Sample records for sir ian william
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Directory of Open Access Journals (Sweden)
Stephen J. Greenberg, MSLS, PhD
2017-04-01
Full Text Available There are times when something is simply so familiar that we can no longer see it at all. It can be a story, or a concept, or even a flesh-and-blood person. Familiarity breeds not only contempt, but a kind of invisibility as well. For too many of us, such is the case with Sir William Osler. In his time (1849–1919, many considered him to be one of the greatest practitioners, teachers, and writers ever in the field of medicine. He was instrumental in the founding of the Medical Library Association (MLA and was elected its second president.
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Sir William Jenner (1815-1898) and Queen Victoria.
Seddon, David; Queen Victoria
2004-08-01
This biographical note outlines the work of Sir William Jenner (1815-1898), court physician 1861-93 and President of the Royal College of Physicians 1881-8. He was the first to distinguish between typhoid and typhus both clinically and pathologically.
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Ian D. Copestake, The Ethics of William Carlos Williams’s Poetry.
Directory of Open Access Journals (Sweden)
Aristotle University of Greece
2011-09-01
Full Text Available Ian D. Copestake’s monograph on William Carlos Williams’s poetry offers a well-informed and well-documented insight into the connection between Williams’s writing with Unitarianism and Emersonian thinking. In this very well-written and accessible book, the reader gets introduced to a number of poems in addition to excerpts from Williams’s essays, letters and autobiography which facilitate the understanding and appreciation of the poet’s attempt to promote “independent thought and action” (5....
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Sir William Osler's speech at Troy: a Trojan horse?
Moran, Michael E
2012-01-01
Troy, New York, is a city of 55,000 people in upstate New York located along the Hudson River. A city of surprisingly rich cultural heritage, it was the home of New York state's first hospital outside New York City. The 50th anniversary celebration of Troy's hospital brought William Osler to the city as the keynote speaker. This speech, delivered on November 28, 1900, is one of Sir William's less well known addresses. Osler began his comments with Sir Thomas More's Utopia and talked at length about the hospital, its obligations, the influences it has upon the community, and the role of physicians and surgeons. He broached one of his old saws, the salary of attending physicians and their needed role in hospital management. His words were published in the diamond jubilee's records, but the hospital did not outlive its prominent guest professor, and it closed its doors in 1914. Just like the great historical city of Troy, New York's own Troy was on the brink of decline, and its hospital would be the first fatality. Therefore, it is almost prescient that the words of Osler, taken into historical context juxtaposed against the socioeconomic forces at work, are akin to the Greek's offering of a wooden edifice to end the Trojan War.
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Sir William Mitchell (1925-2002)
2002-01-01
Sir William (Bill) Mitchell, former President of the CERN Council, died on 30th October 2002 at the age of 77. Mitchell was professor of Physics at Oxford University from 1978 to 1989, having previously been Professor of Physics, Dean of Science and Deputy Vice-Chancellor at Reading University. From 1985 to 1990 he was Chairman of the UK's Science and Engineering Research Council (SERC), which at the time was the funding agency for the UK's participation in the CERN programme. As Chairman, Mitchell was one of the UK representatives on the CERN Council, and in 1991 he was elected President, a position he held for three years. This was a difficult period for CERN. Financial problems were being faced in many member states, notably in Germany as a result of unification. This led to calls for reductions in the CERN budget and, more significantly, to requests for delays in consderation of future programmes. On the other hand for the future of CERN and the progress of elementary particle physics, it was necessary...
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Ut Pictura Poesis : dialéctica entre palabras e imagen en Sir William Sterling Maxwell
Directory of Open Access Journals (Sweden)
Hilary Macartney
2002-01-01
Full Text Available En el presente artículo se analiza la estrecha relación entre la historia del arte de Sir William Stirling Maxwell, su biblioteca y su colección artística. Este vínculo encierra la clave para la comprensión de su excepcional aportación a la historiografía del arte español. Sus diversas actividades, como historiador del arte, coleccionista de libros y cuadros, y director de ediciones privadas de libros raros, fueron todas manifestaciones de su gran fascinación por el paralelo entre la literatura y el arte, la palabra y la imagen. Tal relación se encuentra incluso en el esquema decorativo de su biblioteca.This article examines the remarkable unity between Sir William Stirling Maxwell's art history, his library and his art collection and argües that this relationship is the key to understanding his unique contribution to scholarship of Spanish art. In particular, it will be shown that his actlvities as an art historian, bibliophile, art collector and editor of prívate editions of rare books were all expressions of his fascination with the relationship between literature and art in general, and more specifically between word and image. Even the decorative scheme of his library emphasised this relationship.
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Sir William Turner (1832-1916) - Lancastrian, anatomist and champion of the Victorian era.
Wessels, Quenton; Correia, Janine Carla; Taylor, Adam M
2016-11-01
Sir William Turner, a Lancastrian, was renowned as a scientist, anatomist and a great reformer of medical education. His students became anatomists at various international institutions, which consequently shaped the future of anatomy as a subject matter both in the United Kingdom and in South Africa. Although Turner's accomplishments have been documented, little is known about the details that determined his career path and the individuals that shaped his future. Here the authors aim to highlight some aspects of Turner's academic achievements and his personal life as well as how he crossed paths with other great minds of the Victorian era including Richard Owen, Charles Darwin, James Paget and Joseph Lister. © The Author(s) 2015.
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Penn, Christopher
2004-08-01
Sir William Burnett (1779-1861) had an active career as a Royal Navy surgeon in the French Revolutionary and Napoleonic Wars, including service at the battles of St Vincent, the Nile and Trafalgar. From 1822 to 1855 he was professional head of the Royal Naval Medical Department, when he provided effective leadership in a time of great change. Although his official work earned him the reputation of a "hard-working, unimaginative, somewhat harsh man", his correspondence shows a very humane centre under the official carapace. His official performance and reputation were both eroded towards the end of his career by his determined promotion of zinc chloride, for which he held lucrative patents.
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Mullaney, James
2007-01-01
Deep-sky observers are always on the lookout for new observing challenges. "The Herschel Objects, and How to Observe them" offers an exciting opportunity to retrace the footsteps of Sir William Herschel, discoverer of Uranus and arguably the greatest visual observer and celestial explorer that ever lived!Following a biography of Herschel that details his life and the telescopes he used, this practical observer's guide lists all the most impressive of Herschel's star clusters, nebulae and galaxies.More than 600 of the brightest of the objects that Herschel observed are covered, and there are detailed descriptions and images of almost 200 of the very best Herschel objects for amateur astronomers.
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DEFF Research Database (Denmark)
2015-01-01
Ian Ingram: Next Animals is an exhibition catalogue presenting research on the work by Ian Ingram in relation to his exhibition Next Animals at Nikolaj Kunsthal in 2015.......Ian Ingram: Next Animals is an exhibition catalogue presenting research on the work by Ian Ingram in relation to his exhibition Next Animals at Nikolaj Kunsthal in 2015....
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Obituary: Ian R. Bartky, 1934-2007
Dick, Steven J.
2009-01-01
Ian Robertson Bartky, a physical chemist who turned to history for his second career, died 18 December 2007 of complications from lung cancer. He was 73. In addition to his scientific career, he will be remembered for his meticulous research on the evolution of time systems, especially for his two books Selling the True Time: Nineteenth Century Timekeeping in America (Stanford University Press, 2000), and One Time Fits All: The Campaigns for Global Uniformity (Stanford University Press, 2007). Ian was born on 15 March 1934 in Chicago, Illinois. He was the son of Walter Bartky, a Professor of Astronomy at the University of Chicago, and eventually its Dean of the Division of Physical Sciences. The elder Bartky's astronomy textbook, Highlights of Astronomy, published in 1935 and reprinted as late as 1964, includes a considerable discussion of time and standard meridians, which may have influenced Ian, even though his father died in 1958 at the age of 57 when Ian would have been only in his early 20s. Imbued with the love of science from his father, Ian graduated from Illinois Institute of Technology, and went on to obtain his doctorate in physical chemistry from the University of California Berkeley. He mentor was Nobelist William F. Giauque, and Ian always spoke fondly of Giauque's influence in setting rigorous standards that Ian followed when he joined the National Bureau of Standards [NBS] in 1961. Ian spent most of his career there, and it was there that he acquired his professional interest in time, notably when the House Commerce Committee asked him in the mid-1970s to determine whether the dates of Daylight Saving Time should be extended. This resulted in an NBS report in 1976, which concluded that any energy savings would be miniscule. With his usual attention to detail, Ian researched the entire history of the problem, and thus acquired his second great love after science--history. With Elizabeth Harrison he published a well-known article on the issues
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Sir William Osler's perceptions of urolithiasis and the case of the indigo calculus.
Moran, Michael E; Das, Sakti; Rosenberg, Stuart A
2005-12-01
Sir William Osler published his textbook, The Principles and Practice of Medicine, in 1892. It became the definitive treatise on a wide variety of diseases. The section on nephrolithiasis clearly presents the etiology, pathology, symptoms, diagnosis, and treatments. What remains a mystery is the mention, under rare forms of human stones, of a type called "indigo." A search of Index Medicus starting from 1909 backward to its inception in 1879 was performed for key words "indigo," "calculus," "renal" or "bladder stones" and "indicanuria." Twelve textbooks of urology published before 1940 were scrutinized for references to indigo calculi. Only two references to indigo were found, both related to its use for treating constipation (1887 and 1891). Of the 12 textbooks, only 4 make passing reference to "indigo stones." They all mention that such calculi are very rare, but direct references to cases are lacking. One textbook references a study of blue stones from Egyptian mummies. It is unlikely that Osler's reference to an indigo calculus was taken lightly during his writing of The Principles and Practice of Medicine. The case of the indigo calculus is fascinating and perhaps enlightening if only for the source of Osler's intrigue.
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Vyas, Shreena A; Desai, Sukumar P
2015-05-01
Sir Ronald Aylmer Fisher and William Sealy Gosset were responsible for laying the foundations of statistical inference. Tests that bear their names are used by students and researchers in a wide variety of scientific disciplines. Similar and different in many respects, their lives and careers are the subject of this essay. They were not teacher and pupil; in fact the student was 14 years older than the professor. Their careers did not require them to interact with one another much but they were aware of one another's work. Although Sir Ronald is assigned the role of the professor, his success as a teacher was impaired by his inability to understand the limitations of his students. Meanwhile Gosset was forced to publish his work under the pseudonym 'Student' in order to make contributions to the field of mathematical statistics. Both men are undisputed giants in the field of statistics and we celebrate their achievements as much as we try to understand their struggles. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
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[Sir Geoffrey Keynes 1887-1982. Surgical pioneer, medical historian, humanist].
Bergljung, Lars
2005-01-01
Sir Geoffrey Keynes (1887 - 1982), was a pioneer in the surgery of breast cancer and thymic deseases, n.b. in patients suffering from myastenia gravis. He strongly disapproved of the longstanding dogma of so called radical mastectomy in breast cancer, and advocated a more limited surgical approach, followed by radiation therapy. This was done more than fifty years before breastconserving surgery has become the therapy of choice and against considerable opposition from the surgical establishment of his days. He also became a pioneer in the surgical treatment of myastenia gravis by thymectomy, at a time when there was no real understanding of the pathophysiology of the disease and when considerable controversy existed as to the importance or non importance of concomitant tumour formation in the thymus. Besides being a busy surgeon Sir Geoffrey was a medical historian, writing the biography of among others William Harvey, a bibliographer with a special interest in the poet and artist William Blake and a bibliophil with a large book collection of great value to medical history.
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Patterson, John; George, Robert
2018-03-01
In London, November 1915, a telegram was received at the home of William Henry Bragg from the secretary of the Academy of Science in Stockholm announcing the award of the Nobel Prize in Physics for "the analysis of crystal structures by means of X-rays". A second similar telegram was addressed to his 25 year old son William Lawrence Bragg (Jenkin, 2008). This article commemorates the centenary of that event and the unveiling of a bust of Sir William Bragg alongside that of his son, Sir Lawrence Bragg, on North Terrace in Adelaide where he spent 23 years of his early career. Copyright © 2018. Published by Elsevier Ltd.
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OBITUARY: Sir William Mitchell Physicist and enthusiast for science
Cowley, R
2002-01-01
"William Mitchell was successively head of Physics at Reading and Oxford universities, and Chairman of the Science and Engineering Research Council from 1985 to 1990. He is largely responsible for the excellent neutron and X-ray facilities that are available for research by scientists in the UK. He was one of the first to realise that these uniquely powerful facilities would be essential tools not only for physicists but also for chemists, biologists, materials scientists and engineers" (1 page).
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[Sir William Richard Gowers: author of the "bible of neurology"].
Hirose, Genjiro
2014-11-01
William Richard Gowers is one of the great pioneers in neurology and the author of the well-known neurology textbook, "A Manual of Diseases of the Nervous System." His concepts of neurology are based on meticulously and carefully accumulated knowledge of history, observations, and neurological examinations of patients with various neurological diseases. He is not only a great neurologist but also a great teacher who loves teaching students and physicians through well-prepared lectures. We can glean the essence of the field of neurology through his life story and numerous writings concerning neurological diseases.
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Sir William Petty: modern epidemiologist (1623-1687).
Banta, J E
1987-01-01
William Petty, physician, epidemiologist, political economist, demographer, cartographer, and administrator was an intellectual product of the seventeenth century. Petty was born in the year 1623 in Romsey, England of lower middle class parents; however, by the time of his death in 1687 he had become a knight of the realm, founder of the Royal Society, and friend of kings. Petty's life reflected the northern renaissance which induced such dramatic changes in science, technology, politics, and entrepreneurship. His education was eclectic, nonetheless he took his Doctor of Physic degree from Oxford in 1649 and became an Oxford don, where he spent the next few years as an academic before undertaking a definitive survey of Ireland on behalf of the Cromwell government. Ireland changed Petty's destiny and he became a man of the world and entrepreneur which stimulated his interest in public policy formulation and economics. It was Petty's peculiar genius to be innovative in the application of measurement, statistics, and mathematics to socioeconomic and demographic phenomena. As a physician he related his knowledge of health and disease to these phenomena in what in the modern context would be called human ecology or social epidemiology. These relationships and their measurement were employed to establish an objective set of data which could be analyzed for the purpose of rational public policy planning by the state. This scientific approach to public policy places Petty squarely in the context of modern epidemiologic and public health practice and marks the initiation of a major use of the epidemiologic method.
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Who Invented the Word Asteroid: William Herschel or Stephen Weston?
Cunningham, Clifford J.; Orchiston, Wayne
2011-11-01
William Herschel made the first serious study of 1 Ceres and 2 Pallas in the year 1802. He was moved by their dissimilarities to the other planets to coin a new term to distinguish them. For this purpose he enlisted the aid of his good friends William Watson and Sir Joseph Banks. Watson gave him a long list of possible names, which Herschel rejected. With a lifetime of experience classifying and naming newly found objects in nature, Banks became the man both Erasmus Darwin (in 1781) and William Herschel (in 1802) turned to for sage advice in developing a new descriptive language. In the case of Ceres and Pallas, Banks turned the task over to his friend, the noted philologist Stephen Weston, FRS. It has recently been stated by a noted British historian that it was Weston - not Herschel - who coined the term 'asteroid' to collectively describe Ceres and Pallas. This claim is investigated, and parallels are drawn in the use of neologism in astronomy and botany.
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Non-Fick ian law for the neutron density current
International Nuclear Information System (INIS)
Espinosa P, G.; Vazquez R, R.; Morales S, J.
2008-01-01
In this paper, a fractional wave equation for the average neutron motion in a nuclear reactor is considered. This representation covers the full spectrum of the average neutron transport behavior, i.e., Fick ian and non-Fick ian effects. The fractional diffusion model retains the main dynamic characteristics of the neutron motion. The relaxation time associated with a rapid variation in the neutron flux contains an adjustable parameter, which can be manipulated to obtain the best representation of the neutron transport phenomena. (Author)
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Ramparts of empire the fortifications of sir william jervois, royal engineer 1821 - 1897
Crick, Timothy
2015-01-01
William Jervois was a military engineer who rose to prominence as a result of Lord Palmerston's extensive programme of fortification against a feared French invasion in the middle years of the nineteenth century. Ramparts of Empire is a detailed and engaging study of his life and works.
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Toodayan, Nadeem
2017-08-01
Andreas Vesalius is often regarded as the founding father of modern anatomical study. The quincentennial anniversary of his birth - 31 December 2014 - has been very widely commemorated, and it is the purpose of this article to contrast these celebrations with what happened during the Vesalius quatercentenary year of 1914. More specifically, we look at how Vesalius was perceived a century ago by examining his influence on two of western medicine's most iconic gentlemen - Harvey Williams Cushing (1869-1939) and his larger than life mentor, Sir William Osler (1849-1919).
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Book Review Psychotherapy and Phenomenology By Ian Rory ...
African Journals Online (AJOL)
Book Review Psychotherapy and Phenomenology By Ian Rory Owen (2006) ... Psychotherapy and Phenomenology: On Freud, Husserl and Heidegger. New York: iUniverse. Soft Cover (352 ... AJOL African Journals Online. HOW TO USE ...
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The Spread of Economic Ideas among Romanian People. Case Study: Dionisie Pop Marţian
Directory of Open Access Journals (Sweden)
Angela ROGOJANU
2010-12-01
Full Text Available In the nineteenth century, the accelerating globalizationstarted to show demands that the majority of the Romanians could notunderstand. The delay in the economic development, the political-stateestablishment, the scarcity of instruction and education, the historical andgeographical context marked by hostility, all these formed the gap betweenthe "West" and "East". The renewing economic ideas penetrated hard,often deformed ... The relentless intelligence of some young peopleeducated outside the Romanian land, as Dionisie Pop Marţian (1829-1865, has started the struggle for "the economic emancipation of thenation" by promoting the ideas, the principles and the institutions on whichwas build the prosperity of the West. Seen as a "reactionary" or as a "manof progress", Marţian has delivered a heterogeneous economic outlook, amixture of liberal principles and protectionist principles. The mostsignificant "protection" supported by Marţian was the one againstignorance. The compilation made by Marţian using the works of variousauthors sustaining the "social economy" shows the dimensions of economicbackwardness - the absence of current economic terms from the lexicon.Marţian invents some economic terms, which are understandable, such as:„comerciu”(trade, „manufaptură” (manufacture, „product”, „const”,„fair price”, „banc-rupt” etc. Marţian's mission was clear: "the spreadingof economics through speaking and writing.".
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Directory of Open Access Journals (Sweden)
Nimisha Mittal
2017-05-01
Full Text Available Leishmania donovani, a protozoan parasite is the major causative agent of visceral leishmaniasis. Increased toxicity and resistance to the existing repertoire of drugs has been reported. Hence, an urgent need exists for identifying newer drugs and drug targets. Previous reports have shown sirtuins (Silent Information Regulator from kinetoplastids as promising drug targets. Leishmania species code for three SIR2 (Silent Information Regulator related proteins. Here, we for the first time report the functional characterization of SIR2 related protein 2 (SIR2RP2 of L. donovani.Recombinant L. donovani SIR2RP2 was expressed in E. coli and purified. The enzymatic functions of SIR2RP2 were determined. The subcellular localization of LdSIR2RP2 was done by constructing C-terminal GFP-tagged full-length LdSIR2RP2. Deletion mutants of LdSIR2RP2 were generated in Leishmania by double targeted gene replacement methodology. These null mutants were tested for their proliferation, virulence, cell cycle defects, mitochondrial functioning and sensitivity to known SIR2 inhibitors.Our data suggests that LdSIR2RP2 possesses NAD+-dependent ADP-ribosyltransferase activity. However, NAD+-dependent deacetylase and desuccinylase activities were not detected. The protein localises to the mitochondrion of the promastigotes. Gene deletion studies showed that ΔLdSIR2RP2 null mutants had restrictive growth phenotype associated with accumulation of cells in the G2/M phase and compromised mitochondrial functioning. The null mutants had attenuated infectivity. Deletion of LdSIR2RP2 resulted in increased sensitivity of the parasites to the known SIR2 inhibitors. The sirtuin inhibitors inhibited the ADP-ribosyltransferase activity of recombinant LdSIR2RP2. In conclusion, sirtuins could be used as potential new drug targets for visceral leishmaniasis.
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Tectonic geomorphology of the Andes with SIR-A and SIR-B
Bloom, Arthur L.; Fielding, Eric J.
1986-01-01
Data takes from SIR-A and SIR-B (Shuttle Imaging Radar) crossed all of the principal geomorphic provinces of the central Andes between 17 and 34 S latitude. In conjunction with Thematic Mapping images and photographs from hand-held cameras as well as from the Large Format Camera that was flown with SIR-B, the radar images give an excellent sampling of Andean geomorphology. In particular, the radar images show new details of volcanic rocks and landforms of late Cenozoic age in the Puna, and the exhumed surfaces of tilted blocks of Precambrian crystalline basement in the Sierras Pampeanas.
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Ian Hacking, Learner Categories and Human Taxonomies
Davis, Andrew
2008-01-01
I use Ian Hacking's views to explore ways of classifying people, exploiting his distinction between indifferent kinds and interactive kinds, and his accounts of how we "make up" people. The natural kind/essentialist approach to indifferent kinds is explored in some depth. I relate this to debates in psychiatry about the existence of mental…
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Energy Technology Data Exchange (ETDEWEB)
Celis del A, L.; Rivero, T.; Bucio, F.; Ramirez, R.; Segovia, A.; Palacios, J., E-mail: lina.celis@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)
2015-09-15
En 2011, Mexico won the Colombian international tender for the renewal of instrumentation and control of the IAN-R1 Reactor, to Argentina and the United States. This paper presents the design criteria and the development made for the new digital control system installed in the Colombian nuclear reactor IAN-R1, which is based on a redundant and diverse architecture, which provides increased availability, reliability and safety in the reactor operation. This control system and associated instrumentation met all national export requirements, with the safety requirements established by the IAEA as well as the requirements demanded by the Colombian Regulatory Body in nuclear matter. On August 20, 2012, the Colombian IAN-R1 reactor reached its first criticality controlled with the new system developed at Instituto Nacional de Investigaciones Nucleares (ININ). On September 14, 2012, the new control system of the Colombian IAN-R1 reactor was officially handed over to the Colombian authorities, this being the first time that Mexico exported nuclear technology through the ININ. Currently the reactor is operating successfully with the new control system, and has an operating license for 5 years. (Author)
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2011-01-01
“One day, Sir, you may tax it”… Those are the words I used to get the audience's attention during my talk at the World Economic Forum’s annual meeting in Davos, where I was invited to speak about the science agenda in 2011. For those of you who don’t know the quote, it was Michael Faraday’s response to William Gladstone when asked to comment on the utility of his blue-sky research into the newfangled phenomenon of electricity. So what does a 19th century English scientist have to do with the science agenda today? A great deal, I would contend. Faraday was doing basic science, but he had the foresight to realise that through applied research his findings could one day be developed into something taxable – as it turned out, electric light. Faraday had a sense of the potential of his blue-sky research, but he also appreciated that basic science alone is not enough. This was my key message in Davos. Governments often speak of ...
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Ian Bird, head of Grid development at CERN
Patrice Loïez
2003-01-01
"The Grid enables us to harness the power of scientific computing centres wherever they may be to provide the most powerful computing resource the world has to offer," said Ian Bird, head of Grid development at CERN. The Grid is a new method of sharing processing power between computers in centres around the world.
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Directory of Open Access Journals (Sweden)
Daniele Gallindo Gonçalves Silva
2016-07-01
Full Text Available Este artigo pretende analisar e discutir a natureza do personagem Sir John Falstaff, de William Shakespeare, e de como ele dirige seus relacionamentos com as representações do feminino que o circundam, sua atitude em relação às mulheres e à honra, assim como suas preocupações com seu corpo.
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New digital control system for the operation of the Colombian research reactor IAN-R1
International Nuclear Information System (INIS)
Celis del A, L.; Rivero, T.; Bucio, F.; Ramirez, R.; Segovia, A.; Palacios, J.
2015-09-01
En 2011, Mexico won the Colombian international tender for the renewal of instrumentation and control of the IAN-R1 Reactor, to Argentina and the United States. This paper presents the design criteria and the development made for the new digital control system installed in the Colombian nuclear reactor IAN-R1, which is based on a redundant and diverse architecture, which provides increased availability, reliability and safety in the reactor operation. This control system and associated instrumentation met all national export requirements, with the safety requirements established by the IAEA as well as the requirements demanded by the Colombian Regulatory Body in nuclear matter. On August 20, 2012, the Colombian IAN-R1 reactor reached its first criticality controlled with the new system developed at Instituto Nacional de Investigaciones Nucleares (ININ). On September 14, 2012, the new control system of the Colombian IAN-R1 reactor was officially handed over to the Colombian authorities, this being the first time that Mexico exported nuclear technology through the ININ. Currently the reactor is operating successfully with the new control system, and has an operating license for 5 years. (Author)
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Modernization of control instrumentation and security of reactor IAN - R1
International Nuclear Information System (INIS)
Gonzalez, J. M.
1993-01-01
The program to modernize IAN-R1 research reactor control and safety instrumentation has been carried out considering two main aspects: updating safety philosophy requirements and acquiring the newest reactor control instrumentation controlled by computer, following the present criteria internationally recognized, for safety and reliable reactor operations and the latest developments of nuclear electronic technology. The new IAN-R1 reactor instrumentation consist of two wide range neutron monitoring channels, commanded by microprocessor a data acquisition system and reactor control, (controlled by computers). The reactor control desk is providing through two displays; all safety and control signals to the reactor operators; furthermore some signals like reactor power, safety and period signals are also showed on digital bar graphics, which are hard wired directly from the neutron monitoring channels
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Book Review: Revolutionary Keywords for A New Left by Ian Parker
Directory of Open Access Journals (Sweden)
Eyal Z Clyne
2018-01-01
Full Text Available Eyal Clyne reviews Ian Parker's "Revolutionary Keywords for A New Left" (Winchester and Washington: Zero books ISBN: 978-1-78535-642-1, a book that unlocks complex Left-struggle issues in short and accessible essays.
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Non-Fick ian law for the neutron density current; Atomos para el desarrollo de Mexico
Energy Technology Data Exchange (ETDEWEB)
Espinosa P, G.; Vazquez R, R. [UAM-Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, Mexico D.F. 09340 (Mexico); Morales S, J. [UNAM, Laboratorio de Analisis en Ingenieria de Reactores Nucleares, Paseo Cuauhnahuac 8532, Jiutepec, Morelos 62550 (Mexico)]. e-mail: gepe@xanum.uam.mx
2008-07-01
In this paper, a fractional wave equation for the average neutron motion in a nuclear reactor is considered. This representation covers the full spectrum of the average neutron transport behavior, i.e., Fick ian and non-Fick ian effects. The fractional diffusion model retains the main dynamic characteristics of the neutron motion. The relaxation time associated with a rapid variation in the neutron flux contains an adjustable parameter, which can be manipulated to obtain the best representation of the neutron transport phenomena. (Author)
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The algebra of observables in Gaußian normal spacetime coordinates
Energy Technology Data Exchange (ETDEWEB)
Bodendorfer, Norbert [Faculty of Physics, University of Warsaw,Pasteura 5, 02-093, Warsaw (Poland); Duch, Paweł [Institute of Physics, Jagiellonian University,Łojasiewicza 11, 30-348 Kraków (Poland); Lewandowski, Jerzy; Świeżewski, Jędrzej [Faculty of Physics, University of Warsaw,Pasteura 5, 02-093, Warsaw (Poland)
2016-01-11
We discuss the canonical structure of a spacetime version of the radial gauge, i.e. Gaußian normal spacetime coordinates. While it was found for the spatial version of the radial gauge that a “local” algebra of observables can be constructed, it turns out that this is not possible for the spacetime version. The technical reason for this observation is that the new gauge condition needed to upgrade the spatial to a spacetime radial gauge does not Poisson-commute with the previous gauge conditions. It follows that the involved Dirac bracket is inherently non-local in the sense that no complete set of observables can be found which is constructed locally and at the same time has local Dirac brackets. A locally constructed observable here is defined as a finite polynomial of the canonical variables at a given physical point specified by the Gaußian normal spacetime coordinates.
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Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast.
Hannan, Abdul; Abraham, Neethu Maria; Goyal, Siddharth; Jamir, Imlitoshi; Priyakumar, U Deva; Mishra, Krishnaveni
2015-12-02
Silent information regulator 2 (Sir2), the founding member of the conserved sirtuin family of NAD(+)-dependent histone deacetylase, regulates several physiological processes including genome stability, gene silencing, metabolism and life span in yeast. Within the nucleus, Sir2 is associated with telomere clusters in the nuclear periphery and rDNA in the nucleolus and regulates gene silencing at these genomic sites. How distribution of Sir2 between telomere and rDNA is regulated is not known. Here we show that Sir2 is sumoylated and this modification modulates the intra-nuclear distribution of Sir2. We identify Siz2 as the key SUMO ligase and show that multiple lysines in Sir2 are subject to this sumoylation activity. Mutating K215 alone counteracts the inhibitory effect of Siz2 on telomeric silencing. SUMO modification of Sir2 impairs interaction with Sir4 but not Net1 and, furthermore, SUMO modified Sir2 shows predominant nucleolar localization. Our findings demonstrate that sumoylation of Sir2 modulates distribution between telomeres and rDNA and this is likely to have implications for Sir2 function in other loci as well. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.
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White, Richard T
2014-08-01
To chronicle the creation of the Chair of Psychiatry at the University of Sydney, and the career and legacy, in New South Wales, of the first incumbent, Professor Sir John Macpherson CB MD FRCPE. The creation of the Chair, Macpherson's appointment, and his contributions to psychiatry in Sydney during the 52 months of his tenure, are well documented in contemporaneous sources and demonstrate that he was a very worthy Foundation Professor of Psychiatry at the University of Sydney. There are several possible reasons why Macpherson has been overlooked, including an erroneous statement in The World History of Psychiatry (1975) that William Siegfried Dawson, his successor from 1927 to 1952, was the first Professor of Psychiatry. © The Royal Australian and New Zealand College of Psychiatrists 2014.
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Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education; Volume 21; Issue 6 ... and in particular of mechanics, over thecenturies since Galileo and Newton, we ... and the remarkableways in which his work paved the way to theconstruction ...
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Indian Academy of Sciences (India)
IAS Admin
In this picture, wave fronts are defined as surfaces of constant S(x), while .... Recall here that physical quantities are represented in ... his memory imperishable? Hamilton ... self in the words Ptolemy used of Hipparchus: a lover of labour and a ...
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Williams-Beuren syndrome ... Williams syndrome is caused by not having a copy of several genes. It may be passed down in families. ... history of the condition. However, people with Williams syndrome have a 50% chance of passing the disorder ...
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de Oña Navarro, Maria; Melón García, Santiago; Alvarez-Argüelles, Marta; Fernández-Verdugo, Ana; Boga Riveiro, Jose Antonio
2012-08-01
Although new influenza virus (IAn/H1N1) infections are mild and indistinguishable from any other seasonal influenza virus infections, there are few data on comparisons of the clinical features of infection with (IAn/H1N1) and with other respiratory viruses. The incidence, clinical aspects and temporal distribution of those respiratory viruses circulating during flu pandemic period were studied. Respiratory samples from patients with acute influenza-like symptoms were collected from May 2009 to December 2009. Respiratory viruses were detected by conventional culture methods and genome amplification techniques. Although IAn/H1N1 was the virus most frequently detected, several other respiratory viruses co-circulated with IAn/H1N1 during the pandemic period, especially rhinovirus. The similarity between clinical signs included in the clinical case definition for influenza and those caused by other respiratory viruses, particularly rhinovirus, suggest that a high percentage of viral infections were clinically diagnosed as case of influenza. Our study offers useful information to face future pandemics caused by influenza virus, indicating that differential diagnoses are required in order to not overestimate the importance of the pandemic. Copyright © 2011 Elsevier España, S.L. All rights reserved.
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Human (InConsistencies in Ian McEwan’s Amsterdam
Directory of Open Access Journals (Sweden)
Anghel Florentina
2016-12-01
Full Text Available Ian McEwan’s Amsterdam has supplied its readers with psychological, moral and social topical issues presented in an easy flowing and exhilarating style. Starting from the assumption that life consists of a series of inconsistencies which are inherent and bring their contribution to the individual’s formation, the paper aims at demonstrating that the protagonists’ judgmental and moral inconsistencies, which are used as a plot generator and are environmentally determined, reveal features of their personality.
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The blot on the landscape: Fred Williams and Australian art history
Directory of Open Access Journals (Sweden)
Keith Broadfoot
2014-12-01
Full Text Available A defining shift in Australian art historiography occurred with the publishing of Bernard Smith’s 1980 Boyer Lecture series, The Spectre of Truganini. Seeing the exclusion of an Aboriginal presence in Australian art through the ideas of Freud, the history of Australian art, Smith proposed, was a history of repression. After Smith, Ian McLean has developed the most detailed account of the history of Australian art according to this methodology. This essay examines the work of the modern Australian artist Fred Williams in relation to both Smith and McLean’s understanding of the history of Australian art but to expand on their work I argue that, rather than Freud alone, it is Lacan’s refiguring of Freud that offers us the most insight into Williams’s work. Further, insofar as I argue that the history of Australian art is the very subject matter of Williams’s work, his work stands in for a wider project, the understanding of the history of Australian art according to Lacan’s proposal of a foundational split between the eye and the gaze.
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SirR, a Novel Iron-Dependent Repressor in Staphylococcus epidermidis
Hill, Philip J.; Cockayne, Alan; Landers, Patrick; Morrissey, Julie A.; Sims, Catriona M.; Williams, Paul
1998-01-01
In Staphylococcus epidermidis and Staphylococcus aureus, a number of cell wall- and cytoplasmic membrane-associated lipoproteins are induced in response to iron starvation. To gain insights into the molecular basis of iron-dependent gene regulation in the staphylococci, we sequenced the DNA upstream of the 3-kb S. epidermidis sitABC operon, which Northern blot analysis indicates is transcriptionally regulated by the growth medium iron content. We identified two DNA sequences which are homologous to elements of the Corynebacterium diphtheriae DtxR regulon, which controls, in response to iron stress, for example, production of diphtheria toxin, siderophore, and a heme oxygenase. Upstream of the sitABC operon and divergently transcribed lies a 645-bp open reading frame (ORF), which codes for a polypeptide of approximately 25 kDa with homology to the DtxR family of metal-dependent repressor proteins. This ORF has been designated SirR (staphylococcal iron regulator repressor). Within the sitABC promoter/operator region, we also located a region of dyad symmetry overlapping the transcriptional start of sitABC which shows high homology to the DtxR operator consensus sequence, suggesting that this region, termed the Sir box, is the SirR-binding site. The SirR protein was overexpressed, purified, and used in DNA mobility shift assays; SirR retarded the migration of a synthetic oligonucleotide based on the Sir box in a metal (Fe2+ or Mn2+)-dependent manner, providing confirmatory evidence that this motif is the SirR-binding site. Furthermore, Southern blot analysis of staphylococcal chromosomal DNA with the synthetic Sir box as a probe confirmed that there are at least five Sir boxes in the S. epidermidis genome and at least three in the genome of S. aureus, suggesting that SirR controls the expression of multiple target genes. Using a monospecific polyclonal antibody raised against SirR to probe Western blots of whole-cell lysates of S. aureus, S. carnosus, S. epidermidis
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A Novel Method of SIR Measurement for Power Control in CDMA Systems
International Nuclear Information System (INIS)
Yu, J; Wu, S B; He, J Z
2006-01-01
CDMA is interference limited multiple access system. Power control is an effective way to reduce co-channel interference and solve the near-far problem. Consequently, it can improve the system capacity, and make higher data rate possible. CDMA2000 employs fast closed-loop power control in reverse link to combat channel fading, and the estimation of signal to interference ratio (SIR) is required for closed-loop power control. Transmitting power is adjusted by comparing the SIR estimation with SIR target. So, it is crucial to measure the SIR of received signal accurately. Traditional measurement methods mostly depend on pilot signal strongly, when the pilots are few, there is a greater error brought to the measurement of SIR. In this paper, we discuss the SIR measurement of the received signal under the fewer pilots condition (especially only one pilot symbol) and present a novel SIR measurement method. According to the simulation, the numerical results indicate that the SIR measured by the proposed method is more accurate than the SIR measured by conventional method under fewer pilots condition
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King of Battle: A Branch History of the U.S. Army’s Field Artillery
1992-01-01
massed artillery.82 75. Tidbail, "Artillery Service ian the War of the Rebellion," Sep 1892, p. 888; Rpt, MG Lovell H. Rouseau, CO, 1st Division, US...Artillery School, FieldArilery Military Motor Tramp^ 1935, pp. 29-40;, Maj J.H. Wallace, Lecture, Motor Transportation School, 18 Ian 1934, pp. 108, in...Sir Henry Maitland Wilson, Supreme Allied Commander, Mediterranean Theater, credited field artillery and airpower with the successful defense along the
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Blood on the Stone Ian Smillie se raconte | CRDI - Centre de ...
International Development Research Centre (IDRC) Digital Library (Canada)
Ci-dessous, Ian Smillie raconte comment il en est venu à participer à la lutte pour mettre fin au commerce illicite de diamants, qui a attisé des guerres ayant coûté la vie à des millions de personnes en Afrique. Il décrit cette lutte dans son nouveau livre,Blood on the Stone: Greed, Corruption and War in the Global Diamond ...
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First measurement of 153Sm in the SIR
International Nuclear Information System (INIS)
Michotte, C.; Ratel, G.; Lucas, L.
1999-01-01
In June 1998, the NIST sent to the International Reference System (SIR) a solution of 153 Sm standardized in a 4π ionization chamber. As this radionuclide had not previously been measured in the SIR, the resulting equivalent activity A e,NIST is compared with the value calculated from the efficiency curve of the SIR. However, problems occurred owing to the presence of 154 Eu and 156 Eu impurities in the solution. The manner in which the final equivalent activity value for this solution of 153 Sm has been deduced is described in this report. (authors)
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Lymphocyte integrin expression differences between SIRS and sepsis patients.
Heffernan, D S; Monaghan, S F; Ayala, Alfred
2017-11-01
Systemic Inflammatory Response Syndrome (SIRS) and sepsis remain leading causes of death. Despite many similarities, the two entities are very distinct clinically and immunologically. T-Lymphocytes play a key pivotal role in the pathogenesis and ultimately outcome following both SIRS and sepsis. Integrins are essential in the trafficking and migration of lymphocytes. They also serve vital roles in efficient wound healing and clearance of infections. Here, we investigate whether integrin expression, specifically β1 (CD29) and β2 (CD18), are disrupted in SIRS and sepsis, and assess differences in integrin expression between these two critically ill clinical categories. T-Lymphocytes were isolated from whole blood collected from ICU patients exhibiting SIRS or sepsis. Samples were analyzed for CD18 (β2) and CD29 (β1) on CD3 + T cells through flow cytometry. Septic patients were stratified into either exclusively abdominal or non-abdominal sources of sepsis. CD18 was almost ubiquitously expressed on CD3 + T cells irrespective of clinical condition. However, CD29 (β1 integrin) was lowest in SIRS patients (20.4% of CD3 + T cells) when compared with either septic patients (35.5%) or healthy volunteers (54.1%). Furthermore, there was evidence of compartmentalization in septic patients, where abdominal sources had a greater percentage of CD3 + CD29 + T cells (41.7%) when compared with those with non-abdominal sources (29.5%). Distinct differences in T-cell integrin expression exists between patients in SIRS versus sepsis, as well as relative to the source of sepsis. Further work is needed to understand cause and effect relative to the progression from SIRS into sepsis.
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Validation of the Spanish SIRS with monolingual Hispanic outpatients.
Correa, Amor A; Rogers, Richard; Hoersting, Raquel
2010-09-01
Psychologists are faced with formidable challenges in making their assessment methods relevant to growing numbers of Hispanic clients for whom English is not the primary or preferred language. Among other clinical issues, the determination of malingering has profound consequences for clients. In this investigation, we evaluated a Spanish translation of the Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1992) with 80 Spanish-speaking Hispanic American outpatients. Using a between-subjects simulation design, the Spanish SIRS was found to produce reliable results with small standard errors of measurement. Regarding validity, very large effect sizes (mean Cohen's d= 2.00) were observed between feigners and honest responders for the SIRS primary scales. We consider the potential role of the Spanish SIRS with reference to Spanish translations for other assessment instruments.
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Directory of Open Access Journals (Sweden)
Storgaard Merete
2009-12-01
Full Text Available Abstract Background Sepsis is an infection which has evoked a systemic inflammatory response. Clinically, the Systemic Inflammatory Response Syndrome (SIRS is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in medical emergency ward patients is unknown. Methods We conducted a prospective cohort study of the frequency of SIRS and its relationship to sepsis and death among acutely hospitalised medical patients. In 437 consecutive patients, SIRS status, blood pressure, infection and comorbidity on admission was registered together with 28-day mortality. Results A hundred and fifty-four patients (35% had SIRS on admission, 211 patients (48% had no SIRS, and 72 patients (16% had insufficient data to evaluate their SIRS status. SIRS patients were 2.2 times more frequently infected, with 66/154 SIRS patients versus 41/211 non-SIRS patients: p Conclusion We found SIRS status on admission to be moderately associated with infection and strongly related to 28-day mortality.
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"A'ole" Drugs! Cultural Practices and Drug Resistance of Rural Hawai'ian Youths
Po'A-Kekuawela, Ka'Ohinani; Okamoto, Scott K.; Nebre, La Risa H.; Helm, Susana; Chin, Coralee I. H.
2009-01-01
This qualitative study examined how Native Hawai'ian youths from rural communities utilized cultural practices to promote drug resistance and/or abstinence. Forty-seven students from five different middle schools participated in gender-specific focus groups that focused on the cultural and environmental contexts of drug use for Native Hawai'ian…
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33 CFR 167.1702 - In Prince William Sound: Prince William Sound Traffic Separation Scheme.
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false In Prince William Sound: Prince William Sound Traffic Separation Scheme. 167.1702 Section 167.1702 Navigation and Navigable Waters COAST....1702 In Prince William Sound: Prince William Sound Traffic Separation Scheme. The Prince William Sound...
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William Henry Broadbent (1835-1907) as a neurologist.
Eadie, Mervyn
2015-01-01
By the end of his career, Sir William Broadbent (1835-1907) had become an eminent London general physician who had been appointed Physician-in-Ordinary to King Edward VII and to the Prince of Wales. Previously he had been Physician-in-Extraordinary to Queen Victoria. At earlier stages in his professional life, he had played a significant role in the development of clinical neurology in Victorian-era Britain. In 1866, he had enunciated a principle (Broadbent's hypothesis) that for the first time satisfactorily accounted for the mechanisms by which the trunk and bulbar muscles and the upper face were spared in hemiplegia. He had also carried out original investigations into the distribution of fiber tracts in the human cerebral hemispheres. At intervals over the years, he published on aspects of aphasia and developed a rather complicated though logical conceptual schema of the presumed anatomical background to the process of speech, based on clinic-pathological correlations. His role in all this neurological research and his other contributions on subjects such as neurosyphilis have largely been forgotten by subsequent generations.
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Núñez Pons, Laura; Calcinai, Barbara; Gates, Ruth D
2017-01-01
The sponge fauna has been largely overlooked in the Archipelago of Hawai'i, notwithstanding the paramount role of this taxon in marine ecosystems. The lack of knowledge about Porifera populations inhabiting the Hawai'ian reefs limits the development of ecological studies aimed at understanding the functioning of these marine systems. Consequently, this project addresses this gap by describing the most representative sponge species in the shallow waters of the enigmatic bay of Kane'ohe Bay, in O'ahu Island. A total of 30 species (28 demosponges and two calcareous sponges) living associated to the reef structures are here reported. Six of these species are new records to the Hawai'ian Porifera catalogue and are suspected to be recent introductions to these islands. Morphological descriptions of the voucher specimens are provided, along with sequencing data of two partitions involving the mitochondrial cytochrome oxidase subunit 1 (COI) marker and a fragment covering partial (18S and 28S) and full (ITS-1, 5.8S and ITS-2) nuclear ribosomal genes. Species delimitations based on genetic distances were calculated to valitate how taxonomic assignments from DNA barcoding aligned with morphological identifications. Of the 60 sequences submitted to GenBank ~88% are the first sequencing records for the corresponding species and genetic marker. This work compiles the first catalogue combining morphological characters with DNA barcoding of Hawai'ian sponges, and contributes to the repository of public databases through the Sponge Barcoding Project initiative.
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Directory of Open Access Journals (Sweden)
Laura Núñez Pons
Full Text Available The sponge fauna has been largely overlooked in the Archipelago of Hawai'i, notwithstanding the paramount role of this taxon in marine ecosystems. The lack of knowledge about Porifera populations inhabiting the Hawai'ian reefs limits the development of ecological studies aimed at understanding the functioning of these marine systems. Consequently, this project addresses this gap by describing the most representative sponge species in the shallow waters of the enigmatic bay of Kane'ohe Bay, in O'ahu Island. A total of 30 species (28 demosponges and two calcareous sponges living associated to the reef structures are here reported. Six of these species are new records to the Hawai'ian Porifera catalogue and are suspected to be recent introductions to these islands. Morphological descriptions of the voucher specimens are provided, along with sequencing data of two partitions involving the mitochondrial cytochrome oxidase subunit 1 (COI marker and a fragment covering partial (18S and 28S and full (ITS-1, 5.8S and ITS-2 nuclear ribosomal genes. Species delimitations based on genetic distances were calculated to valitate how taxonomic assignments from DNA barcoding aligned with morphological identifications. Of the 60 sequences submitted to GenBank ~88% are the first sequencing records for the corresponding species and genetic marker. This work compiles the first catalogue combining morphological characters with DNA barcoding of Hawai'ian sponges, and contributes to the repository of public databases through the Sponge Barcoding Project initiative.
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[Williams-Beuren syndrome (Williams syndrome). Case report].
Miklós, Györgyi; Fekete, György; Haltrich, Irén; Tóth, Miklós; Reismann, Péter
2017-11-01
Williams syndrome is a rare genetic disorder, that occurs equally in all ethnic groups and both sexes. The diagnosis might be missed during childhood in mild cases. However, establishing the diagnosis is important, not only to find the cause of intellectual disability but to look for cardiovascular, endocrine, psychiatry, urology and other conditions, which can occur at any age in the patients' lifetime. This case report presents the story of 47-year-old woman, who was admitted with haematemesis. During her stay on the ward, in the light of the distinctive facial features, mental retardation, and social behaviour patterns, the possibility of Williams syndrome emerged. Later, the diagnosis was confirmed by genetic analysis. This female is the oldest living patient with Williams syndrome in Hungary. Orv Hetil. 2017; 158(47): 1883-1888.
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Fujita, T
1998-01-01
In "Dove Cottage", the old house of the poet laureate William Wordsworth (1770-1850) in Grasmere, England, there is a portrait of Sir Humphry Davy (1778-1829). In 1804, Wordsworth invited his young friend to his home. Davy's works in the field of chemistry are well known. Interestingly enough, once he wished he could be a poet. His future seemed to be prosperous and delightful. He was highly evaluated by Robert Southey, poet laureate. But he has chosen the way of chemist. The author found some facts from literatures and received some information by courtesy of the Wordsworth Trust, Centre for British Romanticism. Davy's life and his works were introduced chronologically.
