Validation of the Spanish SIRS with monolingual Hispanic outpatients.

Science.gov (United States)

Correa, Amor A; Rogers, Richard; Hoersting, Raquel

2010-09-01

Psychologists are faced with formidable challenges in making their assessment methods relevant to growing numbers of Hispanic clients for whom English is not the primary or preferred language. Among other clinical issues, the determination of malingering has profound consequences for clients. In this investigation, we evaluated a Spanish translation of the Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1992) with 80 Spanish-speaking Hispanic American outpatients. Using a between-subjects simulation design, the Spanish SIRS was found to produce reliable results with small standard errors of measurement. Regarding validity, very large effect sizes (mean Cohen's d= 2.00) were observed between feigners and honest responders for the SIRS primary scales. We consider the potential role of the Spanish SIRS with reference to Spanish translations for other assessment instruments.

The Systemic Inflammatory Response Syndrome (SIRS in acutely hospitalised medical patients: a cohort study

Directory of Open Access Journals (Sweden)

Storgaard Merete

2009-12-01

Full Text Available Abstract Background Sepsis is an infection which has evoked a systemic inflammatory response. Clinically, the Systemic Inflammatory Response Syndrome (SIRS is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in medical emergency ward patients is unknown. Methods We conducted a prospective cohort study of the frequency of SIRS and its relationship to sepsis and death among acutely hospitalised medical patients. In 437 consecutive patients, SIRS status, blood pressure, infection and comorbidity on admission was registered together with 28-day mortality. Results A hundred and fifty-four patients (35% had SIRS on admission, 211 patients (48% had no SIRS, and 72 patients (16% had insufficient data to evaluate their SIRS status. SIRS patients were 2.2 times more frequently infected, with 66/154 SIRS patients versus 41/211 non-SIRS patients: p Conclusion We found SIRS status on admission to be moderately associated with infection and strongly related to 28-day mortality.

Bohuslav Martinů und der intellektuelle Skeptizismus

OpenAIRE

Jonté, Gabriele

2010-01-01

Those engaged in research on Bohuslav Martinů are not uncommonly viewed with amusement by Germano-centric musicology. Here Martinů’s aesthetic of ‘Latin’ clarity and simplicity comes up against opposition that does not seem justifiable through purely rational considerations. It was Martinů’s special desire to avoid exaggerated pathos and false tragedy; rather, music was to convey joy – in the sense of his models Mozart and Dvořák. Martinů speaks of ‘poetry’ and ‘absolute beauty’ as the ‘hi...

SirT1 regulates energy metabolism and response to caloric restriction in mice.

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Gino Boily

Full Text Available The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utilize ingested food. These mice are hypermetabolic, contain inefficient liver mitochondria, and have elevated rates of lipid oxidation. When challenged with a 40% reduction in caloric intake, normal mice maintained their metabolic rate and increased their physical activity while the metabolic rate of SirT1-null mice dropped and their activity did not increase. Moreover, CR did not extend lifespan of SirT1-null mice. Thus, SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction.

33 CFR 147.817 - Sir Douglas Morpeth Tension Leg Platform safety zone.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Sir Douglas Morpeth Tension Leg... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.817 Sir Douglas Morpeth Tension Leg Platform safety zone. (a) Description. The Sir Douglas Morpeth Tension Leg Platform (Morpeth...

New Processing of Spaceborne Imaging Radar-C (SIR-C) Data

Science.gov (United States)

Meyer, F. J.; Gracheva, V.; Arko, S. A.; Labelle-Hamer, A. L.

2017-12-01

The Spaceborne Imaging Radar-C (SIR-C) was a radar system, which successfully operated on two separate shuttle missions in April and October 1994. During these two missions, a total of 143 hours of radar data were recorded. SIR-C was the first multifrequency and polarimetric spaceborne radar system, operating in dual frequency (L- and C- band) and with quad-polarization. SIR-C had a variety of different operating modes, which are innovative even from today's point of view. Depending on the mode, it was possible to acquire data with different polarizations and carrier frequency combinations. Additionally, different swaths and bandwidths could be used during the data collection and it was possible to receive data with two antennas in the along-track direction.The United States Geological Survey (USGS) distributes the synthetic aperture radar (SAR) images as single-look complex (SLC) and multi-look complex (MLC) products. Unfortunately, since June 2005 the SIR-C processor has been inoperable and not repairable. All acquired SLC and MLC images were processed with a course resolution of 100 m with the goal of generating a quick look. These images are however not well suited for scientific analysis. Only a small percentage of the acquired data has been processed as full resolution SAR images and the unprocessed high resolution data cannot be processed any more at the moment.At the Alaska Satellite Facility (ASF) a new processor was developed to process binary SIR-C data to full resolution SAR images. ASF is planning to process the entire recoverable SIR-C archive to full resolution SLCs, MLCs and high resolution geocoded image products. ASF will make these products available to the science community through their existing data archiving and distribution system.The final paper will describe the new processor and analyze the challenges of reprocessing the SIR-C data.

Online-Spiel-Besprechung: Martin Luthers Abenteuer

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Lisa Holzer

2015-03-01

Full Text Available Das Spiel "Martin Luthers Abenteuer" ist an Kinder im Grundschulalter gerichtet und vermittelt auf spielerische Weise die Geschichte der Reformation. Das Eintauchen in Martin Luthers Welt ermöglicht der Zielgruppe neben dem Gewinn neuen Wissens Unterhaltung und Spielspaß.

Martin Pärn Kunstihoone salongis

Index Scriptorium Estoniae

1999-01-01

15. 03 Martin Pärna mööbligrupi "Martin" presentatsioon. 1998. a. pälvis M. Pärn Euroopa disainipreemia Best in the Best Rote Punkt, mida jagab Design Zentrum Nordrhein Westfalen. 1999. a. parim on M. Pärna Martela OY-le projekteeritud klapplaud. Aasta Design Team - Philipsi disaini meeskond. Äramärgitud tooted on näitusel Nordrhein Westfaleni Design Zentrumis

Purple martins in oak woodlands

Science.gov (United States)

Brian D. C. Williams

2002-01-01

Purple martins are cavity-nesting swallows that once nested fairly widely in California’s oak woodlands but are now rare in that habitat. The old oaks of the Tehachapi Range (southern Sierra Nevada) may now host the last martins that nest in oak woodlands, with approximately 100-200 pairs or about 15 percent of the California population. In summer of 2000, we found 57...

Development of SIR-C Ground Calibration Equipment

Science.gov (United States)

Freeman, A.; Azeem, M.; Haub, D.; Sarabandi, K.

1993-01-01

SIR-C/X-SAR is currently scheduled for launch in April 1994. SIR-C is an L-Band and C-Band, multi-polarization spaceborne SAR system developed by NASA/JPL. X- SAR is an X-Band SAR system developed by DARA/ASI. One of the problems involved in calibrating the SIR-C instrument is to make sure that the horizontal (H) and vertical (V) polarized beams are aligned in the azimuth direction, i.e.. that they are pointing in the same direction. This is important if the polarimetric performance specifications for the system are to be met. To solve this problem, we have designed and built a prototype of a low-cost ground receiver capable of recording received power from two antennas, one H-polarized, the other V-polarized. The two signals are mixed to audio then recorded on the left and right stereo channels of a standard audio cassette player. The audio cassette recording can then be played back directly into a Macintosh computer, where it is digitized. Analysis of.

Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.

Science.gov (United States)

Gallo, Christopher M; Smith, Daniel L; Smith, Jeffrey S

2004-02-01

The Saccharomyces cerevisiae Sir2 protein is an NAD(+)-dependent histone deacetylase (HDAC) that functions in transcriptional silencing and longevity. The NAD(+) salvage pathway protein, Npt1, regulates Sir2-mediated processes by maintaining a sufficiently high intracellular NAD(+) concentration. However, another NAD(+) salvage pathway component, Pnc1, modulates silencing independently of the NAD(+) concentration. Nicotinamide (NAM) is a by-product of the Sir2 deacetylase reaction and is a natural Sir2 inhibitor. Pnc1 is a nicotinamidase that converts NAM to nicotinic acid. Here we show that recombinant Pnc1 stimulates Sir2 HDAC activity in vitro by preventing the accumulation of NAM produced by Sir2. In vivo, telomeric, rDNA, and HM silencing are differentially sensitive to inhibition by NAM. Furthermore, PNC1 overexpression suppresses the inhibitory effect of exogenously added NAM on silencing, life span, and Hst1-mediated transcriptional repression. Finally, we show that stress suppresses the inhibitory effect of NAM through the induction of PNC1 expression. Pnc1, therefore, positively regulates Sir2-mediated silencing and longevity by preventing the accumulation of intracellular NAM during times of stress.

Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states.

Directory of Open Access Journals (Sweden)

Stephanie Kueng

Full Text Available Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM loci in budding yeast. We have performed a detailed biochemical and genetic analysis of the largest Sir protein, Sir4. The N-terminal half of Sir4 is dispensable for SIR-mediated repression of HM loci in vivo, except in strains that lack Yku70 or have weak silencer elements. For HM silencing in these cells, the C-terminal domain (Sir4C, residues 747-1,358 must be complemented with an N-terminal domain (Sir4N; residues 1-270, expressed either independently or as a fusion with Sir4C. Nonetheless, recombinant Sir4C can form a complex with Sir2 and Sir3 in vitro, is catalytically active, and has sedimentation properties similar to a full-length Sir4-containing SIR complex. Sir4C-containing SIR complexes bind nucleosomal arrays and protect linker DNA from nucleolytic digestion, but less effectively than wild-type SIR complexes. Consistently, full-length Sir4 is required for the complete repression of subtelomeric genes. Supporting the notion that the Sir4 N-terminus is a regulatory domain, we find it extensively phosphorylated on cyclin-dependent kinase consensus sites, some being hyperphosphorylated during mitosis. Mutation of two major phosphoacceptor sites (S63 and S84 derepresses natural subtelomeric genes when combined with a serendipitous mutation (P2A, which alone can enhance the stability of either the repressed or active state. The triple mutation confers resistance to rapamycin-induced stress and a loss of subtelomeric repression. We conclude that the Sir4 N-terminus plays two roles in SIR-mediated silencing: it contributes to epigenetic repression by stabilizing the SIR-mediated protection of linker DNA; and, as a target of phosphorylation, it can destabilize silencing in a regulated manner.

SIR-ZEE: plataforma tecnológica para el desarrollo local SIR-ZEE: technology platform for local development

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Marlen Treviño Villalobos

2012-11-01

Full Text Available El Sistema de Información Regional de la Zona Económica Especial (SIR-ZEE nació en Costa Rica aproximadamente en 1998, cuando se concibió la idea de crear un sistema informático para recopilar, gestionar y ofrecer temáticas generadas en forma digital por diferentes entidades públicas y privadas. En el 2008, con los fondos del Programa de Regionalización Interuniversitaria del Consejo Nacional de Rectores, se aprobó la iniciativa SIR-ZEE, Plataforma Tecnológica para el Desarrollo Local, que buscó fortalecer las capacidades productivas y las capacidades de gobernabilidad en la Región Huetar Norte mediante el acceso a la información oportuna y relevante para el desarrollo económico local. Este artículo tiene como objetivo mostrar no solo la relevancia de un sistema de información en la planificación del desarrollo local, sino también que, en la actualidad, el SIR-ZEE se está convirtiendo en una ventaja competitiva para la Región Huetar Norte, ya que facilita el proceso de toma decisiones. Los principales resultados obtenidos al final de la iniciativa fueron una propuesta metodológica para la elaboración de planes estratégicos de desarrollo local en la Región Huetar Norte, la sensibilización de los actores locales sobre la participación ciudadana en las diferentes fases de la planificación, un diagnóstico territorial con el valor agregado de contar con la información georreferenciada y disponible en un sitio web, y avances en la elaboración del Plan estratégico de desarrollo local.The Regional Information System of the Special Economic Zone (SIR-ZEE was born about the year 1998 as a computer system to collect, manage and offer thematic generated in digital format by different public and private entities. In 2008, with the funds of Interuniversity Regionalization Program the National Council of Rectors approved the initiative SIR- ZEE: Platform Technology for Local Development which sought to strengthen productive

Geim, Prof. Sir Andre Konstantin

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...

Sir John Meurig Thomas.

Science.gov (United States)

Thomas, John Meurig

2013-10-11

"My greatest achievement has been to combine being a teacher, a researcher, and a popularizer of science for over 50 years. My worst nightmare is to find myself dumbstruck when I am about to give a lecture …︁" This and more about Sir John Meurig Thomas can be found on page 10938. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bertlmann-Martin inequalities in hypernuclei

International Nuclear Information System (INIS)

Lombard, R.J.; Marcos, S.; Mares, J.

1994-01-01

Inequalities have been established by Bertlmann and Martin which link the rms radius and the kinetic energy of the 1s orbit to the lowest dipole transition energy. The derivation is based on the Thomas-Reiche-Kuhn sum rule, which requires a local Hamiltonian. In the present work, we extend these inequalities to Hamiltonian where the nonlocality can be expressed via spatial dependent effective mass. We discuss the case of hypernuclei, which provides a suitable example to verify the Bertlmann-Martin inequalities

Sir Karl Popper and Education

Science.gov (United States)

McNamara, D. R.

1978-01-01

Sir Karl Popper is one of England's most distinguished contemporary philosophers and it is surprising that his thought has not permeated and informed educational discussion. This paper suggests that educationists have much to learn from Karl Popper's writings and explores ways in which his ideas can illuminate and advance discussion about…

Thomas, Prof. Sir John Meurig

Indian Academy of Sciences (India)

Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage ... Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more.

Constitutive Relation of Engineering Material Based on SIR Model and HAM

Directory of Open Access Journals (Sweden)

Haoxiang He

2014-01-01

Full Text Available As an epidemic mathematical model, the SIR model represents the transition of the Susceptible, Infected, and Recovered. The profound implication of the SIR model is viewed as the propagation and dynamic evolutionary process of the different internal components and the characteristics in a complex system subject to external effect. The uniaxial stress-strain curve of engineering material represents the basic constitutive relation, which also represents the damage propagation in the units of the damaged member. Hence, a novel dynamic stress-strain model is established based on the SIR model. The analytical solution and the approximate solution for the proposed model are represented according to the homotopy analysis method (HAM, and the relationship of the solution and the size effect and the strain rate is discussed. In addition, an experiment on the size effect of confined concrete is carried out and the solution of SIR model is suitable for simulation. The results show that the mechanical mechanism of the parameters of the uniaxial stress-strain model proposed in this paper reflects the actual characteristics of the materials. The solution of the SIR model can fully and accurately show the change of the mechanical performance and the influence of the size effect and the strain rate.

Pomeranchuk Prize awarded to André Martin

CERN Multimedia

Jordan Juras

2010-01-01

Professor André Martin has been awarded the I.Ya.Pomeranchuk Prize 2010, alongside Professor Valentine Zakharov.   André Martin, CERN theorist, pictured at the ceremony held in honour of his 80th birthday (August 2009). Established by the Institute of Theoretical and Experimental Physics (ITEP) in memory of an outstanding scientist Isaak Yakovlevich Pomeranchuk, the prize is awarded for the study of analytic properties of the scattering amplitude; which lead to the Froissart—Martin bound on the cross section growth with energy. The prize comes as a great honor for Martin, who was in fact a good friend of Mr. Pomeranchuk, "I am surprised and delighted to learn that I will be receiving the 2010 Pomeranchuk Prize. I was an admirer of Pomeranchuk and we shared a great friendship. I met with him for the last time in Erevan (Armenia) in 1965. As a good-bye, he told me, 'Analyticity exists'. This is precisely what I proved to earn the prize"....

Scientific objectives and selection of targets for the SMART-1 Infrared Spectrometer (SIR)

Science.gov (United States)

Basilevsky, A. T.; Keller, H. U.; Nathues, A.; Mall, U.; Hiesinger, H.; Rosiek, M.

2004-12-01

The European SMART-1 mission to the Moon, primarily a testbed for innovative technologies, was launched in September 2003 and will reach the Moon in 2005. On board are several scientific instruments, including the point-spectrometer SMART-1 Infrared Spectrometer (SIR). Taking into account the capabilities of the SMART-1 mission and the SIR instrument in particular, as well as the open questions in lunar science, a selection of targets for SIR observations has been compiled. SIR can address at least five topics: (1) Surface/regolith processes; (2) Lunar volcanism; (3) Lunar crust structure; (4) Search for spectral signatures of ices at the lunar poles; and (5) Ground truth and study of geometric effects on the spectral shape. For each topic we will discuss specific observation modes, necessary to achieve our scientific goals. The majority of SIR targets will be observed in the nadir-tracking mode. More than 100 targets, which require off-nadir pointing and off-nadir tracking, are planned. It is expected that results of SIR observations will significantly increase our understanding of the Moon. Since the exact arrival date and the orbital parameters of the SMART-1 spacecraft are not known yet, a more detailed planning of the scientific observations will follow in the near future.

King, Prof. Sir David Anthony

Indian Academy of Sciences (India)

Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.

Political Theology in Martin Luther

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Wanderley Pereira da Rosa

2016-12-01

Full Text Available The text Political Theology in Martin Luther intends to present the Lutheran political ethics based on the main treatises of the German reformer in this respect. We will also rely on scholars and historians of the Lutheran thought, who interpret that in different points of view, in order to support our position. In Martin Luther's writings we shall first identify a clear attack on papal authority and the Roman Curia, and their pretensions to universal sovereignty over all instances of life. It will be demonstrated that Martin Luther departs from this harsh attack on papal authority and an uncompromising defense of obedience to secular authority in his earliest years, to a position distinct from that. This first positioning of Luther was a result of his interpretation of the Bible, especially New Testament texts such as Romans 13 and Matthew 22:21. In his more mature period, Luther begins to make a defense of peaceful resistance towards the unjust authority and hence, to armed resistance against the tyrant, when this tyrant threatens the Christian faith.

90Sr content in 90Y-labeled SIR-spheres and Zevalin.

Science.gov (United States)

Metyko, John; Erwin, William; Poston, John; Jimenez, Sandra

2014-11-01

Three different 90Y internally administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures atMD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize 90Y-labeled microspheres, while Zevalin is an 90Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from 90Y production methods. The 90Y in SIR-Spheres and Zevalin are produced from a 90Sr/90Y generator, which leaves measurable quantities of 90Sr in the final product. TheraSphere 90Y is produced in a nuclear reactor which results in a large number of impurities, most notably 88Y and 91Y. Product information sheets reference these impurities with specific limits given. These limits represent a tiny fraction of the total product activity, and in the case of TheraSphere and SIR-Spheres gamma-emitting impurities, this has been verified in the literature. An analysis of 90Sr impurities in SIR-Spheres and Zevalin is presented in this paper. Impurity quantities were found to be within the vendors’ documented limits.

Martin Schwarzschild (1912 - 1997)

Science.gov (United States)

Pfau, Werner

The Chairman of the Astronomische Gesellschaft honored Martin Schwarzschild, who was the first to be presented with the Karl Schwarzschild Medal of the Astronomische Gesellschaft in 1957. An account of his life and work is given.

Whither Sir William?

Directory of Open Access Journals (Sweden)

Stephen J. Greenberg, MSLS, PhD

2017-04-01

Full Text Available There are times when something is simply so familiar that we can no longer see it at all. It can be a story, or a concept, or even a flesh-and-blood person. Familiarity breeds not only contempt, but a kind of invisibility as well. For too many of us, such is the case with Sir William Osler. In his time (1849–1919, many considered him to be one of the greatest practitioners, teachers, and writers ever in the field of medicine. He was instrumental in the founding of the Medical Library Association (MLA and was elected its second president.

SIRS Digues 2.0: A Cooperative Software For Levees Management

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Moins Isabelle

2016-01-01

Full Text Available SIRS Digues is a computing tool that makes informations on levees more durable and accessible in order to enhance their management. The first version of the software, which was IRSTEA’s initiative, was deployed in 2004. The second version was released in 2015. This article aims at pointing out the innovative aspects of this last version. They concern thematic and functionalities, computing technics and architecture, and last but not least, the business model chosen in order to build a long lasting software. The software’s kernel is sketched to propose a general description of levees: it focuses on description of the levees and linked objects, on disorders that affects them, on works... Most of these topics were already broached by the first version. The kernel of the version 2 may be extended using optional thematic modules. These modules concern: vegetation monitoring, reporting (in coherence with current French regulatory requirements, riverbanks, riverbed... Main functionnalities perfomed by SIRS Digues V1 and V2 are : data structuring and centralisation, quick access to relevant data, reporting and mapping, etc. SIRS Digues 2.0 updates and improves already existing functionalities of the first version. SIRS Digues V2 relies on an documentoriented NoSQL database, CouchDB, and on geospatial libraries, Geotoolkit and Apache-SIS. SIRS Digues V2 was released with a copyleft license. Copyrights belong to the French levees managers’ society, “France Digues”, which acts as a cooperative. Members put their heads together in order to gather their financial capacities and fund software development. France Digues has got the technical and thematic expertise and supply various services to the members. This business model aims to ensure accessibility, durability and adaptability of the software.

78 FR 5247 - Martin Luther King, Jr., Federal Holiday, 2013

Science.gov (United States)

2013-01-24

..., 2013 Martin Luther King, Jr., Federal Holiday, 2013 By the President of the United States of America A... thousands upon thousands rallying for jobs and freedom, the Reverend Dr. Martin Luther King, Jr., delivered... Constitution and the laws of the United States, do hereby proclaim January 21, 2013, as the Martin Luther King...

C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.

Science.gov (United States)

Chiang, Wei-Chung; Tishkoff, Daniel X; Yang, Bo; Wilson-Grady, Joshua; Yu, Xiaokun; Mazer, Travis; Eckersdorff, Mark; Gygi, Steven P; Lombard, David B; Hsu, Ao-Lin

2012-09-01

FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4--homolog of mammalian SIRT6 and SIRT7 proteins--promotes DAF-16-dependent transcription and stress-induced DAF-16 nuclear localization. SIR-2.4 is required for resistance to multiple stressors: heat shock, oxidative insult, and proteotoxicity. By contrast, SIR-2.4 is largely dispensable for DAF-16 nuclear localization and function in response to reduced insulin/IGF-1-like signaling. Although acetylation is known to regulate localization and activity of mammalian FoxO proteins, this modification has not been previously described on DAF-16. We find that DAF-16 is hyperacetylated in sir-2.4 mutants. Conversely, DAF-16 is acetylated by the acetyltransferase CBP-1, and DAF-16 is hypoacetylated and constitutively nuclear in response to cbp-1 inhibition. Surprisingly, a SIR-2.4 catalytic mutant efficiently rescues the DAF-16 localization defect in sir-2.4 null animals. Acetylation of DAF-16 by CBP-1 in vitro is inhibited by either wild-type or mutant SIR-2.4, suggesting that SIR-2.4 regulates DAF-16 acetylation indirectly, by preventing CBP-1-mediated acetylation under stress conditions. Taken together, our results identify SIR-2.4 as a critical regulator of DAF-16 specifically in the context of stress responses. Furthermore, they reveal a novel role for acetylation, modulated by the antagonistic activities of CBP-1 and SIR-2.4, in modulating DAF-16 localization and function.

(Re)writing histories / Martin Klenn

Index Scriptorium Estoniae

Krenn, Martin, 1970-

2010-01-01

Martin Krenni kunstiprojektid linnaruumis - Monument for the Defeat. Time of liberation 1945-1947, Monument of the Aryanisation, Tirana Tours (2007). Ettekanne rahvusvahelisel seminaril Tallinnas 2009. a.

Jakob Martin Strid, Little Frog

DEFF Research Database (Denmark)

Skyggebjerg, Anna Karlskov

2008-01-01

En præsentation af Jakob Martins Strids billedbog Lille frø (2005). Bogen fungerer som et eksempel på en nyere billedbog, der indskriver sig i en dansk/nordisk traditionen af antiautoritære og nonsensprægede fortællinger med oprør mod forældre og samfundsinstitutioner.......En præsentation af Jakob Martins Strids billedbog Lille frø (2005). Bogen fungerer som et eksempel på en nyere billedbog, der indskriver sig i en dansk/nordisk traditionen af antiautoritære og nonsensprægede fortællinger med oprør mod forældre og samfundsinstitutioner....

SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

Directory of Open Access Journals (Sweden)

Chi-Hsien Peng

2010-06-01

Full Text Available Retinal stem cells bear potency of proliferation, self-renewal, and differentiation into many retinal cells. Utilizing appropriate sensors one can effectively detect the self-renewal and aging process abilities. Silencing information regulator (SirT1, a member of the sirtuin family, is a NAD-dependent histone deacetylase and an essential mediator for longevity in normal cells by calorie restriction. We firstly investigate the SirT1 mRNA expression in retinal stem cells from rats and 19 human eyes of different ages. Results revealed that SirT1 expression was significantly decreased in in vivo aged eyes, associated with poor self-renewal abilities. Additionally, SirT1 mRNA levels were dose-dependently increased in resveratrol- treated retinal stem cells. The expression of SirT1 on oxidative stress-induced damage was significantly decreased, negatively correlated with the level of intracellular reactive oxygen species production. Treatment with resveratrol could effectively further reduce oxidative stress induced by H2O2 treatment in retinal stem cells. Importantly, the anti-oxidant effects of resveratrol in H2O2-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1. SirT1 expression provides a feasible sensor in assessing self-renewal and aging process in retinal stem cells. Resveratrol can prevent reactive oxygen species-induced damages via increased retinal SirT1 expression.

"Cet obscur objet du Désir"

Directory of Open Access Journals (Sweden)

Reto Melchior

1996-09-01

Full Text Available Luis Bunuel’s last film is based on Pierre Louÿs’ La Femme et le Pantin. This now forgotten bestseller, published in 1898, is drawn from Goya s painting El Pelele, in which four women are playing with a male puppet. In Pierre Louÿs’ novel this scene is inverted so that one woman with two faces plays with four men. In Cet Obscur Objet du Désir this “femme fatale” is interpreted by two actresses. The concentric structure of the film puts focus on a scene of being excluded from knowing. The technique of continually interrupting the flash-back sequences frustrates the audience because of its exclusion from the “real” course of events and gives rise to doubts whether the male protagonist tells the truth about his love-affair or whether he satisfies the curiosity of the audience by telling them Pierre Louÿs’ novel as his own story. This ambiguous art of narration mirrors Bunuel’s claim that the main topic of Cet Obscur Objet du Désir is frustration.

Sir Charles Scott Sherrington (1857–1952)

Indian Academy of Sciences (India)

Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from twentytwouniversities and ...

Sir Charles Scott Sherrington (1857–1952)

Indian Academy of Sciences (India)

2016-08-26

Aug 26, 2016 ... Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from ...

Sir Ronald Ross and the Malarial Parasite

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 7. Sir Ronald Ross and the Malarial Parasite - Discovery of its Route - From Man to Mosquito and Back. Shobhona Sharma. General Article Volume 11 Issue 7 July 2006 pp 4-13 ...

Sir Isaac Newton

Directory of Open Access Journals (Sweden)

E. A. Venter

1964-03-01

Full Text Available Die geweldige oplewing van die Christelike wetenskaps- gedagte in ons geeslose tyd, is ongetwyfeld ’n haas onverklaar- bare verskynsel. Dwarsdeur die eeue het Christene ook wetenskap beoefen saam met ongelowiges, maar dit was eers in ons leeftyd dat die principia van die Christelike religie ook vrugbaar gemaak is vir die wetenskapsbeoefening. In hierdie verband sal die name van Dooyeweerd, Vollenhoven, Stoker e.a. steeds met eer vermeld word. Natuurlik het belydende Christene ook voorheen wel deeglik saamgewerk aan die gebou van die wetenskap. Die intieme verband tussen religie, wysbegeerte en wetenskaps­ beoefening is toe egter nog nie suiwer ingesien nie. Uit hier­ die tydperk dateer die arbeid van sir Isaac Newton.

Description of the male of Eburella pinima Martins and notes on the geographical distribution of Eburodacrys aenigma Galileo & Martins and Eburodacrys lanei Zajciw (Coleoptera, Cerambycidae

Directory of Open Access Journals (Sweden)

Juan Pablo Botero

2013-12-01

Full Text Available Description of the male of Eburella pinima Martins and notes on the geographical distribution of Eburodacrys aenigma Galileo & Martins and Eburodacrys lanei Zajciw (Coleoptera, Cerambycidae. The male of Eburella pinima Martins, 1997 is described and illustrated for the first time. Information on Eburodacrys aenigma Galileo & Martins, 2006, previously known only from the female holotype, which lacked locality label, is herein complemented. This species is recorded from Brazil and the male is depicted for the first time. The geographical distribution of Eburodacrys lanei Zajciw, 1958 is further restricted here as some previous records are confirmed to result from misidentifications of E. aenigma.

Sir Ronald Ross and the Malarial Parasite

Indian Academy of Sciences (India)

1997-08-20

Aug 20, 1997 ... In 1857, a General in the Indian Army, Sir C C G Ross and his wife Matilda .... generally low-caste Indians who required a fee before drinking the water and ... nary demand being made upon their systems, as by fatigue, chill,.

21. sajandi mammut / Martin Rästa ; intervjueerinud Tanel Veenre

Index Scriptorium Estoniae

Rästa, Martin, 1980-

2010-01-01

Kujundusgraafik Martin Rästaga (Mammut) tema tööst, loomingust, trendidest, graafilise disaini näituse eesmärkidest jm. Martin Rästa plakatite näitus "MMMT10" Tartu Y-galeriis 29. märtsist 10. aprillini 2010

The January 2006 Volcanic-Tectonic Earthquake Swarm at Mount Martin, Alaska

Science.gov (United States)

Dixon, James P.; Power, John A.

2009-01-01

On January 8, 2006, a swarm of volcanic-tectonic earthquakes began beneath Mount Martin at the southern end of the Katmai volcanic cluster. This was the first recorded swarm at Mount Martin since continuous seismic monitoring began in 1996. The number of located earthquakes increased during the next four days, reaching a peak on January 11. For the next two days, the seismic activity decreased, and on January 14, the number of events increased to twice the previous day's total. Following this increase in activity, seismicity declined, returning to background levels by the end of the month. The Alaska Volcano Observatory located 860 earthquakes near Mount Martin during January 2006. No additional signs of volcanic unrest were noted in association with this earthquake swarm. The earthquakes in the Mount Martin swarm, relocated using the double difference technique, formed an elongated cluster dipping to the southwest. Focal mechanisms beneath Mount Martin show a mix of normal, thrust, and strike-slip solutions, with normal focal mechanisms dominating. For earthquakes more than 1 km from Mount Martin, all focal mechanisms showed normal faulting. The calculated b-value for the Mount Martin swarm is 0.98 and showed no significant change before, during, or after the swarm. The triggering mechanism for the Mount Martin swarm is unknown. The time-history of earthquake occurrence is indicative of a volcanic cause; however, there were no low-frequency events or observations, such as increased steaming associated with the swarm. During the swarm, there was no change in the b-value, and the distribution and type of focal mechanisms were similar to those in the period before the anomalous activity. The short duration of the swarm, the similarity in observed focal mechanisms, and the lack of additional signs of unrest suggest this swarm did not result from a large influx of magma within the shallow crust beneath Mount Martin.

Dr. Martin Luther King, Jr. as Spiritual Leader

Directory of Open Access Journals (Sweden)

Andrea Pierce

2013-09-01

Full Text Available The purpose of this paper is to explore Dr. Martin Luther King Jr.’s spiritual leadership through his “I Have a Dream” speech. The paper explores the three characteristics of spiritual leadership as posed by Fry’s (2003 spiritual leadership theory: vision, hope/faith and altruistic love. The research draws upon these characteristics through qualitative content analysis of Dr. Martin Luther King Jr.’s “I Have a Dream” speech to illustrate Dr. King’s leadership as that of a spiritual leader. The research advances the spiritual leadership theory by establishing Dr. Martin Luther King Jr. as a spiritual leader. Through the illustration of Dr. King’s spiritual leadership, the characteristics of a spiritual leader are given tangible understanding.

Mari Martin - vahelüli looja ja kandja vahel / Mari Martin ; intervjueerinud Tanel Veenre

Index Scriptorium Estoniae

Martin, Mari, 1983-

2009-01-01

Kalamari Promotioni tegevjuht, Tartu Ülikoolis majandust õppiv Mari Martin oma esimestest sammudest moemaailmas, kaubamärkide ReUse RePublic (premeeriti noorte äriideede võistlusel "Ajujaht 2009" 175000 krooniga) ja Tallinn Dolls loomisest, eesti disaineritest, unistustest seoses eesti disainiga

Martin Stutzmann: Editor, Teacher, Scientist and Friend

Science.gov (United States)

Cardona, Manuel

2005-03-01

On 2 January 1995 Martin Stutzmann became Editor-in-Chief of physica status solidi, replacing Professor E. Gutsche, who had led the journal through the stormy period involving the fall of the Iron Curtain, the unification of Germany and the change in its Eastern part, where physica status solidi was based, from socialism as found in the real world (a German concept) to real world capitalism. In 1995 it was thought that the process had been completed (we should have known better!) and after the retirement of Prof. Gutsche the new owners of physica status solidi (Wiley-VCH) decided that a change in scientific management was desirable to adapt to the new socio-political facts and to insure the scientific continuity of the journal.Martin had moved in 1993 from my department at the Max-Planck-Institute to Munich where he soon displayed a tremendous amount of science man- agement ability during the build-up of the Walter Schottky Institute. The search for a successor as Edi- tor-in-Chief was not easy: the job was not very glamorous after the upheavals which had taken place in the editorial world following the political changes. Somebody in the Editorial Boards must have suggested Martin Stutzmann. I am sure that there was opposition: one usually looks for a well-established person ready to leave his direct involvement in science and take up a new endeavor of a more administrative nature. Nevertheless, the powers that be soon realized that Martin was an excellent, if somewhat unconventional candidate who had enough energy to remain a topnotch scientist and to lead the journal in the difficult times ahead: he was offered the job. In the negotiations that followed, he insisted in getting the administrative structures that would allow him to improve the battered quality of the journal and to continue his scientific productivity. Today we are happy to see that he succeeded in both endeavors. The journal has since grown in size and considerably improved its quality.Martin

Permanence for a Delayed Nonautonomous SIR Epidemic Model with Density-Dependent Birth Rate

Directory of Open Access Journals (Sweden)

Li Yingke

2011-01-01

Full Text Available Based on some well-known SIR models, a revised nonautonomous SIR epidemic model with distributed delay and density-dependent birth rate was considered. Applying some classical analysis techniques for ordinary differential equations and the method proposed by Wang (2002, the threshold value for the permanence and extinction of the model was obtained.

SIR-2 Data Normalization and Integration with M3 Data

Science.gov (United States)

Grumpe, A.; Felder, M. P.; Wöhler, C.; Mall, U.

2013-09-01

The point spectrometer SIR-2 on Chandrayaan-1 provided radiance spectra integrated over circular footprints of 200 m diameter in the wavelength range 934-2410.8 nm in 256 channels [1]. To analyze SIR-2 reflectance spectra in their spatial context, a coregistration to Chandrayaan-1 M³ hyperspectral images [2] as well as a correction for topography and thermal emission are inevitable. The thermal and topographic correction procedure is based on the surface temperature and a digital elevation model (DEM) inferred from M³ data. The corrected reflectance spectra are then normalized to a standard illumination and viewing geometry.

Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression

International Nuclear Information System (INIS)

Chang, C.-J.; Hsu, C.-C.; Yung, M.-C.; Chen, K.-Y.; Tzao Ching; Wu, W.-F.; Chou, H.-Y.; Lee, Y.-Y.; Lu, K.-H.; Chiou, S.-H.; Ma, H.-I

2009-01-01

CD133-expressing glioma cells play a critical role in tumor recovery after treatment and are resistant to radiotherapy. Herein, we demonstrated that glioblastoma-derived CD133-positive cells (GBM-CD133 + ) are capable of self-renewal and express high levels of embryonic stem cell genes and SirT1 compared to GBM-CD133 - cells. To evaluate the role of SirT1 in GBM-CD133 + , we used a lentiviral vector expressing shRNA to knock-down SirT1 expression (sh-SirT1) in GBM-CD133 + . Silencing of SirT1 significantly enhanced the sensitivity of GBM-CD133 + to radiation and increased the level of radiation-mediated apoptosis. Importantly, knock-down of SirT1 increased the effectiveness of radiotherapy in the inhibition of tumor growth in nude mice transplanted with GBM-CD133 + . Kaplan-Meier survival analysis indicated that the mean survival rate of GBM-CD133 + mice treated with radiotherapy was significantly improved by Sh-SirT1 as well. In sum, these results suggest that SirT1 is a potential target for increasing the sensitivity of GBM and glioblastoma-associated cancer stem cells to radiotherapy.

Interview with Abel Laureate Sir Andrew J. Wiles

DEFF Research Database (Denmark)

Raussen, Martin Hubert; Skau, Christian

2017-01-01

Andrew J. Wiles is the recipient of the 2016 Abel Prize of the Norwegian Academy of Science and Letters. The interview was conducted by Martin Raussen And Christian Skau in Oslo on May 23, 2016, in conjunction with the Abel Prize celebration.......Andrew J. Wiles is the recipient of the 2016 Abel Prize of the Norwegian Academy of Science and Letters. The interview was conducted by Martin Raussen And Christian Skau in Oslo on May 23, 2016, in conjunction with the Abel Prize celebration....

Serum inflammatory markers in the elderly: are they useful in differentiating sepsis from SIRS?

Directory of Open Access Journals (Sweden)

Mahshid Talebi-Taher

2014-06-01

Full Text Available Differentiating sepsis from other noninfectious causes of systemic inflammation is often difficult in the elderly. The aim of this study was to evaluate the ability of C-reactive protein (CRP, Erythrocyte Sedimentation Rate (ESR, procalcitonin (PCT, and Interleukin-6 (IL-6 to identify elderly patients with sepsis. In this single center prospective observational study, we included all consecutive elderly patients admitted with suspected sepsis and systemic inflammatory response syndrome (SIRS in an emergency department. Blood samples for measuring CRP, PCT, IL-6, ESR and white blood cells (WBC count were taken at first day of admission. Sensitivity, specificity, positive and negative predictive values were calculated for each inflammatory markers being studied. A total of 150 elderly patients aged 65 and older, 50 with sepsis and 50 with SIRS, and fifty individuals in a normal health status were included. CRP exhibited the greatest sensitivity (98% and negative predictive value (98.6% and performed best in differentiating patients with sepsis from those with SIRS. In a receiver operating characteristic curve analysis, IL-6 performed best in distinguishing between SIRS and the control group (AUC 0.75, 95% CI. On the other hand, both CRP and ESR appeared to be a more accurate diagnostic parameter for differentiating sepsis from SIRS among elderly patients.

