information sheets reference these impurities with specific limits given. These limits represent a tiny fraction of the total product activity, and in the case of TheraSphere and SIR-Spheres gamma-emitting impurities, this has been verified in the literature. An analysis of 90Sr impurities in SIR-Spheres and Zevalin is presented in this paper. Impurity quantities were found to be within the vendors’ documented limits.

  16. Walter Reed Army Medical Center's Internet-based electronic health portal.

    Science.gov (United States)

    Abbott, Kevin C; Boocks, Carl E; Sun, Zhengyi; Boal, Thomas R; Poropatich, Ronald K

    2003-12-01

    Use of the World Wide Web (WWW) and electronic media to facilitate medical care has been the subject of many reports in the popular press. However, few reports have documented the results of implementing electronic health portals for essential medical tasks, such as prescription refills and appointments. At Walter Reed Army Medical Center, "Search & Learn" medical information, Internet-based prescription refills and patient appointments were established in January 2001. A multiphase retrospective analysis was conducted to determine the use of the "Search & Learn" medical information and the relative number of prescription refills and appointments conducted via the WWW compared with conventional methods. From January 2001 to May 2002, there were 34,741 refills and 819 appointments made over the Internet compared with 2,275,112 refills and approximately 500,000 appointments made conventionally. WWW activity accounted for 1.52% of refills and 0.16% of appointments. There was a steady increase in this percentage over the time of the analysis. In April of 2002, the monthly average of online refills had risen to 4.57% and online appointments were at 0.27%. Online refills were projected to account for 10% of all prescriptions in 2 years. The "Search & Learn" medical information portion of our web site received 147,429 unique visits during this same time frame, which was an average of 326 visitors per day. WWW-based methods of conducting essential medical tasks accounted for a small but rapidly increasing percentage of total activity at Walter Reed Army Medical Center. Subsequent phases of analysis will assess demographic and geographic factors and aid in the design of future systems to increase use of the Internet-based systems.

  17. C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.

    Science.gov (United States)

    Chiang, Wei-Chung; Tishkoff, Daniel X; Yang, Bo; Wilson-Grady, Joshua; Yu, Xiaokun; Mazer, Travis; Eckersdorff, Mark; Gygi, Steven P; Lombard, David B; Hsu, Ao-Lin

    2012-09-01

    FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4--homolog of mammalian SIRT6 and SIRT7 proteins--promotes DAF-16-dependent transcription and stress-induced DAF-16 nuclear localization. SIR-2.4 is required for resistance to multiple stressors: heat shock, oxidative insult, and proteotoxicity. By contrast, SIR-2.4 is largely dispensable for DAF-16 nuclear localization and function in response to reduced insulin/IGF-1-like signaling. Although acetylation is known to regulate localization and activity of mammalian FoxO proteins, this modification has not been previously described on DAF-16. We find that DAF-16 is hyperacetylated in sir-2.4 mutants. Conversely, DAF-16 is acetylated by the acetyltransferase CBP-1, and DAF-16 is hypoacetylated and constitutively nuclear in response to cbp-1 inhibition. Surprisingly, a SIR-2.4 catalytic mutant efficiently rescues the DAF-16 localization defect in sir-2.4 null animals. Acetylation of DAF-16 by CBP-1 in vitro is inhibited by either wild-type or mutant SIR-2.4, suggesting that SIR-2.4 regulates DAF-16 acetylation indirectly, by preventing CBP-1-mediated acetylation under stress conditions. Taken together, our results identify SIR-2.4 as a critical regulator of DAF-16 specifically in the context of stress responses. Furthermore, they reveal a novel role for acetylation, modulated by the antagonistic activities of CBP-1 and SIR-2.4, in modulating DAF-16 localization and function.

  18. SIRS Digues 2.0: A Cooperative Software For Levees Management

    Directory of Open Access Journals (Sweden)

    Moins Isabelle

    2016-01-01

    Full Text Available SIRS Digues is a computing tool that makes informations on levees more durable and accessible in order to enhance their management. The first version of the software, which was IRSTEA’s initiative, was deployed in 2004. The second version was released in 2015. This article aims at pointing out the innovative aspects of this last version. They concern thematic and functionalities, computing technics and architecture, and last but not least, the business model chosen in order to build a long lasting software. The software’s kernel is sketched to propose a general description of levees: it focuses on description of the levees and linked objects, on disorders that affects them, on works... Most of these topics were already broached by the first version. The kernel of the version 2 may be extended using optional thematic modules. These modules concern: vegetation monitoring, reporting (in coherence with current French regulatory requirements, riverbanks, riverbed... Main functionnalities perfomed by SIRS Digues V1 and V2 are : data structuring and centralisation, quick access to relevant data, reporting and mapping, etc. SIRS Digues 2.0 updates and improves already existing functionalities of the first version. SIRS Digues V2 relies on an documentoriented NoSQL database, CouchDB, and on geospatial libraries, Geotoolkit and Apache-SIS. SIRS Digues V2 was released with a copyleft license. Copyrights belong to the French levees managers’ society, “France Digues”, which acts as a cooperative. Members put their heads together in order to gather their financial capacities and fund software development. France Digues has got the technical and thematic expertise and supply various services to the members. This business model aims to ensure accessibility, durability and adaptability of the software.

  19. SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells

    International Nuclear Information System (INIS)

    Xie Yuexia; Zhang Jianghong; Shao Chunlin; Xu Yanwu

    2012-01-01

    Intratumoral hypoxia is an important contributory factor to tumor cell resistance to radiotherapy. SirT1, a nicotinamide adenine dinucleotide (NAD + )-dependent histone/protein deacetylase, has been linked to the decrease of radiation-induced DNA damage and seems to be critical for cancer therapy. The purpose of this study was to investigate the role of SirT1 in hypoxia-induced radiation response on hepatoma cells. It was found that the administration with resveratrol, a putative SirT1 activator, enhanced the resistance of HepG2 cells against radiation-induced DNA damage of MN formation under hypoxia condition; while nicotinamide, a well-known SirT1 inhibitor, sensitized this radiation damage. Nevertheless, pretreatment of cells with 10058-F4, a specific inhibitor of c-Myc, almost eliminated the nicotinamide-induced radiosensitive effect. Further studies revealed that resveratrol inhibited c-Myc protein accumulation via up-regulation of SirT1 expression and deacetylase activity, and this loss of c-Myc protein was abolished by inhibiting its degradation in the presence of MG132, a potent inhibitor of proteasome. In contrast, nicotinamide attenuated c-Myc protein degradation induced by radiation under hypoxia through inhibition of SirT1 deacetylase activity. Our findings suggest that SirT1 could serve as a novel potent target of radiation-induced DNA damage and thus as a potential strategy to advance the efficiency of radiation therapy in hepatoma entities. (author)

  20. Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions

    Directory of Open Access Journals (Sweden)

    Christian eLinke

    2013-07-01

    Full Text Available The Forkhead box family of transcription factors is evolutionary conserved from yeast to higher eukaryotes and its members are involved in many physiological processes including metabolism, DNA repair, cell cycle, stress resistance, apoptosis and aging. In budding yeast, four Forkhead transcription factors were identified, namely Fkh1, Fkh2, Fhl1, and Hcm1, which are implicated in chromatin silencing, cell cycle regulation and stress response. These factors impinge transcriptional regulation during cell cycle progression, and histone deacetylases play an essential role in this process, e.g. the nuclear localisation of Hcm1 depends on Sir2 activity, whereas Sin3/Rpd3 silence cell cycle specific gene transcription in G2/M phase. However, a direct involvement of Sir2 in Fkh1/Fkh2-dependent regulation of target genes is at present unknown. Here, we show that Fkh1 and Fkh2 associate with Sir2 in G1 and M phase, and that Fkh1/Fkh2-mediated activation of reporter genes is antagonized by Sir2. We further report that Sir2 overexpression strongly affects cell growth in an Fkh1/Fkh2-dependent manner. In addition, Sir2 regulates the expression of the mitotic cyclin Clb2 through Fkh1/Fkh2-mediated binding to the CLB2 promoter in G1 and M phase. We finally demonstrate that Sir2 is also enriched at the CLB2 promoter under stress conditions, and that the nuclear localization of Sir2 is dependent on Fkh1 and Fkh2. Taken together, our results show a functional interplay between Fkh1/Fkh2 and Sir2 suggesting a novel mechanism of cell cycle repression. Thus, in budding yeast, not only the regulation of G2/M gene expression but also the protective response against stress could be directly coordinated by Fkh1 and Fkh2.

  1. [Walter Leitsch. Sigismund III. von Polen und Jan Zamoysky : die Rolle Estlands in der Rivalität zwischen König und Hetman] / Martin Faber

    Index Scriptorium Estoniae

    Faber, Martin

    2009-01-01

    Arvustus: Leitsch, Walter. Sigismund III. von Polen und Jan Zamoysky : die Rolle Estlands in der Rivalität zwischen König und Hetman. Wien : Verlag der Österreichischen Akademie der Wissenschaften, 2006

  2. Business Case Analysis of the Walter Reed Army Medical Center Medical/Surgical Prime Vendor Generation III Service Level Electron Program

    National Research Council Canada - National Science Library

    Markot, Peter B

    2007-01-01

    ...) staffing and medical/surgical services offered under the Prime Vendor (PV) Generation III contract would provide the best supply chain management solution for Walter Reed Army Medical Center (WRAMC...

  3. Hydromagnetic thermosolutal instability of compressible walters' (model B' rotating fluid permeated with suspended particles in porous medium

    Directory of Open Access Journals (Sweden)

    G Rana

    2016-09-01

    Full Text Available The thermosolutal instability of compressible Walters' (model B' elastico-viscous rotating fluid permeated with suspended particles (fine dust in the presence of vertical magnetic field in porous medium is considered. By applying normal mode analysis method, the dispersion relation has been derived and solved analytically. It is observed that the rotation, magnetic field, suspended particles and viscoelasticity introduce oscillatory modes. For stationary convection the Walters' (model B' fluid behaves like an ordinary Newtonian fluid and it is observed that the rotation and stable solute gradient has stabilizing effects and suspended particles are found to have destabilizing effect on the system, whereas the medium permeability has stabilizing or destabilizing effect on the system under certain conditions. The magnetic field has destabilizing effect in the absence of rotation, whereas in the presence of rotation, magnetic field has stabilizing or destabilizing effect under certain conditions.

  4. Le continent noir du désir masculin : Colet et Flaubert, encore

    OpenAIRE

    Vinken, Barbara

    2010-01-01

    Il y a peu d’échanges de lettres qui surprennent le lecteur aussi douloureusement que celui entre Louise Colet et Gustave Flaubert. Rarement, l’espoir qui sommeille au fond de tout lecteur d’une histoire d’amour heureux fut à ce point frustré.Les études de Freud – un des plus grands sceptiques en matière d’amour – sur la vie sexuelle éclairent les vicissitudes du désir amoureux masculin. Les Lettres de Flaubert à Colet sont la mise en scène dramatique d’un désir qui suit les complications du ...

  5. Determination of the Geographical Origin of All Commercial Hake Species by Stable Isotope Ratio (SIR) Analysis.

    Science.gov (United States)

    Carrera, Mónica; Gallardo, José M

    2017-02-08

    The determination of the geographical origin of food products is relevant to comply with the legal regulations of traceability, to avoid food fraud, and to guarantee food quality and safety to the consumers. For these reasons, stable isotope ratio (SIR) analysis using an isotope ratio mass spectrometry (IRMS) instrument is one of the most useful techniques for evaluating food traceability and authenticity. The present study was aimed to determine, for the first time, the geographical origin for all commercial fish species belonging to the Merlucciidae family using SIR analysis of carbon (δ 13 C) and nitrogen (δ 15 N). The specific results enabled their clear classification according to the FAO (Food and Agriculture Organization of the United Nations) fishing areas, latitude, and geographical origin in the following six different clusters: European, North African, South African, North American, South American, and Australian hake species.

  6. Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.

    Science.gov (United States)

    Ondracek, Caitlin R; Frappier, Vincent; Ringel, Alison E; Wolberger, Cynthia; Guarente, Leonard

    2017-03-07

    Sirtuin enzymes depend on NAD + to catalyze protein deacetylation. Therefore, the lowering of NAD + during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic screen to identify two mutations in the catalytic domain of yeast Sir2 that allow the enzyme to function in an NAD + -depleted environment. These mutant enzymes give rise to a significant increase of yeast replicative lifespan and increase deacetylation by the Sir2 ortholog, SIRT1, in mammalian cells. Our data suggest that these mutations increase the stability of the conserved catalytic sirtuin domain, thereby increasing the catalytic efficiency of the mutant enzymes. Our approach to identifying sirtuin mutants that permit function in NAD + -limited environments may inform the design of small molecules that can maintain sirtuin activity in aging organisms. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  7. Sir Peter Medawar: science, creativity and the popularization of Karl Popper

    Science.gov (United States)

    Calver, Neil

    2013-01-01

    Sir Peter Medawar was respected by scientists and literati alike. It was perhaps not surprising, then, that he would choose to involve himself in the ‘two cultures’ debate of 1959 and beyond. The focus of his intervention was the philosophy of Sir Karl Popper. However, Medawar's Popper was not the guru of falsification familiar from philosophy textbooks. Medawar's distinctive interpretation of Popper treated him instead as the source of insights into the role of creativity and imagination in scientific inquiry. This paper traces the context for Medawar's adoption of Popperian philosophy, together with its application before the debate. It then examines, within the context of the debate itself, the way in which Medawar attempted to reconcile scientific inquiry with literary practice. Medawar became increasingly convinced that not only was induction epistemologically unsound, but it was also damaging to the public role of the scientist. His construction of Popperianism would, he envisaged, provide a worthy alternative for scientists’ self-image.

  8. Strain analysis of I-c(epsilon) characteristic of YBCO coated conductor measured by a Walters spring

    OpenAIRE

    Sugano, M; Choi, S; Miyazoe, A; Miyamatsu, K; Ando, T; Itoh, K; Kiyoshi, T; Wada, H; Selvamanickam, V

    2008-01-01

    lc-strain characteristic of YBCO coated conductor was measured using a Walters spring (WASP). In this technique, additional bending and thermal strains induced to the YBCO layer should be considered. In order to produce different initial bending strain to the YBCO layer, the conductor was wound around the springs with different diameters and in the different bending directions. The clear evidence was obtained that -strain curves using a WASP strongly depend on the initial bending strain state...

  9. The threshold of a stochastic delayed SIR epidemic model with temporary immunity

    Science.gov (United States)

    Liu, Qun; Chen, Qingmei; Jiang, Daqing

    2016-05-01

    This paper is concerned with the asymptotic properties of a stochastic delayed SIR epidemic model with temporary immunity. Sufficient conditions for extinction and persistence in the mean of the epidemic are established. The threshold between persistence in the mean and extinction of the epidemic is obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number R0 of the deterministic system.

  10. Traveling waves in a delayed SIR model with nonlocal dispersal and nonlinear incidence

    Science.gov (United States)

    Zhang, Shou-Peng; Yang, Yun-Rui; Zhou, Yong-Hui

    2018-01-01

    This paper is concerned with traveling waves of a delayed SIR model with nonlocal dispersal and a general nonlinear incidence. The existence and nonexistence of traveling waves of the system are established respectively by Schauder's fixed point theorem and two-sided Laplace transform. It is also shown that the spread speed c is influenced by the dispersal rate of the infected individuals and the delay τ.

  11. Global analysis of multi-strains SIS, SIR and MSIR epidemic models

    OpenAIRE

    Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier

    2014-01-01

    International audience; We consider SIS, SIR and MSIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maxim...

  12. Competitive exclusion principle for SIS and SIR models with n strains

    OpenAIRE

    Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier

    2012-01-01

    We consider SIS and SIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maximum of each individual basic re...

  13. Design of power controller in CDMA system with power and SIR error minimization

    Institute of Scientific and Technical Information of China (English)

    Shulan KONG; Huanshui ZHANG; Zhaosheng ZHANG; Hongxia WANG

    2007-01-01

    In this paper, an uplink power control problem is considered for code division multiple access (CDMA) systems. A distributed algorithm is proposed based on linear quadratic optimal control theory. The proposed scheme minimizes the sum of the power and the error of signal-to-interference ratio (SIR). A power controller is designed by constructing an optimization problem of a stochastic linear quadratic type in Krein space and solving a Kalman filter problem.

  14. Analysis of Active Lava Flows on Kilauea Volcano, Hawaii, Using SIR-C Radar Correlation Measurements

    Science.gov (United States)

    Zebker, H. A.; Rosen, P.; Hensley, S.; Mouginis-Mark, P. J.

    1995-01-01

    Precise eruption rates of active pahoehoe lava flows on Kilauea volcano, Hawaii, have been determined using spaceborne radar data acquired by the Space Shuttle Imaging Radar-C (SIR-C). Measurement of the rate of lava flow advance, and the determination of the volume of new material erupted in a given period of time, are among the most important observations that can be made when studying a volcano.

  15. Dynamic Behavior for an SIRS Model with Nonlinear Incidence Rate and Treatment

    Directory of Open Access Journals (Sweden)

    Junhong Li

    2013-01-01

    Full Text Available This paper considers an SIRS model with nonlinear incidence rate and treatment. It is assumed that susceptible and infectious individuals have constant immigration rates. We investigate the existence of equilibrium and prove the global asymptotical stable results of the endemic equilibrium. We then obtained that the model undergoes a Hopf bifurcation and existences a limit cycle. Some numerical simulations are given to illustrate the analytical results.

  16. Thermal vacuum test of space equipment: tests of SIR-2 instrument Chandrayaan-1 mission

    Science.gov (United States)

    Sitek, P.

    2008-11-01

    We describe the reasons of proceeding Thermal-Vacuum tests for space electronic. We will answer on following questions: why teams are doing TV tests, what kind of phases should be simulated, which situations are the most critical during TV tests, what kind of results should be expected, which errors can be detect. As an example, will be shown TV-test of SIR-2 instrument for Chandrayaan-1 moon mission.

  17. Milestones in plant sulfur research on sulfur-induced-resistance (SIR in Europe

    Directory of Open Access Journals (Sweden)

    Elke eBloem

    2015-01-01

    Full Text Available Until the 1970´s of the last century sulfur (S was mainly regarded as a pollutant being the main contributor of acid rain, causing forest dieback in central Europe. When Clean Air Acts came into force at the start of the 1980´s SO2 contaminations in the air were consequently reduced within the next years. S changed from an unwanted pollutant into a lacking plant nutrient in agriculture since agricultural fields were no longer fertilized indirectly by industrial pollution. S deficiency was first noticed in Brassica crops that display an especially high S demand because of its content of S-containing secondary metabolites, the glucosinolates. In Scotland, where S depositions decreased even faster than in continental Europe, an increasing disease incidence with Pyrenopeziza brassicae was observed in oilseed rape in the beginning 1990´s and the concept of sulfur-induced-resistance (SIR was developed after a relationship between the S status and the disease incidence was uncovered. Since then a lot of research was carried out to unravel the background of SIR in the metabolism of agricultural crops and to identify metabolites, enzymes and reactions, which are potentially activated by the S metabolism to combat fungal pathogens. The S status of the crop is affecting many different plant features such as color and scent of flowers, pigments in leaves, metabolite concentrations and the release of gaseous S compounds which are directly influencing the desirability of a crop for a variety of different organisms from microorganisms, over insects and slugs to the point of grazing animals.The present paper is an attempt to sum up the knowledge about the effect of the S nutritional status of agricultural crops on parameters that are directly related to their health status and by this to SIR. Milestones in SIR research are compiled, open questions are addressed and future projections were developed.

  18. Montaigne, Sir Ralph Bankes and other English readers of the Essais.

    OpenAIRE

    O'Brien, John

    2013-01-01

    This article deals with a hitherto unknown and unpublished early modern English manuscript account of Montaigne's Essais by Sir Ralph Bankes (1631?–77) of Kingston Lacy in Dorset. Bankes's account covers a range of features in Montaigne's work: crucial elements of self-portraiture such as judgement, but also his attitude to women and doctors. These characteristics are analysed and compared first with Montaigne's own pronouncements about the aspects Bankes selects and secondly with two other s...

  19. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    Energy Technology Data Exchange (ETDEWEB)

    Samat, N. A.; Ma' arof, S. H. Mohd Imam [Department of Mathematics, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjung Malim, Perak (Malaysia)

    2014-12-04

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

  20. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    International Nuclear Information System (INIS)

    Samat, N. A.; Ma'arof, S. H. Mohd Imam

    2014-01-01

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases

  1. Simulation of emotional contagion using modified SIR model: A cellular automaton approach

    Science.gov (United States)

    Fu, Libi; Song, Weiguo; Lv, Wei; Lo, Siuming

    2014-07-01

    Emotion plays an important role in the decision-making of individuals in some emergency situations. The contagion of emotion may induce either normal or abnormal consolidated crowd behavior. This paper aims to simulate the dynamics of emotional contagion among crowds by modifying the epidemiological SIR model to a cellular automaton approach. This new cellular automaton model, entitled the “CA-SIRS model”, captures the dynamic process ‘susceptible-infected-recovered-susceptible', which is based on SIRS contagion in epidemiological theory. Moreover, in this new model, the process is integrated with individual movement. The simulation results of this model show that multiple waves and dynamical stability around a mean value will appear during emotion spreading. It was found that the proportion of initial infected individuals had little influence on the final stable proportion of infected population in a given system, and that infection frequency increased with an increase in the average crowd density. Our results further suggest that individual movement accelerates the spread speed of emotion and increases the stable proportion of infected population. Furthermore, decreasing the duration of an infection and the probability of reinfection can markedly reduce the number of infected individuals. It is hoped that this study will be helpful in crowd management and evacuation organization.

  2. Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging.

    Science.gov (United States)

    Orlandi, Ivan; Pellegrino Coppola, Damiano; Strippoli, Maurizio; Ronzulli, Rossella; Vai, Marina

    2017-01-01

    Nicotinamide (NAM), a form of vitamin B 3 , is a byproduct and noncompetitive inhibitor of the deacetylation reaction catalyzed by Sirtuins. These represent a family of evolutionarily conserved NAD + -dependent deacetylases that are well-known critical regulators of metabolism and aging and whose founding member is Sir2 of Saccharomyces cerevisiae. Here, we investigated the effects of NAM supplementation in the context of yeast chronological aging, the established model for studying aging of postmitotic quiescent mammalian cells. Our data show that NAM supplementation at the diauxic shift results in a phenocopy of chronologically aging sir2Δ cells. In fact, NAM-supplemented cells display the same chronological lifespan extension both in expired medium and extreme Calorie Restriction. Furthermore, NAM allows the cells to push their metabolism toward the same outcomes of sir2Δ cells by elevating the level of the acetylated Pck1. Both these cells have the same metabolic changes that concern not only anabolic pathways such as an increased gluconeogenesis but also respiratory activity in terms both of respiratory rate and state of respiration. In particular, they have a higher respiratory reserve capacity and a lower non-phosphorylating respiration that in concert with a low burden of superoxide anions can affect positively chronological aging. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  3. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

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    Samat, N. A.; Ma'arof, S. H. Mohd Imam

    2014-12-01

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

  4. Analysis of data acquired by Shuttle Imaging Radar SIR-A and Landsat Thematic Mapper over Baldwin County, Alabama

    Science.gov (United States)

    Wu, S.-T.

    1985-01-01

    Seasonally compatible data collected by SIR-A and by Landsat 4 TM over the lower coastal plain in Alabama were coregistered, forming a SIR-A/TM multichannel data set with 30 m x 30 m pixel size. Spectral signature plots and histogram analysis of the data were used to observe data characteristics. Radar returns from pine forest classes correlated highly with the tree ages, suggesting the potential utility of microwave remote sensing for forest biomass estimation. As compared with the TM-only data set, the use of SIR-A/TM data set improved classification accuracy of the seven land cover types studied. In addition, the SIR-A/TM classified data support previous finding by Engheta and Elachi (1982) that microwave data appear to be correlated with differing bottomland hardwood forest vegetation as associated with varying water regimens (i.e., wet versus dry).

  5. The utopian challenge to global capitalism by Walter van den Broeck in Terug naar Walden

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    Andries Visagie

    2012-12-01

    Full Text Available The socialist sympathies that inform the writing of Flemish author Walter van den Broeck align him with a well-established tradition of socially engaged writing in Flanders. In his novel Terug naar Walden (Back to Walden, published in 2009, he revisits the Walden project of the Dutch reformer and writer Frederik van Eeden (1860−1932. Van den Broeck suggests that a reconsideration of the socialist ideals that inspired Van Eeden to establish settlements in the Netherlands and the United States is warranted in the light of the economic crisis triggered by unchecked capitalist practices in 2008. In Terug naar Walden Ruler Marsh, the richest man in the world, unleashes a global financial crisis as a form of retaliation against the capitalist system that ruined his parents. Marsh returns to the Kempen in Flanders where his family originated. In a Heideggerean affirmation of the local as exemplified by the country road, Van den Broeck articulates his vision of the common, that theorists Michael Hardt and Antonio Negri in their Empire trilogy have attempted to salvage from communist thinking, with a utopian notion that a stronger connection with the land and the people within one’s immediate environment may provide a useful premise for the development of viable alternatives to capitalism.

  6. Critica e derive del mito nell’opera di Walter Benjamin

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    Matteo Meloni

    2015-03-01

    Full Text Available La ri essione critica sul mito e sulle sue derive nel mondo moderno sono pre- senti in buona parte del pensiero benjaminiano. A cominciare dagli scritti di filosofia del linguaggio nei quali il mito biblico istituisce il fondamento ontologico della parola originaria, tra rifiuto della storia e messianismo, fino alle considerazioni sul diritto e sul concetto di destino nella società borghese. Ma è soprattutto nella critica letteraria che Benjamin espone le sue più brillanti intuizioni: dallo sprigionarsi delle forze primordiali della natura che, nelle Affinità elettive di Goethe, tra violenza del diritto e libertà etica, si impossessano dei personaggi, alla dialettica del “risveglio” con Proust e i surrealisti, e all’esperienza profonda della vie antérieur di Baudelaire. Così, senza mai distanziarsi dal radicamento della condizione storica del suo tempo e senza mai cadere in facile misticismo, Walter Benjamin ha acutamente ispezionato le tracce del mito nella modernità, auspicando con intelligenza la liberazione umana dalla schiavitù della barbarie contingenti.

  7. Alfred Walter Campbell and the visual functions of the occipital cortex.

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    Macmillan, Malcolm

    2014-07-01

    In his pioneering cytoarchitectonic studies of the human brain, Alfred Walter Campbell identified two structurally different areas in the occipital lobes and assigned two different kinds of visual functions to them. The first area, the visuosensory, was essentially on the mesial surface of the calcarine fissure. It was the terminus of nervous impulses generated in the retina and was where simple visual sensations arose. The second area, the visuopsychic, which surrounded or invested the first, was where sensations were interpreted and elaborated into visual perceptions. I argue that Campbell's distinction between the two areas was the starting point for the eventual differentiation of areas V1-V5. After a brief outline of Campbell's early life and education in Australia and of his Scottish medical education and early work as a pathologist at the Lancashire County Lunatic Asylum at Rainhill near Liverpool, I summarise his work on the human brain. In describing the structures he identified in the occipital lobes, I analyse the similarities and differences between them and the related structures identified by Joseph Shaw Bolton. I conclude by proposing some reasons for how that work came to be overshadowed by the later studies of Brodmann and for the more general lack of recognition given Campbell and his work. Those reasons include the effect of the controversies precipitated by Campbell's alliance with Charles Sherrington over the functions of the sensory and motor cortices. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Eurydice at Euston?: Walter Benjamin and Marc Augé Go Underground

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    Graeme Gilloch

    2014-01-01

    Full Text Available Taking as its point of departure Walter Benjamin’s repeatedly unsuccessful attempt to give spatial form to his past, this paper suggests that it is perhaps the contemporary French anthropologist, Marc Augé, who provides the most appropriate envisioning of a ‘map of memories’ in his brief writings on the Parisian métro system. For Augé, the labyrinthine subway network constitutes nothing less than a ‘memory machine’ in which lines and station names serve as mnemonics, recalling long-forgotten childhood encounters and experiences. Mirroring the cityscape above, places themselves unexplored, unknown, the serried toponyms of the métro become an incantation summoning forth the shades of the past. As Augé points out, those stations that provide opportunities to change lines are felicitously termed ‘correspondences’, a Baudelairean term that fascinated Benjamin and informed his key historiographical notion of the ‘dialectical image,’ the intersection and mutual illumination of past and present moments. For me, Augé’s highly suggestive reflections bring to mind my own memories of a London childhood around 1970. Looking at the London underground map today, I cannot but see the sites of many past meetings and partings, dots connected by lines forming complex figures, constellations of memory.

  9. Walter Benjamin em Gotham City: sobre a violência pura

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    Andityas Soares de Moura Costa Matos

    2016-12-01

    Full Text Available http://dx.doi.org/10.5007/2177-7055.2016v37n74p137 O presente trabalho reflete brevemente sobre as ideias de violência pura e de estado de exceção efetivo no pensamento de Walter Benjamin (1892-1940, lançando na seção 2 a hipótese de que são resultados de uma longa meditação que começa com o texto Sobre a crítica da violência (1921, passa pelo denso fragmento O caráter destrutivo (1931 e chega à obra intitulada Teses sobre o conceito de história (1940, quando Benjamin percebe com clareza à impossibilidade de se negociar com as instituições democrático-liberais, as quais funcionam como estruturas desaceleradoras (katéchonta do tempo da revolução, leitura apresentada na seção 1 mediante a profanação do conceito original schmittiano. O artigo passa então na seção 3 a interpretar as ideias de Benjamin em um cenário de ficção – a trilogia Batman de Christopher Nolan – que a cada dia parece mais terrivelmente real, concluindo com um parágrafo de sabor agambeniano sobre o direito-que-vem (seção 4.

  10. Genetic Drift. The ancient Egyptian dwarfs of the Walters Art Museum.

    Science.gov (United States)

    Kozma, Chahira

    2010-10-01

    The ancient Egyptians left an impressive artistic legacy documenting many aspects of their society including the existence of dwarfs as highly valued members. In previous publications in the Journal, I discussed dwarfs and skeletal dysplasia in ancient Egypt. In this study, I examined the ancient Egyptian representations of dwarfs of the Walters Art Museum in Baltimore, Maryland. One of the highlights of the collection is a group of five ivory figurines from Predynastic Times (pre 3500-3100 BCE) depicting a couple, a man with a child, and two females. Representations from other periods include ordinary as well as dwarf deities. The dwarf gods, Bes and Ptah, are frequently depicted holding or biting snakes or standing on crocodiles symbolizing their ability to ward off dangers. A couple of statuettes from the Greco-Roman Period that, in contrast to earlier Egyptian Periods, depict harsh physical anomalies, twisted bodies, and facial pain. The artistic impression can be interpreted as either tragic or humorous. The grotesque depiction of dwarfs during the Greco-Roman Period in ancient Egypt is believed to be due to a greater infusion of Hellenistic influence. This study provides a microcosm of the legacy of dwarfs in ancient Egypt and supports the premise that dwarfs were accepted and integrated in the ancient Egyptian society, and with a few exceptions, their disorder was not depicted as a physical handicap. Copyright © 2010 Wiley-Liss, Inc.

  11. Youth and pedagogy (On the genesis of the thought of Walter Benjamin

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    Lluís BALLESTER BRAGE

    2012-02-01

    Full Text Available The authors analyze the 16 early writings that W. Benjamin wrote between the ages of 19 and 23, all of which relate to educative matters, and where the decisive influence of G. Wyneken is shown. The issues that the young Walter Benjamin addresses are also studied, such as idealism and youth culture, the necessity of reform in schools and universities and also in moral, aesthetic and religious education as well as in juvenile sexuality. However, the most important thing is that in these works one can find the constants that characterize the rest of his production, such as his individualism, his obsession with his own childhood experiences, his contradictions and thematic transitions, his interest in aesthetics and art, the complexity of his work, his agnosticism and his consideration of Judaism as a cultural element, and above all his critical sense and his vocation for criticism which starts to become evident. Somehow in these articles of educative content one can discover many of the constants of what will be the subsequent work of this author.

  12. DESPERTAR DEL SUEÑO: WALTER BENJAMIN Y EL PROBLEMA DEL SHOCK

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    Guido Vespucci

    2010-01-01

    Full Text Available El presente artículo pretende analizar la noción de shock como una puerta de acceso a la obra de Walter Benjamin. A través de la exploración de algunos de sus escritos más originales (tales como «La obra de arte en la época de su reproductibilidad técnica», las «Tesis de filosofía de la historia», el Libro de los Pasajes, entre otros y sobre la base de una selección de ensayos acerca de su obra, intentaremos capturar la productividad analítica del concepto con el fin de poder iluminar su función operativa (filosófica y política, en el tratamiento que Benjamin realiza sobre una variedad de temas como el arte, la cultura, el capitalismo, la reproducción técnica y la experiencia del sujeto moderno.

  13. Hoarding symptoms among psychiatric outpatients: confirmatory factor analysis and psychometric properties of the Saving Inventory – Revised (SI-R

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    Siau Pheng Lee

    2016-10-01

    Full Text Available Abstract Background The growing interest in problematic hoarding as an independent clinical condition has led to the development of the Saving Inventory-Revised (SI-R to assess hoarding phenomenology. The SI-R is one of the most widely used instruments to measure hoarding symptoms; however, it lacks validation in non-Western samples. Methods The current study examined the construct, convergent, and discriminant validity of the SI-R among 500 outpatients at a psychiatric hospital in Singapore. The three-factor structure solution of the SI-R was fitted in a confirmatory factor analysis. Results The final model achieved mediocre fit (χ2 = 1026.02, df = 186; RMSEA = 0.095, SRMR = 0.06; CFI = 0.86; NNFI = 0.85. Two reverse-coded items (items 2 and 4 were removed due to insufficient factor loadings, resulting in the modified 21-item SI-R (SIR-21. Our findings indicate the need to further examine the construct validity of the SI-R, particularly in non-Western samples. Nonetheless, correlations with other hoarding-related constructs, such as anxiety (Beck Anxiety Inventory and depression (Beck Depression Inventory-II, supported the convergent and discriminant validity of the SIR-21 in our sample. Conclusions Findings in our current majority Chinese sample were consistent with previous observations from other Chinese samples. Implications were discussed from a cross-cultural perspective, such as cultural emphasis on saving for future use and overlap between the concepts of discarding and acquiring in Chinese samples. Future studies should also examine differences among other ethnic groups (e.g., Malay, Indian.

  14. Sir James Reid and the Death of Queen Victoria: An Early Model for End-of-Life Care.

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    Abrams, Robert C

    2015-12-01

    An appraisal of the last ten days of Queen Victoria's life, viewed primarily from the perspective of her personal physician, Sir James Reid, is presented. Sir James' clinical encounters with his patient and the Royal Family are examined to reveal his strategic and medical thinking and gauge his level of success in basic palliative aims. It was found that the lack of effective medical interventions, tensions within the Royal Family, the importance of his post to Sir James' professional career, and the political ramifications unavoidably connected with the illness of a head of state, all presented challenges to Reid's efforts to ease the physical and emotional pain of Queen Victoria's dying. Key features of Sir James' approach included reliance on physician-patient and physician-family relationships, emphasis on emotional support for the patient, and the careful selection of interventions for the family. In the first years of the 20th century, an era when the contemporary concepts of palliative care, hospice, and family dynamics did not exist, Sir James' management of the Queen's final illness suggested an early model for end-of-life care. By the end of Queen Victoria's life, Sir James was seen to have preserved his patient's comfort and dignity, at the same time advancing family and societal acceptance of the death of this matriarchal figure. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  15. Un taccuino a forma di strada. Su "Einbahnstrasse" di Walter Benjamin

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    Pier Giovanni Adamo

    2016-05-01

    Full Text Available La poetica di F. Schlegel ha realizzato una storicizzazione della teoria dei generi letterari sostituendo alla dicotomia del classicismo tra forma e contenuto una distinzione tra forma e spirito, secondo cui i materiali linguistico-tematici rappresentano i precipitati di quest’ultimo. Riprendendo questa intuizione di P. Szondi, potremmo affermare che, nella modernità letteraria, l’ibridazione è il processo di transizione dei materiali attraverso le forme. Un’opera tanto esemplare quanto strutturalmente rilevante, nell’orizzonte dell’ibridazione, è Einbahnstraße di Walter Benjamin, dove i materiali più disparati sono combinati a modellare una forma innovativa. Vi si mescolano stilemi della poesia in prosa, narrazione diaristica, (antimetodo surrealista, satira e intuizioni filosofiche. L’unicità, d’altra parte, risiede innanzitutto nell’essenza metacritica del procedimento organizzativo del libro: il frammentismo sistematico è un’applicazione pratica della teoria allegorica del montaggio, descritta nell’Ursprung des deutschen Trauerspiels. Il saggio si propone di leggere il testo come «un taccuino a forma di strada», anche per indagarne il valore di prologo al Passagenwerk, nato dall’avida lettura del Paysan de Paris di Aragon: istituisce un confronto per rilevare, nell’affinità di fondo, la  diversità di approccio tra il pensatore tedesco e il surrealismo, distinguendo tecniche di assemblaggio e ruolo dell’immaginario nell’uso di pubblicità e altri oggetti metropolitani. L’intenzione di una simile analisi di Einbahnstraße è dimostrare che Benjamin combina modelli letterari (Baudelaire, Proust, Kraus su tutti con i nuovi linguaggi artistici e le strategie discorsive della stampa per creare un’«immagine dialettica» dell’esistenza nel XX secolo.Friedrich Schlegel’s poetics realized a historicisation of literary genres theory by replacing classicist dichotomy between form and content with a

  16. Walter B. Cannon's World War I experience: treatment of traumatic shock then and now.

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    Ryan, Kathy L

    2018-06-01

    Walter B. Cannon (1871-1945), perhaps America's preeminent physiologist, volunteered for service with the Army Expeditionary Force (AEF) during World War I. He initially served with Base Hospital No. 5, a unit made up of Harvard clinicians, before moving forward to the front lines to serve at a casualty clearing station run by the British. During his time there, he performed research on wounded soldiers to understand the nature and causes of traumatic shock. Subsequently, Cannon performed animal experimentation on the causes of traumatic shock in the London laboratory of Dr. William Bayliss before being assigned to the AEF Central Medical Laboratory in Dijon, France, where he continued his experimental studies. During this time, he also developed and taught a curriculum on resuscitation of wounded soldiers to medical providers. Although primarily a researcher and teacher, Cannon also performed clinical duties throughout the war, serving with distinction under fire. After the war, Cannon wrote a monograph entitled Traumatic Shock (New York: Appleton, 1923), which encapsulated the knowledge that had been gained during the war, both from direct observation of wounded soldiers, as well as laboratory experimentation on the causes and treatment of traumatic shock. In his monograph, Cannon elucidates a number of principles concerning hemorrhagic shock that were later forgotten, only to be "rediscovered" during the current conflicts in Iraq and Afghanistan. This paper summarizes Cannon's wartime experiences and the knowledge gained concerning traumatic shock during World War I, with a comparison of current combat casualty care practices and knowledge to that which Cannon and his colleagues understood a century ago.

  17. Walter Baade: Father of the Two Stellar Populations and Pioneer Supernova Researcher

    Science.gov (United States)

    Osterbrock, D. E.