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Early medical scans used animals, too
Marks, Julian
2013-07-01
Ian Pykett's letter on "Pioneering veggie MRIs" (May p23) reminded me of something I heard about Sir Godfrey Hounsfield, who shared the 1979 Nobel Prize for Physiology or Medicine for developing the X-ray computed tomography (CT) scanner.
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SirT1 regulates energy metabolism and response to caloric restriction in mice.
Directory of Open Access Journals (Sweden)
Gino Boily
Full Text Available The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utilize ingested food. These mice are hypermetabolic, contain inefficient liver mitochondria, and have elevated rates of lipid oxidation. When challenged with a 40% reduction in caloric intake, normal mice maintained their metabolic rate and increased their physical activity while the metabolic rate of SirT1-null mice dropped and their activity did not increase. Moreover, CR did not extend lifespan of SirT1-null mice. Thus, SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction.
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33 CFR 147.817 - Sir Douglas Morpeth Tension Leg Platform safety zone.
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Sir Douglas Morpeth Tension Leg... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.817 Sir Douglas Morpeth Tension Leg Platform safety zone. (a) Description. The Sir Douglas Morpeth Tension Leg Platform (Morpeth...
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New Processing of Spaceborne Imaging Radar-C (SIR-C) Data
Meyer, F. J.; Gracheva, V.; Arko, S. A.; Labelle-Hamer, A. L.
2017-12-01
The Spaceborne Imaging Radar-C (SIR-C) was a radar system, which successfully operated on two separate shuttle missions in April and October 1994. During these two missions, a total of 143 hours of radar data were recorded. SIR-C was the first multifrequency and polarimetric spaceborne radar system, operating in dual frequency (L- and C- band) and with quad-polarization. SIR-C had a variety of different operating modes, which are innovative even from today's point of view. Depending on the mode, it was possible to acquire data with different polarizations and carrier frequency combinations. Additionally, different swaths and bandwidths could be used during the data collection and it was possible to receive data with two antennas in the along-track direction.The United States Geological Survey (USGS) distributes the synthetic aperture radar (SAR) images as single-look complex (SLC) and multi-look complex (MLC) products. Unfortunately, since June 2005 the SIR-C processor has been inoperable and not repairable. All acquired SLC and MLC images were processed with a course resolution of 100 m with the goal of generating a quick look. These images are however not well suited for scientific analysis. Only a small percentage of the acquired data has been processed as full resolution SAR images and the unprocessed high resolution data cannot be processed any more at the moment.At the Alaska Satellite Facility (ASF) a new processor was developed to process binary SIR-C data to full resolution SAR images. ASF is planning to process the entire recoverable SIR-C archive to full resolution SLCs, MLCs and high resolution geocoded image products. ASF will make these products available to the science community through their existing data archiving and distribution system.The final paper will describe the new processor and analyze the challenges of reprocessing the SIR-C data.
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Borgonovo, Andrea; Bianchi, Albino; Marchetti, Andrea; Censi, Rachele; Maiorana, Carlo
2012-05-01
After an inferior alveolar nerve (IAN) injury, the onset of altered sensation usually begins immediately after surgery. However, it sometimes begins after several days, which is referred to as delayed paresthesia. The authors considered three different etiologies that likely produce inflammation along the nerve trunk and cause delayed paresthesia: compression of the clot, fibrous reorganization of the clot, and nerve trauma caused by bone fragments during clot organization. The aim of this article was to evaluate the etiology of IAN delayed paresthesia, analyze the literature, present a case series related to three different causes of this pathology, and compare delayed paresthesia with the classic immediate symptomatic paresthesia.
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Development of SIR-C Ground Calibration Equipment
Freeman, A.; Azeem, M.; Haub, D.; Sarabandi, K.
1993-01-01
SIR-C/X-SAR is currently scheduled for launch in April 1994. SIR-C is an L-Band and C-Band, multi-polarization spaceborne SAR system developed by NASA/JPL. X- SAR is an X-Band SAR system developed by DARA/ASI. One of the problems involved in calibrating the SIR-C instrument is to make sure that the horizontal (H) and vertical (V) polarized beams are aligned in the azimuth direction, i.e.. that they are pointing in the same direction. This is important if the polarimetric performance specifications for the system are to be met. To solve this problem, we have designed and built a prototype of a low-cost ground receiver capable of recording received power from two antennas, one H-polarized, the other V-polarized. The two signals are mixed to audio then recorded on the left and right stereo channels of a standard audio cassette player. The audio cassette recording can then be played back directly into a Macintosh computer, where it is digitized. Analysis of.
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Calculation of radiation heat generation on a graphite reflector side of IAN-R1 Reactor
International Nuclear Information System (INIS)
Duque O, J.; Velez A, L.H.
1987-01-01
Calculation methods for radiation heat generation in nuclear reactor, based on the point kernel approach are revisited and applied to the graphite reflector of IAN-R1 reactor. A Fortran computer program was written for the determination of total heat generation in the reflector, taking 1155 point in it
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Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.
Gallo, Christopher M; Smith, Daniel L; Smith, Jeffrey S
2004-02-01
The Saccharomyces cerevisiae Sir2 protein is an NAD(+)-dependent histone deacetylase (HDAC) that functions in transcriptional silencing and longevity. The NAD(+) salvage pathway protein, Npt1, regulates Sir2-mediated processes by maintaining a sufficiently high intracellular NAD(+) concentration. However, another NAD(+) salvage pathway component, Pnc1, modulates silencing independently of the NAD(+) concentration. Nicotinamide (NAM) is a by-product of the Sir2 deacetylase reaction and is a natural Sir2 inhibitor. Pnc1 is a nicotinamidase that converts NAM to nicotinic acid. Here we show that recombinant Pnc1 stimulates Sir2 HDAC activity in vitro by preventing the accumulation of NAM produced by Sir2. In vivo, telomeric, rDNA, and HM silencing are differentially sensitive to inhibition by NAM. Furthermore, PNC1 overexpression suppresses the inhibitory effect of exogenously added NAM on silencing, life span, and Hst1-mediated transcriptional repression. Finally, we show that stress suppresses the inhibitory effect of NAM through the induction of PNC1 expression. Pnc1, therefore, positively regulates Sir2-mediated silencing and longevity by preventing the accumulation of intracellular NAM during times of stress.
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Directory of Open Access Journals (Sweden)
Stephanie Kueng
Full Text Available Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM loci in budding yeast. We have performed a detailed biochemical and genetic analysis of the largest Sir protein, Sir4. The N-terminal half of Sir4 is dispensable for SIR-mediated repression of HM loci in vivo, except in strains that lack Yku70 or have weak silencer elements. For HM silencing in these cells, the C-terminal domain (Sir4C, residues 747-1,358 must be complemented with an N-terminal domain (Sir4N; residues 1-270, expressed either independently or as a fusion with Sir4C. Nonetheless, recombinant Sir4C can form a complex with Sir2 and Sir3 in vitro, is catalytically active, and has sedimentation properties similar to a full-length Sir4-containing SIR complex. Sir4C-containing SIR complexes bind nucleosomal arrays and protect linker DNA from nucleolytic digestion, but less effectively than wild-type SIR complexes. Consistently, full-length Sir4 is required for the complete repression of subtelomeric genes. Supporting the notion that the Sir4 N-terminus is a regulatory domain, we find it extensively phosphorylated on cyclin-dependent kinase consensus sites, some being hyperphosphorylated during mitosis. Mutation of two major phosphoacceptor sites (S63 and S84 derepresses natural subtelomeric genes when combined with a serendipitous mutation (P2A, which alone can enhance the stability of either the repressed or active state. The triple mutation confers resistance to rapamycin-induced stress and a loss of subtelomeric repression. We conclude that the Sir4 N-terminus plays two roles in SIR-mediated silencing: it contributes to epigenetic repression by stabilizing the SIR-mediated protection of linker DNA; and, as a target of phosphorylation, it can destabilize silencing in a regulated manner.
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Directory of Open Access Journals (Sweden)
Marlen Treviño Villalobos
2012-11-01
Full Text Available El Sistema de Información Regional de la Zona Económica Especial (SIR-ZEE nació en Costa Rica aproximadamente en 1998, cuando se concibió la idea de crear un sistema informático para recopilar, gestionar y ofrecer temáticas generadas en forma digital por diferentes entidades públicas y privadas. En el 2008, con los fondos del Programa de Regionalización Interuniversitaria del Consejo Nacional de Rectores, se aprobó la iniciativa SIR-ZEE, Plataforma Tecnológica para el Desarrollo Local, que buscó fortalecer las capacidades productivas y las capacidades de gobernabilidad en la Región Huetar Norte mediante el acceso a la información oportuna y relevante para el desarrollo económico local. Este artículo tiene como objetivo mostrar no solo la relevancia de un sistema de información en la planificación del desarrollo local, sino también que, en la actualidad, el SIR-ZEE se está convirtiendo en una ventaja competitiva para la Región Huetar Norte, ya que facilita el proceso de toma decisiones. Los principales resultados obtenidos al final de la iniciativa fueron una propuesta metodológica para la elaboración de planes estratégicos de desarrollo local en la Región Huetar Norte, la sensibilización de los actores locales sobre la participación ciudadana en las diferentes fases de la planificación, un diagnóstico territorial con el valor agregado de contar con la información georreferenciada y disponible en un sitio web, y avances en la elaboración del Plan estratégico de desarrollo local.The Regional Information System of the Special Economic Zone (SIR-ZEE was born about the year 1998 as a computer system to collect, manage and offer thematic generated in digital format by different public and private entities. In 2008, with the funds of Interuniversity Regionalization Program the National Council of Rectors approved the initiative SIR- ZEE: Platform Technology for Local Development which sought to strengthen productive
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Who’s there? – First morphological and DNA barcoding catalogue of the shallow Hawai’ian sponge fauna
Gates, Ruth D.
2017-01-01
The sponge fauna has been largely overlooked in the Archipelago of Hawai’i, notwithstanding the paramount role of this taxon in marine ecosystems. The lack of knowledge about Porifera populations inhabiting the Hawai’ian reefs limits the development of ecological studies aimed at understanding the functioning of these marine systems. Consequently, this project addresses this gap by describing the most representative sponge species in the shallow waters of the enigmatic bay of Kane’ohe Bay, in O’ahu Island. A total of 30 species (28 demosponges and two calcareous sponges) living associated to the reef structures are here reported. Six of these species are new records to the Hawai’ian Porifera catalogue and are suspected to be recent introductions to these islands. Morphological descriptions of the voucher specimens are provided, along with sequencing data of two partitions involving the mitochondrial cytochrome oxidase subunit 1 (COI) marker and a fragment covering partial (18S and 28S) and full (ITS-1, 5.8S and ITS-2) nuclear ribosomal genes. Species delimitations based on genetic distances were calculated to valitate how taxonomic assignments from DNA barcoding aligned with morphological identifications. Of the 60 sequences submitted to GenBank ~88% are the first sequencing records for the corresponding species and genetic marker. This work compiles the first catalogue combining morphological characters with DNA barcoding of Hawai’ian sponges, and contributes to the repository of public databases through the Sponge Barcoding Project initiative. PMID:29267311
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Neutron flux measurement and thermal power calibration of the IAN-R1 TRIGA reactor
Energy Technology Data Exchange (ETDEWEB)
Sarta Fuentes, Jose A.; Castiblanco Bohorquez, Luis A
2008-10-29
The IAN-R1 TRIGA reactor in Colombia was initially fueled with MTR-HEU enriched to 93% U-235, operated since 1965 at 10 kW, and was upgraded to 30 kW in 1980. General Atomics achieved in 1997 the conversion of HEU fuel to LEU fuel TRIGA type, and upgraded the reactor power to 100 kW. Since the IAN-R1 TRIGA reactor was in an extended shutdown during seven years, it was necessary to repeat some results of the commissioning test conducted in 1997. The thermal power calibration was carried out using the calorimetric method. The reactor was operated approximately at 20 kW during 3.5 hours, with manual power corrections since the automatic control system failed and with the forced refrigeration off. During the calorimetric experiment, the pool temperature was measured with a RTD which is installed near to the core. The dates were collected in intervals of 30 minutes. For establishing thermal power reactor, the water temperature versus the running were registered. For a calculated tank volume of 16 m{sup 3}, the tank constant calculated for the IAN-R1 TRIGA reactor is 0.0539 C/kW-hr. The reactor power determined was 19 kW. The core configuration is a rectangular grid plate that holds a combination of 4-rod and 3-rod clusters. The core contains 50 fuel rods with LEU fuel TRIGA (UZr H1.6) type enriched to 19.7%. The radial reflector consists of twenty graphite elements six of which are used for isotope production. The top an bottom reflectors are the cylindrical graphite end reflectors which are installed above and below of the active fuel section in each fuel rod. The spatial dependence of thermal neutron flux was measured axially in the 3-rod clusters 4C, 3D, 5E and in the 4F graphite element. The spatial distribution of the thermal neutron was determined using a self-powered detector and the absolute value of thermal neutron flux was determined by a gold activation detector. The (n, b- ) reaction is applied to determine the relative spatial distribution of thermal
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Geim, Prof. Sir Andre Konstantin
Indian Academy of Sciences (India)
Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...
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Thomas, John Meurig
2013-10-11
"My greatest achievement has been to combine being a teacher, a researcher, and a popularizer of science for over 50 years. My worst nightmare is to find myself dumbstruck when I am about to give a lecture …︁" This and more about Sir John Meurig Thomas can be found on page 10938. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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The Exploration of Political Conflicts and Personal Relationships in Ian McEwan’s The Innocent
Directory of Open Access Journals (Sweden)
Mina Abbasiyannejad
2014-03-01
Full Text Available Political conflicts have historically affected the relationships of nations. Ian McEwan’s The Innocent is an excellent example of a story set within the web of such a conflict—the Cold War—that was brought about by U.S. and Soviet confrontation over spheres of influence after the Second World War. This article aims to show how Ian McEwan pictures Americanization as a form of cultural politics aimed at spreading American influence throughout the occupied countries such as Germany for political domination. Max Weber’s theory of political power along with semiotics as a tool is the framework of the article. Signs that refer to the Americanization process, including inferences in the dialogues, gestures, choice of food, and even clothing, are scrutinized and interpreted within the socio-political context the of Cold War. The analysis of The Innocent provides an example of the ways in which fiction represents political conflicts permeating personal and intimate relationships, and how such conflicts may result in a sense of mistrust and intrigue among both people and nations.
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McNamara, D. R.
1978-01-01
Sir Karl Popper is one of England's most distinguished contemporary philosophers and it is surprising that his thought has not permeated and informed educational discussion. This paper suggests that educationists have much to learn from Karl Popper's writings and explores ways in which his ideas can illuminate and advance discussion about…
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Indian Academy of Sciences (India)
Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage ... Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more.
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Constitutive Relation of Engineering Material Based on SIR Model and HAM
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Haoxiang He
2014-01-01
Full Text Available As an epidemic mathematical model, the SIR model represents the transition of the Susceptible, Infected, and Recovered. The profound implication of the SIR model is viewed as the propagation and dynamic evolutionary process of the different internal components and the characteristics in a complex system subject to external effect. The uniaxial stress-strain curve of engineering material represents the basic constitutive relation, which also represents the damage propagation in the units of the damaged member. Hence, a novel dynamic stress-strain model is established based on the SIR model. The analytical solution and the approximate solution for the proposed model are represented according to the homotopy analysis method (HAM, and the relationship of the solution and the size effect and the strain rate is discussed. In addition, an experiment on the size effect of confined concrete is carried out and the solution of SIR model is suitable for simulation. The results show that the mechanical mechanism of the parameters of the uniaxial stress-strain model proposed in this paper reflects the actual characteristics of the materials. The solution of the SIR model can fully and accurately show the change of the mechanical performance and the influence of the size effect and the strain rate.
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The Fall of Crete 1941: Was Freyberg Culpable?
2006-06-16
where he served out the war in this capacity and then as the Viceroy of India. Ian Beckett’s chapter contained in John Keegan’s book Churchill’s...Div formed part of an expeditionary force (“W Force”) under General Sir Harry Maitland Wilson,15 along with Blamey’s 6th and 7th Aust Divs, a Polish...Marshal) Sir Henry Maitland Wilson (1881–1964) served in both the Boer War and World War 1. He commanded British forces in Egypt prior to the Greek
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The "Goldberg Variations" and Ian McEwan's Saturday - a study of interdisciplinary analogies
Lykka, Inga Hild
2014-01-01
This thesis examines the musical influence on Ian McEwan’s fiction, in particular that of the Goldberg Variations’ influence on his novel Saturday. This involves an interdisciplinary analysis that compares the two arts, and sheds light on both possibilities and difficulties with regards to which musical features are likely to occur in literature or not. The analysis is founded on previous interdisciplinary studies of music and literature in general, studies of representations of the Goldberg ...
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Productive Second elements in nominal compounds: the matching of Englis and German
Directory of Open Access Journals (Sweden)
Otto Hietsch
1984-12-01
Full Text Available Amongst the treasured reminders of my postgraduate years in England, I cherish a sizable sheaf of manuscript pages, now yellow with age. They are in the hand of Sir William Craigie, that venerable pioneer of lexicographical study. The neat and delicate lines trace out the beginnings of a new venture. Sir William was making a record of the nominal compounds in Beowulf: they are arrayed under the banners of various headwords, each of which, as a glance will show, is a s e c o n d element of composition. Alas, work on the project was never completed, nor are the present generation of Anglo-Saxonists aware of the particular line of argument Sir William had in mind when he set out to re-list the Beowulf compound vocabu lary.
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Energy Technology Data Exchange (ETDEWEB)
Gonzalez P, L. X.; Martinez O, S. A. [Universidad Pedagogica y Tecnologica de Colombia, Grupo de Fisica Nuclear Aplicada y Simulacion, Carretera Central del Norte Km. 1, Via Paipa, 150003 Tunja, Boyaca (Colombia); Vega C, H. R., E-mail: s.agustin.martinez@uptc.edu.co [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)
2014-08-15
By means of Monte Carlo methods, with the code MCNPX, the neutron characteristics of the research nuclear reactor Ian-R1 of Colombia, in power off but with the neutrons source in their start position, have been valued. The neutrons spectra, the total flow and their average power were calculated in the irradiation spaces inside the graphite reflector, as well as in the cells with air. Also the spectra, the total flow and the absorbed dose were calculated in several places distributed along the radial shaft inside the water moderator. The neutrons total flow was also considered to the long of the axial shaft. The characteristics of the neutrons spectra vary depending on their position regarding the source and the material that surrounds to the cell where the calculation was made. (Author)
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Scientific objectives and selection of targets for the SMART-1 Infrared Spectrometer (SIR)
Basilevsky, A. T.; Keller, H. U.; Nathues, A.; Mall, U.; Hiesinger, H.; Rosiek, M.
2004-12-01
The European SMART-1 mission to the Moon, primarily a testbed for innovative technologies, was launched in September 2003 and will reach the Moon in 2005. On board are several scientific instruments, including the point-spectrometer SMART-1 Infrared Spectrometer (SIR). Taking into account the capabilities of the SMART-1 mission and the SIR instrument in particular, as well as the open questions in lunar science, a selection of targets for SIR observations has been compiled. SIR can address at least five topics: (1) Surface/regolith processes; (2) Lunar volcanism; (3) Lunar crust structure; (4) Search for spectral signatures of ices at the lunar poles; and (5) Ground truth and study of geometric effects on the spectral shape. For each topic we will discuss specific observation modes, necessary to achieve our scientific goals. The majority of SIR targets will be observed in the nadir-tracking mode. More than 100 targets, which require off-nadir pointing and off-nadir tracking, are planned. It is expected that results of SIR observations will significantly increase our understanding of the Moon. Since the exact arrival date and the orbital parameters of the SMART-1 spacecraft are not known yet, a more detailed planning of the scientific observations will follow in the near future.
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Indian Academy of Sciences (India)
Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.
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A Transdisciplinary Mind: An Interview with Ian Mitroff
Directory of Open Access Journals (Sweden)
Russ Volckmann
2006-06-01
Full Text Available Known more widely as the “Father of Crisis Management,” University of Southern California professor Ian Mitroff came to the work of Ken Wilber and integral theory over two decades ago. No one else has brought an integral perspective to the fields of management and organization theory for as long as Mitroff. In this interview he talks about the development of his theories, the people he has worked closely with, his spiritual development and the streams of his work, including his research on spirituality in organizations. While his involvement with Wilber’s Integral Institute is not what he would like it to be, he sees there the potential to develop an institution that addresses the politicization and failures of our institutions of higher education. In the face of the crisis in leadership, integral and transdisciplinary approaches have the potential for making a positive difference as we are faced with the dissolution of distinctions that underlie how we make meaning in the world.
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90Sr content in 90Y-labeled SIR-spheres and Zevalin.
Metyko, John; Erwin, William; Poston, John; Jimenez, Sandra
2014-11-01
Three different 90Y internally administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures atMD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize 90Y-labeled microspheres, while Zevalin is an 90Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from 90Y production methods. The 90Y in SIR-Spheres and Zevalin are produced from a 90Sr/90Y generator, which leaves measurable quantities of 90Sr in the final product. TheraSphere 90Y is produced in a nuclear reactor which results in a large number of impurities, most notably 88Y and 91Y. Product information sheets reference these impurities with specific limits given. These limits represent a tiny fraction of the total product activity, and in the case of TheraSphere and SIR-Spheres gamma-emitting impurities, this has been verified in the literature. An analysis of 90Sr impurities in SIR-Spheres and Zevalin is presented in this paper. Impurity quantities were found to be within the vendors’ documented limits.
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Cani kunagine laulja Tallinnas. Led Zeppelin koguneb taas? Ian Brown müüb oma maja liiga kallilt
2002-01-01
Damo Suzuki ja tema uue ansambli Damo Suzuki Network esinemisest Von Krahli Teatri baaris 21.oktoobril. Led Zeppelini plaanist korraldada järgmisel aastal kontserttuur mööda USAd. Ansambli Stone Roses kunagise solisti Ian Browni suvemaja müügist Põhja-Walesis Llithfaenis
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Ian Scott, From Pinewood to Hollywood: British Filmmakers in American Cinema, 1910-1969.
Directory of Open Access Journals (Sweden)
Hilaria Loyo
2011-05-01
Full Text Available Ian Scott’s From Pinewood to Hollywood is a book about the emigration, film careers and socio-cultural influence of British filmmakers who moved to Hollywood during a time period that precedes and follows the studio era, as clearly indicated in its subtitle, British Filmmakers in American Cinema, 1910-1969. Although it is not presented as such, this book can be seen as a timely contribution to the recent academic interest within film studies in the transnational practices that have historical...
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Review of Super Crunchers by Ian Ayers
Directory of Open Access Journals (Sweden)
Eric Gaze
2009-07-01
Full Text Available Ayers, I. Super Crunchers: Why Thinking-by-Numbers Is the New Way to be Smart. (Bantam Dell Publishing Group, 2007. 272 pp. Hard cover $25 ISBN 978-0-553-80540-6.Super Crunchers tells the story of how analyzing data is changing the ways in which decisions are made. We in the National Numeracy Network make a case for the importance of quantitative literacy by referring to how much quantitative information is now available to each of us: “a world awash in numbers.” Ian Ayres zeroes in on the people who are making a living crunching all of these data. From the seemingly innocuous (how wines are rated, and the scouting of baseball players to the life impacting (diagnosis of disease, and parole of inmates, this book paints a vivid portrayal of how data analysis is impacting decision making at every level in our society. The use of simple regression models and randomized trials is calling into question who the “experts” of the twenty-first century will be, and why thinking-by-numbers really is the new way to be smart.
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SIRS Digues 2.0: A Cooperative Software For Levees Management
Directory of Open Access Journals (Sweden)
Moins Isabelle
2016-01-01
Full Text Available SIRS Digues is a computing tool that makes informations on levees more durable and accessible in order to enhance their management. The first version of the software, which was IRSTEA’s initiative, was deployed in 2004. The second version was released in 2015. This article aims at pointing out the innovative aspects of this last version. They concern thematic and functionalities, computing technics and architecture, and last but not least, the business model chosen in order to build a long lasting software. The software’s kernel is sketched to propose a general description of levees: it focuses on description of the levees and linked objects, on disorders that affects them, on works... Most of these topics were already broached by the first version. The kernel of the version 2 may be extended using optional thematic modules. These modules concern: vegetation monitoring, reporting (in coherence with current French regulatory requirements, riverbanks, riverbed... Main functionnalities perfomed by SIRS Digues V1 and V2 are : data structuring and centralisation, quick access to relevant data, reporting and mapping, etc. SIRS Digues 2.0 updates and improves already existing functionalities of the first version. SIRS Digues V2 relies on an documentoriented NoSQL database, CouchDB, and on geospatial libraries, Geotoolkit and Apache-SIS. SIRS Digues V2 was released with a copyleft license. Copyrights belong to the French levees managers’ society, “France Digues”, which acts as a cooperative. Members put their heads together in order to gather their financial capacities and fund software development. France Digues has got the technical and thematic expertise and supply various services to the members. This business model aims to ensure accessibility, durability and adaptability of the software.
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Coal Age Galapogos: Joggins and the lions of nineteenth century geology
Energy Technology Data Exchange (ETDEWEB)
Calder, J.H. [Nova Scotia Department of Natural Resources, Halifax, NS (Canada)
2006-07-01
Since the 1870s, the Joggins coastal section has been recognized as an outstanding section of Carboniferous strata. Accounts about the geology of the Joggins area first appeared in the published literature in 1828. Early history, visits by Sir Charles Lyell and Sir William Logan in 1842 and later, early Geological Survey of Canada field projects, tree trunk fauna, O.C. Marsh's fossil discoveries, Lyell, Dawson and Darwin on evolution, the origin of coal, and discoveries by Sir William Dawson are discussed. The Joggins coastal section has been placed on Canada's Tentative List of future World Heritage Site nominees. 71 refs., 18 figs.
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Chapter II: Twenty Eighth General Assembly Business Sessions
Williams, Robert
2015-08-01
The President of the IAU, Prof. Robert Williams, welcomed the delegates and members to this first business session of the General Assembly. The President invited the General Secretary, Dr. Ian Corbett, to start the business session.
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Raymond Williams and local cultures
B Longhurst
1991-01-01
In this paper it is maintained that Raymond Williams's writings on culture are of great importance to current developments in cultural geography. His work is periodised into three stages and its different subject matters identified. An interpretation of Williams's theory of culture is offered which places particular emphasis on his concepts of 'structure of feeling' and 'knowable community'. The creative tension between Williams's holistic treatment of culture and his stress on cultural strug...
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C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.
Chiang, Wei-Chung; Tishkoff, Daniel X; Yang, Bo; Wilson-Grady, Joshua; Yu, Xiaokun; Mazer, Travis; Eckersdorff, Mark; Gygi, Steven P; Lombard, David B; Hsu, Ao-Lin
2012-09-01
FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4--homolog of mammalian SIRT6 and SIRT7 proteins--promotes DAF-16-dependent transcription and stress-induced DAF-16 nuclear localization. SIR-2.4 is required for resistance to multiple stressors: heat shock, oxidative insult, and proteotoxicity. By contrast, SIR-2.4 is largely dispensable for DAF-16 nuclear localization and function in response to reduced insulin/IGF-1-like signaling. Although acetylation is known to regulate localization and activity of mammalian FoxO proteins, this modification has not been previously described on DAF-16. We find that DAF-16 is hyperacetylated in sir-2.4 mutants. Conversely, DAF-16 is acetylated by the acetyltransferase CBP-1, and DAF-16 is hypoacetylated and constitutively nuclear in response to cbp-1 inhibition. Surprisingly, a SIR-2.4 catalytic mutant efficiently rescues the DAF-16 localization defect in sir-2.4 null animals. Acetylation of DAF-16 by CBP-1 in vitro is inhibited by either wild-type or mutant SIR-2.4, suggesting that SIR-2.4 regulates DAF-16 acetylation indirectly, by preventing CBP-1-mediated acetylation under stress conditions. Taken together, our results identify SIR-2.4 as a critical regulator of DAF-16 specifically in the context of stress responses. Furthermore, they reveal a novel role for acetylation, modulated by the antagonistic activities of CBP-1 and SIR-2.4, in modulating DAF-16 localization and function.
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Pedaru, Tõnu
2007-01-01
Heliplaatidest: Ian Brown "The World is Yours", Jose Gonzales "In Our Nature", Apocalyptica "Worlds Collide" Amiina "Kurr", Will.I.Am "Songs About Girls", Babyshambles "Shotters Nation", Felix da Housecat "Virgo Blaktro ja The Movie Disco", Liars "Liars"
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SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells
Directory of Open Access Journals (Sweden)
Chi-Hsien Peng
2010-06-01
Full Text Available Retinal stem cells bear potency of proliferation, self-renewal, and differentiation into many retinal cells. Utilizing appropriate sensors one can effectively detect the self-renewal and aging process abilities. Silencing information regulator (SirT1, a member of the sirtuin family, is a NAD-dependent histone deacetylase and an essential mediator for longevity in normal cells by calorie restriction. We firstly investigate the SirT1 mRNA expression in retinal stem cells from rats and 19 human eyes of different ages. Results revealed that SirT1 expression was significantly decreased in in vivo aged eyes, associated with poor self-renewal abilities. Additionally, SirT1 mRNA levels were dose-dependently increased in resveratrol- treated retinal stem cells. The expression of SirT1 on oxidative stress-induced damage was significantly decreased, negatively correlated with the level of intracellular reactive oxygen species production. Treatment with resveratrol could effectively further reduce oxidative stress induced by H2O2 treatment in retinal stem cells. Importantly, the anti-oxidant effects of resveratrol in H2O2-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1. SirT1 expression provides a feasible sensor in assessing self-renewal and aging process in retinal stem cells. Resveratrol can prevent reactive oxygen species-induced damages via increased retinal SirT1 expression.
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Directory of Open Access Journals (Sweden)
Reto Melchior
1996-09-01
Full Text Available Luis Bunuel’s last film is based on Pierre Louÿs’ La Femme et le Pantin. This now forgotten bestseller, published in 1898, is drawn from Goya s painting El Pelele, in which four women are playing with a male puppet. In Pierre Louÿs’ novel this scene is inverted so that one woman with two faces plays with four men. In Cet Obscur Objet du Désir this “femme fatale” is interpreted by two actresses. The concentric structure of the film puts focus on a scene of being excluded from knowing. The technique of continually interrupting the flash-back sequences frustrates the audience because of its exclusion from the “real” course of events and gives rise to doubts whether the male protagonist tells the truth about his love-affair or whether he satisfies the curiosity of the audience by telling them Pierre Louÿs’ novel as his own story. This ambiguous art of narration mirrors Bunuel’s claim that the main topic of Cet Obscur Objet du Désir is frustration.
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Sir Charles Scott Sherrington (1857–1952)
Indian Academy of Sciences (India)
Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from twentytwouniversities and ...
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Sir Charles Scott Sherrington (1857–1952)
Indian Academy of Sciences (India)
2016-08-26
Aug 26, 2016 ... Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from ...
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Sir Ronald Ross and the Malarial Parasite
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 7. Sir Ronald Ross and the Malarial Parasite - Discovery of its Route - From Man to Mosquito and Back. Shobhona Sharma. General Article Volume 11 Issue 7 July 2006 pp 4-13 ...
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Directory of Open Access Journals (Sweden)
E. A. Venter
1964-03-01
Full Text Available Die geweldige oplewing van die Christelike wetenskaps- gedagte in ons geeslose tyd, is ongetwyfeld ’n haas onverklaar- bare verskynsel. Dwarsdeur die eeue het Christene ook wetenskap beoefen saam met ongelowiges, maar dit was eers in ons leeftyd dat die principia van die Christelike religie ook vrugbaar gemaak is vir die wetenskapsbeoefening. In hierdie verband sal die name van Dooyeweerd, Vollenhoven, Stoker e.a. steeds met eer vermeld word. Natuurlik het belydende Christene ook voorheen wel deeglik saamgewerk aan die gebou van die wetenskap. Die intieme verband tussen religie, wysbegeerte en wetenskaps beoefening is toe egter nog nie suiwer ingesien nie. Uit hier die tydperk dateer die arbeid van sir Isaac Newton.
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Genetics Home Reference: Williams syndrome
... do well on tasks that involve spoken language, music, and learning by repetition (rote memorization). Affected individuals ... Resources (5 links) Disease InfoSearch: Williams syndrome Genetic Science Learning Center, University of Utah MalaCards: williams-beuren ...
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Calculations and selection of a TRIGA core for the Nuclear Reactor IAN-R1
International Nuclear Information System (INIS)
Castiblanco, L.A.; Sarta, J.A.
1997-01-01
The Reactor Group used the code WIMS reduced to five groups of energy, together with the code CITATION, and evaluated four configurations for a core, according to the grid actually installed. The four configurations were taken from the two proposals presented to the Instituto de Ciencias Nucleares y Energias Alternativas by General Atomics Company. In this paper, the Authors selected the best configuration according to the performance of flux distribution and excess reactivity, for a TRIGA core to be installed in the Nuclear Reactor IAN-R1
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Maximilien Brice
2003-01-01
Visit of His Excellency Mr Ian de Jong, Ambassador, Permanent Representative of the Kingdom of the Netherlands to the United Nations Office in Geneva, June 2003. From left to right: Dr Albert Ijspeert, Deputy Leader, Magnet and electrical systems Group, Accelerator Technology Division; Mr Maarten Wilbers, Legal Service; Prof. Cecilia Jarlskog, Adviser to the Director-General for Member State Relations; Mr Jan van der Boon, Director of Administration; His Excellency Mr Ian de Jong, Ambassador, Permanent Representative of the Kingdom of the Netherlands to the United Nations Office in Geneva; Prof. Frank Linde, NIKHEF; Dr Lucie Linssen Experimental Physics Division, Technical Assistance Group and Mr C. J. van Riel, Ministry of Education, Culture and Science, Netherlands, Dutch Delegate to Council and Finance Committee.
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Milk progesterone to monitor reproductive performance in Holstein Fries ian cows
International Nuclear Information System (INIS)
Lubbadeh, W.F.
1995-01-01
A study was conducted to monitor reproductive of lactating Holstein Fries ian cows by measuring milk progesterone levels. Sequential post-partum milk samples were collected weekly throughout 20 weeks after pregnancy. Progesterone concentrations were determined by solid phase RIA. Lactating cows required an average of 5.2 weeks to resume luteal activity; 48% of the cows conceived after first insemination and had significantly high progesterone concentrations during the first 5 weeks after insemination than cows which returned to heat 5-8 weeks after insemination> Results also revealed that adequate level of progesterone, which varied between 4.2 and 9.1 nmol/l, is required to maintain early pregnancy and progesterone level remains high in pregnant cows. (Author) 17 refs., 3 Tabs
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Sir Ronald Ross and the Malarial Parasite
Indian Academy of Sciences (India)
1997-08-20
Aug 20, 1997 ... In 1857, a General in the Indian Army, Sir C C G Ross and his wife Matilda .... generally low-caste Indians who required a fee before drinking the water and ... nary demand being made upon their systems, as by fatigue, chill,.
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William Butler Yeats’s ‘The Symbolic System’ of William Blake
Directory of Open Access Journals (Sweden)
Arianna Antonielli
2008-03-01
Full Text Available The theosophical systems formulated by great poets, such as William Blake and William Butler Yeats, represent a personal idiosyncratic actualization of an ancient repertoire of magical symbols and occult visions. This study wants to focus the attention on the philosophical, mythical, and esoteric syncretism that W. B. Yeats drew from William Blake’s symbolical system. A fundamental step of Yeats’s deep investigation into the Blakean ‘vision’ was given by his monumental work, written together with Edwin John Ellis, on Blake’s poetic and pictorial production, completed in 1893 with a three-volume edition entitled The Works of William Blake, Poetic, Symbolic, and Critical. This work, published in London by Bernard Quaritch, deeply influenced Yeats’s symbolical and imaginary system, determining its subsequent development up to its codification in the volume of A Vision. With WWB, Yeats was able to systematize for the first time his own thought, giving unity to his Weltanschauung and his poetry. Following this hypothesis, I concentrated on Yeats’s and Ellis’s numerous analyses dedicated to Blake’s mythological and symbolical corpus and, in particular, I examined the last chapter of the first volume of the Quaritch edition. This chapter, entitled “The Symbolic System”, constitutes an unquestionable link between Yeats the reader and scholar of Blake, and Yeats the poet and follower of Blake.
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Directory of Open Access Journals (Sweden)
Lee Jin
2016-12-01
Full Text Available After the Syrian civil war, deaths of those fleeing crisis areas have tragically become a regular news item. Not new to the world, however, such crises emerge from tensions between identity and difference as codified in international politics, whereby refugees and migrants become the Other and subject to unyielding universals, such as the law or narrow concepts of what is right. Indeed, the cultural logic of “global identities” informing the current refugee and migrant crisis seems recurrent, as exemplified in the recent cases of the Tamils from Sri Lanka and the Somalis. The cultural logic of global identity is also reflected in the popular nineteenth-century novella by Sir Arthur Conan Doyle, The Man with the Twisted Lip, in which the main character disguises himself as a professional beggar to appeal to middle class values in order to incite their guilty consciences. Drawing on Ian Baucom, Marc Shell, and Jean-Joseph Goux, this article argues that the main character’s actions reflect and embody the cultural logic of the global politico-economy in late nineteenth century London. As such, Doyle’s novella illustrates the Derridean notion of hospitality by revealing that “identity and difference are mutually constitutive” (Baker 109 and offers insightful commentary on the current refugee and migrant crisis.
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A human neurodevelopmental model for Williams syndrome.
Chailangkarn, Thanathom; Trujillo, Cleber A; Freitas, Beatriz C; Hrvoj-Mihic, Branka; Herai, Roberto H; Yu, Diana X; Brown, Timothy T; Marchetto, Maria C; Bardy, Cedric; McHenry, Lauren; Stefanacci, Lisa; Järvinen, Anna; Searcy, Yvonne M; DeWitt, Michelle; Wong, Wenny; Lai, Philip; Ard, M Colin; Hanson, Kari L; Romero, Sarah; Jacobs, Bob; Dale, Anders M; Dai, Li; Korenberg, Julie R; Gage, Fred H; Bellugi, Ursula; Halgren, Eric; Semendeferi, Katerina; Muotri, Alysson R
2016-08-18
Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon hypersociability and a mosaic of retained and compromised linguistic and cognitive abilities. Nearly all clinically diagnosed individuals with Williams syndrome lack precisely the same set of genes, with breakpoints in chromosome band 7q11.23 (refs 1-5). The contribution of specific genes to the neuroanatomical and functional alterations, leading to behavioural pathologies in humans, remains largely unexplored. Here we investigate neural progenitor cells and cortical neurons derived from Williams syndrome and typically developing induced pluripotent stem cells. Neural progenitor cells in Williams syndrome have an increased doubling time and apoptosis compared with typically developing neural progenitor cells. Using an individual with atypical Williams syndrome, we narrowed this cellular phenotype to a single gene candidate, frizzled 9 (FZD9). At the neuronal stage, layer V/VI cortical neurons derived from Williams syndrome were characterized by longer total dendrites, increased numbers of spines and synapses, aberrant calcium oscillation and altered network connectivity. Morphometric alterations observed in neurons from Williams syndrome were validated after Golgi staining of post-mortem layer V/VI cortical neurons. This model of human induced pluripotent stem cells fills the current knowledge gap in the cellular biology of Williams syndrome and could lead to further insights into the molecular mechanism underlying the disorder and the human social brain.
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Permanence for a Delayed Nonautonomous SIR Epidemic Model with Density-Dependent Birth Rate
Directory of Open Access Journals (Sweden)
Li Yingke
2011-01-01
Full Text Available Based on some well-known SIR models, a revised nonautonomous SIR epidemic model with distributed delay and density-dependent birth rate was considered. Applying some classical analysis techniques for ordinary differential equations and the method proposed by Wang (2002, the threshold value for the permanence and extinction of the model was obtained.
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SIR-2 Data Normalization and Integration with M3 Data
Grumpe, A.; Felder, M. P.; Wöhler, C.; Mall, U.
2013-09-01
The point spectrometer SIR-2 on Chandrayaan-1 provided radiance spectra integrated over circular footprints of 200 m diameter in the wavelength range 934-2410.8 nm in 256 channels [1]. To analyze SIR-2 reflectance spectra in their spatial context, a coregistration to Chandrayaan-1 M³ hyperspectral images [2] as well as a correction for topography and thermal emission are inevitable. The thermal and topographic correction procedure is based on the surface temperature and a digital elevation model (DEM) inferred from M³ data. The corrected reflectance spectra are then normalized to a standard illumination and viewing geometry.
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Neutrons characterization of the nuclear reactor Ian-R1 of Colombia
International Nuclear Information System (INIS)
Gonzalez P, L. X.; Martinez O, S. A.; Vega C, H. R.
2014-08-01
By means of Monte Carlo methods, with the code MCNPX, the neutron characteristics of the research nuclear reactor Ian-R1 of Colombia, in power off but with the neutrons source in their start position, have been valued. The neutrons spectra, the total flow and their average power were calculated in the irradiation spaces inside the graphite reflector, as well as in the cells with air. Also the spectra, the total flow and the absorbed dose were calculated in several places distributed along the radial shaft inside the water moderator. The neutrons total flow was also considered to the long of the axial shaft. The characteristics of the neutrons spectra vary depending on their position regarding the source and the material that surrounds to the cell where the calculation was made. (Author)
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International Nuclear Information System (INIS)
Chang, C.-J.; Hsu, C.-C.; Yung, M.-C.; Chen, K.-Y.; Tzao Ching; Wu, W.-F.; Chou, H.-Y.; Lee, Y.-Y.; Lu, K.-H.; Chiou, S.-H.; Ma, H.-I
2009-01-01
CD133-expressing glioma cells play a critical role in tumor recovery after treatment and are resistant to radiotherapy. Herein, we demonstrated that glioblastoma-derived CD133-positive cells (GBM-CD133 + ) are capable of self-renewal and express high levels of embryonic stem cell genes and SirT1 compared to GBM-CD133 - cells. To evaluate the role of SirT1 in GBM-CD133 + , we used a lentiviral vector expressing shRNA to knock-down SirT1 expression (sh-SirT1) in GBM-CD133 + . Silencing of SirT1 significantly enhanced the sensitivity of GBM-CD133 + to radiation and increased the level of radiation-mediated apoptosis. Importantly, knock-down of SirT1 increased the effectiveness of radiotherapy in the inhibition of tumor growth in nude mice transplanted with GBM-CD133 + . Kaplan-Meier survival analysis indicated that the mean survival rate of GBM-CD133 + mice treated with radiotherapy was significantly improved by Sh-SirT1 as well. In sum, these results suggest that SirT1 is a potential target for increasing the sensitivity of GBM and glioblastoma-associated cancer stem cells to radiotherapy.
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Serum inflammatory markers in the elderly: are they useful in differentiating sepsis from SIRS?
Directory of Open Access Journals (Sweden)
Mahshid Talebi-Taher
2014-06-01
Full Text Available Differentiating sepsis from other noninfectious causes of systemic inflammation is often difficult in the elderly. The aim of this study was to evaluate the ability of C-reactive protein (CRP, Erythrocyte Sedimentation Rate (ESR, procalcitonin (PCT, and Interleukin-6 (IL-6 to identify elderly patients with sepsis. In this single center prospective observational study, we included all consecutive elderly patients admitted with suspected sepsis and systemic inflammatory response syndrome (SIRS in an emergency department. Blood samples for measuring CRP, PCT, IL-6, ESR and white blood cells (WBC count were taken at first day of admission. Sensitivity, specificity, positive and negative predictive values were calculated for each inflammatory markers being studied. A total of 150 elderly patients aged 65 and older, 50 with sepsis and 50 with SIRS, and fifty individuals in a normal health status were included. CRP exhibited the greatest sensitivity (98% and negative predictive value (98.6% and performed best in differentiating patients with sepsis from those with SIRS. In a receiver operating characteristic curve analysis, IL-6 performed best in distinguishing between SIRS and the control group (AUC 0.75, 95% CI. On the other hand, both CRP and ESR appeared to be a more accurate diagnostic parameter for differentiating sepsis from SIRS among elderly patients.
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dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner
Directory of Open Access Journals (Sweden)
Kushal Kr. Banerjee
2012-12-01
Full Text Available Sir2, an evolutionarily conserved NAD+-dependent deacetylase, has been implicated as a key factor in mediating organismal life span. However, recent contradictory findings have brought into question the role of Sir2 and its orthologs in regulating organismal longevity. In this study, we report that Drosophila Sir2 (dSir2 in the adult fat body regulates longevity in a diet-dependent manner. We used inducible Gal4 drivers to knock down and overexpress dSir2 in a tissue-specific manner. A diet-dependent life span phenotype of dSir2 perturbations (both knockdown and overexpression in the fat body, but not muscles, negates the effects of background genetic mutations. In addition to providing clarity to the field, our study contrasts the ability of dSir2 in two metabolic tissues to affect longevity. We also show that dSir2 knockdown abrogates fat-body dFOXO-dependent life span extension. This report highlights the importance of the interplay between genetic factors and dietary inputs in determining organismal life spans.
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Comparison of QSOFA score and SIRS criteria as screening mechanisms for emergency department sepsis.
Haydar, Samir; Spanier, Matthew; Weems, Patricia; Wood, Samantha; Strout, Tania
2017-11-01
The Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) score has been shown to accurately predict mortality in septic patients and is part of recently proposed diagnostic criteria for sepsis. We sought to ascertain the sensitive of the score in diagnosing sepsis, as well as the diagnostic timeliness of the score when compared to traditional systemic inflammatory response syndrome (SIRS) criteria in a population of emergency department (ED) patients treated in the ED, admitted, and subsequently discharged with a diagnosis of sepsis. Electronic health records of 200 patients who were treated for suspected sepsis in our ED and ultimately discharged from our hospital with a diagnosis of sepsis were randomly selected for review from a population of adult ED patients (N=1880). Data extracted included the presence of SIRS criteria and the qSOFA score as well as time required to meet said criteria. In this cohort, 94.5% met SIRS criteria while in the ED whereas only 58.3% met qSOFA. The mean time from arrival to SIRS documentation was 47.1min (95% CI: 36.5-57.8) compared to 84.0min (95% CI: 62.2-105.8) for qSOFA. The median ED "door" to positive SIRS criteria was 12min and 29min for qSOFA. Although qSOFA may be valuable in predicting sepsis-related mortality, it performed poorly as a screening tool for identifying sepsis in the ED. As the time to meet qSOFA criteria was significantly longer than for SIRS, relying on qSOFA alone may delay initiation of evidence-based interventions known to improve sepsis-related outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.
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Delineation of major geologic structures in Turkey using SIR-B data
Toksoz, M. N.; Pettengill, G. H.; Ford, P.; Gulen, L.
