SirT1 regulates energy metabolism and response to caloric restriction in mice.

Directory of Open Access Journals (Sweden)

Gino Boily

Full Text Available The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utilize ingested food. These mice are hypermetabolic, contain inefficient liver mitochondria, and have elevated rates of lipid oxidation. When challenged with a 40% reduction in caloric intake, normal mice maintained their metabolic rate and increased their physical activity while the metabolic rate of SirT1-null mice dropped and their activity did not increase. Moreover, CR did not extend lifespan of SirT1-null mice. Thus, SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction.

33 CFR 147.817 - Sir Douglas Morpeth Tension Leg Platform safety zone.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Sir Douglas Morpeth Tension Leg... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.817 Sir Douglas Morpeth Tension Leg Platform safety zone. (a) Description. The Sir Douglas Morpeth Tension Leg Platform (Morpeth...

Robert's rules of order

CERN Document Server

Robert, Henry M; Balch, Thomas J; Seabold, Daniel E; Gerber, Shmuel

2011-01-01

The only authorized edition of the classic work on parliamentary procedure, with new and enhanced features, including how to conduct electronic meetings. Robert's Rules of Order is the book on parliamentary procedure for parliamentarians and anyone involved in an organization, association, club, or group and the authoritative guide to smooth, orderly, and fairly conducted meetings and assemblies. This newly revised edition is the only book on parliamentary procedure to have been updated since 1876 under the continuing program of review established by General Henry M. Robert himself, in cooperation with the official publisher of Robert's Rules. The eleventh edition has been thoroughly revised to address common inquiries and incorporate new rules, interpretations, and procedures made necessary by the evolution of parliamentary procedure, including new material relating to electronic communication and "electronic meetings."

Robert Cailliau honoured by Belgium

CERN Multimedia

2004-01-01

On 15 November, Robert Cailliau received the distinction of Commandeur de l'Ordre de Léopold from Belgium, his home country, for his pioneering work in developing the World Wide Web. Robert Cailliau worked closely with Tim Berners-Lee, the inventor of the Web.

New Processing of Spaceborne Imaging Radar-C (SIR-C) Data

Science.gov (United States)

Meyer, F. J.; Gracheva, V.; Arko, S. A.; Labelle-Hamer, A. L.

2017-12-01

The Spaceborne Imaging Radar-C (SIR-C) was a radar system, which successfully operated on two separate shuttle missions in April and October 1994. During these two missions, a total of 143 hours of radar data were recorded. SIR-C was the first multifrequency and polarimetric spaceborne radar system, operating in dual frequency (L- and C- band) and with quad-polarization. SIR-C had a variety of different operating modes, which are innovative even from today's point of view. Depending on the mode, it was possible to acquire data with different polarizations and carrier frequency combinations. Additionally, different swaths and bandwidths could be used during the data collection and it was possible to receive data with two antennas in the along-track direction.The United States Geological Survey (USGS) distributes the synthetic aperture radar (SAR) images as single-look complex (SLC) and multi-look complex (MLC) products. Unfortunately, since June 2005 the SIR-C processor has been inoperable and not repairable. All acquired SLC and MLC images were processed with a course resolution of 100 m with the goal of generating a quick look. These images are however not well suited for scientific analysis. Only a small percentage of the acquired data has been processed as full resolution SAR images and the unprocessed high resolution data cannot be processed any more at the moment.At the Alaska Satellite Facility (ASF) a new processor was developed to process binary SIR-C data to full resolution SAR images. ASF is planning to process the entire recoverable SIR-C archive to full resolution SLCs, MLCs and high resolution geocoded image products. ASF will make these products available to the science community through their existing data archiving and distribution system.The final paper will describe the new processor and analyze the challenges of reprocessing the SIR-C data.

Development of SIR-C Ground Calibration Equipment

Science.gov (United States)

Freeman, A.; Azeem, M.; Haub, D.; Sarabandi, K.

1993-01-01

SIR-C/X-SAR is currently scheduled for launch in April 1994. SIR-C is an L-Band and C-Band, multi-polarization spaceborne SAR system developed by NASA/JPL. X- SAR is an X-Band SAR system developed by DARA/ASI. One of the problems involved in calibrating the SIR-C instrument is to make sure that the horizontal (H) and vertical (V) polarized beams are aligned in the azimuth direction, i.e.. that they are pointing in the same direction. This is important if the polarimetric performance specifications for the system are to be met. To solve this problem, we have designed and built a prototype of a low-cost ground receiver capable of recording received power from two antennas, one H-polarized, the other V-polarized. The two signals are mixed to audio then recorded on the left and right stereo channels of a standard audio cassette player. The audio cassette recording can then be played back directly into a Macintosh computer, where it is digitized. Analysis of.

Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.

Science.gov (United States)

Gallo, Christopher M; Smith, Daniel L; Smith, Jeffrey S

2004-02-01

The Saccharomyces cerevisiae Sir2 protein is an NAD(+)-dependent histone deacetylase (HDAC) that functions in transcriptional silencing and longevity. The NAD(+) salvage pathway protein, Npt1, regulates Sir2-mediated processes by maintaining a sufficiently high intracellular NAD(+) concentration. However, another NAD(+) salvage pathway component, Pnc1, modulates silencing independently of the NAD(+) concentration. Nicotinamide (NAM) is a by-product of the Sir2 deacetylase reaction and is a natural Sir2 inhibitor. Pnc1 is a nicotinamidase that converts NAM to nicotinic acid. Here we show that recombinant Pnc1 stimulates Sir2 HDAC activity in vitro by preventing the accumulation of NAM produced by Sir2. In vivo, telomeric, rDNA, and HM silencing are differentially sensitive to inhibition by NAM. Furthermore, PNC1 overexpression suppresses the inhibitory effect of exogenously added NAM on silencing, life span, and Hst1-mediated transcriptional repression. Finally, we show that stress suppresses the inhibitory effect of NAM through the induction of PNC1 expression. Pnc1, therefore, positively regulates Sir2-mediated silencing and longevity by preventing the accumulation of intracellular NAM during times of stress.

Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states.

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Stephanie Kueng

Full Text Available Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM loci in budding yeast. We have performed a detailed biochemical and genetic analysis of the largest Sir protein, Sir4. The N-terminal half of Sir4 is dispensable for SIR-mediated repression of HM loci in vivo, except in strains that lack Yku70 or have weak silencer elements. For HM silencing in these cells, the C-terminal domain (Sir4C, residues 747-1,358 must be complemented with an N-terminal domain (Sir4N; residues 1-270, expressed either independently or as a fusion with Sir4C. Nonetheless, recombinant Sir4C can form a complex with Sir2 and Sir3 in vitro, is catalytically active, and has sedimentation properties similar to a full-length Sir4-containing SIR complex. Sir4C-containing SIR complexes bind nucleosomal arrays and protect linker DNA from nucleolytic digestion, but less effectively than wild-type SIR complexes. Consistently, full-length Sir4 is required for the complete repression of subtelomeric genes. Supporting the notion that the Sir4 N-terminus is a regulatory domain, we find it extensively phosphorylated on cyclin-dependent kinase consensus sites, some being hyperphosphorylated during mitosis. Mutation of two major phosphoacceptor sites (S63 and S84 derepresses natural subtelomeric genes when combined with a serendipitous mutation (P2A, which alone can enhance the stability of either the repressed or active state. The triple mutation confers resistance to rapamycin-induced stress and a loss of subtelomeric repression. We conclude that the Sir4 N-terminus plays two roles in SIR-mediated silencing: it contributes to epigenetic repression by stabilizing the SIR-mediated protection of linker DNA; and, as a target of phosphorylation, it can destabilize silencing in a regulated manner.

SIR-ZEE: plataforma tecnológica para el desarrollo local SIR-ZEE: technology platform for local development

Directory of Open Access Journals (Sweden)

Marlen Treviño Villalobos

2012-11-01

Full Text Available El Sistema de Información Regional de la Zona Económica Especial (SIR-ZEE nació en Costa Rica aproximadamente en 1998, cuando se concibió la idea de crear un sistema informático para recopilar, gestionar y ofrecer temáticas generadas en forma digital por diferentes entidades públicas y privadas. En el 2008, con los fondos del Programa de Regionalización Interuniversitaria del Consejo Nacional de Rectores, se aprobó la iniciativa SIR-ZEE, Plataforma Tecnológica para el Desarrollo Local, que buscó fortalecer las capacidades productivas y las capacidades de gobernabilidad en la Región Huetar Norte mediante el acceso a la información oportuna y relevante para el desarrollo económico local. Este artículo tiene como objetivo mostrar no solo la relevancia de un sistema de información en la planificación del desarrollo local, sino también que, en la actualidad, el SIR-ZEE se está convirtiendo en una ventaja competitiva para la Región Huetar Norte, ya que facilita el proceso de toma decisiones. Los principales resultados obtenidos al final de la iniciativa fueron una propuesta metodológica para la elaboración de planes estratégicos de desarrollo local en la Región Huetar Norte, la sensibilización de los actores locales sobre la participación ciudadana en las diferentes fases de la planificación, un diagnóstico territorial con el valor agregado de contar con la información georreferenciada y disponible en un sitio web, y avances en la elaboración del Plan estratégico de desarrollo local.The Regional Information System of the Special Economic Zone (SIR-ZEE was born about the year 1998 as a computer system to collect, manage and offer thematic generated in digital format by different public and private entities. In 2008, with the funds of Interuniversity Regionalization Program the National Council of Rectors approved the initiative SIR- ZEE: Platform Technology for Local Development which sought to strengthen productive

Geim, Prof. Sir Andre Konstantin

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...

Sir John Meurig Thomas.

Science.gov (United States)

Thomas, John Meurig

2013-10-11

"My greatest achievement has been to combine being a teacher, a researcher, and a popularizer of science for over 50 years. My worst nightmare is to find myself dumbstruck when I am about to give a lecture …︁" This and more about Sir John Meurig Thomas can be found on page 10938. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Sir Karl Popper and Education

Science.gov (United States)

McNamara, D. R.

1978-01-01

Sir Karl Popper is one of England's most distinguished contemporary philosophers and it is surprising that his thought has not permeated and informed educational discussion. This paper suggests that educationists have much to learn from Karl Popper's writings and explores ways in which his ideas can illuminate and advance discussion about…

Thomas, Prof. Sir John Meurig

Indian Academy of Sciences (India)

Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage ... Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more.

Constitutive Relation of Engineering Material Based on SIR Model and HAM

Directory of Open Access Journals (Sweden)

Haoxiang He

2014-01-01

Full Text Available As an epidemic mathematical model, the SIR model represents the transition of the Susceptible, Infected, and Recovered. The profound implication of the SIR model is viewed as the propagation and dynamic evolutionary process of the different internal components and the characteristics in a complex system subject to external effect. The uniaxial stress-strain curve of engineering material represents the basic constitutive relation, which also represents the damage propagation in the units of the damaged member. Hence, a novel dynamic stress-strain model is established based on the SIR model. The analytical solution and the approximate solution for the proposed model are represented according to the homotopy analysis method (HAM, and the relationship of the solution and the size effect and the strain rate is discussed. In addition, an experiment on the size effect of confined concrete is carried out and the solution of SIR model is suitable for simulation. The results show that the mechanical mechanism of the parameters of the uniaxial stress-strain model proposed in this paper reflects the actual characteristics of the materials. The solution of the SIR model can fully and accurately show the change of the mechanical performance and the influence of the size effect and the strain rate.

Robert Aumann

DEFF Research Database (Denmark)

Hansen, Pelle Guldborg

2007-01-01

In this interview Nobel Prize Winner Robert Aumann talks about how he was initially drawn into game theory, when he came to think of formalizing the folk-theorem, the proper role of game theory in relation to other disciplines and why behavioral game theory probably won't last long.......In this interview Nobel Prize Winner Robert Aumann talks about how he was initially drawn into game theory, when he came to think of formalizing the folk-theorem, the proper role of game theory in relation to other disciplines and why behavioral game theory probably won't last long....

Scientific objectives and selection of targets for the SMART-1 Infrared Spectrometer (SIR)

Science.gov (United States)

Basilevsky, A. T.; Keller, H. U.; Nathues, A.; Mall, U.; Hiesinger, H.; Rosiek, M.

2004-12-01

The European SMART-1 mission to the Moon, primarily a testbed for innovative technologies, was launched in September 2003 and will reach the Moon in 2005. On board are several scientific instruments, including the point-spectrometer SMART-1 Infrared Spectrometer (SIR). Taking into account the capabilities of the SMART-1 mission and the SIR instrument in particular, as well as the open questions in lunar science, a selection of targets for SIR observations has been compiled. SIR can address at least five topics: (1) Surface/regolith processes; (2) Lunar volcanism; (3) Lunar crust structure; (4) Search for spectral signatures of ices at the lunar poles; and (5) Ground truth and study of geometric effects on the spectral shape. For each topic we will discuss specific observation modes, necessary to achieve our scientific goals. The majority of SIR targets will be observed in the nadir-tracking mode. More than 100 targets, which require off-nadir pointing and off-nadir tracking, are planned. It is expected that results of SIR observations will significantly increase our understanding of the Moon. Since the exact arrival date and the orbital parameters of the SMART-1 spacecraft are not known yet, a more detailed planning of the scientific observations will follow in the near future.

King, Prof. Sir David Anthony

Indian Academy of Sciences (India)

Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.

Éloge to Robert Fox

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Efthymios Nicolaidis

2017-12-01

Full Text Available The 20th Alexandre Koyré Medal awarded since 1968 to prominent historians of science was awarded to Robert Fox, leading historian of European science of the period from the 18th to the beginnings of the 20th century. The Medal was presented to Robert Fox during the 7th International Conference of the European Society for the History of Science, Prague, 23 September 2016, and the Éloge describes his career and work.

Robert W Floyd

Indian Academy of Sciences (India)

scientists - Zohar Manna, an authority on the verification of software systems, Robert. Tarjan ... He began as a self taught computer operator, and then went ... important subfields of computer science: the theory of parsing, the semantics of.

90Sr content in 90Y-labeled SIR-spheres and Zevalin.

Science.gov (United States)

Metyko, John; Erwin, William; Poston, John; Jimenez, Sandra

2014-11-01

Three different 90Y internally administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures atMD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize 90Y-labeled microspheres, while Zevalin is an 90Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from 90Y production methods. The 90Y in SIR-Spheres and Zevalin are produced from a 90Sr/90Y generator, which leaves measurable quantities of 90Sr in the final product. TheraSphere 90Y is produced in a nuclear reactor which results in a large number of impurities, most notably 88Y and 91Y. Product information sheets reference these impurities with specific limits given. These limits represent a tiny fraction of the total product activity, and in the case of TheraSphere and SIR-Spheres gamma-emitting impurities, this has been verified in the literature. An analysis of 90Sr impurities in SIR-Spheres and Zevalin is presented in this paper. Impurity quantities were found to be within the vendors’ documented limits.

Whither Sir William?

Directory of Open Access Journals (Sweden)

Stephen J. Greenberg, MSLS, PhD

2017-04-01

Full Text Available There are times when something is simply so familiar that we can no longer see it at all. It can be a story, or a concept, or even a flesh-and-blood person. Familiarity breeds not only contempt, but a kind of invisibility as well. For too many of us, such is the case with Sir William Osler. In his time (1849–1919, many considered him to be one of the greatest practitioners, teachers, and writers ever in the field of medicine. He was instrumental in the founding of the Medical Library Association (MLA and was elected its second president.

SIRS Digues 2.0: A Cooperative Software For Levees Management

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Moins Isabelle

2016-01-01

Full Text Available SIRS Digues is a computing tool that makes informations on levees more durable and accessible in order to enhance their management. The first version of the software, which was IRSTEA’s initiative, was deployed in 2004. The second version was released in 2015. This article aims at pointing out the innovative aspects of this last version. They concern thematic and functionalities, computing technics and architecture, and last but not least, the business model chosen in order to build a long lasting software. The software’s kernel is sketched to propose a general description of levees: it focuses on description of the levees and linked objects, on disorders that affects them, on works... Most of these topics were already broached by the first version. The kernel of the version 2 may be extended using optional thematic modules. These modules concern: vegetation monitoring, reporting (in coherence with current French regulatory requirements, riverbanks, riverbed... Main functionnalities perfomed by SIRS Digues V1 and V2 are : data structuring and centralisation, quick access to relevant data, reporting and mapping, etc. SIRS Digues 2.0 updates and improves already existing functionalities of the first version. SIRS Digues V2 relies on an documentoriented NoSQL database, CouchDB, and on geospatial libraries, Geotoolkit and Apache-SIS. SIRS Digues V2 was released with a copyleft license. Copyrights belong to the French levees managers’ society, “France Digues”, which acts as a cooperative. Members put their heads together in order to gather their financial capacities and fund software development. France Digues has got the technical and thematic expertise and supply various services to the members. This business model aims to ensure accessibility, durability and adaptability of the software.

Robert Oppenheimer

International Nuclear Information System (INIS)

Rival, M.

1995-01-01

Graduate from Harvard, reputed professor, founder of the first theoretical physics high school of the Usa, Robert Oppenheimer is nominated in 1942 scientific director of the ''Y project'', the research program for the nuclear weapon fabrication. This book describes its life and the evolution of the Los Alamos researches up to the first test, its opposition to the thermo-nuclear weapon, and the maccarthysm period. (A.B.)

C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.

Science.gov (United States)

Chiang, Wei-Chung; Tishkoff, Daniel X; Yang, Bo; Wilson-Grady, Joshua; Yu, Xiaokun; Mazer, Travis; Eckersdorff, Mark; Gygi, Steven P; Lombard, David B; Hsu, Ao-Lin

2012-09-01

FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4--homolog of mammalian SIRT6 and SIRT7 proteins--promotes DAF-16-dependent transcription and stress-induced DAF-16 nuclear localization. SIR-2.4 is required for resistance to multiple stressors: heat shock, oxidative insult, and proteotoxicity. By contrast, SIR-2.4 is largely dispensable for DAF-16 nuclear localization and function in response to reduced insulin/IGF-1-like signaling. Although acetylation is known to regulate localization and activity of mammalian FoxO proteins, this modification has not been previously described on DAF-16. We find that DAF-16 is hyperacetylated in sir-2.4 mutants. Conversely, DAF-16 is acetylated by the acetyltransferase CBP-1, and DAF-16 is hypoacetylated and constitutively nuclear in response to cbp-1 inhibition. Surprisingly, a SIR-2.4 catalytic mutant efficiently rescues the DAF-16 localization defect in sir-2.4 null animals. Acetylation of DAF-16 by CBP-1 in vitro is inhibited by either wild-type or mutant SIR-2.4, suggesting that SIR-2.4 regulates DAF-16 acetylation indirectly, by preventing CBP-1-mediated acetylation under stress conditions. Taken together, our results identify SIR-2.4 as a critical regulator of DAF-16 specifically in the context of stress responses. Furthermore, they reveal a novel role for acetylation, modulated by the antagonistic activities of CBP-1 and SIR-2.4, in modulating DAF-16 localization and function.

THE DEMOKTESIS OF ROBERT NOZICK A DEMOKTESIS DE ROBERT NOZICK

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Luiz Felipe Netto de Andrade e Silva Sahd

2008-04-01

Full Text Available the present article aims at reconstructing Robert Nozick’s cen-tral arguments about the extreme positions held by North American li-bertarians who do not distinguish between Welfare state and totalitarian state. Despite divergences on a pivotal question, that of the state, there are some affinities between Nozick and this current of thought. Contrary to the anarchist theory, the Minimal state is preferable to the state of nature as described by John locke.O presente artigo tem como objetivo reconstruir argumentos cen-trais, desenvolvidos por Robert Nozick, acerca das posições extremas que não diferenciam Estado-providência e Estado totalitário na política dos libertarianos norte-americanos, isto é, sobre as afinidades percebidas por Nozick com as teses desta corrente de pensamento, embora se afastando num ponto essencial: a questão do Estado. Ao contrário da teoria anar-quista, o Estado mínimo é preferível ao estado de natureza, tal como John locke o descreve.

SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

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Chi-Hsien Peng

2010-06-01

Full Text Available Retinal stem cells bear potency of proliferation, self-renewal, and differentiation into many retinal cells. Utilizing appropriate sensors one can effectively detect the self-renewal and aging process abilities. Silencing information regulator (SirT1, a member of the sirtuin family, is a NAD-dependent histone deacetylase and an essential mediator for longevity in normal cells by calorie restriction. We firstly investigate the SirT1 mRNA expression in retinal stem cells from rats and 19 human eyes of different ages. Results revealed that SirT1 expression was significantly decreased in in vivo aged eyes, associated with poor self-renewal abilities. Additionally, SirT1 mRNA levels were dose-dependently increased in resveratrol- treated retinal stem cells. The expression of SirT1 on oxidative stress-induced damage was significantly decreased, negatively correlated with the level of intracellular reactive oxygen species production. Treatment with resveratrol could effectively further reduce oxidative stress induced by H2O2 treatment in retinal stem cells. Importantly, the anti-oxidant effects of resveratrol in H2O2-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1. SirT1 expression provides a feasible sensor in assessing self-renewal and aging process in retinal stem cells. Resveratrol can prevent reactive oxygen species-induced damages via increased retinal SirT1 expression.

"Cet obscur objet du Désir"

Directory of Open Access Journals (Sweden)

Reto Melchior

1996-09-01

Full Text Available Luis Bunuel’s last film is based on Pierre Louÿs’ La Femme et le Pantin. This now forgotten bestseller, published in 1898, is drawn from Goya s painting El Pelele, in which four women are playing with a male puppet. In Pierre Louÿs’ novel this scene is inverted so that one woman with two faces plays with four men. In Cet Obscur Objet du Désir this “femme fatale” is interpreted by two actresses. The concentric structure of the film puts focus on a scene of being excluded from knowing. The technique of continually interrupting the flash-back sequences frustrates the audience because of its exclusion from the “real” course of events and gives rise to doubts whether the male protagonist tells the truth about his love-affair or whether he satisfies the curiosity of the audience by telling them Pierre Louÿs’ novel as his own story. This ambiguous art of narration mirrors Bunuel’s claim that the main topic of Cet Obscur Objet du Désir is frustration.

Sir Charles Scott Sherrington (1857–1952)

Indian Academy of Sciences (India)

Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from twentytwouniversities and ...

Sir Charles Scott Sherrington (1857–1952)

Indian Academy of Sciences (India)

2016-08-26

Aug 26, 2016 ... Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from ...

Sir Ronald Ross and the Malarial Parasite

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 7. Sir Ronald Ross and the Malarial Parasite - Discovery of its Route - From Man to Mosquito and Back. Shobhona Sharma. General Article Volume 11 Issue 7 July 2006 pp 4-13 ...

Sir Isaac Newton

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E. A. Venter

1964-03-01

Full Text Available Die geweldige oplewing van die Christelike wetenskaps- gedagte in ons geeslose tyd, is ongetwyfeld ’n haas onverklaar- bare verskynsel. Dwarsdeur die eeue het Christene ook wetenskap beoefen saam met ongelowiges, maar dit was eers in ons leeftyd dat die principia van die Christelike religie ook vrugbaar gemaak is vir die wetenskapsbeoefening. In hierdie verband sal die name van Dooyeweerd, Vollenhoven, Stoker e.a. steeds met eer vermeld word. Natuurlik het belydende Christene ook voorheen wel deeglik saamgewerk aan die gebou van die wetenskap. Die intieme verband tussen religie, wysbegeerte en wetenskaps­ beoefening is toe egter nog nie suiwer ingesien nie. Uit hier­ die tydperk dateer die arbeid van sir Isaac Newton.

Robert Adrian X / Robert Adrian X ; interv. Tilman Baumgärtel

Index Scriptorium Estoniae

Adrian X, Robert

2006-01-01

1997. a. Ljubljanas tehtud intervjuu 1972. aastast Viinis elava kanada kunstniku Robert Adrian X-ga (sünd. 1935), kes töötas 1970-ndate lõpul ja 1980-ndate alguses telefoni, faksi ja varaste kirjakstisüsteemidega kunstiprojektide kallal, osales 1970-ndate ja 1980-ndate multimeediaprojektides

Introduction to special issue: Robert Jay Kastenbaum (1932-2013).

Science.gov (United States)

Fulton, Robert; Klass, Dennis; Doka, Kenneth J; Kastenbaum, Beatrice

The three pieces in this section introduce the Festschrift celebrating the works and influence of Omega: Journal of Death and Dying's founding editor, Robert Kastenbaum. Robert Fulton, an early Associate Editor of the Journal begins with some personal reflections on Kastenbaum. Klass and Doka then describe the nature of the Festschrift. A closing coda by Robert Kastenbaum's wife, Beatrice Kastenbaum, reminds us of the person behind the work.

Robert Smithsoni ülevaade

Index Scriptorium Estoniae

1999-01-01

Ameerika maakunstniku Robert Smithsoni (1938-1973) retrospektiivnäitus 12. sept.-ni Stockholmi Moodsa Kunsti Muuseumis. Kunstnikule maailmakuulsuse toonud tööst, 1970. a. Utah' osariigi Suurde Soolajärve ehitatud spiraalmuulist "Spiral Jetty".

Sir Ronald Ross and the Malarial Parasite

Indian Academy of Sciences (India)

1997-08-20

Aug 20, 1997 ... In 1857, a General in the Indian Army, Sir C C G Ross and his wife Matilda .... generally low-caste Indians who required a fee before drinking the water and ... nary demand being made upon their systems, as by fatigue, chill,.

Permanence for a Delayed Nonautonomous SIR Epidemic Model with Density-Dependent Birth Rate

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Li Yingke

2011-01-01

Full Text Available Based on some well-known SIR models, a revised nonautonomous SIR epidemic model with distributed delay and density-dependent birth rate was considered. Applying some classical analysis techniques for ordinary differential equations and the method proposed by Wang (2002, the threshold value for the permanence and extinction of the model was obtained.

SIR-2 Data Normalization and Integration with M3 Data

Science.gov (United States)

Grumpe, A.; Felder, M. P.; Wöhler, C.; Mall, U.

2013-09-01

The point spectrometer SIR-2 on Chandrayaan-1 provided radiance spectra integrated over circular footprints of 200 m diameter in the wavelength range 934-2410.8 nm in 256 channels [1]. To analyze SIR-2 reflectance spectra in their spatial context, a coregistration to Chandrayaan-1 M³ hyperspectral images [2] as well as a correction for topography and thermal emission are inevitable. The thermal and topographic correction procedure is based on the surface temperature and a digital elevation model (DEM) inferred from M³ data. The corrected reflectance spectra are then normalized to a standard illumination and viewing geometry.

Radiographic Assessment of the Robert and Lateral Views in Trapeziometacarpal Osteoarthrosis.

Science.gov (United States)

Oheb, Jonathan; Lansinger, Yuri; Jansen, Joshua A; Nguyen, Jimmy Q; Porembski, Margaret A; Rayan, Ghazi M

2015-01-01

To evaluate the effectiveness of the Robert view in assessing trapeziometacarpal arthrosis and to compare the accuracy of the Robert and lateral views in staging trapeziometacarpal (TM) joint arthrosis. Patient demographics were obtained. Four participating raters reviewed 62 randomly selected thumb x-rays of patients presenting with thumb TM joint pain. Lateral and Robert-hyperpronation views were assessed using an analysis of 13 criteria. X-rays of 62 thumbs for 58 patients were evaluated. The average patients' age was 64 (47-87) and 51 (80%) were females. The majority of X-rays evaluated fell into stage 3. Stage 2 was the second most common level of arthritis encountered and the least was stage 1. More osteophytes were encountered in the trapezium than metacarpal on both the Robert and lateral views. The Robert view was superior in detecting osteophytes on the trapezium than the lateral view. Osteophyte size varied from 1.7 to 2 mm. The lateral view displayed 61 cases with dorsal metacarpal subluxation (98%). The Robert view displayed 48 cases (77%) with radial metacarpal subluxation and 9 cases (15%) with ulnar metacarpal subluxation. Thumb metacarpal adduction deformity was encountered on the lateral view in 20 cases (32%) whereas on the Robert view it was encountered in 14 cases (23%). Subchondral sclerosis was encountered on the Robert view in 56 thumbs (90%) while it was seen on the lateral view in 52 thumbs (84%). Pantrapezial arthritis involving the STT joint was encountered equally in 16 cases (26%) on the Robert view and the lateral views. The study found a moderate level of interrater reliability on both the lateral and Robert views. With the exception of osteophytes encountered on the trapezium versus the metacarpal, there were no other statistically significant findings. This study confirms that each of the Robert and lateral views offer unique information and combining both views enhances the ability to assess radiographic disease severity, and

Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression

International Nuclear Information System (INIS)

Chang, C.-J.; Hsu, C.-C.; Yung, M.-C.; Chen, K.-Y.; Tzao Ching; Wu, W.-F.; Chou, H.-Y.; Lee, Y.-Y.; Lu, K.-H.; Chiou, S.-H.; Ma, H.-I

2009-01-01

CD133-expressing glioma cells play a critical role in tumor recovery after treatment and are resistant to radiotherapy. Herein, we demonstrated that glioblastoma-derived CD133-positive cells (GBM-CD133 + ) are capable of self-renewal and express high levels of embryonic stem cell genes and SirT1 compared to GBM-CD133 - cells. To evaluate the role of SirT1 in GBM-CD133 + , we used a lentiviral vector expressing shRNA to knock-down SirT1 expression (sh-SirT1) in GBM-CD133 + . Silencing of SirT1 significantly enhanced the sensitivity of GBM-CD133 + to radiation and increased the level of radiation-mediated apoptosis. Importantly, knock-down of SirT1 increased the effectiveness of radiotherapy in the inhibition of tumor growth in nude mice transplanted with GBM-CD133 + . Kaplan-Meier survival analysis indicated that the mean survival rate of GBM-CD133 + mice treated with radiotherapy was significantly improved by Sh-SirT1 as well. In sum, these results suggest that SirT1 is a potential target for increasing the sensitivity of GBM and glioblastoma-associated cancer stem cells to radiotherapy.

Serum inflammatory markers in the elderly: are they useful in differentiating sepsis from SIRS?

Directory of Open Access Journals (Sweden)

Mahshid Talebi-Taher

2014-06-01

Full Text Available Differentiating sepsis from other noninfectious causes of systemic inflammation is often difficult in the elderly. The aim of this study was to evaluate the ability of C-reactive protein (CRP, Erythrocyte Sedimentation Rate (ESR, procalcitonin (PCT, and Interleukin-6 (IL-6 to identify elderly patients with sepsis. In this single center prospective observational study, we included all consecutive elderly patients admitted with suspected sepsis and systemic inflammatory response syndrome (SIRS in an emergency department. Blood samples for measuring CRP, PCT, IL-6, ESR and white blood cells (WBC count were taken at first day of admission. Sensitivity, specificity, positive and negative predictive values were calculated for each inflammatory markers being studied. A total of 150 elderly patients aged 65 and older, 50 with sepsis and 50 with SIRS, and fifty individuals in a normal health status were included. CRP exhibited the greatest sensitivity (98% and negative predictive value (98.6% and performed best in differentiating patients with sepsis from those with SIRS. In a receiver operating characteristic curve analysis, IL-6 performed best in distinguishing between SIRS and the control group (AUC 0.75, 95% CI. On the other hand, both CRP and ESR appeared to be a more accurate diagnostic parameter for differentiating sepsis from SIRS among elderly patients.

Sir William Jenner (1815-1898) and Queen Victoria.

Science.gov (United States)

Seddon, David; Queen Victoria

2004-08-01

This biographical note outlines the work of Sir William Jenner (1815-1898), court physician 1861-93 and President of the Royal College of Physicians 1881-8. He was the first to distinguish between typhoid and typhus both clinically and pathologically.

dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

Directory of Open Access Journals (Sweden)

Kushal Kr. Banerjee

2012-12-01

Full Text Available Sir2, an evolutionarily conserved NAD+-dependent deacetylase, has been implicated as a key factor in mediating organismal life span. However, recent contradictory findings have brought into question the role of Sir2 and its orthologs in regulating organismal longevity. In this study, we report that Drosophila Sir2 (dSir2 in the adult fat body regulates longevity in a diet-dependent manner. We used inducible Gal4 drivers to knock down and overexpress dSir2 in a tissue-specific manner. A diet-dependent life span phenotype of dSir2 perturbations (both knockdown and overexpression in the fat body, but not muscles, negates the effects of background genetic mutations. In addition to providing clarity to the field, our study contrasts the ability of dSir2 in two metabolic tissues to affect longevity. We also show that dSir2 knockdown abrogates fat-body dFOXO-dependent life span extension. This report highlights the importance of the interplay between genetic factors and dietary inputs in determining organismal life spans.

An Architecture for the Electronic Church: Oral Roberts University in Tulsa, Oklahoma.

Science.gov (United States)

Grubiak, Margaret M

2016-04-01

More than a university, Oral Roberts University in Tulsa, Oklahoma, was also the headquarters for evangelist Oral Roberts's electronic church. The electronic church in America, dominated by Christian evangelicals, used technology to spread the Gospel over radio airways and television signals to a dispersed audience. Yet evangelicals like Roberts also constructed ambitious campuses in real space and time. The architecture of Oral Roberts University visualized a modern and "populuxe" image for the electronic church in the 1960s and 1970s. The university's Prayer Tower purposely alluded to the Seattle Space Needle, aligning religion and the Space Age, and the campus's white, gold, and black color palette on late modern buildings created an image of aspirational luxury, conveying Roberts's health and wealth gospel. Oral Roberts University served as a sound stage for Roberts's radio and television shows, a pilgrimage point for his audience, and a university dedicated to training evangelicals in the electronic church.

Lahkunud maailmaparandaja Robert Lepikson jäi igavesti otsijaks / Kai Kalamees

Index Scriptorium Estoniae

Kalamees, Kai

2006-01-01

Ülevaade riigikogu liikme, endise siseministri, Tallinna linnapea ja Võru maavanema Robert Lepiksoni elukäigust, meenutused tuntud ühiskonnategelastelt. Lisad: Robert Lepikson; Kõva sõnaga mees. Vt. samas: Turvavaatleja vastutusrikas töö viimasel rallil; Ivar Raidam: Lepiksoni panus autosporti oli tohutu; Hans H. Luik: Respect, Robert!

Comparison of QSOFA score and SIRS criteria as screening mechanisms for emergency department sepsis.

Science.gov (United States)

Haydar, Samir; Spanier, Matthew; Weems, Patricia; Wood, Samantha; Strout, Tania

2017-11-01

The Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) score has been shown to accurately predict mortality in septic patients and is part of recently proposed diagnostic criteria for sepsis. We sought to ascertain the sensitive of the score in diagnosing sepsis, as well as the diagnostic timeliness of the score when compared to traditional systemic inflammatory response syndrome (SIRS) criteria in a population of emergency department (ED) patients treated in the ED, admitted, and subsequently discharged with a diagnosis of sepsis. Electronic health records of 200 patients who were treated for suspected sepsis in our ED and ultimately discharged from our hospital with a diagnosis of sepsis were randomly selected for review from a population of adult ED patients (N=1880). Data extracted included the presence of SIRS criteria and the qSOFA score as well as time required to meet said criteria. In this cohort, 94.5% met SIRS criteria while in the ED whereas only 58.3% met qSOFA. The mean time from arrival to SIRS documentation was 47.1min (95% CI: 36.5-57.8) compared to 84.0min (95% CI: 62.2-105.8) for qSOFA. The median ED "door" to positive SIRS criteria was 12min and 29min for qSOFA. Although qSOFA may be valuable in predicting sepsis-related mortality, it performed poorly as a screening tool for identifying sepsis in the ED. As the time to meet qSOFA criteria was significantly longer than for SIRS, relying on qSOFA alone may delay initiation of evidence-based interventions known to improve sepsis-related outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.

76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

Science.gov (United States)

2011-08-09

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Robert Leigh Kale, M.D., Decision and Order... Enforcement Administration, issued an Order to Show Cause to Robert Leigh Kale, M.D. (Registrant), of Fort... Certificate of Registration, BK9514375, issued to Robert Leigh Kale, M.D., be, and it hereby is, revoked. I...

Delineation of major geologic structures in Turkey using SIR-B data

Science.gov (United States)

Toksoz, M. N.; Pettengill, G. H.; Ford, P.; Gulen, L.