    2001-05-01

    Walter Baade was the great observational astronomer of the middle part of the past century. He lived and worked in Pasadena, where he ``discovered" the two stellar populations and did outstanding pioneer research on supernovae at Mount Wilson and Palomar Observatories from 1931 until 1959, when he returned to his native Germany, and died the following year. Baade was born in a little town in northwest Germany, and educated at Goettingen University, where he received his Ph.D. in 1919, just after the end of World War I. He got a research position at Hamburg Observatory, and quickly jumped into globular cluster and galactic structure work with its 40-in reflector, then the largest telescope in Europe. Baade recognized very early the great importance of the extremely rare ``highly luminous novae" which Heber D. Curtis and Knut Lundmark isolated in 1919-21. In 1929 Baade called these ``Hauptnovae" the key to measuring distances of faint galaxies. We call them supernovae today, a term he and Fritz Zwicky began using in 1932. Similarly Baade's first inkling that there was a spherically symmetric distribution of stars in our Galaxy, which he named Population II in his two great 1944 papers, came when he began picking up field RR Lyrae variables in 1926. Baade's research on the two stellar populations and supernovae was extremely important in opening up the whole fields of stellar and galactic evolution. His invited lectures at meetings and symposia, and his courses as a visiting professor inspired a whole generation of research astrophysicists. Baade's attractive personality made it possible for him to make his great discoveries in a land in which he was officially an enemy alien during World War II.

  18. Big Data and : Walter Lippmann and the fallacy of data privacy self-management

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    Jonathan A Obar

    2015-10-01

    Full Text Available In 1927, Walter Lippmann published The Phantom Public , denouncing the ‘mystical fallacy of democracy.’ Decrying romantic democratic models that privilege self-governance, he writes: “I have not happened to meet anybody, from a President of the United States to a professor of political science, who came anywhere near to embodying the accepted ideal of the sovereign and omnicompetent citizen.” Almost 90 years later, Lippmann’s pragmatism is as relevant as ever, and should be applied in new contexts where similar self-governance concerns persist. This paper does just that, repurposing Lippmann’s argument in the context of the ongoing debate over the role of the digital citizen in Big Data management. It is argued that proposals by the Federal Trade Commission, the White House and the US Congress, championing failed notice and choice privacy policy, perpetuate a self-governance fallacy comparable to Lippmann’s, referred to here as the fallacy of data privacy self-management . Even if the digital citizen had the faculties and the system for data privacy self-management, the digital citizen has little time for data governance. We desire the freedom to pursue the ends of digital production, without being inhibited by the means. We want privacy, and safety, but cannot complete all that is required for its protection. If it is true that the fallacy of democracy is similar to the fallacy of data privacy self-management, then perhaps the pragmatic solution is representative data management : a combination of non/for-profit digital dossier management via infomediaries that can ensure the protection of personal data, while freeing individuals from what Lippmann referred to as an ‘unattainable ideal.’

  19. De Walter Benjamin a Theodor Adorno: traços que permanecem na contemporaneidade

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    Carolina Diamantino Esser Santana

    2017-08-01

    Full Text Available O ensaio traz como base a crítica ao capitalismo, no que se refere aos efeitos negativos que ele impõe aos indivíduos, a partir dos estudos da primeira geração da Escola de Frankfurt. Analisar-se-á a história das ideias a partir de Walter Benjamin, Herbert Marcuse, Theodor Adorno e Max Horkheimer. Benjamin afirma que vive-se a perda da aura das obras de arte, já que a sua comercialização faz com que se perca a essência daquelas obras. Ademais, a imposição da novidade às obras e aos produtos consumidos representa uma ferramenta de manipulação do capitalismo, culminando na pobreza da experiência humana. Marcuse afirma que a sociedade vive o princípio do desempenho, que provoca modos de vida uniformizados, baseados numa concepção de trabalho e diversão homogêneos. Adorno propôs que o tempo livre provocava uma sensação de liberdade nos indivíduos, mas, na realidade, tratava-se do exercício de uma não liberdade, já que as formas de diversão seguiam à risca os padrões exigidos pelo capital. A partir do método adotado pela própria Teoria Crítica, afirma-se que a presente discussão teórica só se torna efetiva quando aplicada à prática, à sociedade atual.

  20. The influence of percutaneous nephrolithotomy on human systemic stress response, SIRS and renal function.

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    Shen, Pengfei; Wei, Wuran; Yang, Xiaochun; Zeng, Hao; Li, Xiong; Yang, Jie; Wang, Jia; Huang, Jiaoti

    2010-10-01

    The objective of this study is to investigate the influences of percutaneous nephrolithotomy (PNL) and open surgery nephrolithotomy on the systemic stress response, SIRS and renal function. Forty patients with kidney calculi were enrolled in the study. Twenty cases were randomized to the PNL group and the other twenty cases to the open surgery group. Levels of C-reactive protein (CRP), interleukin-6(IL-6), β(2)-microglobulin (β(2)-MG), respiration rate, heart rate, body temperature and white blood cell counts were examined. CRP and IL-6 were measured in all patients pre-operatively and on post-operative days 1, 3 and 6, respectively. There was significant difference in their pre- and post-operation levels (P PNL group and 12 cases in open surgery group; there was significant difference between the two groups (P 0.05). Urine β(2)-MG levels were also measured. There was significant difference between pre- and the first day post-PNL (P PNL (P > 0.05). There was significant difference between pre- and first and third day post-open surgery (P 0.05). There was significant difference between two groups at the first, third and sixth days (P PNL group and open surgery group to some extent. The degree of stress response of PNL is lower than that of open surgery, proving the advantages of PNL with reference to serum immunology. There were cases in both the groups with SIRS, but the degree of SIRS in PNL group was lesser than the other group. Both the groups have no obvious effect on glomerular filtration function after operation and have effect on renal tubular reabsorption in the early stage after operation; but the recovery of the PNL group is faster than the open surgery group. It is thus shown that PNL is much safer and more feasible and has lesser effect on renal function.

  1. A class of stochastic delayed SIR epidemic models with generalized nonlinear incidence rate and temporary immunity

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    Fan, Kuangang; Zhang, Yan; Gao, Shujing; Wei, Xiang

    2017-09-01

    A class of SIR epidemic model with generalized nonlinear incidence rate is presented in this paper. Temporary immunity and stochastic perturbation are also considered. The existence and uniqueness of the global positive solution is achieved. Sufficient conditions guaranteeing the extinction and persistence of the epidemic disease are established. Moreover, the threshold behavior is discussed, and the threshold value R0 is obtained. We show that if R0 extinct with probability one, whereas if R0 > 1, then the system remains permanent in the mean.

  2. The threshold of a stochastic delayed SIR epidemic model with vaccination

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    Liu, Qun; Jiang, Daqing

    2016-11-01

    In this paper, we study the threshold dynamics of a stochastic delayed SIR epidemic model with vaccination. We obtain sufficient conditions for extinction and persistence in the mean of the epidemic. The threshold between persistence in the mean and extinction of the stochastic system is also obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number Rbar0 of the deterministic system. Results show that time delay has important effects on the persistence and extinction of the epidemic.

  3. Global stability of an SIR model with differential infectivity on complex networks

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    Yuan, Xinpeng; Wang, Fang; Xue, Yakui; Liu, Maoxing

    2018-06-01

    In this paper, an SIR model with birth and death on complex networks is analyzed, where infected individuals are divided into m groups according to their infection and contact between human is treated as a scale-free social network. We obtain the basic reproduction number R0 as well as the effects of various immunization schemes. The results indicate that the disease-free equilibrium is locally and globally asymptotically stable in some conditions, otherwise disease-free equilibrium is unstable and exists an unique endemic equilibrium that is globally asymptotically stable. Our theoretical results are confirmed by numerical simulations and a promising way for infectious diseases control is suggested.

  4. Sir Charles Bell (1774-1842) and his contributions to early neurosurgery.

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    Tubbs, R Shane; Riech, Sheryl; Verma, Ketan; Mortazavi, Martin M; Loukas, Marios; Benninger, Brion; Cohen-Gadol, Aaron A

    2012-03-01

    The renowned surgeon, neuroanatomist, and artist Sir Charles Bell not only impacted the lives of his peers through his creative endeavors and passion for art, but also sparked noteworthy breakthroughs in the field of neuroscience. His empathetic nature and zest for life enabled him to develop an early proclivity for patient care. As a result of his innovative findings regarding sensory and motor nerves and the anatomical makeup of the brain, he accepted some of the most prestigious awards and received an honorable reputation in society. Bell is recognized for his diligence, perseverance, and his remarkable contributions to surgery. The present review will explore his contributions to the discipline now known as neurosurgery.

  5. Dynamics analysis of SIR epidemic model with correlation coefficients and clustering coefficient in networks.

    Science.gov (United States)

    Zhang, Juping; Yang, Chan; Jin, Zhen; Li, Jia

    2018-07-14

    In this paper, the correlation coefficients between nodes in states are used as dynamic variables, and we construct SIR epidemic dynamic models with correlation coefficients by using the pair approximation method in static networks and dynamic networks, respectively. Considering the clustering coefficient of the network, we analytically investigate the existence and the local asymptotic stability of each equilibrium of these models and derive threshold values for the prevalence of diseases. Additionally, we obtain two equivalent epidemic thresholds in dynamic networks, which are compared with the results of the mean field equations. Copyright © 2018 Elsevier Ltd. All rights reserved.

  6. Community of Faithful Dissidents. Representations of Anabaptism in Swiss Historical Fiction by Walter Laedrach and Katharina Zimmermann

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    Berit Jany

    2016-10-01

    Full Text Available The twentieth-century Swiss local authors Walter Laedrach and Katharina Zimmermann rediscovered the dark chapter of Swiss history documenting the torture and execution of non-resistant and non-conformist Christians in the Bernese Oberland. The following anal­ysis of the literary representation of these pacifist Anabaptists will identify historiographical sources that served as inspiration to the authors and the contributions their historical no­vels make in Switzerland’s process of coming to terms with its tragic past.

  7. Enhet og Dannelse : En idehistorisk analyse av enhets og dannelses idealet til Bauhaus direktøren Walter Gropius

    OpenAIRE

    Hansen, Britt Hogstad

    2003-01-01

    Sammendrag Denne avhandlingen presenterer et annet bild av den tyske arkitekten og pedagogen Walter Gropius (1883-1969) enn det som har vært vanlig til nå i Norge. Ofte blir han fremstilt som en av funksjonalismens fremste representanter og en som banet vei for den moderne arkitekturen. I denne sammenheng beskrives han ofte som en som brøt fullstendig med alle tidligere tradisjoner. Denne oppgaven vil derimot forsøke å vise at han ikke brøt med tidligere tradisjoner, men at han i høyeste ...

  8. RACISMO PRESENTE NA ANIMAÇÃO “SCRUB ME MAMA WITH A BOGGIE BEAT” DE WALTER LANTZ (1941)

    OpenAIRE

    Julio Geraldo Carvalho de Jesus; Davi Alexandre Pistila

    2017-01-01

    As Animações são fontes interessantes de serem exploradas pela perspectiva histórica, uma vez que trazem questões impostas pelo contexto da produção e podem ser utilizadas como meio de transmitir conhecimentos e ideologias. O presente artigo faz uma reflexão acerca do tema do racismo nas animações dirigidas e produzidas por Walter Lantz, no ano de 1941, tomando como base o cartoon “Scrube Me Mama with a Boogie Beat”, distribuído pela Universal Studios, e reexibido no ano de 1948. Apesar do ra...

  9. Faculty of health sciences, walter sisulu university: training doctors from and for rural South african communities.

    Science.gov (United States)

    Iputo, Jehu E

    2008-10-01

    Introduction The South African health system has disturbing inequalities, namely few black doctors, a wide divide between urban and rural sectors, and also between private and public services. Most medical training programs in the country consider only applicants with higher-grade preparation in mathematics and physical science, while most secondary schools in black communities have limited capacity to teach these subjects and offer them at standard grade level. The Faculty of Health Sciences at Walter Sisulu University (WSU) was established in 1985 to help address these inequities and to produce physicians capable of providing quality health care in rural South African communities. Intervention Access to the physician training program was broadened by admitting students who obtained at least Grade C (60%) in mathematics and physical science at standard grade, and who demonstrated appropriate personal attributes. An innovative curriculum, combining problem-based learning with community-based education (PBL/CBE) in small tutorial group settings, was also adopted. This approach was aimed at educating and graduating a broader cohort of students, while training future doctors to identify, analyze, and treat health problems in the rural South African context. Outcomes To date, 745 doctors (72% black Africans) have graduated from the program, and 511 students (83% black Africans) are currently enrolled. After the PBL/CBE curriculum was adopted, the attrition rate for black students dropped from 23% to 80%, and the proportion of students graduating within the minimum period rose from 55% to >70%. Many graduates are still completing internships or post-graduate training, but preliminary research shows that 36% percent of graduates practice in small towns and rural settings. Further research is underway to evaluate the impact of their training on health services in rural Eastern Cape Province and elsewhere in South Africa. Conclusions The WSU program increased access to

  10. [Sir Geoffrey Keynes 1887-1982. Surgical pioneer, medical historian, humanist].

    Science.gov (United States)

    Bergljung, Lars

    2005-01-01

    Sir Geoffrey Keynes (1887 - 1982), was a pioneer in the surgery of breast cancer and thymic deseases, n.b. in patients suffering from myastenia gravis. He strongly disapproved of the longstanding dogma of so called radical mastectomy in breast cancer, and advocated a more limited surgical approach, followed by radiation therapy. This was done more than fifty years before breastconserving surgery has become the therapy of choice and against considerable opposition from the surgical establishment of his days. He also became a pioneer in the surgical treatment of myastenia gravis by thymectomy, at a time when there was no real understanding of the pathophysiology of the disease and when considerable controversy existed as to the importance or non importance of concomitant tumour formation in the thymus. Besides being a busy surgeon Sir Geoffrey was a medical historian, writing the biography of among others William Harvey, a bibliographer with a special interest in the poet and artist William Blake and a bibliophil with a large book collection of great value to medical history.

  11. Investigating Environmentally Sustainable Transport Based on DALY weights and SIR Method

    Directory of Open Access Journals (Sweden)

    Hossein Nezamianpour Jahromi

    2012-09-01

    Full Text Available Accessibility is one of the main causes of well-being and growth in contemporary societies. Transportation is the backbone of accessibility systems that lead to the growth of economic and social networks and spatial dispersion of activities. Unfortunately, the adverse effects of transportation have a great impact on the natural and human environment. Since transportation is associated with fossil fuel combustion, it results in emissions of pollutants that cause damage to human health. To save the global eco-system, sustainable development has become an international priority. To deal with the sustainability of transportation systems is an important issue as testified by a growing number of initiatives framed to define and measure sustainability in transportation planning and infrastructure planning as well. The capability of environmental assessment as a sustainability instrument is well known. This study proposes a new approach to rank countries based on environmental sustainability development applying disability adjusted life year (DALY weights for transportation sector emissions. DALY weights consider actual impacts of pollutants on human health. By employing SIR method, a superiority and inferiority ranking method is presented for multiple criteria decision making, the sustainability ranking of a number of European countries is presented. Three various ranking methods extracted from SIR ranking method are discussed and the results and the correlation among them are demonstrated.

  12. New approaches to improve a WCDMA SIR estimator by employing different post-processing stages

    Directory of Open Access Journals (Sweden)

    Amnart Chaichoet

    2008-09-01

    Full Text Available For effective control of transmission power in WCDMA mobile systems, a good estimate of signal-to-interference ratio (SIR is needed. Conventionally, an adaptive SIR estimator employs a moving average (MA filter (Yoon et al., 2002 to encounter fading channel distortion. However, the resulting estimate seems to have high estimation error due to fluctuation in the channel variation. In this paper, an additional post-processing stage is proposed to improve the estimation accuracy by reducing the variation of the estimate. Four variations of post-processing stages, namely 1 a moving average (MA postfilter,2 an exponential moving average (EMA post-filter, 3 an IIR post-filter and 4 least-mean-squared (LMS adaptive post-filter, are proposed and their optimal performance in terms of root-mean-square error (RMSE are then compared by simulation. The results show the best comparable performance when the MA and LMS post-filter are used. However, the MA post-filter requires a lookup table of filter order for optimal performance at different channel conditions, while the LMS post-filter can be used conveniently without a lookup table.

  13. Medicinal use of earths and minerals from Hippocrates to Sir Hans Sloane and beyond.

    Science.gov (United States)

    Retsas, Spyros

    2012-12-01

    In 1931 two pharmaceutical drawers containing mineral specimens, belonging to Sir Hans Sloane, the 18th century collector, Royal Physician, President of the Royal Society and of the Royal College of Physicians of London, were found in the Department of Botany of the Natural History Museum (NHM) of London. The drawers, each divided into 49 compartments, contained a total of 107 mineral pharmaceutical specimens, some labelled as mercury or white arsenic. Their registration, identification with the Sloane Manuscript Catalogues and subsequent transfer to the Mineralogy department of the NHM where one of these drawers is now on public display, had been documented by 1935. In antiquity therapeutic empiricism attributed medicinal properties to animal products, plants and minerals, including the soil of specific geographic locations. This communication traces the medicinal use of certain earths and minerals, listed in Sir Hans Sloane's manuscript catalogues, to classical antiquity with a reference to Arsenic compounds, which in our time are finding application in the treatment of acute promyelocytic leukaemia and to Terra Lemnia, a celebrated antidote of repute spanning twenty centuries, also included in the Sloane collections.

  14. Influence of heat conductivity on the performance of RTV SIR coatings with different fillers

    Energy Technology Data Exchange (ETDEWEB)

    Siderakis, K [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, GR-26110 Patras (Greece); Agoris, D [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, Greece, GR-26500, Rion, Greece (Greece); Gubanski, S [High Voltage Laboratory, Department of Electric Power Engineering, Chalmers University of Technology, S-41296, Gothenburg (Sweden)

    2005-10-07

    Room temperature vulcanized silicone rubber (RTV SIR) coatings are employed in order to improve the pollution performance of high voltage ceramic insulators by imparting surface hydrophobicity. In this paper, the performance of three RTV SIR coatings containing different fillers is investigated in a salt-fog test. Alumina trihydrate (ATH) and silica are the fillers included in the formulation, aiming to increase the material endurance to the energy supplied by the surface electrical activity during periods of hydrophobicity loss. The primary action of these fillers is to increase the material heat conductivity, i.e. the amount of energy conducted to the substrate. In addition, in the case of ATH relief is also achieved due to particle decomposition. The results indicate that for the compositions commercially available, where low amounts of fillers are used, and under the conditions of the test, ATH filled coatings performed better than the silica filled ones. This is attributed to ATH decomposition which further relieves the material structure and therefore decelerates material aging.

  15. Ut Pictura Poesis : dialéctica entre palabras e imagen en Sir William Sterling Maxwell

    Directory of Open Access Journals (Sweden)

    Hilary Macartney

    2002-01-01

    Full Text Available En el presente artículo se analiza la estrecha relación entre la historia del arte de Sir William Stirling Maxwell, su biblioteca y su colección artística. Este vínculo encierra la clave para la comprensión de su excepcional aportación a la historiografía del arte español. Sus diversas actividades, como historiador del arte, coleccionista de libros y cuadros, y director de ediciones privadas de libros raros, fueron todas manifestaciones de su gran fascinación por el paralelo entre la literatura y el arte, la palabra y la imagen. Tal relación se encuentra incluso en el esquema decorativo de su biblioteca.This article examines the remarkable unity between Sir William Stirling Maxwell's art history, his library and his art collection and argües that this relationship is the key to understanding his unique contribution to scholarship of Spanish art. In particular, it will be shown that his actlvities as an art historian, bibliophile, art collector and editor of prívate editions of rare books were all expressions of his fascination with the relationship between literature and art in general, and more specifically between word and image. Even the decorative scheme of his library emphasised this relationship.

  16. Filtering authentic sepsis arising in the ICU using administrative codes coupled to a SIRS screening protocol.

    Science.gov (United States)

    Sudduth, Christopher L; Overton, Elizabeth C; Lyu, Peter F; Rimawi, Ramzy H; Buchman, Timothy G

    2017-06-01

    Using administrative codes and minimal physiologic and laboratory data, we sought a high-specificity identification strategy for patients whose sepsis initially appeared during their ICU stay. We studied all patients discharged from an academic hospital between September 1, 2013 and October 31, 2014. Administrative codes and minimal physiologic and laboratory criteria were used to identify patients at high risk of developing the onset of sepsis in the ICU. Two clinicians then independently reviewed the patient record to verify that the screened-in patients appeared to become septic during their ICU admission. Clinical chart review verified sepsis in 437/466 ICU stays (93.8%). Of these 437 encounters, only 151 (34.6%) were admitted to the ICU with neither SIRS nor evidence of infection and therefore appeared to become septic during their ICU stay. Selected administrative codes coupled to SIRS criteria and applied to patients admitted to ICU can yield up to 94% authentic sepsis patients. However, only 1/3 of patients thus identified appeared to become septic during their ICU stay. Studies that depend on high-intensity monitoring for description of the time course of sepsis require clinician review and verification that sepsis initially appeared during the monitoring period. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. The optimal dynamic immunization under a controlled heterogeneous node-based SIRS model

    Science.gov (United States)

    Yang, Lu-Xing; Draief, Moez; Yang, Xiaofan

    2016-05-01

    Dynamic immunizations, under which the state of the propagation network of electronic viruses can be changed by adjusting the control measures, are regarded as an alternative to static immunizations. This paper addresses the optimal dynamical immunization under the widely accepted SIRS assumption. First, based on a controlled heterogeneous node-based SIRS model, an optimal control problem capturing the optimal dynamical immunization is formulated. Second, the existence of an optimal dynamical immunization scheme is shown, and the corresponding optimality system is derived. Next, some numerical examples are given to show that an optimal immunization strategy can be worked out by numerically solving the optimality system, from which it is found that the network topology has a complex impact on the optimal immunization strategy. Finally, the difference between a payoff and the minimum payoff is estimated in terms of the deviation of the corresponding immunization strategy from the optimal immunization strategy. The proposed optimal immunization scheme is justified, because it can achieve a low level of infections at a low cost.

  18. A mixed SIR-SIS model to contain a virus spreading through networks with two degrees

    Science.gov (United States)

    Essouifi, Mohamed; Achahbar, Abdelfattah

    Due to the fact that the “nodes” and “links” of real networks are heterogeneous, to model computer viruses prevalence throughout the Internet, we borrow the idea of the reduced scale free network which was introduced recently. The purpose of this paper is to extend the previous deterministic two subchains of Susceptible-Infected-Susceptible (SIS) model into a mixed Susceptible-Infected-Recovered and Susceptible-Infected-Susceptible (SIR-SIS) model to contain the computer virus spreading over networks with two degrees. Moreover, we develop its stochastic counterpart. Due to the high protection and security taken for hubs class, we suggest to treat it by using SIR epidemic model rather than the SIS one. The analytical study reveals that the proposed model admits a stable viral equilibrium. Thus, it is shown numerically that the mean dynamic behavior of the stochastic model is in agreement with the deterministic one. Unlike the infection densities i2 and i which both tend to a viral equilibrium for both approaches as in the previous study, i1 tends to the virus-free equilibrium. Furthermore, since a proportion of infectives are recovered, the global infection density i is minimized. Therefore, the permanent presence of viruses in the network due to the lower-degree nodes class. Many suggestions are put forward for containing viruses propagation and minimizing their damages.

  19. Quantitative measurement of Y90 brehmmstrahlung images after of Y90 Sir-Spheres implantation to assess lung shunting

    International Nuclear Information System (INIS)

    Forwood, Nicholas J.; Pocock, Nicholas; Shin, Jane; Young, Andy M; Szeto, Edwin R.

    2009-01-01

    Full text: Background: In clinical practice the dose of Y 9 0 Sir-Spheres is calculated using a pre injection of Tc 9 9 m MAA. There is however a potential difference due to the different properties of Tc 9 9 m MAA and Y 9 0 Sir-Spheres. We assessed the concordance of lung shunting of Y 9 0 Sir-Spheres estimated using Y 9 0 Bremsstrahlung imaging, compared to shunting assessed using Tc 9 9 m MAA. Methods: 15 Patients were evaluated using 150-200 MBq of Tc 9 9 m MAA injected into the hepatic artery under angiographic guidance. Whole body images were acquired using a LEAP collimator (window of 140 kEv+/-10%). The patients were subsequently treated with Y 9 0 Sir-Spheres. After microspheres injection, whole body brehmsstrahlung images were acquired using a medium energy collimator (window settings of 75 kEv +/- 20%). Tc 9 9 m MAA images were paired with their corresponding bremsstrahlung image and lung shunting in the stu ides calculated simultaneously. Each paired dataset was analyzed by 5 operators. Results: The mean lung shunting for Tc 9 9 m MAA acquisition was 3.32% (SD 2.03) which was significantly lower than the lung shunting using the Y 9 0 acquisitions: mean 16.19% (SD of 6.43). The Pearson coefficient was r = 0.62 (p 9 0 Sir-Spheres bremsstrahlung imaging is higher than that calculated by Tc 9 9 m MAA imaging. The relationship is not sufficiently strong to use bremsstahlung imaging to retrospectively quantify the lung-to-liver shunting as indicated using Tc 9 9 M AA. Further studies are underway to assess the reliability of Tc 9 9 m MAA lung uptake calculations in determining the dose of Y 9 0 Sir-Spheres.

  20. Impulsive vaccination and dispersal on dynamics of an SIR epidemic model with restricting infected individuals boarding transports

    Science.gov (United States)

    Jiao, Jianjun; Cai, Shaohong; Li, Limei

    2016-05-01

    To understand the effect of impulsive vaccination and restricting infected individuals boarding transports on disease spread, we establish an SIR model with impulsive vaccination, impulsive dispersal and restricting infected individuals boarding transports. This SIR epidemic model for two regions, which are connected by transportation of non-infected individuals, portrays the evolvement of diseases. We prove that all solutions of the investigated system are uniformly ultimately bounded. We also prove that there exists globally asymptotically stable infection-free boundary periodic solution. The condition for permanence is discussed. It is concluded that the approach of impulsive vaccination and restricting infected individuals boarding transports provides reliable tactic basis for preventing disease spread.

  1. L’économie politique du désir dans le rituel et le militantisme au SriLanka

    Directory of Open Access Journals (Sweden)

    Wim Van Daele

    2013-03-01

    Full Text Available Le désir est au cœur des interactions complexes entre le développement et la religion. Cet article examine ses différentes expressions, comme étant une des préoccupations fondamentales de nombreuses religions, qui motivent à la fois le développement et les alternatives au développement. Au SriLanka, face au changement social, la forme néolibérale et mondialisée du développement est comprise et réinterprétée à travers des idiomes et des formations locales du désir. L’économie néolibérale cultive le désir et mène à un accroissement présumé de la présence des preta (fantômes affamés et avides qui se manifestent parfois au moment de la mort d’une personne. Les fantômes affamés, en tant que formations fétichisées du désir, trouvent un écho chez les consommateurs et les entrepreneurs, qui montrent unappétit insatiable vis-à-vis d’une richesse matérielle en constante croissance. Ainsi, l’apaisement ritualisé des fantômes affamés et le militantisme social de groupes tels que le Movement for National Land and Agricultural Reform (MONLAR sont clairement liés par leur préoccupation mutuelle face à l’insécurité existentielle des êtres humains et non humains, causée par un désir excessif et déséquilibré. L’action rituelle et le militantisme social divergent toutefois dans la formulation explicite de leurs préoccupations spécifiques concernant le désir. Le rituel matérialise et condense l’angoisse liée au désir, alors que le militantisme social décrit la fétichisation du désir en termes économiques, politiques et scientifiques plus abstraits.

  2. Ricardo Piglia lector de Walter Benjamin: compromiso político y vanguardia artística en los 70 argentinos.

    Directory of Open Access Journals (Sweden)

    Luis Ignacio García García

    2014-03-01

    This paper analyzes the reception of Walter Benjamin by the young Ricardo Piglia. Walter Benjamin, together with Bertolt Brecht, was very important for Piglia’s self-comprehension in the context of the agitated aesthetical-political debates of the ’60s and ’70s. Piglia makes use of the Brechtian Benjamin to articulate aesthetics and politics in a way that singles out his critical work in those years. He builds, from the parameters of a production aesthetic, a position that goes beyond not only the idealistic aesthetics but also the principles of the socialist realism, putting aside the opposition between aesthetic experimentation and politicization of art.

  3. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression

    International Nuclear Information System (INIS)

    Chang, C.-J.; Hsu, C.-C.; Yung, M.-C.; Chen, K.-Y.; Tzao Ching; Wu, W.-F.; Chou, H.-Y.; Lee, Y.-Y.; Lu, K.-H.; Chiou, S.-H.; Ma, H.-I

    2009-01-01

    CD133-expressing glioma cells play a critical role in tumor recovery after treatment and are resistant to radiotherapy. Herein, we demonstrated that glioblastoma-derived CD133-positive cells (GBM-CD133 + ) are capable of self-renewal and express high levels of embryonic stem cell genes and SirT1 compared to GBM-CD133 - cells. To evaluate the role of SirT1 in GBM-CD133 + , we used a lentiviral vector expressing shRNA to knock-down SirT1 expression (sh-SirT1) in GBM-CD133 + . Silencing of SirT1 significantly enhanced the sensitivity of GBM-CD133 + to radiation and increased the level of radiation-mediated apoptosis. Importantly, knock-down of SirT1 increased the effectiveness of radiotherapy in the inhibition of tumor growth in nude mice transplanted with GBM-CD133 + . Kaplan-Meier survival analysis indicated that the mean survival rate of GBM-CD133 + mice treated with radiotherapy was significantly improved by Sh-SirT1 as well. In sum, these results suggest that SirT1 is a potential target for increasing the sensitivity of GBM and glioblastoma-associated cancer stem cells to radiotherapy.

  4. dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

    Directory of Open Access Journals (Sweden)

    Kushal Kr. Banerjee

    2012-12-01

    Full Text Available Sir2, an evolutionarily conserved NAD+-dependent deacetylase, has been implicated as a key factor in mediating organismal life span. However, recent contradictory findings have brought into question the role of Sir2 and its orthologs in regulating organismal longevity. In this study, we report that Drosophila Sir2 (dSir2 in the adult fat body regulates longevity in a diet-dependent manner. We used inducible Gal4 drivers to knock down and overexpress dSir2 in a tissue-specific manner. A diet-dependent life span phenotype of dSir2 perturbations (both knockdown and overexpression in the fat body, but not muscles, negates the effects of background genetic mutations. In addition to providing clarity to the field, our study contrasts the ability of dSir2 in two metabolic tissues to affect longevity. We also show that dSir2 knockdown abrogates fat-body dFOXO-dependent life span extension. This report highlights the importance of the interplay between genetic factors and dietary inputs in determining organismal life spans.

  5. Threshold Dynamics in Stochastic SIRS Epidemic Models with Nonlinear Incidence and Vaccination

    Directory of Open Access Journals (Sweden)

    Lei Wang

    2017-01-01

    Full Text Available In this paper, the dynamical behaviors for a stochastic SIRS epidemic model with nonlinear incidence and vaccination are investigated. In the models, the disease transmission coefficient and the removal rates are all affected by noise. Some new basic properties of the models are found. Applying these properties, we establish a series of new threshold conditions on the stochastically exponential extinction, stochastic persistence, and permanence in the mean of the disease with probability one for the models. Furthermore, we obtain a sufficient condition on the existence of unique stationary distribution for the model. Finally, a series of numerical examples are introduced to illustrate our main theoretical results and some conjectures are further proposed.

  6. On pulse vaccine strategy in a periodic stochastic SIR epidemic model

    International Nuclear Information System (INIS)

    Wang, Fengyan; Wang, Xiaoyi; Zhang, Shuwen; Ding, Changming

    2014-01-01

    A periodic stochastic SIR epidemic model with pulse vaccination is studied. The system has global positive solutions and under some conditions it admits a unique positive periodic disease-free solution, which is globally exponentially stable in mean square. The mathematical expectation and variance of the positive periodic solution are obtained. Two threshold parameters R 1 and R 2 (R 1 >R 2 ) are identified; if R 1 <1, the susceptible will be persistent in the mean and the disease will go to extinction; if R 2 >1, the susceptible and the disease will be weakly persistent in the mean. We show that by repeatedly vaccinating the susceptible population in series of pulses, it is possible to eradicate the infective from the entire model population in the random environment

  7. Sir William Burnett (1779-1861), professional head of the Royal Naval Medical Department and entrepreneur.

    Science.gov (United States)

    Penn, Christopher

    2004-08-01

    Sir William Burnett (1779-1861) had an active career as a Royal Navy surgeon in the French Revolutionary and Napoleonic Wars, including service at the battles of St Vincent, the Nile and Trafalgar. From 1822 to 1855 he was professional head of the Royal Naval Medical Department, when he provided effective leadership in a time of great change. Although his official work earned him the reputation of a "hard-working, unimaginative, somewhat harsh man", his correspondence shows a very humane centre under the official carapace. His official performance and reputation were both eroded towards the end of his career by his determined promotion of zinc chloride, for which he held lucrative patents.

  8. Oceanographic data collected from the Sir John Franklin in the Beaufort Sea, September 1989

    Energy Technology Data Exchange (ETDEWEB)

    Macdonald, R W; Carmack, E C; O' Brien, M C; McLaughlin, F A; Minkley, B G; Berger-North, K

    1989-09-01

    The data reported here were collected from the Canadian Coast Guard ship Sir John Franklin during a cruise to the Canadian Beaufort Sea from August 21 to Sept 5, 1989. The cruise had two broad objectives: to collect chemical and conductivity temperature depth (CTD) data at a deep station in the Canadian Basin, and to survey intensively the shelf break with the Mackenzie Canyon as a focus. Conductivity temperature depth was measured using a CTD guideline system. Water samples consisting of hydrocast for 6 shelf edge stations at 200 m depth and one deep station at 3200 m depth were tested for salinity, temperature, dissolved oxygen, nutrients, and chlorophyll a. In addition, samples were collected for analysis of tritium, C-14, and oxygen isotope composition and acoustic profiles were run. Isotope composition and acoustic profile data are not included in this report.

  9. Sir John Macpherson, the first but sometimes overlooked Professor of Psychiatry at the University of Sydney.

    Science.gov (United States)

    White, Richard T

    2014-08-01

    To chronicle the creation of the Chair of Psychiatry at the University of Sydney, and the career and legacy, in New South Wales, of the first incumbent, Professor Sir John Macpherson CB MD FRCPE. The creation of the Chair, Macpherson's appointment, and his contributions to psychiatry in Sydney during the 52 months of his tenure, are well documented in contemporaneous sources and demonstrate that he was a very worthy Foundation Professor of Psychiatry at the University of Sydney. There are several possible reasons why Macpherson has been overlooked, including an erroneous statement in The World History of Psychiatry (1975) that William Siegfried Dawson, his successor from 1927 to 1952, was the first Professor of Psychiatry. © The Royal Australian and New Zealand College of Psychiatrists 2014.

  10. Threshold dynamics and ergodicity of an SIRS epidemic model with Markovian switching

    Science.gov (United States)

    Li, Dan; Liu, Shengqiang; Cui, Jing'an

    2017-12-01

    This paper studies the spread dynamics of a stochastic SIRS epidemic model with nonlinear incidence and varying population size, which is formulated as a piecewise deterministic Markov process. A threshold dynamic determined by the basic reproduction number R0 is established: the disease can be eradicated almost surely if R0 disease persists almost surely if R0 > 1. The existing method for analyzing ergodic behavior of population systems has been generalized. The modified method weakens the required conditions and has no limitations for both the number of environmental regimes and the dimension of the considered system. When R0 > 1, the existence of a stationary probability measure is obtained. Furthermore, with the modified method, the global attractivity of the Ω-limit set of the system and the convergence in total variation to the stationary measure are both demonstrated under a mild extra condition.

  11. Newton's gift how Sir Isaac Newton unlocked the system of the world

    CERN Document Server

    Berlinski, David

    2000-01-01

    Sir Isaac Newton, creator of the first and perhaps most important scientific theory, is a giant of the scientific era. Despite this, he has remained inaccessible to most modern readers, indisputably great but undeniably remote. In this witty, engaging, and often moving examination of Newton's life, David Berlinski recovers the man behind the mathematical breakthroughs. The story carries the reader from Newton's unremarkable childhood to his awkward undergraduate days at Cambridge through the astonishing year in which, working alone, he laid the foundation for his system of the world, his Principia Mathematica, and to the subsequent monumental feuds that poisoned his soul and wearied his supporters. An edifying appreciation of Newton's greatest accomplishment, Newton's Gift is also a touching celebration of a transcendent man.

  12. Granular statistical mechanics - Building on the legacy of Sir Sam Edwards

    Science.gov (United States)

    Blumenfeld, Raphael

    When Sir Sam Edwards laid down the foundations for the statistical mechanics of jammed granular materials he opened a new field in soft condensed matter and many followed. In this presentation we review briefly the Edwards formalism and some of its less discussed consequences. We point out that the formalism is useful for other classes of systems - cellular and porous materials. A certain shortcoming of the original formalism is then discussed and a modification to overcome it is proposed. Finally, a derivation of an equation of state with the new formalism is presented; the equation of state is analogous to the PVT relation for thermal gases, relating the volume, the boundary stress and measures of the structural and stress fluctuations. NUDT, Changsha, China, Imperial College London, UK, Cambridge University, UK.

  13. Optimizing Real-Time Vaccine Allocation in a Stochastic SIR Model.

    Directory of Open Access Journals (Sweden)

    Chantal Nguyen

    Full Text Available Real-time vaccination following an outbreak can effectively mitigate the damage caused by an infectious disease. However, in many cases, available resources are insufficient to vaccinate the entire at-risk population, logistics result in delayed vaccine deployment, and the interaction between members of different cities facilitates a wide spatial spread of infection. Limited vaccine, time delays, and interaction (or coupling of cities lead to tradeoffs that impact the overall magnitude of the epidemic. These tradeoffs mandate investigation of optimal strategies that minimize the severity of the epidemic by prioritizing allocation of vaccine to specific subpopulations. We use an SIR model to describe the disease dynamics of an epidemic which breaks out in one city and spreads to another. We solve a master equation to determine the resulting probability distribution of the final epidemic size. We then identify tradeoffs between vaccine, time delay, and coupling, and we determine the optimal vaccination protocols resulting from these tradeoffs.

  14. A stochastic SIRS epidemic model with infectious force under intervention strategies

    Science.gov (United States)

    Cai, Yongli; Kang, Yun; Banerjee, Malay; Wang, Weiming

    2015-12-01

    In this paper, we extend a classical SIRS epidemic model with the infectious forces under intervention strategies from a deterministic framework to a stochastic differential equation (SDE) one through introducing random fluctuations. The value of our study lies in two aspects. Mathematically, by using the Markov semigroups theory, we prove that the reproduction number R0S can be used to govern the stochastic dynamics of SDE model. If R0S 1, under mild extra conditions, it has an endemic stationary distribution which leads to the stochastical persistence of the disease. Epidemiologically, we find that random fluctuations can suppress disease outbreak, which can provide us some useful control strategies to regulate disease dynamics.