1984-01-01
Shuttle Imaging Radar-B (SIR-B) images of well mapped segments of major faults, such as the North Anatolian Fault (NAF) and East Anatolian Fault (EAF) will be studied to identify the prominent signatures that characterize the fault zones for those specific regions. The information will be used to delineate the unmapped fault zones in areas with similar geological and geomorphological properties. The data obtained from SIR-B images will be compared and correlated with the LANDSAT thematic mapper and seismicity alignments based on well constrained earthquake epicenters.
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Handedness and corpus callosal morphology in Williams syndrome.
Martens, Marilee A; Wilson, Sarah J; Chen, Jian; Wood, Amanda G; Reutens, David C
2013-02-01
Williams syndrome is a neurodevelopmental genetic disorder caused by a hemizygous deletion on chromosome 7q11.23, resulting in atypical brain structure and function, including abnormal morphology of the corpus callosum. An influence of handedness on the size of the corpus callosum has been observed in studies of typical individuals, but handedness has not been taken into account in studies of callosal morphology in Williams syndrome. We hypothesized that callosal area is smaller and the size of the splenium and isthmus is reduced in individuals with Williams syndrome compared to healthy controls, and examined age, sex, and handedness effects on corpus callosal area. Structural magnetic resonance imaging scans were obtained on 25 individuals with Williams syndrome (18 right-handed, 7 left-handed) and 25 matched controls. We found that callosal thickness was significantly reduced in the splenium of Williams syndrome individuals compared to controls. We also found novel evidence that the callosal area was smaller in left-handed participants with Williams syndrome than their right-handed counterparts, with opposite findings observed in the control group. This novel finding may be associated with LIM-kinase hemizygosity, a characteristic of Williams syndrome. The findings may have significant clinical implications in future explorations of the Williams syndrome cognitive phenotype.
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33 CFR 167.1700 - In Prince William Sound: General.
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false In Prince William Sound: General... Schemes and Precautionary Areas Pacific West Coast § 167.1700 In Prince William Sound: General. The Prince William Sound Traffic Separation Scheme consists of four parts: Prince William Sound Traffic Separation...
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International Nuclear Information System (INIS)
Xie Yuexia; Zhang Jianghong; Shao Chunlin; Xu Yanwu
2012-01-01
Intratumoral hypoxia is an important contributory factor to tumor cell resistance to radiotherapy. SirT1, a nicotinamide adenine dinucleotide (NAD + )-dependent histone/protein deacetylase, has been linked to the decrease of radiation-induced DNA damage and seems to be critical for cancer therapy. The purpose of this study was to investigate the role of SirT1 in hypoxia-induced radiation response on hepatoma cells. It was found that the administration with resveratrol, a putative SirT1 activator, enhanced the resistance of HepG2 cells against radiation-induced DNA damage of MN formation under hypoxia condition; while nicotinamide, a well-known SirT1 inhibitor, sensitized this radiation damage. Nevertheless, pretreatment of cells with 10058-F4, a specific inhibitor of c-Myc, almost eliminated the nicotinamide-induced radiosensitive effect. Further studies revealed that resveratrol inhibited c-Myc protein accumulation via up-regulation of SirT1 expression and deacetylase activity, and this loss of c-Myc protein was abolished by inhibiting its degradation in the presence of MG132, a potent inhibitor of proteasome. In contrast, nicotinamide attenuated c-Myc protein degradation induced by radiation under hypoxia through inhibition of SirT1 deacetylase activity. Our findings suggest that SirT1 could serve as a novel potent target of radiation-induced DNA damage and thus as a potential strategy to advance the efficiency of radiation therapy in hepatoma entities. (author)
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The susceptible-infected-recovered (SIR) model for viral marketing
Ismail, Siti Suhaila; Akil, Ku Azlina Ku; Chulan, Majdah; Sharif, Noorzila
2017-11-01
Viral marketing is a marketing strategy utilizes social media to spread information about a product or services provided. It is the most powerful way to share information in a short amount of time. The objective of this study is to investigate the dynamic of viral marketing within a time duration in the point of view of mathematics. This study used the epidemiological model known as Susceptible-Infected-Recovered (SIR). The model consists of a system of three differential equations with three state variables namely susceptible (S), infected (I) and recovered (R). It considers a case of SIR model with demography. Numerical experiments have been performed. The results show that viral marketing reaches its peak within two days. The online messages shared will become higher if the initial number of the infected individual has been increased.
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Chapman, Allan
2003-06-01
A careful study of the detailed archives of the Victorian Royal Observatory makes it possible to build up a picture of the employment and working conditions not only of the astronomical staff who worked at Greenwich, but also of the labourers, watchmen, and gate porters. Indeed, the archives open up a window on to how the Observatory was run on a daily basis: how its non-scientific staff were recruited and paid, and what were their terms of employment. They also say a great deal about how Sir George Biddell Airy directed and controlled every aspect of the Observatory's life. Yet while Airy was a strict employer, he emerges as a man who was undoubtedly fair-minded and sometimes even generous to his non-scientific work-force. A study of the Observatory staff files also reveals the relationship between the Observatory labouring staff and the Airy family's domestic servants. And of especial interest is the robbery committed by William Sayers, the Airy family footman in 1868, bringing to light as it does Sir George and Lady Richarda Airy's views on crime and its social causes and consequences, the prison rehabilitation service in 1868, and their opinions on the reform of offenders. Though this paper is not about astronomy as such, it illuminates a fascinating interface where the world of astronomical science met and worked alongside the world of ordinary Victorian people within the walls of one of the nineteenth century's most illustrious astronomical institutions.
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Sir Karl Popper and his philosophy of physics
Jammer, Max
1991-12-01
The eminent mathematical physicist Sir Hermann Bondi once said: “There is no more to science than its method, and there is no more to its method than Popper has said.” Indeed, many regard Sir Karl Raimund Popper the greatest philosopher of science in our generation. Much of what Popper “has said” refers to physics, but physicists, generally speaking, have little knowledge of what he has said. True, Popper's philosophy of science and, in particular, his realistic interpretation of quantum mechanics deviates considerably from the generally accepted doctrine. But as Popper, rightly I think, points out, it is precisely the proliferation of divergent theories which promotes the growth of scientific knowledge; it would be a danger for physics if physicists were dogmatically tied to a single theory or would not test their theory against alternatives. It is for this purpose that, on the occasion of the nonagenarian celebration of Popper's birthday, the present essay has been written.
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Jin, Wanchun; Wachino, Jun-Ichi; Kimura, Kouji; Yamada, Keiko; Arakawa, Yoshichika
2015-05-01
Enterobacteriaceae clinical isolates showing amikacin resistance (MIC 64 to >256 mg/L) in the absence of 16S rRNA methyltransferase (MTase) genes were found. The aim of this study was to clarify the molecular mechanisms underlying amikacin resistance in Enterobacteriaceae clinical isolates that do not produce 16S rRNA MTases. PCR was performed to detect already-known amikacin resistance determinants. Cloning experiments and sequence analyses were performed to characterize unknown amikacin resistance determinants. Transfer of amikacin resistance determinants was performed by conjugation and transformation. The complete nucleotide sequence of the plasmids was determined by next-generation sequencing technology. Amikacin resistance enzymes were purified with a column chromatography system. The enzymatic function of the purified protein was investigated by thin-layer chromatography (TLC) and HPLC. Among the 14 isolates, 9 were found to carry already-known amikacin resistance determinants such as aac(6')-Ia and aac(6')-Ib. Genetic analyses revealed the presence of a new amikacin acetyltransferase gene, named aac(6')-Ian, located on a 169 829 bp transferable plasmid (p11663) of the Serratia marcescens strain NUBL-11663, one of the five strains negative for known aac(6') genes by PCR. Plasmid p11663 also carried a novel ESBL gene, named blaTLA-3. HPLC and TLC analyses demonstrated that AAC(6')-Ian catalysed the transfer of an acetyl group from acetyl coenzyme A onto an amine at the 6'-position of various aminoglycosides. We identified aac(6')-Ian as a novel amikacin resistance determinant together with a new ESBL gene, blaTLA-3, on a transferable plasmid of a S. marcescens clinical isolate. © The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
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Verification of the linearity of the new SIR using sources of 64Cu and 99mTc
International Nuclear Information System (INIS)
Michotte, Carine
2012-02-01
The linearity of the new SIR electronics has been verified by looking for deviations from the exponential decay for several 64 Cu and 99m Tc sources. Data analyses are compared with the half-life used as a fixed or free parameter. It is concluded that no significant non-linearity is observed in the new SIR. For comparison, the same method has been applied to analyse existing data from the original SIR. (author)
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Sir Robert Sidney’s Poems Revisited: the alternative sequence
Relvas, Maria de Jesus C.
1997-01-01
The essay approaches the lyric sequence written by Sir Robert Sidney (1563-1626) in the Elizabethan age, by mainly exploring its unique formal structure, which encloses an alternative sequence formed by a re-numbering of several poems.
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International Nuclear Information System (INIS)
Xie, Yuexia; Tu, Wenzhi; Zhang, Jianghong; He, Mingyuan; Ye, Shuang; Dong, Chen; Shao, Chunlin
2015-01-01
Highlights: • γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells. • SirT1 played a protective role in regulating this bystander effect. • SirT1 contributed to the protective effects via elimination the accumulation of ROS. • The activity of c-Myc is critical for maintaining the protective role of SirT1. - Abstract: Radiation-induced bystander effect (RIBE) has important implications for secondary cancer risk assessment during cancer radiotherapy, but the bystander signaling processes, especially under hypoxic condition, are still largely unclear. The present study found that micronuclei (MN) formation could be induced in the non-irradiated HL-7702 hepatocyte cells after being treated with the conditioned medium from irradiated hepatoma HepG2 and SK-Hep-1 cells under either normoxia or hypoxia. This bystander response was dramatically diminished or enhanced when the SirT1 gene of irradiated hepatoma cells was overexpressed or knocked down, respectively, especially under hypoxia. Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation. But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference. Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion. These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved
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Energy Technology Data Exchange (ETDEWEB)
Xie, Yuexia [Institute of Radiation Medicine, Fudan University, Shanghai (China); Central Laboratory, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai (China); Tu, Wenzhi; Zhang, Jianghong; He, Mingyuan; Ye, Shuang; Dong, Chen [Institute of Radiation Medicine, Fudan University, Shanghai (China); Shao, Chunlin, E-mail: clshao@shmu.edu.cn [Institute of Radiation Medicine, Fudan University, Shanghai (China)
2015-02-15
Highlights: • γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells. • SirT1 played a protective role in regulating this bystander effect. • SirT1 contributed to the protective effects via elimination the accumulation of ROS. • The activity of c-Myc is critical for maintaining the protective role of SirT1. - Abstract: Radiation-induced bystander effect (RIBE) has important implications for secondary cancer risk assessment during cancer radiotherapy, but the bystander signaling processes, especially under hypoxic condition, are still largely unclear. The present study found that micronuclei (MN) formation could be induced in the non-irradiated HL-7702 hepatocyte cells after being treated with the conditioned medium from irradiated hepatoma HepG2 and SK-Hep-1 cells under either normoxia or hypoxia. This bystander response was dramatically diminished or enhanced when the SirT1 gene of irradiated hepatoma cells was overexpressed or knocked down, respectively, especially under hypoxia. Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation. But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference. Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion. These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved.
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William Rowan Hamilton: Mathematical genius
International Nuclear Information System (INIS)
Wilkins, D.R.
2006-01-01
This year Ireland celebrates the bicentenary of the mathematician William Rowan Hamilton, best remembered for quaternions and for his pioneering work on optics and dynamics. Two centuries after his birth, the extent to which terms such as Hamiltonian and Hamiltonian system have entered the everyday language of mathematicians and physicists testifies to the continuing impact of the scientific work of William Rowan Hamilton. (U.K.)
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SIR JOHN CRAWFORD MEMORIAL ADDRESS: Agriculture: The challenges of the 21st century
Beddington, Sir John
2012-01-01
The Sir John Crawford Memorial Address has been presented since 1985, in honour of the distinguished Australian civil servant, educator and agriculturalist in whose name the Crawford Fund was established. Sir John Crawford was a remarkable Australian who contributed at the highest levels, and was a passionate supporter of international agricultural research for development. This talk draws attention to four current and interrelated trends that suggest the world will be rather different by 202...
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Stability analysis of the Euler discretization for SIR epidemic model
International Nuclear Information System (INIS)
Suryanto, Agus
2014-01-01
In this paper we consider a discrete SIR epidemic model obtained by the Euler method. For that discrete model, existence of disease free equilibrium and endemic equilibrium is established. Sufficient conditions on the local asymptotical stability of both disease free equilibrium and endemic equilibrium are also derived. It is found that the local asymptotical stability of the existing equilibrium is achieved only for a small time step size h. If h is further increased and passes the critical value, then both equilibriums will lose their stability. Our numerical simulations show that a complex dynamical behavior such as bifurcation or chaos phenomenon will appear for relatively large h. Both analytical and numerical results show that the discrete SIR model has a richer dynamical behavior than its continuous counterpart
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William Rowan Hamilton: Mathematical genius
Energy Technology Data Exchange (ETDEWEB)
Wilkins, D.R. [School of Mathematics, Trinity College, Dublin (Ireland)]. E-mail: dwilkins@maths.tcd.ie
2005-08-01
This year Ireland celebrates the bicentenary of the mathematician William Rowan Hamilton, best remembered for 'quaternions' and for his pioneering work on optics and dynamics. Two centuries after his birth, the extent to which terms such as 'Hamiltonian' and 'Hamiltonian system' have entered the everyday language of mathematicians and physicists testifies to the continuing impact of the scientific work of William Rowan Hamilton. (U.K.)
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33 CFR 110.233 - Prince William Sound, Alaska.
2010-07-01
... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Prince William Sound, Alaska. 110... ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.233 Prince William Sound, Alaska. (a) The anchorage grounds. In Prince William Sound, Alaska, beginning at a point at latitude 60°40′00″ N., longitude 146°40...
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L’économie politique du désir dans le rituel et le militantisme au SriLanka
Directory of Open Access Journals (Sweden)
Wim Van Daele
2013-03-01
Full Text Available Le désir est au cœur des interactions complexes entre le développement et la religion. Cet article examine ses différentes expressions, comme étant une des préoccupations fondamentales de nombreuses religions, qui motivent à la fois le développement et les alternatives au développement. Au SriLanka, face au changement social, la forme néolibérale et mondialisée du développement est comprise et réinterprétée à travers des idiomes et des formations locales du désir. L’économie néolibérale cultive le désir et mène à un accroissement présumé de la présence des preta (fantômes affamés et avides qui se manifestent parfois au moment de la mort d’une personne. Les fantômes affamés, en tant que formations fétichisées du désir, trouvent un écho chez les consommateurs et les entrepreneurs, qui montrent unappétit insatiable vis-à-vis d’une richesse matérielle en constante croissance. Ainsi, l’apaisement ritualisé des fantômes affamés et le militantisme social de groupes tels que le Movement for National Land and Agricultural Reform (MONLAR sont clairement liés par leur préoccupation mutuelle face à l’insécurité existentielle des êtres humains et non humains, causée par un désir excessif et déséquilibré. L’action rituelle et le militantisme social divergent toutefois dans la formulation explicite de leurs préoccupations spécifiques concernant le désir. Le rituel matérialise et condense l’angoisse liée au désir, alors que le militantisme social décrit la fétichisation du désir en termes économiques, politiques et scientifiques plus abstraits.
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Williams Syndrome with a “Twist”
Directory of Open Access Journals (Sweden)
Despoina Maritsi
2010-01-01
Full Text Available Williams syndrome is a rare genetic condition with multisystemic involvement, caused by a microscopic deletion in the chromosome band 7q11.23. We describe the first case of a toddler with Williams syndrome who developed Benign Paroxysmal Torticollis (BPT, a benign dystonic disorder of unknown aetiology.
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76 FR 1130 - Prince William Sound Resource Advisory Committee
2011-01-07
... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource Advisory... conducted: The Prince William Sound Resource Advisory Committee (RAC) will be discussing and voting on...
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77 FR 45331 - Prince William Sound Resource Advisory Committee
2012-07-31
... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource Advisory... Prince William Sound Resource Advisory Committee (RAC) will be discussing and voting on proposals that...
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Ending Caleb Williams: on storytelling influencing William Godwin’s politics
Directory of Open Access Journals (Sweden)
Peterson Roberto da Silva
2017-12-01
Full Text Available William Godwin escreveu o romance gótico Things as They Are; or, the Adventures of Caleb Williams (“As Coisas como Elas São; ou, as Aventuras de Caleb Williams”, em tradução livre em 1794 para disseminar suas ideias filosóficas e políticas. Inicio o artigo revisando a literatura para demonstrar como sua teoria influenciou tanto sua decisão de escrever ficções quanto o tipo de ficção que ele escreveu, mostrando como o autor usou e inovou convenções do gênero gótico para transmitir suas ideias para um público mais amplo. Então comparo duas perspectivas divergentes na literatura quanto à maneira como suas narrativas influenciaram suas ideias políticas e filosóficas, em particular a partir de comentários acerca do significado e do impacto de mudanças de última hora ao desfecho de Caleb Williams. Argumento que essa relação ambígua entre narrativa e política na obra de Godwin é relevante para reflexões políticas contemporâneas sobre a relação entre representação e ação política, ou como narrativas sobre a condição humana e realidades políticas podem afetas as ideias, atitudes e relações sociais de seus narradores.
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76 FR 18715 - Prince William Sound Resource Advisory Committee
2011-04-05
... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource Advisory... meeting is open to the public. The following business will be conducted: The Prince William Sound Resource...
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Modification of the IAN-R1 reactor
International Nuclear Information System (INIS)
Jaime, J.; Ahumada, S.; Spin, R.A.
1990-01-01
The IAN-R1 reactor is the only nuclear reactor operating in Colombia; it is installed at the Institute of Nuclear Affairs (AIN) in Bogota, which is an official body coming under the Ministry of Mining and Energy. This reactor started operation in January 1965 with a rated power of 10 kW and was modified a year later to operate at 20 kW, which has been its rated power up to the present. Given its importance for the application of nuclear technology in Columbia for various purposes, principally in the areas of neutron activation analysis, determination of uranium content in minerals using the delayed neutron counting method, production of certain radioisotopes such as 198 Au and 82 Br for engineering applications, and production of radioactive material for teaching and research purposes, research has been in progress for some years into ways of increasing its power. The study on experimental requirements and on the demand for locally produced radioisotopes came to the conclusion that its power should be increased to 1000 kW, which would allow the facility to remain on the same site. The modification includes conversion of the core to low-enriched fuel, operation up to 1 MW, modification of the shielding, renovation of instrumentation and installation of a radioisotope processing plant. When the reactor is modified we will be able to produce other radioisotopes for applications in nuclear medicine, industry and engineering; at the same time, the safety of the facility will be optimized and the experimental facilities improved
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Directory of Open Access Journals (Sweden)
Siau Pheng Lee
2016-10-01
Full Text Available Abstract Background The growing interest in problematic hoarding as an independent clinical condition has led to the development of the Saving Inventory-Revised (SI-R to assess hoarding phenomenology. The SI-R is one of the most widely used instruments to measure hoarding symptoms; however, it lacks validation in non-Western samples. Methods The current study examined the construct, convergent, and discriminant validity of the SI-R among 500 outpatients at a psychiatric hospital in Singapore. The three-factor structure solution of the SI-R was fitted in a confirmatory factor analysis. Results The final model achieved mediocre fit (χ2 = 1026.02, df = 186; RMSEA = 0.095, SRMR = 0.06; CFI = 0.86; NNFI = 0.85. Two reverse-coded items (items 2 and 4 were removed due to insufficient factor loadings, resulting in the modified 21-item SI-R (SIR-21. Our findings indicate the need to further examine the construct validity of the SI-R, particularly in non-Western samples. Nonetheless, correlations with other hoarding-related constructs, such as anxiety (Beck Anxiety Inventory and depression (Beck Depression Inventory-II, supported the convergent and discriminant validity of the SIR-21 in our sample. Conclusions Findings in our current majority Chinese sample were consistent with previous observations from other Chinese samples. Implications were discussed from a cross-cultural perspective, such as cultural emphasis on saving for future use and overlap between the concepts of discarding and acquiring in Chinese samples. Future studies should also examine differences among other ethnic groups (e.g., Malay, Indian.
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Energy Technology Data Exchange (ETDEWEB)
Chappell, D. [Williams Energy Canada Inc., Edmonton, AB (Canada)
2004-07-01
Edmonton-based Williams Energy Canada Inc. extracts petrochemicals from oil sands and operates a straddle plant business and an olefins business. This presentation provided an update of both businesses and reviewed the advantage of polypropylene production in Alberta, with reference to premium markets and to comparative rail costs to Chicago via Texas, and rail costs to Chicago from Alberta. Williams' straddle plant business includes the Cochrane Straddle Plant, the Empress 2 Straddle Plant, and the Empress 5 Straddle Plant. The Fort McMurray Extraction Plant was also described along with the Redwater Olefins Fractionator and its potential for salt cavern storage and distribution. It was noted that Alberta is well positioned for polypropylene production because it already has a secure supply and an excellent distribution network. tabs., figs.
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International Nuclear Information System (INIS)
Chappell, D.
2004-01-01
Edmonton-based Williams Energy Canada Inc. extracts petrochemicals from oil sands and operates a straddle plant business and an olefins business. This presentation provided an update of both businesses and reviewed the advantage of polypropylene production in Alberta, with reference to premium markets and to comparative rail costs to Chicago via Texas, and rail costs to Chicago from Alberta. Williams' straddle plant business includes the Cochrane Straddle Plant, the Empress 2 Straddle Plant, and the Empress 5 Straddle Plant. The Fort McMurray Extraction Plant was also described along with the Redwater Olefins Fractionator and its potential for salt cavern storage and distribution. It was noted that Alberta is well positioned for polypropylene production because it already has a secure supply and an excellent distribution network. tabs., figs
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Energy Technology Data Exchange (ETDEWEB)
Gonzalez M, J. L.; Rivero G, T.; Sainz M, E., E-mail: joseluis.gonzalez@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)
2014-10-15
Due to the obsolescence of the instrumentation and control system of the nuclear research reactor IAN-R1, the Institute of Geology and Mining of Colombia, IngeoMinas, launched an international convoking for renewal it which was won by the Instituto Nacional de Investigaciones Nucleares (ININ). Within systems to design, the reactor protection system is described as important for safety, because this carried out, among others two primary functions: 1) ensuring the reactor shutdown safely, and 2) controlling the interlocks to protect against operational errors if defined conditions have not been met. To fulfill these functions, the various subsystems related to the safety report the state in which they are using binary signals and are connected to the inputs of two redundant logic wiring circuits called action logics (Al) that are part of the reactor protection system. These Al also serve as logical interface to indicate at all times the status of subsystems, both the operator and other systems. In the event that any of the subsystems indicates a state of insecurity in the reactor, the Al generate signals off (or scram) of the reactor, maintaining the interlock until the operator sends a reset signal. In this paper the design, implementation, verification and testing of circuits that make up the Al 1 and 2 of IAN-R1 reactor is described, considering the fulfillment of the requirements that the different international standards imposed on this type of design. (Author)
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Directory of Open Access Journals (Sweden)
Christian eLinke
2013-07-01
Full Text Available The Forkhead box family of transcription factors is evolutionary conserved from yeast to higher eukaryotes and its members are involved in many physiological processes including metabolism, DNA repair, cell cycle, stress resistance, apoptosis and aging. In budding yeast, four Forkhead transcription factors were identified, namely Fkh1, Fkh2, Fhl1, and Hcm1, which are implicated in chromatin silencing, cell cycle regulation and stress response. These factors impinge transcriptional regulation during cell cycle progression, and histone deacetylases play an essential role in this process, e.g. the nuclear localisation of Hcm1 depends on Sir2 activity, whereas Sin3/Rpd3 silence cell cycle specific gene transcription in G2/M phase. However, a direct involvement of Sir2 in Fkh1/Fkh2-dependent regulation of target genes is at present unknown. Here, we show that Fkh1 and Fkh2 associate with Sir2 in G1 and M phase, and that Fkh1/Fkh2-mediated activation of reporter genes is antagonized by Sir2. We further report that Sir2 overexpression strongly affects cell growth in an Fkh1/Fkh2-dependent manner. In addition, Sir2 regulates the expression of the mitotic cyclin Clb2 through Fkh1/Fkh2-mediated binding to the CLB2 promoter in G1 and M phase. We finally demonstrate that Sir2 is also enriched at the CLB2 promoter under stress conditions, and that the nuclear localization of Sir2 is dependent on Fkh1 and Fkh2. Taken together, our results show a functional interplay between Fkh1/Fkh2 and Sir2 suggesting a novel mechanism of cell cycle repression. Thus, in budding yeast, not only the regulation of G2/M gene expression but also the protective response against stress could be directly coordinated by Fkh1 and Fkh2.
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Williams-Beuren's Syndrome: A Case Report.
Zamani, Hassan; Babazadeh, Kazem; Fattahi, Saeid; Mokhtari-Esbuie, Farzad
2012-01-01
Williams-Beuren syndrome is a rare familial multisystem disorder occurring in 1 per 20,000 live births. It is characterized by congenital heart defects (CHD), skeletal and renal anomalies, cognitive disorder, social personality disorder and dysmorphic facies. We present a case of Williams syndrome that presented to us with heart murmur and cognitive problem. A 5-year-old girl referred to pediatric cardiologist because of heart murmurs. She had a systolic murmur (2-3/6) in right upper sternal border with radiation to right cervical region. She also had a bulge forehead. Angiography showed mild supra valvular aortic stenosis and mild multiple peripheral pulmonary stenosis. Fluorescent in situ hybridization (FISH) was performed and the result was: 46.XX, ish del (7q11.2) (ELN X1) (7q22 X2) ELN deletion compatible with Williams syndrome. Peripheral pulmonary artery stenosis is associated with Noonan syndrome, Alagille syndrome, Cutis laxa, Ehler-Danlos syndrome, and Silver-Russel syndrome. The patient had peripheral pulmonary artery stenosis, but no other signs of these syndromes were present, and also she had a supravalvular aortic stenosis which was not seen in other syndromes except Williams syndrome. Conclusion. According to primary symptoms, paraclinical and clinical finding such as dysmorphic facies, cognitive disorder and congenital heart defect, Williams syndrome was the first diagnosis. We suggest a more attention for evaluating heart murmur in childhood period, especially when the patient has abnormal facial features or mental problem.
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Williams-Beuren's Syndrome: A Case Report
Directory of Open Access Journals (Sweden)
Hassan Zamani
2012-01-01
Full Text Available Williams-Beuren syndrome is a rare familial multisystem disorder occurring in 1 per 20,000 live births. It is characterized by congenital heart defects (CHD, skeletal and renal anomalies, cognitive disorder, social personality disorder and dysmorphic facies. We present a case of Williams syndrome that presented to us with heart murmur and cognitive problem. A 5-year-old girl referred to pediatric cardiologist because of heart murmurs. She had a systolic murmur (2-3/6 in right upper sternal border with radiation to right cervical region. She also had a bulge forehead. Angiography showed mild supra valvular aortic stenosis and mild multiple peripheral pulmonary stenosis. Fluorescent in situ hybridization (FISH was performed and the result was: 46.XX, ish del (7q11.2 (ELN X1 (7q22 X2 ELN deletion compatible with Williams syndrome. Peripheral pulmonary artery stenosis is associated with Noonan syndrome, Alagille syndrome, Cutis laxa, Ehler-Danlos syndrome, and Silver-Russel syndrome. The patient had peripheral pulmonary artery stenosis, but no other signs of these syndromes were present, and also she had a supravalvular aortic stenosis which was not seen in other syndromes except Williams syndrome. Conclusion. According to primary symptoms, paraclinical and clinical finding such as dysmorphic facies, cognitive disorder and congenital heart defect, Williams syndrome was the first diagnosis. We suggest a more attention for evaluating heart murmur in childhood period, especially when the patient has abnormal facial features or mental problem.
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Sir James Reid and the Death of Queen Victoria: An Early Model for End-of-Life Care.
Abrams, Robert C
2015-12-01
An appraisal of the last ten days of Queen Victoria's life, viewed primarily from the perspective of her personal physician, Sir James Reid, is presented. Sir James' clinical encounters with his patient and the Royal Family are examined to reveal his strategic and medical thinking and gauge his level of success in basic palliative aims. It was found that the lack of effective medical interventions, tensions within the Royal Family, the importance of his post to Sir James' professional career, and the political ramifications unavoidably connected with the illness of a head of state, all presented challenges to Reid's efforts to ease the physical and emotional pain of Queen Victoria's dying. Key features of Sir James' approach included reliance on physician-patient and physician-family relationships, emphasis on emotional support for the patient, and the careful selection of interventions for the family. In the first years of the 20th century, an era when the contemporary concepts of palliative care, hospice, and family dynamics did not exist, Sir James' management of the Queen's final illness suggested an early model for end-of-life care. By the end of Queen Victoria's life, Sir James was seen to have preserved his patient's comfort and dignity, at the same time advancing family and societal acceptance of the death of this matriarchal figure. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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American views of Sir Victor Horsley in the era of Cushing.
Lehner, Kurt R; Schulder, Michael
2018-03-09
Sir Victor Horsley was a pioneering British neurosurgeon known for his numerous neurosurgical, scientific, and sociopolitical contributions. Although word of these surgical and scientific achievements quickly spread throughout Europe and North America in the late 19th century, much of modern neurosurgery's view of Horsley has been colored by a single anecdote from John Fulton's biography of Harvey Cushing. In this account, Cushing observes a frenetic Horsley hastily removing a Gasserian ganglion from a patient in the kitchen of a British mansion. Not long after, Cushing left Britain saying that he had little to learn from British neurosurgery. The authors of this paper examined contemporary views of Horsley to assess what his actual reputation was in the US and Canada. The authors conducted a thorough search of references to Horsley using the following sources: American surgical and neurosurgical textbooks; major biographies; diary entries and letters; PubMed; newspaper articles; and surgical and neurosurgical texts. The positive reception of his work is corroborated by invitations for Horsley to speak in America. Research additionally revealed that Horsley had numerous personal and professional relationships with prominent Americans in medicine, including William Osler, John Wheelock Elliot, Ernest Sachs, and (yes) Harvey Cushing. Horsley's contributions to medicine and science were heavily reported in American newspapers; outside of neurosurgery, his strong opposition to the antivivisectionists and his support for alcohol prohibition were widely reported in popular media. Horsley's contributions to neurosurgery in America are undeniable. Writings from and about prominent Americans reveal that he was viewed favorably by those who had met him. Frequent publication of his views in the American media suggests that medical professionals and the public in the US valued his contributions on scientific as well as social issues. Horsley died too young, but not without the
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Circuits design of action logics of the protection system of nuclear reactor IAN-R1 of Colombia
International Nuclear Information System (INIS)
Gonzalez M, J. L.; Rivero G, T.; Sainz M, E.
2014-10-01
Due to the obsolescence of the instrumentation and control system of the nuclear research reactor IAN-R1, the Institute of Geology and Mining of Colombia, IngeoMinas, launched an international convoking for renewal it which was won by the Instituto Nacional de Investigaciones Nucleares (ININ). Within systems to design, the reactor protection system is described as important for safety, because this carried out, among others two primary functions: 1) ensuring the reactor shutdown safely, and 2) controlling the interlocks to protect against operational errors if defined conditions have not been met. To fulfill these functions, the various subsystems related to the safety report the state in which they are using binary signals and are connected to the inputs of two redundant logic wiring circuits called action logics (Al) that are part of the reactor protection system. These Al also serve as logical interface to indicate at all times the status of subsystems, both the operator and other systems. In the event that any of the subsystems indicates a state of insecurity in the reactor, the Al generate signals off (or scram) of the reactor, maintaining the interlock until the operator sends a reset signal. In this paper the design, implementation, verification and testing of circuits that make up the Al 1 and 2 of IAN-R1 reactor is described, considering the fulfillment of the requirements that the different international standards imposed on this type of design. (Author)
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SIR - small is safe [in reactor design
International Nuclear Information System (INIS)
Hayns, M.
1989-01-01
A joint USA-UK venture has been initiated to design a small nuclear reactor which offers low capital cost, greater flexibility and a potentially lower environmental impact. Called Safe Integral Reactor (SIR), the lead unit could be built in the United Kingdom Atomic Energy Authority's (UKAEA's) Winfrith site if the design is accepted by the UK Nuclear Installations Inspectorate (NII). This article describes the 320 MWe reactor unit that is the basis of the design being developed. (author)
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Wu, S.-T.
1985-01-01
Seasonally compatible data collected by SIR-A and by Landsat 4 TM over the lower coastal plain in Alabama were coregistered, forming a SIR-A/TM multichannel data set with 30 m x 30 m pixel size. Spectral signature plots and histogram analysis of the data were used to observe data characteristics. Radar returns from pine forest classes correlated highly with the tree ages, suggesting the potential utility of microwave remote sensing for forest biomass estimation. As compared with the TM-only data set, the use of SIR-A/TM data set improved classification accuracy of the seven land cover types studied. In addition, the SIR-A/TM classified data support previous finding by Engheta and Elachi (1982) that microwave data appear to be correlated with differing bottomland hardwood forest vegetation as associated with varying water regimens (i.e., wet versus dry).
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Gregoric, Pavle; Pavle, Gregoric; Sijacki, Ana; Ana, Sijacki; Stankovic, Sanja; Sanja, Stankovic; Radenkovic, Dejan; Dejan, Radenkovic; Ivancevic, Nenad; Nenad, Ivancevic; Karamarkovic, Aleksandar; Aleksandar, Karamarkovic; Popovic, Nada; Nada, Popovic; Karadzic, Borivoje; Borivoje, Karadzic; Stijak, Lazar; Stefanovic, Branislav; Branislav, Stefanovic; Milosevic, Zoran; Zoran, Milosević; Bajec, Djordje; Djordje, Bajec
2010-01-01
Early recognition of severe form of acute pancreatitis is important because these patients need more agressive diagnostic and therapeutical approach an can develope systemic complications such as: sepsis, coagulopathy, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Dysfunction Syndrome (MODS), Multiple Organ Failure (MOF). To determine role of the combination of Systemic Inflammatory Response Syndrome (SIRS) score and serum Interleukin-6 (IL-6) level on admission as predictor of illness severity and outcome of Severe Acute Pancreatitis (SAP). We evaluated 234 patients with first onset of SAP appears in last twenty four hours. A total of 77 (33%) patients died. SIRS score and serum IL-6 concentration were measured in first hour after admission. In 105 patients with SIRS score 3 and higher, initial measured IL-6 levels were significantly higher than in the group of remaining 129 patients (72 +/- 67 pg/mL, vs 18 +/- 15 pg/mL). All nonsurvivals were in the first group, with SIRS score 3 and 4 and initial IL-6 concentration 113 +/- 27 pg/mL. The values of C-reactive Protein (CRP) measured after 48h, Acute Physiology and Chronic Health Evaluation (APACHE II) score on admission and Ranson score showed the similar correlation, but serum amylase level did not correlate significantly with Ranson score, IL-6 concentration and APACHE II score. The combination of SIRS score on admission and IL-6 serum concentration can be early, predictor of illness severity and outcome in SAP.
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Geary, L
2016-05-01
This essay attempts to assess William Wilde as a social historian. It examines some of his contributions to the discipline of history and looks particularly at 'The food of the Irish', which was published in the Dublin University Magazine in February 1854.
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Language and Communicative Development in Williams Syndrome
Mervis, Carolyn B.; Becerra, Angela M.
2007-01-01
Williams syndrome, a genetic disorder caused by a microdeletion of approximately 25 genes on chromosome 7q11.23, is associated with mild to moderate intellectual disability or learning difficulties. Most individuals with Williams syndrome evidence a cognitive profile including relative strengths in verbal short-term memory and language, and…
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75 FR 39910 - Prince William Sound Resource Advisory Committee; Meeting
2010-07-13
... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee; Meeting AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource..., Anchorage, Alaska 99503. Send written comments to Prince William Sound Resource Advisory Committee, c/o USDA...
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Social Cognition in Williams Syndrome: Face Tuning.
Pavlova, Marina A; Heiz, Julie; Sokolov, Alexander N; Barisnikov, Koviljka
2016-01-01
Many neurological, neurodevelopmental, neuropsychiatric, and psychosomatic disorders are characterized by impairments in visual social cognition, body language reading, and facial assessment of a social counterpart. Yet a wealth of research indicates that individuals with Williams syndrome exhibit remarkable concern for social stimuli and face fascination. Here individuals with Williams syndrome were presented with a set of Face-n-Food images composed of food ingredients and in different degree resembling a face (slightly bordering on the Giuseppe Arcimboldo style). The primary advantage of these images is that single components do not explicitly trigger face-specific processing, whereas in face images commonly used for investigating face perception (such as photographs or depictions), the mere occurrence of typical cues already implicates face presence. In a spontaneous recognition task, participants were shown a set of images in a predetermined order from the least to most resembling a face. Strikingly, individuals with Williams syndrome exhibited profound deficits in recognition of the Face-n-Food images as a face: they did not report seeing a face on the images, which typically developing controls effortlessly recognized as a face, and gave overall fewer face responses. This suggests atypical face tuning in Williams syndrome. The outcome is discussed in the light of a general pattern of social cognition in Williams syndrome and brain mechanisms underpinning face processing.
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A new case of keratoconus associated with Williams-Beuren syndrome.
Viana, Melissa Machado; Frasson, Maria; Leão, Letícia Lima; Stofanko, Martin; Gonçalves-Dornelas, Higgor; Cunha, Pricila da Silva; de Aguiar, Marcos José Burle
2013-09-01
Williams-Beuren syndrome is a multisystemic genetic disorder caused by a contiguous gene deletion at 7q11.23. Keratoconus is a complex disease and it is suspected to have a genetic origin, although the specific gene responsible for keratoconus has not been identified. Although there are several ocular features in Williams-Beuren syndrome, keratoconus is not regularly described as part of this syndrome. To report a new patient with keratoconus and Williams-Beuren syndrome. This is the third case of an association between Williams-Beuren syndrome and keratoconus. The authors believe that the Williams-Beuren syndrome chromosome region can be a possible target for further investigation as the genetic basis of keratoconus.
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Directory of Open Access Journals (Sweden)
Alison E Ringel
Full Text Available Sir2 is an NAD(+-dependent histone deacetylase required to mediate transcriptional silencing and suppress rDNA recombination in budding yeast. We previously identified Tdh3, a glyceraldehyde 3-phosphate dehydrogenase (GAPDH, as a high expression suppressor of the lethality caused by Sir2 overexpression in yeast cells. Here we show that Tdh3 interacts with Sir2, localizes to silent chromatin in a Sir2-dependent manner, and promotes normal silencing at the telomere and rDNA. Characterization of specific TDH3 alleles suggests that Tdh3's influence on silencing requires nuclear localization but does not correlate with its catalytic activity. Interestingly, a genetic assay suggests that Tdh3, an NAD(+-binding protein, influences nuclear NAD(+ levels; we speculate that Tdh3 links nuclear Sir2 with NAD(+ from the cytoplasm.
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Epistemologia pragmatyczna Michaela Williamsa (PRAGMATIST EPISTEMOLOGY BY MICHAEL WILLIAMS
Directory of Open Access Journals (Sweden)
Renata Ziemińska
2007-06-01
Full Text Available The article presents three main elements of Williams' epistemology: the concept of knowledge, the problem of skepticism and the concept of truth. Williams takes knowledge not as pure descriptive but partly normative concept (to know is to be engaged and entitled. He rejects the demonstrative conception of knowledge (knowledge is infallible and prefers the fallibilist conception of knowledge (knowledge is uncertain and fallible. Williams is good at bringing skeptical presuppositions to light: the demonstrative conception of knowledge and the conception of justification with Prior Grounding Requirement, epistemological realism and priority for internal knowledge. He rightly observes that when we change that presuppositions (skeptic's context, knowledge does exist. However, Williams-fallibilist is close to a skeptic: they both agree that our beliefs are uncertain. The difference is only whether some of our beliefs deserve to be called knowledge. The most important worries concern Williams' concept of truth (deflationary pragmatism. According to Williams truth has no nature and it is not a goal of inquiry. However, if truth is not a goal, we can hardly understand the previous discussion with skepticism and the defense of rationality.
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Investigating The Travelling Wave Solution For an SIR Endemic ...
African Journals Online (AJOL)
This paper presents the travelling wave solution for an SIR endemic disease model with no disease related death when the spatial spread of the susceptible is not negligible. In this case the disease is driven by both the susceptible and the infective classes. The population is open since the disease is habitually prevalent in ...
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Science and controversy a biography of Sir Norman Lockyer
Meadows, A
2008-01-01
Sir Norman Lockyer left Nature, the world''s leading scientific journal, as his lasting memorial. But his life, and controversial theories, are an important part of science history. His ideas were at the forefront of public debate, and ranged from brilliant to perverse. This entertaining book is a fascinating insight into his eventful life
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33 CFR 161.60 - Vessel Traffic Service Prince William Sound.
2010-07-01
... William Sound. 161.60 Section 161.60 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Movement Reporting System Areas and Reporting Points § 161.60 Vessel Traffic Service Prince William Sound... Cape Hinchinbrook Light to Schooner Rock Light, comprising that portion of Prince William Sound between...
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Buffels (Wes), Elsies, Sir Lowry's pass, Steenbras and Buffels (Oos)
CSIR Research Space (South Africa)
Heinecken, TJE
1982-06-01
Full Text Available This report is a synthesis of all available information on five of the smaller rivers discharging in to False bay combined as a single volume. The rivers dealt with are the Buffels (Wes), Elsies, Sir Lowry' Pass, Steenbras and Buffels (Oos). False...
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Skin findings in Williams syndrome.
Kozel, Beth A; Bayliss, Susan J; Berk, David R; Waxler, Jessica L; Knutsen, Russell H; Danback, Joshua R; Pober, Barbara R
2014-09-01
Previous examination in a small number of individuals with Williams syndrome (also referred to as Williams-Beuren syndrome) has shown subtly softer skin and reduced deposition of elastin, an elastic matrix protein important in tissue recoil. No quantitative information about skin elasticity in individuals with Williams syndrome is available; nor has there been a complete report of dermatologic findings in this population. To fill this knowledge gap, 94 patients with Williams syndrome aged 7-50 years were recruited as part of the skin and vascular elasticity (WS-SAVE) study. They underwent either a clinical dermatologic assessment by trained dermatologists (2010 WSA family meeting) or measurement of biomechanical properties of the skin with the DermaLab™ suction cup (2012 WSA family meeting). Clinical assessment confirmed that soft skin is common in this population (83%), as is premature graying of the hair (80% of those 20 years or older), while wrinkles (92%), and abnormal scarring (33%) were detected in larger than expected proportions. Biomechanical studies detected statistically significant differences in dP (the pressure required to lift the skin), dT (the time required to raise the skin through a prescribed gradient), VE (viscoelasticity), and E (Young's modulus) relative to matched controls. The RT (retraction time) also trended longer but was not significant. The biomechanical differences noted in these patients did not correlate with the presence of vascular defects also attributable to elastin insufficiency (vascular stiffness, hypertension, and arterial stenosis) suggesting the presence of tissue specific modifiers that modulate the impact of elastin insufficiency in each tissue. © 2014 Wiley Periodicals, Inc.
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Simulation of emotional contagion using modified SIR model: A cellular automaton approach
Fu, Libi; Song, Weiguo; Lv, Wei; Lo, Siuming
2014-07-01
Emotion plays an important role in the decision-making of individuals in some emergency situations. The contagion of emotion may induce either normal or abnormal consolidated crowd behavior. This paper aims to simulate the dynamics of emotional contagion among crowds by modifying the epidemiological SIR model to a cellular automaton approach. This new cellular automaton model, entitled the “CA-SIRS model”, captures the dynamic process ‘susceptible-infected-recovered-susceptible', which is based on SIRS contagion in epidemiological theory. Moreover, in this new model, the process is integrated with individual movement. The simulation results of this model show that multiple waves and dynamical stability around a mean value will appear during emotion spreading. It was found that the proportion of initial infected individuals had little influence on the final stable proportion of infected population in a given system, and that infection frequency increased with an increase in the average crowd density. Our results further suggest that individual movement accelerates the spread speed of emotion and increases the stable proportion of infected population. Furthermore, decreasing the duration of an infection and the probability of reinfection can markedly reduce the number of infected individuals. It is hoped that this study will be helpful in crowd management and evacuation organization.
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Discoverers of the universe William and Caroline Herschel
Hoskin, Michael
2011-01-01
Discoverers of the Universe tells the gripping story of William Herschel, the brilliant, fiercely ambitious, emotionally complex musician and composer who became court astronomer to Britain's King George III, and of William's sister, Caroline, who assisted him in his observations of the night sky and became an accomplished astronomer in her own right. Together, they transformed our view of the universe from the unchanging, mechanical creation of Newton's clockmaker god to the ever-evolving, incredibly dynamic cosmos that it truly is. William was in his forties when his amateur observations usi
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Clear as Crystal: The Story of the Braggs--How X-Ray Crystallography Has Contributed to Science
George, Robert; Patterson, John
2014-01-01
Here is a brief history of the work of two of Australia's most famous scientists, Sir William Bragg and his son Sir Lawrence Bragg. Jointly awarded the Nobel Prize in 1915 for their groundbreaking research into the use of X-rays to study the chemical structure and function of molecules, they have contributed to our heritage and to science at an…
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INFORMAÇÕES SOBRE GESTÃO DE RISCOS NAS IANs DAS EMPRESAS LISTADAS NO NOVO MERCADO DA BOVESPA
Directory of Open Access Journals (Sweden)
Francisco Carlos Fernandes
2008-01-01
Full Text Available Las mejores prácticas de gobierno corporativo previenen que la gestión de la empresa conozca los riesgos asumidos y que los inversionistas sean informados sobre ellos. Este trabajo tiene como objetivo levantar las prácticas de divulgación sobre riesgos adoptadas en las Informaciones Anuales (IANs de las empresas. Se presenta un análisis del con - tenido de estos instrumentos de comunicación de las empresas clasificadas en el nivel de gobierno del Nuevo Mercado de la Bovespa. La metodología de la pesquisa aplicada se caracteriza como descriptiva y cualitativa, empleando como método el análisis docu - mental. Los resultados muestran que 73 de las 99 empresas del Nuevo Mercado habían divulgado sus IANs hasta 31.05.08, siendo que 12 de ellas nada relatan sobre su políticas de gestión de riesgos y de las 61 restantes apenas 6 presentan un apartado especifico sobre gestión de riesgo en sus informes. El análisis de contenido muestra que las empre-sas que adoptan las mejores prácticas ofrecen diversas informaciones sobre gestión de riesgo, incluyendo estructura organizacional, técnicas utilizadas y políticas de protección. Se concluye que los reportes sobre riesgos de la mayoría de las empresas aún presentan niveles bajos de evidencia.