Sir William Jenner (1815-1898) and Queen Victoria.

Science.gov (United States)

Seddon, David; Queen Victoria

2004-08-01

This biographical note outlines the work of Sir William Jenner (1815-1898), court physician 1861-93 and President of the Royal College of Physicians 1881-8. He was the first to distinguish between typhoid and typhus both clinically and pathologically.

Conrad Martin Metzi ofordid

Index Scriptorium Estoniae

1998-01-01

20. XI 1998-31. I 1999 Tartu Kunstimuuseumis saksa graafiku Conrad Martin Metzi (1749-1827) ofortide näitus, mis jätkab Tartu Kunstimuuseumi pedagoogilise suunitlusega näituste sarja. Näitusel 19. sajandi alguse saksa reproduktsioonigraafika ئ ofortide seeria, mis on teostatud Michelangelo Sixtuse kabeli fresko "Viimane kohtupäev" järgi

Martin Luther, the Educator.

Science.gov (United States)

Hibler, Richard W.

1985-01-01

Presents a brief biography of Martin Luther, focusing on his work as a reformer of education. Discusses what is known of his childhood, his life in an Augustinian monastery, his posting of the 95 theses against the sale of indulgences and other abuses of the Catholic Church, and his call for universal compulsory schooling. (CT)

dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

Directory of Open Access Journals (Sweden)

Kushal Kr. Banerjee

2012-12-01

Full Text Available Sir2, an evolutionarily conserved NAD+-dependent deacetylase, has been implicated as a key factor in mediating organismal life span. However, recent contradictory findings have brought into question the role of Sir2 and its orthologs in regulating organismal longevity. In this study, we report that Drosophila Sir2 (dSir2 in the adult fat body regulates longevity in a diet-dependent manner. We used inducible Gal4 drivers to knock down and overexpress dSir2 in a tissue-specific manner. A diet-dependent life span phenotype of dSir2 perturbations (both knockdown and overexpression in the fat body, but not muscles, negates the effects of background genetic mutations. In addition to providing clarity to the field, our study contrasts the ability of dSir2 in two metabolic tissues to affect longevity. We also show that dSir2 knockdown abrogates fat-body dFOXO-dependent life span extension. This report highlights the importance of the interplay between genetic factors and dietary inputs in determining organismal life spans.

Energy Transition Initiative: Island Energy Snapshot - Saint Martin/Sint Maarten

Energy Technology Data Exchange (ETDEWEB)

2015-09-01

This profile provides a snapshot of the energy landscape of the northeast Caribbean island Saint Martin. The island is divided between two nations, France in the north (Saint-Martin) and the Netherlands in the south (Sint Maarten).

Comparison of QSOFA score and SIRS criteria as screening mechanisms for emergency department sepsis.

Science.gov (United States)

Haydar, Samir; Spanier, Matthew; Weems, Patricia; Wood, Samantha; Strout, Tania

2017-11-01

The Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) score has been shown to accurately predict mortality in septic patients and is part of recently proposed diagnostic criteria for sepsis. We sought to ascertain the sensitive of the score in diagnosing sepsis, as well as the diagnostic timeliness of the score when compared to traditional systemic inflammatory response syndrome (SIRS) criteria in a population of emergency department (ED) patients treated in the ED, admitted, and subsequently discharged with a diagnosis of sepsis. Electronic health records of 200 patients who were treated for suspected sepsis in our ED and ultimately discharged from our hospital with a diagnosis of sepsis were randomly selected for review from a population of adult ED patients (N=1880). Data extracted included the presence of SIRS criteria and the qSOFA score as well as time required to meet said criteria. In this cohort, 94.5% met SIRS criteria while in the ED whereas only 58.3% met qSOFA. The mean time from arrival to SIRS documentation was 47.1min (95% CI: 36.5-57.8) compared to 84.0min (95% CI: 62.2-105.8) for qSOFA. The median ED "door" to positive SIRS criteria was 12min and 29min for qSOFA. Although qSOFA may be valuable in predicting sepsis-related mortality, it performed poorly as a screening tool for identifying sepsis in the ED. As the time to meet qSOFA criteria was significantly longer than for SIRS, relying on qSOFA alone may delay initiation of evidence-based interventions known to improve sepsis-related outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.

Martin Parmas tantsusaatest : meid Luisaga ei saanud nunnumeetriga mõõta / Martin Parmas ; interv. Rainer Kerge

Index Scriptorium Estoniae

Parmas, Martin, 1984-

2007-01-01

Kanal 2 võistluslikus tantsusaates "Tantsud tähtedega" osalenud tantsupaar Luisa Värk ja Martin Parmas kaotasid finaalis tantsupaarile Koit Toome - Kerttu Tänav. Võistlustantsija endast ja saates osalemise kogemusest

Delineation of major geologic structures in Turkey using SIR-B data

Science.gov (United States)

Toksoz, M. N.; Pettengill, G. H.; Ford, P.; Gulen, L.

1984-01-01

Shuttle Imaging Radar-B (SIR-B) images of well mapped segments of major faults, such as the North Anatolian Fault (NAF) and East Anatolian Fault (EAF) will be studied to identify the prominent signatures that characterize the fault zones for those specific regions. The information will be used to delineate the unmapped fault zones in areas with similar geological and geomorphological properties. The data obtained from SIR-B images will be compared and correlated with the LANDSAT thematic mapper and seismicity alignments based on well constrained earthquake epicenters.

The non-marine Mollusca of St. Martin (Lesser Antilles)

NARCIS (Netherlands)

Coomans, H.E.

1967-01-01

After our studies about the marine mollusks of St. Martin, (COOMANS 1963a, 1963b), this publication will deal with the land and freshwater shells of the island. The non-marine mollusks of St. Martin were already fairly well known at the end of the last century (MAZÉ 1890, p. 22—34), who mentioned 36

76 FR 48049 - Airworthiness Directives; Lockheed Martin Corporation/Lockheed Martin Aeronautics Company Model L...

Science.gov (United States)

2011-08-08

... Aircraft Certification Office (ACO), 1701 Columbia Avenue, College Park, Georgia 30337; phone: 404- 474... Corporation/Lockheed Martin Aeronautics Company Model L-1011 Series Airplanes AGENCY: Federal Aviation... existing airworthiness directive (AD) that applies to Model L-1011-385-1, L-1011-385-1-14, and L-1011- 385...

SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells

International Nuclear Information System (INIS)

Xie Yuexia; Zhang Jianghong; Shao Chunlin; Xu Yanwu

2012-01-01

Intratumoral hypoxia is an important contributory factor to tumor cell resistance to radiotherapy. SirT1, a nicotinamide adenine dinucleotide (NAD + )-dependent histone/protein deacetylase, has been linked to the decrease of radiation-induced DNA damage and seems to be critical for cancer therapy. The purpose of this study was to investigate the role of SirT1 in hypoxia-induced radiation response on hepatoma cells. It was found that the administration with resveratrol, a putative SirT1 activator, enhanced the resistance of HepG2 cells against radiation-induced DNA damage of MN formation under hypoxia condition; while nicotinamide, a well-known SirT1 inhibitor, sensitized this radiation damage. Nevertheless, pretreatment of cells with 10058-F4, a specific inhibitor of c-Myc, almost eliminated the nicotinamide-induced radiosensitive effect. Further studies revealed that resveratrol inhibited c-Myc protein accumulation via up-regulation of SirT1 expression and deacetylase activity, and this loss of c-Myc protein was abolished by inhibiting its degradation in the presence of MG132, a potent inhibitor of proteasome. In contrast, nicotinamide attenuated c-Myc protein degradation induced by radiation under hypoxia through inhibition of SirT1 deacetylase activity. Our findings suggest that SirT1 could serve as a novel potent target of radiation-induced DNA damage and thus as a potential strategy to advance the efficiency of radiation therapy in hepatoma entities. (author)

The susceptible-infected-recovered (SIR) model for viral marketing

Science.gov (United States)

Ismail, Siti Suhaila; Akil, Ku Azlina Ku; Chulan, Majdah; Sharif, Noorzila

2017-11-01

Viral marketing is a marketing strategy utilizes social media to spread information about a product or services provided. It is the most powerful way to share information in a short amount of time. The objective of this study is to investigate the dynamic of viral marketing within a time duration in the point of view of mathematics. This study used the epidemiological model known as Susceptible-Infected-Recovered (SIR). The model consists of a system of three differential equations with three state variables namely susceptible (S), infected (I) and recovered (R). It considers a case of SIR model with demography. Numerical experiments have been performed. The results show that viral marketing reaches its peak within two days. The online messages shared will become higher if the initial number of the infected individual has been increased.

Sir Karl Popper and his philosophy of physics

Science.gov (United States)

Jammer, Max

1991-12-01

The eminent mathematical physicist Sir Hermann Bondi once said: “There is no more to science than its method, and there is no more to its method than Popper has said.” Indeed, many regard Sir Karl Raimund Popper the greatest philosopher of science in our generation. Much of what Popper “has said” refers to physics, but physicists, generally speaking, have little knowledge of what he has said. True, Popper's philosophy of science and, in particular, his realistic interpretation of quantum mechanics deviates considerably from the generally accepted doctrine. But as Popper, rightly I think, points out, it is precisely the proliferation of divergent theories which promotes the growth of scientific knowledge; it would be a danger for physics if physicists were dogmatically tied to a single theory or would not test their theory against alternatives. It is for this purpose that, on the occasion of the nonagenarian celebration of Popper's birthday, the present essay has been written.

Rees, Prof. Lord Martin (John)

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1991 Honorary. Rees, Prof. Lord Martin (John) FRS. Date of birth: 23 June 1942. Address: Emeritus professor of Cosmology & Astrophysics, Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA, U.K.. Contact: Office: (+44-1223) 33 7548

Martin Veinmann : eks televaataja tahab seebisarjas näha õnnelikku armastust / Martin Veinmann ; interv. Eveli Rebane

Index Scriptorium Estoniae

Veinmann, Martin

2008-01-01

TV3 draamaseriaali "Kodu keset linna" hooaja lõpp. Seriaalis üht peategelast Hannest kehastav Martin Veinmann endast ja oma rollitegelase suhetest. Lisaks "Hooaeg lõpeb lapserööviga" ja "Olulisemad süzheekäigud"

Verification of the linearity of the new SIR using sources of 64Cu and 99mTc

International Nuclear Information System (INIS)

Michotte, Carine

2012-02-01

The linearity of the new SIR electronics has been verified by looking for deviations from the exponential decay for several 64 Cu and 99m Tc sources. Data analyses are compared with the half-life used as a fixed or free parameter. It is concluded that no significant non-linearity is observed in the new SIR. For comparison, the same method has been applied to analyse existing data from the original SIR. (author)

Developments in electrochemistry science inspired by Martin Fleischmann

CERN Document Server

Pletcher, Derek; Williams, David

2014-01-01

Martin Fleischmann was truly one of the 'fathers' of modern electrochemistry having made major contributions to diverse topics within electrochemical science and technology. These include the theory and practice of voltammetry and in situ spectroscopic techniques, instrumentation, electrochemical phase formation, corrosion, electrochemical engineering, electrosynthesis and cold fusion.  While intended to honour the memory of Martin Fleischmann, Developments in Electrochemistry is neither a biography nor a history of his contributions. Rather, the book is a series of critical reviews of topic

Sir Robert Sidney’s Poems Revisited: the alternative sequence

OpenAIRE

Relvas, Maria de Jesus C.

1997-01-01

The essay approaches the lyric sequence written by Sir Robert Sidney (1563-1626) in the Elizabethan age, by mainly exploring its unique formal structure, which encloses an alternative sequence formed by a re-numbering of several poems.

Martin Rubin: Thrillers

OpenAIRE

Morsch, Thomas

2000-01-01

This book is the first in a new series from Cambridge University Press entitled Genres in American Cinema (general editor : Barry Keith Grant). The thriller has been a much-neglected genre in film studies (less so in literature), so any new work in this field is to be welcomed. Martin Rubin has successfully fulfilled the series'aim of providing « a comprehensive account of its genre... balancing theoretical and historical discussion with close readings of representative films » (p. iii). Yet ...

Clint Eastwood lõi Martin Scorseset

Index Scriptorium Estoniae

2005-01-01

Ameerika produtsentide gild nimetas aasta parimaks filmiks Martin Scorsese "Aviaatori" ja Ameerika filmilavastajate gild valis aasta parimaks režissööriks Clint Eastwoodi filmi eest "Miljoni dollari tibi" ("Million Dollar Baby")

SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation

International Nuclear Information System (INIS)

Xie, Yuexia; Tu, Wenzhi; Zhang, Jianghong; He, Mingyuan; Ye, Shuang; Dong, Chen; Shao, Chunlin

2015-01-01

Highlights: • γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells. • SirT1 played a protective role in regulating this bystander effect. • SirT1 contributed to the protective effects via elimination the accumulation of ROS. • The activity of c-Myc is critical for maintaining the protective role of SirT1. - Abstract: Radiation-induced bystander effect (RIBE) has important implications for secondary cancer risk assessment during cancer radiotherapy, but the bystander signaling processes, especially under hypoxic condition, are still largely unclear. The present study found that micronuclei (MN) formation could be induced in the non-irradiated HL-7702 hepatocyte cells after being treated with the conditioned medium from irradiated hepatoma HepG2 and SK-Hep-1 cells under either normoxia or hypoxia. This bystander response was dramatically diminished or enhanced when the SirT1 gene of irradiated hepatoma cells was overexpressed or knocked down, respectively, especially under hypoxia. Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation. But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference. Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion. These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved

SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation

Energy Technology Data Exchange (ETDEWEB)

Xie, Yuexia [Institute of Radiation Medicine, Fudan University, Shanghai (China); Central Laboratory, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai (China); Tu, Wenzhi; Zhang, Jianghong; He, Mingyuan; Ye, Shuang; Dong, Chen [Institute of Radiation Medicine, Fudan University, Shanghai (China); Shao, Chunlin, E-mail: clshao@shmu.edu.cn [Institute of Radiation Medicine, Fudan University, Shanghai (China)

2015-02-15

Highlights: • γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells. • SirT1 played a protective role in regulating this bystander effect. • SirT1 contributed to the protective effects via elimination the accumulation of ROS. • The activity of c-Myc is critical for maintaining the protective role of SirT1. - Abstract: Radiation-induced bystander effect (RIBE) has important implications for secondary cancer risk assessment during cancer radiotherapy, but the bystander signaling processes, especially under hypoxic condition, are still largely unclear. The present study found that micronuclei (MN) formation could be induced in the non-irradiated HL-7702 hepatocyte cells after being treated with the conditioned medium from irradiated hepatoma HepG2 and SK-Hep-1 cells under either normoxia or hypoxia. This bystander response was dramatically diminished or enhanced when the SirT1 gene of irradiated hepatoma cells was overexpressed or knocked down, respectively, especially under hypoxia. Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation. But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference. Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion. These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved.

SIR JOHN CRAWFORD MEMORIAL ADDRESS: Agriculture: The challenges of the 21st century

OpenAIRE

Beddington, Sir John

2012-01-01

The Sir John Crawford Memorial Address has been presented since 1985, in honour of the distinguished Australian civil servant, educator and agriculturalist in whose name the Crawford Fund was established. Sir John Crawford was a remarkable Australian who contributed at the highest levels, and was a passionate supporter of international agricultural research for development. This talk draws attention to four current and interrelated trends that suggest the world will be rather different by 202...

Stability analysis of the Euler discretization for SIR epidemic model

International Nuclear Information System (INIS)

Suryanto, Agus

2014-01-01

In this paper we consider a discrete SIR epidemic model obtained by the Euler method. For that discrete model, existence of disease free equilibrium and endemic equilibrium is established. Sufficient conditions on the local asymptotical stability of both disease free equilibrium and endemic equilibrium are also derived. It is found that the local asymptotical stability of the existing equilibrium is achieved only for a small time step size h. If h is further increased and passes the critical value, then both equilibriums will lose their stability. Our numerical simulations show that a complex dynamical behavior such as bifurcation or chaos phenomenon will appear for relatively large h. Both analytical and numerical results show that the discrete SIR model has a richer dynamical behavior than its continuous counterpart

The Newest Monument: The Martin Luther King, Jr. National Memorial

Science.gov (United States)

Social Studies and the Young Learner, 2011

2011-01-01

This article features the newest monument, the Martin Luther King, Jr. National Memorial. The memorial on the National Mall in Washington, D.C., honoring Dr. Martin Luther King, Jr. will be an engaging landscape experience to convey four fundamental and recurring themes throughout Dr. King's life--democracy, justice, hope, and love. Natural…

Three Decades Investigating Humor and Laughter: An Interview With Professor Rod Martin.

Science.gov (United States)

Martin, Rod; Kuiper, Nicholas A

2016-08-01

Since the start of the 21st century, the investigation of various psychological aspects of humor and laughter has become an increasingly prominent topic of research. This growth can be attributed, in no small part, to the pioneering and creative work on humor and laughter conducted by Professor Rod Martin. Dr. Martin's research interests in humor and laughter began in the early 1980s and continued throughout his 32 year long career as a professor of clinical psychology at the University of Western Ontario. During this time, Dr. Martin published numerous scholarly articles, chapters, and books on psychological aspects of humor and laughter. Professor Martin has just retired in July 2016, and in the present interview he recounts a number of research highlights of his illustrious career. Dr. Martin's earliest influential work, conducted while he was still in graduate school, stemmed from an individual difference perspective that focused on the beneficial effects of sense of humor on psychological well-being. This research focus remained evident in many of Professor Martin's subsequent investigations, but became increasingly refined as he developed several measures of different components of sense of humor, including both adaptive and maladaptive humor styles. In this interview, Dr. Martin describes the conceptualization, development and use of the Humor Styles Questionnaire, along with suggestions for future research and development. In doing so, he also discusses the three main components of humor (i.e., cognitive, emotional and interpersonal), as well as the distinctions and similarities between humor and laughter. Further highlights of this interview include Professor Martin's comments on such diverse issues as the genetic versus environmental loadings for sense of humor, the multifaceted nature of the construct of humor, and the possible limitations of teaching individuals to use humor in a beneficial manner to cope with stress and enhance their social and

L’économie politique du désir dans le rituel et le militantisme au SriLanka

Directory of Open Access Journals (Sweden)

Wim Van Daele

2013-03-01

Full Text Available Le désir est au cœur des interactions complexes entre le développement et la religion. Cet article examine ses différentes expressions, comme étant une des préoccupations fondamentales de nombreuses religions, qui motivent à la fois le développement et les alternatives au développement. Au SriLanka, face au changement social, la forme néolibérale et mondialisée du développement est comprise et réinterprétée à travers des idiomes et des formations locales du désir. L’économie néolibérale cultive le désir et mène à un accroissement présumé de la présence des preta (fantômes affamés et avides qui se manifestent parfois au moment de la mort d’une personne. Les fantômes affamés, en tant que formations fétichisées du désir, trouvent un écho chez les consommateurs et les entrepreneurs, qui montrent unappétit insatiable vis-à-vis d’une richesse matérielle en constante croissance. Ainsi, l’apaisement ritualisé des fantômes affamés et le militantisme social de groupes tels que le Movement for National Land and Agricultural Reform (MONLAR sont clairement liés par leur préoccupation mutuelle face à l’insécurité existentielle des êtres humains et non humains, causée par un désir excessif et déséquilibré. L’action rituelle et le militantisme social divergent toutefois dans la formulation explicite de leurs préoccupations spécifiques concernant le désir. Le rituel matérialise et condense l’angoisse liée au désir, alors que le militantisme social décrit la fétichisation du désir en termes économiques, politiques et scientifiques plus abstraits.

Maailm lihtsalt vaatab pealt / Martin Herem

Index Scriptorium Estoniae

Herem, Martin, 1973-

2013-01-01

Kaitseväe Ühendatud Õppeasutuste ülem kolonel Martin Herem analüüsib metsavendlust näitena Eesti lähiajaloost, kuivõrd piiratud on väikeriigi võimalused suurriikliku terrori vastu võitlemiseks

Martin Continues His Homeland Security Profession with New UASI Position

OpenAIRE

Issvoran, Heather

2014-01-01

Bruce Martin has found a second act in homeland security. The fire services veteran and college educator is now Project Manager of the Bay Area Urban Areas Security Initiative (UASI), overseeing its Chemical, Biological, Radiological, Nuclear Explosives (CBRNE) program. Martin is a 2010 master’s degree graduate of the Naval Postgraduate School Center for Homeland Defense and Security.

Martin Luther oor oneerlikheid in die ekonomie

Directory of Open Access Journals (Sweden)

I.W.C. (Natie van Wyk

2015-07-01

Full Text Available Martin Luther about dishonesty in the economy. This article is about Martin Luther’s economic ethics. Background information is given about the economic situation 500 years ago. The high levels of poverty in Germany were the main reason behind the health crisis experienced at that time. Luther reprimanded the heads of families to work diligently and honestly in order to ensure a stable income for the family. He prophetically also criticised the dishonesty on the market place. He exposed the many attempts by people to exploit the poor. An overview is given of the development of his economic thought. The focus falls, however, on his essay Von Kaufshandlung und Wucher (1524 [On trade and profiteering].

Martin Skancke : kõigepealt on vaja parandada pangandussüsteemi / Martin Skancke ; interv. Mikk Salu

Index Scriptorium Estoniae

Skancke, Martin

2008-01-01

Norra valitsuse pensionifondi juht vastab küsimustele, mis on praeguse ülemaailmse finantskriisi põhjused, kuidas ülemaailmsest surutisest välja tulla, kui palju on Norra pensionifond sel aastal oma väärtust kaotanud, miks on Boeingusse või EADS-i investeerimine tema arvates ebaeetiline. Lisa: Martin Skancke - hiigelfondi juht

The Words of Martin Luther King, Jr.

Science.gov (United States)

Today's Education, 1979

1979-01-01

Excerpts from speeches by Dr. Martin Luther King, Jr., are reprinted. Topics discussed include discrimination, the South, education, nonviolent resistance, poverty, economic opportunity, and world peace. (LH)

Hoarding symptoms among psychiatric outpatients: confirmatory factor analysis and psychometric properties of the Saving Inventory – Revised (SI-R

Directory of Open Access Journals (Sweden)

Siau Pheng Lee

2016-10-01

Full Text Available Abstract Background The growing interest in problematic hoarding as an independent clinical condition has led to the development of the Saving Inventory-Revised (SI-R to assess hoarding phenomenology. The SI-R is one of the most widely used instruments to measure hoarding symptoms; however, it lacks validation in non-Western samples. Methods The current study examined the construct, convergent, and discriminant validity of the SI-R among 500 outpatients at a psychiatric hospital in Singapore. The three-factor structure solution of the SI-R was fitted in a confirmatory factor analysis. Results The final model achieved mediocre fit (χ2 = 1026.02, df = 186; RMSEA = 0.095, SRMR = 0.06; CFI = 0.86; NNFI = 0.85. Two reverse-coded items (items 2 and 4 were removed due to insufficient factor loadings, resulting in the modified 21-item SI-R (SIR-21. Our findings indicate the need to further examine the construct validity of the SI-R, particularly in non-Western samples. Nonetheless, correlations with other hoarding-related constructs, such as anxiety (Beck Anxiety Inventory and depression (Beck Depression Inventory-II, supported the convergent and discriminant validity of the SIR-21 in our sample. Conclusions Findings in our current majority Chinese sample were consistent with previous observations from other Chinese samples. Implications were discussed from a cross-cultural perspective, such as cultural emphasis on saving for future use and overlap between the concepts of discarding and acquiring in Chinese samples. Future studies should also examine differences among other ethnic groups (e.g., Malay, Indian.

Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions

Directory of Open Access Journals (Sweden)

Christian eLinke

2013-07-01

Full Text Available The Forkhead box family of transcription factors is evolutionary conserved from yeast to higher eukaryotes and its members are involved in many physiological processes including metabolism, DNA repair, cell cycle, stress resistance, apoptosis and aging. In budding yeast, four Forkhead transcription factors were identified, namely Fkh1, Fkh2, Fhl1, and Hcm1, which are implicated in chromatin silencing, cell cycle regulation and stress response. These factors impinge transcriptional regulation during cell cycle progression, and histone deacetylases play an essential role in this process, e.g. the nuclear localisation of Hcm1 depends on Sir2 activity, whereas Sin3/Rpd3 silence cell cycle specific gene transcription in G2/M phase. However, a direct involvement of Sir2 in Fkh1/Fkh2-dependent regulation of target genes is at present unknown. Here, we show that Fkh1 and Fkh2 associate with Sir2 in G1 and M phase, and that Fkh1/Fkh2-mediated activation of reporter genes is antagonized by Sir2. We further report that Sir2 overexpression strongly affects cell growth in an Fkh1/Fkh2-dependent manner. In addition, Sir2 regulates the expression of the mitotic cyclin Clb2 through Fkh1/Fkh2-mediated binding to the CLB2 promoter in G1 and M phase. We finally demonstrate that Sir2 is also enriched at the CLB2 promoter under stress conditions, and that the nuclear localization of Sir2 is dependent on Fkh1 and Fkh2. Taken together, our results show a functional interplay between Fkh1/Fkh2 and Sir2 suggesting a novel mechanism of cell cycle repression. Thus, in budding yeast, not only the regulation of G2/M gene expression but also the protective response against stress could be directly coordinated by Fkh1 and Fkh2.

Registered Replication Report : Strack, Martin, & Stepper

NARCIS (Netherlands)

Wagenmakers, E.-J.; Beek, T.; Dijkhoff, L.; Gronau, Q.F.; Acosta, A.; Adams, R.B.; Albohn, D.N.; Allard, E.S.; Benning, S.D.; Blouin-Hudon, E.-M.; Bulnes, L.C.; Caldwell, T.L.; Calin-Jageman, R.J.; Capaldi, C.A.; Carfagno, N.S.; Chasten, K.T.; Cleeremans, A.; Connell, L.; DeCicco, J. M.; Dijkstra, K.; Fischer, A.H.; Foroni, F.; Hess, U.; Holmes, K.J.; Jones, J.L.H.; Klein, O.; Koch, C.; Korb, S.; Lewinski, P.; Liao, J.D.; Lund, S.; Lupianez, J.; Lynott, D.; Nance, C.N.; Oosterwijk, S.; Ozdoğru, A.A.; Pacheco-Unguetti, A.P.; Pearson, B.; Powis, C.; Riding, S.; Roberts, T.A.; Rumiati, R.I.; Senden, M.; Shea-Shumsky, N.B.; Sobocko, K.; Soto, J.A.; Steiner, T.G.; Talarico, J.M.; van Allen, Z.M.; Vandekerckhove, M.; Wainwright, B.; Wayand, J.F.; Zeelenberg, R.; Zetzer, E.E.; Zwaan, R.A.

2016-01-01

According to the facial feedback hypothesis, people’s affective responses can be influenced by their own facial expression (e.g., smiling, pouting), even when their expression did not result from their emotional experiences. For example, Strack, Martin, and Stepper (1988) instructed participants to

Martin S. Kulli fenomen / Arno Oja

Index Scriptorium Estoniae

Oja, Arno, 1950-

2011-01-01

Kriitik Arno Oja küsib, kes on salapärane romaanikangelane ja harrastusajaloolane Martin S. Kull (kas Ervin Õunapuu?) ning annab hinnangu tema raamatutele "Tartu koonduslaager", "Tapva hämaruse päevaraamat" ja "Elmar Ilp. Veri mu kätel"

Prazdnik freski / Martin Kramer ; interv. Natalja Sindetskaja

Index Scriptorium Estoniae

Kramer, Martin

2002-01-01

Rahvusvahelisest fresko- ja mosaiigifestivalist Kiviõlis räägib festivali kunstiline juht sakslane Martin Kramer: festivali ideest, varemtehtust, põhjustest, miks valiti Eestis objektiks Kiviõli vene gümnaasium

Sir James Reid and the Death of Queen Victoria: An Early Model for End-of-Life Care.

Science.gov (United States)

Abrams, Robert C

2015-12-01

An appraisal of the last ten days of Queen Victoria's life, viewed primarily from the perspective of her personal physician, Sir James Reid, is presented. Sir James' clinical encounters with his patient and the Royal Family are examined to reveal his strategic and medical thinking and gauge his level of success in basic palliative aims. It was found that the lack of effective medical interventions, tensions within the Royal Family, the importance of his post to Sir James' professional career, and the political ramifications unavoidably connected with the illness of a head of state, all presented challenges to Reid's efforts to ease the physical and emotional pain of Queen Victoria's dying. Key features of Sir James' approach included reliance on physician-patient and physician-family relationships, emphasis on emotional support for the patient, and the careful selection of interventions for the family. In the first years of the 20th century, an era when the contemporary concepts of palliative care, hospice, and family dynamics did not exist, Sir James' management of the Queen's final illness suggested an early model for end-of-life care. By the end of Queen Victoria's life, Sir James was seen to have preserved his patient's comfort and dignity, at the same time advancing family and societal acceptance of the death of this matriarchal figure. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Martin Helme : Eesti poliitikud annavad Euroopaga liitumisel ära selle, mis pole nende oma / Martin Helme ; interv. Teet Korsten

Index Scriptorium Estoniae

Helme, Martin, 1976-

2003-01-01

Ilmunud ka: Severnoje Poberezhje : Subbota 26. juuli lk. 5. Uurimiskeskuse Vaba Euroopa juht Martin Helme põhjendab oma eurovastaseid seisukohti ja räägib oma tegevusest eurovastaste eesotsas Eestis

How Big Are "Martin's Big Words"? Thinking Big about the Future.

Science.gov (United States)

Gardner, Traci

"Martin's Big Words: The Life of Dr. Martin Luther King, Jr." tells of King's childhood determination to use "big words" through biographical information and quotations. In this lesson, students in grades 3 to 5 explore information on Dr. King to think about his "big" words, then they write about their own…

Riflessioni su diritto e religione a margine del Martin Luther King Day

Directory of Open Access Journals (Sweden)

Giancarlo Anello

2018-04-01

ABSTRACT: April 4, 2018 commemorates the fiftieth anniversary of the death of Martin Luther King jr., in Memphis-Tennessee. The importance of Martin Luther King’s personality goes far beyond the borders of United States and spreads on the global scale. The present paper concerns the universality and the present impact of Martin Luther King’s legacy, considering also the European context. The paper analyses in brief the history of Martin Luther King, taking into account both his activism in the US and his international criticism against global issues such as post-colonialism and third-worldism; a second part is dedicated to the so called religious “global left” of the 50s and 70s. Conclusions show how and why the global religions have still to be considered a critical background for the rule of law, its inequalities and its injustices.

Martinický palác v Praze za vlastnictví Jiřího Bořity z Martinic a jeho následovníka Jaroslava Bořity z Martinic. Architektonická podoba a výzdoba

OpenAIRE

Poláčková, Daniela

2011-01-01

Bachelor thesis "Martinic palace in Prague during the ownership of George Bořita of Martinic and his follower Jaroslav Bořita of Martinic. Its architectural form and decoration" is based on the Martinic palace in the Hradčany square during the ownerships of George Bořita of Martinic and Jaroslav Bořita of Martinic. At the beginning you can find the list of the owners, who owned the palace, during this there appeared important changes not only architectural, but also in decoration. The first c...

SIR - small is safe [in reactor design

International Nuclear Information System (INIS)

Hayns, M.

1989-01-01

A joint USA-UK venture has been initiated to design a small nuclear reactor which offers low capital cost, greater flexibility and a potentially lower environmental impact. Called Safe Integral Reactor (SIR), the lead unit could be built in the United Kingdom Atomic Energy Authority's (UKAEA's) Winfrith site if the design is accepted by the UK Nuclear Installations Inspectorate (NII). This article describes the 320 MWe reactor unit that is the basis of the design being developed. (author)

77 FR 14516 - Alabama Power Company, Martin Dam Hydroelectric Project; Notice of Proposed Revised Restricted...

Science.gov (United States)

2012-03-12

... Power Company, Martin Dam Hydroelectric Project; Notice of Proposed Revised Restricted Service List for... for inclusion in, the National Register of Historic Places at the Martin Dam Hydroelectric Project...)). The Commission's responsibilities pursuant to section 106 for the Martin Dam Hydroelectric Project...

Analysis of data acquired by Shuttle Imaging Radar SIR-A and Landsat Thematic Mapper over Baldwin County, Alabama

Science.gov (United States)

Wu, S.-T.

1985-01-01

Seasonally compatible data collected by SIR-A and by Landsat 4 TM over the lower coastal plain in Alabama were coregistered, forming a SIR-A/TM multichannel data set with 30 m x 30 m pixel size. Spectral signature plots and histogram analysis of the data were used to observe data characteristics. Radar returns from pine forest classes correlated highly with the tree ages, suggesting the potential utility of microwave remote sensing for forest biomass estimation. As compared with the TM-only data set, the use of SIR-A/TM data set improved classification accuracy of the seven land cover types studied. In addition, the SIR-A/TM classified data support previous finding by Engheta and Elachi (1982) that microwave data appear to be correlated with differing bottomland hardwood forest vegetation as associated with varying water regimens (i.e., wet versus dry).

SIRS score on admission and initial concentration of IL-6 as severe acute pancreatitis outcome predictors.

Science.gov (United States)

Gregoric, Pavle; Pavle, Gregoric; Sijacki, Ana; Ana, Sijacki; Stankovic, Sanja; Sanja, Stankovic; Radenkovic, Dejan; Dejan, Radenkovic; Ivancevic, Nenad; Nenad, Ivancevic; Karamarkovic, Aleksandar; Aleksandar, Karamarkovic; Popovic, Nada; Nada, Popovic; Karadzic, Borivoje; Borivoje, Karadzic; Stijak, Lazar; Stefanovic, Branislav; Branislav, Stefanovic; Milosevic, Zoran; Zoran, Milosević; Bajec, Djordje; Djordje, Bajec

2010-01-01

Early recognition of severe form of acute pancreatitis is important because these patients need more agressive diagnostic and therapeutical approach an can develope systemic complications such as: sepsis, coagulopathy, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Dysfunction Syndrome (MODS), Multiple Organ Failure (MOF). To determine role of the combination of Systemic Inflammatory Response Syndrome (SIRS) score and serum Interleukin-6 (IL-6) level on admission as predictor of illness severity and outcome of Severe Acute Pancreatitis (SAP). We evaluated 234 patients with first onset of SAP appears in last twenty four hours. A total of 77 (33%) patients died. SIRS score and serum IL-6 concentration were measured in first hour after admission. In 105 patients with SIRS score 3 and higher, initial measured IL-6 levels were significantly higher than in the group of remaining 129 patients (72 +/- 67 pg/mL, vs 18 +/- 15 pg/mL). All nonsurvivals were in the first group, with SIRS score 3 and 4 and initial IL-6 concentration 113 +/- 27 pg/mL. The values of C-reactive Protein (CRP) measured after 48h, Acute Physiology and Chronic Health Evaluation (APACHE II) score on admission and Ranson score showed the similar correlation, but serum amylase level did not correlate significantly with Ranson score, IL-6 concentration and APACHE II score. The combination of SIRS score on admission and IL-6 serum concentration can be early, predictor of illness severity and outcome in SAP.

Sweeping at the Martin boundary of a fine domain

DEFF Research Database (Denmark)

El Kadiri, Mohamed; Fuglede, Bent

2016-01-01

We study sweeping on a subset of the Riesz-Martin space of a fine domain in R n   (n≥2), both with respect to the natural topology and the minimal-fine topology, and show that the two notions of sweeping are identical.......We study sweeping on a subset of the Riesz-Martin space of a fine domain in R n   (n≥2), both with respect to the natural topology and the minimal-fine topology, and show that the two notions of sweeping are identical....

Martin Winckler.

Science.gov (United States)

Winckler, Martin

2004-03-27

Martin Winckler, born Marc Zaffran in 1955, is a French family doctor, a writer, a translator, and a cultural critic. Since the publication of La Vacation (Paris: POL, 1989), a novel based on his experience in an abortion clinic, he has published more than 20 books (fiction and non-fiction), including a user's manual of contraceptive devices (Contraceptions mode d'emploi. Vauvert: Le Diable Vauvert, 2003). His novel La maladie de Sachs has been translated into English as The Case of Dr Sachs (New York: Seven Stories Press, 2000). Winckler was recently a guest speaker at the Joint Meeting of the American Society of Bioethics and Humanities and the Canadian Society of Bioethics in Montreal, Canada. He will be a guest speaker at the Royal College of General Practitioners' Spring Symposium, in April this year in Bournemouth, UK.

Sociologia e história na obra de José de Souza Martins

Directory of Open Access Journals (Sweden)

William Héctor Gómez Soto

Full Text Available Resumo O autor analisa a sociologia de José de Souza Martins, centrando a atenção em sua perspectiva teórica e seu método dialético. Martins escolhe como objeto aquilo que está à margem da sociedade e das ciências sociais, como, por exemplo, o destino das populações rurais, os sonhos dos trabalhadores das grandes cidades, a aparição do demônio numa fábrica e a vida cotidiana do homem simples. Discípulo de Florestan Fernandes, Martins dialoga com Marx e Lefebvre, dos quais toma duas noções fundamentais: a de menos-valia e a de resíduo. O autor deste artigo destaca que essas duas noções, aparentemente insignificantes, são a chave para compreender a contribuição de Martins. Na sociologia de Martins, o que está à margem e que é liminar não apenas é um tema como também, e principalmente, um recurso metodológico.

Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination.

Directory of Open Access Journals (Sweden)

Alison E Ringel

Full Text Available Sir2 is an NAD(+-dependent histone deacetylase required to mediate transcriptional silencing and suppress rDNA recombination in budding yeast. We previously identified Tdh3, a glyceraldehyde 3-phosphate dehydrogenase (GAPDH, as a high expression suppressor of the lethality caused by Sir2 overexpression in yeast cells. Here we show that Tdh3 interacts with Sir2, localizes to silent chromatin in a Sir2-dependent manner, and promotes normal silencing at the telomere and rDNA. Characterization of specific TDH3 alleles suggests that Tdh3's influence on silencing requires nuclear localization but does not correlate with its catalytic activity. Interestingly, a genetic assay suggests that Tdh3, an NAD(+-binding protein, influences nuclear NAD(+ levels; we speculate that Tdh3 links nuclear Sir2 with NAD(+ from the cytoplasm.

Investigating The Travelling Wave Solution For an SIR Endemic ...

African Journals Online (AJOL)

This paper presents the travelling wave solution for an SIR endemic disease model with no disease related death when the spatial spread of the susceptible is not negligible. In this case the disease is driven by both the susceptible and the infective classes. The population is open since the disease is habitually prevalent in ...