  15. The SIR model of Zika virus disease outbreak in Brazil at year 2015

    Science.gov (United States)

    Aik, Lim Eng; Kiang, Lam Chee; Hong, Tan Wei; Abu, Mohd Syafarudy

    2017-05-01

    This research study demonstrates a numerical model intended for comprehension the spread of the year 2015 Zika virus disease utilizing the standard SIR framework. In modeling virulent disease dynamics, it is important to explore whether the illness spread could accomplish a pandemic level or it could be eradicated. Information from the year 2015 Zika virus disease event is utilized and Brazil where the event began is considered in this research study. A three dimensional nonlinear differential equation is formulated and solved numerically utilizing the Euler's method in MS excel. It is appeared from the research study that, with health intercessions of public, the viable regenerative number can be decreased making it feasible for the event to cease to exist. It is additionally indicated numerically that the pandemic can just cease to exist when there are no new infected people in the populace.

  16. Sir William Turner (1832-1916) - Lancastrian, anatomist and champion of the Victorian era.

    Science.gov (United States)

    Wessels, Quenton; Correia, Janine Carla; Taylor, Adam M

    2016-11-01

    Sir William Turner, a Lancastrian, was renowned as a scientist, anatomist and a great reformer of medical education. His students became anatomists at various international institutions, which consequently shaped the future of anatomy as a subject matter both in the United Kingdom and in South Africa. Although Turner's accomplishments have been documented, little is known about the details that determined his career path and the individuals that shaped his future. Here the authors aim to highlight some aspects of Turner's academic achievements and his personal life as well as how he crossed paths with other great minds of the Victorian era including Richard Owen, Charles Darwin, James Paget and Joseph Lister. © The Author(s) 2015.

  17. Sir John Adams: his legacy to the world of particle accelerators

    CERN Document Server

    Wilson, E J N

    2011-01-01

    John Adams acquired an unrivalled reputation for his leading part in designing and constructing the Proton Synchrotron (PS) in CERN’s early days. In 1968, and after several years heading a fusion laboratory in the UK, he came back to Geneva to pilot the Super Proton Synchrotron (SPS) project to approval and then to direct its construction. By the time of his early death in 1984 he had built the two flagship proton accelerators at CERN and, during the second of his terms as Director-General, he laid the groundwork for the proton–antiproton collider which led to the discovery of the intermediate vector boson. How did someone without any formal academic qualification achieve this? What was the magic behind his leadership? The speaker, who worked many years alongside him, will discuss these questions and speculate on how Sir John Adams might have viewed today’s CERN.

  18. Stability and bifurcation analysis of an SIR epidemic model with logistic growth and saturated treatment

    International Nuclear Information System (INIS)

    Li, Jinhui; Teng, Zhidong; Wang, Guangqing; Zhang, Long; Hu, Cheng

    2017-01-01

    In this paper, we introduce the saturated treatment and logistic growth rate into an SIR epidemic model with bilinear incidence. The treatment function is assumed to be a continuously differential function which describes the effect of delayed treatment when the medical condition is limited and the number of infected individuals is large enough. Sufficient conditions for the existence and local stability of the disease-free and positive equilibria are established. And the existence of the stable limit cycles also is obtained. Moreover, by using the theory of bifurcations, it is shown that the model exhibits backward bifurcation, Hopf bifurcation and Bogdanov–Takens bifurcations. Finally, the numerical examples are given to illustrate the theoretical results and obtain some additional interesting phenomena, involving double stable periodic solutions and stable limit cycles.

  19. Maurice Couturier. Nabokov ou la cruauté du désir.

    Directory of Open Access Journals (Sweden)

    René Alladaye

    2006-04-01

    Full Text Available La lecture peut avoir partie liée avec la transgression. Maurice Couturier en apporte la preuve dans son dernier ouvrage, Nabokov ou la cruauté du désir, en enfreignant l’un des plus célèbres interdits nabokoviens, celui de la lecture psychanalytique de son œuvre. On se souvient des préfaces des romans où l’auteur ne se fait jamais faute de décourager la moindre velléité freudienne et d’une réponse des plus tranchantes administrée dans le cadre d’un entretien : « Laissons les crédules et les ...

  20. Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination.

    Directory of Open Access Journals (Sweden)

    Alison E Ringel

    Full Text Available Sir2 is an NAD(+-dependent histone deacetylase required to mediate transcriptional silencing and suppress rDNA recombination in budding yeast. We previously identified Tdh3, a glyceraldehyde 3-phosphate dehydrogenase (GAPDH, as a high expression suppressor of the lethality caused by Sir2 overexpression in yeast cells. Here we show that Tdh3 interacts with Sir2, localizes to silent chromatin in a Sir2-dependent manner, and promotes normal silencing at the telomere and rDNA. Characterization of specific TDH3 alleles suggests that Tdh3's influence on silencing requires nuclear localization but does not correlate with its catalytic activity. Interestingly, a genetic assay suggests that Tdh3, an NAD(+-binding protein, influences nuclear NAD(+ levels; we speculate that Tdh3 links nuclear Sir2 with NAD(+ from the cytoplasm.

  1. An individual-based approach to SIR epidemics in contact networks.

    Science.gov (United States)

    Youssef, Mina; Scoglio, Caterina

    2011-08-21

    Many approaches have recently been proposed to model the spread of epidemics on networks. For instance, the Susceptible/Infected/Recovered (SIR) compartmental model has successfully been applied to different types of diseases that spread out among humans and animals. When this model is applied on a contact network, the centrality characteristics of the network plays an important role in the spreading process. However, current approaches only consider an aggregate representation of the network structure, which can result in inaccurate analysis. In this paper, we propose a new individual-based SIR approach, which considers the whole description of the network structure. The individual-based approach is built on a continuous time Markov chain, and it is capable of evaluating the state probability for every individual in the network. Through mathematical analysis, we rigorously confirm the existence of an epidemic threshold below which an epidemic does not propagate in the network. We also show that the epidemic threshold is inversely proportional to the maximum eigenvalue of the network. Additionally, we study the role of the whole spectrum of the network, and determine the relationship between the maximum number of infected individuals and the set of eigenvalues and eigenvectors. To validate our approach, we analytically study the deviation with respect to the continuous time Markov chain model, and we show that the new approach is accurate for a large range of infection strength. Furthermore, we compare the new approach with the well-known heterogeneous mean field approach in the literature. Ultimately, we support our theoretical results through extensive numerical evaluations and Monte Carlo simulations. Published by Elsevier Ltd.

  2. May thrombopoietin be a useful marker of sepsis severity assessment in patients with SIRS entering the emergency department?

    Science.gov (United States)

    Segre, Elisabetta; Pigozzi, Luca; Lison, Davide; Pivetta, Emanuele; Bosco, Ornella; Vizio, Barbara; Suppo, Umberto; Turvani, Fabrizio; Morello, Fulvio; Battista, Stefania; Moiraghi, Corrado; Montrucchio, Giuseppe; Lupia, Enrico

    2014-10-01

    Thrombopoietin (TPO), a growth factor primarily involved in regulating thrombopoiesis, has been recently implicated in the pathogenesis of sepsis. TPO levels are, indeed, greatly increased in patients with sepsis compared to control subjects, and correlate with sepsis severity. The aim of this study was to evaluate TPO as predictive biomarker of sepsis and of sepsis severity in patients entering the emergency department (ED) with systemic inflammatory response syndrome (SIRS). This was a prospective observational study. Ours is a sub-study of the 'Need-speed trial', a multi-center observational study involving six Italian centers affiliated to the GREAT Italian Network. TPO was measured by ELISA. We enrolled 13 patients with SIRS (6 with acute pancreatitis, 3 with acute heart failure, 1 with pulmonary embolism, and 3 with allergic reactions), and 40 patients with sepsis, eight of whom had severe sepsis and three septic shock. TPO was significantly higher in patients with sepsis than with SIRS. In addition, TPO was higher in patients with severe sepsis than with sepsis, and in patients with septic shock than with severe sepsis, although these differences did not reach the statistical significance. Our preliminary results suggest that TPO may have the potential to be considered a promising early biomarker for both the diagnosis of sepsis and the assessment of sepsis severity in patients with SIRS entering the ED.

  3. Does SOFA predict outcomes better than SIRS in Brazilian ICU patients with suspected infection? A retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Regis Goulart Rosa

    2017-11-01

    Full Text Available We compared the discriminatory capacity of the sequential organ failure assessment (SOFA versus the systemic inflammatory response syndrome (SIRS score for predicting ICU mortality, need for and length of mechanical ventilation, ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition and SIRS (SIRS score ≥2 points. From January 2008 to December 2014, 1487 patients were admitted to the ICU due to suspected infection. SOFA ≥2 identified more septic patients than SIRS ≥2 (79.0% [n = 1175] vs. 68.5% [n = 1020], p  7 days (AUROC = 0.65 vs. 0.63, p = 0.004, and length of hospitalization >10 days (AUROC = 0.61 vs. 0.59, p 7 days.

  4. Spontaneous Transient Lateral Thoracic Lung Herniation Resulting in Systemic Inflammatory Response Syndrome (SIRS and Subsequent Contralateral Lung Injury

    Directory of Open Access Journals (Sweden)

    Antony Kaliyadan

    2011-01-01

    Full Text Available Lung herniation is a relatively rare clinical entity that is most commonly either congenital or acquired traumatically. We describe a case of spontaneous lung herniation secondary to acute cough in an obese male smoker complicated by contralateral acute lung injury and systemic inflammatory response syndrome (SIRS. Mechanisms of lung herniation, classification, diagnosis, and management will be discussed.

  5. Sir Charles Alfred Ballance (1856-1936) and the introduction of facial nerve crossover anastomosis in 1895

    NARCIS (Netherlands)

    Van de Graaf, Robert C.; Ijpma, Frank F. A.; Nicolai, Jean-Philippe A.

    Sir Charles Ballance (1856-1936) was the first surgeon in history to perform a facial nerve crossover anastomosis in 1895. Although, recently, several papers on the history of facial nerve surgery have been published, little is known about this historically important operation, the theoretical

  6. The use of multifrequency and polarimetric SIR-C/X-SAR data in geologic studies of Bir Safsaf, Egypt

    Science.gov (United States)

    Schaber, G.G.; McCauley, J.F.; Breed, C.S.

    1997-01-01

    Bir Safsaf, within the hyperarid 'core' of the Sahara in the Western Desert of Egypt, was recognized following the SIR-A and SIR-B missions in the 1980s as one of the key localities in northeast Africa, where penetration of dry sand by radar signals delineates previously unknown, sand-buried paleodrainage valleys ('radar-rivers') of middle Tertiary to Quaternary age. The Bir Safsaf area was targeted as a focal point for further research in sand penetration and geologic mapping using the multifrequency and polarimetric SIR-C/X-SAR sensors. Analysis of the SIR-C/X-SAR data from Bir Safsaf provides important new information on the roles of multiple SAR frequency and polarimetry in portraying specific types of geologic units, materials, and structures mostly hidden from view on the ground and on Landsat TM images by a relatively thin, but extensive blanket of blow sand. Basement rock units (granitoids and gneisses) and the fractures associated with them at Bir Safsaf are shown here for the first time to be clearly delineated using C- and L-band SAR images. The detectability of most geologic features is dependent primarily on radar frequency, as shown for wind erosion patterns in bedrock at X-band (3 cm wavelength), and for geologic units and sand and clay-filled fractures in weathered crystal-line basement rocks at C-band (6 cm) and L-band (24 cm). By contrast, Quaternary paleodrainage channels are detectable at all three radar frequencies owing, among other things, to an usually thin cover of blow sand. The SIR-C/X-SAR data investigated to date enable us to make specific recommendations about the utility of certain radar sensor configurations for geologic and paleoenvironmental reconnaissance in desert regions.Analysis of the shuttle imaging radar-C/X-synthetic aperture radar (SIR-C/X-SAR) data from Bir Safsaf provides important new information on the roles of multiple SAR frequency and polarimetry in portraying specific types of geologic units, materials, and

  7. Walter bustamante tejada, los invisibles en antioquia, 1886-1936: una arqueología de los discursos sobre la homosexualidad.

    OpenAIRE

    Bedoya Molina, Juan Pablo

    2011-01-01

    Los invisibles en Antioquia, 1886-1936: Una arqueología de los discursos sobre la homosexualidad del historiador Walter Alonso Bustamante Tejada, se presenta como un texto pionero para el estudio de la historia de la homosexualidad en Antioquia.

  8. Massenmedien und Bildung: Eine padagogische Interpretation der Adorno-Benjamin-Kontroverse (Mass Media and Education: A Pedagogical Interpretation of the Controversy between Theodore Adorno and Walter Benjamin).

    Science.gov (United States)

    Imai, Yasuo

    1997-01-01

    Gives a pedagogical interpretation of the controversy between Adorno (Theodore) and Benjamin (Walter). Sketches their different conceptions of what constitutes a pedagogical problem and discusses differences between their positions against the background of their shared concern, best described as "experiential poverty." (DSK)

  9. Peer-Assisted Learning Programme: Supporting Students in High-Risk Subjects at the Mechanical Engineering Department at Walter Sisulu University

    Science.gov (United States)

    Makola, Qonda

    2017-01-01

    The majority of the students who enroll at the Walter Sisulu University (WSU) in South Africa are not equipped with the necessary academic/learning skills to cope with the university environment, especially in Mechanical Engineering. The Department of Higher Education and Training (2013, p. 17), further states that "students' support is…

  10. Walter Gieseler, Komposition im 20. Jahrhundert. Details – Zusammenhänge, Celle, Moeck, 1975, pp. 228

    Directory of Open Access Journals (Sweden)

    Wilma D'Ambrosio

    2014-10-01

    Full Text Available Stupisce molto che un libro come Komposition im 20. Jahrhundert. Details - Zusammenhänge [Composizione nel 20° secolo. Particolari – Connessioni] di Walter Gieseler, pubblicato in Germania quasi venticinque anni fa, non abbia mai ricevuto un'attenzione maggiore. Strano destino, per un libro così ricco e innovativo, scritto da un autore cui andrebbe per lo meno tributato il merito di essere stato uno dei primi a realizzare una descrizione sistematica delle tecniche compositive novecentesche. Le ragioni vanno forse cercate nel fatto di non avere mai beneficiato di traduzioni in una lingua più ‘internazionale’ e di non appartenere, in senso convenzionale, né al settore propriamente analitico, né teorico-compositivo, né storico-musicale. Di fatto, il libro riassume tutti questi aspetti, nonché argomenti di materia estetica, esecutiva, psicologico-percettiva, notazionale, ecc.

  11. Fundamental Astronomy and Solar System Dynamics : Invited Papers Honoring Prof. Walter Fricke on the occasion of his 70th birthday

    CERN Document Server

    Lieske, J; Seidelmann, P

    1986-01-01

    "Fundamental Astronomy and Solar System Dynamics", a program of invited papers honoring Professor Walter Fricke, who for thirty years has been Director of the Astronomisches Rechen lnstitut in Heidelberg, was held at the Thompson Conference Center of the University of Texas at Austin on Wednesday 27 March 1985 on the occasion of his seventieth birthday and retirement as Director of ARl. Professor Fricke's contributions to astronomy encompass the areas of galactic dynamics, radial velocities, stellar statistics. the fundamental reference system and the constant of precession. Participants were welcomed to the Uni versi ty of Texas by Professor J. Parker Lamb, Chairman of the Department of Aerospace Engineering and Engineering Mechanics. The presentations ranged from discussions of astrometric problems concerned with the reference system, the constant of precession, major and minor planet observations, planetary ephemerides and lunar and satellite laser ranging, to a study of disc galaxies in massive halos. The...

  12. The two sides of the commodity. For an archeology of critical theory of consumption in the work of Walter Benjamin

    Directory of Open Access Journals (Sweden)

    Matías Romani

    2017-03-01

    Full Text Available The aim of this work is to trace a journey through the work of Walter Benjamin to give account of the existence of an incipient critical theory of consumption that appears, dispersed and fragmented among their major concerns as the status of the work of art, industrial technology or modern city. The idea that we intend to show is that the originality of Benjamin's proposal lies in the indirect nature by which access to the cultural question. Not so much as an instance derived from the production process determinations but from the transformations in the sphere of consumption. So the Arcades-Project can be read as a historic attempt to develop the contradiction of the commodity form that the consumer experience is presented as the cynical and utopian moment.

  13. Genomic Targets and Features of BarA-UvrY (-SirA Signal Transduction Systems.

    Directory of Open Access Journals (Sweden)

    Tesfalem R Zere

    Full Text Available The two-component signal transduction system BarA-UvrY of Escherichia coli and its orthologs globally regulate metabolism, motility, biofilm formation, stress resistance, virulence of pathogens and quorum sensing by activating the transcription of genes for regulatory sRNAs, e.g. CsrB and CsrC in E. coli. These sRNAs act by sequestering the RNA binding protein CsrA (RsmA away from lower affinity mRNA targets. In this study, we used ChIP-exo to identify, at single nucleotide resolution, genomic sites for UvrY (SirA binding in E. coli and Salmonella enterica. The csrB and csrC genes were the strongest targets of crosslinking, which required UvrY phosphorylation by the BarA sensor kinase. Crosslinking occurred at two sites, an inverted repeat sequence far upstream of the promoter and a site near the -35 sequence. DNAse I footprinting revealed specific binding of UvrY in vitro only to the upstream site, indicative of additional binding requirements and/or indirect binding to the downstream site. Additional genes, including cspA, encoding the cold-shock RNA-binding protein CspA, showed weaker crosslinking and modest or negligible regulation by UvrY. We conclude that the global effects of UvrY/SirA on gene expression are primarily mediated by activating csrB and csrC transcription. We also used in vivo crosslinking and other experimental approaches to reveal new features of csrB/csrC regulation by the DeaD and SrmB RNA helicases, IHF, ppGpp and DksA. Finally, the phylogenetic distribution of BarA-UvrY was analyzed and found to be uniquely characteristic of γ-Proteobacteria and strongly anti-correlated with fliW, which encodes a protein that binds to CsrA and antagonizes its activity in Bacillus subtilis. We propose that BarA-UvrY and orthologous TCS transcribe sRNA antagonists of CsrA throughout the γ-Proteobacteria, but rarely or never perform this function in other species.

  14. The Secret Life of Archives: Sally Siddons, Sir Thomas Lawrence, and The Material of Memory

    Directory of Open Access Journals (Sweden)

    Laura Engel

    2014-03-01

    Full Text Available This essay is in two parts, in the first I attempt to map out strategies for considering archival materials through the lens of performance, and in the second I enact or perform some of those strategies through a close reading of a letter from Sally Siddons, daughter of the famous actress Sarah Siddons, to the renown portrait painter and rakish bad boy, Sir Thomas Lawrence. I present a methodology that considers archival researchers as tourists who approach archival objects and images as material for curating a virtual exhibition. I argue that this strategy allows us to recognize and attempt to envision the interdisciplinary relationship amongst archival materials in order to imagine them in spatial, theatrical, and visual proximity to one another. In this way as researchers we are performing a kind of re-enactment, an animation, of the secret life of archives, which attempts to account the embodied traces of the past by providing an accessible thought provoking map for audiences.

  15. Vital endowments: Sir Charles Bell and the history of some congenital abnormalities of the upper limb.

    Science.gov (United States)

    Thurston, Alan

    2011-12-01

    Born in Edinburgh in 1774 Sir Charles Bell, as a young man, studied anatomy and surgery in his hometown. There followed a distinguished career that culminated in his becoming the first professor of Anatomy and Surgery at the College of Surgeons in London. Renowned as a brilliant neuroanatomist he was invited, on the advice of His Grace the Archbishop of Canterbury and the Bishop of London, to contribute one of eight volumes of a work on the Power Wisdom and Goodness of God as manifested in the Creation - known as the Bridgewater Treatises. 'The Hand its Mechanism and Vital Endowments as Evincing Design' was published in 1833 and it is an account of his considering the hand as a machine that has been engineered to exacting standards to interact with the environment in which we live. In it he expressed a deep understanding of the similarity of the structure of the upper limbs of the higher orders of animals. The similarity of the paddle of a turtle and a human hand with acrosymbrachydactyly is unmistakable. This congenital abnormality, given the eponymous title of Apert's syndrome, is one of a number of congenital abnormalities that have parallels in the animal kingdom. Others who have had similar syndromes named after them include Poland, Marfan, Streeter and a number of others. The life and times of these men and their contributions to medicine will be presented in this paper. © 2011 The Author. ANZ Journal of Surgery © 2011 Royal Australasian College of Surgeons.

  16. Sir Patrick Dun and the Complete School of Physic in eighteenth-century Dublin.

    Science.gov (United States)

    Mullaney, S

    2015-03-01

    2013 is the tercentenary of the death of Sir Patrick Dun. When Dun died in 1713, he left the proceeds of his estate to enhance medical education in Dublin by funding chairs in medicine. He showed remarkable innovation, but it took 95 years, five Acts of Parliament, two House of Commons enquiries and a House of Lords enquiry before Dun's wishes were brought to fruition and systematic clinical education was available for Dublin medical students. The passage of the final School of Physic Act in 1800 insured that a hospital would open in his name and regular clinical education was provided. The physician, Richard Steevens, who died 3 years earlier in 1710, left the proceeds of his estate to found a hospital, which opened, in his name, in 1733. The contemporary primary sources have been analysed and material from relevant secondary sources has been included where appropriate. Dublin was the beneficiary of these bequests and if circumstances had been more favourable, and the proceeds had been used more efficiently at the start of the eighteenth-century, Dublin could well have rivalled Edinburgh as the seat of medical education in the eighteenth century. In the early nineteenth century, it would fulfil that role and equal Edinburgh as one of the primary centres of medical education in Europe.

  17. Sir John Adams - His Legacy to the World of Particle Accelerators

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    John Adams acquired an unrivalled reputation for his leading part in designing and constructing the PS in CERN’s early days. In 1968, and after several years heading a fusion laboratory in the UK, he came back to Geneva to pilot the SPS project to approval and then to direct its construction. At the time of his untimely death in 1984 he had built Europe’s two largest proton accelerators at CERN. He went on, during the second of his terms as DG, to lay the groundwork for the proton-antiproton collider which led to the discovery of the intermediate vector boson. How did someone without any formal academic qualification achieve this? What was the magic behind his leadership? How did he achieve political success with the Member States of CERN in turning the almost hopeless quest for approval of the SPS to CERN’s advantage? How did he view his US counterpart, R. R. Wilson? The speaker, who worked many years alongside Adams, will discuss these questions and speculate on how Sir John Adams might have viewed t...

  18. A Historical Survey of Sir Karl Popper's Contribution to Quantum Mechanics

    Directory of Open Access Journals (Sweden)

    William M. Shields

    2012-11-01

    Full Text Available Sir Karl Popper (1902-1994, though not trained as a physicist and embarrassed early in his career by a physics error pointed out by Einstein and Bohr, ultimately made substantial contributions to the interpretation of quantum mechanics. As was often the case, Popper initially formulated his position by criticizing the views of others - in this case Niels Bohr and Werner Heisenberg. Underlying Popper's criticism was his belief that, first, the Copenhagen interpretation of quantum mechanics abandoned scientific realism and second, the assertion that quantum theory was complete (an assertion rejected by Einstein among others amounted to an unfalsifiable claim. Popper insisted that the most basic predictions of quantum mechanics should continue to be tested, with an eye towards falsification rather than mere adding of decimal places to confirmatory experiments. His persistent attacks on the Copenhagen interpretation were aimed not at the uncertainty principle itself and the formalism from which it was derived, but at the acceptance by physicists of an unclear epistemology and ontology that left critical questions unanswered. Quanta 2012; 1: 1–12.

  19. Sir William Osler's perceptions of urolithiasis and the case of the indigo calculus.

    Science.gov (United States)

    Moran, Michael E; Das, Sakti; Rosenberg, Stuart A

    2005-12-01

    Sir William Osler published his textbook, The Principles and Practice of Medicine, in 1892. It became the definitive treatise on a wide variety of diseases. The section on nephrolithiasis clearly presents the etiology, pathology, symptoms, diagnosis, and treatments. What remains a mystery is the mention, under rare forms of human stones, of a type called "indigo." A search of Index Medicus starting from 1909 backward to its inception in 1879 was performed for key words "indigo," "calculus," "renal" or "bladder stones" and "indicanuria." Twelve textbooks of urology published before 1940 were scrutinized for references to indigo calculi. Only two references to indigo were found, both related to its use for treating constipation (1887 and 1891). Of the 12 textbooks, only 4 make passing reference to "indigo stones." They all mention that such calculi are very rare, but direct references to cases are lacking. One textbook references a study of blue stones from Egyptian mummies. It is unlikely that Osler's reference to an indigo calculus was taken lightly during his writing of The Principles and Practice of Medicine. The case of the indigo calculus is fascinating and perhaps enlightening if only for the source of Osler's intrigue.

  20. Sir Karl Popper (1902-1994): in memoriam, 15 years later.

    Science.gov (United States)

    Notturno, Mark Amadeus

    2009-12-01

    September 17th, 2009 marks the 15th anniversary of Sir Karl Popper's death. Popper was an outspoken champion of critical rationalism, and a constant critic of authoritarian tendencies in science and society. He was also one of the spiritual founders of this journal and served on its first editorial advisory board. Popper was recognized around the world as one of the 20th century's greatest philosophers of science and one of its most articulate and influential critics of Marxism and closed society. When he died, the contemporary wisdom among professional philosophers was that his philosophy was generally right-but somehow obsolete. Some commentators said that it was now obvious that scientific theories cannot be shown to be true. Others said that we had witnessed the end of history and that his critique of closed societies, while no doubt important in its day, had been fully assimilated into Western thinking and still had meaning, if at all, only for the democracies in transition that were trying to emerge from the former Soviet Union. But 15 years after his death, a look at science and society around the world gives us good reason to remember his philosophy.

  1. Contribuciones de Sir Roland Fisher a la Estadística Genética

    Directory of Open Access Journals (Sweden)

    Jaime Cuadros

    2004-11-01

    Full Text Available Sir Ronald Fisher (18901962 fue profesor de genética y muchas de sus innovaciones estadísticas encontraron expresión en el desarrollo de metodología en estadística genética. Sin embargo, mientras sus contribuciones en estadística matemática son fácilmente identificadas, en genética de poblaciones compartió su supremacía con Sewall Wright (1889 1988 y J. S. S. Haldane (1892 1965. Este documento muestra algunas de las mejores contribuciones de Fisher a las bases de la estadística genética, y sus interacciones con Wright y Haldane, los cuales contribuyeron al desarrollo del tema. Con la tecnología moderna, tanto la metodología la estadística como la información genética están cambiando. No obstante, muchos de los trabajos de Fisher permanecen relevantes, y pueden aun servir como una base para investigaciones futuras en el análisis estadístico de datos de DNA. El trabajo de este autor refleja su visión del papel de Ia estadística en Ia inferencia científica expresada en 1949

  2. SIRS Model of Passengers’ Panic Propagation under Self-Organization Circumstance in the Subway Emergency

    Directory of Open Access Journals (Sweden)

    Haifeng Zhao

    2014-01-01

    Full Text Available Subway emergency may lead to passengers’ panic, especially under self-organizing circumstance, which will spread rapidly and have an adverse impact on the society. This paper builds an improved SIRS model of passengers’ panic spread in subway emergency with consideration of passengers’ density, the characteristic of subway car with the confined space, and passengers’ psychological factors. The spread of passengers’ panic is simulated by use of Matlab, which draws the rules of how group panic spreads dynamically. The trend of stable point of the infection ratio is analyzed by changing different parameters, which help to draw a conclusion that immunization rate, spontaneous immune loss rate, and passenger number have a great influence on the final infected ratio. Finally, we propose an integrated control strategy and find the peak of passengers’ panic and the final infected ratio is greatly improved through the numerical simulation. The research plays a vital role in helping the government and subway administration to master the panic spread mechanism and reduce the panic spread by improving measures and also provides certain reference significance for rail system construction, emergency contingency plans, and the construction and implementation of emergency response system.

  3. Classification of surface types using SIR-C/X-SAR, Mount Everest Area, Tibet

    Science.gov (United States)

    Albright, Thomas P.; Painter, Thomas H.; Roberts, Dar A.; Shi, Jiancheng; Dozier, Jeff; Fielding, Eric

    1998-01-01

    Imaging radar is a promising tool for mapping snow and ice cover in alpine regions. It combines a high-resolution, day or night, all-weather imaging capability with sensitivity to hydrologic and climatic snow and ice parameters. We use the spaceborne imaging radar-C/X-band synthetic aperture radar (SIR-C/X-SAR) to map snow and glacial ice on the rugged north slope of Mount Everest. From interferometrically derived digital elevation data, we compute the terrain calibration factor and cosine of the local illumination angle. We then process and terrain-correct radar data sets acquired on April 16, 1994. In addition to the spectral data, we include surface slope to improve discrimination among several surface types. These data sets are then used in a decision tree to generate an image classification. This method is successful in identifying and mapping scree/talus, dry snow, dry snow-covered glacier, wet snow-covered glacier, and rock-covered glacier, as corroborated by comparison with existing surface cover maps and other ancillary information. Application of the classification scheme to data acquired on October 7 of the same year yields accurate results for most surface types but underreports the extent of dry snow cover.

  4. Different strategies of osmoadaptation in the closely related marine myxobacteria Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1.

    Science.gov (United States)

    Amiri Moghaddam, Jamshid; Boehringer, Nils; Burdziak, Amal; Kunte, Hans-Jörg; Galinski, Erwin A; Schäberle, Till F

    2016-02-03

    Only a few myxobacteria are known to date which are classified as marine due to their salt-dependency. In this study, the salt tolerance mechanism of these bacteria was investigated. Therefore, a growth medium was designed, in which the mutated Escherichia coli strain BKA13 served as sole food source for the predatory, heterotrophic myxobacteria. This enabled measurement of the osmolytes without any background and revealed that the closely related strains Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1 developed different strategies to handle salt stress. P. pacifica SIR-1, which was grown between 1-4 % NaCl, relies solely on the accumulation of amino acids, while E. salina SWB007, which was grown between 0.5-3 % NaCl, employs, beside betaine, hydroxyectoine as the major compatible solute. In accordance with this analysis, only in the latter strain a gene locus was identified which codes for genes corresponding to the biosynthesis of betaine, ectoine, and hydroxyectoine.

  5. Positron-emitting resin microspheres as surrogates of 90Y SIR-Spheres: a radiolabeling and stability study

    International Nuclear Information System (INIS)

    Avila-Rodriguez, Miguel A.; Selwyn, Reed G.; Hampel, Joseph A.; Thomadsen, Bruce R.; DeJesus, Onofre T.; Converse, Alexander K.; Nickles, Robert J.

    2007-01-01

    Commercially available resin microspheres and SIR-Spheres were labeled with metallic positron emitters and evaluated as positron emission tomography (PET) imaging surrogates of 90 Y SIR-Spheres. Radiolabeling was performed using a batch method, and in vitro stability over 24 h was evaluated in saline at physiological pH at 37 o C. The activity per microsphere distribution, as evaluated by autoradiography, showed the activity per microsphere to be proportional to the square radius of the spheres, suggesting surface binding. The in vivo stability of radiolabeling was evaluated in rats by micro-PET imaging after the intravenous injection of labeled microspheres. The different resin microspheres and radionuclides evaluated in this study all showed good radiolabeling efficiency and in vitro stability. However, only resins labeled with 86 Y and 89 Zr proved to have the in vivo stability required for clinical applications

  6. Deforestation and Secondary Growth in Rondonia, Brazil from SIR-C SAR and Landsat.SPOT data

    Science.gov (United States)

    Rignot, Eric; Salas, William A.; Skole, David L.

    1996-01-01

    Covers problems with existing data collected with high-resolution optical sensors. They say active microwave sensors could complement other sensors in getting through things like cloud cover. They analyzed SIR-C data in combination with Landsat TM data, a 9-year time series of SPOT XS data, and a preliminary field survey. They report findings and draw conclusions, including that SARs operating at long radar wavelengths, with both like and cross-polarizations, are needed for tropical deforestation studies.

  7. The β-1,3-glucanosyltransferase Gas1 regulates Sir2-mediated rDNA stability in Saccharomyces cerevisiae.

    Science.gov (United States)

    Ha, Cheol Woong; Kim, Kwantae; Chang, Yeon Ji; Kim, Bongkeun; Huh, Won-Ki

    2014-07-01

    In Saccharomyces cerevisiae, the stability of highly repetitive rDNA array is maintained through transcriptional silencing. Recently, a β-1,3-glucanosyltransferase Gas1 has been shown to play a significant role in the regulation of transcriptional silencing in S. cerevisiae. Here, we show that the gas1Δ mutation increases rDNA silencing in a Sir2-dependent manner. Remarkably, the gas1Δ mutation induces nuclear localization of Msn2/4 and stimulates the expression of PNC1, a gene encoding a nicotinamidase that functions as a Sir2 activator. The lack of enzymatic activity of Gas1 or treatment with a cell wall-damaging agent, Congo red, exhibits effects similar to those of the gas1Δ mutation. Furthermore, the loss of Gas1 or Congo red treatment lowers the cAMP-dependent protein kinase (PKA) activity in a cell wall integrity MAP kinase Slt2-dependent manner. Collectively, our results suggest that the dysfunction of Gas1 plays a positive role in the maintenance of rDNA integrity by decreasing PKA activity and inducing the accumulation of Msn2/4 in the nucleus. It seems that nuclear-localized Msn2/4 stimulate the expression of Pnc1, thereby enhancing the association of Sir2 with rDNA and promoting rDNA stability. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  8. Patterns of Gram-stained fecal flora as a quick diagnostic marker in patients with severe SIRS.

    Science.gov (United States)

    Shimizu, Kentaro; Ogura, Hiroshi; Tomono, Kazunori; Tasaki, Osamu; Asahara, Takashi; Nomoto, Koji; Morotomi, Masami; Matsushima, Asako; Nakahori, Yasutaka; Yamano, Shuhei; Osuka, Akinori; Kuwagata, Yasuyuki; Sugimoto, Hisashi

    2011-06-01

    The gut is an important target organ of injury during critically ill conditions. Although Gram staining is a common and quick method for identifying bacteria, its clinical application has not been fully evaluated in critically ill conditions. This study's aims were to identify patterns of Gram-stained fecal flora and compare them to cultured bacterial counts and to investigate the association between the patterns and septic complications in patients with severe systemic inflammatory response syndrome (SIRS). Fifty-two patients with SIRS were included whose Gram-stained fecal flora was classified into three patterns. In a diverse pattern, large numbers of multiple kinds of bacteria completely covered the field. In a single pattern, one specific kind of bacteria or fungi predominantly covered the field. In a depleted pattern, most bacteria were diminished in the field. In the analysis of fecal flora, the numbers of total obligate anaerobes in the depleted pattern was significantly lower than those in the diverse pattern and single pattern (p Gram-stained fecal flora can be classified into three patterns and are associated with both cultured bacterial counts and clinical information. Gram-stained fecal bacteria can be used as a quick bedside diagnostic marker for severe SIRS patients.

  9. Agro-transformation and evaluation of resistance to Phytophthora infestansin Solanum tuberosumL. variety Désirée

    Directory of Open Access Journals (Sweden)

    Jeanette Orbegozo

    2014-03-01

    Full Text Available The Oomycete Phytophthora infestans (Mont. de Bary, the causal agent of the disease known as late blight, is primarily responsible for the decreased in production performance and potato crops worldwide. The integration of the complete Rgenes sequences in the potato genome using Agro-transformation appears an alternative to be considered in the fight against this pathogen. The Rpi-blb2 gene (Rgene from the wild species Solanum bulbocastanumDunal shows a broad resistance to isolates ofP. infestans,making it an important candidate for plant breeding studies. This paper reports the integration of the Rpi-blb2gene into potato var. Désirée genome by Agrobacterium tumefaciens- mediated transformation system, the molecular characterization of 29 events transformed and whole plant infection with isolate POX67 of P. infestansfrom Peru. Désirée events [Rpi-blb2] 4 and Désirée [Rpi-blb2] 30, showed a substantial resistance to P. infestansinfection confirming complete transfer of the Rpi-blb2gene from a wild species to a cultivated species by genetic transformation.

  10. Procalcitonin, C-reactive protein and serum lactate dehydrogenase in the diagnosis of bacterial sepsis, SIRS and systemic candidiasis.

    Science.gov (United States)

    Miglietta, Fabio; Faneschi, Maria Letizia; Lobreglio, Giambattista; Palumbo, Claudio; Rizzo, Adriana; Cucurachi, Marco; Portaccio, Gerolamo; Guerra, Francesco; Pizzolante, Maria

    2015-09-01

    The aim of this study was to evaluate procalcitonin (PCT), C-reactive protein (CRP), platelet count (PLT) and serum lactate dehydrogenase (LDH) as early markers for diagnosis of SIRS, bacterial sepsis and systemic candidiasis in intensive care unit (ICU) patients. Based on blood culture results, the patients were divided into a sepsis group (70 patients), a SIRS group (42 patients) and a systemic candidiasis group (33 patients). PCT, CRP, LDH and PLT levels were measured on day 0 and on day 2 from the sepsis symptom onset. PCT levels were higher in Gram negative sepsis than those in Gram positive sepsis, although the P value between the two subgroups is not significant (P=0.095). Bacterial sepsis group had higher PCT and CRP levels compared with the systemic candidiasis group, whereas PLT and LDH levels showed similar levels in these two subgroups. The AUC for PCT (AUC: 0.892, P candidiasis groups (P=0.093 N.S.). In conclusion, PCT can be used as a preliminary marker in the event of clinical suspicion of systemic candidiasis; however, low PCT levels (candidiasis and SIRS groups.

  11. Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2.

    Science.gov (United States)

    Bheda, Poonam; Swatkoski, Stephen; Fiedler, Katherine L; Boeke, Jef D; Cotter, Robert J; Wolberger, Cynthia

    2012-04-17

    Although the biological roles of many members of the sirtuin family of lysine deacetylases have been well characterized, a broader understanding of their role in biology is limited by the challenges in identifying new substrates. We present here an in vitro method that combines biotinylation and mass spectrometry (MS) to identify substrates deacetylated by sirtuins. The method permits labeling of deacetylated residues with amine-reactive biotin on the ε-nitrogen of lysine. The biotin can be utilized to purify the substrate and identify the deacetylated lysine by MS. The biotinyl-lysine method was used to compare deacetylation of chemically acetylated histones by the yeast sirtuins, Sir2 and Hst2. Intriguingly, Sir2 preferentially deacetylates histone H3 lysine 79 as compared to Hst2. Although acetylation of K79 was not previously reported in Saccharomyces cerevisiae, we demonstrate that a minor population of this residue is indeed acetylated in vivo and show that Sir2, and not Hst2, regulates the acetylation state of H3 lysine 79. The in vitro biotinyl-lysine method combined with chemical acetylation made it possible to identify this previously unknown, low-abundance histone acetyl modification in vivo. This method has further potential to identify novel sirtuin deacetylation substrates in whole cell extracts, enabling large-scale screens for new deacetylase substrates.

  12. PALEODRAINAGES OF THE EASTERN SAHARA - THE RADAR RIVERS REVISITED (SIR - A/B IMPLICATIONS FOR A MID - TERTIARY TRANS - AFRICAN DRAINAGE SYSTEM).