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Le continent noir du désir masculin : Colet et Flaubert, encore
Vinken, Barbara
2010-01-01
Il y a peu d’échanges de lettres qui surprennent le lecteur aussi douloureusement que celui entre Louise Colet et Gustave Flaubert. Rarement, l’espoir qui sommeille au fond de tout lecteur d’une histoire d’amour heureux fut à ce point frustré.Les études de Freud – un des plus grands sceptiques en matière d’amour – sur la vie sexuelle éclairent les vicissitudes du désir amoureux masculin. Les Lettres de Flaubert à Colet sont la mise en scène dramatique d’un désir qui suit les complications du ...
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Investigating the ''social brain'' through Williams syndrome
International Nuclear Information System (INIS)
Nagamine, Masanori; Mimura, Masaru; Reiss, A.L.; Hoeft, F.
2010-01-01
Recent advances in social cognitive neuroscience have led to the concept of the ''social brain''. The social brain includes neural processes specialized for processing social information necessary for the recognition of self and others, and interpersonal relationships. Because of its unique behavioral phenotypic features which includes 'hypersociability', Williams syndrome has gained popularity among social cognitive neuroscientists. Individuals with Williams syndrome share the same genetic risk factor for cognitive-behavioral dysfunction utilizing brain imaging to elucidate endophenotype provides us with an unprecendented opportunity to study gene, brain and behavior relationships especially those related to social cognition. In this review, we provide an overview of neuroimaging studies on social cognition in Williams syndrome and discuss the neural basis of the social brain. (author)
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The William and Flora Hewlett Foundation | IDRC - International ...
International Development Research Centre (IDRC) Digital Library (Canada)
The William and Flora Hewlett Foundation. The William and Flora Hewlett Foundation. http://www.hewlett.org/. Think Tank Initiative. This initiative is creating high-quality independent research and policy institutions throughout the developing world. View more. Think Tank Initiative. Growth and Economic Opportunities for ...
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Mental Health Problems in Adults with Williams Syndrome
Stinton, Chris; Elison, Sarah; Howlin, Patricia
2010-01-01
Although many researchers have investigated emotional and behavioral difficulties in individuals with Williams syndrome, few have used standardized diagnostic assessments. We examined mental health problems in 92 adults with Williams syndrome using the Psychiatric Assessment Schedule for Adults with Developmental Disabilities--PAS-ADD (Moss,…
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Concepts, Diagnosis and the History of Medicine: Historicising Ian Hacking and Munchausen Syndrome.
Millard, Chris
2017-08-01
Concepts used by historians are as historical as the diagnoses or categories that are studied. The example of Munchausen syndrome (deceptive presentation of illness in order to adopt the 'sick role') is used to explore this. Like most psychiatric diagnoses, Munchausen syndrome is not thought applicable across time by social historians of medicine. It is historically specific, drawing upon twentieth-century anthropology and sociology to explain motivation through desire for the 'sick role'. Ian Hacking's concepts of 'making up people' and 'looping effects' are regularly utilised outside of the context in which they are formed. However, this context is precisely the same anthropological and sociological insight used to explain Munchausen syndrome. It remains correct to resist the projection of Munchausen syndrome into the past. However, it seems inconsistent to use Hacking's concepts to describe identity formation before the twentieth century as they are given meaning by an identical context.
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34 CFR 685.100 - The William D. Ford Federal Direct Loan Program.
2010-07-01
... 34 Education 3 2010-07-01 2010-07-01 false The William D. Ford Federal Direct Loan Program. 685...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION WILLIAM D. FORD FEDERAL DIRECT LOAN PROGRAM Purpose and Scope § 685.100 The William D. Ford Federal Direct Loan Program. (a) Under the William D. Ford...
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Congenital heart defects in Williams syndrome.
Yuan, Shi-Min
2017-01-01
Yuan SM. Congenital heart defects in Williams syndrome. Turk J Pediatr 2017; 59: 225-232. Williams syndrome (WS), also known as Williams-Beuren syndrome, is a rare genetic disorder involving multiple systems including the circulatory system. However, the etiologies of the associated congenital heart defects in WS patients have not been sufficiently elucidated and represent therapeutic challenges. The typical congenital heart defects in WS were supravalvar aortic stenosis, pulmonary stenosis (both valvular and peripheral), aortic coarctation and mitral valvar prolapse. The atypical cardiovascular anomalies include tetralogy of Fallot, atrial septal defects, aortic and mitral valvular insufficiencies, bicuspid aortic valves, ventricular septal defects, total anomalous pulmonary venous return, double chambered right ventricle, Ebstein anomaly and arterial anomalies. Deletion of the elastin gene on chromosome 7q11.23 leads to deficiency or abnormal deposition of elastin during cardiovascular development, thereby leading to widespread cardiovascular abnormalities in WS. In this article, the distribution, treatment and surgical outcomes of typical and atypical cardiac defects in WS are discussed.
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Recent paleoseismicity record in Prince William Sound, Alaska, USA
Kuehl, Steven A.; Miller, Eric J.; Marshall, Nicole R.; Dellapenna, Timothy M.
2017-12-01
Sedimentological and geochemical investigation of sediment cores collected in the deep (>400 m) central basin of Prince William Sound, along with geochemical fingerprinting of sediment source areas, are used to identify earthquake-generated sediment gravity flows. Prince William Sound receives sediment from two distinct sources: from offshore (primarily Copper River) through Hinchinbrook Inlet, and from sources within the Sound (primarily Columbia Glacier). These sources are found to have diagnostic elemental ratios indicative of provenance; Copper River Basin sediments were significantly higher in Sr/Pb and Cu/Pb, whereas Prince William Sound sediments were significantly higher in K/Ca and Rb/Sr. Within the past century, sediment gravity flows deposited within the deep central channel of Prince William Sound have robust geochemical (provenance) signatures that can be correlated with known moderate to large earthquakes in the region. Given the thick Holocene sequence in the Sound ( 200 m) and correspondingly high sedimentation rates (>1 cm year-1), this relationship suggests that sediments within the central basin of Prince William Sound may contain an extraordinary high-resolution record of paleoseismicity in the region.
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BOREAS RSS-15 SIR-C and Landsat TM Biomass and Landcover Maps of the NSA
Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Ranson, K. Jon
2000-01-01
As part of BOREAS, the RSS-15 team conducted an investigation using SIR-C, X-SAR, and Landsat TM data for estimating total above-ground dry biomass for the SSA and NSA modeling grids and component biomass for the SSA. Relationships of backscatter to total biomass and total biomass to foliage, branch, and bole biomass were used to estimate biomass density across the landscape. The procedure involved image classification with SAR and Landsat TM data and development of simple mapping techniques using combinations of SAR channels. For the SSA, the SIR-C data used were acquired on 06-Oct-1994, and the Landsat TM data used were acquired on 02-Sep-1995. The maps of the NSA were developed from SIR-C data acquired on 13-Apr-1994. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).
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Emotional Responsivity in Young Children with Williams Syndrome
Fidler, Debbie J.; Hepburn, Susan L.; Most, David E.; Philofsky, Amy; Rogers, Sally J.
2007-01-01
The hypothesis that young children with Williams syndrome show higher rates of emotional responsivity relative to other children with developmental disabilities was explored. Performance of 23 young children with Williams syndrome and 30 MA-matched children with developmental disabilities of nonspecific etiologies was compared on an adaptation of…
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Malformations vasculaires au cours du syndrome de Williams ...
African Journals Online (AJOL)
Le syndrome de Williams-Beuren est une maladie génétique rare, il associe classiquement une dysmorphie faciale assez spécifique, des malformations cardiovasculaires et un profil neuropsychologique particulier. Nous rapportons les observations de trois enfants atteints du syndrome de Williams-Beuren en insistant ...
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William Carlos Williams’ cubism: The sensory dimension
Directory of Open Access Journals (Sweden)
J-L Kruger
1995-05-01
Full Text Available In this article the cubism of the American poet William Carlos Williams is discussed as a product of sensory elements combined with techniques derived from the work of the visual artists associated with this style. Through the study o f a number of poems written in the period between 1917 and 1923 it is shown that Williams employs the cubist intersection of sensory planes in particular to create a sensory dimension that not only renews the traditions and mode of poetry, but also reveals the cubist concern with the defamiliarization and foregrounding of fragments of everyday experiences. Ultimately the article is an attempt to indicate Williams’ incorporation o f a sensual dimension in creating a style that achieves modernist presentation revealing an independence from both traditional literary and visual styles.
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International Nuclear Information System (INIS)
Forwood, Nicholas J.; Pocock, Nicholas; Shin, Jane; Young, Andy M; Szeto, Edwin R.
2009-01-01
Full text: Background: In clinical practice the dose of Y 9 0 Sir-Spheres is calculated using a pre injection of Tc 9 9 m MAA. There is however a potential difference due to the different properties of Tc 9 9 m MAA and Y 9 0 Sir-Spheres. We assessed the concordance of lung shunting of Y 9 0 Sir-Spheres estimated using Y 9 0 Bremsstrahlung imaging, compared to shunting assessed using Tc 9 9 m MAA. Methods: 15 Patients were evaluated using 150-200 MBq of Tc 9 9 m MAA injected into the hepatic artery under angiographic guidance. Whole body images were acquired using a LEAP collimator (window of 140 kEv+/-10%). The patients were subsequently treated with Y 9 0 Sir-Spheres. After microspheres injection, whole body brehmsstrahlung images were acquired using a medium energy collimator (window settings of 75 kEv +/- 20%). Tc 9 9 m MAA images were paired with their corresponding bremsstrahlung image and lung shunting in the stu ides calculated simultaneously. Each paired dataset was analyzed by 5 operators. Results: The mean lung shunting for Tc 9 9 m MAA acquisition was 3.32% (SD 2.03) which was significantly lower than the lung shunting using the Y 9 0 acquisitions: mean 16.19% (SD of 6.43). The Pearson coefficient was r = 0.62 (p 9 0 Sir-Spheres bremsstrahlung imaging is higher than that calculated by Tc 9 9 m MAA imaging. The relationship is not sufficiently strong to use bremsstahlung imaging to retrospectively quantify the lung-to-liver shunting as indicated using Tc 9 9 M AA. Further studies are underway to assess the reliability of Tc 9 9 m MAA lung uptake calculations in determining the dose of Y 9 0 Sir-Spheres.
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Infantile ictal apneas in a child with williams-beuren syndrome.
Myers, Kenneth A; McLeod, D Ross; Bello-Espinosa, Luis
2013-02-01
Williams-Beuren syndrome is a genetic disorder rarely associated with seizures. The few described cases of Williams-Beuren syndrome and epilepsy have primarily involved infantile spasms and deletions extending beyond the common deletion region for this disorder. We present the case of a 5-week-old child with ictal apneas and typical Williams-Beuren syndrome deletion. Diagnosis was challenging, because the child had cardiac, respiratory, and gastrointestinal abnormalities typically associated with Williams-Beuren syndrome, which are also associated with cyanotic episodes. The results of interictal electroencephalography were normal, illustrating that prolonged electroencephalography is often essential in evaluation of suspected ictal apneas. Seizure freedom was achieved with carbamazepine. Sudden death is seen in Williams-Beuren syndrome, and this case raises the question whether some of these cases may be related to ictal apneas and could potentially be preventable with appropriate pharmaceutical intervention. Copyright © 2013 Elsevier Inc. All rights reserved.
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Milestones in plant sulfur research on sulfur-induced-resistance (SIR in Europe
Directory of Open Access Journals (Sweden)
Elke eBloem
2015-01-01
Full Text Available Until the 1970´s of the last century sulfur (S was mainly regarded as a pollutant being the main contributor of acid rain, causing forest dieback in central Europe. When Clean Air Acts came into force at the start of the 1980´s SO2 contaminations in the air were consequently reduced within the next years. S changed from an unwanted pollutant into a lacking plant nutrient in agriculture since agricultural fields were no longer fertilized indirectly by industrial pollution. S deficiency was first noticed in Brassica crops that display an especially high S demand because of its content of S-containing secondary metabolites, the glucosinolates. In Scotland, where S depositions decreased even faster than in continental Europe, an increasing disease incidence with Pyrenopeziza brassicae was observed in oilseed rape in the beginning 1990´s and the concept of sulfur-induced-resistance (SIR was developed after a relationship between the S status and the disease incidence was uncovered. Since then a lot of research was carried out to unravel the background of SIR in the metabolism of agricultural crops and to identify metabolites, enzymes and reactions, which are potentially activated by the S metabolism to combat fungal pathogens. The S status of the crop is affecting many different plant features such as color and scent of flowers, pigments in leaves, metabolite concentrations and the release of gaseous S compounds which are directly influencing the desirability of a crop for a variety of different organisms from microorganisms, over insects and slugs to the point of grazing animals.The present paper is an attempt to sum up the knowledge about the effect of the S nutritional status of agricultural crops on parameters that are directly related to their health status and by this to SIR. Milestones in SIR research are compiled, open questions are addressed and future projections were developed.
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Northern gas: Williams petrochemical feasibility study
Energy Technology Data Exchange (ETDEWEB)
Chappell, D. [Williams Energy Canada, Calgary, AB (Canada)
2002-07-01
Williams Energy is a company that is involved in the following fields: gas pipelines, exploration and production, midstream, refining, petrochemical, power, and marketing and trading. The author provides an overview of the global and Canadian infrastructure before proceeding to discuss Arctic gas, which is viewed by Williams Energy as necessary. It favors the Alaska Highway route with a consortium for project development. Williams performed a petrochemical study to determine the feasibility of a petrochemical complex utilizing natural gas liquid from an Arctic gas pipeline. The scope of the study encompassed facilities (extraction plant, cracker, polyolefins plant), size (world scale, approximately 2 billion pounds per year), and location (Fairbanks or Alberta). The study led to the following findings: (1) review of several scenarios for both locations, (2) complex to produce two grades of polyethylene, (3) feedstock cost favors Alaska, (4) construction costs lower in Alberta, (5) and the primary market for the Alaska complex would be northeast Asia, while the primary market for the Alberta location would be the United States. It was determined that both options would be viable, however Alberta was favored due to the polyethylene forecast. The challenges still being faced by Williams include low frac spread, market inefficiencies, empress volumes, carbon dioxide, and fuel and electricity cost. Each of these challenges is discussed separately. The author concludes by indicating that incremental ethane is available, carbon dioxide issues need resolution, and Alberta and Alaska are attractive for Arctic ethane petrochemical production. figs.
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Directory of Open Access Journals (Sweden)
Regis Goulart Rosa
2017-11-01
Full Text Available We compared the discriminatory capacity of the sequential organ failure assessment (SOFA versus the systemic inflammatory response syndrome (SIRS score for predicting ICU mortality, need for and length of mechanical ventilation, ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition and SIRS (SIRS score ≥2 points. From January 2008 to December 2014, 1487 patients were admitted to the ICU due to suspected infection. SOFA ≥2 identified more septic patients than SIRS ≥2 (79.0% [n = 1175] vs. 68.5% [n = 1020], p 7 days (AUROC = 0.65 vs. 0.63, p = 0.004, and length of hospitalization >10 days (AUROC = 0.61 vs. 0.59, p 7 days.
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Celiac disease in patients with Williams-Beuren syndrome.
Mıhçı, Ercan; Nur, Banu Güzel; Berker-Karaüzüm, Sibel; Yılmaz, Aygen; Artan, Reha
2015-01-01
Celiac disease is an autoimmune, gastrointestinal disorder characterized by intolerance to the dietary grain protein gluten. An increased prevalence of celiac disease has been reported in Down syndrome and Turner syndrome, but there has been only few previous reports with respect to the association of celiac disease in Williams-Beuren syndrome. The aim of this study was to evaluate the frequency of celiac disease in our 24 Williams-Beuren syndrome patients. Gastrointestinal problems and celiac disease symptoms of patients were noted. All patients were analyzed by the titer of tissue transglutaminases IgA and IgG. HLA genotyping and intestinal biopsy was performed to the patients with positive serology. We also performed gluten free diet in the presence of compatible symptoms, serology, HLA genotyping and intestinal biopsy. In our study, two patients had positive tTG antibodies, but only one had positive biopsy finding for celiac disease. The frequency of celiac disease in patients with Williams-Beuren syndrome was estimated as 1/24 (4.1%). Though the number of participants in this study was limited, the results show that the frequency of celiac disease is higher in Williams-Beuren syndrome compared to the general population. We suggest that a high suspicion and testing for celiac disease should be recommended at certain intervals in all cases with Williams-Beuren syndrome to detect the cause of growth retardation and gastrointestinal problems.
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Williams Syndrome and 15q Duplication: Coincidence versus Association.
Khokhar, Aditi; Agarwal, Swashti; Perez-Colon, Sheila
2017-01-01
Williams syndrome is a multisystem disorder caused by contiguous gene deletion in 7q11.23, commonly associated with distinctive facial features, supravalvular aortic stenosis, short stature, idiopathic hypercalcemia, developmental delay, joint laxity, and a friendly personality. The clinical features of 15q11q13 duplication syndrome include autism, mental retardation, ataxia, seizures, developmental delay, and behavioral problems. We report a rare case of a girl with genetically confirmed Williams syndrome and coexisting 15q duplication syndrome. The patient underwent treatment for central precocious puberty and later presented with primary amenorrhea. The karyotype revealed 47,XX,+mar. FISH analysis for the marker chromosome showed partial trisomy/tetrasomy for proximal chromosome 15q (15p13q13). FISH using an ELN -specific probe demonstrated a deletion in the Williams syndrome critical region in 7q11.23. To our knowledge, a coexistence of Williams syndrome and 15q duplication syndrome has not been reported in the literature. Our patient had early pubertal development, which has been described in some patients with Williams syndrome. However, years later after discontinuing gonadotropin-releasing hormone analogue treatment, she developed primary amenorrhea.
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Contemporary computational mathematics a celebration of the 80th birthday of Ian Sloan
Kuo, Frances; Woźniakowski, Henryk
2018-01-01
This book is a tribute to Professor Ian Hugh Sloan on the occasion of his 80th birthday. It consists of nearly 60 articles written by international leaders in a diverse range of areas in contemporary computational mathematics. These papers highlight the impact and many achievements of Professor Sloan in his distinguished academic career. The book also presents state of the art knowledge in many computational fields such as quasi-Monte Carlo and Monte Carlo methods for multivariate integration, multi-level methods, finite element methods, uncertainty quantification, spherical designs and integration on the sphere, approximation and interpolation of multivariate functions, oscillatory integrals, and in general in information-based complexity and tractability, as well as in a range of other topics. The book also tells the life story of the renowned mathematician, family man, colleague and friend, who has been an inspiration to many of us. The reader may especially enjoy the story from the perspective of his fami...
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The Relationship between History and Ethics in Ian McEwan’s Black Dogs
Directory of Open Access Journals (Sweden)
Maryam Sedaghat
2014-06-01
Full Text Available The relationship between history and ethics may seem irrelevant at first; however, these two have been related during the long history of war, violence and mass killing. The need of history to ethics is for saving itself from all the violence and terror. Emmanuel Levinas as a philosopher has tried to define ethics in a way that suits the terrible historical condition of humanity in the twentieth century. In his view, ethics is the infinite responsibility towards other human beings. He defines ‘being’ in relation to the ‘other’ who may be a complete stranger. In this definition a person bears complete responsibility toward the other and should answer the other’s call for help. In Ian McEwan's novel Black Dogs the protagonist is exposed to historical legacies of violence, and develops an ethical consciousness until the end of the novel. Responsibility seems to be a good answer to historical mass killing and violence that is dominant in the world.
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McCauley, John F.; Breed, Carlos S.; Schaber, Gerald G.; McHugh, William P.; Issawi, Bahay; Haynes, C. Vance; Grolier, Maurice J.; El Kilani, Ali
1986-01-01
A complex history of Cenozoic fluvial activity in the presently hyperarid eastern Sahara is inferred from Shuttle Imaging Radar (SIR) data and postflight field investigations in southwest Egypt and northwest Sudan. SIR images were coregistered with Landsat and existing maps as a guide to exploration of the buried paleodrainages (radar rivers) first discovered by SIR-A. Field observations explain the radar responses of three types of radar rivers: RR-1, RR-2, and RR-3. A generalized model of the radar rivers, based on field studies and regional geologic relations, shows apparent changes in river regimen since the large valleys were established during the late Paleogene-early Neogene eras. SIR-based mapping of these paleodrainages, although incomplete, reveals missing links in an area once thought to be devoid of master streams.
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Colour discrimination and categorisation in Williams syndrome
Farran, E. K.; Cranwell, M. B.; Alvarez, J.; Franklin, A.
2013-01-01
Individuals with Williams syndrome (WS) present with impaired functioning of the dorsal visual stream relative to the ventral visual stream. As such, little attention has been given to ventral stream functions in WS. We investigated colour processing, a predominantly ventral stream function, for the first time in nineteen individuals with Williams syndrome. Colour discrimination was assessed using the Farnsworth-Munsell 100 hue test. Colour categorisation was assessed using a match-to-sample ...
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76 FR 44893 - Prince William Sound Resource Advisory Committee
2011-07-27
... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource Advisory... District, 145 Forest Station Road, Girdwood, AK; Prince Willam Sound Community College, 303 Lowe Street...
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33 CFR 165.1704 - Prince William Sound, Alaska-regulated navigation area.
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Prince William Sound, Alaska... District § 165.1704 Prince William Sound, Alaska-regulated navigation area. (a) The following is a... Hinchinbrook Light to Schooner Rock Light, comprising that portion of Prince William Sound between 146°30′ W...
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Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia
Energy Technology Data Exchange (ETDEWEB)
Samat, N. A.; Ma' arof, S. H. Mohd Imam [Department of Mathematics, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjung Malim, Perak (Malaysia)
2014-12-04
This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.
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Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia
International Nuclear Information System (INIS)
Samat, N. A.; Ma'arof, S. H. Mohd Imam
2014-01-01
This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases
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Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia
Samat, N. A.; Ma'arof, S. H. Mohd Imam
2014-12-01
This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.
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Indian Academy of Sciences (India)
CPMGIKAlBGE-340/2003-05. Resonance - January 2005. Licenced to post WPP No.6 RT Nagar Postoffice. Florence Jessie Mac Williams. (1917 - 1990). Registered with Registrar of Newspapers in India vide Regn. No. 66273/96. ISSN 0971-8044. Price per copy: Rs 40.
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On the Shoulders of Sir Isaac Newton and Arthur Storer
Martin, Helen E.; Evans-Gondo, Bonita
2013-01-01
Helen E. Martin, the author of this article, is a retired National Board Certified Teacher who has been researching Sir Isaac Newton's unpublished manuscripts for over three decades. While researching the work of Newton, a teacher she was mentoring asked for some hands-on activities to study planetary motion. The description of the activity…
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Mailability v. the Crusader: Williams v. O'Brien.
Simmons, Charles E.
The issues of prior restraint and press censorship are examined in this paper, which focuses on the 1970 Williams v. O'Brien court case. The paper discusses the litigation, in which Robert F. Williams, as an American citizen living in Peking, China, sued the United States Postmaster General over the banning of the May 1967 issue of "The…
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[Sir Harold Ridley--the creator of modern cataract surgery].
Obuchowska, Iwona; Mariak, Zofia
2005-01-01
In February 2000, the worldwide ophthalmology community celebrated the 50th anniversary of one of the twentieth century's most important innovations in eye care--the implantation of the first intraocular lens after cataract extraction by Sir Harold Ridley. It was the initiation of a golden age for the development of ophthalmology, especially cataract surgery. In our paper we would like to remember this outstanding English ophthalmologist and his great invention.
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Operation STRANGLE (Italy, Spring 1944): A Case Study of Tactical Air Interdiction
1972-02-01
units. General Eaker reported to the new theater coi11Tlander, General Sir Henry Maitland ("Jumbo") Wilson, who had replaced General Eisenhower as...in Italy. The idea of using airpower on a massive scale to smash the German resistance on the I tal ian front was not new. It had been urged by...Brigadier W.G.F. Jackson, then on General Alexander’s staff, re- counts: "Moreover, he [General Alexander] was just as keen as Maitland Wilson [SACMED] to
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Sir Peter Medawar: science, creativity and the popularization of Karl Popper
Calver, Neil
2013-01-01
Sir Peter Medawar was respected by scientists and literati alike. It was perhaps not surprising, then, that he would choose to involve himself in the ‘two cultures’ debate of 1959 and beyond. The focus of his intervention was the philosophy of Sir Karl Popper. However, Medawar's Popper was not the guru of falsification familiar from philosophy textbooks. Medawar's distinctive interpretation of Popper treated him instead as the source of insights into the role of creativity and imagination in scientific inquiry. This paper traces the context for Medawar's adoption of Popperian philosophy, together with its application before the debate. It then examines, within the context of the debate itself, the way in which Medawar attempted to reconcile scientific inquiry with literary practice. Medawar became increasingly convinced that not only was induction epistemologically unsound, but it was also damaging to the public role of the scientist. His construction of Popperianism would, he envisaged, provide a worthy alternative for scientists’ self-image.
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Sir James Paget: Paget's disease of the nipple, Paget's disease of bone.
Ellis, Harold
2013-04-01
Sir James Paget was one of the 'great' Victorians. Eminent as a surgeon, pathologist and teacher, his nobility of character and application to his work made him a leader in his profession in that age of great men.
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2006-01-01
Lidy Williams-Oonk and her children Mark & Marietta, being unable to thank everybody individually, would like to express their sincere thanks to friends and colleagues at CERN and abroad for their great help and support, their messages and flowers, as well as their donations to the Ligue Genevoise contre le Cancer, on the death of their beloved husband and father.
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77 FR 19301 - Prince William Sound Regional Citizens' Advisory Council Charter Renewal
2012-03-30
... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2012-0099] Prince William Sound Regional... Prince William Sound Regional Citizens' Advisory Council (PWSRCAC) as an alternative voluntary advisory group for Prince William Sound, Alaska. This certification allows the PWSRCAC to monitor the activities...
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Interaction with William Carnall
International Nuclear Information System (INIS)
Judd, Brian R.
2005-01-01
A personal account is given of interaction with William T. Carnall during the period 1977-1988, when I made regular visits to the Argonne National Laboratory to discuss the theoretical background to the spectroscopic work he was carrying out on the lanthanides and actinides
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Global and local music perception in children with Williams syndrome.
Deruelle, Christine; Schön, Daniele; Rondan, Cécilie; Mancini, Josette
2005-04-25
Musical processing can be decomposed into the appreciation of global and local elements. This global/local dissociation was investigated with the processing of contour-violated and interval-violated melodies. Performance of a group of 16 children with Williams syndrome and a group of 16 control children were compared in a same-different task. Control participants were more accurate in detecting differences in the contour-violated than in the interval-violated condition while Williams syndrome individuals performed equally well in both conditions. This finding suggests that global precedence may occur at an early perceptual stage in normally developing children. In contrast, no such global precedence is observed in the Williams syndrome population. These data are discussed in the context of atypical cognitive profiles of individuals with Williams syndrome.
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A Possible Source For Sir Thomas More’s ‘Mountainish Inhumanity’
Steenbergh, Kristine
2017-01-01
Shakespeare’s authorship of a scene in Sir Thomas More has been established as highly probable on the basis of an analysis of the handwriting, vocabulary, and collocations stylistics. His addition to the play was long believed to have been written soon after publication of the original play, in
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Sir Victor Horsley (1857-1916): pioneer of neurological surgery.
Tan, Tze-Ching; Black, Peter McL
2002-03-01
Immortalized in surgical history for the introduction of "antiseptic wax," Sir Victor Horsley played a pivotal role in shaping the face of standard neurosurgical practice. His contributions include the first laminectomy for spinal neoplasm, the first carotid ligation for cerebral aneurysm, the curved skin flap, the transcranial approach to the pituitary gland, intradural division of the trigeminal nerve root for trigeminal neuralgia, and surface marking of the cerebral cortex. A tireless scientist, he was a significant player in discovering the cure for myxedema, the eradication of rabies from England, and the invention of the Horsley-Clarke stereotactic frame. As a pathologist, Horsley performed research on bacteria and edema and founded the Journal of Pathology. Horsley's kindness, humility, and generous spirit endeared him to patients, colleagues, and students. Born to privilege, he was nonetheless dedicated to improving the lot of the common man and directed his efforts toward the suffrage of women, medical reform, and free health care for the working class. Knighted in 1902 for his many contributions to medicine, Sir Victor met an untimely death during World War I from heat stroke at the age of 59. An iconoclast of keen intellect, unlimited energy, and consummate skill, his life and work justify his epitaph as a "pioneer of neurological surgery."
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Intracranial arteries in individuals with the elastin gene hemideletion of Williams syndrome.
Wint, D P; Butman, J A; Masdeu, J C; Meyer-Lindenberg, A; Mervis, C B; Sarpal, D; Morris, C A; Berman, K F
2014-01-01
Williams syndrome, a rare genetic disorder with a striking neurobehavioral profile characterized by extreme sociability and impaired visuospatial construction abilities, is caused by a hemideletion that includes the elastin gene, resulting in frequent supravavular aortic stenosis and other stenotic arterial lesions. Strokes have been reported in Williams syndrome. Although the extracranial carotid artery has been studied in a sample of patients with Williams syndrome, proximal intracranial arteries have not. Using MRA, we studied the intracranial vessels in 27 participants: 14 patients with Williams syndrome (age range, 18-44 years; mean age, 27.3 ± 9.1; 43% women) and 13 healthy control participants with similar age and sex distribution (age range, 22-52 years; mean age, 33.4 ± 7.6; 46% women). All participants with Williams syndrome had hemideletions of the elastin gene. Blinded to group allocation or to any other clinical data, a neuroradiologist determined the presence of intracranial vascular changes in the 2 groups. The Williams syndrome group and the healthy control group had similar patency of the proximal intracranial arteries, including the internal carotid and vertebral arteries; basilar artery; and stem and proximal branches of the anterior cerebral artery, MCA, and posterior cerebral arteries. The postcommunicating segment of the anterior cerebral artery was longer in the Williams syndrome group. Despite the elastin haploinsufficiency, the proximal intracranial arteries in Williams syndrome preserve normal patency.
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Sir John and Lady Rita Cornforth: a distinguished chemical partnership.
Purchase, Rupert; Hanson, James R
2015-01-01
This review describes the life of Sir John Cornforth AC CBE FRS, who was awarded the Nobel Prize for Chemistry in 1975. It covers his early life in Australia, his work in Oxford, the National Institute for Medical Research, the Milstead Laboratory of Chemical Enzymology and the University of Sussex, together with the contributions made by his wife, Lady Rita Cornforth.
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Stability and bifurcation analysis in a delayed SIR model
International Nuclear Information System (INIS)
Jiang Zhichao; Wei Junjie
2008-01-01
In this paper, a time-delayed SIR model with a nonlinear incidence rate is considered. The existence of Hopf bifurcations at the endemic equilibrium is established by analyzing the distribution of the characteristic values. A explicit algorithm for determining the direction of the Hopf bifurcation and the stability of the bifurcating periodic solutions are derived by using the normal form and the center manifold theory. Numerical simulations to support the analytical conclusions are carried out
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The use of multifrequency and polarimetric SIR-C/X-SAR data in geologic studies of Bir Safsaf, Egypt
Schaber, G.G.; McCauley, J.F.; Breed, C.S.
1997-01-01
Bir Safsaf, within the hyperarid 'core' of the Sahara in the Western Desert of Egypt, was recognized following the SIR-A and SIR-B missions in the 1980s as one of the key localities in northeast Africa, where penetration of dry sand by radar signals delineates previously unknown, sand-buried paleodrainage valleys ('radar-rivers') of middle Tertiary to Quaternary age. The Bir Safsaf area was targeted as a focal point for further research in sand penetration and geologic mapping using the multifrequency and polarimetric SIR-C/X-SAR sensors. Analysis of the SIR-C/X-SAR data from Bir Safsaf provides important new information on the roles of multiple SAR frequency and polarimetry in portraying specific types of geologic units, materials, and structures mostly hidden from view on the ground and on Landsat TM images by a relatively thin, but extensive blanket of blow sand. Basement rock units (granitoids and gneisses) and the fractures associated with them at Bir Safsaf are shown here for the first time to be clearly delineated using C- and L-band SAR images. The detectability of most geologic features is dependent primarily on radar frequency, as shown for wind erosion patterns in bedrock at X-band (3 cm wavelength), and for geologic units and sand and clay-filled fractures in weathered crystal-line basement rocks at C-band (6 cm) and L-band (24 cm). By contrast, Quaternary paleodrainage channels are detectable at all three radar frequencies owing, among other things, to an usually thin cover of blow sand. The SIR-C/X-SAR data investigated to date enable us to make specific recommendations about the utility of certain radar sensor configurations for geologic and paleoenvironmental reconnaissance in desert regions.Analysis of the shuttle imaging radar-C/X-synthetic aperture radar (SIR-C/X-SAR) data from Bir Safsaf provides important new information on the roles of multiple SAR frequency and polarimetry in portraying specific types of geologic units, materials, and
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[Association between Williams syndrome and adrenal insufficiency].
Rchachi, Meryem; Larwanou, Maazou Mahamane; El Ouahabi, Hanan; Ajdi, Farida
2017-01-01
Williams syndrome is a developmental disorder including dysmorphia, cardiovascular malformations and a specific neuropsychological profile together with other associated disorders. We report the case of a 17-year old girl, born of a non-inbred marriage, with Williams syndrome discovered during an assessment of degree of failure to thrive. Its association with primary adrenal insufficiency makes it unique. Diagnosis is confirmed by cytogenetic and molecular analysis. Its management consists of the implementation of treatment for adrenal insufficiency associated with a clinico-biological monitoring.
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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
DEFF Research Database (Denmark)
Lombard, David B; Alt, Frederick W; Cheng, Hwei-Ling
2007-01-01
Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here, we investigate the localization and function of SIRT3 in vivo. We show that endogenous mouse SIRT3 is a solubl...
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White matter integrity deficits in prefrontal-amygdala pathways in Williams syndrome.
Avery, Suzanne N; Thornton-Wells, Tricia A; Anderson, Adam W; Blackford, Jennifer Urbano
2012-01-16
Williams syndrome is a neurodevelopmental disorder associated with significant non-social fears. Consistent with this elevated non-social fear, individuals with Williams syndrome have an abnormally elevated amygdala response when viewing threatening non-social stimuli. In typically-developing individuals, amygdala activity is inhibited through dense, reciprocal white matter connections with the prefrontal cortex. Neuroimaging studies suggest a functional uncoupling of normal prefrontal-amygdala inhibition in individuals with Williams syndrome, which might underlie both the extreme amygdala activity and non-social fears. This functional uncoupling might be caused by structural deficits in underlying white matter pathways; however, prefrontal-amygdala white matter deficits have yet to be explored in Williams syndrome. We used diffusion tensor imaging to investigate prefrontal-amygdala white matter integrity differences in individuals with Williams syndrome and typically-developing controls with high levels of non-social fear. White matter pathways between the amygdala and several prefrontal regions were isolated using probabilistic tractography. Within each pathway, we tested for between-group differences in three measures of white matter integrity: fractional anisotropy (FA), radial diffusivity (RD), and parallel diffusivity (λ(1)). Individuals with Williams syndrome had lower FA, compared to controls, in several of the prefrontal-amygdala pathways investigated, indicating a reduction in white matter integrity. Lower FA in Williams syndrome was explained by significantly higher RD, with no differences in λ(1), suggestive of lower fiber density or axon myelination in prefrontal-amygdala pathways. These results suggest that deficits in the structural integrity of prefrontal-amygdala white matter pathways might underlie the increased amygdala activity and extreme non-social fears observed in Williams syndrome. Copyright © 2011 Elsevier Inc. All rights reserved.
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2016-03-28
in the future. Currency Issues Given its dependence on international trade , fluctuations in currency valuations can have significant impacts on...D. Nikitin Specialist in Nonproliferation Ian E. Rinehart Analyst in Asian Affairs Brock R. Williams Analyst in International Trade and Finance...posed by North Korea. Third, the two countries’ economies are closely entwined and are joined by the Korea-U.S. Free Trade Agreement (KORUS FTA
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Sir Rudolf Peierls Selected private and scientific correspondence
Lee, Sabine
2007-01-01
This edition of the private and scientific correspondence of Sir Rudolf Peierls gives a unique insight into the life and work of one of the greatest theoretical physicists of the 20th century. Rudolf Peierls' scientific work contributed to the early developments in quantum mechanics, and he is well known and much appreciated for his contributions to various disciplines, including solid state physics, nuclear physics, and particle physics. As an enthusiastic and devoted teacher, he passed on his knowledge and understanding and inspired the work of collaborators and students alike. As an effecti
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A Dirty Hero’s Fight for Clean Energy: Satire, Allegory, and Risk Narrative in Ian McEwan’s Solar
Evi Zemanek
2012-01-01
A diferencia de la mayoría de los textos de ficción que narran crisis écologicas, la novela "Solar" (2010) de Ian McEwan, celebrada como "el libro sobre el cambio climático", no esboza un escenario apocalíptico que culmina en una catástrofe colectiva. En lugar de eso, se burla a nivel del discurso de la actual retórica del riesgo, al mismo tiempo que pone en escena la desastrosa gestión de riesgos de su protagonista utilizando el género de la sátira. Mientras que las descr...
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Application of Homotopy Perturbation and Variational Iteration Methods to SIR Epidemic Model
DEFF Research Database (Denmark)
Ghotbi, Abdoul R.; Barari, Amin; Omidvar, M.
2011-01-01
effective strategy against childhood diseases, the development of the framework that would predict the optimal vaccine coverage level needed to prevent the spread of diseases is crucial. The SIR model is a standard compartmental model that has been used to describe many epidemiological diseases...
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Discovering Structure in Auditory Input: Evidence from Williams Syndrome
Elsabbagh, Mayada; Cohen, Henri; Karmiloff-Smith, Annette
2010-01-01
We examined auditory perception in Williams syndrome by investigating strategies used in organizing sound patterns into coherent units. In Experiment 1, we investigated the streaming of sound sequences into perceptual units, on the basis of pitch cues, in a group of children and adults with Williams syndrome compared to typical controls. We showed…
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Dental management of patient with Williams Syndrome - A case report.
Wong, Daniel; Ramachandra, Srinivas Sulugodu; Singh, Ashish Kumar
2015-01-01
Williams syndrome is a multisystemic rare genetic disorder caused by deletion of 26-28 genes in the long arm of chromosome 7. It is characterized by developmental and physical abnormalities including congenital cardiovascular abnormalities, mental retardation, neurological features, growth deficiency, genitourinary manifestations, gastrointestinal problems, musculoskeletal problems, unique behavioral characteristics, and dental problems. Dental abnormalities include malocclusion, hypodontia, malformed teeth, taurodontism, pulp stones, increased space between teeth, enamel hypoplasia, and high prevalence of dental caries. Authors report a 17-year-old female patient with underlying Williams syndrome. Oral features and problems seen in the patient are listed. Malocclusion and screwdriver shaped teeth were noticed. Generalized widening of the periodontal ligament space with vital teeth was seen. This finding has not been reported in cases of Williams syndrome earlier. Precautions taken during dental treatment in patients with Williams syndrome are also discussed.
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Sir Victor Horsley: pioneer craniopharyngioma surgeon.
Pascual, José M; Prieto, Ruth; Mazzarello, Paolo
2015-07-01
Sir Victor Horsley (1857-1916) is considered to be the pioneer of pituitary surgery. He is known to have performed the first surgical operation on the pituitary gland in 1889, and in 1906 he stated that he had operated on 10 patients with pituitary tumors. He did not publish the details of these procedures nor did he provide evidence of the pathology of the pituitary lesions operated on. Four of the patients underwent surgery at the National Hospital for Neurology and Neurosurgery (Queen Square, London), and the records of those cases were recently retrieved and analyzed by members of the hospital staff. The remaining cases corresponded to private operations whose records were presumably kept in Horsley's personal notebooks, most of which have been lost. In this paper, the authors have investigated the only scientific monograph providing a complete account of the pituitary surgeries that Horsley performed in his private practice, La Patologia Chirurgica dell'Ipofisi (Surgical Pathology of the Hypophysis), written in 1911 by Giovanni Verga, Italian assistant professor of anatomy at the University of Pavia. They have traced the life and work of this little-known physician who contributed to the preservation of Horsley's legacy in pituitary surgery. Within Verga's pituitary treatise, a full transcription of Horsley's notes is provided for 10 pituitary cases, including the patients' clinical symptoms, surgical techniques employed, intraoperative findings, and the outcome of surgery. The descriptions of the topographical and macroscopic features of two of the lesions correspond unmistakably to the features of craniopharyngiomas, one of the squamous-papillary type and one of the adamantinomatous type. The former lesion was found on necropsy after the patient's sudden death following a temporal osteoplastic craniectomy. Surgical removal of the lesion in the latter case, with the assumed nature of an adamantinomatous craniopharyngioma, was successful. According to the
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Sir William Henry Perkin: The Man and his 'Mauve'
Indian Academy of Sciences (India)
design was different. Just before he .... leaving the Royal College of Chemistry to take up manufacturing, as it was ... For Perkin, the situation to start an industry to manufacture .... Alizarin, in the early years of its production, had become a.
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75 FR 16159 - Prince William Sound Regional Citizens' Advisory Council (PWSRCAC) Charter Renewal
2010-03-31
... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2010-0121] Prince William Sound Regional... the Prince William Sound Regional Citizens' Advisory Council (PWSRCAC) as an alternative voluntary advisory group for Prince William Sound, Alaska. This certification allows the PWSRCAC to monitor the...
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Directory of Open Access Journals (Sweden)
Tânia Reis
2010-11-01
Full Text Available Obesity has a strong genetic component, but few of the genes that predispose to obesity are known. Genetic screens in invertebrates have the potential to identify genes and pathways that regulate the levels of stored fat, many of which are likely to be conserved in humans. To facilitate such screens, we have developed a simple buoyancy-based screening method for identifying mutant Drosophila larvae with increased levels of stored fat. Using this approach, we have identified 66 genes that when mutated increase organismal fat levels. Among these was a sirtuin family member, Sir2. Sirtuins regulate the storage and metabolism of carbohydrates and lipids by deacetylating key regulatory proteins. However, since mammalian sirtuins function in many tissues in different ways, it has been difficult to define their role in energy homeostasis accurately under normal feeding conditions. We show that knockdown of Sir2 in the larval fat body results in increased fat levels. Moreover, using genetic mosaics, we demonstrate that Sir2 restricts fat accumulation in individual cells of the fat body in a cell-autonomous manner. Consistent with this function, changes in the expression of metabolic enzymes in Sir2 mutants point to a shift away from catabolism. Surprisingly, although Sir2 is typically upregulated under conditions of starvation, Sir2 mutant larvae survive better than wild type under conditions of amino-acid starvation as long as sugars are provided. Our findings point to a Sir2-mediated pathway that activates a catabolic response to amino-acid starvation irrespective of the sugar content of the diet.
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Anderson, Prof. Basil Williams
Indian Academy of Sciences (India)
Home; Fellowship. Fellow Profile. Elected: 1964 Honorary. Anderson, Prof. Basil Williams. Date of birth: 3 July 1901. Date of death: 24 February 1984. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...
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Indian Academy of Sciences (India)
Home; Fellowship. Fellow Profile. Elected: 1984 Honorary. Series, Prof. George William. Date of birth: 22 February 1920. Date of death: 2 January 1995. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...
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Segre, Elisabetta; Pigozzi, Luca; Lison, Davide; Pivetta, Emanuele; Bosco, Ornella; Vizio, Barbara; Suppo, Umberto; Turvani, Fabrizio; Morello, Fulvio; Battista, Stefania; Moiraghi, Corrado; Montrucchio, Giuseppe; Lupia, Enrico
2014-10-01
Thrombopoietin (TPO), a growth factor primarily involved in regulating thrombopoiesis, has been recently implicated in the pathogenesis of sepsis. TPO levels are, indeed, greatly increased in patients with sepsis compared to control subjects, and correlate with sepsis severity. The aim of this study was to evaluate TPO as predictive biomarker of sepsis and of sepsis severity in patients entering the emergency department (ED) with systemic inflammatory response syndrome (SIRS). This was a prospective observational study. Ours is a sub-study of the 'Need-speed trial', a multi-center observational study involving six Italian centers affiliated to the GREAT Italian Network. TPO was measured by ELISA. We enrolled 13 patients with SIRS (6 with acute pancreatitis, 3 with acute heart failure, 1 with pulmonary embolism, and 3 with allergic reactions), and 40 patients with sepsis, eight of whom had severe sepsis and three septic shock. TPO was significantly higher in patients with sepsis than with SIRS. In addition, TPO was higher in patients with severe sepsis than with sepsis, and in patients with septic shock than with severe sepsis, although these differences did not reach the statistical significance. Our preliminary results suggest that TPO may have the potential to be considered a promising early biomarker for both the diagnosis of sepsis and the assessment of sepsis severity in patients with SIRS entering the ED.
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The use of emotions in narratives in Williams syndrome.
Van Herwegen, Jo; Aznar, Ana; Tenenbaum, Harriet
2014-01-01
Although individuals with Williams syndrome are very sociable, they tend to have limited contact and friendships with peers. In typically developing children the use of positive emotions (e.g., happy) has been argued to be related to peer relationships and popularity. The current study investigated the use and development of emotion words in Williams syndrome using cross-sectional developmental trajectories and examined children's use of different types of emotion words. Nineteen children with Williams syndrome (WS) and 20 typically developing (TD) children matched for chronological age told a story from a wordless picture book. Participants with WS produced a similar number of emotion words compared to the control group and the use of emotion words did not change when plotted against chronological age or vocabulary abilities in either group. However, participants with WS produced more emotion words about sadness. Links between emotion production and friendships as well as future studies are discussed. After reading this article, readers will be able to: explain the development of positive and negative emotions in Williams syndrome and recognize that emotion production is atypical in this population. Copyright © 2014 Elsevier Inc. All rights reserved.
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33 CFR 167.1701 - In Prince William Sound: Precautionary areas.
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false In Prince William Sound: Precautionary areas. 167.1701 Section 167.1701 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1701 In Prince William Sound...
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A MacWilliams Identity for Convolutional Codes : The General Case
Gluesing-Luerssen, Heide; Schneider, Gert
A MacWilliams Identity for convolutional codes will be established. It makes use of the weight adjacency matrices of the code and its dual, based on state space realizations (the controller canonical form) of the codes in question. The MacWilliams Identity applies to various notions of duality
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En torno a la construcción social de la locura: Ian Hacking y la historia cultural de la psiquiatría
Huertas, Rafael
2011-01-01
El objetivo de este trabajo es analizar la contribución del filósofo de la ciencia Ian Hacking a la historia cultural de la psiquiatría. Partiendo de conceptos propuestos por el autor, como "enfermedad mental transitoria" o "inventar/construir gente", se reflexiona en torno a la construcción socio-cultural de la enfermedad mental. Se examinan y discuten los dos estudios de caso propuestos por Hacking: la fuga disociativa y la personalidad múltiple, identificando las fortalezas y debilidades d...