Science and controversy a biography of Sir Norman Lockyer

CERN Document Server

Meadows, A

2008-01-01

Sir Norman Lockyer left Nature, the world''s leading scientific journal, as his lasting memorial. But his life, and controversial theories, are an important part of science history. His ideas were at the forefront of public debate, and ranged from brilliant to perverse. This entertaining book is a fascinating insight into his eventful life

Martin Luther King Jr. contest winning posters to be displayed in downtown Blacksburg

OpenAIRE

Shannon, Kelly Baker

2010-01-01

Each year as part of the Martin Luther King Jr. celebration at Virginia Tech area kindergarten through 12th grade students are invited to participate in the annual Martin Luther King Jr. poster contest.

Buffels (Wes), Elsies, Sir Lowry's pass, Steenbras and Buffels (Oos)

CSIR Research Space (South Africa)

Heinecken, TJE

1982-06-01

Full Text Available This report is a synthesis of all available information on five of the smaller rivers discharging in to False bay combined as a single volume. The rivers dealt with are the Buffels (Wes), Elsies, Sir Lowry' Pass, Steenbras and Buffels (Oos). False...

2016 Martin County QL2 Lidar (FL)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Martin County FL QL2 Lidar Acquisition and Processing Production Task Task Order No. G14PS00574 Woolpert Order No. 76001 Contractor: Woolpert, Inc. This task is for...

Simulation of emotional contagion using modified SIR model: A cellular automaton approach

Science.gov (United States)

Fu, Libi; Song, Weiguo; Lv, Wei; Lo, Siuming

2014-07-01

Emotion plays an important role in the decision-making of individuals in some emergency situations. The contagion of emotion may induce either normal or abnormal consolidated crowd behavior. This paper aims to simulate the dynamics of emotional contagion among crowds by modifying the epidemiological SIR model to a cellular automaton approach. This new cellular automaton model, entitled the “CA-SIRS model”, captures the dynamic process ‘susceptible-infected-recovered-susceptible', which is based on SIRS contagion in epidemiological theory. Moreover, in this new model, the process is integrated with individual movement. The simulation results of this model show that multiple waves and dynamical stability around a mean value will appear during emotion spreading. It was found that the proportion of initial infected individuals had little influence on the final stable proportion of infected population in a given system, and that infection frequency increased with an increase in the average crowd density. Our results further suggest that individual movement accelerates the spread speed of emotion and increases the stable proportion of infected population. Furthermore, decreasing the duration of an infection and the probability of reinfection can markedly reduce the number of infected individuals. It is hoped that this study will be helpful in crowd management and evacuation organization.

Bohuslav Martinů – Werk und Wirkung [...

Czech Academy of Sciences Publication Activity Database

Gabrielová, Jarmila

2009-01-01

Roč. 46, č. 4 (2009), s. 429-431 ISSN 0018-7003 Institutional research plan: CEZ:AV0Z90580513 Keywords : Bohuslav Martinů (1890–1959) * selected music ological events 2009 Subject RIV: AL - Art, Architecture, Cultural Heritage

Breeding season-specific sex diagnostics in the monomorphic House Martin Delichon urbicum

NARCIS (Netherlands)

Piersma, Theunis; Van Der Velde, Marco

Capsule Breeding adult females show a bare brood patch and a smaller cloacal protuberance than males. Aims To examine the degree of sexual dimorphism in various phenotypic traits in House Martins. Methods In the summers of 2005-07 in the northern Netherlands, 160 House Martins were captured. We

Views of Dr. Martin Luther King, Jr.

Science.gov (United States)

Davis, Alan H.

1990-01-01

Discusses views of Martin Luther King, Jr., including concepts of human rights, related counseling approaches, and ethics. Claims King's views provide helpful insights for counselors and clients. Concludes King invited individuals to view challenging life situations as moral opportunities. (Author/ABL)

Joel Martins: Ensaio biográfico sobre um educador

OpenAIRE

Lima, José Antonio

2005-01-01

O objetivo desta pesquisa é coletar e analisar dados referentes à biografia de Joel Martins, demonstrando sua trajetória e importância para a educação. A contribuição de Joel Martins no contexto da educação brasileira, mais especificamente na área de Psicologia da Educação, caracterizou-se por novas perspectivas e abordagens tanto de questões teóricas quanto práticas, por romper com paradigmas, incentivar e promover pesquisas com espírito empreendedor e, acima de tudo, por sua personalidade m...

New Observatory at the University of Tennessee at Martin

Science.gov (United States)

Crews, Lionel J.; Chrysler, R.; Turner, K.

2010-01-01

A new observatory has been completed at the University of Tennessee at Martin and is now open for student research, local teacher training, and public outreach. The telescope is a 16" Meade RCT on a Software Bisque Paramount ME mount, 10' HomeDome, and SBIG CCD camera. The project endured many delays from a necessary change in housing from roll-top roof to dome, to the shutter blowing off in a heavy windstorm. This project was funded primarily by a Tennessee Math-Science Partnership grant (PI: Dr. Michael Gibson, UT Martin) directed at secondary teacher training in sciences.

The 2009 Lindau Nobel Laureate Meeting: Martin Chalfie, Chemistry 2008

OpenAIRE

Chalfie, Martin

2010-01-01

American Biologist Martin Chalfie shared the 2008 Nobel Prize in Chemistry with Roger Tsien and Osamu Shimomura for their discovery and development of the Green Fluorescent Protein (GFP). Martin Chalfie was born in Chicago in 1947 and grew up in Skokie Illinois. Although he had an interest in science from a young age-- learning the names of the planets and reading books about dinosaurs-- his journey to a career in biological science was circuitous. In high school, Chalfie enjoyed his AP Chemi...

Members of the Parliamentary Select Committee on Trade and Industry of the United Kingdom visit the CMS assembly hall.

CERN Multimedia

Patrice Loïez

2002-01-01

Left to right: Austin Ball, Martin O'Neill (Chairman), Richard Burden, Jonathan Djanogly, Lindsay Hoyle, Roger Berry, Linda Perham, Sir Robert Smith, Jackie Lawrence, Michel Della Negra, Tejinder Virdee, Ashok Kumar.

HEALTH COVER, THE CASE OF MARTIN AND CAROLINA IN AUSTRALIA

Directory of Open Access Journals (Sweden)

Maximiliano E KORSTANJE

2014-07-01

Full Text Available This research examines, from a qualitative perspective, some public opinion related to issues associated with the management of a tensed situation. In that process, it identifies some of the subtle differences in the Anglo-Latino cultural expectations. Martin, an Argentine tourist, contracted the Gullien-Barre syndrome in Australia, while enjoying his honeymoon vacation on a Tasmanian island with his partner Carolina. With the passing of days, Martin lost his mobility and was finally hospitalized in emergency. Doctors induced Martin into a coma temporarily because his muscles were paralyzed by the action of the virus. Health costs were more expensive than the family could absorb in Australia. The family had to request the intervention of the Argentine embassy and chancellery for help. In other words, this incident contrasts two world views: hospitality as the institution that historically developed to care and protect travelers versus hospitality as the commercial practice of exploitation.

Le continent noir du désir masculin : Colet et Flaubert, encore

OpenAIRE

Vinken, Barbara

2010-01-01

Il y a peu d’échanges de lettres qui surprennent le lecteur aussi douloureusement que celui entre Louise Colet et Gustave Flaubert. Rarement, l’espoir qui sommeille au fond de tout lecteur d’une histoire d’amour heureux fut à ce point frustré.Les études de Freud – un des plus grands sceptiques en matière d’amour – sur la vie sexuelle éclairent les vicissitudes du désir amoureux masculin. Les Lettres de Flaubert à Colet sont la mise en scène dramatique d’un désir qui suit les complications du ...

Nietzsche, autobiography, history: mourning and Martin and John.

Science.gov (United States)

Champagne, J

1998-01-01

How might gay and lesbian literature be read not as a mimetic representation of homosexuality, but as an activity linked to problems of subjectivity and historiography? Reading Dale Peck's novel Martin and John alongside passages from Friedrich Nietzsche's "On the Uses and Disadvantages of History for Life" and Sigmund Freud's "Mourning and Melancholia," this essay argues for an understanding of Peck's text as an attempt to link two apparently different processes of import to contemporary gay male subjects in particular: the writing of what Nietzsche terms "critical history," and the mourning of those lost to HIV disease. It concludes by linking Martin and John to feminist critiques of identity and traditional historiography, as well as noting the connection between these two critiques.

A new Icimauna Martins & Galileo, 1991, from the Bolivian orocline (Coleoptera, Cerambycidae, Lamiinae, Hemilophini).

Science.gov (United States)

Santos-Silva, Antonio; Perger, Robert

2017-04-07

The Neotropical longhorned beetle tribe Hemilophini has been reviewed by Martins & Galileo (2014a, b) and currently contains 542 species (Monné 2017). Some of the most conspicuous longhorned beetle taxa are found in this tribe, for example species with a pair of cephalic horns (Phoebe Audinet-Serville, 1835), or others that strongly resemble to noxious Lycidae (Coleoptera) (e.g. Apeba Martins & Galileo, 1991, Calocosmus Chevrolat, 1862, or Lycidola Thomson, 1864) (see Lingafelter 2013; Martins & Galileo 2014a, b).

Martin Saar kahe kunstimaailma vahel / Marian Kivila

Index Scriptorium Estoniae

Kivila, Marian, 1985-

2011-01-01

Kunstnik Martin Saare, kelle näitus "Order and Chaos" ("Kord ja kaos") on 31. augustini 2011 avatud galeriis Vaal, loomingust. Samas intervjuus räägib New Yorgis elav kunstnik New Yorgi kunstimaailmast, oma karjäärist, loomingust, kunstieelistustest ja eesmärkidest

BOREAS RSS-15 SIR-C and Landsat TM Biomass and Landcover Maps of the NSA

Science.gov (United States)

Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Ranson, K. Jon

2000-01-01

As part of BOREAS, the RSS-15 team conducted an investigation using SIR-C, X-SAR, and Landsat TM data for estimating total above-ground dry biomass for the SSA and NSA modeling grids and component biomass for the SSA. Relationships of backscatter to total biomass and total biomass to foliage, branch, and bole biomass were used to estimate biomass density across the landscape. The procedure involved image classification with SAR and Landsat TM data and development of simple mapping techniques using combinations of SAR channels. For the SSA, the SIR-C data used were acquired on 06-Oct-1994, and the Landsat TM data used were acquired on 02-Sep-1995. The maps of the NSA were developed from SIR-C data acquired on 13-Apr-1994. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

Quantitative measurement of Y90 brehmmstrahlung images after of Y90 Sir-Spheres implantation to assess lung shunting

International Nuclear Information System (INIS)

Forwood, Nicholas J.; Pocock, Nicholas; Shin, Jane; Young, Andy M; Szeto, Edwin R.

2009-01-01

Full text: Background: In clinical practice the dose of Y 9 0 Sir-Spheres is calculated using a pre injection of Tc 9 9 m MAA. There is however a potential difference due to the different properties of Tc 9 9 m MAA and Y 9 0 Sir-Spheres. We assessed the concordance of lung shunting of Y 9 0 Sir-Spheres estimated using Y 9 0 Bremsstrahlung imaging, compared to shunting assessed using Tc 9 9 m MAA. Methods: 15 Patients were evaluated using 150-200 MBq of Tc 9 9 m MAA injected into the hepatic artery under angiographic guidance. Whole body images were acquired using a LEAP collimator (window of 140 kEv+/-10%). The patients were subsequently treated with Y 9 0 Sir-Spheres. After microspheres injection, whole body brehmsstrahlung images were acquired using a medium energy collimator (window settings of 75 kEv +/- 20%). Tc 9 9 m MAA images were paired with their corresponding bremsstrahlung image and lung shunting in the stu ides calculated simultaneously. Each paired dataset was analyzed by 5 operators. Results: The mean lung shunting for Tc 9 9 m MAA acquisition was 3.32% (SD 2.03) which was significantly lower than the lung shunting using the Y 9 0 acquisitions: mean 16.19% (SD of 6.43). The Pearson coefficient was r = 0.62 (p 9 0 Sir-Spheres bremsstrahlung imaging is higher than that calculated by Tc 9 9 m MAA imaging. The relationship is not sufficiently strong to use bremsstahlung imaging to retrospectively quantify the lung-to-liver shunting as indicated using Tc 9 9 M AA. Further studies are underway to assess the reliability of Tc 9 9 m MAA lung uptake calculations in determining the dose of Y 9 0 Sir-Spheres.

Milestones in plant sulfur research on sulfur-induced-resistance (SIR in Europe

Directory of Open Access Journals (Sweden)

Elke eBloem

2015-01-01

Full Text Available Until the 1970´s of the last century sulfur (S was mainly regarded as a pollutant being the main contributor of acid rain, causing forest dieback in central Europe. When Clean Air Acts came into force at the start of the 1980´s SO2 contaminations in the air were consequently reduced within the next years. S changed from an unwanted pollutant into a lacking plant nutrient in agriculture since agricultural fields were no longer fertilized indirectly by industrial pollution. S deficiency was first noticed in Brassica crops that display an especially high S demand because of its content of S-containing secondary metabolites, the glucosinolates. In Scotland, where S depositions decreased even faster than in continental Europe, an increasing disease incidence with Pyrenopeziza brassicae was observed in oilseed rape in the beginning 1990´s and the concept of sulfur-induced-resistance (SIR was developed after a relationship between the S status and the disease incidence was uncovered. Since then a lot of research was carried out to unravel the background of SIR in the metabolism of agricultural crops and to identify metabolites, enzymes and reactions, which are potentially activated by the S metabolism to combat fungal pathogens. The S status of the crop is affecting many different plant features such as color and scent of flowers, pigments in leaves, metabolite concentrations and the release of gaseous S compounds which are directly influencing the desirability of a crop for a variety of different organisms from microorganisms, over insects and slugs to the point of grazing animals.The present paper is an attempt to sum up the knowledge about the effect of the S nutritional status of agricultural crops on parameters that are directly related to their health status and by this to SIR. Milestones in SIR research are compiled, open questions are addressed and future projections were developed.

Does SOFA predict outcomes better than SIRS in Brazilian ICU patients with suspected infection? A retrospective cohort study

Directory of Open Access Journals (Sweden)

Regis Goulart Rosa

2017-11-01

Full Text Available We compared the discriminatory capacity of the sequential organ failure assessment (SOFA versus the systemic inflammatory response syndrome (SIRS score for predicting ICU mortality, need for and length of mechanical ventilation, ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition and SIRS (SIRS score ≥2 points. From January 2008 to December 2014, 1487 patients were admitted to the ICU due to suspected infection. SOFA ≥2 identified more septic patients than SIRS ≥2 (79.0% [n = 1175] vs. 68.5% [n = 1020], p  7 days (AUROC = 0.65 vs. 0.63, p = 0.004, and length of hospitalization >10 days (AUROC = 0.61 vs. 0.59, p 7 days.

3 CFR 8340 - Proclamation 8340 of January 15, 2009. Martin Luther King, Jr., Federal Holiday, 2009

Science.gov (United States)

2010-01-01

... Proclamation 8340 of January 15, 2009 Proc. 8340 Martin Luther King, Jr., Federal Holiday, 2009By the President of the United States of America A Proclamation On the Martin Luther King, Jr., Federal Holiday, we... Constitution and laws of the United States, do hereby proclaim January 19, 2009, as the Martin Luther King, Jr...

[Sir Geoffrey Keynes 1887-1982. Surgical pioneer, medical historian, humanist].

Science.gov (United States)

Bergljung, Lars

2005-01-01

Sir Geoffrey Keynes (1887 - 1982), was a pioneer in the surgery of breast cancer and thymic deseases, n.b. in patients suffering from myastenia gravis. He strongly disapproved of the longstanding dogma of so called radical mastectomy in breast cancer, and advocated a more limited surgical approach, followed by radiation therapy. This was done more than fifty years before breastconserving surgery has become the therapy of choice and against considerable opposition from the surgical establishment of his days. He also became a pioneer in the surgical treatment of myastenia gravis by thymectomy, at a time when there was no real understanding of the pathophysiology of the disease and when considerable controversy existed as to the importance or non importance of concomitant tumour formation in the thymus. Besides being a busy surgeon Sir Geoffrey was a medical historian, writing the biography of among others William Harvey, a bibliographer with a special interest in the poet and artist William Blake and a bibliophil with a large book collection of great value to medical history.

PALEODRAINAGES OF THE EASTERN SAHARA - THE RADAR RIVERS REVISITED (SIR - A/B IMPLICATIONS FOR A MID - TERTIARY TRANS - AFRICAN DRAINAGE SYSTEM).

Science.gov (United States)

McCauley, John F.; Breed, Carlos S.; Schaber, Gerald G.; McHugh, William P.; Issawi, Bahay; Haynes, C. Vance; Grolier, Maurice J.; El Kilani, Ali

1986-01-01

A complex history of Cenozoic fluvial activity in the presently hyperarid eastern Sahara is inferred from Shuttle Imaging Radar (SIR) data and postflight field investigations in southwest Egypt and northwest Sudan. SIR images were coregistered with Landsat and existing maps as a guide to exploration of the buried paleodrainages (radar rivers) first discovered by SIR-A. Field observations explain the radar responses of three types of radar rivers: RR-1, RR-2, and RR-3. A generalized model of the radar rivers, based on field studies and regional geologic relations, shows apparent changes in river regimen since the large valleys were established during the late Paleogene-early Neogene eras. SIR-based mapping of these paleodrainages, although incomplete, reveals missing links in an area once thought to be devoid of master streams.

Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

Energy Technology Data Exchange (ETDEWEB)

Samat, N. A.; Ma' arof, S. H. Mohd Imam [Department of Mathematics, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjung Malim, Perak (Malaysia)

2014-12-04

This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

International Nuclear Information System (INIS)

Samat, N. A.; Ma'arof, S. H. Mohd Imam

2014-01-01

This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases

Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

Science.gov (United States)

Samat, N. A.; Ma'arof, S. H. Mohd Imam

2014-12-01

This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

Martin L. Perl (1927-2014): A Biographical Memoir

Science.gov (United States)

Feldman, Gary; Jaros, John; Schindler, Rafe H.

2017-10-01

Particle physicist Martin Lewis Perl was recognized worldwide for his discovery of the τ (tau) lepton. For that achievement he received the 1982 Wolf Prize and shared the 1995 Nobel Prize in Physics. He was also a Fellow of the American Physical Society and a member of the National Academy of Sciences (elected 1981). Martin's distinctive approach to scientific investigation had its origins in his upbringing and in the influence of I. I. Rabi, his graduate advisor at Columbia University. After coming to Stanford University in 1963, Martin sought to understand why there should be two and only two families of leptons: the electron and its associated neutrino; and the muon and the muon neutrino. His discovery of the τ provided evidence for a third family of fundamental leptons. The bottom quark was discovered shortly afterward at the Fermi National Accelerator Laboratory, providing evidence for a third family of quarks. Direct evidence for the τ neutrino came later, thereby completing the third lepton generation, while the discovery of the top quark in 1995 completed the third generation of quarks. These achievements established leptons and quarks as fundamental constituents of matter and, along with the fundamental forces, provided the experimental basis of the "Standard Model," our picture of how all matter is made up and how its components interact. Why there are three and only three families of leptons and quarks remains an unsolved mystery to this day.

2016 Martin County QL2 Lidar DEM (FL)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Martin County FL QL2 Lidar Acquisition and Processing Production Task Task Order No. G14PS00574 Woolpert Order No. 76001 Contractor: Woolpert, Inc. This task is for...

Application Of The Bertlmann-Martin Inequalities To Super Symmetric Partners

International Nuclear Information System (INIS)

IGHEZOU, F.Z.; KERRIS, A.T.; MESSAMAH, J.; LOMBARD, R.J.

2011-01-01

The purpose of the present study is to discuss some general aspects of the Bertlmann and Martin inequalities (BMI) in the case of the super symmetric partners. The (BMI) have been established by minoring the multipole sum rules according to a method initiated by Bertlmann and Martin. Application to different potentials and generalizations were derived and tested in various papers. We present new concepts of super symmetry in quantum mechanics (SUSYQM) and apply them to two exactly solvable potentials in the one dimensional space. We apply the (BMI) to their super symmetric partners and we examine the degree of saturation of the (BMI)

Jan Novák, žák Bohuslava Martinů

OpenAIRE

Flašar, Martin

2006-01-01

When comparing the fate of Bohuslav Martinů to that of his pupil Jan Novák, interesting parallels can be found, not only in their work (with which this article does not deal), but also in their lives. Both composers met in 1947 in the U.S.A., and, for half a year, they worked together in New York. Novák’s 1950s compositions were strongly influenced by Martinů’s style. At the same time, both of them suffered the disgrace of the Czechoslovak cultural politics and its executors. Novák venerated ...

[Sir Harold Ridley--the creator of modern cataract surgery].

Science.gov (United States)

Obuchowska, Iwona; Mariak, Zofia

2005-01-01

In February 2000, the worldwide ophthalmology community celebrated the 50th anniversary of one of the twentieth century's most important innovations in eye care--the implantation of the first intraocular lens after cataract extraction by Sir Harold Ridley. It was the initiation of a golden age for the development of ophthalmology, especially cataract surgery. In our paper we would like to remember this outstanding English ophthalmologist and his great invention.

The Philosopher and the Lecturer: John Dewey, Everett Dean Martin, and Reflective Thinking

Science.gov (United States)

Day, Michael; Harbour, Clifford P.

2013-01-01

Adult education scholars have not yet examined the connections between the philosopher, John Dewey, and the lecturer on adult education, Everett Dean Martin. These scholars generally portray Dewey as indifferent to their field. However, Dewey's correspondence with a New York newspaper editor in 1928, recommending Martin's The Meaning of…

Sir Peter Medawar: science, creativity and the popularization of Karl Popper

Science.gov (United States)

Calver, Neil

2013-01-01

Sir Peter Medawar was respected by scientists and literati alike. It was perhaps not surprising, then, that he would choose to involve himself in the ‘two cultures’ debate of 1959 and beyond. The focus of his intervention was the philosophy of Sir Karl Popper. However, Medawar's Popper was not the guru of falsification familiar from philosophy textbooks. Medawar's distinctive interpretation of Popper treated him instead as the source of insights into the role of creativity and imagination in scientific inquiry. This paper traces the context for Medawar's adoption of Popperian philosophy, together with its application before the debate. It then examines, within the context of the debate itself, the way in which Medawar attempted to reconcile scientific inquiry with literary practice. Medawar became increasingly convinced that not only was induction epistemologically unsound, but it was also damaging to the public role of the scientist. His construction of Popperianism would, he envisaged, provide a worthy alternative for scientists’ self-image.

Sir James Paget: Paget's disease of the nipple, Paget's disease of bone.

Science.gov (United States)

Ellis, Harold

2013-04-01

Sir James Paget was one of the 'great' Victorians. Eminent as a surgeon, pathologist and teacher, his nobility of character and application to his work made him a leader in his profession in that age of great men.

Rahaveski nimega olümpia / Martin Hanson

Index Scriptorium Estoniae

Hanson, Martin, 1984-

2008-01-01

Pekingi olümpiamängud toovad Hiinasse 700 miljardi krooni suuruse tuludevoo. 20 miljardit krooni tulu peaks andma ainuüksi olümpiamängude autoritasude ja teleõiguste müük, olümpiakeskuste ehitus ning piletimüük. Vt. samas: Sümbolid raha eest. Kommenteerib Martin Hanson

Vahetusaasta - minu uks maailma / Martin Kuustik ; intervjueerinud Liina Laumets

Index Scriptorium Estoniae

Kuustik, Martin

2011-01-01

Intervjuu rahvusvahelise õpilasvahetuse programmi Youth For Understanding (YFU) kaudu USAs õppinud Martin Kuustikuga, kes peale vahetusaastat on olnud Yfu Eesti aktiivne vabatahtlik ning praegu omandab kõrgharidust samuti USAs

The Influence of Martin Luther King on Education

Science.gov (United States)

Harper, Frederick D.

1973-01-01

In a sense, Martin Luther King was an educator whose students composed citizens of the United States, whose classroom encompassed the entire country, and whose course contents and lesson plans included civil rights, race relations, human rights, and love. (Author)

A Possible Source For Sir Thomas More’s ‘Mountainish Inhumanity’

NARCIS (Netherlands)

Steenbergh, Kristine

2017-01-01

Shakespeare’s authorship of a scene in Sir Thomas More has been established as highly probable on the basis of an analysis of the handwriting, vocabulary, and collocations stylistics. His addition to the play was long believed to have been written soon after publication of the original play, in

Sir Victor Horsley (1857-1916): pioneer of neurological surgery.

Science.gov (United States)

Tan, Tze-Ching; Black, Peter McL

2002-03-01

Immortalized in surgical history for the introduction of "antiseptic wax," Sir Victor Horsley played a pivotal role in shaping the face of standard neurosurgical practice. His contributions include the first laminectomy for spinal neoplasm, the first carotid ligation for cerebral aneurysm, the curved skin flap, the transcranial approach to the pituitary gland, intradural division of the trigeminal nerve root for trigeminal neuralgia, and surface marking of the cerebral cortex. A tireless scientist, he was a significant player in discovering the cure for myxedema, the eradication of rabies from England, and the invention of the Horsley-Clarke stereotactic frame. As a pathologist, Horsley performed research on bacteria and edema and founded the Journal of Pathology. Horsley's kindness, humility, and generous spirit endeared him to patients, colleagues, and students. Born to privilege, he was nonetheless dedicated to improving the lot of the common man and directed his efforts toward the suffrage of women, medical reform, and free health care for the working class. Knighted in 1902 for his many contributions to medicine, Sir Victor met an untimely death during World War I from heat stroke at the age of 59. An iconoclast of keen intellect, unlimited energy, and consummate skill, his life and work justify his epitaph as a "pioneer of neurological surgery."

Sir William Osler's speech at Troy: a Trojan horse?

Science.gov (United States)

Moran, Michael E

2012-01-01

Troy, New York, is a city of 55,000 people in upstate New York located along the Hudson River. A city of surprisingly rich cultural heritage, it was the home of New York state's first hospital outside New York City. The 50th anniversary celebration of Troy's hospital brought William Osler to the city as the keynote speaker. This speech, delivered on November 28, 1900, is one of Sir William's less well known addresses. Osler began his comments with Sir Thomas More's Utopia and talked at length about the hospital, its obligations, the influences it has upon the community, and the role of physicians and surgeons. He broached one of his old saws, the salary of attending physicians and their needed role in hospital management. His words were published in the diamond jubilee's records, but the hospital did not outlive its prominent guest professor, and it closed its doors in 1914. Just like the great historical city of Troy, New York's own Troy was on the brink of decline, and its hospital would be the first fatality. Therefore, it is almost prescient that the words of Osler, taken into historical context juxtaposed against the socioeconomic forces at work, are akin to the Greek's offering of a wooden edifice to end the Trojan War.

The Symmetry between Bruno Latour and Martin Heidegger

DEFF Research Database (Denmark)

Riis, Søren

2008-01-01

In spite of Bruno Latour's explicit critique of Martin Heidegger's conception of technology, he and Heidegger implicitly think very similarly. When looked at carefully, Latour's examination of technical mediation stands out as a detailed reflection of Heidegger's studies. In Pandora's Hope, Latour...

Sir John and Lady Rita Cornforth: a distinguished chemical partnership.

Science.gov (United States)

Purchase, Rupert; Hanson, James R

2015-01-01

This review describes the life of Sir John Cornforth AC CBE FRS, who was awarded the Nobel Prize for Chemistry in 1975. It covers his early life in Australia, his work in Oxford, the National Institute for Medical Research, the Milstead Laboratory of Chemical Enzymology and the University of Sussex, together with the contributions made by his wife, Lady Rita Cornforth.

Stability and bifurcation analysis in a delayed SIR model

International Nuclear Information System (INIS)

Jiang Zhichao; Wei Junjie

2008-01-01

In this paper, a time-delayed SIR model with a nonlinear incidence rate is considered. The existence of Hopf bifurcations at the endemic equilibrium is established by analyzing the distribution of the characteristic values. A explicit algorithm for determining the direction of the Hopf bifurcation and the stability of the bifurcating periodic solutions are derived by using the normal form and the center manifold theory. Numerical simulations to support the analytical conclusions are carried out

The use of multifrequency and polarimetric SIR-C/X-SAR data in geologic studies of Bir Safsaf, Egypt

Science.gov (United States)

Schaber, G.G.; McCauley, J.F.; Breed, C.S.

1997-01-01

Bir Safsaf, within the hyperarid 'core' of the Sahara in the Western Desert of Egypt, was recognized following the SIR-A and SIR-B missions in the 1980s as one of the key localities in northeast Africa, where penetration of dry sand by radar signals delineates previously unknown, sand-buried paleodrainage valleys ('radar-rivers') of middle Tertiary to Quaternary age. The Bir Safsaf area was targeted as a focal point for further research in sand penetration and geologic mapping using the multifrequency and polarimetric SIR-C/X-SAR sensors. Analysis of the SIR-C/X-SAR data from Bir Safsaf provides important new information on the roles of multiple SAR frequency and polarimetry in portraying specific types of geologic units, materials, and structures mostly hidden from view on the ground and on Landsat TM images by a relatively thin, but extensive blanket of blow sand. Basement rock units (granitoids and gneisses) and the fractures associated with them at Bir Safsaf are shown here for the first time to be clearly delineated using C- and L-band SAR images. The detectability of most geologic features is dependent primarily on radar frequency, as shown for wind erosion patterns in bedrock at X-band (3 cm wavelength), and for geologic units and sand and clay-filled fractures in weathered crystal-line basement rocks at C-band (6 cm) and L-band (24 cm). By contrast, Quaternary paleodrainage channels are detectable at all three radar frequencies owing, among other things, to an usually thin cover of blow sand. The SIR-C/X-SAR data investigated to date enable us to make specific recommendations about the utility of certain radar sensor configurations for geologic and paleoenvironmental reconnaissance in desert regions.Analysis of the shuttle imaging radar-C/X-synthetic aperture radar (SIR-C/X-SAR) data from Bir Safsaf provides important new information on the roles of multiple SAR frequency and polarimetry in portraying specific types of geologic units, materials, and

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

DEFF Research Database (Denmark)

Lombard, David B; Alt, Frederick W; Cheng, Hwei-Ling

2007-01-01

Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here, we investigate the localization and function of SIRT3 in vivo. We show that endogenous mouse SIRT3 is a solubl...

76 FR 6841 - Notice of Receipt of Petition for Decision That Nonconforming 2006 and 2007 Aston Martin Vantage...

Science.gov (United States)

2011-02-08

... Martin Vantage Passenger Cars Are Eligible for Importation AGENCY: National Highway Traffic Safety... Martin Vantage passenger cars are eligible for importation. SUMMARY: This document announces receipt by... 2007 Aston Martin Vantage passenger cars that were not originally manufactured to comply with all...

Toward Restoring Some "Punch" in Counselling and Therapy Research and Practice: A Response to Martin.

Science.gov (United States)

Van Hesteren, Frank

1995-01-01

Reacts to Martin's (1995) essay concerning scientism in psychotherapy. Urges placing a moratorium on the "hermeneutic retreat" advocated by Martin, and urges capitalizing on the unique strengths of both positivistic and interpretive modes of inquiry. (JPS)

St. John le calviniste, ou l’émule de Gil-Martin Charlotte Brontë’s Calvinist St. John Emulating James Hogg’s Gil-Martin

Directory of Open Access Journals (Sweden)

Jean Berton

2009-07-01

Full Text Available This article aims to show how far Hogg’s archetypal character, Gil-Martin, influenced Charlotte Brontë’s enigmatic character, St. John, who appears in chapters XXVI to XXXV and is mentioned again in the conclusion of Jane Eyre. Some unexpected words, like “glen”, in a greater Yorkshire area, operate as keywords to a “deep context” study in a neo-contextualist approach. Even though St. John cannot be mistaken for a double of Gil-Martin, a fair number of details tend to prove that James Hogg’s Private Memoirs and Confessions of a Justified Sinner deeply influenced Charlotte Brontë—both pride-driven St. John and Gil-Martin stand for demonic despotism. Yet, if Gil-Martin is a straightforward Gothic illustration of Satan, St. John is a reincarnation of a marble-cold Apollo in a dogma-trapped Calvinist. Brontë’s intention was not so much to denounce noxious excesses in religious beliefs as to set her heroine’s wise independence against nefarious male domination: whereas victimised Robert Wringhim is driven to despair and suicide, self-reliant Jane Eyre escapes from St. John’s grip. In both narratives relationships between men and women are shown as tragically warped by religious behavioural extravagance, but only the female character is granted a positive outcome to serve an optimistic view on life: Robert Wringhim is violently wrung out of the society of men and women, St. John Rivers, from “Marsh End”, blindly drifts away to his death in India, and airy Jane, of “Moor House”, wafts away to anchor to Edward Rochester, the sender of the airwave-born call.

Scorsese uus ametipost / Martin Scorsese ; interv. Kristiina Davidjants

Index Scriptorium Estoniae

Scorsese, Martin

2007-01-01

Martin Scorsese asutas koos teiste režissööridega 1990. aastal filmifondi The Film Foundation, mille eesmärgiks on vanade filmide restaureerimine ja säilitamine. Režissöör rääkis ajakirjanikega 2006. aasta Rooma filmifestivalil

78 FR 38091 - Airworthiness Criteria: Proposed Airship Design Criteria for Lockheed Martin Aeronautics Model...

Science.gov (United States)

2013-06-25

..., 2012 Lockheed Martin Aeronautics submitted an application for type certification for the model LMZ1M..., views, or arguments as they may desire. Commenters should identify the proposed design criteria on the... Lockheed Martin Aeronautics submitted an application for type certification for the model LMZ1M airship...

Sir Rudolf Peierls Selected private and scientific correspondence

CERN Document Server

Lee, Sabine

2007-01-01

This edition of the private and scientific correspondence of Sir Rudolf Peierls gives a unique insight into the life and work of one of the greatest theoretical physicists of the 20th century. Rudolf Peierls' scientific work contributed to the early developments in quantum mechanics, and he is well known and much appreciated for his contributions to various disciplines, including solid state physics, nuclear physics, and particle physics. As an enthusiastic and devoted teacher, he passed on his knowledge and understanding and inspired the work of collaborators and students alike. As an effecti

Application of Homotopy Perturbation and Variational Iteration Methods to SIR Epidemic Model

DEFF Research Database (Denmark)

Ghotbi, Abdoul R.; Barari, Amin; Omidvar, M.

2011-01-01

effective strategy against childhood diseases, the development of the framework that would predict the optimal vaccine coverage level needed to prevent the spread of diseases is crucial. The SIR model is a standard compartmental model that has been used to describe many epidemiological diseases...

Sir Victor Horsley: pioneer craniopharyngioma surgeon.

Science.gov (United States)

Pascual, José M; Prieto, Ruth; Mazzarello, Paolo

2015-07-01

Sir Victor Horsley (1857-1916) is considered to be the pioneer of pituitary surgery. He is known to have performed the first surgical operation on the pituitary gland in 1889, and in 1906 he stated that he had operated on 10 patients with pituitary tumors. He did not publish the details of these procedures nor did he provide evidence of the pathology of the pituitary lesions operated on. Four of the patients underwent surgery at the National Hospital for Neurology and Neurosurgery (Queen Square, London), and the records of those cases were recently retrieved and analyzed by members of the hospital staff. The remaining cases corresponded to private operations whose records were presumably kept in Horsley's personal notebooks, most of which have been lost. In this paper, the authors have investigated the only scientific monograph providing a complete account of the pituitary surgeries that Horsley performed in his private practice, La Patologia Chirurgica dell'Ipofisi (Surgical Pathology of the Hypophysis), written in 1911 by Giovanni Verga, Italian assistant professor of anatomy at the University of Pavia. They have traced the life and work of this little-known physician who contributed to the preservation of Horsley's legacy in pituitary surgery. Within Verga's pituitary treatise, a full transcription of Horsley's notes is provided for 10 pituitary cases, including the patients' clinical symptoms, surgical techniques employed, intraoperative findings, and the outcome of surgery. The descriptions of the topographical and macroscopic features of two of the lesions correspond unmistakably to the features of craniopharyngiomas, one of the squamous-papillary type and one of the adamantinomatous type. The former lesion was found on necropsy after the patient's sudden death following a temporal osteoplastic craniectomy. Surgical removal of the lesion in the latter case, with the assumed nature of an adamantinomatous craniopharyngioma, was successful. According to the

Ühendatud inimeste üksindus / Martin Ehala

Index Scriptorium Estoniae

Ehala, Martin, 1963-

2007-01-01

Vastukaja art.: Sutrop, Margit. Vabadus ja vastutus // Postimees : AK : Arvamus. Kultuur (2007) 20. jaan. Artikli autor Martin Ehala selgitab, miks laguneb lääne ühiskondades sotsiaalne kapital ja kaob ühiskonda liitev meie-tunne. Kolmest olulisest sotsiaalsest nähtusest : individualismist, kollektivismist ja sotsiaalsest kapitalist. Üks olulisemaid tingimusi meie-tunde arenemiseks on ühiste väärtuste olemasolu

Sex allocation in the sexually monomorphic fairy martin

NARCIS (Netherlands)

Magrath, MJL; Green, DJ; Komdeur, J

Offspring sex ratios were examined at the population and family level in the sexually monomorphic, socially monogamous fairy martin Petrochelidon ariel at five colony sites over a 4-year period (1993 1996). The sex of 465 nestlings from 169 broods % as determined using sex-specific PCR at the CHD

A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability.

Directory of Open Access Journals (Sweden)

Tânia Reis

2010-11-01

Full Text Available Obesity has a strong genetic component, but few of the genes that predispose to obesity are known. Genetic screens in invertebrates have the potential to identify genes and pathways that regulate the levels of stored fat, many of which are likely to be conserved in humans. To facilitate such screens, we have developed a simple buoyancy-based screening method for identifying mutant Drosophila larvae with increased levels of stored fat. Using this approach, we have identified 66 genes that when mutated increase organismal fat levels. Among these was a sirtuin family member, Sir2. Sirtuins regulate the storage and metabolism of carbohydrates and lipids by deacetylating key regulatory proteins. However, since mammalian sirtuins function in many tissues in different ways, it has been difficult to define their role in energy homeostasis accurately under normal feeding conditions. We show that knockdown of Sir2 in the larval fat body results in increased fat levels. Moreover, using genetic mosaics, we demonstrate that Sir2 restricts fat accumulation in individual cells of the fat body in a cell-autonomous manner. Consistent with this function, changes in the expression of metabolic enzymes in Sir2 mutants point to a shift away from catabolism. Surprisingly, although Sir2 is typically upregulated under conditions of starvation, Sir2 mutant larvae survive better than wild type under conditions of amino-acid starvation as long as sugars are provided. Our findings point to a Sir2-mediated pathway that activates a catabolic response to amino-acid starvation irrespective of the sugar content of the diet.