    Science.gov (United States)

    McCauley, John F.; Breed, Carlos S.; Schaber, Gerald G.; McHugh, William P.; Issawi, Bahay; Haynes, C. Vance; Grolier, Maurice J.; El Kilani, Ali

    1986-01-01

    A complex history of Cenozoic fluvial activity in the presently hyperarid eastern Sahara is inferred from Shuttle Imaging Radar (SIR) data and postflight field investigations in southwest Egypt and northwest Sudan. SIR images were coregistered with Landsat and existing maps as a guide to exploration of the buried paleodrainages (radar rivers) first discovered by SIR-A. Field observations explain the radar responses of three types of radar rivers: RR-1, RR-2, and RR-3. A generalized model of the radar rivers, based on field studies and regional geologic relations, shows apparent changes in river regimen since the large valleys were established during the late Paleogene-early Neogene eras. SIR-based mapping of these paleodrainages, although incomplete, reveals missing links in an area once thought to be devoid of master streams.

  13. Sir Francis Joseph Campbell and His Family: The First Family in Professional Services for People Who Are Blind or Visually Impaired

    Science.gov (United States)

    Welsh, Richard L.

    2008-01-01

    The author discusses the pivotal roles of Sir Francis Campbell (1832-1914) and members of his family, especially his son Charles Campbell, in the evolution of the blindness field to a professional and reason-based service.

  14. Antropologia e filosofia: estética e experiência em Clifford Geertz e Walter Benjamin

    Directory of Open Access Journals (Sweden)

    Relivaldo Pinho de Oliveira

    2012-06-01

    Full Text Available Este artigo estuda as concepções de estética e experiência de Clifford Geertz e Walter Benjamin como possibilidades argumentativas e metodológicas para pensar a realidade e suas formas estéticas. Utiliza-se para isso as discussões metodológicas de Geertz, especialmente a respeito do lugar da estética e de sua relação com os demais âmbitos do humano, que encetaram uma nova forma de concebê-los para a etnografia e antropologia de modo geral, e os estudos de Benjamin a respeito da estética como expressão fisionômica de uma época, de determinada realidade, especialmente os que se referem sobre a modernidade. Constata-se essa possibilidade a partir da observação de que a estética e a experiência, nos autores, são tomadas como dimensões da realidade que se relacionam, não de modo mecânico, e sim como âmbitos que atravessam a realidade, os artefatos estéticos, os discursos, e esses assim devem ser observados.This article study the conceptions of aesthetics and experience of Clifford Geertz and Walter Benjamin as argumentative and methodological possibilities for thinking reality and its aesthetic forms. Uses for this Geertz's methodological discussions, especially regarding the place of aesthetics and its relation to other spheres of the human, which has embarked on a new way of conceiving them to ethnography and anthropology in general, and studies Benjamin about the aesthetics and physiognomical expression of an era, a certain reality, especially those concerning about modernity. There is that possibility from the observation that the aesthetics and experience, in the authors, are taken as the dimensions of reality are related, not mechanically, but as areas that cross the reality, the aesthetic artifacts, the speeches, and so these must be observed.

  15. Walter Max Dale (formerly Deutsch) (1894-1969): pioneer and eminent radiobiochemist at the Christie Hospital and Holt Radium Institute, Manchester.

    Science.gov (United States)

    Shreeve, David R

    2010-05-01

    The political upheaval in Germany in 1933 and subsequent movement of medical scholars with the support of the Rockefeller Foundation allowed Manchester to benefit from the arrival of Dr Walter Deutsch, later known as Dr Walter Dale. His research background enabled him to develop a radiobiochemistry laboratory at the Christie Hospital and Holt Radium Institute where he became a world authority on the effects of X-rays on enzymes and also the protective effect of additional solutes. In 1959 he initiated and then edited the International Journal of Radiation Biology. By the time of his retirement in 1962 the strength of his research resulted in his laboratory being recognized by the Medical Research Council.

  16. Clima e vegetação natural do estado do Rio Grande do Sul segundo o diagrama climático de Walter e Lieth

    Directory of Open Access Journals (Sweden)

    Galileo Adeli Buriol

    2007-01-01

    Full Text Available The natural vegetation in the State of Rio Grande do Sul was related to climatic availability through the climatic diagram of Walter and Lieth (1967. Values of mean monthly air temperature and rainfall from 41 meteorological stations during the period 1931-1960 were taken into account. For each meteorological station, a graph was plotted with months in the x axis and monthly air temperature and rainfall in the two y axis considering the y axis with rainfall two fold the y axis with air temperature. Results showed that Rio Grande do Sul as a whole fits in the zonobioma of warm humid temperate climate and forest vegetation. These results indicate the phytoclimate model of Walter and Lieth (1967 is not appropriate to represent the geographic distribution of the natural vegetation of the State, because this type of vegetation is not only that which covers the State that because it also parents praises.

  17. SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation

    Energy Technology Data Exchange (ETDEWEB)

    Xie, Yuexia [Institute of Radiation Medicine, Fudan University, Shanghai (China); Central Laboratory, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai (China); Tu, Wenzhi; Zhang, Jianghong; He, Mingyuan; Ye, Shuang; Dong, Chen [Institute of Radiation Medicine, Fudan University, Shanghai (China); Shao, Chunlin, E-mail: clshao@shmu.edu.cn [Institute of Radiation Medicine, Fudan University, Shanghai (China)

    2015-02-15

    Highlights: • γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells. • SirT1 played a protective role in regulating this bystander effect. • SirT1 contributed to the protective effects via elimination the accumulation of ROS. • The activity of c-Myc is critical for maintaining the protective role of SirT1. - Abstract: Radiation-induced bystander effect (RIBE) has important implications for secondary cancer risk assessment during cancer radiotherapy, but the bystander signaling processes, especially under hypoxic condition, are still largely unclear. The present study found that micronuclei (MN) formation could be induced in the non-irradiated HL-7702 hepatocyte cells after being treated with the conditioned medium from irradiated hepatoma HepG2 and SK-Hep-1 cells under either normoxia or hypoxia. This bystander response was dramatically diminished or enhanced when the SirT1 gene of irradiated hepatoma cells was overexpressed or knocked down, respectively, especially under hypoxia. Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation. But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference. Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion. These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved.

  18. SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation

    International Nuclear Information System (INIS)

    Xie, Yuexia; Tu, Wenzhi; Zhang, Jianghong; He, Mingyuan; Ye, Shuang; Dong, Chen; Shao, Chunlin

    2015-01-01

    Highlights: • γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells. • SirT1 played a protective role in regulating this bystander effect. • SirT1 contributed to the protective effects via elimination the accumulation of ROS. • The activity of c-Myc is critical for maintaining the protective role of SirT1. - Abstract: Radiation-induced bystander effect (RIBE) has important implications for secondary cancer risk assessment during cancer radiotherapy, but the bystander signaling processes, especially under hypoxic condition, are still largely unclear. The present study found that micronuclei (MN) formation could be induced in the non-irradiated HL-7702 hepatocyte cells after being treated with the conditioned medium from irradiated hepatoma HepG2 and SK-Hep-1 cells under either normoxia or hypoxia. This bystander response was dramatically diminished or enhanced when the SirT1 gene of irradiated hepatoma cells was overexpressed or knocked down, respectively, especially under hypoxia. Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation. But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference. Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion. These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved

  19. Predicting changes in reported notifiable disease rates for New Zealand using a SIR modelling approach

    Science.gov (United States)

    McBride, Graham; Slaney, David; Tait, Andrew

    2013-04-01

    The New Zealand health system has defined as 'notifiable' over 50 diseases. Of these campylobacteriosis is the most commonly reported comprising 41% of all notifications in 2011 (presently about 150 illness cases per 100,000 population per annum). Furthermore, the incidence of this mild illness, which is potentially waterborne, is under-reported by at least an order-of-magnitude. Increased downstream pathogen loads and/or disease incidence have been found to be associated with increased rainfall, particularly in agricultural landscapes. Therefore, given the predominance of agricultural land uses in New Zealand, transmission and exposure to its agent (thermotolerant Campylobacter bacteria) may be affected by changing rainfall and temperature patterns associated with climate change. Reporting rates for other potentially water-borne zoonoses are also noticeable (for example, the reported rate for cryptosporidiosis for 2011 was 14 per 100,000 population). The distribution of Cryptosporidium oocysts in the environment may be influenced by climate change because it has often been implicated in drinking-water contamination, and heavy rainfall events have been found to be associated with increased pathogen loads in rivers and disease incidence. Given this background, which may also be applicable to other countries with agriculturally-dominated landscapes, a New Zealand study was initiated to develop a decision-support system for the projected effects of climate change on a selected suite of environmentally-transmitted pathogens, including Campylobacter and Cryptosporodium oocysts. Herein we report on the manner in which a linear SIR (Susceptible-Ill-Recovered) model previously developed for campylobacteriosis can be extended to cryptosporidiosis, applied to changes in pathogen contact rate and hence reported illness, and coupled to climate change projections associated with different greenhouse gas emission scenarios. The resulting SIR model outputs provided projected

  20. Another Look at a Bahamian Mystery: The Murder of Sir Harry Oakes

    Directory of Open Access Journals (Sweden)

    LeGrand, Cathy

    2010-01-01

    Full Text Available Stop me if you've heard this one:The richest man in the Bahamas, no, the richest man in the British empire, is murdered in his bed. He has suffered a fatal head wound caused by a boat's winch lever. Or by bullets from a small-caliber gun. No, by a conch shell. Or by some blunt object close at hand, still unidentified.The rich man's body is set afire in order to burn down his house and conceal the details of the crime. Or as a diversionary tactic, to confuse the authorities. No, in a voodoo ritual.The killer is his son-in-law. Or his houseguest. Or a mafia hitman.The reason for the murder: to eliminate a powerful opponent of casino gambling. Or to prevent this rich man from leaving the Bahamas with his businesses and wealth. Or to avenge the rich man's resentment of his daughter's choice of husband. Or to steal the enormous horde of gold reported to be hidden in his house.The richest man in the Bahamas (if not the whole Empire was Sir Harry Oakes, who earned his fortune from gold prospecting and spent the rest of his life avoiding the tax man. He was found murdered in the morning of 8 July 1943, having been killed sometime after midnight during a summer thunderstorm. His body, bearing four lethal head wounds and burns from the fire, was discovered the next morning by his close friend and houseguest, Harold Christie, an influential Bahamian estate agent.Add to this cast of characters a smooth-operating Mauritian (Alfred de Marigny married to Oakes' young daughter; a former King of England (the Duke of Windsor, now forced to serve this tiny colonial outpost; and the Duke's scandalous wife (the Duchess of Windsor, for whom he renounced his crown.Also, factor in the war raging around the globe. France had recently fallen to the Nazis; German U-boats patrolled the Atlantic; and the shortages and other exigencies of wartime were the rule. The trial of Alfred deMarigny, Oakes' son-in-law, made international news and his eventual acquittal left the case

  1. Sir Kenelm Digby (1603-1665): diplomat, entrepreneur, privateer, duellist, scientist and philosopher.

    Science.gov (United States)

    Mellick, Sam A

    2011-12-01

    Kenelm Digby was a man with widely differing interests. He studied at Oxford but left without a degree. At the age of 20, he was involved in a dramatic street brawl in Madrid; the following year saw him as a successful privateer in the Mediterranean and adjacent Atlantic waters, and he was then appointed a naval administrator with lucrative trade monopolies. He practised medicine without formal qualifications and gained notoriety by promoting the use of 'sympathetic' powder for healing wounds. Befriended by King James I and his son who succeeded him, he became chancellor to Queen Henrietta and was knighted by King James I on 21 October 1623 and appointed to the Privy Council. At one time, he even spent a brief time in prison, but he later became a founding member of the Royal Society and published two major philosophical treatises as well as a popular cookbook. He designed and manufactured wine bottles with tapered necks for simpler pouring and square sides for easy stacking. He dabbled in mathematics and corresponded with Fermat of 'Last Theorem' fame. In 1641, he challenged a French nobleman who publicly cast a slur on the British King to a 'digladiation' (a sword duel) and quickly dispatched him. He was a friend and admirer of Sir Thomas Browne whose 'Religio Medici' he helped to publish. The Cowlishaw Library holds a 1659 5th edition copy of this remarkable book, with Digby's name on the spine. Truly, Digby must qualify as a Renaissance man. © 2011 The Author. ANZ Journal of Surgery © 2011 Royal Australasian College of Surgeons.

  2. American views of Sir Victor Horsley in the era of Cushing.

    Science.gov (United States)

    Lehner, Kurt R; Schulder, Michael

    2018-03-09

    Sir Victor Horsley was a pioneering British neurosurgeon known for his numerous neurosurgical, scientific, and sociopolitical contributions. Although word of these surgical and scientific achievements quickly spread throughout Europe and North America in the late 19th century, much of modern neurosurgery's view of Horsley has been colored by a single anecdote from John Fulton's biography of Harvey Cushing. In this account, Cushing observes a frenetic Horsley hastily removing a Gasserian ganglion from a patient in the kitchen of a British mansion. Not long after, Cushing left Britain saying that he had little to learn from British neurosurgery. The authors of this paper examined contemporary views of Horsley to assess what his actual reputation was in the US and Canada. The authors conducted a thorough search of references to Horsley using the following sources: American surgical and neurosurgical textbooks; major biographies; diary entries and letters; PubMed; newspaper articles; and surgical and neurosurgical texts. The positive reception of his work is corroborated by invitations for Horsley to speak in America. Research additionally revealed that Horsley had numerous personal and professional relationships with prominent Americans in medicine, including William Osler, John Wheelock Elliot, Ernest Sachs, and (yes) Harvey Cushing. Horsley's contributions to medicine and science were heavily reported in American newspapers; outside of neurosurgery, his strong opposition to the antivivisectionists and his support for alcohol prohibition were widely reported in popular media. Horsley's contributions to neurosurgery in America are undeniable. Writings from and about prominent Americans reveal that he was viewed favorably by those who had met him. Frequent publication of his views in the American media suggests that medical professionals and the public in the US valued his contributions on scientific as well as social issues. Horsley died too young, but not without the

  3. Frequency Analysis Using Bootstrap Method and SIR Algorithm for Prevention of Natural Disasters

    Science.gov (United States)

    Kim, T.; Kim, Y. S.

    2017-12-01

    The frequency analysis of hydrometeorological data is one of the most important factors in response to natural disaster damage, and design standards for a disaster prevention facilities. In case of frequency analysis of hydrometeorological data, it assumes that observation data have statistical stationarity, and a parametric method considering the parameter of probability distribution is applied. For a parametric method, it is necessary to sufficiently collect reliable data; however, snowfall observations are needed to compensate for insufficient data in Korea, because of reducing the number of days for snowfall observations and mean maximum daily snowfall depth due to climate change. In this study, we conducted the frequency analysis for snowfall using the Bootstrap method and SIR algorithm which are the resampling methods that can overcome the problems of insufficient data. For the 58 meteorological stations distributed evenly in Korea, the probability of snowfall depth was estimated by non-parametric frequency analysis using the maximum daily snowfall depth data. The results show that probabilistic daily snowfall depth by frequency analysis is decreased at most stations, and most stations representing the rate of change were found to be consistent in both parametric and non-parametric frequency analysis. This study shows that the resampling methods can do the frequency analysis of the snowfall depth that has insufficient observed samples, which can be applied to interpretation of other natural disasters such as summer typhoons with seasonal characteristics. Acknowledgment.This research was supported by a grant(MPSS-NH-2015-79) from Disaster Prediction and Mitigation Technology Development Program funded by Korean Ministry of Public Safety and Security(MPSS).

  4. "The casual cruelty of our prejudices": on Walter Lippmann's theory of stereotype and its "obliteration" in psychology and social science.

    Science.gov (United States)

    Bottom, William P; Kong, Dejun Tony

    2012-01-01

    Reflecting on his wartime government service, Walter Lippmann (1922) developed a theory of policy formulation and error. Introducing the constructs of stereotype, mental model, blind spots, and the process of manufacturing consent, his theory prescribed interdisciplinary social science as a tool for enhancing policy making in business and government. Lippmann used his influence with the Rockefeller foundations, business leaders, Harvard and the University of Chicago to gain support for this program. Citation analysis of references to "stereotype" and Lippmann reveals the rapid spread of the concept across the social sciences and in public discourse paralleled by obliteration by incorporation of the wider theory in behavioral science. "Stereotype" is increasingly invoked in anthropology, economics, and sociology though Lippmann and his wider theory ceased being cited decades ago. In psychology, citations are increasing but content analysis revealed blind spots and misconceptions about the theory and prescription. Studies of heuristics, biases, and organizational decision substantiate Lippmann's theory of judgment and choice. But his model for social science failed to consider the bounded rationality and blind spots of its practitioners. Policy formulation today is supported by research from narrow disciplinary silos not interdisciplinary science that reflects an awareness of history. © 2012 Wiley Periodicals, Inc.

  5. Monoterpenoids from the traditional North Italian vegetable Aruncus dioicus (Walter) Fernald var. vulgaris (Maxim.) H.Hara (Rosaceae).

    Science.gov (United States)

    Granica, Sebastian; Fusani, Pietro; Stanisławska, Iwona; Piwowarski, Jakub P; Melck, Dominique; Motta, Andrea; Zidorn, Christian

    2017-04-15

    Investigations of young shoots of Aruncus dioicus (Walter) Fernald var. vulgaris (Maxim.) H.Hara (Rosaceae), collected from the wild and used as vegetables in alpine provinces of Italy, yielded eight monoterpenoids. Besides known compounds, aruncin A, aruncide A, and cimicifugolide, five previously undescribed substances, aruncins C, D, and E, and aruncides D and E, were identified. Based on results from the full synthesis of aruncin B, structures of aruncin A and aruncide A were revised. Structures were established by HR mass spectrometry and extensive 1D and 2D NMR spectroscopy and based on data from synthetic aruncin B. An HPLC-DAD-ESI-MS method was developed to investigate the distribution of the monoterpenoids in different organs of Aruncus dioicus var. vulgaris and in aerial parts of A. dioicus var. aethusifolius (H.Lév.) H.Hara [Syn.: Aruncus aethusifolius (H.Lév.) Nakai]. Preliminary bioactivity studies moreover indicated weak cytotoxicity for some of the compounds against human prostrate adenocarcinoma cells. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. NATURALIZAÇÃO DA DESIGUALDADE NO BRASIL: UM DIÁLOGO COM CARL SCHMITT, WALTER BENJAMIN E GIORGIO AGAMBEN

    Directory of Open Access Journals (Sweden)

    Bruna da Penha de Mendonça Coelho

    2017-10-01

    Full Text Available O artigo estabelece um diálogo entre as teorias de Carl Schmitt, Walter Benjamin e Giorgio Agamben, transpondo-as para a realidade social brasileira. A naturalização da desigualdade constitui marca cruel de nossa sociedade, e a filosofia do direito contribui para uma abordagem jurídica que leva em conta as disparidades sociais. Far-se-á, primeiramente, uma análise do estado de exceção à luz das obras de Benjamin e Agamben. Posteriormente, com Schmitt, a questão da exceção será analisada em conjunto com a decisão política, demonstrando a ligação intrínseca entre direito e política e o reflexo disto no agravamento das desigualdades sociais. Será estabelecida a diferença entre os conceitos de “inimigo”, de Schmitt, e homo sacer, de Agamben, na instauração do estado de exceção e como o conceito de “inimigo” foi desvirtuado com a construção da Teoria do Direito Penal do Inimigo.

  7. Bora Bora, Tahaa, and Raiatea, French Polynesia, Landsat and SIR-C Images Compared to SRTM Shaded

    Science.gov (United States)

    2005-01-01

    Bora Bora, Tahaa, and Raiatea (top to bottom) are Polynesian Islands about 220 kilometers (135 miles) west-northwest of Tahiti in the South Pacific. Each of the islands is surrounded by a coral reef and its associated islets ('motus') that enclose a lagoon. Actually, as seen here, Tahaa and Raiatea are close enough together to share a common lagoon and reef. These islands are volcanic in origin and were built up from the sea floor by lava extrusions millions of years ago. None is now active, and all are deeply eroded. This display compares three differing 'views from space' of these islands. On the left, an image from the Landsat 7 satellite shows the islands as they might have appeared to an astronaut in orbit in 1999 (but a little sharper and with atmospheric haze suppressed). In the middle is an image created from data gathered by the third-generation Shuttle Imaging Radar (SIR-C), flown in 1994. On the right is a graphic illustrating elevation data gathered by the Shuttle Radar Topography Mission (SRTM) in 2000. Each of these images shows very different information as compared to the other two. Landsat sees clouds, which are almost always above these islands, blocking the view of the terrain. It also readily sees through shallow water down to the reefs. SIR-C sees the waves and other effects of winds upon the ocean surface. It does not look through water to see the reefs, but it clearly separates land and water. It also provides a bolder (but distorted) view of the islands' topographic patterns. With the ability of radar to see through clouds and provision of its own illumination, the SIR-C view is not limited by clouds nor their shadows. SRTM was designed to provide new information that is missing in the Landsat and SIR-C views. Specifically, SRTM created the world's first near-global, detailed elevation model. Natural topographic shading in Landsat imagery and radar topographic shadowing of SIR-C give some evidence of the shape of the ground but do not

  8. La Jolie Fille de Perth de Bizet  ou comment trahir et honorer Walter Scott Bizet’s Jolie Fille de Perth or How to Betray and Honour Walter Scott

    Directory of Open Access Journals (Sweden)

    Gilles Couderc

    2011-11-01

    Full Text Available What remains of Walter Scott’s Fair Maid of Perth in Bizet’s 1867 Jolie Fille de Perth, an opera in 4acts on a libretto by Jules Adenis and Vernoy de Saint-Georges? Not much when compared to other Scott-inspired operas. Little historical context or local colour, even in Bizet’s music. Some characters remotely linked to Scott in a libretto that mostly abides by the rules of French opera or opéra-comique of the time and recycles the dramatic ingredients favoured by Saint-Georges, a purveyor of libretti for opera or the ballet second only to Scribe, who engendered such international successes as Flotow’s Martha and Balfe’s Bohemian Girl, whose gipsy, long before his Carmen, haunts Bizet’s “Scottish” opera. Yet the work pays indirect homage to Scott, whose historical novels contributed to the birth of the French “grand opera”, by rewriting scenes or situations drawn from Scott. In spite of borrowing freely from French grand opera and opéra-comique, Bizet here attempts to find his own musical expression and his opera reflects aspects of Second Empire French society and the roles it assigned to women, before the appearance of his revolutionary Carmen on the stage.Que reste t’il du roman de Walter Scott The Fair Maid of Perth dans la Jolie Fille de Perth de Bizet, opéra en 4 actes de 1867 sur un livret de Vernoy de Saint-Georges, vieux routier du théâtre lyrique, et Jules Adenis ? Pas grand-chose par rapport aux opéras inspirés par Scott. Peu d’Ecosse, une absence remarquable de couleur locale ou historique, des personnages vaguement inspirés de Scott pour un livret qui se plie surtout aux règles de l’opéra français et de l’opéra-comique à la manière de Scribe et recycle les ingrédients habituels des livrets de Saint-Georges, père de succès internationaux comme la Martha de Flotow et de la Bohemian Girl de Balfe, dont la figure exotique de la bohémienne, longtemps avant Carmen, hante l’opéra

  9. Diversidade de Agaricales (Basidiomycota na Reserva Biológica Walter Egler, Amazonas, Brasil Diversity of Agaricales (Basidiomycota in the Reserva Biológica Walter Egler, Amazonas, Brazil

    Directory of Open Access Journals (Sweden)

    Helenires Queiroz de Souza

    2004-01-01

    Full Text Available Foi realizado um estudo dos representantes da Ordem Agaricales Clements (Hymenomycetes, Basidiomycotina, ocorrentes na Reserva Biológica Walter Egler, situada na Estrada AM-010, Manaus-Itacoatiara, Km 64, Latitude 02° 43' S e Longitude 59° 47' W, Rio Preto da Eva, Amazonas. A área abrange 709 ha de floresta de terra firme primária. As coletas foram realizadas no período de dezembro de 2000 a junho de 2001 e seguiu-se a metodologia usual para identificação de Agaricales. Foram estudadas um total de 39 espécies, distribuídas em 13 gêneros e seis famílias: Polyporaceae: Pleurotus sp.; Hygrophoraceae: Hygrocybe cf. megistospora, Hygrocybe aff. miniceps, Hygrocybe occidentalis var. scarletina, e mais oito espécies de Hygrocybe indeterminadas; Tricholomataceae: Clitocybe sp., Hydropus sp.1 e Hydropus sp.2, Macrocystidia sp., Marasmiellus sp., Marasmius bellus, Marasmius haedinus var. haedinus,Marasmius cf. leoninus, Marasmius cf. mazatecus, Marasmius cf. ruber,Marasmius cf. setulosifolius, Marasmius tageticolor, Marasmius cf. variabiliceps var. variabiliceps, Marasmius sp.1, Marasmius sp.2, Marasmius sp.3 e Marasmius sp.4, Tricholoma sp.; Agaricaceae: Agaricus sp.1 e Agaricus sp.2, Lepiota sp., Cystoderma sp.; Entolomataceae: Entoloma cf. azureoviride, Entoloma cf. cystidiophorum, Entoloma strigosissima, Entoloma sp.; Russulaceae: Lactarius panuoides. Destas, Entoloma azureoviride, Hygrocybe miniceps, Lactarius panuoides, Marasmius cf. mazatecus, Marasmius cf. setulosifolius e Marasmius variabiliceps var. variabiliceps, provavelmente, estão sendo aqui citadas pela primeira vez, para o Brasil. Com exceção de Marasmius tageticolor, as demais espécies são citadas pela primeira vez, para a Reserva Egler. São fornecidas tabelas com a ocorrência das espécies de acordo com o gradiente topográfico (baixio, vertente, platô e seus respectivos habitats.A study of the order Agaricales Clements (Hymenomycetes, Basidiomycotina, occurring in

  10. A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability.

    Directory of Open Access Journals (Sweden)

    Tânia Reis

    2010-11-01

    Full Text Available Obesity has a strong genetic component, but few of the genes that predispose to obesity are known. Genetic screens in invertebrates have the potential to identify genes and pathways that regulate the levels of stored fat, many of which are likely to be conserved in humans. To facilitate such screens, we have developed a simple buoyancy-based screening method for identifying mutant Drosophila larvae with increased levels of stored fat. Using this approach, we have identified 66 genes that when mutated increase organismal fat levels. Among these was a sirtuin family member, Sir2. Sirtuins regulate the storage and metabolism of carbohydrates and lipids by deacetylating key regulatory proteins. However, since mammalian sirtuins function in many tissues in different ways, it has been difficult to define their role in energy homeostasis accurately under normal feeding conditions. We show that knockdown of Sir2 in the larval fat body results in increased fat levels. Moreover, using genetic mosaics, we demonstrate that Sir2 restricts fat accumulation in individual cells of the fat body in a cell-autonomous manner. Consistent with this function, changes in the expression of metabolic enzymes in Sir2 mutants point to a shift away from catabolism. Surprisingly, although Sir2 is typically upregulated under conditions of starvation, Sir2 mutant larvae survive better than wild type under conditions of amino-acid starvation as long as sugars are provided. Our findings point to a Sir2-mediated pathway that activates a catabolic response to amino-acid starvation irrespective of the sugar content of the diet.

  11. Isonicotinamide Enhances Sir2 Protein-mediated Silencing and Longevity in Yeast by Raising Intracellular NAD+ Concentration*

    Science.gov (United States)

    McClure, Julie M.; Wierman, Margaret B.; Maqani, Nazif; Smith, Jeffrey S.

    2012-01-01

    Sirtuins are an evolutionarily conserved family of NAD+-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD+ concentration through the combined action of NAD+ biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD+ precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the nicotinamidase Pnc1 converts NAM to nicotinic acid (NA), which is then used as a substrate by the NAD+ salvage pathway enzyme NA phosphoribosyltransferase (Npt1). Isonicotinamide (INAM) is an isostere of NAM that stimulates yeast Sir2 deacetylase activity in vitro by alleviating the NAM inhibition. In this study, we determined that INAM stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD+ concentration. INAM enhanced normal silencing at the rDNA locus but only partially suppressed the silencing defects of an npt1Δ mutant. Yeast cells grown in media lacking NA had a short replicative life span, which was extended by INAM in a SIR2-dependent manner and correlated with increased NAD+. The INAM-induced increase in NAD+ was strongly dependent on Pnc1 and Npt1, suggesting that INAM increases flux through the NAD+ salvage pathway. Part of this effect was mediated by the NR salvage pathways, which generate NAM as a product and require Pnc1 to produce NAD+. We also provide evidence suggesting that INAM influences the expression of multiple NAD+ biosynthesis and salvage pathways to promote homeostasis during stationary phase. PMID:22539348

  12. Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.

    Science.gov (United States)

    McClure, Julie M; Wierman, Margaret B; Maqani, Nazif; Smith, Jeffrey S

    2012-06-15

    Sirtuins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD(+) concentration through the combined action of NAD(+) biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD(+) precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the nicotinamidase Pnc1 converts NAM to nicotinic acid (NA), which is then used as a substrate by the NAD(+) salvage pathway enzyme NA phosphoribosyltransferase (Npt1). Isonicotinamide (INAM) is an isostere of NAM that stimulates yeast Sir2 deacetylase activity in vitro by alleviating the NAM inhibition. In this study, we determined that INAM stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD(+) concentration. INAM enhanced normal silencing at the rDNA locus but only partially suppressed the silencing defects of an npt1Δ mutant. Yeast cells grown in media lacking NA had a short replicative life span, which was extended by INAM in a SIR2-dependent manner and correlated with increased NAD(+). The INAM-induced increase in NAD(+) was strongly dependent on Pnc1 and Npt1, suggesting that INAM increases flux through the NAD(+) salvage pathway. Part of this effect was mediated by the NR salvage pathways, which generate NAM as a product and require Pnc1 to produce NAD(+). We also provide evidence suggesting that INAM influences the expression of multiple NAD(+) biosynthesis and salvage pathways to promote homeostasis during stationary phase.

  13. The Herschel objects and how to observe them exploring sir William Herschel's star clusters, nebulae, and galaxies

    CERN Document Server

    Mullaney, James

    2007-01-01

    Deep-sky observers are always on the lookout for new observing challenges. "The Herschel Objects, and How to Observe them" offers an exciting opportunity to retrace the footsteps of Sir William Herschel, discoverer of Uranus and arguably the greatest visual observer and celestial explorer that ever lived!Following a biography of Herschel that details his life and the telescopes he used, this practical observer's guide lists all the most impressive of Herschel's star clusters, nebulae and galaxies.More than 600 of the brightest of the objects that Herschel observed are covered, and there are detailed descriptions and images of almost 200 of the very best Herschel objects for amateur astronomers.

  14. Photographic Standards for Patients With Facial Palsy and Recommendations by Members of the Sir Charles Bell Society.

    Science.gov (United States)

    Santosa, Katherine B; Fattah, Adel; Gavilán, Javier; Hadlock, Tessa A; Snyder-Warwick, Alison K

    2017-07-01

    There is no widely accepted assessment tool or common language used by clinicians caring for patients with facial palsy, making exchange of information challenging. Standardized photography may represent such a language and is imperative for precise exchange of information and comparison of outcomes in this special patient population. To review the literature to evaluate the use of facial photography in the management of patients with facial palsy and to examine the use of photography in documenting facial nerve function among members of the Sir Charles Bell Society-a group of medical professionals dedicated to care of patients with facial palsy. A literature search was performed to review photographic standards in patients with facial palsy. In addition, a cross-sectional survey of members of the Sir Charles Bell Society was conducted to examine use of medical photography in documenting facial nerve function. The literature search and analysis was performed in August and September 2015, and the survey was conducted in August and September 2013. The literature review searched EMBASE, CINAHL, and MEDLINE databases from inception of each database through September 2015. Additional studies were identified by scanning references from relevant studies. Only English-language articles were eligible for inclusion. Articles that discussed patients with facial palsy and outlined photographic guidelines for this patient population were included in the study. The survey was disseminated to the Sir Charles Bell Society members in electronic form. It consisted of 10 questions related to facial grading scales, patient-reported outcome measures, other psychological assessment tools, and photographic and videographic recordings. In total, 393 articles were identified in the literature search, 7 of which fit the inclusion criteria. Six of the 7 articles discussed or proposed views specific to patients with facial palsy. However, none of the articles specifically focused on

  15. Florence Nightingale (1820-1910) and Sir John Forbes (1787-1861): neighbours in Old Burlington Street, Westminster.

    Science.gov (United States)

    Agnew, Robin

    2015-05-01

    The year 2010 marks the centenary of the birth of Florence Nightingale and will, no doubt, be universally remembered. Her life and nursing career have recently been fully described by Bostridge. It is less well known that her neighbour from November 1856 was the distinguished Scottish physician Sir John Forbes MD Edin FRCP Lond FRS DCL Oxon. Although they never met, they exchanged copies of each other's books and shared a mutual respect. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  16. Dynamics of a stochastic delayed SIR epidemic model with vaccination and double diseases driven by Lévy jumps

    Science.gov (United States)

    Liu, Qun; Jiang, Daqing; Shi, Ningzhong; Hayat, Tasawar

    2018-02-01

    In this paper, we study the dynamics of a stochastic delayed SIR epidemic model with vaccination and double diseases which make the research more complex. The environment variability in this paper is characterized by white noise and Lévy noise. We establish sufficient conditions for extinction and persistence in the mean of the two epidemic diseases. It is shown that: (i) time delay and Lévy noise have important effects on the persistence and extinction of epidemic diseases; (ii) two diseases can coexist under certain conditions.

  17. The Use of Volunteers in Local Study Library Projects: A Case Study of the Walter Gardiner Photography Project

    Directory of Open Access Journals (Sweden)

    Beth Hewitt

    2012-03-01

    Full Text Available Objectives – Interviews with library staff and volunteers were conducted to evaluate the use of volunteers in UK public libraries via a case study of the Walter Gardiner Photographic Project, a digitisation project based in Worthing Library, to inform future guidelines on volunteer usage and to make recommendations to existing practice.Methods – Fourteen semi-structured interviews were carried out to explore the perceptions and experiences of both staff and volunteers of the project. All interviews were fully transcribed and then coded to identify emergent themes.Results – Key positives for volunteers were professional training, good time management and organization by staff, the friendliness and approachability of staff, and the informal nature of the volunteering. Enjoyment of the work and forming close relationships with others were key motivating factors. For staff, the completion of work which would have otherwise been impossible was the most positive outcome. Problem areas identified by volunteers were lack of contact time with project staff and feeling isolated from other library staff. For project staff, a lack of professionalism on behalf of some volunteers was the primary negative. Key issues to emerge were the need to strike a balance between formal and informal management, the need for good integration between the volunteers and host organization, and the importance of acknowledging the nature of the voluntary commitment.Conclusions – The project proved overall to be a successful example of using volunteers in public library projects with good examples of volunteer recruitment, training, and management being demonstrated. Areas of conflict that did arise stemmed from differing expectations of levels of service between staff and volunteers. Clarification on these expectations through a written volunteer agreement is advocated for further projects.

  18. Social individualism: Walter Gropius and his appropriation of Franz Müller-Lyer's idea of a new man.

    Science.gov (United States)

    Poppelreuter, Tanja

    2011-01-01

    In 1929, Walter Gropius developed the "High-Rise Steel Frame Apartment Building" that was based on theories about the emergence of a New Man put forward by sociologist Franz Müller-Lyer. In his lecture at the Congrès International d’Architecture Moderne conference in 1929, Gropius appropriated Müller-Lyer's sociology in order to promote and prompt the re-development of high-rise tenements and master households. Gropius’ 1931 contribution to the Deutsche Bauausstellung in Berlin incorporated a full-scale community lounge and a recreation area with sporting equipment, as well as a model and plans for a "High-Rise Steel Frame Apartment Building" that were designed in accordance with Müller-Lyer's theories. While it shows Müller-Lyer's influence, the boxing equipment found in the recreation area reflects the importance that sport, and boxing in particular, had gained after 1900. Boxing was perceived as a sport that would not only further fitness but also raise the spirits and help the inhabitant to succeed in the modern urban environment. By providing boxing equipment, Müller-Lyer's vision, which envisaged master households as furthering a community of peaceful individuals living in a condition of mutual trust, is weakened. In 1923, the sociologist Helmuth Plessner had regarded utopian visions of ideal communities as antithesis to actual events in the Weimar Republic. The embracing of theories that promised an evolutionary and linear development towards peaceful communities can be regarded as a counterreaction to a present that was perceived as an imperfect and temporary condition. Furthermore, Gropius’ appropriation of Müller-Lyer's sociology not only helped to distinguish his position from Marxist and socialist theories but also illustrated the contemporary tendency to accept utopian ideas while simultaneously doubting the practicality of some.

  19. RACISMO PRESENTE NA ANIMAÇÃO “SCRUB ME MAMA WITH A BOGGIE BEAT” DE WALTER LANTZ (1941

    Directory of Open Access Journals (Sweden)

    Julio Geraldo Carvalho de Jesus

    2017-01-01

    Full Text Available As Animações são fontes interessantes de serem exploradas pela perspectiva histórica, uma vez que trazem questões impostas pelo contexto da produção e podem ser utilizadas como meio de transmitir conhecimentos e ideologias. O presente artigo faz uma reflexão acerca do tema do racismo nas animações dirigidas e produzidas por Walter Lantz, no ano de 1941, tomando como base o cartoon “Scrube Me Mama with a Boogie Beat”, distribuído pela Universal Studios, e reexibido no ano de 1948. Apesar do racismo presente na obra, não há qualquer menção crítica ao filme, na época em que foi lançado, o que nos permitiu estabelecer um paralelo entre a animação de Lantz e a alegoria do açougue apresentada por Serguei Eisenstein no filme “A greve”. No filme de Eisenstein, a cena final mostra um boi sendo degolado. A violência da cena causou grande impacto na população urbana, mas não impactou da mesma forma os habitantes da zona rural, acostumados com a prática. Da mesma forma, a obra de Lantz, permeada de traços racistas, não causou indignação na população negra, sobretudo por ser comum dentro da sociedade norte americana da época.

  20. Sir Harold Delf Gillies, the otolaryngologist and father of modern facial plastic surgery: review of his rhinoplasty case notes.

    Science.gov (United States)

    Spencer, C R

    2015-06-01

    Sir Harold Gillies, born in New Zealand, is widely considered a British icon and the father of modern plastic surgery. This article provides an overview of his life and the circumstances which led to him laying the foundations of plastic surgery in Britain in the early twentieth century. A hand search and review of case notes from the Gillies Archives at Queen Mary's Hospital in Sidcup, UK, where he made history, was conducted. Gillies' ongoing legacy was found to also include his influence on the development of his cousin Sir Archibald McIndoe's work. Gillies was a talented sportsman who engaged in charitable activities. Additionally, he was a gifted teacher, with his hospital attracting many young surgeons from around the world. He was found to have expressed genius in both the design and execution of the art and science of surgery. He incepted reconstructive techniques ranging from the world's first gender reassignment operation to facial reanimation procedures for the treatment of facial paralysis. His operative work on ex-servicemen in need of complex rhinoplasty and in particular the inception of the tubed pedicle flap are depicted.