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Probed Serial Recall in Williams Syndrome: Lexical Influences on Phonological Short-Term Memory
Brock, Jan; McCormack, Teresa; Boucher, Jill
2005-01-01
Williams syndrome is a genetic disorder that, it has been claimed, results in an unusual pattern of linguistic strengths and weaknesses. The current study investigated the hypothesis that there is a reduced influence of lexical knowledge on phonological short-term memory in Williams syndrome. Fourteen children with Williams syndrome and 2…
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Directory of Open Access Journals (Sweden)
Jeanette Orbegozo
2014-03-01
Full Text Available The Oomycete Phytophthora infestans (Mont. de Bary, the causal agent of the disease known as late blight, is primarily responsible for the decreased in production performance and potato crops worldwide. The integration of the complete Rgenes sequences in the potato genome using Agro-transformation appears an alternative to be considered in the fight against this pathogen. The Rpi-blb2 gene (Rgene from the wild species Solanum bulbocastanumDunal shows a broad resistance to isolates ofP. infestans,making it an important candidate for plant breeding studies. This paper reports the integration of the Rpi-blb2gene into potato var. Désirée genome by Agrobacterium tumefaciens- mediated transformation system, the molecular characterization of 29 events transformed and whole plant infection with isolate POX67 of P. infestansfrom Peru. Désirée events [Rpi-blb2] 4 and Désirée [Rpi-blb2] 30, showed a substantial resistance to P. infestansinfection confirming complete transfer of the Rpi-blb2gene from a wild species to a cultivated species by genetic transformation.
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78 FR 28953 - William D. Ford Federal Direct Loan Program
2013-05-16
.... Ford Federal Direct Loan Program; Interim Final Rule #0;#0;Federal Register / Vol. 78, No. 95... [Docket ID ED-2013-OPE-0066] RIN 1840-AD13 William D. Ford Federal Direct Loan Program AGENCY: Office of... Secretary amends the William D. Ford Federal Direct Loan Program (Direct Loan Program) regulations to...
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Pursuing the Panderer: An Analysis of "United States v. Williams"
McGrain, Patrick N.; Moore, Jennifer L.
2010-01-01
In May 2008, the Supreme Court addressed whether the government can regulate the ownership and distribution of virtual child pornography. "U.S. v. Williams" marked the first time the Court directly addressed the concept of pandering virtual child pornography. This article examines the Court's decision in "U.S. v. Williams" and…
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Prince William Sound, Alaska ESI: INDEX
National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) data for Prince William Sound, Alaska. ESI data characterize estuarine environments and wildlife by...
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Using novel control groups to dissect the amygdala's role in Williams syndrome.
Thornton-Wells, Tricia A; Avery, Suzanne N; Blackford, Jennifer Urbano
2011-07-01
Williams syndrome is a neurodevelopmental disorder with an intriguing behavioral phenotype-hypersociability combined with significant non-social fears. Previous studies have demonstrated abnormalities in amygdala function in individuals with Williams syndrome compared to typically-developing controls. However, it remains unclear whether the findings are related to the atypical neurodevelopment of Williams syndrome, or are also associated with behavioral traits at the extreme end of a normal continuum. We used functional magnetic resonance imaging (fMRI) to compare amygdala blood-oxygenation-level-dependent (BOLD) responses to non-social and social images in individuals with Williams syndrome compared to either individuals with inhibited temperament (high non-social fear) or individuals with uninhibited temperament (high sociability). Individuals with Williams syndrome had larger amygdala BOLD responses when viewing the non-social fear images than the inhibited temperament control group. In contrast, when viewing both fear and neutral social images, individuals with Williams syndrome did not show smaller amygdala BOLD responses relative to the uninhibited temperament control group, but instead had amygdala responses proportionate to their sociability. These results suggest heightened amygdala response to non-social fear images is characteristic of WS, whereas, variability in amygdala response to social fear images is proportionate to, and might be explained by, levels of trait sociability.
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2011-01-07
... Prince William Sound Regional Citizens' Advisory Council AGENCY: Coast Guard, DHS. ACTION: Notice of... on, the application for recertification submitted by the Prince William Sound Regional Citizen's... advisory group in lieu of a Regional Citizens' Advisory Council for Prince William Sound, Alaska. This...
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Directory of Open Access Journals (Sweden)
Caterina Novák
2013-12-01
Full Text Available The aim of this article is to explore the parallels between two late-nineteenth-century utopias,William Henry Hudsons A Crystal Age (1882 and William Morriss News from Nowhere (1891. Itaims to explore how these two works respond to the transition from a kinetic to a static conception ofutopia that under pressure from evolutionary and feminist discourses took place during the period.Particular focus lies on the way in which this is negotiated through the depiction of evolution, sexuality,and gender roles in the respective novels, and how the depiction of these disruptive elements may workas a means of ensuring the readers active engagement in political, intellectual and emotional terms.
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The optimal dynamic immunization under a controlled heterogeneous node-based SIRS model
Yang, Lu-Xing; Draief, Moez; Yang, Xiaofan
2016-05-01
Dynamic immunizations, under which the state of the propagation network of electronic viruses can be changed by adjusting the control measures, are regarded as an alternative to static immunizations. This paper addresses the optimal dynamical immunization under the widely accepted SIRS assumption. First, based on a controlled heterogeneous node-based SIRS model, an optimal control problem capturing the optimal dynamical immunization is formulated. Second, the existence of an optimal dynamical immunization scheme is shown, and the corresponding optimality system is derived. Next, some numerical examples are given to show that an optimal immunization strategy can be worked out by numerically solving the optimality system, from which it is found that the network topology has a complex impact on the optimal immunization strategy. Finally, the difference between a payoff and the minimum payoff is estimated in terms of the deviation of the corresponding immunization strategy from the optimal immunization strategy. The proposed optimal immunization scheme is justified, because it can achieve a low level of infections at a low cost.
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An SIRS model with a nonlinear incidence rate
International Nuclear Information System (INIS)
Jin Yu; Wang, Wendi; Xiao Shiwu
2007-01-01
The global dynamics of an SIRS model with a nonlinear incidence rate is investigated. We establish a threshold for a disease to be extinct or endemic, analyze the existence and asymptotic stability of equilibria, and verify the existence of bistable states, i.e., a stable disease free equilibrium and a stable endemic equilibrium or a stable limit cycle. In particular, we find that the model admits stability switches as a parameter changes. We also investigate the backward bifurcation, the Hopf bifurcation and Bogdanov-Takens bifurcation and obtain the Hopf bifurcation criteria and Bogdanov-Takens bifurcation curves, which are important for making strategies for controlling a disease
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A case of William's syndrome associated peripheral pulmonary arterial stenosis
International Nuclear Information System (INIS)
Jung, Kyung Hwa; Hwang, Mi Soo; Kim, Sun Yong; Chang, Jae Chun; Park, Bok Hwan
1988-01-01
William's syndrome, in order to more completely delineate the total spectrum of the disorder, indicates that 'infantile hypercalcemia', 'peculiar facies' and 'supravalvular aortic stenosis.' In has other many vascular anomalies, such as peripheral pulmonary arterial stenosis, coronary arterial stenosis, celiac arterial stenosis, and renal aterial stenosis. Only 32% of the patients have evidence of supravalvular aortic stenosis. And it is very rare disease entity that has been reported rarely in Korea. Recently authors experienced a case that was questioned William's syndrome with peripheral pulmonary arterial stenosis, clinically and preliminary radiologically and this case was confirmed by operation. Here we report a case of William's syndrome with peripheral pulmonary arterial stenosis and reviewed literatures
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Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.
Ondracek, Caitlin R; Frappier, Vincent; Ringel, Alison E; Wolberger, Cynthia; Guarente, Leonard
2017-03-07
Sirtuin enzymes depend on NAD + to catalyze protein deacetylation. Therefore, the lowering of NAD + during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic screen to identify two mutations in the catalytic domain of yeast Sir2 that allow the enzyme to function in an NAD + -depleted environment. These mutant enzymes give rise to a significant increase of yeast replicative lifespan and increase deacetylation by the Sir2 ortholog, SIRT1, in mammalian cells. Our data suggest that these mutations increase the stability of the conserved catalytic sirtuin domain, thereby increasing the catalytic efficiency of the mutant enzymes. Our approach to identifying sirtuin mutants that permit function in NAD + -limited environments may inform the design of small molecules that can maintain sirtuin activity in aging organisms. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
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Plasma: the genesis of the word
Pinheiro, Mario J.
2007-01-01
The historical roots of the word plasma are recalled. It is suggested that possibly at the beginning of the researches in low-pressure gas discharges the driving motivation was related to the psychic phenomena investigated by Sir William Crookes.
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Directory of Open Access Journals (Sweden)
Mukhanif Yasin Yusuf
2015-06-01
Dengan menggunakan pendekatan teori sosiologi sastra Ian Watt, Biola Tak Berdawai tidak jauh berbeda dengan karya-karya Seno lainnya yang melemparkan gagasan kritis terhadap realitas sosial. Latar belakang sosial Seno yang sekaligus sebagai wartawan melemparkan gagasan kritisnya terkait kondisi difabel yang masih mendapat stigma negatif dari masyarakat. Cerminan sosial dalam novel tidak jauh berbeda dengan realitas yang terjadi di Indonesia, dimana ideologi kenormalan menyumbangkan berbagai bentuk ketidakadilan terhadap difabel. Difabel masih dianggap sebagai individu yang cacat, sebagai kutukan Tuhan, dan sebagai sumber aib bagi keluarga. Pendobrakan terhadap realitas yang ada, dilakukan pengarang lewat tokoh utama “Aku” yang difabel dengan menyajikan fakta bahwa difabel memiliki kemampuan yang berbeda, tetapi masyarakat masih belum memahaminya karena sudah terlanjur terjebak pada stigma negatif terhadap difabel.
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A MacWilliams Identity for Convolutional Codes: The General Case
Gluesing-Luerssen, Heide; Schneider, Gert
2008-01-01
A MacWilliams Identity for convolutional codes will be established. It makes use of the weight adjacency matrices of the code and its dual, based on state space realizations (the controller canonical form) of the codes in question. The MacWilliams Identity applies to various notions of duality appearing in the literature on convolutional coding theory.
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Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination
Miao, Anqi; Zhang, Jian; Zhang, Tongqian; Pradeep, B. G. Sampath Aruna
2017-01-01
A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control.
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Bora Bora, Tahaa, and Raiatea, French Polynesia, Landsat and SIR-C Images Compared to SRTM Shaded
2005-01-01
Bora Bora, Tahaa, and Raiatea (top to bottom) are Polynesian Islands about 220 kilometers (135 miles) west-northwest of Tahiti in the South Pacific. Each of the islands is surrounded by a coral reef and its associated islets ('motus') that enclose a lagoon. Actually, as seen here, Tahaa and Raiatea are close enough together to share a common lagoon and reef. These islands are volcanic in origin and were built up from the sea floor by lava extrusions millions of years ago. None is now active, and all are deeply eroded. This display compares three differing 'views from space' of these islands. On the left, an image from the Landsat 7 satellite shows the islands as they might have appeared to an astronaut in orbit in 1999 (but a little sharper and with atmospheric haze suppressed). In the middle is an image created from data gathered by the third-generation Shuttle Imaging Radar (SIR-C), flown in 1994. On the right is a graphic illustrating elevation data gathered by the Shuttle Radar Topography Mission (SRTM) in 2000. Each of these images shows very different information as compared to the other two. Landsat sees clouds, which are almost always above these islands, blocking the view of the terrain. It also readily sees through shallow water down to the reefs. SIR-C sees the waves and other effects of winds upon the ocean surface. It does not look through water to see the reefs, but it clearly separates land and water. It also provides a bolder (but distorted) view of the islands' topographic patterns. With the ability of radar to see through clouds and provision of its own illumination, the SIR-C view is not limited by clouds nor their shadows. SRTM was designed to provide new information that is missing in the Landsat and SIR-C views. Specifically, SRTM created the world's first near-global, detailed elevation model. Natural topographic shading in Landsat imagery and radar topographic shadowing of SIR-C give some evidence of the shape of the ground but do not
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Psychotherapy In General Practice
African Journals Online (AJOL)
1974-08-03
Aug 3, 1974 ... According to Sir William OsIer, 'The contractor put in poor materials'. ... affairs, stressful situations at work, tension, lack of scope . for self-realisation or ... endure an emotional impact of a very high intensity, which may even ...
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Learning by observation: insights from Williams syndrome.
Foti, Francesca; Menghini, Deny; Mandolesi, Laura; Federico, Francesca; Vicari, Stefano; Petrosini, Laura
2013-01-01
Observing another person performing a complex action accelerates the observer's acquisition of the same action and limits the time-consuming process of learning by trial and error. Observational learning makes an interesting and potentially important topic in the developmental domain, especially when disorders are considered. The implications of studies aimed at clarifying whether and how this form of learning is spared by pathology are manifold. We focused on a specific population with learning and intellectual disabilities, the individuals with Williams syndrome. The performance of twenty-eight individuals with Williams syndrome was compared with that of mental age- and gender-matched thirty-two typically developing children on tasks of learning of a visuo-motor sequence by observation or by trial and error. Regardless of the learning modality, acquiring the correct sequence involved three main phases: a detection phase, in which participants discovered the correct sequence and learned how to perform the task; an exercise phase, in which they reproduced the sequence until performance was error-free; an automatization phase, in which by repeating the error-free sequence they became accurate and speedy. Participants with Williams syndrome beneficiated of observational training (in which they observed an actor detecting the visuo-motor sequence) in the detection phase, while they performed worse than typically developing children in the exercise and automatization phases. Thus, by exploiting competencies learned by observation, individuals with Williams syndrome detected the visuo-motor sequence, putting into action the appropriate procedural strategies. Conversely, their impaired performances in the exercise phases appeared linked to impaired spatial working memory, while their deficits in automatization phases to deficits in processes increasing efficiency and speed of the response. Overall, observational experience was advantageous for acquiring competencies
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Learning by observation: insights from Williams syndrome.
Directory of Open Access Journals (Sweden)
Francesca Foti
Full Text Available Observing another person performing a complex action accelerates the observer's acquisition of the same action and limits the time-consuming process of learning by trial and error. Observational learning makes an interesting and potentially important topic in the developmental domain, especially when disorders are considered. The implications of studies aimed at clarifying whether and how this form of learning is spared by pathology are manifold. We focused on a specific population with learning and intellectual disabilities, the individuals with Williams syndrome. The performance of twenty-eight individuals with Williams syndrome was compared with that of mental age- and gender-matched thirty-two typically developing children on tasks of learning of a visuo-motor sequence by observation or by trial and error. Regardless of the learning modality, acquiring the correct sequence involved three main phases: a detection phase, in which participants discovered the correct sequence and learned how to perform the task; an exercise phase, in which they reproduced the sequence until performance was error-free; an automatization phase, in which by repeating the error-free sequence they became accurate and speedy. Participants with Williams syndrome beneficiated of observational training (in which they observed an actor detecting the visuo-motor sequence in the detection phase, while they performed worse than typically developing children in the exercise and automatization phases. Thus, by exploiting competencies learned by observation, individuals with Williams syndrome detected the visuo-motor sequence, putting into action the appropriate procedural strategies. Conversely, their impaired performances in the exercise phases appeared linked to impaired spatial working memory, while their deficits in automatization phases to deficits in processes increasing efficiency and speed of the response. Overall, observational experience was advantageous for
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Patterns of Gram-stained fecal flora as a quick diagnostic marker in patients with severe SIRS.
Shimizu, Kentaro; Ogura, Hiroshi; Tomono, Kazunori; Tasaki, Osamu; Asahara, Takashi; Nomoto, Koji; Morotomi, Masami; Matsushima, Asako; Nakahori, Yasutaka; Yamano, Shuhei; Osuka, Akinori; Kuwagata, Yasuyuki; Sugimoto, Hisashi
2011-06-01
The gut is an important target organ of injury during critically ill conditions. Although Gram staining is a common and quick method for identifying bacteria, its clinical application has not been fully evaluated in critically ill conditions. This study's aims were to identify patterns of Gram-stained fecal flora and compare them to cultured bacterial counts and to investigate the association between the patterns and septic complications in patients with severe systemic inflammatory response syndrome (SIRS). Fifty-two patients with SIRS were included whose Gram-stained fecal flora was classified into three patterns. In a diverse pattern, large numbers of multiple kinds of bacteria completely covered the field. In a single pattern, one specific kind of bacteria or fungi predominantly covered the field. In a depleted pattern, most bacteria were diminished in the field. In the analysis of fecal flora, the numbers of total obligate anaerobes in the depleted pattern was significantly lower than those in the diverse pattern and single pattern (p Gram-stained fecal flora can be classified into three patterns and are associated with both cultured bacterial counts and clinical information. Gram-stained fecal bacteria can be used as a quick bedside diagnostic marker for severe SIRS patients.
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Directory of Open Access Journals (Sweden)
Irene R. Fairley
1981-09-01
Full Text Available Williams' admiration for Brueghel's landscape is coded in structural and stylistic correspondences between the poem and the painting. Structures in the poem have effects analogous to the use of devices of color, line, foregrounding in the painting. The poem, like the painting, presents a «neutral» scene but subtly insures the reader's involvement. Further, Williams draws a visual statement so that graphic features suggest a global image isomorphic with the motif of descent. Features of the poem, such as line and clause length, syntactic construction, semantic coherence, are discussed as factors that contribute to rapid glancing and increase readability. A study of readers shows their sensitivity to graphic features including the poem's shape, and corroborates the importance of stylistic features.
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Désir, besoin, dépendance : l'addiction comme (épreuve de la modernité
Directory of Open Access Journals (Sweden)
Rita Di Lorenzo
2016-04-01
Full Text Available La frontière entre la santé et la pathologie est un lieu fascinant et dangereux, au caractère poreux et riche de familiarités des deux côtés, inavouées et coûteuses. Le terme d’addiction semble s’installer précisément sur cette frontière, gagnant en étendue médiatique ce qu’il perd en précision nosographique ; ainsi, aujourd’hui, nous serions « tous addicts » – au sucre, au téléphone portable, au chocolat, au café, aux soldes, à la chirurgie esthétique, à Facebook, à l’amour, cette liste pouvant être continuée par chacun d’entre nous puisque nous avons tous fait, nous faisons et ferons tous, l’expérience de la force des (mauvaises habitudes, du désir, voire de la pulsion, de l’abus et de la dépendance. Notre société contemporaine semble stimuler cette expérience, en multipliant tant les objets addictogènes que les comportements addictifs : d’une part par le statut attribué aux biens sériels, d’autre part par la dimension pulsionnelle revendiquée dans les habitudes de consommation. Société du plaisir, peut-être plus hédoniste qu’épicurienne, l’époque contemporaine impose le plaisir et son désir comme nouvelle norme. Dès lors, quel est notre rapport à la pulsion, au désir compulsif, au dépassement des limites imposées aux besoins et aux envies socialement acceptables ? Comment notre société régule le désir ? Comment la politique et les médias concourent-ils à le structurer, voire à le prescrire ? Quels mécanismes à l’œuvre dans l’addiction contredisent cette prescription, et surtout : s’agit-il véritablement d’une contradiction ? Notre culture de performance et satisfaction rapides peut effectivement expliquer certaines dépendances induites par leur objet ; néanmoins, la véritable addiction mentale se nourrit d’éléments plus profondément constitutifs de l’identité de l’homme moderne et contemporain : avant tout, la fragilité des acquis, la
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Vaccination strategies for SIR vector-transmitted diseases.
Cruz-Pacheco, Gustavo; Esteva, Lourdes; Vargas, Cristobal
2014-08-01
Vector-borne diseases are one of the major public health problems in the world with the fastest spreading rate. Control measures have been focused on vector control, with poor results in most cases. Vaccines should help to reduce the diseases incidence, but vaccination strategies should also be defined. In this work, we propose a vector-transmitted SIR disease model with age-structured population subject to a vaccination program. We find an expression for the age-dependent basic reproductive number R(0), and we show that the disease-free equilibrium is locally stable for R(0) ≤ 1, and a unique endemic equilibrium exists for R(0) > 1. We apply the theoretical results to public data to evaluate vaccination strategies, immunization levels, and optimal age of vaccination for dengue disease.
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Interview: William and Barbara Christopher.
Teaching Exceptional Children, 1986
1986-01-01
Asserting that the biggest mistake educators can make is to set themselves up as experts vis-a-vis parents as amateurs, Barbara and William Christopher emphasize the importance of continued education for the autistic individual and relate their experiences with the educational community as they sought help for their autistic son. (JC)
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Jiao, Jianjun; Cai, Shaohong; Li, Limei
2016-05-01
To understand the effect of impulsive vaccination and restricting infected individuals boarding transports on disease spread, we establish an SIR model with impulsive vaccination, impulsive dispersal and restricting infected individuals boarding transports. This SIR epidemic model for two regions, which are connected by transportation of non-infected individuals, portrays the evolvement of diseases. We prove that all solutions of the investigated system are uniformly ultimately bounded. We also prove that there exists globally asymptotically stable infection-free boundary periodic solution. The condition for permanence is discussed. It is concluded that the approach of impulsive vaccination and restricting infected individuals boarding transports provides reliable tactic basis for preventing disease spread.
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Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination
Directory of Open Access Journals (Sweden)
Anqi Miao
2017-01-01
Full Text Available A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control.
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Directory of Open Access Journals (Sweden)
Sutanto .
2013-07-01
SIR-B image proves to be a reasonably good tool to identify rural settlement in an open area, especially for that with high density of houses. Its use to identify towns and cities is more recommended.
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2013-02-20
...; Comment Request; William D. Ford Federal Direct Loan Program (DL) Regulations AGENCY: Department of... in response to this notice will be considered public records. Title of Collection: William D. Ford.... Abstract: The William D. Ford Federal Direct Loan Program regulations cover areas of program administration...
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Rorty, Williams, and Davidson: Skepticism and Metaepistemology
Directory of Open Access Journals (Sweden)
Christopher Ranalli
2013-07-01
Full Text Available We revisit an important exchange on the problem of radical skepticism between Richard Rorty and Michael Williams. In his contribution to this exchange, Rorty defended the kind of transcendental approach to radical skepticism that is offered by Donald Davidson, in contrast to Williams’s Wittgenstein-inspired view. It is argued that the key to evaluating this debate is to understand the particular conception of the radical skeptical problem that is offered in influential work by Barry Stroud, a conception of the skeptical problem which generates metaepistemological ramifications for anti-skeptical theories. In particular, we argue that, contra Williams, Rorty’s view that Davidson was offering a theoretical diagnosis of radical skepticism can be consistently maintained with his transcendental approach.
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SIR-A views our environment An Experiment in the Batu Angkal Area, West Kalimantan, Indonesia
Directory of Open Access Journals (Sweden)
Sutanto .
2013-07-01
Factors affecting the ease of identification are. mainly tonal contrast, shape, size, surface roughness, direction in relation to the illumination, and dielectric constant. Due to the future availability of SIR-B image of Kalimantan, further study is recommended.
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Music and Anxiety in Williams Syndrome: A Harmonious or Discordant Relationship?
Dykens, Elisabeth M.; Rosner, Beth A.; Ly, Tran; Sagun, Jaclyn
2005-01-01
In this two-part study, we assessed musical involvements in two samples of persons with Williams syndrome compared to others with mental retardation and also related musicality to anxiety and fears in Study 2. Relative to others with mental retardation, those with Williams syndrome were more likely to take music lessons, play an instrument, and…
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[Sir Francis Galton: the father of eugenics].
Aubert-Marson, Dominique
2009-01-01
Not only was Sir Francis Galton a famous geographer and statistician, he also invented "eugenics" in 1883. Eugenics, defined as the science of improving racial stock, was developed from a new heredity theory, conceived by Galton himself, and from the evolution theory of Charles Darwin, transposed to human society by Herbert Spencer. Galton's eugenics was a program to artificially produce a better human race through regulating marriage and thus procreation. Galton put particular emphasis on "positive eugenics", aimed at encouraging the physically and mentally superior members of the population to choose partners with similar traits. In 1904, he presented his ideas in front of a vast audience of physicians and scientists in London. His widely-publicized lecture served as the starting point for the development of eugenics groups in Europe and the United States during the first half of the 20th century.
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Influence of heat conductivity on the performance of RTV SIR coatings with different fillers
Energy Technology Data Exchange (ETDEWEB)
Siderakis, K [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, GR-26110 Patras (Greece); Agoris, D [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, Greece, GR-26500, Rion, Greece (Greece); Gubanski, S [High Voltage Laboratory, Department of Electric Power Engineering, Chalmers University of Technology, S-41296, Gothenburg (Sweden)
2005-10-07
Room temperature vulcanized silicone rubber (RTV SIR) coatings are employed in order to improve the pollution performance of high voltage ceramic insulators by imparting surface hydrophobicity. In this paper, the performance of three RTV SIR coatings containing different fillers is investigated in a salt-fog test. Alumina trihydrate (ATH) and silica are the fillers included in the formulation, aiming to increase the material endurance to the energy supplied by the surface electrical activity during periods of hydrophobicity loss. The primary action of these fillers is to increase the material heat conductivity, i.e. the amount of energy conducted to the substrate. In addition, in the case of ATH relief is also achieved due to particle decomposition. The results indicate that for the compositions commercially available, where low amounts of fillers are used, and under the conditions of the test, ATH filled coatings performed better than the silica filled ones. This is attributed to ATH decomposition which further relieves the material structure and therefore decelerates material aging.
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Prince William Sound, Alaska ESI: HYDRO (Hydrology)
National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) data for Prince William Sound, Alaska. ESI data characterize estuarine environments and wildlife by...
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Prince William Sound, Alaska ESI: INVERT (Invertebrates)
National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) data for Prince William Sound, Alaska. ESI data characterize estuarine environments and wildlife by...
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Who Was the Real William Shakespeare?
Edwards, Michael Todd
2009-01-01
This article highlights a project that encourages students to connect reading and mathematics instruction by using a data analysis approach. Students analyze sonnets from statistical, literary, and historical points of view in an effort to uncover the true identity of William Shakespeare. (Contains 10 figures.)
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Mr. William Shakespeare and the Internet.
Reeves, Barbara
2000-01-01
Describes resources and links on a Web site entitled "Mr. William Shakespeare and the Internet," with suggestions for using them with students. Highlights include: historical context; impact of events/situations on works; motivational/preparatory lessons; reading and understanding Shakespeare; analysis of works; language; assessing other…
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Orlandi, Ivan; Pellegrino Coppola, Damiano; Strippoli, Maurizio; Ronzulli, Rossella; Vai, Marina
2017-01-01
Nicotinamide (NAM), a form of vitamin B 3 , is a byproduct and noncompetitive inhibitor of the deacetylation reaction catalyzed by Sirtuins. These represent a family of evolutionarily conserved NAD + -dependent deacetylases that are well-known critical regulators of metabolism and aging and whose founding member is Sir2 of Saccharomyces cerevisiae. Here, we investigated the effects of NAM supplementation in the context of yeast chronological aging, the established model for studying aging of postmitotic quiescent mammalian cells. Our data show that NAM supplementation at the diauxic shift results in a phenocopy of chronologically aging sir2Δ cells. In fact, NAM-supplemented cells display the same chronological lifespan extension both in expired medium and extreme Calorie Restriction. Furthermore, NAM allows the cells to push their metabolism toward the same outcomes of sir2Δ cells by elevating the level of the acetylated Pck1. Both these cells have the same metabolic changes that concern not only anabolic pathways such as an increased gluconeogenesis but also respiratory activity in terms both of respiratory rate and state of respiration. In particular, they have a higher respiratory reserve capacity and a lower non-phosphorylating respiration that in concert with a low burden of superoxide anions can affect positively chronological aging. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
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MacWilliams Identity for M-Spotty Weight Enumerator
Suzuki, Kazuyoshi; Fujiwara, Eiji
M-spotty byte error control codes are very effective for correcting/detecting errors in semiconductor memory systems that employ recent high-density RAM chips with wide I/O data (e.g., 8, 16, or 32bits). In this case, the width of the I/O data is one byte. A spotty byte error is defined as random t-bit errors within a byte of length b bits, where 1 le t ≤ b. Then, an error is called an m-spotty byte error if at least one spotty byte error is present in a byte. M-spotty byte error control codes are characterized by the m-spotty distance, which includes the Hamming distance as a special case for t =1 or t = b. The MacWilliams identity provides the relationship between the weight distribution of a code and that of its dual code. The present paper presents the MacWilliams identity for the m-spotty weight enumerator of m-spotty byte error control codes. In addition, the present paper clarifies that the indicated identity includes the MacWilliams identity for the Hamming weight enumerator as a special case.
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Global analysis of multi-strains SIS, SIR and MSIR epidemic models
Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier
2014-01-01
International audience; We consider SIS, SIR and MSIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maxim...
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Competitive exclusion principle for SIS and SIR models with n strains
Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier
2012-01-01
We consider SIS and SIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maximum of each individual basic re...
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Montaigne, Sir Ralph Bankes and other English readers of the Essais.
O'Brien, John
2013-01-01
This article deals with a hitherto unknown and unpublished early modern English manuscript account of Montaigne's Essais by Sir Ralph Bankes (1631?–77) of Kingston Lacy in Dorset. Bankes's account covers a range of features in Montaigne's work: crucial elements of self-portraiture such as judgement, but also his attitude to women and doctors. These characteristics are analysed and compared first with Montaigne's own pronouncements about the aspects Bankes selects and secondly with two other s...
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[Vascular malformations in the Williams-Beuren syndrome: report of three new cases].
Sator, Hicham; Rhouni, Fatima Ezzahra; Benjouad, Ibitihale; Rhouni, Fatima Ezzahra; Benjouad, Ibitihale; Dafiri, Rachida; Chat, Latifa
2016-01-01
The Williams-Beuren syndrome is a rare genetic disease. It combines classically specific facial dysmorphism, cardiovascular malformations and specific neuropsychological profile. We report three cases of Williams-Beuren syndrome in children with particular emphasis on vascular abnormalities observed on CT angiography and MR angiography.
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SIR (Safe Integral Reactor) - reducing size can reduce cost
International Nuclear Information System (INIS)
Hayns, M.R.
1991-01-01
Traditional engineering economics have favoured the advantages of larger size as a means of reducing specific capital costs and hence unit generating costs. For large and small plants utilising the same concept, e.g. a small four-loop PWR vs a large four-loop PWR with the same number of components, economies of scale are well established. If, however, a smaller plant is sized to take advantage of features which are only feasible at smaller outputs, is of simpler design, with the advantage taken of the simplified design to produce the most cost-effective layout, and incorporates fewer, more easily replaceable components with minimal assembly on site, it is possible to produce a plant which is competitive with larger plant of more traditional design. When 'system' effects, such as better matching of installed capacity to the growth in demand and the fact that a smaller total capacity will be needed to meet a given demand with a specified level of confidence, are taken into account, it can be shown that a utility's overall cash-flow position can be improved with lower associated absolute financial risks. The UK/US Safe Integral Reactor (SIR) is an integral pressurized water reactor in the 300-400 MW(e) range which utilises conventional water reactor technology in a way not feasible at the very large, sizes of recent years. The SIR concept is briefly explained and its technical and economic advantages in terms of simplicity, construction, maintenance, availability, decommissioning, safety and siting described. The results of system analyses which demonstrate the overall financial advantages to a utility are presented. (author)
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Miglietta, Fabio; Faneschi, Maria Letizia; Lobreglio, Giambattista; Palumbo, Claudio; Rizzo, Adriana; Cucurachi, Marco; Portaccio, Gerolamo; Guerra, Francesco; Pizzolante, Maria
2015-09-01
The aim of this study was to evaluate procalcitonin (PCT), C-reactive protein (CRP), platelet count (PLT) and serum lactate dehydrogenase (LDH) as early markers for diagnosis of SIRS, bacterial sepsis and systemic candidiasis in intensive care unit (ICU) patients. Based on blood culture results, the patients were divided into a sepsis group (70 patients), a SIRS group (42 patients) and a systemic candidiasis group (33 patients). PCT, CRP, LDH and PLT levels were measured on day 0 and on day 2 from the sepsis symptom onset. PCT levels were higher in Gram negative sepsis than those in Gram positive sepsis, although the P value between the two subgroups is not significant (P=0.095). Bacterial sepsis group had higher PCT and CRP levels compared with the systemic candidiasis group, whereas PLT and LDH levels showed similar levels in these two subgroups. The AUC for PCT (AUC: 0.892, P candidiasis groups (P=0.093 N.S.). In conclusion, PCT can be used as a preliminary marker in the event of clinical suspicion of systemic candidiasis; however, low PCT levels (candidiasis and SIRS groups.
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Indian Academy of Sciences (India)
sharing personal experiences and viewpoints on matters related to teaching and learning science. ... School of Engineering and. Applied Sciences ... borative discovery (with Sir William Ramsay) of the inert elementary gas argon. Rayleigh's ..... J RA Pearson of the Imperial College of Science and Technology in London.
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Fevyer, David
2016-01-01
This thesis examines how six contemporary novels variously intervene in the current crisis of climate change. Through close readings of J G Ballard’s The Drowned World (1962) and Hello America (1981); Cormac McCarthy’s The Road (2006); Kurt Vonnegut’s Cat’s Cradle (1963) and Galapagos (1985); and Ian McEwan’s Solar (2010), the thesis aims to identify how the narrative and generic resources of contemporary fiction might help readers to think through and beyond the consequences of anthropocentr...
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Stranger Danger Awareness in Williams Syndrome
Riby, D. M.; Kirk, H.; Hanley, M.; Riby, L. M.
2014-01-01
Background: The developmental disorder Williams syndrome (WS) is characterised by a distinctive cognitive profile and an intriguing social phenotype. Individuals with the disorder are often highly social engaging with familiar and unfamiliar people and once in an interaction they often show subtle abnormalities of social behaviour. Atypically…
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Sir Ronald A. Fisher and the International Biometric Society.
Billard, Lynne
2014-06-01
The year 2012 marks the 50th anniversary of the death of Sir Ronald A. Fisher, one of the two Fathers of Statistics and a Founder of the International Biometric Society (the "Society"). To celebrate the extraordinary genius of Fisher and the far-sighted vision of Fisher and Chester Bliss in organizing and promoting the formation of the Society, this article looks at the origins and growth of the Society, some of the key players and events, and especially the roles played by Fisher himself as the First President. A fresh look at Fisher, the man rather than the scientific genius is also presented. © 2014, The International Biometric Society.
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33 CFR 164.43 - Automatic Identification System Shipborne Equipment-Prince William Sound.
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Automatic Identification System Shipborne Equipment-Prince William Sound. 164.43 Section 164.43 Navigation and Navigable Waters COAST GUARD... Automatic Identification System Shipborne Equipment—Prince William Sound. (a) Until December 31, 2004, each...
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Sex Complexity and Politics in Black Dogs by Ian McEwan
Abbasiyannejad, Mina; Talif, Rosli
Ian McEwan's Black Dogs (BD) is a story of socio-political conflict during the critical era of the Cold War. Black Dogs is riddled with party (political) domination and its outcomes in society. Europe is still suffering the consequences of the Second World War, perhaps the biggest war of the twentieth century. In the aftermath of such worldwide upheaval, the conflicts that were in tandem with the scramble for political domination emerged in diverse ways, affecting nations and their human populations. Systematic sexual assault during the war years showed that sex was used both for intimidation and humiliation. This study attempts to picture the multidimensional aspects of politics which are practically related to the most intimate human relationship, that is, sex. It pictures how personal is equated with the political and vice versa. The theory of sexual politics is the theoretical framework used to scrutinize power-structure relationship. By reviewing the major conflicts in such a scenario, as the Cold War, and societal restriction, this study concludes that conflict in the macrocosm (world and society) affects the microcosm (individual) in McEwan's Black Dogs. It provides a rather broad picture of politics and sexuality and highlights the stresses of wider society on human dysfunctional relationships. Rape as a tactic of war for a political goal demonstrates another aspect of sex. Reviewing the period in which the story takes place and relating it to the conflicts in society, the study goes beyond simple cause and effect problems among individuals and portrays a holistic view of sexuality and society.
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Investigating Environmentally Sustainable Transport Based on DALY weights and SIR Method
Directory of Open Access Journals (Sweden)
Hossein Nezamianpour Jahromi
2012-09-01
Full Text Available Accessibility is one of the main causes of well-being and growth in contemporary societies. Transportation is the backbone of accessibility systems that lead to the growth of economic and social networks and spatial dispersion of activities. Unfortunately, the adverse effects of transportation have a great impact on the natural and human environment. Since transportation is associated with fossil fuel combustion, it results in emissions of pollutants that cause damage to human health. To save the global eco-system, sustainable development has become an international priority. To deal with the sustainability of transportation systems is an important issue as testified by a growing number of initiatives framed to define and measure sustainability in transportation planning and infrastructure planning as well. The capability of environmental assessment as a sustainability instrument is well known. This study proposes a new approach to rank countries based on environmental sustainability development applying disability adjusted life year (DALY weights for transportation sector emissions. DALY weights consider actual impacts of pollutants on human health. By employing SIR method, a superiority and inferiority ranking method is presented for multiple criteria decision making, the sustainability ranking of a number of European countries is presented. Three various ranking methods extracted from SIR ranking method are discussed and the results and the correlation among them are demonstrated.
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Dynamic Behavior for an SIRS Model with Nonlinear Incidence Rate and Treatment
Directory of Open Access Journals (Sweden)
Junhong Li
2013-01-01
Full Text Available This paper considers an SIRS model with nonlinear incidence rate and treatment. It is assumed that susceptible and infectious individuals have constant immigration rates. We investigate the existence of equilibrium and prove the global asymptotical stable results of the endemic equilibrium. We then obtained that the model undergoes a Hopf bifurcation and existences a limit cycle. Some numerical simulations are given to illustrate the analytical results.
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N-acetylcysteine for neuropsychiatric symptoms in a woman with Williams syndrome.
Pineiro, Mildred Lopez; Roberts, Antoinette M; Waxler, Jessica L; Mullett, Jennifer E; Pober, Barbara R; McDougle, Christopher J
2014-11-01
Williams syndrome is a relatively rare genetic disorder caused by the hemizygous microdeletion of a region in chromosome 7q11.23. Individuals with Williams syndrome typically present with a highly social, overfriendly, and empathic personality. Comorbid medical and neuropsychiatric disorders are common. Reports of effective pharmacological treatment of associated neuropsychiatric disorders are limited. The authors describe the successful treatment of interfering anger, aggression, and hair-pulling with N-acetylcysteine in a 19-year-old woman with Williams syndrome. The neuropsychiatric symptoms emerged 1 week following an upper gastrointestinal endoscopy, for which fentanyl, midazolam, and propofol were used as anesthetics. The patient's treatment course and hypothesized mechanisms underlying the clinical presentation and symptom resolution are described. © The Author(s) 2014.
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Fading-Figure Tracing in Williams Syndrome
Nagai, Chiyoko; Inui, Toshio; Iwata, Makoto
2011-01-01
Williams syndrome (WS) is a neurodevelopmental disorder characterized by severe impairment of visuospatial abilities. Figure-drawing abilities, which are thought to reflect visuospatial abilities, have yet to be fully investigated in WS. The purpose of the present study was to clarify whether drawing abilities differ between WS individuals and…
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2012-07-24
...; William D. Ford Federal Direct Loan Program General Forbearance Request SUMMARY: Borrowers who receive loans through the William D. Ford Federal Direct Loan Program will use this form to request forbearance... considered public records. Title of Collection: William D. Ford Federal Direct Loan Program General...
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Seasonal distribution of Dall's porpoise in Prince William Sound, Alaska
Moran, John R.; O'Dell, Matthew B.; Arimitsu, Mayumi L.; Straley, Janice M.; Dickson, Danielle M. S.
2018-01-01
Dall's porpoise, Phocoenoides dalli, are a conspicuous predator in the Prince William Sound ecosystem, yet there has been little effort directed towards monitoring this species since the 1980s, prior to the Exxon Valdez oil spill. We used vessel-based surveys to examine the seasonal distribution of Dall's porpoise in the waters of Prince William Sound during eight years from 2007 to 2015. Over the course of 168 days and 15,653 km of survey effort, 921 Dall's porpoise were encountered in 210 groups. We estimate an encounter rate of 0.061 porpoise/km traveled or 1 porpoise encountered for every 16.5 km traveled. Dall's porpoise were found throughout the year in Prince William Sound, and used a wide range of habitats, including those not considered typical of the species, such as bays, shallow water, and nearshore waters. Dall's porpoise seasonally shifted their center of distribution from the western passages in fall to the bays of the eastern Sound in winter and spring. Dall's porpoises were widely dispersed throughout the Sound in summer. We identified potential Dall's porpoise habitat (depth, slope, and distance from shore) within Prince William Sound using generalized additive models (GAM). Dall's porpoise were found in deeper water during summer and in shallowest water during spring. We propose that their use of novel habitats is a function of reduced predation risk associated with the decline of their main predator, killer whales (Orcinus orca), following the Exxon Valdez oil spill, and the presence of overwintering and spawning Pacific herring (Clupea pallasii). While the size of the Dall's porpoise population within Prince William Sound remains unknown, our encounter rates were lower than those reported in the 1970s. Their high metabolic rate and ubiquitous presence makes them one of the more important, yet understudied, forage fish predators in the region.
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Williams-Beuren syndrome associated with single kidney and nephrocalcinosis: a case report.
Abidi, Kamel; Jellouli, Manel; Ben Rabeh, Rania; Hammi, Yousra; Gargah, Tahar
2015-01-01
Williams-Beuren syndrome is a rare neurodevelopmental disorder, characterized by congenital heart defects, abnormal facial features, mental retardation with specific cognitive and behavioral profile, growth hormone deficiency, renal and skeletal anomalies, inguinal hernia, infantile hypercalcaemia. We report a case with Williams-Beuren syndrome associated with a single kidney and nephrocalcinosis complicated by hypercalcaemia. A male infant, aged 20 months presented growth retardation associated with a psychomotor impairment, dysmorphic features and nephrocalcinosis. He had also hypercalciuria and hypercalcemia. Echocardiography was normal. DMSA renal scintigraphy showed a single functioning kidney. The FISH generated one ELN signal in 20 metaphases read and found the presence of ELN deletion, with compatible Williams-Beuren syndrome.
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2012-08-08
...; William D. Ford Federal Direct Loan (Direct Loan) Program/ Federal Family Loan (FFEL) Program: Deferment... which borrowers in the William D. Ford Federal Direct Loan (Direct Loan) and Federal Family Education... considered public records. Title of Collection: William D. Ford Federal Direct Loan (Direct Loan) Program...
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MRI Amygdala Volume in Williams Syndrome
Capitao, Liliana; Sampaio, Adriana; Sampaio, Cassandra; Vasconcelos, Cristiana; Fernandez, Montse; Garayzabal, Elena; Shenton, Martha E.; Goncalves, Oscar F.
2011-01-01
One of the most intriguing characteristics of Williams Syndrome individuals is their hypersociability. The amygdala has been consistently implicated in the etiology of this social profile, particularly given its role in emotional and social behavior. This study examined amygdala volume and symmetry in WS individuals and in age and sex matched…
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Attention to Faces in Williams Syndrome
Riby, Deborah M.; Jones, Nicola; Brown, Philippa H.; Robinson, Lucy J.; Langton, Stephen R. H.; Bruce, Vicki; Riby, Leigh M.
2011-01-01
Williams syndrome (WS) is associated with distinct social behaviours. One component of the WS social phenotype is atypically prolonged face fixation. This behaviour co-exists with attention difficulties. Attention is multi-faceted and may impact on gaze behaviour in several ways. Four experiments assessed (i) attention capture by faces, (ii)…
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Lyapunov functions and global stability for SIR and SEIR models with age-dependent susceptibility
Korobeinikov, Andrei; Melnik, Andrey V.
2013-01-01
We consider global asymptotic properties for the SIR and SEIR age structured models for infectious diseases where the susceptibility depends on the age. Using the direct Lyapunov method with Volterra type Lyapunov functions, we establish conditions for the global stability of a unique endemic steady state and the infection-free steady state.
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International Nuclear Information System (INIS)
Sarta Fuentes, Jose A.; Castiblanco, L.A.
2003-01-01
With cooperation of the International Atomic Energy Agency (IAEA), neutronic calculations were carried out for conversion of the Ian-R1 Reactor from MTR-HEU fuel to TRIGA-LEU fuel. In order to establish a staff for neutronic calculation at the Instituto de Cancan's Nucleares y Energia s Alternatives (INEA) a program was established. This program included training, acquisition of hardware, software and calculation for the core with MTR-HEU fuel , enriched nominally to 93% and calculation for several arrangements with the TRIGA-LEU fuel, enriched to 19.7%. The results were verified and compared with several groups of calculation at the Instituto Nacional de Investigaciones Nucleares (ININ) in Mexico, and General Atomics (GA) in United States. As a result of this program, several technical reports have been wrote. (author)
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Enough room for Williams and IMF? / Paul Beckman
Beckman, Paul
1999-01-01
Lõppesid Leedu ja USA energeetikakompanii Williams International läbirääkimised Leedu naftakompleksis osaluse omandamise asjus. IMF uurib Leedu majanduslikku arengut, mida tehing Williamsiga komplitseerib
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2013-01-25
... DEPARTMENT OF EDUCATION Annual Notice of Interest Rates of Federal Student Loans Made Under the... amended, the Chief Operating Officer for Federal Student Aid announces the interest rates for the period... interest rates to the public. FOR FURTHER INFORMATION CONTACT: Ian Foss, U.S. Department of Education, 830...
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ABORDAGEM DIAGNÓSTICA DA SÍNDROME DE WILLIAMS - BEUREN.
Santos, Marina Machado
2016-01-01
As anomalias cromossômicas causam fenótipos específicos e complexos resultantes de desequilíbrios na dose normal de genes localizados em um segmento cromossômico específico, sendo responsáveis por 60 % ou mais das síndromes genéticas identificáveis. A Síndrome de Williams-Beuren (SWB) caracteriza-se por anomalias múltiplas e deficiência intelectual, descrita independentemente por Williams et al. (1961) e por Beuren et al. (1962). A SWB consiste em uma doença genética causada pela microdeleção...
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Carrera, Mónica; Gallardo, José M
2017-02-08
The determination of the geographical origin of food products is relevant to comply with the legal regulations of traceability, to avoid food fraud, and to guarantee food quality and safety to the consumers. For these reasons, stable isotope ratio (SIR) analysis using an isotope ratio mass spectrometry (IRMS) instrument is one of the most useful techniques for evaluating food traceability and authenticity. The present study was aimed to determine, for the first time, the geographical origin for all commercial fish species belonging to the Merlucciidae family using SIR analysis of carbon (δ 13 C) and nitrogen (δ 15 N). The specific results enabled their clear classification according to the FAO (Food and Agriculture Organization of the United Nations) fishing areas, latitude, and geographical origin in the following six different clusters: European, North African, South African, North American, South American, and Australian hake species.
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International Nuclear Information System (INIS)
Avila-Rodriguez, Miguel A.; Selwyn, Reed G.; Hampel, Joseph A.; Thomadsen, Bruce R.; DeJesus, Onofre T.; Converse, Alexander K.; Nickles, Robert J.