78 FR 35630 - Martin Dam Hydroelectric Project; Notice of Availability of the Draft Environmental Impact...

Science.gov (United States)

2013-06-13

... Hydroelectric Project; Notice of Availability of the Draft Environmental Impact Statement for the Martin Dam Hydroelectric Project and Intention To Hold Public Meetings In accordance with the National Environmental Policy... the Martin Dam Hydroelectric Project (FERC No. 349), located on the Tallapoosa River in Tallapoosa...

All in the family: a belated response to Knudson-Martin's feminist revision of Bowen theory.

Science.gov (United States)

Horne, K Blake; Hicks, Mary W

2002-01-01

The first formal attempt at revising Bowen theory within the marriage and family therapy literature is represented in the work of Knudson-Martin (1994). Claiming that several of the theory's concepts are defined at odds with female development, Knudson-Martin (1994) reconceptualizes and expands Bowen theory to rectify these perceived shortcomings. In turn, we address several fundamental concerns with Knudson-Martin's critique and revision of Bowen theory. An alternative representation of Bowen Theory, as well as its relationship to feminist thought, is put forth. Suggestions for the field's future relationship to Bowen theory are also discussed.

Uranium deposits in the Beaverlodge area, northern Saskatchewan: their relationship to the Martin Group (Proterozoic) and the underlying basement

International Nuclear Information System (INIS)

Mazimhaka, P.K.; Hendry, H.E.

1989-01-01

The rocks of the Martin Group crop out in an area 60 km by 50 km north of Lake Athabasca near Uranium City, northern Saskatchewan. This area has numerous uranium showings within a few kilometres of the unconformity below the Martin Group. Mineralization occurs in fault zones, in basement rocks and in sedimentary and volcanic rocks of the Martin Group. Martin Group sediments accumulated in alluvial fans, braided streams, and ephemeral lakes. The thickest sequence (8 km to 10 km) is preserved in the Beaverlodge area, near Uranium City. The style of sedimentation changed through time as the basin evolved from deposition of conglomeratic detritus along fault scarps to the accumulation of silt in ephemeral lakes. The uneven nature of the sub-Martin unconformity surface, the lithotype of the lowermost conglomerates and breccias (Beaverlodge Formation), and the shape of the basin fill indicate deposition in fault-controlled basins. The earliest economic uranium mineralization in the rocks of the Martin Group was epigenetic. The mineralization was coeval with that in basement rocks. Economic mineralization in basement rocks and in the lowermost formation of the Martin Group is close to the unconformity. Epigenetic uranium mineralization thus appears to have resulted from processes that were related, in time and space, to either the formation of the unconformity or the deposition of the Martin Group or both. (author). 29 refs, 5 figs

Betooni ootab ees hiilgav tulevik / Martin Aunin ; intervjueerinud Mari Sarv

Index Scriptorium Estoniae

Aunin, Martin, 1971-

2009-01-01

Arhitekt Martin Aunin betooni kasutamisest enda projekteeritud hoonete juures, betoonist kui väärikast ja paindlikust materjalist, mida saab kasutada kõikjal, betoonelementide kasutamisest, betooni kujundusvõimalustest ja tulevikust

May thrombopoietin be a useful marker of sepsis severity assessment in patients with SIRS entering the emergency department?

Science.gov (United States)

Segre, Elisabetta; Pigozzi, Luca; Lison, Davide; Pivetta, Emanuele; Bosco, Ornella; Vizio, Barbara; Suppo, Umberto; Turvani, Fabrizio; Morello, Fulvio; Battista, Stefania; Moiraghi, Corrado; Montrucchio, Giuseppe; Lupia, Enrico

2014-10-01

Thrombopoietin (TPO), a growth factor primarily involved in regulating thrombopoiesis, has been recently implicated in the pathogenesis of sepsis. TPO levels are, indeed, greatly increased in patients with sepsis compared to control subjects, and correlate with sepsis severity. The aim of this study was to evaluate TPO as predictive biomarker of sepsis and of sepsis severity in patients entering the emergency department (ED) with systemic inflammatory response syndrome (SIRS). This was a prospective observational study. Ours is a sub-study of the 'Need-speed trial', a multi-center observational study involving six Italian centers affiliated to the GREAT Italian Network. TPO was measured by ELISA. We enrolled 13 patients with SIRS (6 with acute pancreatitis, 3 with acute heart failure, 1 with pulmonary embolism, and 3 with allergic reactions), and 40 patients with sepsis, eight of whom had severe sepsis and three septic shock. TPO was significantly higher in patients with sepsis than with SIRS. In addition, TPO was higher in patients with severe sepsis than with sepsis, and in patients with septic shock than with severe sepsis, although these differences did not reach the statistical significance. Our preliminary results suggest that TPO may have the potential to be considered a promising early biomarker for both the diagnosis of sepsis and the assessment of sepsis severity in patients with SIRS entering the ED.

Agro-transformation and evaluation of resistance to Phytophthora infestansin Solanum tuberosumL. variety Désirée

Directory of Open Access Journals (Sweden)

Jeanette Orbegozo

2014-03-01

Full Text Available The Oomycete Phytophthora infestans (Mont. de Bary, the causal agent of the disease known as late blight, is primarily responsible for the decreased in production performance and potato crops worldwide. The integration of the complete Rgenes sequences in the potato genome using Agro-transformation appears an alternative to be considered in the fight against this pathogen. The Rpi-blb2 gene (Rgene from the wild species Solanum bulbocastanumDunal shows a broad resistance to isolates ofP. infestans,making it an important candidate for plant breeding studies. This paper reports the integration of the Rpi-blb2gene into potato var. Désirée genome by Agrobacterium tumefaciens- mediated transformation system, the molecular characterization of 29 events transformed and whole plant infection with isolate POX67 of P. infestansfrom Peru. Désirée events [Rpi-blb2] 4 and Désirée [Rpi-blb2] 30, showed a substantial resistance to P. infestansinfection confirming complete transfer of the Rpi-blb2gene from a wild species to a cultivated species by genetic transformation.

All in the Family: A Belated Response to Knudson-Martin's Feminist Revision of Bowen Theory

Science.gov (United States)

Horne, K. Blake; Hicks, Mary W.

2002-01-01

The first formal attempt at revising Bowen theory within the marriage and family therapy literature is represented in the work of Knudson-Martin (1994). Claiming that several of the theory's concepts are defined at odds with female development, Knudson-Martin (1994) reconceptualizes and expands Bowen theory to rectify these perceived shortcomings.…

Udenomssnak: Sådan gør Martin Henriksen

DEFF Research Database (Denmark)

Gabrielsen, Jonas

2011-01-01

EU-kommissionens formand José Manuel Barroso forslog i går onsdag, at EU-landene skal hjælpes med at behandle de mange asylansøgninger fra nordafrikanske flygtninge. Det forslag debatterede Martin Henriksen (DF) i Deadline 17 aftenen før – men ikke uden først at omdefinere debatten fra fælles...

Reflections on experimental science Martin Perl

CERN Document Server

Perl, Martin Lewis

1996-01-01

This is a collection of important lecture and original articles and commentaries by Martin Perl, discoverer of the tau lepton and the third generation of elementary particles, and this year's Nobel Prize winner. This book contains a fascinating and realistic picture of experimental science based on the high energy physics research work carried out by him. Using reprints of his articles with his commentaries, the author presents the various aspects of experimental research in science: the pleasures and risks of experimental work; the pain and frustration with experiments that are useless or fai

Sir William Mitchell (1925-2002)

CERN Multimedia

2002-01-01

Sir William (Bill) Mitchell, former President of the CERN Council, died on 30th October 2002 at the age of 77. Mitchell was professor of Physics at Oxford University from 1978 to 1989, having previously been Professor of Physics, Dean of Science and Deputy Vice-Chancellor at Reading University. From 1985 to 1990 he was Chairman of the UK's Science and Engineering Research Council (SERC), which at the time was the funding agency for the UK's participation in the CERN programme. As Chairman, Mitchell was one of the UK representatives on the CERN Council, and in 1991 he was elected President, a position he held for three years. This was a difficult period for CERN. Financial problems were being faced in many member states, notably in Germany as a result of unification. This led to calls for reductions in the CERN budget and, more significantly, to requests for delays in consderation of future programmes. On the other hand for the future of CERN and the progress of elementary particle physics, it was necessary...

Modern methods in structural geology and tectonics : a series of articles in honour of Martin Burkhard (1957-2006)

OpenAIRE

Schmid, Stefan M.; Mancktelow, Neil; Mosar, Jon; Pfiffner, O. Adrian; Schaer, Jean-Paul

2008-01-01

We briefly report on the conference held in May 2007 in honour of Martin Burkhard in Neuchâtel. We also present a short account of the achievements of this prominent scientist and teacher by selectively citing some of his workand briefly introduce the series of articles presented here, which represent a tribute to Martin Burkhard. We also add a complete list of publications by Martin Burkhard and co-workers.

The optimal dynamic immunization under a controlled heterogeneous node-based SIRS model

Science.gov (United States)

Yang, Lu-Xing; Draief, Moez; Yang, Xiaofan

2016-05-01

Dynamic immunizations, under which the state of the propagation network of electronic viruses can be changed by adjusting the control measures, are regarded as an alternative to static immunizations. This paper addresses the optimal dynamical immunization under the widely accepted SIRS assumption. First, based on a controlled heterogeneous node-based SIRS model, an optimal control problem capturing the optimal dynamical immunization is formulated. Second, the existence of an optimal dynamical immunization scheme is shown, and the corresponding optimality system is derived. Next, some numerical examples are given to show that an optimal immunization strategy can be worked out by numerically solving the optimality system, from which it is found that the network topology has a complex impact on the optimal immunization strategy. Finally, the difference between a payoff and the minimum payoff is estimated in terms of the deviation of the corresponding immunization strategy from the optimal immunization strategy. The proposed optimal immunization scheme is justified, because it can achieve a low level of infections at a low cost.

An SIRS model with a nonlinear incidence rate

International Nuclear Information System (INIS)

Jin Yu; Wang, Wendi; Xiao Shiwu

2007-01-01

The global dynamics of an SIRS model with a nonlinear incidence rate is investigated. We establish a threshold for a disease to be extinct or endemic, analyze the existence and asymptotic stability of equilibria, and verify the existence of bistable states, i.e., a stable disease free equilibrium and a stable endemic equilibrium or a stable limit cycle. In particular, we find that the model admits stability switches as a parameter changes. We also investigate the backward bifurcation, the Hopf bifurcation and Bogdanov-Takens bifurcation and obtain the Hopf bifurcation criteria and Bogdanov-Takens bifurcation curves, which are important for making strategies for controlling a disease

Motivácia zamestnancov v podniku Schwer Fittings, s.r.o., Martin

OpenAIRE

Badová, Andrea

2014-01-01

Badová, A., Employee motivation in the company Schwer Fittings, s.r.o., Martin. Bachelor thesis. Brno: Mendel University in Brno, 2013. This bachelor thesis is focused on employee motivation in Schwer Fittings, s.r.o., Martin. Main goal of this thesis is to evaluate current state of motivation system in this company and to suggest recommendations that can contribute to increase in employee motivation and to overall satisfaction. The theoretical part is based on literature mentioned in my work...

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.

Science.gov (United States)

Ondracek, Caitlin R; Frappier, Vincent; Ringel, Alison E; Wolberger, Cynthia; Guarente, Leonard

2017-03-07

Sirtuin enzymes depend on NAD + to catalyze protein deacetylation. Therefore, the lowering of NAD + during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic screen to identify two mutations in the catalytic domain of yeast Sir2 that allow the enzyme to function in an NAD + -depleted environment. These mutant enzymes give rise to a significant increase of yeast replicative lifespan and increase deacetylation by the Sir2 ortholog, SIRT1, in mammalian cells. Our data suggest that these mutations increase the stability of the conserved catalytic sirtuin domain, thereby increasing the catalytic efficiency of the mutant enzymes. Our approach to identifying sirtuin mutants that permit function in NAD + -limited environments may inform the design of small molecules that can maintain sirtuin activity in aging organisms. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

The Bertlmann-Martin Inequality and Spin Degrees of Freedom

International Nuclear Information System (INIS)

Boufas, S.; Ighezou, F.-Z.; Lombard, R. J.

2012-01-01

The Bertlmann-Martin inequality based on the dipole sum rule is revisited taking into account the spin degrees of freedom. We consider 1 and 2 particles of spin 1/2 in a mean field, adding a spin dependent interaction. The derivation of the inequality relies on the closure relation. We discuss the effect of the Pauli principle, and the restrictions it imposes on the use of the closure relation. The problem is exemplified by a simple model based on harmonic forces. Moreover, in the 2 particle case, the model we use is separable in the relative and centre of mass coordinates. In this case, we show that for operators connecting only singlet states, their sum rule can be calculated in the usual way, i. e. via the double commutator of this operator with the Hamiltonian. An upper bound can also be obtained by using the Bertlmann-Martin technique. This is not possible for operators involving a transition between singlet and triplet states. (author)

Wilson Martins: between the intelligentsia and the university (1951

Directory of Open Access Journals (Sweden)

Névio de Campos

2012-05-01

Full Text Available Abstract The purpose of this article is to analyze the presence of Ortega y Gasset in the Parana’s State group during the 1950s, especially his influence in the thinking of Wilson Martins, and to emphasize the debate on the ideas of the intellectual and the university. The article discusses about the contributions of this Parana’s thinker on the Parana’s university teaching constituting and organizing process, and emphasizes that the Wilson Martins’ role consisted in promoting the debate on the presence of the intellectual person in modern society, attributing the mission as guardian of the moral and herald of cultural renovation, without forgetting the Brazilian and European political-cultural context as the founding background to higher education. It bases itself on the speech entitled “The rebellion against intelligence and the mission of the university”, that occurred at the University of Parana in 1951, and on the work The History of Brazilian Intelligence, written by Wilson Martins.

Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination

OpenAIRE

Miao, Anqi; Zhang, Jian; Zhang, Tongqian; Pradeep, B. G. Sampath Aruna

2017-01-01

A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control.

Bora Bora, Tahaa, and Raiatea, French Polynesia, Landsat and SIR-C Images Compared to SRTM Shaded

Science.gov (United States)

2005-01-01

Bora Bora, Tahaa, and Raiatea (top to bottom) are Polynesian Islands about 220 kilometers (135 miles) west-northwest of Tahiti in the South Pacific. Each of the islands is surrounded by a coral reef and its associated islets ('motus') that enclose a lagoon. Actually, as seen here, Tahaa and Raiatea are close enough together to share a common lagoon and reef. These islands are volcanic in origin and were built up from the sea floor by lava extrusions millions of years ago. None is now active, and all are deeply eroded. This display compares three differing 'views from space' of these islands. On the left, an image from the Landsat 7 satellite shows the islands as they might have appeared to an astronaut in orbit in 1999 (but a little sharper and with atmospheric haze suppressed). In the middle is an image created from data gathered by the third-generation Shuttle Imaging Radar (SIR-C), flown in 1994. On the right is a graphic illustrating elevation data gathered by the Shuttle Radar Topography Mission (SRTM) in 2000. Each of these images shows very different information as compared to the other two. Landsat sees clouds, which are almost always above these islands, blocking the view of the terrain. It also readily sees through shallow water down to the reefs. SIR-C sees the waves and other effects of winds upon the ocean surface. It does not look through water to see the reefs, but it clearly separates land and water. It also provides a bolder (but distorted) view of the islands' topographic patterns. With the ability of radar to see through clouds and provision of its own illumination, the SIR-C view is not limited by clouds nor their shadows. SRTM was designed to provide new information that is missing in the Landsat and SIR-C views. Specifically, SRTM created the world's first near-global, detailed elevation model. Natural topographic shading in Landsat imagery and radar topographic shadowing of SIR-C give some evidence of the shape of the ground but do not

Martin Luther in Primetime. Television Fiction and Cultural Memory Construction in Cold War Germany

Directory of Open Access Journals (Sweden)

Stewart Anderson

2013-06-01

Full Text Available In 1983, both East and West Germany celebrated Martin Luther’s 500th birthday with great fanfare.  Nowhere was this competition more provocative and visually arresting, however, than in two multi-part television plays which depicted Luther’s life: the West German Martin Luther, broadcast by the public station ZDF in April, and the East German title of the same name, aired in October.  In this essay, I argue that the East German version constituted an appropriative strategy of memory formation – one which depicted Luther’s positive qualities and grafted them into the Marxist canon of heroes.  In contrast, the ZDF Martin Luther, which featured a highly rational Luther, projected what Jan Assmann has termed a normative strategy of harnessing Luther’s memory, focusing on Luther’s intellectual arguments and anti-radicalism.

Patterns of Gram-stained fecal flora as a quick diagnostic marker in patients with severe SIRS.

Science.gov (United States)

Shimizu, Kentaro; Ogura, Hiroshi; Tomono, Kazunori; Tasaki, Osamu; Asahara, Takashi; Nomoto, Koji; Morotomi, Masami; Matsushima, Asako; Nakahori, Yasutaka; Yamano, Shuhei; Osuka, Akinori; Kuwagata, Yasuyuki; Sugimoto, Hisashi

2011-06-01

The gut is an important target organ of injury during critically ill conditions. Although Gram staining is a common and quick method for identifying bacteria, its clinical application has not been fully evaluated in critically ill conditions. This study's aims were to identify patterns of Gram-stained fecal flora and compare them to cultured bacterial counts and to investigate the association between the patterns and septic complications in patients with severe systemic inflammatory response syndrome (SIRS). Fifty-two patients with SIRS were included whose Gram-stained fecal flora was classified into three patterns. In a diverse pattern, large numbers of multiple kinds of bacteria completely covered the field. In a single pattern, one specific kind of bacteria or fungi predominantly covered the field. In a depleted pattern, most bacteria were diminished in the field. In the analysis of fecal flora, the numbers of total obligate anaerobes in the depleted pattern was significantly lower than those in the diverse pattern and single pattern (p Gram-stained fecal flora can be classified into three patterns and are associated with both cultured bacterial counts and clinical information. Gram-stained fecal bacteria can be used as a quick bedside diagnostic marker for severe SIRS patients.

75 FR 62531 - Alabama Power Company; Project No. 349-150-Alabama Martin Dam Hydroelectric Project; Notice of...

Science.gov (United States)

2010-10-12

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Alabama Power Company; Project No. 349-150--Alabama Martin Dam Hydroelectric Project; Notice of Proposed Restricted Service List for a... the Martin Dam Hydroelectric Project. The Programmatic Agreement, when executed by the Commission, the...

Désir, besoin, dépendance : l'addiction comme (épreuve de la modernité

Directory of Open Access Journals (Sweden)

Rita Di Lorenzo

2016-04-01

Full Text Available La frontière entre la santé et la pathologie est un lieu fascinant et dangereux, au caractère poreux et riche de familiarités des deux côtés, inavouées et coûteuses. Le terme d’addiction semble s’installer précisément sur cette frontière, gagnant en étendue médiatique ce qu’il perd en précision nosographique ; ainsi, aujourd’hui, nous serions « tous addicts » – au sucre, au téléphone portable, au chocolat, au café, aux soldes, à la chirurgie esthétique, à Facebook, à l’amour, cette liste pouvant être continuée par chacun d’entre nous puisque nous avons tous fait, nous faisons et ferons tous, l’expérience de la force des (mauvaises habitudes, du désir, voire de la pulsion, de l’abus et de la dépendance. Notre société contemporaine semble stimuler cette expérience, en multipliant tant les objets addictogènes que les comportements addictifs : d’une part par le statut attribué aux biens sériels, d’autre part par la dimension pulsionnelle revendiquée dans les habitudes de consommation. Société du plaisir, peut-être plus hédoniste qu’épicurienne, l’époque contemporaine impose le plaisir et son désir comme nouvelle norme. Dès lors, quel est notre rapport à la pulsion, au désir compulsif, au dépassement des limites imposées aux besoins et aux envies socialement acceptables ? Comment notre société régule le désir ? Comment la politique et les médias concourent-ils à le structurer, voire à le prescrire ? Quels mécanismes à l’œuvre dans l’addiction contredisent cette prescription, et surtout : s’agit-il véritablement d’une contradiction ? Notre culture de performance et satisfaction rapides peut effectivement expliquer certaines dépendances induites par leur objet ; néanmoins, la véritable addiction mentale se nourrit d’éléments plus profondément constitutifs de l’identité de l’homme moderne et contemporain : avant tout, la fragilité des acquis, la

Vaccination strategies for SIR vector-transmitted diseases.

Science.gov (United States)

Cruz-Pacheco, Gustavo; Esteva, Lourdes; Vargas, Cristobal

2014-08-01

Vector-borne diseases are one of the major public health problems in the world with the fastest spreading rate. Control measures have been focused on vector control, with poor results in most cases. Vaccines should help to reduce the diseases incidence, but vaccination strategies should also be defined. In this work, we propose a vector-transmitted SIR disease model with age-structured population subject to a vaccination program. We find an expression for the age-dependent basic reproductive number R(0), and we show that the disease-free equilibrium is locally stable for R(0) ≤ 1, and a unique endemic equilibrium exists for R(0) > 1. We apply the theoretical results to public data to evaluate vaccination strategies, immunization levels, and optimal age of vaccination for dengue disease.

Impulsive vaccination and dispersal on dynamics of an SIR epidemic model with restricting infected individuals boarding transports

Science.gov (United States)

Jiao, Jianjun; Cai, Shaohong; Li, Limei

2016-05-01

To understand the effect of impulsive vaccination and restricting infected individuals boarding transports on disease spread, we establish an SIR model with impulsive vaccination, impulsive dispersal and restricting infected individuals boarding transports. This SIR epidemic model for two regions, which are connected by transportation of non-infected individuals, portrays the evolvement of diseases. We prove that all solutions of the investigated system are uniformly ultimately bounded. We also prove that there exists globally asymptotically stable infection-free boundary periodic solution. The condition for permanence is discussed. It is concluded that the approach of impulsive vaccination and restricting infected individuals boarding transports provides reliable tactic basis for preventing disease spread.

Martin Van Butchell (1735-1814): the eccentric, "kook" dentist of old London.

Science.gov (United States)

Christen, A G; Christen, J A

1999-11-01

This article is a thumbnail sketch of the life and times of Martin Van Butchell (1735-1814), an eccentric, "kook" advertising dentist of Old London. Van Butchell earned these descriptive labels by displaying an unorthodox lifestyle, an outrageous personal appearance and outlandish, extreme and socially unacceptable personal and professional behaviors. While the general populace seemed to be fascinated by his strange ways, dentists and physicians were generally alienated by them. Nevertheless, he was considered a good dentist for his time, and he was extremely popular with his patients. Martin practiced dentistry for 23 years, and he practiced medicine as well, specializing in the treatment of ruptures and anal fistulas. Van Butchell interacted greatly with both John and William Hunter, who became two of the most famous and talented physicians, surgeons, anatomists and biologists of all time. When his first wife, Mary died, Martin arranged for her body to be embalmed and publicly displayed in his dental office for advertising purposes. Her preserved body was shown at the Museum of the Royal College of Surgeons (London), until it was destroyed by a German fire bomb in May, 1941. Mary's remains were on public display for a total of 166 years.

Näidendivõistlusel triumfeeris taas kord Martin Algus / Kaarel Kressa

Index Scriptorium Estoniae

Kressa, Kaarel, 1983-

2009-01-01

Eesti Teatri Agentuuri näidendivõistlusel sai esikoha Martin Algus näidendiga "Postmodernsed leibkonnad", teise koha Siim Nurliku kirjatükk "Kas ma olen nüüd elus" ja kolmanda koha Loone Otsa töö "Libuhunt"

Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination

Directory of Open Access Journals (Sweden)

Anqi Miao

2017-01-01

Full Text Available A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control.

Identifying settlements on the SIR-B images of Rimbobujang and the surrounding areas, Sumatra, Indonesia

Directory of Open Access Journals (Sweden)

Sutanto .

2013-07-01

SIR-B image proves to be a reasonably good tool to identify rural settlement in an open area, especially for that with high density of houses. Its use to identify towns and cities is more recommended.

Martin Marietta Energy Systems Nuclear Criticality Safety Improvement Program

International Nuclear Information System (INIS)

Speas, I.G.

1987-01-01

This report addresses questions raised by criticality safety violation at several DOE plants. Two charts are included that define the severity and reporting requirements for the six levels of accidents. A summary is given of all reported criticality incident at the DOE plants involved. The report concludes with Martin Marietta's Nuclear Criticality Safety Policy Statement

SIR-A views our environment An Experiment in the Batu Angkal Area, West Kalimantan, Indonesia

Directory of Open Access Journals (Sweden)

Sutanto .

2013-07-01

Factors affecting the ease of identification are. mainly tonal contrast, shape, size, surface roughness, direction in relation to the illumination, and dielectric constant. Due to the future availability of SIR-B image of Kalimantan, further study is recommended.

[Sir Francis Galton: the father of eugenics].

Science.gov (United States)

Aubert-Marson, Dominique

2009-01-01

Not only was Sir Francis Galton a famous geographer and statistician, he also invented "eugenics" in 1883. Eugenics, defined as the science of improving racial stock, was developed from a new heredity theory, conceived by Galton himself, and from the evolution theory of Charles Darwin, transposed to human society by Herbert Spencer. Galton's eugenics was a program to artificially produce a better human race through regulating marriage and thus procreation. Galton put particular emphasis on "positive eugenics", aimed at encouraging the physically and mentally superior members of the population to choose partners with similar traits. In 1904, he presented his ideas in front of a vast audience of physicians and scientists in London. His widely-publicized lecture served as the starting point for the development of eugenics groups in Europe and the United States during the first half of the 20th century.

Influence of heat conductivity on the performance of RTV SIR coatings with different fillers

Energy Technology Data Exchange (ETDEWEB)

Siderakis, K [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, GR-26110 Patras (Greece); Agoris, D [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, Greece, GR-26500, Rion, Greece (Greece); Gubanski, S [High Voltage Laboratory, Department of Electric Power Engineering, Chalmers University of Technology, S-41296, Gothenburg (Sweden)

2005-10-07

Room temperature vulcanized silicone rubber (RTV SIR) coatings are employed in order to improve the pollution performance of high voltage ceramic insulators by imparting surface hydrophobicity. In this paper, the performance of three RTV SIR coatings containing different fillers is investigated in a salt-fog test. Alumina trihydrate (ATH) and silica are the fillers included in the formulation, aiming to increase the material endurance to the energy supplied by the surface electrical activity during periods of hydrophobicity loss. The primary action of these fillers is to increase the material heat conductivity, i.e. the amount of energy conducted to the substrate. In addition, in the case of ATH relief is also achieved due to particle decomposition. The results indicate that for the compositions commercially available, where low amounts of fillers are used, and under the conditions of the test, ATH filled coatings performed better than the silica filled ones. This is attributed to ATH decomposition which further relieves the material structure and therefore decelerates material aging.

Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging.

Science.gov (United States)

Orlandi, Ivan; Pellegrino Coppola, Damiano; Strippoli, Maurizio; Ronzulli, Rossella; Vai, Marina

2017-01-01

Nicotinamide (NAM), a form of vitamin B 3 , is a byproduct and noncompetitive inhibitor of the deacetylation reaction catalyzed by Sirtuins. These represent a family of evolutionarily conserved NAD + -dependent deacetylases that are well-known critical regulators of metabolism and aging and whose founding member is Sir2 of Saccharomyces cerevisiae. Here, we investigated the effects of NAM supplementation in the context of yeast chronological aging, the established model for studying aging of postmitotic quiescent mammalian cells. Our data show that NAM supplementation at the diauxic shift results in a phenocopy of chronologically aging sir2Δ cells. In fact, NAM-supplemented cells display the same chronological lifespan extension both in expired medium and extreme Calorie Restriction. Furthermore, NAM allows the cells to push their metabolism toward the same outcomes of sir2Δ cells by elevating the level of the acetylated Pck1. Both these cells have the same metabolic changes that concern not only anabolic pathways such as an increased gluconeogenesis but also respiratory activity in terms both of respiratory rate and state of respiration. In particular, they have a higher respiratory reserve capacity and a lower non-phosphorylating respiration that in concert with a low burden of superoxide anions can affect positively chronological aging. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Global analysis of multi-strains SIS, SIR and MSIR epidemic models

OpenAIRE

Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier

2014-01-01

International audience; We consider SIS, SIR and MSIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maxim...

Competitive exclusion principle for SIS and SIR models with n strains

OpenAIRE

Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier

2012-01-01

We consider SIS and SIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maximum of each individual basic re...

Montaigne, Sir Ralph Bankes and other English readers of the Essais.

OpenAIRE

O'Brien, John

2013-01-01

This article deals with a hitherto unknown and unpublished early modern English manuscript account of Montaigne's Essais by Sir Ralph Bankes (1631?–77) of Kingston Lacy in Dorset. Bankes's account covers a range of features in Montaigne's work: crucial elements of self-portraiture such as judgement, but also his attitude to women and doctors. These characteristics are analysed and compared first with Montaigne's own pronouncements about the aspects Bankes selects and secondly with two other s...

SIR (Safe Integral Reactor) - reducing size can reduce cost

International Nuclear Information System (INIS)

Hayns, M.R.

1991-01-01

Traditional engineering economics have favoured the advantages of larger size as a means of reducing specific capital costs and hence unit generating costs. For large and small plants utilising the same concept, e.g. a small four-loop PWR vs a large four-loop PWR with the same number of components, economies of scale are well established. If, however, a smaller plant is sized to take advantage of features which are only feasible at smaller outputs, is of simpler design, with the advantage taken of the simplified design to produce the most cost-effective layout, and incorporates fewer, more easily replaceable components with minimal assembly on site, it is possible to produce a plant which is competitive with larger plant of more traditional design. When 'system' effects, such as better matching of installed capacity to the growth in demand and the fact that a smaller total capacity will be needed to meet a given demand with a specified level of confidence, are taken into account, it can be shown that a utility's overall cash-flow position can be improved with lower associated absolute financial risks. The UK/US Safe Integral Reactor (SIR) is an integral pressurized water reactor in the 300-400 MW(e) range which utilises conventional water reactor technology in a way not feasible at the very large, sizes of recent years. The SIR concept is briefly explained and its technical and economic advantages in terms of simplicity, construction, maintenance, availability, decommissioning, safety and siting described. The results of system analyses which demonstrate the overall financial advantages to a utility are presented. (author)

Martin Szekely : ne plus dessiner

OpenAIRE

Mokhtari, Sylvie

2012-01-01

Ce livret, publié à l’issue d’une exposition éponyme au Centre Pompidou en 2011-12, présente, sous la conduite de Françoise Guichon les « recherches » et les « projets industriels » du designer qui en 1996 avait déclaré « ne plus dessiner ». Un texte de Philippe-Alain Michaud explicite en deuxième partie de l’opuscule la rencontre de Martin Szekely avec l’artiste Mark Lewis qui réalisa un film à partir du miroir Soleil noir (2007) installé dans les salles de peinture hollandaise de la Nationa...

Procalcitonin, C-reactive protein and serum lactate dehydrogenase in the diagnosis of bacterial sepsis, SIRS and systemic candidiasis.

Science.gov (United States)

Miglietta, Fabio; Faneschi, Maria Letizia; Lobreglio, Giambattista; Palumbo, Claudio; Rizzo, Adriana; Cucurachi, Marco; Portaccio, Gerolamo; Guerra, Francesco; Pizzolante, Maria

2015-09-01

The aim of this study was to evaluate procalcitonin (PCT), C-reactive protein (CRP), platelet count (PLT) and serum lactate dehydrogenase (LDH) as early markers for diagnosis of SIRS, bacterial sepsis and systemic candidiasis in intensive care unit (ICU) patients. Based on blood culture results, the patients were divided into a sepsis group (70 patients), a SIRS group (42 patients) and a systemic candidiasis group (33 patients). PCT, CRP, LDH and PLT levels were measured on day 0 and on day 2 from the sepsis symptom onset. PCT levels were higher in Gram negative sepsis than those in Gram positive sepsis, although the P value between the two subgroups is not significant (P=0.095). Bacterial sepsis group had higher PCT and CRP levels compared with the systemic candidiasis group, whereas PLT and LDH levels showed similar levels in these two subgroups. The AUC for PCT (AUC: 0.892, P candidiasis groups (P=0.093 N.S.). In conclusion, PCT can be used as a preliminary marker in the event of clinical suspicion of systemic candidiasis; however, low PCT levels (candidiasis and SIRS groups.

Sir Ronald A. Fisher and the International Biometric Society.

Science.gov (United States)

Billard, Lynne

2014-06-01

The year 2012 marks the 50th anniversary of the death of Sir Ronald A. Fisher, one of the two Fathers of Statistics and a Founder of the International Biometric Society (the "Society"). To celebrate the extraordinary genius of Fisher and the far-sighted vision of Fisher and Chester Bliss in organizing and promoting the formation of the Society, this article looks at the origins and growth of the Society, some of the key players and events, and especially the roles played by Fisher himself as the First President. A fresh look at Fisher, the man rather than the scientific genius is also presented. © 2014, The International Biometric Society.

Recent advancements in robotic micro-optical assembly at the Lockheed Martin Optical Payload Center of Excellence

Science.gov (United States)

Hwang, David; Larson, Thomas M.

2017-08-01

Lockheed Martin Space Systems Company Optical Payloads Center of Excellence is in process of standing up the Robotic Optical Assembly System (ROAS) capability at Lockheed Martin Coherent Technologies in Colorado. This currently implemented Robotic Optical Assembly has enabled Lockheed Martin to create world-leading, ultra-lowSWAP photonic devices using a closed-loop control robot to precisely position and align micro-optics with a potential fill factor of >25 optics per square inch. This paper will discuss the anticipated applications and optical capability when ROAS is fully operational, as well as challenge the audience to update their "rules of thumb" and best practices when designing low-SWAP optical-mechanical systems that take advantage of Lockheed Martin's ROAS capability. This paper will reveal demonstrated optical pointing and stability performance achievable with ROAS and why we believe these optical specifications are relevant for the majority of anticipated applications. After a high level overview of the ROAS current state, this paper will focus in on recent results of the "Reworkable Micro-Optics Mounting IRAD". Results from this IRAD will correlate to the anticipated optical specifications required for relevant applications.

Investigating Environmentally Sustainable Transport Based on DALY weights and SIR Method

Directory of Open Access Journals (Sweden)

Hossein Nezamianpour Jahromi

2012-09-01

Full Text Available Accessibility is one of the main causes of well-being and growth in contemporary societies. Transportation is the backbone of accessibility systems that lead to the growth of economic and social networks and spatial dispersion of activities. Unfortunately, the adverse effects of transportation have a great impact on the natural and human environment. Since transportation is associated with fossil fuel combustion, it results in emissions of pollutants that cause damage to human health. To save the global eco-system, sustainable development has become an international priority. To deal with the sustainability of transportation systems is an important issue as testified by a growing number of initiatives framed to define and measure sustainability in transportation planning and infrastructure planning as well. The capability of environmental assessment as a sustainability instrument is well known. This study proposes a new approach to rank countries based on environmental sustainability development applying disability adjusted life year (DALY weights for transportation sector emissions. DALY weights consider actual impacts of pollutants on human health. By employing SIR method, a superiority and inferiority ranking method is presented for multiple criteria decision making, the sustainability ranking of a number of European countries is presented. Three various ranking methods extracted from SIR ranking method are discussed and the results and the correlation among them are demonstrated.

Dynamic Behavior for an SIRS Model with Nonlinear Incidence Rate and Treatment

Directory of Open Access Journals (Sweden)

Junhong Li

2013-01-01

Full Text Available This paper considers an SIRS model with nonlinear incidence rate and treatment. It is assumed that susceptible and infectious individuals have constant immigration rates. We investigate the existence of equilibrium and prove the global asymptotical stable results of the endemic equilibrium. We then obtained that the model undergoes a Hopf bifurcation and existences a limit cycle. Some numerical simulations are given to illustrate the analytical results.

Types of Cenozoic Mollusca from Java in the Martin Collection of Naturalis

NARCIS (Netherlands)

Leloux, J.; Wesselingh, F.P.

2009-01-01

An updated type catalogue of the Martin Collection (fossil Mollusca, predominantly from the Cenozoic of Java, Indonesia) is presented. Type specimen data, updated locality data, and illustrations are given.

75 FR 3839 - Martin Luther King, Jr., Federal Holiday, 2010

Science.gov (United States)

2010-01-22

... Part III The President Proclamation 8473--Martin Luther King, Jr., Federal Holiday, 2010 Proclamation 8474--Religious Freedom Day, 2010 Notice of January 20, 2010--Continuation of the National... only by the power of his words, which still call on us to perfect those sacred ideals enshrined in our...

Mitu tundi strateegiat ühel lehel! / Martine Vanremoortele ; intervjueerinud Helen Unt

Index Scriptorium Estoniae

Vanremoortele, Martine

2014-01-01

Intervjuu kommunikatsiooni- ja turundustaustaga belglanna Martine Vanremoortelega visual harvesting-meetodist, mille abil salvestatakse grupi või esineja loodav sisu piltides või joonisel, eesmärgiks parandada inimestevahelist koostööd ja kaasata kõik osalejad mõtteprotsessi

A Call for Mathematics Education Colleagues and Stakeholders to Collaboratively Engage with NCTM: In Response to Martin's Commentary

Science.gov (United States)

Briars, Diane J.; Larson, Matt; Strutchens, Marilyn E.; Barnes, David

2015-01-01

In his commentary "The Collective Black and 'Principles to Actions,'" Martin (2015) offers a thought-provoking critique of "Principles to Actions: Ensuring Mathematical Success for All" (National Council of Teachers of Mathematics [NCTM], 2014). Martin (2015) states that the mathematics education community, in general, and the…

Lyapunov functions and global stability for SIR and SEIR models with age-dependent susceptibility

KAUST Repository

Korobeinikov, Andrei; Melnik, Andrey V.

2013-01-01

We consider global asymptotic properties for the SIR and SEIR age structured models for infectious diseases where the susceptibility depends on the age. Using the direct Lyapunov method with Volterra type Lyapunov functions, we establish conditions for the global stability of a unique endemic steady state and the infection-free steady state.

Martin Buber: eclipse de Deus e o Holocausto

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Renato Somberg Pfeffer

2007-10-01

Full Text Available Resumo: Este artigo analisa a questão da eclipse de Deus em Martin Buber. A experiência religiosa israelita parte de duas compreensões convergentes de Deus: Ele é o senhor da história e criador do mundo e do homem. Tudo que existe não se explica por si mesmo, tudo se remete ao criador. A partir desse ponto de vista, serão enfocados Deus e o Holocausto.

Determination of the Geographical Origin of All Commercial Hake Species by Stable Isotope Ratio (SIR) Analysis.