1984-01-01

Shuttle Imaging Radar-B (SIR-B) images of well mapped segments of major faults, such as the North Anatolian Fault (NAF) and East Anatolian Fault (EAF) will be studied to identify the prominent signatures that characterize the fault zones for those specific regions. The information will be used to delineate the unmapped fault zones in areas with similar geological and geomorphological properties. The data obtained from SIR-B images will be compared and correlated with the LANDSAT thematic mapper and seismicity alignments based on well constrained earthquake epicenters.

Military Housing Privatization Initiative (MHPI), Eglin AFB, Florida and Hurlburt Field, Florida. Final Environmental Impact Statement

Science.gov (United States)

2011-05-01

Gene G. Sanderson George E. Cox Gerald A. Rush* Gerald Goodson Ginny Graybiel Glenda L. Glover Gordon Eldridge Gordon Goodin Greg Artabasy Greg... Fanc ~np. Thank you very much. COLONEL CUMBIE: Thank you, sir. !Vlr. Robert Larson . MR. LARSON: My name is Robert Larson . The Military Housing

SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells

International Nuclear Information System (INIS)

Xie Yuexia; Zhang Jianghong; Shao Chunlin; Xu Yanwu

2012-01-01

Intratumoral hypoxia is an important contributory factor to tumor cell resistance to radiotherapy. SirT1, a nicotinamide adenine dinucleotide (NAD + )-dependent histone/protein deacetylase, has been linked to the decrease of radiation-induced DNA damage and seems to be critical for cancer therapy. The purpose of this study was to investigate the role of SirT1 in hypoxia-induced radiation response on hepatoma cells. It was found that the administration with resveratrol, a putative SirT1 activator, enhanced the resistance of HepG2 cells against radiation-induced DNA damage of MN formation under hypoxia condition; while nicotinamide, a well-known SirT1 inhibitor, sensitized this radiation damage. Nevertheless, pretreatment of cells with 10058-F4, a specific inhibitor of c-Myc, almost eliminated the nicotinamide-induced radiosensitive effect. Further studies revealed that resveratrol inhibited c-Myc protein accumulation via up-regulation of SirT1 expression and deacetylase activity, and this loss of c-Myc protein was abolished by inhibiting its degradation in the presence of MG132, a potent inhibitor of proteasome. In contrast, nicotinamide attenuated c-Myc protein degradation induced by radiation under hypoxia through inhibition of SirT1 deacetylase activity. Our findings suggest that SirT1 could serve as a novel potent target of radiation-induced DNA damage and thus as a potential strategy to advance the efficiency of radiation therapy in hepatoma entities. (author)

Genetics Home Reference: Roberts syndrome

Science.gov (United States)

... feet are located very close to the body (phocomelia). People with Roberts syndrome may also have abnormal ... may live into adulthood. A condition called SC phocomelia syndrome was originally thought to be distinct from ...

The susceptible-infected-recovered (SIR) model for viral marketing

Science.gov (United States)

Ismail, Siti Suhaila; Akil, Ku Azlina Ku; Chulan, Majdah; Sharif, Noorzila

2017-11-01

Viral marketing is a marketing strategy utilizes social media to spread information about a product or services provided. It is the most powerful way to share information in a short amount of time. The objective of this study is to investigate the dynamic of viral marketing within a time duration in the point of view of mathematics. This study used the epidemiological model known as Susceptible-Infected-Recovered (SIR). The model consists of a system of three differential equations with three state variables namely susceptible (S), infected (I) and recovered (R). It considers a case of SIR model with demography. Numerical experiments have been performed. The results show that viral marketing reaches its peak within two days. The online messages shared will become higher if the initial number of the infected individual has been increased.

Sir Karl Popper and his philosophy of physics

Science.gov (United States)

Jammer, Max

1991-12-01

The eminent mathematical physicist Sir Hermann Bondi once said: “There is no more to science than its method, and there is no more to its method than Popper has said.” Indeed, many regard Sir Karl Raimund Popper the greatest philosopher of science in our generation. Much of what Popper “has said” refers to physics, but physicists, generally speaking, have little knowledge of what he has said. True, Popper's philosophy of science and, in particular, his realistic interpretation of quantum mechanics deviates considerably from the generally accepted doctrine. But as Popper, rightly I think, points out, it is precisely the proliferation of divergent theories which promotes the growth of scientific knowledge; it would be a danger for physics if physicists were dogmatically tied to a single theory or would not test their theory against alternatives. It is for this purpose that, on the occasion of the nonagenarian celebration of Popper's birthday, the present essay has been written.

Tetra-amelia and splenogonadal fusion in Roberts syndrome

Energy Technology Data Exchange (ETDEWEB)

Ravel, T.J.L. de; Seftel, M.D.; Wright, C.A. [Univ. of the Witwatersrand, Johannesburg (South Africa)

1997-01-20

Roberts-SC phocomelia syndrome comprises limb deficiencies of variable severity, facial clefts, and other anomalies. Tetra-amelia may also be associated with facial clefts and similar anomalies. We report on a female infant with severe tetra-amelia, micrognathia, cleft palate, splenogonadal fusion, and premature centromere separation. We propose that this represents the severe expression of the Roberts-SC phocomelia syndrome. 18 refs., 6 figs.

Robert Lepiksoni maailm / Eha Komissarov

Index Scriptorium Estoniae

Komissarov, Eha, 1947-

2000-01-01

Näitus "Minu maailm. Robert Lepikson fotograafina ja kollektsionäärina" galeriis "Vaal". Väljas on loodusfotod, fotod autodest, kunstikogust Eduard Steinbergi (1937) ja Vladimir Nemuhhini (1925) maalid, paar Salvador Dali värvilist litograafiat

Remembering Robert Seydel

Directory of Open Access Journals (Sweden)

Lauren van Haaften­-Schick

2011-06-01

Full Text Available This January, while preparing a new course, Robert Seydel was struck and killed by an unexpected heart attack. He was a critically under-appreciated artist and one of the most beloved and admired professors at Hampshire College.At the time of his passing, Seydel was on the brink of a major artistic and career milestone. His Book of Ruth was being prepared for publication by Siglio Press. His publisher describes the book as: “an alchemical assemblage that composes the life of his alter ego, Ruth Greisman— spinster, Sunday painter, and friend to Joseph Cornell and Marcel Duchamp. Through collages, drawings, and journal entries from Ruth’s imagined life, Seydel invokes her interior world in novelistic rhythms.”This convergence of his professional triumph with the tragedy of his death makes now a particularly appropriate time to think about Robert Seydel and his work. This feature contains a selection of excerpts from Book of Ruth (courtesy of Siglio Press alongside a pair of texts remembering him and giving critical and biographical insights into his art and his person. These texts, from a former student and a colleague respectively, were originally prepared for Seydel's memorial at Hampshire College and have since been revised for publication in continent.

Roberts 22: a bipolar nebula with OH emission

International Nuclear Information System (INIS)

Allen, D.A.; Hyland, A.R.; Caswell, J.L.

1980-01-01

Roberts 22 is a bipolar reflection nebula illuminated by a hidden A2 Ie star. Most of its energy is radiated at infrared wavelengths. It also shows strong OH maser emission (OH 284.18 - 0.79) on the 1612 and 1665 MHz transitions, generally similar to the masers associated with M stars having infrared excesses. But the system contains no late-type star. This remarkable assemblage of attributes makes Roberts 22 unique; however, it is probably a key member of the newly-recognized population of bipolar nebulae. From an analysis of the properties of Roberts 22 some published interpretations of other bipolar nebulae are questioned, in particular the derivation of spectral types for their underlying stars by the assumption of photo-ionization of the gas, and their evolutionary description as proto-planetary nebulae. (author)

Verification of the linearity of the new SIR using sources of 64Cu and 99mTc

International Nuclear Information System (INIS)

Michotte, Carine

2012-02-01

The linearity of the new SIR electronics has been verified by looking for deviations from the exponential decay for several 64 Cu and 99m Tc sources. Data analyses are compared with the half-life used as a fixed or free parameter. It is concluded that no significant non-linearity is observed in the new SIR. For comparison, the same method has been applied to analyse existing data from the original SIR. (author)

SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation

International Nuclear Information System (INIS)

Xie, Yuexia; Tu, Wenzhi; Zhang, Jianghong; He, Mingyuan; Ye, Shuang; Dong, Chen; Shao, Chunlin

2015-01-01

Highlights: • γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells. • SirT1 played a protective role in regulating this bystander effect. • SirT1 contributed to the protective effects via elimination the accumulation of ROS. • The activity of c-Myc is critical for maintaining the protective role of SirT1. - Abstract: Radiation-induced bystander effect (RIBE) has important implications for secondary cancer risk assessment during cancer radiotherapy, but the bystander signaling processes, especially under hypoxic condition, are still largely unclear. The present study found that micronuclei (MN) formation could be induced in the non-irradiated HL-7702 hepatocyte cells after being treated with the conditioned medium from irradiated hepatoma HepG2 and SK-Hep-1 cells under either normoxia or hypoxia. This bystander response was dramatically diminished or enhanced when the SirT1 gene of irradiated hepatoma cells was overexpressed or knocked down, respectively, especially under hypoxia. Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation. But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference. Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion. These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved

SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation

Energy Technology Data Exchange (ETDEWEB)

Xie, Yuexia [Institute of Radiation Medicine, Fudan University, Shanghai (China); Central Laboratory, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai (China); Tu, Wenzhi; Zhang, Jianghong; He, Mingyuan; Ye, Shuang; Dong, Chen [Institute of Radiation Medicine, Fudan University, Shanghai (China); Shao, Chunlin, E-mail: clshao@shmu.edu.cn [Institute of Radiation Medicine, Fudan University, Shanghai (China)

2015-02-15

Highlights: • γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells. • SirT1 played a protective role in regulating this bystander effect. • SirT1 contributed to the protective effects via elimination the accumulation of ROS. • The activity of c-Myc is critical for maintaining the protective role of SirT1. - Abstract: Radiation-induced bystander effect (RIBE) has important implications for secondary cancer risk assessment during cancer radiotherapy, but the bystander signaling processes, especially under hypoxic condition, are still largely unclear. The present study found that micronuclei (MN) formation could be induced in the non-irradiated HL-7702 hepatocyte cells after being treated with the conditioned medium from irradiated hepatoma HepG2 and SK-Hep-1 cells under either normoxia or hypoxia. This bystander response was dramatically diminished or enhanced when the SirT1 gene of irradiated hepatoma cells was overexpressed or knocked down, respectively, especially under hypoxia. Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation. But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference. Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion. These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved.

SIR JOHN CRAWFORD MEMORIAL ADDRESS: Agriculture: The challenges of the 21st century

OpenAIRE

Beddington, Sir John

2012-01-01

The Sir John Crawford Memorial Address has been presented since 1985, in honour of the distinguished Australian civil servant, educator and agriculturalist in whose name the Crawford Fund was established. Sir John Crawford was a remarkable Australian who contributed at the highest levels, and was a passionate supporter of international agricultural research for development. This talk draws attention to four current and interrelated trends that suggest the world will be rather different by 202...

Magnetohydrodynamics and the earth's core selected works by Paul Roberts

CERN Document Server

Soward, Andrew M

2003-01-01

Paul Roberts'' research contributions are remarkable in their diversity, depth and international appeal. Papers from the Paul Roberts'' Anniversary meeting at the University of Exeter are presented in this volume. Topics include geomagnetism and dynamos, fluid mechanics and MHD, superfluidity, mixed phase regions, mean field electrodynamics and the Earth''s inner core. An incisive commentary of the papers puts the work of Paul Roberts into historical context. Magnetohydrodynamics and the Earth''s Core provides a valuable source of reference for graduates and researchers working in this area of geoscience.

[Roberts-SC phocomelia syndrome].

Science.gov (United States)

Musfeld, D A; Bühler, E M; Heinzl, S

2001-01-01

The Roberts-SC phocomelia syndrome is a rare autosomal recessive inherited disorder clinically manifested by tetraphocomelia, pre- and postnatal growth retardation, and craniofacial abnormalities (skull, eyes, lip, and palate), accompanied at times by centromer puffing and splitting, renal abnormalities, heart defect, clitoral or penile enlargement, and bilateral corneal opacities. Mental retardation is common in surviving patients.

Stability analysis of the Euler discretization for SIR epidemic model

International Nuclear Information System (INIS)

Suryanto, Agus

2014-01-01

In this paper we consider a discrete SIR epidemic model obtained by the Euler method. For that discrete model, existence of disease free equilibrium and endemic equilibrium is established. Sufficient conditions on the local asymptotical stability of both disease free equilibrium and endemic equilibrium are also derived. It is found that the local asymptotical stability of the existing equilibrium is achieved only for a small time step size h. If h is further increased and passes the critical value, then both equilibriums will lose their stability. Our numerical simulations show that a complex dynamical behavior such as bifurcation or chaos phenomenon will appear for relatively large h. Both analytical and numerical results show that the discrete SIR model has a richer dynamical behavior than its continuous counterpart

L’économie politique du désir dans le rituel et le militantisme au SriLanka

Directory of Open Access Journals (Sweden)

Wim Van Daele

2013-03-01

Full Text Available Le désir est au cœur des interactions complexes entre le développement et la religion. Cet article examine ses différentes expressions, comme étant une des préoccupations fondamentales de nombreuses religions, qui motivent à la fois le développement et les alternatives au développement. Au SriLanka, face au changement social, la forme néolibérale et mondialisée du développement est comprise et réinterprétée à travers des idiomes et des formations locales du désir. L’économie néolibérale cultive le désir et mène à un accroissement présumé de la présence des preta (fantômes affamés et avides qui se manifestent parfois au moment de la mort d’une personne. Les fantômes affamés, en tant que formations fétichisées du désir, trouvent un écho chez les consommateurs et les entrepreneurs, qui montrent unappétit insatiable vis-à-vis d’une richesse matérielle en constante croissance. Ainsi, l’apaisement ritualisé des fantômes affamés et le militantisme social de groupes tels que le Movement for National Land and Agricultural Reform (MONLAR sont clairement liés par leur préoccupation mutuelle face à l’insécurité existentielle des êtres humains et non humains, causée par un désir excessif et déséquilibré. L’action rituelle et le militantisme social divergent toutefois dans la formulation explicite de leurs préoccupations spécifiques concernant le désir. Le rituel matérialise et condense l’angoisse liée au désir, alors que le militantisme social décrit la fétichisation du désir en termes économiques, politiques et scientifiques plus abstraits.

Max Weber and Robert Michels.

Science.gov (United States)

Scaff, Lawrence A.

1981-01-01

This paper investigates the unique intellectual partnership of Max Weber and Robert Michels, with particular emphasis on Weber's influence on Michel's inquiry into the sociology of parties and organization. Concludes with an evaluation of the import of Weber's critique of Michels' work. (DB)

Steven Hawking with Robert Aymar

CERN Multimedia

Maximilien Brice

2006-01-01

Steven Hawking is seen meeting with CERN's Director-General, Robert Aymar. Hawking visited CERN between 24 September and 1 October 2006. During his stay he gave two lectures and toured the LHC, which may provide insights into Hawking's most famous area of study, black holes.

Anthony ROBERTS 5 March 1948 – 16 January 2008

CERN Multimedia

TS Department

2008-01-01

We deeply regret to announce the death of Mr Anthony ROBERTS on 16 January 2008. Mr ROBERTS, born on 05.03.1948, worked in the HR Department and had been employed at CERN since 01.06.1973. The Director-General has sent his family a message of condolence on behalf of the CERN staff. Social Affairs Service Human Resources Department

Hoarding symptoms among psychiatric outpatients: confirmatory factor analysis and psychometric properties of the Saving Inventory – Revised (SI-R

Directory of Open Access Journals (Sweden)

Siau Pheng Lee

2016-10-01

Full Text Available Abstract Background The growing interest in problematic hoarding as an independent clinical condition has led to the development of the Saving Inventory-Revised (SI-R to assess hoarding phenomenology. The SI-R is one of the most widely used instruments to measure hoarding symptoms; however, it lacks validation in non-Western samples. Methods The current study examined the construct, convergent, and discriminant validity of the SI-R among 500 outpatients at a psychiatric hospital in Singapore. The three-factor structure solution of the SI-R was fitted in a confirmatory factor analysis. Results The final model achieved mediocre fit (χ2 = 1026.02, df = 186; RMSEA = 0.095, SRMR = 0.06; CFI = 0.86; NNFI = 0.85. Two reverse-coded items (items 2 and 4 were removed due to insufficient factor loadings, resulting in the modified 21-item SI-R (SIR-21. Our findings indicate the need to further examine the construct validity of the SI-R, particularly in non-Western samples. Nonetheless, correlations with other hoarding-related constructs, such as anxiety (Beck Anxiety Inventory and depression (Beck Depression Inventory-II, supported the convergent and discriminant validity of the SIR-21 in our sample. Conclusions Findings in our current majority Chinese sample were consistent with previous observations from other Chinese samples. Implications were discussed from a cross-cultural perspective, such as cultural emphasis on saving for future use and overlap between the concepts of discarding and acquiring in Chinese samples. Future studies should also examine differences among other ethnic groups (e.g., Malay, Indian.

ENGLISH, JUNIOR YEAR, SECOND SEMESTER. HIGH SCHOOL TELEVISION SERIES, SEMINAR--63.

Science.gov (United States)

GANCZEWSKI, JOAN D.

NINETY TELECAST OUTLINES ARE INCLUDED. THE CLASS WAS BROADCASTED FIVE MORNINGS A WEEK FOR 18 WEEKS. THE TELECAST BEGAN WITH THE ROMANTIC PERIOD, INCLUDING ROBERT BURNS, ROBERT LOUIS STEVENSON, THE LAKE POETS, SIR WALTER SCOTT, LAMB, HAZLITT, LORD BYRON, P.B. SHELLEY, JOHN KEATS, AND JANE AUSTEN. LESSONS ON GRAMMAR, SPELLING, AND THE FIRST…

Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions

Directory of Open Access Journals (Sweden)

Christian eLinke

2013-07-01

Full Text Available The Forkhead box family of transcription factors is evolutionary conserved from yeast to higher eukaryotes and its members are involved in many physiological processes including metabolism, DNA repair, cell cycle, stress resistance, apoptosis and aging. In budding yeast, four Forkhead transcription factors were identified, namely Fkh1, Fkh2, Fhl1, and Hcm1, which are implicated in chromatin silencing, cell cycle regulation and stress response. These factors impinge transcriptional regulation during cell cycle progression, and histone deacetylases play an essential role in this process, e.g. the nuclear localisation of Hcm1 depends on Sir2 activity, whereas Sin3/Rpd3 silence cell cycle specific gene transcription in G2/M phase. However, a direct involvement of Sir2 in Fkh1/Fkh2-dependent regulation of target genes is at present unknown. Here, we show that Fkh1 and Fkh2 associate with Sir2 in G1 and M phase, and that Fkh1/Fkh2-mediated activation of reporter genes is antagonized by Sir2. We further report that Sir2 overexpression strongly affects cell growth in an Fkh1/Fkh2-dependent manner. In addition, Sir2 regulates the expression of the mitotic cyclin Clb2 through Fkh1/Fkh2-mediated binding to the CLB2 promoter in G1 and M phase. We finally demonstrate that Sir2 is also enriched at the CLB2 promoter under stress conditions, and that the nuclear localization of Sir2 is dependent on Fkh1 and Fkh2. Taken together, our results show a functional interplay between Fkh1/Fkh2 and Sir2 suggesting a novel mechanism of cell cycle repression. Thus, in budding yeast, not only the regulation of G2/M gene expression but also the protective response against stress could be directly coordinated by Fkh1 and Fkh2.

The inauguration of Robert-Bourassa Park at James Bay

International Nuclear Information System (INIS)

Valiquette, M.

1997-01-01

Robert Bourassa's contributions to the hydroelectric development at James Bay were acknowledged with the inauguration of a park in the ex-prime minister's name. Phase 1 of the James Bay hydroelectric project constituted the world's biggest construction site, employing more than 180,000 people from beginning to project completion. The James Bay project allowed Hydro-Quebec to gain one of the world's largest electric power utilities and to gain significant competitive edge over its competitors. The Robert Bourassa Park contains a picnic area and a visitor interpretation centre which describes the history of the project. A sequence of 5 signposts summarize the contributions that Robert Bourassa made to the megaproject which cost over $20.6 billion. The complex consists of 65 turbines which produce 15,235 megawatts of electricity. 1 fig

Conferencias a la Memoria de la Dra. Lydia J. Roberts 1967, 1969-1973 (Conferences in Memory of Dr. Lydia J. Roberts 1967, 1969-1973).

Science.gov (United States)

Puerto Rico Univ., Rio Piedras.

This publication includes eleven lectures presented as part of a conference given honoring Dr. Lydia J. Roberts. Seven of the papers are written in the English language and four in Spanish. Most of the papers relate to the topic of nutrition, but a few pay tribute to Dr. Roberts in recognition of her distinguished leadership and teacher of human…

Sir James Reid and the Death of Queen Victoria: An Early Model for End-of-Life Care.

Science.gov (United States)

Abrams, Robert C

2015-12-01

An appraisal of the last ten days of Queen Victoria's life, viewed primarily from the perspective of her personal physician, Sir James Reid, is presented. Sir James' clinical encounters with his patient and the Royal Family are examined to reveal his strategic and medical thinking and gauge his level of success in basic palliative aims. It was found that the lack of effective medical interventions, tensions within the Royal Family, the importance of his post to Sir James' professional career, and the political ramifications unavoidably connected with the illness of a head of state, all presented challenges to Reid's efforts to ease the physical and emotional pain of Queen Victoria's dying. Key features of Sir James' approach included reliance on physician-patient and physician-family relationships, emphasis on emotional support for the patient, and the careful selection of interventions for the family. In the first years of the 20th century, an era when the contemporary concepts of palliative care, hospice, and family dynamics did not exist, Sir James' management of the Queen's final illness suggested an early model for end-of-life care. By the end of Queen Victoria's life, Sir James was seen to have preserved his patient's comfort and dignity, at the same time advancing family and societal acceptance of the death of this matriarchal figure. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Robert Wilson's Invitation to Insanity.

Science.gov (United States)

Stephens, Judith L.

The plays of stage director Robert Wilson are devices presenting alternative modes of perception to theatre audiences accustomed to verbal/aural structures of experience. Uniting his interests in the arts and therapy, his plays create a theatrical event promoting empathy with the perceptions of the mentally or physically handicapped and…

Double trisomy (48,XXX,+18) with features of Roberts syndrome

Energy Technology Data Exchange (ETDEWEB)

Descartes, M.; Longshore, J.W.; Crawford, E. [Univ. of Alabama, Birmingham, AL (United States)] [and others

1994-09-01

We report an infant with double trisomy 48,XXX,+18, who also displayed features of Roberts syndrome. All previously published cases with similar double trisomy have presented with features of trisomy 18 syndrome. The chromosome analysis done at birth revealed the double trisomy; parental chromosomes were normal. The proband presented with microbrachycephaly, unilateral cleft lip and palate, choanal atresia, midfacial capillary hemanioma, thin nares, shallow orbits, malformed ears, sparse hair, hypomelia of the upper limbs, rocker-bottom feet, auricular septal defect and agenesis of the corpus callosum. Characteristic features of Roberts syndrome included hypomelia, midfacial defects, and severe growth deficiency. Among the many different features reported in the literature for patients with trisomy 18 syndrome, the most consistent were growth deficiency, clenched fingers and congenital heart defects (e.g. VSD, ASD, PDA). Although some of our patient`s features such as cleft lip and cleft palate, low-set malformed ears, ASD, defects of the corpus callosum, choanal atresia, radial aplasia could also be seen in trisomy 18 syndrome (in 10-50% of the cases), her phenotype was more typical of Roberts syndrome because of symmetrical hypomelia and midfacial defects. Our patient`s chromosomes did not show premature separation of centromeric heterochromatin, a feature reported to occur in approximately one-half of individuals with Roberts syndrome. Sporadic aneuploidy involving different chromosomes has been found in lymphocyte cultures from some Roberts syndrome patients and is considered by some authors as a mitotic mutant. This aneuploidy is most likely to be chromosome gain. The simultaneous occurrence of trisomy X and 18 is extremely rare with only 11 cases having been reported in the literature. Our patient is unique since she has the double trisomy in addition to the characteristic features of Roberts syndrome.

Robert Nemiroff: Communicating Astronomy 365 Days a Year

Science.gov (United States)

Pullen, L.; Russo, P.

2010-06-01

Few astronomy communication projects are as well known or as widely disseminated as the Astronomy Picture of the Day (or APOD for short). Since its creation in 1995, it has popularised thousands of images and helped to explain the cosmos through informative captions. Impressively, the site shows no signs of slowing down and has amassed many loyal supporters. This success can be attributed to the two astronomers behind the project: Robert Nemiroff and Jerry Bonnell. CAPjournal has interviewed Robert to discover his view of APOD, and the lesser known issues that surround it.

The Timeless Legacy of Robert Koch

Indian Academy of Sciences (India)

Robert Koch was a German physician and scientist who made wide-ranging .... methods of bacterial staining so that bacteria could be visualized more easily and .... of whom became outstanding scientists in their own right, such as Friedrich.

SIR - small is safe [in reactor design

International Nuclear Information System (INIS)

Hayns, M.

1989-01-01

A joint USA-UK venture has been initiated to design a small nuclear reactor which offers low capital cost, greater flexibility and a potentially lower environmental impact. Called Safe Integral Reactor (SIR), the lead unit could be built in the United Kingdom Atomic Energy Authority's (UKAEA's) Winfrith site if the design is accepted by the UK Nuclear Installations Inspectorate (NII). This article describes the 320 MWe reactor unit that is the basis of the design being developed. (author)

Analysis of data acquired by Shuttle Imaging Radar SIR-A and Landsat Thematic Mapper over Baldwin County, Alabama

Science.gov (United States)

Wu, S.-T.

1985-01-01

Seasonally compatible data collected by SIR-A and by Landsat 4 TM over the lower coastal plain in Alabama were coregistered, forming a SIR-A/TM multichannel data set with 30 m x 30 m pixel size. Spectral signature plots and histogram analysis of the data were used to observe data characteristics. Radar returns from pine forest classes correlated highly with the tree ages, suggesting the potential utility of microwave remote sensing for forest biomass estimation. As compared with the TM-only data set, the use of SIR-A/TM data set improved classification accuracy of the seven land cover types studied. In addition, the SIR-A/TM classified data support previous finding by Engheta and Elachi (1982) that microwave data appear to be correlated with differing bottomland hardwood forest vegetation as associated with varying water regimens (i.e., wet versus dry).

Leaving Libertarianism: : Social Ties in Robert Nozick's New Philosophy

OpenAIRE

Herbjørnsrud, Dag

2002-01-01

SUMMARY This thesis Leaving Libertarianism: Social Ties in Robert Nozick s New Philosophy challenges the general and most widespread portrayals of the American philosopher Robert Nozick (1938-2002) by studying the notion of social ties in his later philosophy. The point of departure is the present descriptions of Nozick s philosophy. Mostly these depictions are based upon three postulates: That Nozick is an extreme individualist, that the libertarian Anarchy, State, and Utopia (1...

SIRS score on admission and initial concentration of IL-6 as severe acute pancreatitis outcome predictors.

Science.gov (United States)

Gregoric, Pavle; Pavle, Gregoric; Sijacki, Ana; Ana, Sijacki; Stankovic, Sanja; Sanja, Stankovic; Radenkovic, Dejan; Dejan, Radenkovic; Ivancevic, Nenad; Nenad, Ivancevic; Karamarkovic, Aleksandar; Aleksandar, Karamarkovic; Popovic, Nada; Nada, Popovic; Karadzic, Borivoje; Borivoje, Karadzic; Stijak, Lazar; Stefanovic, Branislav; Branislav, Stefanovic; Milosevic, Zoran; Zoran, Milosević; Bajec, Djordje; Djordje, Bajec

2010-01-01

Early recognition of severe form of acute pancreatitis is important because these patients need more agressive diagnostic and therapeutical approach an can develope systemic complications such as: sepsis, coagulopathy, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Dysfunction Syndrome (MODS), Multiple Organ Failure (MOF). To determine role of the combination of Systemic Inflammatory Response Syndrome (SIRS) score and serum Interleukin-6 (IL-6) level on admission as predictor of illness severity and outcome of Severe Acute Pancreatitis (SAP). We evaluated 234 patients with first onset of SAP appears in last twenty four hours. A total of 77 (33%) patients died. SIRS score and serum IL-6 concentration were measured in first hour after admission. In 105 patients with SIRS score 3 and higher, initial measured IL-6 levels were significantly higher than in the group of remaining 129 patients (72 +/- 67 pg/mL, vs 18 +/- 15 pg/mL). All nonsurvivals were in the first group, with SIRS score 3 and 4 and initial IL-6 concentration 113 +/- 27 pg/mL. The values of C-reactive Protein (CRP) measured after 48h, Acute Physiology and Chronic Health Evaluation (APACHE II) score on admission and Ranson score showed the similar correlation, but serum amylase level did not correlate significantly with Ranson score, IL-6 concentration and APACHE II score. The combination of SIRS score on admission and IL-6 serum concentration can be early, predictor of illness severity and outcome in SAP.

Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination.

Directory of Open Access Journals (Sweden)

Alison E Ringel

Full Text Available Sir2 is an NAD(+-dependent histone deacetylase required to mediate transcriptional silencing and suppress rDNA recombination in budding yeast. We previously identified Tdh3, a glyceraldehyde 3-phosphate dehydrogenase (GAPDH, as a high expression suppressor of the lethality caused by Sir2 overexpression in yeast cells. Here we show that Tdh3 interacts with Sir2, localizes to silent chromatin in a Sir2-dependent manner, and promotes normal silencing at the telomere and rDNA. Characterization of specific TDH3 alleles suggests that Tdh3's influence on silencing requires nuclear localization but does not correlate with its catalytic activity. Interestingly, a genetic assay suggests that Tdh3, an NAD(+-binding protein, influences nuclear NAD(+ levels; we speculate that Tdh3 links nuclear Sir2 with NAD(+ from the cytoplasm.

Investigating The Travelling Wave Solution For an SIR Endemic ...

African Journals Online (AJOL)

This paper presents the travelling wave solution for an SIR endemic disease model with no disease related death when the spatial spread of the susceptible is not negligible. In this case the disease is driven by both the susceptible and the infective classes. The population is open since the disease is habitually prevalent in ...

Science and controversy a biography of Sir Norman Lockyer

CERN Document Server

Meadows, A

2008-01-01

Sir Norman Lockyer left Nature, the world''s leading scientific journal, as his lasting memorial. But his life, and controversial theories, are an important part of science history. His ideas were at the forefront of public debate, and ranged from brilliant to perverse. This entertaining book is a fascinating insight into his eventful life

Buffels (Wes), Elsies, Sir Lowry's pass, Steenbras and Buffels (Oos)

CSIR Research Space (South Africa)

Heinecken, TJE

1982-06-01

Full Text Available This report is a synthesis of all available information on five of the smaller rivers discharging in to False bay combined as a single volume. The rivers dealt with are the Buffels (Wes), Elsies, Sir Lowry' Pass, Steenbras and Buffels (Oos). False...

Roberts syndrome: clinical and cytogenetic aspects

OpenAIRE

Mann, N P; Fitzsimmons, J; Fitzsimmons, E; Cooke, P

1982-01-01

Roberts syndrome is reported in two sibs of consanguineous parents. Both infants had severe tetraphocomelia, facial clefting, and other serious malformations. In addition they were found to have an unusual cytogenetic abnormality with distortion of the normal sister chromatid relationship in many chromosomes.

Simulation of emotional contagion using modified SIR model: A cellular automaton approach

Science.gov (United States)

Fu, Libi; Song, Weiguo; Lv, Wei; Lo, Siuming

2014-07-01

Emotion plays an important role in the decision-making of individuals in some emergency situations. The contagion of emotion may induce either normal or abnormal consolidated crowd behavior. This paper aims to simulate the dynamics of emotional contagion among crowds by modifying the epidemiological SIR model to a cellular automaton approach. This new cellular automaton model, entitled the “CA-SIRS model”, captures the dynamic process ‘susceptible-infected-recovered-susceptible', which is based on SIRS contagion in epidemiological theory. Moreover, in this new model, the process is integrated with individual movement. The simulation results of this model show that multiple waves and dynamical stability around a mean value will appear during emotion spreading. It was found that the proportion of initial infected individuals had little influence on the final stable proportion of infected population in a given system, and that infection frequency increased with an increase in the average crowd density. Our results further suggest that individual movement accelerates the spread speed of emotion and increases the stable proportion of infected population. Furthermore, decreasing the duration of an infection and the probability of reinfection can markedly reduce the number of infected individuals. It is hoped that this study will be helpful in crowd management and evacuation organization.

14 April 2014 - UK University College London Hospitals and National Health Service Foundation Trust Chairman R. Murley in the ATLAS cavern with CERN Head of Medical Applications S. Myers and Collaboration Spokesperson D. Charlton.

CERN Multimedia

Gadmer, Jean-Claude

2014-01-01

Mr Richard Murley Chairman Sir Robert Naylor Chief Executive University College London Hospitals (UCLH) – National Health Service (NHS) Foundation Trust United Kingdom of Great Britain and Northern Ireland

The Timeless Legacy of Robert Koch

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 9. The Timeless Legacy of Robert Koch - Founder of Medical Microbiology. Jaya S Tyagi. General Article Volume 11 Issue 9 September 2006 pp 20-28. Fulltext. Click here to view fulltext PDF. Permanent link:

Intrapartum diagnostic of Roberts syndrome - case presentation.

Science.gov (United States)

Socolov, Răzvan Vladimir; Andreescu, Nicoleta Ioana; Haliciu, Ana Maria; Gorduza, Eusebiu Vlad; Dumitrache, Florentin; Balan, Raluca Anca; Puiu, Maria; Dobrescu, Mihaela Amelia; Socolov, Demetra Gabriela

2015-01-01

Roberts syndrome is a rare disease, with multiple limb and skeletal abnormalities (called "pseudothalidomide disease"). There are only around 150 cases described in literature. We present a case of Roberts syndrome, diagnosed in moment of delivery, after a pregnancy without prenatal follow-up. The stillborn baby was naturally delivered by a 17-year-old primiparous woman at 38 weeks of amenorrhea. The pregnancy was not followed due to socioeconomic and family situation, and no prenatal ultrasound was performed. The male baby has 2650 g and presented several morphological abnormalities and tight double umbilical abdominal loop. The macroscopic evaluation showed: dolichocephaly, hypoplastic inferior maxilla with micrognathia, antimongoloid palpebral slant, pterygium colli, abnormal and lower implanted ears, superior limbs phocomelia, syndactyly at lower left limb and tetradactyly in all limbs, bilateral cryptorchidism, pancreatic aplasia. Roberts syndrome is a rare genetic disease with recessive autosomal transmission generated by mutations in ESCO2 gene, located on chromosome 8. The disease should be easy to diagnose by antenatal ultrasound examination, but in our case, the lack of prenatal follow-up determined the diagnostic at term. We believe consider this case is an argument towards introducing ultrasound-screening compulsory to all pregnancies. To identify a possible genetic mutation, further investigations of the parents are in progress, but classically the disease has a recessive autosomal transmission.

Robert Frost: Teacher "Earner, Learner, Yearner."

Science.gov (United States)

Vogel, Nancy Sue

An account of Robert Frost's teaching, along with an assessment of it, are presented. Material consulted includes Frost's published letters, prose, and poetry; Lawrance Thompson's authorized biography; Lesley Frost's "New Hampshire's Child: The Derry Journals of Lesley Frost;" and additional sources such as films and periodicals,…

Le continent noir du désir masculin : Colet et Flaubert, encore

OpenAIRE

Vinken, Barbara

2010-01-01

Il y a peu d’échanges de lettres qui surprennent le lecteur aussi douloureusement que celui entre Louise Colet et Gustave Flaubert. Rarement, l’espoir qui sommeille au fond de tout lecteur d’une histoire d’amour heureux fut à ce point frustré.Les études de Freud – un des plus grands sceptiques en matière d’amour – sur la vie sexuelle éclairent les vicissitudes du désir amoureux masculin. Les Lettres de Flaubert à Colet sont la mise en scène dramatique d’un désir qui suit les complications du ...