2007-01-01
Commercially available resin microspheres and SIR-Spheres were labeled with metallic positron emitters and evaluated as positron emission tomography (PET) imaging surrogates of 90 Y SIR-Spheres. Radiolabeling was performed using a batch method, and in vitro stability over 24 h was evaluated in saline at physiological pH at 37 o C. The activity per microsphere distribution, as evaluated by autoradiography, showed the activity per microsphere to be proportional to the square radius of the spheres, suggesting surface binding. The in vivo stability of radiolabeling was evaluated in rats by micro-PET imaging after the intravenous injection of labeled microspheres. The different resin microspheres and radionuclides evaluated in this study all showed good radiolabeling efficiency and in vitro stability. However, only resins labeled with 86 Y and 89 Zr proved to have the in vivo stability required for clinical applications
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The threshold of a stochastic delayed SIR epidemic model with temporary immunity
Liu, Qun; Chen, Qingmei; Jiang, Daqing
2016-05-01
This paper is concerned with the asymptotic properties of a stochastic delayed SIR epidemic model with temporary immunity. Sufficient conditions for extinction and persistence in the mean of the epidemic are established. The threshold between persistence in the mean and extinction of the epidemic is obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number R0 of the deterministic system.
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Sir Winston Churchill: treatment for pneumonia in 1943 and 1944.
Vale, J A; Scadding, J W
2017-12-01
This paper reviews Churchill's illnesses in February 1943 and August/September 1944 when he developed pneumonia; on the first occasion this followed a cold and sore throat. Churchill was managed at home by Sir Charles Wilson (later Lord Moran) with the assistance of two nurses and the expert advice of Dr Geoffrey Marshall, Brigadier Lionel Whitby and Colonel Robert Drew. A sulphonamide (sulphathiazole on the first occasion) was prescribed for both illnesses. Churchill recovered, and despite his illnesses continued to direct the affairs of State from his bed. On the second occasion, Churchill's illness was not made public.
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Florence Jessie Mac Williams (1917-1990)
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education; Volume 10; Issue 1. Florence Jessie Mac Williams (1917-1990). Featured Scientist Volume 10 Issue 1 January 2005 pp 98-98. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/010/01/0098-0098. Resonance ...
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Directory of Open Access Journals (Sweden)
Inbal Nussbaum
Full Text Available Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood, although deteriorated stress response is one of the hallmarks of aging. The budding yeast Saccharomyces cerevisiae is a valuable model organism to study the genetics of aging, because yeast ages within days and are amenable to genetic manipulations. As a unicellular organism, yeast has evolved robust systems to respond to environmental challenges. This response is orchestrated largely by the conserved transcription factor Hsf1, which in S. cerevisiae regulates expression of multiple genes in response to diverse stresses. Here we demonstrate that Hsf1 response to heat shock and oxidative stress deteriorates during yeast transition from exponential growth to stationary-phase, whereas Hsf1 activation by glucose starvation is maintained. Overexpressing Hsf1 does not significantly improve heat shock response, indicating that Hsf1 dwindling is not the major cause for Hsf1 attenuated response in stationary-phase yeast. Rather, factors that participate in Hsf1 activation appear to be compromised. We uncover two factors, Yap1 and Sir2, which discretely function in Hsf1 activation by oxidative stress and heat shock. In Δyap1 mutant, Hsf1 does not respond to oxidative stress, while in Δsir2 mutant, Hsf1 does not respond to heat shock. Moreover, excess Sir2 mimics the heat shock response. This role of the NAD+-dependent Sir2 is supported by our finding that supplementing NAD+ precursors improves Hsf1 heat shock response in stationary-phase yeast, especially when combined with expression of excess Sir2. Finally, the combination of excess Hsf1, excess Sir2 and NAD+ precursors rejuvenates the heat shock response.
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Nussbaum, Inbal; Weindling, Esther; Jubran, Ritta; Cohen, Aviv; Bar-Nun, Shoshana
2014-01-01
Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood, although deteriorated stress response is one of the hallmarks of aging. The budding yeast Saccharomyces cerevisiae is a valuable model organism to study the genetics of aging, because yeast ages within days and are amenable to genetic manipulations. As a unicellular organism, yeast has evolved robust systems to respond to environmental challenges. This response is orchestrated largely by the conserved transcription factor Hsf1, which in S. cerevisiae regulates expression of multiple genes in response to diverse stresses. Here we demonstrate that Hsf1 response to heat shock and oxidative stress deteriorates during yeast transition from exponential growth to stationary-phase, whereas Hsf1 activation by glucose starvation is maintained. Overexpressing Hsf1 does not significantly improve heat shock response, indicating that Hsf1 dwindling is not the major cause for Hsf1 attenuated response in stationary-phase yeast. Rather, factors that participate in Hsf1 activation appear to be compromised. We uncover two factors, Yap1 and Sir2, which discretely function in Hsf1 activation by oxidative stress and heat shock. In Δyap1 mutant, Hsf1 does not respond to oxidative stress, while in Δsir2 mutant, Hsf1 does not respond to heat shock. Moreover, excess Sir2 mimics the heat shock response. This role of the NAD+-dependent Sir2 is supported by our finding that supplementing NAD+ precursors improves Hsf1 heat shock response in stationary-phase yeast, especially when combined with expression of excess Sir2. Finally, the combination of excess Hsf1, excess Sir2 and NAD+ precursors rejuvenates the heat shock response.
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Shen, Pengfei; Wei, Wuran; Yang, Xiaochun; Zeng, Hao; Li, Xiong; Yang, Jie; Wang, Jia; Huang, Jiaoti
2010-10-01
The objective of this study is to investigate the influences of percutaneous nephrolithotomy (PNL) and open surgery nephrolithotomy on the systemic stress response, SIRS and renal function. Forty patients with kidney calculi were enrolled in the study. Twenty cases were randomized to the PNL group and the other twenty cases to the open surgery group. Levels of C-reactive protein (CRP), interleukin-6(IL-6), β(2)-microglobulin (β(2)-MG), respiration rate, heart rate, body temperature and white blood cell counts were examined. CRP and IL-6 were measured in all patients pre-operatively and on post-operative days 1, 3 and 6, respectively. There was significant difference in their pre- and post-operation levels (P PNL group and 12 cases in open surgery group; there was significant difference between the two groups (P 0.05). Urine β(2)-MG levels were also measured. There was significant difference between pre- and the first day post-PNL (P PNL (P > 0.05). There was significant difference between pre- and first and third day post-open surgery (P 0.05). There was significant difference between two groups at the first, third and sixth days (P PNL group and open surgery group to some extent. The degree of stress response of PNL is lower than that of open surgery, proving the advantages of PNL with reference to serum immunology. There were cases in both the groups with SIRS, but the degree of SIRS in PNL group was lesser than the other group. Both the groups have no obvious effect on glomerular filtration function after operation and have effect on renal tubular reabsorption in the early stage after operation; but the recovery of the PNL group is faster than the open surgery group. It is thus shown that PNL is much safer and more feasible and has lesser effect on renal function.
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Outcome in Adult Life for People with Williams Syndrome Results from a Survey of 239 Families
Howlin, P.; Udwin, O.
2006-01-01
BACKGROUND: Although there has been considerable research into the genotype and phenotype of Williams syndrome, there have been relatively few studies of long-term prognosis. As a preliminary to a more detailed investigation of adults with Williams syndrome, a parental questionnaire was distributed to members of the UK Williams Syndrome…
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Coronary ostium occlusion by coronary cusp displacement in Williams syndrome.
Shiohama, Tadashi; Fujii, Katsunori; Ebata, Ryota; Funabashi, Nobusada; Matsumiya, Goro; Saito, Yuko Kazato; Takechi, Fumie; Yonemori, Yoko; Nakatani, Yukio; Shimojo, Naoki
2016-06-01
Williams syndrome is a contiguous gene deletion syndrome resulting from a heterozygous deletion on chromosome 7q11.23, and is characterized by distinctive facial features and supravalvular aortic stenosis (SVAS). This syndrome rarely presents unpredictable cardiac death, and yet, as illustrated in the present case, it is still not possible to predict it, even on close monitoring. We herein describe the case of a 6-year-old Japanese girl with Williams syndrome, who had sudden cardiac collapse due to cardiac infarction after pharyngitis. Cardiac failure followed a critical course that did not respond to catecholamine support or heart rest with extracardiac mechanical support. Although marked coronary stenosis was not present, the left coronary cusp abnormally adhered to the aortic wall, which may synergistically cause coronary ostium occlusion with SVAS. Altered hemodynamic state, even that caused by the common cold, may lead to critical myocardial events in Williams syndrome with SVAS. © 2015 Japan Pediatric Society.
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Medicinal use of earths and minerals from Hippocrates to Sir Hans Sloane and beyond.
Retsas, Spyros
2012-12-01
In 1931 two pharmaceutical drawers containing mineral specimens, belonging to Sir Hans Sloane, the 18th century collector, Royal Physician, President of the Royal Society and of the Royal College of Physicians of London, were found in the Department of Botany of the Natural History Museum (NHM) of London. The drawers, each divided into 49 compartments, contained a total of 107 mineral pharmaceutical specimens, some labelled as mercury or white arsenic. Their registration, identification with the Sloane Manuscript Catalogues and subsequent transfer to the Mineralogy department of the NHM where one of these drawers is now on public display, had been documented by 1935. In antiquity therapeutic empiricism attributed medicinal properties to animal products, plants and minerals, including the soil of specific geographic locations. This communication traces the medicinal use of certain earths and minerals, listed in Sir Hans Sloane's manuscript catalogues, to classical antiquity with a reference to Arsenic compounds, which in our time are finding application in the treatment of acute promyelocytic leukaemia and to Terra Lemnia, a celebrated antidote of repute spanning twenty centuries, also included in the Sloane collections.
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The Threshold of a Stochastic SIRS Model with Vertical Transmission and Saturated Incidence
Directory of Open Access Journals (Sweden)
Chunjuan Zhu
2017-01-01
Full Text Available The threshold of a stochastic SIRS model with vertical transmission and saturated incidence is investigated. If the noise is small, it is shown that the threshold of the stochastic system determines the extinction and persistence of the epidemic. In addition, we find that if the noise is large, the epidemic still prevails. Finally, numerical simulations are given to illustrate the results.
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Traveling waves in a delayed SIR model with nonlocal dispersal and nonlinear incidence
Zhang, Shou-Peng; Yang, Yun-Rui; Zhou, Yong-Hui
2018-01-01
This paper is concerned with traveling waves of a delayed SIR model with nonlocal dispersal and a general nonlinear incidence. The existence and nonexistence of traveling waves of the system are established respectively by Schauder's fixed point theorem and two-sided Laplace transform. It is also shown that the spread speed c is influenced by the dispersal rate of the infected individuals and the delay τ.
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The scientific legacy of William Herschel
2018-01-01
This book presents a modern scholarly analysis of issues associated with England’s most famous astronomer, William Herschel. The world’s leading experts on Herschel, discoverer of the planet Uranus, here offer their combined wisdom on many aspects of his life and astronomical research. Solar system topics include comets, Earth’s Moon, and the spurious moons of Uranus, all objects whose observation was pioneered by Herschel. The contributors examine his study of the structure of the Milky Way and an in-depth look at the development of the front view telescopes he built. The popular subject of extraterrestrial life is looked at from the point of view of both William Herschel and his son John, both of whom had an interest in the topic. William’s personal development through the educational system of the late eighteenth-century is also explored, and the wide range of verse and satire in various languages associated with his discoveries is collected here for the first time. Hershel worked at a time of i...
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Directory of Open Access Journals (Sweden)
K. Vardas
2014-01-01
Full Text Available Objective. To evaluate the early heat shock protein (HSP and hormonal stress response of intensive care unit (ICU patients with severe sepsis/septic shock (SS or systemic inflammatory response syndrome (SIRS compared to healthy subjects (H. Methods. Patients with early (first 48 hrs SS (n=29 or SIRS (n=29 admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72 and interleukins. Mean fluorescence intensity (MFI values for intracellular HSPs (iHSP72, iHSP90α were measured using 4-colour flow-cytometry. Results. Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H (P<0.003. ACTH and eHSP72 were significantly higher in SS and SIRS compared to H (P<0.005. SS monocytes expressed lower iHSP72 MFI levels compared to H (P=0.03. Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate (P<0.05. In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10. Conclusion. Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.
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Holocene deposition and megathrust splay fault geometries within Prince William Sound, Alaska
Finn, S.; Liberty, L. M.; Haeussler, P. J.; Pratt, T. L.
2011-12-01
New high resolution sparker seismic reflection data, in conjunction with reprocessed legacy seismic data, provide the basis for a new fault, fold, and Holocene sediment thickness database for Prince William Sound, Alaska. Additionally, legacy airgun seismic data in Prince William Sound and the Gulf of Alaska tie features on these new sparker data to deeper portions of megathrust splay faults. We correlate regionally extensive bathymetric lineaments within Prince William Sound to megathrust splay faults, such as the ones that ruptured in the 1964 M9.2 earthquake. Lastly, we estimate Holocene sediment thickness within Prince William Sound to better constrain the Holocene fault history throughout the region. We identify three seismic facies related to Holocene, Quaternary, and Tertiary strata that are crosscut by numerous high angle normal faults in the hanging wall of the megathrust splay faults. The crustal-scale seismic reflection profiles show splay faults emerging from 20 km depth between the Yakutat block and North American crust and surfacing as the Hanning Bay and Patton Bay faults. A change in exhumation rates, slip rates, and fault orientation appears near Hinchinbrook that we attribute to differences in subducted slab geometry. Based on our slip rate analysis, we calculate average Holocene displacements of 20 m and 100 m in eastern and western Prince William Sound, respectively. Landward of two splay faults exposed on Montague Island, we observe subsidence, faulting, and landslides that record deformation associated with the 1964 and older megathrust earthquakes.
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March 1964 Prince William Sound, USA Images
National Oceanic and Atmospheric Administration, Department of Commerce — The Prince William Sound magnitude 9.2 Mw earthquake on March 28, 1964 at 03:36 GMT (March 27 at 5:36 pm local time), was the largest U.S. earthquake ever recorded...
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Attentional Disengagement in Adults with Williams Syndrome
Lense, Miriam D.; Key, Alexandra P.; Dykens, Elisabeth M.
2011-01-01
Williams syndrome (WS) is a neurodevelopmental disorder characterized by a distinctive behavioral and cognitive profile, including widespread problems with attention. However, the specific nature of their attentional difficulties, such as inappropriate attentional allocation and/or poor attentional disengagement abilities, has yet to be…
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Sleep-EEG in dizygotic twins discordant for Williams syndrome.
Bódizs, Róbert; Gombos, Ferenc; Szocs, Katalin; Réthelyi, János M; Gerván, Patrícia; Kovács, Ilona
2014-01-30
Reports on twin pairs concordant and discordant for Williams syndrome were published before, but no study unravelled sleep physiology in these cases yet. We aim to fill this gap by analyzing sleep records of a twin pair discordant for Williams syndrome extending our focus on presleep wakefulness and sleep spindling. We performed multiplex ligation-dependent probe amplification of the 7q11.23 region of a 17 years old dizygotic opposite-sex twin pair discordant for Williams syndrome. Polysomnography of laboratory sleep at this age was analyzed and followed-up after 1.5 years by ambulatory polysomnography. Sleep stages scoring, EEG power spectra and sleep spindle analyses were carried out. The twin brother showed reduced levels of amplification for all of the probes in the 7q11.23 region indicating a typical deletion spanning at least 1.038 Mb between FKBP6 and CLIP2. The results of the twin sister showed normal copy numbers in the investigated region. Lower sleep times and efficiencies, as well as higher slow wave sleep percents of the twin brother were evident during both recordings. Roughly equal NREM, Stage 2 and REM sleep percents were found. EEG analyses revealed state and derivation-independent decreases in alpha power, lack of an alpha spectral peak in presleep wakefulness, as well as higher NREM sleep sigma peak frequency in the twin brother. Faster sleep spindles with lower amplitude and shorter duration characterized the records of the twin brother. Spectra show a striking reliability and correspondence between the two situations (laboratory vs. home records). Alterations in sleep and specific neural oscillations including the alpha/sigma waves are inherent aspects of Williams syndrome.
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Auditory Attraction: Activation of Visual Cortex by Music and Sound in Williams Syndrome
Thornton-Wells, Tricia A.; Cannistraci, Christopher J.; Anderson, Adam W.; Kim, Chai-Youn; Eapen, Mariam; Gore, John C.; Blake, Randolph; Dykens, Elisabeth M.
2010-01-01
Williams syndrome is a genetic neurodevelopmental disorder with a distinctive phenotype, including cognitive-linguistic features, nonsocial anxiety, and a strong attraction to music. We performed functional MRI studies examining brain responses to musical and other types of auditory stimuli in young adults with Williams syndrome and typically…
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Florence Jessie MacWilliams (1917-1990)
Indian Academy of Sciences (India)
famous mathematician Oscar Zariski, well known for his work in algebraic geometry, at. Johns Hopkins University, following him to Harvard University to study with him for a year. There was a break in her studies for many years following her marriage in 1941 to. W al ter Mac Williams, an engineer, and the birth and raising of ...
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Prince William Sound, Alaska ESI: FISH (Fish Polygons)
National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) data for Prince William Sound, Alaska. ESI data characterize estuarine environments and wildlife by...
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Prince William Sound, Alaska ESI: NESTS (Bird Nests)
National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) data for Prince William Sound, Alaska. ESI data characterize estuarine environments and wildlife by...
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The threshold of a stochastic delayed SIR epidemic model with vaccination
Liu, Qun; Jiang, Daqing
2016-11-01
In this paper, we study the threshold dynamics of a stochastic delayed SIR epidemic model with vaccination. We obtain sufficient conditions for extinction and persistence in the mean of the epidemic. The threshold between persistence in the mean and extinction of the stochastic system is also obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number Rbar0 of the deterministic system. Results show that time delay has important effects on the persistence and extinction of the epidemic.
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William Shakespeare’s“Hamlet”and Oedipus Complex
Institute of Scientific and Technical Information of China (English)
迪丽努尔
2014-01-01
“Hamlet”is one of the great dramas of William Shakespeare. This paper by describing the relationship between Hamlet and his mother, the Ghost and his uncle, tries to approve that Oedipus complex is the main reason of Hamlet’s kil ing his uncle.
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De wereld in 18 lessen: Christopher Williams
Berrebi, S.
2011-01-01
Hij is een echte artist’s artist, de conceptuele fotograaf Christopher Williams. Sinds hij in Duitsland woont en werkt, vindt zijn afgewogen werk, dat de fotografie tegelijk eert en ondervraagt, steeds makkelijker onderdak in Europese kunstinstituten, zoals dit voorjaar bij Museum Dhondt-Dhaenens in
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A case of William's syndrome associated peripheral pulmonary arterial stenosis
Energy Technology Data Exchange (ETDEWEB)
Jung, Kyung Hwa; Hwang, Mi Soo; Kim, Sun Yong; Chang, Jae Chun; Park, Bok Hwan [College of Medicine, Yeungam University, Daegu (Korea, Republic of)
1988-06-15
William's syndrome, in order to more completely delineate the total spectrum of the disorder, indicates that 'infantile hypercalcemia', 'peculiar facies' and 'supravalvular aortic stenosis.' In has other many vascular anomalies, such as peripheral pulmonary arterial stenosis, coronary arterial stenosis, celiac arterial stenosis, and renal aterial stenosis. Only 32% of the patients have evidence of supravalvular aortic stenosis. And it is very rare disease entity that has been reported rarely in Korea. Recently authors experienced a case that was questioned William's syndrome with peripheral pulmonary arterial stenosis, clinically and preliminary radiologically and this case was confirmed by operation. Here we report a case of William's syndrome with peripheral pulmonary arterial stenosis and reviewed literatures.
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An individual-based approach to SIR epidemics in contact networks.
Youssef, Mina; Scoglio, Caterina
2011-08-21
Many approaches have recently been proposed to model the spread of epidemics on networks. For instance, the Susceptible/Infected/Recovered (SIR) compartmental model has successfully been applied to different types of diseases that spread out among humans and animals. When this model is applied on a contact network, the centrality characteristics of the network plays an important role in the spreading process. However, current approaches only consider an aggregate representation of the network structure, which can result in inaccurate analysis. In this paper, we propose a new individual-based SIR approach, which considers the whole description of the network structure. The individual-based approach is built on a continuous time Markov chain, and it is capable of evaluating the state probability for every individual in the network. Through mathematical analysis, we rigorously confirm the existence of an epidemic threshold below which an epidemic does not propagate in the network. We also show that the epidemic threshold is inversely proportional to the maximum eigenvalue of the network. Additionally, we study the role of the whole spectrum of the network, and determine the relationship between the maximum number of infected individuals and the set of eigenvalues and eigenvectors. To validate our approach, we analytically study the deviation with respect to the continuous time Markov chain model, and we show that the new approach is accurate for a large range of infection strength. Furthermore, we compare the new approach with the well-known heterogeneous mean field approach in the literature. Ultimately, we support our theoretical results through extensive numerical evaluations and Monte Carlo simulations. Published by Elsevier Ltd.
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McClure, Julie M.; Wierman, Margaret B.; Maqani, Nazif; Smith, Jeffrey S.
2012-01-01
Sirtuins are an evolutionarily conserved family of NAD+-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD+ concentration through the combined action of NAD+ biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD+ precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the nicotinamidase Pnc1 converts NAM to nicotinic acid (NA), which is then used as a substrate by the NAD+ salvage pathway enzyme NA phosphoribosyltransferase (Npt1). Isonicotinamide (INAM) is an isostere of NAM that stimulates yeast Sir2 deacetylase activity in vitro by alleviating the NAM inhibition. In this study, we determined that INAM stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD+ concentration. INAM enhanced normal silencing at the rDNA locus but only partially suppressed the silencing defects of an npt1Δ mutant. Yeast cells grown in media lacking NA had a short replicative life span, which was extended by INAM in a SIR2-dependent manner and correlated with increased NAD+. The INAM-induced increase in NAD+ was strongly dependent on Pnc1 and Npt1, suggesting that INAM increases flux through the NAD+ salvage pathway. Part of this effect was mediated by the NR salvage pathways, which generate NAM as a product and require Pnc1 to produce NAD+. We also provide evidence suggesting that INAM influences the expression of multiple NAD+ biosynthesis and salvage pathways to promote homeostasis during stationary phase. PMID:22539348
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McClure, Julie M; Wierman, Margaret B; Maqani, Nazif; Smith, Jeffrey S
2012-06-15
Sirtuins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD(+) concentration through the combined action of NAD(+) biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD(+) precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the nicotinamidase Pnc1 converts NAM to nicotinic acid (NA), which is then used as a substrate by the NAD(+) salvage pathway enzyme NA phosphoribosyltransferase (Npt1). Isonicotinamide (INAM) is an isostere of NAM that stimulates yeast Sir2 deacetylase activity in vitro by alleviating the NAM inhibition. In this study, we determined that INAM stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD(+) concentration. INAM enhanced normal silencing at the rDNA locus but only partially suppressed the silencing defects of an npt1Δ mutant. Yeast cells grown in media lacking NA had a short replicative life span, which was extended by INAM in a SIR2-dependent manner and correlated with increased NAD(+). The INAM-induced increase in NAD(+) was strongly dependent on Pnc1 and Npt1, suggesting that INAM increases flux through the NAD(+) salvage pathway. Part of this effect was mediated by the NR salvage pathways, which generate NAM as a product and require Pnc1 to produce NAD(+). We also provide evidence suggesting that INAM influences the expression of multiple NAD(+) biosynthesis and salvage pathways to promote homeostasis during stationary phase.
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Microstrip Cross-coupled Interdigital SIR Based Bandpass Filter
Directory of Open Access Journals (Sweden)
R. K. Maharjan
2012-09-01
Full Text Available A simple and compact 4.9 GHz bandpass filter for C-band applications is proposed. This paper presents a novel microstrip cross-coupled interdigital half-wavelength stepped impedance resonator (SIR based bandpass filter (BPF.The designed structure is similar to that of a combination of two parallel interdigital capacitors. The scattering parameters of the structure are measured using vector network analyzer (VNA. The self generated capacitive and inductive reactances within the interdigital resonators exhibited in a resonance frequency of 4.9 GHz. The resonant frequency and bandwidth of the capacitive cross-coupled resonator is directly optimized from the physical arrangement of the resonators. The measured insertion loss (S21 and return loss (S11 were 0.3 dB and 28 dB, respectively, at resonance frequency which were almost close to the simulation results.
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DEFF Research Database (Denmark)
Simonsen, Peter
William Wordsworth, posterity, reading, material inscription, ekphrasis, description, sonnet, portraiture......William Wordsworth, posterity, reading, material inscription, ekphrasis, description, sonnet, portraiture...
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Van de Graaf, Robert C.; Ijpma, Frank F. A.; Nicolai, Jean-Philippe A.
Sir Charles Ballance (1856-1936) was the first surgeon in history to perform a facial nerve crossover anastomosis in 1895. Although, recently, several papers on the history of facial nerve surgery have been published, little is known about this historically important operation, the theoretical
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How Would Blackstone Teach Today's Law Students with Learning Disabilities?: A Proposal
Schmitz, Suzanne J.
2007-01-01
Although Sir William Blackstone would not have known if he had been lecturing to students with learning disabilities, today's law professors are. Law schools are legally required to accommodate students with learning disabilities unless the requested accommodation would alter the fundamental nature of the program. Courts give great deference to…
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Ha, Cheol Woong; Kim, Kwantae; Chang, Yeon Ji; Kim, Bongkeun; Huh, Won-Ki
2014-07-01
In Saccharomyces cerevisiae, the stability of highly repetitive rDNA array is maintained through transcriptional silencing. Recently, a β-1,3-glucanosyltransferase Gas1 has been shown to play a significant role in the regulation of transcriptional silencing in S. cerevisiae. Here, we show that the gas1Δ mutation increases rDNA silencing in a Sir2-dependent manner. Remarkably, the gas1Δ mutation induces nuclear localization of Msn2/4 and stimulates the expression of PNC1, a gene encoding a nicotinamidase that functions as a Sir2 activator. The lack of enzymatic activity of Gas1 or treatment with a cell wall-damaging agent, Congo red, exhibits effects similar to those of the gas1Δ mutation. Furthermore, the loss of Gas1 or Congo red treatment lowers the cAMP-dependent protein kinase (PKA) activity in a cell wall integrity MAP kinase Slt2-dependent manner. Collectively, our results suggest that the dysfunction of Gas1 plays a positive role in the maintenance of rDNA integrity by decreasing PKA activity and inducing the accumulation of Msn2/4 in the nucleus. It seems that nuclear-localized Msn2/4 stimulate the expression of Pnc1, thereby enhancing the association of Sir2 with rDNA and promoting rDNA stability. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.
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Sir Robert Ball: Victorian Astronomer and Lecturer par excellence
Jones, R. I. G.
2005-12-01
Between 1875 and 1910 Sir Robert Stawell Ball gave an estimated 2,500 lectures in towns and cities all over the British Isles and abroad. This paper traces his lecturing career from its beginnings in Ireland to the triumphs of the Royal Institution, and on lecture tours in the United States of America. After a period in mathematics and mechanics, he became a populariser of science, especially astronomy, and found fame and fortune among the working classes and the aristocracy. What motivated him to tireless travels is uncertain, but it might have been that it was rewarding, financially and to his reputation. Whatever his motives, contemporary accounts are clear that BallÕs lectures were extremely popular and well-received.
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Colour discrimination and categorisation in Williams syndrome.
Farran, Emily K; Cranwell, Matthew B; Alvarez, James; Franklin, Anna
2013-10-01
Individuals with Williams syndrome (WS) present with impaired functioning of the dorsal visual stream relative to the ventral visual stream. As such, little attention has been given to ventral stream functions in WS. We investigated colour processing, a predominantly ventral stream function, for the first time in nineteen individuals with Williams syndrome. Colour discrimination was assessed using the Farnsworth-Munsell 100 hue test. Colour categorisation was assessed using a match-to-sample test and a colour naming task. A visual search task was also included as a measure of sensitivity to the size of perceptual colour difference. Results showed that individuals with WS have reduced colour discrimination relative to typically developing participants matched for chronological age; performance was commensurate with a typically developing group matched for non-verbal ability. In contrast, categorisation was typical in WS, although there was some evidence that sensitivity to the size of perceptual colour differences was reduced in this group. Copyright © 2013 Elsevier Ltd. All rights reserved.
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Greer, Chris; McLaughlin, Eugene
2012-01-01
Este artigo analisa a natureza em mudança das relações entre os meios de comunicação social e a chefia da polícia. Com base em estudos prévios (Greer & McLaughlin, 2010), usamos os conceitos de «estrutura inferencial» (Lang & Lang, 1955 e «hierarquia da credibilidade» (Becker, 1967) para analisar o «julgamento pelos media» do antigo comissário do Serviço da Polícia Metropolitana (MPS), Sir Ian Blair. Centramo-nos na reação coletiva e fundamentalmente hostil por parte dos media à declaração de...
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Greer, C.; McLaughlin, E.
2012-01-01
Este artigo analisa a natureza em mudança das relações entre os meios de comunicação social e a chefia da polícia. Com base em estudos prévios (Greer & McLaughlin, 2010), usamos os conceitos de «estrutura inferencial» (Lang & Lang, 1955) e «hierarquia da credibilidade» (Becker, 1967) para analisar o «julgamento pelos media» do antigo comissário do Serviço da Polícia Metropolitana (MPS), Sir Ian Blair. Centramo-nos na reação coletiva e fundamentalmente hostil por parte dos media à declaração d...
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The world in eighteen lessons: Christopher Williams
Berrebi, S.
2011-01-01
Conceptual photographer Christopher Williams is a real artist's artist. Ever since he moved to Germany, his measured work, which both reveres and examines the art of photography, has more and more easily found its way into European art institutes, such as this spring at Museum Dhondt-Dhaenens in
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Analysis of Speech Fluency in Williams Syndrome
Rossi, Natalia Freitas; Sampaio, Adriana; Goncalves, Oscar F.; Giacheti, Celia Maria
2011-01-01
Williams syndrome (WS) is a neurodevelopmental genetic disorder, often referred as being characterized by dissociation between verbal and non-verbal abilities, although the number of studies disputing this proposal is emerging. Indeed, although they have been traditionally reported as displaying increased speech fluency, this topic has not been…
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Attribution of Negative Intention in Williams Syndrome
Godbee, Kali; Porter, Melanie A.
2013-01-01
People with Williams syndrome (WS) are said to have sociable and extremely trusting personalities, approaching strangers without hesitation. This study investigated whether people with WS are less likely than controls to attribute negative intent to others when interpreting a series of ambiguous pictures. This may, at least partially, explain…
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New approaches to improve a WCDMA SIR estimator by employing different post-processing stages
Directory of Open Access Journals (Sweden)
Amnart Chaichoet
2008-09-01
Full Text Available For effective control of transmission power in WCDMA mobile systems, a good estimate of signal-to-interference ratio (SIR is needed. Conventionally, an adaptive SIR estimator employs a moving average (MA filter (Yoon et al., 2002 to encounter fading channel distortion. However, the resulting estimate seems to have high estimation error due to fluctuation in the channel variation. In this paper, an additional post-processing stage is proposed to improve the estimation accuracy by reducing the variation of the estimate. Four variations of post-processing stages, namely 1 a moving average (MA postfilter,2 an exponential moving average (EMA post-filter, 3 an IIR post-filter and 4 least-mean-squared (LMS adaptive post-filter, are proposed and their optimal performance in terms of root-mean-square error (RMSE are then compared by simulation. The results show the best comparable performance when the MA and LMS post-filter are used. However, the MA post-filter requires a lookup table of filter order for optimal performance at different channel conditions, while the LMS post-filter can be used conveniently without a lookup table.
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William Barlow and the Determination of Atomic Arrangement in Crystals.
Mauskopf, Seymour H
2015-04-01
William Barlow (1845-1934) was an important if unconventional scientist, known for having developed the 'closest-packing' atomic models of crystal structure. He resumed an early nineteenth-century tradition of utilizing crystallographical and chemical data to determine atomic arrangements in crystals. This essay recounts Barlow's career and scientific activity in three parts: (a) His place in the tradition of determining atomic arrangement in context of this earlier tradition and of contemporaneous developments of crystallography and chemistry, (b) his unconventional career, and (c) the 'success' of his program to determine atomic arrangements in crystals and its influence on the work of William Lawrence Bragg.
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Design of power controller in CDMA system with power and SIR error minimization
Institute of Scientific and Technical Information of China (English)
Shulan KONG; Huanshui ZHANG; Zhaosheng ZHANG; Hongxia WANG
2007-01-01
In this paper, an uplink power control problem is considered for code division multiple access (CDMA) systems. A distributed algorithm is proposed based on linear quadratic optimal control theory. The proposed scheme minimizes the sum of the power and the error of signal-to-interference ratio (SIR). A power controller is designed by constructing an optimization problem of a stochastic linear quadratic type in Krein space and solving a Kalman filter problem.
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77 FR 63308 - J. William Foley Incorporated v. United Illuminating Company; Notice of Complaint
2012-10-16
... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL12-106-000] J. William Foley Incorporated v. United Illuminating Company; Notice of Complaint Take notice that on October 5...) and 825(e), J. William Foley Incorporated (Complainant) filed a formal complaint against United...
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Crystal clear the autobiographies of Sir Lawrence and Lady Bragg
Thomson, Patience
2015-01-01
The main body of this book contains the hitherto unpublished autobiographies of both William Lawrence Bragg, an innovative scientist who won the Nobel Prize for Physics in 1915, and his wife, Alice, a Mayor of Cambridge and National Chairman of Marriage Guidance. Their autobiographies give unusual insights into the lives and times of two distinguished people and the real personalities behind their public appearance.
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Directory of Open Access Journals (Sweden)
Howard A. Gaberson
1995-01-01
Full Text Available This article discusses time frequency analysis of machinery diagnostic vibration signals. The short time Fourier transform, the Wigner, and the Choi–Williams distributions are explained and illustrated with test cases. Examples of Choi—Williams analyses of machinery vibration signals are presented. The analyses detect discontinuities in the signals and their timing, amplitude and frequency modulation, and the presence of different components in a vibration signal.
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Nutritional support of the hospitalized patIent
African Journals Online (AJOL)
1983-04-16
Apr 16, 1983 ... one ofthe earliest attempts known was that of Sir Christopher. \\\\hen, to whom 50 much ofthe architectural elegance of London can be attributed, being ..... O'Keefe SJO, Abraham R, EI-Zayadi A, Marshall W, O"'is M, Williams R. Increased plasma tyrosine concentrations in patients with cirrhosis and fulmi-.
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Gombos, Ferenc; Bódizs, Róbert; Kovács, Ilona
2017-07-21
Williams syndrome (7q11.23 microdeletion) is characterized by specific alterations in neurocognitive architecture and functioning, as well as disordered sleep. Here we analyze the region, sleep state and frequency-specific EEG synchronization of whole night sleep recordings of 21 Williams syndrome and 21 typically developing age- and gender-matched subjects by calculating weighted phase lag indexes. We found broadband increases in inter- and intrahemispheric neural connectivity for both NREM and REM sleep EEG of Williams syndrome subjects. These effects consisted of increased theta, high sigma, and beta/low gamma synchronization, whereas alpha synchronization was characterized by a peculiar Williams syndrome-specific decrease during NREM states (intra- and interhemispheric centro-temporal) and REM phases of sleep (occipital intra-area synchronization). We also found a decrease in short range, occipital connectivity of NREM sleep EEG theta activity. The striking increased overall synchronization of sleep EEG in Williams syndrome subjects is consistent with the recently reported increase in synaptic and dendritic density in stem-cell based Williams syndrome models, whereas decreased alpha and occipital connectivity might reflect and underpin the altered microarchitecture of primary visual cortex and disordered visuospatial functioning of Williams syndrome subjects.
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Directory of Open Access Journals (Sweden)
Paulo Sérgio Souza Junior
2009-12-01
Full Text Available O presente artigo versa sobre uma síndrome em particular chamada Síndrome de Williams-Beuren. Esta síndrome possui uma relação específica com a música, relação esta que estará no fulcro de nossas preocupações durante as páginas que se seguem. Num primeiro momento faremos uma apresentação da síndrome e de suas singularidades; em seguida nos debruçaremos sobre a especificidade que aqui está em questão, ou seja, a relação da síndrome com o universo sonoro; por fim, traremos um caso com o qual tivemos contato envolvendo a educação musical em contexto da síndrome, e discutiremos a respeito dos elementos que esse contato nos trouxe para pensar essa curiosa e relevante relação entre arte-educação e o desenvolvimento neuropsicológico atípico. The present article is about a particular syndrome, called Williams-Beuren. This syndrome has a very specific relationship with music, which will be at the heart of our concerns over the following pages. Initially we will make a presentation of the syndrome and its singularities. Then we will focus on the uniqueness of the correlation between Williams-Beuren and the musical world. Finally, we will discuss a case which involves musical education in the context of this syndrome, and discuss about the elements, brought by that contact, that are useful to think about this curious and relevant relationship between art education and atypical neuropsychological development.
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2012-09-24
... DEPARTMENT OF EDUCATION Notice of Submission for OMB Review; Federal Student Aid; William D. Ford... William D. Ford Federal Direct Loan Program will use this form to request forbearance on their loans when... of Collection: William D. Ford Federal Direct Loan Program General Forbearance Request. OMB Control...
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2012-05-21
... DEPARTMENT OF EDUCATION Notice of Submission for OMB Review; Federal Student Aid; William D. Ford... borrowers in the William D. Ford Federal Direct Loan (Direct Loan) and Federal Family Education Loan (FFEL... of Collection: William D. Ford Federal Direct Loan Program Deferment Request Forms. OMB Control...
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International Nuclear Information System (INIS)
Bogdanović, Xenia; Hesseler, Martin; Palm, Gottfried J.; Bornscheuer, Uwe T.; Hinrichs, Winfried
2010-01-01
The crystallization and preliminary X-ray diffraction studies of DppA from P. pacifica SIR-I are reported. DppA from Plesiocystis pacifica SIR-I is a putative haloalkane dehalogenase (EC 3.8.1.5) and probably catalyzes the conversion of halogenated alkanes to the corresponding alcohols. The enzyme was expressed in Escherichia coli BL21 and purified to homogeneity by ammonium sulfate precipitation and reversed-phase and ion-exchange chromatography. The DppA protein was crystallized by the vapour-diffusion method and protein crystals suitable for data collection were obtained in the orthorhombic space group P2 1 2 1 2. The DppA crystal diffracted X-rays to 1.9 Å resolution using an in-house X-ray generator
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Clinical utility of an array comparative genomic hybridization analysis for Williams syndrome.
Yagihashi, Tatsuhiko; Torii, Chiharu; Takahashi, Reiko; Omori, Mikimasa; Kosaki, Rika; Yoshihashi, Hiroshi; Ihara, Masahiro; Minagawa-Kawai, Yasuyo; Yamamoto, Junichi; Takahashi, Takao; Kosaki, Kenjiro
2014-11-01
To reveal the relation between intellectual disability and the deleted intervals in Williams syndrome, we performed an array comparative genomic hybridization analysis and standardized developmental testing for 11 patients diagnosed as having Williams syndrome based on fluorescent in situ hybridization testing. One patient had a large 4.2-Mb deletion spanning distally beyond the common 1.5-Mb intervals observed in 10/11 patients. We formulated a linear equation describing the developmental age of the 10 patients with the common deletion; the developmental age of the patient with the 4.2-Mb deletion was significantly below the expectation (developmental age = 0.51 × chronological age). The large deletion may account for the severe intellectual disability; therefore, the use of array comparative genomic hybridization may provide practical information regarding individuals with Williams syndrome. © 2014 Japanese Teratology Society.
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Shepard Award Winners, Part 2: Dr. Tracie Williams
Centers for Disease Control (CDC) Podcasts
2009-07-29
This podcast highlights the accomplishments of Dr. Tracie Williams, recipient of the prestigious 2009 CDC Charles C. Shepard Award. Created: 7/29/2009 by Centers for Disease Control and Prevention (CDC). Date Released: 7/29/2009.
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Vandeweyer, Geert; Van der Aa, Nathalie; Reyniers, Edwin; Kooy, R Frank
2012-06-08
Williams-Beuren syndrome is a rare contiguous gene syndrome, characterized by intellectual disability, facial dysmorphisms, connective-tissue abnormalities, cardiac defects, structural brain abnormalities, and transient infantile hypercalcemia. Genes lying telomeric to RFC2, including CLIP2, GTF2I and GTF2IRD1, are currently thought to be the most likely major contributors to the typical Williams syndrome cognitive profile, characterized by a better-than-expected auditory rote-memory ability, a relative sparing of language capabilities, and a severe visual-spatial constructive impairment. Atypical deletions in the region have helped to establish genotype-phenotype correlations. So far, however, hardly any deletions affecting only a single gene in the disease region have been described. We present here two healthy siblings with a pure, hemizygous deletion of CLIP2. A putative role in the cognitive and behavioral abnormalities seen in Williams-Beuren patients has been suggested for this gene on the basis of observations in a knock-out mouse model. The presented siblings did not show any of the clinical features associated with the syndrome. Cognitive testing showed an average IQ for both and no indication of the Williams syndrome cognitive profile. This shows that CLIP2 haploinsufficiency by itself does not lead to the physical or cognitive characteristics of the Williams-Beuren syndrome, nor does it lead to the Williams syndrome cognitive profile. Although contribution of CLIP2 to the phenotype cannot be excluded when it is deleted in combination with other genes, our results support the hypothesis that GTF2IRD1 and GTF2I are the main genes causing the cognitive defects associated with Williams-Beuren syndrome. Copyright © 2012 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.
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Maximilien Brice; CMS
2009-01-01
Ian Taylor MBE MP Chairman Parliamentary and Scientific Committee, United Kingdom (second from left) with (from left to right) CMS Technical Coordinator A. Ball, CMS Spokesperson Tejinder (Jim) Virdee and Adviser to the Director-General J. Ellis on 2 November 2009.
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Leonard, Hayley C.; Annaz, Dagmara; Karmiloff-Smith, Annette; Johnson, Mark H.
2011-01-01
The current study investigated whether contrasting face recognition abilities in autism and Williams syndrome could be explained by different spatial frequency biases over developmental time. Typically-developing children and groups with Williams syndrome and autism were asked to recognise faces in which low, middle and high spatial frequency…
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Denigrating Carl Rogers: William Coulson's Last Crusade.
Kirschenbaum, Howard
1991-01-01
Reviews William Coulson's assertions that Carl Rogers, Abraham Maslow, and he initiated the humanistic education field, that Rogers repudiated his philosophy late in life, and that they owe the nation's parents an apology. Argues that these charges are groundless and provides examples and quotations from Rogers' later writings to show how Rogers…
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Fears, Hyperacusis and Musicality in Williams Syndrome
Blomberg, Stefan; Rosander, Michael; Andersson, Gerhard
2006-01-01
The study investigated the prevalence of fear and hyperacusis and the possible connections between fear, hyperacusis and musicality in a Swedish sample of individuals with Williams syndrome (WS). The study included 38 individuals and a cross-sectional design, with no matched control group. Two persons, who knew the participant well, completed a…
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Executive Functions in Individuals with Williams Syndrome
Menghini, D.; Addona, F.; Costanzo, F.; Vicari, S.
2010-01-01
Background: The present study was aimed at investigating working memory (WM) and executive functions capacities in individuals with Williams syndrome (WS) as compared with mental-age matched typically developing (TD) children. Method: In order to serve the study goal, a sizeable battery of tasks tapping WM as well as attention, memory, planning,…
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Directory of Open Access Journals (Sweden)
Paula Yurss Lasanta
2017-12-01
Full Text Available British author Helen Maria Williams (1759-1827 was a well-known figure in the eighteenth century literary circles, whose work was praised by Elizabeth Montagu, Samuel Johnson, Dorothy and William Wordsworth, Mary Wollstonecraft, Hester Piozzi or Alexander von Humboldt. In her early poems Edwin and Eltruda (1782, An Ode to the Peace (1783 and Peru (1784, Williams starts to reveal her political tendencies by appealing to strong empathic feelings as a key to social and political transformation. As a result of her interest in politics, she travelled to France in 1790 and published her most acclaimed work Letters from France (1790. However, the rest of her production has received little critical attention by modern scholars, who have overlooked her involvement in translation. Williams’ only extant novel, Julia (1790 is in fact a creative translation of Rousseau’s Julie ou La Nouvelle Héloïse (1761, in which Williams includes poems that evidence her interest in revolutionary politics. Four years later, she translated Bernardin de Saint Pierre’s Paul et Virginie, while she was imprisoned in Paris. While translating novels was regarded as a respectable exercise for women writers, Williams challenges gender assumptions by translating Researches (1814 and the seven volumes of Personal Narrative (1814-1829, which had been produced by one of the most influential eighteenth century scientists, Alexander von Humboldt. This article interrogates how Williams makes use of translation to access areas of knowledge traditionally restricted to men, such as philosophy, politics and science. For this purpose, I will focus on her translations of the work of two leading intellectual figures of the eighteenth century, Rousseau and Von Humboldt.
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Läbi legendide William Shakespeare'i poole / Maris Peters
Peters, Maris
2010-01-01
Tutvustus: Wells, Stanley. Kas on tõsi, et Shakespeare ...? / tõlkinud Maris Peters. Tallinn : Argo, 2010. Raamat William Shakespeare kohta käivatest legendidest, kuuldustest ja teooriatest ning tema teoste autorsusest
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William and Caroline Herschel pioneers in late 18th-century astronomy
Hoskin, Michael
2013-01-01
This beautifully structured book presents the essentials of William and Caroline Herschel's pioneering achievements in late 18th-century astronomy. Michael Hoskin shows that William Herschel was the first observational cosmologist and one of the first observers to attack the sidereal universe beyond the solar system:Herschel built instruments far better than any being used at the royal observatory. Aided by his sister Caroline, he commenced a great systematic survey that led to his discovery of Uranus in 1781.Unlike observers before him, whose telescopes did not reveal them as astronomical obj
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Kes on kes ehk Tulgu uus taevas / Ervin Õunapuu
Õunapuu, Ervin, 1956-
2002-01-01
Tuntud tegijad, kes on oma sõnul ateistid, agnostikud või umbuskliku suhtumisega ristiusu kirikusse: William Seward Burroughs, Vincent Van Gogh, Oscar Niemeyer, Sven Alur Reinans, Sir Joshua Reynolds, Diego Rivera, Neil Rogers, John Ruskin, Matt Wagner, Frank Lloyd Wright, Ervin Õunapuu jne. Ilmunud ka kogumikus "Öövöö", lk.109-124
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Thermal vacuum test of space equipment: tests of SIR-2 instrument Chandrayaan-1 mission
Sitek, P.
2008-11-01
We describe the reasons of proceeding Thermal-Vacuum tests for space electronic. We will answer on following questions: why teams are doing TV tests, what kind of phases should be simulated, which situations are the most critical during TV tests, what kind of results should be expected, which errors can be detect. As an example, will be shown TV-test of SIR-2 instrument for Chandrayaan-1 moon mission.
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Herbert Hoover and William Shakespeare: Two Writers on Ethics.
Somers, Margaret L.
1979-01-01
Outlines the ways in which Herbert Hoover and William Shakespeare wrote about professional ethics (for engineers and kings, respectively) using the writing techniques of concreteness, audience awareness, and development by induction. (TJ)
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2013-07-29
... DEPARTMENT OF EDUCATION [Docket No.: ED-2013-ICCD-0099] Agency Information Collection Activities; Comment Request; William D. Ford Federal Direct Loan Program Repayment Plan Selection Form AGENCY... notice will be considered public records. Title of Collection: William D. Ford Federal Direct Loan...