Science.gov (United States)

Carrera, Mónica; Gallardo, José M

2017-02-08

The determination of the geographical origin of food products is relevant to comply with the legal regulations of traceability, to avoid food fraud, and to guarantee food quality and safety to the consumers. For these reasons, stable isotope ratio (SIR) analysis using an isotope ratio mass spectrometry (IRMS) instrument is one of the most useful techniques for evaluating food traceability and authenticity. The present study was aimed to determine, for the first time, the geographical origin for all commercial fish species belonging to the Merlucciidae family using SIR analysis of carbon (δ 13 C) and nitrogen (δ 15 N). The specific results enabled their clear classification according to the FAO (Food and Agriculture Organization of the United Nations) fishing areas, latitude, and geographical origin in the following six different clusters: European, North African, South African, North American, South American, and Australian hake species.

Positron-emitting resin microspheres as surrogates of 90Y SIR-Spheres: a radiolabeling and stability study

International Nuclear Information System (INIS)

Avila-Rodriguez, Miguel A.; Selwyn, Reed G.; Hampel, Joseph A.; Thomadsen, Bruce R.; DeJesus, Onofre T.; Converse, Alexander K.; Nickles, Robert J.

2007-01-01

Commercially available resin microspheres and SIR-Spheres were labeled with metallic positron emitters and evaluated as positron emission tomography (PET) imaging surrogates of 90 Y SIR-Spheres. Radiolabeling was performed using a batch method, and in vitro stability over 24 h was evaluated in saline at physiological pH at 37 o C. The activity per microsphere distribution, as evaluated by autoradiography, showed the activity per microsphere to be proportional to the square radius of the spheres, suggesting surface binding. The in vivo stability of radiolabeling was evaluated in rats by micro-PET imaging after the intravenous injection of labeled microspheres. The different resin microspheres and radionuclides evaluated in this study all showed good radiolabeling efficiency and in vitro stability. However, only resins labeled with 86 Y and 89 Zr proved to have the in vivo stability required for clinical applications

The threshold of a stochastic delayed SIR epidemic model with temporary immunity

Science.gov (United States)

Liu, Qun; Chen, Qingmei; Jiang, Daqing

2016-05-01

This paper is concerned with the asymptotic properties of a stochastic delayed SIR epidemic model with temporary immunity. Sufficient conditions for extinction and persistence in the mean of the epidemic are established. The threshold between persistence in the mean and extinction of the epidemic is obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number R0 of the deterministic system.

Sir Winston Churchill: treatment for pneumonia in 1943 and 1944.

Science.gov (United States)

Vale, J A; Scadding, J W

2017-12-01

This paper reviews Churchill's illnesses in February 1943 and August/September 1944 when he developed pneumonia; on the first occasion this followed a cold and sore throat. Churchill was managed at home by Sir Charles Wilson (later Lord Moran) with the assistance of two nurses and the expert advice of Dr Geoffrey Marshall, Brigadier Lionel Whitby and Colonel Robert Drew. A sulphonamide (sulphathiazole on the first occasion) was prescribed for both illnesses. Churchill recovered, and despite his illnesses continued to direct the affairs of State from his bed. On the second occasion, Churchill's illness was not made public.

Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively.

Directory of Open Access Journals (Sweden)

Inbal Nussbaum

Full Text Available Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood, although deteriorated stress response is one of the hallmarks of aging. The budding yeast Saccharomyces cerevisiae is a valuable model organism to study the genetics of aging, because yeast ages within days and are amenable to genetic manipulations. As a unicellular organism, yeast has evolved robust systems to respond to environmental challenges. This response is orchestrated largely by the conserved transcription factor Hsf1, which in S. cerevisiae regulates expression of multiple genes in response to diverse stresses. Here we demonstrate that Hsf1 response to heat shock and oxidative stress deteriorates during yeast transition from exponential growth to stationary-phase, whereas Hsf1 activation by glucose starvation is maintained. Overexpressing Hsf1 does not significantly improve heat shock response, indicating that Hsf1 dwindling is not the major cause for Hsf1 attenuated response in stationary-phase yeast. Rather, factors that participate in Hsf1 activation appear to be compromised. We uncover two factors, Yap1 and Sir2, which discretely function in Hsf1 activation by oxidative stress and heat shock. In Δyap1 mutant, Hsf1 does not respond to oxidative stress, while in Δsir2 mutant, Hsf1 does not respond to heat shock. Moreover, excess Sir2 mimics the heat shock response. This role of the NAD+-dependent Sir2 is supported by our finding that supplementing NAD+ precursors improves Hsf1 heat shock response in stationary-phase yeast, especially when combined with expression of excess Sir2. Finally, the combination of excess Hsf1, excess Sir2 and NAD+ precursors rejuvenates the heat shock response.

Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively.

Science.gov (United States)

Nussbaum, Inbal; Weindling, Esther; Jubran, Ritta; Cohen, Aviv; Bar-Nun, Shoshana

2014-01-01

Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood, although deteriorated stress response is one of the hallmarks of aging. The budding yeast Saccharomyces cerevisiae is a valuable model organism to study the genetics of aging, because yeast ages within days and are amenable to genetic manipulations. As a unicellular organism, yeast has evolved robust systems to respond to environmental challenges. This response is orchestrated largely by the conserved transcription factor Hsf1, which in S. cerevisiae regulates expression of multiple genes in response to diverse stresses. Here we demonstrate that Hsf1 response to heat shock and oxidative stress deteriorates during yeast transition from exponential growth to stationary-phase, whereas Hsf1 activation by glucose starvation is maintained. Overexpressing Hsf1 does not significantly improve heat shock response, indicating that Hsf1 dwindling is not the major cause for Hsf1 attenuated response in stationary-phase yeast. Rather, factors that participate in Hsf1 activation appear to be compromised. We uncover two factors, Yap1 and Sir2, which discretely function in Hsf1 activation by oxidative stress and heat shock. In Δyap1 mutant, Hsf1 does not respond to oxidative stress, while in Δsir2 mutant, Hsf1 does not respond to heat shock. Moreover, excess Sir2 mimics the heat shock response. This role of the NAD+-dependent Sir2 is supported by our finding that supplementing NAD+ precursors improves Hsf1 heat shock response in stationary-phase yeast, especially when combined with expression of excess Sir2. Finally, the combination of excess Hsf1, excess Sir2 and NAD+ precursors rejuvenates the heat shock response.

The influence of percutaneous nephrolithotomy on human systemic stress response, SIRS and renal function.

Science.gov (United States)

Shen, Pengfei; Wei, Wuran; Yang, Xiaochun; Zeng, Hao; Li, Xiong; Yang, Jie; Wang, Jia; Huang, Jiaoti

2010-10-01

The objective of this study is to investigate the influences of percutaneous nephrolithotomy (PNL) and open surgery nephrolithotomy on the systemic stress response, SIRS and renal function. Forty patients with kidney calculi were enrolled in the study. Twenty cases were randomized to the PNL group and the other twenty cases to the open surgery group. Levels of C-reactive protein (CRP), interleukin-6(IL-6), β(2)-microglobulin (β(2)-MG), respiration rate, heart rate, body temperature and white blood cell counts were examined. CRP and IL-6 were measured in all patients pre-operatively and on post-operative days 1, 3 and 6, respectively. There was significant difference in their pre- and post-operation levels (P PNL group and 12 cases in open surgery group; there was significant difference between the two groups (P 0.05). Urine β(2)-MG levels were also measured. There was significant difference between pre- and the first day post-PNL (P PNL (P > 0.05). There was significant difference between pre- and first and third day post-open surgery (P 0.05). There was significant difference between two groups at the first, third and sixth days (P PNL group and open surgery group to some extent. The degree of stress response of PNL is lower than that of open surgery, proving the advantages of PNL with reference to serum immunology. There were cases in both the groups with SIRS, but the degree of SIRS in PNL group was lesser than the other group. Both the groups have no obvious effect on glomerular filtration function after operation and have effect on renal tubular reabsorption in the early stage after operation; but the recovery of the PNL group is faster than the open surgery group. It is thus shown that PNL is much safer and more feasible and has lesser effect on renal function.

Struktuur eri pikkusskaaladel = Structure on different length-scales / Salmaan Craig, Martin Melioranski

Index Scriptorium Estoniae

Craig, Salmaan

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonnaõppejõu Martin Melioranski vestluskaaslane Salmaan Craig on Harvard Graduate School of Design külalislektor ja töötab ühtlasi arhitektuuribüroos Foster + Partners

Medicinal use of earths and minerals from Hippocrates to Sir Hans Sloane and beyond.

Science.gov (United States)

Retsas, Spyros

2012-12-01

In 1931 two pharmaceutical drawers containing mineral specimens, belonging to Sir Hans Sloane, the 18th century collector, Royal Physician, President of the Royal Society and of the Royal College of Physicians of London, were found in the Department of Botany of the Natural History Museum (NHM) of London. The drawers, each divided into 49 compartments, contained a total of 107 mineral pharmaceutical specimens, some labelled as mercury or white arsenic. Their registration, identification with the Sloane Manuscript Catalogues and subsequent transfer to the Mineralogy department of the NHM where one of these drawers is now on public display, had been documented by 1935. In antiquity therapeutic empiricism attributed medicinal properties to animal products, plants and minerals, including the soil of specific geographic locations. This communication traces the medicinal use of certain earths and minerals, listed in Sir Hans Sloane's manuscript catalogues, to classical antiquity with a reference to Arsenic compounds, which in our time are finding application in the treatment of acute promyelocytic leukaemia and to Terra Lemnia, a celebrated antidote of repute spanning twenty centuries, also included in the Sloane collections.

The Threshold of a Stochastic SIRS Model with Vertical Transmission and Saturated Incidence

Directory of Open Access Journals (Sweden)

Chunjuan Zhu

2017-01-01

Full Text Available The threshold of a stochastic SIRS model with vertical transmission and saturated incidence is investigated. If the noise is small, it is shown that the threshold of the stochastic system determines the extinction and persistence of the epidemic. In addition, we find that if the noise is large, the epidemic still prevails. Finally, numerical simulations are given to illustrate the results.

Traveling waves in a delayed SIR model with nonlocal dispersal and nonlinear incidence

Science.gov (United States)

Zhang, Shou-Peng; Yang, Yun-Rui; Zhou, Yong-Hui

2018-01-01

This paper is concerned with traveling waves of a delayed SIR model with nonlocal dispersal and a general nonlinear incidence. The existence and nonexistence of traveling waves of the system are established respectively by Schauder's fixed point theorem and two-sided Laplace transform. It is also shown that the spread speed c is influenced by the dispersal rate of the infected individuals and the delay τ.

Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90α in Severe Sepsis and SIRS

Directory of Open Access Journals (Sweden)

K. Vardas

2014-01-01

Full Text Available Objective. To evaluate the early heat shock protein (HSP and hormonal stress response of intensive care unit (ICU patients with severe sepsis/septic shock (SS or systemic inflammatory response syndrome (SIRS compared to healthy subjects (H. Methods. Patients with early (first 48 hrs SS (n=29 or SIRS (n=29 admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72 and interleukins. Mean fluorescence intensity (MFI values for intracellular HSPs (iHSP72, iHSP90α were measured using 4-colour flow-cytometry. Results. Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H (P<0.003. ACTH and eHSP72 were significantly higher in SS and SIRS compared to H (P<0.005. SS monocytes expressed lower iHSP72 MFI levels compared to H (P=0.03. Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate (P<0.05. In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10. Conclusion. Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.

Harvardis õppiv eestlane väitles end maailmameistriks / Martin Kiik ; intervjueerinud Merle Must

Index Scriptorium Estoniae

Kiik, Martin

2013-01-01

Intervjuu Harvardi ülikoolis õppiva eestlase Martin Kiigega, kes saavutas ülikoolide väitluse maailmameistrivõistlustel inglise keelt teise keelena kõnelevate võistlejate arvestuses maailmameistritiitli

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Indian Academy of Sciences (India)

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Salt Lake City, UT, USA. Sir Martin J Evans – Cardiff University, Cardiff, United Kingdom. Oliver Smithies – University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Peace. “for their efforts to build up and disseminate greater knowledge about man-made climate change, and to lay the foundations for the measures ...

The threshold of a stochastic delayed SIR epidemic model with vaccination

Science.gov (United States)

Liu, Qun; Jiang, Daqing

2016-11-01

In this paper, we study the threshold dynamics of a stochastic delayed SIR epidemic model with vaccination. We obtain sufficient conditions for extinction and persistence in the mean of the epidemic. The threshold between persistence in the mean and extinction of the stochastic system is also obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number Rbar0 of the deterministic system. Results show that time delay has important effects on the persistence and extinction of the epidemic.

An individual-based approach to SIR epidemics in contact networks.

Science.gov (United States)

Youssef, Mina; Scoglio, Caterina

2011-08-21

Many approaches have recently been proposed to model the spread of epidemics on networks. For instance, the Susceptible/Infected/Recovered (SIR) compartmental model has successfully been applied to different types of diseases that spread out among humans and animals. When this model is applied on a contact network, the centrality characteristics of the network plays an important role in the spreading process. However, current approaches only consider an aggregate representation of the network structure, which can result in inaccurate analysis. In this paper, we propose a new individual-based SIR approach, which considers the whole description of the network structure. The individual-based approach is built on a continuous time Markov chain, and it is capable of evaluating the state probability for every individual in the network. Through mathematical analysis, we rigorously confirm the existence of an epidemic threshold below which an epidemic does not propagate in the network. We also show that the epidemic threshold is inversely proportional to the maximum eigenvalue of the network. Additionally, we study the role of the whole spectrum of the network, and determine the relationship between the maximum number of infected individuals and the set of eigenvalues and eigenvectors. To validate our approach, we analytically study the deviation with respect to the continuous time Markov chain model, and we show that the new approach is accurate for a large range of infection strength. Furthermore, we compare the new approach with the well-known heterogeneous mean field approach in the literature. Ultimately, we support our theoretical results through extensive numerical evaluations and Monte Carlo simulations. Published by Elsevier Ltd.

Isonicotinamide Enhances Sir2 Protein-mediated Silencing and Longevity in Yeast by Raising Intracellular NAD+ Concentration*

Science.gov (United States)

McClure, Julie M.; Wierman, Margaret B.; Maqani, Nazif; Smith, Jeffrey S.

2012-01-01

Sirtuins are an evolutionarily conserved family of NAD+-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD+ concentration through the combined action of NAD+ biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD+ precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the nicotinamidase Pnc1 converts NAM to nicotinic acid (NA), which is then used as a substrate by the NAD+ salvage pathway enzyme NA phosphoribosyltransferase (Npt1). Isonicotinamide (INAM) is an isostere of NAM that stimulates yeast Sir2 deacetylase activity in vitro by alleviating the NAM inhibition. In this study, we determined that INAM stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD+ concentration. INAM enhanced normal silencing at the rDNA locus but only partially suppressed the silencing defects of an npt1Δ mutant. Yeast cells grown in media lacking NA had a short replicative life span, which was extended by INAM in a SIR2-dependent manner and correlated with increased NAD+. The INAM-induced increase in NAD+ was strongly dependent on Pnc1 and Npt1, suggesting that INAM increases flux through the NAD+ salvage pathway. Part of this effect was mediated by the NR salvage pathways, which generate NAM as a product and require Pnc1 to produce NAD+. We also provide evidence suggesting that INAM influences the expression of multiple NAD+ biosynthesis and salvage pathways to promote homeostasis during stationary phase. PMID:22539348

Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.

Science.gov (United States)

McClure, Julie M; Wierman, Margaret B; Maqani, Nazif; Smith, Jeffrey S

2012-06-15

Sirtuins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD(+) concentration through the combined action of NAD(+) biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD(+) precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the nicotinamidase Pnc1 converts NAM to nicotinic acid (NA), which is then used as a substrate by the NAD(+) salvage pathway enzyme NA phosphoribosyltransferase (Npt1). Isonicotinamide (INAM) is an isostere of NAM that stimulates yeast Sir2 deacetylase activity in vitro by alleviating the NAM inhibition. In this study, we determined that INAM stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD(+) concentration. INAM enhanced normal silencing at the rDNA locus but only partially suppressed the silencing defects of an npt1Δ mutant. Yeast cells grown in media lacking NA had a short replicative life span, which was extended by INAM in a SIR2-dependent manner and correlated with increased NAD(+). The INAM-induced increase in NAD(+) was strongly dependent on Pnc1 and Npt1, suggesting that INAM increases flux through the NAD(+) salvage pathway. Part of this effect was mediated by the NR salvage pathways, which generate NAM as a product and require Pnc1 to produce NAD(+). We also provide evidence suggesting that INAM influences the expression of multiple NAD(+) biosynthesis and salvage pathways to promote homeostasis during stationary phase.

Microstrip Cross-coupled Interdigital SIR Based Bandpass Filter

Directory of Open Access Journals (Sweden)

R. K. Maharjan

2012-09-01

Full Text Available A simple and compact 4.9 GHz bandpass filter for C-band applications is proposed. This paper presents a novel microstrip cross-coupled interdigital half-wavelength stepped impedance resonator (SIR based bandpass filter (BPF.The designed structure is similar to that of a combination of two parallel interdigital capacitors. The scattering parameters of the structure are measured using vector network analyzer (VNA. The self generated capacitive and inductive reactances within the interdigital resonators exhibited in a resonance frequency of 4.9 GHz. The resonant frequency and bandwidth of the capacitive cross-coupled resonator is directly optimized from the physical arrangement of the resonators. The measured insertion loss (S21 and return loss (S11 were 0.3 dB and 28 dB, respectively, at resonance frequency which were almost close to the simulation results.

Sir Charles Alfred Ballance (1856-1936) and the introduction of facial nerve crossover anastomosis in 1895

NARCIS (Netherlands)

Van de Graaf, Robert C.; Ijpma, Frank F. A.; Nicolai, Jean-Philippe A.

Sir Charles Ballance (1856-1936) was the first surgeon in history to perform a facial nerve crossover anastomosis in 1895. Although, recently, several papers on the history of facial nerve surgery have been published, little is known about this historically important operation, the theoretical

Social marketing and MARTIN: tools for organizing, analyzing, and interpreting qualitative data.

Science.gov (United States)

Higgins, J W

1998-11-01

The purpose of this article is to discuss how the computer software program MARTIN and social marketing concepts (understanding the consumer perspective, exchange, marketing mix, and segmentation) were used as organizational, analytical, and interpretive tools for qualitative data. The qualitative data are from a case study on citizen participation in a health reform policy in British Columbia. The concept of broad-based public participation is a fundamental element of health promotion and citizenship. There is a gap, however, between the promise and reality of citizen participation in health promotion. Emerging from the analysis was an understanding of the societal circumstances that inhibited or fostered participation. This article describes how the code-based, theory-building attributes of the MARTIN software facilitated a new conceptualization of participatory citizenship and generated new insights into understanding why some people participate and others do not.

The β-1,3-glucanosyltransferase Gas1 regulates Sir2-mediated rDNA stability in Saccharomyces cerevisiae.

Science.gov (United States)

Ha, Cheol Woong; Kim, Kwantae; Chang, Yeon Ji; Kim, Bongkeun; Huh, Won-Ki

2014-07-01

In Saccharomyces cerevisiae, the stability of highly repetitive rDNA array is maintained through transcriptional silencing. Recently, a β-1,3-glucanosyltransferase Gas1 has been shown to play a significant role in the regulation of transcriptional silencing in S. cerevisiae. Here, we show that the gas1Δ mutation increases rDNA silencing in a Sir2-dependent manner. Remarkably, the gas1Δ mutation induces nuclear localization of Msn2/4 and stimulates the expression of PNC1, a gene encoding a nicotinamidase that functions as a Sir2 activator. The lack of enzymatic activity of Gas1 or treatment with a cell wall-damaging agent, Congo red, exhibits effects similar to those of the gas1Δ mutation. Furthermore, the loss of Gas1 or Congo red treatment lowers the cAMP-dependent protein kinase (PKA) activity in a cell wall integrity MAP kinase Slt2-dependent manner. Collectively, our results suggest that the dysfunction of Gas1 plays a positive role in the maintenance of rDNA integrity by decreasing PKA activity and inducing the accumulation of Msn2/4 in the nucleus. It seems that nuclear-localized Msn2/4 stimulate the expression of Pnc1, thereby enhancing the association of Sir2 with rDNA and promoting rDNA stability. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Sir Robert Ball: Victorian Astronomer and Lecturer par excellence

Science.gov (United States)

Jones, R. I. G.

2005-12-01

Between 1875 and 1910 Sir Robert Stawell Ball gave an estimated 2,500 lectures in towns and cities all over the British Isles and abroad. This paper traces his lecturing career from its beginnings in Ireland to the triumphs of the Royal Institution, and on lecture tours in the United States of America. After a period in mathematics and mechanics, he became a populariser of science, especially astronomy, and found fame and fortune among the working classes and the aristocracy. What motivated him to tireless travels is uncertain, but it might have been that it was rewarding, financially and to his reputation. Whatever his motives, contemporary accounts are clear that BallÕs lectures were extremely popular and well-received.

The Bertlmann-Martin Inequalities and the Uncertainty Principle

International Nuclear Information System (INIS)

Ighezou, F.Z.; Kerris, A.T.; Lombard, R.J.

2008-01-01

A lower bound to (r) 1s is established from the Thomas-Reiche-Kuhn sum rule applied to the reduced equation for the s-states. It is linked to the average value of (r 2 ) 1s We discuss, on few examples, how the use of approximate value for (r 2 ) 1s , derived from the generalized Bertlmann and Martin inequalities, preserves the lower bound character of (r) 1s . Finally, by using the uncertainty principle and the uncertainty in the radial position, we derive a low bound to the ground state kinetic energy

Sea trials of MARTIN - a European survey AUV

DEFF Research Database (Denmark)

Henriksen, Lars; Bjerrum, A.; Ishoy, A.

1995-01-01

are currently being performed. A new navigation system has been developed for MARTIN. The low-drag flat-fish shaped, modular designed hull has been thoroughly tested in a towing tank and in the open sea. The hydrodynamic parameters were used in computer simulations of the vehicle dynamics. An autopilot based...... software was developed by the Institute of Automation, Danish Technical University in co-operation with Reson AS and Maridan ApS. The paper includes a description of the navigation system, results from simulations and preliminary results from the first sea trials...

The projects of skunk works 75 years of Lockheed Martin's advanced development programs

CERN Document Server

Pace, Steve

2016-01-01

The Projects of Skunk Works examines 75 years of Lockheed Martin's advanced development programs, from jet fighters to missiles, heavy-lift helicopters, a lighter-than-air ship, drones, and a stealth boat.

New approaches to improve a WCDMA SIR estimator by employing different post-processing stages

Directory of Open Access Journals (Sweden)

Amnart Chaichoet

2008-09-01

Full Text Available For effective control of transmission power in WCDMA mobile systems, a good estimate of signal-to-interference ratio (SIR is needed. Conventionally, an adaptive SIR estimator employs a moving average (MA filter (Yoon et al., 2002 to encounter fading channel distortion. However, the resulting estimate seems to have high estimation error due to fluctuation in the channel variation. In this paper, an additional post-processing stage is proposed to improve the estimation accuracy by reducing the variation of the estimate. Four variations of post-processing stages, namely 1 a moving average (MA postfilter,2 an exponential moving average (EMA post-filter, 3 an IIR post-filter and 4 least-mean-squared (LMS adaptive post-filter, are proposed and their optimal performance in terms of root-mean-square error (RMSE are then compared by simulation. The results show the best comparable performance when the MA and LMS post-filter are used. However, the MA post-filter requires a lookup table of filter order for optimal performance at different channel conditions, while the LMS post-filter can be used conveniently without a lookup table.

Alice-Anne Martin (1926 - 2016)

CERN Multimedia

2016-01-01

Alice-Anne Martin, known as “Schu” from her maiden name Schubert, passed away on 8 January 2016.   (Image: Gérard Bertin) Hired the year CERN was founded, 1954, when the construction of the Laboratory had not even begun, Schu first worked at the Villa de Cointrin (a historic building now within the grounds of Geneva airport) as a secretary. In this role, she typed the convention between CERN and the Swiss Confederation, prepared by Stéphanie Tixier, as well as some of the "Yellow Reports" that have marked key points in the Laboratory’s history. For example, using a special typewriter with two keyboards – Latin and Greek – she typed the Yellow Report on the KAM theorem by Rolf Hagedorn. Schu also worked with Felix Bloch, the first Director-General of CERN, and later became the secretary of Herbert Coblenz, the first CERN librarian. She was head of the team that edited the proceedings of the ...

Design of power controller in CDMA system with power and SIR error minimization

Institute of Scientific and Technical Information of China (English)

Shulan KONG; Huanshui ZHANG; Zhaosheng ZHANG; Hongxia WANG

2007-01-01

In this paper, an uplink power control problem is considered for code division multiple access (CDMA) systems. A distributed algorithm is proposed based on linear quadratic optimal control theory. The proposed scheme minimizes the sum of the power and the error of signal-to-interference ratio (SIR). A power controller is designed by constructing an optimization problem of a stochastic linear quadratic type in Krein space and solving a Kalman filter problem.

Nuclear data uncertainties for local power densities in the Martin-Hoogenboom benchmark

International Nuclear Information System (INIS)

Van der Marck, S.C.; Rochman, D.A.

2013-01-01

The recently developed method of fast Total Monte Carlo to propagate nuclear data uncertainties was applied to the Martin-Hoogenboom benchmark. This Martin- Hoogenboom benchmark prescribes that one calculates local pin powers (of light water cooled reactor) with a statistical uncertainty lower than 1% everywhere. Here we report, for the first time, an estimate of the nuclear data uncertainties for these local pin powers. For each of the more than 6 million local power tallies, the uncertainty due to nuclear data uncertainties was calculated, based on random variation of data for 235 U, 238 U, 239 Pu and H in H 2 O thermal scattering. In the center of the core region, the nuclear data uncertainty is 0.9%. Towards the edges of the core, this uncertainty increases to roughly 3%. The nuclear data uncertainties have been shown to be larger than the statistical uncertainties that the benchmark prescribes

Advancing description and explanation in clinical linguistics: a legacy of Martin J. Ball.

Science.gov (United States)

Damico, Jack S; Damico, Holly L; Nelson, Ryan L

2011-11-01

This article asserts the importance of explication of order and disorder in language as a privileged objective of clinical linguistics and service delivery and reviews the contributions of Martin Ball in advancing this agenda.

The Caldwell Objects and How to Observe Them

CERN Document Server

Mobberley, Martin

2009-01-01

There have been only a handful of famous deep sky "catalogs," including Charles Messier’s, which was the first and remains the most famous. Messier was a comet hunter, and in the late 1700s he published a list of 109 objects in the sky that were not comets. In December 1995, Sky & Telescope published a list of deep sky objects sent to them by British amateur astronomer extraordinare, Sir Patrick Moore (officially, Sir Patrick Caldwell-Moore). It was a huge hit! Sir Patrick may be the most prolific authors of astronomy books for all time and has been presenting the BBC Sky at Night television series since April 1957. Moore’s list contained 109 non-Messier objects that were Patrick’s favorites, many of them visible only in the southern hemisphere. Accompanying the list of objects were long exposure black and white and color photographs of some of these objects. In this book Martin Mobberley, who has known Sir Patrick Moore for many years, describes these objects and tells how to locate them. He discus...

Crystallization and preliminary X-ray diffraction studies of the putative haloalkane dehalogenase DppA from Plesiocystis pacifica SIR-I

International Nuclear Information System (INIS)

Bogdanović, Xenia; Hesseler, Martin; Palm, Gottfried J.; Bornscheuer, Uwe T.; Hinrichs, Winfried

2010-01-01

The crystallization and preliminary X-ray diffraction studies of DppA from P. pacifica SIR-I are reported. DppA from Plesiocystis pacifica SIR-I is a putative haloalkane dehalogenase (EC 3.8.1.5) and probably catalyzes the conversion of halogenated alkanes to the corresponding alcohols. The enzyme was expressed in Escherichia coli BL21 and purified to homogeneity by ammonium sulfate precipitation and reversed-phase and ion-exchange chromatography. The DppA protein was crystallized by the vapour-diffusion method and protein crystals suitable for data collection were obtained in the orthorhombic space group P2 1 2 1 2. The DppA crystal diffracted X-rays to 1.9 Å resolution using an in-house X-ray generator

One day, Sir, you may tax it

CERN Multimedia

2011-01-01

“One day, Sir, you may tax it”… Those are the words I used to get the audience's attention during my talk at the World Economic Forum’s annual meeting in Davos, where I was invited to speak about the science agenda in 2011. For those of you who don’t know the quote, it was Michael Faraday’s response to William Gladstone when asked to comment on the utility of his blue-sky research into the newfangled phenomenon of electricity.   So what does a 19th century English scientist have to do with the science agenda today? A great deal, I would contend. Faraday was doing basic science, but he had the foresight to realise that through applied research his findings could one day be developed into something taxable – as it turned out, electric light. Faraday had a sense of the potential of his blue-sky research, but he also appreciated that basic science alone is not enough. This was my key message in Davos. Governments often speak of ...

Autonomous Women in a Drawer: Carmen Martin Gaite's "La hermana pequena"

Science.gov (United States)

Garcia, Adrian M.

2009-01-01

Martin Gaite's only Franco-era play contests some fundamental Catholic and Francoist prescriptions for the female. The fact that it was not published or performed for nearly forty years is likely due at least in part to patriarchal censorship. The work dramatizes the personal development of two half-sisters who defy various gender norms and…

Pronouncing that being is nothing in the work of Martin Heidegger

Directory of Open Access Journals (Sweden)

Grbić Safer

2017-01-01

Full Text Available Raising a question of Being, anew, after it had fallen into oblivion, was initiated by Martin Heidegger and that marked his complete philosophical work. Along those lines, the paper titled 'Pronouncing That Being is Nothing in the Work of Martin Heidegger' briefly discusses the history of the question of Being starting from the Parmenides' research on the topic, through Christian dogma, Hegel's Science of Logic and establishing Being-Dasein-Nothing, all the way to the Heidegger's distinction among Being, Dasein, and Nothing in the anxiety phenomenon along the lines of existential thinking of Kierkegaard. The hypothesis as a judgment that is presumed to be true in order to explain certain facts with it or as an assumption on the basis of facts reflects in the thesis that Heidegger, asking the question about the meaning of Being and the tendency of getting to his concept in the anxiety phenomenon, especially in his later speeches, gets to pronounce that Being is Nothing, without providing final answers, but considering that just asking the question about such a relation is a success.

Response to Hans Thulesius and Vivian B. Martin on Ekins (2011

Directory of Open Access Journals (Sweden)

Richard Ekins, Ph.D., FRSA

2011-12-01

Full Text Available I appreciate the valuable comments from Hans Thulesius and Vivian Martin. Both reviewers usefully and most helpfully pinpoint salient issues to be considered in forging future routes for my ongoing research in jazz historiography. I agree with Vivian Martin that ‘authenticating’ works better for early jazz and first wave USA revivalism (including Bunk Johnson and would like to say that at the time I wrote the abstract, I was favouring ‘managing authenticity’ over ‘authenticating’ as the core category in order to provide a more embracive category within which to consider early jazz, the 1940s New Orleans jazz revival (including Bunk Johnson, and the world-wide New Orleans jazz revivalist movement which continues to this day. I have, indeed, written elsewhere of all the various phases of New Orleans style jazz considered in terms of the core category/basic social process of ‘authenticating’, e.g., ‘Authenticity as Authenticating – The Case of New Orleans Jazz Revivalism: An Approach from Grounded Theory and Social World Analysis’ (Ekins, forthcoming.

Clinical repercussions of Martin-Gruber anastomosis: anatomical study

Directory of Open Access Journals (Sweden)

Cristina Schmitt Cavalheiro

2016-04-01

Full Text Available OBJECTIVE: The main objective of this study was to describe Martin-Gruber anastomosis anatomically and to recognize its clinical repercussions. METHOD: 100 forearms of 50 adult cadavers were dissected in an anatomy laboratory. The dissection was performed by means of a midline incision along the entire forearm and the lower third of the upper arm. Two flaps including skin and subcutaneous tissue were folded back on the radial and ulnar sides, respectively. RESULTS: Nerve communication between the median and ulnar nerves in the forearm (Martin-Gruber anastomosis was found in 27 forearms. The anastomosis was classified into six types: type I: anastomosis between the anterior interosseous nerve and the ulnar nerve (n = 9; type II: anastomosis between the anterior interosseous nerve and the ulnar nerve at two points (double anastomosis (n = 2; type III: anastomosis between the median nerve and the ulnar nerve (n = 4; type IV: anastomosis between branches of the median nerve and ulnar nerve heading toward the flexor digitorum profundus muscle of the fingers; these fascicles form a loop with distal convexity (n = 5; type V: intramuscular anastomosis (n = 5; and type VI: anastomosis between a branch of the median nerve to the flexor digitorum superficialis muscle and the ulnar nerve (n = 2. CONCLUSION: Knowledge of the anatomical variations relating to the innervation of the hand has great importance, especially with regard to physical examination, diagnosis, prognosis and surgical treatment. If these variations are not given due regard, errors and other consequences will be inevitable.

Redescription of Lutzomyia (Lutzomyia souzalopesi Martins, Silva & Falcão, 1970 (Diptera, Psychodidae, Phlebotominae

Directory of Open Access Journals (Sweden)

Edelberto Santos Dias

1996-04-01

Full Text Available The authors redescribe the male and the female of Lutzomyia (Lutzomyia souzalopesi Martins, Silva & Falcão, 1970. Taxonomic remarks, geographic distribution and drawings are presented.

Kõik on nii nagu enne, aga miski pole enam endine / Martin Rünk

Index Scriptorium Estoniae

Rünk, Martin

2010-01-01

Anders Härmi kuraatoriprojekt "Next to Nothing" ("Eimillestki edasi") Eesti Kaasaegse Kunsti Muuseumis 22. augustini 2010. Pikemalt Martin Creedi (Suurbritannia), Laura Tootsi, Triin Tamme, Dénes Farkasi, Neeme Külma ja Kaido Ole töödest

Thermal vacuum test of space equipment: tests of SIR-2 instrument Chandrayaan-1 mission

Science.gov (United States)

Sitek, P.

2008-11-01

We describe the reasons of proceeding Thermal-Vacuum tests for space electronic. We will answer on following questions: why teams are doing TV tests, what kind of phases should be simulated, which situations are the most critical during TV tests, what kind of results should be expected, which errors can be detect. As an example, will be shown TV-test of SIR-2 instrument for Chandrayaan-1 moon mission.

The Kimber-Martin-Ryskin unintegrated partons via the MRST and GRV parametrizations

International Nuclear Information System (INIS)

Modarres, M.; Hosseinkhani, H.

2009-01-01

We consider the GRV98 (Glueck et al.) and MRST99 (Martin et al.) sets of parton distribution functions (PDFs) as the inputs to obtain the unintegrated PDFs (UPDFs) via the Kimber-Martin-Ryskin (KMR) procedure. The ratios of MRST99 to GRV98 for both PDFs and UPDFs are compared. Since UPDFs are two scales dependent functions (namely k t 2 and μ 2 ), by fixing the values of k t 2 or μ 2 , their relative behaviors for the wide range of μ 2 or k t 2 are investigated. It is shown that by increasing k t 2 the UPDFs are shifted toward the larger values of the scale μ 2 . Finally, it is observed that the KMR procedure is not only stable and insensitive to the variation of input sets of partons such as those of GRV or MRST, but also it has this ability to suppress these discrepancies to make the unique and reliable outputs for UPDFs

Lockheed Martin T-Rex: Preliminary report

International Nuclear Information System (INIS)

1997-01-01

T-Rex is a robot which may be used in toxic or flammable environments. The assessment of the T-Rex conducted at the Lockheed Martin facility was limited in its scope. The scope of the assessment was directed by the type of equipment being used and the amount of accessibility to the equipment. Due to severe time constraints--the assessment was conducted in one day--human factors interface activities were limited. This should be considered a preliminary assessment. This report covers aspects of the technology that were available to the assessment team. Recommendations for future evaluation of this technology are also included. The contents are as follows: Electrical Considerations; General Electrical Consideration; Trailing Cables; Grounding; Surface High Voltage Distribution; Low and Medium Voltage Alternating Current Circuits; Potential for Harmful Human Factor Incidents and Enterprise Disablement; Exclusion Zone Emergency Maintenance; and Recommendations

Cerebral arterio-venous malformations at Edgardo Rebagliati Martins Nacional Hospital

OpenAIRE

Rabanal, Jorge

2014-01-01

A review of 50 cases with cerebral arterio.venous malformations (AVM) treated since Junly 1988 through December 1992 in the Neurosurgery Service from Edgardo Rebagliati Martins National Hospital was done. Clinical records, surgical techniques and pre- and post-operative studies were evaluted by retrospective analysis. The more important results were the frecuency of presentations in male patients from the coast, the clinical onset with intracraneal hemorrhage, the operative technique of drain...

Le système du risque à Saint-Martin (Petites Antilles françaises

Directory of Open Access Journals (Sweden)

Virginie Duvat

2008-11-01

Full Text Available L’île de Saint-Martin constitue un terrain particulièrement intéressant pour étudier le système du risque naturel et les conditions de la co-évolution territoire/catastrophes. Les mécanismes qui s’y observent renforcent sa vulnérabilité et l’efficacité du retour d’expérience est affaiblie par des blocages d’ordre politique et juridique.The island of Saint-Martin is an interesting case study for a systemic approach applied to cyclone hazards and the co-evolution of territory and disaster management. The mecanisms which can be observed increase its vulnerability and the progress of hazard management policies is weakened by political and juridical bottlenecks.

Millisele õpetajale kingiksite imerohu? / Karl Martin Sinijärv, Vahur Keller, Kaarel Tarand ... [jt.

Index Scriptorium Estoniae

2010-01-01

Küsimusele vastavad: Eesti kirjanike liidu esimees Karl Martin Sinijärv, nuku- ja noorsooteatri lavastaja Vahur Keller, Sirbi peatoimetaja Kaarel Tarand, kirjanik Andrus Kivirähk, ajakirjanik Juhani Püttsepp

Martin Boundary of a Fine Domain and a Fatou-Naïm-Doob Theorem for Finely Superharmonic Functions

DEFF Research Database (Denmark)

El Kadiri, Mohamed; Fuglede, Bent

2016-01-01

We construct the Martin compactification U ¯ ¯ ¯ ¯    of a fine domain U in R n (n = 2) and the Riesz-Martin kernel K on U×U ¯ ¯ ¯ ¯    . We obtain the integral representation of finely superharmonic fonctions ≥ 0 on U in terms of K and establish the Fatou-Naim-Doob theorem in this setting....

Empiricism, Scientism, and Sciolism in Psychological Counselling and Therapy: Reaction to Martin.