The meanings of J. Robert Oppenheimer

CERN Document Server

Banco, Lindsey Michael

2016-01-01

He called the first atomic bomb “technically sweet,” yet as he watched its brilliant light explode over the New Mexico desert in 1945 in advance of the black horrors of Hiroshima and Nagasaki, he also thought of the line from the Hindu epic The Bhagavad Gita: “I am become Death, the destroyer of worlds.” Physicist J. Robert Oppenheimer, the scientific director of the Manhattan Project, the single most recognizable face of the atomic bomb, and a man whose name has become almost synonymous with Cold War American nuclear science, was and still is a conflicted, controversial figure who has come to represent an equally ambivalent technology. The Meanings of J. Robert Oppenheimer examines how he has been represented over the past seven decades in biographies, histories, fiction, comics, photographs, film, television, documentaries, theater, and museums. Lindsey Michael Banco gathers an unprecedented group of cultural texts and seeks to understand the multiple meanings Oppenheimer has held in American popul...

Members of the Parliamentary Select Committee on Trade and Industry of the United Kingdom visit the CMS assembly hall.

CERN Multimedia

Patrice Loïez

2002-01-01

Left to right: Austin Ball, Martin O'Neill (Chairman), Richard Burden, Jonathan Djanogly, Lindsay Hoyle, Roger Berry, Linda Perham, Sir Robert Smith, Jackie Lawrence, Michel Della Negra, Tejinder Virdee, Ashok Kumar.

Kirjavahetus Kaarel Robert Pustaga / Karl Ast Rumor

Index Scriptorium Estoniae

Rumor, Karl, pseud., 1886-1971

2009-01-01

Kirjavahetus Rio de Janeiros elava Karl Ast Rumori ja New Yorgis elava Kaarel Robert Pusta vahel Eesti kongressi kokkukutsumise vajalikkuse, väliseesti ühingute ja nõukogude, ajakirjanduse ning üldise poliitilise olukorra teemadel

BOREAS RSS-15 SIR-C and Landsat TM Biomass and Landcover Maps of the NSA

Science.gov (United States)

Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Ranson, K. Jon

2000-01-01

As part of BOREAS, the RSS-15 team conducted an investigation using SIR-C, X-SAR, and Landsat TM data for estimating total above-ground dry biomass for the SSA and NSA modeling grids and component biomass for the SSA. Relationships of backscatter to total biomass and total biomass to foliage, branch, and bole biomass were used to estimate biomass density across the landscape. The procedure involved image classification with SAR and Landsat TM data and development of simple mapping techniques using combinations of SAR channels. For the SSA, the SIR-C data used were acquired on 06-Oct-1994, and the Landsat TM data used were acquired on 02-Sep-1995. The maps of the NSA were developed from SIR-C data acquired on 13-Apr-1994. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

Quantitative measurement of Y90 brehmmstrahlung images after of Y90 Sir-Spheres implantation to assess lung shunting

International Nuclear Information System (INIS)

Forwood, Nicholas J.; Pocock, Nicholas; Shin, Jane; Young, Andy M; Szeto, Edwin R.

2009-01-01

Full text: Background: In clinical practice the dose of Y 9 0 Sir-Spheres is calculated using a pre injection of Tc 9 9 m MAA. There is however a potential difference due to the different properties of Tc 9 9 m MAA and Y 9 0 Sir-Spheres. We assessed the concordance of lung shunting of Y 9 0 Sir-Spheres estimated using Y 9 0 Bremsstrahlung imaging, compared to shunting assessed using Tc 9 9 m MAA. Methods: 15 Patients were evaluated using 150-200 MBq of Tc 9 9 m MAA injected into the hepatic artery under angiographic guidance. Whole body images were acquired using a LEAP collimator (window of 140 kEv+/-10%). The patients were subsequently treated with Y 9 0 Sir-Spheres. After microspheres injection, whole body brehmsstrahlung images were acquired using a medium energy collimator (window settings of 75 kEv +/- 20%). Tc 9 9 m MAA images were paired with their corresponding bremsstrahlung image and lung shunting in the stu ides calculated simultaneously. Each paired dataset was analyzed by 5 operators. Results: The mean lung shunting for Tc 9 9 m MAA acquisition was 3.32% (SD 2.03) which was significantly lower than the lung shunting using the Y 9 0 acquisitions: mean 16.19% (SD of 6.43). The Pearson coefficient was r = 0.62 (p 9 0 Sir-Spheres bremsstrahlung imaging is higher than that calculated by Tc 9 9 m MAA imaging. The relationship is not sufficiently strong to use bremsstahlung imaging to retrospectively quantify the lung-to-liver shunting as indicated using Tc 9 9 M AA. Further studies are underway to assess the reliability of Tc 9 9 m MAA lung uptake calculations in determining the dose of Y 9 0 Sir-Spheres.

Milestones in plant sulfur research on sulfur-induced-resistance (SIR in Europe

Directory of Open Access Journals (Sweden)

Elke eBloem

2015-01-01

Full Text Available Until the 1970´s of the last century sulfur (S was mainly regarded as a pollutant being the main contributor of acid rain, causing forest dieback in central Europe. When Clean Air Acts came into force at the start of the 1980´s SO2 contaminations in the air were consequently reduced within the next years. S changed from an unwanted pollutant into a lacking plant nutrient in agriculture since agricultural fields were no longer fertilized indirectly by industrial pollution. S deficiency was first noticed in Brassica crops that display an especially high S demand because of its content of S-containing secondary metabolites, the glucosinolates. In Scotland, where S depositions decreased even faster than in continental Europe, an increasing disease incidence with Pyrenopeziza brassicae was observed in oilseed rape in the beginning 1990´s and the concept of sulfur-induced-resistance (SIR was developed after a relationship between the S status and the disease incidence was uncovered. Since then a lot of research was carried out to unravel the background of SIR in the metabolism of agricultural crops and to identify metabolites, enzymes and reactions, which are potentially activated by the S metabolism to combat fungal pathogens. The S status of the crop is affecting many different plant features such as color and scent of flowers, pigments in leaves, metabolite concentrations and the release of gaseous S compounds which are directly influencing the desirability of a crop for a variety of different organisms from microorganisms, over insects and slugs to the point of grazing animals.The present paper is an attempt to sum up the knowledge about the effect of the S nutritional status of agricultural crops on parameters that are directly related to their health status and by this to SIR. Milestones in SIR research are compiled, open questions are addressed and future projections were developed.

Does SOFA predict outcomes better than SIRS in Brazilian ICU patients with suspected infection? A retrospective cohort study

Directory of Open Access Journals (Sweden)

Regis Goulart Rosa

2017-11-01

Full Text Available We compared the discriminatory capacity of the sequential organ failure assessment (SOFA versus the systemic inflammatory response syndrome (SIRS score for predicting ICU mortality, need for and length of mechanical ventilation, ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition and SIRS (SIRS score ≥2 points. From January 2008 to December 2014, 1487 patients were admitted to the ICU due to suspected infection. SOFA ≥2 identified more septic patients than SIRS ≥2 (79.0% [n = 1175] vs. 68.5% [n = 1020], p  7 days (AUROC = 0.65 vs. 0.63, p = 0.004, and length of hospitalization >10 days (AUROC = 0.61 vs. 0.59, p 7 days.

Lieutenant General Robert L. Bullard: Understanding Small and Large Conflicts

Science.gov (United States)

2012-12-06

Publishing, 1925). 11 Robert L. Bullard, American Soldiers Also Fought ( Garden City, NY: Longmens and Green, 1936). 12 Ibid., V. 13 Ibid., VI...2005, 41-45. 53 Robert L. Bullard, “Among the Savage Moros,” Metropolitan Magazine, vol. XXIV:III (June 1906), 264. 19 increased during his...59 Bullard, “Among the Savage Moros,” 264. 22 intuitively knew that if he was to assist a partner, help the deprived, or fight an adversary, he

Robert Putnam : miks peaksime naabritega rohkem rääkima? / Robert Putnam ; interv. Külli-Riin Tigasson

Index Scriptorium Estoniae

Putnam, Robert

2006-01-01

26. mail Tallinnas toimuva Avatud Ühiskonna Foorumi peaesineja, Harvardi Ülikooli professor väidab, et mida paremini tuntakse oma naabreid, mida aktiivsemalt osaletakse kohalikus elus ning mida rohkem inimesed omavahel suhtlevad, seda paremaks ja turvalisemaks muutub nende elukeskkond. Lisad: Robert Putnam (sünd 1941); Kuidas kasvatada sotsiaalset kapitali?

“Trickster” and “Republican”: Robert Harley’s Political Career in the 1690s

Directory of Open Access Journals (Sweden)

Kiselev Aleksandr

2014-12-01

Full Text Available Despite the fact that Robert Harley is known as Tory politician, he began his career as a Whig politician. His grandfather and father were Presbyterians, and Robert Harley himself was a Presbyterian during his entire life. Harley’s family supported the Glorious Revolution of 1688. In 1689 Robert Harley was first elected to the House of Commons as a representative of the Whig party. Thanks to his wife’s Foley family, Robert Harley was elected as a commissioner of public accounts in the House of Commons. In 1689 Britain entered the “war of King William” which was a burden for many gentry (Whigs or Tories. Robert Harley became famous in the parliament as a critic of the war and corruption in the army. In 1693 the Whig leaders headed the ministry and continued the war. Their policy divided the Whigs party in two factions: “Court Whigs” and “Country Whigs”. Robert Harley and his supporters became “Country Whigs”, and they criticized the “Court Whigs”. By 1700 Robert Harley joined the Tory party. The article also describes the evolution of historiography of Harley‘s policy. Victorian historians have called the Prime Minister a “stupid person”. The same opinion was repeated by Russian historians of the 19th century. But in the 20th century the assessment of Robert Harley’s activity was changed by the works of K. Feiling, G. Holmes, B.W. Hill and other historians. Soviet historians (for example M.A. Barg also called R.Harley a “mediocre politician”, but modern Russian historians (L.I. Ivonina, T.L. Labutina and others consider him a “clever statesman” and a “master of political intrigues and parliamentary diplomacy”.

Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First ...

African Journals Online (AJOL)

Tahir M. Malla

2015-07-14

/licenses/by-nc-nd/4.0/). 1. Introduction. Roberts SC phocomelia syndrome is an autosomal recessive developmental disorder characterized by pre and postnatal growth retardation, microcephaly, craniofacial anomalies,.

Roberts-SC phocomelia syndrome.

Science.gov (United States)

Maheshwari, A; Kumar, P; Dutta, S; Narang, A

2001-06-01

A severely growth retarded baby was born at 38 weeks gestation. He had multiple craniofacial anomalies, microbrachycephaly, phocomelia in the upper limbs and renal cysts visible on ultrasound. He died of recurrent apneas. The autopsy showed left sided multicystic dysplastic kidney and absence of one testis. Cytogenetic studies did not reveal any abnormality. The phenotypic features match those described in the Roberts-SC phocomelia syndrome. A literature review revealed that 50% of these patients have chromosomal defects and antenatal detection is possible on ultrasound and by chromosome analysis of the amniocytes.

[Sir Geoffrey Keynes 1887-1982. Surgical pioneer, medical historian, humanist].

Science.gov (United States)

Bergljung, Lars

2005-01-01

Sir Geoffrey Keynes (1887 - 1982), was a pioneer in the surgery of breast cancer and thymic deseases, n.b. in patients suffering from myastenia gravis. He strongly disapproved of the longstanding dogma of so called radical mastectomy in breast cancer, and advocated a more limited surgical approach, followed by radiation therapy. This was done more than fifty years before breastconserving surgery has become the therapy of choice and against considerable opposition from the surgical establishment of his days. He also became a pioneer in the surgical treatment of myastenia gravis by thymectomy, at a time when there was no real understanding of the pathophysiology of the disease and when considerable controversy existed as to the importance or non importance of concomitant tumour formation in the thymus. Besides being a busy surgeon Sir Geoffrey was a medical historian, writing the biography of among others William Harvey, a bibliographer with a special interest in the poet and artist William Blake and a bibliophil with a large book collection of great value to medical history.

Embracing the Humanistic Vision: Recurrent Themes in Peter Roberts' Recent Writings

Science.gov (United States)

Reveley, James

2018-01-01

Running like a leitmotif through Peter Roberts' recently published philosophico-educational writings there is a humanistic thread, which this article picks out. In order to ascertain the quality of this humanism, Roberts is positioned in relation to a pair of extant humanisms: radical and integral. Points of comparability and contrast are…

PALEODRAINAGES OF THE EASTERN SAHARA - THE RADAR RIVERS REVISITED (SIR - A/B IMPLICATIONS FOR A MID - TERTIARY TRANS - AFRICAN DRAINAGE SYSTEM).

Science.gov (United States)

McCauley, John F.; Breed, Carlos S.; Schaber, Gerald G.; McHugh, William P.; Issawi, Bahay; Haynes, C. Vance; Grolier, Maurice J.; El Kilani, Ali

1986-01-01

A complex history of Cenozoic fluvial activity in the presently hyperarid eastern Sahara is inferred from Shuttle Imaging Radar (SIR) data and postflight field investigations in southwest Egypt and northwest Sudan. SIR images were coregistered with Landsat and existing maps as a guide to exploration of the buried paleodrainages (radar rivers) first discovered by SIR-A. Field observations explain the radar responses of three types of radar rivers: RR-1, RR-2, and RR-3. A generalized model of the radar rivers, based on field studies and regional geologic relations, shows apparent changes in river regimen since the large valleys were established during the late Paleogene-early Neogene eras. SIR-based mapping of these paleodrainages, although incomplete, reveals missing links in an area once thought to be devoid of master streams.

Two autographs: Cecile Dewitt and Robert Hawking (for Steven Hawking)

Science.gov (United States)

Gaina, Alex

2007-12-01

Two autographs given to author by professor Cecile Dewitt and Robert Hawking (the son of Steven Hawking for his father) in 1987 during the Quantum Gravity Seminar in Moscow are presented. The first was given during a visit to Physical Institute of the Academy of sciences of the USSR, where a seminar held in the Theoretical department. the second was given during a lunch with Steven Hawking, Andrei Linde and Robert Hawking at the 2-nd floor of the Conference floor.

Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

Energy Technology Data Exchange (ETDEWEB)

Samat, N. A.; Ma' arof, S. H. Mohd Imam [Department of Mathematics, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjung Malim, Perak (Malaysia)

2014-12-04

This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

International Nuclear Information System (INIS)

Samat, N. A.; Ma'arof, S. H. Mohd Imam

2014-01-01

This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases

Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

Science.gov (United States)

Samat, N. A.; Ma'arof, S. H. Mohd Imam

2014-12-01

This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

Robert Knox, transcendentální anatomie a imaginace rasové války / Robert Knox, transcendental anatomy and imagination of racial war

Directory of Open Access Journals (Sweden)

Ivo Budil

2016-12-01

Full Text Available The main aim of the study is to emphasize the role and contribution of the Scottish physician and surgeon Robert Knox to the emergence and expansion of modern racial thinking and the concept of a racial war which became later influential as a result of the works of representatives of Social Darwinism. The main ideas outlined in the book The Races of Men: A Philosophical Enquiry into the Influence of Race over the Destinies of Nations, published by Robert Knox in 1850, will be analyzed in the historical and intellectual context of transcendental anatomy and Eurasian revolution.

Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First report from Kashmir

Directory of Open Access Journals (Sweden)

Tahir M. Malla

2016-01-01

Full Text Available There are several syndromes in which specific mitotic chromosomal abnormalities can be seen, like premature centromere separation, premature (sister chromatid separation, and somatic aneuploidies. Identifications of such specific cytogenetic findings can be the key factor that leads towards the diagnosis of syndromes like Roberts SC phocomelia. The case presented here as Roberts SC phocomelia syndrome was identified as a child with multiple congenital anomalies and dysmorphic features. Conventional cytogenetic analysis of the case revealed premature sister chromatid separation. The premature centromeric separation was also confirmed by C banding analysis of the child. It is the first and the only case of Roberts SC phocomelia diagnosed from this part of the world. The present case report emphasizes the importance of conventional cytogenetics in the diagnosis of such syndromes.

On the Shoulders of Sir Isaac Newton and Arthur Storer

Science.gov (United States)

Martin, Helen E.; Evans-Gondo, Bonita

2013-01-01

Helen E. Martin, the author of this article, is a retired National Board Certified Teacher who has been researching Sir Isaac Newton's unpublished manuscripts for over three decades. While researching the work of Newton, a teacher she was mentoring asked for some hands-on activities to study planetary motion. The description of the activity…

[Sir Harold Ridley--the creator of modern cataract surgery].

Science.gov (United States)

Obuchowska, Iwona; Mariak, Zofia

2005-01-01

In February 2000, the worldwide ophthalmology community celebrated the 50th anniversary of one of the twentieth century's most important innovations in eye care--the implantation of the first intraocular lens after cataract extraction by Sir Harold Ridley. It was the initiation of a golden age for the development of ophthalmology, especially cataract surgery. In our paper we would like to remember this outstanding English ophthalmologist and his great invention.

Sir Peter Medawar: science, creativity and the popularization of Karl Popper

Science.gov (United States)

Calver, Neil

2013-01-01

Sir Peter Medawar was respected by scientists and literati alike. It was perhaps not surprising, then, that he would choose to involve himself in the ‘two cultures’ debate of 1959 and beyond. The focus of his intervention was the philosophy of Sir Karl Popper. However, Medawar's Popper was not the guru of falsification familiar from philosophy textbooks. Medawar's distinctive interpretation of Popper treated him instead as the source of insights into the role of creativity and imagination in scientific inquiry. This paper traces the context for Medawar's adoption of Popperian philosophy, together with its application before the debate. It then examines, within the context of the debate itself, the way in which Medawar attempted to reconcile scientific inquiry with literary practice. Medawar became increasingly convinced that not only was induction epistemologically unsound, but it was also damaging to the public role of the scientist. His construction of Popperianism would, he envisaged, provide a worthy alternative for scientists’ self-image.

Sir James Paget: Paget's disease of the nipple, Paget's disease of bone.

Science.gov (United States)

Ellis, Harold

2013-04-01

Sir James Paget was one of the 'great' Victorians. Eminent as a surgeon, pathologist and teacher, his nobility of character and application to his work made him a leader in his profession in that age of great men.

THANK GOD FOR BOBBY: ROBERT KENNEDY AND THE CUBAN MISSILE CRISIS

Science.gov (United States)

2017-06-01

nomination and later confirmation of Robert Kennedy as United States Attorney General. The second was the failure of the Bay of Pigs operation in...Cuba. In nominating his brother, the President defied popular opinion and made a decision that would prove integral to his presidency. Although...and in place prior to the discovery of Soviet missiles in Cuba. Together, these two events gave Robert Kennedy a position from which to advise

Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First report from Kashmir

OpenAIRE

Tahir M. Malla; Arshad A. Pandith; Fayaz A. Dar; Mahrukh H. Zargar

2016-01-01

There are several syndromes in which specific mitotic chromosomal abnormalities can be seen, like premature centromere separation, premature (sister) chromatid separation, and somatic aneuploidies. Identifications of such specific cytogenetic findings can be the key factor that leads towards the diagnosis of syndromes like Roberts SC phocomelia. The case presented here as Roberts SC phocomelia syndrome was identified as a child with multiple congenital anomalies and dysmorphic features. Conve...

Roberts-SC syndrome, a rare syndrome and cleft palate repair

Directory of Open Access Journals (Sweden)

Murthy Jyotsna

2008-01-01

Full Text Available Roberts SC syndrome is a rare syndrome with only 17 previously recognized patients reported in medical literature. The syndrome is characterized by multiple malformations, particularly, symmetrical limb reduction, craniofacial anomalies such as bilateral cleft lip and palate, micrognathia, and severe growth and mental retardation. Our patient, a young child of five years having Roberts-SC, was successfully operated for cleft palate under general anesthesia. The main features of the syndrome and the technical problems of anesthesia and surgery are discussed in this report.

A Possible Source For Sir Thomas More’s ‘Mountainish Inhumanity’

NARCIS (Netherlands)

Steenbergh, Kristine

2017-01-01

Shakespeare’s authorship of a scene in Sir Thomas More has been established as highly probable on the basis of an analysis of the handwriting, vocabulary, and collocations stylistics. His addition to the play was long believed to have been written soon after publication of the original play, in

Sir Victor Horsley (1857-1916): pioneer of neurological surgery.

Science.gov (United States)

Tan, Tze-Ching; Black, Peter McL

2002-03-01

Immortalized in surgical history for the introduction of "antiseptic wax," Sir Victor Horsley played a pivotal role in shaping the face of standard neurosurgical practice. His contributions include the first laminectomy for spinal neoplasm, the first carotid ligation for cerebral aneurysm, the curved skin flap, the transcranial approach to the pituitary gland, intradural division of the trigeminal nerve root for trigeminal neuralgia, and surface marking of the cerebral cortex. A tireless scientist, he was a significant player in discovering the cure for myxedema, the eradication of rabies from England, and the invention of the Horsley-Clarke stereotactic frame. As a pathologist, Horsley performed research on bacteria and edema and founded the Journal of Pathology. Horsley's kindness, humility, and generous spirit endeared him to patients, colleagues, and students. Born to privilege, he was nonetheless dedicated to improving the lot of the common man and directed his efforts toward the suffrage of women, medical reform, and free health care for the working class. Knighted in 1902 for his many contributions to medicine, Sir Victor met an untimely death during World War I from heat stroke at the age of 59. An iconoclast of keen intellect, unlimited energy, and consummate skill, his life and work justify his epitaph as a "pioneer of neurological surgery."

Sir William Osler's speech at Troy: a Trojan horse?

Science.gov (United States)

Moran, Michael E

2012-01-01

Troy, New York, is a city of 55,000 people in upstate New York located along the Hudson River. A city of surprisingly rich cultural heritage, it was the home of New York state's first hospital outside New York City. The 50th anniversary celebration of Troy's hospital brought William Osler to the city as the keynote speaker. This speech, delivered on November 28, 1900, is one of Sir William's less well known addresses. Osler began his comments with Sir Thomas More's Utopia and talked at length about the hospital, its obligations, the influences it has upon the community, and the role of physicians and surgeons. He broached one of his old saws, the salary of attending physicians and their needed role in hospital management. His words were published in the diamond jubilee's records, but the hospital did not outlive its prominent guest professor, and it closed its doors in 1914. Just like the great historical city of Troy, New York's own Troy was on the brink of decline, and its hospital would be the first fatality. Therefore, it is almost prescient that the words of Osler, taken into historical context juxtaposed against the socioeconomic forces at work, are akin to the Greek's offering of a wooden edifice to end the Trojan War.

American Prometheus. The Triumph and Tragedy of J. Robert Oppenheimer. Biography; J. Robert Oppenheimer. Die Biographie

Energy Technology Data Exchange (ETDEWEB)

Bird, Kai; Sherwin, Martin J.

2009-07-01

A definitive portrait of legendary scientist J. Robert Oppenheimer, the ''father'' of the atomic bomb, discusses his seminal role in the twentieth-century scientific world, as well as his lesser-known roles as family man, supposed communist, and head of Princeton's Institute for Advanced Studies. ''American Prometheus'' is a rich evocation of America in mid-century and a compelling portrait of scientist J. Robert Oppenheimer, a man shaped by its major events--the Depression, World War II, and the Cold War. (orig.) [German] J. Robert Oppenheimer (1904-1967), der ''Vater der Atombombe'', zaehlt zu den schillerndsten Figuren der juengeren Zeitgeschichte. Fuer ihre glaenzende Biographie des ''amerikanischen Prometheus'' erhielten der Journalist Kai Bird und der Historiker Martin J. Sherwin den Pulitzer-Preis. Exemplarisch lassen sie das Drama eines Forschers lebendig werden, der sich zwischen Erkenntnisdrang und ethischer Verantwortung entscheiden muss. Oppenheimer leitete das streng geheime Manhattan-Projekt in der Wueste von New Mexico, wo am 16. Juli 1945 die erste Atombombe gezuendet wurde. Kurz darauf starben in Hiroshima und Nagasaki mehr als 200 000 Menschen durch die neue ''Wunderwaffe'' - die Menschheit war ins Atomzeitalter eingetreten. Erschuettert von der Zerstoerungskraft seiner Schoepfung, engagierte sich Oppenheimer fortan gegen den Einsatz nuklearer Waffen. Das machte ihn im Amerika der McCarthy-Aera verdaechtig. Er geriet ins Visier des FBI, wurde als Spion der Sowjetunion verleumdet und musste den Staatsdienst quittieren. Sein Privatleben wurde an die Oeffentlichkeit gezerrt, seine Wohnung verwanzt, sein Telefon abgehoert. Erst 1963 rehabilitierte ihn Praesident Kennedy. Ueber dreissig Jahre hinweg haben die Autoren Interviews mit Oppenheimers Angehoerigen, Freunden und Kollegen gefuehrt, FBI-Akten gesichtet, Tonbaender von Reden und Verhoeren

Sir John and Lady Rita Cornforth: a distinguished chemical partnership.

Science.gov (United States)

Purchase, Rupert; Hanson, James R

2015-01-01

This review describes the life of Sir John Cornforth AC CBE FRS, who was awarded the Nobel Prize for Chemistry in 1975. It covers his early life in Australia, his work in Oxford, the National Institute for Medical Research, the Milstead Laboratory of Chemical Enzymology and the University of Sussex, together with the contributions made by his wife, Lady Rita Cornforth.

Stability and bifurcation analysis in a delayed SIR model

International Nuclear Information System (INIS)

Jiang Zhichao; Wei Junjie

2008-01-01

In this paper, a time-delayed SIR model with a nonlinear incidence rate is considered. The existence of Hopf bifurcations at the endemic equilibrium is established by analyzing the distribution of the characteristic values. A explicit algorithm for determining the direction of the Hopf bifurcation and the stability of the bifurcating periodic solutions are derived by using the normal form and the center manifold theory. Numerical simulations to support the analytical conclusions are carried out

The use of multifrequency and polarimetric SIR-C/X-SAR data in geologic studies of Bir Safsaf, Egypt

Science.gov (United States)

Schaber, G.G.; McCauley, J.F.; Breed, C.S.

1997-01-01

Bir Safsaf, within the hyperarid 'core' of the Sahara in the Western Desert of Egypt, was recognized following the SIR-A and SIR-B missions in the 1980s as one of the key localities in northeast Africa, where penetration of dry sand by radar signals delineates previously unknown, sand-buried paleodrainage valleys ('radar-rivers') of middle Tertiary to Quaternary age. The Bir Safsaf area was targeted as a focal point for further research in sand penetration and geologic mapping using the multifrequency and polarimetric SIR-C/X-SAR sensors. Analysis of the SIR-C/X-SAR data from Bir Safsaf provides important new information on the roles of multiple SAR frequency and polarimetry in portraying specific types of geologic units, materials, and structures mostly hidden from view on the ground and on Landsat TM images by a relatively thin, but extensive blanket of blow sand. Basement rock units (granitoids and gneisses) and the fractures associated with them at Bir Safsaf are shown here for the first time to be clearly delineated using C- and L-band SAR images. The detectability of most geologic features is dependent primarily on radar frequency, as shown for wind erosion patterns in bedrock at X-band (3 cm wavelength), and for geologic units and sand and clay-filled fractures in weathered crystal-line basement rocks at C-band (6 cm) and L-band (24 cm). By contrast, Quaternary paleodrainage channels are detectable at all three radar frequencies owing, among other things, to an usually thin cover of blow sand. The SIR-C/X-SAR data investigated to date enable us to make specific recommendations about the utility of certain radar sensor configurations for geologic and paleoenvironmental reconnaissance in desert regions.Analysis of the shuttle imaging radar-C/X-synthetic aperture radar (SIR-C/X-SAR) data from Bir Safsaf provides important new information on the roles of multiple SAR frequency and polarimetry in portraying specific types of geologic units, materials, and

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

DEFF Research Database (Denmark)

Lombard, David B; Alt, Frederick W; Cheng, Hwei-Ling

2007-01-01

Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here, we investigate the localization and function of SIRT3 in vivo. We show that endogenous mouse SIRT3 is a solubl...

Robert Aymar, Director-General of CERN

CERN Document Server

Patrice Loïez

2003-01-01

Robert Aymar, photographed in 2003 before taking his position as Director-General at CERN, succeeding Luciano Maiani in 2004. At this time, Aymar was director of the International Thermonuclear Experimental Reactor (ITER) although he had already been involved with developments at CERN, chairing the External Review Committee, set up in 2001 in response to the increased cost of the LHC.

Sir Rudolf Peierls Selected private and scientific correspondence

CERN Document Server

Lee, Sabine

2007-01-01

This edition of the private and scientific correspondence of Sir Rudolf Peierls gives a unique insight into the life and work of one of the greatest theoretical physicists of the 20th century. Rudolf Peierls' scientific work contributed to the early developments in quantum mechanics, and he is well known and much appreciated for his contributions to various disciplines, including solid state physics, nuclear physics, and particle physics. As an enthusiastic and devoted teacher, he passed on his knowledge and understanding and inspired the work of collaborators and students alike. As an effecti

Numerical Methods in Atmospheric and Oceanic Modelling: The Andre J. Robert Memorial Volume

Science.gov (United States)

Rosmond, Tom

Most people, even including some in the scientific community, do not realize how much the weather forecasts they use to guide the activities of their daily lives depend on very complex mathematics and numerical methods that are the basis of modern numerical weather prediction (NWP). André Robert (1929-1993), to whom Numerical Methods in Atmospheric and Oceanic Modelling is dedicated, had a career that contributed greatly to the growth of NWP and the role that the atmospheric computer models of NWP play in our society. There are probably no NWP models running anywhere in the world today that do not use numerical methods introduced by Robert, and those of us who work with and use these models everyday are indebted to him.The first two chapters of the volume are chronicles of Robert's life and career. The first is a 1987 interview by Harold Ritchie, one of Robert's many proteges and colleagues at the Canadian Atmospheric Environment Service. The interview traces Robert's life from his birth in New York to French Canadian parents, to his emigration to Quebec at an early age, his education and early employment, and his rise in stature as one of the preeminent research meteorologists of our time. An amusing anecdote he relates is his impression of weather forecasts while he was considering his first job as a meteorologist in the early 1950s. A newspaper of the time placed the weather forecast and daily horoscope side by side, and Robert regarded each to have a similar scientific basis. Thankfully he soon realized there was a difference between the two, and his subsequent career certainly confirmed the distinction.

Robert Klopstock and Franz Kafka--the friends from Tatranské Matliare (the High Tatras).

Science.gov (United States)

Mydlík, M; Derzsiová, K

2007-01-01

The paper summarises the accessible literature on the life and work of well-known American lung surgeon, Professor Dr. Med. Robert Klopstock, who was in the years 1920-1924 a friend Franz Kafka. Professor Klopstock was of Hungarian origin and he got acquainted with Franz Kafka at the end of the year 1920 in Tatranské Matliare (The High Tatras). They were both patients treated for lung tuberculosis. They became close friends and their mutual correspondence shows their real friendship. Robert Klopstock was present at Franz Kafka's death-bed on June 3, 1924 in Kierling, near Klosterneuburg, not far from Vienna. Robert Klopstock studied at Medical Faculties of the Universities in Budapest, Prague, Kiel and Berlin. After his graduation in 1933 in Berlin, he worked as a lung surgeon at various surgical clinics and departments in Budapest and Berlin. In 1936 Robert Klopstock together with his wife visited the High Tatras and Tatranské Matliare. In 1937 Robert Klopstock with his wife Gizela, a writer and a translator, who translated the first chapters of Franz Kafka's novel "Trial" into Hungarian language, went to United States of America. During his stay in U.S.A. Dr. Med. Robert Klopstock was very active as a lung surgeon and a scientist. He published 64 specialized scientific papers, mostly in American medical journals. He became Professor of Lung Surgery at Downstate Medical Centre in New York-Brooklyn. He died on June 15, 1972 in New York.

Robert Aymar receives one of the highest Finnish distinctions

CERN Multimedia

2008-01-01

On 9 December 2008 Robert Aymar, CERN Director-General, was awarded the decoration of Commander, first class, of the Order of the Lion of Finland by the President of the Republic of Finland. This decoration, one of the highest of Finland, was presented in a ceremony by the Ambassador Hannu Himanen, Permanent Representative of Finland to the UN and other international organisations in Geneva. Robert Aymar was honoured for his service to CERN, the LHC, his role in the cooperation between Finland and CERN, as well as his contribution to science in general. In his speech the ambassador underlined CERN’s efforts in the field of education, mentioning the High school teachers programme.

Robert Eisenstein joins the ATLAS collaboration at CERN

CERN Multimedia

Maximilien Brice

2002-01-01

Robert Eisenstein, former assistant director for mathematical and physical sciences (MPS) at the US National Science Foundation (NSF), has stepped down from the job to spend a year at CERN as a member of the ATLAS collaboration.

Intervjuu American Wind Symphony Orchestra dirigendi Robert Austin Boudreau'ga = Interview with Mr. Robert Austin Boudreau, director of the American Wind Symphony Orchestra / Robert Austin Boudreau ; interv. Heli Ojamaa

Index Scriptorium Estoniae

Boudreau, Robert Austin

2007-01-01

11. IV 2007. a. tehtud telefoniintervjuu Robert A. Boudreau'ga, kellele arhitekt Louis I. Kahn disainis kontserdilaevad Point Counterpoint I (valmis 1961) ja Point Counterppoint II (kavandamist alustati 1966, valmis 1975). Louis I. Kahnist, koostööst arhitektiga ja laevadest. Selgitav kaaskiri arhitekt Heli Ojamaalt. Ill.: I laeva makett, II laeva joonised ja 4 värv. fotot

Application of Homotopy Perturbation and Variational Iteration Methods to SIR Epidemic Model

DEFF Research Database (Denmark)

Ghotbi, Abdoul R.; Barari, Amin; Omidvar, M.

2011-01-01

effective strategy against childhood diseases, the development of the framework that would predict the optimal vaccine coverage level needed to prevent the spread of diseases is crucial. The SIR model is a standard compartmental model that has been used to describe many epidemiological diseases...

Sir Victor Horsley: pioneer craniopharyngioma surgeon.

Science.gov (United States)

Pascual, José M; Prieto, Ruth; Mazzarello, Paolo

2015-07-01

Sir Victor Horsley (1857-1916) is considered to be the pioneer of pituitary surgery. He is known to have performed the first surgical operation on the pituitary gland in 1889, and in 1906 he stated that he had operated on 10 patients with pituitary tumors. He did not publish the details of these procedures nor did he provide evidence of the pathology of the pituitary lesions operated on. Four of the patients underwent surgery at the National Hospital for Neurology and Neurosurgery (Queen Square, London), and the records of those cases were recently retrieved and analyzed by members of the hospital staff. The remaining cases corresponded to private operations whose records were presumably kept in Horsley's personal notebooks, most of which have been lost. In this paper, the authors have investigated the only scientific monograph providing a complete account of the pituitary surgeries that Horsley performed in his private practice, La Patologia Chirurgica dell'Ipofisi (Surgical Pathology of the Hypophysis), written in 1911 by Giovanni Verga, Italian assistant professor of anatomy at the University of Pavia. They have traced the life and work of this little-known physician who contributed to the preservation of Horsley's legacy in pituitary surgery. Within Verga's pituitary treatise, a full transcription of Horsley's notes is provided for 10 pituitary cases, including the patients' clinical symptoms, surgical techniques employed, intraoperative findings, and the outcome of surgery. The descriptions of the topographical and macroscopic features of two of the lesions correspond unmistakably to the features of craniopharyngiomas, one of the squamous-papillary type and one of the adamantinomatous type. The former lesion was found on necropsy after the patient's sudden death following a temporal osteoplastic craniectomy. Surgical removal of the lesion in the latter case, with the assumed nature of an adamantinomatous craniopharyngioma, was successful. According to the

Robert Henry Thurston: Professionalism and Engineering Education

Science.gov (United States)

Nienkamp, Paul

2016-01-01

Robert Henry Thurston is presented in this article. He provides one the most significant examples of professionalizing engineering through innovative education and promoting scientific education practices in the late nineteenth century. The son of a draftsmen and steam engine mechanic, Thurston spent his early years in Providence, Rhode Island.…

La Corte Roberts e la questione della “preghiera municipale”

Directory of Open Access Journals (Sweden)

Adelaide Madera

2017-02-01

 The Roberts Court and the “municipal prayer” Abstract: In the USA, few topics are more divisive than the government’s use of religious expressions and symbols. The Supreme Court has tried to find a balance between the Establishment Clause of the U.S. Constitution and the inclusion of religious expressions in government activities. In Town of Greece v. Galloway, the Roberts Court upheld a town’s practice of opening board meetings with prayers from invited speakers. The essay critically examines the various opinions in the case, and looks at where this decision suggests the Establishment Clause doctrine is moving award.