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Psycholinguistic Abilities of Children with Williams Syndrome
Rossi, Natalia F.; Heinze, Elena Garayzabal; Giacheti, Celia M.; Goncalves, Oscar F.; Sampaio, Adriana
2012-01-01
The objective of this study was to investigate the psycholinguistic abilities of children with Williams syndrome (WS) and typically developing children using the Illinois Test of Psycholinguistic Abilities (ITPA). Performance on the ITPA was analysed in a group with WS (N=20, mean age=8.5 years, SD=1.62) and two typically developing groups,…
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2013-08-22
... DEPARTMENT OF EDUCATION [Docket No. ED-2013-ICCD-0109] Agency Information Collection Activities; Comment Request; William D. Ford Federal Direct Loan (Direct Loan) Program Federal Direct PLUS Loan Master... to this notice will be considered public records. Title of Collection: William D. Ford Federal Direct...
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Crespi, Bernard J; Procyshyn, Tanya L
2017-08-01
We describe and evaluate an integrative hypothesis for helping to explain the major neurocognitive features of individuals with Williams syndrome region deletions and duplications. First, we demonstrate how the cognitive differences between Williams syndrome individuals, individuals with duplications of this region, and healthy individuals parallel the differences between individuals subject to effects of increased or decreased oxytocin. Second, we synthesize evidence showing that variation in expression of the gene GTF2I (General Transcription Factor II-I) underlies the primary social phenotypes of Williams syndrome and that common genetic variation in GTF2I mediates oxytocin reactivity, and its correlates, in healthy populations. Third, we describe findings relevant to the hypothesis that the GTF2I gene is subject to parent of origin effects whose behavioral expression fits with predictions from the kinship theory of genomic imprinting. Fourth, we describe how Williams syndrome can be considered, in part, as an autistic syndrome of Lorna Wing's 'active-but-odd' autism subtype, in contrast to associations of duplications with both schizophrenia and autism. Copyright © 2017 Elsevier Ltd. All rights reserved.
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Williams syndrome and mature B-Leukemia: A random association?
Decimi, Valentina; Fazio, Grazia; Dell'Acqua, Fabiola; Maitz, Silvia; Galbiati, Marta; Rizzari, Carmelo; Biondi, Andrea; Cazzaniga, Giovanni; Selicorni, Angelo
2016-12-01
Williams syndrome (WBS) is a rare neurodevelopmental disorder with specific phenotypic characteristics and cardiac abnormalities, but is not considered as a cancer predisposing condition. However, in rare cases, malignancies have been described in patients with WBS, with hematologic cancer (mainly Burkitt Lymphoma and Acute Lymphoblastic Leukemia) as the most represented. We report here the case of a boy with WS and B-NHL. This is the unique case within the large cohort of patients (n = 117) followed in our institution for long time (mean clinical follow-up, 13 years). We herewith propose that the BCL7B gene, located in the chromosomal region commonly deleted in Williams syndrome, could potentially have a role in this particular association. Copyright © 2016 Elsevier Masson SAS. All rights reserved.
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Ischemic Stroke in Williams-Beuren Syndrome: A Case Report
Directory of Open Access Journals (Sweden)
Wei-Der Lee
2009-04-01
Full Text Available A 15-year-old girl was admitted because of an acute onset of facial palsy and right hemiparesis. The patient had a history of moderate mental retardation and developmental delay. On admission, her vital signs were stable, except for high blood pressure. Magnetic resonance imaging demonstrated an infarct involving the left internal capsule and putamen. Because of the patient's young age, an extensive stroke survey was performed. Williams-Beuren syndrome was finally confirmed by fluorescent in situ hybridization. Compared with the previously reported cases, no evidence of cerebral arterial stenosis or cardiac abnormalities was found by noninvasive imaging techniques. Because Williams-Beuren syndrome is a complex, multiple congenital anomaly syndrome with prominent cardiovascular features, regular assessment and antihypertensive treatment are necessary to minimize the lifelong cardiovascular risk in patients with this syndrome.
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Sawtooth events and O+ in the plasma sheet and boundary layer: CME- and SIR-driven events
Lund, E. J.; Nowrouzi, N.; Kistler, L. M.; Cai, X.; Liao, J.
2017-12-01
The role of ionospheric ions in sawtooth events is an open question. Simulations[1,2,3] suggest that O+ from the ionosphere produces a feedback mechanism for driving sawtooth events. However, observational evidence[4,5] suggest that the presence of O+ in the plasma sheet is neither necessary nor sufficient. In this study we investigate whether the solar wind driver of the geomagnetic storm has an effect on the result. Building on an earlier study[4] that used events for which Cluster data is available in the plasma sheet and boundary layer, we perform a superposed epoch analysis for coronal mass ejection (CME) driven storms and streaming interaction region (SIR) driven storms separately, to investigate the hypothesis that ionospheric O+ is an important contributor for CME-driven storms but not SIR-driven storms[2]. [1]O. J. Brambles et al. (2011), Science 332, 1183.[2]O. J. Brambles et al. (2013), JGR 118, 6026.[3]R. H. Varney et al. (2016), JGR 121, 9688.[4]J. Liao et al. (2014), JGR 119, 1572.[5]E. J. Lund et al. (2017), JGR, submitted.
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Dynamical Analysis of SIR Epidemic Models with Distributed Delay
Directory of Open Access Journals (Sweden)
Wencai Zhao
2013-01-01
Full Text Available SIR epidemic models with distributed delay are proposed. Firstly, the dynamical behaviors of the model without vaccination are studied. Using the Jacobian matrix, the stability of the equilibrium points of the system without vaccination is analyzed. The basic reproduction number R is got. In order to study the important role of vaccination to prevent diseases, the model with distributed delay under impulsive vaccination is formulated. And the sufficient conditions of globally asymptotic stability of “infection-free” periodic solution and the permanence of the model are obtained by using Floquet’s theorem, small-amplitude perturbation skills, and comparison theorem. Lastly, numerical simulation is presented to illustrate our main conclusions that vaccination has significant effects on the dynamical behaviors of the model. The results can provide effective tactic basis for the practical infectious disease prevention.
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Experiences of Bullying for Individuals with Williams Syndrome
Fisher, Marisa H.; Lough, Emma; Griffin, Megan M.; Lane, Laurel A.
2017-01-01
Background: Individuals with intellectual disability experience high rates of bullying, but it is not known how people with specific syndromes, such as Williams syndrome (WS), experience and respond to bullying. Given their behavioral profile, including hypersociability and heightened anxiety, and their risk for experiencing other forms of…
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McILwain, R Britt; Timpa, Joseph G; Kurundkar, Ashish R; Holt, David W; Kelly, David R; Hartman, Yolanda E; Neel, Mary Lauren; Karnatak, Rajendra K; Schelonka, Robert L; Anantharamaiah, G M; Killingsworth, Cheryl R; Maheshwari, Akhil
2010-01-01
Extracorporeal membrane oxygenation (ECMO) is a life-saving support system used in neonates and young children with severe cardiorespiratory failure. Although ECMO has reduced mortality in these critically ill patients, almost all patients treated with ECMO develop a systemic inflammatory response syndrome (SIRS) characterized by a 'cytokine storm', leukocyte activation, and multisystem organ dysfunction. We used a neonatal porcine model of ECMO to investigate whether rising plasma concentrations of inflammatory cytokines during ECMO reflect de novo synthesis of these mediators in inflamed tissues, and therefore, can be used to assess the severity of ECMO-related SIRS. Previously healthy piglets (3-week-old) were subjected to venoarterial ECMO for up to 8 h. SIRS was assessed by histopathological analysis, measurement of neutrophil activation (flow cytometry), plasma cytokine concentrations (enzyme immunoassays), and tissue expression of inflammatory genes (PCR/western blots). Mast cell degranulation was investigated by measurement of plasma tryptase activity. Porcine neonatal ECMO was associated with systemic inflammatory changes similar to those seen in human neonates. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) concentrations rose rapidly during the first 2 h of ECMO, faster than the tissue expression of these cytokines. ECMO was associated with increased plasma mast cell tryptase activity, indicating that increased plasma concentrations of inflammatory cytokines during ECMO may result from mast cell degranulation and associated release of preformed cytokines stored in mast cells. TNF-alpha and IL-8 concentrations rose faster in plasma than in the peripheral tissues during ECMO, indicating that rising plasma levels of these cytokines immediately after the initiation of ECMO may not reflect increasing tissue synthesis of these cytokines. Mobilization of preformed cellular stores of inflammatory cytokines such as in mucosal mast cells may have
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Fung, Lawrence K; Quintin, Eve-Marie; Haas, Brian W; Reiss, Allan L
2012-04-01
The overarching goal of this review is to compare and contrast the cognitive-behavioral features of fragile X syndrome (FraX) and Williams syndrome and to review the putative neural and molecular underpinnings of these features. Information is presented in a framework that provides guiding principles for conceptualizing gene-brain-behavior associations in neurodevelopmental disorders. Abnormalities, in particular cognitive-behavioral domains with similarities in underlying neurodevelopmental correlates, occur in both FraX and Williams syndrome including aberrant frontostriatal pathways leading to executive function deficits, and magnocellular/dorsal visual stream, superior parietal lobe, inferior parietal lobe, and postcentral gyrus abnormalities contributing to deficits in visuospatial function. Compelling cognitive-behavioral and neurodevelopmental contrasts also exist in these two disorders, for example, aberrant amygdala and fusiform cortex structure and function occurring in the context of contrasting social behavioral phenotypes, and temporal cortical and cerebellar abnormalities potentially underlying differences in language function. Abnormal dendritic development is a shared neurodevelopmental morphologic feature between FraX and Williams syndrome. Commonalities in molecular machinery and processes across FraX and Williams syndrome occur as well - microRNAs involved in translational regulation of major synaptic proteins; scaffolding proteins in excitatory synapses; and proteins involved in axonal development. Although the genetic variations leading to FraX and Williams syndrome are different, important similarities and contrasts in the phenotype, neurocircuitry, molecular machinery, and cellular processes in these two disorders allow for a unique approach to conceptualizing gene-brain-behavior links occurring in neurodevelopmental disorders.
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Analysis of Active Lava Flows on Kilauea Volcano, Hawaii, Using SIR-C Radar Correlation Measurements
Zebker, H. A.; Rosen, P.; Hensley, S.; Mouginis-Mark, P. J.
1995-01-01
Precise eruption rates of active pahoehoe lava flows on Kilauea volcano, Hawaii, have been determined using spaceborne radar data acquired by the Space Shuttle Imaging Radar-C (SIR-C). Measurement of the rate of lava flow advance, and the determination of the volume of new material erupted in a given period of time, are among the most important observations that can be made when studying a volcano.
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Rodgers, Jacqui; Riby, Deborah M.; Janes, Emily; Connolly, Brenda; McConachie, Helen
2012-01-01
Children with Autism Spectrum Disorder or Williams syndrome are vulnerable to anxiety. The factors that contribute to this risk remain unclear. This study compared anxiety in autism spectrum disorder and Williams Syndrome and examined the relationship between repetitive behaviours and anxiety. Thirty-four children with autism and twenty children…
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Electrophysiological Correlates of Semantic Processing in Williams Syndrome
Pinheiro, Ana P.; Galdo-Alvarez, Santaigo; Sampaio, Adriana; Niznikiewicz, Margaret; Goncalves, Oscar F.
2010-01-01
Williams syndrome (WS), a genetic neurodevelopmental disorder due to microdeletion in chromosome 7, has been described as a syndrome with an intriguing socio-cognitive phenotype. Cognitively, the relative preservation of language and face processing abilities coexists with severe deficits in visual-spatial tasks, as well as in tasks involving…
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Bheda, Poonam; Swatkoski, Stephen; Fiedler, Katherine L; Boeke, Jef D; Cotter, Robert J; Wolberger, Cynthia
2012-04-17
Although the biological roles of many members of the sirtuin family of lysine deacetylases have been well characterized, a broader understanding of their role in biology is limited by the challenges in identifying new substrates. We present here an in vitro method that combines biotinylation and mass spectrometry (MS) to identify substrates deacetylated by sirtuins. The method permits labeling of deacetylated residues with amine-reactive biotin on the ε-nitrogen of lysine. The biotin can be utilized to purify the substrate and identify the deacetylated lysine by MS. The biotinyl-lysine method was used to compare deacetylation of chemically acetylated histones by the yeast sirtuins, Sir2 and Hst2. Intriguingly, Sir2 preferentially deacetylates histone H3 lysine 79 as compared to Hst2. Although acetylation of K79 was not previously reported in Saccharomyces cerevisiae, we demonstrate that a minor population of this residue is indeed acetylated in vivo and show that Sir2, and not Hst2, regulates the acetylation state of H3 lysine 79. The in vitro biotinyl-lysine method combined with chemical acetylation made it possible to identify this previously unknown, low-abundance histone acetyl modification in vivo. This method has further potential to identify novel sirtuin deacetylation substrates in whole cell extracts, enabling large-scale screens for new deacetylase substrates.
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Krinsky-McHale, Sharon J.; Kittler, Phyllis; Brown, W. Ted; Jenkins, Edmund C.; Devenny, Darlynne A.
2005-01-01
We examined implicit and explicit memory in adults with Williams syndrome. An age-related dissociation was found; repetition priming (reflecting implicit memory) did not show change with age, but free recall (reflecting explicit memory) was markedly reduced. We also compared the performance of adults with Williams syndrome to adults with Down…
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British energy policy and the market for coal - minutes of evidence - Tuesday 1 December 1992
Energy Technology Data Exchange (ETDEWEB)
1992-12-01
The Committee set up to examine UK energy policy and the market for coal (particularly British Coal's place in that market), examined evidence from: Mr David Porter, Mr Neil Bryson, Mr Fergus Wiggin and Mr John Macadam (Association of Independent Electricity Producers); Mr John Collins, Mr John Wybrew, Dr Chris Fay and Mr Ian Wybrew-Bond (Shell UK Ltd); Sir James McKinnon and Mr Greg McGregor (Office of Gas Supply (OFGAS)). Aspects covered include consequences of British Coal's pit closure programme, UK natural gas reserves, and the effects of increased demand for natural gas due to the 'dash for gas' (i.e. generating electricity from natural gas rather than coal).
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Kozel, Beth A; Danback, Joshua R; Waxler, Jessica L; Knutsen, Russell H; de Las Fuentes, Lisa; Reusz, Gyorgy S; Kis, Eva; Bhatt, Ami B; Pober, Barbara R
2014-01-01
Williams syndrome is caused by the deletion of 26 to 28 genes, including elastin, on human chromosome 7. Elastin insufficiency leads to the cardiovascular hallmarks of this condition, namely focal stenosis and hypertension. Extrapolation from the Eln(+/-) mouse suggests that affected people may also have stiff vasculature, a risk factor for stroke, myocardial infarction, and cardiac death. NCF1, one of the variably deleted Williams genes, is a component of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex and is involved in the generation of oxidative stress, making it an interesting candidate modifier for vascular stiffness. Using a case-control design, vascular stiffness was evaluated by pulse wave velocity in 77 Williams cases and matched controls. Cases had stiffer conducting vessels than controls (PWilliams syndrome. Pulse wave velocity increased with age at comparable rates in cases and controls, and although the degree of vascular stiffness varied, it was seen in both hypertensive and normotensive Williams participants. Use of antihypertensive medication and extension of the Williams deletion to include NCF1 were associated with protection from vascular stiffness. These findings demonstrate that vascular stiffness is a primary vascular phenotype in Williams syndrome and that treatment with antihypertensives or agents inhibiting oxidative stress may be important in managing patients with this condition, potentially even those who are not overtly hypertensive.
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Adaptive Functioning in Williams Syndrome: A Systematic Review
Brawn, Gabrielle; Porter, Melanie
2018-01-01
Literature on the level of adaptive functioning and relative strengths and weaknesses in functioning of individuals with Williams syndrome (WS) was reviewed. The electronic databases PsycINFO, PubMed, Expanded Academic, Web of Science, Scopus and ProQuest were searched electronically for relevant articles and dissertations using the search terms…
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Potential Beneficial Effects of Tulbaghia violacea William Henry ...
African Journals Online (AJOL)
Tulbaghia violacea William Henry Harvey (Harv. Alliaceae) is a small bulbous herb belonging to the family Alliaceae. It is used in South Africa to treat fever, colds, asthma, paralysis, and hypertension. Meanwhile, cardiovascular disease accounts for about 30 % of total global death, with most of these deaths occurring in low ...
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2012-09-24
... DEPARTMENT OF EDUCATION Notice of Proposed Information Collection Requests; Federal Student Aid; William D. Ford Federal Direct Loan Program Regulations-- Servicemembers Civil Relief Act SUMMARY: Upon a... in response to this notice will be considered public records. Title of Collection: William D. Ford...
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Estrutura e significado em "Uma rosa para Emily", de William Faulkner
Directory of Open Access Journals (Sweden)
Carlos Daghlian
2004-01-01
Full Text Available Trata-se de uma análise do consagrado conto "Uma Rosa para Emily", de William Faulkner, voltada para alguns dos principais aspectos de sua estrutura. Após considerarmos o enredo, discutimos a construção das personagens, com destaque para a protagonista, fazendo um levantamento e comentários sobre possíveis fontes de inspiração, destacando, entre outras, aspectos da biografia da poeta Emily Dickinson, a ficção e a poesia de E. A. Poe, romances de Charles Dickens e Henry James, o conto de Sherwood Anderson e a poesia de William Blake, Emily Dickinson, Robert Browning e John Crowe Ransom, acrescentando paralelos com o conto "Bartleby, o escrivão", de Herman Melville. Analisamos, então, o foco narrativo, os símbolos e o significado, ressaltando aqui o desenvolvimento temático da narrativa.This is an analysis of the well-known short story "A Rose for Emily," by William Faulkner, concentrating on some of the main aspects of its structure. A consideration of the plot is followed by a discussion of characterization, with emphasis on the protagonist, by means of a survey and comments on possible sources of inspiration including, among others, aspects of Emily Dickinson's biography, E. A. Poe's fiction and poetry, novels by Charles Dickens and Henry James, Sherwood Anderson's short stories, and the poetry of William Blake, Emily Dickinson, Robert Browning, and John Crowe Ransom, in addition to Herman Melville's short story "Bartleby, the Scrivener." The narrative focus, symbolism and meaning, stressing the thematic development of the narrative, are then analyzed.
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Bayesian stock assessment of Pacific herring in Prince William Sound, Alaska.
Muradian, Melissa L; Branch, Trevor A; Moffitt, Steven D; Hulson, Peter-John F
2017-01-01
The Pacific herring (Clupea pallasii) population in Prince William Sound, Alaska crashed in 1993 and has yet to recover, affecting food web dynamics in the Sound and impacting Alaskan communities. To help researchers design and implement the most effective monitoring, management, and recovery programs, a Bayesian assessment of Prince William Sound herring was developed by reformulating the current model used by the Alaska Department of Fish and Game. The Bayesian model estimated pre-fishery spawning biomass of herring age-3 and older in 2013 to be a median of 19,410 mt (95% credibility interval 12,150-31,740 mt), with a 54% probability that biomass in 2013 was below the management limit used to regulate fisheries in Prince William Sound. The main advantages of the Bayesian model are that it can more objectively weight different datasets and provide estimates of uncertainty for model parameters and outputs, unlike the weighted sum-of-squares used in the original model. In addition, the revised model could be used to manage herring stocks with a decision rule that considers both stock status and the uncertainty in stock status.
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Bayesian stock assessment of Pacific herring in Prince William Sound, Alaska.
Directory of Open Access Journals (Sweden)
Melissa L Muradian
Full Text Available The Pacific herring (Clupea pallasii population in Prince William Sound, Alaska crashed in 1993 and has yet to recover, affecting food web dynamics in the Sound and impacting Alaskan communities. To help researchers design and implement the most effective monitoring, management, and recovery programs, a Bayesian assessment of Prince William Sound herring was developed by reformulating the current model used by the Alaska Department of Fish and Game. The Bayesian model estimated pre-fishery spawning biomass of herring age-3 and older in 2013 to be a median of 19,410 mt (95% credibility interval 12,150-31,740 mt, with a 54% probability that biomass in 2013 was below the management limit used to regulate fisheries in Prince William Sound. The main advantages of the Bayesian model are that it can more objectively weight different datasets and provide estimates of uncertainty for model parameters and outputs, unlike the weighted sum-of-squares used in the original model. In addition, the revised model could be used to manage herring stocks with a decision rule that considers both stock status and the uncertainty in stock status.
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A stochastic SIRS epidemic model with infectious force under intervention strategies
Cai, Yongli; Kang, Yun; Banerjee, Malay; Wang, Weiming
2015-12-01
In this paper, we extend a classical SIRS epidemic model with the infectious forces under intervention strategies from a deterministic framework to a stochastic differential equation (SDE) one through introducing random fluctuations. The value of our study lies in two aspects. Mathematically, by using the Markov semigroups theory, we prove that the reproduction number R0S can be used to govern the stochastic dynamics of SDE model. If R0S 1, under mild extra conditions, it has an endemic stationary distribution which leads to the stochastical persistence of the disease. Epidemiologically, we find that random fluctuations can suppress disease outbreak, which can provide us some useful control strategies to regulate disease dynamics.
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Sir Charles Bell (1774-1842) and his contributions to early neurosurgery.
Tubbs, R Shane; Riech, Sheryl; Verma, Ketan; Mortazavi, Martin M; Loukas, Marios; Benninger, Brion; Cohen-Gadol, Aaron A
2012-03-01
The renowned surgeon, neuroanatomist, and artist Sir Charles Bell not only impacted the lives of his peers through his creative endeavors and passion for art, but also sparked noteworthy breakthroughs in the field of neuroscience. His empathetic nature and zest for life enabled him to develop an early proclivity for patient care. As a result of his innovative findings regarding sensory and motor nerves and the anatomical makeup of the brain, he accepted some of the most prestigious awards and received an honorable reputation in society. Bell is recognized for his diligence, perseverance, and his remarkable contributions to surgery. The present review will explore his contributions to the discipline now known as neurosurgery.
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Maurice Couturier. Nabokov ou la cruauté du désir.
Directory of Open Access Journals (Sweden)
René Alladaye
2006-04-01
Full Text Available La lecture peut avoir partie liée avec la transgression. Maurice Couturier en apporte la preuve dans son dernier ouvrage, Nabokov ou la cruauté du désir, en enfreignant l’un des plus célèbres interdits nabokoviens, celui de la lecture psychanalytique de son œuvre. On se souvient des préfaces des romans où l’auteur ne se fait jamais faute de décourager la moindre velléité freudienne et d’une réponse des plus tranchantes administrée dans le cadre d’un entretien : « Laissons les crédules et les ...
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Neural Correlates of Amusia in Williams Syndrome
Lense, Miriam D.; Dankner, Nathan; Pryweller, Jennifer R.; Thornton-Wells, Tricia A.; Dykens, Elisabeth M.
2014-01-01
Congenital amusia is defined by marked deficits in pitch perception and production. Though historically examined only in otherwise typically developing (TD) populations, amusia has recently been documented in Williams syndrome (WS), a genetic, neurodevelopmental disorder with a unique auditory phenotype including auditory sensitivities and increased emotional responsiveness to music but variable musical skill. The current study used structural T1-weighted magnetic resonance imaging and diffus...
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2011-03-14
... Furniture Group, Inc., Formerly Known as Falcon Products, Inc., Shelby Williams, Howe and Thonet, Including...., Formerly Known as Falcon Products, Inc., Shelby Williams, Howe and Thonet, Chicago, IL; Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance In accordance with Section 223 of...
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Report of Some Comets: The Discovery of Uranus and Comets by William, Caroline, and John Herschel
Pasachoff, Jay M.; Olson, R. J. M.
2011-01-01
We report on the discovery and drawings of comets by William, Caroline, and John Herschel. The first discovery, by William Herschel, in 1781 from Bath, published in the Philosophical Transactions of the Royal Society with the title "Report of a Comet," turned out to be Uranus, the first planet ever discovered, Mercury through Saturn having been known since antiquity. William's sister Caroline was given duties of sweeping the skies and turned out to be a discoverer of 8 comets in her own right, in addition to keeping William's notes. Caroline's comets were discovered from Slough between 1786 and 1797. In the process, we also discuss original documents from the archives of the Royal Society and of the Royal Astronomical Society. We conclude by showing comet drawings that we have recently attributed to John Herschel, including Halley's Comet from 1836, recently located in the Ransom Center of the University of Texas at Austin. Acknowledgments: Planetary astronomy at Williams College is supported in part by grant NNX08AO50G from NASA Planetary Astronomy. We thank Peter Hingley of the Royal Astronomical Society and Richard Oram of the Harry Ransom Center of The University of Texas at Austin for their assistance.
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Directory of Open Access Journals (Sweden)
Joelle K Salazar
Full Text Available Salmonella enterica is a frequent contaminant of minimally-processed fresh produce linked to major foodborne disease outbreaks. The molecular mechanisms underlying the association of this enteric pathogen with fresh produce remain largely unexplored. In our recent study, we showed that the expression of a putative stress regulatory gene, ycfR, was significantly induced in S. enterica upon exposure to chlorine treatment, a common industrial practice for washing and decontaminating fresh produce during minimal processing. Two additional genes, sirA involved in S. enterica biofilm formation and yigG of unknown function, were also found to be differentially regulated under chlorine stress. To further characterize the roles of ycfR, sirA, and yigG in S. enterica attachment and survival on fresh produce, we constructed in-frame deletions of all three genes in two different S. enterica serovars, Typhimurium and Saintpaul, which have been implicated in previous disease outbreaks linked to fresh produce. Bacterial attachment to glass and polystyrene microtiter plates, cell aggregation and hydrophobicity, chlorine resistance, and surface attachment to intact spinach leaf and grape tomato were compared among wild-type strains, single-gene deletion mutants, and their respective complementation mutants. The results showed that deletions of ycfR, sirA, and yigG reduced bacterial attachment to glass and polystyrene as well as fresh produce surface with or without chlorine treatment in both Typhimurium and Saintpaul. Deletion of ycfR in Typhimurium significantly reduced bacterial chlorine resistance and the attachment to the plant surfaces after chlorinated water washes. Deletions of ycfR in Typhimurium and yigG in Saintpaul resulted in significant increase in cell aggregation. Our findings suggest that ycfR, sirA, and yigG collectively contribute to S. enterica surface attachment and survival during post-harvest minimal processing of fresh produce.
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Ethical Life in Kierkegaard and Williams
Stocker, Barry
2018-01-01
A discussion of how the criticisms of ethical theory in Søren Kierkegaard and Bernard Williams both reinforce each other and also provide some challenges to each other. Despite Williams’ brief and dismissive encounter with Kierkegaard around the reading of a ancient tragedy, both oppose any tendency to see the characters in those tragedies as lacking in agency. Both are consistently concerned with how the individual struggles for some ethical agency and how no individual can be free of the in...
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Garc??a Lara, Antonia
2011-01-01
My dissertation deals with the patriarchal education that indoctrinates women and forces them to be domestic angels and how this education provokes a trauma that they try to heal by creation in the form of writing. I will use two case studies to illustrate my point: Carmen Mart??n Gaite???s C., who is Mart??n Gaite???s alter ego in El Cuarto de Atr??s [The Back Room] (1978), and Briony Tallis, who is a fictional character in Ian McEwan???s Atonement (2001). Briony is actually the one who writ...
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Prince William Sound, Alaska ESI: M_MAMMAL (Marine Mammal Polygons)
National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) data for Prince William Sound, Alaska. ESI data characterize estuarine environments and wildlife by...
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How acquainting shows verbally
DEFF Research Database (Denmark)
Hermann, Jesper
2004-01-01
A central tenet of the integrational view of language and communication is an anchoring in the acting and integrating behaviour of the communicants themselves. In this way the integrational approach has a certain phenomenological slant. What happens when this approach is combined with a ¿psycholo...... to some of William James' classical psychological observations. 16...... of linguistic exertion¿ based upon the descriptions of the stream of thought, and of conception (>acquainting) by William James? Text-examples taken from an internet site for dieters illustrate the combined James'ian & integrational approach in practice. Some of the examples are also specifically related......A central tenet of the integrational view of language and communication is an anchoring in the acting and integrating behaviour of the communicants themselves. In this way the integrational approach has a certain phenomenological slant. What happens when this approach is combined with a ¿psychology...
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Energy Technology Data Exchange (ETDEWEB)
Rothenberg, L. [Memorial Sloan-Kettering Cancer Center (United States)
2015-06-15
Roentgen and the Birth of Modern Medical Physics – Perry Sprawls Wilhelm Roentgen is well known for his discovery of x-radiation. What is less known and appreciated is his intensive research following the discovery to determine the characteristics of the “new kind of radiation” and demonstrate its great value for medical purposes. In this presentation we will imagine ourselves in Roentgen’s mind and follow his thinking, including questions and doubts, as he designs and conducts a series of innovative experiments that provided the foundation for the rapid growth of medical physics. Learning Objectives: Become familiar with the personal characteristics and work of Prof. Roentgen that establishes him as an inspiring model for the medical physics profession. Observe the thought process and experiments that determined and demonstrated the comprehensive characteristics of x-radiation. The AAPM Award Eponyms: William D. Coolidge, Edith H. Quimby, and Marvin M.D. Williams - Who were they and what did they do? – Lawrence N. Rothenberg William David Coolidge (1873–1975) William Coolidge was born in Hudson, NY in 1873. He obtained his BS at the Massacusetts Institute of Technology in 1896. Coolidge then went to the University of Leipzig, Germany for graduate study with physicists Paul Drude and Gustave Wiedemann and received a Ph.D. in 1899. While in Germany he met Wilhelm Roentgen. Coolidge returned to the US to teach at MIT where he was associated with Arthur A. Noyes of the Chemistry Department, working on the electrical conductivity of aqueous solutions. Willis R. Whitney, under whom Coolidge had worked before going to Germany, became head of the newly formed General Electric Research Laboratory and he invited Coolidge to work with him. In 1905, Coolidge joined the staff of the GE laboratory and was associated with it for the remainder of his life. He developed ductile tungsten filaments to replace fragile carbon filaments as the material for electric light
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International Nuclear Information System (INIS)
Rothenberg, L.
2015-01-01
Roentgen and the Birth of Modern Medical Physics – Perry Sprawls Wilhelm Roentgen is well known for his discovery of x-radiation. What is less known and appreciated is his intensive research following the discovery to determine the characteristics of the “new kind of radiation” and demonstrate its great value for medical purposes. In this presentation we will imagine ourselves in Roentgen’s mind and follow his thinking, including questions and doubts, as he designs and conducts a series of innovative experiments that provided the foundation for the rapid growth of medical physics. Learning Objectives: Become familiar with the personal characteristics and work of Prof. Roentgen that establishes him as an inspiring model for the medical physics profession. Observe the thought process and experiments that determined and demonstrated the comprehensive characteristics of x-radiation. The AAPM Award Eponyms: William D. Coolidge, Edith H. Quimby, and Marvin M.D. Williams - Who were they and what did they do? – Lawrence N. Rothenberg William David Coolidge (1873–1975) William Coolidge was born in Hudson, NY in 1873. He obtained his BS at the Massacusetts Institute of Technology in 1896. Coolidge then went to the University of Leipzig, Germany for graduate study with physicists Paul Drude and Gustave Wiedemann and received a Ph.D. in 1899. While in Germany he met Wilhelm Roentgen. Coolidge returned to the US to teach at MIT where he was associated with Arthur A. Noyes of the Chemistry Department, working on the electrical conductivity of aqueous solutions. Willis R. Whitney, under whom Coolidge had worked before going to Germany, became head of the newly formed General Electric Research Laboratory and he invited Coolidge to work with him. In 1905, Coolidge joined the staff of the GE laboratory and was associated with it for the remainder of his life. He developed ductile tungsten filaments to replace fragile carbon filaments as the material for electric light
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Edward Christopher Williams and His Impact on Librarianship.
Latimer, Carlos
Edward Christopher Williams had a major impact on librarianship, not only as the first documented African American to graduate from a library school, but also as a developer of education for librarians and as an active member of the American Library Association (ALA) and the Ohio Library Association. This study used the historical methodology…
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Orientation Perception in Williams Syndrome: Discrimination and Integration
Palomares, Melanie; Landau, Barbara; Egeth, Howard
2009-01-01
Williams Syndrome (WS) is a rare neurodevelopmental disorder, which stems from a genetic deletion on chromosome 7 and causes a profound weakness in visuospatial cognition. Our current study explores how orientation perception may contribute to the visuospatial deficits in WS. In Experiment 1, we found that WS individuals and normal 3-4 year olds…
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Bubbles That Change the Speed of Sound
Planinsic, Gorazd; Etkina, Eugenia
2012-01-01
The influence of bubbles on sound has long attracted the attention of physicists. In his 1920 book Sir William Bragg described sound absorption caused by foam in a glass of beer tapped by a spoon. Frank S. Crawford described and analyzed the change in the pitch of sound in a similar experiment and named the phenomenon the "hot chocolate effect."…
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Elison, Sarah; Stinton, Chris; Howlin, Patricia
2010-01-01
Previous studies have investigated trajectories of cognitive, language and adaptive functioning in Williams syndrome (WS) but little is known about how other aspects of the Williams syndrome behavioural phenotype change across the life-span. Therefore, the present study examined age associated changes in a number of different domains of…
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Comparison of the acute effects of Tulbaghia violacea William Henry ...
African Journals Online (AJOL)
William Henry Harvey (Alliaceae) on blood pressure and heart rate of ... (WKY), and compare the results obtained with those for adult spontaneously hypertensive rats (SHR). Methods: T. ... have similar secondary metabolites and biological ...
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ProRisk : risk analysis instrument : developed for William properties
van Doorn, W.H.W.; Egeberg, Ingrid; Hendrickx, Kristoff; Kahramaner, Y.; Masseur, B.; Waijers, Koen; Weglicka, K.A.
2005-01-01
This report presents a Risk Analysis Instrument developed for William Properties. Based on the analysis, it appears that the practice of Risk Analysis exists within the organization, yet rather implicit. The Risk Analysis Instrument comes with a package of four components: an activity diagram, a
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William Ospina y la búsqueda de la franja amarilla
Directory of Open Access Journals (Sweden)
Víctor Valero Bernal
2016-12-01
Full Text Available El objetivo de este artículo es el de analizar el ensayo «Lo que le falta a Colombia» del escritor William Ospina. En este ensayo Ospina profundiza en los principales problemas sociales y políticos que Colombia atravesaba a finales del s. XX así como en las posibles soluciones que podrían adoptarse. Los planteamientos que emplea el escritor colombiano pueden relacionarse con una gran variedad de conceptos propios del ámbito de la política y la sociología. A lo largo de este trabajo mostraremos las analogías existentes entre el análisis de William Ospina y las ideas de pensadores tan alejados en el tiempo como Thomas Hobbes, Rousseau, John Rawls o Charles Tilly.
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De Lorenzo, Francesca; Macchiaiolo, Marina; Carlevaris, Carla Maria; Bartuli, Andrea
2017-05-31
A new approach has been designed at the Bambino Gesù Children's Hospital in Rome aimed at increasing empowerment in Williams Syndrome individuals through tutor-assisted work activities. Williams Syndrome is characterized by a combination of distinguishing physical traits, congenital anomalies, intellectual disabilities, and a specific developmental profile.This manuscript describes the case of a Williams Syndrome patient.There are only few papers in the scientific literature describing interventions targeting improvement in the quality of life of adult Williams Syndrome individuals. Therefore, this experience may prove useful to several patients, their families, and the experts helping them.We described an example of intervention aimed at guiding and facilitating a Williams Syndrome patient within a work environment, taking into consideration the peaks and valleys of these individuals' specific abilities.Based on our results, we also stressed the need to promote a set of projects and initiatives aimed at enhancing as much as possible self-sufficiency and psycho-affective balance in Williams Syndrome individuals, in order to protect their dignity and self-esteem.
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Global stability of an SIR model with differential infectivity on complex networks
Yuan, Xinpeng; Wang, Fang; Xue, Yakui; Liu, Maoxing
2018-06-01
In this paper, an SIR model with birth and death on complex networks is analyzed, where infected individuals are divided into m groups according to their infection and contact between human is treated as a scale-free social network. We obtain the basic reproduction number R0 as well as the effects of various immunization schemes. The results indicate that the disease-free equilibrium is locally and globally asymptotically stable in some conditions, otherwise disease-free equilibrium is unstable and exists an unique endemic equilibrium that is globally asymptotically stable. Our theoretical results are confirmed by numerical simulations and a promising way for infectious diseases control is suggested.
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La Fondation William et Flora Hewlett | IDRC - International ...
International Development Research Centre (IDRC) Digital Library (Canada)
La Fondation William et Flora Hewlett. http://www.hewlett.org/ · What we do · Funding · Resources · About IDRC. Knowledge. Innovation. Solutions. Careers · Contact Us · Site map. Sign up now for IDRC news and views sent directly to your inbox each month. Subscribe · Copyright · Open access policy · Privacy policy ...
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Advocating for Inclusion of Children with Williams Syndrome
Self, Michelle A.
2010-01-01
The purpose of this study was to describe and explore the experience of inclusion of students with Williams syndrome, a rare genetic condition of a microdeletion on chromosome 7 which has medical, behavior, and cognitive issues. The study was conducted by gaining an understanding from the parents' point of view. The study was twofold. First, the…
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A Conversation with William A. Fowler Part II
Greenberg, John
2005-06-01
Physicist William A.Fowler initiated an experimental program in nuclear astrophysics after World War II. He recalls here the Steady State versus Big Bang controversy and his celebrated collaboration with Fred Hoyle and Geoffrey and Margaret Burbidge on nucleosynthesis in stars. He also comments on the shift away from nuclear physics in universities to large accelerators and national laboratories.
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Steinke, Hubert
2015-07-01
William Harvey's discovery of the circulation of the blood is often described as a product of the Scientific Revolution of the Seventeenth Century. Modern research has, however, shown thatHarvey followed the Aristotelian research tradition and thus tried to reveal the purpose of the organs through examination of various animals. His publication of 1628 has to be read as an argument of natural philosophy, or, more precisely, as a series of linked observations, experiments and philosophical reasonings from which the existence of circulation has to be deduced as a logical consequence. Harvey did not consider experiments as superior to philosophical reasoning nor intended he to create a new system of medicine. He believed in the vitality of the heart and the blood and rejected Francis Bacon's empirism and the mechanistic rationalism of Descartes. Harvey's contribution and originality lied less in his single observations and experiments but in the manner how he linked them with critical reasoning and how he accepted, presented and defended the ensuing radical findings.
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[Sir Arthur Conan Doyle, Sherlock Holmes and infectious diseases].
Ledermann D, Walter
2010-10-01
Besides a pleasant author of best sellers, Sir Arthur Conan Doyle was a medical doctor, writing excellent short stories about the exercise of his profession in England. However, even he mentions The British Medical Journal and The Lancet in the Sherlock Holmes's stories, when in the plot introduces infectious diseases, Conan Doyle ignores important discoveries in the field of tetanus. Anyway, the appearing of infectious diseases in the adventures of the detective are rare: one mention of tetanus, another of leprosy and- the most analyzed in medical literature a case of murder by inoculation of bacteria, probably the agent of melioidosis. Also he makes his hero discovers the toxic actions of a medusa and a transplant of solid organ. Little for a physician and less for an author who also wrote science fiction: it seems that the history of the great medical discoveries at the end of nineteenth century and beginning of the twentieth has passed by his side.., and he just couldn't see it.
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International Nuclear Information System (INIS)
DeCola, E.G.; Robertson, T.L.; Robertson, R.; Banta, J.
2004-01-01
This study assessed the need for an oil spill response plan for downstream coastal communities that could be affected by oil spilled from tankers travelling in Prince William Sound, Alaska. For the purpose of oil spill contingency planning, the State of Alaska has been divided into the Kodiak and Cook Inlet sub-areas that are at risk for downstream impacts from a Prince William Sound oil spill. The 1989 Exxon Valdez oil spill provided an example of a worst-case scenario oil spill from a tanker in Prince William Sound, but the oil spill planning system that has evolved in Alaska does not adequately plan for on oil spill that originates in one sub-area of the state, but impacts other sub-areas in the downstream spill path. This study analyzed the gaps that exist in the current response planning system in the Prince William Sound, Cook Inlet and Kodiak sub-areas. A method was proposed to improve the existing response plans so that emergency response teams are better prepared to manage cross-boundary oil spills originating in Prince William Sound. The proposed method focuses on nearshore response and sensitive areas protection for coastlines and communities that are at risk for oil spills from a tanker travelling the Trans-Alaska Pipeline System (TAPS). 11 refs., 3 figs
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Characterisation of Sleep Problems in Children with Williams Syndrome
Annaz, Dagmara; Hill, Catherine M.; Ashworth, Anna; Holley, Simone; Karmiloff-Smith, Annette
2011-01-01
Sleep is critical to optimal daytime functioning, learning and general health. In children with established developmental disorders sleep difficulties may compound existing learning difficulties. The purpose of the present study was to evaluate the prevalence and syndrome specificity of sleep problems in Williams syndrome (WS), a…
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2013-10-24
... DEPARTMENT OF EDUCATION William D. Ford Federal Direct Loan Program Repayment Plan Selection Form; Extension of Public Comment Period; Correction AGENCY: Department of Education. ACTION: Correction notice... entitled, ``William D. Ford Federal Direct Loan Program Repayment Plan Selection Form''. ED is extending...
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Amiri Moghaddam, Jamshid; Boehringer, Nils; Burdziak, Amal; Kunte, Hans-Jörg; Galinski, Erwin A; Schäberle, Till F
2016-02-03
Only a few myxobacteria are known to date which are classified as marine due to their salt-dependency. In this study, the salt tolerance mechanism of these bacteria was investigated. Therefore, a growth medium was designed, in which the mutated Escherichia coli strain BKA13 served as sole food source for the predatory, heterotrophic myxobacteria. This enabled measurement of the osmolytes without any background and revealed that the closely related strains Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1 developed different strategies to handle salt stress. P. pacifica SIR-1, which was grown between 1-4 % NaCl, relies solely on the accumulation of amino acids, while E. salina SWB007, which was grown between 0.5-3 % NaCl, employs, beside betaine, hydroxyectoine as the major compatible solute. In accordance with this analysis, only in the latter strain a gene locus was identified which codes for genes corresponding to the biosynthesis of betaine, ectoine, and hydroxyectoine.
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Deforestation and Secondary Growth in Rondonia, Brazil from SIR-C SAR and Landsat.SPOT data
Rignot, Eric; Salas, William A.; Skole, David L.
1996-01-01
Covers problems with existing data collected with high-resolution optical sensors. They say active microwave sensors could complement other sensors in getting through things like cloud cover. They analyzed SIR-C data in combination with Landsat TM data, a 9-year time series of SPOT XS data, and a preliminary field survey. They report findings and draw conclusions, including that SARs operating at long radar wavelengths, with both like and cross-polarizations, are needed for tropical deforestation studies.
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Fitrolaki, Michaela-Diana; Dimitriou, Helen; Venihaki, Maria; Katrinaki, Marianna; Ilia, Stavroula; Briassoulis, George
2016-08-01
Mammalian heat-shock-protein (HSP) 90α rapidly responses to environmental insults. We examined the hypothesis that not only serum HSP72 but also HSP90α is increased in the systemic inflammatory response syndrome (SIRS), severe-sepsis (SS), and/or sepsis (S) compared to healthy children (H); we assessed HSP90α relation to (a) multiple organ system failure (MOSF) and (b) inflammatory-metabolic response and severity of illness.A total of 65 children with S, SS, or SIRS and 25 H were included. ELISA was used to evaluate extracellular HSP90α and HSP72, chemiluminescence interleukins (ILs), flow-cytometry neutrophil-CD64 (nCD64)-expression.HSP90α, along with HSP72, were dramatically increased among MOSF patients. Patients in septic groups and SIRS had elevated HSP90α compared to H (P stress, fever, outcome endpoints, and predicted mortality and inversely related to the low-LDL/low-HDL stress metabolic pattern.
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Lyons, Christopher
2007-01-01
The Osler Library of the History of Medicine was opened in 1929 at McGill University, Montreal, Canada. Sir William Osler (1849-1919), arguably McGill's and Canada's most famous doctor at the time, had bequeathed his magnificent library of almost 8,000 historical works in medicine and, to a lesser extent, science and literature to the university. Under the 30-year reign of its first librarian, Dr. W W. Francis, the Osler Library became famous for its rare books and for its connection with Sir William. Since the 1950s, however, the library has pursued an active collection development policy for both primary and secondary material that has taken it far beyond Osler's original gift. The library has grown in both the size and scope of its holdings and the services it offers to scholars and students of the history of medicine. These have made the Osler Library a major resource centre for studies in the history of the health sciences. This article looks at the Osler Library today in the hopes of making the range of its collections and services better known to the Canadian and international communities.
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Gender Attribution and Gender Agreement in French Williams Syndrome
Boloh, Yves; Ibernon, Laure; Royer, Stephanie; Escudier, Frederique; Danillon, Aurelia
2009-01-01
Previous studies on grammatical gender in French individuals with Williams syndrome (WS) have led to conflicting findings and interpretations regarding keys abilities--gender attribution and gender agreement. New production data from a larger SW sample (N = 24) showed that gender attribution scores in SW participants exactly mirrored those of…
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Visually Guided Step Descent in Children with Williams Syndrome
Cowie, Dorothy; Braddick, Oliver; Atkinson, Janette
2012-01-01
Individuals with Williams syndrome (WS) have impairments in visuospatial tasks and in manual visuomotor control, consistent with parietal and cerebellar abnormalities. Here we examined whether individuals with WS also have difficulties in visually controlling whole-body movements. We investigated visual control of stepping down at a change of…
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Welsh, Richard L.
2008-01-01
The author discusses the pivotal roles of Sir Francis Campbell (1832-1914) and members of his family, especially his son Charles Campbell, in the evolution of the blindness field to a professional and reason-based service.
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Doğan, Özlem Akgün; Şimşek Kiper, Pelin Özlem; Utine, Gülen Eda; Alikaşifoğlu, Mehmet; Boduroğlu, Koray
2017-03-01
Williams syndrome (OMIM #194050) is a rare, well-recognized, multisystemic genetic condition affecting approximately 1/7,500 individuals. There are no marked regional differences in the incidence of Williams syndrome. The syndrome is caused by a hemizygous deletion of approximately 28 genes, including ELN on chromosome 7q11.2. Prenatal-onset growth retardation, distinct facial appearance, cardiovascular abnormalities, and unique hypersocial behavior are among the most common clinical features. Here, we report the case of a patient referred to us with distinct facial features and intellectual disability, who was diagnosed with Williams syndrome at the age of 37 years. Our aim is to increase awareness regarding the diagnostic features and complications of this recognizable syndrome among adult health care providers. Williams syndrome is usually diagnosed during infancy or childhood, but in the absence of classical findings, such as cardiovascular anomalies, hypercalcemia, and cognitive impairment, the diagnosis could be delayed. Due to the multisystemic and progressive nature of the syndrome, accurate diagnosis is critical for appropriate care and screening for the associated morbidities that may affect the patient's health and well-being.