Science.gov (United States)

Barak, Azy

1995-01-01

Reacts to Martin's (1995) essay concerning scientism in psychotherapy. Argues that the lack of understanding concerning the effectiveness of psychotherapy is reason for further examination, rather than a questioning of principles of research. The limited observation and measurement means of the behavioral sciences may account for the significant…

Sawtooth events and O+ in the plasma sheet and boundary layer: CME- and SIR-driven events

Science.gov (United States)

Lund, E. J.; Nowrouzi, N.; Kistler, L. M.; Cai, X.; Liao, J.

2017-12-01

The role of ionospheric ions in sawtooth events is an open question. Simulations[1,2,3] suggest that O+ from the ionosphere produces a feedback mechanism for driving sawtooth events. However, observational evidence[4,5] suggest that the presence of O+ in the plasma sheet is neither necessary nor sufficient. In this study we investigate whether the solar wind driver of the geomagnetic storm has an effect on the result. Building on an earlier study[4] that used events for which Cluster data is available in the plasma sheet and boundary layer, we perform a superposed epoch analysis for coronal mass ejection (CME) driven storms and streaming interaction region (SIR) driven storms separately, to investigate the hypothesis that ionospheric O+ is an important contributor for CME-driven storms but not SIR-driven storms[2]. [1]O. J. Brambles et al. (2011), Science 332, 1183.[2]O. J. Brambles et al. (2013), JGR 118, 6026.[3]R. H. Varney et al. (2016), JGR 121, 9688.[4]J. Liao et al. (2014), JGR 119, 1572.[5]E. J. Lund et al. (2017), JGR, submitted.

Dynamical Analysis of SIR Epidemic Models with Distributed Delay

Directory of Open Access Journals (Sweden)

Wencai Zhao

2013-01-01

Full Text Available SIR epidemic models with distributed delay are proposed. Firstly, the dynamical behaviors of the model without vaccination are studied. Using the Jacobian matrix, the stability of the equilibrium points of the system without vaccination is analyzed. The basic reproduction number R is got. In order to study the important role of vaccination to prevent diseases, the model with distributed delay under impulsive vaccination is formulated. And the sufficient conditions of globally asymptotic stability of “infection-free” periodic solution and the permanence of the model are obtained by using Floquet’s theorem, small-amplitude perturbation skills, and comparison theorem. Lastly, numerical simulation is presented to illustrate our main conclusions that vaccination has significant effects on the dynamical behaviors of the model. The results can provide effective tactic basis for the practical infectious disease prevention.

Mercury in the gold mining district of San Martin de Loba, South of Bolivar (Colombia).

Science.gov (United States)

Olivero-Verbel, Jesus; Caballero-Gallardo, Karina; Turizo-Tapia, Alexi

2015-04-01

Gold mining is responsible for most Hg pollution in developing countries. The aims of this study were to assess the levels of total Hg (T-Hg) in human hair, fish, water, macrophyte, and sediment samples in the gold mining district of San Martin de Loba, Colombia, as well as to determine fish consumption-based risks for T-Hg ingestion. T-Hg levels were measured by electrothermal atomization and atomic absorption spectroscopy. The overall mean T-Hg level in hair for humans in the mining district of San Martin de Loba was 2.12 μg/g, whereas for the reference site, Chimichagua, Cesar, it was 0.58 μg/g. Mean T-Hg levels were not different when considered within localities belonging to the mining district but differed when the comparison included Chimichagua. T-Hg levels in examined locations were weakly but significantly associated with age and height, as well as with fish consumption, except in San Martin de Loba. High T-Hg concentrations in fish were detected in Pseudoplatystoma magdaleniatum, Caquetaia kraussii, Ageneiosus pardalis, Cyrtocharax magdalenae, and Triportheus magdalenae, whereas the lowest appeared in Prochilodus magdalenae and Hemiancistrus wilsoni. In terms of Hg exposure due to fish consumption, only these last two species offer some guarantee of low risk for Hg-related health problems. Water, floating macrophytes, and sediments from effluents near mining sites also had high Hg values. In mines of San Martin de Loba and Hatillo de Loba, for instance, the geoaccumulation index (I(geo)) for sediments reached values greater than 6, indicating extreme pollution. In short, these data support the presence of a high Hg-polluted environment in this mining district, with direct risk for deleterious effects on the health of the mining communities.

Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine.

Science.gov (United States)

McILwain, R Britt; Timpa, Joseph G; Kurundkar, Ashish R; Holt, David W; Kelly, David R; Hartman, Yolanda E; Neel, Mary Lauren; Karnatak, Rajendra K; Schelonka, Robert L; Anantharamaiah, G M; Killingsworth, Cheryl R; Maheshwari, Akhil

2010-01-01

Extracorporeal membrane oxygenation (ECMO) is a life-saving support system used in neonates and young children with severe cardiorespiratory failure. Although ECMO has reduced mortality in these critically ill patients, almost all patients treated with ECMO develop a systemic inflammatory response syndrome (SIRS) characterized by a 'cytokine storm', leukocyte activation, and multisystem organ dysfunction. We used a neonatal porcine model of ECMO to investigate whether rising plasma concentrations of inflammatory cytokines during ECMO reflect de novo synthesis of these mediators in inflamed tissues, and therefore, can be used to assess the severity of ECMO-related SIRS. Previously healthy piglets (3-week-old) were subjected to venoarterial ECMO for up to 8 h. SIRS was assessed by histopathological analysis, measurement of neutrophil activation (flow cytometry), plasma cytokine concentrations (enzyme immunoassays), and tissue expression of inflammatory genes (PCR/western blots). Mast cell degranulation was investigated by measurement of plasma tryptase activity. Porcine neonatal ECMO was associated with systemic inflammatory changes similar to those seen in human neonates. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) concentrations rose rapidly during the first 2 h of ECMO, faster than the tissue expression of these cytokines. ECMO was associated with increased plasma mast cell tryptase activity, indicating that increased plasma concentrations of inflammatory cytokines during ECMO may result from mast cell degranulation and associated release of preformed cytokines stored in mast cells. TNF-alpha and IL-8 concentrations rose faster in plasma than in the peripheral tissues during ECMO, indicating that rising plasma levels of these cytokines immediately after the initiation of ECMO may not reflect increasing tissue synthesis of these cytokines. Mobilization of preformed cellular stores of inflammatory cytokines such as in mucosal mast cells may have

The Apocalyptic War Against Gog Of Magog. Martin Buber versus Meir Kahane

NARCIS (Netherlands)

Sneller, H.W.

2015-01-01

In this article a confrontation on the classic Gog/Magog motive (end time battle between God and evil) is enacted between two opposite Jewish thinkers: Martin Buber and Meir Kahane. It shows how and on what conditions the biblical text can be interpreted so differently. The article also tries to

Martin Creed: "Tahan luua keskkonna, kus on hea olla" / intervjueerinud Maria Arusoo

Index Scriptorium Estoniae

Creed, Martin, 1968-

2011-01-01

Tallinna Kunstihoones 29. sept.-l publikuga kohtunud inglise kunstnik, muusik ja teoreetik Martin Creed endast, oma loomingust, loomeprotsessist, oma Turner Prize'i pälvinud installatsioonist "Work No 227. Lights going on and off", mis oli väljas näitusel "Continuum_Kunst kui taju. Ruum kui protsess" jm.

Analysis of Active Lava Flows on Kilauea Volcano, Hawaii, Using SIR-C Radar Correlation Measurements

Science.gov (United States)

Zebker, H. A.; Rosen, P.; Hensley, S.; Mouginis-Mark, P. J.

1995-01-01

Precise eruption rates of active pahoehoe lava flows on Kilauea volcano, Hawaii, have been determined using spaceborne radar data acquired by the Space Shuttle Imaging Radar-C (SIR-C). Measurement of the rate of lava flow advance, and the determination of the volume of new material erupted in a given period of time, are among the most important observations that can be made when studying a volcano.

Timing, Nest Site Selection and Multiple Breeding in House Martins: Age-Related Variation and the Preference for Self-Built Mud Nests

NARCIS (Netherlands)

Piersma, T.

2013-01-01

Almost all accounts of the reproductive biology of House Martins Delichon urbicum are based on studies of birds breeding in artificial nests that are monitored every few days. Here, I provide a study on House Martins using self-built mud nests at a single colony in Gaast, The Netherlands (225 nest

Timing, nest site selection and multiple breeding in House Martins : age-related variation and the preference for self-built mud nests

NARCIS (Netherlands)

Piersma, Theunis

2013-01-01

Almost all accounts of the reproductive biology of House Martins Delichon urbicum are based on studies of birds breeding in artificial nests that are monitored every few days. Here, I provide a study on House Martins using self-built mud nests at a single colony in Gaast, The Netherlands (225 nest

Geological and radiometric study of the anomaly ''San Martin'' municipality of Sierra Mojada, Coahuila

International Nuclear Information System (INIS)

Ibarra Mora, P.

1975-01-01

When it first became known that there were uranium ores at the mine known as San Martin (72 hectares, Mining Agency, Sabinas, Mexico), exploration work was started with the sinking of two wells at the sites of maximum radiometric intensity. A short while afterwards, however, this work was suspended. In 1974, the work required for evaluation of the locality was begun. Geological and radiometric studies carried out both at the surface and underground pointed to the conclusion that the San Martin anomaly, down to the depth explored (40 metres), is a stockwork-type deposit or a tabular seam of the fissure type. It was concluded that in view of the grades obtained (0.0227%U 3 O 6 ) down to 40 metres, the deposit cannot be considered of econimic importance at the present time. (author)

On the Path towards Thinking: Learning from Martin Heidegger and Rudolf Steiner

Science.gov (United States)

Dahlin, Bo

2009-01-01

This paper is a philosophical study of the nature of thinking based on the philosophies of Martin Heidegger and Rudolf Steiner. For Heidegger, the pre-Socratic Greek philosophers exemplified genuine thinking, appreciating the meaning of Being. But this kind of philosophy was soon replaced by the onto-theological approach, in which Being was…

Seisak toob tööd juurde / Martin Kõdar ; interv. Villu Zirnask

Index Scriptorium Estoniae

Kõdar, Martin

2008-01-01

BaltCapi partner selgitab majandusliku languse mõju riskikapitali tegevusele. Lisa: Majandussurutise mõju erinevatele majandusharudele; Martin Kõdari märksõnad majanduslanguses toimetulekuks. Kommenteerivad Delfi nõukogu esimees Ville Jehe, Tallinna Konverentside omanik ja juht Ülla Mägi, Viisnurga finants- ja haldusdirektor Einar Pähkel ja Momentum Eesti juht Kristjan Kaleviste

Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2.

Science.gov (United States)

Bheda, Poonam; Swatkoski, Stephen; Fiedler, Katherine L; Boeke, Jef D; Cotter, Robert J; Wolberger, Cynthia

2012-04-17

Although the biological roles of many members of the sirtuin family of lysine deacetylases have been well characterized, a broader understanding of their role in biology is limited by the challenges in identifying new substrates. We present here an in vitro method that combines biotinylation and mass spectrometry (MS) to identify substrates deacetylated by sirtuins. The method permits labeling of deacetylated residues with amine-reactive biotin on the ε-nitrogen of lysine. The biotin can be utilized to purify the substrate and identify the deacetylated lysine by MS. The biotinyl-lysine method was used to compare deacetylation of chemically acetylated histones by the yeast sirtuins, Sir2 and Hst2. Intriguingly, Sir2 preferentially deacetylates histone H3 lysine 79 as compared to Hst2. Although acetylation of K79 was not previously reported in Saccharomyces cerevisiae, we demonstrate that a minor population of this residue is indeed acetylated in vivo and show that Sir2, and not Hst2, regulates the acetylation state of H3 lysine 79. The in vitro biotinyl-lysine method combined with chemical acetylation made it possible to identify this previously unknown, low-abundance histone acetyl modification in vivo. This method has further potential to identify novel sirtuin deacetylation substrates in whole cell extracts, enabling large-scale screens for new deacetylase substrates.

Dialogens kunstner : Dialog og performativitet hos Martin A. Hansen – med særligt henblik på hans ikke-fiktive forfatterskab

NARCIS (Netherlands)

Bay, A.

2017-01-01

This thesis is about the Danish writer Martin A. Hansen (1909-1955) and focusses on his essayistic works in which he acts as an engaged – but more importantly – also as a dialogical social critic. I have primarily looked into the way Martin A. Hansen (MAH) uses dialogue in his writings about modern

A stochastic SIRS epidemic model with infectious force under intervention strategies

Science.gov (United States)

Cai, Yongli; Kang, Yun; Banerjee, Malay; Wang, Weiming

2015-12-01

In this paper, we extend a classical SIRS epidemic model with the infectious forces under intervention strategies from a deterministic framework to a stochastic differential equation (SDE) one through introducing random fluctuations. The value of our study lies in two aspects. Mathematically, by using the Markov semigroups theory, we prove that the reproduction number R0S can be used to govern the stochastic dynamics of SDE model. If R0S 1, under mild extra conditions, it has an endemic stationary distribution which leads to the stochastical persistence of the disease. Epidemiologically, we find that random fluctuations can suppress disease outbreak, which can provide us some useful control strategies to regulate disease dynamics.

Sir Charles Bell (1774-1842) and his contributions to early neurosurgery.

Science.gov (United States)

Tubbs, R Shane; Riech, Sheryl; Verma, Ketan; Mortazavi, Martin M; Loukas, Marios; Benninger, Brion; Cohen-Gadol, Aaron A

2012-03-01

The renowned surgeon, neuroanatomist, and artist Sir Charles Bell not only impacted the lives of his peers through his creative endeavors and passion for art, but also sparked noteworthy breakthroughs in the field of neuroscience. His empathetic nature and zest for life enabled him to develop an early proclivity for patient care. As a result of his innovative findings regarding sensory and motor nerves and the anatomical makeup of the brain, he accepted some of the most prestigious awards and received an honorable reputation in society. Bell is recognized for his diligence, perseverance, and his remarkable contributions to surgery. The present review will explore his contributions to the discipline now known as neurosurgery.

Maurice Couturier. Nabokov ou la cruauté du désir.

Directory of Open Access Journals (Sweden)

René Alladaye

2006-04-01

Full Text Available La lecture peut avoir partie liée avec la transgression. Maurice Couturier en apporte la preuve dans son dernier ouvrage, Nabokov ou la cruauté du désir, en enfreignant l’un des plus célèbres interdits nabokoviens, celui de la lecture psychanalytique de son œuvre. On se souvient des préfaces des romans où l’auteur ne se fait jamais faute de décourager la moindre velléité freudienne et d’une réponse des plus tranchantes administrée dans le cadre d’un entretien : « Laissons les crédules et les ...

THEOLOGYOF DIALOGUE. MARTIN BUBER AND CHRISTIANITY

Directory of Open Access Journals (Sweden)

G. ZAVERSHINSKY

2011-06-01

Full Text Available Martin Buber is one of pioneers of the dialog method, which is to complete the standard subject-object approach in the humanities. It was he, who had shaped the classic form to this method and attempted to use it when developing relationship patterns between Judaism and Christianity. In the author’s view, Buber failed in this attempt, as it shows the study of his work «Zwei Glaubensweisen». It had happened because of Buber’s not quite «dialogical» views on person of Christ and lack of good acquaintance with all the complexity and diversity of the Christian thought. Buber could not interpret properly the St. Paul’s thought without considering hypostatic communication with God as it is presented in the orthodox theology. In spite of this the author believes that fruits of Buber’s labor in the dialogue philosophy still can be in many ways useful for Christian theology and practice

Critical Discourse Analysis of Martin Luther King's Speech in Socio-Political Perspective

Science.gov (United States)

Sipra, Muhammad Aslam; Rashid, Athar

2013-01-01

The article presents the Critical Discourse Analysis (CDA) of the first part of King Martin Luther's speech "When I Have a Dream" in socio-political context. The study investigates how it lies on the basis of application of Fairclough version of CDA in the first part of the text. Moreover, it explicates the terms like social, cultural…

Genes ycfR, sirA and yigG contribute to the surface attachment of Salmonella enterica Typhimurium and Saintpaul to fresh produce.

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Joelle K Salazar

Full Text Available Salmonella enterica is a frequent contaminant of minimally-processed fresh produce linked to major foodborne disease outbreaks. The molecular mechanisms underlying the association of this enteric pathogen with fresh produce remain largely unexplored. In our recent study, we showed that the expression of a putative stress regulatory gene, ycfR, was significantly induced in S. enterica upon exposure to chlorine treatment, a common industrial practice for washing and decontaminating fresh produce during minimal processing. Two additional genes, sirA involved in S. enterica biofilm formation and yigG of unknown function, were also found to be differentially regulated under chlorine stress. To further characterize the roles of ycfR, sirA, and yigG in S. enterica attachment and survival on fresh produce, we constructed in-frame deletions of all three genes in two different S. enterica serovars, Typhimurium and Saintpaul, which have been implicated in previous disease outbreaks linked to fresh produce. Bacterial attachment to glass and polystyrene microtiter plates, cell aggregation and hydrophobicity, chlorine resistance, and surface attachment to intact spinach leaf and grape tomato were compared among wild-type strains, single-gene deletion mutants, and their respective complementation mutants. The results showed that deletions of ycfR, sirA, and yigG reduced bacterial attachment to glass and polystyrene as well as fresh produce surface with or without chlorine treatment in both Typhimurium and Saintpaul. Deletion of ycfR in Typhimurium significantly reduced bacterial chlorine resistance and the attachment to the plant surfaces after chlorinated water washes. Deletions of ycfR in Typhimurium and yigG in Saintpaul resulted in significant increase in cell aggregation. Our findings suggest that ycfR, sirA, and yigG collectively contribute to S. enterica surface attachment and survival during post-harvest minimal processing of fresh produce.

Vulnerabilidade Natural do Solo de Silveira Martins-RS

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Franciele Francisca Marmentini Rovani

Full Text Available A análise ambiental, com base nos processos de morfogênese e pedogênese, possibilita informações importantes para a elaboração de políticas públicas visando o uso e ocupação da paisagem de maneira sustentável. Com isso, objetivou-se identificar os diferentes níveis de vulnerabilidade natural à perda de solo do município de Silveira Martins, RS. Foi elaborado um banco de dados espaciais em um ambiente de Sistemas de Informações Geográficas (SIG com auxílio do software Spring. O zoneamento da vulnerabilidade natural à perda de solo foi elaborado com base nas informações referentes à declividade, geomorfologia, geologia e solos de acordo com o grau de vulnerabilidade de cada informação, por meio da álgebra de mapas. Para o território municipal de Silveira Martins identificou-se a ocorrência de cinco classes. Destacam-se as unidades estáveis com predomínio dos processos formadores do solo (38,08% da área municipal, e as unidades moderadamente vulneráveis, prevalecendo os processos erosivos (53,67%. As áreas classificadas como moderadamente vulnerável e vulnerável (8,25%, correspondem a áreas com inclinações superiores a 25º e com formação geológica e geomorfológica menos estáveis. Nas unidades em que predominou a vulnerabilidade natural, sugere-se especial atenção em relação ao meio natural e aos agentes que o influenciam, visando boas práticas sociais associadas às políticas ambientais no processo de tomada de decisões econômicas, possibilitando a valorização e proteção do meio natural.

On a Kubo-Martin-Schwinger state of the Sine-Gordon system

International Nuclear Information System (INIS)

Peskov, N.V.

1986-01-01

This paper considers the Sine-Gordon equation on a finite interval as a Hamiltonian system. A Gaussian measure is defined on an extension of the phase space. It is shown that the partition funciton Z employed in the statistical mechanics of the solitons is an integral with respect to this measure. An algebra of observables is defined and on it a state is constructed which satisfies the Kubo-Martin-Schwinger condition

Tšehhid laovad võidusamba 250 kilostest klaasmoodulitest / Martin Chab ; interv. Toivo Tänavsuu

Index Scriptorium Estoniae

Chab, Martin

2008-01-01

Tšehhi firma Sans Souci projekteerib ja püstitab 15. oktoobriks 2008. a. Tallinnasse Harjumäele Vabadussõja võidusamba. Firma juht Martin Chab tutvustab monumendi materjali, konstruktsiooni, valgustust, paigaldamist. Firma Sans Souci teistest töödest

Rezension: Clans, Gilden und Gamefamilies – Soziale Prozesse in Computerspielgemeinschaften - von Geisler, Martin (2009

Directory of Open Access Journals (Sweden)

Karl H. Stingeder

2013-03-01

Full Text Available Computerspielegemeinschaften prägen den virtuellen Alltag in vielen Online-Spielen. Mehr noch: Online-Spiele werden häufig erst durch Gamefamilies richtig reizvoll und motivieren langfristig. Martin Geisler hat sich diesem medienpädagogischen Themenkomplex eingehend gewidmet.

Martin Marietta Energy Systems, Inc., Groundwater Program Management Plan

International Nuclear Information System (INIS)

Early, T.O.

1994-05-01

The purpose of the Martin Marietta Energy Systems, Inc., (Energy Systems) Groundwater Program Management Plan is to define the function, organizational structure (including associated matrix organizations), interfaces, roles and responsibilities, authority, and relationship to the Department of Energy for the Energy Systems Groundwater Program Office (GWPO). GWPO is charged with the responsibility of coordinating all components of the groundwater program for Energy Systems. This mandate includes activities at the three Oak Ridge facilities [Oak Ridge National Laboratory, the Oak Ridge Y-12 Plant, and the Oak Ridge K-25 Site], as well as the Paducah and Portsmouth Gaseous Diffusion Plants

Martin Marietta Energy Systems, Inc., Groundwater Program Management Plan

Energy Technology Data Exchange (ETDEWEB)

Early, T.O.

1994-05-01

The purpose of the Martin Marietta Energy Systems, Inc., (Energy Systems) Groundwater Program Management Plan is to define the function, organizational structure (including associated matrix organizations), interfaces, roles and responsibilities, authority, and relationship to the Department of Energy for the Energy Systems Groundwater Program Office (GWPO). GWPO is charged with the responsibility of coordinating all components of the groundwater program for Energy Systems. This mandate includes activities at the three Oak Ridge facilities [Oak Ridge National Laboratory, the Oak Ridge Y-12 Plant, and the Oak Ridge K-25 Site], as well as the Paducah and Portsmouth Gaseous Diffusion Plants.

Martin Luther King, Jr., General Hospital and community involvement.

Science.gov (United States)

Humphrey, M M

1973-07-01

Community involvement is not just one facet of the new Martin Luther King, Jr., General Hospital's existence. It is the mainstream from which all other activities flow. In addition to meeting the conventional needs of a conventional hospital staff with the core collection of texts and journals, this library goes one step further. It acts as a resource for its community health workers, dietitians, and nurses in their various outreach programs. It serves as a stimulus for the high school or community college student who may be curious about a health career. It also finds time to provide reading material for its patients.

Global stability of an SIR model with differential infectivity on complex networks

Science.gov (United States)

Yuan, Xinpeng; Wang, Fang; Xue, Yakui; Liu, Maoxing

2018-06-01

In this paper, an SIR model with birth and death on complex networks is analyzed, where infected individuals are divided into m groups according to their infection and contact between human is treated as a scale-free social network. We obtain the basic reproduction number R0 as well as the effects of various immunization schemes. The results indicate that the disease-free equilibrium is locally and globally asymptotically stable in some conditions, otherwise disease-free equilibrium is unstable and exists an unique endemic equilibrium that is globally asymptotically stable. Our theoretical results are confirmed by numerical simulations and a promising way for infectious diseases control is suggested.

[Sir Arthur Conan Doyle, Sherlock Holmes and infectious diseases].

Science.gov (United States)

Ledermann D, Walter

2010-10-01

Besides a pleasant author of best sellers, Sir Arthur Conan Doyle was a medical doctor, writing excellent short stories about the exercise of his profession in England. However, even he mentions The British Medical Journal and The Lancet in the Sherlock Holmes's stories, when in the plot introduces infectious diseases, Conan Doyle ignores important discoveries in the field of tetanus. Anyway, the appearing of infectious diseases in the adventures of the detective are rare: one mention of tetanus, another of leprosy and- the most analyzed in medical literature a case of murder by inoculation of bacteria, probably the agent of melioidosis. Also he makes his hero discovers the toxic actions of a medusa and a transplant of solid organ. Little for a physician and less for an author who also wrote science fiction: it seems that the history of the great medical discoveries at the end of nineteenth century and beginning of the twentieth has passed by his side.., and he just couldn't see it.

Mosaiigitükid vajavad uut moodi kokkupanekut / Martin Klöker ; intervjueerinud Katrin Kaugver

Index Scriptorium Estoniae

Klöker, Martin, 1966-

2012-01-01

Intervjuu kirjandus- ja kultuuriloolase Martin Klökeriga, kes viibis TLÜAR-i kutsel 2012. a märtsis Tallinnas ning pidas avaliku loengu "Ebatäielik pilt: trükitud raamat ja käsikiri kultuuride uurimises" ning kokkuvõte loengust

Martin Buber's Philosophy of Education and Its Implications for Adult Non-Formal Education

Science.gov (United States)

Guilherme, Alex; Morgan, W. John

2009-01-01

The Jewish philosopher and educator Martin Buber (1878-1965) is considered one of the twentieth century's greatest contributors to the philosophy of religion and is also recognized as the pre-eminent scholar of "Hasidism." He has also attracted considerable attention as a philosopher of education. However, most commentaries on this aspect of his…

Female House Martin Delichon urbica provisions chicks at nests in two separate subcolonies

NARCIS (Netherlands)

Piersma, Theunis

2008-01-01

An individually colour-ringed House Martin Delichon urbica, molecularly confirmed to be a female, after attending a first brood in early July 2007, became engaged with two second broods at the same time, one with the original mate of the first brood. The two nests were at opposite sides of the same

Different strategies of osmoadaptation in the closely related marine myxobacteria Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1.

Science.gov (United States)

Amiri Moghaddam, Jamshid; Boehringer, Nils; Burdziak, Amal; Kunte, Hans-Jörg; Galinski, Erwin A; Schäberle, Till F

2016-02-03

Only a few myxobacteria are known to date which are classified as marine due to their salt-dependency. In this study, the salt tolerance mechanism of these bacteria was investigated. Therefore, a growth medium was designed, in which the mutated Escherichia coli strain BKA13 served as sole food source for the predatory, heterotrophic myxobacteria. This enabled measurement of the osmolytes without any background and revealed that the closely related strains Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1 developed different strategies to handle salt stress. P. pacifica SIR-1, which was grown between 1-4 % NaCl, relies solely on the accumulation of amino acids, while E. salina SWB007, which was grown between 0.5-3 % NaCl, employs, beside betaine, hydroxyectoine as the major compatible solute. In accordance with this analysis, only in the latter strain a gene locus was identified which codes for genes corresponding to the biosynthesis of betaine, ectoine, and hydroxyectoine.

Deforestation and Secondary Growth in Rondonia, Brazil from SIR-C SAR and Landsat.SPOT data

Science.gov (United States)

Rignot, Eric; Salas, William A.; Skole, David L.

1996-01-01

Covers problems with existing data collected with high-resolution optical sensors. They say active microwave sensors could complement other sensors in getting through things like cloud cover. They analyzed SIR-C data in combination with Landsat TM data, a 9-year time series of SPOT XS data, and a preliminary field survey. They report findings and draw conclusions, including that SARs operating at long radar wavelengths, with both like and cross-polarizations, are needed for tropical deforestation studies.

Increased extracellular heat shock protein 90α in severe sepsis and SIRS associated with multiple organ failure and related to acute inflammatory-metabolic stress response in children.

Science.gov (United States)

Fitrolaki, Michaela-Diana; Dimitriou, Helen; Venihaki, Maria; Katrinaki, Marianna; Ilia, Stavroula; Briassoulis, George

2016-08-01

Mammalian heat-shock-protein (HSP) 90α rapidly responses to environmental insults. We examined the hypothesis that not only serum HSP72 but also HSP90α is increased in the systemic inflammatory response syndrome (SIRS), severe-sepsis (SS), and/or sepsis (S) compared to healthy children (H); we assessed HSP90α relation to (a) multiple organ system failure (MOSF) and (b) inflammatory-metabolic response and severity of illness.A total of 65 children with S, SS, or SIRS and 25 H were included. ELISA was used to evaluate extracellular HSP90α and HSP72, chemiluminescence interleukins (ILs), flow-cytometry neutrophil-CD64 (nCD64)-expression.HSP90α, along with HSP72, were dramatically increased among MOSF patients. Patients in septic groups and SIRS had elevated HSP90α compared to H (P stress, fever, outcome endpoints, and predicted mortality and inversely related to the low-LDL/low-HDL stress metabolic pattern.

Sir Francis Joseph Campbell and His Family: The First Family in Professional Services for People Who Are Blind or Visually Impaired

Science.gov (United States)

Welsh, Richard L.

2008-01-01

The author discusses the pivotal roles of Sir Francis Campbell (1832-1914) and members of his family, especially his son Charles Campbell, in the evolution of the blindness field to a professional and reason-based service.

Jean-Martin Charcot's Role in the 19th Century Study of Music Aphasia

Science.gov (United States)

Johnson, Julene K.; Lorch, Marjorie; Nicolas, Serge; Graziano, Amy

2013-01-01

Jean-Martin Charcot (1825-93) was a well-known French neurologist. Although he is widely recognized for his discovery of several neurological disorders and his research into aphasia, Charcot's ideas about how the brain processes music are less well known. Charcot discussed the music abilities of several patients in the context of his "Friday…

Religión y Paz en Martin Luther King Jr.

OpenAIRE

Mussio, Ria Stacy

2016-01-01

Esta tesis pretende mostrar el rol integral que la religión desempeñaba en la obtención de los derechos civiles para los afroamericanos y, también en el logro de la paz positiva. Martin Luther King Jr. y la mayoría de los manifestantes del movimiento eran cristianos, poniendo su fe en Dios, para el pleno disfrute de sus derechos humanos. King Jr., anclado en su fe, impulsó el avance de los derechos civiles, mediante la resistencia no violenta. El primer capítulo tiene como finalidad orientar ...

Obituary: Martin F. McCarthy (1923-2010)

Science.gov (United States)

Coyne, George; Rubin, Vera

2011-12-01

Martin F. McCarthy, S.J., astronomer at the Vatican Observatory from 1958 until his retirement in 1999, died peacefully on 5 February at the age of 86 years at the Jesuit Campion Health Center in Weston, Massachusetts where he had resided since his retirement. McCarthy received his doctorate in astronomy from Georgetown University, Washington, DC in 1951. The study of carbon stars, stars whose atmospheres contain more carbon than oxygen, was a major interest for McCarthy. Carbon stars were originally discovered and studied in the 1860s by Fr. Secchi, the eminent Jesuit astronomer. Interestingly, Fr. Secchi spent 1848-50 at Georgetown University in Washington, where Martin McCarthy would receive his PhD degree 101 years later. Upon completion of his seminary studies in theology, he carried out post-doctoral research at Warner and Swasey Observatory, Lick Observatory, the Dominion Astrophysical Observatory and Yerkes Observatory until he began his career at the Vatican Observatory where he served as a key figure in the Observatory's transition to the world of modern research. He also brought the Observatory onto the international stage through his collaborations in research at, among other institutes, Palomar Observatory, Lowell Observatory, Las Campanas Observatories, the Cerro Tololo Interamerican Observatory and the Carnegie Institute of Washington. He served on the Executive Council of the Italian Astronomical Society (1969-1971), was chair of the National Committee of the Vatican to the International Astronomical Union (IAU) from 1979 until his retirement and was President of IAU Commission 25 Stellar Photometry and Polarimetry (1976-1979). During his career he published more than 120 research papers. He was a natural teacher, who enjoyed explaining and talking science to students and visitors. Among his many contributions to the growth of the Vatican Observatory, he was responsible in 1986 for the beginning of the series of the Vatican Observatory Summer

Ut Pictura Poesis : dialéctica entre palabras e imagen en Sir William Sterling Maxwell

Directory of Open Access Journals (Sweden)

Hilary Macartney

2002-01-01

Full Text Available En el presente artículo se analiza la estrecha relación entre la historia del arte de Sir William Stirling Maxwell, su biblioteca y su colección artística. Este vínculo encierra la clave para la comprensión de su excepcional aportación a la historiografía del arte español. Sus diversas actividades, como historiador del arte, coleccionista de libros y cuadros, y director de ediciones privadas de libros raros, fueron todas manifestaciones de su gran fascinación por el paralelo entre la literatura y el arte, la palabra y la imagen. Tal relación se encuentra incluso en el esquema decorativo de su biblioteca.This article examines the remarkable unity between Sir William Stirling Maxwell's art history, his library and his art collection and argües that this relationship is the key to understanding his unique contribution to scholarship of Spanish art. In particular, it will be shown that his actlvities as an art historian, bibliophile, art collector and editor of prívate editions of rare books were all expressions of his fascination with the relationship between literature and art in general, and more specifically between word and image. Even the decorative scheme of his library emphasised this relationship.

A mixed SIR-SIS model to contain a virus spreading through networks with two degrees

Science.gov (United States)

Essouifi, Mohamed; Achahbar, Abdelfattah

Due to the fact that the “nodes” and “links” of real networks are heterogeneous, to model computer viruses prevalence throughout the Internet, we borrow the idea of the reduced scale free network which was introduced recently. The purpose of this paper is to extend the previous deterministic two subchains of Susceptible-Infected-Susceptible (SIS) model into a mixed Susceptible-Infected-Recovered and Susceptible-Infected-Susceptible (SIR-SIS) model to contain the computer virus spreading over networks with two degrees. Moreover, we develop its stochastic counterpart. Due to the high protection and security taken for hubs class, we suggest to treat it by using SIR epidemic model rather than the SIS one. The analytical study reveals that the proposed model admits a stable viral equilibrium. Thus, it is shown numerically that the mean dynamic behavior of the stochastic model is in agreement with the deterministic one. Unlike the infection densities i2 and i which both tend to a viral equilibrium for both approaches as in the previous study, i1 tends to the virus-free equilibrium. Furthermore, since a proportion of infectives are recovered, the global infection density i is minimized. Therefore, the permanent presence of viruses in the network due to the lower-degree nodes class. Many suggestions are put forward for containing viruses propagation and minimizing their damages.

Best Manufacturing Practices: Report of Survey Conducted at Lockheed Martin Tactical Aircraft Systems, Fort Worth, TX

National Research Council Canada - National Science Library

1995-01-01

.... This division of Lockheed Martin employs more than 11,900 personnel with a 1994 payroll of $677.76 million. Facilities encompass 602 acres with over seven million square feet of building space...

Filtering authentic sepsis arising in the ICU using administrative codes coupled to a SIRS screening protocol.

Science.gov (United States)

Sudduth, Christopher L; Overton, Elizabeth C; Lyu, Peter F; Rimawi, Ramzy H; Buchman, Timothy G

2017-06-01

Using administrative codes and minimal physiologic and laboratory data, we sought a high-specificity identification strategy for patients whose sepsis initially appeared during their ICU stay. We studied all patients discharged from an academic hospital between September 1, 2013 and October 31, 2014. Administrative codes and minimal physiologic and laboratory criteria were used to identify patients at high risk of developing the onset of sepsis in the ICU. Two clinicians then independently reviewed the patient record to verify that the screened-in patients appeared to become septic during their ICU admission. Clinical chart review verified sepsis in 437/466 ICU stays (93.8%). Of these 437 encounters, only 151 (34.6%) were admitted to the ICU with neither SIRS nor evidence of infection and therefore appeared to become septic during their ICU stay. Selected administrative codes coupled to SIRS criteria and applied to patients admitted to ICU can yield up to 94% authentic sepsis patients. However, only 1/3 of patients thus identified appeared to become septic during their ICU stay. Studies that depend on high-intensity monitoring for description of the time course of sepsis require clinician review and verification that sepsis initially appeared during the monitoring period. Copyright © 2017 Elsevier Inc. All rights reserved.

The marine Algal Vegetation of St. Martin, St. Eustatius and Saba (Netherlands Antilles)

NARCIS (Netherlands)

Vroman, M.

1968-01-01

Along the coast of St. Martin, St. Eustatius and Saba the rocks above sea-level often show a number of differently coloured zones. This is clearly visible when the coast over a larger distance is formed by one type of rock, as for instance on Saba. In many places a light-coloured belt is seen above

Kolm vaadet Tallinna vanalinnale / Villem Tomiste, Martin Aunin, Robert Treufeldt ; intervjueerinud Ingrid Ruudi

Index Scriptorium Estoniae

Tomiste, Villem, 1975-

2009-01-01

Tallinna vanalinna ja kesklinna piiril asuv kvartal 57B, mis piirneb Aia, Vana-Viru, Inseneri tänava ja Mere Puiesteega, ajendas vanalinna hoonestuspõhimõtete ja tulevikulahenduste üle arutama arhitekte Villem Tomistet, Martin Auninit ning arhitektuuriajaloolast, ICOMOSi Eesti komitee esimeest Robert Treufeldti. Pikemalt korterelamust Aia 4/Vana-Viru 13, Aia 6 ja 8 detailplaneeringu eskiisist

Threshold Dynamics in Stochastic SIRS Epidemic Models with Nonlinear Incidence and Vaccination

Directory of Open Access Journals (Sweden)

Lei Wang

2017-01-01

Full Text Available In this paper, the dynamical behaviors for a stochastic SIRS epidemic model with nonlinear incidence and vaccination are investigated. In the models, the disease transmission coefficient and the removal rates are all affected by noise. Some new basic properties of the models are found. Applying these properties, we establish a series of new threshold conditions on the stochastically exponential extinction, stochastic persistence, and permanence in the mean of the disease with probability one for the models. Furthermore, we obtain a sufficient condition on the existence of unique stationary distribution for the model. Finally, a series of numerical examples are introduced to illustrate our main theoretical results and some conjectures are further proposed.

Tõeline modernist Allan Murdmaa / Toivo Tammik, Arne Maasik, Martin Pedanik, Heie Treier ; intervjueerinud Reet Varblane

Index Scriptorium Estoniae

2009-01-01

Allan Murdmaast (4. 08. 1934-15. 11. 2009) vestlevad 18. novembril Arhitektuuri- ja Disainigaleriis avatud Allan Murdmaa näituse ja raamatu "Monumentaalne : Allan Murdmaa" autorid arhitektid Toivo Tammik ja Arne Maasik ning graafiline disainer Martin Pedanik, lisaks kunstiteadlane Heie Treier

Pastoors naar de PFA: nieuwe impuls voor samenwerking met de wetenschap (interview met Martin Pastoors)

NARCIS (Netherlands)

Pastoors, M.A.