  1. Law of large numbers for the SIR model with random vertex weights on Erdős-Rényi graph

    Science.gov (United States)

    Xue, Xiaofeng

    2017-11-01

    In this paper we are concerned with the SIR model with random vertex weights on Erdős-Rényi graph G(n , p) . The Erdős-Rényi graph G(n , p) is generated from the complete graph Cn with n vertices through independently deleting each edge with probability (1 - p) . We assign i. i. d. copies of a positive r. v. ρ on each vertex as the vertex weights. For the SIR model, each vertex is in one of the three states 'susceptible', 'infective' and 'removed'. An infective vertex infects a given susceptible neighbor at rate proportional to the production of the weights of these two vertices. An infective vertex becomes removed at a constant rate. A removed vertex will never be infected again. We assume that at t = 0 there is no removed vertex and the number of infective vertices follows a Bernoulli distribution B(n , θ) . Our main result is a law of large numbers of the model. We give two deterministic functions HS(ψt) ,HV(ψt) for t ≥ 0 and show that for any t ≥ 0, HS(ψt) is the limit proportion of susceptible vertices and HV(ψt) is the limit of the mean capability of an infective vertex to infect a given susceptible neighbor at moment t as n grows to infinity.

  2. Sawtooth events and O+ in the plasma sheet and boundary layer: CME- and SIR-driven events

    Science.gov (United States)

    Lund, E. J.; Nowrouzi, N.; Kistler, L. M.; Cai, X.; Liao, J.

    2017-12-01

    The role of ionospheric ions in sawtooth events is an open question. Simulations[1,2,3] suggest that O+ from the ionosphere produces a feedback mechanism for driving sawtooth events. However, observational evidence[4,5] suggest that the presence of O+ in the plasma sheet is neither necessary nor sufficient. In this study we investigate whether the solar wind driver of the geomagnetic storm has an effect on the result. Building on an earlier study[4] that used events for which Cluster data is available in the plasma sheet and boundary layer, we perform a superposed epoch analysis for coronal mass ejection (CME) driven storms and streaming interaction region (SIR) driven storms separately, to investigate the hypothesis that ionospheric O+ is an important contributor for CME-driven storms but not SIR-driven storms[2]. [1]O. J. Brambles et al. (2011), Science 332, 1183.[2]O. J. Brambles et al. (2013), JGR 118, 6026.[3]R. H. Varney et al. (2016), JGR 121, 9688.[4]J. Liao et al. (2014), JGR 119, 1572.[5]E. J. Lund et al. (2017), JGR, submitted.

  3. sir, besoin, dépendance : l'addiction comme (épreuve de la modernité

    Directory of Open Access Journals (Sweden)

    Rita Di Lorenzo

    2016-04-01

    Full Text Available La frontière entre la santé et la pathologie est un lieu fascinant et dangereux, au caractère poreux et riche de familiarités des deux côtés, inavouées et coûteuses. Le terme d’addiction semble s’installer précisément sur cette frontière, gagnant en étendue médiatique ce qu’il perd en précision nosographique ; ainsi, aujourd’hui, nous serions « tous addicts » – au sucre, au téléphone portable, au chocolat, au café, aux soldes, à la chirurgie esthétique, à Facebook, à l’amour, cette liste pouvant être continuée par chacun d’entre nous puisque nous avons tous fait, nous faisons et ferons tous, l’expérience de la force des (mauvaises habitudes, du désir, voire de la pulsion, de l’abus et de la dépendance. Notre société contemporaine semble stimuler cette expérience, en multipliant tant les objets addictogènes que les comportements addictifs : d’une part par le statut attribué aux biens sériels, d’autre part par la dimension pulsionnelle revendiquée dans les habitudes de consommation. Société du plaisir, peut-être plus hédoniste qu’épicurienne, l’époque contemporaine impose le plaisir et son désir comme nouvelle norme. Dès lors, quel est notre rapport à la pulsion, au désir compulsif, au dépassement des limites imposées aux besoins et aux envies socialement acceptables ? Comment notre société régule le désir ? Comment la politique et les médias concourent-ils à le structurer, voire à le prescrire ? Quels mécanismes à l’œuvre dans l’addiction contredisent cette prescription, et surtout : s’agit-il véritablement d’une contradiction ? Notre culture de performance et satisfaction rapides peut effectivement expliquer certaines dépendances induites par leur objet ; néanmoins, la véritable addiction mentale se nourrit d’éléments plus profondément constitutifs de l’identité de l’homme moderne et contemporain : avant tout, la fragilité des acquis, la

  4. Arte, imagem e fotografia: um diálogo possível entre Roland Barthes, Walter Benjamin e Jacques Rancière = Art, image and photography: a possible dialogue between Roland Barthes, Walter Benjamin and Jacques Rancière

    Directory of Open Access Journals (Sweden)

    Voigt, André Fabiano

    2016-01-01

    Full Text Available O presente artigo objetiva estabelecer um diálogo entre três autores que escreveram trabalhos importantes sobre a relação da arte com as imagens e a fotografia. Enquanto os pensamentos de Roland Barthes e Walter Benjamin se assemelham, Jacques Rancière apresenta uma postura dissonante ao analisar arte, imagem e fotografia no interior do que ele chama de regime estético das artes

  5. Estruturas de sentimento na modernidade: um estudo sobre as experiências nas obras de Walter Benjamin, a propósito de Charles Baudelaire

    Directory of Open Access Journals (Sweden)

    Fabíola Calazans

    2011-01-01

    Full Text Available A partir da noção de “estruturas de sentimento” do pensador do materialismocultural Raymond Williams, pretende-se estudar as experiências tecnológicas perceptivas nacultura moderna, do século XIX, imanentes às obras de Walter Benjamin, particularmente,nos textos referentes a Charles Baudelaire. Para tanto, faz-se um estudo exploratório dasprincipais categorias de experiência para se compreender as implicações na modernidade.

  6. Children’s Hospital of Pittsburgh and Diabetes Institute of the Walter Reed Health Care System Genetic Screening in Diabetes: Candidate Gene Analysis for Diabetic Retinopathy

    Science.gov (United States)

    2010-05-01

    Screening in Diabetes : Candidate Gene Analysis for Diabetic Retinopathy PRINCIPAL INVESTIGATOR: Robert A. Vigersky, COL MC CONTRACTING ORGANIZATION... Diabetes Institute of the Walter Reed Health Care System Genetic Screening in Diabetes : Candidate Gene Analysis for Diabetic Retinopathy 5c. PROGRAM... diabetic  neuropathy, and  diabetic   retinopathy .  This was an observational study in which the investigators obtained DNA samples from the blood of

  7. “Speaking German Like Nobody’s Business”: Anna May Wong, Walter Benjamin, and the Possibilities of Asian American Cosmopolitanism

    OpenAIRE

    Lim, Shirley Jennifer

    2012-01-01

    In the summer of 1928 in Berlin, the noted German Jewish philosopher Walter Benjamin (1892–1940) and Chinese American actress Anna May Wong (1905–1961) shared an unlikely encounter that set in relief European and American conceptions of modernity as well as white European intellectual and American racial minority cosmopolitanisms. On July 6, 1928, Benjamin published the results as “Gespräch mit Anne May Wong” [“Speaking with Anna May Wong: A Chinoiserie from the Old West”] on the front page o...

  8. Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively.

    Directory of Open Access Journals (Sweden)

    Inbal Nussbaum

    Full Text Available Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood, although deteriorated stress response is one of the hallmarks of aging. The budding yeast Saccharomyces cerevisiae is a valuable model organism to study the genetics of aging, because yeast ages within days and are amenable to genetic manipulations. As a unicellular organism, yeast has evolved robust systems to respond to environmental challenges. This response is orchestrated largely by the conserved transcription factor Hsf1, which in S. cerevisiae regulates expression of multiple genes in response to diverse stresses. Here we demonstrate that Hsf1 response to heat shock and oxidative stress deteriorates during yeast transition from exponential growth to stationary-phase, whereas Hsf1 activation by glucose starvation is maintained. Overexpressing Hsf1 does not significantly improve heat shock response, indicating that Hsf1 dwindling is not the major cause for Hsf1 attenuated response in stationary-phase yeast. Rather, factors that participate in Hsf1 activation appear to be compromised. We uncover two factors, Yap1 and Sir2, which discretely function in Hsf1 activation by oxidative stress and heat shock. In Δyap1 mutant, Hsf1 does not respond to oxidative stress, while in Δsir2 mutant, Hsf1 does not respond to heat shock. Moreover, excess Sir2 mimics the heat shock response. This role of the NAD+-dependent Sir2 is supported by our finding that supplementing NAD+ precursors improves Hsf1 heat shock response in stationary-phase yeast, especially when combined with expression of excess Sir2. Finally, the combination of excess Hsf1, excess Sir2 and NAD+ precursors rejuvenates the heat shock response.

  9. Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively.

    Science.gov (United States)

    Nussbaum, Inbal; Weindling, Esther; Jubran, Ritta; Cohen, Aviv; Bar-Nun, Shoshana

    2014-01-01

    Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood, although deteriorated stress response is one of the hallmarks of aging. The budding yeast Saccharomyces cerevisiae is a valuable model organism to study the genetics of aging, because yeast ages within days and are amenable to genetic manipulations. As a unicellular organism, yeast has evolved robust systems to respond to environmental challenges. This response is orchestrated largely by the conserved transcription factor Hsf1, which in S. cerevisiae regulates expression of multiple genes in response to diverse stresses. Here we demonstrate that Hsf1 response to heat shock and oxidative stress deteriorates during yeast transition from exponential growth to stationary-phase, whereas Hsf1 activation by glucose starvation is maintained. Overexpressing Hsf1 does not significantly improve heat shock response, indicating that Hsf1 dwindling is not the major cause for Hsf1 attenuated response in stationary-phase yeast. Rather, factors that participate in Hsf1 activation appear to be compromised. We uncover two factors, Yap1 and Sir2, which discretely function in Hsf1 activation by oxidative stress and heat shock. In Δyap1 mutant, Hsf1 does not respond to oxidative stress, while in Δsir2 mutant, Hsf1 does not respond to heat shock. Moreover, excess Sir2 mimics the heat shock response. This role of the NAD+-dependent Sir2 is supported by our finding that supplementing NAD+ precursors improves Hsf1 heat shock response in stationary-phase yeast, especially when combined with expression of excess Sir2. Finally, the combination of excess Hsf1, excess Sir2 and NAD+ precursors rejuvenates the heat shock response.

  10. Karl Rahner, Walter Kasper and Hans Kung on the Current State, Problems and Dimensions of Contemporary theology

    Directory of Open Access Journals (Sweden)

    Pilipenko Evgenii

    2017-06-01

    Full Text Available Political history, philosophy, culture and science of the 19th century came to be very important factors in the development of Christian theology, primarily in Western Europe. Major issues of correlation between modern science, philosophical concepts of the modern period, secular ethics and Christianity led to a revision of many traditional theological concepts. There were suggested new methods of solving urgent theological, pastoral and missionary problems. The Second Vatican Ecumenical Council of Roman Catholic Church represented a vivid and constructive response to contemporary challenges. German theologians were among those who contributed significantly to the dialogue between the Church and modern world. The central fi gure among them was Karl Rahner. Using achievements of modern European thought, especially transcendental and existential philosophy, Rahner made Christian theology tenable for modern historical criticism and placed the person and the experience of faith as a crucial object of theological investigation. It may seem a paradox, but the unity of Catholic dogma in the 20th century came to be established not on the unity of the formal scholastic doctrine, proclaimed straightforwardly by Church magisterium, but on theological pluralism and historical dynamism, as well as on hermeneutical analysis of the dogma and inexpressible mystical experience of Revelation proclaimed by Rahner. Walter Kasper used Rahner’s ideas when he pointed to scientific rigour, ecclesiasticism and willingness to be opened to the world as main features of modern theology. At the same time, he considers it impossible to reject metaphysics and to reduce theology to a number of disparate academic studies. He sees the Holy Scriptures and church tradition as the essential foundation for systematic theology and argues that it is necessary to restore the balance between the freedom of theological investigation and the hierarchical control of Church magisterium

  11. Walter Pater's "Winckelmann"

    Science.gov (United States)

    Carrier, David

    2001-01-01

    In his recent book, "The Art of Living: Socratic Reflections from Plato to Foucault," Alexander Nehamas presents two conceptions of philosophy--philosophy as a theorethical discipline concerned to offer arguments; and the interest of Socrates, Montaigne, and also Nietzsche and Foucault in the art of living. Building on his "Nietzsche: Life as…

  12. Le continent noir du désir masculin : Colet et Flaubert, encore

    Directory of Open Access Journals (Sweden)

    Barbara Vinken

    2010-09-01

    Full Text Available Il y a peu d’échanges de lettres qui surprennent le lecteur aussi douloureusement que celui entre Louise Colet et Gustave Flaubert. Rarement, l’espoir qui sommeille au fond de tout lecteur d’une histoire d’amour heureux fut à ce point frustré.Les études de Freud – un des plus grands sceptiques en matière d’amour – sur la vie sexuelle éclairent les vicissitudes du désir amoureux masculin. Les Lettres de Flaubert à Colet sont la mise en scène dramatique d’un désir qui suit les complications du scénario fétichiste. L’investissement de l’objet fétiche – les pantoufles, à savoir les pantoufles dans lesquelles est enfoncé un mouchoir de Colet, taché de sang, et dont Flaubert se sert pour se masturber – n’est que le symptôme le plus évident, pour ainsi dire clinique, de cette disposition fétichiste. La masturbation, liée au fétichisme du pied et de la chaussure fut, selon ses lettres, la pratique sexuelle la plus satisfaisante pour Flaubert.Inscrit dans les pantoufles est le drame de la castration, façon enfantine d’interpréter la différence sexuelle. D’un côté, les pantoufles sont ce que l’enfant voit avant de s’apercevoir du manque du pénis maternel. Les pantoufles, fétiche on ne peut plus classique, prennent par un déplacement métonymique la place du phallus maternel, dont l’absence est constatée avec horreur. C’est ce manque qui fait que le garçon réalise la possibilité de la castration. L’objet fétiche est à la fois mémoire de et triomphe sur la castration. Le fétiche de Flaubert porte les marques de la castration : les taches de sang. Elles sont en même temps témoignage de et écran devant la blessure. Rien n’excite Flaubert tant que ces pantoufles, qui sont à la fois déni (Verleugnung et constat de la castration : le fétichiste, écrit Freud, ne fait pas qu’adorer le fétiche. Souvent la castration est inscrite dans l'objet.Son incapacité d

  13. L’ontologie des Indivisibles et la structure du continu selon Gautier Burley The ontology of Indivisibles and the structure of continuity according to Walter Burley

    Directory of Open Access Journals (Sweden)

    Alice Lamy

    2011-12-01

    Full Text Available Pour Aristote, sous le rapport de sa composition en parties, le continu est divisible mais sous le rapport de ses limites (point, ligne, surface et profondeur, le continu est indivisible. Walter Burley, comme ses contemporains, a commenté la coexistence problématique de la divisibilité et de l’indivisibilité dans la structure du continu. Bien plus, aux prises avec sa célèbre polémique contre son adversaire Guillaume d’Ockham à propos de l’ontologie de la catégorie de quantité, il admet une structure du continu originale qui semble contenir à la fois des intervalles ou parties divisibles et des points ou indivisibles.For Aristote, concerning its composition in parts, the continuous is divisible but concerning its limits (point, line, surface and depth, the continuous is indivisible. Walter Burley, as his contemporaries, commented on the problematic coexistence of the divisibility and the indivisibility in the structure of the continuous. Much more, battling against his opponent Wilhelm of Ockham about the ontology of the category of quantity, he admits an original structure of continuous who seems to contain at the same time intervals or divisible parts and indivisible points.

  14. The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from Narcissus 'Sir Winston Churchill'

    NARCIS (Netherlands)

    Ingkaninan, K.; Hazekamp, A.; de Best, C.M.; Irth, H.; Tjaden, U.R.; van der Heijden, R.; van der Greef, J.; Verpoorte, R.

    2000-01-01

    An HPLC with on-line coupled UV/MS-biochemical detection method for acetylcholinesterase (AChE) inhibitors in natural sources has been developed. The potential of this method is shown by the isolation of a new AChE inhibitor from the alcoholic extract of Narcissus 'Sir Winston Churchill'. Combining

  15. Sir Sayyid Ahmed Kahn's History of the Bijnor Rebellion, Translated with Notes and Introduction. South Asia Series, Occasional Paper No. 17.

    Science.gov (United States)

    Michigan State Univ., East Lansing. Asian Studies Center.

    The Bijnor Rebellion of 1857 was a revolt of the Muslim minority in the Bijnor district of India against the British East India Company and Hindu loyalists. Sir Sayyid Ahmad Khan was an Indian Muslim serving the British Company. His account of the events of 1857 is the only one produced by an Indian who both participated in and analyzed the…

  16. Malingering as a Categorical or Dimensional Construct: The Latent Structure of Feigned Psychopathology as Measured by the SIRS and MMPI-2

    Science.gov (United States)

    Walters, Glenn D.; Rogers, Richard; Berry, David T. R.; Miller, Holly A.; Duncan, Scott A.; McCusker, Paul J.; Payne, Joshua W.; Granacher, Robert P., Jr.

    2008-01-01

    The 6 nonoverlapping primary scales of the Structured Interview of Reported Symptoms (SIRS) were subjected to taxometric analysis in a group of 1,211 criminal and civil examinees in order to investigate the latent structure of feigned psychopathology. Both taxometric procedures used in this study, mean above minus below a cut (MAMBAC) and maximum…

  17. Performance comparison and selection criteria: an assessment for choosing the best flight detector for the SIR-2 NIR-spectrometer on Chandrayaan-1

    Science.gov (United States)

    Sitek, P.; Vilenius, E.; Mall, U.

    2008-01-01

    We describe the performance evaluation of a sample of InGaAs detectors from which the best unit had to be selected for the flight model of the SIR-2 NIR-spectrometer to be flown on the Chandrayaan-1 mission in 2008.

  18. Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90α in Severe Sepsis and SIRS

    Directory of Open Access Journals (Sweden)

    K. Vardas

    2014-01-01

    Full Text Available Objective. To evaluate the early heat shock protein (HSP and hormonal stress response of intensive care unit (ICU patients with severe sepsis/septic shock (SS or systemic inflammatory response syndrome (SIRS compared to healthy subjects (H. Methods. Patients with early (first 48 hrs SS (n=29 or SIRS (n=29 admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72 and interleukins. Mean fluorescence intensity (MFI values for intracellular HSPs (iHSP72, iHSP90α were measured using 4-colour flow-cytometry. Results. Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H (P<0.003. ACTH and eHSP72 were significantly higher in SS and SIRS compared to H (P<0.005. SS monocytes expressed lower iHSP72 MFI levels compared to H (P=0.03. Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate (P<0.05. In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10. Conclusion. Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.

  19. K rozmnožení cti a chvály Boží a ku prospěchu vlasti. Mikuláš Walter z Waltersperku († 1578) a jeho studijní nadace

    Czech Academy of Sciences Publication Activity Database

    Holá, M.; Holý, Martin

    2013-01-01

    Roč. 28, č. 1 (2013), s. 5-27 ISSN 0231-7494 R&D Projects: GA ČR GPP405/12/P422 Institutional support: RVO:67985963 Keywords : educational foundations * Mikuláš Walter of Waltersperk * Prague University * Early Modern Period Subject RIV: AB - History

  20. PALAVRAS E HISTÓRIAS TRADUZIDAS ATRAVÉS DAS IMAGENS: UM PERCURSO FOTOGRÁFICO DE MÃOS DADAS COM DIDI-HUBERMAN E WALTER BENJAMIN

    Directory of Open Access Journals (Sweden)

    Monique Bione Silva

    2014-12-01

    Full Text Available Este artigo busca pensar a fotografia não apenas como imagem, mas entender o papel da mesma como arquivo histórico a partir da concepção de imagem crítica elaborada por Didi-Huberman. Cabe aqui compreender o conceito de Walter Benjamin de imagem dialética aplicado à produção fotográfica. Imagens e arquivos sob a ótica de Didi-Huberman, inseridas na contemporaneidade, abrem um leque para estudar a sua representatividade na nossa sociedade e de qual forma a mesma encara tais conceitos atualmente.

  1. La persistencia de los márgenes. Reflexiones epistemológicas en torno a la obra de Walter Mignolo

    Directory of Open Access Journals (Sweden)

    Ángel Octavio Álvarez Solís

    2010-01-01

    Full Text Available En este texto se analizan varias cuestiones suscitadas en torno a la obra de Walter Mignolo, principalmente el análisis de las condiciones que debe cumplir una teoría crítica decolonial. Para ello, en la primera parte se analizan los presupuestos epistemológicos que justifican la empresa teórica de Mignolo entendida como una epistemología de la postcolonialidad. En la segunda parte se desarrolla la forma en que nuestro autor utiliza el discurso histórico en su argumentación a fin de señalar por qué su interpretación puede entenderse como una hermenéutica de la deuda.

  2. Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS).

    Science.gov (United States)

    Florea, Daniela; Molina-López, Jorge; Hogstrand, Christer; Lengyel, Imre; de la Cruz, Antonio Pérez; Rodríguez-Elvira, Manuel; Planells, Elena

    2018-09-01

    Critically ill patients develop severe stress, inflammation and a clinical state that may raise the utilization and metabolic replacement of many nutrients and especially zinc, depleting their body reserves. This study was designed to assess the zinc status in critical care patients with systemic inflammatory response syndrome (SIRS), comparing them with a group of healthy people, and studying the association with expression of zinc transporters. This investigation was a prospective, multicentre, comparative, observational and analytic study. Twelve critically ill patients from different hospitals and 12 healthy subjects from Granada, Spain, all with informed consent were recruited. Data on daily nutritional assessment, ICU severity scores, inflammation, clinical and nutritional parameters, plasma and blood cell zinc concentrations, and levels of transcripts for zinc transporters in whole blood were taken at admission and at the seventh day of the ICU stay. Zinc levels on critical ill patient are diminish comparing with the healthy control (HS: 0.94 ± 0.19; CIPF: 0.67 ± 0.16 mg/dL). The 58% of critical ill patients showed zinc plasma deficiency at beginning of study while 50.0% of critical ill after 7 days of ICU stay. ZnT7, ZIP4 and ZIP9 were the zinc transporters with highest expression in whole blood. In general, all zinc transporters were significantly down-regulated (P < 0.05) in the critical ill population at admission in comparison with healthy subjects. Severity scores and inflammation were significantly associated (P < 0.05) with zinc plasma levels, and zinc transporters ZIP3, ZIP4, ZIP8, ZnT6, ZnT7. Expression of 11 out of 24 zinc transporters was analysed, and ZnT1, ZnT4, ZnT5 and ZIP4, which were downregulated by more than 3-fold in whole blood of patients. In summary, in our study an alteration of zinc status was related with the severity-of-illness scores and inflammation in critical ill patients since admission in ICU stay. SIRS

  3. Sjenički sir kao nematerijalno kulturno nasleđe: Antropološki pristup problemu

    Directory of Open Access Journals (Sweden)

    Ljiljana Gavrilović

    2017-01-01

    Full Text Available U radu se raspravlja o tradicionalnim tehnologijama kao nematerijalnom kulturnom nasleđu i iznosi se etnografija koja je rezultat rada na projektu pripreme dokumentacije za predlog upisa tehnologije proizvodnje sjeničkog sira u nacinalnu Listu nematerijalnih kulturnih dobara. U okviru toga razmotrena je tradicionalna tehnologija proizvodnje sjeničkog sira, kao i nastojanja lokalnih aktera da tu tehnologiju zaštite i sačuvaju. Zatim sledi analiza građe prikupljene u razgovorima s ispitanicima, pripadnicima lokalne zajednice – od samih proizvođača, pa do pojedinaca koji zauzimaju različite upravljačke pozicije. U ovom segmentu fokus je stavljen na svest i spoznaju koju sami lokalni akteri imaju o značaju proizvoda koji nastoje da zaštite i, kako oni sami kažu, „brendiraju“, ali pre svega na probleme sa kojima se suočavaju u tom procesu. Na kraju, analizirane su potencijalne mogućnosti realizacije projekta izrade aplikacije na osnovu koje bi sjenički sir bio upisan na Nacionalnu listu nematerijalnog kulturnog nasleđa. U tom segmentu, fokus je stavljen na delovanje menadžmenta lokalne zajednice, kao i mogućnosti profesionalnih antropologa da pomognu u realizaciji tog procesa.

  4. Return to the far side of planet Moore! rambling through observations, friendships and antics of sir Patrick Moore

    CERN Document Server

    Mobberley, Martin

    2015-01-01

    The result of an exhaustive study of Sir Patrick Moore’s observations of the Moon and planets for more than 60 years, this book is a fantastic companion to the extremely popular, “It Came From Outer Space Wearing an RAF Blazer!” written by the same author.  Moore recorded his telescopic observations in his logbooks, which are reproduced and described here in detail, along with his sketches and notes. In this light, the author discusses the factors that caused Moore to switch from lunar observing to planetary and variable star observing.  He has also included personal recollections and humorous anecdotes from Moore’s friends and acquaintances, as well as a look at his best loved books. Further chapters describe Moore’s foreign travels and correspondence with those back home. Lastly, the author has not neglected a few of Moore’s most memorable television and radio appearances, which are examined along with a close up of what it was like to visit Moore’s beloved home of Farthings in Selsey. Essen...

  5. Raman spectroscopic analyses of preserved historical specimens of human hair attributed to Robert Stephenson and Sir Isaac Newton.

    Science.gov (United States)

    Edwards, Howell G M; Hassan, Nik F N; Wilson, Andrew S

    2004-10-01

    The Raman spectra of two historical specimens of human hair attributed to the engineer Robert Stephenson and scientist Sir Isaac Newton, preserved in private collections are reported. Comparisons are made with the Raman spectra of modern hair specimens and with hair from archaeological excavations. The hair spectra collected with a laser excitation of 785 nm are of a better quality than those collected using 1064 nm. The historical hair specimens are remarkably well-defined spectroscopically in terms of the amide I vibrational mode and the [small nu](SS), ascribed to a predominantly gauche-gauche-gauche CSSC conformation. The contrast with degraded hair specimens recovered from archaeological excavations is striking. The presence of a weak feature near 2590 cm(-1) in the hair samples attributed to a [small nu](SH) vibration could be indicative of a reduction process operative on the CSSC cystine keratotic linkages and a possible origin of this is bacterial biodegradation identified histologically. This study demonstrates the molecular information available from non-destructive Raman spectroscopic analysis from single hair shafts or small bundles of fibres which complements information available from histological and destructive analytical techniques for rare biological specimens subjected to conservation or curation procedures in museums or private collections.

  6. Crystallization and preliminary X-ray diffraction studies of the putative haloalkane dehalogenase DppA from Plesiocystis pacifica SIR-I

    International Nuclear Information System (INIS)

    Bogdanović, Xenia; Hesseler, Martin; Palm, Gottfried J.; Bornscheuer, Uwe T.; Hinrichs, Winfried

    2010-01-01

    The crystallization and preliminary X-ray diffraction studies of DppA from P. pacifica SIR-I are reported. DppA from Plesiocystis pacifica SIR-I is a putative haloalkane dehalogenase (EC 3.8.1.5) and probably catalyzes the conversion of halogenated alkanes to the corresponding alcohols. The enzyme was expressed in Escherichia coli BL21 and purified to homogeneity by ammonium sulfate precipitation and reversed-phase and ion-exchange chromatography. The DppA protein was crystallized by the vapour-diffusion method and protein crystals suitable for data collection were obtained in the orthorhombic space group P2 1 2 1 2. The DppA crystal diffracted X-rays to 1.9 Å resolution using an in-house X-ray generator

  7. A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS

    DEFF Research Database (Denmark)

    Tavenier, Juliette; Haupt, Thomas Huneck; Andersen, Aino L

    2017-01-01

    inflammation in healthy elderly. We hypothesized that nutritional support and resistance training would accelerate the resolution of inflammation in hospitalized elderly patients with SIRS. Acutely admitted patients aged >65 years with SIRS were randomized to an intervention consisting of a high-protein diet...... (1.7 g/kg per day) during hospitalization, and daily protein supplement (18.8 g) and 3 weekly resistance training sessions for 12 weeks after discharge (Intervention, n=14), or to standard-care (Control, n=15). Plasma levels of the inflammatory biomarkers soluble urokinase plasminogen activator...... receptor (suPAR), interleukin-6, C-reactive protein (CRP), and albumin were measured at admission, discharge, and 4 and 13 weeks after discharge. The Intervention group had an earlier decrease in suPAR levels than the Control group: -15.4% vs. +14.5%, P=.007 during hospitalization, and -2.4% vs. -28.6%, P...

  8. Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine.

    Science.gov (United States)

    McILwain, R Britt; Timpa, Joseph G; Kurundkar, Ashish R; Holt, David W; Kelly, David R; Hartman, Yolanda E; Neel, Mary Lauren; Karnatak, Rajendra K; Schelonka, Robert L; Anantharamaiah, G M; Killingsworth, Cheryl R; Maheshwari, Akhil

    2010-01-01

    Extracorporeal membrane oxygenation (ECMO) is a life-saving support system used in neonates and young children with severe cardiorespiratory failure. Although ECMO has reduced mortality in these critically ill patients, almost all patients treated with ECMO develop a systemic inflammatory response syndrome (SIRS) characterized by a 'cytokine storm', leukocyte activation, and multisystem organ dysfunction. We used a neonatal porcine model of ECMO to investigate whether rising plasma concentrations of inflammatory cytokines during ECMO reflect de novo synthesis of these mediators in inflamed tissues, and therefore, can be used to assess the severity of ECMO-related SIRS. Previously healthy piglets (3-week-old) were subjected to venoarterial ECMO for up to 8 h. SIRS was assessed by histopathological analysis, measurement of neutrophil activation (flow cytometry), plasma cytokine concentrations (enzyme immunoassays), and tissue expression of inflammatory genes (PCR/western blots). Mast cell degranulation was investigated by measurement of plasma tryptase activity. Porcine neonatal ECMO was associated with systemic inflammatory changes similar to those seen in human neonates. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) concentrations rose rapidly during the first 2 h of ECMO, faster than the tissue expression of these cytokines. ECMO was associated with increased plasma mast cell tryptase activity, indicating that increased plasma concentrations of inflammatory cytokines during ECMO may result from mast cell degranulation and associated release of preformed cytokines stored in mast cells. TNF-alpha and IL-8 concentrations rose faster in plasma than in the peripheral tissues during ECMO, indicating that rising plasma levels of these cytokines immediately after the initiation of ECMO may not reflect increasing tissue synthesis of these cytokines. Mobilization of preformed cellular stores of inflammatory cytokines such as in mucosal mast cells may have

  9. The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

    Science.gov (United States)

    The establishment of the epigenetic mark H4K20me1 (monomethylation of H4K20) by PR-Set7 during G2/M directly impacts S-phase progression and genome stability. However, the mechanisms involved in the regulation of this event are not well understood. Here we show that SirT2 regulates H4K20me1 depositi...

  10. Genes ycfR, sirA and yigG contribute to the surface attachment of Salmonella enterica Typhimurium and Saintpaul to fresh produce.

    Directory of Open Access Journals (Sweden)

    Joelle K Salazar

    Full Text Available Salmonella enterica is a frequent contaminant of minimally-processed fresh produce linked to major foodborne disease outbreaks. The molecular mechanisms underlying the association of this enteric pathogen with fresh produce remain largely unexplored. In our recent study, we showed that the expression of a putative stress regulatory gene, ycfR, was significantly induced in S. enterica upon exposure to chlorine treatment, a common industrial practice for washing and decontaminating fresh produce during minimal processing. Two additional genes, sirA involved in S. enterica biofilm formation and yigG of unknown function, were also found to be differentially regulated under chlorine stress. To further characterize the roles of ycfR, sirA, and yigG in S. enterica attachment and survival on fresh produce, we constructed in-frame deletions of all three genes in two different S. enterica serovars, Typhimurium and Saintpaul, which have been implicated in previous disease outbreaks linked to fresh produce. Bacterial attachment to glass and polystyrene microtiter plates, cell aggregation and hydrophobicity, chlorine resistance, and surface attachment to intact spinach leaf and grape tomato were compared among wild-type strains, single-gene deletion mutants, and their respective complementation mutants. The results showed that deletions of ycfR, sirA, and yigG reduced bacterial attachment to glass and polystyrene as well as fresh produce surface with or without chlorine treatment in both Typhimurium and Saintpaul. Deletion of ycfR in Typhimurium significantly reduced bacterial chlorine resistance and the attachment to the plant surfaces after chlorinated water washes. Deletions of ycfR in Typhimurium and yigG in Saintpaul resulted in significant increase in cell aggregation. Our findings suggest that ycfR, sirA, and yigG collectively contribute to S. enterica surface attachment and survival during post-harvest minimal processing of fresh produce.

  11. Shuttle Experimental Radar for Geological Exploration (SERGE) project: Field work relating to the Shuttle Experimental Radar A (SIR-A) in Brazil (phase 2)

    Science.gov (United States)

    Balieiro, M. G.; Martini, P. R.; Dossantos, J. R.; Demattos, J. T.

    1984-01-01

    The ground observations undertaken over the northern position of Minas Gerais State, and part of Distrito Federal from 7 to 12 December 1982, along the Space Shuttle 2 flying orbit 22 of November 1981 are described. Field data related mostly with lithology, geological structures and forest cover, and specific geomorphological and pedological aspects were collected. Ground data are applied to evaluate the SIR-A Experiment, developed in the Space Shuttle-2 mission for natural resources mapping and prospecting.

  12. Increased extracellular heat shock protein 90α in severe sepsis and SIRS associated with multiple organ failure and related to acute inflammatory-metabolic stress response in children.

    Science.gov (United States)

    Fitrolaki, Michaela-Diana; Dimitriou, Helen; Venihaki, Maria; Katrinaki, Marianna; Ilia, Stavroula; Briassoulis, George

    2016-08-01

    Mammalian heat-shock-protein (HSP) 90α rapidly responses to environmental insults. We examined the hypothesis that not only serum HSP72 but also HSP90α is increased in the systemic inflammatory response syndrome (SIRS), severe-sepsis (SS), and/or sepsis (S) compared to healthy children (H); we assessed HSP90α relation to (a) multiple organ system failure (MOSF) and (b) inflammatory-metabolic response and severity of illness.A total of 65 children with S, SS, or SIRS and 25 H were included. ELISA was used to evaluate extracellular HSP90α and HSP72, chemiluminescence interleukins (ILs), flow-cytometry neutrophil-CD64 (nCD64)-expression.HSP90α, along with HSP72, were dramatically increased among MOSF patients. Patients in septic groups and SIRS had elevated HSP90α compared to H (P stress, fever, outcome endpoints, and predicted mortality and inversely related to the low-LDL/low-HDL stress metabolic pattern.

  13. UK Institute of Physics (IOP) President Sir Gareth Roberts (right) at CERN on 9 July with (right to left) IOP council vice-president and distinguished physicist Peter Kalmus, CERN engineer Tim Watson and IOP director of science Peter Cooper

    CERN Multimedia

    Patrice Loiez

    1999-01-01

    UK Institute of Physics (IOP) President Sir Gareth Roberts (right) at CERN on 9 July with (right to left) IOP council vice-president and distinguished physicist Peter Kalmus, CERN engineer Tim Watson and IOP director of science Peter Cooper

  14. Professor Sir Mark Walport Government Chief Scientific Adviser Head of Government Science and Engineering Profession Chief Executive Designate of UK Research and Innovation United Kingdom of Great Britain and Northern Ireland

    CERN Multimedia

    Bennett, Sophia Elizabeth

    2017-01-01

    Professor Sir Mark Walport Government Chief Scientific Adviser Head of Government Science and Engineering Profession Chief Executive Designate of UK Research and Innovation United Kingdom of Great Britain and Northern Ireland

  15. Testing different brain metastasis grading systems in stereotactic radiosurgery: Radiation Therapy Oncology Group's RPA, SIR, BSBM, GPA, and modified RPA.

    Science.gov (United States)

    Serizawa, Toru; Higuchi, Yoshinori; Nagano, Osamu; Hirai, Tatsuo; Ono, Junichi; Saeki, Naokatsu; Miyakawa, Akifumi

    2012-12-01

    The authors conducted validity testing of the 5 major reported indices for radiosurgically treated brain metastases- the original Radiation Therapy Oncology Group's Recursive Partitioning Analysis (RPA), the Score Index for Radiosurgery in Brain Metastases (SIR), the Basic Score for Brain Metastases (BSBM), the Graded Prognostic Assessment (GPA), and the subclassification of RPA Class II proposed by Yamamoto-in nearly 2500 cases treated with Gamma Knife surgery (GKS), focusing on the preservation of neurological function as well as the traditional endpoint of overall survival. The authors analyzed data from 2445 cases treated with GKS by the first author (T.S.), the primary surgeon. The patient group consisted of 1716 patients treated between January 1998 and March 2008 (the Chiba series) and 729 patients treated between April 2008 and December 2011 (the Tokyo series). The interval from the date of GKS until the date of the patient's death (overall survival) and impaired activities of daily living (qualitative survival) were calculated using the Kaplan-Meier method, while the absolute risk for two adjacent classes of each grading system and both hazard ratios and 95% confidence intervals were estimated using the Cox proportional hazards model. For overall survival, there were highly statistically significant differences between each two adjacent patient groups characterized by class or score (all p values RPA appeared to be better than the original RPA and GPA. The modified RPA subclassification, proposed by Yamamoto, is well balanced in scoring simplicity with respect to case number distribution and statistical results for overall survival. However, a new or revised grading system is necessary for predicting qualitative survival and for selecting the optimal treatment for patients with brain metastasis treated by GKS.

  16. Survey of methods of facial palsy documentation in use by members of the Sir Charles Bell Society.

    Science.gov (United States)

    Fattah, Adel Y; Gavilan, Javier; Hadlock, Tessa A; Marcus, Jeffrey R; Marres, Henri; Nduka, Charles; Slattery, William H; Snyder-Warwick, Alison K

    2014-10-01

    Facial palsy manifests a broad array of deficits affecting function, form, and psychological well-being. Assessment scales were introduced to standardize and document the features of facial palsy and to facilitate the exchange of information and comparison of outcomes. The aim of this study was to determine which assessment methodologies are currently employed by those involved in the care of patients with facial palsy as a first step toward the development of consensus on the appropriate assessments for this patient population. Online questionnaire. The Sir Charles Bell Society, a group of professionals dedicated to the care of patients with facial palsy, were surveyed to determine the scales used to document facial nerve function, patient reported outcome measures (PROM), and photographic documentation. Fifty-five percent of the membership responded (n = 83). Grading scales were used by 95%, most commonly the House-Brackmann and Sunnybrook scales. PROMs were used by 58%, typically the Facial Clinimetric Evaluation scale or Facial Disability Index. All used photographic recordings, but variability existed among the facial expressions used. Videography was performed by 82%, and mostly involved the same views as still photography; it was also used to document spontaneous movement and speech. Three-dimensional imaging was employed by 18% of respondents. There exists significant heterogeneity in assessments among clinicians, which impedes straightforward comparisons of outcomes following recovery and intervention. Widespread adoption of structured assessments, including scales, PROMs, photography, and videography, will facilitate communication and comparison among those who study the effects of interventions on this population. © 2014 The American Laryngological, Rhinological and Otological Society, Inc.

  17. The dark knight : Sir Thomas Tait and the rise and fall of New Brunswick's famous coalfields

    Energy Technology Data Exchange (ETDEWEB)

    Woodford, G.