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Olsen, M; Fahy, C J; Costi, D A; Kelly, A J; Burgoyne, L L
2014-09-01
Williams syndrome is a genetic disorder associated with cardiac pathology, including supravalvular aortic stenosis and coronary artery stenosis. Sudden cardiac death has been reported in the perioperative period and attributed to cardiovascular pathology. In this retrospective audit, case note and anaesthetic records were reviewed for all confirmed Williams syndrome patients who had received an anaesthetic in our institution between July 1974 and November 2009. There were a total of 108 anaesthetics administered in 29 patients. Twelve of the anaesthetics (11.1%) were associated with cardiac complications including cardiac arrest in two cases (1.85%). Of the two cardiac arrests, one patient died within the first 24 hours postanaesthetic and the other patient survived, giving an overall mortality of 0.9% (3.4%). We conclude that Williams syndrome confers a significant anaesthetic risk, which should be recognised and considered by clinicians planning procedures requiring general anaesthesia.
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Field Marshal Sir William J. Slim - Paragon of Moral and Ethical Courage
National Research Council Canada - National Science Library
Baylor, Richard
1998-01-01
... during the most desperate and brutal times. This paper looks closely at Field Marshal Slim's ethical development and leadership during his younger years, his senior leader years, and his later years...
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50 CFR Figure 4 to Subpart E of... - Prince William Sound Rural and Non-Rural Areas
2010-10-01
... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Prince William Sound Rural and Non-Rural Areas 4 Figure 4 to Subpart E of Part 300 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED... to Subpart E of Part 300—Prince William Sound Rural and Non-Rural Areas ER04NO09.010 [74 FR 57110...
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A mixed SIR-SIS model to contain a virus spreading through networks with two degrees
Essouifi, Mohamed; Achahbar, Abdelfattah
Due to the fact that the “nodes” and “links” of real networks are heterogeneous, to model computer viruses prevalence throughout the Internet, we borrow the idea of the reduced scale free network which was introduced recently. The purpose of this paper is to extend the previous deterministic two subchains of Susceptible-Infected-Susceptible (SIS) model into a mixed Susceptible-Infected-Recovered and Susceptible-Infected-Susceptible (SIR-SIS) model to contain the computer virus spreading over networks with two degrees. Moreover, we develop its stochastic counterpart. Due to the high protection and security taken for hubs class, we suggest to treat it by using SIR epidemic model rather than the SIS one. The analytical study reveals that the proposed model admits a stable viral equilibrium. Thus, it is shown numerically that the mean dynamic behavior of the stochastic model is in agreement with the deterministic one. Unlike the infection densities i2 and i which both tend to a viral equilibrium for both approaches as in the previous study, i1 tends to the virus-free equilibrium. Furthermore, since a proportion of infectives are recovered, the global infection density i is minimized. Therefore, the permanent presence of viruses in the network due to the lower-degree nodes class. Many suggestions are put forward for containing viruses propagation and minimizing their damages.
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Beyond Behaviour: Is Social Anxiety Low in Williams Syndrome?
Dodd, Helen F.; Schniering, Carolyn A.; Porter, Melanie A.
2009-01-01
Individuals with Williams syndrome (WS) exhibit striking social behaviour that may be indicative of abnormally low social anxiety. The present research aimed to determine whether social anxiety is unusually low in WS and to replicate previous findings of increased generalised anxiety in WS using both parent and self report. Fifteen individuals…
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Biblionef SA: Bringing books to the bookless | Williams | Innovation
African Journals Online (AJOL)
Biblionef SA: Bringing books to the bookless. Jean Williams. Abstract. No abstract available. Innovation (2003) No. 26, pp 43-47. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...
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William Knocke receives 2008 Virginia Outstanding Civil Engineer Award
Daniilidi, Christina
2008-01-01
William R. Knocke, W.C. English Professor and head of the Charles E. Via, Jr. Department of Civil and Environmental Engineering at Virginia Tech, was awarded the 2008 Virginia Outstanding Civil Engineer Award at the Virginia Section of the American Society of Civil Engineers' (ASCE) banquet, held recently in Williamsburg, Va.
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Language and Literacy Development of Children with Williams Syndrome
Mervis, Carolyn B.
2009-01-01
Williams syndrome is a rare neurodevelopmental disorder caused by deletion of approximately 25 genes on chromosome 7q11.23. Children with the syndrome evidence large individual differences in both broad language and reading abilities. Nevertheless, as a group, children with this syndrome show a consistent pattern characterized by relative…
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Musicality Correlates with Sociability and Emotionality in Williams Syndrome
Ng, Rowena; Lai, Philip; Levitin, Daniel J.; Bellugi, Ursula
2013-01-01
Williams syndrome (WS) is a neurogenetic developmental disorder characterized by peaks and valleys of cognitive abilities. One peak that has been understudied is the affinity that many individuals with WS have with music. It remains unknown whether their high levels of musical interest, skill, and expressivity are related to their sociable…
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Pulmonary arterial stent implantation in an adult with Williams syndrome
Reesink, Herre J.; Henneman, Onno D. F.; van Delden, Otto M.; Biervliet, Jules D.; Kloek, Jaap J.; Reekers, Jim A.; Bresser, Paul
2007-01-01
We report a 38-year-old patient who presented with pulmonary hypertension and right ventricular dysfunction due to pulmonary artery stenoses as a manifestation of Williams syndrome, mimicking chronic thromboembolic pulmonary hypertension. The patient was treated with balloon angioplasty and stent
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2012-11-01
..., and 685 Federal Perkins Loan Program, Federal Family Education Loan Program, and William D. Ford... 685 RIN 1840-AD05 [Docket ID ED-2012-OPE-0010] Federal Perkins Loan Program, Federal Family Education... (Perkins Loan) program, Federal Family Education Loan (FFEL) program, and William D. Ford Federal Direct...
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Sudduth, Christopher L; Overton, Elizabeth C; Lyu, Peter F; Rimawi, Ramzy H; Buchman, Timothy G
2017-06-01
Using administrative codes and minimal physiologic and laboratory data, we sought a high-specificity identification strategy for patients whose sepsis initially appeared during their ICU stay. We studied all patients discharged from an academic hospital between September 1, 2013 and October 31, 2014. Administrative codes and minimal physiologic and laboratory criteria were used to identify patients at high risk of developing the onset of sepsis in the ICU. Two clinicians then independently reviewed the patient record to verify that the screened-in patients appeared to become septic during their ICU admission. Clinical chart review verified sepsis in 437/466 ICU stays (93.8%). Of these 437 encounters, only 151 (34.6%) were admitted to the ICU with neither SIRS nor evidence of infection and therefore appeared to become septic during their ICU stay. Selected administrative codes coupled to SIRS criteria and applied to patients admitted to ICU can yield up to 94% authentic sepsis patients. However, only 1/3 of patients thus identified appeared to become septic during their ICU stay. Studies that depend on high-intensity monitoring for description of the time course of sepsis require clinician review and verification that sepsis initially appeared during the monitoring period. Copyright © 2017 Elsevier Inc. All rights reserved.
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Jarrold, Christopher; Phillips, Caroline; Baddeley, Alan D
2007-01-01
A main aim of this study was to test the claim that individuals with Williams syndrome have selectively impaired memory for spatial as opposed to visual information. The performance of 16 individuals with Williams syndrome (six males, 10 females; mean age 18y 7mo [SD 7y 6mo], range 9y 1mo-30y 7mo) on tests of short-term memory for item and…
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Threshold Dynamics in Stochastic SIRS Epidemic Models with Nonlinear Incidence and Vaccination
Directory of Open Access Journals (Sweden)
Lei Wang
2017-01-01
Full Text Available In this paper, the dynamical behaviors for a stochastic SIRS epidemic model with nonlinear incidence and vaccination are investigated. In the models, the disease transmission coefficient and the removal rates are all affected by noise. Some new basic properties of the models are found. Applying these properties, we establish a series of new threshold conditions on the stochastically exponential extinction, stochastic persistence, and permanence in the mean of the disease with probability one for the models. Furthermore, we obtain a sufficient condition on the existence of unique stationary distribution for the model. Finally, a series of numerical examples are introduced to illustrate our main theoretical results and some conjectures are further proposed.
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Prince William Sound, Alaska ESI: ESI (Environmental Sensitivity Index Shoreline Types)
National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) data for Prince William Sound, Alaska. ESI data characterize estuarine environments and wildlife by...
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Royston, R.; Oliver, C.; Moss, J.; Adams, D.; Berg, K.; Burbidge, C.; Howlin, P.; Nelson, L.; Stinton, C.; Waite, J.
2018-01-01
This study describes the profile of repetitive behaviour in individuals with Williams syndrome, utilising cross-syndrome comparisons with people with Prader-Willi and Down syndromes. The Repetitive Behaviour Questionnaire was administered to caregivers of adults with Williams (n = 96), Prader-Willi (n = 103) and Down (n = 78) syndromes. There were…
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Astronaut William Fisher preparing to train in the WETF
1985-01-01
Astronaut William Fisher is shown in his extravehicular mobility unit (EMU) preparing to train in the Weightless Environment Training Facility (WETF). He is wearing the communications carrier assembly but not the full helmet (32102); Reflections of the WETF can be seen on the closed visor of the EMU helmet Fiser is wearing (32103).
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Climatic data for Williams Lake, Hubbard County, Minnesota, 1983
Sturrock, A.M.; Rosenberry, D.O.; Engelbrecht, L.G.; Gothard, W.A.; Winter, T.C.
1984-01-01
Research on the hydrology of Williams Lake, north-central Minnesota includes study of evaporation. Presented here are those climatic data needed for energy-budget and mass-transfer studies,including: water-surface temperature, dry-bulb and wet-bulb air temperatures, wind speed, precipitation, and solar radiation. Data are collected at raft and land stations.
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On pulse vaccine strategy in a periodic stochastic SIR epidemic model
International Nuclear Information System (INIS)
Wang, Fengyan; Wang, Xiaoyi; Zhang, Shuwen; Ding, Changming
2014-01-01
A periodic stochastic SIR epidemic model with pulse vaccination is studied. The system has global positive solutions and under some conditions it admits a unique positive periodic disease-free solution, which is globally exponentially stable in mean square. The mathematical expectation and variance of the positive periodic solution are obtained. Two threshold parameters R 1 and R 2 (R 1 >R 2 ) are identified; if R 1 <1, the susceptible will be persistent in the mean and the disease will go to extinction; if R 2 >1, the susceptible and the disease will be weakly persistent in the mean. We show that by repeatedly vaccinating the susceptible population in series of pulses, it is possible to eradicate the infective from the entire model population in the random environment
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Granular statistical mechanics - Building on the legacy of Sir Sam Edwards
Blumenfeld, Raphael
When Sir Sam Edwards laid down the foundations for the statistical mechanics of jammed granular materials he opened a new field in soft condensed matter and many followed. In this presentation we review briefly the Edwards formalism and some of its less discussed consequences. We point out that the formalism is useful for other classes of systems - cellular and porous materials. A certain shortcoming of the original formalism is then discussed and a modification to overcome it is proposed. Finally, a derivation of an equation of state with the new formalism is presented; the equation of state is analogous to the PVT relation for thermal gases, relating the volume, the boundary stress and measures of the structural and stress fluctuations. NUDT, Changsha, China, Imperial College London, UK, Cambridge University, UK.
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Generalized Bragg-Williams method for 'antiferromagnetic' lattice gases
International Nuclear Information System (INIS)
Osorio, R.
1983-01-01
The many-sublattice Bragg-Williams approximation of statistical mechanics is applied to the two-dimensional square and triangular lattice-gas models with nearest-neighbor repulsive interactions. Each problem is solved through both the canonical and grand-canonical methods. The present treatment emphasizes the duality between concentration and chemical potential and illustrates the appearance of first- and second -order transitions in each method. (Author) [pt
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Jarrold, Christopher; Phillips, Caroline; Baddeley, Alan D
2007-04-01
A main aim of this study was to test the claim that individuals with Williams syndrome have selectively impaired memory for spatial as opposed to visual information. The performance of 16 individuals with Williams syndrome (six males, 10 females; mean age 18y 7mo [SD 7y 6mo], range 9y 1mo-30y 7mo) on tests of short-term memory for item and location information was compared with that shown by individuals with moderate learning difficulties (12 males, four females; mean age 10y 3mo [SD 1y], range 8y 6mo-11y 7mo) and typically developing children (six males, 10 females; mean age 6y 8mo [SD 7mo], range 5y 10mo-7y 9mo) of an equivalent level of visuospatial ability. A second aim was to determine whether individuals had impaired ability to 'bind' visual spatial information when required to recall 'item in location' information. In contrast to previous findings, there was no evidence that individuals with Williams syndrome were more impaired in the spatial than the visual memory condition. However, individuals with both Williams syndrome and moderate learning difficulties showed impaired memory for item in location information, suggesting that problems of binding may be generally associated with learning disability.
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Williams Syndrome: Daily Challenges and Positive Impact on the Family
Scallan, Susan; Senior, Joyce; Reilly, Colin
2011-01-01
Background: Despite the distinctive physical, cognitive, personality and behavioural characteristics associated with Williams syndrome, few studies to date have examined parental experiences of raising a child with this genetic syndrome. Methods: This explorative pilot study employed predominantly qualitative methodologies via face-to-face…
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77 FR 76414 - William D. Ford Federal Direct Loan Program
2012-12-28
... Federal Direct Loan Program AGENCY: Department of Education. ACTION: Final regulations; correction... Loan (Perkins Loan) Program; the Federal Family Education Loan (FFEL) Program; and the William D. Ford Federal Direct Loan (Direct Loan) Program, including the Public Service Loan Forgiveness (PSLF) Program...
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Development of Immunopathobiogenesis on SIRS-Sepsis
Directory of Open Access Journals (Sweden)
A Guntur Hermawan
2009-04-01
Full Text Available Over the past decade, sepsis has been diagnosed according to consensus guidelines established in 1991 as an infection in addition to the symptoms of systemic inflammatory response syndrome (SIRS. In addition to the previous criteria, the 2001 conference added several new diagnostic criteria for sepsis. Of particular interest was the inclusion of the biomarkers procalcitonin (PCT and C-reactive protein (CRP, despite the overall conclusion that it was premature to use biomarkers for sepsis diagnosis. The primary recommendation of the panel was the implementation of the Predisposition, insult Infection, Response, and Organ dysfunction (PIRO.The immune system has traditionally been devided into innate and adaptive components, each of which has a different role and function in defending the host against infectious agents. Stimulation of different TLRs induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also increasing evidence supports an additional critical role for TLRs in orchestrating the development of adaptive immune responses. The superantigens are able to induce toxic shock syndrome and can sometimes cause multiple organ failure via adaptive immune system. The superantigenic activity of the bacterial exotoxins can be attributed to their ability to cross-link major histocompatibility complex class II molecules on antigen-presenting cells outside the peptide groove with T-cell receptors to form a trimolecular complex. This trimolecular interaction leads to uncontrolled release of a number of proinflammatory cytokines. Proinflammatory cytokines especially IFN-γ and TNF-α, the key cytokines causing toxic shock syndrome. KEYWORDS: sepsis, innate immunity, adaptive.
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Williams' paradox and the role of phenotypic plasticity in sexual systems.
Leonard, Janet L
2013-10-01
As George Williams pointed out in 1975, although evolutionary explanations, based on selection acting on individuals, have been developed for the advantages of simultaneous hermaphroditism, sequential hermaphroditism and gonochorism, none of these evolutionary explanations adequately explains the current distribution of these sexual systems within the Metazoa (Williams' Paradox). As Williams further pointed out, the current distribution of sexual systems is explained largely by phylogeny. Since 1975, we have made a great deal of empirical and theoretical progress in understanding sexual systems. However, we still lack a theory that explains the current distribution of sexual systems in animals and we do not understand the evolutionary transitions between hermaphroditism and gonochorism. Empirical data, collected over the past 40 years, demonstrate that gender may have more phenotypic plasticity than was previously realized. We know that not only sequential hermaphrodites, but also simultaneous hermaphrodites have phenotypic plasticity that alters sex allocation in response to social and environmental conditions. A focus on phenotypic plasticity suggests that one sees a continuum in animals between genetically determined gonochorism on the one hand and simultaneous hermaphroditism on the other, with various types of sequential hermaphroditism and environmental sex determination as points along the spectrum. Here I suggest that perhaps the reason we have been unable to resolve Williams' Paradox is because the problem was not correctly framed. First, because, for example, simultaneous hermaphroditism provides reproductive assurance or dioecy ensures outcrossing does not mean that there are no other evolutionary paths that can provide adaptive responses to those selective pressures. Second, perhaps the question we need to ask is: What selective forces favor increased versus reduced phenotypic plasticity in gender expression? It is time to begin to look at the question
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Infrared astronomy seeing the heat : from William Herschel to the Herschel space observatory
Clements, David L
2014-01-01
Uncover the Secrets of the Universe Hidden at Wavelengths beyond Our Optical GazeWilliam Herschel's discovery of infrared light in 1800 led to the development of astronomy at wavelengths other than the optical. Infrared Astronomy - Seeing the Heat: from William Herschel to the Herschel Space Observatory explores the work in astronomy that relies on observations in the infrared. Author David L. Clements, a distinguished academic and science fiction writer, delves into how the universe works, from the planets in our own Solar System to the universe as a whole. The book first presents the major t
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The Role of Spiral Multidetector Dynamic CT in the Study of Williams-Campbell Syndrome
International Nuclear Information System (INIS)
Scioscio, V. di; Zompatori, M.; Mistura, I.; Montanari, P.; Santilli, L.; Luccaroni, R.; Sverzellati, N.
2006-01-01
Williams-Campbell syndrome is a cystic bronchiectatic disease secondary to deficiency or defect of cartilaginous plates in the wall of the airways. In the literature, two main forms are suggested: congenital and acquired (post-infectious). The most frequent symptoms are represented by recurrent pulmonary infections from childhood. Multislice spiral dynamic CT has a major role in the study of cystic pulmonary disease and in differentiating Williams-Campbell syndrome from the other causes of cystic bronchiectasis, in which even lung function tests can give deceptive results
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The Role of Spiral Multidetector Dynamic CT in the Study of Williams-Campbell Syndrome
Energy Technology Data Exchange (ETDEWEB)
Scioscio, V. di; Zompatori, M.; Mistura, I.; Montanari, P.; Santilli, L.; Luccaroni, R.; Sverzellati, N. [Medical Univ. of Bologna, S. Orsola-Malpighi Policlinic (Italy). Dept. of Radiology
2006-10-15
Williams-Campbell syndrome is a cystic bronchiectatic disease secondary to deficiency or defect of cartilaginous plates in the wall of the airways. In the literature, two main forms are suggested: congenital and acquired (post-infectious). The most frequent symptoms are represented by recurrent pulmonary infections from childhood. Multislice spiral dynamic CT has a major role in the study of cystic pulmonary disease and in differentiating Williams-Campbell syndrome from the other causes of cystic bronchiectasis, in which even lung function tests can give deceptive results.
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Santosa, Katherine B; Fattah, Adel; Gavilán, Javier; Hadlock, Tessa A; Snyder-Warwick, Alison K
2017-07-01
There is no widely accepted assessment tool or common language used by clinicians caring for patients with facial palsy, making exchange of information challenging. Standardized photography may represent such a language and is imperative for precise exchange of information and comparison of outcomes in this special patient population. To review the literature to evaluate the use of facial photography in the management of patients with facial palsy and to examine the use of photography in documenting facial nerve function among members of the Sir Charles Bell Society-a group of medical professionals dedicated to care of patients with facial palsy. A literature search was performed to review photographic standards in patients with facial palsy. In addition, a cross-sectional survey of members of the Sir Charles Bell Society was conducted to examine use of medical photography in documenting facial nerve function. The literature search and analysis was performed in August and September 2015, and the survey was conducted in August and September 2013. The literature review searched EMBASE, CINAHL, and MEDLINE databases from inception of each database through September 2015. Additional studies were identified by scanning references from relevant studies. Only English-language articles were eligible for inclusion. Articles that discussed patients with facial palsy and outlined photographic guidelines for this patient population were included in the study. The survey was disseminated to the Sir Charles Bell Society members in electronic form. It consisted of 10 questions related to facial grading scales, patient-reported outcome measures, other psychological assessment tools, and photographic and videographic recordings. In total, 393 articles were identified in the literature search, 7 of which fit the inclusion criteria. Six of the 7 articles discussed or proposed views specific to patients with facial palsy. However, none of the articles specifically focused on
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Climatic data for Williams Lake, Hubbard County, Minnesota, 1985
Sturrock, A.M.; Rosenberry, D.O.; Winter, T.C.
1987-01-01
Research on the hydrology of Williams Lake, north-central Minnesota includes study of evaporation. Presented here are those climatic data needed for energy-budget and mass-transfer studies, including: water-surface temperature, dry-bulb and wet-bulb air temperatures, wind speed, precipitation, and solar and atmospheric radiation. Data are collected at raft and land stations.
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Climatic data for Williams Lake, Hubbard County, Minnesota, 1984
Sturrock, A.M.; Rosenberry, D.O.; Scarborough, J.L.; Winter, T.C.
1986-01-01
Research on the hydrology of Williams Lake, north-central Minnesota includes study of evaporation. Presented here are those climatic data needed for energy-budget and mass-transfer studies, including: water-surface temperature, dry-bulb and wet-bulb air temperatures, wind speed, precipitation, and solar and atmospheric radiation. Data are collected at raft and land stations.
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Random Thoughts on William Shakespeare and Medicine
KV Sahasranam
2017-01-01
Medicine and literature have always been connected over the ages. William Shakespeare (1564-1616) is no exception. There are plenty of references to medicine and diseases in the works of Shakespeare. The knowledge which Shakespeare has of medical conditions is much more than is expected of a common man. This is attributed to his association with practitioners of his time and reading of contemporary texts in medicine. Also his son in law Dr. John Hall who married Susanna, Shakespeare's eldest ...
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Mapping cultural resource sites for the Prince William Sound Graphical Resource Database
International Nuclear Information System (INIS)
Wooley, C. B.; O'Brien, D. K.; Hillman, S. O.
1997-01-01
A software package for mapping digital data 'layers' of environmentally and/or culturally sensitive areas such as seabird colonies, seal haulouts, and sea otter concentrations in Prince William Sound and adjoining areas of southern Alaska has been developed by the Alyeska Pipeline Service Company. The data is to be added to an environmental computer mapping database. More than 1,800 known and reported coastal cultural resource sites have been identified. The database is part of the Prince William Sound Tanker Oil Discharge Prevention and Contingency Plan. The mappable data layers can be used to plan and execute whatever site protection program may be necessary, thus enhancing effective cultural resource protection during an oil spill response. 22 refs., 4 figs
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2012-06-01
... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 8866-010] William J. Stevenson, Estate of Lynn E. Stevenson, Black Canyon Bliss, LLC; Notice of Application for Transfer of License, and Soliciting Comments and Motions To Intervene On April 23, 2012, William J. Stevenson, Estate...
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2013-06-04
... DEPARTMENT OF EDUCATION Annual Updates to the Income Contingent Repayment (ICR) Plan Formula for 2013--William D. Ford Federal Direct Loan Program Catalog of Federal Domestic Assistance (CFDA) Number... free, at 1- 800-877-8339. SUPPLEMENTARY INFORMATION: Under the William D. Ford Federal Direct Loan...
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Zhao, Xuan; Lu, Lulu; Qi, Yonghao; Li, Miao; Zhou, Lijun
2017-10-01
The naturally occurring anthraquinone emodin has been serving primarily as an anti-bacterial and anti-inflammatory agent. However, little is known about its potential on anti-aging. This investigation examined the effect of emodin on lifespan and focused on its physiological molecular mechanisms in vivo. Using Caenorhabditis elegans (C. elegans) as an animal model, we found emodin could extend lifespan of worms and improve their antioxidant capacity. Our mechanistic studies revealed that emodin might function via insulin/IGF-1 signaling (IIS) pathway involving, specifically the core transcription factor DAF-16. Quantitative RT-PCR results illustrated that emodin up-regulated transcription of DAF-16 target genes which express antioxidants to promote antioxidant capacity and lifespan of worms. In addition, attenuated effect in sir-2.1 mutants suggests that emodin likely functioned in a SIR-2.1-dependent manner. Our study uncovers a novel role of emodin in prolonging lifespan and supports the understanding of emodin being a beneficial dietary supplement.
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77 FR 72960 - William D. Ford Federal Direct Loan Program
2012-12-07
... Federal Direct Loan Program AGENCY: Office of Postsecondary Education, Department of Education. ACTION... document to establish the date for the early implementation of William D. Ford Federal Direct Loan (Direct Loan) program regulations that establish a new income-contingent repayment plan based on the President...
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Directory of Open Access Journals (Sweden)
Antony Kaliyadan
2011-01-01
Full Text Available Lung herniation is a relatively rare clinical entity that is most commonly either congenital or acquired traumatically. We describe a case of spontaneous lung herniation secondary to acute cough in an obese male smoker complicated by contralateral acute lung injury and systemic inflammatory response syndrome (SIRS. Mechanisms of lung herniation, classification, diagnosis, and management will be discussed.
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Case report of sudden death in a child with Williams syndrome ...
African Journals Online (AJOL)
A two year old child, confirmed with Williams syndrome (WS) ... and no relevant cardiac history such as chest pain or episodes ... brain, abdominal and pelvic organ blocks. .... a fully functional operating theatre complex presents a number.
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Energy Technology Data Exchange (ETDEWEB)
NONE
2015-06-15
Roentgen and the Birth of Modern Medical Physics – Perry Sprawls Wilhelm Roentgen is well known for his discovery of x-radiation. What is less known and appreciated is his intensive research following the discovery to determine the characteristics of the “new kind of radiation” and demonstrate its great value for medical purposes. In this presentation we will imagine ourselves in Roentgen’s mind and follow his thinking, including questions and doubts, as he designs and conducts a series of innovative experiments that provided the foundation for the rapid growth of medical physics. Learning Objectives: Become familiar with the personal characteristics and work of Prof. Roentgen that establishes him as an inspiring model for the medical physics profession. Observe the thought process and experiments that determined and demonstrated the comprehensive characteristics of x-radiation. The AAPM Award Eponyms: William D. Coolidge, Edith H. Quimby, and Marvin M.D. Williams - Who were they and what did they do? – Lawrence N. Rothenberg William David Coolidge (1873–1975) William Coolidge was born in Hudson, NY in 1873. He obtained his BS at the Massacusetts Institute of Technology in 1896. Coolidge then went to the University of Leipzig, Germany for graduate study with physicists Paul Drude and Gustave Wiedemann and received a Ph.D. in 1899. While in Germany he met Wilhelm Roentgen. Coolidge returned to the US to teach at MIT where he was associated with Arthur A. Noyes of the Chemistry Department, working on the electrical conductivity of aqueous solutions. Willis R. Whitney, under whom Coolidge had worked before going to Germany, became head of the newly formed General Electric Research Laboratory and he invited Coolidge to work with him. In 1905, Coolidge joined the staff of the GE laboratory and was associated with it for the remainder of his life. He developed ductile tungsten filaments to replace fragile carbon filaments as the material for electric light
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International Nuclear Information System (INIS)
2015-01-01
Roentgen and the Birth of Modern Medical Physics – Perry Sprawls Wilhelm Roentgen is well known for his discovery of x-radiation. What is less known and appreciated is his intensive research following the discovery to determine the characteristics of the “new kind of radiation” and demonstrate its great value for medical purposes. In this presentation we will imagine ourselves in Roentgen’s mind and follow his thinking, including questions and doubts, as he designs and conducts a series of innovative experiments that provided the foundation for the rapid growth of medical physics. Learning Objectives: Become familiar with the personal characteristics and work of Prof. Roentgen that establishes him as an inspiring model for the medical physics profession. Observe the thought process and experiments that determined and demonstrated the comprehensive characteristics of x-radiation. The AAPM Award Eponyms: William D. Coolidge, Edith H. Quimby, and Marvin M.D. Williams - Who were they and what did they do? – Lawrence N. Rothenberg William David Coolidge (1873–1975) William Coolidge was born in Hudson, NY in 1873. He obtained his BS at the Massacusetts Institute of Technology in 1896. Coolidge then went to the University of Leipzig, Germany for graduate study with physicists Paul Drude and Gustave Wiedemann and received a Ph.D. in 1899. While in Germany he met Wilhelm Roentgen. Coolidge returned to the US to teach at MIT where he was associated with Arthur A. Noyes of the Chemistry Department, working on the electrical conductivity of aqueous solutions. Willis R. Whitney, under whom Coolidge had worked before going to Germany, became head of the newly formed General Electric Research Laboratory and he invited Coolidge to work with him. In 1905, Coolidge joined the staff of the GE laboratory and was associated with it for the remainder of his life. He developed ductile tungsten filaments to replace fragile carbon filaments as the material for electric light
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Dalton, Gavin; Trager, Scott C.; Abrams, Don Carlos; Carter, David; Bonifacio, Piercarlo; Aguerri, J. Alfonso L.; MacIntosh, Mike; Evans, Chris; Lewis, Ian; Navarro, Ramon; Agocs, Tibor; Dee, Kevin; Rousset, Sophie; Tosh, Ian; Middleton, Kevin; Pragt, Johannes; Terrett, David; Brock, Matthew; Benn, Chris; Verheijen, Marc; Cano Infantes, Diego; Bevil, Craige; Steele, Iain; Mottram, Chris; Bates, Stuart; Gribbin, Francis J.; Rey, Jürg; Rodriguez, Luis Fernando; Delgado, Jose Miguel; Guinouard, Isabelle; Walton, Nic; Irwin, Michael J.; Jagourel, Pascal; Stuik, Remko; Gerlofsma, Gerrit; Roelfsma, Ronald; Skillen, Ian; Ridings, Andy; Balcells, Marc; Daban, Jean-Baptiste; Gouvret, Carole; Venema, Lars; Girard, Paul
We present the preliminary design of the WEAVE next generation spectroscopy facility for the William Herschel Telescope (WHT), principally targeting optical ground-based follow up of upcoming ground-based (LOFAR) and spacebased (Gaia) surveys. WEAVE is a multi-object and multi-IFU facility utilizing
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Arterial Hypertension in a Child with Williams-Beuren Syndrome (7q11.23 Chromosomal Deletion
Directory of Open Access Journals (Sweden)
Cristina de Sylos
2002-08-01
Full Text Available We report the case of a 7-year-old male child diagnosed with Williams-Beuren syndrome and arterial hypertension refractory to clinical treatment. The diagnosis was confirmed by genetic study. Narrowing of the descending aorta and stenosis of the renal arteries were also diagnosed. Systemic vascular alterations caused by deletion of the elastin gene may occur early in individuals with Williams-Beuren syndrome, leading to the clinical manifestation of systemic arterial hypertension refractory to drug treatment.
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Jia, Chun-Sheng; Liang, Guang-Chuan; Peng, Xiao-Long; Tang, Hong-Ming; Zhang, Lie-Hui
2014-06-01
By employing the dissociation energy and the equilibrium bond length for a diatomic molecule as explicit parameters, we generate an improved form of the Williams-Poulios potential energy model. It is found that the negative Williams-Poulios potential model is equivalent to the Manning-Rosen potential model for diatomic molecules. We observe that the Manning-Rosen potential is superior to the Morse potential in reproducing the interaction potential energy curves for the {{a}3 Σu+} state of the 6Li2 molecule and the {{X}1 sum+} state of the SiF+ molecule.
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Atypical Sleep Architecture and Altered EEG Spectra in Williams Syndrome
Gombos, F.; Bodizs, R.; Kovacs, I.
2011-01-01
Background: Williams syndrome (WS) is a neurodevelopmental genetic disorder characterised by physical abnormalities and a distinctive cognitive profile with intellectual disabilities (IDs) and learning difficulties. Methods: In our study, nine adolescents and young adults with WS and 9 age- and sex-matched typically developing (TD) participants…
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Comparison of the acute effects of Tulbaghia violacea William Henry ...
African Journals Online (AJOL)
Purpose: To assess the effect of the crude methanol leaf extracts of Tulbaghia violacea William Henry Harvey (Alliaceae) on blood pressure (BP) and heart rate in ageing normotensive Wistar Kyoto rats (WKY), and compare the results obtained with those for adult spontaneously hypertensive rats (SHR). Methods: T.
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Newton's gift how Sir Isaac Newton unlocked the system of the world
Berlinski, David
2000-01-01
Sir Isaac Newton, creator of the first and perhaps most important scientific theory, is a giant of the scientific era. Despite this, he has remained inaccessible to most modern readers, indisputably great but undeniably remote. In this witty, engaging, and often moving examination of Newton's life, David Berlinski recovers the man behind the mathematical breakthroughs. The story carries the reader from Newton's unremarkable childhood to his awkward undergraduate days at Cambridge through the astonishing year in which, working alone, he laid the foundation for his system of the world, his Principia Mathematica, and to the subsequent monumental feuds that poisoned his soul and wearied his supporters. An edifying appreciation of Newton's greatest accomplishment, Newton's Gift is also a touching celebration of a transcendent man.
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Zhang, Juping; Yang, Chan; Jin, Zhen; Li, Jia
2018-07-14
In this paper, the correlation coefficients between nodes in states are used as dynamic variables, and we construct SIR epidemic dynamic models with correlation coefficients by using the pair approximation method in static networks and dynamic networks, respectively. Considering the clustering coefficient of the network, we analytically investigate the existence and the local asymptotic stability of each equilibrium of these models and derive threshold values for the prevalence of diseases. Additionally, we obtain two equivalent epidemic thresholds in dynamic networks, which are compared with the results of the mean field equations. Copyright © 2018 Elsevier Ltd. All rights reserved.
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Optimizing Real-Time Vaccine Allocation in a Stochastic SIR Model.
Directory of Open Access Journals (Sweden)
Chantal Nguyen
Full Text Available Real-time vaccination following an outbreak can effectively mitigate the damage caused by an infectious disease. However, in many cases, available resources are insufficient to vaccinate the entire at-risk population, logistics result in delayed vaccine deployment, and the interaction between members of different cities facilitates a wide spatial spread of infection. Limited vaccine, time delays, and interaction (or coupling of cities lead to tradeoffs that impact the overall magnitude of the epidemic. These tradeoffs mandate investigation of optimal strategies that minimize the severity of the epidemic by prioritizing allocation of vaccine to specific subpopulations. We use an SIR model to describe the disease dynamics of an epidemic which breaks out in one city and spreads to another. We solve a master equation to determine the resulting probability distribution of the final epidemic size. We then identify tradeoffs between vaccine, time delay, and coupling, and we determine the optimal vaccination protocols resulting from these tradeoffs.
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Kittler, Phyllis M.; Krinsky-McHale, Sharon J.; Devenny, Darlynne A.
2008-01-01
Behavioral phenotypes of individuals with Williams syndrome and individuals with Down syndrome have been contrasted in relation to short-term memory. People with Down syndrome are stronger visuospatially and those with Williams syndrome are stronger verbally. We examined short-term memory, then explored whether dual-task processing further…
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2012-05-22
... DEPARTMENT OF EDUCATION Annual Updates to the Income Contingent Repayment (ICR) Plan Formula for 2012; William D. Ford Federal Direct Loan Program AGENCY: Federal Student Aid, Department of Education... announces the annual updates to the ICR plan formula for 2012. Under the William D. Ford Federal Direct Loan...
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2012-04-06
... DEPARTMENT OF EDUCATION Annual Updates to the Income Contingent Repayment (ICR) Plan Formula for 2011; William D. Ford Federal Direct Loan Program AGENCY: Federal Student Aid, Department of Education... announces the annual updates to the ICR plan formula for 2011. Under the William D. Ford Federal Direct Loan...
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A child of Williams-Beuren syndrome for inguinal hernia repair: Perioperative management concerns
Directory of Open Access Journals (Sweden)
Sangeeta Deka
2016-01-01
Full Text Available Williams-Beuren syndrome, commonly known as Williams syndrome (WS, is a multi-organ disorder. The principal anomalies of the syndrome are developmental delay, unusual craniofacial dysmorphic features, and cardiovascular anomalies such as valvular or supravalvular aortic stenosis, pulmonary artery stenosis, and coronary insufficiency. Sudden cardiac death during minor procedures even in the absence of gross cardiovascular pathology is the most dreaded complication in these patients. A 7-year-old child with WS was posted for left-sided inguinal hernia repair under general anesthesia. Our article describes the uneventful perioperative course of the patient and highlights the concerns and complications that may be an integral part with the syndrome.
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The Interplay between Anxiety and Social Functioning in Williams Syndrome
Riby, Deborah M.; Hanley, Mary; Kirk, Hannah; Clark, Fiona; Little, Katie; Fleck, Ruth; Janes, Emily; Kelso, Linzi; O'Kane, Fionnuala; Cole-Fletcher, Rachel; Allday, Marianne Hvistendahl; Hocking, Darren; Cornish, Kim; Rodgers, Jacqui
2014-01-01
The developmental disorder Williams syndrome (WS) has been associated with an atypical social profile of hyper-sociability and heightened social sensitivity across the developmental spectrum. In addition, previous research suggests that both children and adults with WS have a predisposition towards anxiety. The current research aimed to explore…
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Ronald William Hodges, 1934-2017: Eminent Lepidopterist and Great Mentor
Dr. Ronald William Hodges (1934-2017) was an eminent lepidopterist and former Research Leader of the Systematic Entomology Laboratory from 1976 to 1979. He published on 117 genera (21 new), 806 species (351 new), 36 subfamilies (7 new), and 16 families (7 new) about gelechioid micromoths. He was awa...
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Arvidson, R. E.
1983-01-01
The utility of shuttle imaging radar (SIR-A) data was evaluated in several geological and environmental contexts. For the Ozark Plateau of southern Missouri, SIR-A data were of little use in mapping structural features, because of generally uniform returns. For western Illinois, little was to be gained in terms of identifying land use categories by examining differences between overlapping passes. For southern Australia (Koonamore Station), information ion vegetation types that was not obtainable from LANDSAT MSS data alone was obtained. Specifically, high SIR-A returns in the Australian site were found to correlate with locations where shrubs increase surface roughness appreciably. The Australian study site results demonstrate the synergy of acquiring spectral reflectance and radar data over the same location and time. Such data are especially important in that region, since grazing animals have substantially altered and are continuing to alter the distribution of shrublands, grasslands, and soil exposures. Periodic, synoptic acquisition of MSS and SAR data would be of use in monitoring the dynamics of land-cover change in this environment.
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Hobart, Holly H; Morris, Colleen A; Mervis, Carolyn B; Pani, Ariel M; Kistler, Doris J; Rios, Cecilia M; Kimberley, Kendra W; Gregg, Ronald G; Bray-Ward, Patricia
2010-05-15
Williams syndrome (WS) is a multisystem disorder caused by deletion of about 1.55 Mb of DNA (including 26 genes) on chromosome 7q11.23, a region predisposed to recombination due to its genomic structure. Deletion of the Williams syndrome chromosome region (WSCR) occurs sporadically. To better define chance for familial recurrence and to investigate the prevalence of genomic rearrangements of the region, 257 children with WS and their parents were studied. We determined deletion size in probands by metaphase FISH, parent-of-origin of the deleted chromosome by molecular genetic methods, and inversion status of the WSCR in both parents by interphase FISH. The frequency of WSCR inversion in the transmitting parent group was 24.9%. In contrast, the rate of inversion in the non-transmitting parent group (a reasonable estimate of the rate in the general population) was 5.8%. There were no significant gender differences with respect to parent-of-origin for the deleted chromosome or the incidence of the inversion polymorphism. There was no difference in the rate of spontaneous abortion for mothers heterozygous for the WSCR inversion relative to mothers without the inversion. We calculate that for a parent heterozygous for a WSCR inversion, the chance to have a child with WS is about 1 in 1,750, in contrast to the 1 in 9,500 chance for a parent without an inversion.
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Perceptual Speech and Paralinguistic Skills of Adolescents with Williams Syndrome
Hargrove, Patricia M.; Pittelko, Stephen; Fillingane, Evan; Rustman, Emily; Lund, Bonnie
2013-01-01
The purpose of this research was to compare selected speech and paralinguistic skills of speakers with Williams syndrome (WS) and typically developing peers and to demonstrate the feasibility of providing preexisting databases to students to facilitate graduate research. In a series of three studies, conversational samples of 12 adolescents with…
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Comprehension of Metaphor and Metonymy in Children with Williams Syndrome
Annaz, Dagmara; Van Herwegen, Jo; Thomas, Michael; Fishman, Roza; Karmiloff-Smith, Annette; Rundblad, Gabriella
2009-01-01
Background: Figurative language, such as metaphor and metonymy, is very common in daily language use. Its underlying cognitive processes are sometimes viewed as lying at the interface of language and thought. Williams syndrome, which is a rare genetic developmental disorder, provides an opportunity to study this interface because individuals with…
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Heiz, J; Majerus, S; Barisnikov, K
2017-09-28
This study examined the spontaneous use of allocentric and egocentric frames of reference and their flexible use as a function of instructions. The computerized spatial reference task created by Heiz and Barisnikov (2015) was used. Participants had to choose a frame of reference according to three types of instructions: spontaneous, allocentric and egocentric. The performances of 16 Williams Syndrome participants between 10 and 41 years were compared to those of two control groups (chronological age and non-verbal intellectual ability). The majority of Williams Syndrome participants did not show a preference for a particular frame of reference. When explicitly inviting participants to use an allocentric frame of reference, all three groups showed an increased use of the allocentric frame of reference. At the same time, an important heterogeneity of type of frame of reference used by Williams Syndrome participants was observed. Results demonstrate that despite difficulties in the spontaneous use of allocentric and egocentric frames of reference, some Williams Syndrome participants show flexibility in the use of an allocentric frame of reference when an explicit instruction is provided. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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Directory of Open Access Journals (Sweden)
Jacques Sohier
2007-01-01
Full Text Available In Carpenter’s Gothic, hatred is given pride of place. William Gaddis delineates a society in which hatred proliferates. Characters are caught in the turmoils of their hatred whether it derives from the Vietnam War or from fundamentalist movements, from their individualistic quest for social recognition or from self-aggrandizement. We mean to develop a typology derived from psychoanalysis and anthropology so as to take into account all the different facets hate has in the novel. We shall devote analyses to jealousy caused by hatred, then describe the primary hate that underpins all types of relationships as a preliminary to questioning the excess that fuels Gaddis’s writing. Lastly, by referring to the author’s non-fictional work we shall put forward the thesis that the voluble protagonist is to a large extent the author’s mouthpiece. McCandless’s vindictive disquisitions on the course of the world will be seen as the equivalent of a tragic mask through which William Gaddis gives vent to his melancholia and intense detestation of the ways of the world.
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William Butcher, Jules Verne inédit, les manuscrits déchiffrés
Merello, Ida
2016-01-01
Les textes de Jules Verne sont des palimpsestes. Ils le sont au sens figuré, nous le savions déjà. Mais ils le sont également au sens propre, comme le montre le bel ouvrage de William Butcher. Ce dernier s’est donné pour objectif d’analyser les manuscrits de Verne parvenus jusqu’à nous. La ressource semble inépuisable : des milliers et des milliers de pages autographes à déchiffrer, à défricher. William Butcher s’est plongé dans ce labeur avec enthousiasme et il en tire de nombreuses informat...
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Sitek, P.; Vilenius, E.; Mall, U.
2008-01-01
We describe the performance evaluation of a sample of InGaAs detectors from which the best unit had to be selected for the flight model of the SIR-2 NIR-spectrometer to be flown on the Chandrayaan-1 mission in 2008.
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David Cronenberg ja William S. Burroughs kutsuvad teid lantshile / Aare Ermel
Ermel, Aare, 1957-2013
1999-01-01
Mängufilm "Alasti eine" ("Naked Lunch") William S. Burroughs' teose järgi : režissöör ja stsenarist David Cronenberg : Suurbritannia - Kanada 1991. Lähemalt režissööri kohta. Ka Nädal nr. 35, lk. 29
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Examining Reports of Mental Health in Adults with Williams Syndrome
Stinton, Chris; Tomlinson, Katie; Estes, Zachary
2012-01-01
Prior research suggests that individuals with Williams syndrome (WS) have a disposition towards anxiety. Information regarding this is typically derived from parents and carers. The perspectives of the individuals with WS are rarely included in research of this nature. We examined the mental health of 19 adults with WS using explicit (psychiatric…
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Human versus Non-Human Face Processing: Evidence from Williams Syndrome
Santos, Andreia; Rosset, Delphine; Deruelle, Christine
2009-01-01
Increased motivation towards social stimuli in Williams syndrome (WS) led us to hypothesize that a face's human status would have greater impact than face's orientation on WS' face processing abilities. Twenty-nine individuals with WS were asked to categorize facial emotion expressions in real, human cartoon and non-human cartoon faces presented…
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Personal Space Regulation in Williams Syndrome: The Effect of Familiarity
Lough, Emma; Flynn, Emma; Riby, Deborah M.
2016-01-01
Personal space refers to a protective barrier that we strive to maintain around our body. We examined personal space regulation in young people with Williams syndrome (WS) and their typically developing, chronological age-matched peers using a parent report questionnaire and a stop-distance paradigm. Individuals with WS were reported by their…
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William Gaddis’s Immortality: Celebration, Cartoon, or Corruption?
Alberts, Crystal
2013-01-01
Although ostensibly a review of 'The Letters of William Gaddis' edited by Steven Moore (Champaign: Dalkey Archive, 2013), this article evaluates Moore’s volume in light of generally accepted practices of scholarly editions and the handling of historical documents. In particular, Alberts compares some of Moore’s edited letters to the originals housed either at Washington University in St. Louis or the Harry Ransom Center at the University of Texas, Austin and reveals issues involving the repre...
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Jarrold, Christopher; Baddeley, Alan D; Phillips, Caroline
2007-02-01
Previous studies have suggested that Williams syndrome and Down syndrome may be associated with specific short-term memory deficits. Individuals with Williams syndrome perform relatively poorly on tests of visuo-spatial short-term memory and individuals with Down syndrome show a relative deficit on verbal short-term memory tasks. However, these patterns of impairments may reflect the impact of generally impaired visuo-spatial processing skills in Williams syndrome, and verbal abilities in Down syndrome. The current study explored this possibility by assessing long-term memory among 15 individuals with Williams syndrome and 20 individuals with Down syndrome using the Doors and People test, a battery which assesses recall and recognition of verbal and visual information. Individuals' performance was standardised for age and level of intellectual ability with reference to that shown by a sample of 110 typically developing children. The results showed that individuals with Down syndrome have no differential deficits in long-term memory for verbal information, implying that verbal short-term memory deficits in this population are relatively selective. Instead both individuals with Down syndrome and with Williams syndrome showed some evidence of relatively poor performance on tests of long-term memory for visual information. It is therefore possible that visuo-spatial short-term memory deficits that have previously been demonstrated in Williams syndrome may be secondary to more general problems in visuo-spatial processing in this population.