2014-01-01

De Pelagic Freezer-trawler Association (PFA) heeft visserijonderzoeler Martin Pastoors aangenomen als 'Chief Science Officer'. De afgelopen tien jaar is de PFA zich steeds meer bezig gaan houden met wetenschappelijk onderzoek. Bijvoorbeeld door het ontwikkelen van nieuwe manieren om data te

Geolocator Data Reveal the Migration Route and Wintering Location of a Caribbean Martin (Progne dominicensis)

NARCIS (Netherlands)

Perlut, N.G.; Klak, T.C.; Rakhimberdiev, E.

2017-01-01

Caribbean Martins (Progne dominicensis)are common breeders on most Caribbean islands, where theyregularly roost and nest in urban areas from Februarythrough August. However, from September through January,the basic ecology of this species—its migration andwintering locations—are largely unknown. In

On Kubo-Martin-Schwinger states of classical dynamical systems with the infinite-dimensional phase space

International Nuclear Information System (INIS)

Arsen'ev, A.A.

1979-01-01

Example of a classical dynamical system with the infinite-dimensional phase space, satisfying the analogue of the Kubo-Martin-Schwinger conditions for classical dynamics, is constructed explicitly. Connection between the system constructed and the Fock space dynamics is pointed out

Martin Luther King, Jr.: A Lesson with Interdisciplinary Connections for Middle-Level Music Students.

Science.gov (United States)

Early, Mary Frances; Terry, Cynthia

This lesson begins with a very brief biography of Martin Luther King, Jr. The lesson identifies its educational objectives; addresses National Standards for Music Education; lists materials needed; details six step-by-step classroom procedures for lesson implementation; and provides curriculum connections for language arts, visual art, physical…

On pulse vaccine strategy in a periodic stochastic SIR epidemic model

International Nuclear Information System (INIS)

Wang, Fengyan; Wang, Xiaoyi; Zhang, Shuwen; Ding, Changming

2014-01-01

A periodic stochastic SIR epidemic model with pulse vaccination is studied. The system has global positive solutions and under some conditions it admits a unique positive periodic disease-free solution, which is globally exponentially stable in mean square. The mathematical expectation and variance of the positive periodic solution are obtained. Two threshold parameters R 1 and R 2 (R 1 >R 2 ) are identified; if R 1 <1, the susceptible will be persistent in the mean and the disease will go to extinction; if R 2 >1, the susceptible and the disease will be weakly persistent in the mean. We show that by repeatedly vaccinating the susceptible population in series of pulses, it is possible to eradicate the infective from the entire model population in the random environment

Granular statistical mechanics - Building on the legacy of Sir Sam Edwards

Science.gov (United States)

Blumenfeld, Raphael

When Sir Sam Edwards laid down the foundations for the statistical mechanics of jammed granular materials he opened a new field in soft condensed matter and many followed. In this presentation we review briefly the Edwards formalism and some of its less discussed consequences. We point out that the formalism is useful for other classes of systems - cellular and porous materials. A certain shortcoming of the original formalism is then discussed and a modification to overcome it is proposed. Finally, a derivation of an equation of state with the new formalism is presented; the equation of state is analogous to the PVT relation for thermal gases, relating the volume, the boundary stress and measures of the structural and stress fluctuations. NUDT, Changsha, China, Imperial College London, UK, Cambridge University, UK.

Development of Immunopathobiogenesis on SIRS-Sepsis

Directory of Open Access Journals (Sweden)

A Guntur Hermawan

2009-04-01

Full Text Available Over the past decade, sepsis has been diagnosed according to consensus guidelines established in 1991 as an infection in addition to the symptoms of systemic inflammatory response syndrome (SIRS. In addition to the previous criteria, the 2001 conference added several new diagnostic criteria for sepsis. Of particular interest was the inclusion of the biomarkers procalcitonin (PCT and C-reactive protein (CRP, despite the overall conclusion that it was premature to use biomarkers for sepsis diagnosis. The primary recommendation of the panel was the implementation of the Predisposition, insult Infection, Response, and Organ dysfunction (PIRO.The immune system has traditionally been devided into innate and adaptive components, each of which has a different role and function in defending the host against infectious agents. Stimulation of different TLRs induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also increasing evidence supports an additional critical role for TLRs in orchestrating the development of adaptive immune responses. The superantigens are able to induce toxic shock syndrome and can sometimes cause multiple organ failure via adaptive immune system. The superantigenic activity of the bacterial exotoxins can be attributed to their ability to cross-link major histocompatibility complex class II molecules on antigen-presenting cells outside the peptide groove with T-cell receptors to form a trimolecular complex. This trimolecular interaction leads to uncontrolled release of a number of proinflammatory cytokines. Proinflammatory cytokines especially IFN-γ and TNF-α, the key cytokines causing toxic shock syndrome. KEYWORDS: sepsis, innate immunity, adaptive.

Vabaühendused on olemas ja aktiivsed / Barbara Lehtna ; kommenteerivad Martin Mölder, Urmo Kübar

Index Scriptorium Estoniae

Lehtna, Barbara

2011-01-01

Kodanikeühenduste võimalusest poliitikas kaasa rääkida. Eesti Üliõpilaskondade Liidu valimisplatvormi 2011 kommenteerib TÜ politoloog Martin Mölder ja soovitusi platvormi koostamiseks annab EMSLi juhataja Urmo Kübar

First Student Project at the University of Tennessee at Martin Observatory

Science.gov (United States)

Crews, Lionel J.; Turner, K.; Wesner, P.

2011-05-01

The University of Tennessee at Martin has recently completed the construction and setup of an observatory. The dome houses a 16" Meade telescope with SBIG STL-11000M CCD. For its first project, observations of the Delta Scuti type variable SZ Lynx were taken in March and analyzed using MiraPRO. A simple ephemeris calculation was done, and compared to previous results. This project was done under the University Scholars program, a four year scholarship program which includes a faculty-mentored research project.

MARTINS: A foam/film flow model for molten material relocation in HWRs with U-Al-fueled multi-tube assemblies

International Nuclear Information System (INIS)

Kalimullah.

1994-01-01

Some special purpose heavy-water reactors (EM) are made of assemblies consisting of a number of coaxial aluminum-clad U-Al alloy fuel tubes and an outer Al sleeve surrounding the fuel tubes. The heavy water coolant flows in the annular gaps between the circular tubes. Analysis of severe accidents in such reactors requires a model for predicting the behavior of the fuel tubes as they melt and disrupt. This paper describes a detailed, mechanistic model for fuel tube heatup, melting, freezing, and molten material relocation, called MARTINS (Melting and Relocation of Tubes in Nuclear subassembly). The paper presents the modeling of the phenomena in MARTINS, and an application of the model to analysis of a reactivity insertion accident. Some models are being developed to compute gradual downward relocation of molten material at decay-heat power levels via candling along intact tubes, neglecting coolant vapor hydrodynamic forces on molten material. These models are inadequate for high power accident sequences involving significant hydrodynamic forces. These forces are included in MARTINS

Photographic Standards for Patients With Facial Palsy and Recommendations by Members of the Sir Charles Bell Society.

Science.gov (United States)

Santosa, Katherine B; Fattah, Adel; Gavilán, Javier; Hadlock, Tessa A; Snyder-Warwick, Alison K

2017-07-01

There is no widely accepted assessment tool or common language used by clinicians caring for patients with facial palsy, making exchange of information challenging. Standardized photography may represent such a language and is imperative for precise exchange of information and comparison of outcomes in this special patient population. To review the literature to evaluate the use of facial photography in the management of patients with facial palsy and to examine the use of photography in documenting facial nerve function among members of the Sir Charles Bell Society-a group of medical professionals dedicated to care of patients with facial palsy. A literature search was performed to review photographic standards in patients with facial palsy. In addition, a cross-sectional survey of members of the Sir Charles Bell Society was conducted to examine use of medical photography in documenting facial nerve function. The literature search and analysis was performed in August and September 2015, and the survey was conducted in August and September 2013. The literature review searched EMBASE, CINAHL, and MEDLINE databases from inception of each database through September 2015. Additional studies were identified by scanning references from relevant studies. Only English-language articles were eligible for inclusion. Articles that discussed patients with facial palsy and outlined photographic guidelines for this patient population were included in the study. The survey was disseminated to the Sir Charles Bell Society members in electronic form. It consisted of 10 questions related to facial grading scales, patient-reported outcome measures, other psychological assessment tools, and photographic and videographic recordings. In total, 393 articles were identified in the literature search, 7 of which fit the inclusion criteria. Six of the 7 articles discussed or proposed views specific to patients with facial palsy. However, none of the articles specifically focused on

Anastomosis Martin-Gruber: Aspectos anatómicos y electrofisiológicos Martin-Gruber Anastomosis: Anatomical and electrophysiological issues

Directory of Open Access Journals (Sweden)

Esperanza Herrera

2009-08-01

Full Text Available La anastomosis de Martin Gruber (AMG es una de las variaciones anatómicas más frecuentes que consiste en la contribución de axones motores desde el nervio mediano hacia el ulnar en el antebrazo. Factores filogenéticos y genéticos se asocian con la aparición de la AMG. Entre tanto, otros factores como género, raza o lateralidad no parecen tener importancia en la aparición de la rama comunicante. Las clasificaciones de la AMG han sido establecidas según los hallazgos anatómicos, electrofisiológicos e histológicos y también según el lugar de origen y destino de la anastomosis. El objetivo de este artículo es revisar los factores asociados a la presencia de la AMG, así como las descripciones y clasificaciones anatómicas y electrofisiológicas. Esta revisión aporta información relevante para el reconocimiento de los patrones clásico y variante de inervación de la musculatura intrínseca de la mano. Dicho reconocimiento permite diagnosticar e intervenir apropiadamente las alteraciones de los nervios periféricos de la extremidad superior. Salud UIS 2009; 41: 157-168The Martin Gruber Anastomosis (MGA is one of the most common anatomical variants of the upper limb, which consists of motor axons crossing through the forearm from the median nerve to the ulnar nerve. Phylogenetic and hereditary factors have been associated whit the MGA. However, gender, race, or laterality, do not seem to have importance in the appearance of the communicating branch. The MGA has been categorized according to findings in anatomy, electrophysiology and histology, in relation to the source and destination of the communicating branch. The aim of this article is to review the factors related to the presence of MGA, as well as the descriptions and classifications according to anatomy and electrophysiology. This revision contributes with important information relevant to the recognition of differences between the classic pattern and the variant pattern of the

Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1.

Science.gov (United States)

Zhao, Xuan; Lu, Lulu; Qi, Yonghao; Li, Miao; Zhou, Lijun

2017-10-01

The naturally occurring anthraquinone emodin has been serving primarily as an anti-bacterial and anti-inflammatory agent. However, little is known about its potential on anti-aging. This investigation examined the effect of emodin on lifespan and focused on its physiological molecular mechanisms in vivo. Using Caenorhabditis elegans (C. elegans) as an animal model, we found emodin could extend lifespan of worms and improve their antioxidant capacity. Our mechanistic studies revealed that emodin might function via insulin/IGF-1 signaling (IIS) pathway involving, specifically the core transcription factor DAF-16. Quantitative RT-PCR results illustrated that emodin up-regulated transcription of DAF-16 target genes which express antioxidants to promote antioxidant capacity and lifespan of worms. In addition, attenuated effect in sir-2.1 mutants suggests that emodin likely functioned in a SIR-2.1-dependent manner. Our study uncovers a novel role of emodin in prolonging lifespan and supports the understanding of emodin being a beneficial dietary supplement.

Kulinaarne palverännak piki Telliskivi tänavat / Martin Hanson, Ines Haak

Index Scriptorium Estoniae

Hanson, Martin, 1984-

2013-01-01

Toidukriitik Martin Hanson ja sisearhitekt Ines Haak Tallinna Telliskivi tänavat palistavatest söögipaikadest: restoran Kolm Sibulat (sisearhitektuur: Aivar Mühlbach, omanikud, 2012-2013), bistroo Kukeke (Anni Arro, Riina Eerik, 2011-2012), kohvik Reval (Ville Lausmäe, Kadi Karmann, Peeter Klaas, 2013), restoran F-Hoone (Ville Jehe, Steve Heinlo, 2010), baar Pudel (Raul Tiitus, Tarmo Piirmets, 2012-2013)

Eesti Disaini muna BRUNO said Martin Pärn ja Annike Laigo / Urve Eslas

Index Scriptorium Estoniae

Eslas, Urve

2006-01-01

Eesti Disainerite Liidu auhinnad parima tootedisaini ja parima disainiprojekti eest pälvisid Martin Pärn büroomööbli seeria "Krog" eest ning Annike Laigo isehelenduva vaiba "Jaaniuss" eest. Samal teemal ka lk. 1 "Büroomööbel ja helendav vaip võitsid disaini-BRUNO". Eesti Disaini auhinna nominentide näitus on avatud Disaini- ja Arhitektuurigaleriis

Actions for the environmental adequateness and emissions control at the Martin del Corral power plant-Termozipa; Obras de adecuacion ambiental y control de emisiones para la central termoelectrica Martin del Corral - Termozipa

Energy Technology Data Exchange (ETDEWEB)

Arevalo Osorio, Luis [Empresa de Energia de Bogota, Bogota (Colombia)

1997-12-31

In this paper the general data on the Martin del Corral-Termozipa, of Colombia, fossil fueled power plant are exposed. The results of a study to determine the environmental impact originated in the influence zone of this Power Plant are presented, particularly on the Bogota River. The study was framed into the environmental policy driven by the Colombian sector. Different solutions addressed to the optimization of the handling, capacity and control of the emissions and counteract the pollution possibilities of the Bogota River are described [Espanol] En esta ponencia se exponen datos generales de la central termoelectrica Martin del Corral - Termozipa-, de Colombia. Se presentan los resultados de un estudio para determinar el impacto ambiental ocasionado en la zona de influencia de esta central, y en particular sobre el rio Bogota. El estudio se enmarco dentro de la politica ambiental impulsada por el sector colombiano. Se describen diversas soluciones encaminadas a optimizar el manejo, capacidad y control de las emisiones y contrarrestar las posibilidades de contaminacion del rio Bogota

Actions for the environmental adequateness and emissions control at the Martin del Corral power plant-Termozipa; Obras de adecuacion ambiental y control de emisiones para la central termoelectrica Martin del Corral - Termozipa

Energy Technology Data Exchange (ETDEWEB)

Arevalo Osorio, Luis [Empresa de Energia de Bogota, Bogota (Colombia)

1996-12-31

In this paper the general data on the Martin del Corral-Termozipa, of Colombia, fossil fueled power plant are exposed. The results of a study to determine the environmental impact originated in the influence zone of this Power Plant are presented, particularly on the Bogota River. The study was framed into the environmental policy driven by the Colombian sector. Different solutions addressed to the optimization of the handling, capacity and control of the emissions and counteract the pollution possibilities of the Bogota River are described [Espanol] En esta ponencia se exponen datos generales de la central termoelectrica Martin del Corral - Termozipa-, de Colombia. Se presentan los resultados de un estudio para determinar el impacto ambiental ocasionado en la zona de influencia de esta central, y en particular sobre el rio Bogota. El estudio se enmarco dentro de la politica ambiental impulsada por el sector colombiano. Se describen diversas soluciones encaminadas a optimizar el manejo, capacidad y control de las emisiones y contrarrestar las posibilidades de contaminacion del rio Bogota

Martine Joly, L'image et son interprétation

OpenAIRE

Thiéblemont-Dollet, Sylvie

2013-01-01

À partir de différents travaux menés sur plusieurs années, Martine Joly propose un parcours en quatre parties pour tenter de répondre à la vaste question de l'interprétation de l'image. Dès l'introduction, elle rappelle que s'il y a différents types d'images, il y a inévitablement plusieurs types d'interprétation, mais que, néanmoins, l'interprétation d'une œuvre n'est pas pour autant inextensible et comporte des limites et des règles de fonctionnement. L'idée majeure de cette étude est de te...

Spontaneous Transient Lateral Thoracic Lung Herniation Resulting in Systemic Inflammatory Response Syndrome (SIRS and Subsequent Contralateral Lung Injury

Directory of Open Access Journals (Sweden)

Antony Kaliyadan

2011-01-01

Full Text Available Lung herniation is a relatively rare clinical entity that is most commonly either congenital or acquired traumatically. We describe a case of spontaneous lung herniation secondary to acute cough in an obese male smoker complicated by contralateral acute lung injury and systemic inflammatory response syndrome (SIRS. Mechanisms of lung herniation, classification, diagnosis, and management will be discussed.

Resenha do curta-metragem “Tapete Verde” (2014 de Angelo Martins

Directory of Open Access Journals (Sweden)

Diego Ramos do Nascimento

2017-09-01

Full Text Available Trata da resenha do filme “Tapete Verde” produzido e dirigido Angelo Martins. Lançado em 2014, o diretor foca-se em relatar as experiências e as escolhas de 3 jovens na realização do sonho de se tornar jogador de futebol. Por seu caráter de curta-metragem, a obra destina-se a um restrito público, mas ganha destaque quando desbrava as realidades encontradas e contadas pelos aspirantes a jogadores e seus respectivos pais.

Newton's gift how Sir Isaac Newton unlocked the system of the world

CERN Document Server

Berlinski, David

2000-01-01

Sir Isaac Newton, creator of the first and perhaps most important scientific theory, is a giant of the scientific era. Despite this, he has remained inaccessible to most modern readers, indisputably great but undeniably remote. In this witty, engaging, and often moving examination of Newton's life, David Berlinski recovers the man behind the mathematical breakthroughs. The story carries the reader from Newton's unremarkable childhood to his awkward undergraduate days at Cambridge through the astonishing year in which, working alone, he laid the foundation for his system of the world, his Principia Mathematica, and to the subsequent monumental feuds that poisoned his soul and wearied his supporters. An edifying appreciation of Newton's greatest accomplishment, Newton's Gift is also a touching celebration of a transcendent man.

Dynamics analysis of SIR epidemic model with correlation coefficients and clustering coefficient in networks.

Science.gov (United States)

Zhang, Juping; Yang, Chan; Jin, Zhen; Li, Jia

2018-07-14

In this paper, the correlation coefficients between nodes in states are used as dynamic variables, and we construct SIR epidemic dynamic models with correlation coefficients by using the pair approximation method in static networks and dynamic networks, respectively. Considering the clustering coefficient of the network, we analytically investigate the existence and the local asymptotic stability of each equilibrium of these models and derive threshold values for the prevalence of diseases. Additionally, we obtain two equivalent epidemic thresholds in dynamic networks, which are compared with the results of the mean field equations. Copyright © 2018 Elsevier Ltd. All rights reserved.

Optimizing Real-Time Vaccine Allocation in a Stochastic SIR Model.

Directory of Open Access Journals (Sweden)

Chantal Nguyen

Full Text Available Real-time vaccination following an outbreak can effectively mitigate the damage caused by an infectious disease. However, in many cases, available resources are insufficient to vaccinate the entire at-risk population, logistics result in delayed vaccine deployment, and the interaction between members of different cities facilitates a wide spatial spread of infection. Limited vaccine, time delays, and interaction (or coupling of cities lead to tradeoffs that impact the overall magnitude of the epidemic. These tradeoffs mandate investigation of optimal strategies that minimize the severity of the epidemic by prioritizing allocation of vaccine to specific subpopulations. We use an SIR model to describe the disease dynamics of an epidemic which breaks out in one city and spreads to another. We solve a master equation to determine the resulting probability distribution of the final epidemic size. We then identify tradeoffs between vaccine, time delay, and coupling, and we determine the optimal vaccination protocols resulting from these tradeoffs.

Racism and the older voter? Arizona's rejection of a paid holiday to honor Martin Luther King.

Science.gov (United States)

Kastenbaum, R

1991-01-01

Two propositions that would have established a paid Martin Luther King holiday were defeated in Arizona's statewide elections of November 6, 1990. Communities and counties with high proportions of senior adult voters cast proportionately more votes against these propositions. Was this an example of racism among the primarily anglo senior adult voters of Arizona? Three models were proposed to account for the general pattern of election-related behavior as well as the vote itself: 1) proactive racist, 2) pragmatic self-interest, and 3) fortress mentality. It was suggested that proactive racism and pragmatic self-interest accounted for less of the opposition to a paid holiday honoring Martin Luther King than did a fortress mentality that has developed through a combination of circumstances. Attention is also given to the larger question of senior adults as perpetrators as well as victims of bigotry.

DOSEXPRT: A bioassay dosimetry code for Martin Marietta Energy Systems, Inc.

Energy Technology Data Exchange (ETDEWEB)

Ward, R.C.; Eckerman, K.F.

1992-04-01

The bioassay code DOSEXPRT was developed for Martin Marietta Energy Systems, Inc., to provide compliance with Department of Energy (DOE) Order 5480, Chapter 11. DOSEXPRT computes the intake of a radionuclide in any year (considering both acute and chronic intakes) from in vivo measurements of the retained activity and/or measurements of the activity in excreta. The committed effective and organ doses for the intake are computed as well as the effective and organ doses expected to be received in each calendar year out to 50 years beyond the year of intake. The bioassay records used as input for DOSEXPRT are extracted from the Martin Marietta Energy Systems Occupational Health Information System (OHIS). DOSEXPRT implements a set of algorithms with parameters governing the translocation, retention, and excretion of the nuclide contained in data files specific to the nuclide. These files also contain dose-per-unit-intake coefficients used to compute the committed dose equivalent for the intakes in the year. Annual organ and effective doses are computed using additional dose-rate files that contain data on the dose rate at various times following a unit intake. If measurements are presented for more than one assay for a given nuclide, DOSEXPRT estimates the intake by applying weights assigned in the nuclide file for each assay. DOSEXPRT is accessed off the OHIS MENU No. 4 and designed to be run as a batch processor, but can also be run interactively for testing purposes.

DOSEXPRT: A bioassay dosimetry code for Martin Marietta Energy Systems, Inc

Energy Technology Data Exchange (ETDEWEB)

Ward, R.C.; Eckerman, K.F.

1992-04-01

The bioassay code DOSEXPRT was developed for Martin Marietta Energy Systems, Inc., to provide compliance with Department of Energy (DOE) Order 5480, Chapter 11. DOSEXPRT computes the intake of a radionuclide in any year (considering both acute and chronic intakes) from in vivo measurements of the retained activity and/or measurements of the activity in excreta. The committed effective and organ doses for the intake are computed as well as the effective and organ doses expected to be received in each calendar year out to 50 years beyond the year of intake. The bioassay records used as input for DOSEXPRT are extracted from the Martin Marietta Energy Systems Occupational Health Information System (OHIS). DOSEXPRT implements a set of algorithms with parameters governing the translocation, retention, and excretion of the nuclide contained in data files specific to the nuclide. These files also contain dose-per-unit-intake coefficients used to compute the committed dose equivalent for the intakes in the year. Annual organ and effective doses are computed using additional dose-rate files that contain data on the dose rate at various times following a unit intake. If measurements are presented for more than one assay for a given nuclide, DOSEXPRT estimates the intake by applying weights assigned in the nuclide file for each assay. DOSEXPRT is accessed off the OHIS MENU No. 4 and designed to be run as a batch processor, but can also be run interactively for testing purposes.

Cicero's de legibus and Martin Luther King, Jr.’s Stride toward freedom

Directory of Open Access Journals (Sweden)

Boleslav s. Povšič

1979-12-01

Full Text Available He who reads carefully Cicero'sDe Legibus and Martin Luther King, Jr.'s Stride Toward Freedom is surprised to find, mutatis mutandis, on how many points these two great men agree. The historical circumstances are different, but the essential ideas are very similar. The purpose of this paper is to show on what precisely they agree and on what they differ.

Martin Parr in Mexico: Does Photographic Style Translate?

Directory of Open Access Journals (Sweden)

Timothy R. Gleason

2011-11-01

Full Text Available This study analyzes Martin Parr’s 2006 photobook, Mexico. Parr is a British documentary photographer best known for a direct photographic style that reflects upon “Englishness.”Mexico is his attempt to understand this foreign country via his camera. Mexico, as a research subject, is not a problem to solve but an opportunity to understand a photographer’s work. Parr’s Mexico photography (technique, photographic content, and interest in globalization, economics, and culture is compared to his previous work to explain how Parr uses fashion and icons to represent a culture or class. This article argues Parr’s primary subjects, heads/hats, food, and Christs, are photographed without excessive aesthetic pretensions so that the thrust of Parr’s message about globalization can be more evident:Mexico maintains many of its traditions and icons while adopting American brands.

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, SWINE WASTE ELECTRIC POWER AND HEAT PRODUCTION--MARTIN MACHINERY INTERNAL COMBUSTION ENGINE

Science.gov (United States)

Under EPA’s Environmental Technology Verification program, which provides objective and scientific third party analysis of new technology that can benefit the environment, a combined heat and power system designed by Martin Machinery was evaluated. This paper provides test result...

Address by the Baden-Wuerttemberg State Minister of Economics, Mr. Martin Herzog

International Nuclear Information System (INIS)

Herzog, M.

1986-01-01

In his address to the participants of the 7th Nuclear Inter Jura '85, the Baden-Wuerttemberg State Minister of Economics, Mr. Martin Herzog describes the situation of nuclear power in Baden-Wuerttemberg. He states that nuclear law has become a difficult topic, mainly because of the close connection between law and technology, and the international character of nuclear law. Therefore it is important to improve transparency of nuclear law on a national and an international level. (WG) [de

Has the Dream Been Fulfilled? Dr. Martin Luther King, Jr. & President Barack Hussein Obama

Science.gov (United States)

Robinson, Nichelle Boyd; Moore, Virginia J.; Williams-Black, Thea H.

2015-01-01

Equality for all was the dream of Dr. Martin Luther King, Jr. and he knowingly laid the foundation for and inspired the first African-American President of the United States of America, Barack Hussein Obama, who also had the dream of "Change" for America. These men exhibited how working together can make dreams become reality. For the…

Hudba pro století luterské reformace I. Martin Luther a duchovní hudba

Czech Academy of Sciences Publication Activity Database

Vytlačil, Lukáš

2017-01-01

Roč. 25, č. 9 (2017), s. 28-30 ISSN 1210-8081 Institutional support: RVO:68378076 Keywords : lutheran reformation * Martin Luther * sacred music * Johann Walter * Leonhard Lechner * music and liturgy * gospels * 16th century music history * renaissance music * evangelic church (sacred) music Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Performing arts studies ( Music ology, Theater science, Dramaturgy)

Kuus vaadet vastsele seadusele / Kaidi Urmet, Urmas Sutrop, Martin Hallik ... [jt.] ; intervjueerinud Mihkel Volt

Index Scriptorium Estoniae

2017-01-01

Mida arvavad 1. jaanuarist kehtima hakanud säilituseksemplari seadusest Eesti Kirjastuste Liidu tegevjuht Kaidi Urmet, Eesti Kirjandusmuuseumi direktor Urmas Sutrop, Tartu Ülikooli Raamatukogu direktor Martin Hallik, Tartu Ülikooli Raamatukogu kogude direktor Kristina Pai, Eesti Ajalehtede Liidu tegevdirektor Mart Raudsaar, Eesti Rahvusraamatukogu peadirektor Janne Andresoo ning Kultuuriministeeriumi raamatukogunõunik Ülle Talihärm

Shuttle imaging radar-A (SIR-A) data analysis. [geology of the Ozark Plateau of southern Missouri, land use in western Illinois, and vegetation types at Koonamore Station, Australia

Science.gov (United States)

Arvidson, R. E.

1983-01-01

The utility of shuttle imaging radar (SIR-A) data was evaluated in several geological and environmental contexts. For the Ozark Plateau of southern Missouri, SIR-A data were of little use in mapping structural features, because of generally uniform returns. For western Illinois, little was to be gained in terms of identifying land use categories by examining differences between overlapping passes. For southern Australia (Koonamore Station), information ion vegetation types that was not obtainable from LANDSAT MSS data alone was obtained. Specifically, high SIR-A returns in the Australian site were found to correlate with locations where shrubs increase surface roughness appreciably. The Australian study site results demonstrate the synergy of acquiring spectral reflectance and radar data over the same location and time. Such data are especially important in that region, since grazing animals have substantially altered and are continuing to alter the distribution of shrublands, grasslands, and soil exposures. Periodic, synoptic acquisition of MSS and SAR data would be of use in monitoring the dynamics of land-cover change in this environment.

Sir William Turner (1832-1916) - Lancastrian, anatomist and champion of the Victorian era.

Science.gov (United States)

Wessels, Quenton; Correia, Janine Carla; Taylor, Adam M

2016-11-01

Sir William Turner, a Lancastrian, was renowned as a scientist, anatomist and a great reformer of medical education. His students became anatomists at various international institutions, which consequently shaped the future of anatomy as a subject matter both in the United Kingdom and in South Africa. Although Turner's accomplishments have been documented, little is known about the details that determined his career path and the individuals that shaped his future. Here the authors aim to highlight some aspects of Turner's academic achievements and his personal life as well as how he crossed paths with other great minds of the Victorian era including Richard Owen, Charles Darwin, James Paget and Joseph Lister. © The Author(s) 2015.

Mille poolest on algav õppeaasta teile eriline? / Valmar Pantšenko, Martin Adamson, Maire Tamm, Eve Reisalu

Index Scriptorium Estoniae

2012-01-01

Küsimusele vastavad: Tartu Täiskasvanute Gümnaasiumi abiturient Valmar Pantšenko, Eesti meister motokrossis klassis Quad 100 Martin Adamson, Tamsalu Gümnaasiumi õppealajuhataja Maire Tamm ja Ristiku põhikooli õpetaja-metoodik Eve Reisalu

Performance comparison and selection criteria: an assessment for choosing the best flight detector for the SIR-2 NIR-spectrometer on Chandrayaan-1

Science.gov (United States)

Sitek, P.; Vilenius, E.; Mall, U.

2008-01-01

We describe the performance evaluation of a sample of InGaAs detectors from which the best unit had to be selected for the flight model of the SIR-2 NIR-spectrometer to be flown on the Chandrayaan-1 mission in 2008.

Novas espécies de Lamiinae (Cerambycidae neotropicais e transferência de Palpicrassus Galileo & Martins, 2007

Directory of Open Access Journals (Sweden)

Ubirajara R. Martins

2010-01-01

Full Text Available Novas espécies descritas do Brasil: Nesozineus amazonicus sp. nov. (Amazonas, Xenofrea diagonalis sp. nov. (Rondônia. Mauesia submetallica sp. nov. (Amazonas; da Bolívia: Psapharochrus nearnsi sp. nov. (Santa Cruz, Adetus basalis, sp. nov. (Santa Cruz, La Paz, Palpicrassus inexpectatus sp. nov. (Santa Cruz, Cyrtinus meridialis sp. nov. (Santa Cruz.. Do Panamá: Aerenea panamensis sp. nov. (Chiriqui. O gênero Palpicrassus Galileo & Martins, 2007, originalmente descrito em Pteropliini é transferido para Apomecynini.New species described from Brazil: Nesozineus amazonicus sp. nov. (Amazonas, Xenofrea diagonalis sp. nov. (Rondônia, Mauesia submetallica sp. nov. (Amazonas; from Bolivia: Psapharochrus nearnsi sp. nov. (Santa Cruz; Adetus basalis sp. nov. (Santa Cruz, La Paz, Palpicrassus inexpectatus sp. nov. (Santa Cruz, Cyrtinus meridialis sp. nov. (Santa Cruz., Aerenea panamensis sp. nov. from Panama (Chiriqui. The genus Palpicrassus Galileo & Martins, 2007, originally described in Pteropliini, is transferred to Apomecynini.

Muusikauudiseid maailmast / Nele-Eva Steinfeld

Index Scriptorium Estoniae

Steinfeld, Nele-Eva

2016-01-01

Lühisõnumeid maailmast: Suri Sir Peter Maxwell Davies. Pärijad ei võimalda juurdepääsu Verdi ja Puccini arhiividele. Eksklusiivne plaadileping Ksenija Sidorovale. Thomas Adès Bostoni sümfooniaorkestri kunstiline partner. Jätkuvad probleemid Inglise Rahvusooperis. Tõusev täht Karina Canellakis pälvis Georg Solti preemia. Suri biitlite mänedžer George Martin. Saksamaal taas üks orkester vähem. Milline kontserdisaal võimaldab võimsamat elamust. Beethoveni kiri

Sir John Adams: his legacy to the world of particle accelerators

CERN Document Server

Wilson, E J N

2011-01-01

John Adams acquired an unrivalled reputation for his leading part in designing and constructing the Proton Synchrotron (PS) in CERN’s early days. In 1968, and after several years heading a fusion laboratory in the UK, he came back to Geneva to pilot the Super Proton Synchrotron (SPS) project to approval and then to direct its construction. By the time of his early death in 1984 he had built the two flagship proton accelerators at CERN and, during the second of his terms as Director-General, he laid the groundwork for the proton–antiproton collider which led to the discovery of the intermediate vector boson. How did someone without any formal academic qualification achieve this? What was the magic behind his leadership? The speaker, who worked many years alongside him, will discuss these questions and speculate on how Sir John Adams might have viewed today’s CERN.

Squares of White Noise, SL(2,C) and Kubo - Martin -Schwinger States

OpenAIRE

Prokhorenko, D. V.

2007-01-01

We investigate the structure of Kubo - Martin - Schwinger (KMS) states on some extension of the universal enveloping algebra of SL(2,C}. We find that there exists a one-to-one correspondence between the set of all covariant KMS states on this algebra and the set of all probability measures d\\mu on the real half-line, which decrease faster than any inverse polynomial. This problem is connected to the problem of KMS states on square of white noise algebra.

Low sensitivity of qSOFA, SIRS criteria and sepsis definition to identify infected patients at risk of complication in the prehospital setting and at the emergency department triage.

Science.gov (United States)

Tusgul, Selin; Carron, Pierre-Nicolas; Yersin, Bertrand; Calandra, Thierry; Dami, Fabrice

2017-11-03

Sepsis is defined as life-threatening organ dysfunction caused by a host response to infection. The quick SOFA (qSOFA) score has been recently proposed as a new bedside clinical score to identify patients with suspected infection at risk of complication (intensive care unit (ICU) admission, in-hospital mortality). The aim of this study was to measure the sensitivity of the qSOFA score, SIRS criteria and sepsis definitions to identify the most serious sepsis cases in the prehospital setting and at the emergency department (ED) triage. We performed a retrospective study of all patients transported by emergency medical services (EMS) to the Lausanne University Hospital (CHUV) over twelve months. All patients with a suspected or proven infection after the ED workup were included. We retrospectively analysed the sensitivity of the qSOFA score (≥2 criteria), SIRS criteria (≥2 clinical criteria) and sepsis definition (SIRS criteria + one sign of organ dysfunction or hypoperfusion) in the pre-hospital setting and at the ED triage as predictors of ICU admission, ICU stay of ≥3 days and early (i.e. 48 h) mortality. No direct comparison between the three tools was attempted. Among 11,411 patients transported to the University hospital, 886 (7.8%) were included. In the pre-hospital setting, the sensitivity of qSOFA reached 36.3% for ICU admission, 17.4% for ICU stay of three days or more and 68.0% for 48 h mortality. The sensitivity of SIRS criteria reached 68.8% for ICU admission, 74.6% for ICU stay of three days or more and 64.0% for 48 h mortality. The sensitivity of sepsis definition did not reach 60% for any outcome. At ED triage, the sensitivity of qSOFA reached 31.2% for ICU admission, 30.5% for ICU stay of ≥3 days and 60.0% for mortality at 48 h. The sensitivity of SIRS criteria reached 58.8% for ICU admission, 57.6% for ICU stay of ≥3 days 80.0% for mortality at 48 h. The sensitivity of sepsis definition reached 60.0% for 48 h mortality. Incidence

A class of stochastic delayed SIR epidemic models with generalized nonlinear incidence rate and temporary immunity

Science.gov (United States)

Fan, Kuangang; Zhang, Yan; Gao, Shujing; Wei, Xiang

2017-09-01

A class of SIR epidemic model with generalized nonlinear incidence rate is presented in this paper. Temporary immunity and stochastic perturbation are also considered. The existence and uniqueness of the global positive solution is achieved. Sufficient conditions guaranteeing the extinction and persistence of the epidemic disease are established. Moreover, the threshold behavior is discussed, and the threshold value R0 is obtained. We show that if R0 extinct with probability one, whereas if R0 > 1, then the system remains permanent in the mean.

Florence Nightingale (1820-1910) and Sir John Forbes (1787-1861): neighbours in Old Burlington Street, Westminster.

Science.gov (United States)

Agnew, Robin

2015-05-01

The year 2010 marks the centenary of the birth of Florence Nightingale and will, no doubt, be universally remembered. Her life and nursing career have recently been fully described by Bostridge. It is less well known that her neighbour from November 1856 was the distinguished Scottish physician Sir John Forbes MD Edin FRCP Lond FRS DCL Oxon. Although they never met, they exchanged copies of each other's books and shared a mutual respect. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Compte rendu critique du livre Voir son steak comme un animal mort, de Martin Gibert

Directory of Open Access Journals (Sweden)

Drolet, Marie-Josée

2016-10-01

Full Text Available This critical review provides, first, a step-by-step synthesis of the arguments presented in each chapter of Martin Gibert’s bookVoir son steak comme un animal mort (Seeing your steak as a dead animal. Second, a critical perspective of the book and a personal reflection are presented.

On broadening the cognitive, motivational, and sociostructural scope of theorizing about gender development and functioning: comment on Martin, Ruble, and Szkrybalo (2002).

Science.gov (United States)

Bandura, Albert; Bussey, Kay

2004-09-01

In their article on gender development, C. L. Martin, D. N. Ruble, and J. Szkrybalo (see record 2002-18663-003) contrasted their conception of gender development with that of social cognitive theory. The authors of this commentary correct misrepresentations of social cognitive theory and analyze the conceptual and empirical status of Martin et al.'s (2002) theory that gender stereotype matching is the main motivating force of gender development. Martin et al. (2002) based their claim for the causal primacy of gender self-categorization on construal of gender discrimination as rudimentary self-identity, equivocal empirical evidence, and dismissal of discordant evidence because of methodological deficiencies. The repeated finding that gendered preferences and behavior precede emergence of a sense of self is discordant with their theory. Different lines of evidence confirm that gender development and functioning are socially situated, richly contextualized, and conditionally manifested rather than governed mainly by an intrinsic drive to match stereotypic gender self-conception. ((c) 2004 APA, all rights reserved)

Sir Harold Delf Gillies, the otolaryngologist and father of modern facial plastic surgery: review of his rhinoplasty case notes.