American Prometheus. The Triumph and Tragedy of J. Robert Oppenheimer. Biography

International Nuclear Information System (INIS)

Bird, Kai; Sherwin, Martin J.

2009-01-01

A definitive portrait of legendary scientist J. Robert Oppenheimer, the ''father'' of the atomic bomb, discusses his seminal role in the twentieth-century scientific world, as well as his lesser-known roles as family man, supposed communist, and head of Princeton's Institute for Advanced Studies. ''American Prometheus'' is a rich evocation of America in mid-century and a compelling portrait of scientist J. Robert Oppenheimer, a man shaped by its major events--the Depression, World War II, and the Cold War. (orig.) [de

Robert Lawson (?1846-1896).

Science.gov (United States)

Larner, A J; Gardner-Thorpe, C

2012-04-01

Various descriptions of what would now be called Korsakoff Syndrome may be found in the medical literature predating the eponymous reports of Sergei Korsakoff (1854-1900) that date from 1887 onwards. Of these, it has been stated that the "most promising account" (Draaisma in Disturbances of the mind 163-164, 2009) may be that of Dr. Robert Lawson, published in 1878 in the journal Brain in its inaugural year of publication (Lawson in Brain 1:182-194, 1878). As Lawson is likely to be an unfamiliar name to most neurologists, and does not appear in the Oxford Dictionary of National Biography, we offer this brief account of his life and work.

A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability.

Directory of Open Access Journals (Sweden)

Tânia Reis

2010-11-01

Full Text Available Obesity has a strong genetic component, but few of the genes that predispose to obesity are known. Genetic screens in invertebrates have the potential to identify genes and pathways that regulate the levels of stored fat, many of which are likely to be conserved in humans. To facilitate such screens, we have developed a simple buoyancy-based screening method for identifying mutant Drosophila larvae with increased levels of stored fat. Using this approach, we have identified 66 genes that when mutated increase organismal fat levels. Among these was a sirtuin family member, Sir2. Sirtuins regulate the storage and metabolism of carbohydrates and lipids by deacetylating key regulatory proteins. However, since mammalian sirtuins function in many tissues in different ways, it has been difficult to define their role in energy homeostasis accurately under normal feeding conditions. We show that knockdown of Sir2 in the larval fat body results in increased fat levels. Moreover, using genetic mosaics, we demonstrate that Sir2 restricts fat accumulation in individual cells of the fat body in a cell-autonomous manner. Consistent with this function, changes in the expression of metabolic enzymes in Sir2 mutants point to a shift away from catabolism. Surprisingly, although Sir2 is typically upregulated under conditions of starvation, Sir2 mutant larvae survive better than wild type under conditions of amino-acid starvation as long as sugars are provided. Our findings point to a Sir2-mediated pathway that activates a catabolic response to amino-acid starvation irrespective of the sugar content of the diet.

75 FR 32740 - Action Affecting Export Privileges; Aaron Robert Henderson and Valhalla Tactical Supply

Science.gov (United States)

2010-06-09

... Robert Henderson and Valhalla Tactical Supply In the Matter of: Aaron Robert Henderson, 740 Jessie St., North Liberty, IA 52317. Respondent and Valhalla Tactical Supply, 740 Jessie Street, North Liberty, IA... is the owner, operator and president of Valhalla Tactical Supply (``Valhalla''), Valhalla is related...

Robert Rodrigueze verejugadega õudusfilm tuleb Igavuse planeedilt / Mihkel Raud

Index Scriptorium Estoniae

Raud, Mihkel, 1969-

2007-01-01

Filmiprojekt "Grindhouse" koosneb Robert Rodrigueze retroõudukast "Grindhouse : Õuduste planeet" ("Planet Terror") ja Quentin Tarantino 70-ndatest inspireeritud õudusfilmist "Surmakindel" ("Death Proof") : Ameerika Ühendriigid 2007. R. Rodrigueze filmist

Astronaut Robert L. Crippen prepares for underwater training session

Science.gov (United States)

1983-01-01

Astronaut Robert L. Crippen, STS-7 crew commander, adjusts his extravehicular mobility unit's (EMU) gloves prior to donning his helmet for a training session in the weightless environment test facility (WETF).

May thrombopoietin be a useful marker of sepsis severity assessment in patients with SIRS entering the emergency department?

Science.gov (United States)

Segre, Elisabetta; Pigozzi, Luca; Lison, Davide; Pivetta, Emanuele; Bosco, Ornella; Vizio, Barbara; Suppo, Umberto; Turvani, Fabrizio; Morello, Fulvio; Battista, Stefania; Moiraghi, Corrado; Montrucchio, Giuseppe; Lupia, Enrico

2014-10-01

Thrombopoietin (TPO), a growth factor primarily involved in regulating thrombopoiesis, has been recently implicated in the pathogenesis of sepsis. TPO levels are, indeed, greatly increased in patients with sepsis compared to control subjects, and correlate with sepsis severity. The aim of this study was to evaluate TPO as predictive biomarker of sepsis and of sepsis severity in patients entering the emergency department (ED) with systemic inflammatory response syndrome (SIRS). This was a prospective observational study. Ours is a sub-study of the 'Need-speed trial', a multi-center observational study involving six Italian centers affiliated to the GREAT Italian Network. TPO was measured by ELISA. We enrolled 13 patients with SIRS (6 with acute pancreatitis, 3 with acute heart failure, 1 with pulmonary embolism, and 3 with allergic reactions), and 40 patients with sepsis, eight of whom had severe sepsis and three septic shock. TPO was significantly higher in patients with sepsis than with SIRS. In addition, TPO was higher in patients with severe sepsis than with sepsis, and in patients with septic shock than with severe sepsis, although these differences did not reach the statistical significance. Our preliminary results suggest that TPO may have the potential to be considered a promising early biomarker for both the diagnosis of sepsis and the assessment of sepsis severity in patients with SIRS entering the ED.

Das Fortbildungsangebot der Bibliothek des Robert Koch-Instituts: Dienstleistung im Publikationsprozess

Directory of Open Access Journals (Sweden)

Senst, Henriette

2013-12-01

Full Text Available [english] Robert Koch-Institute’s scientists are supported during the publishing process in different ways. Relating to frequently asked questions the library offers trainings, which are integrated in the training program of the institute.How does a good literature research work? How do I manage my literature and how do I cite correctly? What do I have to consider during the publishing process? These and other questions are answered in trainings on literature research, managing bibliographies with EndNote and “Scientific Publishing in the Robert Koch-Institute” which take place regularly.

Expanding the mutation and clinical spectrum of Roberts syndrome.

Science.gov (United States)

Afifi, Hanan H; Abdel-Salam, Ghada M H; Eid, Maha M; Tosson, Angie M S; Shousha, Wafaa Gh; Abdel Azeem, Amira A; Farag, Mona K; Mehrez, Mennat I; Gaber, Khaled R

2016-07-01

Roberts syndrome and SC phocomelia syndrome are rare autosomal recessive genetic disorders representing the extremes of the spectrum of severity of the same condition, caused by mutations in ESCO2 gene. We report three new patients with Roberts syndrome from three unrelated consanguineous Egyptian families. All patients presented with growth retardation, mesomelic shortening of the limbs more in the upper than in the lower limbs and microcephaly. Patients were subjected to clinical, cytogenetic and radiologic examinations. Cytogenetic analysis showed the characteristic premature separation of centromeres and puffing of heterochromatic regions. Further, sequencing of the ESCO2 gene identified a novel mutation c.244_245dupCT (p.T83Pfs*20) in one family besides two previously reported mutations c.760_761insA (p.T254Nfs*27) and c.764_765delTT (p.F255Cfs*25). All mutations were in homozygous state, in exon 3. The severity of the mesomelic shortening of the limbs and craniofacial anomalies showed variability among patients. Interestingly, patient 1 had abnormal skin hypopigmentation. Serial fetal ultrasound examinations and measurements of long bones diagnosed two affected fetuses in two of the studied families. A literature review and case comparison was performed. In conclusion, we report a novel ESCO2 mutation and expand the clinical spectrum of Roberts syndrome. © 2015 Japanese Teratology Society.

Aitab hädaldamisest / Robert Antropov

Index Scriptorium Estoniae

Antropov, Robert, 1965-

2006-01-01

Endine politseijuht on seisukohal, et politseinike ja päästjate nappuses ei saa süüdistada ainult väikseid palku, küsimus on valikutes: kuidas ja millesse ressursse paigutada. Kalle Laanet ja Raivo Aeg vastavad küsimusele, mis on nende haldusalas konkreetselt kavas, et politsei saaks täita oma tegevusprioriteeti 100% ja tagada sisejulgeoleku. Vt. ka Robert Antropovi kommentaari 7. aug. Eesti Päevaleht lk. 2

Agro-transformation and evaluation of resistance to Phytophthora infestansin Solanum tuberosumL. variety Désirée

Directory of Open Access Journals (Sweden)

Jeanette Orbegozo

2014-03-01

Full Text Available The Oomycete Phytophthora infestans (Mont. de Bary, the causal agent of the disease known as late blight, is primarily responsible for the decreased in production performance and potato crops worldwide. The integration of the complete Rgenes sequences in the potato genome using Agro-transformation appears an alternative to be considered in the fight against this pathogen. The Rpi-blb2 gene (Rgene from the wild species Solanum bulbocastanumDunal shows a broad resistance to isolates ofP. infestans,making it an important candidate for plant breeding studies. This paper reports the integration of the Rpi-blb2gene into potato var. Désirée genome by Agrobacterium tumefaciens- mediated transformation system, the molecular characterization of 29 events transformed and whole plant infection with isolate POX67 of P. infestansfrom Peru. Désirée events [Rpi-blb2] 4 and Désirée [Rpi-blb2] 30, showed a substantial resistance to P. infestansinfection confirming complete transfer of the Rpi-blb2gene from a wild species to a cultivated species by genetic transformation.

Discovering Moral Engagement: An Interview with Robert Coles.

Science.gov (United States)

Scott, Bradwell D.

1995-01-01

Educator Robert Coles argues that there is a need for a basis on which to teach and cultivate moral awareness in parents and children. Active parenting requires both inner-directed and outer-directed focuses to take advantage of the everyday events through which morality is developed. (SLD)

Transitioning Natures: Robert Schuller’s Garden Grove Experiment

Directory of Open Access Journals (Sweden)

Antonio Petrov

2016-09-01

Full Text Available Through the lens of Evangelist Reverend Robert H. Schuller’s Garden Grove drive-in walk-in church, this paper aims to exemplify how his architecture has transcended existing geographies that have long been anchored by the epistemology of what can be referred to as traditional “religious” architecture. This paper examines how Schuller instrumentalized broader imbrications of political contexts to change or manipulate the traditional religious subject. It also presents how Robert Schuller’s Garden Grove experiment reconceptualized “territory” as an evolving ideological dimension; not as a trajectory, or as transitory space, but as inhabitable third nature. My analysis challenges established readings of religious architecture as being interiorized manifestations. To do so, it poses the following questions: how does this meta-geographical dimension shed new light on questions of (traditional architectural aesthetics in Protestant architecture? What spaces and politics does it produce? Does the third nature have a history of its own?

Introduction : The scope of Robert Buijtenhuis' work

NARCIS (Netherlands)

Binsbergen, van W.M.J.; Konings, P.J.J.; Hesseling, G.S.C.M.; Konings, P.J.J.; Binsbergen, van W.M.J.; Hesseling, G.S.C.M.

2000-01-01

Cet ouvrage présente onze contributions rédigées par des africanistes qui ont collaboré étroitement avec l'anthropologue politique néerlandais Robert Buijtenhuijs et ont été influencés par ses travaux et sa personnalité. Le livre est un hommage à un auteur qui a été productif dans beaucoup de

Sir William Mitchell (1925-2002)

CERN Multimedia

2002-01-01

Sir William (Bill) Mitchell, former President of the CERN Council, died on 30th October 2002 at the age of 77. Mitchell was professor of Physics at Oxford University from 1978 to 1989, having previously been Professor of Physics, Dean of Science and Deputy Vice-Chancellor at Reading University. From 1985 to 1990 he was Chairman of the UK's Science and Engineering Research Council (SERC), which at the time was the funding agency for the UK's participation in the CERN programme. As Chairman, Mitchell was one of the UK representatives on the CERN Council, and in 1991 he was elected President, a position he held for three years. This was a difficult period for CERN. Financial problems were being faced in many member states, notably in Germany as a result of unification. This led to calls for reductions in the CERN budget and, more significantly, to requests for delays in consderation of future programmes. On the other hand for the future of CERN and the progress of elementary particle physics, it was necessary...

Robert Sternberg's mental self-government theory and its ...

African Journals Online (AJOL)

Robert Sternberg's mental self-government theory and its contribution to our understanding of first-year distance learners' multiple thinking style preferences. ... This intelligence (the perception we have of information systems and the way we manage them) will influence the way we think and learn. This also applies to ...

The optimal dynamic immunization under a controlled heterogeneous node-based SIRS model

Science.gov (United States)

Yang, Lu-Xing; Draief, Moez; Yang, Xiaofan

2016-05-01

Dynamic immunizations, under which the state of the propagation network of electronic viruses can be changed by adjusting the control measures, are regarded as an alternative to static immunizations. This paper addresses the optimal dynamical immunization under the widely accepted SIRS assumption. First, based on a controlled heterogeneous node-based SIRS model, an optimal control problem capturing the optimal dynamical immunization is formulated. Second, the existence of an optimal dynamical immunization scheme is shown, and the corresponding optimality system is derived. Next, some numerical examples are given to show that an optimal immunization strategy can be worked out by numerically solving the optimality system, from which it is found that the network topology has a complex impact on the optimal immunization strategy. Finally, the difference between a payoff and the minimum payoff is estimated in terms of the deviation of the corresponding immunization strategy from the optimal immunization strategy. The proposed optimal immunization scheme is justified, because it can achieve a low level of infections at a low cost.

An SIRS model with a nonlinear incidence rate

International Nuclear Information System (INIS)

Jin Yu; Wang, Wendi; Xiao Shiwu

2007-01-01

The global dynamics of an SIRS model with a nonlinear incidence rate is investigated. We establish a threshold for a disease to be extinct or endemic, analyze the existence and asymptotic stability of equilibria, and verify the existence of bistable states, i.e., a stable disease free equilibrium and a stable endemic equilibrium or a stable limit cycle. In particular, we find that the model admits stability switches as a parameter changes. We also investigate the backward bifurcation, the Hopf bifurcation and Bogdanov-Takens bifurcation and obtain the Hopf bifurcation criteria and Bogdanov-Takens bifurcation curves, which are important for making strategies for controlling a disease

Ravel and Robert-Houdin, Magicians

DEFF Research Database (Denmark)

Fillerup, Jessie

2013-01-01

,” which resonates with accounts of Ravel's Baudelairean artifice in life and work. For magicians, “illusion” was interchangeable with “effect.” The word “effect” recurs in both Ravel's writings and “The Philosophy of Composition,” a theoretical-didactic essay by Edgar Allan Poe, whom Ravel cited as one...... of his most important artistic influences. Ravel's appreciation of Poe has a much richer grain than has been imagined, extending beyond compositional artisanship to include literary and theatrical stratagems. Robert-Houdin, who started his career as a clockmaker, featured automata at his Soiréé...

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.

Science.gov (United States)

Ondracek, Caitlin R; Frappier, Vincent; Ringel, Alison E; Wolberger, Cynthia; Guarente, Leonard

2017-03-07

Sirtuin enzymes depend on NAD + to catalyze protein deacetylation. Therefore, the lowering of NAD + during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic screen to identify two mutations in the catalytic domain of yeast Sir2 that allow the enzyme to function in an NAD + -depleted environment. These mutant enzymes give rise to a significant increase of yeast replicative lifespan and increase deacetylation by the Sir2 ortholog, SIRT1, in mammalian cells. Our data suggest that these mutations increase the stability of the conserved catalytic sirtuin domain, thereby increasing the catalytic efficiency of the mutant enzymes. Our approach to identifying sirtuin mutants that permit function in NAD + -limited environments may inform the design of small molecules that can maintain sirtuin activity in aging organisms. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination

OpenAIRE

Miao, Anqi; Zhang, Jian; Zhang, Tongqian; Pradeep, B. G. Sampath Aruna

2017-01-01

A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control.

Quality of life research: interview with Professor Robert Cummins

Directory of Open Access Journals (Sweden)

Robert Cummins

2013-09-01

Full Text Available Health-related quality of life (HRQOL is a fundamental concept in the field of clinical medicine and has been studied during the last years by psychologists, sociologists, economists and managers. The concept of HRQOL includes those aspects of overall QOL that can be indicated to have an impact on patients’ health, either physical or psychological. Concerning the individuals, this incorporates physical and mental health cognitions, including sociodemographic factors, sexual functioning, fatigue, sleep disorders and functional status. One of the most eminent experts in the world in the field of QOL is Prof. Robert Cummins [Professor of Psychology at Deakin University in Australia (School of Psychology, Deakin University, 221 Burwood Highway, Victoria 3125 Melbourne, Australia. E-mail: robert.cummins@deakin.edu.au] who kindly accepted to answer our questions in the con- text of this special edition.

Robert Schuman, principal architect of the European Union

NARCIS (Netherlands)

Margriet Krijtenburg

2015-01-01

A tangible proof of the meaning and scope of human flourishing that can change not only organizations but also entire societies, is given by Robert Schuman, the French Minister of Foreign Affairs who launched the Schuman Declaration (1950) that gave birth to the EU. His leitmotiv was to be a

Bora Bora, Tahaa, and Raiatea, French Polynesia, Landsat and SIR-C Images Compared to SRTM Shaded

Science.gov (United States)

2005-01-01

Bora Bora, Tahaa, and Raiatea (top to bottom) are Polynesian Islands about 220 kilometers (135 miles) west-northwest of Tahiti in the South Pacific. Each of the islands is surrounded by a coral reef and its associated islets ('motus') that enclose a lagoon. Actually, as seen here, Tahaa and Raiatea are close enough together to share a common lagoon and reef. These islands are volcanic in origin and were built up from the sea floor by lava extrusions millions of years ago. None is now active, and all are deeply eroded. This display compares three differing 'views from space' of these islands. On the left, an image from the Landsat 7 satellite shows the islands as they might have appeared to an astronaut in orbit in 1999 (but a little sharper and with atmospheric haze suppressed). In the middle is an image created from data gathered by the third-generation Shuttle Imaging Radar (SIR-C), flown in 1994. On the right is a graphic illustrating elevation data gathered by the Shuttle Radar Topography Mission (SRTM) in 2000. Each of these images shows very different information as compared to the other two. Landsat sees clouds, which are almost always above these islands, blocking the view of the terrain. It also readily sees through shallow water down to the reefs. SIR-C sees the waves and other effects of winds upon the ocean surface. It does not look through water to see the reefs, but it clearly separates land and water. It also provides a bolder (but distorted) view of the islands' topographic patterns. With the ability of radar to see through clouds and provision of its own illumination, the SIR-C view is not limited by clouds nor their shadows. SRTM was designed to provide new information that is missing in the Landsat and SIR-C views. Specifically, SRTM created the world's first near-global, detailed elevation model. Natural topographic shading in Landsat imagery and radar topographic shadowing of SIR-C give some evidence of the shape of the ground but do not

Research Ship Robert Gordon Sproul Underway Meteorological Data, Quality Controlled

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Research Ship Robert Gordon Sproul Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and...

Patterns of Gram-stained fecal flora as a quick diagnostic marker in patients with severe SIRS.

Science.gov (United States)

Shimizu, Kentaro; Ogura, Hiroshi; Tomono, Kazunori; Tasaki, Osamu; Asahara, Takashi; Nomoto, Koji; Morotomi, Masami; Matsushima, Asako; Nakahori, Yasutaka; Yamano, Shuhei; Osuka, Akinori; Kuwagata, Yasuyuki; Sugimoto, Hisashi

2011-06-01

The gut is an important target organ of injury during critically ill conditions. Although Gram staining is a common and quick method for identifying bacteria, its clinical application has not been fully evaluated in critically ill conditions. This study's aims were to identify patterns of Gram-stained fecal flora and compare them to cultured bacterial counts and to investigate the association between the patterns and septic complications in patients with severe systemic inflammatory response syndrome (SIRS). Fifty-two patients with SIRS were included whose Gram-stained fecal flora was classified into three patterns. In a diverse pattern, large numbers of multiple kinds of bacteria completely covered the field. In a single pattern, one specific kind of bacteria or fungi predominantly covered the field. In a depleted pattern, most bacteria were diminished in the field. In the analysis of fecal flora, the numbers of total obligate anaerobes in the depleted pattern was significantly lower than those in the diverse pattern and single pattern (p Gram-stained fecal flora can be classified into three patterns and are associated with both cultured bacterial counts and clinical information. Gram-stained fecal bacteria can be used as a quick bedside diagnostic marker for severe SIRS patients.

Zombilood / Robert Kirkman ; intervjueerinud Margit Tõnson, Peeter Helme

Index Scriptorium Estoniae

Kirkman, Robert

2010-01-01

Režissöör George A. Romero kultusfilmid zombidest "Elavate surnute öö", "Surnute koidik", "Surnute päev" jpt. on inspiratsiooniks koomiksikirjutaja Robert Kirklandile. Režissöör Frank Darabont on teinud tema tuntuimast koomiksiseeriast "The Walking Dead" teleseriaali "Kõndivad surnud". Zombiteema kasvavast populaarsusest ning intervjuu koomiksikirjutajaga

Désir, besoin, dépendance : l'addiction comme (épreuve de la modernité

Directory of Open Access Journals (Sweden)

Rita Di Lorenzo

2016-04-01

Full Text Available La frontière entre la santé et la pathologie est un lieu fascinant et dangereux, au caractère poreux et riche de familiarités des deux côtés, inavouées et coûteuses. Le terme d’addiction semble s’installer précisément sur cette frontière, gagnant en étendue médiatique ce qu’il perd en précision nosographique ; ainsi, aujourd’hui, nous serions « tous addicts » – au sucre, au téléphone portable, au chocolat, au café, aux soldes, à la chirurgie esthétique, à Facebook, à l’amour, cette liste pouvant être continuée par chacun d’entre nous puisque nous avons tous fait, nous faisons et ferons tous, l’expérience de la force des (mauvaises habitudes, du désir, voire de la pulsion, de l’abus et de la dépendance. Notre société contemporaine semble stimuler cette expérience, en multipliant tant les objets addictogènes que les comportements addictifs : d’une part par le statut attribué aux biens sériels, d’autre part par la dimension pulsionnelle revendiquée dans les habitudes de consommation. Société du plaisir, peut-être plus hédoniste qu’épicurienne, l’époque contemporaine impose le plaisir et son désir comme nouvelle norme. Dès lors, quel est notre rapport à la pulsion, au désir compulsif, au dépassement des limites imposées aux besoins et aux envies socialement acceptables ? Comment notre société régule le désir ? Comment la politique et les médias concourent-ils à le structurer, voire à le prescrire ? Quels mécanismes à l’œuvre dans l’addiction contredisent cette prescription, et surtout : s’agit-il véritablement d’une contradiction ? Notre culture de performance et satisfaction rapides peut effectivement expliquer certaines dépendances induites par leur objet ; néanmoins, la véritable addiction mentale se nourrit d’éléments plus profondément constitutifs de l’identité de l’homme moderne et contemporain : avant tout, la fragilité des acquis, la

Vaccination strategies for SIR vector-transmitted diseases.

Science.gov (United States)

Cruz-Pacheco, Gustavo; Esteva, Lourdes; Vargas, Cristobal

2014-08-01

Vector-borne diseases are one of the major public health problems in the world with the fastest spreading rate. Control measures have been focused on vector control, with poor results in most cases. Vaccines should help to reduce the diseases incidence, but vaccination strategies should also be defined. In this work, we propose a vector-transmitted SIR disease model with age-structured population subject to a vaccination program. We find an expression for the age-dependent basic reproductive number R(0), and we show that the disease-free equilibrium is locally stable for R(0) ≤ 1, and a unique endemic equilibrium exists for R(0) > 1. We apply the theoretical results to public data to evaluate vaccination strategies, immunization levels, and optimal age of vaccination for dengue disease.

Impulsive vaccination and dispersal on dynamics of an SIR epidemic model with restricting infected individuals boarding transports

Science.gov (United States)

Jiao, Jianjun; Cai, Shaohong; Li, Limei

2016-05-01

To understand the effect of impulsive vaccination and restricting infected individuals boarding transports on disease spread, we establish an SIR model with impulsive vaccination, impulsive dispersal and restricting infected individuals boarding transports. This SIR epidemic model for two regions, which are connected by transportation of non-infected individuals, portrays the evolvement of diseases. We prove that all solutions of the investigated system are uniformly ultimately bounded. We also prove that there exists globally asymptotically stable infection-free boundary periodic solution. The condition for permanence is discussed. It is concluded that the approach of impulsive vaccination and restricting infected individuals boarding transports provides reliable tactic basis for preventing disease spread.

Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination

Directory of Open Access Journals (Sweden)

Anqi Miao

2017-01-01

Full Text Available A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control.

Education and Utopia: Robert Owen and Charles Fourier

Science.gov (United States)

Leopold, David

2011-01-01

The aims of education, and the appropriate means of realising them, are a recurring preoccupation of utopian authors. The utopian socialists Robert Owen (1771-1858) and Charles Fourier (1772-1837) both place human nature at the core of their educational views, and both see education as central to their wider objective of social and political…

Unusually Gothic : Robert Sigl's Laurin (1987)

OpenAIRE

Stiglegger, Marcus

2010-01-01

Marcus Stiglegger revives a lost Gothic treasure in this brief discussion of Robert Sigl's Laurin—a rare case of German genre film-making and the heir to FW Murnau's legacy. Phantastic genre cinema is very rare in contemporary Germany—especially in the 1980s, the time when Italian horror reached another peak with Dario Argento's Opera (1985). The cliché of the German "easy comedy" ruled mainstream film production at the time, and so it appeared a kind of miracle when 27-year-old writer/direct...

Architecture of (impossibilities: Robert Smithson's expositive spaces

Directory of Open Access Journals (Sweden)

Bráulio Romeiro

2012-06-01

Full Text Available This work investigates the North American artist Robert Smithson’s considerations on traditional expositive spaces: the museum and art gallery, as well as unusual and unexplored spaces by art up to that time. Looking through his texts we notice some enhanced perspectives and reset others, increasing limitation set on White Cube’s abstract and neutral quality and the substantiation on ideologies behind of these spaces manifestation.

Identifying settlements on the SIR-B images of Rimbobujang and the surrounding areas, Sumatra, Indonesia

Directory of Open Access Journals (Sweden)

Sutanto .

2013-07-01

SIR-B image proves to be a reasonably good tool to identify rural settlement in an open area, especially for that with high density of houses. Its use to identify towns and cities is more recommended.

Robert Hooke, 1635-1703.

Science.gov (United States)

Rowbury, Robin

2012-01-01

Robert Hooke was a polymath whose expertise during the 17th century spanned many different scientific areas. As a schoolboy on the Isle of Wight he was obsessed with the possibility of human flight and later became equally absorbed in cosmology and planetary motion. His skills as an artist were put to good use both as an architect following the Great Fire of London and before that in Micrographia. Although that book is best known for demonstrating the power of Hooke's microscope, Micrographia describes distant planetary bodies, the wave theory of light, the organic origin of fossils, and various other philosophical and scientific interests of its author The following thumbnail sketches of Hooke reveal him to be a man of enormous energy and imagination whose ideas were often pirated or under-rated.

Stylistic Analysis of Robert Browning's Poem "Patriot into Traitor

Science.gov (United States)

Ahmed, Mumtaz; Irshad, Ayesha

2015-01-01

The stylistic analysis of Robert Browning's poem "Patriot into Traitor" is done by using graphological, phonological, morphological and lexico-syntactic patterns. This analysis is helpful in decoding the underlying meanings of the poem. It clearly brings to surface what the poet really wants to impart.

SIR-A views our environment An Experiment in the Batu Angkal Area, West Kalimantan, Indonesia

Directory of Open Access Journals (Sweden)

Sutanto .

2013-07-01

Factors affecting the ease of identification are. mainly tonal contrast, shape, size, surface roughness, direction in relation to the illumination, and dielectric constant. Due to the future availability of SIR-B image of Kalimantan, further study is recommended.

[Sir Francis Galton: the father of eugenics].

Science.gov (United States)

Aubert-Marson, Dominique

2009-01-01

Not only was Sir Francis Galton a famous geographer and statistician, he also invented "eugenics" in 1883. Eugenics, defined as the science of improving racial stock, was developed from a new heredity theory, conceived by Galton himself, and from the evolution theory of Charles Darwin, transposed to human society by Herbert Spencer. Galton's eugenics was a program to artificially produce a better human race through regulating marriage and thus procreation. Galton put particular emphasis on "positive eugenics", aimed at encouraging the physically and mentally superior members of the population to choose partners with similar traits. In 1904, he presented his ideas in front of a vast audience of physicians and scientists in London. His widely-publicized lecture served as the starting point for the development of eugenics groups in Europe and the United States during the first half of the 20th century.

Influence of heat conductivity on the performance of RTV SIR coatings with different fillers

Energy Technology Data Exchange (ETDEWEB)

Siderakis, K [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, GR-26110 Patras (Greece); Agoris, D [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, Greece, GR-26500, Rion, Greece (Greece); Gubanski, S [High Voltage Laboratory, Department of Electric Power Engineering, Chalmers University of Technology, S-41296, Gothenburg (Sweden)

2005-10-07

Room temperature vulcanized silicone rubber (RTV SIR) coatings are employed in order to improve the pollution performance of high voltage ceramic insulators by imparting surface hydrophobicity. In this paper, the performance of three RTV SIR coatings containing different fillers is investigated in a salt-fog test. Alumina trihydrate (ATH) and silica are the fillers included in the formulation, aiming to increase the material endurance to the energy supplied by the surface electrical activity during periods of hydrophobicity loss. The primary action of these fillers is to increase the material heat conductivity, i.e. the amount of energy conducted to the substrate. In addition, in the case of ATH relief is also achieved due to particle decomposition. The results indicate that for the compositions commercially available, where low amounts of fillers are used, and under the conditions of the test, ATH filled coatings performed better than the silica filled ones. This is attributed to ATH decomposition which further relieves the material structure and therefore decelerates material aging.

The auriferous placer at Mount Robert, Pietersburg Greenstone belt

International Nuclear Information System (INIS)

Saager, R.; Muff, R.

1986-01-01

The Mount Robert gold placer near Potgietersrus occurs in coarse, matrix-supported conglomerates of the Uitkyk Formation within the Pietersburg greenstone belt. Sedimentological and mineralogical investigations indicate that the conglomerates and the ore minerals were derived from a greenstone provenance, and that they were deposited in a braided river environment within a rapidly subsiding trough. Lack of sedimentological concentration of the heavy minerals is considered to be the main reason for the low and erratic gold grades encountered (usually below 1 g/t) and, thus, the failure of all past mining ventures. The mineralogical composition of the Mount Robert ore closely resembles that of the Witwatersrand deposits. However, uraninite is absent, probably as a result of its complete removal by weathering processes. Remaining small uranium concentrations can still be detected within the conglomerates where they occur associated with grains of carbonaceous matter, leucoxene aggregates, and secondary iron-hydroxides. U3O8 values found in the conglomerates are given

TBT recommends : Vera Bila. The No Smoking Orchestra. Robert Plant

Index Scriptorium Estoniae

2005-01-01

Mustlasansambli Kale ja Vera Bila kontserdist 8. apr Tallinnas. Bosnia filmirežissööri Emir Kusturica ja tema ansambli No Smoking Orchestra kontserdist 12. apr. Riias. Inglise rocklaulja Robert Planti kontserdist 10. apr. Vilniuses

Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging.

Science.gov (United States)

Orlandi, Ivan; Pellegrino Coppola, Damiano; Strippoli, Maurizio; Ronzulli, Rossella; Vai, Marina

2017-01-01

Nicotinamide (NAM), a form of vitamin B 3 , is a byproduct and noncompetitive inhibitor of the deacetylation reaction catalyzed by Sirtuins. These represent a family of evolutionarily conserved NAD + -dependent deacetylases that are well-known critical regulators of metabolism and aging and whose founding member is Sir2 of Saccharomyces cerevisiae. Here, we investigated the effects of NAM supplementation in the context of yeast chronological aging, the established model for studying aging of postmitotic quiescent mammalian cells. Our data show that NAM supplementation at the diauxic shift results in a phenocopy of chronologically aging sir2Δ cells. In fact, NAM-supplemented cells display the same chronological lifespan extension both in expired medium and extreme Calorie Restriction. Furthermore, NAM allows the cells to push their metabolism toward the same outcomes of sir2Δ cells by elevating the level of the acetylated Pck1. Both these cells have the same metabolic changes that concern not only anabolic pathways such as an increased gluconeogenesis but also respiratory activity in terms both of respiratory rate and state of respiration. In particular, they have a higher respiratory reserve capacity and a lower non-phosphorylating respiration that in concert with a low burden of superoxide anions can affect positively chronological aging. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Kventin Tarantino + Robert Rodriges = Grainhaus, ili Kinonostalgija po-amerikanski / Andrei Sozinov

Index Scriptorium Estoniae

Sozinov, Andrei

2007-01-01

Filmiprojekt "Grindhouse" koosneb Robert Rodrigueze retroõudukast "Grindhouse : Õuduste planeet" ("Planet Terror") ja Quentin Tarantino 70-ndatest inspireeritud õudusfilmist "Surmakindel" ("Death Proof") : Ameerika Ühendriigid 2007

Global analysis of multi-strains SIS, SIR and MSIR epidemic models

OpenAIRE

Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier

2014-01-01

International audience; We consider SIS, SIR and MSIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maxim...

Competitive exclusion principle for SIS and SIR models with n strains

OpenAIRE

Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier

2012-01-01

We consider SIS and SIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maximum of each individual basic re...

Montaigne, Sir Ralph Bankes and other English readers of the Essais.

OpenAIRE

O'Brien, John

2013-01-01

This article deals with a hitherto unknown and unpublished early modern English manuscript account of Montaigne's Essais by Sir Ralph Bankes (1631?–77) of Kingston Lacy in Dorset. Bankes's account covers a range of features in Montaigne's work: crucial elements of self-portraiture such as judgement, but also his attitude to women and doctors. These characteristics are analysed and compared first with Montaigne's own pronouncements about the aspects Bankes selects and secondly with two other s...

SIR (Safe Integral Reactor) - reducing size can reduce cost

International Nuclear Information System (INIS)

Hayns, M.R.

1991-01-01

Traditional engineering economics have favoured the advantages of larger size as a means of reducing specific capital costs and hence unit generating costs. For large and small plants utilising the same concept, e.g. a small four-loop PWR vs a large four-loop PWR with the same number of components, economies of scale are well established. If, however, a smaller plant is sized to take advantage of features which are only feasible at smaller outputs, is of simpler design, with the advantage taken of the simplified design to produce the most cost-effective layout, and incorporates fewer, more easily replaceable components with minimal assembly on site, it is possible to produce a plant which is competitive with larger plant of more traditional design. When 'system' effects, such as better matching of installed capacity to the growth in demand and the fact that a smaller total capacity will be needed to meet a given demand with a specified level of confidence, are taken into account, it can be shown that a utility's overall cash-flow position can be improved with lower associated absolute financial risks. The UK/US Safe Integral Reactor (SIR) is an integral pressurized water reactor in the 300-400 MW(e) range which utilises conventional water reactor technology in a way not feasible at the very large, sizes of recent years. The SIR concept is briefly explained and its technical and economic advantages in terms of simplicity, construction, maintenance, availability, decommissioning, safety and siting described. The results of system analyses which demonstrate the overall financial advantages to a utility are presented. (author)

Procalcitonin, C-reactive protein and serum lactate dehydrogenase in the diagnosis of bacterial sepsis, SIRS and systemic candidiasis.