    2010-03-15

    Industrial coal mining in New Brunswick began in the early 1900s. In 1913, a former Canadian Pacific Railway (CPR) manager, Sir Thomas Tait, learned of underexploited coalfields around Grand Lake and negotiated the best coal assets from locals. He used his CPR connections to secure a large government grant to finish an important 50-kilometre railway link between Minto and Fredericton. He kept the coal assets for himself and formed the Minto Coal Company and landed 2 prime contracts to supply coal to a nearby cotton mill and to CPR. This article highlighted Tait's disreputable approach to labour relations. Despite lucrative contracts to Minto Coal during World War 1, Tait did not share the profits with his miners. This coal mining period in New Brunswick was characterized by union busting, evictions from dire company housing, arbitrary pay cuts, strikes and increasingly unsafe conditions in the mines. Two royal commissions were called to look into matters, but the province had no legislation to enforce their many recommendations. However, the government finally passed legislation when in 1932, 5 people died trying to rescue boys who were poisoned while playing in an abandoned mine shaft. That same year, 14 miners were disabled and 2 men killed in accidents at Minto Coal. Legislation forced mines to reduce work hours and improve safety. Women and children were barred from mining. When Tait refused to reduce work hours the miners went on strike again. After a critical situation in 1937 when 1000 miner and 11 colliers walked out, things gradually improved for both the miners and mine owners. New technology in the 1940s led to greater production, safety and profits. In 1944, Minto Coal donated land and money to build the town's first hospital. Credit for this philanthropy did not go to Thomas Tait, who died in 1940.

  18. Synchrony of sylvatic dengue isolations: a multi-host, multi-vector SIR model of dengue virus transmission in Senegal.

    Directory of Open Access Journals (Sweden)

    Benjamin M Althouse

    Full Text Available Isolations of sylvatic dengue-2 virus from mosquitoes, humans and non-human primates in Senegal show synchronized multi-annual dynamics over the past 50 years. Host demography has been shown to directly affect the period between epidemics in other pathogen systems, therefore, one might expect unsynchronized multi-annual cycles occurring in hosts with dramatically different birth rates and life spans. However, in Senegal, we observe a single synchronized eight-year cycle across all vector species, suggesting synchronized dynamics in all vertebrate hosts. In the current study, we aim to explore two specific hypotheses: 1 primates with different demographics will experience outbreaks of dengue at different periodicities when observed as isolated systems, and that coupling of these subsystems through mosquito biting will act to synchronize incidence; and 2 the eight-year periodicity of isolations observed across multiple primate species is the result of long-term cycling in population immunity in the host populations. To test these hypotheses, we develop a multi-host, multi-vector Susceptible, Infected, Removed (SIR model to explore the effects of coupling multiple host-vector systems of dengue virus transmission through cross-species biting rates. We find that under small amounts of coupling, incidence in the host species synchronize. Long-period multi-annual dynamics are observed only when prevalence in troughs reaches vanishingly small levels (< 10(-10, suggesting that these dynamics are inconsistent with sustained transmission in this setting, but are consistent with local dengue virus extinctions followed by reintroductions. Inclusion of a constant introduction of infectious individuals into the system causes the multi-annual periods to shrink, while the effects of coupling remain the same. Inclusion of a stochastic rate of introduction allows for multi-annual periods at a cost of reduced synchrony. Thus, we conclude that the eight-year period

  19. Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent

    Science.gov (United States)

    Nakane, Takanori; Hanashima, Shinya; Suzuki, Mamoru; Saiki, Haruka; Hayashi, Taichi; Kakinouchi, Keisuke; Sugiyama, Shigeru; Kawatake, Satoshi; Matsuoka, Shigeru; Matsumori, Nobuaki; Nango, Eriko; Kobayashi, Jun; Shimamura, Tatsuro; Kimura, Kanako; Mori, Chihiro; Kunishima, Naoki; Sugahara, Michihiro; Takakyu, Yoko; Inoue, Shigeyuki; Masuda, Tetsuya; Hosaka, Toshiaki; Tono, Kensuke; Joti, Yasumasa; Kameshima, Takashi; Hatsui, Takaki; Inoue, Tsuyoshi; Nureki, Osamu; Iwata, So; Murata, Michio; Mizohata, Eiichi

    2016-01-01

    The 3D structure determination of biological macromolecules by X-ray crystallography suffers from a phase problem: to perform Fourier transformation to calculate real space density maps, both intensities and phases of structure factors are necessary; however, measured diffraction patterns give only intensities. Although serial femtosecond crystallography (SFX) using X-ray free electron lasers (XFELs) has been steadily developed since 2009, experimental phasing still remains challenging. Here, using 7.0-keV (1.771 Å) X-ray pulses from the SPring-8 Angstrom Compact Free Electron Laser (SACLA), iodine single-wavelength anomalous diffraction (SAD), single isomorphous replacement (SIR), and single isomorphous replacement with anomalous scattering (SIRAS) phasing were performed in an SFX regime for a model membrane protein bacteriorhodopsin (bR). The crystals grown in bicelles were derivatized with an iodine-labeled detergent heavy-atom additive 13a (HAD13a), which contains the magic triangle, I3C head group with three iodine atoms. The alkyl tail was essential for binding of the detergent to the surface of bR. Strong anomalous and isomorphous difference signals from HAD13a enabled successful phasing using reflections up to 2.1-Å resolution from only 3,000 and 4,000 indexed images from native and derivative crystals, respectively. When more images were merged, structure solution was possible with data truncated at 3.3-Å resolution, which is the lowest resolution among the reported cases of SFX phasing. Moreover, preliminary SFX experiment showed that HAD13a successfully derivatized the G protein-coupled A2a adenosine receptor crystallized in lipidic cubic phases. These results pave the way for de novo structure determination of membrane proteins, which often diffract poorly, even with the brightest XFEL beams. PMID:27799539

  20. Hacia una crítica del historicismo: Gustave Flaubert y las tesis Sobre el concepto de Historia de Walter Benjamin

    Directory of Open Access Journals (Sweden)

    Jorge Luis Caputo

    2018-04-01

    Full Text Available In the seventh thesis of his essay On the concept of History, Walter Benjamin presents Gustave Flaubert as a representative figure of the empathic sensibility that underlies the historicist current of historiography. The first aim of this article is to analyze this mention and to confront it with other texts where Benjamin reflects on Flaubert: in this regard, it can be said that the concise judgment of the seventh thesis, in which Flaubert becomes the symbol of the inactive melancholy of historicism, can be challenged. Secondly, the article intends to prove that Flaubert’s literature (specially through the genre of historic novel as it is exemplified by Salammbô achieves two of the tasks that Benjamin assigns to the dialectical-materialistic historian: on one side, to be capable of hearing the grieving complaints of the defeated dead; on the other, to restitute potentiality in the past. En la séptima tesis del ensayo Sobre el concepto de Historia, Walter Benjamin presenta a Gustave Flaubert como la encarnación de la sensibilidad empática y pesimista que se encuentra en la base de la concepción historicista de la historia. El propósito de este trabajo es, en primer lugar, analizar esa mención contrastándola con el resto de los materiales benjaminianos en los que se hace mención de Flaubert: se verá que, así considerada, la fórmula apodíctica de la tesis (que erige al novelista como el emblema de la melancolía inactiva característica del historicismo admite ser matizada. En segundo lugar, se demostrará que la literatura de Flaubert (particularmente en su variante histórica encarnada por Salammbô cumple con dos de las tareas fundamentales que Benjamin asigna al historiador dialéctico-materialista: por un lado, disponerse a la escucha de los vencidos de la historia; por el otro, restituir la potencia del pasado.

  1. Von der Stadtsoziologie des Bürgertums zur Stadtsoziologie der industriellen Moderne? Kommentar zu Hartmut Häußermann & Walter Siebels „Thesen zur Soziologie der Stadt“

    Directory of Open Access Journals (Sweden)

    Johanna Hoerning

    2013-07-01

    Full Text Available Der hier wieder veröffentlichte Artikel von Hartmut Häußermann und Walter Siebel aus dem Jahr 1978 ist beides, hoch aktuell – und ein Zeitzeuge. In jedem Fall aber ist er ein lehrreiches Traktat über die Frage nach dem Selbstverständnis einer gesellschaftstheoretischen und kritischen Soziologie, sowie über die methodologische Eruierung dessen, was im Rahmen einer so verstandenen (politischen Soziologie Stadtforschung sein kann [...

  2. As estruturas da reificação em curso: Walter Benjamin e Guy Debord, leitores de História e Consciência de Classe

    Directory of Open Access Journals (Sweden)

    Deni Rubbo

    2010-06-01

    Full Text Available Partindo dos pressupostos da centralidade do fetichismo da mercadoria, lançados em História e Consciência de Classe, Lukács aqueceu alguns estudos posteriores, no âmbito do marxismo, tanto nos desdobramentos da teoria como na propulsão de reescrever a história. Em um primeiro momento, o foco será a relação desigual entre Marx e Lukács, no que concerne ao fenômeno da reificação. Depois, serão destacados os estudos de Walter Benjamin, em sua análise sobre a metrópole parisiense no século XIX, e Guy Debord, em uma explanação sobre um novo grau do fenômeno reificado, implicando uma imagem-espetáculo da vida social humana. Para ambos, as tensões temporais do mundo capitalista industrial e moderno se caracterizam em um “tempo prisioneiro” e para o qual tal rompimento incidiria sobre a negatividade do mundo do capital, atualizando, assim, em outros níveis, os postulados sobre fenômeno da reificação.

  3. Velhice, experiência e resistência: a ressignificação da memória nas obras de Ingmar Bergman e Walter Benjamin

    Directory of Open Access Journals (Sweden)

    Rafael de Souza Dias

    2014-10-01

    Full Text Available Este texto apresenta uma breve reflexão sobre o ato de rememorar como um exercício motivador e gerador de novas perspectivas diante da vida na velhice. Para sua elaboração, utilizou-se como referência o filme “Morangos Silvestres”, de Ingmar Bergman, e o texto “A Infância em Berlim por volta de 1900”, de Walter Benjamin. Na obra literária, nos deparamos com a autobiografia de um filósofo que escreve diante da perseguição nazista e que vê a sua cidade sucumbir aos poderes autoritários, utilizando-se, assim, da memória como uma forma de lutar contra a opressão. No cinema, acompanhamos um personagem idoso e supostamente fictício que ao perceber a proximidade da morte, mergulha em uma viagem através de sua juventude, onde revê suas escolhas e avalia sua vida. Em ambas as obras, os personagens fazem das suas lembranças uma forma de ressignificar o presente.

  4. Experiência e tradição em Walter Benjamin: ressonâncias para a educação

    Directory of Open Access Journals (Sweden)

    Sérgio Luiz Alves da Rocha

    2016-02-01

    Full Text Available O proceso educativo faz com que diferentes gerações tenham que relacionar-se. Diante das modifcações dos últimos anos, alguns professores, adotam ora uma perspectiva saudosista, ora um discurso que valoriza de modo extremo os jovens e o novo. A ênfase, seja na experiência dos mais velhos, com a consequente desvalorização dos mais jovens, ou da experiência dos mais jovens, renegando-se a experiência dos mais velhos, nos impede de estabelecer pontes entre as gerações. Utilizo alguns textos de Walter Benjamin para refetir sobre o significado da experiência e da tradição. As ideias de Benjamin me permitem pensar sobre a relação entre as gerações no interior da escola a partir de uma postura ética que reconheça nosso papel como representantes de uma determinada tradição sem deixar de estarmos abertos às experiências dos jovens.

  5. [Narratives in the study of mental health care practices: contributions of the perspectives of Paul Ricoeur, Walter Benjamin and of medical anthropology].

    Science.gov (United States)

    Onocko-Campos, Rosana Teresa; Palombini, Analice de Lima; Leal, Erotildes; de Serpa, Octavio Domont; Baccari, Ivana Oliveira Preto; Ferrer, Ana Luiza; Diaz, Alberto Giovanello; Xavier, Maria Angélica Zamora

    2013-10-01

    Narratives are ever more frequent in qualitative studies seeking to interpret experiences and the different viewpoints of individuals in a given context. Starting from this concept, the tradition that addresses narrative is reexamined, including the philosophy of Paul Ricoeur, the historical perspective of Walter Benjamin and the field of medical anthropology grounded in phenomenology. In Ricoeur, with hermeneutics as a variation derived from phenomenology, narrative is linked to temporality. In Benjamin, narrative comprised of bits and pieces, always inconclusive, emerges in spite of the official stories. If Ricoeur retrieves tradition from Gadamer as a fundamental component for the construction of the world of a text that makes imitation of life possible, Benjamin, faced with the collapse of tradition, suggests the invention of narrative forms outside the traditional canons, making it possible to hark to the past in order to change the present. Assumptions of medical anthropology are also presented, as they consider narrative a dimension of life and not its abstraction, namely an embodied and situated narrative. Lastly, three distinct research projects in mental health that use narrative linked to the theoretical concepts cited with their differences and similarities are presented.

  6. Alte Thesen neu gelesen: Perspektiven kritischer Stadtforschung. Kommentar zu Hartmut Häußermann & Walter Siebels „Thesen zur Soziologie der Stadt“

    Directory of Open Access Journals (Sweden)

    Carsten Keller

    2013-07-01

    Full Text Available [Dieser Artikel ist Teil einer Debatte] Der Text „Thesen zur Soziologie der Stadt“ scheint mir besonders in den abschließend formulierten Perspektiven, die Hartmut Häußermann und Walter Siebel unter der Überschrift „Aufgaben einer kritischen Soziologie der Stadt“ formulieren, nach wie vor lesenswert und aktuell zu sein. Drei Perspektiven werden hier aufgezeigt: erstens eine Wissenschafts- und Ideologiekritik, zweitens eine empirisch orientierte Zustandsbeschreibung städtischer Strukturen und von Stadtentwicklung sowie drittens eine Analyse der staatlichen Stadtpolitik. Diese drei abschließenden Perspektiven möchte ich im Folgenden kommentieren. Es wird mithin keine immanente Auseinandersetzung mit dem gesamten Text und weiteren Arbeiten der beiden Autoren angestrebt. Es hätte mich zwar durchaus gereizt, die Entwicklung der Arbeiten von Häußermann und Siebel vor dem Hintergrund dieses frühen, emphatisch formulierten Textes zu reflektieren. Vielleicht auch wegen der persönlichen Bekanntschaft mit Häußermann, den ich als Projekt- und Dissertationsbetreuer an der Humboldt-Universität kennenlernte, erschien mir eine solche Zugangsweise zu den „Thesen“ durchaus naheliegend. [...

  7. A perspective on 10-years HTS experience at the Walter and Eliza Hall Institute of Medical Research - eighteen million assays and counting.

    Science.gov (United States)

    Lackovic, Kurt; Lessene, Guillaume; Falk, Hendrik; Leuchowius, Karl-Johan; Baell, Jonathan; Street, Ian

    2014-03-01

    The Walter and Eliza Hall Institute of Medical Research (WEHI) is Australia's longest serving medical research institute. WEHI's High Throughput Screening (HTS) Facility was established in 2003 with $5 million of infrastructure funds invested by WEHI, and the Victorian State Government's Strategic Technology Initiative through Bio21 Australia Ltd. The Facility was Australia's first truly academic HTS facility and was one of only a handful operating in publicly funded institutions worldwide at that time. The objectives were to provide access to enabling HTS technologies, such as assay design, liquid handling automation, compound libraries and expertise to promote translation of basic research in a national setting that has a relatively young biotech sector and does not have a big Pharma research presence. Ten years on and the WEHI HTS Facility has participated in over 92 collaborative projects, generated over 18 million data points, and most importantly, projects that began in the Facility have been commercialized successfully (due to strong ties with Business Development and emphasis on intellectual property management) and now have molecules progressing in clinical trials.

  8. Sir William Rowan Hamilton

    Indian Academy of Sciences (India)

    IAS Admin

    In this picture, wave fronts are defined as surfaces of constant S(x), while .... Recall here that physical quantities are represented in ... his memory imperishable? Hamilton ... self in the words Ptolemy used of Hipparchus: a lover of labour and a ...

  9. Koeberg prawns, sir..

    International Nuclear Information System (INIS)

    Champion, Harold

    1978-01-01

    Aquaculture as a profitable off-shoot of nuclear and conventional power production is being investigated scientifically by the Fisheries Development Corporation at its prawns research centre, sited on South Africa's east coast

  10. Sir Prafulla Chandra Ray

    Indian Academy of Sciences (India)

    New Chemical Laboratory, Alercurous Nitrite and History of Hindu Chemistry ... I dreamt a dream that, God willing, a time would come when she too would contribute her .... of his encyclopaedic work on Syriac, Arabic, and middle-age alchemy.

  11. Sir William Rowan Hamilton

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 21; Issue 6 ... and in particular of mechanics, over thecenturies since Galileo and Newton, we ... and the remarkableways in which his work paved the way to theconstruction ...

  12. To Sir, with Love

    Science.gov (United States)

    Hunt, Jonathan

    2011-01-01

    This article presents an interview with Terry Pratchett, one of the world's most beloved storytellers. And with sales of more than 65 million books in 37 languages, he's indisputably one of the most successful. The English novelist's many honors include a knighthood from Queen Elizabeth, more than a half dozen honorary doctorates, and the 2008…

  13. Sir Hermann Bondi KCB

    Science.gov (United States)

    Roxburgh, Ian W.

    2007-12-01

    Hermann Bondi was an Applied Mathematician of distinction who will be remembered by fellow scientists for his outstanding contributions to astronomy, cosmology and General Relativity, and particularly for his pioneering contributions to our understanding of gravitational waves, his foundational work on accretion, and as co-creator with Tommy Gold and Fred Hoyle of the steady state theory of cosmology. But Hermann had an equally important second career in scientific administration: advising the UK Government on the Thames Barrier, as Director General of the European Space Research Organisation (ESRO; now the European Space Agency (ESA)), as Chief Scientific Advisor to the UK Government on Defence and then on Energy, as Chairman of the Natural Environmental Research Council (NERC), and finally as Master of Churchill College, Cambridge. He was knighted in 1973. He continued his research on gravitational radiation throughout his administrative career and published his 16th paper in the series on gravitational waves in 2004. Hermann will be remembered not only for his contributions to science and administration, but for his outstanding communication skills and as a charismatic, warm, and stimulating person.

  14. Sir Gilbert Thomas Walker

    Indian Academy of Sciences (India)

    He was educated at St Paul's School and later at the. Trinity College ... Walker spent the next 21 years doing research on monsoon ... J Bjerknes in 1969, 11 years after Walker's death. ... water-colours of landscapes at the Shimla Art Exhibition.

  15. Sir Gilbert Thomas Walker

    Indian Academy of Sciences (India)

    playa fundamental role in the variability of the earth's climate. Walker noted a tendency of ... Walker was however not able to ascertain the physical mechanism governing these oscillations. In the first two ... In 1927, he made the follow- ing prophetic statement: "There is, to-day, always a risk that specialists in two subjects,.

  16. [Sir Humphry Davy, the discoverer of anesthetic action of nitrous oxide--Davy and poets of British Romanticism and inhalation of laughing gas by his friends].

    Science.gov (United States)

    Fujita, T

    1998-01-01

    In "Dove Cottage", the old house of the poet laureate William Wordsworth (1770-1850) in Grasmere, England, there is a portrait of Sir Humphry Davy (1778-1829). In 1804, Wordsworth invited his young friend to his home. Davy's works in the field of chemistry are well known. Interestingly enough, once he wished he could be a poet. His future seemed to be prosperous and delightful. He was highly evaluated by Robert Southey, poet laureate. But he has chosen the way of chemist. The author found some facts from literatures and received some information by courtesy of the Wordsworth Trust, Centre for British Romanticism. Davy's life and his works were introduced chronologically.

  17. Il mito di Ulisse nel romanzo del secondo Novecento: il tragico e l’antitragico in Stefano D’Arrigo e Walter Jens

    Directory of Open Access Journals (Sweden)

    Nora Moll

    2017-11-01

    Full Text Available In Twentieth Century’s Literature, the various declinations and rewritings of the Odysseus’ theme were conducted both in the tragic and the anti-tragic mode: the latter involving often, but not necessarily, the use of narrative strategies of parody. Referring to Hans Blumenberg (1979, we can speak of a constant “work on myth” that goes hand in hand with the development of postmodern poetics and elaboration of history, characterized by different narrative styles and strategies depending on the literary and cultural context in which they are inserted. Starting from one of the main theories about literary rewriting, as well as about mythopoetic and mythocritical discourse in twentieth century, this article aims to examine in a comparative perspective two novels, conceived almost at the same time in the Fifties, even if published separated by a distance of years. This is the "Mediterranean" novel Hocynus Orca (1975, by the Sicilian Stefano D'Arrigo, and Das Testament des Odysseus (1957, by the German writer Walter Jens, who is also known for his theoretical work on Greek mythology and tragedy. In these novels both authors choose the odyssean hypotext for liaising with the difficult legacy of World War II, but also to express its positioning in the contemporary world. The need to "complete" (Blumenberg the myth of Ulysses thus produces in D'Arrigo a reinterpretation of the novel in the epic and tragic way, while Jens escapes to the anti-tragic modus offering to its anti-hero a secondary way out from his own myth.

  18. An RNA Phage Lab: MS2 in Walter Fiers' laboratory of molecular biology in Ghent, from genetic code to gene and genome, 1963-1976.

    Science.gov (United States)

    Pierrel, Jérôme

    2012-01-01

    The importance of viruses as model organisms is well-established in molecular biology and Max Delbrück's phage group set standards in the DNA phage field. In this paper, I argue that RNA phages, discovered in the 1960s, were also instrumental in the making of molecular biology. As part of experimental systems, RNA phages stood for messenger RNA (mRNA), genes and genome. RNA was thought to mediate information transfers between DNA and proteins. Furthermore, RNA was more manageable at the bench than DNA due to the availability of specific RNases, enzymes used as chemical tools to analyse RNA. Finally, RNA phages provided scientists with a pure source of mRNA to investigate the genetic code, genes and even a genome sequence. This paper focuses on Walter Fiers' laboratory at Ghent University (Belgium) and their work on the RNA phage MS2. When setting up his Laboratory of Molecular Biology, Fiers planned a comprehensive study of the virus with a strong emphasis on the issue of structure. In his lab, RNA sequencing, now a little-known technique, evolved gradually from a means to solve the genetic code, to a tool for completing the first genome sequence. Thus, I follow the research pathway of Fiers and his 'RNA phage lab' with their evolving experimental system from 1960 to the late 1970s. This study illuminates two decisive shifts in post-war biology: the emergence of molecular biology as a discipline in the 1960s in Europe and of genomics in the 1990s.

  19. Do Génio ao jogo. O papel da Técnica na Transformação dos Valores Estéticos em Walter Benjamin

    Directory of Open Access Journals (Sweden)

    Nélio Rodrigues Conceição

    Full Text Available Resumo: Analisando o papel desempenhado pela questão da técnica no pensamento de Walter Benjamin, o artigo debruça-se sobre a transformação dos valores estéticos, na modernidade. As técnicas de reprodução/registo inventadas nos séculos XIX e XX, como a fotografia e o cinema, obrigaram a uma revisão das articulações entre arte, técnica e história, articulações que Benjamin desenvolveu em diversos sentidos. Contudo, não encontramos, nos seus textos, uma filosofia da técnica de princípios claramente estabelecidos. Portanto, o presente artigo visa estabelecer uma constelação de temas, os quais, brotando dos seus textos, nos permitem clarificar como a técnica influencia a transformação e a criação de valores estéticos, sendo estes entendidos como eixos em torno dos quais se dão a produção e a crítica dos fenómenos estéticos. A fotografia, constituindo um momento de viragem incisivamente estudado pelo autor, é o fio condutor das diferentes leituras. Historicidade da percepção; dimensão política da arte; sua relação com a memória; elemento de jogo: são estes os quatro eixos em torno dos quais se procura clarificar e, sempre que possível, prolongar a proposta benjaminiana.

  20. Activatable Optical Imaging with a Silica-Rhodamine Based Near Infrared (SiR700) Fluorophore: A comparison with cyanine based dyes

    Science.gov (United States)

    McCann, Thomas E.; Kosaka, Nobuyuki; Koide, Yuichiro; Mitsunaga, Makoto; Choyke, Peter L.; Nagano, Tetsuo; Urano, Yasuteru; Kobayashi, Hisataka

    2011-01-01

    Optical imaging is emerging as an important tool to visualize tumors. However, there are many potential choices among the available fluorophores. Optical imaging probes that emit in the visible range can image superficial tumors with high quantum yields, however, if deeper imaging is needed then near infrared (NIR) fluorophores are necessary. Most commercially available NIR fluorophores are cyanine based and are prone to non-specific binding and relatively limited photostability. Silica-containing rhodamine (SiR) fluorophores represent a new class of NIR fluorophores, which permit photoactivation via H-dimer formation as well as demonstrate improved photostability. This permits higher tumor-to-background ratios (TBRs) to be achieved over longer periods of time. Here, we compared an avidin conjugated with SiR700 (Av-SiR700) to similar compounds based on cyanine dyes (Av-Cy5.5 and Av-Alexa Fluor 680) in a mouse tumor model of ovarian cancer metastasis. We found that the Av-SiR700 probe demonstrated superior quenching enabling activation after binding-internalization to the target cell. As a result, Av-SiR700 had higher TBRs compared to Av-Cy5.5, and better biostability compared to Av-Alexa Fluor 680. PMID:22034863

  1. Analysis of subsequent publication and impact of abstracts presented at the Sir Peter Freyer Surgical Symposium: Focus on the Plenary Session.

    Science.gov (United States)

    O' Connor, D J; Lowery, A J; Kearney, D; McAnena, O J; Sweeney, K J; Kerin, M J

    2015-09-01

    The quality of abstracts presented at a conference reflects the academic activity and research productivity of the surgical/scientific association concerned. The abstract to publication rate (44.5 % internationally), is an important indicator of the quality of presented research. To evaluate the publication rate and impact of abstracts presented at the plenary session of the Sir Peter Freyer Surgical Symposium over a 25-year period (1989-2014), and identify factors influencing publication. Plenary abstracts were identified from abstract books of the Symposium from 1989-2014. The authors, institution, subspecialty and research subject were recorded. A Medline search with name of the first and last author, key words and content of all abstracts was conducted to identify related publications. The impact factor (IF) of the journal and the time to publication was recorded. 298 presented abstracts resulted in 168 publications (publication rate: 56 %). Basic Science research accounted for 80 % (n = 237) of the total number of presentations with the remaining 20 % (n = 61) being categorised as clinical research. Overall, cancer research accounted for 48 % of presented work. The average time to publication was 2 ± 7 years, while 11 % of all published studies achieved publication in the year of the symposium. The median impact factor for published research was 3.558 (IF range 0-39). These results indicate that the quality of papers presented at the Sir Peter Freyer Surgical Symposium compares favourably with international equivalents, making this meeting an important forum for Irish Academic Surgery.

  2. Aggregation of polyQ proteins is increased upon yeast aging and affected by Sir2 and Hsf1: novel quantitative biochemical and microscopic assays.

    Directory of Open Access Journals (Sweden)

    Aviv Cohen

    Full Text Available Aging-related neurodegenerative disorders, such as Parkinson's, Alzheimer's and Huntington's diseases, are characterized by accumulation of protein aggregates in distinct neuronal cells that eventually die. In Huntington's disease, the protein huntingtin forms aggregates, and the age of disease onset is inversely correlated to the length of the protein's poly-glutamine tract. Using quantitative assays to estimate microscopically and capture biochemically protein aggregates, here we study in Saccharomyces cerevisiae aging-related aggregation of GFP-tagged, huntingtin-derived proteins with different polyQ lengths. We find that the short 25Q protein never aggregates whereas the long 103Q version always aggregates. However, the mid-size 47Q protein is soluble in young logarithmically growing yeast but aggregates as the yeast cells enter the stationary phase and age, allowing us to plot an "aggregation timeline". This aging-dependent aggregation was associated with increased cytotoxicity. We also show that two aging-related genes, SIR2 and HSF1, affect aggregation of the polyQ proteins. In Δsir2 strain the aging-dependent aggregation of the 47Q protein is aggravated, while overexpression of the transcription factor Hsf1 attenuates aggregation. Thus, the mid-size 47Q protein and our quantitative aggregation assays provide valuable tools to unravel the roles of genes and environmental conditions that affect aging-related aggregation.

  3. The Professor and the Student, Sir Ronald Aylmer Fisher (1890-1962) and William Sealy Gosset (1876-1937): Careers of two giants in mathematical statistics.

    Science.gov (United States)

    Vyas, Shreena A; Desai, Sukumar P

    2015-05-01

    Sir Ronald Aylmer Fisher and William Sealy Gosset were responsible for laying the foundations of statistical inference. Tests that bear their names are used by students and researchers in a wide variety of scientific disciplines. Similar and different in many respects, their lives and careers are the subject of this essay. They were not teacher and pupil; in fact the student was 14 years older than the professor. Their careers did not require them to interact with one another much but they were aware of one another's work. Although Sir Ronald is assigned the role of the professor, his success as a teacher was impaired by his inability to understand the limitations of his students. Meanwhile Gosset was forced to publish his work under the pseudonym 'Student' in order to make contributions to the field of mathematical statistics. Both men are undisputed giants in the field of statistics and we celebrate their achievements as much as we try to understand their struggles. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  4. Physiologically-based, predictive analytics using the heart-rate-to-Systolic-Ratio significantly improves the timeliness and accuracy of sepsis prediction compared to SIRS.

    Science.gov (United States)

    Danner, Omar K; Hendren, Sandra; Santiago, Ethel; Nye, Brittany; Abraham, Prasad

    2017-04-01

    Enhancing the efficiency of diagnosis and treatment of severe sepsis by using physiologically-based, predictive analytical strategies has not been fully explored. We hypothesize assessment of heart-rate-to-systolic-ratio significantly increases the timeliness and accuracy of sepsis prediction after emergency department (ED) presentation. We evaluated the records of 53,313 ED patients from a large, urban teaching hospital between January and June 2015. The HR-to-systolic ratio was compared to SIRS criteria for sepsis prediction. There were 884 patients with discharge diagnoses of sepsis, severe sepsis, and/or septic shock. Variations in three presenting variables, heart rate, systolic BP and temperature were determined to be primary early predictors of sepsis with a 74% (654/884) accuracy compared to 34% (304/884) using SIRS criteria (p < 0.0001)in confirmed septic patients. Physiologically-based predictive analytics improved the accuracy and expediency of sepsis identification via detection of variations in HR-to-systolic ratio. This approach may lead to earlier sepsis workup and life-saving interventions. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1.

    Science.gov (United States)

    Zhao, Xuan; Lu, Lulu; Qi, Yonghao; Li, Miao; Zhou, Lijun

    2017-10-01

    The naturally occurring anthraquinone emodin has been serving primarily as an anti-bacterial and anti-inflammatory agent. However, little is known about its potential on anti-aging. This investigation examined the effect of emodin on lifespan and focused on its physiological molecular mechanisms in vivo. Using Caenorhabditis elegans (C. elegans) as an animal model, we found emodin could extend lifespan of worms and improve their antioxidant capacity. Our mechanistic studies revealed that emodin might function via insulin/IGF-1 signaling (IIS) pathway involving, specifically the core transcription factor DAF-16. Quantitative RT-PCR results illustrated that emodin up-regulated transcription of DAF-16 target genes which express antioxidants to promote antioxidant capacity and lifespan of worms. In addition, attenuated effect in sir-2.1 mutants suggests that emodin likely functioned in a SIR-2.1-dependent manner. Our study uncovers a novel role of emodin in prolonging lifespan and supports the understanding of emodin being a beneficial dietary supplement.

  6. Reconnaissance geologic mapping of a portion of the rain‐forest‐covered Guiana Shield, Northwestern Brazil, using SIR-B and digital aeromagnetic data

    Science.gov (United States)

    Pellon de Miranda, Fernando; McCafferty, Anne E.; Taranik, James V.

    1994-01-01

    This paper documents the result of an integrated analysis of spaceborne radar (SIR-B) and digital aeromagnetic data carried out in the heavily forested Guiana Shield. The objective of the research is to interpret the geophysical data base to its limit to produce a reconnaissance geologic map as an aid to ground work planning in a worst‐case setting. Linear geomorphic features were identified based on the interpretation of the SIR-B image. Digital manipulation of aeromagnetic data allowed the development of a color‐shaded relief map of reduced‐to‐pole magnetic anomalies, a terrace‐magnetization map, and a map showing the location of maximum values of the horizontal component of the pseudogravity gradient (magnetization boundary lines). The resultant end product was a reconnaissance geologic map where broad terrane categories were delineated and geologic faults with both topographic and magnetic expression were defined. The availability of global spaceborne radar coverage in the 1990s and the large number of existing digital aeromagnetic surveys in northwestern Brazil indicate that this approach can be potentially useful for reconnaissance geologic mapping elsewhere in the Guiana Shield.

  7. Long-lived impurities of 90Y-labeled microspheres, TheraSphere and SIR-spheres, and the impact on patient dose and waste management.

    Science.gov (United States)

    Metyko, John; Williford, John M; Erwin, William; Poston, John; Jimenez, Sandra

    2012-11-01

    Yittrium-90 microsphere brachytherapy procedures have increased in number due to their efficacy in treating some unresectable metastatic liver tumors. The discovery of long-lived impurities in two microsphere products, first reported between 2006 and 2007, has resulted in some radiation safety concerns. Since then, microsphere production processes have been refined, which reportedly lead to a reduction in detectable by-products. In this study unused vials of TheraSphere and SIR-Spheres, manufactured in early January 2011, were analyzed to identify and quantify the low-level radioactive impurities. Absorbed dose calculations were performed to assess the potential increased dose to the patient due to long-lived impurities. Results showed that while the SIR-Spheres vials contained no detectable impurities (contrary to other published results in the literature), the TheraSphere vials contained 17 radionuclides in one sample and 15 in the other. The dominant impurities were Y and Y, with specific activities ranging from 0.99 ± 3.40 × 10 kBq mg to 6.30 ± 0.40 kBq mg at vendor assay date. Other impurities were on the order of Bq mg. Based on Medical Internal Radiation Dose (MIRD) liver and lung dose estimates, the long-lived impurities would be expected to increase an administered dose by less than 0.1% from the prescribed dose.

  8. Comparison of the Adverse Event Profile of TheraSphere® with SIR-Spheres® for the Treatment of Unresectable Hepatocellular Carcinoma: A Systematic Review.

    Science.gov (United States)

    Kallini, Joseph Ralph; Gabr, Ahmed; Thorlund, Kristian; Balijepalli, Chakrapani; Ayres, Dieter; Kanters, Steve; Ebrahim, Shanil; Mills, Edward; Lewandowski, Robert J; Salem, Riad

    2017-07-01

    To compare the safety profiles of TheraSphere ® (glass) and SIR-Spheres ® (resin) Y90 microspheres for the treatment of hepatocellular carcinoma. A systematic review was conducted using the databases MEDLINE, Embase, and Cochrane Trials Register to identify all relevant studies. Baseline characteristics and adverse events of all grades related to gastrointestinal, hepatobiliary, and respiratory systems were collected along with commonly reported outcomes related to post-embolization syndrome. For all outcomes, data from each study were tabulated for each intervention. Adverse events and patients were summed across studies on TheraSphere ® and SIR-Spheres ® , respectively, and the resulting proportion of patients experiencing an outcome for both interventions was calculated. Thirty-one observational studies were included in the review. In the adverse events of all grades, more patients treated with resin microspheres reported gastric ulcers, hepatic encephalopathy, cholecystitis, hepatic failure, and pleural effusion. Patients treated with resin microspheres also had more hepatobiliary adverse events of grade 3 or higher. In the events related to post-embolization syndrome, glass microspheres exhibited a similar safety profile compared to resin microspheres. Ascites and nausea grade 3 or higher were recorded more frequently with glass microsphere treatment. Based on this review of the published literature, glass microspheres exhibit a safety profile with fewer gastrointestinal and pulmonary adverse events compared to resin microspheres in the treatment of hepatocellular carcinoma.

  9. Paleodrainages of the Eastern Sahara - The radar rivers revisited (SIR-A/B implications for a mid-tertiary Trans-African drainage system)

    Science.gov (United States)

    Mccauley, J. F.; Breed, C. S.; Schaber, G. G.; Mchugh, W. P.; Haynes, C. C.

    1986-01-01

    The images obtained by the Shuttle Imaging Radar (SIR)-A and -B systems over the southwestern Egypt and northwestern Sudan were coregistered with the Landsat images and the existing maps to aid in extrapolations of the buried paleodrainages ('radar rivers'), first discovered by SIR-A. Field observations explain the radar responses of three types of radar rivers, RR-1 (broad, aggraded valleys filled with alluvium), RR-2 (braided channels inset in the RR-1 valleys), and RR-3 (narrow, long, bedrock-incised channels). A generalized model of the radar rivers, based on field studies and regional geologic relations, shows inferred changes in river regimen since the large valleys were established during the later Paleogene-early Neogene. It is suggested that a former Trans-African master stream system may have flowed from headwaters in the Red Sea Hills southwestward across North Africa, discharging into the Atlantic at the Paleo-Niger delta, prior to the Neogene domal uplifts and building of volcanic edifices across the paths of these ancient watercourses.

  10. Passacaglia van J.S. Bach en Das Passagen-Werk van Walter Benjamin - literêre montage as mosaïekwerk in Memorandum. 'n Verhaal met skilderye (2006)

    OpenAIRE

    van Vuuren, Helize

    2014-01-01

    Van Niekerk se Memorandum-narratief is 'n gedenkskrif vir die elegies-realistiese skilder, Adriaan van Zyl, wat in September 2006 sterf - soos Walter Benjamin in sy laat veertigs en insgelyks met sy kunstenaarsloopbaan onderbreek. Van Niekerk stel in Memorandum vir haarself 'n uitdagende taak (soos Wiid dit formuleer aan die begin van "Memorandum 3"): om Bach se Passacaglia en fuga in C Mineur (BWV 582) (± 1715) te "vertaal" in prosa en om 'n kleiner, Afrikaanse weergawe van Benjamin se Das P...

  11. Blanco White and Walter Scott Blanco white y Walter Scott

    Directory of Open Access Journals (Sweden)

    Fernando DURÁN LÓPEZ

    2011-01-01

    Full Text Available The first edition of Ivanhoe; a romance. By the author of Waverley was published in Edinburgh in 1820. From the beginning of year 1823, José María Blanco White translated several excerpts from Ivanhoe in the numbers 1-3 of the magazine Variedades, owned by the publisher Rudolph Ackermann. in these articles and other later writings, the translator praised Scott as a model for a new way of painting history in a narrative. This paper studies his ideas on Scott’s historical novel, as well as his translation technique, compared with that of José Joaquín de Mora. En 1820 se publicó en Edimburgo la primera edición de Ivanhoe; a romance. By the author of Waverley. Desde comienzos de 1823, en los tres primeros números de su revista Variedades, promovida por el editor Rudolph Ackermann, José María Blanco White tradujo varios fragmentos de Ivanhoe entre grandes elogios. Asimismo, Blanco White tomó a Scott como modelo de referencia de una nueva manera de pintar la historia por medio de la novela en otros varios escritos críticos de años posteriores. El artículo estudia las ideas de Blanco White acerca de la novela histórica de Scott y su técnica como traductor, comparada con la de José Joaquín Mora.