Science.gov (United States)

Spencer, C R

2015-06-01

Sir Harold Gillies, born in New Zealand, is widely considered a British icon and the father of modern plastic surgery. This article provides an overview of his life and the circumstances which led to him laying the foundations of plastic surgery in Britain in the early twentieth century. A hand search and review of case notes from the Gillies Archives at Queen Mary's Hospital in Sidcup, UK, where he made history, was conducted. Gillies' ongoing legacy was found to also include his influence on the development of his cousin Sir Archibald McIndoe's work. Gillies was a talented sportsman who engaged in charitable activities. Additionally, he was a gifted teacher, with his hospital attracting many young surgeons from around the world. He was found to have expressed genius in both the design and execution of the art and science of surgery. He incepted reconstructive techniques ranging from the world's first gender reassignment operation to facial reanimation procedures for the treatment of facial paralysis. His operative work on ex-servicemen in need of complex rhinoplasty and in particular the inception of the tubed pedicle flap are depicted.

The new investigation of Kimber-Martin-Ryskin unintegrated partons

International Nuclear Information System (INIS)

Modarres, M.; Hosseinkhani, H.

2010-01-01

The three sets of conventional integrated parton distribution functions (PDFs) such as MSTW 2008 (Martin et al), GJR08 (Glueck et al) and Coquet.6 (Nadol sky et al) are used as the inputs to generate the unintegrated parton distribution functions (U PDFs) via the Kimber-Martin-Ryskin (Kmr) procedure and the results are compared with each other. The U PDFs are obtained for several values of the squared transverse momentum component of parton (k t 2 ) and the longitudinal momentum fraction (x). The various aspects of the PDFs and the U PDFs ratios of GJR08 and CTEQ6.6 to MSTW 2008 are analyzed and discussed. In addition to our previous justification (Modarres and Hosseinkani in Nucl Phys A 815:40, 2009) about the stability and the reliability of KMR UPDFs, it is observed here that they are more convergent in the larger values of the scale k t 2 (i.e. the suppression of discrepancies of different PDFs schemes) such that the UPDFs produced via the KMR approach are stable with respect to the variation of the input sets of PDFs and they also tend to a unique value by increasing the scale k t 2 . As the final justifications and conclusions, it seems that the UPDFs produced via the KMR prescription are sufficiently reliable to use in the related phenomenological computations. Our investigation is based on the comparison of the generated UPDFs via the KMR approach by using the MSTW2008, the G J R and the CT Eq.6 sets of the conventional integrated partons as inputs. It is carried out by comparing the ratios G J R/MSTW2008 and CT Eq.6/MSTW2008 and analyzing the results. Although all the UPDFs are well behaved and applicable, but at the higher transverse momentum k 2 t the results are considerable. The most convergent and the unique UPDFs are for the gluon distributions which are noticeably good. (author)

A comédia no romantismo brasileiro: Martins Pena e Joaquim Manuel de Macedo

Directory of Open Access Journals (Sweden)

Vilma Arêas

2006-11-01

Full Text Available O artigo analisa a comédia produzida durante o romantismo brasileiro a partir da obra de Martins Pena e Joaquim Manuel de Macedo. Sustenta-se que Pena, num minucioso trabalho de incorporação de outros gêneros, inaugura a comédia de costumes no país, ao passo que Macedo é visto sobretudo a partir de sua contribuição para a renovação da linguagem teatral. A comédia é aqui entendida à luz da instabilidade de suas relações de sentido e do descompasso próprio do encontro entre formas artísticas forjadas na Europa e o contexto político brasileiro.The article analyses the comedy produced during Brazilian romanticist period taking the work of Martins Pena and Joaquim Manuel de Macedo as a guideline. It states that Pena, taking advantage of other genres, founded comedy of manners in Brazil, whereas Macedo is understood against the framework of the transformations of dramatic language. Comedy is analyzed here in relation to its instability of form and the tension between European ideals and Brazilian political environment.

Jean-Martin Charcot, father of modern neurology: an homage 120 years after his death

OpenAIRE

Gomes, Marleide da Mota; Engelhardt, Eliasz

2013-01-01

Jean-Martin Charcot was a pioneer in a variety of subjects, including nervous system diseases; anatomy; physiology; pathology; and diseases of ageing, joints, and lungs. His medical achievements were mainly based on his anatomopathological proficiency, his observation, and his personal thoroughness that favored the delineation of the nosology of the main neurological diseases, including multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, peroneal muscular atrophy, and hyst...

Koolijuhtide aastakonverents peetakse Pärnus / Martin Kaasik, Jaan Reinson, Raimu Pruul ... [jt.] ; intervjueerinud Ülo Tikk

Index Scriptorium Estoniae

2007-01-01

Eesti Koolijuhtide Ühenduse 17. aastakonverentsist teemal "Õppiv koolijuht". Küsimustele vastavad direktorid: Martin Kaasik (Tallinna Laagna Gümnaasium, Eesti Koolijuhtide Ühenduse üks asutaja), Jaan Reinson (Tartu Descartes'i Lütseum), Raimu Pruul (Häädemeeste Keskkool), Raivo Heinaru (Kohila Gümnaasium), Senta Room (Muhu Põhikool)

Martin Guerre ei tulnud tagasi üksi / Jürgen Beyer ; saksa keelest tõlkinud Tiina Lias

Index Scriptorium Estoniae

Beyer, Jürgen, 1965-

2002-01-01

Rets. rmt.: Davis, Natalie Zemon. Martin Guerre'i tagasitulek / inglise keelest tõlkinud Ainiki Väljataga. Tallinn : Varrak, 2002. Arvustus ilmus ka ajakirjas Vikerkaar, 2002, nr. 8-9 lk. 189-191, kuna käesolevast numbrist oli välja jäänud üks lõik

"I Hope Someone Castrates You, You Perverted Bastard": Martin Cole's Sex Education Film, "Growing Up"

Science.gov (United States)

Limond, David

2009-01-01

This paper concerns the response to the sex education film "Growing Up", made in 1971 by Dr Martin Cole, which used a combination of animation and live action to offer a frank and uncompromising account of sexual reproduction. As part of this, both male and female masturbation and an unsimulated act of male-female coitus featured in the…

Common-mode rejection in Martin-Puplett spectrometers for astronomical observations at millimeter wavelengths.

Science.gov (United States)

D'Alessandro, Giuseppe; de Bernardis, Paolo; Masi, Silvia; Schillaci, Alessandro

2015-11-01

The Martin-Puplett interferometer (MPI) is a differential Fourier transform spectrometer that measures the difference between spectral brightness at two input ports. This unique feature makes the MPI an optimal zero instrument, able to detect small brightness gradients embedded in a large common background. In this paper, we experimentally investigate the common-mode rejection achievable in the MPI at millimeter wavelengths, and discuss the use of the instrument to measure the spectrum of cosmic microwave background anisotropy.

Malingering as a Categorical or Dimensional Construct: The Latent Structure of Feigned Psychopathology as Measured by the SIRS and MMPI-2

Science.gov (United States)

Walters, Glenn D.; Rogers, Richard; Berry, David T. R.; Miller, Holly A.; Duncan, Scott A.; McCusker, Paul J.; Payne, Joshua W.; Granacher, Robert P., Jr.

2008-01-01

The 6 nonoverlapping primary scales of the Structured Interview of Reported Symptoms (SIRS) were subjected to taxometric analysis in a group of 1,211 criminal and civil examinees in order to investigate the latent structure of feigned psychopathology. Both taxometric procedures used in this study, mean above minus below a cut (MAMBAC) and maximum…

Paleodrainages of the Eastern Sahara - The radar rivers revisited (SIR-A/B implications for a mid-tertiary Trans-African drainage system)

Science.gov (United States)

Mccauley, J. F.; Breed, C. S.; Schaber, G. G.; Mchugh, W. P.; Haynes, C. C.

1986-01-01

The images obtained by the Shuttle Imaging Radar (SIR)-A and -B systems over the southwestern Egypt and northwestern Sudan were coregistered with the Landsat images and the existing maps to aid in extrapolations of the buried paleodrainages ('radar rivers'), first discovered by SIR-A. Field observations explain the radar responses of three types of radar rivers, RR-1 (broad, aggraded valleys filled with alluvium), RR-2 (braided channels inset in the RR-1 valleys), and RR-3 (narrow, long, bedrock-incised channels). A generalized model of the radar rivers, based on field studies and regional geologic relations, shows inferred changes in river regimen since the large valleys were established during the later Paleogene-early Neogene. It is suggested that a former Trans-African master stream system may have flowed from headwaters in the Red Sea Hills southwestward across North Africa, discharging into the Atlantic at the Paleo-Niger delta, prior to the Neogene domal uplifts and building of volcanic edifices across the paths of these ancient watercourses.

Occupational exposure following Yttrium-90 microspheres SIR therapy

International Nuclear Information System (INIS)

Fontaine, P.; Boirie, G.; Dieudonne, A.; Leguludec, D.; Lebtahi, R.; Ben Reguiga, M.

2015-01-01

Full text of publication follows. Introduction: Selective Internal Radiation Therapy (SIRT) is a promising technique for solid hepatic neoplasms treatment. SIRT consists in implanting radioactive microspheres (RMS) in targeted hepatic lesions via femoral artery. Two RMS-Therapsheres [glass-microspheres/TSR] and Sir-Spheres [resin-spheres/SSR]- are marketed in the European market, both radiolabeled with Yttrium-90. The objective of this study is to assess occupational exposure for nuclear medicine, radiology and clinical staff involved in Y 90 -RMS preparation and implantation. Materials and methods: The study was conducted on 20 patients treated for Hepato-Cellular Carcinoma: 10 treated with TSR and 10 with SSR. Dose rate (DR, mSv/h) or absorbed doses (mSv) measurements were made during all steps of TSR and SSR handling: sources receipt and unpacking, preparation, transport to radiology, implantation, and patient care. Measurements were made with portable ionization chamber(Babyline/Nardeux), spectrometer(FieldSpect/Aries), digital dosimeter (NED/Unfors) and operational dosimeter (Mk2/Siemens). Values were expressed as mean±SD. Results: patients received of 1.8 GBq to 3.1 GBq of TSR and 0.55 GBq to 2.4 GBq of SSR. TSR were delivered ready-to-use with the prescribed activity. For SSR only one activity was commercially available and shipped (3 GBq at calibration-time)requiring a preparation step to adjust needed activity. DR measured during RMS was 1723 ± 157 μSv/h SSR and 1189 ± 92 μSv/h for TSR. When preparing spheres in radiopharmacy, fingers and whole body doses were respectively 8326 ± 2360 μSv and 12.3 ± 5,2 μSv for Sir-Spheres vs. 33.5 ± 7.8 μSv and 1.1 ± 0.3 μSv for TSR. DR in contact with carrying case during RMS transfer to radiology were 299 ± 102 μSv/h for SSR and 5.3 ± 1.2 μSv/h for TSR. During RMS infusion, radiologist's finger doses were limited to 3.6 ± 1 μSv for SSR and 0.7± 0.3 μSv for TSR. Finally, following RMS

Activatable Optical Imaging with a Silica-Rhodamine Based Near Infrared (SiR700) Fluorophore: A comparison with cyanine based dyes

Science.gov (United States)

McCann, Thomas E.; Kosaka, Nobuyuki; Koide, Yuichiro; Mitsunaga, Makoto; Choyke, Peter L.; Nagano, Tetsuo; Urano, Yasuteru; Kobayashi, Hisataka

2011-01-01

Optical imaging is emerging as an important tool to visualize tumors. However, there are many potential choices among the available fluorophores. Optical imaging probes that emit in the visible range can image superficial tumors with high quantum yields, however, if deeper imaging is needed then near infrared (NIR) fluorophores are necessary. Most commercially available NIR fluorophores are cyanine based and are prone to non-specific binding and relatively limited photostability. Silica-containing rhodamine (SiR) fluorophores represent a new class of NIR fluorophores, which permit photoactivation via H-dimer formation as well as demonstrate improved photostability. This permits higher tumor-to-background ratios (TBRs) to be achieved over longer periods of time. Here, we compared an avidin conjugated with SiR700 (Av-SiR700) to similar compounds based on cyanine dyes (Av-Cy5.5 and Av-Alexa Fluor 680) in a mouse tumor model of ovarian cancer metastasis. We found that the Av-SiR700 probe demonstrated superior quenching enabling activation after binding-internalization to the target cell. As a result, Av-SiR700 had higher TBRs compared to Av-Cy5.5, and better biostability compared to Av-Alexa Fluor 680. PMID:22034863

Prevalence of ciguatoxins in lionfish (Pterois spp.) from Guadeloupe, Saint Martin, and Saint Barthélmy Islands (Caribbean).

Science.gov (United States)

Soliño, Lucía; Widgy, Saha; Pautonnier, Anthony; Turquet, Jean; Loeffler, Christopher R; Flores Quintana, Harold A; Diogène, Jorge

2015-08-01

Lionfish (Pterois spp.) are invasive species that have recently spread throughout the Caribbean. Lionfish are available for purchase in local markets for human consumption in several islands of the region. We examined the prevalence of ciguatoxins (CTXs) in lionfish from the French Antilles, a ciguatera-endemic region. The neuroblastoma-2a (N2a) cell assay was used to assess composite cytotoxicity in 120 fish samples collected from the surrounding waters of Guadeloupe (n = 60), Saint Barthélemy Islands (n = 55) and Saint Martin (n = 5). Twenty-seven of these samples exhibited CTX-like activity by the N2a assay. Ciguatoxin (CTX) was confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in multiple samples that presented highest composite toxicity levels by N2a. Those fish found to contain CTXs were all from Saint Barthélemy. Lionfish from Guadeloupe and Saint Martin did not exhibit toxin activity, although the sample size from Saint Martin was insufficient to draw any conclusions as to the incidence of CTXs. In this study, we provide information about the potential hazard of ciguatera associated with the consumption of lionfish from known endemic areas. We also demonstrate the utility of the cell-based assay combined with LC-MS/MS to assess activity and to provide structural confirmation of CTXs respectively. Copyright © 2015 Elsevier Ltd. All rights reserved.

Applicability of Martin close-quote s equations in high-energy elastic hadron scattering

International Nuclear Information System (INIS)

Kundrat, V.; Lokajicek, M.

1997-01-01

The validity region of Martin close-quote s equations enabling one to determine the t dependence of the real part of the elastic hadron amplitude from its imaginary part is critically reexamined. It can be concluded on the basis of a more precise analysis that quite unjustified and in principle incorrect physical results are obtained if the equations are used outside this region, i.e., for |t|approx-gt 0.15 GeV 2 . copyright 1997 The American Physical Society

POTENCIAL SOCIAL DO MUNICÍPIO DE SILVEIRA MARTINS, RS: CONTRIBUIÇÃO AO ZEE

Directory of Open Access Journals (Sweden)

Franciele Francisca Marmentini Rovani

2016-06-01

Full Text Available Esta pesquisa consistiu em identificar e diagnosticar as potencialidades sociais do município de Silveira Martins/RS, segundo a metodologia proposta por Becker e Egler (1996 para o Zoneamento Ecológico-Econômico (ZEE. Deste modo, utilizou-se como base cartográfica os setores censitários do município e dados referentes à economia, educação, política e saneamento básico. Com base nas informações elaborou-se um banco de dados e por meio da álgebra de mapas ponderou-se os indicadores em valores de alto, médio e baixo potencial de acordo com o potencial natural, humano, produtivo e institucional, derivando o mapa de potencial social. No município de Silveira Martins predomina o potencial mediano na maioria dos indicadores analisados, isto significa que não foi evidenciado potencial alto ou baixo. Verificou-se que o município apresenta equilíbrio entre as restrições territoriais e o potencial de expansão produtivo. Isso pode ser considerado como um aspecto positivo e com políticas públicas o desenvolvimento sustentável poderá ser intensificado.

The leadership principles of Dr. Martin Luther King, Jr. and their relevance to surgery.

Science.gov (United States)

Brunicardi, F Charles; Cotton, Ronald T; Cole, George W; Martinez, George

2007-01-01

In order to face the challenges in healthcare this century, it is essential that surgeons understand modern leadership principles. One of the greatest leaders in history was Dr. Martin Luther King, Jr., who provides a shining example of level-5 leadership for us to study. The study of leadership principles of great leaders can provide us with practical methods of conflict resolution as well as inspiration to keep us engaged and focused. As leaders of the medical community, we face numerous challenges, including discovering and implementing new treatments for disease, providing care for the indigent, overcoming educational challenges such as incorporating the ACGME Core Competencies into our surgical training and promoting diversity in education. Achieving these goals is often hindered by the environment in which we labor-nearly 50 million are uninsured, the rising cost of medical care is currently at 16% of the GNP, and reimbursement rates are falling-which makes the practice of surgery a significant challenge. Effective leadership will be paramount in achieving these goals. In this editorial, which summarizes a presentation given to the Surgical Section of the annual National Medical Association meeting, five important leadership principles that are important for surgeons have been selected and related to the outstanding leadership of Dr. Martin Luther King, Jr.

Dutch House Martins Delichon urbicum gain blood parasite infections over their lifetime, but do not seem to suffer

NARCIS (Netherlands)

Piersma, Theunis; van der Velde, Marco; Bairlein, F.

In a southern Spanish population of the colonial-breeding Afrotropical migrant House Martins Delichon urbicum, a high overall prevalence of (molecularly assayed) haemosporidian infections (in the non-parasitological literature usually denoted with the inclusive term 'malaria') was associated with

Threshold dynamics and ergodicity of an SIRS epidemic model with Markovian switching

Science.gov (United States)

Li, Dan; Liu, Shengqiang; Cui, Jing'an

2017-12-01

This paper studies the spread dynamics of a stochastic SIRS epidemic model with nonlinear incidence and varying population size, which is formulated as a piecewise deterministic Markov process. A threshold dynamic determined by the basic reproduction number R0 is established: the disease can be eradicated almost surely if R0 disease persists almost surely if R0 > 1. The existing method for analyzing ergodic behavior of population systems has been generalized. The modified method weakens the required conditions and has no limitations for both the number of environmental regimes and the dimension of the considered system. When R0 > 1, the existence of a stationary probability measure is obtained. Furthermore, with the modified method, the global attractivity of the Ω-limit set of the system and the convergence in total variation to the stationary measure are both demonstrated under a mild extra condition.

Martin Gibbs (1922-2006): Pioneer of (14)C research, sugar metabolism & photosynthesis; vigilant Editor-in-Chief of Plant Physiology; sage Educator; and humanistic Mentor.

Science.gov (United States)

Black, Clanton C

2008-01-01

The very personal touch of Professor Martin Gibbs as a worldwide advocate for photosynthesis and plant physiology was lost with his death in July 2006. Widely known for his engaging humorous personality and his humanitarian lifestyle, Martin Gibbs excelled as a strong international science diplomat; like a personal science family patriarch encouraging science and plant scientists around the world. Immediately after World War II he was a pioneer at the Brookhaven National Laboratory in the use of (14)C to elucidate carbon flow in metabolism and particularly carbon pathways in photosynthesis. His leadership on carbon metabolism and photosynthesis extended for four decades of working in collaboration with a host of students and colleagues. In 1962, he was selected as the Editor-in-Chief of Plant Physiology. That appointment initiated 3 decades of strong directional influences by Gibbs on plant research and photosynthesis. Plant Physiology became and remains a premier source of new knowledge about the vital and primary roles of plants in earth's environmental history and the energetics of our green-blue planet. His leadership and charismatic humanitarian character became the quintessence of excellence worldwide. Martin Gibbs was in every sense the personification of a model mentor not only for scientists but also shown in devotion to family. Here we pay tribute and honor to an exemplary humanistic mentor, Martin Gibbs.

The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from Narcissus 'Sir Winston Churchill'

NARCIS (Netherlands)

Ingkaninan, K.; Hazekamp, A.; de Best, C.M.; Irth, H.; Tjaden, U.R.; van der Heijden, R.; van der Greef, J.; Verpoorte, R.

2000-01-01

An HPLC with on-line coupled UV/MS-biochemical detection method for acetylcholinesterase (AChE) inhibitors in natural sources has been developed. The potential of this method is shown by the isolation of a new AChE inhibitor from the alcoholic extract of Narcissus 'Sir Winston Churchill'. Combining

Sir Sayyid Ahmed Kahn's History of the Bijnor Rebellion, Translated with Notes and Introduction. South Asia Series, Occasional Paper No. 17.

Science.gov (United States)

Michigan State Univ., East Lansing. Asian Studies Center.

The Bijnor Rebellion of 1857 was a revolt of the Muslim minority in the Bijnor district of India against the British East India Company and Hindu loyalists. Sir Sayyid Ahmad Khan was an Indian Muslim serving the British Company. His account of the events of 1857 is the only one produced by an Indian who both participated in and analyzed the…

Sir Karl Popper (1902-1994): in memoriam, 15 years later.

Science.gov (United States)

Notturno, Mark Amadeus

2009-12-01

September 17th, 2009 marks the 15th anniversary of Sir Karl Popper's death. Popper was an outspoken champion of critical rationalism, and a constant critic of authoritarian tendencies in science and society. He was also one of the spiritual founders of this journal and served on its first editorial advisory board. Popper was recognized around the world as one of the 20th century's greatest philosophers of science and one of its most articulate and influential critics of Marxism and closed society. When he died, the contemporary wisdom among professional philosophers was that his philosophy was generally right-but somehow obsolete. Some commentators said that it was now obvious that scientific theories cannot be shown to be true. Others said that we had witnessed the end of history and that his critique of closed societies, while no doubt important in its day, had been fully assimilated into Western thinking and still had meaning, if at all, only for the democracies in transition that were trying to emerge from the former Soviet Union. But 15 years after his death, a look at science and society around the world gives us good reason to remember his philosophy.

Reconnaissance geologic mapping of a portion of the rain‐forest‐covered Guiana Shield, Northwestern Brazil, using SIR-B and digital aeromagnetic data

Science.gov (United States)

Pellon de Miranda, Fernando; McCafferty, Anne E.; Taranik, James V.

1994-01-01

This paper documents the result of an integrated analysis of spaceborne radar (SIR-B) and digital aeromagnetic data carried out in the heavily forested Guiana Shield. The objective of the research is to interpret the geophysical data base to its limit to produce a reconnaissance geologic map as an aid to ground work planning in a worst‐case setting. Linear geomorphic features were identified based on the interpretation of the SIR-B image. Digital manipulation of aeromagnetic data allowed the development of a color‐shaded relief map of reduced‐to‐pole magnetic anomalies, a terrace‐magnetization map, and a map showing the location of maximum values of the horizontal component of the pseudogravity gradient (magnetization boundary lines). The resultant end product was a reconnaissance geologic map where broad terrane categories were delineated and geologic faults with both topographic and magnetic expression were defined. The availability of global spaceborne radar coverage in the 1990s and the large number of existing digital aeromagnetic surveys in northwestern Brazil indicate that this approach can be potentially useful for reconnaissance geologic mapping elsewhere in the Guiana Shield.

The ethical and poetic reason in the poems of Ana Martins Marques

OpenAIRE

Pietrani, Anélia Montechiari

2015-01-01

Na obra da jovem poeta mineira Ana Martins Marques, autora de A vida submarina e Da arte das armadilhas, a sensibilidade feminina e a disciplina estética são marcas significativas. Ler seus poemas, especialmente seus metapoemas, e a arquitetura de seus textos faz-nos situar a novíssima poesia brasileira na atualidade do século XXI, de modo a refletir sobre o papel, o valor e o lugar da poesia na contemporaneidade, como potência e busca de significados em que confluem a razão ética e a poética...

Entrapment of the Martin-Gruber branch of median nerve in the forearm

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Anu Vinod Ranade

2016-07-01

Full Text Available We report a rare case of a dual neuro-vascular variation, which was observed in the right extremity of male cadaver. About an inch inferior to the elbow joint, three branches arose from the median nerve. These were the anterior interosseous branch, a Martin-Gruber branch (MGB and a muscular branch. The MGB coursed infero-medially to join with the ulnar nerve by running posterior to the ulnar artery. It was surprising to observe that the MGB passed between the ulnar artery and its venae comitantes. There was an acute angulation of the MGB here, suggesting entrapment at this site.

Pragmatic Analyses of Martin Luther King (Jr)'s Speech: "I Have a Dream"--An Introspective Prognosis

Science.gov (United States)

Josiah, Ubong E.; Oghenerho, Gift

2015-01-01

This paper investigates the speech of Martin Luther King (Jr.) titled: "I Have a Dream", presented in 1963 at the Lincoln Memorial. This speech is selected for use because it involves a speaker and an audience who belong to a particular speech community. The speech is about the failed promises by the Americans whose dream advocate…

Owen Martin Phillips (1930-2010)

Science.gov (United States)

Olson, Peter

2011-02-01

Owen Martin Phillips, a pioneer in geophysical fluid dynamics, died at home on 13 October 2010 in Chestertown, Md., at the age of 79. To his many friends and colleagues, Phillips was an inspirational and gracious person who combined a deep intellect, a lively spirit, and a generous heart that matched his passionate interest in the geophysical sciences. Phillips was born on 30 December 1930 in Parramatta, N. S. W., Australia. In 1948 he enrolled in the University of Sydney, where he earned a B.S. in applied mathematics in 1952. That same year, he joined the Cavendish Laboratory at Cambridge University as a research student, where he began to apply to the ocean concepts in turbulent flow recently developed by Andrei Kolmogorov, G. I. Taylor, and George Batchelor. While attending the 1956 celebration of Taylor's seventieth birthday, Phillips heard Fritz Ursell declare that “the process by which ocean waves are generated by the wind cannot be regarded as known.” In 1957 the Journal of Fluid Mechanics contained two remarkable papers offering contrasting theories for ocean wave generation. One paper, by the applied mathematician John Miles (J. Fluid Mech., 2(5), 417-445, 1957), proposed that energy transfer from the air to the sea occurs at a critical layer in the atmosphere boundary layer. The other paper, by Phillips, then 26 years old (J. Fluid Mech., 3(2), 185-204, 1957), proposed that turbulent pressure fluctuations in the wind resonate with propagating ocean waves, forcing them to grow. Together these became known as the Phillips-Miles process, and it was the opening salvo in Phillips's 50-year career of innovative contributions to geophysics through fluid mechanics.

Contamination by mercury in air of the mining district of San Martin de Loba in Bolivar's Department, Colombia; Contaminacion por mercurio en aire del distrito minero de San Martin de loba en el Departamento de Bolivar, Colombia

Energy Technology Data Exchange (ETDEWEB)

Olivero V, J.; Young C, F.; Caballero G, K., E-mail: jolivero@unicartagena.edu.co [Universidad de Cartagena, Facultad de Ciencias Farmaceuticas, Grupo de Quimica Ambiental y Computacional, Calle de la Universidad 36-100, Cartagena de Indias (Colombia)

2014-06-01

Mercury (Hg) is a heavy metal, considered a highly toxic pollutant. In its elemental state is volatile, making it easy to transport over long distances through the atmosphere, so that environmental pollution caused by it is a serious problem worldwide. Activities such as gold mining, where metallic Hg is used, have contributed with its global distribution, affecting ecosystems and human health. The aim of this study was to determine the levels of total mercury (T-Hg) in air in gold mining areas in Southern Bolivar, particularly in the mining district of San Martin de Loba, in the municipalities of San Martin de Loba and Barranco de Loba (Mina Santa Cruz), Colombia. In situ analyses were performed by atomic absorption spectroscopy, using a portable Ra-915 + Zeeman mercury analyzer. In Mina Santa Cruz, one of the most important gold mines in Colombia, concentrations of Hg in air ranged between 163.7 ± 6.6 and 40 455 ± 2154 mg/m{sup 3}, while in the urban area of San Martin de Loba varied from 223.6 ± 20.8 to 27 140 ± 212.5 ng/m{sup 3}. In those places where an amalgam burning process was taking place at the time of the measurements, Hg concentrations reached values of 40 455 ± 2154 ng/m{sup 3}. These data imply a severe occupational exposure to Hg for operators and citizens living in cities located near mines. Therefore, it is important to regulate and control the use of Hg in gold mining, avoiding a chronic impact of the metal on the health of people and the environment. (author)

Discovery of uranium by Martin Heinrich Klaproth 200 years ago

Energy Technology Data Exchange (ETDEWEB)

Schuettmann, W

1989-10-01

200 years ago - on September 24, 1789 - the pharmacist Martin Heinrich Klaproth (1743-1817) stated his discovery of uranium in the hearing of the Royal Prussian Academy of sciences in Berlin. This jubilee gave occasion to appreciate that discovery. The first part of the paper gives a brief bibliography of the researcher. His course of life from a pharmaceutical apprentice to the leading analytical chemist of his epoch is outlined; his performance and discoveries, in particular in the field of mineral chemistry, are appreciated. The second part deals with the discovery of uranium and his lifelong pursuit of the new metal in more detail. After briefly appreciating Klaproth's personality as a researcher, finally the importance is indicated that uranium meanwhile has gained as a source of nuclear power for the human race. (author).

Ob the Froissart-Martin bound in spaces with compact dimensions

CERN Document Server

Petrov, V A

2002-01-01

It is shown by the example of the 5-dimensional space-time, that by availability of the additional compact (space-time-like) measurements to the general Minkowski space all the conditions for proving the Froissart-Martin bound retain their force. Thus, by the circumference R -> 0 the theory smoothly transfers to the theory of the neutral scalar field in the 4-dimensional Minkowski space-time. It was assumed in this work, that the masses are bound from below by the non-zero value. The bounds for elastic scattering by absence of the mass gap are trivial, however in this case it is obviously possible to obtain also nontrivial bounds for complete inelastic cross sections. It takes place in the Regge-eikonal approach though there exist no strong proof for it

Martin Marietta Energy Systems Environmental Management Plan, FY 1985-1989

International Nuclear Information System (INIS)

Furth, W.F.; Cowser, K.E.; Jones, C.G.; Mitchell, M.E.; Perry, T.P.A.; Stair, C.L.; Stinton, L.H.

1985-05-01

This plan contains the most recent revisions (as of April 1, 1985) identifying and resolving environmental problems during the next five years at the four installations managed for DOE by Martin Marietta Energy Systems, Inc. (Energy Systems). These installations are Oak Ridge National Laboratory (ORNL), Oak Ridge Gaseous Diffusion Plant (ORGDP), Oak Ridge Y-12 Plant (Y-12), and Paducah Gaseous Diffusion Plant (PGDP). The report is not an exhaustive catalogue of environmental programs for which funds will be or have been requested. The thrust is to categorize the environmental challenges by the nature of the challenge. The challenges are identified by categories: (1) radioactive waste, (2) hazardous waste, (3) co-contaminated waste (hazardous and radioactive contaminated), (4) conventional waste, (5) monitoring, and (6) remedial actions and decommissioning

Martin Marietta Energy Systems Environmental Management Plan, FY 1985-1989

Energy Technology Data Exchange (ETDEWEB)

Furth, W.F.; Cowser, K.E.; Jones, C.G.; Mitchell, M.E.; Perry, T.P.A.; Stair, C.L.; Stinton, L.H.

1985-05-01

This plan contains the most recent revisions (as of April 1, 1985) identifying and resolving environmental problems during the next five years at the four installations managed for DOE by Martin Marietta Energy Systems, Inc. (Energy Systems). These installations are Oak Ridge National Laboratory (ORNL), Oak Ridge Gaseous Diffusion Plant (ORGDP), Oak Ridge Y-12 Plant (Y-12), and Paducah Gaseous Diffusion Plant (PGDP). The report is not an exhaustive catalogue of environmental programs for which funds will be or have been requested. The thrust is to categorize the environmental challenges by the nature of the challenge. The challenges are identified by categories: (1) radioactive waste, (2) hazardous waste, (3) co-contaminated waste (hazardous and radioactive contaminated), (4) conventional waste, (5) monitoring, and (6) remedial actions and decommissioning.

Martin Chalfie y la proteína verde fluorescente Martin Chalfie y la proteína verde fluorescente

Directory of Open Access Journals (Sweden)

Zacarías Pereira Vega

2012-12-01

Full Text Available The history of the green fluorescent protein (GFP starts with Osamu Shimomura at the beginning of the 1960s, with his discovery from the extracts of the Aequorea victoria jellyfish. However, it is not until the beginning of the 1990s, that the neurobiologist Martin Chalfie, applying genetic engineering tech- niques, achieved for the first time the heterology expression of the GFP in prokaryotes (E. coli and eukaryotes (Caernohabditis elegans, from a clone of the jellyfish’s gen that codifies the GFP prepared by Douglas Prasher. Besides fluorescing in green, the results from this work also demonstrated that it does not require any other cofactor or enzyme of the jellyfish for its expression or for the own forming of a fluorophore. At the same time, Chalfie proposed that the GFP could be used for the marking of cells on living ani- mals or the tag of proteins. Based upon these results, many scientists started working on research related to the GFP; actually this protein is used on different fields such as biotechnol- ogy, development biology, environmental chemistry and medicine. In the case of the latter, it has helped to elucidate the cellular mechanisms from which diseases are made of. Science owes Roger Tsien, amongst other contributions, the creation of differ- ent mutations of the GFP.La historia de la proteína verde fluorescente (GFP se inicia con Osamu Shimomura a principios de la década de 1960, con su descubrimiento de esta proteína a partir de extractos de la medusa Aequorea victoria. Sin embargo, es a principios de la década de 1990 que el neurobiólogo Martin Chalfie, aplicando técnicas de ingeniería genética, logra por primera vez la expresión heteróloga de la GFP en procariotas (Escherichia coli y eucariotas (Caernohabditis elegans, a partir de un clon del gen de la medusa que codifica a la GFP, preparado por Douglas Prasher. Además de fluorescer en verde, los resultados de este trabajo también demostraron que no se

Sir John Adams - His Legacy to the World of Particle Accelerators

CERN Multimedia

CERN. Geneva

2009-01-01

John Adams acquired an unrivalled reputation for his leading part in designing and constructing the PS in CERN’s early days. In 1968, and after several years heading a fusion laboratory in the UK, he came back to Geneva to pilot the SPS project to approval and then to direct its construction. At the time of his untimely death in 1984 he had built Europe’s two largest proton accelerators at CERN. He went on, during the second of his terms as DG, to lay the groundwork for the proton-antiproton collider which led to the discovery of the intermediate vector boson. How did someone without any formal academic qualification achieve this? What was the magic behind his leadership? How did he achieve political success with the Member States of CERN in turning the almost hopeless quest for approval of the SPS to CERN’s advantage? How did he view his US counterpart, R. R. Wilson? The speaker, who worked many years alongside Adams, will discuss these questions and speculate on how Sir John Adams might have viewed t...

A Historical Survey of Sir Karl Popper's Contribution to Quantum Mechanics

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William M. Shields

2012-11-01

Full Text Available Sir Karl Popper (1902-1994, though not trained as a physicist and embarrassed early in his career by a physics error pointed out by Einstein and Bohr, ultimately made substantial contributions to the interpretation of quantum mechanics. As was often the case, Popper initially formulated his position by criticizing the views of others - in this case Niels Bohr and Werner Heisenberg. Underlying Popper's criticism was his belief that, first, the Copenhagen interpretation of quantum mechanics abandoned scientific realism and second, the assertion that quantum theory was complete (an assertion rejected by Einstein among others amounted to an unfalsifiable claim. Popper insisted that the most basic predictions of quantum mechanics should continue to be tested, with an eye towards falsification rather than mere adding of decimal places to confirmatory experiments. His persistent attacks on the Copenhagen interpretation were aimed not at the uncertainty principle itself and the formalism from which it was derived, but at the acceptance by physicists of an unclear epistemology and ontology that left critical questions unanswered. Quanta 2012; 1: 1–12.

The SIR model of Zika virus disease outbreak in Brazil at year 2015

Science.gov (United States)

Aik, Lim Eng; Kiang, Lam Chee; Hong, Tan Wei; Abu, Mohd Syafarudy

2017-05-01

This research study demonstrates a numerical model intended for comprehension the spread of the year 2015 Zika virus disease utilizing the standard SIR framework. In modeling virulent disease dynamics, it is important to explore whether the illness spread could accomplish a pandemic level or it could be eradicated. Information from the year 2015 Zika virus disease event is utilized and Brazil where the event began is considered in this research study. A three dimensional nonlinear differential equation is formulated and solved numerically utilizing the Euler's method in MS excel. It is appeared from the research study that, with health intercessions of public, the viable regenerative number can be decreased making it feasible for the event to cease to exist. It is additionally indicated numerically that the pandemic can just cease to exist when there are no new infected people in the populace.

Un Woyzeck sui fronti del Novecento. «Eiche und Angora» di Martin Walser

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Maurizio Pirro

2014-10-01

Full Text Available Martin Walser’s play Eiche und Angora (1962 deals with the persistence of totalitarianism-oriented mental structures after the Second World War and the collapse of the Nazi regime. Walser represents political history as strongly opposed to the private sphere of ordinary people. Adjustment to the post-war situation of the Bundesrepublik and continuity with the historical past are seen by Walser as equivalent forms of self-defense against the inhuman attitude of political power.

Sir William Burnett (1779-1861), professional head of the Royal Naval Medical Department and entrepreneur.

Science.gov (United States)

Penn, Christopher

2004-08-01

Sir William Burnett (1779-1861) had an active career as a Royal Navy surgeon in the French Revolutionary and Napoleonic Wars, including service at the battles of St Vincent, the Nile and Trafalgar. From 1822 to 1855 he was professional head of the Royal Naval Medical Department, when he provided effective leadership in a time of great change. Although his official work earned him the reputation of a "hard-working, unimaginative, somewhat harsh man", his correspondence shows a very humane centre under the official carapace. His official performance and reputation were both eroded towards the end of his career by his determined promotion of zinc chloride, for which he held lucrative patents.

Dynamics of a stochastic delayed SIR epidemic model with vaccination and double diseases driven by Lévy jumps

Science.gov (United States)

Liu, Qun; Jiang, Daqing; Shi, Ningzhong; Hayat, Tasawar

2018-02-01

In this paper, we study the dynamics of a stochastic delayed SIR epidemic model with vaccination and double diseases which make the research more complex. The environment variability in this paper is characterized by white noise and Lévy noise. We establish sufficient conditions for extinction and persistence in the mean of the two epidemic diseases. It is shown that: (i) time delay and Lévy noise have important effects on the persistence and extinction of epidemic diseases; (ii) two diseases can coexist under certain conditions.

El Mediterráneo a través de la ficción: el extraño caso de Sir John Mandeville

Directory of Open Access Journals (Sweden)

Morales Osorio, Susana

2006-06-01

Full Text Available

The Travels of Sir John Mandeville presents the ficticious construction of the Orient through a travels tale which is primarily shaped as a pilgrimage to Jerusalem. Over and above the critical controversy about the existence of Sir John Mandeville, this book depicts in a very accurate way several key topics in the literature of the Middle Ages as it is the conception of the travel through the medieval peregrination, the homo viator as a consequence of the religious becoming which steamed the Middle Ages, or the Bible as the geography of the known world and the destination of the medieval curiosity. On the other hand, the tale shows a very special devising of the Other, of the unknown, by means of a mythical perspective, that is, through the recreation of fascinating mirabilia collection that still impress the current reader.