Science.gov (United States)

Miglietta, Fabio; Faneschi, Maria Letizia; Lobreglio, Giambattista; Palumbo, Claudio; Rizzo, Adriana; Cucurachi, Marco; Portaccio, Gerolamo; Guerra, Francesco; Pizzolante, Maria

2015-09-01

The aim of this study was to evaluate procalcitonin (PCT), C-reactive protein (CRP), platelet count (PLT) and serum lactate dehydrogenase (LDH) as early markers for diagnosis of SIRS, bacterial sepsis and systemic candidiasis in intensive care unit (ICU) patients. Based on blood culture results, the patients were divided into a sepsis group (70 patients), a SIRS group (42 patients) and a systemic candidiasis group (33 patients). PCT, CRP, LDH and PLT levels were measured on day 0 and on day 2 from the sepsis symptom onset. PCT levels were higher in Gram negative sepsis than those in Gram positive sepsis, although the P value between the two subgroups is not significant (P=0.095). Bacterial sepsis group had higher PCT and CRP levels compared with the systemic candidiasis group, whereas PLT and LDH levels showed similar levels in these two subgroups. The AUC for PCT (AUC: 0.892, P candidiasis groups (P=0.093 N.S.). In conclusion, PCT can be used as a preliminary marker in the event of clinical suspicion of systemic candidiasis; however, low PCT levels (candidiasis and SIRS groups.

De 'wraak van de geografie' volgens Robert D. Kaplan

NARCIS (Netherlands)

Mamadouh, V.

2013-01-01

De Amerikaanse publicist Robert D. Kaplan heeft een nieuwe bestseller, De wraak van de geografie, waarin hij het belang van geografie voor de internationale politiek uit de doeken doet. Zijn roep om meer aandacht voor geografie is echter erg eenzijdig en een miskenning van alles waar ons vak voor

Sir Ronald A. Fisher and the International Biometric Society.

Science.gov (United States)

Billard, Lynne

2014-06-01

The year 2012 marks the 50th anniversary of the death of Sir Ronald A. Fisher, one of the two Fathers of Statistics and a Founder of the International Biometric Society (the "Society"). To celebrate the extraordinary genius of Fisher and the far-sighted vision of Fisher and Chester Bliss in organizing and promoting the formation of the Society, this article looks at the origins and growth of the Society, some of the key players and events, and especially the roles played by Fisher himself as the First President. A fresh look at Fisher, the man rather than the scientific genius is also presented. © 2014, The International Biometric Society.

Antes de los Estudios Culturales. Robert Warshow y la experiencia

Directory of Open Access Journals (Sweden)

Antonio Lastra

2008-01-01

Full Text Available Este artículo estudia la influencia del concepto de experiencia que desarrolla Robert Warshow. Warshow ha supuesto el contrapunto americano a las teorías desarrolladas por Walter Benjamien en Europa. Si bien ambos insistieron en la pobreza de la experiencia, como resultado de la tecnificación de la sociedad, Warshow supo introducir matizaciones que influyeron en todo el círculo de intelectuales concentrados en Nueva York durante la etapa de consolidación de los Estudios Culturales. This paper studies the influence of the experience concept by Robert Warshow. Warshow is the American counterpoint to theories developed by Walter Benjamin in Europe. Although both insisted in the poverty of experience, as a result of technique, Warshow knew how to introduce nuances that influenced intellectuals in New York as Cultural Studies emerged.

Investigating Environmentally Sustainable Transport Based on DALY weights and SIR Method

Directory of Open Access Journals (Sweden)

Hossein Nezamianpour Jahromi

2012-09-01

Full Text Available Accessibility is one of the main causes of well-being and growth in contemporary societies. Transportation is the backbone of accessibility systems that lead to the growth of economic and social networks and spatial dispersion of activities. Unfortunately, the adverse effects of transportation have a great impact on the natural and human environment. Since transportation is associated with fossil fuel combustion, it results in emissions of pollutants that cause damage to human health. To save the global eco-system, sustainable development has become an international priority. To deal with the sustainability of transportation systems is an important issue as testified by a growing number of initiatives framed to define and measure sustainability in transportation planning and infrastructure planning as well. The capability of environmental assessment as a sustainability instrument is well known. This study proposes a new approach to rank countries based on environmental sustainability development applying disability adjusted life year (DALY weights for transportation sector emissions. DALY weights consider actual impacts of pollutants on human health. By employing SIR method, a superiority and inferiority ranking method is presented for multiple criteria decision making, the sustainability ranking of a number of European countries is presented. Three various ranking methods extracted from SIR ranking method are discussed and the results and the correlation among them are demonstrated.

Improvement on The Ellis and Roberts Viability Model

Directory of Open Access Journals (Sweden)

Guoyan Zhou

2016-05-01

Full Text Available With data sets of germination percent and storage time of seed lot of wheat and sorghum stored at three different storage temperature(t, °C with three different water content (m, % of seeds, together with data set of buckwheat and lettuce reported in literatures, the possibility that seed survival curve were transformed into line by survival proportion and the relationship that logarithm of average viability period (logp50 and standard deviation of seed death distribution in time (δwith t, m and interaction between t and m were analysed. Result indicated that survival proportion transformed seed survival curve to line were much easier than the probability adopted by Ellis and Roberts, and the most important factor affecting logp50 and δ of seed lot was interaction between t and m. Thus, Ellis and Roberts viability model were suggested to be improved as Ki=Vi-p/10K-CWT (t×m to predict longevity of seed lot with initial germination percent unknown, a new model of Gi/G0=A-P/10K-CWT(t×m was constructed to predict longevity of seed lot with initial germination percent already known.

Percy Julian, Robert Robinson, and the Identity of Eserethole

Science.gov (United States)

Ault, Addison

2008-01-01

The Nova production "Percy Julian--Forgotten Genius" included the very public disagreement between Percy Julian, an unknown American chemist, and Robert Robinson, possibly the best known organic chemist of the day, as to the identity of "eserethole", the key intermediate for the synthesis of the alkaloid physostigmine. The Nova production,…

Dynamic Behavior for an SIRS Model with Nonlinear Incidence Rate and Treatment

Directory of Open Access Journals (Sweden)

Junhong Li

2013-01-01

Full Text Available This paper considers an SIRS model with nonlinear incidence rate and treatment. It is assumed that susceptible and infectious individuals have constant immigration rates. We investigate the existence of equilibrium and prove the global asymptotical stable results of the endemic equilibrium. We then obtained that the model undergoes a Hopf bifurcation and existences a limit cycle. Some numerical simulations are given to illustrate the analytical results.

John Bingham Roberts and the first American monograph on human brain surgery.

Science.gov (United States)

Stone, J L

2001-10-01

JOHN BINGHAM ROBERTS (1852-1924) of Philadelphia was an active general surgeon in the latter 19th and early 20th centuries. He made pioneering contributions to a number of areas of surgery. From 1880 until the end of his career, he was one of the few American surgeons to advocate an aggressive exploratory approach to cranial fractures in an effort to avoid consequences such as infection, delayed seizures, and insanity. In his 1885 article in the Transactions of the American Surgical Association titled "The Field and Limitation of the Operative Surgery of the Human Brain," he predicted that with antiseptic precautions and the growing knowledge of cerebral localization, operations on the brain would become commonplace. This work predated that of Horsley, Keen, and many others. Roberts had a continuing interest in head injuries, cranial fractures, and the development of trephines and burrs for reconstructive cranial work, but his active enthusiasm for brain surgery diminished in the 1890s. Nevertheless, Roberts was a very prolific teacher and leader in American surgery who is perhaps best remembered for his monographs and textbooks on general, orthopedic, plastic, and reconstructive surgery.

PRENATAL DIAGNOSIS OF ROBERT/SC SYNDROME IN A DIABETIC MOTHER WITH A HISTORY OF MEBENDAZOLE AND GLIBENCLAMIDE INTAKE

Directory of Open Access Journals (Sweden)

M. Pourissa

2003-07-01

Full Text Available The Robert/SC (pseudothalidomide syndrome is a rare autosomal recessive disorder, associated with phocomelia and craniofacial abnormalities. An anomalous fetus with lower limb phocomelia and micromelia, lumbar myeloschisis, upper limb and ribs defects and craniofacial abnormalities is reported whose diabetic mother took mebendazole and glibenclamide in early pregnancy. Ultrasonographic findings of syndromes with phocomelia are discussed as well as Robert/SC syndrome which is the most probable diagnosis. Robert/SC phocomelia syndrome is a rare autosomal recessive condition characterized by severe pre and postnatal growth deficiency, symmetric limb reductions of variable severity and craniofacial anomalies including hypertelorism, hypoplastic nasal alae, cleft lip and palate. About half of the reported cases presented chromosomal abnormalities. We think that findings in our case are consistent with Robert/SC syndrome with additional abnormalities.

78 FR 12357 - Brockway Mould, Inc., a Division of Ross International Ltd. Including Robert Lerch From BJR...

Science.gov (United States)

2013-02-22

... Division of Ross International Ltd. Including Robert Lerch From BJR Trucking, Brockport, PA; Amended..., applicable to workers and former workers of Brockway Mould, Inc., a division of Ross International Ltd... Brockway Mould, Inc., a division of Ross International Ltd., including Robert Lerch from BJR Trucking...

Being Prepared: The Application of Character Building and the Beginning of the Boy Scouts of America.

Science.gov (United States)

Phelps, Richard

The beginnings of the Boy Scouts are traced, with particular emphasis on ideological foundation, social reform objectives of the founders (Sir Robert Baden-Powell, Daniel Carter Beard, and Ernest Thompson) and its relationship to other reform movements of the Progressive Era. The philosophical base of scouting is characterized as: 1) a…

Robert Aymar seals the last interconnect in the LHC

CERN Multimedia

Maximilien Brice

2007-01-01

The LHC completes the circle. On 7 November, in a brief ceremony in the LHC tunnel, CERN Director General Robert Aymar (Photo 1) sealed the last interconnect between the main magnets of the Large Hadron Collider (LHC). Jean-Philippe Tock, leader of the Interconnections team, tightens the last bolt (Photos 4-8).

Lyapunov functions and global stability for SIR and SEIR models with age-dependent susceptibility

KAUST Repository

Korobeinikov, Andrei; Melnik, Andrey V.

2013-01-01

We consider global asymptotic properties for the SIR and SEIR age structured models for infectious diseases where the susceptibility depends on the age. Using the direct Lyapunov method with Volterra type Lyapunov functions, we establish conditions for the global stability of a unique endemic steady state and the infection-free steady state.

Determination of the Geographical Origin of All Commercial Hake Species by Stable Isotope Ratio (SIR) Analysis.

Science.gov (United States)

Carrera, Mónica; Gallardo, José M

2017-02-08

The determination of the geographical origin of food products is relevant to comply with the legal regulations of traceability, to avoid food fraud, and to guarantee food quality and safety to the consumers. For these reasons, stable isotope ratio (SIR) analysis using an isotope ratio mass spectrometry (IRMS) instrument is one of the most useful techniques for evaluating food traceability and authenticity. The present study was aimed to determine, for the first time, the geographical origin for all commercial fish species belonging to the Merlucciidae family using SIR analysis of carbon (δ 13 C) and nitrogen (δ 15 N). The specific results enabled their clear classification according to the FAO (Food and Agriculture Organization of the United Nations) fishing areas, latitude, and geographical origin in the following six different clusters: European, North African, South African, North American, South American, and Australian hake species.

Positron-emitting resin microspheres as surrogates of 90Y SIR-Spheres: a radiolabeling and stability study

International Nuclear Information System (INIS)

Avila-Rodriguez, Miguel A.; Selwyn, Reed G.; Hampel, Joseph A.; Thomadsen, Bruce R.; DeJesus, Onofre T.; Converse, Alexander K.; Nickles, Robert J.

2007-01-01

Commercially available resin microspheres and SIR-Spheres were labeled with metallic positron emitters and evaluated as positron emission tomography (PET) imaging surrogates of 90 Y SIR-Spheres. Radiolabeling was performed using a batch method, and in vitro stability over 24 h was evaluated in saline at physiological pH at 37 o C. The activity per microsphere distribution, as evaluated by autoradiography, showed the activity per microsphere to be proportional to the square radius of the spheres, suggesting surface binding. The in vivo stability of radiolabeling was evaluated in rats by micro-PET imaging after the intravenous injection of labeled microspheres. The different resin microspheres and radionuclides evaluated in this study all showed good radiolabeling efficiency and in vitro stability. However, only resins labeled with 86 Y and 89 Zr proved to have the in vivo stability required for clinical applications

Robert Nozick's entitlement theory of justice: a critique | Nnajiofor ...

African Journals Online (AJOL)

The burden of this paper is to critique Robert Nozick's entitlement theory of justice which was drafted as an argument against traditional distribution theories. Nozick's theory of justice claims that whether a distribution is just or not depend entirely on how it came about. By contrast, justice according to equality, need, desert or ...

The threshold of a stochastic delayed SIR epidemic model with temporary immunity

Science.gov (United States)

Liu, Qun; Chen, Qingmei; Jiang, Daqing

2016-05-01

This paper is concerned with the asymptotic properties of a stochastic delayed SIR epidemic model with temporary immunity. Sufficient conditions for extinction and persistence in the mean of the epidemic are established. The threshold between persistence in the mean and extinction of the epidemic is obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number R0 of the deterministic system.

Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively.

Directory of Open Access Journals (Sweden)

Inbal Nussbaum

Full Text Available Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood, although deteriorated stress response is one of the hallmarks of aging. The budding yeast Saccharomyces cerevisiae is a valuable model organism to study the genetics of aging, because yeast ages within days and are amenable to genetic manipulations. As a unicellular organism, yeast has evolved robust systems to respond to environmental challenges. This response is orchestrated largely by the conserved transcription factor Hsf1, which in S. cerevisiae regulates expression of multiple genes in response to diverse stresses. Here we demonstrate that Hsf1 response to heat shock and oxidative stress deteriorates during yeast transition from exponential growth to stationary-phase, whereas Hsf1 activation by glucose starvation is maintained. Overexpressing Hsf1 does not significantly improve heat shock response, indicating that Hsf1 dwindling is not the major cause for Hsf1 attenuated response in stationary-phase yeast. Rather, factors that participate in Hsf1 activation appear to be compromised. We uncover two factors, Yap1 and Sir2, which discretely function in Hsf1 activation by oxidative stress and heat shock. In Δyap1 mutant, Hsf1 does not respond to oxidative stress, while in Δsir2 mutant, Hsf1 does not respond to heat shock. Moreover, excess Sir2 mimics the heat shock response. This role of the NAD+-dependent Sir2 is supported by our finding that supplementing NAD+ precursors improves Hsf1 heat shock response in stationary-phase yeast, especially when combined with expression of excess Sir2. Finally, the combination of excess Hsf1, excess Sir2 and NAD+ precursors rejuvenates the heat shock response.

Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively.

Science.gov (United States)

Nussbaum, Inbal; Weindling, Esther; Jubran, Ritta; Cohen, Aviv; Bar-Nun, Shoshana

2014-01-01

Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood, although deteriorated stress response is one of the hallmarks of aging. The budding yeast Saccharomyces cerevisiae is a valuable model organism to study the genetics of aging, because yeast ages within days and are amenable to genetic manipulations. As a unicellular organism, yeast has evolved robust systems to respond to environmental challenges. This response is orchestrated largely by the conserved transcription factor Hsf1, which in S. cerevisiae regulates expression of multiple genes in response to diverse stresses. Here we demonstrate that Hsf1 response to heat shock and oxidative stress deteriorates during yeast transition from exponential growth to stationary-phase, whereas Hsf1 activation by glucose starvation is maintained. Overexpressing Hsf1 does not significantly improve heat shock response, indicating that Hsf1 dwindling is not the major cause for Hsf1 attenuated response in stationary-phase yeast. Rather, factors that participate in Hsf1 activation appear to be compromised. We uncover two factors, Yap1 and Sir2, which discretely function in Hsf1 activation by oxidative stress and heat shock. In Δyap1 mutant, Hsf1 does not respond to oxidative stress, while in Δsir2 mutant, Hsf1 does not respond to heat shock. Moreover, excess Sir2 mimics the heat shock response. This role of the NAD+-dependent Sir2 is supported by our finding that supplementing NAD+ precursors improves Hsf1 heat shock response in stationary-phase yeast, especially when combined with expression of excess Sir2. Finally, the combination of excess Hsf1, excess Sir2 and NAD+ precursors rejuvenates the heat shock response.

The influence of percutaneous nephrolithotomy on human systemic stress response, SIRS and renal function.

Science.gov (United States)

Shen, Pengfei; Wei, Wuran; Yang, Xiaochun; Zeng, Hao; Li, Xiong; Yang, Jie; Wang, Jia; Huang, Jiaoti

2010-10-01

The objective of this study is to investigate the influences of percutaneous nephrolithotomy (PNL) and open surgery nephrolithotomy on the systemic stress response, SIRS and renal function. Forty patients with kidney calculi were enrolled in the study. Twenty cases were randomized to the PNL group and the other twenty cases to the open surgery group. Levels of C-reactive protein (CRP), interleukin-6(IL-6), β(2)-microglobulin (β(2)-MG), respiration rate, heart rate, body temperature and white blood cell counts were examined. CRP and IL-6 were measured in all patients pre-operatively and on post-operative days 1, 3 and 6, respectively. There was significant difference in their pre- and post-operation levels (P PNL group and 12 cases in open surgery group; there was significant difference between the two groups (P 0.05). Urine β(2)-MG levels were also measured. There was significant difference between pre- and the first day post-PNL (P PNL (P > 0.05). There was significant difference between pre- and first and third day post-open surgery (P 0.05). There was significant difference between two groups at the first, third and sixth days (P PNL group and open surgery group to some extent. The degree of stress response of PNL is lower than that of open surgery, proving the advantages of PNL with reference to serum immunology. There were cases in both the groups with SIRS, but the degree of SIRS in PNL group was lesser than the other group. Both the groups have no obvious effect on glomerular filtration function after operation and have effect on renal tubular reabsorption in the early stage after operation; but the recovery of the PNL group is faster than the open surgery group. It is thus shown that PNL is much safer and more feasible and has lesser effect on renal function.

The strange trial of Robert Oppenheimer; L'etrange proces de Robert Oppenheimer

Energy Technology Data Exchange (ETDEWEB)

Kevles, D.J. [Yale Univ., New Haven, CT (United States); Institut de Technologie de Californie (United States)

2004-04-01

Robert Oppenheimer has become the symbol of the scientist tormented and anguished by the consequences of his discoveries. R.Oppenheimer took a major part in the Manhattan project for the designing of the first atomic bomb. During this period he considered the thermonuclear bomb as the next step to reach but after Japan's surrender he reconsidered his position and favoured a more moderate atomic policy. R.Oppenheimer began to militate in favour of an international control of nuclear energy and wanted that Usa relinquish to design the hydrogen bomb. In 1953 in full Mac-Carthysm era, he was accused of being a communist and of spying for Ussr and as a consequence he was deprived of his office in AEC (atomic energy committee) but in 1963 president Lyndon Johnson rehabilitated him and R.Oppenheimer was awarded the highest reward of AEC: the Enrico Fermi prize. (A.C.)

Medicinal use of earths and minerals from Hippocrates to Sir Hans Sloane and beyond.

Science.gov (United States)

Retsas, Spyros

2012-12-01

In 1931 two pharmaceutical drawers containing mineral specimens, belonging to Sir Hans Sloane, the 18th century collector, Royal Physician, President of the Royal Society and of the Royal College of Physicians of London, were found in the Department of Botany of the Natural History Museum (NHM) of London. The drawers, each divided into 49 compartments, contained a total of 107 mineral pharmaceutical specimens, some labelled as mercury or white arsenic. Their registration, identification with the Sloane Manuscript Catalogues and subsequent transfer to the Mineralogy department of the NHM where one of these drawers is now on public display, had been documented by 1935. In antiquity therapeutic empiricism attributed medicinal properties to animal products, plants and minerals, including the soil of specific geographic locations. This communication traces the medicinal use of certain earths and minerals, listed in Sir Hans Sloane's manuscript catalogues, to classical antiquity with a reference to Arsenic compounds, which in our time are finding application in the treatment of acute promyelocytic leukaemia and to Terra Lemnia, a celebrated antidote of repute spanning twenty centuries, also included in the Sloane collections.

Robert Spitzer and psychiatric classification: technical challenges and ethical dilemmas.

Science.gov (United States)

Jacob, K S

2016-01-01

Dr Robert Leopold Spitzer (May 22, 1932-December 25, 2015), the architect of modern psychiatric diagnostic criteria and classification, died recently at the age of 83 in Seattle. Under his leadership, the American Psychiatric Association's (APA) Diagnostic and Statistical Manuals (DSM) became the international standard.

The Threshold of a Stochastic SIRS Model with Vertical Transmission and Saturated Incidence

Directory of Open Access Journals (Sweden)

Chunjuan Zhu

2017-01-01

Full Text Available The threshold of a stochastic SIRS model with vertical transmission and saturated incidence is investigated. If the noise is small, it is shown that the threshold of the stochastic system determines the extinction and persistence of the epidemic. In addition, we find that if the noise is large, the epidemic still prevails. Finally, numerical simulations are given to illustrate the results.

Traveling waves in a delayed SIR model with nonlocal dispersal and nonlinear incidence

Science.gov (United States)

Zhang, Shou-Peng; Yang, Yun-Rui; Zhou, Yong-Hui

2018-01-01

This paper is concerned with traveling waves of a delayed SIR model with nonlocal dispersal and a general nonlinear incidence. The existence and nonexistence of traveling waves of the system are established respectively by Schauder's fixed point theorem and two-sided Laplace transform. It is also shown that the spread speed c is influenced by the dispersal rate of the infected individuals and the delay τ.

Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90α in Severe Sepsis and SIRS

Directory of Open Access Journals (Sweden)

K. Vardas

2014-01-01

Full Text Available Objective. To evaluate the early heat shock protein (HSP and hormonal stress response of intensive care unit (ICU patients with severe sepsis/septic shock (SS or systemic inflammatory response syndrome (SIRS compared to healthy subjects (H. Methods. Patients with early (first 48 hrs SS (n=29 or SIRS (n=29 admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72 and interleukins. Mean fluorescence intensity (MFI values for intracellular HSPs (iHSP72, iHSP90α were measured using 4-colour flow-cytometry. Results. Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H (P<0.003. ACTH and eHSP72 were significantly higher in SS and SIRS compared to H (P<0.005. SS monocytes expressed lower iHSP72 MFI levels compared to H (P=0.03. Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate (P<0.05. In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10. Conclusion. Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.

Conceptualising Childhood: Robert Louis Stevenson's "A Child's Garden of Verses."

Science.gov (United States)

Webb, Jean

2002-01-01

Discusses the construct of childhood in Robert Louis Stevenson's collection of poems, "A Child's Garden of Verses," by employing notions of child development drawn from Jean Piaget and Lev Vygotsky. Finds, from a literary perspective, Stevenson's collection located on the boundaries of romanticism and modernism. (BT)

The threshold of a stochastic delayed SIR epidemic model with vaccination

Science.gov (United States)

Liu, Qun; Jiang, Daqing

2016-11-01

In this paper, we study the threshold dynamics of a stochastic delayed SIR epidemic model with vaccination. We obtain sufficient conditions for extinction and persistence in the mean of the epidemic. The threshold between persistence in the mean and extinction of the stochastic system is also obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number Rbar0 of the deterministic system. Results show that time delay has important effects on the persistence and extinction of the epidemic.

75 FR 53861 - Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk...

Science.gov (United States)

2010-09-02

... Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk 22, and DH.C1...). ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for all Robert E. Rust... CFR part 39) to include an AD that would apply to all Robert E. Rust, Jr. Models DeHavilland DH.C1...

Robert Lacoste's the darker side practical applications for electronic design concepts from circuit cellar

CERN Document Server

Lacoste, Robert

2009-01-01

Robert Lacoste's The Darker Side column has quickly become a must read among Circuit Cellar devotees. His column provides readers with succinct theoretical concepts and practical applications on topics as far reaching as digital modulation to antenna basics. Difficult concepts are demystified as Robert shines a light on complex topics within electronic design.This book collects sixteen Darker Side articles that have been enriched with new, exclusive content from the author. An intro into The Darker Side will give examples of material that can enhance and optimize the way you design. A

Sprawl: A Compact History (Author: Robert Bruegmann)

OpenAIRE

Hayter, Jason Alexander

2006-01-01

Search a well-stocked library or bookstore for works on urban form and you might reach the same conclusion drawn by Robert Bruegmann: "Most of what has been written about sprawl to date has been written about com­ plaints" (p. 3). But what separates Bruegmann, a professor of art history, architecture, and urban planning at the University of Illinois at Chicago, from most people is what he does next. "[S]o many 'right-minded' people were so vociferous on the subject that I began to suspect tha...

An individual-based approach to SIR epidemics in contact networks.

Science.gov (United States)

Youssef, Mina; Scoglio, Caterina

2011-08-21

Many approaches have recently been proposed to model the spread of epidemics on networks. For instance, the Susceptible/Infected/Recovered (SIR) compartmental model has successfully been applied to different types of diseases that spread out among humans and animals. When this model is applied on a contact network, the centrality characteristics of the network plays an important role in the spreading process. However, current approaches only consider an aggregate representation of the network structure, which can result in inaccurate analysis. In this paper, we propose a new individual-based SIR approach, which considers the whole description of the network structure. The individual-based approach is built on a continuous time Markov chain, and it is capable of evaluating the state probability for every individual in the network. Through mathematical analysis, we rigorously confirm the existence of an epidemic threshold below which an epidemic does not propagate in the network. We also show that the epidemic threshold is inversely proportional to the maximum eigenvalue of the network. Additionally, we study the role of the whole spectrum of the network, and determine the relationship between the maximum number of infected individuals and the set of eigenvalues and eigenvectors. To validate our approach, we analytically study the deviation with respect to the continuous time Markov chain model, and we show that the new approach is accurate for a large range of infection strength. Furthermore, we compare the new approach with the well-known heterogeneous mean field approach in the literature. Ultimately, we support our theoretical results through extensive numerical evaluations and Monte Carlo simulations. Published by Elsevier Ltd.

Isonicotinamide Enhances Sir2 Protein-mediated Silencing and Longevity in Yeast by Raising Intracellular NAD+ Concentration*

Science.gov (United States)

McClure, Julie M.; Wierman, Margaret B.; Maqani, Nazif; Smith, Jeffrey S.

2012-01-01

Sirtuins are an evolutionarily conserved family of NAD+-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD+ concentration through the combined action of NAD+ biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD+ precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the nicotinamidase Pnc1 converts NAM to nicotinic acid (NA), which is then used as a substrate by the NAD+ salvage pathway enzyme NA phosphoribosyltransferase (Npt1). Isonicotinamide (INAM) is an isostere of NAM that stimulates yeast Sir2 deacetylase activity in vitro by alleviating the NAM inhibition. In this study, we determined that INAM stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD+ concentration. INAM enhanced normal silencing at the rDNA locus but only partially suppressed the silencing defects of an npt1Δ mutant. Yeast cells grown in media lacking NA had a short replicative life span, which was extended by INAM in a SIR2-dependent manner and correlated with increased NAD+. The INAM-induced increase in NAD+ was strongly dependent on Pnc1 and Npt1, suggesting that INAM increases flux through the NAD+ salvage pathway. Part of this effect was mediated by the NR salvage pathways, which generate NAM as a product and require Pnc1 to produce NAD+. We also provide evidence suggesting that INAM influences the expression of multiple NAD+ biosynthesis and salvage pathways to promote homeostasis during stationary phase. PMID:22539348

Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.

Science.gov (United States)

McClure, Julie M; Wierman, Margaret B; Maqani, Nazif; Smith, Jeffrey S

2012-06-15

Sirtuins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD(+) concentration through the combined action of NAD(+) biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD(+) precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the nicotinamidase Pnc1 converts NAM to nicotinic acid (NA), which is then used as a substrate by the NAD(+) salvage pathway enzyme NA phosphoribosyltransferase (Npt1). Isonicotinamide (INAM) is an isostere of NAM that stimulates yeast Sir2 deacetylase activity in vitro by alleviating the NAM inhibition. In this study, we determined that INAM stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD(+) concentration. INAM enhanced normal silencing at the rDNA locus but only partially suppressed the silencing defects of an npt1Δ mutant. Yeast cells grown in media lacking NA had a short replicative life span, which was extended by INAM in a SIR2-dependent manner and correlated with increased NAD(+). The INAM-induced increase in NAD(+) was strongly dependent on Pnc1 and Npt1, suggesting that INAM increases flux through the NAD(+) salvage pathway. Part of this effect was mediated by the NR salvage pathways, which generate NAM as a product and require Pnc1 to produce NAD(+). We also provide evidence suggesting that INAM influences the expression of multiple NAD(+) biosynthesis and salvage pathways to promote homeostasis during stationary phase.

Invited commentary on 'Robert G Edwards and the Roman Catholic Church'.

Science.gov (United States)

Head, Ivan Francis

2011-06-01

In this issue of Reproductive BioMedicine Online, Benagiano, Carrara and Filippi have produced a clearly written and comprehensive account of why the Roman Catholic Church has not welcomed the award of the 2010 Nobel Prize in Physiology and Medicine to Dr Robert G Edwards for the development of human IVF. I commend the article for its clarity and lucidity but attempt to point out some areas where disagreement even with its nuanced opposition to IVF may be legitimate. I try to make some simple comments that explain why this is so and I suggest some areas to which contemporary theology and philosophy can commit itself. But it is good to see even a nuanced response to the work of Robert G Edwards rather than a blanket condemnation. Copyright © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Microstrip Cross-coupled Interdigital SIR Based Bandpass Filter

Directory of Open Access Journals (Sweden)

R. K. Maharjan

2012-09-01

Full Text Available A simple and compact 4.9 GHz bandpass filter for C-band applications is proposed. This paper presents a novel microstrip cross-coupled interdigital half-wavelength stepped impedance resonator (SIR based bandpass filter (BPF.The designed structure is similar to that of a combination of two parallel interdigital capacitors. The scattering parameters of the structure are measured using vector network analyzer (VNA. The self generated capacitive and inductive reactances within the interdigital resonators exhibited in a resonance frequency of 4.9 GHz. The resonant frequency and bandwidth of the capacitive cross-coupled resonator is directly optimized from the physical arrangement of the resonators. The measured insertion loss (S21 and return loss (S11 were 0.3 dB and 28 dB, respectively, at resonance frequency which were almost close to the simulation results.

Introduction : L'étendue des travaux de Robert Buijtenhuis

NARCIS (Netherlands)

Binsbergen, van W.M.J.; Konings, P.J.J.; Binsbergen, van W.M.J.; Hesseling, G.S.C.M.

2000-01-01

Cet ouvrage présente onze contributions rédigées par des africanistes qui ont collaboré étroitement avec l'anthropologue politique néerlandais Robert Buijtenhuijs et ont été influencés par ses travaux et sa personnalité. Le livre est un hommage à un auteur qui a été productif dans beaucoup de

Robert J. Aumann - matemaatikust Nobeli preemia laureaat / Peeter Puusemp

Index Scriptorium Estoniae

Puusemp, Peeter, 1947-

2006-01-01

2005. a. Nobeli preemia majanduse alal silmapaistva panuse eest mänguteooria ülesannete lahendamisse saanud Robert J. Aumannist ja D. Saari loetelu matemaatikutest - Nobeli preemia laureaatidest: John Nash'ist, Herbert Hauptman'ist, John Pople'ist, Bertrand Arthur William Russell'ist, Kenneth Joseph Arrow'ist, Gerard Debreu'ist, Leonid Vitaljevitš Kantorovitš'ist, Reinhard Selten'ist, Jan Tinbergen'ist

Kablilt Casablancasse : Eesti suurim seikleja John Robert Ignace Lepp 100 / Vello Salo

Index Scriptorium Estoniae

Salo, Vello, 1925-

2009-01-01

Eesti päritolu seikleja John Robert Lepp, Prantsusmaal tuntud kui katoliku kiriku preester Ignace Lepp, avaldas prantsuse ja saksa keeles hulgaliselt raamatuid psühholoogia, filosoofia ja religiooni valdkonnast

Sir Charles Alfred Ballance (1856-1936) and the introduction of facial nerve crossover anastomosis in 1895

NARCIS (Netherlands)

Van de Graaf, Robert C.; Ijpma, Frank F. A.; Nicolai, Jean-Philippe A.

Sir Charles Ballance (1856-1936) was the first surgeon in history to perform a facial nerve crossover anastomosis in 1895. Although, recently, several papers on the history of facial nerve surgery have been published, little is known about this historically important operation, the theoretical

The β-1,3-glucanosyltransferase Gas1 regulates Sir2-mediated rDNA stability in Saccharomyces cerevisiae.

Science.gov (United States)

Ha, Cheol Woong; Kim, Kwantae; Chang, Yeon Ji; Kim, Bongkeun; Huh, Won-Ki

2014-07-01

In Saccharomyces cerevisiae, the stability of highly repetitive rDNA array is maintained through transcriptional silencing. Recently, a β-1,3-glucanosyltransferase Gas1 has been shown to play a significant role in the regulation of transcriptional silencing in S. cerevisiae. Here, we show that the gas1Δ mutation increases rDNA silencing in a Sir2-dependent manner. Remarkably, the gas1Δ mutation induces nuclear localization of Msn2/4 and stimulates the expression of PNC1, a gene encoding a nicotinamidase that functions as a Sir2 activator. The lack of enzymatic activity of Gas1 or treatment with a cell wall-damaging agent, Congo red, exhibits effects similar to those of the gas1Δ mutation. Furthermore, the loss of Gas1 or Congo red treatment lowers the cAMP-dependent protein kinase (PKA) activity in a cell wall integrity MAP kinase Slt2-dependent manner. Collectively, our results suggest that the dysfunction of Gas1 plays a positive role in the maintenance of rDNA integrity by decreasing PKA activity and inducing the accumulation of Msn2/4 in the nucleus. It seems that nuclear-localized Msn2/4 stimulate the expression of Pnc1, thereby enhancing the association of Sir2 with rDNA and promoting rDNA stability. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Underwater EVA training in the WETF with astronaut Robert L. Stewart

Science.gov (United States)

1983-01-01

Underwater extravehicular activity (EVA) training in the weightless environment training facility (WETF) with astronaut Robert L. Stewart. Stewart is simulating a planned EVA using the mobile foot restraint device and a one-G version of the Canadian-built remote manipulator system.

A Pedagogy of Sight: Microscopic Vision in Robert Hooke's "Micrographia"

Science.gov (United States)

Jack, Jordynn

2009-01-01

Robert Hooke's "Micrographia" (1665) holds an important place in the history of scientific visual rhetoric. Hooke's accomplishment lies not only in a stunning array of engravings, but also in a "pedagogy of sight"--a rhetorical framework that instructs readers how to view images in accordance with an ideological or epistemic program. Hooke not…

76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

Science.gov (United States)

2011-11-17

... agencies to perform meaningless tasks. See Layfe Robert Anthony, M.D., 67 FR 35582 (DEA 2002); Michael G.... Kirk v. Mullen, 749 F.2d 297 (6th Cir. 1984); Puerto Rico Aqueduct and Sewer Auth. v. EPA, 35 F.3d 600...

New approaches to improve a WCDMA SIR estimator by employing different post-processing stages

Directory of Open Access Journals (Sweden)

Amnart Chaichoet

2008-09-01

Full Text Available For effective control of transmission power in WCDMA mobile systems, a good estimate of signal-to-interference ratio (SIR is needed. Conventionally, an adaptive SIR estimator employs a moving average (MA filter (Yoon et al., 2002 to encounter fading channel distortion. However, the resulting estimate seems to have high estimation error due to fluctuation in the channel variation. In this paper, an additional post-processing stage is proposed to improve the estimation accuracy by reducing the variation of the estimate. Four variations of post-processing stages, namely 1 a moving average (MA postfilter,2 an exponential moving average (EMA post-filter, 3 an IIR post-filter and 4 least-mean-squared (LMS adaptive post-filter, are proposed and their optimal performance in terms of root-mean-square error (RMSE are then compared by simulation. The results show the best comparable performance when the MA and LMS post-filter are used. However, the MA post-filter requires a lookup table of filter order for optimal performance at different channel conditions, while the LMS post-filter can be used conveniently without a lookup table.

Design of power controller in CDMA system with power and SIR error minimization

Institute of Scientific and Technical Information of China (English)

Shulan KONG; Huanshui ZHANG; Zhaosheng ZHANG; Hongxia WANG

2007-01-01

In this paper, an uplink power control problem is considered for code division multiple access (CDMA) systems. A distributed algorithm is proposed based on linear quadratic optimal control theory. The proposed scheme minimizes the sum of the power and the error of signal-to-interference ratio (SIR). A power controller is designed by constructing an optimization problem of a stochastic linear quadratic type in Krein space and solving a Kalman filter problem.