  12. Peer-Assisted Learning Programme: Supporting Students in High-Risk Subjects at the Mechanical Engineering Department at Walter Sisulu University

    Directory of Open Access Journals (Sweden)

    Makala Qonda

    2017-12-01

    Full Text Available The majority of the students who enroll at the Walter Sisulu University (WSU in South Africa are not equipped with the necessary academic/learning skills to cope with the university environment, especially in Mechanical Engineering. The Department of Higher Education and Training (2013, p. 17, further states that “students’ support is crucial to ensure that students adapt to the demands of college life and that they can meet the demands of college programmes”. Particularly in South Africa, the school environment might also contribute to poor student performance as a result of insufficient student support, and a lack of facilities and resources. In order to address this gap, a Peer-Assisted Learning (PAL programme was implemented to provide support targeting high-risk subjects for at-risk students in Mechanical Engineering at WSU. The programme therefore is pro-active and student-driven in that senior students assist junior students with their academic work and learning processes. The programme is designed to encourage collaborative and cooperative learning approaches during group sessions and active student engagement to support student learning (Laal & Laal, 2012. The programme requires substantial resources and time commitments. It is important from an operational, learning, and student perspective to understand in what ways the PAL programme assists students (if at all. Eliciting the experiences of students also helps the department to design interventions from a student-centred perspective using the lens of learning theories.  This qualitative case study explores the student experience of the Peer-Assisted Learning (PAL programme. Open-ended questionnaires/survey from 20 first-year students elicited their perceptions and experiences of the PAL programme. Responses were analysed thematically. Findings indicated that the students had useful insights that may contribute to revising the programme. Aspects mentioned were improved study

  13. El Mediterráneo a través de la ficción: el extraño caso de Sir John Mandeville

    Directory of Open Access Journals (Sweden)

    Morales Osorio, Susana

    2006-06-01

    Full Text Available

    The Travels of Sir John Mandeville presents the ficticious construction of the Orient through a travels tale which is primarily shaped as a pilgrimage to Jerusalem. Over and above the critical controversy about the existence of Sir John Mandeville, this book depicts in a very accurate way several key topics in the literature of the Middle Ages as it is the conception of the travel through the medieval peregrination, the homo viator as a consequence of the religious becoming which steamed the Middle Ages, or the Bible as the geography of the known world and the destination of the medieval curiosity. On the other hand, the tale shows a very special devising of the Other, of the unknown, by means of a mythical perspective, that is, through the recreation of fascinating mirabilia collection that still impress the current reader.



    Los viajes de Sir John Mandeville presenta la construcción ficticia del Oriente a través de un relato de viajes que se configura en primera instancia como una peregrinación a Jerusalén. La concepción del viaje a través de la peregrinatio medieval, el homo viator como consecuencia del devenir religioso que empaña la Edad Media, la Biblia como geografía del mundo conocido y como destino de la curiosidad medieval, tienen en la figura narrativa del Libro de las Maravillas del Caballero Sir John Mandeville una de sus mejores articulaciones, al margen de los problemas y

  14. Adaptive Roles of SSY1 and SIR3 During Cycles of Growth and Starvation in Saccharomyces cerevisiae Populations Enriched for Quiescent or Nonquiescent Cells.

    Science.gov (United States)

    Wloch-Salamon, Dominika M; Tomala, Katarzyna; Aggeli, Dimitra; Dunn, Barbara

    2017-06-07

    Over its evolutionary history, Saccharomyces cerevisiae has evolved to be well-adapted to fluctuating nutrient availability. In the presence of sufficient nutrients, yeast cells continue to proliferate, but upon starvation haploid yeast cells enter stationary phase and differentiate into nonquiescent (NQ) and quiescent (Q) cells. Q cells survive stress better than NQ cells and show greater viability when nutrient-rich conditions are restored. To investigate the genes that may be involved in the differentiation of Q and NQ cells, we serially propagated yeast populations that were enriched for either only Q or only NQ cell types over many repeated growth-starvation cycles. After 30 cycles (equivalent to 300 generations), each enriched population produced a higher proportion of the enriched cell type compared to the starting population, suggestive of adaptive change. We also observed differences in each population's fitness suggesting possible tradeoffs: clones from NQ lines were better adapted to logarithmic growth, while clones from Q lines were better adapted to starvation. Whole-genome sequencing of clones from Q- and NQ-enriched lines revealed mutations in genes involved in the stress response and survival in limiting nutrients ( ECM21 , RSP5 , MSN1 , SIR4 , and IRA2 ) in both Q and NQ lines, but also differences between the two lines: NQ line clones had recurrent independent mutations affecting the Ssy1p-Ptr3p-Ssy5p (SPS) amino acid sensing pathway, while Q line clones had recurrent, independent mutations in SIR3 and FAS1 Our results suggest that both sets of enriched-cell type lines responded to common, as well as distinct, selective pressures. Copyright © 2017 Wloch-Salamon et al.

  15. Sir Archibald Hector McIndoe (1900-1960) and the Guinea Pig Club: the development of reconstructive surgery and rehabilitation in the Second World War (1939-1945).

    Science.gov (United States)

    Macnamara, Alexandra F; Metcalfe, Neil H

    2014-11-01

    This article discusses the work of pioneering surgeon Sir Archibald McIndoe and particularly his reconstructive surgery and patient-centred approach during the Second World War. It also covers how this affected the lives of his patients and the subsequent formation of the Guinea Pig Club. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  16. Top man: Mathematician, geographer, vice chancellor , Sir Alan Wilson the new director general of higher education at the DfES, has a reputation for solving complicated problems. He talks to Jim Kelly

    CERN Multimedia

    Kelly, J

    2003-01-01

    "Sir Alan Wilson, vice-chancellor of Leeds University, has made a career out of solving big problems. This week he landed himself one of the biggest. Appointed the government's first ever director general of higher education, he becomes responsible for advising Charles Clarke at a pivotal moment in the history of the sector" (1 page).

  17. In Search of Lost Community: The Literary Image between “Proust” and “Baudelaire” in Walter Benjamin’s Modernization Lament

    Directory of Open Access Journals (Sweden)

    Karyn Ball

    2015-02-01

    Full Text Available This essay takes up the encounter between philosophy and literature through a reconsideration of Walter Benjamin’s remarks from “On Some Motifs in Baudelaire” about Henri Bergson’s Matière et mémoire as an attempt “[t]owering above” other ventures into Lebensphilosophie to “lay hold of the ‘true’ experience, as opposed to the kind that manifests itself in the standardized, denatured life of the civilized masses”. Despite his initial affirmation of Bergson’s understanding of experience as connected with tradition, Benjamin criticizes the philosopher’s account for sidestepping “the alienating, blinding experience of the age of large-scale industrialism” in reaction to which, as Benjamin insists, Bergson’s philosophy of memory developed. Yet even as Bergson shuts out the historical import of modernization, according to Benjamin, he also spotlights a “complementary” visual experience “in the form of its spontaneous afterimage”. Benjamin subsequently defines Bergson’s philosophy as “an attempt to specify this afterimage and fix it as a permanent record”, an endeavor that inadvertently “furnishes a clue to the experience which presented itself undistorted to Baudelaire’s eyes, in the figure of his reader”. If the literary critic might be viewed here as weighing in on a long-running antagonism between philosophy and literature, then his assessment is resolute: by praising the self-conscious historicity of Baudelaire’s lyric, Benjamin declares that poetry succeeds where Lebensphilosophie fails. Notably, Baudelaire is not the only figure to upstage “ahistorical” Bergson, since Marcel Proust and Sigmund Freud facilitate this victory. To contextualize the second section of “Motifs”, where Benjamin discusses the novelist’s “immanent critique of Bergson” this essay offers a reading of “On the Image of Proust” as a propadeutic to Benjamin’s privileging of “Baudelaire” over

  18. Bouvard et Pécuchet et le ruban de Möbius. Variation mathématique sur le désir

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    Florence Pellegrini

    2010-09-01

    Full Text Available Lorsqu’ils se rencontrent par un après-midi de dimanche désœuvré sur le désertique boulevard Bourdon, Bouvard et Pécuchet connaissent le séisme d’un coup de foudre. Complémentaires, antithétiques mais harmoniques, le veuf sans enfants et le célibataire résolvent la solitude de leurs existences dans cette providentielle rencontre qui les accouple définitivement : protagoniste bicéphale, Bouvard et Pécuchet constituent une entité insécable fonctionnant par renvois, correspondances, symétries inversées. On a beaucoup glosé sur l’homosexualité supposée des personnages. Toujours ensemble, jusqu’au plus intime de leur chambre communicante à défaut d’être commune, contraires s’attirant jusqu’à se fondre, les deux héros pourraient se perdre en eux-mêmes, tout à leur « domesticité conjugale ». Chacun se voit pourtant attribuer une aventure sentimentale autonome : au blagueur Bouvard, la veuve Bordin sanglée dans sa robe de soie gorge-pigeon ; au timide Pécuchet, puceau tardif et indécis, la petite bonne Mélie, qui ne tardera pas à lui transmettre la syphilis.Toutefois ces aventures comptent peu dans l’économie globale du roman. Ou plutôt comptent au même titre que les innombrables expériences auxquelles se livrent les bonshommes dont le seul véritable désir semble bien être un désir de connaissance. Tels de nouveaux Frédéric Moreau dont le désir de posséder physiquement Marie Arnoux est comme résorbé – transcendé ? – dans « une curiosité douloureuse qui n’avait pas de limites », Bouvard et Pécuchet semblent passés maîtres dans l’art du déplacement et de la sublimation. Rendus dans un au-delà du désir qui pourrait bien être un absolu du désir, les personnages nourrissent leur libido sciendi de la mutabilité de ses objets. Amants inconstants ou amateurs velléitaires découragés à la première difficulté – l’échec les détourne de l’objet de leur

  19. Los usos comerciales de la caricatura en Cuba: Conrado Walter Massaguer y la revista 'Cinelandia' como dispositivo para la construcción de la hegemonía del 'start system' hollywoodense en la isla

    Directory of Open Access Journals (Sweden)

    Rainer Rubira García

    2011-06-01

    Full Text Available El texto propone un análisis histórico-crítico de la evolución de la imagen visual en el marco de la cultura de masas y, en particular, de la caricatura en Cuba como dispositivo de construcción de ideología en distintas épocas. Se centra en la figura del comunicador visual Conrado Walter Massaguer y uno de sus proyectos comerciales de revista: Cinelandia, así como el contexto en que emergió. Por último se explican algunas de las estrategias discursivas utilizadas por la publicación para la consolidación de la hegemonía norteamericana en Cuba a través de las estrellas del cine de Hollywood en la década de 1920, estrategias basadas ante todo en el plano visual, en especial, en los usos ideológicos de la caricatura.

  20. MELANCOLÍA Y FLEMA (CONCEPCIONES HUMORALISTAS EN TORNO A LA NOCIÓN DE MELANCOLÍA EN "EL ORIGEN DEL TRAUERSPIEL ALEMÁN" DE WALTER BENJAMIN

    Directory of Open Access Journals (Sweden)

    Juan Horacio de Freitas

    2013-12-01

    Full Text Available If something is usually considered to be remarkable about “The origin of German tragic drama”, a book written by Walter Benjamin in order to be a postulant as a teacher at the University, is its conceptual richness and innovation. This essay tries to accomplish two objectives: On the one hand, to understand the sense of one of these notions, that of melancholy, which is so important for Benjamin both in this work and all along his philosophical production. On the other hand, an attempt is made to investigate both implicit and explicit sources used by the philosopher to refer to the term under consideration. This will lead us to deal with classic medicine authors such as Hippocrates and Galen, from the renacentist astrological ideological repertoire such as Ficino and some Freudian proposals about mourning and melancholy.

  1. A janela da palavra: uma leitura de “Famigerado”, de Guimarães Rosa, à luz do conceito de limiar, de Walter Benjamin DOI - 10.5752/P.2358-3428.2012v16n31p185

    Directory of Open Access Journals (Sweden)

    Edson Santos de Oliveira

    2012-12-01

    Full Text Available Nosso objetivo é fazer uma leitura do conto "Famigerado", de Guimarães Rosa, a partir do conceito de limiar, conforme Walter Benjamin. Pretendemos articular esse conceito com uma das categorias estéticas mais estudadas na obra de Guimarães Rosa: a ambiguidade. Assim, o espaço de transição em que se dá a narrativa se integra ao corpo ambíguo da linguagem, possibilitando não só a emergência de chistes por parte do jagunço Damásio, como também propiciando ao personagem-narrador uma oportunidade de se equilibrar no limiar da significação. Se o conceito de limiar em Benjamin permite um pensamento por imagem, processo semelhante ocorre na escrita rosiana.  Palavras-chave: Limiar. Ambiguidade escrita. Imagem.

  2. Distracción, shock, interrupción: la recepción de Walter Benjamin en las prácticas artísticas contemporáneas

    OpenAIRE

    Castellano, Tania

    2016-01-01

    Nuestra investigación parte de la intrigante expresión “recepción en la distracción” que Walter Benjamin introduce en todas las versiones del ensayo titulado “La obra de arte en la época de su reproductibilidad técnica” (1935-1939). Con ella define un nuevo modo perceptivo presente en la modernidad. Pese a que antes de este ensayo Benjamin asumiera la percepción distraída en un sentido negativo, a partir de él arroja una nueva luz sobre el término distracción y lo defiende ante sus detractore...

  3. La puesta en escena de la autenticidad. Andalucía, un siglo de fascinación, de Basilio Martín Patino, y el “materialismo histórico” en Walter Benjamin

    Directory of Open Access Journals (Sweden)

    Cornago Bernal, Óscar

    2011-04-01

    Full Text Available This article explores the theatrical estrategies that documentary genre develops to create an effect of reality. For this aim it will be analyzed the Basilio Martín Patino’s production for television Andalucía, a century of fascination, a serie of five documentaries filmed from 1992 to 1996 for the public channel Canal Sur Television. These films will be compared to previous work of Martin Patino and to other critics and directors’ points of view regarding documentary genre and simulation of objetivity in visual media. As methodology it will be discus the concept of “materialist history” in Walter Benjamin.

    Este artículo explora las estrategias teatrales desarrolladas por el género documental para crear un efecto de realidad. Con este objetivo se analizará la producción para televisión de Basilio Martín Patino Andalucía, un siglo de fascinación, una serie de cinco documentales filmados entre 1992 y 1996 para la cadena pública Canal Sur Televisión. Estas películas serán comparadas con trabajos anteriores de Martín Patino y con el punto de vista de críticos y directores en relación a las prácticas documentales y la creación de un efecto de objetividad en los medios audiovisuales. Como metodología se aplicará el concepto de “historia material” desarrollado por Walter Benjamin.

  4. Software de simulações dos modelos Sir e Seir como ferramenta de gerenciamento ambiental de doenças epidemiológicas

    Directory of Open Access Journals (Sweden)

    Ranaya Silva Barbosa

    2016-10-01

    Full Text Available As epidemias têm causado pânico em todo o mundo desde a antiguidade, nos dias de hoje a dengue, zika vírus e a chikungunya tem sido alvo de grande preocupação nacional. Observa-se, portanto, a importância de se compreender a dinâmica de transmissão dessas doenças através da técnica de investigação por modelos matemáticos, uma vez que este método não interfere no meio estudado. Visando auxiliar no gerenciamento ambiental por meio da compreensão da dinâmica das epidemias, captura do comportamento qualitativo do modelo e dos parâmetros que podem influenciar significativamente no processo de transmissão, foi desenvolvido um software de simulação dos modelos SIR e SEIR empregando o Método de Integração Numérica de Runge-Kutta de 4ª ordem implementado em linguagem de programação JAVA.

  5. Shuttle imaging radar-A (SIR-A) data analysis. [geology of the Ozark Plateau of southern Missouri, land use in western Illinois, and vegetation types at Koonamore Station, Australia

    Science.gov (United States)

    Arvidson, R. E.

    1983-01-01

    The utility of shuttle imaging radar (SIR-A) data was evaluated in several geological and environmental contexts. For the Ozark Plateau of southern Missouri, SIR-A data were of little use in mapping structural features, because of generally uniform returns. For western Illinois, little was to be gained in terms of identifying land use categories by examining differences between overlapping passes. For southern Australia (Koonamore Station), information ion vegetation types that was not obtainable from LANDSAT MSS data alone was obtained. Specifically, high SIR-A returns in the Australian site were found to correlate with locations where shrubs increase surface roughness appreciably. The Australian study site results demonstrate the synergy of acquiring spectral reflectance and radar data over the same location and time. Such data are especially important in that region, since grazing animals have substantially altered and are continuing to alter the distribution of shrublands, grasslands, and soil exposures. Periodic, synoptic acquisition of MSS and SAR data would be of use in monitoring the dynamics of land-cover change in this environment.

  6. Le désir au féminin : d’une « Lucrèce » à une autre

    Directory of Open Access Journals (Sweden)

    Jacqueline Fabre-Serris

    2010-11-01

    Full Text Available Cet article propose deux hypothèses. La première est celle d’une réception élégiaque du célèbre portrait livien de Lucrèce dans l’élégie 1, 3 de Tibulle. La fin de l’élégie 1, 3 constitue une variation sur un motif des Amores (la séparation des amants due à l’absence de l’homme, retenu au loin que Virgile avait évoqué dans la Bucolique 10. Dans ce passage Tibulle apporte à la question « comment se comporte alors la puella ? » une réponse inspirée par l’image que Tite-Live venait de donner, avec sa Lucrèce, de la vertu des femmes, réponse qui infléchit la scène livienne dans le sens de la passion. La seconde hypothèse est que le texte de Tibulle a été la matrice de plusieurs autres textes centrés sur la séparation, la fidélité et le désir féminin : les poèmes 3, 9 ; 3, 14 et 15 de Sulpicia ; les élégies 1, 3 ; 2, 29 et 4, 3 de Properce et le passage des Fastes consacré à Lucrèce.

  7. Assessment of current burden of human rabies at Sir Ronald Ross Institute of Tropical and Communicable Diseases (Government Fever Hospital – Five year study

    Directory of Open Access Journals (Sweden)

    Dukkipati Kalyani

    2017-01-01

    Full Text Available Human rabies has been still endemic in India. There are an increasing number of studies estimating the burden of human rabies, but the true incidence of the disease and endemicity were rarely reported in the literature. The main objectives of the present study were to determine the endemicity and to estimate the current burden of human rabies in and around Sir Ronald Ross Institute of Tropical and Communicable Diseases (SRRIT & CD, Nallakunta, Hyderabad. All cases admitted at SRRIT & CD with signs and symptoms of rabies were studied during the period of January 2009 and December 2013. The annual incidence of human rabies in this hospital was estimated to be 152. It is endemic mainly in urban areas that include many areas in Hyderabad and Secunderabad and also adjacent districts. The majority of the patients were children and adult male, from urban areas, and had not taken post exposure prophylaxis (PEP i.e. wound care, active immunization (ARV and passive immunization (RIG. The main animals responsible for bites were dogs (99%, most of which were stray and the most common bite sites were the extremities. Most common clinical feature was hydrophobia. About 92.76% of these patients had not taken PEP. Human rabies continues to be a dreadful disease in India and the dogs are the principal reservoir, mainly stray dogs. This study provides strong evidence that human rabies is still an endemic disease even in urban areas. This is mainly due to lack of awareness about proper PEP. Improved coverage with modern rabies vaccines, control of rabies due to dogs and other animals and intensifying public education about the disease play main role in the reduction of the disease. [J Med Allied Sci 2017; 7(1.000: 14-19

  8. Bayesian estimation of the dynamics of pandemic (H1N1) 2009 influenza transmission in Queensland: A space-time SIR-based model.

    Science.gov (United States)

    Huang, Xiaodong; Clements, Archie C A; Williams, Gail; Mengersen, Kerrie; Tong, Shilu; Hu, Wenbiao

    2016-04-01

    A pandemic strain of influenza A spread rapidly around the world in 2009, now referred to as pandemic (H1N1) 2009. This study aimed to examine the spatiotemporal variation in the transmission rate of pandemic (H1N1) 2009 associated with changes in local socio-environmental conditions from May 7-December 31, 2009, at a postal area level in Queensland, Australia. We used the data on laboratory-confirmed H1N1 cases to examine the spatiotemporal dynamics of transmission using a flexible Bayesian, space-time, Susceptible-Infected-Recovered (SIR) modelling approach. The model incorporated parameters describing spatiotemporal variation in H1N1 infection and local socio-environmental factors. The weekly transmission rate of pandemic (H1N1) 2009 was negatively associated with the weekly area-mean maximum temperature at a lag of 1 week (LMXT) (posterior mean: -0.341; 95% credible interval (CI): -0.370--0.311) and the socio-economic index for area (SEIFA) (posterior mean: -0.003; 95% CI: -0.004--0.001), and was positively associated with the product of LMXT and the weekly area-mean vapour pressure at a lag of 1 week (LVAP) (posterior mean: 0.008; 95% CI: 0.007-0.009). There was substantial spatiotemporal variation in transmission rate of pandemic (H1N1) 2009 across Queensland over the epidemic period. High random effects of estimated transmission rates were apparent in remote areas and some postal areas with higher proportion of indigenous populations and smaller overall populations. Local SEIFA and local atmospheric conditions were associated with the transmission rate of pandemic (H1N1) 2009. The more populated regions displayed consistent and synchronized epidemics with low average transmission rates. The less populated regions had high average transmission rates with more variations during the H1N1 epidemic period. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Studies on the use of SIR-C and X-SAR data for identification, demarcation, and assessment of forest ecosystems. Final report; Untersuchungen zum Einsatz von SIR-C und X-SAR Daten fuer die Identifizierung, Abgrenzung und Beurteilung von Waldoekosystemen. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Johlige, A.; Foerster, B.; Ammer, U.

    1997-12-31

    The purpose of the present evaluation was to use SIR-C and X-SAR data for forest surveying and assess their suitability for this task. Amongst other work this included the discrimination of forest and non-forest, demarcation of cleared areas within forests, discrimination of different forest types, and assessment of the influence of foliation. The chief steps of the study were the preparation of radar data, accompanying aerial photo evaluation for the extraction of training and verification areas, and detailed signature analysis. Evaluation trials in ``Oberpfaffenhofen`` supertest area yielded unsatisfactory results when it came to discriminating different forest ecosystems. This can be attributed to the very heterogeneous and small-scale structure of the area and the absence of topographically coded X, C, and L band data. In the second study area, located in the ``Bavarian Forest National Park``, geocoded data of all three bands were available in the form of combined products. This permitted using the mask of the local angles of incidence to reduce the influence of relief. In this case distinguishability within wooded regions was also enhanced. A general finding was that ground resolution as it presents to the user is clearly poorer than the nominal resolution. What impressed us most was the high degree of weather-independence of the radar data. All data handled in this study were recorded under conditions that would have made photography impossible. (orig.) [Deutsch] Ziel der Auswertung ist es SIR-C/X-SAR Daten fuer die Waldbeobachtung einzusetzen und ihre Eignung dafuer zu bewerten. Zu loesende Teilaufgaben waren u.a. die Wald-Nichtwaldtrennung, die Abtrennung unbestockter Flaechen im Wald, Unterscheidung verschiedener Waldtypen selbst und die Beurteilung des Einflusses des Belaubungszustndes. Die zentralen Arbeitsschritte waren die Aufbereitung der Radardaten, die begleitende Luftbildauswertung zur Extraktion von Trainings- und Verifizierungsgebieten und die

  10. Studies on the use of SIR-C and X-SAR data for identification, demarcation, and assessment of forest ecosystems. Final report; Untersuchungen zum Einsatz von SIR-C und X-SAR Daten fuer die Identifizierung, Abgrenzung und Beurteilung von Waldoekosystemen. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Johlige, A; Foerster, B; Ammer, U

    1998-12-31

    The purpose of the present evaluation was to use SIR-C and X-SAR data for forest surveying and assess their suitability for this task. Amongst other work this included the discrimination of forest and non-forest, demarcation of cleared areas within forests, discrimination of different forest types, and assessment of the influence of foliation. The chief steps of the study were the preparation of radar data, accompanying aerial photo evaluation for the extraction of training and verification areas, and detailed signature analysis. Evaluation trials in ``Oberpfaffenhofen`` supertest area yielded unsatisfactory results when it came to discriminating different forest ecosystems. This can be attributed to the very heterogeneous and small-scale structure of the area and the absence of topographically coded X, C, and L band data. In the second study area, located in the ``Bavarian Forest National Park``, geocoded data of all three bands were available in the form of combined products. This permitted using the mask of the local angles of incidence to reduce the influence of relief. In this case distinguishability within wooded regions was also enhanced. A general finding was that ground resolution as it presents to the user is clearly poorer than the nominal resolution. What impressed us most was the high degree of weather-independence of the radar data. All data handled in this study were recorded under conditions that would have made photography impossible. (orig.) [Deutsch] Ziel der Auswertung ist es SIR-C/X-SAR Daten fuer die Waldbeobachtung einzusetzen und ihre Eignung dafuer zu bewerten. Zu loesende Teilaufgaben waren u.a. die Wald-Nichtwaldtrennung, die Abtrennung unbestockter Flaechen im Wald, Unterscheidung verschiedener Waldtypen selbst und die Beurteilung des Einflusses des Belaubungszustndes. Die zentralen Arbeitsschritte waren die Aufbereitung der Radardaten, die begleitende Luftbildauswertung zur Extraktion von Trainings- und Verifizierungsgebieten und die

  11. Remembering Sir J C Bose

    Indian Academy of Sciences (India)

    for this wonderful gift to Indian science. I would like to end this review with another quote for C. N. R. Rao's inspiring foreword. 'The book brings out the spirit of J. C. Bose and the flavour of the great man. I do hope it will be read by a large number of people, particularly young people of India.' M S Swaminathan, UNESCO ...

  12. Sir Almroth Wright: pioneer immunologist.

    Science.gov (United States)

    Ellis, Harold

    2011-03-01

    This year marks the 150th anniversary of the birth of Almroth Edward Wright, whose pioneer work in immunology saved countless lives, especially in the First World War, but whose name and work are all but forgotten today. Wright was born in 1861 in Middleton Tyas, Yorkshire, where his father, an Irish protestant and considerable Hebrew scholar, was the minister. Almroth's Swedish mother, the daughter of NW Almroth, governor of the mint in Stockholm, was responsible for his unusual first name. She had the rare distinction of having served as a nurse with Florence Nightingale in the hospital at Scutari in the Crimean War.

  13. Low sensitivity of qSOFA, SIRS criteria and sepsis definition to identify infected patients at risk of complication in the prehospital setting and at the emergency department triage.

    Science.gov (United States)

    Tusgul, Selin; Carron, Pierre-Nicolas; Yersin, Bertrand; Calandra, Thierry; Dami, Fabrice

    2017-11-03

    Sepsis is defined as life-threatening organ dysfunction caused by a host response to infection. The quick SOFA (qSOFA) score has been recently proposed as a new bedside clinical score to identify patients with suspected infection at risk of complication (intensive care unit (ICU) admission, in-hospital mortality). The aim of this study was to measure the sensitivity of the qSOFA score, SIRS criteria and sepsis definitions to identify the most serious sepsis cases in the prehospital setting and at the emergency department (ED) triage. We performed a retrospective study of all patients transported by emergency medical services (EMS) to the Lausanne University Hospital (CHUV) over twelve months. All patients with a suspected or proven infection after the ED workup were included. We retrospectively analysed the sensitivity of the qSOFA score (≥2 criteria), SIRS criteria (≥2 clinical criteria) and sepsis definition (SIRS criteria + one sign of organ dysfunction or hypoperfusion) in the pre-hospital setting and at the ED triage as predictors of ICU admission, ICU stay of ≥3 days and early (i.e. 48 h) mortality. No direct comparison between the three tools was attempted. Among 11,411 patients transported to the University hospital, 886 (7.8%) were included. In the pre-hospital setting, the sensitivity of qSOFA reached 36.3% for ICU admission, 17.4% for ICU stay of three days or more and 68.0% for 48 h mortality. The sensitivity of SIRS criteria reached 68.8% for ICU admission, 74.6% for ICU stay of three days or more and 64.0% for 48 h mortality. The sensitivity of sepsis definition did not reach 60% for any outcome. At ED triage, the sensitivity of qSOFA reached 31.2% for ICU admission, 30.5% for ICU stay of ≥3 days and 60.0% for mortality at 48 h. The sensitivity of SIRS criteria reached 58.8% for ICU admission, 57.6% for ICU stay of ≥3 days 80.0% for mortality at 48 h. The sensitivity of sepsis definition reached 60.0% for 48 h mortality. Incidence

  14. Royal Jelly-Mediated Prolongevity and Stress Resistance in Caenorhabditis elegans Is Possibly Modulated by the Interplays of DAF-16, SIR-2.1, HCF-1, and 14-3-3 Proteins.

    Science.gov (United States)

    Wang, Xiaoxia; Cook, Lauren F; Grasso, Lindsay M; Cao, Min; Dong, Yuqing

    2015-07-01

    Recent studies suggest that royal jelly (RJ) and its related substances may have antiaging properties. However, the molecular mechanisms underlying the beneficial effects remain elusive. We report that the effects of RJ and enzyme-treated RJ (eRJ) on life span and health span in Caenorhabditis elegans (C elegans) are modulated by the sophisticated interplays of DAF-16, SIR-2.1, HCF-1, and 14-3-3 proteins. Dietary supplementation with RJ or eRJ increased C. elegans life span in a dose-dependent manner. The RJ and eRJ consumption increased the tolerance of C elegans to oxidative stress, ultraviolet irradiation, and heat shock stress. Our genetic analyses showed that RJ/eRJ-mediated life-span extension requires insulin/IGF-1 signaling and the activities of DAF-16, SIR-2.1, HCF-1, and FTT-2, a 14-3-3 protein. Earlier studies reported that DAF-16/FOXO, SIR-2.1/SIRT1, FTT-2, and HCF-1 have extensive interplays in worms and mammals. Our present findings suggest that RJ/eRJ-mediated promotion of longevity and stress resistance in C elegans is dependent on these conserved interplays. From an evolutionary point of view, this study not only provides new insights into the molecular mechanisms of RJ's action on health span promotion in C elegans, but also has imperative implications in using RJ/eRJ as nutraceuticals to delay aging and age-related disorders. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  15. Juventud, memoria y derechos en tiempos de crisis. Una reflexión desde la crítica literaria de Walter Benjamin y la generación perdida de “Historias del Kronen”

    Directory of Open Access Journals (Sweden)

    Albert Noguera Fernández

    2014-07-01

    Full Text Available A partir de la obra del crítico literario Walter Benjamin el presente artículo explica cómo la recuperación de la Memoria histórica y su conexión con el presente constituye un elemento indispensable para poder construir un proyecto político colectivo capaz de recuperar la democracia, los derechos y la justicia social hoy desmantelados con la muerte del Estado constitucional en Europa. Este objetivo implica poner sobre la mesa dos cuestiones complejas. La primera es la implicación en este proyecto de una generación de jóvenes desencantada que ha roto todos los lazos con los valores políticos y sociales de las generaciones anteriores y que construye sus referentes vitales y modelos a seguir a través del consumismo y sus imaginarios. Generación descrita muy sugerentemente por la novela, después película, Historias del Kronen. La segunda es la referida a los usos o tratamiento que hay que dar a la Memoria para convertirla en un instrumento útil para el fin planteado.

  16. "Estetização da política e politização da arte": a estética do fascismo nas obras de Walter Benjamin

    Directory of Open Access Journals (Sweden)

    Rui Bragado Sousa

    2015-07-01

    Full Text Available O artigo examina a ascensão do fascismo na Alemanha a partir da estética de Walter Benjamin e propõe, ao final, um diálogo com Ernst Bloch. O método visa escapar de interpretações meramente econômicas que supostamente possibilitaram a chegada de Hitler ao poder. Procura-se um campo semântico mais vasto, dialético, como os conceitos utilizados por Benjamin como messianismo, alegoria e origem (ursprung. A “origem” é um protofenômeno no sentido teológico, quer seja ele o Paraíso ou o comunismo primitivo, uma idade edênica e igualitária na Terra. Literalmente são “saltos” para fora da continuidade histórica linear que rompem com o desenvolvimento meramente evolucionista da História. Com uma catástrofe iminente era necessário explodir o continuum da história.

  17. A prospective evaluation of treatment with Selective Internal Radiation Therapy (SIR-spheres) in patients with unresectable liver metastases from colorectal cancer previously treated with 5-FU based chemotherapy

    International Nuclear Information System (INIS)

    Lim, L; Gibbs, P; Yip, D; Shapiro, JD; Dowling, R; Smith, D; Little, A; Bailey, W; Liechtenstein, M

    2005-01-01

    To prospectively evaluate the efficacy and safety of selective internal radiation (SIR) spheres in patients with inoperable liver metastases from colorectal cancer who have failed 5FU based chemotherapy. Patients were prospectively enrolled at three Australian centres. All patients had previously received 5-FU based chemotherapy for metastatic colorectal cancer. Patients were ECOG 0–2 and had liver dominant or liver only disease. Concurrent 5-FU was given at investigator discretion. Thirty patients were treated between January 2002 and March 2004. As of July 2004 the median follow-up is 18.3 months. Median patient age was 61.7 years (range 36 – 77). Twenty-nine patients are evaluable for toxicity and response. There were 10 partial responses (33%), with the median duration of response being 8.3 months (range 2–18) and median time to progression of 5.3 mths. Response rates were lower (21%) and progression free survival shorter (3.9 mths) in patients that had received all standard chemotherapy options (n = 14). No responses were seen in patients with a poor performance status (n = 3) or extrahepatic disease (n = 6). Overall treatment related toxicity was acceptable, however significant late toxicity included 4 cases of gastric ulceration. In patients with metastatic colorectal cancer that have previously received treatment with 5-FU based chemotherapy, treatment with SIR-spheres has demonstrated encouraging activity. Further studies are required to better define the subsets of patients most likely to respond

  18. Language Learners' "Willingness to Communicate" through Livemocha.com Le "désir de communiquer" d'apprenants de langue sur Livemocha.com

    Directory of Open Access Journals (Sweden)

    Elwyn Lloyd

    2012-03-01

    'indicateur de type Myers-Briggs pouvaient être prises en compte. Plusieurs études ont suggéré que l'anxiété ressentie par certains apprenants de langue quand ils doivent communiquer en L2, en particulier à l'oral, est réduite dans des environnements d'échange en ligne. Partant du principe qu'une réduction de l'anxiété peut conduire à un "désir de communiquer" accru (MacIntyre et al., 1998, le principal objectif de ce projet était d'examiner le type et la fréquence des interactions en ligne dans lesquelles les participants s'engageaient avec d'autres locuteurs de leur langue cible dans la communauté d'apprentissage des langues de Livemocha.

  19. Le rôle de l’intertexte et du palimpseste dans la création d’une Écosse mythique dans Waverley et Rob Roy de Walter Scott

    Directory of Open Access Journals (Sweden)

    Céline SABIRON

    2010-03-01

    Full Text Available L’Écosse des Lumières, récemment rattachée à sa puissante voisine anglaise par l’Acte d’Union de 1707, connaît une crise identitaire qui l’amène à une redéfinition de son image. Sa représentation, tant tangible, physique que mentale, nationale, passe par une réécriture de son Histoire par le mythe, ce récit imaginaire populaire ou littéraire mettant en scène des êtres surhumains et des actions remarquables qui est, selon Roland Barthes, « un discours, un système de communication, un message » (Mythologies. Ce message d’une re-construction identitaire est transmis par Walter Scott dans ses romans écossais, en particulier Waverley et Rob Roy qui dépeignent l’Écosse et ses habitants à travers les yeux naïfs d’érudits anglais. Ce portrait textuel, loin d’être un tableau réaliste, est brossé à l’aide d’une superposition d’images mythiques et littéraires, notamment dans la description des paysages des Highlands. De plus, les personnages, tel le héros populaire historique et hors-la-loi écossais Rob Roy, sont transformés, romancés, mythifiés dans ces fictions qui retracent, sous forme d’épopée, les grandes révoltes jacobites de 1715 et 1745. Enfin, le langage pictural et imagé contribue à véhiculer une vision mythique de l’Écosse. Nous chercherons donc à comprendre et à expliquer les motivations et les répercussions de ce maillage d’images fictives connues, tirées de mythes ou d’ouvrages littéraires, et tissées au moyen d’images rhétoriques au texte scottien pour créer nouveau visage écossais.Recently united to its powerful English twin sister through the 1707 Union Act, Scotland experiences a major identity crisis in the Enlightenment. Politically, religiously, and socially divided, it is led to redefine its image by rewriting history through mythology. A myth is “a speech, a system of communication, a message”, Roland Barthes explains in Mythologies. This message

  20. Academic Librarians Have Concerns about Their Role as Teachers. A Review of: Walter, Scott. “Librarians as Teachers: A Qualitative Inquiry into Professional Identity.” College and Research Libraries 69.1 (2008: 51-71.

    Directory of Open Access Journals (Sweden)

    Virginia Wilson

    2008-09-01

    the teaching role was valued.The role of teacher spilled over into the other roles of the librarian, i.e., reference service, collection development, etc. Thenext theme was the importance of collegial and administrative support, which is critical to the ability to focus on work as a teacher. The stress of multiple demands emerged as a theme, as time dedicated to teaching was often at the expense of something else. Another theme was the problems with professional education around teaching. Instruction course offerings in library schools were reported to be meagre, and some were badly planned and executed. The fifth theme involved stereotypes and misperceptions. Studies have shown that the academic library profession has been poorly understood by students and faculty. Study participants believed that many of their campus colleagues were either unaware of what they did, or were misinformed by popular culture stereotypes of librarians.Conclusions – The small sample size precluded the making of any definite conclusions based on the study results. Other limitations of the study include the relatively short amount of time spent in the interview process and the narrow range of librarians chosen to participate. The author notes that a subject pool more representative of academic librarians’ full range of opinions regarding the importance of teaching as a professional responsibility would have resulted in more complex themes emerging. While the author is aware of the study’s limitations, he feels there is value in the qualitative research design, in giving voice to individual librarians, and in the provision of insight into some of the research questions found in the literature of learning to teach and of teacher identity. Given the limitations, Walter makes three conclusions about his findings. He points out the lack of a formal introduction to teaching in many library programs which has been explored by other studies and concludes that his study “suggests that

  1. Solène Daoudal, Sirènes romanes en Poitou, XIe-XIIe siècles. Avatars sculptés d’une figure mythique

    Directory of Open Access Journals (Sweden)

    Didier Lett

    2009-07-01

    Full Text Available Vers 1140, dans la toute dernière lettre qu’il adresse à Héloïse, comme pour se rassurer face à « l’histoire de ses malheurs », Abélard termine par ces mots : « A l'abri de cette foi salutaire, je ne crains pas les aboiements de Scylla, je me ris des gouffres de Charybde, et j’entends sans frémir les chants des sirènes. Si la tempête éclate, je ne suis pas renversé. Si les vents grondent, je ne suis pas ému. Je suis fondé sur une pierre inébranlable ». Dans cet autoportrait du penseur scolast...