[Robert Koch was right. Towards a new interpretation of tuberculin therapy].

Science.gov (United States)

Cardona, Pere J

2006-01-01

At the centenary of Robert Koch's Nobel Prize award, tuberculosis treatment with tuberculin, which was announced in Berlin in 1890, is still considered a failure. Nevertheless, there is now sufficient information supporting the idea that tuberculin therapy was widely used until the second half of the twentieth century; thus, the impact of this treatment should be studied and related to the decrease in tuberculosis-related mortality recorded in that period. Moreover, tuberculin therapy has inspired at least two new immunotherapies; these, however, were directed toward precisely the opposite effect: suppression of the Koch phenomenon. Thus, inoculation of Mycobacterium vaccae polarizes the immune response towards the Th1 type; and inoculation of RUTI avoids local immunodepression after short-term chemotherapy without inducing toxicity. For this reason, Robert Koch's work on antituberculosis therapy should be reread and proper recognition given to his contribution in this field.

A 2004 unanswered letter to the Economist magazine requesting a retraction (and apology).

Science.gov (United States)

Ling, Gilbert N

2012-01-01

This is a copy of (the bulk of) a letter I mailed on May 13, 2004 to Sir Robert P. Wilson, President, and three editors of the magazine, the Economist. With the letter, I also sent each recipient a copy of my latest book, "Life at the Cell and Below-Cell Level" as a gesture of good will.

Doctor Julius Robert Mayer and Energy Processes in Living Systems

Science.gov (United States)

Erlichson, Herman

2007-01-01

The overwhelming majority of important papers in physics are written by physicists. But the physician Julius Robert Mayer (1814-1878, see photo) did a valid theoretical calculation of the mechanical equivalent of heat just before Joule reported on his results from his well-known paddle-wheel experiments. Joule is well-known to physics people and…

ROBERT autonomous navigation robot with artificial vision

International Nuclear Information System (INIS)

Cipollini, A.; Meo, G.B.; Nanni, V.; Rossi, L.; Taraglio, S.; Ferjancic, C.

1993-01-01

This work, a joint research between ENEA (the Italian National Agency for Energy, New Technologies and the Environment) and DIGlTAL, presents the layout of the ROBERT project, ROBot with Environmental Recognizing Tools, under development in ENEA laboratories. This project aims at the development of an autonomous mobile vehicle able to navigate in a known indoor environment through the use of artificial vision. The general architecture of the robot is shown together with the data and control flow among the various subsystems. Also the inner structure of the latter complete with the functionalities are given in detail

Remediating Language Deficient/Dyslexic College Students: An Interview with Robert Nash.

Science.gov (United States)

Lundquist, Arlene J.; Nash, Robert

1988-01-01

Robert Nash responds to questions concerning his personal and professional background, the Simultaneous Multisensory Instructional Procedure for Teaching the Complete Sound Structure of the Language, problems associated with dyslexia, the social/emotional impact of learning disabilities, and the University of Wisconsin's Project Success for…

Kollaaž ja kontekst. Robert Rumase liiklusmärgid Tallinnas / Hanno Soans

Index Scriptorium Estoniae

Soans, Hanno, 1974-

2004-01-01

Sekkuv kunst. Poola kunstniku Robert Rumase (1966) rahvusvahelisest kunstiprojektist "Linnamanöövrid", Kai Kaljo videost "One way to see America", Krzysztof Wodicko "Kodutute projektsioonist" ja New York City Unioni väljaku ümberkorraldamisest

Must, valge + hall : Sam Wagstaffi ja Robert Mapplethorpe'i portree / Madis Palm

Index Scriptorium Estoniae

Palm, Madis

2008-01-01

Dokumentaalfilm "Black, White & Gray: Sam Wagstaff and Robert Mapplethorpe" : autor ja režissöör James Crump : Ameerika Ühendriigid 2007. Filmi näidati filminädala "Art in America" raames Tallinnas

Crystallization and preliminary X-ray diffraction studies of the putative haloalkane dehalogenase DppA from Plesiocystis pacifica SIR-I

International Nuclear Information System (INIS)

Bogdanović, Xenia; Hesseler, Martin; Palm, Gottfried J.; Bornscheuer, Uwe T.; Hinrichs, Winfried

2010-01-01

The crystallization and preliminary X-ray diffraction studies of DppA from P. pacifica SIR-I are reported. DppA from Plesiocystis pacifica SIR-I is a putative haloalkane dehalogenase (EC 3.8.1.5) and probably catalyzes the conversion of halogenated alkanes to the corresponding alcohols. The enzyme was expressed in Escherichia coli BL21 and purified to homogeneity by ammonium sulfate precipitation and reversed-phase and ion-exchange chromatography. The DppA protein was crystallized by the vapour-diffusion method and protein crystals suitable for data collection were obtained in the orthorhombic space group P2 1 2 1 2. The DppA crystal diffracted X-rays to 1.9 Å resolution using an in-house X-ray generator

One day, Sir, you may tax it

CERN Multimedia

2011-01-01

“One day, Sir, you may tax it”… Those are the words I used to get the audience's attention during my talk at the World Economic Forum’s annual meeting in Davos, where I was invited to speak about the science agenda in 2011. For those of you who don’t know the quote, it was Michael Faraday’s response to William Gladstone when asked to comment on the utility of his blue-sky research into the newfangled phenomenon of electricity.   So what does a 19th century English scientist have to do with the science agenda today? A great deal, I would contend. Faraday was doing basic science, but he had the foresight to realise that through applied research his findings could one day be developed into something taxable – as it turned out, electric light. Faraday had a sense of the potential of his blue-sky research, but he also appreciated that basic science alone is not enough. This was my key message in Davos. Governments often speak of ...

Drawings of fossils by Robert Hooke and Richard Waller

Science.gov (United States)

Kusukawa, Sachiko

2013-01-01

The drawings of fossils by Robert Hooke and Richard Waller that were the basis of the engravings in Hooke's Posthumous works (1705) are published here for the first time. The drawings show that both Hooke and Waller were proficient draftsmen with a keen eye for the details of petrified objects. These drawings provided Hooke with a polemic edge in making the case for the organic origins of ‘figured stones’.

Lydia J. Roberts's Nutrition Research and the Rhetoric of "Democratic" Science

Science.gov (United States)

Jack, Jordynn

2009-01-01

This article examines nutritionist Lydia J. Roberts's use of the "democratic approach" as a rhetorical strategy both to build solidarity among scientists and to enact participatory research in a rural Puerto Rican community. This example suggests that participatory scientific methodologies are not necessarily democratic but may function…

Gay theatre, AIDS, and taboo: reconsidering Robert Chesley.

Science.gov (United States)

Gavrila, Rebecca

2013-01-01

Theatre was among the first popular culture forms to address HIV/AIDS and did so memorably in such works as The Normal Heart, As Is, Love! Valor! Compassion!, and March of the Falsettos. As a response to criticisms of stage dramas focusing on HIV/AIDS in the main as undifferentiated and melodramatic, the author suggests critical consideration of two works by playwright Robert Chesley. In her analysis of Night Sweats and Jerker, the author argues Chesley offers an alternative perspective that is both liberatory and sex-positive.

Robert Hooke (1635-1703), in his own words.

Science.gov (United States)

Breathnach, C S

2003-11-01

The diaries and other writings of Robert Hooke (1635-1703), as well as those of his contemporaries, are drawn upon to sketch his social and scientific life. An account is presented of his involvement with the Royal Society from its earliest days, and of his relations with notable scientists. In exploring the similarity between combustion and respiration, he established that air is composed of different gases, and that it is not motion of the lungs but a supply of fresh air that is necessary for life.

Thermal vacuum test of space equipment: tests of SIR-2 instrument Chandrayaan-1 mission

Science.gov (United States)

Sitek, P.

2008-11-01

We describe the reasons of proceeding Thermal-Vacuum tests for space electronic. We will answer on following questions: why teams are doing TV tests, what kind of phases should be simulated, which situations are the most critical during TV tests, what kind of results should be expected, which errors can be detect. As an example, will be shown TV-test of SIR-2 instrument for Chandrayaan-1 moon mission.

Rejsen og blikket. Italiensk litteratur 1980-1998 (ISBN 87-7445-819-1)

DEFF Research Database (Denmark)

Petersen, Lene Waage; Grundtvig, Birgitte

De nye fortællere, Postmodernisme, Genrer, Kvindelige forf., Rejsen som tema, Synlighedens poetik, Forf.port.(Morante, P. Levi, Sciascia, Calvino, Celati, Magris / LWP) (Benni, Tondelli, m.fl. / BG)...

The importance of chromosome studies in Roberts syndrome/SC phocomelia and other cohesinopathies.

Science.gov (United States)

Gerkes, Erica H; van der Kevie-Kersemaekers, Anne-Marie F; Yakin, Mariam; Smeets, Dominique F C M; van Ravenswaaij-Arts, Conny M A

2010-01-01

Roberts syndrome/SC phocomelia is a rare, autosomal recessive syndrome characterised by pre- and postnatal growth retardation, microcephaly, craniofacial anomalies, mental retardation, and tetraphocomelia in varying degrees of severity. The clinical diagnosis can be challenging in phenotypically mild cases. In the extremely mild case presented here, specific mitotic abnormalities were detected and proved to be very helpful, since Roberts syndrome/SC phocomelia could be diagnosed after finding premature centromere separation and somatic aneuploidy at routine karyotyping. We discuss these and other mitotic cytogenetic abnormalities that can be of significant diagnostic importance, but which will be missed if only array studies are performed. We also discuss the difference between premature centromere separation and premature (sister) chromatid separation. Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.

[Robert Schweitzer. Finnland, das Zarenreich und die Deutschen] / Karsten Bgüggemann

Index Scriptorium Estoniae

Brüggemann, Karsten, 1965-

2011-01-01

Arvustus: Robert Schweitzer. Finnland, das Zarenreich und die Deutschen : gesammelte Studien zum europäischen Nordosten. Festgabe zum 60. Geburtstag des Verfassers. Hrsg. von Uta-Maria Liertz. (Veröffentlichungen der Aue-Stiftung. Bd. 20) Verlag Schmidt-Römhild

A biography of Robert de Kersauson, French volunteer with the ...

African Journals Online (AJOL)

One of the most colourful foreign volunteers in the Boer army in 1900-1902 was Robert de Kersauson de Pennendreff; young, handsome, gallant and devoted to the Boer cause until the bitter end of the war. His love for South Africa brought him after an absence of almost 40 years back to this country to find a quiet place to ...

Marian Roberts, Developing the Craft of Mediation: Reflections on Theory and Practice

Directory of Open Access Journals (Sweden)

Ghislaine M. Lanteigne

2008-10-01

Full Text Available In Developing the Craft of Mediation, Marian Roberts proposes that mediation is akin to a craft with its focus on learning from experience and from others working in the field to develop and master knowledge and skills.

Tüli Robert Smithsoni "Spiraalse muuli" taastamise ümber / Rael Artel

Index Scriptorium Estoniae

Artel, Rael, 1980-

2004-01-01

Ameerika maakunstniku Robert Smithsoni (1938-1973) töö "Spiral Jetty" / "Spiraalne muul", mis on ligi 30 aastat seisnud nähtamatult Utah' osariigis Suure Soolajärve põhjas, on praegu kogu ulatuses näha. Teose omanik Dia kunstikeskus on dilemma ees, kas muul restaureerida või mitte

Sawtooth events and O+ in the plasma sheet and boundary layer: CME- and SIR-driven events

Science.gov (United States)

Lund, E. J.; Nowrouzi, N.; Kistler, L. M.; Cai, X.; Liao, J.

2017-12-01

The role of ionospheric ions in sawtooth events is an open question. Simulations[1,2,3] suggest that O+ from the ionosphere produces a feedback mechanism for driving sawtooth events. However, observational evidence[4,5] suggest that the presence of O+ in the plasma sheet is neither necessary nor sufficient. In this study we investigate whether the solar wind driver of the geomagnetic storm has an effect on the result. Building on an earlier study[4] that used events for which Cluster data is available in the plasma sheet and boundary layer, we perform a superposed epoch analysis for coronal mass ejection (CME) driven storms and streaming interaction region (SIR) driven storms separately, to investigate the hypothesis that ionospheric O+ is an important contributor for CME-driven storms but not SIR-driven storms[2]. [1]O. J. Brambles et al. (2011), Science 332, 1183.[2]O. J. Brambles et al. (2013), JGR 118, 6026.[3]R. H. Varney et al. (2016), JGR 121, 9688.[4]J. Liao et al. (2014), JGR 119, 1572.[5]E. J. Lund et al. (2017), JGR, submitted.

Southeast Asia Report.

Science.gov (United States)

1984-03-22

ankle boots and a fashJ™£^BMrt Tod^Ŝ f^f ^ht Jean*» M*h- draped in a white purdah, a robe which 1^ fl *** delicate fig"re is posed. She is...voters. It is a crack in Sir Robert’s armour which the New Zealand Party continues to exploit. Backbench Third, there is the un- answered question

Book Reviews

Directory of Open Access Journals (Sweden)

John Bastin

1957-10-01

Full Text Available - P.E. de Josselin de Jong, Philip Lumban Tobing, The structure of the Toba-Batak belief in the high God. Amsterdam (Jacob van Campen 1956. (Diss. Utrecht. 177 pp., map, plates, bibl. - R. Reinsma, John Bastin, The native policies of Sir Stamford Raffles in Java and Sumatra. An Economic Interpretation, Clarendon Press: Oxford University Press, 1957; 163 blz. - A.F.P. Hulsewé, Lindsay Ride, Robert Morrison, the scholar and the man, and illustrated catalogue of the exhibition held at the University of Hongkong...to commemorate the 150th anniversary of Robert Morrison’s arrival in China; Hongkong, 1957. VIII + 48 + 24 +pp.

Dynamical Analysis of SIR Epidemic Models with Distributed Delay

Directory of Open Access Journals (Sweden)

Wencai Zhao

2013-01-01

Full Text Available SIR epidemic models with distributed delay are proposed. Firstly, the dynamical behaviors of the model without vaccination are studied. Using the Jacobian matrix, the stability of the equilibrium points of the system without vaccination is analyzed. The basic reproduction number R is got. In order to study the important role of vaccination to prevent diseases, the model with distributed delay under impulsive vaccination is formulated. And the sufficient conditions of globally asymptotic stability of “infection-free” periodic solution and the permanence of the model are obtained by using Floquet’s theorem, small-amplitude perturbation skills, and comparison theorem. Lastly, numerical simulation is presented to illustrate our main conclusions that vaccination has significant effects on the dynamical behaviors of the model. The results can provide effective tactic basis for the practical infectious disease prevention.

Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine.

Science.gov (United States)

McILwain, R Britt; Timpa, Joseph G; Kurundkar, Ashish R; Holt, David W; Kelly, David R; Hartman, Yolanda E; Neel, Mary Lauren; Karnatak, Rajendra K; Schelonka, Robert L; Anantharamaiah, G M; Killingsworth, Cheryl R; Maheshwari, Akhil

2010-01-01

Extracorporeal membrane oxygenation (ECMO) is a life-saving support system used in neonates and young children with severe cardiorespiratory failure. Although ECMO has reduced mortality in these critically ill patients, almost all patients treated with ECMO develop a systemic inflammatory response syndrome (SIRS) characterized by a 'cytokine storm', leukocyte activation, and multisystem organ dysfunction. We used a neonatal porcine model of ECMO to investigate whether rising plasma concentrations of inflammatory cytokines during ECMO reflect de novo synthesis of these mediators in inflamed tissues, and therefore, can be used to assess the severity of ECMO-related SIRS. Previously healthy piglets (3-week-old) were subjected to venoarterial ECMO for up to 8 h. SIRS was assessed by histopathological analysis, measurement of neutrophil activation (flow cytometry), plasma cytokine concentrations (enzyme immunoassays), and tissue expression of inflammatory genes (PCR/western blots). Mast cell degranulation was investigated by measurement of plasma tryptase activity. Porcine neonatal ECMO was associated with systemic inflammatory changes similar to those seen in human neonates. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) concentrations rose rapidly during the first 2 h of ECMO, faster than the tissue expression of these cytokines. ECMO was associated with increased plasma mast cell tryptase activity, indicating that increased plasma concentrations of inflammatory cytokines during ECMO may result from mast cell degranulation and associated release of preformed cytokines stored in mast cells. TNF-alpha and IL-8 concentrations rose faster in plasma than in the peripheral tissues during ECMO, indicating that rising plasma levels of these cytokines immediately after the initiation of ECMO may not reflect increasing tissue synthesis of these cytokines. Mobilization of preformed cellular stores of inflammatory cytokines such as in mucosal mast cells may have

Estudo de dois mapas do geógrafo Robert de Vaugondy relativos ao Reino de Portugal do Século XVIII (1751

Directory of Open Access Journals (Sweden)

Marco Pais Neves dos Santos

2013-07-01

Full Text Available Analisamos dois mapas alusivos ao reino de Portugal, datados de 1751, publicados em Paris e assinados pelo geógrafo Robert de Vaugondy, a saber: Partie Septentrionale du Royaume de Portugal, par le Sr. Robert, Geographe ordinaire du Roy. Avec Privilege. 1751. e Partie Meridionale du Royaume de Portugal, par le Sr. Robert, Geographe ordinaire du Roy. Avec Privilege. 1751., com o objetivo de propor uma explicação para as divisões administrativas cartografadas. Como suporte ao objeto do trabalho, caracterizamos de forma concisa a evolução dos limites administrativos do reino de Portugal, desde a sua formação até a atualidade, e abordamos a vida e obra de Robert de Vaugondy. Concluímos ser o mais consentâneo com a lógica representarem divisões eclesiásticas.

Problem in Two Unknowns: Robert Hooke and a Worm in Newton's Apple.

Science.gov (United States)

Weinstock, Robert

1992-01-01

Discusses the place that Robert Hooke has in science history versus the scientific contributions he made. Examines the relationship between Hooke and his contemporary, Isaac Newton, and Hooke's claims that Newton built on his ideas without receiving Newton's recognition. (26 references) (MDH)

Analysis of Active Lava Flows on Kilauea Volcano, Hawaii, Using SIR-C Radar Correlation Measurements

Science.gov (United States)

Zebker, H. A.; Rosen, P.; Hensley, S.; Mouginis-Mark, P. J.

1995-01-01

Precise eruption rates of active pahoehoe lava flows on Kilauea volcano, Hawaii, have been determined using spaceborne radar data acquired by the Space Shuttle Imaging Radar-C (SIR-C). Measurement of the rate of lava flow advance, and the determination of the volume of new material erupted in a given period of time, are among the most important observations that can be made when studying a volcano.

Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2.

Science.gov (United States)

Bheda, Poonam; Swatkoski, Stephen; Fiedler, Katherine L; Boeke, Jef D; Cotter, Robert J; Wolberger, Cynthia

2012-04-17

Although the biological roles of many members of the sirtuin family of lysine deacetylases have been well characterized, a broader understanding of their role in biology is limited by the challenges in identifying new substrates. We present here an in vitro method that combines biotinylation and mass spectrometry (MS) to identify substrates deacetylated by sirtuins. The method permits labeling of deacetylated residues with amine-reactive biotin on the ε-nitrogen of lysine. The biotin can be utilized to purify the substrate and identify the deacetylated lysine by MS. The biotinyl-lysine method was used to compare deacetylation of chemically acetylated histones by the yeast sirtuins, Sir2 and Hst2. Intriguingly, Sir2 preferentially deacetylates histone H3 lysine 79 as compared to Hst2. Although acetylation of K79 was not previously reported in Saccharomyces cerevisiae, we demonstrate that a minor population of this residue is indeed acetylated in vivo and show that Sir2, and not Hst2, regulates the acetylation state of H3 lysine 79. The in vitro biotinyl-lysine method combined with chemical acetylation made it possible to identify this previously unknown, low-abundance histone acetyl modification in vivo. This method has further potential to identify novel sirtuin deacetylation substrates in whole cell extracts, enabling large-scale screens for new deacetylase substrates.

The importance of chromosome studies in Roberts syndrome/SC phocomelia and other cohesinopathies.

NARCIS (Netherlands)

Gerkes, E.H.; Kevie-Kersemaekers, A.M. van der; Yakin, M.; Smeets, D.F.C.M.; Ravenswaaij-Arts, C.M.A. van

2010-01-01

Roberts syndrome/SC phocomelia is a rare, autosomal recessive syndrome characterised by pre- and postnatal growth retardation, microcephaly, craniofacial anomalies, mental retardation, and tetraphocomelia in varying degrees of severity. The clinical diagnosis can be challenging in phenotypically

The importance of chromosome studies in Roberts syndrome/SC phocomelia and other cohesinopathies

NARCIS (Netherlands)

Gerkes, Erica H.; van der Kevie-Kersemaekers, Anne-Marie F.; Yakin, Mariam; Smeets, Dominique F. C. M.; van Ravenswaaij-Arts, Conny M. A.

2010-01-01

Roberts syndrome/SC phocomelia is a rare, autosomal recessive syndrome characterised by pre- and postnatal growth retardation, microcephaly, craniofacial anomalies, mental retardation, and tetraphocomelia in varying degrees of severity. The clinical diagnosis can be challenging in phenotypically

A stochastic SIRS epidemic model with infectious force under intervention strategies

Science.gov (United States)

Cai, Yongli; Kang, Yun; Banerjee, Malay; Wang, Weiming

2015-12-01

In this paper, we extend a classical SIRS epidemic model with the infectious forces under intervention strategies from a deterministic framework to a stochastic differential equation (SDE) one through introducing random fluctuations. The value of our study lies in two aspects. Mathematically, by using the Markov semigroups theory, we prove that the reproduction number R0S can be used to govern the stochastic dynamics of SDE model. If R0S 1, under mild extra conditions, it has an endemic stationary distribution which leads to the stochastical persistence of the disease. Epidemiologically, we find that random fluctuations can suppress disease outbreak, which can provide us some useful control strategies to regulate disease dynamics.

Sir Charles Bell (1774-1842) and his contributions to early neurosurgery.

Science.gov (United States)

Tubbs, R Shane; Riech, Sheryl; Verma, Ketan; Mortazavi, Martin M; Loukas, Marios; Benninger, Brion; Cohen-Gadol, Aaron A

2012-03-01

The renowned surgeon, neuroanatomist, and artist Sir Charles Bell not only impacted the lives of his peers through his creative endeavors and passion for art, but also sparked noteworthy breakthroughs in the field of neuroscience. His empathetic nature and zest for life enabled him to develop an early proclivity for patient care. As a result of his innovative findings regarding sensory and motor nerves and the anatomical makeup of the brain, he accepted some of the most prestigious awards and received an honorable reputation in society. Bell is recognized for his diligence, perseverance, and his remarkable contributions to surgery. The present review will explore his contributions to the discipline now known as neurosurgery.

Maurice Couturier. Nabokov ou la cruauté du désir.

Directory of Open Access Journals (Sweden)

René Alladaye

2006-04-01

Full Text Available La lecture peut avoir partie liée avec la transgression. Maurice Couturier en apporte la preuve dans son dernier ouvrage, Nabokov ou la cruauté du désir, en enfreignant l’un des plus célèbres interdits nabokoviens, celui de la lecture psychanalytique de son œuvre. On se souvient des préfaces des romans où l’auteur ne se fait jamais faute de décourager la moindre velléité freudienne et d’une réponse des plus tranchantes administrée dans le cadre d’un entretien : « Laissons les crédules et les ...

Robert Aymar awarded the Légion d’honneur

CERN Multimedia

CERN Bulletin

2011-01-01

  On 24 May, Robert Aymar, CERN Director-General from 2004 to 2008, was awarded the Légion d’honneur by the French authorities in recognition of his outstanding scientific career. A renowned French physicist, he was Director of the superconducting tokamak Tore Supra from 1977 to 1988, Director of Material Sciences at the CEA in 1990 and Director of the ITER project in 1994. His term of office as CERN Director-General was marked in particular by the commissioning and start-up of the LHC machine, which he inaugurated on 21 October 2008.        

Robert Hooke, inventor of the vacuum pump and the first altitude chamber (1671).

Science.gov (United States)

Harsch, Viktor

2006-08-01

Robert Hooke (1635-1703), an assistant researcher to Robert Boyle (1627-1691), invented the first functional British air pump. Applying it to scientific research, Hooke operated the world's first hypobaric chamber in 1671, using it for self-experimentation. He recorded the first physiological observations in an artificial altitude-equivalent environment up to 2400 m. Though Hooke's experiment showed some methodological insufficiencies, his imaginative experimental techniques were remarkable for their time and were indicative of the lively intellectual atmosphere of the Royal Society and the significant contributions of Hooke, who was a member. Two centuries passed before the French physiologist Paul Bert (1830-1886) conducted his famous laboratory-supported investigations of high altitude physiology. Bert played a decisive role in the discovery of the causes of decompression sickness; a contribution Hooke could not make due to the technical deficiencies of the 17th century.

Genes ycfR, sirA and yigG contribute to the surface attachment of Salmonella enterica Typhimurium and Saintpaul to fresh produce.

Directory of Open Access Journals (Sweden)

Joelle K Salazar

Full Text Available Salmonella enterica is a frequent contaminant of minimally-processed fresh produce linked to major foodborne disease outbreaks. The molecular mechanisms underlying the association of this enteric pathogen with fresh produce remain largely unexplored. In our recent study, we showed that the expression of a putative stress regulatory gene, ycfR, was significantly induced in S. enterica upon exposure to chlorine treatment, a common industrial practice for washing and decontaminating fresh produce during minimal processing. Two additional genes, sirA involved in S. enterica biofilm formation and yigG of unknown function, were also found to be differentially regulated under chlorine stress. To further characterize the roles of ycfR, sirA, and yigG in S. enterica attachment and survival on fresh produce, we constructed in-frame deletions of all three genes in two different S. enterica serovars, Typhimurium and Saintpaul, which have been implicated in previous disease outbreaks linked to fresh produce. Bacterial attachment to glass and polystyrene microtiter plates, cell aggregation and hydrophobicity, chlorine resistance, and surface attachment to intact spinach leaf and grape tomato were compared among wild-type strains, single-gene deletion mutants, and their respective complementation mutants. The results showed that deletions of ycfR, sirA, and yigG reduced bacterial attachment to glass and polystyrene as well as fresh produce surface with or without chlorine treatment in both Typhimurium and Saintpaul. Deletion of ycfR in Typhimurium significantly reduced bacterial chlorine resistance and the attachment to the plant surfaces after chlorinated water washes. Deletions of ycfR in Typhimurium and yigG in Saintpaul resulted in significant increase in cell aggregation. Our findings suggest that ycfR, sirA, and yigG collectively contribute to S. enterica surface attachment and survival during post-harvest minimal processing of fresh produce.

Hodorkovski advokaat : Venemaa ei ole õigusriik / Robert R. Amsterdam ; interv. Aleksei Günter

Index Scriptorium Estoniae

Amsterdam, Robert R.

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke 24. juuli lk. 10. Naftamagnaadi Mihhail Hodorkovski advokaat vastab küsimustele, mis puudutavad ärimehe olukorda ja elamistingimusi vanglas ning tema võimalust ennetähtaegselt vabaneda. Lisa: Robert R. Amsterdam

An Environment for Treating Youthful Offenders: The Robert F. Kennedy Youth Center

Science.gov (United States)

Johnson, V. Scott

1977-01-01

Describes goals of the Robert F. Kennedy Youth Center (KYC) and the philosophical stance and the implementation of that philosophy within the center. Issues discussed range from administrative structure through descriptions of inmate classification and treatment. Educational and vocational programs as well as the token economy systems are…

Saksa filmilootusega tänavaelust ja hullusest / Robert Stadlober ; interv. Janno Zõbin

Index Scriptorium Estoniae

Stadlober, Robert

2002-01-01

Pimedate Ööde Filmifestivalil näidatud saksa mängufilmis "Engel & Joe" (režissöör Vanessa Jopp) ühes peaosas esines festivali külastanud saksa näitleja Robert Stadlober (1982). Näitleja Engeli rollist ja oma elukogemusest, mis aitas seda rolli kehastada

American Community Colleges in Crisis--A Conversation with Robert H. McCabe.

Science.gov (United States)

Dubocq, Tom

1981-01-01

Educational reform by Miami-Dade Community College is discussed by its president, Robert H. McCabe. In an action that is considered unusual for two-year schools, it has tightened controls on its curriculum, faculty, and students. A commitment to achieving higher levels of literacy is advocated. (MLW)

Looking Forward: Texas and Its Elderly. Highlights of the Robert Lee Sutherland Seminar (4th, Austin, Texas, May 12, 1984).

Science.gov (United States)

Coleman, Marion Tolbert, Ed.; And Others

This document presents the program agenda and highlights from the one-day Robert Lee Sutherland Seminar held to examine the current status and the future of the elderly population of Texas. Included is the speech, "The Longevity Revolution" by Robert N. Butler, in which is discussed the gain in life expectancy, the feminization of aging,…

78 FR 51802 - Culturally Significant Objects Imported for Exhibition Determinations: “Robert Motherwell: The...

Science.gov (United States)

2013-08-21

... ``Robert Motherwell: The Early Collages,'' imported from abroad for temporary exhibition within the United... the Solomon R. Guggenheim Museum, New York, New York, from on or about September 27, 2013, until on or...

Robert Priddle talking straight

International Nuclear Information System (INIS)

Anon

2000-01-01

A keynote speaker at Outlook 2001 conference, Robert Priddle, Executive Director of the International Energy Agency, provided a realistic assessment of the opportunities for a change in the energy supply mix in the light of the growing international debate about the design of a sustainable energy future. World energy supply today is based firmly on fossil fuels. Furthermore, projections of future supply, such as that made in the reference case of the recent World Energy Outlook by the IEA, indicate little change. Yet government's remain deeply engaged in efforts to reshape energy markets including (despite the failure of COP-6 in The Hague last November) efforts to curb national emissions of greenhouse gases, in particular from the energy sector. Australia has made considerable progress in developing and applying life cycle analysis to the energy sector. This effort demonstrates opportunities to combine, for example, coal seam methane capture, coal and biomass co-combustion, coal power generation and steel production and thus to reduce emissions by up to 15%. The prospect is that even with effective carbon constraints reflected in fuel prices, coal can remain a competitive fuel choice for longer than many analysts imagine. The outcome does not rely on exotic technology development, rather it requires the necessary market signals to create new business partnerships

Robert Owen: A Historiographic Study of a Pioneer of Human Resource Development

Science.gov (United States)

Hatcher, Tim

2013-01-01

Purpose: The purpose of this paper is to investigate the ideals and activities of the nineteenth century Welsh industrialist and reformer Robert Owen (1771-1858), and how they informed modern human resource development (HRD) concepts and practices and provided evidence of Owen as a HRD pioneer. Design/methodology/approach: Historiography provided…

Research, Learning Theory, and the Ideas of Robert G. Sidnell. Special Issue.

Science.gov (United States)

Alexander, David, Ed.; And Others

1987-01-01

Intended as a memorial to Robert G. Sidnell, this special issue contains articles about areas of music education which he promoted. In "The Dimensions of Research in Music Education," Sidnell concluded that music education research encompasses all humanistic disciplines as well as the behavioral and social sciences. James Carlsen, in…

Global stability of an SIR model with differential infectivity on complex networks

Science.gov (United States)

Yuan, Xinpeng; Wang, Fang; Xue, Yakui; Liu, Maoxing

2018-06-01

In this paper, an SIR model with birth and death on complex networks is analyzed, where infected individuals are divided into m groups according to their infection and contact between human is treated as a scale-free social network. We obtain the basic reproduction number R0 as well as the effects of various immunization schemes. The results indicate that the disease-free equilibrium is locally and globally asymptotically stable in some conditions, otherwise disease-free equilibrium is unstable and exists an unique endemic equilibrium that is globally asymptotically stable. Our theoretical results are confirmed by numerical simulations and a promising way for infectious diseases control is suggested.

The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity

NARCIS (Netherlands)

Gordillo, Miriam; Vega, Hugo; Trainer, Alison H.; Hou, Fajian; Sakai, Norio; Luque, Ricardo; Kayserili, Hülya; Basaran, Seher; Skovby, Flemming; Hennekam, Raoul C. M.; Uzielli, Maria L. Giovannucci; Schnur, Rhonda E.; Manouvrier, Sylvie; Chang, Susan; Blair, Edward; Hurst, Jane A.; Forzano, Francesca; Meins, Moritz; Simola, Kalle O. J.; Raas-Rothschild, Annick; Schultz, Roger A.; McDaniel, Lisa D.; Ozono, Keiichi; Inui, Koji; Zou, Hui; Jabs, Ethylin Wang

2008-01-01

Roberts syndrome/SC phocomelia (RBS) is an autosomal recessive disorder with growth retardation, craniofacial abnormalities and limb reduction. Cellular alterations in RBS include lack of cohesion at the heterochromatic regions around centromeres and the long arm of the Y chromosome, reduced growth

Using Performance as an Interpretive Strategy in Teaching Robert Browning's "My Last Duchess."

Science.gov (United States)

Schevera, Nicholas

1997-01-01

Uses role-playing, dramatic monologues, and "tableaux vivant" to interpret Robert Browning's poem "My Last Duchess" in an introductory literature class at Westchester Community College. Notes that performative strategies illustrate connections in the poem that often remain unnoticed on a first reading. (PA)

[Sir Arthur Conan Doyle, Sherlock Holmes and infectious diseases].

Science.gov (United States)

Ledermann D, Walter

2010-10-01

Besides a pleasant author of best sellers, Sir Arthur Conan Doyle was a medical doctor, writing excellent short stories about the exercise of his profession in England. However, even he mentions The British Medical Journal and The Lancet in the Sherlock Holmes's stories, when in the plot introduces infectious diseases, Conan Doyle ignores important discoveries in the field of tetanus. Anyway, the appearing of infectious diseases in the adventures of the detective are rare: one mention of tetanus, another of leprosy and- the most analyzed in medical literature a case of murder by inoculation of bacteria, probably the agent of melioidosis. Also he makes his hero discovers the toxic actions of a medusa and a transplant of solid organ. Little for a physician and less for an author who also wrote science fiction: it seems that the history of the great medical discoveries at the end of nineteenth century and beginning of the twentieth has passed by his side.., and he just couldn't see it.

The strange trial of Robert Oppenheimer

International Nuclear Information System (INIS)

Kevles, D.J.

2004-01-01

Robert Oppenheimer has become the symbol of the scientist tormented and anguished by the consequences of his discoveries. R.Oppenheimer took a major part in the Manhattan project for the designing of the first atomic bomb. During this period he considered the thermonuclear bomb as the next step to reach but after Japan's surrender he reconsidered his position and favoured a more moderate atomic policy. R.Oppenheimer began to militate in favour of an international control of nuclear energy and wanted that Usa relinquish to design the hydrogen bomb. In 1953 in full Mac-Carthysm era, he was accused of being a communist and of spying for Ussr and as a consequence he was deprived of his office in AEC (atomic energy committee) but in 1963 president Lyndon Johnson rehabilitated him and R.Oppenheimer was awarded the highest reward of AEC: the Enrico Fermi prize. (A.C.)

Summary Robert Noyce and the invention of Silicon Valley

CERN Document Server

2014-01-01

This work offers a summary of the book "THE MAN BEHIND THE MICROCHIP: Robert Noyce and the Invention of Silicon Valley""by Leslie Berlin.The Man behind the Microchip is Leslie Berlin's first book. This author is project historian for the Silicon Valley Archives, a division of the Stanford University Department of Special Collections. This book tells the story of a giant of the high-tech industry: the multimillionaire Bob Noyce. This co-founder of Fairchild Semiconductor and Intel co-invented the integrated circuit which became the electronic heart of every modern computer, automobile, advance

Robert Wiltrout Says Goodbye to NCI in 2015 | Poster

Science.gov (United States)

After 34 years at NCI, Robert Wiltrout, Ph.D., said he is looking forward to trading his I-270 commute for another type of commute: exploring the waterways of Maryland, Alaska, and Wyoming to fulfill his love of fishing. Wiltrout officially retired as director of the NCI Center for Cancer Research (CCR) on July 2 of last year. Throughout his college academic career, Wiltrout had an interest in science, but it was not until he was working on a research project for his master’s degree that he considered a career in scientific research.