  2. Emerging Trends in Applied Mathematics: Dedicated to the Memory of Sir Asutosh Mookerjee and Contributions of S.N. Bose, M.N. Saha and N.R. Sen

    CERN Document Server

    Basu, Uma; De, Soumen

    2015-01-01

    The book is based on research presentations at the international conference, “Emerging Trends in Applied Mathematics: In the Memory of Sir Asutosh Mookerjee, S.N. Bose, M.N. Saha, and N.R. Sen”, held at the Department of Applied Mathematics, University of Calcutta, during 12–14 February 2014. It focuses on various emerging and challenging topics in the field of applied mathematics and theoretical physics. The book will be a valuable resource for postgraduate students at higher levels and researchers in applied mathematics and theoretical physics. Researchers presented a wide variety of themes in applied mathematics and theoretical physics—such as emergent periodicity in a field of chaos; Ricci flow equation and Poincare conjecture; Bose–Einstein condensation; geometry of local scale invariance and turbulence; statistical mechanics of human resource allocation: mathematical modelling of job-matching in labour markets; contact problem in elasticity; the Saha equation; computational fluid dynamics with...

  3. 12 December 2013 - Sir Konstantin Novoselov, Nobel Prize in Physics 2010, signing the guest book with International Relations Adviser E. Tsesmelis; visiting the ATLAS experimental cavern with Spokesperson D. Charlton; in the LHC tunnel with Technology Department Head F. Bordry. I. Antoniadis, CERN Theory Group Leader, accompanies throughout.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    12 December 2013 - Sir Konstantin Novoselov, Nobel Prize in Physics 2010, signing the guest book with International Relations Adviser E. Tsesmelis; visiting the ATLAS experimental cavern with Spokesperson D. Charlton; in the LHC tunnel with Technology Department Head F. Bordry. I. Antoniadis, CERN Theory Group Leader, accompanies throughout.

  4. The Walter Reed performance assessment battery.

    Science.gov (United States)

    Thorne, D R; Genser, S G; Sing, H C; Hegge, F W

    1985-01-01

    This paper describes technical details of a computerized psychological test battery designed for examining the effects of various state-variables on a representative sample of normal psychomotor, perceptual and cognitive tasks. The duration, number and type of tasks can be customized to different experimental needs, and then administered and analyzed automatically, at intervals as short as one hour. The battery can be run on either the Apple-II family of computers or on machines compatible with the IBM-PC.

  5. The essayistic style of Walter Benjamin

    OpenAIRE

    Ceserani, Remo

    2015-01-01

    Članek obravnava tipični esejistični stil Walterja Benjamina. Za vse žanre njegovega pisanja je značilna alegoričnost in surrealističnost s skritimi ter zasebnimi (in esejističnimi) pomeni, a tudi s preroško halucinatorično napetostjo.

  6. Attache Extraordinaire: Vernon A. Walters and Brazil

    Science.gov (United States)

    2009-03-01

    Intelligence College (NDIC), instituição de ensino ligada ao Defense Intelligence Agency (DIA), que, dentre outras atribuições, coordena o sistema ...personagem central de eventos. Ele soube aproveitar as singulares oportunidades surgidas com a Segunda Guerra e com o sistema ideológico que ela engendrou...inteligência. Ele foi um soldado-diplomata, nas palavras de Roberto Campos,7 operando no campo de batalha invisível da 4 Gladwell desenvolve uma teoria em

  7. Alvarez, Luis Walter (1911-88)

    Science.gov (United States)

    Murdin, P.

    2000-11-01

    Physicist and astronomer, born in San Francisco, CA, professor at the University of California, Nobel prizewinner (1968) for his discoveries in particle physics. Used cosmic rays to `x-ray' the pyramids of Egypt, finding in particular that the tombs in the Great Pyramid at Giza had no hidden rooms. Alvarez (and his son) discovered globally distributed iridium at the Cretaceous/Tertiary boundary i...

  8. Paterson Receives 2004 Walter H. Bucher Medal

    Science.gov (United States)

    Jackson, Ian

    2005-01-01

    Mervyn S. Paterson received the Bucher Medal at the 2004 Fall Meeting Honors Ceremony on 15 December, in San Francisco, California. The medal is given for original contributions to the basic knowledge of the crust and lithosphere. Citation. It is the nature of modern research in the Earth sciences that observations of natural phenomena are often made and interpreted through the prism provided by the enabling sciences and technologies. Thus it has been with Mervyn Paterson's career. His undergraduate training in engineering in Adelaide formed the basis for his Ph.D. study of X-ray line-broadening in cold-worked metals under Orowan at Cambridge. This interest in the deformation of metals was fostered during his employment at the Aeronautical Research Laboratories in Melbourne and by postdoctoral experience at the Institute of Metals at the University of Chicago. Mervyn's general background in engineering and his particular interest in mechanical behavior have underpinned a distinguished career at the Australian National University in the experimental deformation of rocks, providing fundamental new insight into the mechanical behavior of the Earth's crust.

  9. ‘Global’ Identity or the (IrReducible Other: The Cultural Logic of Global Identity in Sir Arthur Conan Doyle’s The Man with the Twisted Lip

    Directory of Open Access Journals (Sweden)

    Lee Jin

    2016-12-01

    Full Text Available After the Syrian civil war, deaths of those fleeing crisis areas have tragically become a regular news item. Not new to the world, however, such crises emerge from tensions between identity and difference as codified in international politics, whereby refugees and migrants become the Other and subject to unyielding universals, such as the law or narrow concepts of what is right. Indeed, the cultural logic of “global identities” informing the current refugee and migrant crisis seems recurrent, as exemplified in the recent cases of the Tamils from Sri Lanka and the Somalis. The cultural logic of global identity is also reflected in the popular nineteenth-century novella by Sir Arthur Conan Doyle, The Man with the Twisted Lip, in which the main character disguises himself as a professional beggar to appeal to middle class values in order to incite their guilty consciences. Drawing on Ian Baucom, Marc Shell, and Jean-Joseph Goux, this article argues that the main character’s actions reflect and embody the cultural logic of the global politico-economy in late nineteenth century London. As such, Doyle’s novella illustrates the Derridean notion of hospitality by revealing that “identity and difference are mutually constitutive” (Baker 109 and offers insightful commentary on the current refugee and migrant crisis.

  10. Integration of a complex regulatory cascade involving the SirA/BarA and Csr global regulatory systems that controls expression of the Salmonella SPI-1 and SPI-2 virulence regulons through HilD.

    Science.gov (United States)

    Martínez, Luary C; Yakhnin, Helen; Camacho, Martha I; Georgellis, Dimitris; Babitzke, Paul; Puente, José L; Bustamante, Víctor H

    2011-06-01

    Salmonella pathogenicity islands 1 and 2 (SPI-1 and SPI-2) play key roles in the pathogenesis of Salmonella enterica. Previously, we showed that when Salmonella grows in Luria-Bertani medium, HilD, encoded in SPI-1, first induces the expression of hilA, located in SPI-1, and subsequently of the ssrAB operon, located in SPI-2. These genes code for HilA and the SsrA/B two-component system, the positive regulators of the SPI-1 and SPI-2 regulons respectively. In this study, we demonstrate that CsrA, a global regulatory RNA binding protein, post-transcriptionally regulates hilD expression by directly binding near the Shine-Dalgarno and translation initiation codon sequences of the hilD mRNA, preventing its translation and leading to its accelerated turnover. Negative regulation is counteracted by the global SirA/BarA two-component system, which directly activates the expression of CsrB and CsrC, two non-coding regulatory RNAs that sequester CsrA, thereby preventing it from binding to its target mRNAs. Our results illustrate the integration of global and specific regulators into a multifactorial regulatory cascade controlling the expression of virulence genes acquired by horizontal transfer events. © 2011 Blackwell Publishing Ltd.

  11. The Effect of Size and Crumb Rubber Composition as a Filler with Compatibilizer Pp-G-Ma in Polypropylene Blends and Sir-20 Compound on Mechanical and Thermal Properties

    Directory of Open Access Journals (Sweden)

    Erna Frida

    2013-04-01

    Full Text Available Having been researched the development of thermoplastic elastomer material of polypropylene and natural rubber SIR-20 compound with Crumb Rubber as the filler. Reinforced polypropylene with size 60 mesh with 1 mm, and the composition of the Crumb rubber (30, 40, and 50 wt%. Observed mechanical properties are tensile strength, fracture elongation, Young's modulus, tear strength and impact strength. Thermal properties are analyzed by DSC and DTA/TGA. It is acquired that for the size of 60 mesh crumb rubber tensile strength, fracture elongation, Young’s modulus, tear strength and impact strength are bigger than 1mm size. The addition of 60 mesh crumb rubber increases but it decreases by adding of 50 weight%. While for crumb rubber 1 mm tensile strength, fracture elongation, tear strength and impact strength decreas. Based on analysis of DSC that the addition of crumb rubber does not make a difference boiling point significantly between samples containing crumb rubber and polypropylene Analysis TGA/DTA to an increase in enthalpy and decomposition temperature with the addition of crumb rubber used and thermal stability.

  12. Te’sîr-İ Tebrîzî’nin Külliyatı Ve Türkçe Şiirleri Te’sir-i Tebrizi’s Treatise And His Turkish Poems

    Directory of Open Access Journals (Sweden)

    Mehmet Nuri ÇINARCI

    2012-12-01

    Full Text Available Within its historical development, one of the most prolific regions of Turkish Literature is Iran that was governed almost one thousand year by Turkish dynasties. Although Iran was governed by Turkish dynasties, in view of its history and literary culture, Iran is the centre of works written in Persian language. Though a great number of poets, grown particularly during the reign of Akkoyunlu, Safavids, Avsars, Kacars, composed their poems in Persian language; they also reserved Turkish poems in their anthologies (Divan either in a limited number or composed poems as many as that could form a separate anthology in its own right. The tradition of composing poem in Turkish was not only peculiar to poets but it was also fulfilled by the Ruler and those who belonged to his family. Cihan Shah, the Ruler of Karakoyunlu, came first with the pen name of Hakiki, Shah Ismail writing under the penname of Hatayi, Shah Abbas II whose pen name was Sani and IbrahimMirza who composed his poems under the pen name of Cahi are all inthe position of the followers of this tradition. Furthermore, Turkishpoems are included in a small amount in the divans of Vaiz-i Kazvi andin an amount enough to compose a small divan in the divans of Saib-iTebrizi, both of whom are among the prominent figures of Sebk-i Hindimovement. Te’sir Tebrizi is also one of the poets with a treatise, havinglived in the Safavids’ era and written Turkish kasides for ShahSüleyman the First and for Shah Huseyin. In this study, ouressential aim is to both present information about the life and treatiseof Te’sir Tebrizi and to discuss his Turkish poems written in variousverses. Türk edebiyatının tarihi gelişim süreci içerisinde en çok eser verdiği bölgelerden biri de yaklaşık bin yıl boyunca Türk hanedanları tarafından yönetilen İran’dır. İran’ın tarihsel geçmişi ve edebi kültürü göz önünde bulundurulduğu zaman her ne kadar Türk hanedanlar tarafından y

  13. The Cape and Sir Henry Marshall

    African Journals Online (AJOL)

    expand throughout his professional life, namely a wholly new concept of the ... happiness and ultimate degradation of the common soldier serving on garrison .... longer than older soldiers, however much seasoned by residence or disease.

  14. NDJIGUI Paul-Dйsirй

    African Journals Online (AJOL)

    ginous and very hardened nature that offer rйsistance to the 'leaching process activated by Water ...... ((2002) document that several metals like Ni, Cr, Pd, Pt are in the structures of' ..... Nahon D., (2000) Early Weatheriiag of palladium gold.

  15. Fisher, Sir Ronald Aylmer (1890-1962)

    Science.gov (United States)

    Murdin, P.

    2000-11-01

    Statistician, born in London, England. After studying astronomy using AIRY's manual on the Theory of Errors he became interested in statistics, and laid the foundation of randomization in experimental design, the analysis of variance and the use of data in estimating the properties of the parent population from which it was drawn. Invented the maximum likelihood method for estimating from random ...

  16. Chemical Research of Sir Prafulla Chandra Ray

    Indian Academy of Sciences (India)

    Calcutta University as the first Palit Professor of Chemistry in the year 1916 ... He and his students prepared ... Indian Chemical Society was born) were published in the Journal .... to develop the chemistry of alkylammonium nitrites. He pre-.

  17. Sir Bob Edwards: Salute to a Giant

    Indian Academy of Sciences (India)

    ... annual meeting of the European Society of Human Reproduction and Embryology ... 1960s trying to explain the maturation of oocytes in the in vitro mouse model. In ... Scientific and Managing Director, London Women's Clinic, Harley Street, ...

  18. Autobiography of Sir George Biddell Airy

    Science.gov (United States)

    Airy, George Biddell; Airy, Wilfred

    2010-06-01

    Preface; 1. Personal sketch of George Biddell Airy; 2. From his birth to his taking his B.A. degree; 3. At Trinity College, Cambridge; 4. At Cambridge Observatory; 5. At Greenwich Observatory, 1836-1846; 6. At Greenwich Observatory, 1846-1856; 7. At Greenwich Observatory, 1856-1866; 8. At Greenwich Observatory, 1866-1876; 9. At Greenwich Observatory to his resignation in 1881; 10. At the White House, Greewich, to his death; Appendix: List of printed papers; Index.

  19. Sir Charles Scott Sherrington (1857–1952)

    Indian Academy of Sciences (India)

    IAS Admin

    Sherrington had the genius to see the real need to amalgamate the scattered ideas in neurophysiology at that time, to give a compre- hensive overview that changed our ... and desire for travel were all because of him. Despite Sherrington's.

  20. Study of vitamin D status of rheumatoid arthritis patients Rationale and design of a cross-sectional study by the osteoporosis and metabolic bone diseases study group of the Italian Society of Rheumatology (SIR

    Directory of Open Access Journals (Sweden)

    M. Antonelli

    2011-09-01

    Full Text Available The fundamental role of Vitamin D has been long known in regulating calcium homeostasis and bone metabolism. An increased contribution of Vitamin D was recently described in association with a lower incidence of Rheumatoid Arthritis (RA. This must not be surprising, as the immunomodulating effects of Vitamin D are clear, which have been attributed protective effects in autoimmune disorders such as some chronic inflammatory bowel diseases, multiple sclerosis and type I diabetes. An interaction was suggested between Vitamin D metabolism and inflammation indexes through mediation of TNF-a which is also especially involved in osteoclastic resorption and therefore in bone loss processes. Some preliminary data would indicate an association between seasonal changes of Vitamin D serum levels, latitude and disease activity (DAS28 in RA patients. Consequently, the Osteoporosis and Metabolic Bone Diseases Study Group of SIR believes that there are grounded reasons for assessing the Vitamin D status of RA patients in order to investigate whether this is to be related to physiopathological and clinical aspects of disease other than those of bone involvement. Primary end point of the study will be to assess the levels of 25 OH Vitamin D in RA patients. Secondary endpoints will include correlation with disease activity, densitometry values and bone turnover. The cross-sectional study will enrol patients of both sex genders, age ranging between 30 and 75 years according to the 1988 ACR criteria, onset of symptoms at least 2 years prior to study enrollment. Patients will be excluded suffering from osteometabolic diseases, liver and kidney insufficiency and those administered Vitamin D boli in the previous 12 months. Disease activity will be evaluated with the HAQ. Haematochemical tests and femoral and lumbar bone densitometry will be performed, unless recently undergone by patients. Blood levels of 25 OH C Vitamin D and PHT and of the two bone remodeling markers

  1. Pictures of Childhood: a close study of Sir Joshua Reynolds`s The Strawberry Girl, including a selection of his paintings of children, read in light of his The Discourses on Art and Jean-Jacques Rousseau`s Emile, or On Education.

    OpenAIRE

    Nordby, Oda Nygaard

    2015-01-01

    Pictures of Childhood is a study of Sir Joshua Reynolds s paintings of children in light of Reynolds s The Discourses on Art, 1769-1790, and Jean-Jacques Rousseau s Emile, or On Education, 1762. A close reading of The Discourses on Art reveals that Reynolds thought art should seek a general truth, and that art should make an impression on the beholder s imagination and feeling. In Emile, Rousseau abandons original sin. This led to a perception of childhood as a happy and content phase of life...

  2. Protocolo de manejo de suspeita de infecção viral de vias respiratórias em pacientes com neoplasia hematológica do serviço de hematologia e transplante de medula óssea do Hospital Universitário Walter Cantídio (HUWC

    Directory of Open Access Journals (Sweden)

    Élida Lívia Rafael Dantas

    2015-06-01

    Full Text Available Infecção respiratória viral é causa significativa de morbi-mortalidade em paciente com doenças hematológicas. Deve ser suspeitado sempre que houver sintomas como coriza, obstrução nasal, odinofagia, tosse e dispnéia e deve-se seguir à identificação viral, quando possível. Os casos podem ser classificados como possível, provável ou confirmado. E observando-se o risco de progressão da infecção para vias aéreas inferiores, o diagnóstico deve ser precoce e as medidas terapêuticas específicas aos vírus bem como medidas de controle da infecção no ambiente hospitalar devem ser prontamente tomadas. O presente trabalho visa descrever um protocolo de manejo da infecção viral de vias respiratórias em pacientes com neoplasia hematológica dentro do Serviço de Hematologia e Transplante de medula do Hospital Universitário Walter Cantídio.

  3. Description of a cohort of patients with criteria of systemic inflammatory response syndrome (SIRS in two third-level hospitals Descripción de una cohorte de pacientes con criterios de síndrome de respuesta inflamatoria sistémica en dos hospitales de tercer nivel

    Directory of Open Access Journals (Sweden)

    Fabián Alberto Jaimes Barragán

    2001-01-01

    Full Text Available Introduction: The Systemic Inflammatory Response Syndrome (SIRS, sepsis and their complications have been considered as an important cause of consult and admission at emergency third-level centers. In our region, many aspects related with epidemiology, clinical presentation and microbiology of this illness are still not defined. Type of study: Longitudinal cohort study. Population: Hospitalized patients who entered through emergency services at reference hospitals, with non-traumatic community-acquired SIRS criteria, between August 1, 1998 and March 31, 1999. Methods: Recollection of clinical, epidemiological and microbiological information on patients with SIRS criteria at admission to emergency services. Results: 503 patients were admitted to the study; age range was between 14 and 97 years, mean 49 years. 46.5% were women, 27.8% were housekeeping women, 12.7% unemployed and 4.9% farmers. Average time of hospitalization was 11.7 days. The main diagnoses at admission were pneumonia, sepsis and soft tissue infections. Staphylococcus aureus, Streptococcus pneumoniae and Escherichia coli were the most commonly isolated bacteria on blood cultures. Shock (17.2% and adult respiratory distress syndrome (13.1% were the most common complications. In 58.8% of patients with clinical infectious SIRS, blood cultures were negative; pneumonia and soft tissue infection were the most common diagnoses in this group. Conclusion: SIRS and sepsis are common entities in our hospitals. The population of study is heterogeneous in epidemiological, microbiological and age aspects, compared with other regions where it is older and remain hospitalized for longer periods. Although patients with SIRS have clinically an infectious origin, in an important number of them, blood cultures are negative. Main diagnoses of patients with SIRS at admission and the microorganisms isolated from them were similar in our study to those reported in the literature. Se ha considerado al s

  4. 03 Wessels 03.pmd

    African Journals Online (AJOL)

    Tienie01

    12 Jun 2006 ... benadering definieer. Maria Edgeworth (1767-1849) het byvoorbeeld na 'n realistiese uitbeelding van haar samelewing gestreef en word as 'n belangrike invloed op beide Sir Walter Scott se historiese werke en Jane Austen se sosiale romans beskou. (Albei skrywers het haar bewonder en. 03 Wessels 03.

  5. ENGLISH, JUNIOR YEAR, SECOND SEMESTER. HIGH SCHOOL TELEVISION SERIES, SEMINAR--63.

    Science.gov (United States)

    GANCZEWSKI, JOAN D.

    NINETY TELECAST OUTLINES ARE INCLUDED. THE CLASS WAS BROADCASTED FIVE MORNINGS A WEEK FOR 18 WEEKS. THE TELECAST BEGAN WITH THE ROMANTIC PERIOD, INCLUDING ROBERT BURNS, ROBERT LOUIS STEVENSON, THE LAKE POETS, SIR WALTER SCOTT, LAMB, HAZLITT, LORD BYRON, P.B. SHELLEY, JOHN KEATS, AND JANE AUSTEN. LESSONS ON GRAMMAR, SPELLING, AND THE FIRST…

  6. The Military and Society. Proceedings of the Military History Symposium (5th), United States Air Force Academy, 5-6 October 1972,

    Science.gov (United States)

    1972-01-01

    V, 305-7 The speed and telescoping nature of modernizing process in ISutfliYa. XII. I Ogawa GotarO. inter aba Japan. =5Ohtani. p. 16; M U The early...Ronald. Lieutenant. USMC. lege. Cambridge. v 66 l6iba. 20. 22. 24. 27 Millis, Walter, i 163 n, Vice Admiral, l.iddell Hart, Captain Sir Basil H

  7. Heinrich Schenker, Walter Dahms, and the Music of the South

    NARCIS (Netherlands)

    Koslovsky, John

    2017-01-01

    In recent years scholars have made great strides in contextualizing the theories of Heinrich Schenker (18681935) within the politics and culture of the interwar period. Many of Schenker’s closest pupils and disciples have now also come under investigation. Few present as bewildering a story as

  8. TÜ vilistlane ja polaaruurija Herman Walter / Erki Tammiksaar

    Index Scriptorium Estoniae

    Tammiksaar, Erki, 1969-

    2011-01-01

    Eduard Gustav von Tolli poolt juhitud polaarekspeditsioonil 1901. aastal surnud ja Kotelnõi saarele maetud arsti Herman Walteri säilmete ümbermatmisest ning tema isiklike esemete annetamisest Tartu Ülikooli Ajaloomuuseumile

  9. Walter Schmithals: His contribution to the theological and historical ...

    African Journals Online (AJOL)

    Test

    2010-07-10

    Jul 10, 2010 ... A serious need exists amongst students and other persons for a pointer in .... bridge the gap in time, the past reality must become real again. The potential for ...... but the superpowers arm themselves to survive. Peace in the.

  10. O olho e a mão: Walter Gropius

    OpenAIRE

    Rodrigo Mendes de Souza

    2014-01-01

    Os estatutos, programas, disciplinas e exercícios dos alunos do curso preliminar da Bauhaus Vorkurs sob diretoria de W. Gropius são analisados neste trabalho a partir das teorias da Puravisualidade Sichtbarkeit e da Objetividade Sachlichkeit. Autores como K. Fiedler, A. Riegl, H. Wölfflin, entre outros, estabelecem as divisas da primeira corrente estética. A segunda, expressa por G. Semper, é usualmente associada à Bauhaus devido à sua abordagem da função. O objetivo é mostrar que, para uma c...

  11. [Walter Matthias Diggelmann--the healing effect of story telling].

    Science.gov (United States)

    Schmid, H J

    2001-06-21

    "Stories are weapons against disease" wrote Swiss writer WM Diggelmann (1927-1979). In writing stories he hoped to counteract the lethal course of his cancer. In the past it had helped him to overcome destitution and social disgrace and had given him identity. His last story Walking on the Island of St. Margaret is a ritual which conjures up an intact future by celebrating the past. Stories try to explain the world. They inform or clarify emotions. In telling stories, doctors and nurses demonstrate sympathy and understanding. Perhaps even greater benefits might be derived from patients telling their own stories. In doing so they emerge as individuals and give their lives purpose. Language is more than communication: it is shelter, link, home, ritual. Storytelling helps patients cope with their diseases. It is not clear whether this or any technique of psychotherapy has any effect upon the course of cancer.

  12. Double-diffusive convection of compressible rotating Walters' (B ...

    African Journals Online (AJOL)

    user

    Mathematical Formulation of the Problem and Perturbation Equations ...... Rayleigh number for the onset of instability via a state of pure oscillations, it suffices to find conditions for which ..... Cambridge University Press, Cambridge, UK.

  13. Walter Sutton and the Chromosome Theory of Heredity

    Indian Academy of Sciences (India)

    Admin

    and played basketball, a young sport hardly ten-years-old started by D r. Jam es N ... course ofthese studies that Sutton m ade the im portant connection betw een ... his tw o sem inalpapers in 1902 and 1903 in the journal B iological B ulletin.

  14. Spine Research at Walter Reed Army Medical Center

    National Research Council Canada - National Science Library

    Kuklo, Timothy

    2004-01-01

    .... This can often result in spinal trauma as a cause of back pain and back problems. Treatment of these spinal injuries may allow for return to duty of some of these soldiers when treated in an optimal fashion...

  15. Der Internationale Menschenrechtsschutz zwischen Konstitutionalisierung und Fragmentierung / Christian Walter

    Index Scriptorium Estoniae

    Walter, Christian

    2015-01-01

    Inimõiguste rahvusvahelisest kaitsest; inimõiguste ja põhivabaduste kaitse konventsioonist ning Euroopa Inimõiguste Kohtu praktikast riigisisese õiguse aspektist; Liidu Halduskohtu avalike teenistujate streigikeelu lahendist (27.02.2014)

  16. Solutions of the SIR models of epidemics using HAM

    International Nuclear Information System (INIS)

    Awawdeh, Fadi; Adawi, A.; Mustafa, Z.

    2009-01-01

    In this paper, we investigate the accuracy of the Homotopy Analysis Method (HAM) for solving the problem of the spread of a non-fatal disease in a population. The advantage of this method is that it provides a direct scheme for solving the problem, i.e., without the need for linearization, perturbation, massive computation and any transformation. Mathematical modeling of the problem leads to a system of nonlinear ODEs. MATLAB 7 is used to carry out the computations. Graphical results are presented and discussed quantitatively to illustrate the solution.

  17. Sir Hugh Cairns: The neurosurgeon who introduced crash helmets

    Directory of Open Access Journals (Sweden)

    Shahsivadhanan Sundaravadhanan

    2017-01-01

    Full Text Available Statistics prove that more Indians die in Road traffic related accidents than in wars. Prior to World War II, the death toll across the world used to be very high. It was at this juncture that a Military Neurosurgeon named Hugh Cairns introduced the compulsory wearing of crash helmets and brought about a reduction in mortality by more than 50%. Within a decade of introduction of crash helmets in Britain, the entire world followed suit. The results of his efforts are here for all of us to see. This innovative military neurosurgeon is credited as the one who introduced the concept of mobile neurosurgical units during world war and also the first proponent of usage of penicillin in war. His concepts in war surgery are still followed by militaries across the world. This article comes as a tribute to this great Neurosurgeon who helped in saving millions of lives.

  18. Sir Galahad, skiing and a woman's quest for freedom

    DEFF Research Database (Denmark)

    Pfister, Gertrud Ursula

    2013-01-01

    in winter. She also learned ski jumping. The little information that is available about her skiing activities clearly demonstrates that this sport played a key role in her life. Besides perfectly keeping up with her self-image as a competent woman, skiing provided her with the opportunity of escaping normal...

  19. Understanding Leadership Theory: The Documentary of Sir Ernest Shackleton

    Science.gov (United States)

    Cheramie, Robin A.

    2015-01-01

    Leadership theory is one of the most complex groups of theories to teach management students; nevertheless, it is the one of the most interesting and often desired topics to learn from students. Many organizations are seeking soft skills that are commonly discussed in leadership theory such as building relationships with followers, taking…

  20. Judaism in the theology of Sir Isaac Newton

    CERN Document Server

    Goldish, Matt

    1998-01-01

    This book is based on my doctoral dissertation from the Hebrew University of Jerusalem (1996) of the same title. As a master's student, working on an entirely different project, I was well aware that many of Newton's theological manuscripts were located in our own Jewish National and University Library, but I was under the mistaken assumption that scores of highly qualified scholars must be assiduously scouring them and publishing their results. It never occurred to me to look at them at all until, having fmished my master's, I spoke to Professor David Katz at Tel-Aviv University about an idea I had for doctoral research. Professor Katz informed me that the project I had suggested was one which he himself had just fmished, but that I might be interested in working on the famous Newton manuscripts in the context of a project being organized by him, Richard Popkin, James Force, and the late Betty Jo Teeter Dobbs, to study and publish Newton's theological material. I asked him whether he was not sending me into ...

  1. prevalence of malarial parasites in pregnant women attending sir

    African Journals Online (AJOL)

    DR. AMINU

    Keyword: Prevalence, Malarial Parasite, Pregnant Women, Kano. INTRODUCTION ... protective semi-immunity against plasmodium falciparum is acquired during the first 10-. 15 years of life and .... hiding place for the mosquito? It is therefore ...

  2. [Sir William Richard Gowers: author of the "bible of neurology"].

    Science.gov (United States)

    Hirose, Genjiro

    2014-11-01

    William Richard Gowers is one of the great pioneers in neurology and the author of the well-known neurology textbook, "A Manual of Diseases of the Nervous System." His concepts of neurology are based on meticulously and carefully accumulated knowledge of history, observations, and neurological examinations of patients with various neurological diseases. He is not only a great neurologist but also a great teacher who loves teaching students and physicians through well-prepared lectures. We can glean the essence of the field of neurology through his life story and numerous writings concerning neurological diseases.

  3. Sir William Petty: modern epidemiologist (1623-1687).

    Science.gov (United States)

    Banta, J E

    1987-01-01

    William Petty, physician, epidemiologist, political economist, demographer, cartographer, and administrator was an intellectual product of the seventeenth century. Petty was born in the year 1623 in Romsey, England of lower middle class parents; however, by the time of his death in 1687 he had become a knight of the realm, founder of the Royal Society, and friend of kings. Petty's life reflected the northern renaissance which induced such dramatic changes in science, technology, politics, and entrepreneurship. His education was eclectic, nonetheless he took his Doctor of Physic degree from Oxford in 1649 and became an Oxford don, where he spent the next few years as an academic before undertaking a definitive survey of Ireland on behalf of the Cromwell government. Ireland changed Petty's destiny and he became a man of the world and entrepreneur which stimulated his interest in public policy formulation and economics. It was Petty's peculiar genius to be innovative in the application of measurement, statistics, and mathematics to socioeconomic and demographic phenomena. As a physician he related his knowledge of health and disease to these phenomena in what in the modern context would be called human ecology or social epidemiology. These relationships and their measurement were employed to establish an objective set of data which could be analyzed for the purpose of rational public policy planning by the state. This scientific approach to public policy places Petty squarely in the context of modern epidemiologic and public health practice and marks the initiation of a major use of the epidemiologic method.

  4. Sir Mokshagundam Visvesvaraya–A Visionary Engineer par ...

    Indian Academy of Sciences (India)

    ing a social purpose. He was also ... public works engineer in March 1884 with the. Government of ... An opportunity to demonstrate his innovative abilities ... Another innovation which was .... Science - its highest policy making body - till. 1947.

  5. Status report on SIRS: sorption information retrieval system

    International Nuclear Information System (INIS)

    Hostetler, D.D.; Serne, R.J.; Baldwin, A.J.; Petrie, G.M.

    1980-11-01

    Two major uses were identified for the Sorption Information Retrieval System: (1) to aid geochemists in the elucidation of sorption mechanisms; and (2) to aid safety assessment modelers in selection of Kds for any given scenerio. Other benefits such as providing an auditable vehicle for the Kd selection were also discussed

  6. Sir Alfred Bray Kempe – An Amateur Kinematician

    Indian Academy of Sciences (India)

    sriranga

    vited talk delivered in 'The Work- shop on ... He was a true amateur academic, whom E T Bell1 called the ... of Snell's law for refraction of light ultimately proved to be correct. Though he was ... respected literary magazine of that era in Bengal.

  7. Deletion of Dictyostelium discoideum Sir2A impairs cell proliferation ...

    Indian Academy of Sciences (India)

    Rakhee Lohia

    2018-04-13

    Apr 13, 2018 ... Multicellular structures developed were collected, fixed and stained with X-gal as ... classification for Sirtuins (Fyre 2000), the above were clas- ... RNA, protein and lipid substrates (Klug 1999; Hall 2005;. Gamsjaeger et al.

  8. Crystal clear the autobiographies of Sir Lawrence and Lady Bragg

    CERN Document Server

    Thomson, Patience

    2015-01-01

    The main body of this book contains the hitherto unpublished autobiographies of both William Lawrence Bragg, an innovative scientist who won the Nobel Prize for Physics in 1915, and his wife, Alice, a Mayor of Cambridge and National Chairman of Marriage Guidance. Their autobiographies give unusual insights into the lives and times of two distinguished people and the real personalities behind their public appearance.

  9. Sir Francis Galton e os extremos superiores da curva normal

    Directory of Open Access Journals (Sweden)

    Geraldo Salgado-Neto

    2011-01-01

    a teoria do anticiclone e redescobriu as impressões digitais, criando o primeiro sistema de identificação pessoal, foi um dos fundadores da antropologia, mas foi com o conceito da Eugenia, sua maior contribuição que sua figura foi mundialmente reconhecida.

  10. Virgin esitleb : Robin Hood ja sir Branson / Mart Raudsaar

    Index Scriptorium Estoniae

    Raudsaar, Mart, 1973-

    2003-01-01

    Ettevõtja Richard Branson'i elust, karjäärist, juhtimisprintsiipidest ning tegevusest kaubamärgi Virgin loomisel, mis ühendab endas kaht lennufirmat, reisibürood, margiviina, koolat, muusikakaubamajasid, pensionifonde jne. Lisa: Branson - koolist väljalangenud miljardär

  11. Sir David Brewster's changing ideas on the plurality of worlds

    Science.gov (United States)

    de Asúa, Miguel

    2006-06-01

    In the course of his long life the Scottish physicist David Brewster wrote copiously about the plurality of worlds. More Worlds than One (1854), perhaps his strongest statement on the question, was written as an answer to William Whewell's On the Plurality of Worlds (1853), which argued that life was a privilege of the Earth. Brewster's ideas changed drastically along the years in many crucial issues such as the habitability of the Sun and the Moon, the possibility that extraterrestrials could be different from humans, and the occupation of the Earth by intelligent races in the distant past. This paper succinctly surveys Brewster's main lines of thought about the plurality of worlds underlining the significance of his first two articles devoted exclusively to this topic. They were published in 1838 in The Monthly Chronicle, and affirm the habitability of the planets while denying that of the Moon. As is the case with many Victorian scientists, belief in pluralism was for Brewster part and parcel of a complex of ideas and attitudes in which it is hard to distinguish science from religion. I shall argue that a fair number of the shifting opinions and inconsistencies detectable in Brewster's ideas on the plurality of worlds can be attributed to the fact that these were used as pliable apologetic instruments in his scientific writings, many of which are permeated by strong religious concerns.

  12. Steady States in SIRS Epidemical Model of Mobile Individuals

    International Nuclear Information System (INIS)

    Zhang Duanming; He Minhua; Yu Xiaoling; Pan Guijun; Sun Hongzhang; Su Xiangying; Sun Fan; Yin Yanping; Li Rui; Liu Dan

    2006-01-01

    We consider an epidemical model within socially interacting mobile individuals to study the behaviors of steady states of epidemic propagation in 2D networks. Using mean-field approximation and large scale simulations, we recover the usual epidemic behavior with critical thresholds δ c and p c below which infectious disease dies out. For the population density δ far above δ c , it is found that there is linear relationship between contact rate λ and the population density δ in the main. At the same time, the result obtained from mean-field approximation is compared with our numerical result, and it is found that these two results are similar by and large but not completely the same.

  13. Steady States in SIRS Epidemical Model of Mobile Individuals

    Institute of Scientific and Technical Information of China (English)

    ZHANG Duan-Ming; LIU Dan; HE Min-Hua; YU Xiao-Ling; PAN Gui-Jun; SUN Hong-Zhang; SU Xiang-Ying; SUN Fan; YIN Yan-Ping; LI Rui

    2006-01-01

    We consider an epidemical model within socially interacting mobile individuals to study the behaviors of steady statesof epidemic propagation in 2D networks. Using mean-field approximation and large scale simulations, we recover the usual epidemic behavior with critical thresholds δc and pc below which infectious disease dies out. For the population density δ far above δc, it is found that there is linear relationship between contact rate λ and the population density δ in the main. At the same time, the result obtained from mean-field approximation is compared with our numerical result, and it is found that these two results are similar by and large but not completely the same.

  14. Interview with Abel Laureate Sir Andrew J. Wiles

    DEFF Research Database (Denmark)

    Raussen, Martin Hubert; Skau, Christian

    2017-01-01

    Andrew J. Wiles is the recipient of the 2016 Abel Prize of the Norwegian Academy of Science and Letters. The interview was conducted by Martin Raussen And Christian Skau in Oslo on May 23, 2016, in conjunction with the Abel Prize celebration.......Andrew J. Wiles is the recipient of the 2016 Abel Prize of the Norwegian Academy of Science and Letters. The interview was conducted by Martin Raussen And Christian Skau in Oslo on May 23, 2016, in conjunction with the Abel Prize celebration....

  15. Proled ja poeedid / Kristel Kiigemägi, Sirli Ojaste

    Index Scriptorium Estoniae

    Kiigemägi, Kristel

    2003-01-01

    Arvustus: Verrev, Toomas. Margot : [jutustus]. Tallinn : Kadikas, 2003 ; Keil, Andres. 151 914 tähemärki. Tallinn : Hotger, 2003. Vastukaja: Kiis, Margus. Ausa kriitika (olematust) võimalikkusest väikeses ühiskonnas // Sirp (2003) 7. nov., lk. 7

  16. Sir William Henry Perkin: The Man and his 'Mauve'

    Indian Academy of Sciences (India)

    design was different. Just before he .... leaving the Royal College of Chemistry to take up manufacturing, as it was ... For Perkin, the situation to start an industry to manufacture .... Alizarin, in the early years of its production, had become a.

  17. SIR dynamics in structured populations with heterogeneous connectivity

    OpenAIRE

    Volz, Erik

    2005-01-01

    Most epidemic models assume equal mixing among members of a population. An alternative approach is to model a population as random network in which individuals may have heterogeneous connectivity. This paper builds on previous research by describing the exact dynamical behavior of epidemics as they occur in random networks. A system of nonlinear differential equations is presented which describes the behavior of epidemics spreading through random networks with arbitrary degree distributions. ...

  18. Sir Mokshagundam Visvesvaraya–A Visionary Engineer par ...

    Indian Academy of Sciences (India)

    Sciences) at Hebbal, now a suburb ofBangalore. He was convinced of the need for high quality technician education and established, using his personal resources, the Jayachamarajendra. Wodeyar Polytechnic ,at Bangalore. He also presided over the court of Indian Institute of. Science - its highest policy making body - till.

  19. Les sirènes de Copenhague !

    Directory of Open Access Journals (Sweden)

    Martine Tabeaud

    2010-01-01

    Full Text Available La Convention Cadre des Nations Unies sur le Changement Climatique (CCNUCC instance de politique internationale créée à Rio de Janeiro en 1992 a défini les moyens de lutte contre le changement climatique. Le choix s'est porté sur la réduction du réchauffement futur par la baisse des émissions de gaz à effet de serre, d'où le Protocole de Kyoto. Fin 2009, la réunion de Copenhague chargée de penser l'après Kyoto, l'après 2012 a donc polarisé à tort les plus grandes espérances quant à la refondation d'une gouvernance mondiale.

  20. Sir RA Fisher and the Evolution of Genetics

    Indian Academy of Sciences (India)

    quantitative genetics, a body of work that provides the conceptual underpinnings ... worked extensively with mutations that had large effects on structural ... altering the genetic composition of populations during adaptive ... exercise in ' writing.