Different strategies of osmoadaptation in the closely related marine myxobacteria Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1.

Science.gov (United States)

Amiri Moghaddam, Jamshid; Boehringer, Nils; Burdziak, Amal; Kunte, Hans-Jörg; Galinski, Erwin A; Schäberle, Till F

2016-02-03

Only a few myxobacteria are known to date which are classified as marine due to their salt-dependency. In this study, the salt tolerance mechanism of these bacteria was investigated. Therefore, a growth medium was designed, in which the mutated Escherichia coli strain BKA13 served as sole food source for the predatory, heterotrophic myxobacteria. This enabled measurement of the osmolytes without any background and revealed that the closely related strains Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1 developed different strategies to handle salt stress. P. pacifica SIR-1, which was grown between 1-4 % NaCl, relies solely on the accumulation of amino acids, while E. salina SWB007, which was grown between 0.5-3 % NaCl, employs, beside betaine, hydroxyectoine as the major compatible solute. In accordance with this analysis, only in the latter strain a gene locus was identified which codes for genes corresponding to the biosynthesis of betaine, ectoine, and hydroxyectoine.

Welcoming the Sunlight: A Conversation with Mary Kay Zabel and Robert Zabel

Science.gov (United States)

Teagarden, James; Kaff, Marilyn

2018-01-01

Professors Emeriti Mary Kay and Robert Zabel share their reflections on their long and productive careers working with students and teachers. Their respective careers share much of the same history and complement each other. The Zabels share their advice with those entering the field and the challenges they see for the education of students with…

The scientific careers of Robert Sinclair and Nestor Zaluzec - A brief sketch

Energy Technology Data Exchange (ETDEWEB)

Fraser, Hamish L. [The Ohio State University (United States); Smith, David J., E-mail: david.smith@asu.edu [Arizona State University (United States); Wittig, James E. [Vanderbilt University (United States)

2017-05-15

Robert (Bob) Sinclair and Nestor Zaluzec have been working for many years at the leading edge of developments in electron microscopy techniques and applications. Their distinguished careers and some of their notable scientific achievements are briefly highlighted. - Highlights: • Biographical sketch of Bob Sinclair • Biographical Sketch of Nestor Zaluzec • Scientific career highlights.

The scientific careers of Robert Sinclair and Nestor Zaluzec - A brief sketch

International Nuclear Information System (INIS)

Fraser, Hamish L.; Smith, David J.; Wittig, James E.

2017-01-01

Robert (Bob) Sinclair and Nestor Zaluzec have been working for many years at the leading edge of developments in electron microscopy techniques and applications. Their distinguished careers and some of their notable scientific achievements are briefly highlighted. - Highlights: • Biographical sketch of Bob Sinclair • Biographical Sketch of Nestor Zaluzec • Scientific career highlights

Deforestation and Secondary Growth in Rondonia, Brazil from SIR-C SAR and Landsat.SPOT data

Science.gov (United States)

Rignot, Eric; Salas, William A.; Skole, David L.

1996-01-01

Covers problems with existing data collected with high-resolution optical sensors. They say active microwave sensors could complement other sensors in getting through things like cloud cover. They analyzed SIR-C data in combination with Landsat TM data, a 9-year time series of SPOT XS data, and a preliminary field survey. They report findings and draw conclusions, including that SARs operating at long radar wavelengths, with both like and cross-polarizations, are needed for tropical deforestation studies.

Increased extracellular heat shock protein 90α in severe sepsis and SIRS associated with multiple organ failure and related to acute inflammatory-metabolic stress response in children.

Science.gov (United States)

Fitrolaki, Michaela-Diana; Dimitriou, Helen; Venihaki, Maria; Katrinaki, Marianna; Ilia, Stavroula; Briassoulis, George

2016-08-01

Mammalian heat-shock-protein (HSP) 90α rapidly responses to environmental insults. We examined the hypothesis that not only serum HSP72 but also HSP90α is increased in the systemic inflammatory response syndrome (SIRS), severe-sepsis (SS), and/or sepsis (S) compared to healthy children (H); we assessed HSP90α relation to (a) multiple organ system failure (MOSF) and (b) inflammatory-metabolic response and severity of illness.A total of 65 children with S, SS, or SIRS and 25 H were included. ELISA was used to evaluate extracellular HSP90α and HSP72, chemiluminescence interleukins (ILs), flow-cytometry neutrophil-CD64 (nCD64)-expression.HSP90α, along with HSP72, were dramatically increased among MOSF patients. Patients in septic groups and SIRS had elevated HSP90α compared to H (P stress, fever, outcome endpoints, and predicted mortality and inversely related to the low-LDL/low-HDL stress metabolic pattern.

Sir Francis Joseph Campbell and His Family: The First Family in Professional Services for People Who Are Blind or Visually Impaired

Science.gov (United States)

Welsh, Richard L.

2008-01-01

The author discusses the pivotal roles of Sir Francis Campbell (1832-1914) and members of his family, especially his son Charles Campbell, in the evolution of the blindness field to a professional and reason-based service.

Tim, Jan Lucas ja Karl Robert - vennad üheks kuuks / Maris Laurits

Index Scriptorium Estoniae

Laurits, Maris

2009-01-01

Rakvere Teatri suvelavastuse "Vennad Lõvisüdamed" kaks Karli osatäitjat Jan Lucas Videvik ja Tim Leesnurm ning Joonatani osatäitja Karl Robert Saaremäe tegid Loksal Kaldmaa talus ratsasõiduproove. Üllar Saaremäe lavastuse "Vennad Lõvisüdamed" (Astrid Lindgreni samanimelise jutustuse järgi) esietendus on 11. juunil Rakvere teatri taga aias

The Revision of FM 3-24 is Overdue: Rethinking Classical Counterinsurgency to Defeat Contemporary Insurgents

Science.gov (United States)

2011-06-17

in the 1950s and 1960s, in particular, French officer David Galula and British officer Sir Robert Thompson, respectively. Contemporary experts are...relates to its heavy reliance on examples provided from the “ glorious heyday of revolutionary warfare” between 1950 and 1970 where Thompson and Galula... food supplies after the harvest to ensure that it is distributed effectively over the year until the next harvest. This is an important

Why UW: Factoring in the Decision Point for Unconventional Warfare

Science.gov (United States)

2012-12-01

1917. Sir Percy Molesworth Sykes, A History of Persia, Volume 2, (Charleston SC: Nabu Press, 2011), 478. 45 The Russo-Iranian Friendship Treaty was...support for resistance groups.67 Later, the National Security Council organized the Dulles- Jackson -Correa committee to study CIA operations and the...prison sentence. Eventually, a conditional release was granted on September 23, 2011. Robert Jackson , LA Times, “Noriega Gets 40 Years in Prison

Ut Pictura Poesis : dialéctica entre palabras e imagen en Sir William Sterling Maxwell

Directory of Open Access Journals (Sweden)

Hilary Macartney

2002-01-01

Full Text Available En el presente artículo se analiza la estrecha relación entre la historia del arte de Sir William Stirling Maxwell, su biblioteca y su colección artística. Este vínculo encierra la clave para la comprensión de su excepcional aportación a la historiografía del arte español. Sus diversas actividades, como historiador del arte, coleccionista de libros y cuadros, y director de ediciones privadas de libros raros, fueron todas manifestaciones de su gran fascinación por el paralelo entre la literatura y el arte, la palabra y la imagen. Tal relación se encuentra incluso en el esquema decorativo de su biblioteca.This article examines the remarkable unity between Sir William Stirling Maxwell's art history, his library and his art collection and argües that this relationship is the key to understanding his unique contribution to scholarship of Spanish art. In particular, it will be shown that his actlvities as an art historian, bibliophile, art collector and editor of prívate editions of rare books were all expressions of his fascination with the relationship between literature and art in general, and more specifically between word and image. Even the decorative scheme of his library emphasised this relationship.

A mixed SIR-SIS model to contain a virus spreading through networks with two degrees

Science.gov (United States)

Essouifi, Mohamed; Achahbar, Abdelfattah

Due to the fact that the “nodes” and “links” of real networks are heterogeneous, to model computer viruses prevalence throughout the Internet, we borrow the idea of the reduced scale free network which was introduced recently. The purpose of this paper is to extend the previous deterministic two subchains of Susceptible-Infected-Susceptible (SIS) model into a mixed Susceptible-Infected-Recovered and Susceptible-Infected-Susceptible (SIR-SIS) model to contain the computer virus spreading over networks with two degrees. Moreover, we develop its stochastic counterpart. Due to the high protection and security taken for hubs class, we suggest to treat it by using SIR epidemic model rather than the SIS one. The analytical study reveals that the proposed model admits a stable viral equilibrium. Thus, it is shown numerically that the mean dynamic behavior of the stochastic model is in agreement with the deterministic one. Unlike the infection densities i2 and i which both tend to a viral equilibrium for both approaches as in the previous study, i1 tends to the virus-free equilibrium. Furthermore, since a proportion of infectives are recovered, the global infection density i is minimized. Therefore, the permanent presence of viruses in the network due to the lower-degree nodes class. Many suggestions are put forward for containing viruses propagation and minimizing their damages.

Robert Lévy-Mandel (1923-2010)

CERN Multimedia

2010-01-01

Former CERN Director Robert Lévy-Mandel passed away on 3 July at the age of 87.   After obtaining a diploma from the Institut polytechnique in Grenoble, in 1948 he started work at the CEA, and was involved in the development and construction of the Saclay institute's first particle accelerator, a Van de Graaff machine. From 1954 to 1957 he was responsible for the coordination, development and construction of the CEA’s Saturne synchrotron, which entered service in 1958. In 1963 he was appointed head of the Saturne Synchrotron Department. The team led the construction of the Gargamelle bubble chamber, which was installed at CERN, and made contributions to other major facilities, including the Big European Bubble Chamber (BEBC). In 1971 he was invited to come to Geneva by John Adams, who was in charge of the SPS accelerator project. With the start of the SPS project, CERN had two laboratories, one at Meyrin and one at Prévessin, each with its own Director General: ...

Filtering authentic sepsis arising in the ICU using administrative codes coupled to a SIRS screening protocol.

Science.gov (United States)

Sudduth, Christopher L; Overton, Elizabeth C; Lyu, Peter F; Rimawi, Ramzy H; Buchman, Timothy G

2017-06-01

Using administrative codes and minimal physiologic and laboratory data, we sought a high-specificity identification strategy for patients whose sepsis initially appeared during their ICU stay. We studied all patients discharged from an academic hospital between September 1, 2013 and October 31, 2014. Administrative codes and minimal physiologic and laboratory criteria were used to identify patients at high risk of developing the onset of sepsis in the ICU. Two clinicians then independently reviewed the patient record to verify that the screened-in patients appeared to become septic during their ICU admission. Clinical chart review verified sepsis in 437/466 ICU stays (93.8%). Of these 437 encounters, only 151 (34.6%) were admitted to the ICU with neither SIRS nor evidence of infection and therefore appeared to become septic during their ICU stay. Selected administrative codes coupled to SIRS criteria and applied to patients admitted to ICU can yield up to 94% authentic sepsis patients. However, only 1/3 of patients thus identified appeared to become septic during their ICU stay. Studies that depend on high-intensity monitoring for description of the time course of sepsis require clinician review and verification that sepsis initially appeared during the monitoring period. Copyright © 2017 Elsevier Inc. All rights reserved.

Threshold Dynamics in Stochastic SIRS Epidemic Models with Nonlinear Incidence and Vaccination

Directory of Open Access Journals (Sweden)

Lei Wang

2017-01-01

Full Text Available In this paper, the dynamical behaviors for a stochastic SIRS epidemic model with nonlinear incidence and vaccination are investigated. In the models, the disease transmission coefficient and the removal rates are all affected by noise. Some new basic properties of the models are found. Applying these properties, we establish a series of new threshold conditions on the stochastically exponential extinction, stochastic persistence, and permanence in the mean of the disease with probability one for the models. Furthermore, we obtain a sufficient condition on the existence of unique stationary distribution for the model. Finally, a series of numerical examples are introduced to illustrate our main theoretical results and some conjectures are further proposed.

Robert Musil y los Estados desunificados de Europa

Directory of Open Access Journals (Sweden)

Bayón, Fernando

2006-12-01

Full Text Available This article is a study of Robert Musil´s work “The Man Without Qualities” from philosophical sources. It is a novel that has produced so many overriding metaphors through which we can better understand the crises of the social identity on the horizont of the last modernity in Europe. Much of the key-concepts that helped in creating the so called “Leyend of Modernity” start to vanish in an irremediable way: not only did Musil trace the disappearance of the support for national aspirations and social cohesion, he also showed us how culture is a mad carrousel of collapsed expectations, and how the prevailing idea of “subjectivity” lacks today any solid or essential nucleus. In the middle of this disenchanted landscape of Europe, where all the modern and clasical illusions became nothing, appears however “a new human being”, since the man “without qualities” is the man with endless possibilities too.El presente ensayo es una interpretación de la novela de Robert Musil “El hombre sin atributos” a partir de fuentes filosóficas. Se trata de una obra que ha producido algunas metáforas decisivas para comprender las crisis de la identidad social en el horizonte de la última modernidad europea. Muchos de los conceptos clave que ayudaron a crear la leyenda de la modernidad empiezan a erosionarse de modo irreversible: se descomponen las aspiraciones nacionales, el sujeto pierde su núcleo sustancial y la cultura es un carrusel de esperanzas abortadas incapaces de responder a ninguna idea rectora. Y, sin embargo, en el paisaje de esta Europa tardomoderna en que se han agotado las pasadas ilusiones surge la idea de que el “hombre sin atributos” es también el “hombre de las posibilidades”.

Robert Hooke: early respiratory physiologist, polymath, and mechanical genius.

Science.gov (United States)

West, John B

2014-07-01

Robert Hooke (1635-1703) was a polymath who made important contributions to respiratory physiology and many other scientific areas. With Robert Boyle, he constructed the first air pump that allowed measurements on small animals at a reduced atmospheric pressure, and this started the discipline of high-altitude physiology. He also built the first human low-pressure chamber and described his experiences when the pressure was reduced to the equivalent of an altitude of ∼2,400 m. Using artificial ventilation in an animal preparation, he demonstrated that movement of the lung was not essential for life. His book Micrographia describing early studies with a microscope remains a classic. He produced an exquisite drawing of the head of a fly, showing the elaborate compound eye. There is also a detailed drawing of a flea, and Hooke noted how the long, many-jointed legs enable the insect to jump so high. For 40 years, he was the curator of experiments for the newly founded Royal Society in London and contributed greatly to its intellectual ferment. His mechanical inventions covered an enormous range, including the watch spring, the wheel barometer, and the universal joint. Following the Great Fire of London in 1666, he designed many of the new buildings in conjunction with Christopher Wren. Unfortunately, Hooke had an abrasive personality, which was partly responsible for a lack of recognition of his work for many years. However, during the last 25 years, there has been renewed interest, and he is now recognized as a brilliant scientist and innovator. ©2014 Int. Union Physiol. Sci./Am. Physiol. Soc.

Robert Frazure mälestuspuu Sõpruse pargis sai graniitpotil tähistuse / Raivo Feldmann

Index Scriptorium Estoniae

Feldmann, Raivo

2007-01-01

Esimese USA suursaadiku sõjajärgses Eestis, Robert Frazure' mälestuspuu sai Sõpruse pargis tähise, vajaliku raha ettevõtmise heaks annetasid Ameerika Suursaatkonna töötajad, nende delegatsioon viibis Põltsamaal Sõpruse pargis toimunud üritusel

Improvements to the Understanding of the Fire Performance of Wood over the Past 30 Years-A Tribute to Robert Hawthorne White

Science.gov (United States)

Samuel L. Zelinka; Mark A. Dietenberger; Laura E. Hasburgh; Keith J. Bourne; Charles Boardman

2015-01-01

Dr. Robert Hawthorne White had a 31 year career researching the fire performance of wood and wood composites at the USDA Forest Products Laboratory. Over his career, Dr. White made substantial contributions to codes, standards, and regulations pertaining to the design of wood structures. This review article summarizes Robert’s major accomplishments as a tribute to his...

On pulse vaccine strategy in a periodic stochastic SIR epidemic model

International Nuclear Information System (INIS)

Wang, Fengyan; Wang, Xiaoyi; Zhang, Shuwen; Ding, Changming

2014-01-01

A periodic stochastic SIR epidemic model with pulse vaccination is studied. The system has global positive solutions and under some conditions it admits a unique positive periodic disease-free solution, which is globally exponentially stable in mean square. The mathematical expectation and variance of the positive periodic solution are obtained. Two threshold parameters R 1 and R 2 (R 1 >R 2 ) are identified; if R 1 <1, the susceptible will be persistent in the mean and the disease will go to extinction; if R 2 >1, the susceptible and the disease will be weakly persistent in the mean. We show that by repeatedly vaccinating the susceptible population in series of pulses, it is possible to eradicate the infective from the entire model population in the random environment

Granular statistical mechanics - Building on the legacy of Sir Sam Edwards

Science.gov (United States)

Blumenfeld, Raphael

When Sir Sam Edwards laid down the foundations for the statistical mechanics of jammed granular materials he opened a new field in soft condensed matter and many followed. In this presentation we review briefly the Edwards formalism and some of its less discussed consequences. We point out that the formalism is useful for other classes of systems - cellular and porous materials. A certain shortcoming of the original formalism is then discussed and a modification to overcome it is proposed. Finally, a derivation of an equation of state with the new formalism is presented; the equation of state is analogous to the PVT relation for thermal gases, relating the volume, the boundary stress and measures of the structural and stress fluctuations. NUDT, Changsha, China, Imperial College London, UK, Cambridge University, UK.

Development of Immunopathobiogenesis on SIRS-Sepsis

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A Guntur Hermawan

2009-04-01

Full Text Available Over the past decade, sepsis has been diagnosed according to consensus guidelines established in 1991 as an infection in addition to the symptoms of systemic inflammatory response syndrome (SIRS. In addition to the previous criteria, the 2001 conference added several new diagnostic criteria for sepsis. Of particular interest was the inclusion of the biomarkers procalcitonin (PCT and C-reactive protein (CRP, despite the overall conclusion that it was premature to use biomarkers for sepsis diagnosis. The primary recommendation of the panel was the implementation of the Predisposition, insult Infection, Response, and Organ dysfunction (PIRO.The immune system has traditionally been devided into innate and adaptive components, each of which has a different role and function in defending the host against infectious agents. Stimulation of different TLRs induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also increasing evidence supports an additional critical role for TLRs in orchestrating the development of adaptive immune responses. The superantigens are able to induce toxic shock syndrome and can sometimes cause multiple organ failure via adaptive immune system. The superantigenic activity of the bacterial exotoxins can be attributed to their ability to cross-link major histocompatibility complex class II molecules on antigen-presenting cells outside the peptide groove with T-cell receptors to form a trimolecular complex. This trimolecular interaction leads to uncontrolled release of a number of proinflammatory cytokines. Proinflammatory cytokines especially IFN-γ and TNF-α, the key cytokines causing toxic shock syndrome. KEYWORDS: sepsis, innate immunity, adaptive.

The man behind the microchip Robert Noyce and the invention of Silicon Valley

CERN Document Server

Berlin, Leslie

2005-01-01

Robert Noyce was a brilliant inventor, a leading entrepreneur and a daring risk taker, who piloted his own jets and skied mountains accessible only by helicopter. This book captures not only this colorful individual, but also the vibrant interplay of technology, business, money, politics and culture that defines the Silicon Valley.

USA kaitseminister Robert Gates süüdistas liitlasvägesid oskamatuses / Evelyn Kaldoja

Index Scriptorium Estoniae

Kaldoja, Evelyn, 1980-

2008-01-01

USA kaitseminister Robert Gates väitis ajalehes The Los Angeles Times avaldatud intervjuus, et Lõuna-Afganistani olukord on halvenenud seal võitlevate USA liitlasvägede puuduliku väljaõppe tõttu. Liitlasriikide reageeringuid. Arvamust avaldavad Jaak Aaviksoo, Kaarel Kaas

Changements à la tête du CERN - Robert Aymar aux commandes pour 5 ans.

CERN Multimedia

2003-01-01

"Une nouvelle équipe prendra les rênes du CERN à partir du 1er janvier. Le Francais Robert Aymar, anciennement directeur du Projet de reacteur thermonucleaire experimental international (ITER), dirigera le centre de recherche pour la periode 2004-2008" (1 page).

Cosmic Thing: Astrology, Space Science, and Personal Cartography in Robert Rauschenberg's Autobiography

Science.gov (United States)

Carey, C. L.

2011-06-01

The following paper undertakes an iconographic analysis of Robert Rauschenberg's large scale print, Autobiography (1967). The artist's interest in astronomy and astrology, visual metaphors aligning the body with the cosmos, and the cartographic representation of self are discussed. Autobiography is placed in cultural and historical context with other works by the artist, elaborated as a personal narrative-an alternative to traditional self portraiture.

Photographic Standards for Patients With Facial Palsy and Recommendations by Members of the Sir Charles Bell Society.

Science.gov (United States)

Santosa, Katherine B; Fattah, Adel; Gavilán, Javier; Hadlock, Tessa A; Snyder-Warwick, Alison K

2017-07-01

There is no widely accepted assessment tool or common language used by clinicians caring for patients with facial palsy, making exchange of information challenging. Standardized photography may represent such a language and is imperative for precise exchange of information and comparison of outcomes in this special patient population. To review the literature to evaluate the use of facial photography in the management of patients with facial palsy and to examine the use of photography in documenting facial nerve function among members of the Sir Charles Bell Society-a group of medical professionals dedicated to care of patients with facial palsy. A literature search was performed to review photographic standards in patients with facial palsy. In addition, a cross-sectional survey of members of the Sir Charles Bell Society was conducted to examine use of medical photography in documenting facial nerve function. The literature search and analysis was performed in August and September 2015, and the survey was conducted in August and September 2013. The literature review searched EMBASE, CINAHL, and MEDLINE databases from inception of each database through September 2015. Additional studies were identified by scanning references from relevant studies. Only English-language articles were eligible for inclusion. Articles that discussed patients with facial palsy and outlined photographic guidelines for this patient population were included in the study. The survey was disseminated to the Sir Charles Bell Society members in electronic form. It consisted of 10 questions related to facial grading scales, patient-reported outcome measures, other psychological assessment tools, and photographic and videographic recordings. In total, 393 articles were identified in the literature search, 7 of which fit the inclusion criteria. Six of the 7 articles discussed or proposed views specific to patients with facial palsy. However, none of the articles specifically focused on

Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1.

Science.gov (United States)

Zhao, Xuan; Lu, Lulu; Qi, Yonghao; Li, Miao; Zhou, Lijun

2017-10-01

The naturally occurring anthraquinone emodin has been serving primarily as an anti-bacterial and anti-inflammatory agent. However, little is known about its potential on anti-aging. This investigation examined the effect of emodin on lifespan and focused on its physiological molecular mechanisms in vivo. Using Caenorhabditis elegans (C. elegans) as an animal model, we found emodin could extend lifespan of worms and improve their antioxidant capacity. Our mechanistic studies revealed that emodin might function via insulin/IGF-1 signaling (IIS) pathway involving, specifically the core transcription factor DAF-16. Quantitative RT-PCR results illustrated that emodin up-regulated transcription of DAF-16 target genes which express antioxidants to promote antioxidant capacity and lifespan of worms. In addition, attenuated effect in sir-2.1 mutants suggests that emodin likely functioned in a SIR-2.1-dependent manner. Our study uncovers a novel role of emodin in prolonging lifespan and supports the understanding of emodin being a beneficial dietary supplement.

Homosexual orientation-from nature, not abuse: A critique of Roberts, Glymour, and Koenen (2013).

Science.gov (United States)

Rind, Bruce

2013-11-01

Roberts, Glymour, and Koenen (2013), using instrumental variable models, argued that child abuse causes homosexual orientation, defined in part as any same-sex attractions. Their instruments were various negative family environment factors. In their analyses, they found that child sexual abuse (CSA) was more strongly related to homosexual orientation than non-sexual maltreatment was, especially among males. The present commentary therefore focused on male CSA. It is argued that Roberts et al.'s "abuse model" is incorrect and an alternative is presented. Male homosexual behavior is common in primates and has been common in many human societies, such that an evolved human male homosexual potential, with individual variation, can be assumed. Cultural variation has been strongly influenced by cultural norms. In our society, homosexual expression is rare because it is counternormative. The "counternormativity model" offered here holds that negative family environment weakens normative controls and increases counternormative thinking and behavior, which, in combination with sufficient homosexual potential and relevant, reinforcing experiences, can produce a homosexual orientation. This is a benign or positive model (innate potential plus release and reinforcement), in contrast to Roberts et al.'s negative model (abuse plus emotional compensation or cognitive distortion). The abuse model is criticized for being based on the sexual victimological paradigm, which developed to describe the female experience in rape and incest. This poorly fits the gay male experience, as demonstrated in a brief non-clinical literature review. Validly understanding male homosexuality, it is argued, requires the broad perspective, as employed here.

Color and Contingency in Robert Boyle's Works.

Science.gov (United States)

Baker, Tawrin

2015-01-01

This essay investigates the relationship between color and contingency in Robert Boyle's Experiments and Considerations Touching Colours (1664) and his essays on the unsuccessfulness of experiments in Certain Physiological Essays (1661). In these two works Boyle wrestles with a difficult practical and philosophical problem with experiments, which he calls the problem of contingency. In Touching Colours, the problem of contingency is magnified by the much-debated issue of whether color had any deep epistemic importance. His limited theoretical principle guiding him in Touching Colours, that color is but modified light, further exacerbated the problem. Rather than theory, Boyle often relied on craftsmen, whose mastery of color phenomena was, Boyle mentions, brought about by economic forces, to determine when colors were indicators of important 'inward' properties of substances, and thus to secure a solid foundation for his experimental history of color.

Spontaneous Transient Lateral Thoracic Lung Herniation Resulting in Systemic Inflammatory Response Syndrome (SIRS and Subsequent Contralateral Lung Injury

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Antony Kaliyadan

2011-01-01

Full Text Available Lung herniation is a relatively rare clinical entity that is most commonly either congenital or acquired traumatically. We describe a case of spontaneous lung herniation secondary to acute cough in an obese male smoker complicated by contralateral acute lung injury and systemic inflammatory response syndrome (SIRS. Mechanisms of lung herniation, classification, diagnosis, and management will be discussed.

Newton's gift how Sir Isaac Newton unlocked the system of the world

CERN Document Server

Berlinski, David

2000-01-01

Sir Isaac Newton, creator of the first and perhaps most important scientific theory, is a giant of the scientific era. Despite this, he has remained inaccessible to most modern readers, indisputably great but undeniably remote. In this witty, engaging, and often moving examination of Newton's life, David Berlinski recovers the man behind the mathematical breakthroughs. The story carries the reader from Newton's unremarkable childhood to his awkward undergraduate days at Cambridge through the astonishing year in which, working alone, he laid the foundation for his system of the world, his Principia Mathematica, and to the subsequent monumental feuds that poisoned his soul and wearied his supporters. An edifying appreciation of Newton's greatest accomplishment, Newton's Gift is also a touching celebration of a transcendent man.

The creativity of Crumb: research on the effects of psychedelic drugs on the comic art of Robert Crumb.

Science.gov (United States)

Jones, Matthew T

2007-09-01

This article investigates the influence of perception that is altered by psychedelic drugs on processes of creativity through a case study of the work of well-known comic artist Robert Crumb. Samples of Crumb's work before, during, and after the period of his use of psychedelic drugs are content analyzed and compared according to the categorization offered by Janiger and Dobkin de Rios (1989). The results of the comparison indicate that Robert Crumb's drug use significantly altered the stylistic approach of his artwork not only during the period of his drug use, but long after he had stopped using drugs.

Dynamics analysis of SIR epidemic model with correlation coefficients and clustering coefficient in networks.

Science.gov (United States)

Zhang, Juping; Yang, Chan; Jin, Zhen; Li, Jia

2018-07-14

In this paper, the correlation coefficients between nodes in states are used as dynamic variables, and we construct SIR epidemic dynamic models with correlation coefficients by using the pair approximation method in static networks and dynamic networks, respectively. Considering the clustering coefficient of the network, we analytically investigate the existence and the local asymptotic stability of each equilibrium of these models and derive threshold values for the prevalence of diseases. Additionally, we obtain two equivalent epidemic thresholds in dynamic networks, which are compared with the results of the mean field equations. Copyright © 2018 Elsevier Ltd. All rights reserved.

Optimizing Real-Time Vaccine Allocation in a Stochastic SIR Model.

Directory of Open Access Journals (Sweden)

Chantal Nguyen

Full Text Available Real-time vaccination following an outbreak can effectively mitigate the damage caused by an infectious disease. However, in many cases, available resources are insufficient to vaccinate the entire at-risk population, logistics result in delayed vaccine deployment, and the interaction between members of different cities facilitates a wide spatial spread of infection. Limited vaccine, time delays, and interaction (or coupling of cities lead to tradeoffs that impact the overall magnitude of the epidemic. These tradeoffs mandate investigation of optimal strategies that minimize the severity of the epidemic by prioritizing allocation of vaccine to specific subpopulations. We use an SIR model to describe the disease dynamics of an epidemic which breaks out in one city and spreads to another. We solve a master equation to determine the resulting probability distribution of the final epidemic size. We then identify tradeoffs between vaccine, time delay, and coupling, and we determine the optimal vaccination protocols resulting from these tradeoffs.

Robert Kramer: técnica, paixão e ideologia

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Jorge La Ferla

2011-01-01

Full Text Available Uma revisão crítica da obra do cineasta Robert Kramer, considerando as relações que propõe sua obra, a partir da utilização virtuosa de diversas máquinas audiovisuais em suas especificidades e combinações. O cinema, o vídeo, a televisão e as novas tecnologias constituem, em Kramer, processos de criação que dão origem a um trabalho expressivo com os dispositivos fotoquímicos, eletrônicos e digitais.

Who's who on the Board

International Nuclear Information System (INIS)

Anon.

1988-01-01

Brief summaries of the curriculum vitae and present positions held by each member of the National Radiological Protection Board are given. The members are Sir Richard Southwood, Mr. A.M. Allen, Professor A. Barret, Professor J.H. Edwards, Professor H.J. Evans, Professor K.J. Evans, Professor P. Haggett, Professor J.R. Lee, Professor J.S. Orr, Dr. R. Owen, Professor J. Peto, Dr. D.H. Roberts and Mr. M.E. Trowbridge. (U.K.)

[Margaret Cavendish vs Robert Hooke: An impossible duel].

Science.gov (United States)

Aït-Touati, Frédérique

2016-12-01

In 1665, Robert Hooke published his major work in microscopy, Micrographia, a defense of experimental philosophy. The following year, Margaret Cavendish, Duchess of Newcastle, published at her own expense a treatise and a novel that undermined the basis of this new science. The dispute broke out at the initiative of the Duchess, in the context of a vast controversy about the legitimacy and the efficiency of optical instruments in natural philosophy. All the figures of the dual are used, except one: the counterattack. Cavendish, indeed, was alone on the battlefield. Is it possible to call a dual a battle with only one combatant? This particular case of dispute that stops owing to the shortage of combatants is the subject of this article.

USA mõtleja : vaid rikkus riiki koos ei hoia / Robert Putnam ; interv. Erkki Bahovski

Index Scriptorium Estoniae

Putnam, Robert

2006-01-01

USA Harvardi ülikooli politoloogiaprofessori Robert Putnami arvates on etniliselt mitmekesistes riikides ühtsustunde loomine raske, selle saavutamisele aitaksid kaasa ühiskonna pingevabam enesemääratlus ning paindlikumad töögraafikud naistele ühendamaks pere tööga. Lisa: Üksi või koos?

Empirical Asset Pricing: Eugene Fama, Lars Peter Hansen, and Robert Shiller

OpenAIRE

Campbell, John Y.

2016-01-01

The Nobel Memorial Prize in Economic Sciences for 2013 was awarded to Eugene Fama, Lars Peter Hansen, and Robert Shiller for their contributions to the empirical study of asset pricing. Some observers have found it hard to understand the common elements of the laureates research, preferring to highlight areas of disagreement among them. This paper argues that empirical asset pricing is a coherent enterprise, which owes much to the laureates seminal contributions, and that important themes in ...

Kolm vaadet Tallinna vanalinnale / Villem Tomiste, Martin Aunin, Robert Treufeldt ; intervjueerinud Ingrid Ruudi

Index Scriptorium Estoniae

Tomiste, Villem, 1975-

2009-01-01

Tallinna vanalinna ja kesklinna piiril asuv kvartal 57B, mis piirneb Aia, Vana-Viru, Inseneri tänava ja Mere Puiesteega, ajendas vanalinna hoonestuspõhimõtete ja tulevikulahenduste üle arutama arhitekte Villem Tomistet, Martin Auninit ning arhitektuuriajaloolast, ICOMOSi Eesti komitee esimeest Robert Treufeldti. Pikemalt korterelamust Aia 4/Vana-Viru 13, Aia 6 ja 8 detailplaneeringu eskiisist

More Misbehavior of Organisms: A Psi Chi Lecture by Marian and Robert Bailey

Science.gov (United States)

Bihm, Elson M.; Gillaspy, J. Arthur, Jr.; Abbott, Hannah J.; Lammers, William J.

2010-01-01

In 1992, Dr. Marian Breland Bailey, assisted by her husband Robert E. Bailey, gave the following presentation at the Psi Chi Banquet of the University of Central Arkansas. She and her first husband, Keller Breland, were students of B. F. Skinner and established Animal Behavior Enterprises (ABE) in 1947 and the IQ Zoo in 1955. Unknown to many…

Robert Aymar awarded Global Energy prize

CERN Multimedia

2006-01-01

CERN Director-General Robert Aymar was recently named one of three laureates of the 2006 Global Energy International Prize for 'the development of scientific and engineering foundation for the ITER project.' ITER is an experiment planned to be built in Europe at Cadarache (South of France) and designed to show the scientific and technological feasibility of a full-scale fusion power reactor. The other two laureates, who worked with Aymar on the project, are former President of the ITER Council, Russian Academician Evgeny Velikhov, and Japan's Dr Masaji Yoshikawa, ITER's former Vice President. Aymar headed ITER from 1994 to 2003. 'This prize is not only a great honour for me and my friends and colleagues of many years at ITER, Evgeny Velikhov and Masaji Yoshikawa,' Aymar said. 'It is above all a recognition of the effort of all those who have been involved with the ITER project and worked over the years to ensure the first step in proving that fusion will provide a new sustainable energy source for the plane...

The development of a wetland classification and risk assessment index (WCRAI) for non-wetland specialists for the management of natural freshwater wetland ecosystems

CSIR Research Space (South Africa)

Oberholster, Paul J

2014-02-01

Full Text Available Botany 55, 247-260. Mitchell, P., 1990. The Enviromental Conditions of Victoria Streams, Department of Water Resources, Melbourne, Victoria. Mitsch, W.J., Gosselink, J.G., 2000. Wetlands 3 third edition, John Wiley& Sons Inc, New York. Morant, P.D., 1983...

Shuttle imaging radar-A (SIR-A) data analysis. [geology of the Ozark Plateau of southern Missouri, land use in western Illinois, and vegetation types at Koonamore Station, Australia

Science.gov (United States)

Arvidson, R. E.

1983-01-01

The utility of shuttle imaging radar (SIR-A) data was evaluated in several geological and environmental contexts. For the Ozark Plateau of southern Missouri, SIR-A data were of little use in mapping structural features, because of generally uniform returns. For western Illinois, little was to be gained in terms of identifying land use categories by examining differences between overlapping passes. For southern Australia (Koonamore Station), information ion vegetation types that was not obtainable from LANDSAT MSS data alone was obtained. Specifically, high SIR-A returns in the Australian site were found to correlate with locations where shrubs increase surface roughness appreciably. The Australian study site results demonstrate the synergy of acquiring spectral reflectance and radar data over the same location and time. Such data are especially important in that region, since grazing animals have substantially altered and are continuing to alter the distribution of shrublands, grasslands, and soil exposures. Periodic, synoptic acquisition of MSS and SAR data would be of use in monitoring the dynamics of land-cover change in this environment.

Sir William Turner (1832-1916) - Lancastrian, anatomist and champion of the Victorian era.

Science.gov (United States)

Wessels, Quenton; Correia, Janine Carla; Taylor, Adam M

2016-11-01

Sir William Turner, a Lancastrian, was renowned as a scientist, anatomist and a great reformer of medical education. His students became anatomists at various international institutions, which consequently shaped the future of anatomy as a subject matter both in the United Kingdom and in South Africa. Although Turner's accomplishments have been documented, little is known about the details that determined his career path and the individuals that shaped his future. Here the authors aim to highlight some aspects of Turner's academic achievements and his personal life as well as how he crossed paths with other great minds of the Victorian era including Richard Owen, Charles Darwin, James Paget and Joseph Lister. © The Author(s) 2015.

Performance comparison and selection criteria: an assessment for choosing the best flight detector for the SIR-2 NIR-spectrometer on Chandrayaan-1

Science.gov (United States)

Sitek, P.; Vilenius, E.; Mall, U.

2008-01-01

We describe the performance evaluation of a sample of InGaAs detectors from which the best unit had to be selected for the flight model of the SIR-2 NIR-spectrometer to be flown on the Chandrayaan-1 mission in 2008.

Sir John Adams: his legacy to the world of particle accelerators

CERN Document Server

Wilson, E J N

2011-01-01

John Adams acquired an unrivalled reputation for his leading part in designing and constructing the Proton Synchrotron (PS) in CERN’s early days. In 1968, and after several years heading a fusion laboratory in the UK, he came back to Geneva to pilot the Super Proton Synchrotron (SPS) project to approval and then to direct its construction. By the time of his early death in 1984 he had built the two flagship proton accelerators at CERN and, during the second of his terms as Director-General, he laid the groundwork for the proton–antiproton collider which led to the discovery of the intermediate vector boson. How did someone without any formal academic qualification achieve this? What was the magic behind his leadership? The speaker, who worked many years alongside him, will discuss these questions and speculate on how Sir John Adams might have viewed today’s CERN.

Teorizando o mundo contemporâneo: Robert Brenner; Giovanni Arrighi; David Harvey

Directory of Open Access Journals (Sweden)

Moishe Postone

2008-07-01

Full Text Available O artigo busca apreender as profundas transformações sociais, políticas, econômicas e culturais que marcaram as três últimas décadas, em contraste com o período de prosperidade subseqüente à Segunda Guerra Mundial. Para tanto, o autor analisa criticamente três obras específicas que abordam o período: "The economics of global turbulence", de Robert Brenner, O longo século XX, de Giovanni Arrighi, e A condição pós-moderna, de David Harvey. O procedimento metateórico adotado permite apontar os requisitos de uma teoria crítica adequada ao capitalismo contemporâneo.The article aims to apprehend the deep social, political, economic and cultural transformations that characterized the three last decades, in contrast with the prosperity period following the Second World War. Therefore, the author critically analyses three specific works that deal with that period: "The economics of global turbulence", by Robert Brenner, The long Twentieth Century, by Giovanni Arrighi, and The conditions of postmodernity, by David Haravey. The metatheoric procedure adopted allows him to indicate the requisites of an adequate critical theory of contemporary capitalism.

Robert Bartini and His Contribution to the Development of Transport and Aviation

Science.gov (United States)

Težak, Sergej

2017-10-01

After the First World War, the young Soviet Union (USSR) desperately needed new engineers and scientists who would provide the new country with development of modern industry and transportation. At that time, Western European countries had knowledge and experience, especially in the field of aviation. One of the young engineers was Robert Bartini, who was educated in Austria-Hungary and Italy, and graduated from Milan Polytechnic Institute. In 1923, he fled Italy to escape Fascists and emigrated in Soviet Union. This article is a brief description of aircraft designer Robert Bartini and his role in the development of the military, passenger and transport aviation. In addition, it presents his vision of the intercontinental and continental high-speed transport, which was his focus in the last years of his work and creation. He worked as a researcher and expert in the former Soviet Union, therefore, more detailed and relevant information on his work has been revealed to the public in recent years. In Russia, he is very popular as a researcher and developer. There are many books about him in Russian and Italian language, but not in English. Thus, his work is still quite unknown in the West. He was born in Kanjiza (today Serbia) in 1897, and spent his youth in Fiume (Rijeka, today Croatia).

Low sensitivity of qSOFA, SIRS criteria and sepsis definition to identify infected patients at risk of complication in the prehospital setting and at the emergency department triage.

Science.gov (United States)

Tusgul, Selin; Carron, Pierre-Nicolas; Yersin, Bertrand; Calandra, Thierry; Dami, Fabrice

2017-11-03

Sepsis is defined as life-threatening organ dysfunction caused by a host response to infection. The quick SOFA (qSOFA) score has been recently proposed as a new bedside clinical score to identify patients with suspected infection at risk of complication (intensive care unit (ICU) admission, in-hospital mortality). The aim of this study was to measure the sensitivity of the qSOFA score, SIRS criteria and sepsis definitions to identify the most serious sepsis cases in the prehospital setting and at the emergency department (ED) triage. We performed a retrospective study of all patients transported by emergency medical services (EMS) to the Lausanne University Hospital (CHUV) over twelve months. All patients with a suspected or proven infection after the ED workup were included. We retrospectively analysed the sensitivity of the qSOFA score (≥2 criteria), SIRS criteria (≥2 clinical criteria) and sepsis definition (SIRS criteria + one sign of organ dysfunction or hypoperfusion) in the pre-hospital setting and at the ED triage as predictors of ICU admission, ICU stay of ≥3 days and early (i.e. 48 h) mortality. No direct comparison between the three tools was attempted. Among 11,411 patients transported to the University hospital, 886 (7.8%) were included. In the pre-hospital setting, the sensitivity of qSOFA reached 36.3% for ICU admission, 17.4% for ICU stay of three days or more and 68.0% for 48 h mortality. The sensitivity of SIRS criteria reached 68.8% for ICU admission, 74.6% for ICU stay of three days or more and 64.0% for 48 h mortality. The sensitivity of sepsis definition did not reach 60% for any outcome. At ED triage, the sensitivity of qSOFA reached 31.2% for ICU admission, 30.5% for ICU stay of ≥3 days and 60.0% for mortality at 48 h. The sensitivity of SIRS criteria reached 58.8% for ICU admission, 57.6% for ICU stay of ≥3 days 80.0% for mortality at 48 h. The sensitivity of sepsis definition reached 60.0% for 48 h mortality. Incidence

A class of stochastic delayed SIR epidemic models with generalized nonlinear incidence rate and temporary immunity

Science.gov (United States)

Fan, Kuangang; Zhang, Yan; Gao, Shujing; Wei, Xiang

2017-09-01

A class of SIR epidemic model with generalized nonlinear incidence rate is presented in this paper. Temporary immunity and stochastic perturbation are also considered. The existence and uniqueness of the global positive solution is achieved. Sufficient conditions guaranteeing the extinction and persistence of the epidemic disease are established. Moreover, the threshold behavior is discussed, and the threshold value R0 is obtained. We show that if R0 extinct with probability one, whereas if R0 > 1, then the system remains permanent in the mean.

Florence Nightingale (1820-1910) and Sir John Forbes (1787-1861): neighbours in Old Burlington Street, Westminster.

Science.gov (United States)

Agnew, Robin

2015-05-01

The year 2010 marks the centenary of the birth of Florence Nightingale and will, no doubt, be universally remembered. Her life and nursing career have recently been fully described by Bostridge. It is less well known that her neighbour from November 1856 was the distinguished Scottish physician Sir John Forbes MD Edin FRCP Lond FRS DCL Oxon. Although they never met, they exchanged copies of each other's books and shared a mutual respect. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Los orígenes del grial en la literatura medieval: de Chrétien de Troyes a Robert de Boron

Directory of Open Access Journals (Sweden)

Mario Martín Botero

2010-12-01

Full Text Available Este artículo muestra el origen literario del tema del Grial en la literatura medieval francesa, abordando dos textos esenciales para el surgimiento y consolidación de la “literatura del Grial”: Le Conte du Graal de Chrétien de Troyes y Le Roman de l’Estoire dou Graal de Robert de Boron. Los autores de estas obras establecen las bases para el desarrollo de toda una temática que gira alrededor del Grial a partir del siglo XII hasta nuestros días. El artículo muestra cómo de un objeto apenas sagrado en el texto de Chrétien de Troyes se pasa a una reliquia de la sangre de Cristo en la versión de Robert de Boron.This paper studies the literary origin of the Grail legend in medieval French literature, taking into account two important romances: Le Conte du Graal by Chrétien de Troyes and Le Roman de l’Estoire dou Graal by Robert de Boron. In these two texts the authors established the basis for the development of a new subject matter around the mysterious object called “Grail” from the Middle Ages to the present times. It will also be shown how an object, not totally sacred in Chrétien de Troyes, becomes a relic related with Jesus’s blood in Robert de Boron.

The Impossibility of Maintaining the Minimal State of Robert Nozick

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Virgílio Queiroz de Paula

2015-12-01

Full Text Available In this paper we analyze how Robert Nozicks minimal state proposed would invariably end, unless its members were coerced by the central government to contribute to its maintenance. And, in this case, rights and freedom protected under the philosophers state would obviously be violated. We also analyze the flaws in Nozicks model through economic bias in order to show - through game theory and logic of collective action  how an organization that provides nonexclusive public goods is vulnerable to the action of free-riders, thus increasing the costs of its performance, and decreasing motivation for its existence.

Taasavatud mälestuskivi väärtustab Robert von Tolli tegemisi / Külli Kriis

Index Scriptorium Estoniae

Kriis, Külli, 1961-

2007-01-01

26. juulil taasavati Kukruse külas mälestuskivi, mille Kukruse mõisa omanik Robert von Toll sinna aastal 1866 pargi rajamise puhul püstitas. Ilmunud ka: Severnoje Poberezhje, 28. juuli 2007 (Vnov ustanovlennõi kamen - dan pamjati dejatelnosti Roberta fon Tollja)

Robert Williams Wood: pioneer of invisible light.

Science.gov (United States)

Sharma, Shruti; Sharma, Amit

2016-03-01

The Wood's lamp aids in the diagnosis of multiple infectious, inflammatory and neoplastic dermatologic conditions. Although the Wood's lamp has many applications, which have improved both the diagnosis and management of disease, the man credited for its invention is relatively unknown in medicine. Robert Williams Wood, a prominent physicist of the early 20th century, is credited for the invention of the Wood's lamp. Wood was the father of infrared and ultraviolet photography and made significant contributions to other areas in optics and spectroscopy. Wood's work encompassed the formative years of American Physics; he published over 200 original papers over his lifetime. A few years after the invention of the Wood's lamp for ultraviolet photography, physicians in Europe adopted the Wood's lamp for dermatologic applications. Wood's lamp remains popular in clinics globally, given its ease of use and ability to improve diagnostic precision. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Sir Harold Delf Gillies, the otolaryngologist and father of modern facial plastic surgery: review of his rhinoplasty case notes.

Science.gov (United States)

Spencer, C R

2015-06-01

Sir Harold Gillies, born in New Zealand, is widely considered a British icon and the father of modern plastic surgery. This article provides an overview of his life and the circumstances which led to him laying the foundations of plastic surgery in Britain in the early twentieth century. A hand search and review of case notes from the Gillies Archives at Queen Mary's Hospital in Sidcup, UK, where he made history, was conducted. Gillies' ongoing legacy was found to also include his influence on the development of his cousin Sir Archibald McIndoe's work. Gillies was a talented sportsman who engaged in charitable activities. Additionally, he was a gifted teacher, with his hospital attracting many young surgeons from around the world. He was found to have expressed genius in both the design and execution of the art and science of surgery. He incepted reconstructive techniques ranging from the world's first gender reassignment operation to facial reanimation procedures for the treatment of facial paralysis. His operative work on ex-servicemen in need of complex rhinoplasty and in particular the inception of the tubed pedicle flap are depicted.

Reproduction of the San Joaquin kit fox (Vulpes velox macrotis) on Camp Roberts Army National Guard Training Site, California

International Nuclear Information System (INIS)

Spencer, K.A.; Berry, W.H.; Standley, W.G.; O'Farrell, T.P.

1992-09-01

The reproduction of a San Joaquin kit fox population (Vulpes velox macrotis) was investigated at Camp Roberts Army National Guard Training Site, California, from November 1988 through September 1991. Of 38 vixens radiocollared prior to parturition, 12 (32%) were successful in raising pups from conception to the point where pups were observed above ground. No yearling vixens were known tb be reproductively active. The mean litter size during 1989 - 1991 was 3.0 (n = 21, SE = 0.28) and ranged from one to six pups. Both the proportion of vixens successfully raising pups and the mean litter size observed at Camp Roberts during this study were lower than those reported at other locations. Sex ratios of kit fox pups were male biased two of the three years, but did not differ statistically from 1:1 throughout the study. Whelping was estimated to occur between February 15 and March 5. Results of this study support previous reports that kit foxes are primarily monogamous, although one case of polygamy may have occurred. Both the proportion of dispersing radiocollared juveniles (26%) and the mean dispersal distance (5.9 km) of juveniles at Camp Roberts appeared low compared to other locations

Robert Michels y las teorías elitista-competitivas de la democracia

OpenAIRE

Caparrós Valderrama, Rafael

2008-01-01

Robert Michel's main work is "Political parties. A Sociological Study on the Oligarchical Tendencies of Modern Democracy", issued in 1911, which is an analysis on the internal organization evolving dynamics of the German Social-Democrat Party (SDP), to which the author was intensely attached for several years. The aim of this essay is hte sociological study of the leadership emergence, power psicology and the organizational oligarchical tendencies. In it all argumentation can be found on the ...

O EPÍLOGO DA TEORIA DOS DIREITOS FUNDAMENTAIS EM ROBERT ALEXY

OpenAIRE

Araújo Silveira, Whenry Hawlysson; Bruno da Silva, Alexandre Antônio

2014-01-01

Com o advento da Constituição Federal de 1988, foram implementados novos conceitos concernentes à Teoria do Direito por consequência de um fenômeno mundialmente conhecido como Neoconstitucionalismo. Uma destas mutações se dá por seu caráter axiológico e diz respeito à teoria dos direitos fundamentais. Robert Alexy inova seu pensamento a afirmar que o conflito entre direitos e garantias fundamentais deve ser resolvido pelo instituto da ponderação e afirma que esse instituto não se trata de um ...

Early Sherlockian scholarship: Non/fiction at play

Directory of Open Access Journals (Sweden)

Kate M. Donley

2017-03-01

Full Text Available Sherlockian scholarship is a display of intellect, wit, and canonical expertise that requires a cunning manipulation of a story world and of nonfiction. This playful style of writing defies easy classification in the terminology of fan and literary studies. Emerging in the early 20th century, Sherlockian scholarship had a tremendous surge in popularity in the late 1920s and early '30s in articles by renowned British and American authors, including Dorothy L. Sayers, Christopher Morley, Sir Desmond MacCarthy, Sir Sydney Castle Roberts, and Ronald A. Knox. The sustained popularity of Sherlockian scholarship owes much to these initial players, whose sparkling prose conjures a bygone era of repartee. In this study, I present a chronological survey of two early periods in Sherlockian scholarship to understand its poetics, popularity, generic identity, and contemporary relevance.

Robert Hare's Theory of Galvanism: A Study of Heat and Electricity in Early Nineteenth-Century American Chemistry.

Science.gov (United States)

Fisher, Amy

2018-04-09

As a professor of chemistry at the University of Pennsylvania, Robert Hare actively shaped early American science. He participated in a large network of scholars, including Joseph Henry, François Arago, and Jacob Berzelius, and experimented with and wrote extensively about electricity and its associated chemical and thermal phenomena. In the early nineteenth century, prominent chemists such as Berzelius and Humphry Davy proclaimed that a revolution had occurred in chemistry through electrical research. Examining Robert Hare's contributions to this discourse, this paper analyzes how Hare's study of electricity and the caloric theory of heat led him to propose a new theory of galvanism. It also examines the reception of Hare's work in America and Great Britain, highlighting the contributions of early American chemists to the development of electrochemistry.

Malingering as a Categorical or Dimensional Construct: The Latent Structure of Feigned Psychopathology as Measured by the SIRS and MMPI-2

Science.gov (United States)

Walters, Glenn D.; Rogers, Richard; Berry, David T. R.; Miller, Holly A.; Duncan, Scott A.; McCusker, Paul J.; Payne, Joshua W.; Granacher, Robert P., Jr.

2008-01-01

The 6 nonoverlapping primary scales of the Structured Interview of Reported Symptoms (SIRS) were subjected to taxometric analysis in a group of 1,211 criminal and civil examinees in order to investigate the latent structure of feigned psychopathology. Both taxometric procedures used in this study, mean above minus below a cut (MAMBAC) and maximum…

Paleodrainages of the Eastern Sahara - The radar rivers revisited (SIR-A/B implications for a mid-tertiary Trans-African drainage system)

Science.gov (United States)

Mccauley, J. F.; Breed, C. S.; Schaber, G. G.; Mchugh, W. P.; Haynes, C. C.

1986-01-01

The images obtained by the Shuttle Imaging Radar (SIR)-A and -B systems over the southwestern Egypt and northwestern Sudan were coregistered with the Landsat images and the existing maps to aid in extrapolations of the buried paleodrainages ('radar rivers'), first discovered by SIR-A. Field observations explain the radar responses of three types of radar rivers, RR-1 (broad, aggraded valleys filled with alluvium), RR-2 (braided channels inset in the RR-1 valleys), and RR-3 (narrow, long, bedrock-incised channels). A generalized model of the radar rivers, based on field studies and regional geologic relations, shows inferred changes in river regimen since the large valleys were established during the later Paleogene-early Neogene. It is suggested that a former Trans-African master stream system may have flowed from headwaters in the Red Sea Hills southwestward across North Africa, discharging into the Atlantic at the Paleo-Niger delta, prior to the Neogene domal uplifts and building of volcanic edifices across the paths of these ancient watercourses.

Discussing compliance. Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm May 3 and 4, 1999

Energy Technology Data Exchange (ETDEWEB)

Jensen, Mikael

1999-06-01

Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm. The report also contains bibliographical information and preliminary observations made by Robert Bernero and Chris Whipple.

Discussing compliance. Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm May 3 and 4, 1999

International Nuclear Information System (INIS)

Jensen, Mikael

1999-06-01

Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm. The report also contains bibliographical information and preliminary observations made by Robert Bernero and Chris Whipple

Occupational exposure following Yttrium-90 microspheres SIR therapy

International Nuclear Information System (INIS)

Fontaine, P.; Boirie, G.; Dieudonne, A.; Leguludec, D.; Lebtahi, R.; Ben Reguiga, M.

2015-01-01

Full text of publication follows. Introduction: Selective Internal Radiation Therapy (SIRT) is a promising technique for solid hepatic neoplasms treatment. SIRT consists in implanting radioactive microspheres (RMS) in targeted hepatic lesions via femoral artery. Two RMS-Therapsheres [glass-microspheres/TSR] and Sir-Spheres [resin-spheres/SSR]- are marketed in the European market, both radiolabeled with Yttrium-90. The objective of this study is to assess occupational exposure for nuclear medicine, radiology and clinical staff involved in Y 90 -RMS preparation and implantation. Materials and methods: The study was conducted on 20 patients treated for Hepato-Cellular Carcinoma: 10 treated with TSR and 10 with SSR. Dose rate (DR, mSv/h) or absorbed doses (mSv) measurements were made during all steps of TSR and SSR handling: sources receipt and unpacking, preparation, transport to radiology, implantation, and patient care. Measurements were made with portable ionization chamber(Babyline/Nardeux), spectrometer(FieldSpect/Aries), digital dosimeter (NED/Unfors) and operational dosimeter (Mk2/Siemens). Values were expressed as mean±SD. Results: patients received of 1.8 GBq to 3.1 GBq of TSR and 0.55 GBq to 2.4 GBq of SSR. TSR were delivered ready-to-use with the prescribed activity. For SSR only one activity was commercially available and shipped (3 GBq at calibration-time)requiring a preparation step to adjust needed activity. DR measured during RMS was 1723 ± 157 μSv/h SSR and 1189 ± 92 μSv/h for TSR. When preparing spheres in radiopharmacy, fingers and whole body doses were respectively 8326 ± 2360 μSv and 12.3 ± 5,2 μSv for Sir-Spheres vs. 33.5 ± 7.8 μSv and 1.1 ± 0.3 μSv for TSR. DR in contact with carrying case during RMS transfer to radiology were 299 ± 102 μSv/h for SSR and 5.3 ± 1.2 μSv/h for TSR. During RMS infusion, radiologist's finger doses were limited to 3.6 ± 1 μSv for SSR and 0.7± 0.3 μSv for TSR. Finally, following RMS

CBO Testimony: Statement of Robert F. Hale, Assistant Director, National Security Division, Congressional Budget Office

National Research Council Canada - National Science Library

Hale, Robert F

1991-01-01

.... This testimony, by Robert F. Hale, Congressional Budget Office, covers the following topics: Socioeconomic Backgrounds of Enlisted Recruits, Racial Mix of Enlisted Recruits, Shifts in Recruiting during the 1980s, Altering the Composition of the Military: Reserve Mobilization and Conscription, and Should the Social Composition of the Military be a Concern?

Activatable Optical Imaging with a Silica-Rhodamine Based Near Infrared (SiR700) Fluorophore: A comparison with cyanine based dyes

Science.gov (United States)

McCann, Thomas E.; Kosaka, Nobuyuki; Koide, Yuichiro; Mitsunaga, Makoto; Choyke, Peter L.; Nagano, Tetsuo; Urano, Yasuteru; Kobayashi, Hisataka

2011-01-01

Optical imaging is emerging as an important tool to visualize tumors. However, there are many potential choices among the available fluorophores. Optical imaging probes that emit in the visible range can image superficial tumors with high quantum yields, however, if deeper imaging is needed then near infrared (NIR) fluorophores are necessary. Most commercially available NIR fluorophores are cyanine based and are prone to non-specific binding and relatively limited photostability. Silica-containing rhodamine (SiR) fluorophores represent a new class of NIR fluorophores, which permit photoactivation via H-dimer formation as well as demonstrate improved photostability. This permits higher tumor-to-background ratios (TBRs) to be achieved over longer periods of time. Here, we compared an avidin conjugated with SiR700 (Av-SiR700) to similar compounds based on cyanine dyes (Av-Cy5.5 and Av-Alexa Fluor 680) in a mouse tumor model of ovarian cancer metastasis. We found that the Av-SiR700 probe demonstrated superior quenching enabling activation after binding-internalization to the target cell. As a result, Av-SiR700 had higher TBRs compared to Av-Cy5.5, and better biostability compared to Av-Alexa Fluor 680. PMID:22034863

Threshold dynamics and ergodicity of an SIRS epidemic model with Markovian switching

Science.gov (United States)

Li, Dan; Liu, Shengqiang; Cui, Jing'an

2017-12-01

This paper studies the spread dynamics of a stochastic SIRS epidemic model with nonlinear incidence and varying population size, which is formulated as a piecewise deterministic Markov process. A threshold dynamic determined by the basic reproduction number R0 is established: the disease can be eradicated almost surely if R0 disease persists almost surely if R0 > 1. The existing method for analyzing ergodic behavior of population systems has been generalized. The modified method weakens the required conditions and has no limitations for both the number of environmental regimes and the dimension of the considered system. When R0 > 1, the existence of a stationary probability measure is obtained. Furthermore, with the modified method, the global attractivity of the Ω-limit set of the system and the convergence in total variation to the stationary measure are both demonstrated under a mild extra condition.

Science, Beliefs and Knowledge: A Personal Reflection on Robert J. Aumann’s Approach

OpenAIRE

Gil Kalai

2006-01-01

On the occasion of Robert J. Aumann's being awarded the 2005 Nobel Prize in Economics, this paper gives a personal view on some of Aumann's contributions, and primarily on his approach to foundational issues in game theory, economics, and science as a whole. It is based on numerous discussions and e-mail exchanges we had in the 1990's, dealing with various scientific and political matters, including our long debate on the ``Bible Code'' controversy.

Modification of Roberts' Theory for Rocket Exhaust Plumes Eroding Lunar Soil

Science.gov (United States)

Metzger, Philip T.; Lane, John E.; Immer, Christopher D.

2008-01-01

Roberts' model of lunar soil erosion beneath a landing rocket has been updated in several ways to predict the effects of future lunar landings. The model predicts, among other things, the number of divots that would result on surrounding hardware due to the impact of high velocity particulates, the amount and depth of surface material removed, the volume of ejected soil, its velocity, and the distance the particles travel on the Moon. The results are compared against measured results from the Apollo program and predictions are made for mitigating the spray around a future lunar outpost.

Robert Molesworth's An Account of Denmark as it was in 1692

DEFF Research Database (Denmark)

Olden-Jørgensen, Sebastian

2008-01-01

Robert Moleswort's An Account of Denmark as it was in 1692 is a violent political pamphlet in the early British Whig-tradition aimed at underscoring republican values by pointing to the dreadful example of Danish Absolutist slavery. It was a bestseller on an international scale. In his book...... of these was Ludvig Holberg's Description of Denmark and Norway (1729) which counters Molesworth on the basis of history and natural law - and in a witty style. Thus the republican manifesto of Molesworth became instrumental in shaping the political outlook and language of the very moderate, loyal and anything...

Justice, Integrity and Fairness: Relevant Questions About Robert Nozick Political Theory

Directory of Open Access Journals (Sweden)

Carlos Fernando Cruz da Silva

2016-11-01

Full Text Available The present work develops and analysis about Robert Nozick political theory based in thesis defended by Ronald Dworkin. The central objective of this paper is to investigate the validity or the invalidity of the justice principles proposed by Nozick under the integrity theory. The methodology utilized to construct the definitive hypothesis was based, initially, in a theoretical search, developed through of an bibliographical lifting of the principal involved authors texts. After the survey, a descriptive analysis of the texts was executed and, then, was executed and critical analysis. At the end, an definitive proposal was constructed with an deductive reasoning.

The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from Narcissus 'Sir Winston Churchill'

NARCIS (Netherlands)

Ingkaninan, K.; Hazekamp, A.; de Best, C.M.; Irth, H.; Tjaden, U.R.; van der Heijden, R.; van der Greef, J.; Verpoorte, R.

2000-01-01

An HPLC with on-line coupled UV/MS-biochemical detection method for acetylcholinesterase (AChE) inhibitors in natural sources has been developed. The potential of this method is shown by the isolation of a new AChE inhibitor from the alcoholic extract of Narcissus 'Sir Winston Churchill'. Combining

Contemporary Hegelian Scholarship: Robert Stern’s Holistic Reading of Hegel

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Paniel Reyes Cardenas

2015-12-01

Full Text Available This is a monographic presentation in which the author depicts the guidelines of Professor Robert Stern’s interpretation of Hegelian Metaphysics by emphasizing in its characteristic holistic reading. The proposal is that some key fundamental topics of Hegelian scholarship will emerge with a clarified understanding after this reading: the concept of Truth and absolute knowledge are reassessed by showing the necessary connection of Epistemology and Metaphysics in Hegel. Hegelian Metaphysics, accordingly, appears ultimately as the principle for a reading of Hegel’s entire philosophy and illuminates its nature of general metaphysical inquiry. Finally, this reading allows drawing on the connection of Hegel’s Idealism with the Pragmatist tradition initiated by Peirce.

Sir Sayyid Ahmed Kahn's History of the Bijnor Rebellion, Translated with Notes and Introduction. South Asia Series, Occasional Paper No. 17.

Science.gov (United States)

Michigan State Univ., East Lansing. Asian Studies Center.

The Bijnor Rebellion of 1857 was a revolt of the Muslim minority in the Bijnor district of India against the British East India Company and Hindu loyalists. Sir Sayyid Ahmad Khan was an Indian Muslim serving the British Company. His account of the events of 1857 is the only one produced by an Indian who both participated in and analyzed the…

Sir Karl Popper (1902-1994): in memoriam, 15 years later.

Science.gov (United States)

Notturno, Mark Amadeus

2009-12-01

September 17th, 2009 marks the 15th anniversary of Sir Karl Popper's death. Popper was an outspoken champion of critical rationalism, and a constant critic of authoritarian tendencies in science and society. He was also one of the spiritual founders of this journal and served on its first editorial advisory board. Popper was recognized around the world as one of the 20th century's greatest philosophers of science and one of its most articulate and influential critics of Marxism and closed society. When he died, the contemporary wisdom among professional philosophers was that his philosophy was generally right-but somehow obsolete. Some commentators said that it was now obvious that scientific theories cannot be shown to be true. Others said that we had witnessed the end of history and that his critique of closed societies, while no doubt important in its day, had been fully assimilated into Western thinking and still had meaning, if at all, only for the democracies in transition that were trying to emerge from the former Soviet Union. But 15 years after his death, a look at science and society around the world gives us good reason to remember his philosophy.

Reconnaissance geologic mapping of a portion of the rain‐forest‐covered Guiana Shield, Northwestern Brazil, using SIR-B and digital aeromagnetic data

Science.gov (United States)

Pellon de Miranda, Fernando; McCafferty, Anne E.; Taranik, James V.

1994-01-01

This paper documents the result of an integrated analysis of spaceborne radar (SIR-B) and digital aeromagnetic data carried out in the heavily forested Guiana Shield. The objective of the research is to interpret the geophysical data base to its limit to produce a reconnaissance geologic map as an aid to ground work planning in a worst‐case setting. Linear geomorphic features were identified based on the interpretation of the SIR-B image. Digital manipulation of aeromagnetic data allowed the development of a color‐shaded relief map of reduced‐to‐pole magnetic anomalies, a terrace‐magnetization map, and a map showing the location of maximum values of the horizontal component of the pseudogravity gradient (magnetization boundary lines). The resultant end product was a reconnaissance geologic map where broad terrane categories were delineated and geologic faults with both topographic and magnetic expression were defined. The availability of global spaceborne radar coverage in the 1990s and the large number of existing digital aeromagnetic surveys in northwestern Brazil indicate that this approach can be potentially useful for reconnaissance geologic mapping elsewhere in the Guiana Shield.

Fermilab's Helen Edwards receives prestigious 2003 Robert R. Wilson prize from the American Physical Society

CERN Multimedia

2002-01-01

Helen Edwards has been awarded the 2003 Robert R. Wilson prize. She was cited for "her pivotal achievement and critical contribution as the leader in the design, construction, commissioning and operation of the Tevatron, and for her continued contributions to the development of high gradient superconducting linear accelerators as well as bright and intense electron sources." (1/2 page).

Business ethics and virtue: on Robert C. Solomon's many ways of being ethical.

OpenAIRE

Gallego Salvador, Francisco

2013-01-01

The present Thesis explores the possibility of applying a virtue ethics framework, based upon the Aristotelian tradition, into business ethics. The purpose of the Thesis is twofold: to give an overview of virtue ethics through Richard Taylor’s portrait and to offer a specific account of virtue ethics focused on the business realm. The examination of this virtue ethics proposal is largely founded on Robert C. Solomon’s works, which constitute the cornerstone of this Thesis. However, the critic...

Sir John Adams - His Legacy to the World of Particle Accelerators

CERN Multimedia

CERN. Geneva

2009-01-01

John Adams acquired an unrivalled reputation for his leading part in designing and constructing the PS in CERN’s early days. In 1968, and after several years heading a fusion laboratory in the UK, he came back to Geneva to pilot the SPS project to approval and then to direct its construction. At the time of his untimely death in 1984 he had built Europe’s two largest proton accelerators at CERN. He went on, during the second of his terms as DG, to lay the groundwork for the proton-antiproton collider which led to the discovery of the intermediate vector boson. How did someone without any formal academic qualification achieve this? What was the magic behind his leadership? How did he achieve political success with the Member States of CERN in turning the almost hopeless quest for approval of the SPS to CERN’s advantage? How did he view his US counterpart, R. R. Wilson? The speaker, who worked many years alongside Adams, will discuss these questions and speculate on how Sir John Adams might have viewed t...

A Historical Survey of Sir Karl Popper's Contribution to Quantum Mechanics

Directory of Open Access Journals (Sweden)

William M. Shields

2012-11-01

Full Text Available Sir Karl Popper (1902-1994, though not trained as a physicist and embarrassed early in his career by a physics error pointed out by Einstein and Bohr, ultimately made substantial contributions to the interpretation of quantum mechanics. As was often the case, Popper initially formulated his position by criticizing the views of others - in this case Niels Bohr and Werner Heisenberg. Underlying Popper's criticism was his belief that, first, the Copenhagen interpretation of quantum mechanics abandoned scientific realism and second, the assertion that quantum theory was complete (an assertion rejected by Einstein among others amounted to an unfalsifiable claim. Popper insisted that the most basic predictions of quantum mechanics should continue to be tested, with an eye towards falsification rather than mere adding of decimal places to confirmatory experiments. His persistent attacks on the Copenhagen interpretation were aimed not at the uncertainty principle itself and the formalism from which it was derived, but at the acceptance by physicists of an unclear epistemology and ontology that left critical questions unanswered. Quanta 2012; 1: 1–12.

The SIR model of Zika virus disease outbreak in Brazil at year 2015

Science.gov (United States)

Aik, Lim Eng; Kiang, Lam Chee; Hong, Tan Wei; Abu, Mohd Syafarudy

2017-05-01

This research study demonstrates a numerical model intended for comprehension the spread of the year 2015 Zika virus disease utilizing the standard SIR framework. In modeling virulent disease dynamics, it is important to explore whether the illness spread could accomplish a pandemic level or it could be eradicated. Information from the year 2015 Zika virus disease event is utilized and Brazil where the event began is considered in this research study. A three dimensional nonlinear differential equation is formulated and solved numerically utilizing the Euler's method in MS excel. It is appeared from the research study that, with health intercessions of public, the viable regenerative number can be decreased making it feasible for the event to cease to exist. It is additionally indicated numerically that the pandemic can just cease to exist when there are no new infected people in the populace.

Sir William Burnett (1779-1861), professional head of the Royal Naval Medical Department and entrepreneur.

Science.gov (United States)

Penn, Christopher

2004-08-01

Sir William Burnett (1779-1861) had an active career as a Royal Navy surgeon in the French Revolutionary and Napoleonic Wars, including service at the battles of St Vincent, the Nile and Trafalgar. From 1822 to 1855 he was professional head of the Royal Naval Medical Department, when he provided effective leadership in a time of great change. Although his official work earned him the reputation of a "hard-working, unimaginative, somewhat harsh man", his correspondence shows a very humane centre under the official carapace. His official performance and reputation were both eroded towards the end of his career by his determined promotion of zinc chloride, for which he held lucrative patents.

Dynamics of a stochastic delayed SIR epidemic model with vaccination and double diseases driven by Lévy jumps

Science.gov (United States)

Liu, Qun; Jiang, Daqing; Shi, Ningzhong; Hayat, Tasawar

2018-02-01

In this paper, we study the dynamics of a stochastic delayed SIR epidemic model with vaccination and double diseases which make the research more complex. The environment variability in this paper is characterized by white noise and Lévy noise. We establish sufficient conditions for extinction and persistence in the mean of the two epidemic diseases. It is shown that: (i) time delay and Lévy noise have important effects on the persistence and extinction of epidemic diseases; (ii) two diseases can coexist under certain conditions.

A gift of prophecy essays in celebration of the life of Robert Eugene Marshak

CERN Document Server

1994-01-01

Robert Eugene Marshak (1916-92) devoted much of his life to helping other people carry out scientific research and gather to discuss their work. In addition to his scientific statesmanship, he was an extraordinarily gifted research scientist, and many of his scientific contributions have been prophetic. This book pays homage to his creativity and continuing work, with contributions from many of the people whose lives have been influenced by him.

El Mediterráneo a través de la ficción: el extraño caso de Sir John Mandeville

Directory of Open Access Journals (Sweden)

Morales Osorio, Susana

2006-06-01

Full Text Available

The Travels of Sir John Mandeville presents the ficticious construction of the Orient through a travels tale which is primarily shaped as a pilgrimage to Jerusalem. Over and above the critical controversy about the existence of Sir John Mandeville, this book depicts in a very accurate way several key topics in the literature of the Middle Ages as it is the conception of the travel through the medieval peregrination, the homo viator as a consequence of the religious becoming which steamed the Middle Ages, or the Bible as the geography of the known world and the destination of the medieval curiosity. On the other hand, the tale shows a very special devising of the Other, of the unknown, by means of a mythical perspective, that is, through the recreation of fascinating mirabilia collection that still impress the current reader.